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1

Lymphangioma of the vagina.  

UK PubMed Central (United Kingdom)

Background: Vaginal lymphangioma is an extremely rare lesion. Lymphangioma in other areas is usually asymptomatic, and bleeding is a common complication and presentation. Case: We describe the identification of a vaginal lymphangioma in a 47-year-old woman and discuss the histopathology, diagnosis, and management, based on colposcopy and histology results. Conclusion: Vaginal lymphangioma should be identified by histopathology to exclude other malignant tumours in the vagina and to plan appropriate therapy.

Tomai XH; Phan TH

2013-09-01

2

Brenner tumour of the vagina.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Polyps of the vagina are rare and are either of inflammatory/reactive or neoplastic origin. A case of extraovarian Brenner tumour of the vagina in a postmenopausal woman, who presented with a vaginal polyp, is described. The polyp was excised and on histological examination, had the triphasic patter...

Rashid, A M; Fox, H

3

Vagina evaluation by MR imaging  

International Nuclear Information System (INIS)

The author evaluated MR imaging of the vagina under different hormonal stimuli (25 patients) and assessed the role of MR imaging in the evaluation of congenital abnormalities (15 patients), primary (3) and metastatic (5) neoplasms, and reconstructive surgery (3). The findings were confirmed surgically. The appearance of the mucosa and vaginal wall was influenced by hormonal status. The presence of the vagina (45 patients), absence of the vagina (4), and the presence of duplication anomaly (3) were always accurately demonstrated on MR images. Carcinoma and metastases were depicted as tumor interrupting the low intensity signal of the muscular wall of the vagina. In two of three patients who underwent reconstructive surgery, postsurgical perivaginal abscesses developed that were correctly displayed on MR images. The normal and abnormal vaginas were exquisitely shown on MR images. For complicated congenital abnormalities, complications of postreconstructive surgery, and staging of neoplasms, MR imaging should be considered a primary imaging modality.

1986-12-05

4

Brenner tumour of the vagina.  

Science.gov (United States)

Polyps of the vagina are rare and are either of inflammatory/reactive or neoplastic origin. A case of extraovarian Brenner tumour of the vagina in a postmenopausal woman, who presented with a vaginal polyp, is described. The polyp was excised and on histological examination, had the triphasic pattern (transitional, glandular and stromal) characteristic of Brenner tumour. The histogenesis of Brenner tumour is discussed in the context of this unusual location and the controversy of its origin. PMID:7560181

Rashid, A M; Fox, H

1995-07-01

5

Brenner tumour of the vagina.  

UK PubMed Central (United Kingdom)

Polyps of the vagina are rare and are either of inflammatory/reactive or neoplastic origin. A case of extraovarian Brenner tumour of the vagina in a postmenopausal woman, who presented with a vaginal polyp, is described. The polyp was excised and on histological examination, had the triphasic pattern (transitional, glandular and stromal) characteristic of Brenner tumour. The histogenesis of Brenner tumour is discussed in the context of this unusual location and the controversy of its origin.

Rashid AM; Fox H

1995-07-01

6

Antibiotic susceptibility of Atopobium vaginae  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Previous studies have indicated that a recently described anaerobic bacterium, Atopobium vaginae is associated with bacterial vaginosis (BV). Thus far the four isolates of this fastidious micro-organism were found to be highly resistant to metronidazole and susceptible for clindamycin, two antibiotics preferred for the treatment of BV. Methods Nine strains of Atopobium vaginae, four strains of Gardnerella vaginalis, two strains of Lactobacillus iners and one strain each of Bifidobacterium breve, B. longum, L. crispatus, L. gasseri and L. jensenii were tested against 15 antimicrobial agents using the Etest. Results All nine strains of A. vaginae were highly resistant to nalidixic acid and colistin while being inhibited by low concentrations of clindamycin (range: G. vaginalis strains were also susceptible for clindamycin ( 256 ?g/ml) but susceptible to clindamycin (0.023 – 0.125 ?g/ml). Conclusion Clindamycin has higher activity against G. vaginalis and A. vaginae than metronidazole, but not all A. vaginae isolates are metronidazole resistant, as seemed to be a straightforward conclusion from previous studies on a more limited number of strains.

De Backer Ellen; Verhelst Rita; Verstraelen Hans; Claeys Geert; Verschraegen Gerda; Temmerman Marleen; Vaneechoutte Mario

2006-01-01

7

Primært malignt melanom i vagina  

DEFF Research Database (Denmark)

We describe a case of malignant melanoma (MM) of the vagina in a 77-year-old woman. The type was nodular, measuring 2,5 × 1,8 cm and located in close relation to the urethra. The patient underwent pelvic exenteration and received no kind of adjuvant therapy. Seven months later, the patient locally had recurrence of the disease. The vagina is a rare location of MM, and the literature in this regard is mostly based on case reports. There is a need for better registration of these patients in order to identify factors that predict prognosis and in order to determine the optimal treatment.

Kahr, Henriette StrØm; Mejlgaard, Else

2013-01-01

8

Yolk Sac Tumor of Vagina  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant germ-cell tumors (MGCT) are rare tumors of childhood accounting for less than 3% of pediatric malignancies.Endodermal sinus tumor(EST)forms the most common histologic subtype of MGCT.The vagina is an extremely rare site for GCTs. An 8-month-old female was admitted with a short history of vaginal bleeding,and a mass protruding from the vagina.She was pale and a mass was palpable anteriorly on rectal examination.Computed tomography (CT) showed a tumor mass posterior to the bladder.A biopsy revealed a vaginal EST. The serum alpha-fetoprotein(AFP)was elevated.Vaginohysterectomy was done.The patient was subsequently referred to the oncologist for further management.EST is the most common GCT in children.In females,itis usually encountered in the ovary.EST of the vagina is a rare,highly malignant GCT that exclusively involves children less than 3years of age.The diagnosis is based on histology and raised AFP.Vaginal EST is both locally aggressive and capable of metastasis. The serum AFP level is a useful marker for diagnosis and monitoring the recurrence of vaginal EST in infants.

PARVIN MAHZOUNI; SHERVIN PEJHAN; MAHMOUD ASHRAFI

2006-01-01

9

Vagina invasion by cervical carcinoma.  

Directory of Open Access Journals (Sweden)

Full Text Available Seventy patients with cervical carcinoma who underwent radical hysterectomy and pelvic lymphadenectomy were evaluated to assess spread to the vagina. The overall vaginal invasion rate was 34.2% (24/70), with 36% (21/58) by squamous cell carcinoma, 25% (2/8) by adenocarcinoma and 25% (1/4) by adenosquamous carcinoma. A high vaginal invasion rate (45.7%) was noted in cases in which the cervical lesion was greater than 21 mm (p less than 0.05). Combined parametrial extention (45%) and combined lymph node metastasis (33.3%) were significantly higher in the vaginal invasion cases. The diagnostic accuracy of colposcopy and the Schiller test was 80% and 67% respectively. Histologically, the course of vaginal invasion by squamous cell carcinoma could be divided into : a) continuous invasion (16/21), b) incontinuous invasion via vessel permeation (3/21) and c) combined invasion (2/21). Both cases of vaginal invasion by adenocarcinoma were noted to spread by vessel permeation. Of the 7 cases of vessel permeation, colposcopic examination was positive in only one case. A high percentage of parametrial involvement and lymph node metastasis was noted in the vessel permeation type.

Chen,Neng-Jing

1984-01-01

10

Bacterial vaginosis, Atopobium vaginae and nifuratel.  

Science.gov (United States)

As bacterial vaginosis (BV) is a potential cause of obstetric complications and gynecological disorders, there is substantial interest in establishing the most effective treatment. Standard treatment - metronidazole or clindamycin, by either vaginal or oral route ? is followed by relapses in about 30% of cases, within a month from treatment completion. This inability to prevent recurrences reflects our lack of knowledge on the origins of BV. Atopobium vaginae has been recently reported to be associated with BV in around 80% of the cases and might be involved in the therapeutic failures. This review looks at the potential benefits of nifuratel against A. vaginae compared to the standard treatments with metronidazole and clindamycin. In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 ?g/mL; it is active against G. vaginalis and does not affect lactobacilli. Metronidazole is active against A. vaginae only at very high concentrations (8-256 ?g/mL); it is partially active against G. vaginalis and also has no effect on lactobacilli. Clindamycin acts against A. vaginae with an MIC lower than 0.125 ?g/mL and is active on G. vaginalis but it also affects lactobacilli, altering the vaginal environment. These observations suggest that nifuratel is probably the most valid therapeutic agent for BV treatment. PMID:22082330

Polatti, Franco

2012-02-01

11

Bacterial vaginosis, Atopobium vaginae and nifuratel.  

UK PubMed Central (United Kingdom)

As bacterial vaginosis (BV) is a potential cause of obstetric complications and gynecological disorders, there is substantial interest in establishing the most effective treatment. Standard treatment - metronidazole or clindamycin, by either vaginal or oral route ? is followed by relapses in about 30% of cases, within a month from treatment completion. This inability to prevent recurrences reflects our lack of knowledge on the origins of BV. Atopobium vaginae has been recently reported to be associated with BV in around 80% of the cases and might be involved in the therapeutic failures. This review looks at the potential benefits of nifuratel against A. vaginae compared to the standard treatments with metronidazole and clindamycin. In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 ?g/mL; it is active against G. vaginalis and does not affect lactobacilli. Metronidazole is active against A. vaginae only at very high concentrations (8-256 ?g/mL); it is partially active against G. vaginalis and also has no effect on lactobacilli. Clindamycin acts against A. vaginae with an MIC lower than 0.125 ?g/mL and is active on G. vaginalis but it also affects lactobacilli, altering the vaginal environment. These observations suggest that nifuratel is probably the most valid therapeutic agent for BV treatment.

Polatti F

2012-02-01

12

Vagina heavy punch type draw hook  

UK PubMed Central (United Kingdom)

The utility model provides a vagina heavy punch type draw hook, belonging to the technical field of medical equipment, and aiming at solving the problem that the existing vagina heavy punch type draw hook is bad in operability. The vagina heavy punch type draw hook comprises a handle and a draw hook blade which is formed by bending the handle. The vagina heavy punch type draw hook is characterized in that a free end of the draw hook blade is provided with a hook blade head, the cross sectional area of the hook blade head is gradually reduced from a near hook blade head end to a far hook blade head, and end faces of the hook blade head are in smooth connection with one another. The free end of the draw hook blade is provided with the hook blade head, and the cross sectional area of the hook blade head is gradually reduced from the near hook blade head end to the far hook blade head, so that the vagina heavy punch type draw hook is not only convenient to imbed but also good in operability.

LIQIAN ZHANG

13

Reconstruction of congenital defects of the vagina.  

UK PubMed Central (United Kingdom)

Congenital absence of the vagina is a relatively rare condition most commonly associated with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. Historically, several reconstructive techniques have been described to provide for functional vaginal reconstruction on these patients, both operative and nonoperative. Although there are many advantages and disadvantages of the various procedures, one experience with the use of split thickness skin grafts to reconstruct the vagina has produced acceptable functional results with limited donor site morbidity. Careful planning and timing of this form of reconstruction can produce predictable results in patients who are nearing sexual maturity.

Eldor L; Friedman JD

2011-05-01

14

Adenocarcinoma de células claras de la vagina  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Se presenta un caso clínico de adenocarcinoma de células claras de vagina en mujer de 23 años, sin antecedentes de exposición intrauterina a dietilestilbestrol. Se efectuó colpohisterectomía radical, linfadenectomía pélvica completa y ooforopexia bilateral, más radioterapia externa adyuvante (45 Gy). Sin evidencia de enfermedad a 5 meses de completada su terapia Abstract in english A case of clear cell adenocarcinoma of the vagina in a 23 year old woman, without diethylstilbestrol intrauterine exposure, is presented. The surgical and the radiotherapy treatment are discussed. Without evidence of disease at 5 months follow up. A brief discussion of literature is also provided Vaginal adenocarcinoma diethylstilbestrol

Urrejola S., Rubén; Carrasco T., Ana María; Heredia M., Fernando

2004-01-01

15

Adenocarcinoma de células claras de la vagina  

Directory of Open Access Journals (Sweden)

Full Text Available Se presenta un caso clínico de adenocarcinoma de células claras de vagina en mujer de 23 años, sin antecedentes de exposición intrauterina a dietilestilbestrol. Se efectuó colpohisterectomía radical, linfadenectomía pélvica completa y ooforopexia bilateral, más radioterapia externa adyuvante (45 Gy). Sin evidencia de enfermedad a 5 meses de completada su terapiaA case of clear cell adenocarcinoma of the vagina in a 23 year old woman, without diethylstilbestrol intrauterine exposure, is presented. The surgical and the radiotherapy treatment are discussed. Without evidence of disease at 5 months follow up. A brief discussion of literature is also provided

Rubén Urrejola S.; Ana María Carrasco T.; Fernando Heredia M.

2004-01-01

16

Primary leiomyosarcoma of vagina: case report  

International Nuclear Information System (INIS)

Primary malignant lesions of the vagina are uncommon and represent about 1% of all gynecological malignancies. Most of these neoplasms are carcinomas. Sarcomas comprise less than 2% of all malignant vaginal tumours. In this present article, we describe a primary vaginal leiomyosarcoma in a 40-years-old woman. (author)

2004-01-01

17

Reconstruction of Congenital Defects of the Vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Congenital absence of the vagina is a relatively rare condition most commonly associated with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. Historically, several reconstructive techniques have been described to provide for functional vaginal reconstruction on these patients, both operative and non...

Eldor, Liron; Friedman, Jeffrey D.

18

Cáncer primario de vagina/ Vaginal primary cancer  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish El carcinoma primario de vagina es una neoplasia poco frecuente, representando solamente el 1-2 % de todos los tumores malignos del área ginecológica. Según la FIGO solo se considera como cáncer primario de vagina a aquellas lesiones confinadas a la vagina sin invasión del cuello uterino o la vulva. El pronóstico depende principalmente del estadio en que se encuentra la enfermedad, pero la supervivencia se reduce en pacientes mayores de 60 años de edad, si son sint (more) omáticos al momento del diagnóstico, tienen lesiones del centro y tercio inferior de la vagina o tienen tumores mal diferenciados. Los objetivos de este estudio fueron evaluar la experiencia en el manejo del cáncer primario de vagina, identificar variables demográficas y clínicas, mostrar la variedad histológica de presentación de esta neoplasia tan rara, así como el grado de diferenciación en cada caso. Igualmente relacionar estadio del cáncer, tratamiento y respuesta en cada una de las pacientes. Se trata de un estudio retrospectivo de cinco pacientes con cáncer primario de vagina atendidas en el Servicio de Patología de cuello del Hospital Ramón González Coro, durante el año 2008. La evaluación inicial consistió en una historia clínica completa, examen físico haciendo hincapié en el área ginecológica descartando lesiones en vulva o cuello uterino. A todas las pacientes se les realizó biopsia excisional del tumor, enviando la muestra al estudio histopatológico. Se les realizó cistoscopia, rectoscopia, urograma descendente, a aquellas pacientes con sospecha de infiltración de vejiga o recto, laboratorio, radiografía del tórax y se estadiaron según la clasificación de la FIGO. Abstract in english The primary vaginal carcinoma is a uncommon neoplasm present only in the 1-2% of all the malignant tumors of gynecology area. According to International Federation of Gynecology and Obstetrics only is considered as a primary vaginal cancer of those lesions confined to vagina without invasion of cervix or the vulva. The prognosis depends mainly on the disease stage, but the survival is reduced in patients aged over 60 if they are symptomatic at diagnosis, have lesions of t (more) he center and the inferior third of vagina or have ill-differentiated. The objectives of present study were to assess the experience in the vaginal primary cancer management, to identify demographic and clinical variables, to show the histological variety of presentation of this so rare neoplasm, as well as the differentiation grade of each case and to relate the cancer stage, the treatment and the response of each patient. It is retrospective study conducted in 5 patients presenting vaginal primary cancer seen in the Cervix Pathology Service of the "Ramón González Coro" Gynecology and Obstetrics Hospital during 2008. The initial assessment included a complete medical record, physical examination with emphasis in the gynecological area ruling out vulva or cervix uteri lesions. All patients underwent excision biopsy of tumor with the corresponding histopathological study of the sample. A cystoscopy, rectoscopy descending urogram were carried out in those patients with a possible bladder or rectum infiltration, lab tests, thorax Rx staged according the International Federation of Gynecology and Obstetrics classification.

Ruiz Lorente, Raiza; Hernández Durán, Daisy; Tamayo Lien, Tania Graciela; de la Torre, Ana Isabel

2010-09-01

19

Cáncer primario de vagina Vaginal primary cancer  

Directory of Open Access Journals (Sweden)

Full Text Available El carcinoma primario de vagina es una neoplasia poco frecuente, representando solamente el 1-2 % de todos los tumores malignos del área ginecológica. Según la FIGO solo se considera como cáncer primario de vagina a aquellas lesiones confinadas a la vagina sin invasión del cuello uterino o la vulva. El pronóstico depende principalmente del estadio en que se encuentra la enfermedad, pero la supervivencia se reduce en pacientes mayores de 60 años de edad, si son sintomáticos al momento del diagnóstico, tienen lesiones del centro y tercio inferior de la vagina o tienen tumores mal diferenciados. Los objetivos de este estudio fueron evaluar la experiencia en el manejo del cáncer primario de vagina, identificar variables demográficas y clínicas, mostrar la variedad histológica de presentación de esta neoplasia tan rara, así como el grado de diferenciación en cada caso. Igualmente relacionar estadio del cáncer, tratamiento y respuesta en cada una de las pacientes. Se trata de un estudio retrospectivo de cinco pacientes con cáncer primario de vagina atendidas en el Servicio de Patología de cuello del Hospital Ramón González Coro, durante el año 2008. La evaluación inicial consistió en una historia clínica completa, examen físico haciendo hincapié en el área ginecológica descartando lesiones en vulva o cuello uterino. A todas las pacientes se les realizó biopsia excisional del tumor, enviando la muestra al estudio histopatológico. Se les realizó cistoscopia, rectoscopia, urograma descendente, a aquellas pacientes con sospecha de infiltración de vejiga o recto, laboratorio, radiografía del tórax y se estadiaron según la clasificación de la FIGO.The primary vaginal carcinoma is a uncommon neoplasm present only in the 1-2% of all the malignant tumors of gynecology area. According to International Federation of Gynecology and Obstetrics only is considered as a primary vaginal cancer of those lesions confined to vagina without invasion of cervix or the vulva. The prognosis depends mainly on the disease stage, but the survival is reduced in patients aged over 60 if they are symptomatic at diagnosis, have lesions of the center and the inferior third of vagina or have ill-differentiated. The objectives of present study were to assess the experience in the vaginal primary cancer management, to identify demographic and clinical variables, to show the histological variety of presentation of this so rare neoplasm, as well as the differentiation grade of each case and to relate the cancer stage, the treatment and the response of each patient. It is retrospective study conducted in 5 patients presenting vaginal primary cancer seen in the Cervix Pathology Service of the "Ramón González Coro" Gynecology and Obstetrics Hospital during 2008. The initial assessment included a complete medical record, physical examination with emphasis in the gynecological area ruling out vulva or cervix uteri lesions. All patients underwent excision biopsy of tumor with the corresponding histopathological study of the sample. A cystoscopy, rectoscopy descending urogram were carried out in those patients with a possible bladder or rectum infiltration, lab tests, thorax Rx staged according the International Federation of Gynecology and Obstetrics classification.

Raiza Ruiz Lorente; Daisy Hernández Durán; Tania Graciela Tamayo Lien; Ana Isabel de la Torre

2010-01-01

20

Radiation treatment policy for carcinoma vagina  

International Nuclear Information System (INIS)

[en] A small group of patients of primary carcinoma vagina is presented with their clinical profile and with an emphasis on external radiation therapy for such cases. Short-term control rate has been encouraging. It is recommended that an aggressive treatment policy even in locally advanced tumour and radical radiation with suitable branchytherapy practices can give as good results as with surgery with minimum of morbidity. Relevant literature has been reviewed. (auth.)

1979-01-01

 
 
 
 
21

Primary leiomyosarcoma of vagina: case report; Leiomiossarcoma primario de vagina: relato de caso  

Energy Technology Data Exchange (ETDEWEB)

Primary malignant lesions of the vagina are uncommon and represent about 1% of all gynecological malignancies. Most of these neoplasms are carcinomas. Sarcomas comprise less than 2% of all malignant vaginal tumours. In this present article, we describe a primary vaginal leiomyosarcoma in a 40-years-old woman. (author)

Vieira, Leonardo Jose [Hospital ASCONCER Associacao Feminina de Prevencao e Combate ao Cancer, Juiz de Fora, MG (Brazil). Servico de Cirurgia; Freitas, Rosyane Rena de [Juiz de Fora Univ., MG (Brazil). Faculdade de Medicina; Oliveira, Alexandre Ferreira de [Juiz de Fora Univ., MG (Brazil). Faculdade de Medicina. Disciplina de Cirurgia Gastroenterologica; Assis, Raimunda Violante Campos de [Juiz de Fora Univ., MG (Brazil). Faculdade de Medicina. Dept. de Patologia; Cugola, Elaine Aline; Costa, Sandra Marcia Carvalho Ribeiro

2004-07-01

22

Tubulo-squamous polyp of the vagina.  

UK PubMed Central (United Kingdom)

We report a case of an 86-year-old female with a tubulo-squamous polyp of the vagina. Grossly, the polyp measured 2 x 1.5 x 1 cm. Histologically, it was composed of well-circumscribed nests of squamous cells with bland nuclei. Some of the squamous nests showed central spaces filled with necrotic debris. Small tubules were present at the periphery of some of the nests, and there were a few tubules unassociated with the squamous nests. Furthermore, several larger mucinous glands, some with apparent squamous metaplasia, were present. The stroma was fibrous and rather hypocellular. Surface of the polyp was covered by intact squamous epithelium, which was not connected with the underlying lesion. The recently described tubulo-squamous vaginal polyp represents a distinctive entity. To the best of our knowledge, only one study describing a series of ten cases has been reported in the literature to date.

Dundr P; Povýsil C; Mára M; Kuzel D

2008-04-01

23

Tubulo-squamous polyp of the vagina.  

Science.gov (United States)

We report a case of an 86-year-old female with a tubulo-squamous polyp of the vagina. Grossly, the polyp measured 2 x 1.5 x 1 cm. Histologically, it was composed of well-circumscribed nests of squamous cells with bland nuclei. Some of the squamous nests showed central spaces filled with necrotic debris. Small tubules were present at the periphery of some of the nests, and there were a few tubules unassociated with the squamous nests. Furthermore, several larger mucinous glands, some with apparent squamous metaplasia, were present. The stroma was fibrous and rather hypocellular. Surface of the polyp was covered by intact squamous epithelium, which was not connected with the underlying lesion. The recently described tubulo-squamous vaginal polyp represents a distinctive entity. To the best of our knowledge, only one study describing a series of ten cases has been reported in the literature to date. PMID:18819327

Dundr, P; Povýsil, C; Mára, M; Kuzel, D

2008-04-01

24

Primary Small Cell Carcinoma of the Vagina  

Science.gov (United States)

The primary small cell carcinoma of the vagina is rare, and it is a highly aggressive malignancy with no consensus regarding the treatment of this tumor. The survival rate for patients treated in the early stages is around two years. We related the case report of a patient of 41 years with a vegetative and necrotic lesion in left vaginal wall, in middle and upper third, and involvement of parametrium in its proximal third and medium third. A biopsy showed a small cell undifferentiated carcinoma composed of epithelial cells with round nuclei, oval or elongated, hyperchromatic nuclei, with little distinct nucleoli, and scarce cytoplasm. Immunohistochemistry showed positivity for AE1/AE3, CD57, and chromogranin A. The patient received 6 cycles of chemotherapy with cisplatin and etoposide and radiotherapy, achieving complete response, with complete regression of the lesion. The patient had no sign of tumor recurrence and locoregional or distant metastases after 5 months of followup.

Oliveira, Rafael; Bocoli, Mayra Coelho; Saldanha, Joao Carlos; Murta, Eddie Fernando Candido; Nomelini, Rosekeila Simoes

2013-01-01

25

Susceptibility testing of Atopobium vaginae for dequalinium chloride  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Atopobium vaginae and Gardnerella vaginalis are major markers for bacterial vaginosis. We aimed to determine the MIC and MBC range of the broad-spectrum anti-infective and antiseptic dequalinium chloride for 28 strains, belonging to 4 species of the genus Atopobium, i.e. A. vaginae, A. minutum, A. rimae and A. parvulum. Methods The MIC was determined with a broth microdilution assay. Results The MIC and MBC for Atopobium spp. for dequalinium chloride ranged between Conclusions This study demonstrated that dequalinium chloride inhibits and kills clinical isolates of A. vaginae at concentrations similar to those of clindamycin and lower than those of metronidazole.

Lopes dos Santos Santiago Guido; Grob Philipp; Verstraelen Hans; Waser Florian; Vaneechoutte Mario

2012-01-01

26

Device for feeding medicine into vagina  

UK PubMed Central (United Kingdom)

The utility model provides a vagina administration device, pertaining to the field of medical apparatus for gynecologic disease treatment. The utility model comprises an external pipe and a propel rod wherein, the propel rod is extended inside the external pipe and can make movement opposite to the external pipe a cylindrical medicine cavity with a little bigger diameter which can contain medicine is arranged at the front end of the external pipe a block ring is arranged at the tail end of the external pipe. The utility model is characterized in that a medicine claw is arranged at the front end of the propel rod and composed of over 2 petal-shaped memory metal sheets when the medicine claw is in the medicine cavity, each memory metal sheets will be folded like a sack under the effect of the medicine cavity wall when the medicine claw extends outside the medicine cavity, the memory metal sheets will automatically open a propel plate is arranged at the tail end of the propel rod a compression spring is nested on the propel rod between the block ring and the propel plate the medicine claw enters in the medicine cavity under the effect of the compression spring, and the propelled distance of the propel plate is longer than the length of the medicine cavity. The utility model has the advantages of wide application range, simple structure and convenient auto-administration.

XIAOGE LU

27

Radiation therapy for carcinoma of vagina  

Energy Technology Data Exchange (ETDEWEB)

Thirty-four patients with carcinoma of the vagina were treated by radiotherapy at the Hyogo Medical Center for Adults between April 1965 and May 1990. All patients were treated with a combination of external and intracavitary or interstitial irradiation. Twenty-three patients had squamous cell carcinoma, five had adenocarcinoma and two had malignant melanoma. The five-year survival of patients with squamous cell carcinoma was 70% in Stage I (10 patients), 40% in Stage II (seven patients), 50% in Stage III (three patients) and 0% in Stage IV (three patients). Local control was achieved in 72.7% of the patients with squamous cell carcinoma and 60% of those with adenocarcinoma. However, neither of the malignant melanomas was controlled. Five patients had severe complications that required surgical treatment: severe proctitis and small-bowel perforation, ileus, rectal stenosis, vesicovaginal fistula and small-bowel perforation. Local and pelvic failure was noted in three patients. Patients with previous hysterectomy were more likely to develop serious treatment-related complications. (author).

Mieda, Chieko; Hirota, Saeko; Soejima, Toshinori (Hyogo Medical Center for Adults, Akashi (Japan)) (and others)

1993-07-01

28

Primary malignant melanoma of the vagina: a case report  

Energy Technology Data Exchange (ETDEWEB)

A primary malignant melanoma of the vagina is a very rare gynecological malignant tumor. Its clinical behavior is more aggressive than that of cutaneous and vulvar melanomas. We present a case of a large sized primary melanoma of the lower third of the vagina, with a cervical lesion, in a 58-year-old postmenopausal woman. The patient was treated with conventional external radiation therapy and intracavitary radiotherapy (lCR), without surgical treatment. Although the primary lesion showed a partial response, the patient died of extensive metastases, which were found 4.5 months after the initial diagnosis. We suggest that shortening the treatment period, such as hypofractionated radiation therapy and surgical removal, and various systemic therapies for preventing early distant metastasis, are appropriate treatments for a primary malignant melanoma of the vagina, with a large tumor size.

Jang, Ji Young; Kim, Do Kang; Lee, Eun Hee [College of Medicine, Catholic Univ., Seoul (Korea, Republic of); Kim, Jun Sang [College of Medicine, Chungnam National Univ., Daejeon (Korea, Republic of)

2003-09-01

29

Primary malignant melanoma of the vagina: a case report  

International Nuclear Information System (INIS)

[en] A primary malignant melanoma of the vagina is a very rare gynecological malignant tumor. Its clinical behavior is more aggressive than that of cutaneous and vulvar melanomas. We present a case of a large sized primary melanoma of the lower third of the vagina, with a cervical lesion, in a 58-year-old postmenopausal woman. The patient was treated with conventional external radiation therapy and intracavitary radiotherapy (lCR), without surgical treatment. Although the primary lesion showed a partial response, the patient died of extensive metastases, which were found 4.5 months after the initial diagnosis. We suggest that shortening the treatment period, such as hypofractionated radiation therapy and surgical removal, and various systemic therapies for preventing early distant metastasis, are appropriate treatments for a primary malignant melanoma of the vagina, with a large tumor size

2003-01-01

30

Susceptibility testing of Atopobium vaginae for dequalinium chloride.  

UK PubMed Central (United Kingdom)

BACKGROUND: Atopobium vaginae and Gardnerella vaginalis are major markers for bacterial vaginosis. We aimed to determine the MIC and MBC range of the broad-spectrum anti-infective and antiseptic dequalinium chloride for 28 strains, belonging to 4 species of the genus Atopobium, i.e. A. vaginae, A. minutum, A. rimae and A. parvulum. METHODS: The MIC was determined with a broth microdilution assay. RESULTS: The MIC and MBC for Atopobium spp. for dequalinium chloride ranged between < 0.0625 and 2 ?g/ml. CONCLUSIONS: This study demonstrated that dequalinium chloride inhibits and kills clinical isolates of A. vaginae at concentrations similar to those of clindamycin and lower than those of metronidazole.

Lopes dos Santos Santiago G; Grob P; Verstraelen H; Waser F; Vaneechoutte M

2012-01-01

31

Estrogen and progesterone receptors in the human vagina.  

UK PubMed Central (United Kingdom)

Estrogen (E) and progesterone (Pg) receptor (R) levels were determined in the human vagina in relation to menopausal status, day of ovarian cycle and pregnancy. The results obtained confirmed that the human vagina contains ER and, in addition, demonstrated for the first time the presence of PgR in this organ in humans. In cycling women, ER and PgR did not vary significantly during the ovarian cycle; however low (less than or equal to 10 fmoles/mg cytosol protein) concentrations of PgR were more frequently (6 out of 8 cases) detected during the secretory phase. No substantial difference was seen in ER and PgR values between anterior and posterior wall of the vagina. In postmenopausal patients the levels of ER (range: 10-83 fmoles/mg) were similar to those found in premenopause (range: 12-78 fmoles/mg). As regards PgR, the majority (14 out of 20) of vaginae were devoid of PgR, 4 had a very low (less than or equal to 6 fmoles/mg) PgR content and only 2 cases had a PgR level higher than 10 fmol/mg cytosol protein. In pregnant patients (6th to 8th week) ER were found in all vaginae, while PgR were present only in some cases (3 out of 8). It was concluded that the behavior of ER in the human vagina seems different from that in the human endometrium, since ER levels do not vary in relation to changes in the concentrations of sexual hormones in the circulation. On the contrary, PgR levels appear to depend on blood estradiol and progesterone concentration, as in other target tissues.

Di Carlo F; Racca S; Gallo E; Conti G; Russo A; Mondo F; Francalanci S

1985-04-01

32

Surgically shortened vagina lengthened by laparoscopic davydov procedure.  

UK PubMed Central (United Kingdom)

BACKGROUND: The laparoscopic Davydov procedure is a neovagina surgical technique most commonly used in patients with vaginal agenesis. We present a unique case of vaginal length restoration using this procedure in a patient with vaginal shortening after multiple vaginal surgeries. CASE: A 62-year-old patient presented to our office after multiple vaginal surgeries with symptoms suggestive of cystocele, rectocele, vaginal vault prolapse, and dyspareunia. Excessive vaginal shortening and a painful vaginal apex were also noted upon initial examination. A laparoscopic Davydov procedure was performed to lengthen the vagina and to eliminate the apical pain. CONCLUSION: The laparoscopic Davydov procedure is a surgical option for patients with surgically shortened vaginas and dyspareunia.

Moriarty CR; Miklos JR; Moore RD

2013-09-01

33

[Recurrence in a case of rhabdomyoma of the vagina].  

Science.gov (United States)

Case of a rhabdomyoma of the vagina in a 49 yr-old lady has been reported. The lesion has recurred 4 years after. This appears to be the first case reported in the literature and is similar to a case of pharyngeal adult rhabdomyoma which has also recurred. It is proposed that the present tumor is neoplastic in origin. PMID:8927437

Losi, L; Choreutaki, T; Nascetti, D; Eusebi, V

1995-12-01

34

Effect of oestrogen on Pasteurella pneumotropica in rat vagina.  

UK PubMed Central (United Kingdom)

The effects of ovarian hormones on the vaginal population of Pasteurella pneumotropica in rats were investigated. Specified-pathogen-free adult female Wistar-Imamichi rats with a 4 day oestrous cycle were inoculated with P. pneumotropica in the vagina. Cyclic changes in the vaginal population of P. pneumotropica were not observed in ovariectomized rats and the bacterial population was at a similar level to that at normal dioestrus. Administration of oestrogen to ovariectomized rats caused an increase in the numbers of P. pneumotropica and total bacteria in the vagina nearly equal to that at oestrus in intact rats. The numbers of these organisms in the vagina of ovariectomized rats treated with progesterone did not change and were similar to those of control ovariectomized rats treated with sesame oil. Vaginal smears of ovariectomized rats treated with oestrogen were characterized by abundant cornified non-nucleated epithelial cells with many adherent Gram-negative coccobacilli and were similar to smears from intact rats at oestrus. These findings suggest that the proliferation of P. pneumotropica at oestrus in rat vagina may be primarily due to the environment provided by the degeneration of vaginal epithelial cells promoted by oestrogen secretion from the ovaries.

Yamada S; Mizoguchi J; Ohtaki T

1986-07-01

35

MORPHOLOGICAL STUDY OF THE VAGINA OF THE Myocastor coypus (COYPU)/ ESTUDIO MORFOLOGICO DE LA VAGINA DE Myocastor coypus (COIPO)  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Myocastor coypus es un roedor de tamaño mediano, considerado internacionalmente como una especie de interés económico por sus cualidades peleteras. El estudio morfológico de su vagina reviste importancia en el marco de investigaciones de su fisiología reproductiva. La vagina de coipos sexualmente maduros se presentó como un órgano tubular, de 10,25 ± 1,40 cm de longitud. La pared vaginal fue muy delgada, distinguiéndose en ella cuatro túnicas: mucosa, subm (more) ucosa, muscular y adventicia o serosa (según la región). Su epitelio de revestimiento era de tipo escamoso estratificado y aglandular. En la túnica muscular se diferenciaron dos capas de tejido muscular liso con abundancia de tejido conectivo. La serosa, conformada por tejido conectivo de aspecto denso, presentó numerosos y grandes vasos sanguíneos Abstract in english The Myocastor coypus (coypu) is a medium size rodent internationally considered as a species of economic interest because its fur. The aims of this work was realized the morphological study of the vagina of coypu. The vagina of sexually mature coypus appeared as a tubular organ, 10.25±1.40 cm long. The vaginal wall was very thin. It was composed by four layers: mucosa, submucosa, muscularis, and adventitia or serosa (according to the region). The lining epithelium of the (more) mucosa was squamous stratified and without glands. Two layers of smooth muscular tissue with abundance of connective tissue were differentiated in the muscularis. The tunica serosa, formed by connective tissue of dense aspect, had numerous big blood vessels

Felipe, Antonio E.; Castro, Alejandra; Callejas, Santiago S.; Cabodevila, Jorge A.

2000-01-01

36

MORPHOLOGICAL STUDY OF THE VAGINA OF THE Myocastor coypus (COYPU) ESTUDIO MORFOLOGICO DE LA VAGINA DE Myocastor coypus (COIPO)  

Directory of Open Access Journals (Sweden)

Full Text Available The Myocastor coypus (coypu) is a medium size rodent internationally considered as a species of economic interest because its fur. The aims of this work was realized the morphological study of the vagina of coypu. The vagina of sexually mature coypus appeared as a tubular organ, 10.25±1.40 cm long. The vaginal wall was very thin. It was composed by four layers: mucosa, submucosa, muscularis, and adventitia or serosa (according to the region). The lining epithelium of the mucosa was squamous stratified and without glands. Two layers of smooth muscular tissue with abundance of connective tissue were differentiated in the muscularis. The tunica serosa, formed by connective tissue of dense aspect, had numerous big blood vesselsMyocastor coypus es un roedor de tamaño mediano, considerado internacionalmente como una especie de interés económico por sus cualidades peleteras. El estudio morfológico de su vagina reviste importancia en el marco de investigaciones de su fisiología reproductiva. La vagina de coipos sexualmente maduros se presentó como un órgano tubular, de 10,25 ± 1,40 cm de longitud. La pared vaginal fue muy delgada, distinguiéndose en ella cuatro túnicas: mucosa, submucosa, muscular y adventicia o serosa (según la región). Su epitelio de revestimiento era de tipo escamoso estratificado y aglandular. En la túnica muscular se diferenciaron dos capas de tejido muscular liso con abundancia de tejido conectivo. La serosa, conformada por tejido conectivo de aspecto denso, presentó numerosos y grandes vasos sanguíneos

Antonio E. Felipe; Alejandra Castro; Santiago S. Callejas; Jorge A. Cabodevila

2000-01-01

37

A case of postirradiated malignant fibrous histiocytoma of the vagina  

International Nuclear Information System (INIS)

An unusual case of postirradiated malignant fibrous histiocytoma of the vagina in a 72-year-old female is reported. The tumor occurred in the radiation field 30 years after radical hysterectomy and preoperative radiation therapy (radium 5,200 mgh) for squamous cell carcinoma of the uterine cervix. She had been disease free for 30 years until she noticed a large mass in the vagina. Cytological study showed mainly two types of non-epithelial malignant cells; spindle-shaped fibroblast-like cells and histiocyte-like cells. Bizarre mono or multinucleated giant cells were often observed. The operative specimen revealed an arrangement composed of short or long spindle cells and vacuolated mononucleated and large multinucleated cells. The diagnosis was comfirmed by immunohistological and ultrastructural study. We have reviewed the literature on malignant fibrous histiocytoma occurring after radiation for cervical carcinoma. (author)

1992-01-01

38

A case of postirradiated malignant fibrous histiocytoma of the vagina  

Energy Technology Data Exchange (ETDEWEB)

An unusual case of postirradiated malignant fibrous histiocytoma of the vagina in a 72-year-old female is reported. The tumor occurred in the radiation field 30 years after radical hysterectomy and preoperative radiation therapy (radium 5,200 mgh) for squamous cell carcinoma of the uterine cervix. She had been disease free for 30 years until she noticed a large mass in the vagina. Cytological study showed mainly two types of non-epithelial malignant cells; spindle-shaped fibroblast-like cells and histiocyte-like cells. Bizarre mono or multinucleated giant cells were often observed. The operative specimen revealed an arrangement composed of short or long spindle cells and vacuolated mononucleated and large multinucleated cells. The diagnosis was comfirmed by immunohistological and ultrastructural study. We have reviewed the literature on malignant fibrous histiocytoma occurring after radiation for cervical carcinoma. (author).

Mori, Yasuhiro; Nei, Hideyuki; Koizumi, Motoiki; Tanaka, Satoshi; Sagae, Satoru; Mizuuchi, Hidemitsu; Ito, Eiki; Kudo, Ryuuichi (Sapporo Medical Coll. (Japan))

1992-11-01

39

Primary Melanoma of the Vagina Treated by Imatinib: Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available Melanoma of the vagina is a rare lesion. It results from the malignant transformation of ectopic melanocytes occurring in post-menopause. The CKIT is expressed in 36% of cases in addition to melanoma markers. Prognosis is poor especially for inoperable and disseminated forms despite systemic therapy. Treatment with Imatinib is an option in cases of metastatic mucosal melanoma with CKIT mutation or amplification. We report the case of post-menopausal women, treated at Hassan II University Hospital, diagnosed with metastatic melanoma of the vagina, that didn’t respond to first line of chemotherapy, and received Imatinib as second line of treatment, with good clinical response and durable stability at radiological assessment.

Karima Oualla; Fatimazahra El’mrabet; Hind Elfatemi; Samia Arifi; Nawfel Mellas; Abdelaziz Banani; Siham Tizniti; Afaf Amarti; Omar Elmesbahi

2013-01-01

40

Radiosterilisation of the vagina in therapeutic doses - does it exist  

International Nuclear Information System (INIS)

The endogenous genital flora is a major source of infections of the female genital tract, especially in patients with cervical or endometrial cancer. Until recently the 'radiosterilisation of the vagina', respectively a prophylactic and/or therapeutic effect of irradiation (external highvoltage as well as intracavitary-radium) concerning infections was postulated in the literature. This theory was disproved in a prospective clinical and bacteriological study covering 48 patients with advanced cervical cancer undergoing primary intracavitary radium-irradiation and 38 patients with inoperable endometrical cancer, undergoing primary iridium-192-afterloading. Following intracavitary radium for cervical cancer some typical nosocomial pathogens like Streptococcus faecalis, Enterobacter, Klebsiella, Proteus and Pseudomonas were isolated significantly more frequently than before treatment. Likewise, the mean number of aerobic bacterial species increased significantly after irradiation. Also primary Ir-192 (afterloading) irradiation did not alter the frequency of isolation of the resident flora in endometrial cancer patients. Therefore, 'radiosterilisation' of the vagina as result of radiotherapy does not exist. (orig.)

1986-01-01

 
 
 
 
41

Management of radionecrosis of the vulva and distal vagina  

Energy Technology Data Exchange (ETDEWEB)

Twelve patients were seen between January 1983 and June 1989 with the clinical diagnosis of radionecrosis of the vulva or distal vagina. Seven patients received radiation for vulvar cancer, three for distal vaginal cancer, and two for recurrent endometrial cancer. No patient healed spontaneously and the mean delay in surgical therapy was 8.5 months. The radionecrotic site was treated with local therapy, radical local excision (with or without colostomy), or exenteration. The operative defect was closed primarily in three patients and covered with local flaps or myocutaneous flaps in seven patients. The two patients with local care still have radionecrotic ulcers. One of three patients who were closed primarily continues to have an ulcer. All other patients have healed satisfactorily except one who died after two attempts to correct the problem. Radionecrosis of the vulva and distal vagina should generally be treated surgically.

Roberts, W.S.; Hoffman, M.S.; LaPolla, J.P.; Ruas, E.; Fiorica, J.V.; Cavanagh, D. (Univ. of South Florida, Tampa (USA))

1991-05-01

42

Radiation therapy in primary carcinoma of the vagina  

International Nuclear Information System (INIS)

[en] The experiences with irradiation of 25 patients with primary carcinoma of the vagina are presented. The 3-year survival was 36 per cent despite the fact that most of the cases were advanced. Further improvements in survival may probably be achieved with extension of the radium implantation to paravaginal tissues. Choice and technique of treatment must be individualized. Surgery is limited to the more advanced cases with involvement of the bladder and rectum. (Auth.)

1982-01-01

43

Time required for spermatozoa to remain in the vagina of the ewe to ensure conception.  

UK PubMed Central (United Kingdom)

Oestrous ewes (N = 202) were inseminated with 0.1 ml of semen containing 500 X 10(6) motile spermatozoa and the spermatozoa were flushed from their vagina either immediately or 0.25, 0.5, 1, 2, 4 and 8 h after insemination. Pregnancy was determined by returns to service and laparoscopy. Some ewes became pregnant (10.71%) after spermatozoa had been flushed from the vagina only seconds after insemination and about 40% of ewes became pregnant after spermatozoa had been in the vagina for 15 min. Maximum conception (55%) was achieved when spermatozoa had been in the vagina for at least 2 h. It was concluded that the losses of spermatozoa that occur from the vagina will not influence the chance of a ewe conceiving because sufficient spermatozoa to ensure a normal conception move up the reproductive tract before large losses from the vagina take effect.

Tilbrook AJ; Pearce DT

1986-01-01

44

Sensibility of vagina reconstructed by McIndoe method in Mayer-Küster-Rokitansky-Hauser syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available Background/Aim. Congenital absence of vagina is a failure present in Mayer-Küster-Rokitansky-Hauser syndrome. Treatment of this anomaly includes nonoperative and operative procedures. McIndoe procedure uses split skin graft by Thiersch. The aim of this study was to determine sensitivity (touch, warmness, coldness) of a vagina reconstructed by McIndoe method in Mayer-Küster-Rokitansky-Hauser syndrome and compare it with the normal vagina. Methods. A total of 21 female persons with reconstructed vagina by McIndoe method and 21 female persons with normal vagina were observed. All female persons were divided into groups and subgroups (according to age). Sensibility to touch, warmness and coldness were examined, applying VonFrey's esthesiometer and termoesthesiometer for warmness and coldness in three regions of vagina (enter, middle wall, bothom). The number of positive answers was registrated by touching the mucosa regions for five seconds, five times. Results. The obtained results showed that female patients with a reconstructed vagina by McIndoe method, felt touch at the middle part of wall and in the bottom of vagina better than patients with normal one. Also, the first ones felt warmness at the middle part of wall and coldness in the bottom of vagina, better than the patients with normal vagina. Other results showed no difference in sensibility between reconstructed and normal vagina. Conclusion. Various types of sensibility (touch, warmness, coldness) are better or the same in vaginas reconstructed by McIndoe method, in comparison with normal ones. This could be explained by the fact that skin grafts are capable of recovering sensibility.

Vesanovi? Svetlana; Panajotovi? Ljubomir; Garaleji? Elijana

2008-01-01

45

[Case report. Aggressive angiomyxoma of vagina. A rare tumor diagnosed].  

UK PubMed Central (United Kingdom)

The case of a female patient of 35 years of age, with a pedunculated tumor dependent of the vagina, of approximately 25 x 12 x 8 cm, who had a wide resection. The report was consistent with myxoid aggressive angiomyxoma. This is a myxoid mesenchymal neoplasm of slow growth, which mainly appears in deep soft tissues of the pelvic, genital or perineal areas of adult women. It is usually diagnosed after surgical resection by histopathologic examination. Routine evaluation includes: complete physical examination, imaging and pathology report of diagnostic confirmation.

Jiménez-Vieyra CR; Quintana-Romero V; Aguilera-Maldonado LV; Solís-Moreno TK

2013-07-01

46

Primary neuroendocrine carcinoma of the vagina with coexistent atypical vaginal adenosis: a rare entity.  

UK PubMed Central (United Kingdom)

Primary neuroendocrine carcinoma of the female genital tract is a rare entity with aggressive clinical behavior and a poor prognosis. This kind of malignancy arising in the vagina is extremely rare. We report a case of primary neuroendocrine carcinoma of vagina arising in a setting of atypical vaginal adenosis.

Khurana A; Gupta G; Gupta M; Kaur M

2013-04-01

47

Cytologic studies of malignant melanoma of the vagina.  

Science.gov (United States)

Four cases of primary malignant melanoma of the vagina are described and discussed with respect to vaginal smears. Two cases treated with radiotherapy began to increase the amount of the melanin pigment during the course of irradiation. Characteristic cytologic features found in the four cases are summarized as follows: a) Distribution of cell 1) Scattering, no tendency of grouping 2) Moderate anisocytosis and anisokaryosis b) Cytoplasm 1) Cyanophilic wispy cytoplasm 2) Indistinct cytoplasmic rim 3) Relatively clear cytoplasm 4) Relatively low N/C ratio c) Melanin pigment 1) In melanoma cells-finely granular and diffusely packed in cytoplasm 2) In histiocytes-coarsely granular and densely packed in cytoplasm d) Nucleus 1) Extremely eccentric nucleus 2) Thin and irregular nuclear membrane 3) Relatively regular chromatin distribution 4) Finely or moderately granular chromatin pattern 5) Prominent nucleolus 6) Giant malignant cells (3-4 nuclei) 7) Intranuclear vacuole (punched out). PMID:55032

Masubuchi, S; Nagai, I; Hirata, M; Kubo, H; Masubuchi, K

48

Cytologic studies of malignant melanoma of the vagina.  

UK PubMed Central (United Kingdom)

Four cases of primary malignant melanoma of the vagina are described and discussed with respect to vaginal smears. Two cases treated with radiotherapy began to increase the amount of the melanin pigment during the course of irradiation. Characteristic cytologic features found in the four cases are summarized as follows: a) Distribution of cell 1) Scattering, no tendency of grouping 2) Moderate anisocytosis and anisokaryosis b) Cytoplasm 1) Cyanophilic wispy cytoplasm 2) Indistinct cytoplasmic rim 3) Relatively clear cytoplasm 4) Relatively low N/C ratio c) Melanin pigment 1) In melanoma cells-finely granular and diffusely packed in cytoplasm 2) In histiocytes-coarsely granular and densely packed in cytoplasm d) Nucleus 1) Extremely eccentric nucleus 2) Thin and irregular nuclear membrane 3) Relatively regular chromatin distribution 4) Finely or moderately granular chromatin pattern 5) Prominent nucleolus 6) Giant malignant cells (3-4 nuclei) 7) Intranuclear vacuole (punched out).

Masubuchi S Jr; Nagai I; Hirata M; Kubo H; Masubuchi K

1975-11-01

49

Internal motion of the vagina after hysterectomy for gynaecological cancer.  

UK PubMed Central (United Kingdom)

BACKGROUND AND PURPOSE: The purpose of this study was to investigate position changes of the vagina after hysterectomy for early stage cervical or endometrial cancer and their impact on CTV-PTV margins. We also studied their correlation with surrounding organ filling. MATERIALS AND METHODS: Fifteen patients underwent T2-weighted MR scans before and weekly during the course of their EBRT. The vaginal CTVs and the surrounding organs were delineated. PTV margins were derived from the boundaries of the CTVs in the main directions and correlated with changes in the volumes of organs at risk. Additionally we investigated the impact of margin sizes on CTV coverage. RESULTS: The vaginal CTVs change their position in the pelvis during time with a maximum in anterior-posterior direction. The 95% confidence level was 2.3 cm into the anterior or posterior direction, 1.8 cm to left or right and 1.5 cm towards the cranial. With a homogenous 1.5 cm CTV-PTV margin ?5% inadequately covered vaginal CTV was seen in only 3.3% of the measurements. This increased to 20.6% with a margin of 1.0 cm. Concerning the impact of organ filling on vaginal position changes we found the only significant correlation with rectal volume and shift of the vagina towards anterior-posterior. CONCLUSION: To accommodate the changes in the position of the vaginal CTV inhomogeneous PTV margins should be generated with the largest size in the anterior-posterior direction. The position shifts were only weakly related to the volume of the rectum and not at all to the volumes of other parts of the bowel and the bladder.

Jürgenliemk-Schulz IM; Toet-Bosma MZ; de Kort GA; Schreuder HW; Roesink JM; Tersteeg RJ; van der Heide UA

2011-02-01

50

Particles translocate from the vagina to the oviducts and beyond  

Energy Technology Data Exchange (ETDEWEB)

To investigate whether particles deposited in the vagina translocate to the oviducts, 0.3 ml of a 4% bone black suspension was deposited in the posterior vaginal fornix of each of five cynomolgus monkeys (Macaca fascicularis) during their mid-menstrual cycle. Simultaneously, each animal received 10 units of oxytocin by intramuscular injection. The oviducts of three animals were removed 1 hr after administration of the bone black, while those of the remaining two animals were removed 72 hr after dosing. The removed oviducts were flushed with Hank's solution and then with collagenase solution. The solutions were collected in clean vials and filtered. The filters were examined for bone black particles by light microscopy, as were filters through which solution blanks (negative controls) had been passed. Particles resembling bone black were found on all filters. There were no appreciable differences in the number or shape of these particles between the solution-blank filters and the oviduct-flush filters. The particles on both the solution-blank filters and on the oviduct-flush filters probably originated from environmental contamination by ubiquitous carbon particles. While these results suggested that no translocation took place, translocation could not be ruled out with certainty in the absence of quantitative analyses. A more definitive pilot study was then conducted with two dosed monkeys and one control, using talc labelled by neutron activation to circumvent the problem of environmental contamination. Gamma-Ray analysis of tissue and peritoneal lavage samples for the radionuclides /sup 46/Sc, /sup 59/Fe and /sup 60/Co indicated that no measurable quantities (i.e. greater than 0.5 micrograms) of talc translocated from the deposition site in the vagina to the uterine cavity and beyond.

Wehner, A.P.; Hall, A.S.; Weller, R.E.; Lepel, E.A.; Schirmer, R.E.

1985-03-01

51

Definitive radiation therapy for squamous cell carcinoma of the vagina  

International Nuclear Information System (INIS)

Purpose: To evaluate outcome and describe clinical treatment guidelines for patients with primary squamous cell carcinoma of the vagina treated with definitive radiation therapy. Methods and Materials: Between 1970 and 2000, a total of 193 patients were treated with definitive radiation therapy for squamous cell carcinoma of the vagina at The University of Texas M. D. Anderson Cancer Center. The patients' medical records were reviewed to obtain information about patient, tumor, and treatment characteristics, as well as outcome and patterns of recurrence. Surviving patients were followed for a median of 137 months. Survival rates were calculated using the Kaplan-Meier method, with differences assessed using log-rank tests. Results: Disease-specific survival (DSS) and pelvic disease control rates correlated with International Federation of Gynecology and Obstetrics (FIGO) stage and tumor size. At 5 years, DSS rates were 85% for the 50 patients with Stage I, 78% for the 97 patients with Stage II, and 58% for the 46 patients with Stage III-IVA disease (p = 0.0013). Five-year DSS rates were 82% and 60% for patients with tumors ?4 cm or >4 cm, respectively (p = 0.0001). At 5 years, pelvic disease control rates were 86% for Stage I, 84% for Stage II, and 71% for Stage III-IVA (p = 0.027). The predominant mode of relapse after definitive radiation therapy was local-regional (68% and 83%, respectively, for patients with stages I-II or III-IVA disease). The incidence of major complications was correlated with FIGO stage; at 5 years, the rates of major complications were 4% for Stage I, 9% for Stage II, and 21% for Stage III-IVA (p

2005-05-01

52

Recurrent aggressive angiomyxoma of vagina--a case report.  

UK PubMed Central (United Kingdom)

Aggressive angiomyxoma is a rare tumour, which presents as a painless expanding mass in the vulvo-vaginal region. It usually occurs in 2nd to 3rd decades of life. It behaves like a low-grade sarcoma with high propensity for local spread and recurrence and can involve vulva, perineum, vagina and urinary bladder. It is difficult to differentiate clinically this tumour from other mesenchymal tumours occurring in this region. Microscopically it must be differentiated from malignant tumours with myxoid change, like liposarcoma and myxoid leiomyosarcoma. Hence, histopathologic examination has a central role in diagnosis of this tumour. We are presenting a case of young woman, who came with history of swelling in vulva and perineum. Imaging studies in the perineal region revealed a large pelvic mass. Fine needle aspiration cytology was inconclusive due to scanty material. Enucleation of mass was attempted in first surgery but complete extirpation could not be performed. The swelling recurred within few weeks after surgery and required irradiation. A second surgery, however, was successful in complete removal of the tumour.

Sharma JB; Wadhwa L; Malhotra; Arora R; Singh S

2004-07-01

53

Results of radiation therapy of squamous cell carcinoma of vagina  

Energy Technology Data Exchange (ETDEWEB)

Over a period from 1962 to 1982, 31 patients with squamous cell carcinoma in the vagina were treated by irradiation at National Cancer Center Hospital, Tokyo. Of them, 15 patients (48.4%) were over 60 years old. Treatment was done by external irradiation alone or a combination of external and intracavitary or interstitial irradiation. The lesions were classified into stages of the FIGO system. Stage I was found in 11 cases (35.5%), Stage II in 11 cases (35.5%), Stage III in 7 cases (22.6%) and Stage IVa in 1 case (3.2%). Serious complication after treatment was observed in 5 cases (16.1%) which consisted of 2 cases of rectovaginal fistula and one case of rectal constriction, one case of intestinal necrosis and one case of rectal ulcer. Local and pelvic failure was noted in 6 cases (19.4%) which were treated by reirradiation. Prognosis was poor in all cases, except one which was in Stage I. Some subsequent surgical procedures were required for further treatment in those cases. The 5-year survival rates by stage were as follows: 90% (9/10) for cases of Stage I, 22.2% (2/9) for cases of Stage II, 16.7% (1/6) for cases of Stage III and 0% (0/1) for case of Stage IVa.

Tsukiyama, Iwao; Kakehi, Masae; Ono, Ryosuke (National Cancer Center, Tokyo (Japan). Hospital)

1984-06-01

54

[Primary invasive carcinoma of the vagina and 3d degree genital prolapse. Presentation of a case  

UK PubMed Central (United Kingdom)

Primary carcinoma invading vagina is a rare entity, and more so, being associated to genital prolapse. A case of primary carcinoma invading vagina, with a third degree genital prolapse, observed ar the Gynecology Service, Hospital Civil de Especialidades (University of Guadalajara), is presented. It was studied from the clinical and paraclinical viewpoint, as well as the used treatment. Frequency, etiology, age, histology, clinical picture, diagnosis and treatment, are commented upon.

Bernal Bastidas S; Chavira Alvarado A; Briseño Garcia LM

1989-11-01

55

LASER EN EL TRATAMIENTO DE LA NEOPLASIA INTRAEPITELIAL DE VAGINA  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Objetivo: Presentar la experiencia en el tratamiento de la neoplasia intraepitelial de vagina (VAIN) utilizando el láser de CO2. Método: 19 pacientes con el diagnóstico histológico de VAIN fueron tratadas con esta técnica. Se utilizó un diámetro del punto de helio-neón de 1,5 a 2 mm y un poder de densidad de 400 a 500 W/cm². Toda la lesión detectable más un margen de al menos 5 mm de tejido circundante aparentemente normal fueron vaporizados a una profundidad d (more) e 2 mm. Resultados: 12 de las 14 pacientes evaluables lograron una respuesta completa inicial (86%), de éstas 12 hubo 2 recidivas posteriores (17%), obteniendo una curación en 10 de las 14 evaluables (71%). No hubo complicaciones y se preservó una función vaginal normal. Conclusión: La vaporización con láser es una buena modalidad terapéutica en VAIN, particularmente en mujeres jóvenes en que se ha descartado razonablemente la coexistencia de cáncer invasor Abstract in english Objective: To describe our experience in the treatment of vaginal intra-epithelial neoplasia (VAIN) with the use of CO2 laser. Method: Nineteen patients with the diagnosis of VAIN were treated by this technique. We used a spot size of 1.5 to 2 mm and a power density of 400 to 500 W/cm². The entire lesion in addition to at least a 5 mm margin of adjacent tissue were vaporized to a depth of 2 mm. Results: 12 of 14 evaluable patients had an initial complete response (86%), (more) of these 12, there were 2 recurrences (17%), obtaining a 71% cure rate (10/14). There were no complications and preservation of normal vaginal function. Conclusion: Laser vaporization is a very good treatment modality, particularly in young women in whom the co-existence of invasive malignancy has been ruled out

Yazigi I, Roberto; Rodríguez A, Tulio; Contreras M, Luis

2006-01-01

56

LASER EN EL TRATAMIENTO DE LA NEOPLASIA INTRAEPITELIAL DE VAGINA  

Directory of Open Access Journals (Sweden)

Full Text Available Objetivo: Presentar la experiencia en el tratamiento de la neoplasia intraepitelial de vagina (VAIN) utilizando el láser de CO2. Método: 19 pacientes con el diagnóstico histológico de VAIN fueron tratadas con esta técnica. Se utilizó un diámetro del punto de helio-neón de 1,5 a 2 mm y un poder de densidad de 400 a 500 W/cm². Toda la lesión detectable más un margen de al menos 5 mm de tejido circundante aparentemente normal fueron vaporizados a una profundidad de 2 mm. Resultados: 12 de las 14 pacientes evaluables lograron una respuesta completa inicial (86%), de éstas 12 hubo 2 recidivas posteriores (17%), obteniendo una curación en 10 de las 14 evaluables (71%). No hubo complicaciones y se preservó una función vaginal normal. Conclusión: La vaporización con láser es una buena modalidad terapéutica en VAIN, particularmente en mujeres jóvenes en que se ha descartado razonablemente la coexistencia de cáncer invasorObjective: To describe our experience in the treatment of vaginal intra-epithelial neoplasia (VAIN) with the use of CO2 laser. Method: Nineteen patients with the diagnosis of VAIN were treated by this technique. We used a spot size of 1.5 to 2 mm and a power density of 400 to 500 W/cm². The entire lesion in addition to at least a 5 mm margin of adjacent tissue were vaporized to a depth of 2 mm. Results: 12 of 14 evaluable patients had an initial complete response (86%), of these 12, there were 2 recurrences (17%), obtaining a 71% cure rate (10/14). There were no complications and preservation of normal vaginal function. Conclusion: Laser vaporization is a very good treatment modality, particularly in young women in whom the co-existence of invasive malignancy has been ruled out

Roberto Yazigi I; Tulio Rodríguez A; Luis Contreras M

2006-01-01

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Expression of aquaporin proteins in vagina of diabetes mellitus rats.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Aquaporins (AQPs) are membrane proteins that facilitate water movement across biological membranes. Vaginal lubrication may be mediated by blood flow and other potential mechanisms related to transudation of fluid. The most common female sexual dysfunction in diabetes is inadequate vaginal lubrication. AIM: To investigate the expression of AQP1-3 in vaginal tissue of diabetes mellitus rats. METHODS: Female Sprague-Dawley rats (N = 20) were randomly divided into group A (12-week-old nondiabetic control, N = 5), group B (16-week-old nondiabetes control, N = 5), group C (12-week-old diabetes mellitus rats, N = 5), and group D (16-week-old diabetes mellitus rats, N = 5). Vaginal fluid was measured by fluid weight absorbed by cotton swabs after pelvic nerve electrostimulation and anterior vaginal tissue was dissected for determining the expression of AQP1-3 by immunohistochemical study and Western blot. MAIN OUTCOME MEASURES: The expression of AQP1-3 was determined in the vagina of diabetes mellitus rats by Western blot. RESULTS: There are no significant differences in serum estradiol concentrations of rats among these groups (P > 0.05). Vaginal fluid was significantly lower in group C (2.7 ± 0.67 mg) and group D (2.5 ± 1.03 mg) than in group A (5.74 ± 1.23 mg) and group B (5.5 ± 1.08 mg) (P < 0.05), respectively. The protein expressions of AQP1-3 were significantly lower in group C (43.40 ± 4.83, 60.60 ± 12.80, and 59.60 ± 6.95) and group D (20.81 ± 2.86, 47.80 ± 11.43, and 54.20 ± 5.26) than in group A (116.62 ± 3.21, 110.81 ± 8.044, and 108.80 ± 4.97) and group B (122.12 ± 14.54, 111.21 ± 15.07, and 106.40 ± 4.16) (P < 0.05), respectively. CONCLUSIONS: Decreased vaginal fluid in diabetes mellitus rats after electrostimulation may be partly due to estrogen-independent decreases of AQP1-3 in vaginal tissue.

Pei L; Jiang J; Jiang R; Ouyang F; Yang H; Cheng Y; Fan Z

2013-02-01

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Strong correspondence in bacterial loads between the vagina and rectum of pregnant women.  

UK PubMed Central (United Kingdom)

We sampled the vagina and rectum in 71 pregnant women and bacterial loads of Lactobacillus crispatus, L. jensenii, L. gasseri, L. iners, Gardnerella vaginalis and Atopobium vaginae were determined by culture and quantitative PCR (qPCR). Culture and qPCR results differed substantially with regard to the evaluation of vaginal and rectal occurrence of the six species tested. The vaginal-rectal prevalence of L. crispatus, L. jensenii, L. gasseri, L. iners, G. vaginalis and A. vaginae as established by culture vs. PCR was 32.3 vs. 91.5%, 32.3 vs. 77.4%, 28.1 vs. 91.5%, 12.6 vs. 68.5%, 12.6 vs. 74.6% and 5.6 vs. 69.0%, respectively. Using qPCR, a significant positive correlation was found between vaginal and rectal loads of L. crispatus (p < 0.0001), L. jensenii (p < 0.0001), L. gasseri (p = 0.005), L. iners (p = 0.003) and A. vaginae (p = 0.002). In summary, significant correlations between quantities of vaginal and rectal lactobacilli and of Atopobium vaginae were established by means of qPCR, indicating strong correspondence of vaginal and rectal microflora, not only in the occurrence of certain species in both niches, but also of cell densities per bacterial species.

El Aila NA; Tency I; Saerens B; De Backer E; Cools P; dos Santos Santiago GL; Verstraelen H; Verhelst R; Temmerman M; Vaneechoutte M

2011-06-01

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METHOD FOR ELIMINATING GARDNERELLA VAGINALIS AND ATOPOBIUM VAGINAE BACTERIA IN BACTERIAL VAGINOSIS  

UK PubMed Central (United Kingdom)

The invention relates to medicine, and specifically to gynaecology and dermatovenerology, and may find application in the treatment of patients (women and girls) with bacterial vaginosis. The technical result achieved when using the claimed invention is reduction in the cost of treatment and shortening of treatment times due to elimination of the conditionally pathogenic microorganisms Gardnerella vaginalis and Atopobium vaginae, and elimination of recurrences of the illness with a single course of treatment. The claimed technical result is achieved due to use of a method for elimination of the bacteria Gardnerella vaginalis and Atopobium vaginae which is characterized in that the preparation "Macmiror Complex" (nifuratel + nystatin) is used in the form of vaginal suppositories (Poli Industria Chimica S.p.A.). The preparation is introduced into the vagina as one suppository per day over seven or eight days.

PERLAMUTROV JURIJ NIKOLAEVICH; GOMBERG MIHAIL ALEKSANDROVICH; CHERNOVA NADEZHDA IVANOVNA; BOCHKOVA OL GA IGOREVNA; CASTORINA MARINO LORENZO; UDOVICHENKO VICTOR IVANOVICH

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Ultrastructural characteristics of the vaginae of the basal monogenean Chimaericola leptogaster (Leuckart, 1830).  

UK PubMed Central (United Kingdom)

In the first study of the vaginal ultrastructure of any monogenean, the paired vaginae of Chimaericola leptogaster, a basal polyopisthocotylean from the gills of a holocephalan, are described. Each vagina opens laterally. A unique feature of this relict parasite is a short vagino-intestinal connecting duct, the lining of which is separated by septate junctions from the linings of the vagina and the intestine. After giving rise to this vagino-intestinal duct, each vagina travels in a posterior direction and opens into the vitelline collecting duct. The lining of each vagina close to the vaginal pore resembles the body tegument, the syncytial lining of which measures about 2.5 ?m in thickness and has a dense surface layer 0.2 ?m in thickness and different apical projections. Proximal to this and before the entrance to the vaginal-intestinal duct, the vaginal lining is characterised by: uniformly distributed electron-dense, lanceolate, spine-like surface structures of about 1.7 ?m in length; three kinds of surrounding glands with three kinds of secretory granules (abundant oval or rounded electron-dense granules 0.7-2.5 ?m in length, much less numerous spheroidal, vesicular granules 0.3-0.4 ?m in diameter, and tightly packed, spheroidal granules 0.8 ?m in diameter and containing fine particulate material of low density); and four kinds of sensory receptors (three uniciliate and one aciliate). These features are absent from the rest of the vagina. The likely roles of the vagino-intestinal connection, the different gland cells, sensory structures, and the armament of the distal vaginal regions are discussed. Considering the suggested polyopisthocotylean ancestor for the Neodermata, the relict parasite fauna of holocephalans and the unique vagino-intestinal connection in C. leptogaster, which is also known in turbellarians, an ancient origin for chimaericolids is supported.

Poddubnaya LG; Hemmingsen W; Gibson DI

2013-09-01

 
 
 
 
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Committee opinion no. 571: solutions for surgical preparation of the vagina.  

UK PubMed Central (United Kingdom)

: Currently, only povidone-iodine preparations are approved for vaginal surgical-site antisepsis. However, there are compelling reasons to consider chlorhexidine gluconate solutions for off-label use in surgical preparation of the vagina, especially in women with allergies to iodine. Although chlorhexidine gluconate solutions with high concentrations of alcohol are contraindicated for surgical preparation of the vagina, solutions with low concentrations of alcohol (eg, 4%) are both safe and effective for off-label use as vaginal surgical preparations and may be used as an alternative to iodine-based preparations in cases of allergy or when preferred by the surgeon.

2013-09-01

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Committee opinion no. 571: solutions for surgical preparation of the vagina.  

Science.gov (United States)

: Currently, only povidone-iodine preparations are approved for vaginal surgical-site antisepsis. However, there are compelling reasons to consider chlorhexidine gluconate solutions for off-label use in surgical preparation of the vagina, especially in women with allergies to iodine. Although chlorhexidine gluconate solutions with high concentrations of alcohol are contraindicated for surgical preparation of the vagina, solutions with low concentrations of alcohol (eg, 4%) are both safe and effective for off-label use as vaginal surgical preparations and may be used as an alternative to iodine-based preparations in cases of allergy or when preferred by the surgeon. PMID:23963423

2013-09-01

63

Carcinoma of the vulva and vagina in patients irradiated for carcinoma of the cervix  

International Nuclear Information System (INIS)

Six patients with carcinoma of the vulva and 3 with carcinoma of the vagina following radiation therapy for cancer of the cervix were analyzed. The interval between irradiation and diagnosis of the second tumor varied from 5 to 23 years. Despite the lack of having detailed information on irradiation factors in all patients, circumstantial evidence from this study suggests that radiation therapy may have contributed to the development of carcinoma of the vulva and vagina in some of the patients. Close follow-up patients treated for squamous carcinoma of the genital tract must emphasize inspection for new lesions. The incidences previously reported in the literature are also reviewed for comparison. (author).

1984-01-01

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Cytological Diagnosis of Small Cell Carcinoma of Vagina - A Diagnostic Dilemma  

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Full Text Available Small cell carcinoma is a neuroendocrine tumour, mainly arises in lung accounting for 20%of cases. In extra pulmonary sites it accounts for 5% of cases. Among gynaecological malignancies it accounts for 1-2% of cases, common sites are cervix, endometrium, ovary, vagina, vulva in decreasing frequencies. Small cell carcinoma is extremely uncommon in vagina.There are only 26 cases reported in the literature. Here we are reporting 27 th case. Because of its rarity the chances of missing the diagnosis are more. Correct morphological identification, with immunohistochemical analysis is essential for definitive diagnosis which will be helpful in planning appropriate treatment.

Savita S. Shettar; R. M. Potekar; Mahesh Kumar U; B. R. Yelikar

2013-01-01

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Melanoma amelanótico primario de vagina: reporte de un caso y revisión de la literatura/ Primary amelanotic melanoma of the vagina: a case report and literature review  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Objetivo: revisar el diagnóstico clínico, histológico e inmunohistoquímico; las alternativas terapéuticas y los factores que influyen en el pronóstico del melanoma amelanocítico de vagina. Materiales y métodos: se presenta el caso de una paciente de 49 años que consultó por masa vaginal de 8 cm en pared anterior de vagina, nacarada y con fondo necrótico a la Unidad de Patología Cervical y Colposcopia del Hospital de Engativá, institución de segundo nivel de (more) complejidad que atiende pacientes de nivel socioeconómico bajo afiliados al régimen de seguridad pública. Se realizó resección amplia de la lesión. La patología quirúrgica informó melanoma fusocelular y epiteloide maligno. Se realizó una búsqueda sistemática usando las palabras clave: melanoma primario y vagina en las bases de datos Medline vía PubMed, Cochrane y Ebsco. Resultados: se encontraron 489 artículos de los cuales 31 estaban relacionados directamente con el tema, de estos se seleccionaron diez que correspondieron a nueve reportes de caso y a una revisión del tema. El diagnóstico clínico no es fácil. Las proteínas HMB45 y S100 son de gran utilidad en su identificación. La respuesta al tratamiento quirúrgico, la radioterapia y la quimioterapia es pobre. El pronóstico depende de la ploidía, la amelanosis y el índice mitótico. Conclusiones: el melanoma primario de vagina es una neoplasia rara y de mal pronóstico. Hace parte del grupo de melanomas de mucosa que tienen un origen y comportamiento biológico diferente al cutáneo. Tiene tendencia a la diseminación hematógena rápida y a recaídas locales. El tratamiento se basa en cirugía conservadora, radioterapia, quimioterapia y terapia biológica; sin embargo, su eficacia es limitada. Abstract in english Objective: reviewing clinical, histological and immunohistochemical diagnosis, therapeutic alternatives and factors influencing prognosis for amelanotic melanoma of the vagina. Materials and methods: this article presents the case of a 49yearold patient who consulted the Engativá Hospital’s Cervical Pathology and Colposcopy Unit due to an 8 cm diameter necrotic pearlywhite vaginal mass on the anterior vaginal wall. The hospital is a secondary level complexity insti (more) tution dealing with low socioeconomic level patients affiliated to the public (subsidized) social security (health) system. A broad resection was made of the lesion. Surgical pathology revealed epithelioid fusocellular malignant melanoma. A systematic literature search was made using the following key words: primary melanoma and vagina in Medline databases via Pub Med, Cochrane and Ebsco. Results: 31 of the 489 articles found were directly related to the topic; 10 new case reports and a review were selected. Clinical diagnosis is not easy; HMB45 and S100 proteins are extremely useful in identifying it.Response to surgical treatment, radiotherapy and chemotherapy is poor. Prognosis depends on ploidy, amelanosis and mitotic index. Conclusions: Primary melanoma of the vagina is a rare neoplasm and has a poor prognosis. It forms part of a group of mucosal melanoma having an origin and biological behavior different to that of cutaneous melanoma. It tends to have rapid hematogenous dissemination and local relapses. Treatment is based on conservative surgery, radiotherapy, chemotherapy and biological therapy; however, its effectiveness is limited.

Houghton-Martínez, María Paula; Amaya-Guío, Jairo; Díaz-Cruz, Luz Amparo

2012-03-01

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Melanoma amelanótico primario de vagina: reporte de un caso y revisión de la literatura Primary amelanotic melanoma of the vagina: a case report and literature review  

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Full Text Available Objetivo: revisar el diagnóstico clínico, histológico e inmunohistoquímico; las alternativas terapéuticas y los factores que influyen en el pronóstico del melanoma amelanocítico de vagina. Materiales y métodos: se presenta el caso de una paciente de 49 años que consultó por masa vaginal de 8 cm en pared anterior de vagina, nacarada y con fondo necrótico a la Unidad de Patología Cervical y Colposcopia del Hospital de Engativá, institución de segundo nivel de complejidad que atiende pacientes de nivel socioeconómico bajo afiliados al régimen de seguridad pública. Se realizó resección amplia de la lesión. La patología quirúrgica informó melanoma fusocelular y epiteloide maligno. Se realizó una búsqueda sistemática usando las palabras clave: melanoma primario y vagina en las bases de datos Medline vía PubMed, Cochrane y Ebsco. Resultados: se encontraron 489 artículos de los cuales 31 estaban relacionados directamente con el tema, de estos se seleccionaron diez que correspondieron a nueve reportes de caso y a una revisión del tema. El diagnóstico clínico no es fácil. Las proteínas HMB45 y S100 son de gran utilidad en su identificación. La respuesta al tratamiento quirúrgico, la radioterapia y la quimioterapia es pobre. El pronóstico depende de la ploidía, la amelanosis y el índice mitótico. Conclusiones: el melanoma primario de vagina es una neoplasia rara y de mal pronóstico. Hace parte del grupo de melanomas de mucosa que tienen un origen y comportamiento biológico diferente al cutáneo. Tiene tendencia a la diseminación hematógena rápida y a recaídas locales. El tratamiento se basa en cirugía conservadora, radioterapia, quimioterapia y terapia biológica; sin embargo, su eficacia es limitada.Objective: reviewing clinical, histological and immunohistochemical diagnosis, therapeutic alternatives and factors influencing prognosis for amelanotic melanoma of the vagina. Materials and methods: this article presents the case of a 49yearold patient who consulted the Engativá Hospital’s Cervical Pathology and Colposcopy Unit due to an 8 cm diameter necrotic pearlywhite vaginal mass on the anterior vaginal wall. The hospital is a secondary level complexity institution dealing with low socioeconomic level patients affiliated to the public (subsidized) social security (health) system. A broad resection was made of the lesion. Surgical pathology revealed epithelioid fusocellular malignant melanoma. A systematic literature search was made using the following key words: primary melanoma and vagina in Medline databases via Pub Med, Cochrane and Ebsco. Results: 31 of the 489 articles found were directly related to the topic; 10 new case reports and a review were selected. Clinical diagnosis is not easy; HMB45 and S100 proteins are extremely useful in identifying it.Response to surgical treatment, radiotherapy and chemotherapy is poor. Prognosis depends on ploidy, amelanosis and mitotic index. Conclusions: Primary melanoma of the vagina is a rare neoplasm and has a poor prognosis. It forms part of a group of mucosal melanoma having an origin and biological behavior different to that of cutaneous melanoma. It tends to have rapid hematogenous dissemination and local relapses. Treatment is based on conservative surgery, radiotherapy, chemotherapy and biological therapy; however, its effectiveness is limited.

María Paula Houghton-Martínez; Jairo Amaya-Guío; Luz Amparo Díaz-Cruz

2012-01-01

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[Botryoid sarcoma of the vagina. Presentation of a case surviving 10 years  

UK PubMed Central (United Kingdom)

A case of sarcoma botryoides of the vagina in a 15-month old child with a survival of ten years is described. The authors review the clinical and histological characteristics of the neoplasm and the different therapeutic measures employed. They conclude that a multidisciplinary treatment is needed, consisting of surgical removal, combined radiotherapy with intracavitary radium and cobalt 60, and antineoplastic multidrug chemotherapy.

Cáceres Díaz C; Longchong Ramos M

1985-01-01

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Sensibility of vagina reconstructed by McIndoe method in Mayer-Küster-Rokitansky-Hauser syndrome  

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Background/Aim. Congenital absence of vagina is a failure present in Mayer-Küster-Rokitansky-Hauser syndrome. Treatment of this anomaly includes nonoperative and operative procedures. McIndoe procedure uses split skin graft by Thiersch. The aim of this study was to determine sensitivity (touch, warm...

Vesanovi? Svetlana; Panajotovi? Ljubomir; Garaleji? Elijana

69

Morphology of the Turkey Vagina and Uterus With and Without an Egg Mass  

Science.gov (United States)

In this study we examined the gross anatomy of the uterus and vagina in turkeys in egg production. With no uterine egg mass, removal of the tunica serosa that enclosed the uterus revealed deep periodic in-folding of the muscularis transversely circumscribing the sac-like segment. When the connecti...

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Mioepitelioma de vagina: neoplasia poco frecuente en esta localización, reporte de un caso  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Antecedentes: Los mioepiteliomas, son tumores poco frecuentes originados a partir de la proliferación de células mioepiteliales. La mayor parte localizados en las extremidades inferiores y en glándulas salivales. Existen ocasionales informes previos de MEP que involucren la vagina. Objetivo: Describir un caso de mioepitelioma localizado en vagina. Caso clínico: Embarazada de 29 años edad, quien presenta una masa vaginal de un año de evolución, localizada en el hime (more) n. El examen histopatológico muestra una lesión compuesta por células fusiformes con positividad inmunohistoquímica para vimentina, citoqueratinas (CK) AE1/ AE3, S100, CD10, receptores de estrógenos y progesterona, Bcl2 y calponina y negatividad para desmina, actina muscular especifica, actina de músculo liso y p63. Con los anteriores hallazgos se interpreta la lesión como un mioepitelioma primario vaginal. Conclusión: Los mioepiteliomas son tumores que requieren para su diagnostico, análisis con técnicas de inmunohistoquímica o ultraestructurales que permitan diferenciarlos de otros tumores. Abstract in english Background: The myoepitheliomas are rare tumors arising from the proliferation of myoepithelial cells. Most tumors are located in the lower extremity and salivary glands. There have been only occasional myoepithelial neoplasms previously reported involving the vagina. Objective: Describe a case of myoepithelioma located in the vagina of a pregnant woman. Case report: A 29 years old pregnant female, who about 1 year prior has a vaginal mass, located in the hymen. At histop (more) athological examination shows a mass composed of spindle cells with positivity immunohistochemical studies for vimentin, cytokeratin AE1/AE3, S100, CD10 and calponin and negative for desmin, actinmuscle specific (HHF35), smooth muscle actin and p63. With these findings it was established the diagnosis of myoepithelioma in the vagina. Conclusion: Myoepitheliomas are tumors requiring for diagnostic of immunohistochemistry or ultrastructural techniques that allow its differentiation from other tumors.

Romero R, Alfredo; Melo U, Mario; Barajas S, Paula; Baena A, Juvenal; Vargas L, Luz Mery

2012-01-01

71

Mioepitelioma de vagina: neoplasia poco frecuente en esta localización, reporte de un caso  

Directory of Open Access Journals (Sweden)

Full Text Available Antecedentes: Los mioepiteliomas, son tumores poco frecuentes originados a partir de la proliferación de células mioepiteliales. La mayor parte localizados en las extremidades inferiores y en glándulas salivales. Existen ocasionales informes previos de MEP que involucren la vagina. Objetivo: Describir un caso de mioepitelioma localizado en vagina. Caso clínico: Embarazada de 29 años edad, quien presenta una masa vaginal de un año de evolución, localizada en el himen. El examen histopatológico muestra una lesión compuesta por células fusiformes con positividad inmunohistoquímica para vimentina, citoqueratinas (CK) AE1/ AE3, S100, CD10, receptores de estrógenos y progesterona, Bcl2 y calponina y negatividad para desmina, actina muscular especifica, actina de músculo liso y p63. Con los anteriores hallazgos se interpreta la lesión como un mioepitelioma primario vaginal. Conclusión: Los mioepiteliomas son tumores que requieren para su diagnostico, análisis con técnicas de inmunohistoquímica o ultraestructurales que permitan diferenciarlos de otros tumores.Background: The myoepitheliomas are rare tumors arising from the proliferation of myoepithelial cells. Most tumors are located in the lower extremity and salivary glands. There have been only occasional myoepithelial neoplasms previously reported involving the vagina. Objective: Describe a case of myoepithelioma located in the vagina of a pregnant woman. Case report: A 29 years old pregnant female, who about 1 year prior has a vaginal mass, located in the hymen. At histopathological examination shows a mass composed of spindle cells with positivity immunohistochemical studies for vimentin, cytokeratin AE1/AE3, S100, CD10 and calponin and negative for desmin, actinmuscle specific (HHF35), smooth muscle actin and p63. With these findings it was established the diagnosis of myoepithelioma in the vagina. Conclusion: Myoepitheliomas are tumors requiring for diagnostic of immunohistochemistry or ultrastructural techniques that allow its differentiation from other tumors.

Alfredo Romero R; Mario Melo U; Paula Barajas S; Juvenal Baena A; Luz Mery Vargas L

2012-01-01

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Lactobacillus and Pediococcus species richness and relative abundance in the vagina of rhesus monkeys (Macaca mulatta).  

UK PubMed Central (United Kingdom)

BACKGROUND: The rhesus monkey is an important animal model to study human vaginal health to which lactic acid bacteria play a significant role. However, the vaginal lactic acid bacterial species richness and relative abundance in rhesus monkeys is largely unknown. METHODS: Vaginal swab samples were aseptically obtained from 200 reproductive-aged female rhesus monkeys. Following Rogosa agar plating, single bacterial colonies representing different morphotypes were isolated and analyzed for whole-cell protein profile, species-specific polymerase chain reaction, and 16S rRNA gene sequence. RESULTS: ? A total of 510 Lactobacillus strains of 17 species and one Pediococcus acidilactici were identified. The most abundant species was Lactobacillus reuteri, which colonized the vaginas of 86% monkeys. Lactobacillus johnsonii was the second most abundant species, which colonized 36% of monkeys. The majority of monkeys were colonized by multiple Lactobacillus species. CONCLUSIONS: The vaginas of rhesus monkeys are frequently colonized by multiple Lactobacillus species, dominated by L. reuteri.

Gravett MG; Jin L; Pavlova SI; Tao L

2012-06-01

73

[Biocenosis of vagina in women in light of microbiological examinations of vaginal content  

UK PubMed Central (United Kingdom)

The study was aimed at microbiological evaluation of vaginal environment in 6810 women (19-75 years of age). Diagnostic procedure was applied according to accepted scheme, including basic and selected methods. Evaluation was performed by investigation of fresh (Miller's method) and fixed (Gram method) smears of vaginal content of pregnant women, women in childbirth and in women not pregnant, as well in the menopause and the old age. Microbiological pictures of vaginal content were classified according to modified procedure of Manu Af Heurlin. At the same time, cultures were carried on enriched and differentiating media in aerobic and anaerobic conditions. Microbiological investigations of vaginal content permitted for establishment of physiological status of vaginal environment or normal biocenosis of vagina in 3910 (57.4%) of tested patients. Disturbed biocenosis was present in 2900 (42.6%) of women and this included very serious disturbances of biocenosis in 1077 patients. In disturbed biocenosis of vagina, sexually transmissible microorganisms were main cause.

Kuczy?ska K

1993-01-01

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Lactobacillus and Pediococcus species richness and relative abundance in the vagina of rhesus monkeys (Macaca mulatta)  

Science.gov (United States)

Background The rhesus monkey is an important animal model to study human vaginal health to which lactic acid bacteria play a significant role. However, the vaginal lactic acid bacterial species richness and relative abundance in rhesus monkeys is largely unknown. Methods Vaginal swab samples were aseptically obtained from 200 reproductive aged female rhesus monkeys. Following Rogosa agar plating, single bacterial colonies representing different morphotypes were isolated and analyzed for whole-cell protein profile, species-specifc PCR, and 16S rRNA gene sequence. Results A total of 510 Lactobacillus strains of 17 species and one Pediococcus acidilactici were identified. The most abundant species was L. reuteri, which colonized the vaginas of 86% monkeys. L. johnsonii was the second most abundant species, which colonized 36% of monkeys. The majority of monkeys were colonized by multiple Lactobacillus species. Conclusions The vaginas of rhesus monkeys are frequently colonized by multiple Lactobacillus species, dominated by L. reuteri.

Gravett, Michael G.; Jin, Ling; Pavlova, Sylvia I.; Tao, Lin

2012-01-01

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Effect of prolonged use of high dose of tibolone on the vagina of ovariectomized rats.  

Science.gov (United States)

The aim of this study was evaluate the effect of prolonged use of high dose of tibolone on the vagina of ovariectomized rats. Bilateral ovariectomy was performed on 14 rats weighing 250 g. Thirty days later, vaginal smears were collected verifying the menopause status by anoestrus cytology. Rats were divided randomly into groups: experimental rats (n = 9) received 1 mg tibolone/day orally and control rats (n = 6) received placebo (carboxymethylcellulose). After 150 days, all rats were sedated and euthanized by cervical displacement. The vagina was removed, fixed in 10% buffered formalin, sampled and processed for paraffin embedding. Histological sections were stained with haematoxylin and eosin, picrosirius red, periodic acid Schiff (PAS) and PAS-diastase, and Weigert's resorcin-fuchsin. Cell proliferation was analysed by immunohistochemistry to detect Ki67. Histomorphometric analyses were performed for epithelial thickness, per cent area of collagen fibres and blood vessels, mast cells and Ki67-positive nuclei per mm of basal membrane. Means and standard error of means were calculated, and data were compared using the Mann-Whitney test, with significance level at P < 0.05. In the vagina, epithelial thickness, number of Ki67-positive nuclei per mm of basal membrane, number of vessels and number of mast cells were significantly higher in the tibolone group when compared with the control group. Furthermore, the content of glycogen and glycoproteins in the vaginal epithelium was modified by tibolone. Tibolone administered in high dose and for a long period has a trophic effect, reversing vaginal atrophy, and has no dysplastic or neoplastic effect in the vagina of ovariectomized rats. PMID:21518049

Henriques, Helene Nara; de Carvalho, Ana Carolina Bergmann; Soares Filho, Porphirio José; Pantaleão, José Augusto Soares; Guzmán-Silva, Maria Angélica

2011-04-26

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Foreign body in vagina: a cause of persistent vaginal discharge in children  

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Full Text Available Vulvovaginitis and vaginal discharge in pediatric patients, while not uncommon, is commonly believed to be due to such causes as absence of the protective effect on the vaginal mucosa. However, other causes need also to be kept in mind. We report a case of chronic vaginal discharge in a 5 yr old, who had retained a foreign body in her vagina for 6-7 months. [Int J Reprod Contracept Obstet Gynecol 2013; 2(2.000): 224-225

P. Pallavee; Sunita Samal; P. Sabita

2013-01-01

77

A simple, inexpensive applicator for irradiation of localized areas of the vagina with intracavitary brachytherapy  

International Nuclear Information System (INIS)

Purpose: To describe the construction of a simple, inexpensive applicator for irradiation of localized areas of the vagina with intracavitary brachytherapy Methods and Materials: It was desirable to avoid an interstitial implant in an elderly patient with a stage T2 vaginal cancer. The final phase of radiation therapy was delivered with a custom made intracavitary cylinder that allowed the high-dose area to be limited to the portion of the vagina at high risk for residual disease. The applicator was fabricated from a clear cast acrylic (Lucite) rod with dimensions 3.5 cm diameter x 5.0 cm long. The applicator contained 11 parallel grooves, each 1.8 mm deep x 2.2 mm wide, machined along the surface of the cylinder parallel its long axis at 1.0 cm increments. Plastic needles (15 gauge) were inserted into the grooves along the surface of the acrylic cylinder and held in place with heat shrink tubing. The applicator was easily inserted and positioned without anesthesia. Standard low dose rate 192Ir ribbons were inserted into the plastic needles after positioning the applicator in the vagina. Results: Construction of this applicator system requires a few weeks notice and approximately $150. Fabrication of the grooved cylinder is a routine task for a workshop with a milling machine. A step-by-step description of how to construct and use the applicator is provided along with the telephone numbers of commercial vendors to call to order all necessary materials. Conclusion: This article describes a simple, inexpensive method for constructing a customized vaginal applicator that can be used to treat a limited area of the vagina with intracavitary brachytherapy.

1997-03-01

78

[The use of vagina and percutaneous surgery in stress urinary incontinence: description, foundations, and indications  

UK PubMed Central (United Kingdom)

Our modifications to the Stamey, Guittes and Raz procedures are described and discussed. Our own experience of seven years and the experience reported by other authors in the world literature demonstrate the usefulness of the vagina in endoscopic percutaneous surgical treatment of female stress urinary incontinence. The complication rate is reduced, efficacy is enhanced and different alternatives are possible depending on the anatomic and functional characteristics of each case.

Orozco Fariñas R; Osorio Acosta V; Capdevila Viciedo D; Pedro Silva I; García García A

1993-12-01

79

Effect of prolonged use of high dose of tibolone on the vagina of ovariectomized rats  

Science.gov (United States)

The aim of this study was evaluate the effect of prolonged use of high dose of tibolone on the vagina of ovariectomized rats. Bilateral ovariectomy was performed on 14 rats weighing 250 g. Thirty days later, vaginal smears were collected verifying the menopause status by anoestrus cytology. Rats were divided randomly into groups: experimental rats (n = 9) received 1 mg tibolone/day orally and control rats (n = 6) received placebo (carboxymethylcellulose). After 150 days, all rats were sedated and euthanized by cervical displacement. The vagina was removed, fixed in 10% buffered formalin, sampled and processed for paraffin embedding. Histological sections were stained with haematoxylin and eosin, picrosirius red, periodic acid Schiff (PAS) and PAS-diastase, and Weigert's resorcin–fuchsin. Cell proliferation was analysed by immunohistochemistry to detect Ki67. Histomorphometric analyses were performed for epithelial thickness, per cent area of collagen fibres and blood vessels, mast cells and Ki67-positive nuclei per mm of basal membrane. Means and standard error of means were calculated, and data were compared using the Mann–Whitney test, with significance level at P < 0.05. In the vagina, epithelial thickness, number of Ki67-positive nuclei per mm of basal membrane, number of vessels and number of mast cells were significantly higher in the tibolone group when compared with the control group. Furthermore, the content of glycogen and glycoproteins in the vaginal epithelium was modified by tibolone. Tibolone administered in high dose and for a long period has a trophic effect, reversing vaginal atrophy, and has no dysplastic or neoplastic effect in the vagina of ovariectomized rats.

Henriques, Helene Nara; de Carvalho, Ana Carolina Bergmann; Filho, Porphirio Jose Soares; Pantaleao, Jose Augusto Soares; Guzman-Silva, Maria Angelica

2011-01-01

80

Verrucous carcinoma of the cervix and vagina treated by radiation therapy  

International Nuclear Information System (INIS)

[en] Seven cases of verrocous carcinoma of the uterine cervix (five) and vagina (two) were reviewed. Four of the five patients managed primarily with radiation therapy have survived a median of 10 years. Of the two patients managed primarily with surgery, one experienced recurrence and was then successfully treated with radiation therapy; the other died of metastatic carcinoma. No anaplastic transformation of lesions or distant metastases occurred in the patients treated with radiation therapy. Human papilloma virus was isolated in two patients

1986-12-05

 
 
 
 
81

Use of Cavitron Ultrasonic Surgical Aspirator (CUSA) for palliative resection of recurrent gynecologic malignancies involving the vagina.  

UK PubMed Central (United Kingdom)

Three patients with recurrent ovarian and/or endometrial cancer involving the vagina underwent successful palliative surgical debulking with the Cavitron Ultrasonic Surgical Aspirator (CUSA). Its use minimized bleeding and accomplished temporary control of the tumor.

Deppe G; Malviya VK; Malone JM Jr

1989-01-01

82

Ectodermal structures within the uterine cervix and vagina: report of a series of cases.  

UK PubMed Central (United Kingdom)

Ectodermal structures, in the form of sebaceous glands and hair follicles, are extremely rare within the cervix and vagina. We describe the clinicopathologic findings in 11 cases (10 cervix, 1 vagina) with a view to exploring the histogenesis of this unusual phenomenon. The cases occurred in patients aged 33 to 71. In 10 of the cases, sebaceous glands were present that were associated with hair follicle-like structures in 3 cases forming pilosebaceous units. In the other case, hair follicle- and sweat gland-like structures were present; the latter have not been previously described in the cervix. The ectodermal structures were usually either attached to the basal layer of the surface squamous epithelium or lay "free" within the superficial stroma, although in 1 case sebaceous glands were located within the squamous epithelium. The squamous epithelium overlying the ectodermal structures typically exhibited hyperkeratosis. Although we were unable to definitively resolve the debate as to whether ectodermal structures within the cervix and vagina represent misplaced embryonal tissue and a true heterotopia or a "metaplastic" process, we favor the latter as a response to prolonged irritation or chronic injury.

Brady A; McCluggage WG

2013-11-01

83

Ectodermal structures within the uterine cervix and vagina: report of a series of cases.  

Science.gov (United States)

Ectodermal structures, in the form of sebaceous glands and hair follicles, are extremely rare within the cervix and vagina. We describe the clinicopathologic findings in 11 cases (10 cervix, 1 vagina) with a view to exploring the histogenesis of this unusual phenomenon. The cases occurred in patients aged 33 to 71. In 10 of the cases, sebaceous glands were present that were associated with hair follicle-like structures in 3 cases forming pilosebaceous units. In the other case, hair follicle- and sweat gland-like structures were present; the latter have not been previously described in the cervix. The ectodermal structures were usually either attached to the basal layer of the surface squamous epithelium or lay "free" within the superficial stroma, although in 1 case sebaceous glands were located within the squamous epithelium. The squamous epithelium overlying the ectodermal structures typically exhibited hyperkeratosis. Although we were unable to definitively resolve the debate as to whether ectodermal structures within the cervix and vagina represent misplaced embryonal tissue and a true heterotopia or a "metaplastic" process, we favor the latter as a response to prolonged irritation or chronic injury. PMID:24071877

Brady, Aidan; McCluggage, W Glenn

2013-11-01

84

Longitudinal qPCR study of the dynamics of L. crispatus, L. iners, A. vaginae, (sialidase positive) G. vaginalis, and P. bivia in the vagina.  

UK PubMed Central (United Kingdom)

BACKGROUND: To obtain more detailed understanding of the causes of disturbance of the vaginal microflora (VMF), a longitudinal study was carried out for 17 women during two menstrual cycles. METHODS: Vaginal swabs were obtained daily from 17 non-pregnant, menarchal volunteers. For each woman, Gram stains were scored, the quantitative changes of 5 key vaginal species, i.e. Atopobium vaginae, Lactobacillus crispatus, L. iners, (sialidase positive) Gardnerella vaginalis and Prevotella bivia were quantified with qPCR and hydrogen-peroxide production was assessed on TMB+ agar. RESULTS: Women could be divided in 9 subjects with predominantly normal VMF (grades Ia, Ib and Iab, group N) and 8 with predominantly disturbed VMF (grades I-like, II, III and IV, group D). VMF was variable between women, but overall stable for most of the women. Menses were the strongest disturbing factor of the VMF. L. crispatus was present at log7-9 cells/ml in grade Ia, Iab and II VMF, but concentrations declined 100-fold during menses. L. crispatus below log7 cells/ml corresponded with poor H(2)O(2)-production. L. iners was present at log 10 cells/ml in grade Ib, II and III VMF. Sialidase negative G. vaginalis strains (average log5 cells/ml) were detected in grade I, I-like and IV VMF. In grade II VMF, predominantly a mixture of both sialidase negative and positive G. vaginalis strains (average log9 cells/ml) were present, and predominantly sialidase positive strains in grade III VMF. The presence of A. vaginae (average log9 cells/ml) coincided with grade II and III VMF. P. bivia (log4-8 cells/ml) was mostly present in grade III vaginal microflora. L. iners, G. vaginalis, A. vaginae and P. bivia all increased around menses for group N women, and as such L. iners was considered a member of disturbed VMF. CONCLUSIONS: This qPCR-based study confirms largely the results of previous culture-based, microscopy-based and pyrosequencing-based studies.

Santiago GL; Tency I; Verstraelen H; Verhelst R; Trog M; Temmerman M; Vancoillie L; Decat E; Cools P; Vaneechoutte M

2012-01-01

85

Melanosis of the vagina and human papillomavirus infection, an uncommon pathology: Case Report/ Melanosis de la vagina e infección por virus del papiloma humano, una patología poco común: Reporte de un Caso  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Las lesiones melanóticas de la vagina son infrecuentes. y Solo pocos casos han sido reportados. Se presenta el caso de una mujer de 34 años quien es referida con diagnóstico de una Neoplasia Intraepitelial Vaginal 1. Al examen ginecológico, se encontraron dos áreas hiperpigmentadas en la vagina. La exploración colposcópica del cuello uterino y vagina reveló la presencia de una lesión aceto-blanca en la pared lateral derecha del tercio superior de la vagina. Muest (more) ras de biopsias fueron tomadas en dichas áreas. El estudio histológico reportó una melanosis de la vagina y una infección por el virus del Papiloma Humano (VPH). Se realizó un panel de estudio inmunohistoquímico de marcadores epiteliales en las muestras vaginales: tales como citoqueratina AE1/AE3 y antígeno epitelial de membrana; marcador mesenquimal: vimentin; marcadores melanóticos: proteina S-100 y HMB45 (Human Melanoma Black); marcadores de proliferación celular: antígeno de proliferación nuclear (PCNA), y la oncoproteína P-53. Se realizó Hibridización In Situ para establecer los tipos de alto (16, 18, 31, 45) y bajo (6, 11) riesgo de VPH en las muestras vaginales. Los marcadores CK, EMA y Vimentin fueron 2+. Los marcadores melanótico, el HMB45 y el S100, y el PCNA fueron 1+ en la capa basal. P-53 fue negativo. El tejido melanótico y la lesión acetoblanca fueron positivos al VPH 6,11. En conclusión, la melanosis vaginal es una patología poco frecuente. Usualmente, se ha reportado en mujeres mayores de 40 años. Presentamos un caso de una melanosis de la vagina infectada con un tipo de VPH de bajo riesgo en una mujer joven y una revisión de la literatura. Abstract in english Benign melanotic lesions of the vagina are uncommon and only a few cases have been reported in the literature. A 34-year-old woman was referred because of a Vaginal Intraepithelial Neoplasia 1 biopsy result. On the gynecological examination, two different hyperpigmented areas were noted in the vagina. The colposcopic visualization of the cervix and vagina found an aceto-white lesion at the right lateral wall of the upper third of the vagina. Biopsies from three areas were (more) taken. Histological study reported a melanosis of the vagina and HPV infection. An immunohistochemical panel of epithelial markers was performed in vaginal samples, such as Cytokeratin AE1/AE3 and epithelial membrane antigen, mesenchymal marker: vimentin; melanocytic makers: protein S-100 and HMB45 (Human Melanoma Black); proliferating cell marker: proliferating cell nuclear antigen (PCNA), and P-53 oncoprotein. High Risk (16, 18, 31, 45) and Low Risk (6, 11) HPV types were studied by In Situ Hybridization using the same vaginal samples. CK, EMA and Vimentin were 2+. Melanocytic markers, HMB45 and S100, and PCNA were 1+ in basal cell layer. P-53 was negative. The melanotic tissue and acetowhite lesion were positives to HPV Types 6,11. In conclusion, melanosis of the vagina is a uncommon benign pathology. Usually, melanosis is present in women over 40 years old. We present a case of melanosis of the vagina in a young woman infected with low-risk HPV types and review the literature.

Núñez-Troconis, José; Delgado, Mariela; González, Gerardo; Rivas, Airiaudis; Molero, Katherine

2011-09-01

86

Melanosis of the vagina and human papillomavirus infection, an uncommon pathology: Case Report Melanosis de la vagina e infección por virus del papiloma humano, una patología poco común: Reporte de un Caso  

Directory of Open Access Journals (Sweden)

Full Text Available Benign melanotic lesions of the vagina are uncommon and only a few cases have been reported in the literature. A 34-year-old woman was referred because of a Vaginal Intraepithelial Neoplasia 1 biopsy result. On the gynecological examination, two different hyperpigmented areas were noted in the vagina. The colposcopic visualization of the cervix and vagina found an aceto-white lesion at the right lateral wall of the upper third of the vagina. Biopsies from three areas were taken. Histological study reported a melanosis of the vagina and HPV infection. An immunohistochemical panel of epithelial markers was performed in vaginal samples, such as Cytokeratin AE1/AE3 and epithelial membrane antigen, mesenchymal marker: vimentin; melanocytic makers: protein S-100 and HMB45 (Human Melanoma Black); proliferating cell marker: proliferating cell nuclear antigen (PCNA), and P-53 oncoprotein. High Risk (16, 18, 31, 45) and Low Risk (6, 11) HPV types were studied by In Situ Hybridization using the same vaginal samples. CK, EMA and Vimentin were 2+. Melanocytic markers, HMB45 and S100, and PCNA were 1+ in basal cell layer. P-53 was negative. The melanotic tissue and acetowhite lesion were positives to HPV Types 6,11. In conclusion, melanosis of the vagina is a uncommon benign pathology. Usually, melanosis is present in women over 40 years old. We present a case of melanosis of the vagina in a young woman infected with low-risk HPV types and review the literature.Las lesiones melanóticas de la vagina son infrecuentes. y Solo pocos casos han sido reportados. Se presenta el caso de una mujer de 34 años quien es referida con diagnóstico de una Neoplasia Intraepitelial Vaginal 1. Al examen ginecológico, se encontraron dos áreas hiperpigmentadas en la vagina. La exploración colposcópica del cuello uterino y vagina reveló la presencia de una lesión aceto-blanca en la pared lateral derecha del tercio superior de la vagina. Muestras de biopsias fueron tomadas en dichas áreas. El estudio histológico reportó una melanosis de la vagina y una infección por el virus del Papiloma Humano (VPH). Se realizó un panel de estudio inmunohistoquímico de marcadores epiteliales en las muestras vaginales: tales como citoqueratina AE1/AE3 y antígeno epitelial de membrana; marcador mesenquimal: vimentin; marcadores melanóticos: proteina S-100 y HMB45 (Human Melanoma Black); marcadores de proliferación celular: antígeno de proliferación nuclear (PCNA), y la oncoproteína P-53. Se realizó Hibridización In Situ para establecer los tipos de alto (16, 18, 31, 45) y bajo (6, 11) riesgo de VPH en las muestras vaginales. Los marcadores CK, EMA y Vimentin fueron 2+. Los marcadores melanótico, el HMB45 y el S100, y el PCNA fueron 1+ en la capa basal. P-53 fue negativo. El tejido melanótico y la lesión acetoblanca fueron positivos al VPH 6,11. En conclusión, la melanosis vaginal es una patología poco frecuente. Usualmente, se ha reportado en mujeres mayores de 40 años. Presentamos un caso de una melanosis de la vagina infectada con un tipo de VPH de bajo riesgo en una mujer joven y una revisión de la literatura.

José Núñez-Troconis; Mariela Delgado; Gerardo González; Airiaudis Rivas; Katherine Molero

2011-01-01

87

Androgen receptor expression in the human vagina under different physiological and treatment conditions.  

UK PubMed Central (United Kingdom)

Recent data report an important role of testosterone (T) in modulating female sexual responses, but little is known about the expression and distribution of androgen receptor (AR) in the human vagina. Therefore, the aims of our study were to evaluate the expression of AR in the human vagina in premenopausal (PrM) and menopausal (M) women and in T-treated women. Vaginal biopsies were obtained from PrM and postmenopausal women and from women with gender identity disorder (female to male (FtM)) receiving exogenous T. AR gene and protein expression levels in vaginal tissues were determined by real-time PCR and western blot analysis, respectively, whereas the localization of AR in vaginal mucosa and stroma was performed by immunohistochemistry. ARs were detected by immunostaining both in the mucosa and stroma. In vaginal mucosa, AR density score decreases with age but does not change with T administration. In stromal tissue, AR density score does not change with age but significantly increases with T administration (P<0.01). AR protein expression was significantly increased in FtM subjects (P<0.001). The expression of AR messenger RNA (mRNA) evaluated by Real-time PCR showed a significantly higher mRNA expression in FtM versus M patients (P<0.01) and in PrM versus M subjects (P<0.05). In conclusion, we found AR protein and mRNA expression both in the epithelium and stroma of the human vagina in all groups of women. A negative correlation exists between age and AR expression in the vaginal mucosa. T administration increases AR expression in both the mucosa and stroma.

Baldassarre M; Perrone AM; Giannone FA; Armillotta F; Battaglia C; Costantino A; Venturoli S; Meriggiola MC

2013-01-01

88

Deterioration in biomechanical properties of the vagina following implantation of a high-stiffness prolapse mesh.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To define the impact of prolapse mesh on the biomechanical properties of the vagina by comparing the prototype Gynemesh PS (Ethicon) to two new-generation lower stiffness meshes, SmartMesh (Coloplast) and UltraPro (Ethicon). DESIGN: A study employing a nonhuman primate model. SETTING: University of Pittsburgh, PA, USA. POPULATION: Forty-five parous rhesus macaques. METHODS: Meshes were implanted via sacrocolpopexy after hysterectomy and compared with sham. Because its stiffness is highly directional, UltraPro was implanted in two directions: UltraPro Perpendicular (less stiff) and UltraPro Parallel (more stiff), with the indicated direction referring to the position of the blue orientation lines relative to the longitudinal axis of the vagina. The mesh-vaginal complex (MVC) was excised in toto after 3 months. MAIN OUTCOME MEASURES: Active mechanical properties were quantified as the contractile force generated in the presence of 120 mmol/l KCl. Passive mechanical properties (a tissue's ability to resist an applied force) were measured using a multiaxial protocol. RESULTS: Vaginal contractility decreased by 80% following implantation with the Gynemesh PS (P = 0.001), 48% after SmartMesh (P = 0.001), 68% after UltraPro Parallel (P = 0.001) and was highly variable after UltraPro Perpendicular (P = 0.16). The tissue contribution to the passive mechanical behaviour of the MVC was drastically reduced for Gynemesh PS (P = 0.003), but not for SmartMesh (P = 0.9) or UltraPro independent of the direction of implantation (P = 0.68 and P = 0.66, respectively). CONCLUSIONS: Deterioration of the mechanical properties of the vagina was highest following implantation with the stiffest mesh, Gynemesh PS. Such a decrease associated with implantation of a device of increased stiffness is consistent with findings from other systems employing prostheses for support.

Feola A; Abramowitch S; Jallah Z; Stein S; Barone W; Palcsey S; Moalli P

2013-01-01

89

The relative efficacy of HDR and LDR interstitial brachytherapy in squamous cell carcinoma of vagina  

International Nuclear Information System (INIS)

Introduction: Beginning in 1982 we performed low dose rate (LDR) interstitial template brachytherapy (ISTB) for carcinoma of the vagina. High dose rate (HDR) remote afterloading has been used exclusively since 1991. We compare the results LDR and HDR brachytherapy. Material and Methods: Between 1982 and 1994, 30 patients with primary squamous cell carcinoma of vagina received external beam radiotherapy (EBRT) and brachytherapy. The AJCC stage distribution was 3 stage I, 25 stage II, and 2 stage III. The average central pelvic EBRT dose was 35 Gy. Pelvic side wall EBRT doses ranged from 45 to 50.4 Gy. Nineteen patients had LDR treatment; 3 intracavitary brachytherapy (ICB) and 16 ISTB. Eleven patients had HDR treatment; 2 ICB and 9 ISB. The average dose delivered by LDR was 41.2 Gy usually in 2 fractions, and by HDR 32.5 Gy in 6 fractions of 500-550 cGy. Local failures were confirmed pathologically. The absolute survival (AS) and relapse-free survival (RFS) were calculated using Kaplan-Meier method and compared with logrank statistics. Results: The mean follow-up was 77 months for LDR and 23 months for HDR. Local and regional control was achieved in 90% (27/30) of the patients. Three year AS was 84% and RFS was 87%. There was no significant difference between LDR and HDR in AS, RFS or local-regional control, (log rank p=0.85, p=0.12 and p=0.35 respectively). The single HDR local failure presented in a patient with extensive stage II disease who declined ISTB. There were fewer complications following HDR. The 1 case of extensive vaginal necrosis and the 3 cases of rectovaginal fistula that required surgery occurred only with LDR brachytherapy. Discussion: Excellent local and regional control of carcinoma of the vagina can be achieved by administering limited doses of external radiation and brachytherapy. Interstitial template implants are the best means of encompassing paravaginal disease while sparing the adjacent uninvolved normal tissues from high doses of radiation. HDR technology is an effective means of administering high uniform tumor doses, maximizes dose control to the bladder and rectum and improves radiation safety. Conclusion: Optimal tumor control and less morbidity at 2 years after treatment can be achieved with HDR-ISTB in squamous carcinoma of the vagina compared to alternative treatments.

1996-01-01

90

Pre leukemic granulocytic sarcoma of vagina. A case report with review of literature.  

Directory of Open Access Journals (Sweden)

Full Text Available Granulocytic sarcoma is an extramedullary tumor of malignant granulocytic progenitor cells, that may precede the onset of acute myeloid leukemia or appear during the leukemic manifestation or blastic crisis of chronic myeloproliferative disorders. We describe a case of granulocytic sarcoma of vagina in a 27 year old woman treated with local radiotherapy. After seven months of follow up she developed acute myeloid leukemia. The case has been presented in view of its rarity and discussed in light of the available literature.

Lakshminarasimhan S; Doval D; Rajashekhar U; Mukherjee G; Kannan V; Devi L; Bapsy P

1996-01-01

91

Bilateral Single Ectopic Ureters Draining Into a Grossly Dilated Vagina in an Adolescent Female  

Science.gov (United States)

A 16-year-old female presented with dribbling of urine along with voluntary voiding since birth. Renal imaging revealed hydroureteronephrosis on the right side; the uterus and ovary were normal. A radionuclide scan showed a left nonfunctional kidney. On cystovaginoscopy, the urethra was shown to be normal and the urinary bladder was tubular with small capacity and an absent trigone. Although the vagina was capacious, no ureteric orifices were found. Computed tomography corroborated the diagnosis of bilateral, single ectopic ureters draining into a grossly dilated vagina. This case is unique because it is a bilateral single-system ureteral ectopia in a completely differentiated female genital tract that presented late in adolescence. To the best of our knowledge, this is the second such ureteral abnormality reported in the literature so far. The patient underwent ileocystoplasty with right ureteric reimplantation and nephroureterectomy for the left nonfunctional kidney, which histopathology showed to be tuberculosis. The patient is continent with cystometric capacity of more than 300 mL.

Mandal, Soumendra Nath; Kamal, Mir Reza; Mukherjee, Satyadip; Das, Ranjit Kumar; Karmakar, Dilip

2013-01-01

92

Morphology, morphometry, histochemistry and lectin histochemistry of the vagina of the plains viscacha (Lagostomus maximus).  

UK PubMed Central (United Kingdom)

The aim of the present work was to describe the morphology of the vagina in Lagostomus maximus and to characterize its epithelial cells using morphometric and histochemical techniques (variations of PAS, Alcian blue and lectin histochemistry). Thirty-five sexually mature adult females were captured in their natural environment during four periods of the year and their genital organs were dissected. The vaginal wall of the viscacha has three tunics: mucosa, muscularis and adventitia or serosa according to the region. The epithelium is stratified in both cranial and caudal regions, but its characteristics vary depending on the physiological state. In anestrous, nonpregnant females have a stratified epithelium of two to three cellular layers with columnar PAS-positive superficial mucous cells. During the follicular phase, the epithelium of the vagina is stratified squamous and cornified. Females at early, middle and term pregnancy have a columnar stratified epithelium with mucous cells. Glycoproteins in the mucous cells were detected using PAS, PA*S, KOH/PA*/BH/PAS; and Alcian blue, pH 0.5, pH 1, pH 2.5 and 0.006 M). Lectin histochemistry showed that UEA-I and RCA-1 lectins reacted strongly or moderately with epithelial cells in all stages analyzed. These results indicate the presence of L-fucose and ?-galactose. Binding with other lectins was variable.

Flamini MA; Díaz AO; Barbeito CG; Portiansky EL

2012-02-01

93

Antibiogram of Group B Streptococci Isolated from the Vagina of Pregnant  

Directory of Open Access Journals (Sweden)

Full Text Available Group B streptococcal (GBS) prevalence varies from place to place; this organism is responsible for serious infections in newborns, such as septicemia and meningitis. The present study was aimed to find out the antibiogram of Group B Streptococci isolated from the vagina of pregnant women who were in the third trimester of pregnancy and toidentify the risk factors for its colonization in vagina. The study was carried out in the Department of Microbiology, M. R. Medical College & Hospital, Gulbarga during a period from January 2007 to December 2007. Two hundred pregnant women who were in the third trimester of pregnancy and attending the antenatal clinics were included in the study. Two low vaginal swabs were taken from each women included in the study and were immediately transported to the laboratory for processing. Direct gram staining was done from one swab and the other swab was inoculated into sheep blood agar plate and incubated at 37ºC for 24-48 hours. Identification of organism was based on gram staining, colony morphology, catalase reaction,Christie Atkins Munch Petersen (CAMP) and Hippurate hydrolysis test.Of the 200 pregnant women screened, 7.5% were colonized by GBS. Incidence of GBS colonization was higher among pregnant women in the third trimester who were 25 years of age and primigravida. All the isolates were sensitive to Ampicillin, Erythromycin and Penicillin but were resistant to Gentamicin and Kanamycin.

Vinay Hajare, *L.H. Madhavi, **H.K.G. Singh

2012-01-01

94

Bilateral single ectopic ureters draining into a grossly dilated vagina in an adolescent female.  

UK PubMed Central (United Kingdom)

A 16-year-old female presented with dribbling of urine along with voluntary voiding since birth. Renal imaging revealed hydroureteronephrosis on the right side; the uterus and ovary were normal. A radionuclide scan showed a left nonfunctional kidney. On cystovaginoscopy, the urethra was shown to be normal and the urinary bladder was tubular with small capacity and an absent trigone. Although the vagina was capacious, no ureteric orifices were found. Computed tomography corroborated the diagnosis of bilateral, single ectopic ureters draining into a grossly dilated vagina. This case is unique because it is a bilateral single-system ureteral ectopia in a completely differentiated female genital tract that presented late in adolescence. To the best of our knowledge, this is the second such ureteral abnormality reported in the literature so far. The patient underwent ileocystoplasty with right ureteric reimplantation and nephroureterectomy for the left nonfunctional kidney, which histopathology showed to be tuberculosis. The patient is continent with cystometric capacity of more than 300 mL.

Mandal SN; Jagadheesan GP; Kamal MR; Mukherjee S; Das RK; Karmakar D

2013-07-01

95

Foreign body in vagina: an uncommon cause of vaginitis in children.  

UK PubMed Central (United Kingdom)

Vaginal discharge in children may result from a variety of causes. A long-standing intra-vaginal foreign body can pose both diagnostic and therapeutic challenges in children. Treatment failure may occur because of alteration of the normal vaginal flora. A 6-year-old girl, who lived with her parents, presented with a foul-smelling, blood-stained vaginal discharge as well as dysuria for 2 years. There was no history of sexual abuse. Initial evaluation that excluded gynecologic examination revealed lower abdominal tenderness. Vaginal swab and urine cultures yielded Staphylococcus aureus sensitive to ceftriaxone only. She was commenced on this antibiotic for 2 weeks, but the discharge persisted, necessitating referral to the gynecologist. Examination under anesthesia by the gynecologist revealed shreds of toilet tissue paper extracted from the vagina and slight excoriations on the wall of the vagina. Vaginal foreign body can present with diverse symptoms. It should be considered in any young female patient presenting with recurrent or persistent vaginal discharge.

Chinawa J; Obu H; Uwaezuoke S

2013-01-01

96

Laparoscopically assisted biomaterial graft for reconstruction in congenital atresia of vagina and cervix.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To report successful treatment by laparoscopically assisted biomaterial graft for reconstruction in patients with congenital atresia of the uterine cervix and vagina. DESIGN: Technique and instrumentations. SETTING: University-based tertiary care hospital. PATIENT(S): An 18-year-old woman with vaginal agenesis and cervical dysgenesis and a 13-year-old woman with vaginal agenesis and cervical agenesis, both patients with a functional uterus. INTERVENTION(S): Creation of a neovagina by vaginal procedure and laparoscopically assisted biomaterial graft for uterovaginal anastomosis was performed in all patients. MAIN OUTCOME MEASURE(S): All surgical findings were carefully reviewed to determine the anatomic characteristics of the malformed cervix. Subsequent follow-up was done by referring physicians. RESULT(S): Uterovaginal continuity was established successfully in both patients, and all of the women were menstruating normally. Granulomatous polyps occurred in one patient, and this condition was successfully managed. At 6-month follow-up, mean vaginal length was 12 cm and ?80% of neovaginal epithelium was iodine positive in both patients. Unimpeded menstrual flow continued after 4 year of follow-up in one patient and 5 years of follow-up in the other patient. CONCLUSION(S): A combined laparoscopic and vaginal procedure with biomaterial graft could be an effective alternative in selected women with atresia of cervix and vagina.

Li M; Zhang Z

2013-09-01

97

Malignant lymphoma of the vagina successfully treated with rituximab, adryamicin, cyclophosphamide, vincristine sulfate, and prednisolone.  

UK PubMed Central (United Kingdom)

PURPOSE: Primary malignant lymphoma of the vagina is extremely rare. The most common histologic subtype is diffuse large B-cell lymphoma (DLBCL). We report a case of vaginal DLBCL successfully treated with chemotherapy consisting of rituximab, adryamicin, cyclophosphamide, vincristine sulfate, and prednisolone (R-CHOP), followed by pelvic irradiation. CASE: A 44-year-old Japanese woman was admitted complaining of atypical genital bleeding and puruloid vaginal discharge. Gynecological examination showed an ulceration of the vaginal wall and a hard mass the size of a goose egg beneath the left vaginal wall, which had infiltrated to the left pelvic wall. The pathological diagnosis based on a punch biopsy taken from the vaginal tumor was non-Hodgkin's lymphoma. Based on immunohistochemical study, the tumor was subclassified as activated B-cell type DLBCL. The patient was diagnosed with Ann Arbor Stage IEA DLBCL and Stage III vaginal cancer, according to the International Federation of Gynecologists and Obstetricians (FIGO) classification system. She was successfully treated by six courses of R-CHOP, followed by radiation therapy. The patient is well without evidence of disease 13 months following the initial treatment. CONCLUSION: Little attention has been paid to the use of rituximab in addition to conventional chemotherapy and the importance of clinical and morphological subgrouping of DLBCL arising in the vagina. The present case indicates that the effects of rituximab on the prognosis of vaginal DLBCL must be evaluated, and that clinical use of immunophenotypic subgrouping should be considered for vaginal DLBCL.

Nasu K; Okamoto M; Nishida M; Takai N; Narahara H

2012-01-01

98

Proliferation of Pasteurella pneumotropica at oestrus in the vagina of rats.  

UK PubMed Central (United Kingdom)

Using a colony of Wistar-Imamichi rats contaminated with P. pneumotropica, the vaginal microflora was qualitatively and quantitatively investigated by swabbing. P. pneumotropica was the most dominant organism in the majority of rats examined. The population of P. pneumotropica and indigenous bacteria increased significantly higher at oestrus than in other oestrous stages. By the vaginal flushing technique changes in the population of P. pneumotropica and total bacteria, and changes in vaginal cell type and bacterial counts adhering to vaginal epithelial cells were consecutively investigated. The populations of P. pneumotropica and total bacteria were maximal at oestrus. The increase was correlated with an increase in cornified non-nucleated cells, with large numbers of adherent Gram-negative coccobacilli. The findings indicate that the vagina is a suitable site for colonization by P. pneumotropica in adult female rats, and that proliferation of P. pneumotropica may be due to increased affinity of the organism for cornified non-nucleated cells.

Yamada S; Baba E; Arakawa A

1983-10-01

99

Role of radiation therapy in the management of primary carcinoma of the vagina  

International Nuclear Information System (INIS)

[en] A retrospective analysis of 88 patients with microscopically proven primary carcinoma of the vagina is presented. All patients were treated between 1957 and 1975 and have been followed for a minimum of 5 years. The technique of treatment, external, intracavitary and interstitial irradiation has been highly integrated and individualized. Several important features could be drawn from the current data: (1) The necessity for individualized radiation treatment to achieve the success, (2) the necessity to subdivide stage II into II A and II B is clearly shown by the 5-year survival data, (3) a relatively low complication rate from the use of high dose combined radiation modalities in higher stages is demonstrated. (Auth.)

1982-01-01

100

Integrated external and interstitial radiation therapy for primary carcinoma of the vagina  

International Nuclear Information System (INIS)

[en] Twenty-seven patients with the diagnosis of primary carcinoma of the vagina were treated by definitive radiotherapy. Twenty-three patients received a combination of external and interstitial iridium-192 implant irradiation and four patients received only interstitial irradiation. Twenty-one patients had squamous cell carcinoma and six had adenocarcinoma. All patients were staged according to the FIGO classification. More than 70% of patients had relatively advanced local disease and conventional intracavitary irradiation was unsuitable. Local tumor control was observed in 85% (23 of 27 patients), and 56% of the patients remain alive and free of disease for a median follow-up period of 50 months to a maximum follow-up period of 84 months. Fifteen percent of the patients suffered from treatment-related complications

1983-01-01

 
 
 
 
101

Do Atopobium vaginae, Megasphaera sp. and Leptotrichia sp. change the local innate immune response and sialidase activity in bacterial vaginosis?  

UK PubMed Central (United Kingdom)

OBJECTIVES: To investigate if the participation of Atopobium vaginae, Megasphaera sp. and Leptotrichia sp. in the bacterial community of bacterial vaginosis (BV) is associated with distinct patterns of this condition. METHODS: In this cross-sectional controlled study, 205 women with BV and 205 women with normal flora were included. Vaginal rinsing samples were obtained for measuring the levels of pro-inflammatory cytokines and bacterial sialidases. Real-time PCR was used to quantify the BV-associated bacteria and to estimate the total bacterial load using the 16S rRNA. Principal component analysis (PCA) using the measured parameters was performed to compare the BV samples with lower and higher loads of the species of interest. RESULTS: Higher bacterial load (p<0.001), levels of interleukin 1-? (p<0.001) and sialidase activity (p<0.001) were associated with BV. Women with BV and higher relative loads of A vaginae, Megasphaera sp. and Leptotrichia sp. presented increased sialidase activity, but unchanged cytokine levels. PCA analysis did not indicate a different pattern of BV according to the loads of A vaginae, Megasphaera sp. and Leptotrichia sp. CONCLUSIONS: Greater participation of A vaginae, Megasphaera sp. and Leptotrichia sp. in vaginal bacterial community did not indicate a less severe form of BV; moreover, it was associated with increased sialidase activity.

Marconi C; Donders GG; Parada CM; Giraldo PC; da Silva MG

2013-03-01

102

B-cell lymphoma of the vagina occurring after treatment for classic Hodgkin lymphoma: a case report and literature review.  

UK PubMed Central (United Kingdom)

Malignant lymphomas of the female genital tract are very uncommon, and the development of a diffuse large B-cell lymphoma involving the vagina following treatment for classic Hodgkin lymphoma is extremely rare. Clinically and morphologically, this entity represents a challenge. We herein report such a case with liquid-based Pap test and tissue biopsy findings.

Chen X; Hamele-Bena D; Fai Chow K; Hawver M; He H; Raphael B; Jain S; Wright TC

2013-05-01

103

Atypical smooth muscle tumor of the vagina--a pediatric case report and review of the literature.  

Science.gov (United States)

Vaginal tumors in children are uncommon. This report describes the rare case of an atypical smooth muscle tumor arising from the vagina in a pediatric patient managed with tumor resection, vaginal reconstruction, and continent urinary diversion. We also discuss a review of the literature and a brief report detailing our experience with pediatric vaginal tumors. PMID:23701791

Crowley, Helena M; Mohamed, Ahmad; Baker, Peter; Jayanthi, Venkata R; Ranalli, Mark; Aldrink, Jennifer H

2013-05-01

104

The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina) – phenotypic manifestations and genetic approaches  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome affects at least 1 out of 4500 women and has for a long time been considered as a sporadic anomaly. Congenital absence of upper vagina and uterus is the prime feature of the disease which, in addition, is often found associated with unilateral renal...

Guerrier, Daniel; Mouchel, Thomas; Pasquier, Laurent; Pellerin, Isabelle

105

The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina) – phenotypic manifestations and genetic approaches  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome affects at least 1 out of 4500 women and has for a long time been considered as a sporadic anomaly. Congenital absence of upper vagina and uterus is the prime feature of the disease which, in addition, is often found associated wi...

Guerrier Daniel; Mouchel Thomas; Pasquier Laurent; Pellerin Isabelle

106

Reconstruction of the anus, rectovaginal septum, and distal part of the vagina after postirradiation necrosis. Report of a unique case  

International Nuclear Information System (INIS)

Successful repair of postirradiation total loss of the anal sphincters, rectovaginal septum, and distal part of the vagina is reported. Gracilis muscle flap was used as a substitute sphincter. Part of the muscle was wrapped-up in a split skin graft. To the authors' knowledge, this is the first report on new application of gracilis muscle and split skin graft in perineal reconstruction

1988-01-01

107

Resectoscopic treatment of uterus didelphys with unilateral imperforate vagina complicated by hematocolpos and hematometra: case report.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To describe a technique for treating hematocolpos and hematometra in patients with uterus didelphys and unilateral imperforate vagina involving the use of resectoscopy under ultrasonographic control. DESIGN: Case report. SETTING: University hospital. PATIENT(S): A 13-year-old girl with uterus didelphys with unilateral hematometra, hematocolpos, and ipsilateral renal agenesis. The girl complained of severe abdominal pain, which appeared with each of her menses. INTERVENTION(S): The intervention was performed by a vaginoscopic approach to preserve the integrity of the hymen. The first incision on the vaginal wall was performed in correspondence with the hematocolpos under continuous ultrasonographic guidance with the use of a straight resectoscopic loop. Resection of the vaginal septum was continued with the use of an angled resectoscopic loop until almost complete excision of the septum was achieved. MAIN OUTCOME MEASURE(S): Clinical, echographic, and vaginoscopic findings before the operation and 2 and 6 months after the operation. RESULT(S): The surgical procedure was easy to perform. Almost complete excision of the septum was achieved with just a few passages of the resectoscope. Complete drainage of both the hematocolpos and the hematometra was confirmed by ultrasonography. The postoperative period was completely uneventful. Clinical and vaginoscopic evaluations 6 months after the operation confirmed the integrity of the hymen, the complete resolution of clinical symptoms, and the persistence of a large communication between the two vaginas. CONCLUSION(S): Resectoscopic excision under ultrasonographic guidance of the vaginal septum in a girl with uterus didelphys with unilateral hematometra and hematocolpos was effective and easy to perform, and it fully respected the integrity of the reproductive system.

Cicinelli E; Romano F; Didonna T; Schonauer LM; Galantino P; Di Naro E

1999-09-01

108

Primary squamous cell carcinoma of the vagina: Prognostic factors, treatment patterns, and outcomes.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Primary squamous cell carcinoma (SCCA) of the vagina is a rare malignancy with limited data to guide treatment. We evaluated prognostic factors and outcomes for patients with primary vaginal SCCA treated with definitive radiation therapy at a single institution. METHODS: A retrospective analysis was performed on patients treated for primary vaginal SCCA from 1959 to 2011. RESULTS: Ninety-one patients with primary vaginal SCCA were treated with definitive radiation therapy. Thirty-eight patients had FIGO stage I, 28 stage II, 13 stage III, and 12 stage IV disease. The mean total dose was 70.1Gy. Two-year overall survival (OS), locoregional control rate (LRC), and distant metastasis-free survival by stage were, respectively: stage I: 96.2%, 80.6%, 87.5%; stage II: 92.3%, 64.7%, 84.6%; stage III: 66.6%, 44.4%, 50.0%; and stage IV: 25.0%, 14.3%, 25.0%. Treatment with total dose over 70Gy was associated with improved OS (p=0.0956) and LRC (p=0.055). There was a significant difference in median dose received by patients who developed grade 3/4 toxicity compared to those who did not (82.9Gy versus 70.0Gy, p=0.0019). None of the 10 patients treated with IMRT experienced locoregional recurrence or grade 3/4 toxicity. Tumor size larger than 4cm was associated with worse OS (p=0.0034) and LRC (p=0.006). CONCLUSIONS: Our analysis suggests that the optimal dose for definitive treatment of SCCA of the vagina lies between 70 and 80Gy. Treatment with IMRT may allow for dose escalation with reduced toxicity and excellent LRC. Tumor size over 4cm is associated with inferior outcomes and may require additional treatment modalities.

Hiniker SM; Roux A; Murphy JD; Harris JP; Tran PT; Kapp DS; Kidd EA

2013-11-01

109

The oophorectomy effect on Walker 256 tumor inoculated into the vagina and uterine cervix of female rats Efeito da ooforectomia no tumor de Walker 256 inoculado em vagina e colo de útero de ratos fêmeas  

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Full Text Available PURPOSE: Verify the effect of oophorectomy on the evolution of the Walker 256 tumor inoculated into the vagina and cervix of female rats. METHODS: Ten Wistar, female rats were used, distributed into two groups with 05 animals each: Tumor group (TG): Rats inoculated with Walker 256 tumor; Oophorectomy group (OG): oophorectomized rats inoculated with Walker 256 tumor. The day before the tumor vaginal inoculation, acetic acid was inoculated into the vaginas of both groups of rats; the following day, the vaginal walls were scarified with an endocervix brush, and then Walker 256 tumor was inoculated. After 12 days, the tumor was removed together with the vagina and uterine horns for macro and microscopic analyses. The data were submitted to statistical analyses. RESULTS: There was no statistical difference between the two groups; however it was observed that the behavior of tumor growth on the OG group presented greater invasion, compromising the uterine horns. CONCLUSION: The results of the study on the GO group presented a macroscopic behavior different from the TG group, however, both of them presented similar development in terms of tumor mass.OBJETIVO: Verificar o efeito da ooforectomia à inoculação do tumor de Walker 256 em vagina e colo de útero de ratas. MÉTODOS: Foram utilizadas 10 ratas Wistar, fêmeas, virgens, adultas, distribuídas em dois grupos de estudo com 05 animais cada: grupo tumor (GT): ratas inoculadas com tumor de Walker 256, e grupo Ooforectomia (GO): ratas ooforectomizadas e inoculadas com tumor de Walker 256. No dia anterior à inoculação vaginal do tumor, foram inoculados 0,3ml de ácido acético na vagina das ratas de ambos os grupos; no dia seguinte, foi realizada a escarificação da parede vaginal com uma escova de endocérvice e inoculado tumor de Walker 256. Após 12 dias, foi removido o tumor em bloco com vagina e cornos uterinos para análise macro e microscópica. Os dados foram submetidos à análise estatística. RESULTADOS: Não houve diferença estatística entre os dois grupos; no entanto, notou-se que o comportamento de crescimento do tumor no grupo GO apresentou maior invasividade em extensão, comprometendo cornos uterinos. CONCLUSÃO: Observou-se que o grupo GO apresentou comportamento macroscópico diferente ao grupo GT, no entanto, em termos totais de massa tumoral ambos apresentam desenvolvimento similar.

Nara Macedo Botelho Brito; Rita de Kássia Vidigal Carvalho; Lia Tavares de Moura Brasil Matos; Rodolfo Costa Lobato; Rosângela Baía Brito

2009-01-01

110

Experimental inoculation model of Walker 256 carcinoma into vagina and cervix uteri of female rats Modelo experimental de Tumor de Walker 256 em vagina e colo de útero de ratas  

Directory of Open Access Journals (Sweden)

Full Text Available PURPOSE: To establish an inoculation model of Walker 256 carcinoma on cervix uteri and vagina of rats. METHODS: Fifteen female rats were used, and assigned to three groups each one with five rats: group A - rats with 4x10(6) cells of Walker 256 carcinoma without acid acetic inoculation; group B - rats with 2x10(6) cells of Walker 256 carcinoma with acid acetic inoculation and group C: rats with 4x10(6) cells of Walker 256 carcinoma with acid acetic inoculation. The day before tumor cells inoculation the rats from groups B and C were anaesthetized with diethylether and 0,3 ml of acetic acid was inoculated into their vaginas. Tumor cell inoculation into the vagina and cervix was done under general anesthesia with diethylether. Then a endocervical brush was used to scrape the vaginal wall and after that 0,3 ml of the liquid containing tumor cells was inoculated on the vagina and cervix. For the tumor analysis, animals were euthanized at day 12 following tumor cell implantation by an excessive inhalation of diethylether. Tumor was resected entirely and weighed and the tumors were then sectioned and counter stained with hematoxylin and eosin for histopathologic evaluation. It was also calculated the percentage of tumor equivalent to the body weight by the formula: P= tumor weight / body weight x 100. Data were analyzed by one-way analysis of variance - ANOVA. P values OBJETIVO: Estabelecer um modelo de inoculação de Tumor de Walker 256 em vagina e colo de útero de ratas. MÉTODOS: Foram utilizadas 15 ratas fêmeas, virgens, adultas, pesando entre 200-250g, distribuídas em três grupos de estudo com cinco animais cada: grupo A (GA): ratas com tumor de Walker 256 em concentração de 4x10(6) sem ácido acético; grupo B (GB): ratas com tumor de Walker 256 em concentração de 2x10(6) células com ácido acético; grupo C (GC): ratas com tumor de Walker 256 em concentração de 4x10(6) células com ácido acético. No dia anterior à inoculação do tumor, foi realizada a inoculação de 0,3 ml de ácido acético a 10% na vagina das ratas de GB e GC; no dia seguinte, tanto estas como as ratas do grupo GA foram anestesiadas, feita a escarificação da parede vaginal com uma escova de endocérvice e inoculado 0,3ml de tumor na concentração de 4x10(6) células nos grupos GA e GC e 2x10(6) células no grupo GB. Após 12 dias, foi realizada a eutanásia e removido o tumor em bloco com vagina e cornos uterinos para análise, sendo pesado e averiguado seu volume e calculado as relações entre o seu peso e o peso final da rata e o seu volume e o peso final da rata. Os dados foram colhidos e submetidos à análise estatística pelo método ANOVA (um critério). RESULTADOS: A pega em GB e GC foi 100% e em GA 20%. Não houve diferença estatística entre as médias obtidas entre GB e GC. CONCLUSÃO: De acordo com a metodologia utilizada, o modelo de tumor de Walker 256 na vagina apresenta pega de 100% quando associado a ácido acético e não há diferença de comportamento com a inoculação de 4x10(6)ou 2x10(6) células.

Nara Macedo Botelho Brito; Marcus Vinicius Henriques Brito; Rita de Kássia Vidigal Carvalho; Lia Tavares de Moura Brasil Matos; Thiago Sousa Veloso; Diego Matos de Vasconcelos; Rosângela Baía Brito

2007-01-01

111

La vagina dentada: una interpretación de la Estela 25 de Izapa y las guacamayas del juego de pelota de Copán/ The dented vagina: an interpretation for Stela 25 of Izapa and ballcourt macaws of Copan  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Las aves representadas en la Estela 25 de Izapa y el juego de pelota de Copán forman el punto de partida para un examen del tema mitológico de la vagina dentada en Mesoamérica, y sus expresiones en el arte y la narrativa. Un amplio conjunto de narraciones mitológicas recopiladas en México y Guatemala sirve como base para un examen de la historia de Siete Guacamayo en el Popol Vuh, la cual se interpreta como una variante de un mito ampliamente difundido, relacionado c (more) on el origen del Sol y la Luna. La identificación de asuntos comunes, entre ellos el de la vagina dentada, refuerza la relación entre el mito del Popol Vuh y las representaciones de Izapa y Copán. A la vez, revela detalles poco conocidos sobre el simbolismo sexual presente en los mitos cosmogónicos mesoamericanos. Abstract in english The birds represented at Stela 25 of Izapa and Copan ball court are the starting point for the analysis of the mythological topic focused on the vagina dentata in Ancient Mesoamerica, as well as their expressions on art and narrative. A large body of mythological narratives is used as a basis for the examination of the "Siete Guacamayo" story included in the Popol Vuh, which is interpreted as part of a widely extended myth related with the creation of the Sun and the Moon (more) . The identification of common issues, as the vagina dentata topic, strengthens the links between the Popol Vuh myth and the Izapa and Copan representations. It also reveals less known details on the sexual symbolism included in the Mesoamerican cosmogonic myths.

Chinchilla Mazariegos, Oswaldo

2010-01-01

112

La vagina dentada: una interpretación de la Estela 25 de Izapa y las guacamayas del juego de pelota de Copán The dented vagina: an interpretation for Stela 25 of Izapa and ballcourt macaws of Copan  

Directory of Open Access Journals (Sweden)

Full Text Available Las aves representadas en la Estela 25 de Izapa y el juego de pelota de Copán forman el punto de partida para un examen del tema mitológico de la vagina dentada en Mesoamérica, y sus expresiones en el arte y la narrativa. Un amplio conjunto de narraciones mitológicas recopiladas en México y Guatemala sirve como base para un examen de la historia de Siete Guacamayo en el Popol Vuh, la cual se interpreta como una variante de un mito ampliamente difundido, relacionado con el origen del Sol y la Luna. La identificación de asuntos comunes, entre ellos el de la vagina dentada, refuerza la relación entre el mito del Popol Vuh y las representaciones de Izapa y Copán. A la vez, revela detalles poco conocidos sobre el simbolismo sexual presente en los mitos cosmogónicos mesoamericanos.The birds represented at Stela 25 of Izapa and Copan ball court are the starting point for the analysis of the mythological topic focused on the vagina dentata in Ancient Mesoamerica, as well as their expressions on art and narrative. A large body of mythological narratives is used as a basis for the examination of the "Siete Guacamayo" story included in the Popol Vuh, which is interpreted as part of a widely extended myth related with the creation of the Sun and the Moon. The identification of common issues, as the vagina dentata topic, strengthens the links between the Popol Vuh myth and the Izapa and Copan representations. It also reveals less known details on the sexual symbolism included in the Mesoamerican cosmogonic myths.

Oswaldo Chinchilla Mazariegos

2010-01-01

113

Reproductive outcome following resectoscope metroplasty in women having a complete uterine septum with double cervix and vagina.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate reproductive outcomes in women with complete uterine septum with double cervix and vagina following resectoscope metroplasty. METHODS: The pregnancy outcomes of 21 women who underwent vaginal and uterine septum resection were compared with those of 15 untreated women with similar clinical characteristics. The Fisher exact test and the Mann-Whitney test were used for statistical analysis. RESULTS: Cycle fecundity was better (33.4%+/-28.5% vs 12.2%+/-4.7%; P=0.046), the rate of term delivery significantly increased (P<0.05), and the rate of spontaneous abortion decreased (P<0.05) in the treatment group. CONCLUSION: Resectoscope metroplasty was found to improve the pregnancy outcomes of women having primary infertility or a history of pregnancy loss associated with a complete uterine septum with double cervix and vagina.

Lin K; Zhu X; Xu H; Liang Z; Zhang X

2009-04-01

114

Inverted papilloma of the cervix and vagina: report of 2 cases of a rare lesion associated with human papillomavirus 42.  

UK PubMed Central (United Kingdom)

We report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. Microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting islands, trabeculae, and solid sheets of bland transitional epithelium with an inverted growth pattern. There were small foci of squamous and glandular differentiation in the cervical case. Linear array human papillomavirus genotyping revealed human papillomavirus type 42 in both cases. Inverted papilloma in the lower female genital tract is extremely rare with, as far as we are aware, only 3 previously reported similar cases in the cervix and none in the vagina. Our results suggest that these neoplasms when occurring in the lower female genital tract may be associated with low-risk human papillomavirus, perhaps specifically human papillomavirus 42.

Hennell C; Jamison J; Wells M; McCluggage WG

2012-03-01

115

Inverted papilloma of the cervix and vagina: report of 2 cases of a rare lesion associated with human papillomavirus 42.  

Science.gov (United States)

We report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. Microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting islands, trabeculae, and solid sheets of bland transitional epithelium with an inverted growth pattern. There were small foci of squamous and glandular differentiation in the cervical case. Linear array human papillomavirus genotyping revealed human papillomavirus type 42 in both cases. Inverted papilloma in the lower female genital tract is extremely rare with, as far as we are aware, only 3 previously reported similar cases in the cervix and none in the vagina. Our results suggest that these neoplasms when occurring in the lower female genital tract may be associated with low-risk human papillomavirus, perhaps specifically human papillomavirus 42. PMID:21813160

Hennell, Claire; Jamison, Jackie; Wells, Michael; McCluggage, W Glenn

2011-08-02

116

[HPV-associated alterations of the vulva and vagina. Morphology and molecular pathology].  

Science.gov (United States)

Non-neoplastic HPV-induced alterations of the vulva and vagina are frequent. The traditional three-tier grading system of vulvar intraepithelial neoplasia (VIN) will be replaced by the definition of usual and simplex type of VIN. The usual type is characterized by a strong association to high-risk HPV infections, the occurrence at younger age and multifocality, mostly associated with non-keratinizing squamous cell carcinoma. The differentiated (or simplex) type is rare and shows an association to older age and p53 alterations and is typically diagnosed co-incidentally with keratinizing squamous cell carcinoma. Vaginal intraepithelial neoplasia (VAIN) is still graded into VAIN 1-3 where VAIN 1 and 2 are mostly associated with low-risk HPV infections and a high spontaneous regression rate whereas VAIN 3 represents a high-risk HPV-associated lesion with capable progression into (micro-)invasive carcinoma. The differential diagnosis between a non-neoplastic condylomatous lesion and VIN common type and VAIN may be aided by p16 immunohistochemistry. The HPV-associated invasive vulvo-vaginal cancers are verrucous carcinoma (low-risk HPV) and the high-risk HPV-induced (non-keratinizing) squamous cell carcinoma (NOS), the condylomatous (warty) carcinoma and the very rare vaginal squamo-transitional carcinoma. PMID:22038133

Horn, L-C; Klostermann, K; Hautmann, S; Höhn, A K; Beckmann, M W; Mehlhorn, G

2011-11-01

117

[HPV-associated alterations of the vulva and vagina. Morphology and molecular pathology].  

UK PubMed Central (United Kingdom)

Non-neoplastic HPV-induced alterations of the vulva and vagina are frequent. The traditional three-tier grading system of vulvar intraepithelial neoplasia (VIN) will be replaced by the definition of usual and simplex type of VIN. The usual type is characterized by a strong association to high-risk HPV infections, the occurrence at younger age and multifocality, mostly associated with non-keratinizing squamous cell carcinoma. The differentiated (or simplex) type is rare and shows an association to older age and p53 alterations and is typically diagnosed co-incidentally with keratinizing squamous cell carcinoma. Vaginal intraepithelial neoplasia (VAIN) is still graded into VAIN 1-3 where VAIN 1 and 2 are mostly associated with low-risk HPV infections and a high spontaneous regression rate whereas VAIN 3 represents a high-risk HPV-associated lesion with capable progression into (micro-)invasive carcinoma. The differential diagnosis between a non-neoplastic condylomatous lesion and VIN common type and VAIN may be aided by p16 immunohistochemistry. The HPV-associated invasive vulvo-vaginal cancers are verrucous carcinoma (low-risk HPV) and the high-risk HPV-induced (non-keratinizing) squamous cell carcinoma (NOS), the condylomatous (warty) carcinoma and the very rare vaginal squamo-transitional carcinoma.

Horn LC; Klostermann K; Hautmann S; Höhn AK; Beckmann MW; Mehlhorn G

2011-11-01

118

Phospholipase activity of Candida albicans isolated from vagina and urine samples  

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Full Text Available Introduction and objective: Candida albicans is the most virulent among the Candida species, and can cause several forms of candidiasis in human. Extracellular phospholipases in C. albicans is discussed as one of the virulence factors. The present study, focused on extracellular phospholipase activities in different isolates of C. albicans isolated from vagina and urine samples from Ahvaz, Iran. In addition, phospholipase activities were compared in C. albicans isolated from two different sources. Materials and methods: In the present study, phospholipase activity of 100 isolates of C. albicans with urine and vaginitis origin was demonstrated using Sabouraud's dextrose agar supplemented with egg yolk. Results: The phospholipase activity was detected in all tested isolates with a high level in Pz<0.70. In the present study phospholipase activity with higher Pz values was more common in vaginal isolates (84.7% isolates with Pz value <0.70) compared with 75% in urine isolates. Conclusion: In the present study, 100% clinical isolates of C. albicans from vaginitis and urine samples demonstrated phospholipase activity.

Ali Zarei Mahmoudabadi; Majid Zarrin; Sanaz Miry

2010-01-01

119

Recurrent paediatric pinworm infection of the vagina as a potential reservoir for Enterobius vermicularis.  

Science.gov (United States)

Enterobius vermicularis infection remains one of the most common parasitic infections, particularly prevalent in children. Enterobiasis, although not usually dangerous, may cause significant morbidity. Elimination of the parasite from a family or an institution often poses problems, either because of an incomplete cure or re-infection. While there have been limited reports of ectopic enterobiasis throughout the world, ours is probably one of the rarest reports of recurrent vaginal E. vermicularis infection in the absence of any gastrointestinal symptoms despite complete treatment. A 4-year-old girl presented with recurrent episodes of vulval itching on 3-4 occasions over 2 years. There was no pruritis ani nor urinary/gastrointestinal complaints. The vulva was inflamed with 4-5 living worms, 6-7 mm in length, emerging from the anterior vaginal fornix, but with no vaginal discharge. Direct microscopic examination of vaginal swabs revealed adult worms of Enterobius but no eggs. Repeated stool samples from the patient, parents and a sibling were negative. The patient was treated orally with 100 mg of mebendazole for 3 days followed by two more courses at 3-week intervals over a period of 3 months. Recurrent vaginal enterobiasis despite complete treatment and in the absence of any gastrointestinal involvement suggests that the vagina is a potential reservoir for E. vermicularis, which supports the theory of rare ectopic enterobiasis through the ascending pathway of the female genital tract. PMID:23721910

Kashyap, B; Samantray, J C; Kumar, S; Jhamb, R; Singh, A K; Kaur, I R

2013-05-31

120

Reconstruction of the anus, rectovaginal septum, and distal part of the vagina after postirradiation necrosis. Report of a unique case  

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Successful repair of postirradiation total loss of the anal sphincters, rectovaginal septum, and distal part of the vagina is reported. Gracilis muscle flap was used as a substitute sphincter. Part of the muscle was wrapped-up in a split skin graft. To the authors' knowledge, this is the first report on new application of gracilis muscle and split skin graft in perineal reconstruction.

Nowacki, M.P.; Towpik, E.

1988-08-01

 
 
 
 
121

[Microbiological evaluation of the vagina in women being screened for inflammatory and precancerous conditions of female genitalia  

UK PubMed Central (United Kingdom)

The aim of this work was to study the microbiology of vaginal secretion in 3665 (19 to 72 year old) women investigated in the screening programme for inflammatory and malignant diseases. Microbiological examinations of the vaginal contents were carried out using direct preparations (Miller and Gram methods) and different media for cultures. Normal biocenosis (I and II grade of cleanliness) of the vagina was observed in 40.74% investigated patients. Abnormal biocenosis was classified as early, advanced and chronic state infections. In our study we present data on isolated strains of saprophytic organisms and pathogens including yeasts and Trichomonas vaginalis in early and chronic infections. There were homogeneous and mixed infections. The role of the physiological Lactobacillus species inhibiting development of pathogenic flora is suggestive of beneficial influence on the vaginal environment. Candidiasis of the vagina was identified in 11.35% examined women. High percentage Candida growth was found together with Lactobacillus vaginalis. It is noteworthy that trichomoniasis was less frequent compared to our previous reports. Totally we were able to isolate 2597 strains of bacteria. Bacteria type of abnormal biocenosis was found in 46.82%. The data from this study indicated that microbiological pictures (stained acc. to both Miller and Gram methods) are still of importance for the evaluation of vaginal contents. The second significant factor in microbiology of human vagina is the role of culture. This role of cultures for microbiologic studies of vaginal contents is beyond any doubt.

Kuczy?ska K

1999-04-01

122

[Infected hematoma of Douglas pouch: a specific complication of the surgical excision of deep endometriosis involving the vagina].  

UK PubMed Central (United Kingdom)

OBJECTIVE: Surgical management of deep pelvic endometriosis may be responsible for various complications, such as infected pelvic haematic collection of the Douglas pouch. The aim of this study is to describe this unfavourable outcome and to estimate its frequency in the series of women managed by our team. PATIENTS AND METHODS: Retrospective study enrolling 163 women undergoing surgical removal of deep posterior endometriosis involving the vagina, from January 2008 to September 2011. We indentified women presenting with postoperative fever associated with computed tomographic findings suggesting an abscess of the Douglas pouch. Women characteristics, complication's management and outcomes were analysed in each case. RESULTS: Ten patients presented an inflammatory syndrome associated to hypothetical Douglas pouch abscess, revealed 6 days postoperatively on average. All women reported increasing pelvic pain, fever higher than 38.5°C, increased level of leucocytes and C reactive protein, and liquid collection of the Douglas pouch. Surgical management was carried out in nine women, revealing a pelvic collection of cloudy haematic liquid. Various bacteria were identified in six cases out of nine, suggesting liquid contamination through vagina opening. Postoperative outcome were immediately favourable. DISCUSSION AND CONCLUSION: Inflammatory syndrome associated with infected haematic collection of the Douglas pouch is a postoperative complication of the surgical removal of deep endometriosis involving the posterior vagina. Surgical removal of the haematic collection allows rapid and definitive favourable outcomes.

Sanguin S; Roman H; Vassilieff M; Bridoux V; Da Costa C; Martin C; Marpeau L; Puscasiu L

2013-03-01

123

Avaliação dosimétrica de uma combinação de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porção distal da vagina Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVO: Avaliar uma alternativa de braquiterapia para tumores do colo uterino acometendo a porção distal da vagina, sem aumentar os riscos de toxicidade. MATERIAIS E MÉTODOS: Estudo teórico comparando três diferentes aplicadores de braquiterapia intracavitária de alta taxa de dose: sonda intrauterina e cilindro vaginal (SC); sonda e anel associado ao cilindro vaginal (SA+C) e um aplicador virtual com sonda, anel e cilindro vaginal em um único conjunto (SAC). Foram prescritas doses de 7 Gy no ponto A e 5 Gy na superfície ou a 5 mm de profundidade na mucosa vaginal, mantendo as doses nos pontos de reto, bexiga e sigmoide abaixo dos limites de tolerância. Foram comparados os volumes englobados pelas isodoses de 50% (V50), 100% (V100), 150% (V150) e 200% (V200), respectivamente. RESULTADOS: Tanto SA+C quanto SAC apresentaram melhor distribuição de dose quando comparados ao aplicador SC. A distribuição de dose obtida com SA+C foi semelhante à do aplicador SAC, sendo V150 e V200 cerca de 50% maiores para SA+C, todavia, dentro do cilindro. CONCLUSÃO: A utilização de SA+C em uma única aplicação em dois tempos pode ser uma alternativa de tratamento para pacientes que apresentam tumores de colo uterino com acometimento distal da vagina.OBJECTIVE: To evaluate an alternative brachytherapy technique for uterine cervix cancer involving the distal vagina, without increasing the risk of toxicity. MATERIALS AND METHODS: Theoretical study comparing three different high-dose rate intracavitary brachytherapy applicators: intrauterine tandem and vaginal cylinder (TC); tandem/ring applicator combined with vaginal cylinder (TR+C); and a virtual applicator combining both the tandem/ring and vaginal cylinder in a single device (TRC). Prescribed doses were 7 Gy at point A, and 5 Gy on the surface or at a 5 mm depth of the vaginal mucosa. Doses delivered to the rectum, bladder and sigmoid colon were kept below the tolerance limits. Volumes covered by the isodoses, respectively, 50% (V50), 100% (V100), 150% (V150) and 200% (V200) were compared. RESULTS: Both the combined TR+C and TRC presented a better dose distribution as compared with the TC applicator. The TR+C dose distribution was similar to the TRC dose, with V150 and V200 being about 50% higher for TR+C (within the cylinder). CONCLUSION: Combined TR+C in a two-time single application may represent an alternative therapy technique for patients affected by uterine cervix cancer involving the distal vagina.

Roger Guilherme Rodrigues Guimarães; Heloisa de Andrade Carvalho; Silvia Radwanski Stuart; Rodrigo Augusto Rubo; Rodrigo Migotto Seraide

2009-01-01

124

Avaliação dosimétrica de uma combinação de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porção distal da vagina/ Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVO: Avaliar uma alternativa de braquiterapia para tumores do colo uterino acometendo a porção distal da vagina, sem aumentar os riscos de toxicidade. MATERIAIS E MÉTODOS: Estudo teórico comparando três diferentes aplicadores de braquiterapia intracavitária de alta taxa de dose: sonda intrauterina e cilindro vaginal (SC); sonda e anel associado ao cilindro vaginal (SA+C) e um aplicador virtual com sonda, anel e cilindro vaginal em um único conjunto (SAC). Fora (more) m prescritas doses de 7 Gy no ponto A e 5 Gy na superfície ou a 5 mm de profundidade na mucosa vaginal, mantendo as doses nos pontos de reto, bexiga e sigmoide abaixo dos limites de tolerância. Foram comparados os volumes englobados pelas isodoses de 50% (V50), 100% (V100), 150% (V150) e 200% (V200), respectivamente. RESULTADOS: Tanto SA+C quanto SAC apresentaram melhor distribuição de dose quando comparados ao aplicador SC. A distribuição de dose obtida com SA+C foi semelhante à do aplicador SAC, sendo V150 e V200 cerca de 50% maiores para SA+C, todavia, dentro do cilindro. CONCLUSÃO: A utilização de SA+C em uma única aplicação em dois tempos pode ser uma alternativa de tratamento para pacientes que apresentam tumores de colo uterino com acometimento distal da vagina. Abstract in english OBJECTIVE: To evaluate an alternative brachytherapy technique for uterine cervix cancer involving the distal vagina, without increasing the risk of toxicity. MATERIALS AND METHODS: Theoretical study comparing three different high-dose rate intracavitary brachytherapy applicators: intrauterine tandem and vaginal cylinder (TC); tandem/ring applicator combined with vaginal cylinder (TR+C); and a virtual applicator combining both the tandem/ring and vaginal cylinder in a sing (more) le device (TRC). Prescribed doses were 7 Gy at point A, and 5 Gy on the surface or at a 5 mm depth of the vaginal mucosa. Doses delivered to the rectum, bladder and sigmoid colon were kept below the tolerance limits. Volumes covered by the isodoses, respectively, 50% (V50), 100% (V100), 150% (V150) and 200% (V200) were compared. RESULTS: Both the combined TR+C and TRC presented a better dose distribution as compared with the TC applicator. The TR+C dose distribution was similar to the TRC dose, with V150 and V200 being about 50% higher for TR+C (within the cylinder). CONCLUSION: Combined TR+C in a two-time single application may represent an alternative therapy technique for patients affected by uterine cervix cancer involving the distal vagina.

Guimarães, Roger Guilherme Rodrigues; Carvalho, Heloisa de Andrade; Stuart, Silvia Radwanski; Rubo, Rodrigo Augusto; Seraide, Rodrigo Migotto

2009-08-01

125

Definitive radiation therapy for invasive carcinoma of the vagina. Impact of high-dose rate intracavitary brachytherapy  

International Nuclear Information System (INIS)

[en] This study was designed to evaluate the efficacy of definitive radiation therapy (RT) for invasive carcinoma of the vagina. Twenty-six patients with invasive carcinoma of the vagina who received RT were studied retrospectively. The median age was 68 years. The pathologic subtype of vaginal carcinoma was squamous cell carcinoma in 24 patients, adenosquamous cell carcinoma in one patient, and adenocarcinoma in one patient. The distribution of clinical stage according to the International Federation of Gynecology and Obstetrics staging system was as follows: stage I, seven patients; stage II, 10 patients, stage III, seven patients; and stage IVA, two patients. Twenty patients received external beam radiation therapy (EBRT) combined with high-dose rate intracavitary brachytherapy (HDR-ICBT), and three received EBRT alone. The remaining three patients with stage I disease were given HDR-ICBT alone. The median dose was 50 Gy for EBRT, and 23 Gy for HDR-ICBT. Systemic chemotherapy was administered concurrently with RT to three patients. The median follow-up was 90 months. The initial rate of response to RT was 100%, and complete remission was attained in 21 patients (81%). The 5-year overall survival rate (OS) and the median survival time of the 26 patients were 57% and 97 months, respectively. The 5-year OS for the three patients who received HDR-ICBT alone was 100%. Severe toxicity occurred in three patients-grade 3 rectal hemorrhage in one, grade 3 cystitis in one, and grade 4 cystitis in one. Our results demonstrated that definitive RT with HDR-ICBT is effective for invasive carcinoma of the vagina, with acceptable toxicity. (author)

2013-01-01

126

The effect of copaiba balsam on Walker 256 carcinoma inoculated into the vagina and uterine cervix of female rats Efeito do óleo de copaíba no tumor de Walker 256 inoculado em vagina e colo de útero de ratas fêmeas  

Directory of Open Access Journals (Sweden)

Full Text Available PURPOSE: To verify the copaiba balsam (Copaifera officinalis) effect on Walker 256 carcinoma inoculated into vagina and uterine cervix of rats. METHODS: Eighteen female Wistar rats weighing between 180-250g were used, distributed into 2 groups (GCop, GC). On the 1st day of the experiment, 0.3 ml of Walker 256 carcinoma (2x10(6) concentration) was inoculated in both groups; on the 3rd day of the experiment, it was given 4.8 ml/kg of distilled water to the GC group, and 4.8 ml/kg of copaiba balsam to the GCop group. On the 12th day, euthanasia was performed and the tumor was grafted, being weighted and verified its volume. The data were submitted to statistical analysis with ANOVA test. RESULTS: It was observed that copaiba balsam presented a negative inhibitory potential of 70%. CONCLUSION: The copaiba balsam stimulated the tumor growth.OBJETIVO: Verificar o efeito do óleo de copaíba da espécie Copaifera officinalis no carcinoma de Walker 256 inoculado em vagina e colo de útero de ratas. MÉTODOS: Foram utilizadas 18 ratas da linhagem Wistar, pesando entre 180-250g, distribuídas em dois grupos (CCop, GC). No 1º dia de experimento, em ambos os grupos foi inoculado 0,3ml de tumor de Walker 256 na concentração de 2x10(6); no 3º dia após essa inoculação, foi iniciada a administração de água destilada na dose de 4,8 ml/kg ao GC, e copaíba na dose de 4,8 ml/kg ao GCop. No 12º dia foi realizada a eutanásia das ratas e ressecado o tumor, sendo este pesado e averiguado seu volume. Os dados obtidos foram submetidos à análise estatística pelo método ANOVA. RESULTADOS: Observou-se que o óleo de copaíba apresentou um potencial inibitório negativo de 70%. CONCLUSÃO: O óleo de copaíba estimulou o crescimento tumoral.

Nara Macedo Botelho Brito; Marcus Vinicius Henriques Brito; Rita de Kássia Vidigal Carvalho; Lia Tavares de Moura Brasil Matos; Rodolfo Costa Lobato; Suelen Costa Correa; Rosângela Baía Brito

2010-01-01

127

Adhesion of Lactobacillus iners AB-1 to Human fibronectin: a key mediator for persistence in the vagina?  

UK PubMed Central (United Kingdom)

Lactobacillus iners is prominent in the human vagina and is able to persist despite development of bacterial vaginosis and treatment with antibiotics. A probable factor in its persistent survival is its ability to be retained in the vaginal epithelia. Genome sequencing of the strain showed an organism deplete of many metabolic pathways, yet equipped with fibronectin (Fn)-binding adhesins. The objective of the present study was to assess the ability of L iners AB-1 to bind immobilized Fn. Results showed that the organism superiorly bound the protein compared to other species of Lactobacillus and known binders such as Staphylococcus aureus. Treatment of L iners cells by protease rendered its binding abilities to Fn nonfunctional. The findings indicate a mechanism of vaginal persistence for a Lactobacillus species, with implications for reproductive health.

McMillan A; Macklaim JM; Burton JP; Reid G

2013-07-01

128

Progestagen-concentrating cells in the brain, uterus, vagina and mammary glands of the galago (Galago senegalensis).  

UK PubMed Central (United Kingdom)

Progestagen-concentrating cells were localized in the oestrogen-primed ovariectomized galago by radioautography after injection of [3H]promegestone (R5020). In the brain, radioactivity was concentrated in the nuclei of neurones in the preoptic region and in the mediobasal hypothalamus. Labelled cells were also observed in the anterior pituitary. In the uterus (uterine horns and cervix), the muscle and stromal cells showed greater labelling than did the glandular and luminal epithelia. Labelled cells were present in the different cell layers of the vagina. The majority of glandular epithelial cells of the mammary glands exhibited a high degree of labelling. Pretreatment with an excess of unlabelled promegestone but not with an excess of nonradioactive testosterone reduced the nuclear concentration of radioactivity in these target tissues. These results show that there are no major differences in the distribution of progestagen-concentrating cells in rodents and galago.

Warembourg M

1983-05-01

129

Progestagen-concentrating cells in the brain, uterus, vagina and mammary glands of the galago (Galago senegalensis).  

Science.gov (United States)

Progestagen-concentrating cells were localized in the oestrogen-primed ovariectomized galago by radioautography after injection of [3H]promegestone (R5020). In the brain, radioactivity was concentrated in the nuclei of neurones in the preoptic region and in the mediobasal hypothalamus. Labelled cells were also observed in the anterior pituitary. In the uterus (uterine horns and cervix), the muscle and stromal cells showed greater labelling than did the glandular and luminal epithelia. Labelled cells were present in the different cell layers of the vagina. The majority of glandular epithelial cells of the mammary glands exhibited a high degree of labelling. Pretreatment with an excess of unlabelled promegestone but not with an excess of nonradioactive testosterone reduced the nuclear concentration of radioactivity in these target tissues. These results show that there are no major differences in the distribution of progestagen-concentrating cells in rodents and galago. PMID:6682445

Warembourg, M

1983-05-01

130

Disturbances in the vagina development of the white rat off spring under the effect of X-ray irradiation  

International Nuclear Information System (INIS)

[en] 120 embryos of white rats from 13 to 22 days old irradiated with X-rays at 12-th-14-th days of embryogenesis. The embryos are classified in the series of sagittal, transversal, frontal cross sections and are dyed with conVentional techniques. The formation of paramesonefral tracts is obserVed in all experimental animals. The violations of the vaginal development manifest themselves in the time delay of connection of paramesonefral tracts resorption of medial partition between connected tracts, separation of the sinus vaginal part from the genitourinary sinus, recanalization of vaginal epithelial band. More serious injuries are presented by agenesis of the sinus part of vagina and atresia of the organ in the form of its transverse separation by a partition

1983-01-01

131

Adjuvant and definitive radiation therapy for primary carcinoma of the vagina using brachytherapy and external beam radiation therapy.  

UK PubMed Central (United Kingdom)

PURPOSE: To report the outcomes of patients receiving vaginal brachytherapy and/or external beam radiation therapy (EBRT) for primary vaginal cancer. MATERIAL AND METHODS: Between 1983 and 2009, 63 patients received brachytherapy and/or EBRT for primary tumors of the vagina at a single tertiary center. Patient data was collected via chart review. The Kaplan-Meier method was used to calculate actuarial pelvic local control (LC), disease-free survival (DFS), overall survival (OS), and severe late toxicity rates. Acute and late toxicities were scored according to the Common Terminology Criteria for Adverse Events version 3 (CTCAE v3.0). RESULTS: Median follow up was 44.2 months. Patients with early stage disease (stages I and II) had significantly improved 5-year OS when compared to patients with locally advanced disease (stages III and IVA) (73.3 vs. 34.4%, p = 0.032). Patients with greater than 1/3 vaginal involvement had significantly worse prognosis than patients with tumors involving 1/3 or less of the vagina, with the later having superior DFS (84.0 vs. 52.4%, p = 0.007) and LC (86.9 vs. 60.4%, p = 0.018) at 5-years. Age, histology, and brachytherapy technique did not impact treatment outcomes. The 5-year actuarial grade 3 or higher toxicity rate was 23.1% (95% CI: 10.6-35.6%). Concurrent chemotherapy had no impact on outcomes or toxicity in this analysis. CONCLUSIONS: Success of treatment for vaginal cancer depends primarily on disease stage, but other contributing factors such as extent of vaginal involvement and tumor location significantly impact outcomes. Treatment of vaginal cancer with primary radiotherapy yields acceptable results with reasonable toxicity rates. Management of this rare malignancy requires a multidisciplinary approach to appropriately optimize therapy.

Platta CS; Anderson B; Geye H; Das R; Straub M; Bradley K

2013-06-01

132

Adjuvant and definitive radiation therapy for primary carcinoma of the vagina using brachytherapy and external beam radiation therapy  

Science.gov (United States)

Purpose To report the outcomes of patients receiving vaginal brachytherapy and/or external beam radiation therapy (EBRT) for primary vaginal cancer. Material and methods Between 1983 and 2009, 63 patients received brachytherapy and/or EBRT for primary tumors of the vagina at a single tertiary center. Patient data was collected via chart review. The Kaplan-Meier method was used to calculate actuarial pelvic local control (LC), disease-free survival (DFS), overall survival (OS), and severe late toxicity rates. Acute and late toxicities were scored according to the Common Terminology Criteria for Adverse Events version 3 (CTCAE v3.0). Results Median follow up was 44.2 months. Patients with early stage disease (stages I and II) had significantly improved 5-year OS when compared to patients with locally advanced disease (stages III and IVA) (73.3 vs. 34.4%, p = 0.032). Patients with greater than 1/3 vaginal involvement had significantly worse prognosis than patients with tumors involving 1/3 or less of the vagina, with the later having superior DFS (84.0 vs. 52.4%, p = 0.007) and LC (86.9 vs. 60.4%, p = 0.018) at 5-years. Age, histology, and brachytherapy technique did not impact treatment outcomes. The 5-year actuarial grade 3 or higher toxicity rate was 23.1% (95% CI: 10.6-35.6%). Concurrent chemotherapy had no impact on outcomes or toxicity in this analysis. Conclusions Success of treatment for vaginal cancer depends primarily on disease stage, but other contributing factors such as extent of vaginal involvement and tumor location significantly impact outcomes. Treatment of vaginal cancer with primary radiotherapy yields acceptable results with reasonable toxicity rates. Management of this rare malignancy requires a multidisciplinary approach to appropriately optimize therapy.

Anderson, Bethany; Geye, Heather; Das, Rupak; Straub, Margaret; Bradley, Kristin

2013-01-01

133

Dosimetric evaluation of a newly designed low dose rate brachytherapy applicator for treatment of cervical cancer with extension into the lower vagina.  

UK PubMed Central (United Kingdom)

Currently, patients having cervical cancer with extension into the lower vagina are being treated with a combination of the Fletcher-Suit applicator, which treats the cervix, and a vaginal cylinder, which treats the lower vagina. With this method, patients receive two separate implants-a procedure that creates greater uncertainty in the dose distribution and unnecessary patient inconvenience. To reduce the uncertainty of the dose delivery and to eliminate patient inconvenience, a new applicator was designed and fabricated at the University of Kentucky for treatment of cervical cancer extending into the lower vagina. In addition, the geometric design of the new device allows for treatment of cervical cancer without extension into the lower vagina and simultaneously provides advantages relative to the commonly used Fletcher-Suit applicator. The dosimetric characteristics of this new applicator (hereafter called Meigooni applicator) were determined using experimental procedures. The measurements were performed using tissue-equivalent phantom material (Solid Water: Gammex RMI, Middleton, WI) that was machined to accommodate the applicator and LiF thermoluminescent dosimetry chips. The applicator was loaded with 137Cs brachytherapy sources in a standard loading scheme. A similar experimental procedure was performed using the currently available Fletcher-Suit mini-ovoid applicator. The results obtained with each applicator were compared with the values calculated by two commercially available treatment planning systems. The experiments showed that the Meigooni applicator allows for safe single treatment of cervical cancer that has extended into the lower vagina, eliminating the need for two separate treatment techniques. Moreover, the Meigooni applicator can function as an alternative to the Fletcher-Suit applicator for the treatment of patients with cervical cancer.

Baker C; Dini SA; Kudrimoti M; Awan SB; Meigooni AS

2007-01-01

134

Dosimetric evaluation of a newly designed low dose rate brachytherapy applicator for treatment of cervical cancer with extension into the lower vagina.  

Science.gov (United States)

Currently, patients having cervical cancer with extension into the lower vagina are being treated with a combination of the Fletcher-Suit applicator, which treats the cervix, and a vaginal cylinder, which treats the lower vagina. With this method, patients receive two separate implants-a procedure that creates greater uncertainty in the dose distribution and unnecessary patient inconvenience. To reduce the uncertainty of the dose delivery and to eliminate patient inconvenience, a new applicator was designed and fabricated at the University of Kentucky for treatment of cervical cancer extending into the lower vagina. In addition, the geometric design of the new device allows for treatment of cervical cancer without extension into the lower vagina and simultaneously provides advantages relative to the commonly used Fletcher-Suit applicator. The dosimetric characteristics of this new applicator (hereafter called Meigooni applicator) were determined using experimental procedures. The measurements were performed using tissue-equivalent phantom material (Solid Water: Gammex RMI, Middleton, WI) that was machined to accommodate the applicator and LiF thermoluminescent dosimetry chips. The applicator was loaded with 137Cs brachytherapy sources in a standard loading scheme. A similar experimental procedure was performed using the currently available Fletcher-Suit mini-ovoid applicator. The results obtained with each applicator were compared with the values calculated by two commercially available treatment planning systems. The experiments showed that the Meigooni applicator allows for safe single treatment of cervical cancer that has extended into the lower vagina, eliminating the need for two separate treatment techniques. Moreover, the Meigooni applicator can function as an alternative to the Fletcher-Suit applicator for the treatment of patients with cervical cancer. PMID:17592462

Baker, Curtis; Dini, Sharifeh A; Kudrimoti, Mahesh; Awan, Shahid B; Meigooni, Ali S

2007-04-19

135

Caracterização de leveduras isoladas da vagina e sua associação com candidíase vulvovaginal em duas cidades do sul do Brasil Characterization of yeasts isolated from the vagina and their association with vulvovaginal candidíasis in two cities of the South of Brazil  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVOS: avaliar a distribuição de espécies de leveduras isoladas da vagina em duas localidades do sul do Brasil e comparar o perfil de suscetibilidade in vitro destas leveduras a antifúngicos usados na prática clínica. MÉTODOS: todas as mulheres atendidas entre janeiro e junho de 2004 para exames rotineiros de amostras vaginais, independente de serem sintomáticas ou não, foram incluídas neste estudo. Foram excluídas as que apresentavam imunodeficiências como AIDS ou outras infecções genitais. Amostras de conteúdo vaginal dessas mulheres (Jaraguá do Sul - SC (n=130) e Maringá - PR (n=97)) foram cultivadas. As leveduras isoladas foram identificadas e submetidas ao teste de suscetibilidade aos antifúngicos fluconazol, nistatina e anfotericina B. RESULTADOS: a freqüência de cultura positiva para levedura foi semelhante nas duas localidades, aproximadamente 24%. Candida albicans foi a espécie prevalente, mas sua freqüência diferiu: em SC correspondeu a 77,4% das leveduras e foi a mais freqüente tanto nas mulheres sintomáticas quanto nas assintomáticas. Já no PR foi 50,0%, com predomínio mais evidente nos casos sintomáticos. Observamos altos índices de suscetibilidade ao fluconazol e anfotericina B, porém 51,1% das leveduras apresentaram suscetibilidade dependente da dose (S-DD) para nistatina. C. albicans mostrou maior tendência de resistência à nistatina (52,8% de S-DD) do que as espécies não-albicans (44,4%). CONCLUSÕES: nossos dados mostram diferenças regionais quanto à espécie de levedura em amostras vaginais. Sugerem que a determinação da espécie pode ter implicação clínica, considerando as diferenças quanto à suscetibilidade, principalmente à nistatina, e que poderiam ter importância no manejo da candidíase vulvovaginal.PURPOSE: to evaluate the distribution of yeast species isolated from the vagina in two cities of the South of Brazil and compare the in vitro susceptibility profile of these yeasts against some antifungals, which are used in clinical routine. METHODS: all women attended from January to June 2004 for vaginal routine examinations, independent of being symptomatic or not were included in the study. Only those who presented immunodeficiency like AIDS or any other genital infection were excluded. Samples of vaginal discharge from the women (Jaraguá do Sul - SC (n=130) and Maringá - PR (n=97)) were cultivated. The yeasts were identified and submitted to the susceptibility test against the antifungals fluconazole, nystatin and amphotericin B. RESULTS: the frequency of positive cultures for yeasts was the same in both cities; C. albicans was the most prevalent species (about 24%), but its frequency was different: in SC it corresponded to 77.4% of the yeasts both in symptomatic and asymptomatic women and in PR it was 50.0% with predominance in symptomatic women. We observed high rates of susceptibility to fluconazole and amphotericin B, but 51.1% of the yeasts presented dose-dependent susceptibility (DDS) to nystatin. C. albicans showed a higher tendency to be nystatin resistant (52.8% DDS) than non-albicans species (44.4%). CONCLUSIONS: our data showed geographic differences among the species of yeasts isolated from the vagina and suggest that this fact has clinical relevance considering the differences in susceptibility, especially regarding nystatin, which could be important for the management of vulvovaginal candidiasis.

Magda Helena S. H. Ferrazza; Márcia L. Ferrarezi Maluf; Marcia Edilaine Lopes Consolaro; Cristiane Suemi Shinobu; Terezinha Inez Estivalet Svidzinski; Márcia Regina Batista

2005-01-01

136

Caracterização de leveduras isoladas da vagina e sua associação com candidíase vulvovaginal em duas cidades do sul do Brasil/ Characterization of yeasts isolated from the vagina and their association with vulvovaginal candidíasis in two cities of the South of Brazil  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVOS: avaliar a distribuição de espécies de leveduras isoladas da vagina em duas localidades do sul do Brasil e comparar o perfil de suscetibilidade in vitro destas leveduras a antifúngicos usados na prática clínica. MÉTODOS: todas as mulheres atendidas entre janeiro e junho de 2004 para exames rotineiros de amostras vaginais, independente de serem sintomáticas ou não, foram incluídas neste estudo. Foram excluídas as que apresentavam imunodeficiências com (more) o AIDS ou outras infecções genitais. Amostras de conteúdo vaginal dessas mulheres (Jaraguá do Sul - SC (n=130) e Maringá - PR (n=97)) foram cultivadas. As leveduras isoladas foram identificadas e submetidas ao teste de suscetibilidade aos antifúngicos fluconazol, nistatina e anfotericina B. RESULTADOS: a freqüência de cultura positiva para levedura foi semelhante nas duas localidades, aproximadamente 24%. Candida albicans foi a espécie prevalente, mas sua freqüência diferiu: em SC correspondeu a 77,4% das leveduras e foi a mais freqüente tanto nas mulheres sintomáticas quanto nas assintomáticas. Já no PR foi 50,0%, com predomínio mais evidente nos casos sintomáticos. Observamos altos índices de suscetibilidade ao fluconazol e anfotericina B, porém 51,1% das leveduras apresentaram suscetibilidade dependente da dose (S-DD) para nistatina. C. albicans mostrou maior tendência de resistência à nistatina (52,8% de S-DD) do que as espécies não-albicans (44,4%). CONCLUSÕES: nossos dados mostram diferenças regionais quanto à espécie de levedura em amostras vaginais. Sugerem que a determinação da espécie pode ter implicação clínica, considerando as diferenças quanto à suscetibilidade, principalmente à nistatina, e que poderiam ter importância no manejo da candidíase vulvovaginal. Abstract in english PURPOSE: to evaluate the distribution of yeast species isolated from the vagina in two cities of the South of Brazil and compare the in vitro susceptibility profile of these yeasts against some antifungals, which are used in clinical routine. METHODS: all women attended from January to June 2004 for vaginal routine examinations, independent of being symptomatic or not were included in the study. Only those who presented immunodeficiency like AIDS or any other genital infe (more) ction were excluded. Samples of vaginal discharge from the women (Jaraguá do Sul - SC (n=130) and Maringá - PR (n=97)) were cultivated. The yeasts were identified and submitted to the susceptibility test against the antifungals fluconazole, nystatin and amphotericin B. RESULTS: the frequency of positive cultures for yeasts was the same in both cities; C. albicans was the most prevalent species (about 24%), but its frequency was different: in SC it corresponded to 77.4% of the yeasts both in symptomatic and asymptomatic women and in PR it was 50.0% with predominance in symptomatic women. We observed high rates of susceptibility to fluconazole and amphotericin B, but 51.1% of the yeasts presented dose-dependent susceptibility (DDS) to nystatin. C. albicans showed a higher tendency to be nystatin resistant (52.8% DDS) than non-albicans species (44.4%). CONCLUSIONS: our data showed geographic differences among the species of yeasts isolated from the vagina and suggest that this fact has clinical relevance considering the differences in susceptibility, especially regarding nystatin, which could be important for the management of vulvovaginal candidiasis.

Ferrazza, Magda Helena S. H.; Maluf, Márcia L. Ferrarezi; Consolaro, Marcia Edilaine Lopes; Shinobu, Cristiane Suemi; Svidzinski, Terezinha Inez Estivalet; Batista, Márcia Regina

2005-02-01

137

In silico vs in vitro analysis of primer specificity for the detection of Gardnerella vaginalis, Atopobium vaginae and Lactobacillus spp.  

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Full Text Available Abstract Background Bacterial vaginosis (BV) is a common pathology of women in reproductive age that can lead to serious health complications, and is associated with shifts in the normal microflora from predominance of Lactobacillus spp. to a proliferation of other anaerobes such as G. vaginalis and A vaginae, which can be detected by PCR. The optimal PCR pathogen detection assay relies mainly on the specificity and sensitivity of the primers used. Findings Here we demonstrate that in silico analytical testing of primer specificity is not a synonym to in vitro analytical specificity by testing a range of published and newly designed primers with both techniques for the detection of BV-associated microorganisms. Conclusions By testing primer in vitro specificity with a sufficient range of bacterial strains, we were able to design primers with higher specificity and sensitivity. Also by comparing the results obtained for the newly designed primers with other previously published primers, we confirmed that in silico analysis is not sufficient to predict in vitro specificity. As such care must be taken when choosing the primers for a detection assay.

Henriques Ana; Cereija Tatiana; Machado António; Cerca Nuno

2012-01-01

138

In silico vs in vitro analysis of primer specificity for the detection of Gardnerella vaginalis, Atopobium vaginae and Lactobacillus spp.  

UK PubMed Central (United Kingdom)

BACKGROUND: Bacterial vaginosis (BV) is a common pathology of women in reproductive age that can lead to serious health complications, and is associated with shifts in the normal microflora from predominance of Lactobacillus spp. to a proliferation of other anaerobes such as G. vaginalis and A vaginae, which can be detected by PCR. The optimal PCR pathogen detection assay relies mainly on the specificity and sensitivity of the primers used. FINDINGS: Here we demonstrate that in silico analytical testing of primer specificity is not a synonym to in vitro analytical specificity by testing a range of published and newly designed primers with both techniques for the detection of BV-associated microorganisms. CONCLUSIONS: By testing primer in vitro specificity with a sufficient range of bacterial strains, we were able to design primers with higher specificity and sensitivity. Also by comparing the results obtained for the newly designed primers with other previously published primers, we confirmed that in silico analysis is not sufficient to predict in vitro specificity. As such care must be taken when choosing the primers for a detection assay.

Henriques A; Cereija T; Machado A; Cerca N

2012-01-01

139

The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina) – phenotypic manifestations and genetic approaches  

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Full Text Available Abstract The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome affects at least 1 out of 4500 women and has for a long time been considered as a sporadic anomaly. Congenital absence of upper vagina and uterus is the prime feature of the disease which, in addition, is often found associated with unilateral renal agenesis or adysplasia as well as skeletal malformations (MURCS association). The phenotypic manifestations of MRKH overlap various other syndromes or associations and thus require accurate delineation. Since MRKH manifests itself in males, the term GRES syndrome (Genital, Renal, Ear, Skeletal) might be more appropriate when applied to both sexes. The MRKH syndrome, when described in familial aggregates, seems to be transmitted as an autosomal dominant trait with an incomplete degree of penetrance and variable expressivity. This suggests the involvement of either mutations in a major developmental gene or a limited chromosomal deletion. Until recently progress in understanding the genetics of MRKH syndrome has been slow, however, now HOX genes have been shown to play key roles in body patterning and organogenesis, and in particular during genital tract development. Expression and/or function defects of one or several HOX genes may account for this syndrome.

Guerrier Daniel; Mouchel Thomas; Pasquier Laurent; Pellerin Isabelle

2006-01-01

140

Vaginal rugation rejuvenation (restoration): a new surgical technique for an acquired sensation of wide/smooth vagina.  

UK PubMed Central (United Kingdom)

BACKGROUND: No paper on vaginal columnar rugation rejuvenation has been published so far. OBJECTIVES: To evaluate a new surgical technique of vaginal rugae restoration for the management of an acquired sensation of wide/smooth vagina (ASWSV). METHODS: A prospective observational study was conducted. Ten women with ASWSV (group I) were compared to 10 healthy women (control group II). The vaginal rugation rejuvenation (VRR) technique was developed and appraised. The primary outcome measure was to assess VRR applicability. A secondary outcome measure was to evaluate the surgical resolution of symptoms and signs associated with ASWSV and the impact of VRR on female sexual function. RESULTS: In group I, VRR was executed without complications and the surgical resolution of symptoms and signs associated with ASWSV was observed in all subjects. Improved feelings of penile strokes during coitus were also reported by all subjects of study group I. CONCLUSIONS: VRR (restoration) was accomplished without increasing the risks of complications. Surgical resolution of symptoms and signs was observed and sexual function improved by 18.75% following VRR in group I. This nonrandomized study precluded us from drawing the conclusion that VRR is a safe and effective operation.

Ostrzenski A

2012-01-01

 
 
 
 
141

Study on antiblastomogenic action of epidermal chalones. II. Effect of epidermal chalones on carcinogenesis in the vagina.  

UK PubMed Central (United Kingdom)

The effect of epidermal or liver G1 and G2 chalone-containing extracts (CCE), prepared from rat skin and liver, upon DMBA-induced carcinogenesis in the vagina of BALB/c mice was studied. One per cent solutions of CCE in PBS were administered intravaginally on polyurethane sponges twice a week during the course of intravaginal applications of DMBA or after its completion up to the death of mice. When administered during te course of DMBA treatment, skin CCE prolonged the latency of cervicovaginal tumours in comparison with liver CCE (48.0 +/- 0.37 and 44.8 +/- 0.54 days, respectively; p less than 0.05). When administered after the course of DMBA application, skin CCE prolonged the lifespan of mice bearing cervicovaginal squamous cell carcinomas in comparison with liver CCE (192 +/- 12.3 and 161 +/- 9.0 days, respectively; p less than 0.05). Skin CCE did not possess any general toxic effect on mice and they were bearing CCE applications for a rather a long period without visible side effects.

Okulov VB; Anisimov VN; Chepik OF

1981-01-01

142

Study on antiblastomogenic action of epidermal chalones. II. Effect of epidermal chalones on carcinogenesis in the vagina.  

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The effect of epidermal or liver G1 and G2 chalone-containing extracts (CCE), prepared from rat skin and liver, upon DMBA-induced carcinogenesis in the vagina of BALB/c mice was studied. One per cent solutions of CCE in PBS were administered intravaginally on polyurethane sponges twice a week during the course of intravaginal applications of DMBA or after its completion up to the death of mice. When administered during te course of DMBA treatment, skin CCE prolonged the latency of cervicovaginal tumours in comparison with liver CCE (48.0 +/- 0.37 and 44.8 +/- 0.54 days, respectively; p less than 0.05). When administered after the course of DMBA application, skin CCE prolonged the lifespan of mice bearing cervicovaginal squamous cell carcinomas in comparison with liver CCE (192 +/- 12.3 and 161 +/- 9.0 days, respectively; p less than 0.05). Skin CCE did not possess any general toxic effect on mice and they were bearing CCE applications for a rather a long period without visible side effects. PMID:6459949

Okulov, V B; Anisimov, V N; Chepik, O F

1981-01-01

143

Effect of semen collection method (artificial vagina vs. electroejaculation), extender and centrifugation on post-thaw sperm quality of Blanca-Celtiberica buck ejaculates.  

UK PubMed Central (United Kingdom)

The aim of this study was to evaluate the effect of semen collection method (artificial vagina compared to electroejaculation), season in which the semen was collected (breeding season compared to non-breeding season), freezing extender (Biladyl(®), Andromed(®) and skim milk based extender) and pre-treatment procedure (washing compared to non-washing) on post-thaw semen quality in buck. Ejaculates from seven bucks of the Blanca-Celtibérica breed were collected by artificial vagina and electroejaculation during the breeding (July to December) and non-breeding season (January to June). Samples were split in two aliquots and one of them was washed. Three freezing extenders were evaluated on washing and non-washing sperm samples. Ejaculates collected by artificial vagina had a greater sperm quality after thawing, with greater values (P?0.05) for SM (sperm motility), NAR (acrosome intact), YO-PRO-1-/PI- (intact spermatozoa), and Mitotracker+/YO-PRO-1- (spermatozoa with active mitochondria) and lower % DFI (DNA fragmentation index). Thawed sperm samples which were collected during the breeding season had greater values (P?0.05) for NAR, intact spermatozoa and spermatozoa with active mitochondria, than those semen samples obtained during the non-breeding season. Semen freezing with Biladyl(®) and Andromed(®) resulted in a greater sperm quality (P?0.05) after thawing in relation to milk-based extender. Washing procedure had no effect on sperm parameters assessed at thawing. Results from the present study suggest that the success of semen cryopreservation in Blanca-Celtibérica goat depends on semen collection method and season, as well as on the extender used. Thus, the post-thaw sperm quality will be greater (P?0.05) when samples are collected by artificial vagina during the breeding season and when Biladyl(®) or Andromed(®) are used as freezing extenders.

Jiménez-Rabadán P; Ramón M; García-Álvarez O; Maroto-Morales A; del Olmo E; Pérez-Guzmán MD; Bisbal A; Fernández-Santos MR; Garde JJ; Soler AJ

2012-05-01

144

Effect of semen collection method (artificial vagina vs. electroejaculation), extender and centrifugation on post-thaw sperm quality of Blanca-Celtibérica buck ejaculates.  

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The aim of this study was to evaluate the effect of semen collection method (artificial vagina compared to electroejaculation), season in which the semen was collected (breeding season compared to non-breeding season), freezing extender (Biladyl(®), Andromed(®) and skim milk based extender) and pre-treatment procedure (washing compared to non-washing) on post-thaw semen quality in buck. Ejaculates from seven bucks of the Blanca-Celtibérica breed were collected by artificial vagina and electroejaculation during the breeding (July to December) and non-breeding season (January to June). Samples were split in two aliquots and one of them was washed. Three freezing extenders were evaluated on washing and non-washing sperm samples. Ejaculates collected by artificial vagina had a greater sperm quality after thawing, with greater values (P?0.05) for SM (sperm motility), NAR (acrosome intact), YO-PRO-1-/PI- (intact spermatozoa), and Mitotracker+/YO-PRO-1- (spermatozoa with active mitochondria) and lower % DFI (DNA fragmentation index). Thawed sperm samples which were collected during the breeding season had greater values (P?0.05) for NAR, intact spermatozoa and spermatozoa with active mitochondria, than those semen samples obtained during the non-breeding season. Semen freezing with Biladyl(®) and Andromed(®) resulted in a greater sperm quality (P?0.05) after thawing in relation to milk-based extender. Washing procedure had no effect on sperm parameters assessed at thawing. Results from the present study suggest that the success of semen cryopreservation in Blanca-Celtibérica goat depends on semen collection method and season, as well as on the extender used. Thus, the post-thaw sperm quality will be greater (P?0.05) when samples are collected by artificial vagina during the breeding season and when Biladyl(®) or Andromed(®) are used as freezing extenders. PMID:22572556

Jiménez-Rabadán, P; Ramón, M; García-Álvarez, O; Maroto-Morales, A; del Olmo, E; Pérez-Guzmán, M D; Bisbal, A; Fernández-Santos, M R; Garde, J J; Soler, A J

2012-04-19

145

Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners  

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Background Most studies of the vaginal microflora have been based on culture or on qualitative molecular techniques. Here we applied existing real-time PCR formats for Lactobacillus crispatus, L. gasseri and Gardnerella vaginalis and developed new formats for Atopobium vaginae, L. iners and L. jensenii to obtain a quantitative non culture-based determination of these species in 71 vaginal samples from 32 pregnant and 28 non-pregnant women aged between 18 and 45 years. Results The 71 vaginal microflora samples of these women were categorized, using the Ison and Hay criteria, as refined by Verhelst et al. (2005), as follows: grade Ia: 8 samples, grade Iab: 10, grade Ib: 13, grade I-like: 10, grade II: 11, grade III: 12 and grade IV: 7. L. crispatus was found in all but 5 samples and was the most frequent Lactobacillus species detected. A significantly lower concentration of L. crispatus was found in grades II (p 0.397, p = 0.001) and between L. gasseri and A. vaginae (r = -0.408, p < 0.0001). Conclusion In our study we found a clear negative association between L. iners and L. gasseri and between A. vaginae and L. gasseri. Our results do not provide support for the generally held proposition that grade II is an intermediate stage between grades I and III, because L. gasseri, abundant in grade II is not predominant in grade III, whereas L. iners, abundant in grade III is present only in low numbers in grade II samples.

De Backer, Ellen; Verhelst, Rita; Verstraelen, Hans; Alqumber, Mohammed A; Burton, Jeremy P; Tagg, John R; Temmerman, Marleen; Vaneechoutte, Mario

2007-01-01

146

Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners  

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Full Text Available Abstract Background Most studies of the vaginal microflora have been based on culture or on qualitative molecular techniques. Here we applied existing real-time PCR formats for Lactobacillus crispatus, L. gasseri and Gardnerella vaginalis and developed new formats for Atopobium vaginae, L. iners and L. jensenii to obtain a quantitative non culture-based determination of these species in 71 vaginal samples from 32 pregnant and 28 non-pregnant women aged between 18 and 45 years. Results The 71 vaginal microflora samples of these women were categorized, using the Ison and Hay criteria, as refined by Verhelst et al. (2005), as follows: grade Ia: 8 samples, grade Iab: 10, grade Ib: 13, grade I-like: 10, grade II: 11, grade III: 12 and grade IV: 7. L. crispatus was found in all but 5 samples and was the most frequent Lactobacillus species detected. A significantly lower concentration of L. crispatus was found in grades II (p L. jensenii was found in all grades but showed higher concentration in grade Iab than in grade Ia (p = 0.024). A. vaginae and G. vaginalis were present in high concentrations in grade III, with log10 median concentrations (log10 MC), respectively of 9.0 and 9.2 cells/ml. Twenty (38.5%) of the 52 G. vaginalis positive samples were also positive for A. vaginae. In grade II we found almost no L. iners (log10 MC: 0/ml) but a high concentration of L. gasseri (log10 MC: 8.7/ml). By contrast, in grade III we found a high concentration of L. iners (log10 MC: 8.3/ml) and a low concentration of L. gasseri (log10 MC: 0/ml). These results show a negative association between L. gasseri and L. iners (r = -0.397, p = 0.001) and between L. gasseri and A. vaginae (r = -0.408, p Conclusion In our study we found a clear negative association between L. iners and L. gasseri and between A. vaginae and L. gasseri. Our results do not provide support for the generally held proposition that grade II is an intermediate stage between grades I and III, because L. gasseri, abundant in grade II is not predominant in grade III, whereas L. iners, abundant in grade III is present only in low numbers in grade II samples.

De Backer Ellen; Verhelst Rita; Verstraelen Hans; Alqumber Mohammed A; Burton Jeremy P; Tagg John R; Temmerman Marleen; Vaneechoutte Mario

2007-01-01

147

Characterisation of the bacterial microbiota of the vagina of dairy cows and isolation of pediocin-producing Pediococcus acidilactici  

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Full Text Available Abstract Background Uterine infections in dairy cows lower profitability of dairy operations. Infections of the reproductive tract are related to the overgrowth of pathogenic bacteria during the first three weeks after parturition. However, alterations in the vaginal microbiota composition in the first weeks after parturition remain poorly documented. Results In this study, bacteria isolated from the vagina of healthy pregnant, and infected postpartum cows were characterised by random amplification of polymorphic DNA (RAPD) analysis and partial 16S ribosomal RNA (rDNA) gene sequencing. Populations of bacilli and lactic acid bacteria of the genera Enterococcus, Lactobacillus, and Pediococcus were present in both healthy and infected cows. Infected cows had a significant increase in the vaginal enteric bacteria population which consisted mainly of Escherichia coli. Three E. coli isolates harboured the gene coding for Shiga-like-toxin (SLT) I or II. Several isolates of the Pediococcus acidilactici were found to produce the bacteriocin pediocin AcH/PA-1. Quantitative PCR analyses of vaginal mucus samples collected from ten metritic cows before and after parturition confirmed the presence of the Lactobacillus group (Lactobacillus spp., Pediococcus spp., Leuconostoc spp., and Weissella spp.); Enterobacteriaceae, E. coli, and bacilli. The presence of the pediocin AcH/PA-1 structural gene and SLT genes were also confirmed with qPCR. Conclusions In conclusion, overgrowth of pathogenic bacteria, particularly E. coli, after parturition likely contributes to the development of metritis. Our microbiota analysis extends the information related to the composition of commensal bacteria in the bovine female reproductive tract and may facilitate the development of novel intervention strategies for prevention of uterine infections in dairy cows.

Wang Yvonne; Ametaj Burim N; Ambrose Divakar J; Gänzle Michael G

2013-01-01

148

Characterisation of the bacterial microbiota of the vagina of dairy cows and isolation of pediocin-producing Pediococcus acidilactici.  

UK PubMed Central (United Kingdom)

BACKGROUND: Uterine infections in dairy cows lower profitability of dairy operations. Infections of the reproductive tract are related to the overgrowth of pathogenic bacteria during the first three weeks after parturition. However, alterations in the vaginal microbiota composition in the first weeks after parturition remain poorly documented. RESULTS: In this study, bacteria isolated from the vagina of healthy pregnant, and infected postpartum cows were characterised by random amplification of polymorphic DNA (RAPD) analysis and partial 16S ribosomal RNA (rDNA) gene sequencing. Populations of bacilli and lactic acid bacteria of the genera Enterococcus, Lactobacillus, and Pediococcus were present in both healthy and infected cows. Infected cows had a significant increase in the vaginal enteric bacteria population which consisted mainly of Escherichia coli. Three E. coli isolates harboured the gene coding for Shiga-like-toxin (SLT) I or II. Several isolates of the Pediococcus acidilactici were found to produce the bacteriocin pediocin AcH/PA-1. Quantitative PCR analyses of vaginal mucus samples collected from ten metritic cows before and after parturition confirmed the presence of the Lactobacillus group (Lactobacillus spp., Pediococcus spp., Leuconostoc spp., and Weissella spp.); Enterobacteriaceae, E. coli, and bacilli. The presence of the pediocin AcH/PA-1 structural gene and SLT genes were also confirmed with qPCR. CONCLUSIONS: In conclusion, overgrowth of pathogenic bacteria, particularly E. coli, after parturition likely contributes to the development of metritis. Our microbiota analysis extends the information related to the composition of commensal bacteria in the bovine female reproductive tract and may facilitate the development of novel intervention strategies for prevention of uterine infections in dairy cows.

Wang Y; Ametaj BN; Ambrose DJ; Gänzle MG

2013-01-01

149

Increased diversity of fungal flora in the vagina of patients with recurrent vaginal candidiasis and allergic rhinitis.  

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Recurrent vaginal candidiasis (RVC) is considered to be a hypersensitivity disorder that is associated with allergic rhinitis (AR) in immune deficiencies; however, whether or not the composition of the vaginal fungal flora in patients with AR and RVC is altered and if such alterations in patients with AR are associated with the development of RVC remain unclear. In the present study, a cultivation-independent method with the 18S rRNA gene clone library was used to analyze the diversity and composition of the vaginal fungal flora in patients with AR and RVC and to explore the association. Three fungal phyla (Ascomycotae, 22 out of 28; Basidiomycetes, 5 out of 28; and Oomycetes, 1 out of 28) were identified from groups of healthy volunteers, patients with AR, patients with RVC, and patients with RVC complicated by AR, including 28 phylotypes of fungal flora (10, 15, 17, and 21 phylotypes for each group, respectively). The predominant genera of fungi identified in the vagina included Candida, uncultured fungi, and Dothideomycetes. An increased proportion of Candida albicans accompanied with decreased proportions of Saccharomyces cerevisiae and uncultured fungi was observed in patients with AR or RVC (P?

Guo, Renyong; Zheng, Nengneng; Lu, Haifeng; Yin, Hongfang; Yao, Jinmei; Chen, Yu

2012-07-06

150

Increased diversity of fungal flora in the vagina of patients with recurrent vaginal candidiasis and allergic rhinitis.  

UK PubMed Central (United Kingdom)

Recurrent vaginal candidiasis (RVC) is considered to be a hypersensitivity disorder that is associated with allergic rhinitis (AR) in immune deficiencies; however, whether or not the composition of the vaginal fungal flora in patients with AR and RVC is altered and if such alterations in patients with AR are associated with the development of RVC remain unclear. In the present study, a cultivation-independent method with the 18S rRNA gene clone library was used to analyze the diversity and composition of the vaginal fungal flora in patients with AR and RVC and to explore the association. Three fungal phyla (Ascomycotae, 22 out of 28; Basidiomycetes, 5 out of 28; and Oomycetes, 1 out of 28) were identified from groups of healthy volunteers, patients with AR, patients with RVC, and patients with RVC complicated by AR, including 28 phylotypes of fungal flora (10, 15, 17, and 21 phylotypes for each group, respectively). The predominant genera of fungi identified in the vagina included Candida, uncultured fungi, and Dothideomycetes. An increased proportion of Candida albicans accompanied with decreased proportions of Saccharomyces cerevisiae and uncultured fungi was observed in patients with AR or RVC (P?

Guo R; Zheng N; Lu H; Yin H; Yao J; Chen Y

2012-11-01

151

HOXA10 and HOXA13 sequence variations in human female genital malformations including congenital absence of the uterus and vagina.  

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Congenital genital malformations occurring in the female population are estimated to be 5 per 1000 and associate with infertility, abortion, stillbirth, preterm delivery and other organ abnormalities. Complete aplasia of the uterus, cervix and upper vagina (Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome) has an incidence of 1 per 4000 female live births. The molecular etiology of congenital genital malformations including MRKH is unknown up to date. The homeobox (HOX) genes HOXA10 and HOXA13 are involved in the development of human genitalia. In this investigation, HOXA10 and HOXA13 genes of 20 patients with the MRKH syndrome, 7 non-MRKH patients with genital malformations and 53 control women were sequenced to assess for DNA variations. A total of 14 DNA sequence variations (10 novel and 4 known) within exonic and untranslated regions were detected in HOXA10 and HOXA13 among our cohorts. Four HOXA10 and two HOXA13 DNA sequence variations were found solely in patients with genital malformations. In addition to mutations resulting in synonymous amino acid substitutions, in the HOXA10 gene a missense mutation was identified and predicted by computer analysis as probably damaging to protein function in two non-MRKH patients, one with a bicornate and the other patient with a septated uterus. A novel exonic HOXA10 cytosine deletion was also identified in a non-MRKH patient with a septate uterus and renal malformations resulting in a premature stop codon and loss of the homeodomain helix 3/4. This cytosine deletion and the missense mutation in HOXA10 were analysed by real time PCR and sequencing, respectively, in two additional larger cohorts of 103 patients with MRKH and 109 non-MRKH patients with genital malformations. No other patients were found with the cytosine deletion however one additional patient was identified regarding the missense mutation. Rare DNA sequence variations in the HOXA10 gene could contribute to the misdevelopment of female internal genitalia. PMID:23376215

Ekici, Arif B; Strissel, Pamela L; Oppelt, Patricia G; Renner, Stefan P; Brucker, Sara; Beckmann, Matthias W; Strick, Reiner

2013-01-30

152

HOXA10 and HOXA13 sequence variations in human female genital malformations including congenital absence of the uterus and vagina.  

UK PubMed Central (United Kingdom)

Congenital genital malformations occurring in the female population are estimated to be 5 per 1000 and associate with infertility, abortion, stillbirth, preterm delivery and other organ abnormalities. Complete aplasia of the uterus, cervix and upper vagina (Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome) has an incidence of 1 per 4000 female live births. The molecular etiology of congenital genital malformations including MRKH is unknown up to date. The homeobox (HOX) genes HOXA10 and HOXA13 are involved in the development of human genitalia. In this investigation, HOXA10 and HOXA13 genes of 20 patients with the MRKH syndrome, 7 non-MRKH patients with genital malformations and 53 control women were sequenced to assess for DNA variations. A total of 14 DNA sequence variations (10 novel and 4 known) within exonic and untranslated regions were detected in HOXA10 and HOXA13 among our cohorts. Four HOXA10 and two HOXA13 DNA sequence variations were found solely in patients with genital malformations. In addition to mutations resulting in synonymous amino acid substitutions, in the HOXA10 gene a missense mutation was identified and predicted by computer analysis as probably damaging to protein function in two non-MRKH patients, one with a bicornate and the other patient with a septated uterus. A novel exonic HOXA10 cytosine deletion was also identified in a non-MRKH patient with a septate uterus and renal malformations resulting in a premature stop codon and loss of the homeodomain helix 3/4. This cytosine deletion and the missense mutation in HOXA10 were analysed by real time PCR and sequencing, respectively, in two additional larger cohorts of 103 patients with MRKH and 109 non-MRKH patients with genital malformations. No other patients were found with the cytosine deletion however one additional patient was identified regarding the missense mutation. Rare DNA sequence variations in the HOXA10 gene could contribute to the misdevelopment of female internal genitalia.

Ekici AB; Strissel PL; Oppelt PG; Renner SP; Brucker S; Beckmann MW; Strick R

2013-04-01

153

Il Linguaggio della Vagina  

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Full Text Available La cultura delle masse è oggi una cultura prevalentemente visuale. Tra i segni visuali da tempo in crescita è quello, caratteristico, della depilazione pubica femminile. Originata all'interno della cultura porno come segno di passività, questa pratica si è incontrata con i simboli della pulizia, dell'igiene, del rispetto, trasformando così il proprio significato in quello di autonomia e libertà. Così le donne possono depilarsi per scopi erotici minimizzando però la valenza sessuale del gesto tramite la tendenza alla super-igiene.

Marco Menicocci

2011-01-01

154

Carcinoma of the vagina  

International Nuclear Information System (INIS)

[en] Twenty-two patients with Stage I through IV primary vaginal squamous cell carcinomas treated for cure with radiation therapy are reviewed, with particular emphasis on the relationship of dose to complications and local control. All but 2 patients received 4000 to 6000 rad whole pelvis irradiation plus at least one radium application. Local control was 91%, with an absolute 2-year disease-free survival of 82%. The degree of anaplasia was found to influence prognosis, with all local and distant failures resulting from high-grade lesions. The complication rate was modest, with no fistulae or serious bowel complications. An analysis of total dose (external plus radium) with respect to local failure and complications showed that no major complications occurred at a combined dose below 9000 rad. An analysis of the individual contributions of external irradiation and radium implants showed that all but one very minor complication occurred at a radium dose of 4000 rad or higher. From these data, overall treatment planning and total dose recommendations are made

1977-11-01

155

Self-collected vaginal swabs for the quantitative real-time polymerase chain reaction assay of Atopobium vaginae and Gardnerella vaginalis and the diagnosis of bacterial vaginosis.  

UK PubMed Central (United Kingdom)

The aim of this study was to assess the feasibility of using self-collected vaginal specimens for the quantitative real-time polymerase chain reaction (qPCR) assays of bacterial vaginosis (BV)-associated bacteria versus practitioner-collected swabs. A cross-sectional study included 190 pregnant women enrolled before 20 weeks' gestation from September 2008 to November 2009. Self- and practitioner-collected swabs were taken during the same prenatal visit for each woman, qPCR assays performed for each, and the results compared. The quantification of the human albumin gene was used as an internal control to ensure sampling quality and accurate comparisons. The level of agreement of the qPCR assays for each microorganism was calculated with the Spearman product moment correlation coefficient and the kappa statistic. In all, 370 vaginal samples (185 self- and 185 practitioner-collected swabs) had a narrow range of values for the number of albumin gene copies and a significant correlation coefficient (Spearman's rho?=?0.532; p?vaginae, 0.918 for Lactobacillus species, 0.940 for Gardnerella vaginalis; p?vaginae (?10(8) copies/mL; kappa value?=?0.973; p?vaginae.

Menard JP; Fenollar F; Raoult D; Boubli L; Bretelle F

2012-04-01

156

Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis  

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Full Text Available Abstract Background The pathogenesis of bacterial vaginosis remains largely elusive, although some microorganisms, including Gardnerella vaginalis, are suspected of playing a role in the etiology of this disorder. Recently culture-independent analysis of microbial ecosystems has proven its efficacy in characterizing the diversity of bacterial populations. Here, we report on the results obtained by combining culture and PCR-based methods to characterize the normal and disturbed vaginal microflora. Results A total of 150 vaginal swab samples from healthy women (115 pregnant and 35 non-pregnant) were categorized on the basis of Gram stain of direct smear as grade I (n = 112), grade II (n = 26), grade III (n = 9) or grade IV (n = 3). The composition of the vaginal microbial community of eight of these vaginal swabs (three grade I, two grade II and three grade III), all from non-pregnant women, were studied by culture and by cloning of the 16S rRNA genes obtained after direct amplification. Forty-six cultured isolates were identified by tDNA-PCR, 854 cloned 16S rRNA gene fragments were analysed of which 156 by sequencing, yielding a total of 38 species, including 9 presumptively novel species with at least five species that have not been isolated previously from vaginal samples. Interestingly, cloning revealed that Atopobium vaginae was abundant in four out of the five non-grade I specimens. Finally, species specific PCR for A. vaginae and Gardnerella vaginalis pointed to a statistically significant co-occurrence of both species in the bacterial vaginosis samples. Conclusions Although historically the literature regarding bacterial vaginosis has largely focused on G. vaginalis in particular, several findings of this study – like the abundance of A. vaginae in disturbed vaginal microflora and the presence of several novel species – indicate that much is to be learned about the composition of the vaginal microflora and its relation to the etiology of BV.

Verhelst Rita; Verstraelen Hans; Claeys Geert; Verschraegen Gerda; Delanghe Joris; Van Simaey Leen; De Ganck Catharine; Temmerman Marleen; Vaneechoutte Mario

2004-01-01

157

Rhabdomyosarcoma of the urinary bladder and vagina: a clinicopathologic study with emphasis on recurrent disease: a report from the Kiel Pediatric Tumor Registry and the German CWS Study.  

Science.gov (United States)

Rhabdomyosarcomas (RMS) of the urinary bladder and vagina vary in their biologic and clinical behavior and require different types of treatment. Anatomically the two organs are close, and the reason for these differences in behavior is unknown. We investigated tumor specimens of 51 urinary bladder RMS and 14 vaginal RMS with regard to histologic subtype, growth pattern, differentiation, and proliferation morphologically and immunohistochemically. Recurrences and/or "second look" specimens from 15 patients after chemotherapy were compared with the primary tumors. Within the 65 specimens we found 31 "classical" embryonal RMS, 26 embryonal RMS of botryoid subtype (BRMS), 3 embryonal RMS of spindle cell subtype, and 5 alveolar RMS. BRMS is more common in the vagina (11 BRMS of 14 cases) than in the urinary bladder RMS (15 BRMS of 54 cases). Classical embryonal RMS with a polypoid (exophytic) growth pattern is associated with a more favorable prognosis (92% 10-year survival) than the same type with a diffuse intramural (endophytic) growth pattern (68% 10-year survival, p = 0.02). The proliferation rate was associated with the degree of differentiation, but neither showed a correlation with prognosis. A marked maturation after chemotherapy was seen in the majority of recurrences and SL specimens, associated with lowered proliferation activity. Two of 12 patients with recurrences showing chemotherapy-induced maturation died of the disease. In conclusion, we determined that polypoid embryonal RMS of both the urinary bladder and the vagina have a comparably good prognosis. This includes all botryoid RMS. The poorer prognosis of the group of urinary bladder RMS as a whole was caused by a high incidence of diffusely growing RMS, which have a less favorable prognosis than polypoid RMS. Maturation after chemotherapy occurs frequently in RMS. In contrast to the excellent prognosis reported in other studies, we had two patients with fatal outcome despite chemotherapy-induced maturation in the recurrences. PMID:11420456

Leuschner, I; Harms, D; Mattke, A; Koscielniak, E; Treuner, J

2001-07-01

158

Clinicopathological study of 112 cases of benign, pre-invasive and invasive lesions of the vagina: a 15-year review.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Benign vaginal lesions are mainly asymptomatic and often diagnosed during routine screening gynecological examinations. Additionally, vaginal intraepithelial lesions are asymptomatic and diagnosis is often confirmed after vaginal biopsy under colposcopic evaluation in cases of abnormal cytological Papanicolaou examination or synchronous cervical intraepithelial neoplasia. On the other hand, primary vaginal cancer is rare representing approximately 1-2% of all gynecological cancers. Metastatic invasion of the vagina is common especially in cases of advanced stage cervical cancer. The aim of this study was to examine the diagnostic approach, the management strategy, and the pathological findings in cases of benign, pre-invasive and invasive vaginal lesions that were diagnosed and treated in our Department. MATERIALS AND METHODS: This was a 15-year retrospective study. Cases of benign, pre-invasive, and invasive vaginal lesions diagnosed during the last fifteen years at Aretaieion Hospital of the University of Athens, were analyzed. RESULTS: During this study period 40 cases of vaginal cysts (35.7% of all vaginal lesions) were diagnosed. Surgical excision of the lesions was decided in all cases and histology showed that the most frequent cyst type was mucus-secreting Mullerian (30%). During the study period, 23 cases of vaginal intraepithelial neoplasia (VAIN, 20.5% of all vaginal lesions) were detected. In 43.5% of the cases, histological diagnosis revealed low grade VAIN, while the remaining cases were classified as high grade VAIN. Furthermore, 11 cases of primary vaginal cancer (9.8% of all vaginal lesions) were diagnosed. The vast majority of them (91%) were squamous cell carcinomas. Additionally, histology confirmed the diagnosis of metastatic invasion of the vaginal wall in 38 cases (34% of all vaginal lesions). In the majority of these cases (55.2%), primary cancer was located in the cervix. DISCUSSION: Benign, pre-invasive and invasive vaginal lesions are relatively uncommon and usually accompany lesions in other sites of the lower genital tract. Their diagnosis is based on gynecological or colposcopical examination. Treatment depends on the type of the lesion and the progression of the disease.

Kondi-Pafiti A; Grigoriadis C; Kalampokas T; Filippidou A; Salakos N; Hassiakos D

2012-01-01

159

Self-collected vaginal swabs for the quantitative real-time polymerase chain reaction assay of Atopobium vaginae and Gardnerella vaginalis and the diagnosis of bacterial vaginosis.  

Science.gov (United States)

The aim of this study was to assess the feasibility of using self-collected vaginal specimens for the quantitative real-time polymerase chain reaction (qPCR) assays of bacterial vaginosis (BV)-associated bacteria versus practitioner-collected swabs. A cross-sectional study included 190 pregnant women enrolled before 20 weeks' gestation from September 2008 to November 2009. Self- and practitioner-collected swabs were taken during the same prenatal visit for each woman, qPCR assays performed for each, and the results compared. The quantification of the human albumin gene was used as an internal control to ensure sampling quality and accurate comparisons. The level of agreement of the qPCR assays for each microorganism was calculated with the Spearman product moment correlation coefficient and the kappa statistic. In all, 370 vaginal samples (185 self- and 185 practitioner-collected swabs) had a narrow range of values for the number of albumin gene copies and a significant correlation coefficient (Spearman's rho?=?0.532; p?Gardnerella vaginalis; p?vaginae (?10(8) copies/mL; kappa value?=?0.973; p?vaginae. PMID:21789604

Menard, J-P; Fenollar, F; Raoult, D; Boubli, L; Bretelle, F

2011-07-26

160

Histologia e morfometria das glândulas das junções infundíbulo-magno e útero-vagina de codorna doméstica Histology and morphometry of the infundibulum-magnum and uterus-vaginal junctions of spotted quails  

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Full Text Available A análise comparativa das glândulas armazenadoras de espermatozóides das junções infundíbulo-magno e útero-vagina do oviduto da codorna Nothura maculosa foi realizada durante a fase reprodutiva. As aves foram eutanasiadas por inalação com éter etílico, após a pesagem. Após a laparotomia e o deslocamento cranial do esterno, foram coletadas amostras de dois centímetros da junção infundíbulo-magno e útero-vagina. Os fragmentos foram fixados em solução de Bouin por 24 horas e, posteriormente, banhos sucessivos de álcool 70% foram aplicados sobre as amostras. Em seguida, as amostras foram desidratadas em uma série de concentração crescente de alcoóis (80, 90, 95 e 3x100%), diafanizadas em xilol e incluídas em parafina. Cortes histológicos de sete micrômetros de espessura foram obtidos e corados pela técnica da Hematoxilina-eosina (HE), que foram analisados e fotomicrografados em um fotomicroscópio Olympus BX-50. Para a análise morfométrica, foram capturadas imagens das glândulas armazenadoras de espermatozóides da junção infundíbulo-magno e útero-vagina mediante o programa computacional "Image Pro Plus 4.1" da Cibernetics do Brasil, tornando-se possível a quantificação das mesmas. A mucosa da junção infundíbulo-magno apresentou pregas estreitas no infundíbulo e largas no magno, enquanto na junção útero-vagina mostrou-se amplamente pregueada na vagina e mais lisa na porção uterina. O número médio de glândulas armazenadoras de espermatozóides na junção infundíbulo-magno foi maior (11,7 glândulas) (PThe comparative analysis of sperm-host glands of infundibulum-magnum and uterus-vagina junctions of Nothura maculosa quail oviduct was done during the reproductive phase. The birds were euthanized with ethyl ether after weight data were taken. After abdominal laparotomy and cranial displacement of the breastbone, two centimeters samples of infundibulum-magnum and uterus-vagina junctions were collected. The samples were fixed in Bouin's solution for twenty four hours and later, successive baths of alcohol 70% were applied on samples and soon afterwards dehydrated in a series of grow concentration alcohols (80, 90, 95 and 3x100%), diaphanized in xylol and included on paraffin. Histological sections with seven micrometers thickness were obtained and stained on Haematoxylin-Eosin (HE) technique, then they were analyzed and photomicrographed in a photomicroscope Olympus BX-50. For the morphometry analysis, infundibulum-magnum junctions and uterus-vagina sperm host gland images were captured through a computacional program Image Pro Plus 4.1", Cibernetics Brazil, making it possible to quantify them. The mucosa of the infundibulum-magnum junction presented very narrow folds in the infundibulum and too large in the magnum, while in the uterus-vagina junction was observed widely folds mucous in the vagina and smoother in the uterine portion. The average of sperm host gland in the infundibulum-magnum junction was higher (11.7 glands) (P<0.01) compared to the uterus-vagina junction (7.5 glands). It is supposed that the abundance number of sperm host glands in infundibulum-magnum junction allows faster access of the oocyte, after the ovulation of the host spermatozoid ensuring the fertilization.

Carime Moraes; Silvana Martinez Baraldi-Artoni; Maria Rita Pacheco; Daniela Oliveira; Lizandra Amoroso; Alex Luís Sagula

2009-01-01

 
 
 
 
161

Double vagina and cervix communicating bilaterally with a single uterine cavity: report of a case with an unusual congenital uterine malformation.  

UK PubMed Central (United Kingdom)

BACKGROUND: The existence of a longitudinal vaginal septum with double cervix communicating bilaterally with a nonseptate uterine body and normal adnexa is an unusual müllerian anomaly. CASE: A 43-year-old woman presented with menorrhagia and duplication of the cervix and vagina. Afibromatous uterus was suggested by clinical examination and confirmed by ultrasonography. The patient underwent total abdominal hysterectomy with bilateral salpingooophorectomy. The surgical specimen revealed a fibromatous uterus with double cervix communicating bilaterally with a nonseptate uterine body; both adnexa were normal. CONCLUSION: This rare müllerian anomaly is inconsistent with the classical embryologic theory of caudal to cranial müllerian development but supports the alternative embryologic hypothesis suggested by Müller et al, according to which fusion and absorption begin at the isthmus and proceed simultaneously in both the cranial and caudal directions.

Varras M; Akrivis C; Demou A; Kitsiou E; Antoniou N

2007-03-01

162

The transcription of the neuD gene is stronger in serotype III group B streptococci strains isolated from cerebrospinal fluid than in strains isolated from vagina.  

UK PubMed Central (United Kingdom)

Group B streptococci (GBS) are a major cause of neonatal meningitis, and sialic acid is a determinant of the development of meningitis. The transcription level of the neuD gene, used as a marker of neu gene expression and capsular production, were significantly higher in serotype III GBS strains isolated from meningitis than from vaginal carriage. This was irrespective both of the phylogenetic position of strains and of the presence of a thymine at position 264 in the neuD gene. Differences in neuD gene transcription may explain in part why particular isolates among the GBS strains colonizing the vagina can cause meningitis. This article is protected by copyright. All rights reserved.

Pailhories H; Quentin R; Lartigue MF

2013-10-01

163

Effects of depomedroxyprogesterone acetate on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats (Rattus norvegicus)  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O objetivo do presente estudo foi determinar os efeitos do acetato de depomedroxyprogesterona (ADMP) no desenvolvimento e manutenção de Candida albicans na vagina de ratas Wistar ooferectomizadas. Os animais foram divididos em grupos controle negativos (GCN), que receberam injeções de salina estéril; grupos controle positivos (GCP), que receberam injeções de valerato de estradiol; e grupos progesterona (GP), nos quais foram feitas injeções de Depo-Provera®. Apó (more) s uma semana da aplicação hormonal, foi induzida a infecção vaginal por C. albicans em todos os grupos, detectada por cultura para leveduras vaginais e esfregaço de Papanicolaou. Foram feitas ainda imagens por microscopia eletrônica de varredura e transmissão para confirmar a infecção pela levedura no GP. Foram observados diferentes níveis de progesterona em GP, entre os valores basais e após a indução hormonal (P Abstract in english The objective of this study was to determine the effect of medroxyprogesterone acetate (DMPA) on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats. The animals were divided into negative control groups (NCG), which received injections of sterile saline; positive control groups (PCG), which were given injections of estradiol valerate; and progesterone groups (PG), which were given injections of Depo-Provera®. After one week o (more) f hormonal induction, vaginal infection by C. albicans was induced in all the groups and detected by vaginal yeast culture and Papanicolaou smear. In addition, scanning and transmission electron microscopy images were obtained to confirm the vaginal infection by yeast in PG. A difference in progesterone levels in PG was observed between the basal level and after hormonal induction (P

Storti-Filho, Agenor; Damke, Edilson; Carrara, Márcia Aparecida; Batista, Marcia Regina; Donatti, Lucélia; Boer, Cinthia Gandolfi; Svizdinski, Terezinha Inez Estivalet; Consolaro, Márcia Edilaine Lopes

2011-03-01

164

Histologia e morfometria das glândulas das junções infundíbulo-magno e útero-vagina de codorna doméstica/ Histology and morphometry of the infundibulum-magnum and uterus-vaginal junctions of spotted quails  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A análise comparativa das glândulas armazenadoras de espermatozóides das junções infundíbulo-magno e útero-vagina do oviduto da codorna Nothura maculosa foi realizada durante a fase reprodutiva. As aves foram eutanasiadas por inalação com éter etílico, após a pesagem. Após a laparotomia e o deslocamento cranial do esterno, foram coletadas amostras de dois centímetros da junção infundíbulo-magno e útero-vagina. Os fragmentos foram fixados em solução de (more) Bouin por 24 horas e, posteriormente, banhos sucessivos de álcool 70% foram aplicados sobre as amostras. Em seguida, as amostras foram desidratadas em uma série de concentração crescente de alcoóis (80, 90, 95 e 3x100%), diafanizadas em xilol e incluídas em parafina. Cortes histológicos de sete micrômetros de espessura foram obtidos e corados pela técnica da Hematoxilina-eosina (HE), que foram analisados e fotomicrografados em um fotomicroscópio Olympus BX-50. Para a análise morfométrica, foram capturadas imagens das glândulas armazenadoras de espermatozóides da junção infundíbulo-magno e útero-vagina mediante o programa computacional "Image Pro Plus 4.1" da Cibernetics do Brasil, tornando-se possível a quantificação das mesmas. A mucosa da junção infundíbulo-magno apresentou pregas estreitas no infundíbulo e largas no magno, enquanto na junção útero-vagina mostrou-se amplamente pregueada na vagina e mais lisa na porção uterina. O número médio de glândulas armazenadoras de espermatozóides na junção infundíbulo-magno foi maior (11,7 glândulas) (P Abstract in english The comparative analysis of sperm-host glands of infundibulum-magnum and uterus-vagina junctions of Nothura maculosa quail oviduct was done during the reproductive phase. The birds were euthanized with ethyl ether after weight data were taken. After abdominal laparotomy and cranial displacement of the breastbone, two centimeters samples of infundibulum-magnum and uterus-vagina junctions were collected. The samples were fixed in Bouin's solution for twenty four hours and l (more) ater, successive baths of alcohol 70% were applied on samples and soon afterwards dehydrated in a series of grow concentration alcohols (80, 90, 95 and 3x100%), diaphanized in xylol and included on paraffin. Histological sections with seven micrometers thickness were obtained and stained on Haematoxylin-Eosin (HE) technique, then they were analyzed and photomicrographed in a photomicroscope Olympus BX-50. For the morphometry analysis, infundibulum-magnum junctions and uterus-vagina sperm host gland images were captured through a computacional program Image Pro Plus 4.1", Cibernetics Brazil, making it possible to quantify them. The mucosa of the infundibulum-magnum junction presented very narrow folds in the infundibulum and too large in the magnum, while in the uterus-vagina junction was observed widely folds mucous in the vagina and smoother in the uterine portion. The average of sperm host gland in the infundibulum-magnum junction was higher (11.7 glands) (P

Moraes, Carime; Baraldi-Artoni, Silvana Martinez; Pacheco, Maria Rita; Oliveira, Daniela; Amoroso, Lizandra; Sagula, Alex Luís

2009-04-01

165

Effects of depomedroxyprogesterone acetate on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats (Rattus norvegicus)  

Directory of Open Access Journals (Sweden)

Full Text Available The objective of this study was to determine the effect of medroxyprogesterone acetate (DMPA) on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats. The animals were divided into negative control groups (NCG), which received injections of sterile saline; positive control groups (PCG), which were given injections of estradiol valerate; and progesterone groups (PG), which were given injections of Depo-Provera®. After one week of hormonal induction, vaginal infection by C. albicans was induced in all the groups and detected by vaginal yeast culture and Papanicolaou smear. In addition, scanning and transmission electron microscopy images were obtained to confirm the vaginal infection by yeast in PG. A difference in progesterone levels in PG was observed between the basal level and after hormonal induction (PO objetivo do presente estudo foi determinar os efeitos do acetato de depomedroxyprogesterona (ADMP) no desenvolvimento e manutenção de Candida albicans na vagina de ratas Wistar ooferectomizadas. Os animais foram divididos em grupos controle negativos (GCN), que receberam injeções de salina estéril; grupos controle positivos (GCP), que receberam injeções de valerato de estradiol; e grupos progesterona (GP), nos quais foram feitas injeções de Depo-Provera®. Após uma semana da aplicação hormonal, foi induzida a infecção vaginal por C. albicans em todos os grupos, detectada por cultura para leveduras vaginais e esfregaço de Papanicolaou. Foram feitas ainda imagens por microscopia eletrônica de varredura e transmissão para confirmar a infecção pela levedura no GP. Foram observados diferentes níveis de progesterona em GP, entre os valores basais e após a indução hormonal (P<0,0001). Neste grupo, 100,0% das ratas contraíram a infecção vaginal na primeira semana, mas não a mantiveram até a terceira semana. A forma farmacêutica de ADMP foi efetiva em induzir as fases de metaestro e diestro do ciclo estral das ratas, da mesma forma que usando progesterona pura. Em contraste com o que ocorre no tratamento com estrógeno, a progesterona não pôde manter a infecção vaginal experimental por C. albicans por um período significativo de tempo.

Agenor Storti-Filho; Edilson Damke; Márcia Aparecida Carrara; Marcia Regina Batista; Lucélia Donatti; Cinthia Gandolfi Boer; Terezinha Inez Estivalet Svizdinski; Márcia Edilaine Lopes Consolaro

2011-01-01

166

Lymphoepithelioma-like carcinoma of the vagina: a case report with special reference to the immunophenotype of the tumor cells and tumor-infiltrating lymphoreticular cells.  

UK PubMed Central (United Kingdom)

Lymphoepithelial carcinoma (Schmincke's tumor) is a relatively common malignancy in the upper respiratory tract (nasopharynx), but it rarely occurs at other sites. We describe here the first case of a vaginal neoplasm that closely resembled lymphoepithelial carcinoma in its histological features and immunophenotype. The tumor was detected in an 81-year-old woman who presented with recurrent vaginal bleeding. On colposcopy, an ulcerated polypoid tumor mass was seen in the posterior wall of the middle portion of the vagina. Histologic examination revealed an undifferentiated spindle-cell carcinoma (KL1+, chromogranin A-, vimentin-) with abundant lymphocytes (mostly UCHL1+ T cells), plasma cells, and macrophages (CD68+) in and around the tumor cell nests. A minority of the tumor cells exhibited overexpression of p53 protein and a quarter of the tumor cells reacted with the antibody MIB1, that is, were in a proliferate state. The tumor cells did not react with the monoclonal antibody DAKO-EBV, which detects a latent membrane protein (LMP-1) encoded by the Epstein-Barr virus. The tumor underwent regression after radiotherapy. No signs of recurrence or dissemination of the carcinoma have been detected clinically during the 6 months since treatment.

Dietl J; Horny HP; Kaiserling E

1994-04-01

167

Citologia Hormonal do Trato Urinário Baixo e da Vagina de Mulheres na Pós-menopausa, antes e durante Estrogenioterapia Oral e Transdérmica/ Urinary and Vaginal Cytology of Postmenopausal Women with Oral and Transdermal Estrogen Replacement  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Objetivo: avaliar a ação dos estrogênios por via oral ou transdérmica nas células do trato urinário baixo e da vagina, em mulheres menopausadas. Métodos: foram incluídas 25 mulheres na pós-menopausa, nas quais se estudaram os efeitos citológicos da terapia de reposição hormonal estrogênica, por via oral e por via transdérmica, sobre as células da vagina e do sedimento urinário. As pacientes foram distribuídas aleatoriamente em 2 grupos: Grupo I, constitu? (more) ?do por 14 mulheres que receberam 0,625 mg de estrogênio conjugado eqüino associado a 5 mg de acetato de medroxiprogesterona, por via oral, diariamente sem intervalo por três meses, e Grupo II, formado por 11 mulheres que fizeram uso de 17-beta-estradiol matricial na dose de 50 mig, por via transdérmica, semanalmente, associado a 5 mg de acetato de medroxiprogesterona diariamente por três meses. As amostras urinárias foram obtidas do jato inicial da primeira urina da manhã, após asseio dos genitais, em frascos estéreis fornecidos pelo laboratório. A urina foi centrifugada e o esfregaço realizado a partir do sedimento urinário. Os esfregaços da vagina e do sedimento urinário foram imediatamente fixados em álcool absoluto e corados pelo método de Shorr. Resultados: observou-se que nas pacientes que utilizaram a via oral, houve maturação das células da vagina (o índice se elevou de 45,4 a 65,5 com dois meses de tratamento, permanecendo praticamente constante (62,0) a seguir. Quanto às células urinárias, não houve variação do valor de maturação (56,4 antes da medicação e 60,4 no final do período). Ao examinarmos tanto as células da urina quanto da vagina de pacientes que utilizaram a via transdérmica, notou-se que houve resposta satisfatória. Conclusão: com estes resultados podemos sugerir que os estrogênios, quando administrados por via transdérmica, estão associados à resposta satisfatória quanto ao trofismo tanto na vagina quanto na uretra. No entanto, quando se utiliza a via oral, nem sempre este resultado pode ser observado. Abstract in english Objective: to study the effects of oral or transdermal estrogen replacement on the lower urinary tract and vagina in postmenopausal women. Methods: we studied 25 postmenopausal women evaluating the oral or transdermic estrogen replacement effects on the vaginal cells and urinary sediment during 3 months. The patients were randomly distributed into 2 groups: Group I, n = 14, treated orally with 0.625 mg equine conjugated estrogen plus 5 mg medroxyprogesterone acetate, dail (more) y for 3 months; Group II, n = 11, treated transdermally with 50 mug 17-ß-estradiol, once a week, plus 5 mg medroxyprogesterone. Daily, for 3 months, urinary samples were collected from the first miction in the morning after urogenital antisepsis into sterile tubes. The sample was centrifuged and the sediment was smeared. Vaginal and urinary smears were then fixed in absoluted alcohol and stained by the method of Shorr. Results: the patients who used the oral route presented maturation of the vaginal cells (from 45.4 to 65.5% after 2 months of treatment, maintaing 62% afterwards) but this did not occur with urinary cells (56.4 before treatment versus 60.4% at the end of the period). The transdermal route promoted maturation of vaginal and urinary cells. Conclusion: we have concluded that transdermal estrogens have satisfactory effects both on vaginal and urethral sites. However, with the oral route we did not find the expected results in the urinary tract in all cases.

Lustosa, Áurea Belas; Girão, Manoel João Batista Castello; Sartori, Marair Gracio Ferreira; Baracat, Edmund Chada; Lima, Geraldo Rodrigues de

2002-10-01

168

Citologia Hormonal do Trato Urinário Baixo e da Vagina de Mulheres na Pós-menopausa, antes e durante Estrogenioterapia Oral e Transdérmica Urinary and Vaginal Cytology of Postmenopausal Women with Oral and Transdermal Estrogen Replacement  

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Full Text Available Objetivo: avaliar a ação dos estrogênios por via oral ou transdérmica nas células do trato urinário baixo e da vagina, em mulheres menopausadas. Métodos: foram incluídas 25 mulheres na pós-menopausa, nas quais se estudaram os efeitos citológicos da terapia de reposição hormonal estrogênica, por via oral e por via transdérmica, sobre as células da vagina e do sedimento urinário. As pacientes foram distribuídas aleatoriamente em 2 grupos: Grupo I, constituído por 14 mulheres que receberam 0,625 mg de estrogênio conjugado eqüino associado a 5 mg de acetato de medroxiprogesterona, por via oral, diariamente sem intervalo por três meses, e Grupo II, formado por 11 mulheres que fizeram uso de 17-beta-estradiol matricial na dose de 50 mig, por via transdérmica, semanalmente, associado a 5 mg de acetato de medroxiprogesterona diariamente por três meses. As amostras urinárias foram obtidas do jato inicial da primeira urina da manhã, após asseio dos genitais, em frascos estéreis fornecidos pelo laboratório. A urina foi centrifugada e o esfregaço realizado a partir do sedimento urinário. Os esfregaços da vagina e do sedimento urinário foram imediatamente fixados em álcool absoluto e corados pelo método de Shorr. Resultados: observou-se que nas pacientes que utilizaram a via oral, houve maturação das células da vagina (o índice se elevou de 45,4 a 65,5 com dois meses de tratamento, permanecendo praticamente constante (62,0) a seguir. Quanto às células urinárias, não houve variação do valor de maturação (56,4 antes da medicação e 60,4 no final do período). Ao examinarmos tanto as células da urina quanto da vagina de pacientes que utilizaram a via transdérmica, notou-se que houve resposta satisfatória. Conclusão: com estes resultados podemos sugerir que os estrogênios, quando administrados por via transdérmica, estão associados à resposta satisfatória quanto ao trofismo tanto na vagina quanto na uretra. No entanto, quando se utiliza a via oral, nem sempre este resultado pode ser observado.Objective: to study the effects of oral or transdermal estrogen replacement on the lower urinary tract and vagina in postmenopausal women. Methods: we studied 25 postmenopausal women evaluating the oral or transdermic estrogen replacement effects on the vaginal cells and urinary sediment during 3 months. The patients were randomly distributed into 2 groups: Group I, n = 14, treated orally with 0.625 mg equine conjugated estrogen plus 5 mg medroxyprogesterone acetate, daily for 3 months; Group II, n = 11, treated transdermally with 50 mug 17-ß-estradiol, once a week, plus 5 mg medroxyprogesterone. Daily, for 3 months, urinary samples were collected from the first miction in the morning after urogenital antisepsis into sterile tubes. The sample was centrifuged and the sediment was smeared. Vaginal and urinary smears were then fixed in absoluted alcohol and stained by the method of Shorr. Results: the patients who used the oral route presented maturation of the vaginal cells (from 45.4 to 65.5% after 2 months of treatment, maintaing 62% afterwards) but this did not occur with urinary cells (56.4 before treatment versus 60.4% at the end of the period). The transdermal route promoted maturation of vaginal and urinary cells. Conclusion: we have concluded that transdermal estrogens have satisfactory effects both on vaginal and urethral sites. However, with the oral route we did not find the expected results in the urinary tract in all cases.

Áurea Belas Lustosa; Manoel João Batista Castello Girão; Marair Gracio Ferreira Sartori; Edmund Chada Baracat; Geraldo Rodrigues de Lima

2002-01-01

169

MRSA: rare in the vagina.  

UK PubMed Central (United Kingdom)

STUDY OBJECTIVE: To determine the prevalence of vaginal Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in sexually active adolescent women. DESIGN: A prospective surveillance study. PARTICIPANTS: Patients included 315 sexually active young women (ages 13-24) undergoing routine pelvic examination and wet mount testing in an urban teen health center. MAIN OUTCOME MEASURES: Prevalence of vaginal S. aureus and MRSA. RESULTS: S. aureus was present in 16 samples for a point estimate of 5.1% (95% CI: 2.6%-7.5%). MRSA was detected in two samples, giving a vaginal prevalence estimate of 0.6% (95% CI: 0.0% -1.5%). No differences were detected in the prevalence of S. aureus by age or race, although no cases of S. aureus were observed in those under age 15. CONCLUSION: The prevalence of MRSA in a sample of sexually active adolescents was as rare as reported in other populations. It is unlikely that vaginal MRSA is a reservoir for community acquired infections.

Huppert JS; Bennett K; Kollar LM; Pattullo L; Mortensen JE

2011-10-01

170

Estrogen and the irradiated vagina  

International Nuclear Information System (INIS)

[en] The vaginal response of patients to estrogen therapy following radiotherapy for cervical carcinoma is discussed. The authors take exception to the statement of Abitbol and Davenport that irradiation destroys the possibility of a vaginal response to estrogen stimulation

1975-01-01

171

Prevalência de cândida na flora vaginal de mulheres atendidas num serviço de planejamento familiar Prevalence of candida in the vagina of women attended at a family planning service  

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Full Text Available RESUMO Objetivo: avaliar a prevalência de Candida sp. e a distribuição de suas espécies na flora vaginal de mulheres numa clínica de planejamento familiar. Método: estudo transversal no qual se avaliaram prospectivamente 72 mulheres não-grávidas, com ou sem queixas específicas, sendo coletadas amostras de secreção vaginal para cultura de leveduras, efetuada a medição do pH vaginal e anotados dados de achados do exame ginecológico. Resultados: leveduras pertencentes ao gênero Candida foram encontradas em 18 casos (25%). A C. albicans foi a espécie mais prevalente (77,8%) e conseqüentemente 22,2% foram não-albicans. Entre as não-albicans a espécie mais prevalente foi a C. glabrata (16,7%) seguida pela C. parapsilosis (5,6%). Prurido e ardor foram os únicos sintomas relacionados significativamente com a presença de cândida. Foi observado que a C. glabrata, ao contrário da C. albicans, não causa corrimento clinicamente verificável ao exame ginecológico. Não foram verificadas associações de alguns fatores predisponentes (idade, escolaridade e uso de contraceptivos) com a presença ou não de cândida. Conclusões: nossos resultados sugerem: a) uma alta prevalência de Candida sp. entre as mulheres (25%); b) que as espécies não-albicans desempenham um papel importante no meio vaginal; c) que prurido e ardor são os sintomas mais comuns na presença de cândida e d) que a C. glabrata não costuma causar corrimento vaginal ao exame ginecológico. Finalmente, é importante observar que nossos resultados são consistentes com o que a literatura internacional tem mostrado nos últimos anos.SUMMARY Purpose: to estimate the prevalence of Candida sp. and the distribution of its species in the vagina of women attended at a family planning Service. Methods: a cross-sectional study evaluating prospectively 72 nonpregnant women, with or without specific complaints. Samples were checked for the presence of yeast and vaginal pH. Data obtained by gynecologic examination were also recorded. Results: yeast belonging to the genus Candida was isolated from 18 (25%) patients. The most prevalent species was C. albicans (77,8%) and therefore, 22.2% were non-albicans species. The most prevalent among the non-albicans species was C. glabrata (16.7%) followed by C. parapsilosis (5.6%). The symptoms most directly associated with Candida were itching and burning. Different from the symptoms directly associated with C. albicans infection, we observed that C. glabrata does not cause vaginal discharge. There was no positive association between predisponent factors such as age, education and contraceptive method used and the presence or absence of Candida. Conclusions: our results suggest: (i) that there is a high prevalence of Candida species among women; (ii) that non-albicans species play an important role in the vaginal medium; (iii) that itching and burning are the most common symptoms in women with Candida, and (iv) C. glabrata usually does not cause vaginal discharge. Finally, it is important to emphasize that our results are consistent with the present worldwide findings.

Antônio Aleixo Neto; Júnia Soares Hamdan; Ressalla Castro Souza

1999-01-01

172

Impacts of You Gui Wan on the expression of estrogen receptors and angiogenic factors in OVX?rat vagina: A possible mechanism for the trophic effect of the formula on OVX?induced vaginal atrophy.  

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The administration of You Gui Wan (YGW) decoction has been observed to improve vaginal atrophy induced by ovariectomy (OVX) in rats. The aim of the current study was to explore the possible mechanisms underlying this effect. Following OVX, 37 Sprague Dawley female rats were randomly divided into three groups which were orally administered with YGW decoction, saline or estrogen for 11 weeks. In parallel with this, 19 normal and 17 rats with sham?surgery were used as controls. The effects of these treatments on estrogen receptors (ER) and various angiogenic factors, including vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor?1 (VEGFR?1), angiopoietin (Ang)1 and 2 and basic fibroblast growth factor (bFGF) in the vagina were compared using immunohistochemistry or quantitative polymerase chain reaction (qPCR). OVX was found to induce significant vaginal atrophy and decrease the expression of ER and various angiogenic factors when compared with the normal and sham?surgery animals (all P<0.05). Estrogen replacement and the administration of YGW decoction reversed the vaginal atrophic process. The hormonal replacement and YGW treatment recovered the protein expression of ER?? and ??, VEGF and VEGFR?1 and the mRNA levels of ER??, VEGF, VEGFR?1, Ang1 and 2, and bFGF when compared with OVX?rats with saline, normal and sham?surgery treatments (all P<0.05). Thus, it may be concluded that a possible mechanism underlying the effect of YGW on OVX?induced vaginal atrophy may be the upregulated expression of ER and various angiogenic factors in the vaginal tissue. PMID:24009028

Yin, Qiao-Zhi; Lu, Hua; Li, Li-Min; Yie, Shang-Mian; Hu, Xiang; Liu, Zhi-Bin; Zheng, Xiao; Cao, Sheng; Yao, Zou-Ying

2013-09-06

173

Bull Gore Injury of the Vagina  

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Although an obstetrically related trauma is the most common cause of the injuries to the female genital tract, non obstetric causes also lead to a significant number of vaginal and vulval injuries. We present 2 cases of vaginal injury, due to bull goring, one of which was associated with massive vul...

Kulkarni, Maitri Raghavendra; Gangadharaiah, Mahendra; Kulkarni, Sunanda R.

174

Bacterial Vaginosis, Atopobium vaginae and Nifuratel  

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As bacterial vaginosis (BV) is a potential cause of obstetric complications and gynecological disorders, there is substantial interest in establishing the most effective treatment. Standard treatment - metronidazole or clindamycin, by either vaginal or oral route – is followed by relapses in about 3...

Polatti, Franco

175

Primary invasive squamous carcinoma of the vagina  

International Nuclear Information System (INIS)

[en] Forty-three cases of primary vaginal squamous cell cancer were treated at the University of Wisconsin Hospital between 1956 and 1971. These cases comprised of 1.2% of patients admitted to the University Hospital with female genital tract cancer. Evidence is presented to support a modification of the currently accepted FIGO staging system for vaginal carcinoma (Stage II disease). Radiation therapy using both external beam and brachyradium equivalents or interstitial implantation of suitable isotopes was an effective method for the treatment of patients having early and locally advanced invasive vaginal cancer. The 5-year absolute survival rate for the entire series was 37.2%. Absolute survival rate by modified FIGO clinical staging was 66% for Stages I and IIA, 31% for Stage IIB, 25% for Stage III, and 0% for Stage IV

1979-01-01

176

Caracterización de la microbiota levaduriforme residente en la vagina de perras en diferentes fases del ciclo estral Characterization of vaginal microbiotic yeasts of bitches in distinct stages of the oestrous cycle  

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Full Text Available Hongos levaduriformes son aislados frecuentemente de los animales domésticos y silvestres, siendo algunos comensales del tegumento y mucosas. Las levaduras son frecuentes en la mucosa vaginal de las mujeres, pero en perras son escasos los estudios referentes a la microbiota fúngica vaginal, sin conocerse su relación con el ciclo reproductivo. En este estudio se buscó aislar e identificar levaduras de la microbiota vaginal de perras, y establecer si hay alteración de la microbiota levaduriforme en las fases del ciclo reproductivo. Se analizaron 75 muestras de la vagina de 75 perras de los caniles particulares (Grupo I) y 224 muestras de 14 perras experimentales (Grupo II). El ciclo estral fue determinado por citología vaginal y se registraron observaciones clínicas como sangrado, edema y pliegues de vulva. Las muestras fueron sometidas a examen directo y cultivos en Agar-Sabouraud dextrosa con cloranfenicol, a 37 ºC por 10 días. Las levaduras fueron clasificadas por macro y micromorfología, pruebas bioquímicas, tubo germinativo y microcultivo. De las 75 muestras del grupo I, el aislamiento fue 33,3% (n = 25); las muestras fueron obtenidas en las fases de proestro 56,3%, estro 16,7%, diestro 66,7% y anestro 20,5%, respectivamente. De las 224 muestras del grupo II se aislaron levaduras en 147 (65,6%): en proestro 61,9%, estro 71,9%, diestro 82,7% y anestro 57,1%, respectivamente. Las levaduras fueron identificadas como Candida spp, Malassezia pachydermatis y Rhodoturola spp. Los resultados sugieren que estas levaduras forman parte de la microbiota vaginal de perras sanas y sus frecuencias se alteran en las fases del ciclo reproductivo.Yeasts are commensal organisms frequently isolated from the skin and mucous membranes of domestic and wild mammals. Although yeasts are frequently isolated from women’s vaginal mucus, similar studies in canine are rare, therefore their behaviour during the canine oestrous cycle is unknown. The purpose of this study was to isolate yeasts from the vaginal microbiota of bitches and to evaluate their behaviour in different stages of the oestrous cycle. We examined 75 samples of mucus from the vaginal cavity of 75 domestic bitches and 224 samples from 14 experimental bitches. The stages of the oestrous cycle were characterized through vaginal cytology and clinical observation of bleeding, vulvar oedema and pucker. Samples were examined visually, and also cultured in Sabouraud dextrose agar with chloranphenicol, at 37 ºC for 10 days. The yeasts were classified according to their macro and micro morphology, biochemical tests, germination tube and micro culture. Yeasts were isolated from 25 (33.3%) samples from domestic females. Among the samples collected during proestrous, oestrous, diestrous and anestrous, 56.3% 16.7% 66.7% and 20.5% were positive, respectively. Yeasts were isolated from 147 (65.6%) samples from experimental bitches. Among the samples collected during proestrous, oestrous, diestrous and anestrous, positive samples represented 61.9%, 71.9%, 82.7%, and 57.1%, respectively. The identified species were Candida spp, M. pachydermatis and Rhodotorula spp, which are commonly present in the vaginal mucus microbiota of healthy bitches and their frequency changes with the different stages of the oestrous cycle.

M B Cleff; M O Xavier; A A Martins; R Santin; M C A Meireles

2007-01-01

177

Primary malignant mixed Mullerian tumor of the vagina.  

UK PubMed Central (United Kingdom)

A 74-year-old woman presented with postmenopausal bleeding. Examination showed a 5.5-cm ulcerated, partly necrotic vaginal polyp arising anteriorly near the hymenal ring. Histology showed a malignant mixed Müllerian tumor (MMMT) with squamous and glandular epithelial and undifferentiated spindle cell stromal components, cytological atypia, and frequent mitoses. The tumor was closely associated with overlying vaginal intraepithelial neoplasia, grade III, from which it appeared to be arising. The patient was treated by surgical excision, followed by radiotherapy. Six months later, she developed a left supraclavicular lymph node metastasis. MMMT is a rare primary vaginal neoplasm, but, including this case, there have been at least 7 cases reported in the English language literature.

Neesham D; Kerdemelidis P; Scurry J

1998-08-01

178

Primary malignant mixed Müllerian tumor of the vagina.  

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A 74-year-old woman presented with postmenopausal bleeding. Examination showed a 5.5-cm ulcerated, partly necrotic vaginal polyp arising anteriorly near the hymenal ring. Histology showed a malignant mixed Müllerian tumor (MMMT) with squamous and glandular epithelial and undifferentiated spindle cell stromal components, cytological atypia, and frequent mitoses. The tumor was closely associated with overlying vaginal intraepithelial neoplasia, grade III, from which it appeared to be arising. The patient was treated by surgical excision, followed by radiotherapy. Six months later, she developed a left supraclavicular lymph node metastasis. MMMT is a rare primary vaginal neoplasm, but, including this case, there have been at least 7 cases reported in the English language literature. PMID:9740711

Neesham, D; Kerdemelidis, P; Scurry, J

1998-08-01

179

Didelphic uterus with imperforate unilateral vagina and ipsilateral renal agenesis: Magnetic resonance. Utero didelfo con vagina unilateral imperforada y agenesia renal ipsilateral: resonancia magnetica  

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We present two cases of didelphic uterus with the clinical appearance of a pelvic mass produced by the hematometra-hematocolpos retained by an imperforate unilateral hemivagina. In both cases, this anomaly was accompanied by ipsilateral renal agenesis. We basically review the diagnosis of this disorder, focusing on magnetic resonance as the technique of choice. (Author) 10 refs.

Rodrigo, R.M.; Saez, F.; Astigarraga, E.; Rodriguez, O. (Hospital de Cruces. Servicio de Radiodiagnostico. Baracaldo.Vizcaya (Spain))

1993-01-01

180

Didelphic uterus with imperforate unilateral vagina and ipsilateral renal agenesis: Magnetic resonance  

International Nuclear Information System (INIS)

We present two cases of didelphic uterus with the clinical appearance of a pelvic mass produced by the hematometra-hematocolpos retained by an imperforate unilateral hemivagina. In both cases, this anomaly was accompanied by ipsilateral renal agenesis. We basically review the diagnosis of this disorder, focusing on magnetic resonance as the technique of choice. (Author) 10 refs.

1993-01-01

 
 
 
 
181

Adenocarcinoma of vagina: combined surgery and radiation with preservation of genital function  

International Nuclear Information System (INIS)

A report is given of a patient treated at Memorial Hospital, New York City, by external and fractionated intravaginal radiation given after a surgical procedure that consisted of local excision of tumor, pretreatment laparotomy, and lateral ovarian transposition. The treatment plan was based on the observations that there was no evidence of local or distant spread and that the ovaries could be moved to positions where radiation exposure would not terminate their activity. The patient has survived over six years and is without evidence of recurrence

1981-01-01

182

Radiotherapy for carcinoma of the vagina. Immunocytochemical and cytofluorometric analysis of prognostic factors  

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Background and purpose: The aim of this study was to assess the potential prognostic factors in patients with primary invasive vaginal carcinoma (PIVC) treated with radical irradiation. Patients and methods: The analysis was performed on 77 patients with PIVC treated between 1985 and 2005 in the Maria Sklodowska-Curie Memorial Institute of Oncology, Cancer Center in Krakow. A total of 36 patients (46.8 %) survived 5 years with no evidence of disease (NED). The following groups of factors were assessed for potential prognostic value: population-based (age), clinical (Karnofsky Performance Score [KPS], hemoglobin level, primary location of the vaginal lesion, macroscopic type, length of the involved vaginal wall, FIGO stage), microscopic (microscopic type, grade, mitotic index, presence of atypical mitoses, lymphatic vessels invasion, lymphocytes/plasmocytes infiltration, focal necrosis, VAIN-3), immunohistochemical (protein p53 expression, MIB-1 index), cytofluorometric (ploidity, index DI, S-phase fraction, proliferation index SG2M) factors. Results: Significantly better 5-year NED was observed in patients: < 60 years, KPS {<=} 80, FIGO stage I and II, grade G1-2, MIB-1 index < 70, S-phase fraction < 10, and proliferation index < 25. Independent factors for better prognosis in the multivariate Cox analysis were age < 60 years, FIGO stage I or II, and MIB-1 index < 70. Conclusion: Independent prognostic factors in the radically irradiated PIVC patients were as follows: age, FIGO stage, MIB-1 index. (orig.)

Blecharz, P. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Gynecological Oncology; Reinfuss, M.; Jakubowicz, J. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Radiation Oncology; Rys, J. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Tumor Pathology Oncology; Skotnicki, P.; Wysocki, W. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Oncological Surgery

2013-05-15

183

Sheila Jeffreys: The Industrial Vagina. The Political Economy of the Global Sex Trade. London: Routledge 2008.  

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Full Text Available Sheila Jeffreys analysiert die Prozesse, die zu einer Industrialisierung und Globalisierung von Prostitution im späten 20. und 21. Jahrhundert geführt haben. Hauptverantwortlich für die gegenwärtige Diskursverschiebung um Prostitution ist für Jeffreys zum einen die sexuelle Revolution der 1970er Jahre und zum anderen die massive Finanzierung von Unterstützer/-innen der Sexarbeiterinnen zur HIV-Prävention in den 1980ern. Jeffreys legt wie in früheren Arbeiten ihre radikal-feministische Position dar und fordert eine Abschaffung der Prostitution. In ihrer Abrechnung mit dem liberalen feministischen Diskurs, für den eine Unterstützung von Sexarbeiterinnen prioritär ist, ignoriert sie die Widersprüchlichkeiten und Komplexitäten der gelebten Realitäten. An vielen Stellen ihres Buches bekräftigt Jeffreys stereotypische Männlichkeitsvorstellungen, was durch einen Blick über den Tellerrand des ihr vertrauten wissenschaftlichen Bezugsrahmens hätte vermieden werden können.Sheila Jeffreys analyzes the processes that led to the industrialization and globalization of prostitution in the late 20th and 21th centuries. Jeffreys considers those primary factors responsible for the current shift in discourse on prostitution, which can be attributed to the sexual revolution of the 1970s on the one hand, and to massive financing of HIV prevention in the 1980s by sex worker supporters on the other. As in earlier studies, Jeffreys presents readers with her radical-feminist position and demands prostitution be abolished. In her confrontation with liberal-feminist discourse, in which the support of sex workers takes priority, she ignores the inconsistencies and complexities of real lived experience. At many points throughout her book, Jeffreys affirms stereotypical male conceptions, which could have been avoided had she looked beyond the theoretical frame of reference that makes up her comfort zone.

Susanne Hofmann

2010-01-01

184

The influence of radium therapie on the yeast contamination of the vagina  

International Nuclear Information System (INIS)

[en] Before the beginning of radium therapy a vaginal yeast contamination of 9,7% was found of 113 patients with various genital carcinomas. However, the incidence of vaginal yeast contamination increased suddenly to 30,9% under the contac irradiation therapy with radium. The radiation effect of radium is not sufficient for a 'selfsterilisation' of the radium-carrier in the case of yeast contamination. Therefore, a chemic desinfection of the radium-carriers is principly necessary. The significance is discussed and the recommendation is made that routine mycological supervision be carried out on all patients with gynaecological carcinomas and appropriate antimycotic therapy initiated where necessary. (orig.)[de] Bei 113 Patientinnen mit verschiedenen Genitalkarzinomen wurde vor Beginn einer Radiumtherapie ein vaginaler Hefebefall von 9,7% festgestellt. Die Befallsrate war gegenueber dem Befall bei altersmaessig vergleichbaren gesunden Frauen nicht erhoeht. Unter Einfluss einer Radiumtherapie fand sich ein sprunghafter Anstieg des vaginalen Hefebefalls auf 30,9%. Es konnte belegt werden, dass die aktinische Wirkung des Radiums nicht zu einer 'Selbststerilisation' der Radiumtraeger bei Hefekontamination ausreicht. Eine chemische Desinfektion der Radiumtraeger ist demnach grundsaetzlich erforderlich. Es wird die Bedeutung der Radiumtherapie fuer die vaginale Hefebesiedlung diskutiert und die Forderung erhoben, bei gynaekologischen Karzinompatientinnen routinemaessig eine mykologische Ueberwachung und eine entsprechende antimykotische Therapie durchzufuehren. (orig.)

1979-01-01

185

[Immunoglobulins A in the vagina. Assay and study of their specificity  

UK PubMed Central (United Kingdom)

The authors have titrated, by the Laurell technique, immunoglobulin A in vaginal washings ; the quantity of IgA found is higher for women having a pathogenic vaginal flora. Using immunofluorescence technique, and peroxydase-marked antibodies, the authors found specific IgA directed against Lactobacillus, N. gonorrhoeae and Candida albicans.

Thierry RC; Wurtz A

1975-05-01

186

Radiotherapy for carcinoma of the vagina. Immunocytochemical and cytofluorometric analysis of prognostic factors.  

UK PubMed Central (United Kingdom)

BACKGROUND AND PURPOSE: The aim of this study was to assess the potential prognostic factors in patients with primary invasive vaginal carcinoma (PIVC) treated with radical irradiation. PATIENTS AND METHODS: The analysis was performed on 77 patients with PIVC treated between 1985 and 2005 in the Maria Sk?odowska-Curie Memorial Institute of Oncology, Cancer Center in Krakow. A total of 36 patients (46.8?%) survived 5 years with no evidence of disease (NED). The following groups of factors were assessed for potential prognostic value: population-based (age), clinical (Karnofsky Performance Score [KPS], hemoglobin level, primary location of the vaginal lesion, macroscopic type, length of the involved vaginal wall, FIGO stage), microscopic (microscopic type, grade, mitotic index, presence of atypical mitoses, lymphatic vessels invasion, lymphocytes/plasmocytes infiltration, focal necrosis, VAIN-3), immunohistochemical (protein p53 expression, MIB-1 index), cytofluorometric (ploidity, index DI, S-phase fraction, proliferation index SG2M) factors. RESULTS: Significantly better 5-year NED was observed in patients:

Blecharz P; Reinfuss M; Ry? J; Jakubowicz J; Skotnicki P; Wysocki W

2013-05-01

187

The microbiota of the vagina and its influence on women's health and disease.  

UK PubMed Central (United Kingdom)

Explorations of the vaginal microbiota (VMB) began over 150 years ago. Using light microscopy and bacterial cultures, the concept of normal versus abnormal microbiota in women began to emerge. The latter became known by the term "bacterial vaginosis" (BV). BV microbiota is dominated by Gardnerella vaginalis and includes a number of anaerobic organisms. In contrast, normal flora is dominated by various Lactobacilli. BV microbiota is associated with vaginal discharge, poor pregnancy outcomes, pelvic inflammatory disease, postoperative wound infections and endometritis after elective abortions. In addition, BV flora predisposes women to infection by human immunodeficiency virus and sexually transmitted diseases. Application of molecular techniques over the past decade has significantly advanced our understanding of the VMB. It is far more complex than previously recognized and is composed of many previously unknown organisms in addition to those already identified by culture. Analyses using high-throughput sequencing techniques have revealed unique microbial communities not previously recognized within the older, established vaginal flora categories. These new findings will inform the design of future clinical investigations of the role of the VMB in health and disease.

Martin DH

2012-01-01

188

The microbiota of the vagina and its influence on women's health and disease.  

Science.gov (United States)

Explorations of the vaginal microbiota (VMB) began over 150 years ago. Using light microscopy and bacterial cultures, the concept of normal versus abnormal microbiota in women began to emerge. The latter became known by the term "bacterial vaginosis" (BV). BV microbiota is dominated by Gardnerella vaginalis and includes a number of anaerobic organisms. In contrast, normal flora is dominated by various Lactobacilli. BV microbiota is associated with vaginal discharge, poor pregnancy outcomes, pelvic inflammatory disease, postoperative wound infections and endometritis after elective abortions. In addition, BV flora predisposes women to infection by human immunodeficiency virus and sexually transmitted diseases. Application of molecular techniques over the past decade has significantly advanced our understanding of the VMB. It is far more complex than previously recognized and is composed of many previously unknown organisms in addition to those already identified by culture. Analyses using high-throughput sequencing techniques have revealed unique microbial communities not previously recognized within the older, established vaginal flora categories. These new findings will inform the design of future clinical investigations of the role of the VMB in health and disease. PMID:22143133

Martin, David H

2012-01-01

189

Minimal criteria for the identification of Gardnerella vaginalis isolated from the vagina.  

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Vaginal swabs were examined for the presence of Gardnerella vaginalis. Of 294 isolates with appropriate colonial and cellular morphology subjected to an identification procedure, 203 (69%) were identified as G vaginalis. The 91 isolates not identified as G vaginalis were differentiated by their inab...

Jolly, J L

190

In vitro probiotic properties of Lactobacillus fermentum SK5 isolated from vagina of a healthy woman.  

UK PubMed Central (United Kingdom)

A lactobacillus strain isolated from a vaginal tract of a healthy woman was examined in vitro for its probiotic potential. This strain, identified as Lactobacillus fermentum SK5, was able to survive at pH 3-4 and 0.1-0.2% bile, and unaffected by pepsin (3 g l(-1)) and pancreatin (1 g l(-1)), but was susceptible to all tested antibiotics except metronidazole. L. fermentum SK5 had an antimicrobial potential against gastrointestinal pathogenic Escherichia coli and vaginal pathogenic Gardnerella vaginalis. The effective substance was suspected to be a bacteriocin-like compound with a molecular weight of more than 10 kDa, but hydrogen peroxide was also detected. Further studies revealed that L. fermentum SK5 had good autoaggregation characteristic and a high surface hydrophobicity that enhanced its adhesion ability to epithelial cells and for biofilm formation. This lactobacillus showed coaggregation with E. coli and G. vaginalis to affect their adhesion and colonization. The adhesion of L. fermentum SK5 to HeLa, HT-29 and Caco-2 cells and its inhibition of E. coli and G. vaginalis adherence to these cells were demonstrated. These incidences provided evidence of the possible colonization of L. fermentum SK5 that would prevent binding and growth of E. coli and G. vaginalis onto intestinal and vaginal epithelial cells. On the basis of the ability of L. fermentum SK5 to inhibit pathogenic microorganisms through coaggregation and antimicrobial substances, it is likely that this lactobacillus strain could be a potential probiotic candidate for beneficial use in protecting against gastrointestinal and vaginal microbial infections.

Kaewnopparat S; Dangmanee N; Kaewnopparat N; Srichana T; Chulasiri M; Settharaksa S

2013-08-01

191

Radiotherapy for carcinoma of the vagina. Immunocytochemical and cytofluorometric analysis of prognostic factors  

International Nuclear Information System (INIS)

Background and purpose: The aim of this study was to assess the potential prognostic factors in patients with primary invasive vaginal carcinoma (PIVC) treated with radical irradiation. Patients and methods: The analysis was performed on 77 patients with PIVC treated between 1985 and 2005 in the Maria Sklodowska-Curie Memorial Institute of Oncology, Cancer Center in Krakow. A total of 36 patients (46.8 %) survived 5 years with no evidence of disease (NED). The following groups of factors were assessed for potential prognostic value: population-based (age), clinical (Karnofsky Performance Score [KPS], hemoglobin level, primary location of the vaginal lesion, macroscopic type, length of the involved vaginal wall, FIGO stage), microscopic (microscopic type, grade, mitotic index, presence of atypical mitoses, lymphatic vessels invasion, lymphocytes/plasmocytes infiltration, focal necrosis, VAIN-3), immunohistochemical (protein p53 expression, MIB-1 index), cytofluorometric (ploidity, index DI, S-phase fraction, proliferation index SG2M) factors. Results: Significantly better 5-year NED was observed in patients:

2013-01-01

192

[The influence of radium therapie on the yeast contamination of the vagina (author's transl)  

UK PubMed Central (United Kingdom)

Before the beginning of radium therapy a vaginal yeast contamination of 9,7% was found of 113 patients with different genital carcinomas. However, the incidence of vaginal yeast contamination increased suddenly to 30,9% under the contac irradiation therapy with radium. The radiation effect of radium is not sufficient for a "selfsterilisation" of the radium-carrier in the case of yeast contamination. Therefore, a chemic desinfection of the radium-carriers is principly necessary. The significance of radium therapy with respect to vaginal yeast contamination is discussed and the recommendation is made that routine mycological supervision be carried out on all patients with gynaecological carcinomas and appropriate antimycotic therapy initiated where necessary.

Mendling W; Schnell JD; Spiecker R

1979-12-01

193

[The influence of radium therapie on the yeast contamination of the vagina (author's transl)].  

Science.gov (United States)

Before the beginning of radium therapy a vaginal yeast contamination of 9,7% was found of 113 patients with different genital carcinomas. However, the incidence of vaginal yeast contamination increased suddenly to 30,9% under the contac irradiation therapy with radium. The radiation effect of radium is not sufficient for a "selfsterilisation" of the radium-carrier in the case of yeast contamination. Therefore, a chemic desinfection of the radium-carriers is principly necessary. The significance of radium therapy with respect to vaginal yeast contamination is discussed and the recommendation is made that routine mycological supervision be carried out on all patients with gynaecological carcinomas and appropriate antimycotic therapy initiated where necessary. PMID:391638

Mendling, W; Schnell, J D; Spiecker, R

1979-12-01

194

Adenocarcinoma of vagina: combined surgery and radiation with preservation of genital function  

Energy Technology Data Exchange (ETDEWEB)

A report is given of a patient treated at Memorial Hospital, New York City, by external and fractionated intravaginal radiation given after a surgical procedure that consisted of local excision of tumor, pretreatment laparotomy, and lateral ovarian transposition. The treatment plan was based on the observations that there was no evidence of local or distant spread and that the ovaries could be moved to positions where radiation exposure would not terminate their activity. The patient has survived over six years and is without evidence of recurrence.

Nori, D.; Hilaris, B.S.; Lewis, J.L.

1981-11-01

195

Iterstitial gamma-therapy of recurrences and metastases of uterine and rectal cancer to the vagina  

International Nuclear Information System (INIS)

[en] A technique of interstitial radiation therapy for locally disseminated vaginal recurrences and metastases that occOr after the use of various therapeutic methods for uterine and rectal cancer is devised. Indications and coUnterindications to interstitial radiation therapy with 60Co as an independent method or the main therapeutic component in combined or multimodality treatment, were determined. Methods of the topometric and dosimetric planning of treat-- ment, methods of needle administration and fixation by the system of manual afterloading were developed. Interstitial radiation therapy was given to 22 patients with a complete tumor regression in 17 of them. Interstitial radiation therapy is recommended as a method of choice for the therapy of vaginal recurrences and metastases

1984-01-01

196

Epithelial-stromal interactions in the mouse vagina exposed neonatally to diethylstilbestrol.  

UK PubMed Central (United Kingdom)

BACKGROUND: In neonate mice exposed to diethylstilbestrol (neoDES), vaginal epithelium shows persistent proliferation and stratification even after ovariectomy. Tissue recombination studies suggest that neonatally-estrogenized vaginal stroma can induce vaginal epithelial hyperplasia depending on the stromal age. This study examined the proliferative effect of the vaginal stroma from 8-day-old mice treated with DES on the vaginal epithelia of 8-day-old and adult mice. MATERIALS AND METHODS: Vaginal epithelium and stroma from 8-day-old and adult mice was recombined, and grafted to ovariectomized host mice. RESULTS: The 5-bromo-2'-deoxyuridine (BrdU)-labeled cells in the epithelium and the number of epithelial cell layers were not significantly different between epithelia from 8-day-old and adult mice when combined with stroma from 8-day-old control mice. BrdU-labeled cells in the vaginal epithelia from both age groups combined with the stroma from 8-day-old neoDES mice exhibited higher values. The epithelium from neoDES adult mice had a lower percentage of BrdU-labeled cells. CONCLUSION: The stroma from 8-day-old neoDES mice induces epithelial cell proliferation, but lower stromal cell proliferation.

Katoh T; Hayashi S; Iguchi T; Sato T

2013-05-01

197

Section B: Malignant manifestations of HPV infection Carcinoma of the cervix, vulva, vagina, anus, and penis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Cervical cancer remains the commonest cancer among women in developing countries, affecting women at their peak of social and economic responsibility. In poor countries where access to diagnosis and treatment is extremely limited, most of the affected women present with late-stage disease. Many do n...

Denny, L; Ngan, HYS

198

Characterisation of the bacterial microbiota of the vagina of dairy cows and isolation of pediocin-producing Pediococcus acidilactici  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Uterine infections in dairy cows lower profitability of dairy operations. Infections of the reproductive tract are related to the overgrowth of pathogenic bacteria during the first three weeks after parturition. However, alterations in the vaginal microbiota comp...

Wang Yvonne; Ametaj Burim N; Ambrose Divakar J; Gänzle Michael G

199

Use of cellular depletion analysis to examine circulation of immune effector function between the vagina and the periphery.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Results from an animal model of vaginal candidiasis suggest that Candida-specific cell-mediated immunity in the systemic circulation does not mediate protection against vaginitis. The present study used cellular depletion analysis to examine the circulation of immune effector function between the va...

Fidel, P L; Luo, W; Chabain, J; Wolf, N A; Van Buren, E

200

Dissimilarities in the metabolism of antiretroviral drugs used in HIV pre-exposure prophylaxis in colon and vagina tissues.  

UK PubMed Central (United Kingdom)

Attempts to prevent HIV infection through pre-exposure prophylaxis (PrEP) include topical application of anti-HIV drugs to the mucosal sites of infection; however, a potential role for local drug metabolizing enzymes in modulating the exposure of the mucosal tissues to these drugs has yet to be explored. Here we present the first report that enzymes belonging to the cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) families of drug metabolizing enzymes are expressed and active in vaginal and colorectal tissue using biopsies collected from healthy volunteers. In doing so, we discovered that dapivirine and maraviroc, a non-nucleoside reverse transcriptase inhibitor and an entry inhibitor currently in development as microbicides for HIV PrEP, are differentially metabolized in colorectal tissue and vaginal tissue. Taken together, these data should help to guide the optimization of small molecules being developed for HIV PrEP.

To EE; Hendrix CW; Bumpus NN

2013-10-01

 
 
 
 
201

Dissimilarities in the metabolism of antiretroviral drugs used in HIV pre-exposure prophylaxis in colon and vagina tissues.  

Science.gov (United States)

Attempts to prevent HIV infection through pre-exposure prophylaxis (PrEP) include topical application of anti-HIV drugs to the mucosal sites of infection; however, a potential role for local drug metabolizing enzymes in modulating the exposure of the mucosal tissues to these drugs has yet to be explored. Here we present the first report that enzymes belonging to the cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) families of drug metabolizing enzymes are expressed and active in vaginal and colorectal tissue using biopsies collected from healthy volunteers. In doing so, we discovered that dapivirine and maraviroc, a non-nucleoside reverse transcriptase inhibitor and an entry inhibitor currently in development as microbicides for HIV PrEP, are differentially metabolized in colorectal tissue and vaginal tissue. Taken together, these data should help to guide the optimization of small molecules being developed for HIV PrEP. PMID:23965226

To, Elaine E; Hendrix, Craig W; Bumpus, Namandjé N

2013-08-18

202

Cistectomía radical laparoscópica con extracción de pieza por vagina: Caso clínico/ Laparoscopic radical cystectomy with vaginal specimen extraction: Case report  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Objetivo: Presentar la utilidad de una técnica minimamente invasiva como herramienta terapéutica en el tratamiento de un paciente de edad avanzada portador de cáncer de vejiga musculoinvasor. Método: Paciente femenina de 78 años con cáncer de vejiga avanzado que debuta con hematuria. Se realiza cistectomía radical con linfadenectomía pelviana por vía laparoscópica con extracción de pieza quirúrgica por vía vaginal. Resultados: El tiempo operatorio fue de 240 (more) minutos con un sangrado de 200 ml y una estadía hospitalaria de 8 días. La paciente evolucionó favorablemente y tras un seguimiento de 6 meses se encuentra sin evidencia de recidiva tumoral. Conclusión: El bajo impacto quirúrgico permite que este abordaje pueda ser utilizado en casos seleccionados para evitar la severa morbilidad indefectiblemente asociada a la progresión local del cáncer de vejiga avanzado. Abstract in english Objective: To report a case of laparoscopic radical cystectomy and pelvic lymphadenectomy with vaginal extraction of the surgical specimen in an elderly patient with muscle invasive bladder tumor. Method: A 78 year old patient with history of hematuria was diagnosed of muscle invasive bladder cancer. Lapa-roscopic radical cystectomy and pelvic lymphadenectomy with vaginal extraction of the surgical specimen was performed without incident. Results: Operative time was 240 m (more) inutes, surgical bleeding was 200 ml and hospital stay 8 days. The patient evolved uneventfully and remains disease free after 9 months of follow-up. Conclusion: Laparoscopic radical cystectomy provides adequate oncologic results with decreased morbidity, making this surgery an attractive alternative for the management of patients in a delicate condition.

Vitagliano, Gonzalo; Villasante, Nicolas; Paterlini, Juan; Ameri, Carlos; Mazza, Osvaldo

2009-05-01

203

Carcinoma epidermoide no queratinizante de células grandes y pequeñas en vagina Large and small cells non-keratinizing epidermoid vaginal carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available Se presentan 5 casos clínicos de pacientes atendidas en la consulta de patología de cuello del Hospital Provincial Ginecoobstétrico "Mariana Grajales Coello" de Santiago de Cuba por presentar sangrado vaginal, dolor en bajo vientre, leucorrea y lesiones vaginales. El estudio anatomopatológico confirmó el diagnóstico de carcinoma de células escamosas o epidermoide.Five case reports of patients who were assisted at the cervix Pathology Department from "Mariana Grajales Coello" Provincial Gynecological Obstetrical Hospital in Santiago de Cuba due to vaginal bleeding, low abdominal pain, leukorrhea and vaginal injuries are presented. The pathological study confirmed the diagnosis of squamous or epidermoid cells carcinoma.

Ofelia Masó Anaya; María Elena Morales Larramendi; Dolores Díaz Pérez; Esperanza Dager Dager; Gloria Adelaida Bolaños Diego

2012-01-01

204

Persistence of Lactobacillus fermentum RC-14 and Lactobacillus rhamnosus GR-1 but Not L. rhamnosus GG in the Human Vagina as Demonstrated by Randomly Amplified Polymorphic DNA  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 are well-characterized probiotic strains with efficacy in the prevention and treatment of urogenital infections in women. The aim of the present study was to apply a molecular biology-based methodology for the detection of these strains and L. rham...

Gardiner, Gillian E.; Heinemann, Christine; Bruce, Andrew W.; Beuerman, Dee; Reid, Gregor

205

Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina)  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome refers to the congenital absence or severe hypoplasia of the female genital tract, often described as uterovaginal aplasia which is the prime feature of the syndrome. It is the second cause of primary amenorrhea after gonadal dysgenesis and occurs i...

Burel, Agnès; Mouchel, Thomas; Odent, Sylvie; Tiker, Filiz; Knebelmann, Bertrand; Pellerin, Isabelle; Guerrier, Daniel

206

Interstitial microwave hyperthermia and brachytherapy for malignancies of the vulva and vagina. I: Design and testing of a modified intracavitary obturator.  

Science.gov (United States)

A vaginal obturator was fabricated to be used in combination with implanted catheters to provide microwave hyperthermia and brachytherapy to the vulva and vaginal wall. This site is difficult to heat or irradiate solely with interstitial techniques. The obturator was modified to provide grooves for the mounting of interstitial catheters into the outer wall and was matched with a template for circumferential implants. Power deposition tests were done using arrays of three microwave antenna designs: dipole (hA = hB = 3.9 cm), helical (3.9 cm coil, shorted), and modified dipole (1.0 cm helix on dipole tip) to test the performance of the obturator. The obturator and four non-obturator catheters were positioned in muscle-equivalent phantom. Two obturator catheters along with two free-standing catheters formed the obturator array. Four freestanding catheters formed the non-obturator array. Power deposition or specific absorption rate (SAR) measurements were made along the central axis, bisect, and diagonal transect of each array. SAR results showed that antennas in the obturator wall radiated as dipole theory predicts, although with less power density when compared to antennas in the same catheters spaced 1.8 cm from the obturator. This could be compensated for by increasing the power to the antennas in the obturator by 42%. Adjacent pairs of antennas were placed 90 degrees out of phase for 0.25 sec and rotated around the array. Phase rotation demonstrated that the central array SAR peaks could be lowered from 100% to 50% SAR, with dipole antennas thus resulting in lowered peak temperatures and the ability to heat larger volumes by improving the distribution of power. With helical antennas, there was 50% SAR at the array center when operated coherently without phase rotation. Three patients were treated with the obturator and a custom-made template using dipole antennas, and temperatures were measured in five obturator catheters. Therapeutic heating was measured in the catheters on the obturator between antennas in contact with the vaginal mucosa. PMID:1572816

Ryan, T P; Taylor, J H; Coughlin, C T

1992-01-01

207

Interstitial microwave hyperthermia and brachytherapy for malignancies of the vulva and vagina. I: Design and testing of a modified intracavitary obturator.  

UK PubMed Central (United Kingdom)

A vaginal obturator was fabricated to be used in combination with implanted catheters to provide microwave hyperthermia and brachytherapy to the vulva and vaginal wall. This site is difficult to heat or irradiate solely with interstitial techniques. The obturator was modified to provide grooves for the mounting of interstitial catheters into the outer wall and was matched with a template for circumferential implants. Power deposition tests were done using arrays of three microwave antenna designs: dipole (hA = hB = 3.9 cm), helical (3.9 cm coil, shorted), and modified dipole (1.0 cm helix on dipole tip) to test the performance of the obturator. The obturator and four non-obturator catheters were positioned in muscle-equivalent phantom. Two obturator catheters along with two free-standing catheters formed the obturator array. Four freestanding catheters formed the non-obturator array. Power deposition or specific absorption rate (SAR) measurements were made along the central axis, bisect, and diagonal transect of each array. SAR results showed that antennas in the obturator wall radiated as dipole theory predicts, although with less power density when compared to antennas in the same catheters spaced 1.8 cm from the obturator. This could be compensated for by increasing the power to the antennas in the obturator by 42%. Adjacent pairs of antennas were placed 90 degrees out of phase for 0.25 sec and rotated around the array. Phase rotation demonstrated that the central array SAR peaks could be lowered from 100% to 50% SAR, with dipole antennas thus resulting in lowered peak temperatures and the ability to heat larger volumes by improving the distribution of power. With helical antennas, there was 50% SAR at the array center when operated coherently without phase rotation. Three patients were treated with the obturator and a custom-made template using dipole antennas, and temperatures were measured in five obturator catheters. Therapeutic heating was measured in the catheters on the obturator between antennas in contact with the vaginal mucosa.

Ryan TP; Taylor JH; Coughlin CT

1992-01-01

208

Carcinoma epidermoide no queratinizante de células grandes y pequeñas en vagina/ Large and small cells non-keratinizing epidermoid vaginal carcinoma  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Se presentan 5 casos clínicos de pacientes atendidas en la consulta de patología de cuello del Hospital Provincial Ginecoobstétrico "Mariana Grajales Coello" de Santiago de Cuba por presentar sangrado vaginal, dolor en bajo vientre, leucorrea y lesiones vaginales. El estudio anatomopatológico confirmó el diagnóstico de carcinoma de células escamosas o epidermoide. Abstract in english Five case reports of patients who were assisted at the cervix Pathology Department from "Mariana Grajales Coello" Provincial Gynecological Obstetrical Hospital in Santiago de Cuba due to vaginal bleeding, low abdominal pain, leukorrhea and vaginal injuries are presented. The pathological study confirmed the diagnosis of squamous or epidermoid cells carcinoma.

Masó Anaya, Ofelia; Morales Larramendi, María Elena; Díaz Pérez, Dolores; Dager Dager, Esperanza; Bolaños Diego, Gloria Adelaida

2012-03-01

209

Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus.  

Science.gov (United States)

The patient was a 57-year-old white woman who presented with a 3.0 x 2.0-cm partially ulcerated vaginal polyp. Histology revealed a malignant mixed mullerian tumor composed of invasive squamous cell carcinoma with deeper areas of undifferentiated pleomorphic sarcoma. Invasive carcinoma had overlying high-grade vaginal intraepithelial neoplasia (VaIN III), which contained koilocytic atypia. In situ hybridization detected high-risk human papillomavirus DNA in both the carcinoma and the sarcoma components. PMID:17640554

Sebenik, Matjaz; Yan, Zhijije; Khalbuss, Walid E; Mittal, Khush

2007-08-01

210

Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus.  

UK PubMed Central (United Kingdom)

The patient was a 57-year-old white woman who presented with a 3.0 x 2.0-cm partially ulcerated vaginal polyp. Histology revealed a malignant mixed mullerian tumor composed of invasive squamous cell carcinoma with deeper areas of undifferentiated pleomorphic sarcoma. Invasive carcinoma had overlying high-grade vaginal intraepithelial neoplasia (VaIN III), which contained koilocytic atypia. In situ hybridization detected high-risk human papillomavirus DNA in both the carcinoma and the sarcoma components.

Sebenik M; Yan Z; Khalbuss WE; Mittal K

2007-08-01

211

Ovarian Cancer  

Medline Plus

Full Text Available ... in front of the vagina and uterus. The kidneys drain the urine into the bladder through 2 ... located above and behind the vagina and uterus. Kidney Bladder Urethra Ureter Cancer and its Causes The ...

212

Ovarian Cancer  

Medline Plus

Full Text Available ... organs include: • The vagina • The uterus • The fallopian tubes • The ovaries. The female reproductive organs are located ... that are needed for reproduction. Vagina Uterus Fallopian Tubes Ovaries The other main function of the ovaries ...

213

Ovarian Cysts  

Medline Plus

Full Text Available ... may be diagnosed and treated. Vagina Uterus Fallopian Tubes Ovaries Anatomy The female reproductive organs include: • the vagina • the uterus • the fallopian tubes • the ovaries The female reproductive organs are located ...

214

Uterine Fibroids  

Medline Plus

Full Text Available ... diagnosis, and treatment options. Anatomy Vagina Uterus Fallopian Tubes Ovaries The female reproductive organs include: • the vagina • the uterus • the fallopian tubes • the ovaries The female reproductive organs are located ...

215

Endometriosis  

Medline Plus

Full Text Available ... and review some treatment options. Vagina Uterus Fallopian Tubes Ovaries Anatomy The female reproductive organs include: • the vagina • the uterus • the fallopian tubes • the ovaries The female reproductive organs are located ...

216

Hysterectomy  

Medline Plus

Full Text Available ... benefits and risks of this surgery. Ovaries Fallopian Tubes Uterus Vagina Anatomy This document is a summary ... The female reproductive organs include: • Vagina • Uterus • Fallopian tubes • And ovaries. These organs are located in the ...

217

Dilation and Curettage  

Medline Plus

Full Text Available ... treated or diagnosed with it. Vagina Uterus Fallopian Tubes Ovaries Anatomy The female reproductive organs include: • the vagina • the uterus • the fallopian tubes • the ovaries The female reproductive organs are located ...

218

Menopause  

Medline Plus

Full Text Available ... female reproductive organs include the: • vagina • uterus • fallopian tubes • ovaries The female reproductive organs are located in ... urinary bladder and the rectum. Vagina Uterus Fallopian Tubes Ovaries The ovaries are glands, with 2 main ...

219

Colposcopy  

Medline Plus

Full Text Available ... possible risks and complications. Anatomy Vagina Uterus Fallopian Tubes Ovaries The female reproductive organs include: • the vagina • the uterus • the Fallopian tubes • the ovaries The female reproductive organs are located ...

220

Pap Smear  

Medline Plus

Full Text Available ... is and why it is beneficial. Ovaries Fallopian Tubes Uterus Vagina Anatomy This document is for informational ... organs include: • The vagina • The uterus • The Fallopian tubes • The ovaries These organs are located in the ...

 
 
 
 
221

FEMALE POSTERIOR WALL PROSTHESIS  

UK PubMed Central (United Kingdom)

A prosthesis comprising a flattened lobe (100), a neck (110) and a handle (120) sized and shaped to shield the posterior vaginal wall from frictional contact during coitus. This self-retaining prosthesis comprises a means to retain the flattened lobe (100) within the vagina and a means to prevent the handle (120) from entering the vagina during insertion of the prosthesis or during coitus. This prosthesis decreases the volume of the vagina and decreases the area of the vaginal opening providing a non-surgical, cost-effective solution to tightening a woman's vagina. The posterior vaginal wall prosthesis enables women who have larger vaginas to use tampons.

MAURETTE NEIL LUKE

222

Preparation of nifuratel and nysfungin vaginal soft capsules  

UK PubMed Central (United Kingdom)

The present invention relates to preparation of a new medicine Nifuratel nysfungin vagina tablet for gynecologic antisepsis and anti-inflammation. Nifuratel nysfungin can play a more complete role in curing mixed vagina infection (candida, trichomonas and bacteria) and pathogen which can not be or can not be timely and clearly diagnosed and preventing mildew secondary infection and recurrence after the treatment of other medicines. The present invention can be used for curing bacterial vaginopathy, trichomonas vaginitis, monilial vulvovaginitis, and vagina mixed infection. The advantage of the present invention lies in that the added pH buffer system ensures pH of the medicine is within 3.5 to 4.0 close to the physiological pH of vagina, thus effectively protecting the physiological environment of vagina, providing the appropriate living conditions beneficial to flora in vagina and promoting the recovery of diseases.

GUODONG LI

223

In vitro activity of nifuratel on vaginal bacteria: could it be a good candidate for the treatment of bacterial vaginosis?  

Science.gov (United States)

Bacterial vaginosis is characterized by a shift of the physiological flora to a diverse spectrum of bacteria, where Gardnerella vaginalis and Atopobium vaginae are the most important markers. In this study, the antimicrobial activity of nifuratel against G. vaginalis, A. vaginae, and lactobacilli was compared with that of the two currently used antibiotics metronidazole and clindamycin. Results suggest that nifuratel has a better spectrum of activity, being highly active against G. vaginalis and A. vaginae without affecting lactobacilli. PMID:21321147

Togni, Giuseppe; Battini, Valeria; Bulgheroni, Anna; Mailland, Federico; Caserini, Maurizio; Mendling, Werner

2011-02-14

224

In Vitro Activity of Nifuratel on Vaginal Bacteria: Could It Be a Good Candidate for the Treatment of Bacterial Vaginosis??  

Science.gov (United States)

Bacterial vaginosis is characterized by a shift of the physiological flora to a diverse spectrum of bacteria, where Gardnerella vaginalis and Atopobium vaginae are the most important markers. In this study, the antimicrobial activity of nifuratel against G. vaginalis, A. vaginae, and lactobacilli was compared with that of the two currently used antibiotics metronidazole and clindamycin. Results suggest that nifuratel has a better spectrum of activity, being highly active against G. vaginalis and A. vaginae without affecting lactobacilli.

Togni, Giuseppe; Battini, Valeria; Bulgheroni, Anna; Mailland, Federico; Caserini, Maurizio; Mendling, Werner

2011-01-01

225

In vitro activity of nifuratel on vaginal bacteria: could it be a good candidate for the treatment of bacterial vaginosis?  

UK PubMed Central (United Kingdom)

Bacterial vaginosis is characterized by a shift of the physiological flora to a diverse spectrum of bacteria, where Gardnerella vaginalis and Atopobium vaginae are the most important markers. In this study, the antimicrobial activity of nifuratel against G. vaginalis, A. vaginae, and lactobacilli was compared with that of the two currently used antibiotics metronidazole and clindamycin. Results suggest that nifuratel has a better spectrum of activity, being highly active against G. vaginalis and A. vaginae without affecting lactobacilli.

Togni G; Battini V; Bulgheroni A; Mailland F; Caserini M; Mendling W

2011-05-01

226

In Vitro Activity of Nifuratel on Vaginal Bacteria: Could It Be a Good Candidate for the Treatment of Bacterial Vaginosis??  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Bacterial vaginosis is characterized by a shift of the physiological flora to a diverse spectrum of bacteria, where Gardnerella vaginalis and Atopobium vaginae are the most important markers. In this study, the antimicrobial activity of nifuratel against G. vaginalis, A. vaginae, and lactobacilli wa...

Togni, Giuseppe; Battini, Valeria; Bulgheroni, Anna; Mailland, Federico; Caserini, Maurizio; Mendling, Werner

227

Vaginal applicator with variable tips  

Energy Technology Data Exchange (ETDEWEB)

A new vaginal applicator with variable tips for intracavitary radiotherapy for cancer of the uterine cervix was devised. Both TAO and Henschke Type can be attached to it. With this applicator, injury of the vagina is avoided and tumor recurrence at the vagina will be reduced. (author).

Kubota, Susumu; Furukawa, Shigeo; Nakamura, Yuzuru (National Inst. of Radiological Sciences, Chiba (Japan)); Sekiya, Toru; Shirakawa, Takako; Endo, Hisashi; Oda, Kurahiro; Akisada, Masayoshi

1991-12-01

228

Vaginal applicator with variable tips  

International Nuclear Information System (INIS)

A new vaginal applicator with variable tips for intracavitary radiotherapy for cancer of the uterine cervix was devised. Both TAO and Henschke Type can be attached to it. With this applicator, injury of the vagina is avoided and tumor recurrence at the vagina will be reduced. (author).

1991-01-01

229

Methods for quantitative and qualitative evaluation of vaginal microflora during menstruation.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The quantitative and qualitative changes in the bacterial flora of the vagina during menstruation have received inadequate study. Similarly, the effect of vaginal tampons on the microbial flora as well as the relationship between the microbial flora of the vagina and that of the tampon has not been ...

Onderdonk, A B; Zamarchi, G R; Walsh, J A; Mellor, R D; Muñoz, A; Kass, E H

230

FEMALE POSTERIOR WALL PROSTHESIS  

UK PubMed Central (United Kingdom)

A prosthesis comprising a pancake-shaped body (100), a neck (110) and a flared flattened handle (120) sized and shaped to shield the posterior vaginal wall (610) from frictional contact during coitus. This self-retaining prosthesis comprises a means to retain the pancake-shaped body (100) within the vagina and a means to prevent the flared flattened handle (120) from entering the vagina during insertion of the prosthesis or during coitus. This prosthesis decreases the volume of the vagina and decreases the area of the vaginal opening providing a non-surgical, cost-effective solution to tightening a woman's vagina. The posterior vaginal wall prosthesis enables women who have larger vaginas to use tampons.

MAURETTE NEIL L

231

FEMALE POSTERIOR WALL PROSTHESIS  

UK PubMed Central (United Kingdom)

A prosthesis comprising a pancake-shaped body (100), a neck (110) and a flared flattened handle (120) sized and shaped to shield the posterior vaginal wall (610) from frictional contact during coitus. This self-retaining prosthesis comprises a means to retain the pancake-shaped body (100) within the vagina and a means to prevent the flared flattened handle (120) from entering the vagina during insertion of the prosthesis or during coitus. This prosthesis decreases the volume of the vagina and decreases the area of the vaginal opening providing a non-surgical, cost-effective solution to tightening a woman's vagina. The posterior vaginal wall prosthesis enables women who have larger vaginas to use tampons

MAURETTE NEIL L

232

Nifuratel-nystatin vaginal effervescent-tablets  

UK PubMed Central (United Kingdom)

The invention relates to a nifungin-canstat vagina effervescent tablet. Wherein, it uses nifungin and canstat, with acid-alkali adding system, and stuff or directly being compressed into tablet or particles then to be compressed into tablet, or uses macrogol to cover the alkali, then to be compressed into tablet. The invention uses the acid alkali system which will generate carbon dioxide gas when meeting water as slaking agent therefore, the tablet will foam and slake when adsorbs water in vagina, to disperse the elements into vagina completely, as uterine cervix, etc.

ZHANG TONGLI YU

233

Fulicin regulates the female reproductive organs of the snail, Achatina fulica.  

UK PubMed Central (United Kingdom)

Fulicin is a D-amino acid-containing neuropeptide that has been thought to control male copulatory behavior in the land snail, Achatina fulica. In the present study, we demonstrated that the vagina and the oviduct of Achatina were densely innervated by fulicin-like immunoreactive neuronal fibers. We confirmed that fulicin was actually present in the vagina by mass spectrometry. Furthermore, fulicin showed a profound excitatory effect on contractions of the vagina and the oviduct. These results suggest that fulicin controls female egg-laying behavior as an excitatory neuropeptide regulating the female reproductive organs of the snail.

Fujisawa Y; Masuda K; Minakata H

2000-08-01

234

Intraperitoneal leech: A rare complication of leech bite  

Digital Repository Infrastructure Vision for European Research (DRIVER)

An intraperitoneal leech, which entered through vagina and uterus in a 2-year-old girl is reported. The child presented with intraperitoneal hemorrhage and shock. A leech inside the peritoneal cavity has never been reported in the literature.

Saha, Manoj; Nagi, Sedengulie

235

Intraperitoneal leech: A rare complication of leech bite.  

UK PubMed Central (United Kingdom)

An intraperitoneal leech, which entered through vagina and uterus in a 2-year-old girl is reported. The child presented with intraperitoneal hemorrhage and shock. A leech inside the peritoneal cavity has never been reported in the literature.

Saha M; Nagi S

2011-10-01

236

Crohn's Disease  

Medline Plus

Full Text Available ... a blood relative with an inflammatory bowel disease. Men and women are affected equally. Crohn's disease affects ... or stools may seep from the vagina. For men AND women with fistulae connecting the intestines to ...

237

Cervicitis  

Science.gov (United States)

... Avoid chemical irritants such as douches and deodorant tampons. Make sure that any foreign objects you insert into your vagina (such as tampons) are placed properly. Be sure to follow instructions ...

238

Dilation and Curettage  

Medline Plus

Full Text Available ... diseases that can be treated or diagnosed with it. Vagina Uterus Fallopian Tubes Ovaries Anatomy The female ... woman becomes pregnant. When an egg is released, it goes down the fallopian tube, where it may ...

239

Uterine Fibroids  

Medline Plus

Full Text Available ... and their causes, symptoms, diagnosis, and treatment options. Anatomy Vagina Uterus Fallopian Tubes Ovaries The female reproductive ... magnetic resonance imaging (MRI) machine to visualize patient anatomy, map the volume of fibroid tissue to be ...

240

Intestinal Infarctus following Dilatation and Uterine Curettage.  

UK PubMed Central (United Kingdom)

We present a case of intestinal infarctus through the vagina. This was a consequence of induced abortion done clandestinely. The main objective was to point out the surgical complications of uterine dilatation and curettage by means of this rare case.

Ngowe NM; Atangana R; Eyenga VC; Sosso MA

2008-01-01

 
 
 
 
241

Vaginal Birth  

Medline Plus

Full Text Available ... vagina. When this happens, we say the mother’s “water broke.” Labor should start if the water breaks. If labor does not start after the water breaks, a doctor should be notified. The doctor ...

242

Laparoscopic Supracervical Hysterectomy  

Medline Plus

Full Text Available ... The cervix is the little organ at the end of the uterus which attaches to the vagina ... insert in the umbilicus and that's where we end up inside the patient's abdomen, which is…I ...

243

Sertaconazole antibacterial effervescing agent, preparation method and application thereof  

UK PubMed Central (United Kingdom)

Sertaconazole antibacterial effervescing agent belongs to the technical field of gynecology preparation, comprising constituents as follows: sertaconazole of one part by weight, PH system disintegrant of 4-5 parts by weight, and fillings of 0.02-0.15 parts by weight. Preparation technique of the sertaconazole antibacterial effervescing agent is simple, which regards sertaconazole as the main parent drug to prepare effervescing agent the effervescing agent is placed in vagina to fully pervade the whole vagina after dimension increment, thereby making vagina plica and vagina nest fully contact the medicine accordingly, this invention overcomes disadvantages of other agents that it is slow in prographarm, low in therapeutic effect and easy for drug depletion in addition, this invention is convenient for utilization and higher in biological utilization rate of medicine.

PENG ZHOU; YOUGONG DU; WEIWEI HUANG

244

Amniocentesis  

Medline Plus

Full Text Available ... It is not available in many places. A sample of placenta tissue is taken through the vagina ... risk of limb deformity. Results After amniocentesis, the sample of amniotic fluid is sent to a lab ...

245

Robotic-Assisted Hysterectomy  

Medline Plus

Full Text Available ... that the arms of the robotic instruments, these edges, they rotate in multiple degrees of freedom. In ... uterus, is you can see this is the edge of the vagina right here anteriorly. This is ...

246

Disorders of the Vulva  

Science.gov (United States)

... atrophy? • How is vulvar atrophy treated? • What is vulvar intraepithelial neoplasia (VIN)? • What are the signs and symptoms of ... skin or inserted into the vagina. What is vulvar intraepithelial neoplasia (VIN)? Vulvar intraepithelial neoplasia (VIN) is the presence ...

247

Dilation and Curettage  

Medline Plus

Full Text Available ... The female reproductive organs are located in the pelvis, between the urinary bladder and the rectum. The ... These include: • Infection, in the vagina, uterus, or pelvis. • Bleeding, either during or after the operation. Other ...

248

Dilation and Curettage  

Medline Plus

Full Text Available ... And Curettage Reference Summary Introduction Dilation and curettage, or D&C, is a procedure that is used ... and the possible diseases that can be treated or diagnosed with it. Vagina Uterus Fallopian Tubes Ovaries ...

249

Sexually Transmitted Diseases  

Medline Plus

Full Text Available ... painless bumps in the vaginal area, on the penis, or around the anus. If untreated, the warts ... of gonorrhea are: • Discharge from the vagina or penis This document is for informational purposes and is ...

250

Menopause  

Medline Plus

Full Text Available ... of heart attacks, strokes and blood clots in the lungs and legs. The Vagina Body tissue in the ... Heart diseases 2. Strokes 3. Blood clot in the lungs and legs, and 4. Breast cancer This same ...

251

Malformations in a cohort of 284 women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH)  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background The aim of this retrospective study was to describe the spectrum of genital and associated malformations in women with Mayer-Rokitansky-Küster-Hauser syndrome using evaluated diagnostic procedures and the Vagina Cervix Uterus Adnex – associated Malformation class...

Oppelt Patricia G; Lermann Johannes; Strick Reiner; Dittrich Ralf; Strissel Pamela; Rettig Ingo; Schulze Christine

252

Recurrent microdeletion at 17q12 as a cause of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome: two case reports  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH) consists of congenital aplasia of the uterus and the upper part of vagina due to anomalous development of Müllerian ducts, either isolated or associated with other congenital malformations, including renal, skeletal,...

Bernardini Laura; Gimelli Stefania; Gervasini Cristina; Carella Massimo; Baban Anwar; Frontino Giada; Barbano Giancarlo

253

Endometriosis  

Medline Plus

Full Text Available ... in front of the vagina and uterus. The kidneys drain urine into the bladder through 2 tubes ... sure that other diseases, such as infections or kidney problems, are not the reason for the symptoms. ...

254

Hysterectomy  

Medline Plus

Full Text Available ... in front of the vagina and uterus. The kidneys drain the urine into the bladder through 2 ... is very rare for the tubes connecting the kidneys to the bladder, as well as the bladder ...

255

Robotic-Assisted Laparoscopic Sacrocolpopexy for Vaginal Vault Prolapse  

Medline Plus

Full Text Available ... or reattaching the vagina to the bladder, or am I completely off target?" And I think sometimes ... in the right hand. Yes. I use an AMS Y-mesh. I've already trimmed that. If ...

256

Sexually Transmitted Diseases  

Medline Plus

Full Text Available ... about your partner’s sexual history. The following are 7 tips that can help prevent STDs: 1. Correctly ... vagina and increases the risk of getting STDs. 7. Avoid anal intercourse. If it is preferred, use ...

257

Women's Health: Prevent the Top Threats  

Science.gov (United States)

... how-to guide for women Health issues for lesbians: Prevention first see all in Women's health Breast ... how-to guide for women Health issues for lesbians: Prevention first Vagina: What's normal, what's not Cosmetic ...

258

[A woman with a remarkable prolapse].  

Science.gov (United States)

A 59-year-old woman (para 3) felt something protruding from the vagina after a violent cough, followed by an extreme abdominal pain. A spontaneous small bowel evisceration through a vaginal herniation was diagnosed. PMID:23328010

Zelis, Maartje; Mercelina-Roumans, Patricia; Meesters, Berry

2013-01-01

259

21 CFR 884.5330 - Female condom.  

Science.gov (United States)

...A female condom is a sheath-like device that lines the vaginal wall and is inserted into the vagina prior to the initiation of coitus. It is indicated for contraceptive and prophylactic (preventing the transmission of sexually transmitted diseases)...

2013-04-01

260

75 FR 52294 - Effective Date of Requirement for Premarket Approval for Four Class III Preamendments Devices  

Science.gov (United States)

...female condom is a sheath-like device that lines the vaginal wall and is inserted into the vagina prior to the initiation of coitus. It is indicated for contraceptive and prophylactic (preventing the transmission of sexually transmitted diseases...

2010-08-25

 
 
 
 
261

Candidiasis (Thrush)  

Science.gov (United States)

... 15, 2013 Select a Language: Fact Sheet 501 Candidiasis (Thrush) WHAT IS THRUSH? CAN IT BE PREVENTED? ... chelitis. In the vagina, the infection is called yeast infection or vaginitis . This is a common vaginal infection. ...

262

Robotic-Assisted Laparoscopic Sacrocolpopexy for Vaginal Vault Prolapse  

Medline Plus

Full Text Available ... the art procedure to surgically correct vaginal vault prolapse by resupporting the vagina to the sacrum using ... Just to give a little perspective, pelvic organ prolapse is a significant problem in the United States, ...

263

HIV and AIDS  

Medline Plus

Full Text Available ... infection. Infections caused by fungi include: • Candidiasis • Cryptococcal meningitis Candidiasis is a common infection. It causes a ... of the mouth, tongue, esophagus or vagina. Cryptococcal meningitis causes inflammation of the membranes and fluid around ...

264

Screening for Cervical Cancer  

Science.gov (United States)

... Task Force FINAL | 1 Understanding Task Force Recommendations Screening for Cervical Cancer The U.S. Preventive Services Task ... It connects a woman’s uterus to her vagina. Screening for Cervical Cancer In 2010, about 12,000 ...

265

Fístula vesicovaginal continente/ Continent vesicovaginal fistula  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A fístula vesicovaginal é uma comunicação anormal entre a bexiga e a vagina, sendo o tipo mais comum de fístula do trato urinário. A causa mais frequente no Brasil é a iatrogênica, secundária à histerectomia. Classicamente, as mulheres nessa condição, apresentam perda urinária contínua pela vagina e ausência de micção, com forte impacto negativo na qualidade de vida. Apresentamos um caso de fístula vesicovaginal totalmente continente, com seguimento de 11 anos, sem complicações. Abstract in english Vesicovaginal fistula is an abnormal communication between the bladder and vagina and represents the most frequent type of fistula in the urinary tract. The most common cause in Brazil is iatrogenic fistula, secondary to histerectomia. Classically these women present continuous urinary leakage from the vagina and absence of micturition, with strong negative impact on their quality of life. We present a case of totally continent vesicovaginal fistula, with a follow-up of 11 years with no complications.

Toledo, Luís Gustavo Morato de; Santos, Victor Espinheira; Maron, Paulo Eduardo Gourlat; Vedovato, Bruno César; Fucs, Moacyr; Perez, Marjo Deninson Cardenuto

2013-03-01

266

Microflora of urogenital tract in pregnancy with asymptomatic bacterium  

International Nuclear Information System (INIS)

The article contains results of research interrelationship from colonization of vagina and urinary tract diseases. E.coli one of the main factors in development asymptomatic bacterium. Presented high effects of penicillin medicaments and nitrofurans in treatment of asymptomatic bacterium

2006-01-01

267

Procedure for the Purification of Rabbit Sperm Cells and the Separation of Sperm Heads and Tails.  

Science.gov (United States)

Sperm cells collected from mammals by electroejaculation or with an artificial vagina are contaminated by secretions and fluids from the accessory glands, cell debris, and particulate matter such as prostatic vesicular bodies. Seminal plasma is commonly r...

J. C. Laing R. J. Young

1988-01-01

268

Robot-Assisted Gynecologic Surgery  

Medline Plus

Full Text Available ... inside the uterine cavity, and then, that green cap wraps around the cervix, and so, it goes ... the vagina. So now, we use t hat cap while we are dissecting from above as a ...

269

Menopause  

Medline Plus

Full Text Available ... In fact, heart disease kills more women than lung or breast cancer. The following tips will help ... heart attacks, strokes and blood clots in the lungs and legs. The Vagina Body tissue in the ...

270

HIV and AIDS  

Medline Plus

Full Text Available ... causes a thick, white coating on the mucous membranes of the mouth, tongue, esophagus or vagina. Cryptococcal meningitis causes inflammation of the membranes and fluid around the brain and spinal cord. ...

271

Crohn's Disease  

Medline Plus

Full Text Available ... surrounding tissues such as the bladder, vagina, or skin. These tunnels, called fistulae, often become infected. Usually ... Other problems associated with Crohn's Disease include: • arthritis • skin problems such as rashes and sores • inflammation in ...

272

Ovarian Cancer  

Medline Plus

Full Text Available Ovarian Cancer Introduction Ovarian cancer is fairly rare. Ovarian cancer usually occurs in women who are over 50 years ... the vagina and uterus. Kidney Bladder Urethra Ureter Cancer and its Causes The body is made up ...

273

Hysterectomy  

Medline Plus

Full Text Available ... surgery. Ovaries Fallopian Tubes Uterus Vagina Anatomy This document is a summary of what appears on screen ... the release of eggs, needed for reproduction. This document is a summary of what appears on screen ...

274

Robotic-Assisted Laparoscopic Sacrocolpopexy for Vaginal Vault Prolapse  

Medline Plus

Full Text Available ... just irrigate a little bit -- or just suction, no irrigation. Thanks. 00:04:40 What we're ... in there, I mean this is -- there was no mesh attached to the -- to the vagina at ...

275

Vaginal Anomalies: Cloacal Anomalies  

Science.gov (United States)

... to stabilize the newborn, which may require a colostomy , which permits the child to pass stools through ... the front of the vagina. colon: Large intestine. colostomy: An opening, surgically created in the abdomen, that ...

276

Clotrimazole  

Science.gov (United States)

Clotrimazole is used to treat yeast infections of the vagina, mouth, and skin such as athlete's foot, ... Clotrimazole comes as a cream, lotion, powder, and solution to apply to the skin; lozenges (called troches) ...

277

Menopause  

Medline Plus

Full Text Available ... organs are located in the pelvis, between the urinary bladder and the rectum. Vagina Uterus Fallopian Tubes ... you get older, you may begin to have urinary tract problems, such as incontinence. Urge incontinence is ...

278

[Clinical evaluation of an immunological test for premature rupture of the fetal membranes (ROM check test)  

UK PubMed Central (United Kingdom)

Commonly used methods for detecting amniotic fluid in the vagina include research LA cells, ferning, nitrazina paper, ultrasound and dye injection. These methods are difficult to interpret or invasive. We have tested a new method which detects a fetal isoform of fibronectin in vaginal secretion when amniotic fluid is present. Clinical trials demonstrate the sufficient reliability in detecting amniotic fluid in the vagina of women with rupture of amniotic membranes.

Mossa B; Marziani R; Galeano C; Magnanti G; Domenici R

1992-09-01

279

Cervical Squamous Cell Carcinoma and Adenocarcinoma  

Science.gov (United States)

Cervical cancer is a disease in which cancer develops in the tissues of the cervix. The Cancer Genome Atlas is studying the two main types of cervical cancer. Squamous cell carcinoma develops in the thin, flat, squamous cells that line the vagina. Adenocarcinoma arises in the glandular cells in the vagina that secrete mucus. Risk factors for cervical cancer include smoking and human papillomavirus (HPV) infection. In the future, the HPV vaccine will lower the infection rate.

280

Continent vesicovaginal fistula.  

UK PubMed Central (United Kingdom)

Vesicovaginal fistula is an abnormal communication between the bladder and vagina and represents the most frequent type of fistula in the urinary tract. The most common cause in Brazil is iatrogenic fistula, secondary to histerectomia. Classically these women present continuous urinary leakage from the vagina and absence of micturition, with strong negative impact on their quality of life. We present a case of totally continent vesicovaginal fistula, with a follow-up of 11 years with no complications.

Toledo LG; Santos VE; Maron PE; Vedovato BC; Fucs M; Perez MD

2013-03-01

 
 
 
 
281

Radiation therapy of primary vaginal carcinoma.  

UK PubMed Central (United Kingdom)

Primary carcinoma of the vagina is rare, constituting only 1 to 2% of all neoplasms arising in the female genital tract. From 1950-1974, 36 patients with carcinoma of the vagina were treated with radiation at Memorial Sloan-Kettering Cancer Center (MSKCC); 35 (96%) had epidermoid carcinoma and one patient (4%) had adenocarcinoma. These patients were staged according to FIGO. Fourteen patients (39%) were Stage I; six patients (17%) were Stage II; three patients (8%) were Stage III; and 13 patients (36%) were Stage IV. Nine patients (25%) were treated with external radiation and interstitial implant; seven patients (20%) were treated with interstitial implant alone; nine patients (25%) were treated with external radiation alone and 11 patients (30%) with external radiation and intracavitary radiation. The five year NED survival was 71% in Stage I, 66% in Stage II, 33% in Stage III and 0% in Stage IV. This paper discusses radiotherapy management of primary carcinoma of the vagina.

Nori D; Hilaris BS; Stanimir G; Lewis JL Jr

1983-10-01

282

Anatomia e histologia do conduto genital feminino de Pomacea canaliculata (Lamarck, 1822) (Mollusca, Gastropoda, Pilidae)  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english In this paper the authors give an anatomical and histological analysis of the genital duct in mature and immature females of Pomacea canaliculata (Lamarck, 1822). Anatomically, the vagina has an equal dimension in its extension, varying in form and volume, according to the maturation period. In the immaturity, it has a smaller diameter and volume. In the maturity, the vagina increases in volume, having the aspect of a tumescent organ, and in certain specimens shows an alb (more) uminous pink thread in its lumen. Histologically, the calcigenic activity of the gland is evidentiated by the presence of an amorphous and basophilic mass, without nuclear material. This material has a fragmented aspect in the vagina lumen that reacts positively in van Kossa's coloured preparations for calcareous salts.

Mesquita, Eliana de Fátima Marques de; Coelho, Arnaldo Campos dos Santos; Santos, Jefferson Andrade dos

1990-01-01

283

Anatomia e histologia do conduto genital feminino de Pomacea canaliculata (Lamarck, 1822) (Mollusca, Gastropoda, Pilidae)  

Directory of Open Access Journals (Sweden)

Full Text Available In this paper the authors give an anatomical and histological analysis of the genital duct in mature and immature females of Pomacea canaliculata (Lamarck, 1822). Anatomically, the vagina has an equal dimension in its extension, varying in form and volume, according to the maturation period. In the immaturity, it has a smaller diameter and volume. In the maturity, the vagina increases in volume, having the aspect of a tumescent organ, and in certain specimens shows an albuminous pink thread in its lumen. Histologically, the calcigenic activity of the gland is evidentiated by the presence of an amorphous and basophilic mass, without nuclear material. This material has a fragmented aspect in the vagina lumen that reacts positively in van Kossa's coloured preparations for calcareous salts.

Eliana de Fátima Marques de Mesquita; Arnaldo Campos dos Santos Coelho; Jefferson Andrade dos Santos

1990-01-01

284

The impact of radiotherapy for carcinoma of the cervix on sexual function assessed using the LENT SOMA scales  

International Nuclear Information System (INIS)

Background and purpose: As there are few studies examining the impact of radiotherapy on sexuality, we assessed the effect of radiotherapy for carcinoma of the cervix on sexual health and the ability of the LENT system to assess sexual function. Materials and methods: Using the vagina and sexual dysfunction scales of the LENT SOMA scales, subjective scores were measured prospectively before initiation of radiotherapy for 89 women, and at the following times after the start of treatment: 21, 70, 200, 400, 600 and 800 days. Results: There was considerable variation in pre-radiotherapy scores that was not related to disease stage (P=0.054), but was related to patient age (P=0.037, for the average vagina scores and P=0.039 for the maximum vagina scores) The scores were influenced by prior surgery (P

2003-01-01

285

INCONTINENCE TREATMENT DEVICE  

UK PubMed Central (United Kingdom)

An incontinence treatment apparatus is provided to prevent generation of bacteria in the vagina and uterus by removing foreign elements of the vagina, and to promote contraction of the vagina and prevention of incontinence by a pelvic floor muscle strengthening exercise. An incontinence treatment apparatus includes: an oval-shaped body(100) made of silver of 99.9 % purity, and having a connection ring(101) formed on the rear a pure gold bead(102) continuously connected to the connection ring of the body, and made of gold of 99.9 % purity and a pull string(110) comprising plural rings(110a) made of silver of 99.9 % purity, and continuously connected to the pure gold bead.

KIM GWANG SOON

286

Sobre uma nova espécie do gênero Acanthocolpus Lühe, 1906 On a new specie under Acanthocolpus Lühe, 1906  

Directory of Open Access Journals (Sweden)

Full Text Available Os autores, na presente nota, propõem Acanthocolpus brasiliensis sp. n. sendo este gênero pela primeira vez referido no Brasil. A espécie aqui descrita difere das demais do gênero pela ausência de espinhos na vagina e no ducto hermafrodita e pela presença de vitelinos em quase toda extensão da metade posterior do corpo.In this paper the authors propose a new specie under Acanthocolpus Lühe, 1906 also reafirms this genus for the first time in Brasil. Acanthocolpus brasiliensis sp. n. differs from the other species of the genus by presenting folicular vitellaria in almost the hole area of the posterior part of the body, by the absence of spines in vagina and in ejaculatory duct. A. brasiliensis sp. n. is similar to A. orientalis Srivastava, 1939, which differs also by the size of the body, cirrus sac and vagina.

Berenice M. M. Fernandes; Santiago V. de Souza

1973-01-01

287

Sobre uma nova espécie do gênero Acanthocolpus Lühe, 1906/ On a new specie under Acanthocolpus Lühe, 1906  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Os autores, na presente nota, propõem Acanthocolpus brasiliensis sp. n. sendo este gênero pela primeira vez referido no Brasil. A espécie aqui descrita difere das demais do gênero pela ausência de espinhos na vagina e no ducto hermafrodita e pela presença de vitelinos em quase toda extensão da metade posterior do corpo. Abstract in english In this paper the authors propose a new specie under Acanthocolpus Lühe, 1906 also reafirms this genus for the first time in Brasil. Acanthocolpus brasiliensis sp. n. differs from the other species of the genus by presenting folicular vitellaria in almost the hole area of the posterior part of the body, by the absence of spines in vagina and in ejaculatory duct. A. brasiliensis sp. n. is similar to A. orientalis Srivastava, 1939, which differs also by the size of the body, cirrus sac and vagina.

Fernandes, Berenice M. M.; Souza, Santiago V. de

1973-01-01

288

A new species of Sciadiocara Skrjabin, 1916 (Nematoda: Acuariidae) parasitic in shorebirds in Argentina.  

UK PubMed Central (United Kingdom)

In the present paper we describe a new species of the genus Sciadiocara from Haematopus palliatus from the Mar Chiquita coastal lagoon (37 degrees 46' S, 57 degrees 27' W), Argentina. We provide two host records (H. palliatus and Larus dominicanus) for the genus, both from Buenos Aires province, Argentina. S. haematopodi n. sp. closely resembles S. legendrei Petter, 1967. The new species can be distinguished by the morphology of the distal end of the left spicule, the shorter length of the right spicule, the number of pre-anal papillae and the ratio of the length of the vagina vera to the length of the vagina uterina.

Cremonte F; Navone GT; Etchegoin JA

1999-03-01

289

A new species of Sciadiocara Skrjabin, 1916 (Nematoda: Acuariidae) parasitic in shorebirds in Argentina.  

Science.gov (United States)

In the present paper we describe a new species of the genus Sciadiocara from Haematopus palliatus from the Mar Chiquita coastal lagoon (37 degrees 46' S, 57 degrees 27' W), Argentina. We provide two host records (H. palliatus and Larus dominicanus) for the genus, both from Buenos Aires province, Argentina. S. haematopodi n. sp. closely resembles S. legendrei Petter, 1967. The new species can be distinguished by the morphology of the distal end of the left spicule, the shorter length of the right spicule, the number of pre-anal papillae and the ratio of the length of the vagina vera to the length of the vagina uterina. PMID:10613539

Cremonte, F; Navone, G T; Etchegoin, J A

1999-03-01

290

[Cytology and histology of vaginal leiomyosarcoma: a rare tumor (author's transl)  

UK PubMed Central (United Kingdom)

Leiomyosarcomas as primary tumors are usually found in the corpus uteri or the cervix, they are extremely rare in the vagina. Case report of a 45 yr old woman with primary Leiomyosarcoma of the vagina. The cytological diagnosis was difficult, as a differentiation between Leiomyosarcoma, Melanoma and mesodermal mixed-tumor by means of cytology is not univocal. The histological diagnosis is certain. The tumor is demonstrated in its many histological and cytological aspects. The reaction to radiation is poor. Prognosis depends upon time of diagnosis and treatment and is usually unfavorable.

Herting W; Feichter GE; Fischer WM

1976-11-01

291

Scientific Rationale and Algorithmization of Sochi Resort Natural and Preformed Physical Therapeutic Factors in the Course of Combined Treatment of Patients with Chronic Vulvovaginitis  

Directory of Open Access Journals (Sweden)

Full Text Available Chronic vulvovaginitis is the most wide-spread gynecological pathology among women of childbearing age. The chief causations of nonspecific vulvovaginitis are reduction in oestrogen, disturbances in vaginal acidity, intestine dysbacteriosis, local and general immune disturbances. The growth of vagina opportunistic pathogenic flora is closely connected with the increase of bacterial slimes on vagina mucus. Sulphur balneotherapy in the form of general baths and vaginal irrigations, mechanical physiotherapy promotes disruption of bacterial slimes, oestrogen elevation, immune reconstruction and vaginal biocenosis, which has positive effect on patients’ fertility level, frequency of obstetrical and perinatal pathologies.

Kirill V. Gordon; Evgenii F. Filippov; Svetlana M. Avtomeenko

2012-01-01

292

Colonization of human genital tract by Streptococcus agalactiae.  

UK PubMed Central (United Kingdom)

This bacteriological study involved 92 young married couples who required medical help because of infertility. Colonization of male urethra or the presence of Streptococcus agalactiae in the ejaculate was detected in 9.78% of men. Vagina or vagina and cervix were colonized in 4.35% of women. Oral application of phenoxymethylpenicillin temporarily eliminated S. agalactiae from the genital tract of all colonized partners. Repeated colonization occurred 3-7 months later, in three cases by different serotypes compared with pretreatment period, in one case by the same serotype.

Stropnik Z; Res P; Brglez I

1987-10-01

293

Colonization of human genital tract by Streptococcus agalactiae.  

Science.gov (United States)

This bacteriological study involved 92 young married couples who required medical help because of infertility. Colonization of male urethra or the presence of Streptococcus agalactiae in the ejaculate was detected in 9.78% of men. Vagina or vagina and cervix were colonized in 4.35% of women. Oral application of phenoxymethylpenicillin temporarily eliminated S. agalactiae from the genital tract of all colonized partners. Repeated colonization occurred 3-7 months later, in three cases by different serotypes compared with pretreatment period, in one case by the same serotype. PMID:3125707

Stropnik, Z; Res, P; Brglez, I

1987-10-01

294

Vaginal vault rupture with evisceration of small intestine during coitus.  

UK PubMed Central (United Kingdom)

In 2009, a 41-year-old Thai woman who had undergone abdominal hysterectomy 4 months earlier was admitted because of bleeding per vagina without pain during coitus for 1 day. She had undergone pelvic examination that disclosed small intestine in vagina and scanty bleeding of vaginal vault. Closure of the rupture of the vaginal vault during laparotomy was completed, resulting in satisfactory condition. Vaginal vault rupture is a rare condition. Prompt surgical and medical intervention are required to prevent complications. Incidence, risk factors, and management for rupture of the vaginal vault that occurs after total abdominal hysterectomy are discussed.

Nopdonrattakoon L

2010-02-01

295

Clear Cell Carcinoma Presented as a Large Polypoid Mass Expanding the Vaginal Fornix: Report of Two Cases  

International Nuclear Information System (INIS)

Primary clear cell carcinoma of the vagina or uterine cervix is a very rare tumor. We report radiologic findings of two cases of clear cell carcinoma, arising in the vagina and uterine cervix in a 16-year-old and a 26-year-old female. These were presented as a large polypoid mass with a stalk and expanding the vaginal fornix. One case with ultrasonography showed relatively homogeneous echoic solid mass; the other case with a CT showed heterogeneously and strongly enhancing mass. All of the two cases showed non-specific signal intensity with heterogeneous and strong enhancement on MRI.

2012-01-01

296

Didelphic uterus and obstructed hemivagina with ipsilateral renal agenesis: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Mullerian anomalies comprise a broad range of anomalies. The clinical syndrome of a double uterus, double cervix with obstruction of the vagina and ipsilateral renal agenesis is rare and a high index of suspicion is necessary to diagnose this disorder. The authors report a case of a 13-year-old girl with progressive abdominal pain during menses seven months after menarche. Magnetic resonance showed a didelphic uterus, right hemihaematometrocolpos and suggested the presence of two vaginas. The patient underwent transvaginal excision of the septum with prompt clinical improvement.

Rita Abreu

297

Síndrome de Morris Morris Syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available Introducción: el síndrome de resistencia completa a los andrógenos, feminización testicular o síndrome de Morris, puede presentarse en uno de cada 20 000 a 64 000 recién nacidos varones. Objetivo: presentar un caso con genotipo masculino y fenotipo femenino dado por desarrollo mamario, con genitales externos femeninos con hipoplasia de los labios mayores y menores y la vagina muy corta que termina en un fondo de saco ciego. Métodos: se valora en la consulta a una paciente adolescente de 19 años de edad con amenorrea primaria y contacto sexual insatisfactorio (imposibilidad de penetración). Resultados: se comprueba al examen vagina rudimentaria de unos dos centímetros y escaso desarrollo de genitales externos. En los exámenes complementarios se comprueban cifras de testosterona y LH aumentadas, así como el estradiol disminuido y un cariotipo 46 XY por lo que se sospecha síndrome de Morris y se planifica intervención quirúrgica combinada en un tiempo (vaginal y abdominal) donde se realiza anexectomía total derecha por video laparoscopia y reconstrucción de vagina por técnica de Williams. Posoperatorio satisfactorio y seguimiento ulterior por consulta donde se comprueba vagina funcional y estabilidad emocional de la paciente. Conclusiones: el estudio anatomo-patológico comprueba la existencia de ovario y testículo en la muestra quirúrgica lo que confirma el diagnóstico de síndrome de Morris o de resistencia completa a los andrógenos.Introduction:the syndrome of complete androgen resistance, testicular feminization or Morris syndrome may occur in one in 20 000 to 64 000 of male newborns. Objective: to present a case with male genotype and female phenotype given by breast development, female external genitalia with hypoplasia of the labia and very short vagina ending in a blind pouch Methods: a 19 year- old female patient is assisted in consultation due primary amenorrhea and unsatisfactory sexual contact (impossibility of penetration). Results: at examination, we found a rudimentary vagina of about two inches and underdeveloped external genitalia. The exams confirmed increased LH and testosterone levels and decreased estradiol. It is also found a 46 XY karyotype, so Morris syndrome is suspected. Combined surgery is planned for the vagina and abdomen. Total videolaparoscopy right adnexectomy and vaginal reconstruction by technique of Williams are performed. We had satisfactory postoperative and subsequent follow-up consultation where functional vagina and emotional stability of the patient were checked. Conclusions: the pathological study verifies the existence of ovary and testis in the surgical specimen confirming the diagnosis of Morris syndrome or complete androgen resistance.

Julio Aurelio Borrego López; Joel Alejandro Varona Sánchez; Georgina Areces Delgado; Luis Ernesto Formoso Martín

2012-01-01

298

Síndrome de Morris/ Morris Syndrome  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Introducción: el síndrome de resistencia completa a los andrógenos, feminización testicular o síndrome de Morris, puede presentarse en uno de cada 20 000 a 64 000 recién nacidos varones. Objetivo: presentar un caso con genotipo masculino y fenotipo femenino dado por desarrollo mamario, con genitales externos femeninos con hipoplasia de los labios mayores y menores y la vagina muy corta que termina en un fondo de saco ciego. Métodos: se valora en la consulta a una p (more) aciente adolescente de 19 años de edad con amenorrea primaria y contacto sexual insatisfactorio (imposibilidad de penetración). Resultados: se comprueba al examen vagina rudimentaria de unos dos centímetros y escaso desarrollo de genitales externos. En los exámenes complementarios se comprueban cifras de testosterona y LH aumentadas, así como el estradiol disminuido y un cariotipo 46 XY por lo que se sospecha síndrome de Morris y se planifica intervención quirúrgica combinada en un tiempo (vaginal y abdominal) donde se realiza anexectomía total derecha por video laparoscopia y reconstrucción de vagina por técnica de Williams. Posoperatorio satisfactorio y seguimiento ulterior por consulta donde se comprueba vagina funcional y estabilidad emocional de la paciente. Conclusiones: el estudio anatomo-patológico comprueba la existencia de ovario y testículo en la muestra quirúrgica lo que confirma el diagnóstico de síndrome de Morris o de resistencia completa a los andrógenos. Abstract in english Introduction:the syndrome of complete androgen resistance, testicular feminization or Morris syndrome may occur in one in 20 000 to 64 000 of male newborns. Objective: to present a case with male genotype and female phenotype given by breast development, female external genitalia with hypoplasia of the labia and very short vagina ending in a blind pouch Methods: a 19 year- old female patient is assisted in consultation due primary amenorrhea and unsatisfactory sexual cont (more) act (impossibility of penetration). Results: at examination, we found a rudimentary vagina of about two inches and underdeveloped external genitalia. The exams confirmed increased LH and testosterone levels and decreased estradiol. It is also found a 46 XY karyotype, so Morris syndrome is suspected. Combined surgery is planned for the vagina and abdomen. Total videolaparoscopy right adnexectomy and vaginal reconstruction by technique of Williams are performed. We had satisfactory postoperative and subsequent follow-up consultation where functional vagina and emotional stability of the patient were checked. Conclusions: the pathological study verifies the existence of ovary and testis in the surgical specimen confirming the diagnosis of Morris syndrome or complete androgen resistance.

Borrego López, Julio Aurelio; Varona Sánchez, Joel Alejandro; Areces Delgado, Georgina; Formoso Martín, Luis Ernesto

2012-09-01

299

Mesoscopic study on the bulbus venae jugularis superior.  

Science.gov (United States)

Mesoscopic observations on the bulbus venae jugularis superior showed that the anterolateral wall is strongly joined to the vaginae conjunctivi of the nervi glossopharyngeus, vagus, accessorius, to the wall of the sinus petrosus inferior and to the fossa jugularis. The posteromedial wall is weakly attached to the incisura jugularis os occipitale. At the level of the inferior bony border of the foramen jugulare, the vascular wall is adhesive to the periosteum and is reinforced by fibrous septum which originate from the superior portion of the vagina carotica. PMID:7158786

Piffer, C R; Zorzetto, N L

1982-01-01

300

Mesoscopic study on the bulbus venae jugularis superior.  

UK PubMed Central (United Kingdom)

Mesoscopic observations on the bulbus venae jugularis superior showed that the anterolateral wall is strongly joined to the vaginae conjunctivi of the nervi glossopharyngeus, vagus, accessorius, to the wall of the sinus petrosus inferior and to the fossa jugularis. The posteromedial wall is weakly attached to the incisura jugularis os occipitale. At the level of the inferior bony border of the foramen jugulare, the vascular wall is adhesive to the periosteum and is reinforced by fibrous septum which originate from the superior portion of the vagina carotica.

Piffer CR; Zorzetto NL

1982-01-01

 
 
 
 
301

Systemic Dexamethasone and its Effect on Normal Aerobic Bacterial Flora of Cow  

Directory of Open Access Journals (Sweden)

Full Text Available This study was carried out on 17 Holestein, heifers, aged between 1 to 2 years for determining the normal aerobic bacterial flora and their changes after dexamethasone injection. Swab samples were taken from eye, ear, pharynx and vagina before and 5 days after twice dexamethasone treatment. Results indicated that Bacillus cereus and Corynebacterium pseudotuberculosis had higher frequency of isolations than the other bacterial flora in eye, ear and pharynx. Actinomyces pyogenes was isolated with considerable frequency from vagina. Klebsiella pneumoniae was also isolated from pharynx and its frequency was increased significantlyafter dexamethasone injection (p<0.05).

Gholam-Ali Kojouri; Azizollah Ebrahimi; Farzaneh Nikookhah

2007-01-01

302

Acesso sagital transretal anterior (ASTRA) para vaginoplastia após complicação de anoretoplastia sagital posterior/ Anterior sagittal transrectal approach (ASTRA) for vaginoplasty after complications of posterior sagittal anorectoplasty  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A exposição transperineal de altas vaginas é limitada. Essas limitações podem ser contornadas usando ASTRA (anterior sagital transrectal approach). Relatamos o uso desta estratégia cirúrgica para o tratamento de um caso de atresia vaginal adquirida, após anorretoplastia posterior, em caso de malformação anorretal. Abstract in english Transperineal exposure of the high portion of the vagina is limited. These limitations can be circumvented using ASTRA (anterior sagittal transrectal approach). We report the use of this surgical strategy for the treatment of a case of acquired vaginal atresia after posterior anorectoplasty due to anorectal malformation.

Jesus, Lisieux Eyer de; Helman, Laura; Dekermacher, Samuel; Bernardo, Raquel L.; Martinez, Cruz Delia M.

2013-06-01

303

The McKusick-Kaufman hydrometrocolpos-polydactyly syndrome: A rare case report.  

UK PubMed Central (United Kingdom)

A combination of hydrometrocolpos, polydactyly, and cardiac anomlies is the cardinal feature of McKusick-Kaufman syndrome. Neonatal hydrometrocolpos is rare Mullerian duct anomaly caused by obstruction of the vagina. There is an accumulation of mucus secretions proximal to the obstruction. The secretions are secondary to intrauterine and postnatal stimulation of uterine and cervical glands by maternal estrogens. Here, we report a case of 1-day-old neonate who presented with abdominal distension. Ultrasound and computed tomography findings revealed a large abdominopelvic cystic mass posterior to the urinary bladder. Other associated findings were polydactyly and bilateral hydronephosis. Laparotomy confirmed the findings of hydrometrocolpos caused by stenosis/atresia of lower vagina.

Yewalkar SP; Yadav VK; Khadse G

2013-04-01

304

Intraperitoneal leech: A rare complication of leech bite.  

Science.gov (United States)

An intraperitoneal leech, which entered through vagina and uterus in a 2-year-old girl is reported. The child presented with intraperitoneal hemorrhage and shock. A leech inside the peritoneal cavity has never been reported in the literature. PMID:22121316

Saha, Manoj; Nagi, Sedengulie

2011-10-01

305

INCONTINENCE TREATMENT WITH URETHRAL GUIDE  

UK PubMed Central (United Kingdom)

Devices and methods for aligning a probe body and a treatment surface adjacenta target tissue. A guide shaft can be positioned in a urethra. The probe body canbe positioned in a vagina and registered relative to the guide so as to positionthe treatment surface in alignment with the target tissue.

MATLOCK George L.

306

Incontinence treatment with urethral guide  

UK PubMed Central (United Kingdom)

Devices and methods for aligning a probe body and a treatment surface adjacent a target tissue. A guide shaft can be positioned in a urethra. The probe body can be positioned in a vagina and registered relative to the guide so as to position the treatment surface in alignment with the target tissue.

MATLOCK GEORGE L

307

Human vaginal epithelial immunity and influences of hormonal contraceptive usage  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The vagina is the port of entry for sexually transmitted diseases in women. Its epithelium constitutes the luminal border, thus comprising an important defence barrier. The objective of this work was to investigate the mechanisms of importance in the immune defence of the vaginal epithelium of healt...

Ildgruben, Anna

308

[Surgical treatment in a case of partial vaginal obliteration coexisting with hematometra, hematocolpos and other congenital defects  

UK PubMed Central (United Kingdom)

A case history of 12 years old girl with transverse vaginal septum occurring with hematometra, hematocolpos and other congenital defects is presented. Operation was carried out twice because of vaginal prosthetic appliance after the first operation. The reoperation was done 6 months after the previous one and artificial vagina recanalised.

Goluda M; Roszyk-Rybi?ska A; Gasi?ska-Drozdowska I; Hirowska-Tracz M

1999-05-01

309

Prevention of cervical, vaginal, and vulval cancers: role of the quadrivalent human papillomavirus (6, 11, 16, 18) recombinant vaccine  

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The relationship between the human papillomavirus (HPV) and malignancies of the uterine cervix, vagina, and vulva has been established. The development of a quadrivalent HPV recombinant prophylactic vaccine represents the first time in history that primary prevention of these cancers is offered to g...

Diaz, Maria Lina

310

Evaluation of a rapid optical immunoassay-based test for group B streptococcus colonization in intrapartum patients.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To compare an optical immunoassay (OIA) rapid diagnostic kit to standard culture for the diagnosis of vaginal colonization with group B streptococcus (GBS) and to assess the accuracy and reproducibility of the OIA results. METHOD: A total of 301 patients in labor were prospectively evaluated for GBS colonization with a test approved by the Food and Drug Administration (STREP B OIA kit, Biostar, Boulder, CO, USA) and by culture. The vagina was simultaneously sampled with two swabs. Rectal culture was obtained separately. RESULTS: By the criterion of a positive culture, the vagina was colonized by GBS in 33 of 301 (11%) patients; and the rectum in 42 of 301 (13.9%). The vagina or rectum or both were colonized by CBS in 54 of 301 (17.9%) of patients. The OIA had sensitivity, specificity, positive predictive value and negative predictive value of 63.6%, 86.3%, 37.5% and 94.8%, respectively. The OIA had a kappa statistic score of 0.59. CONCLUSION: The OIA is not an adequately sensitive rapid kit for reliable detection of GBS colonization of the vagina. The results of the OIA were only moderately accurate and reproducible.

Samadi R; Stek A; Greenspoon JS

2001-06-01

311

Vaginal and bladder angiosarcoma after therapeutic irradiation  

International Nuclear Information System (INIS)

Angiosarcoma involving the female genitourinary tract is a rare soft tissue malignancy of vascular origin. We have described probably the first reported case of postirradiation angiosarcoma involving the vagina and bladder, and have reviewed the existing literature on the subject of angiosarcoma resulting from previous therapeutic irradiation for gynecologic malignancy.10 references

1989-01-01

312

Vaginal epithelioid angiosarcoma.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A case of epithelioid angiosarcoma of the vagina is described. Only five cases of angiosarcoma at this site have been reported, three of which followed radiotherapy for other gynaecological malignancies. None is described as an epithelioid angiosarcoma, an unusual and recently described variant whic...

McAdam, J A; Stewart, F; Reid, R

313

Intestinal Infarctus following Dilatation and Uterine Curettage.  

Science.gov (United States)

We present a case of intestinal infarctus through the vagina. This was a consequence of induced abortion done clandestinely. The main objective was to point out the surgical complications of uterine dilatation and curettage by means of this rare case. PMID:21490851

Ngowe, N M; Atangana, R; Eyenga, V C; Sosso, M A

2008-03-25

314

Hysterectomy  

Medline Plus

Full Text Available ... X-Plain.com og010104 Last reviewed: 3/18/2009 1 The female reproductive organs include: • Vagina • Uterus • ... X-Plain.com og010104 Last reviewed: 3/18/2009 2 These hormones also prepare the inner lining ...

315

Immune Cell-Mediated Protection against Vaginal Candidiasis: Evidence for a Major Role of Vaginal CD4+ T Cells and Possible Participation of Other Local Lymphocyte Effectors  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The protective roles of different lymphocyte subsets were investigated in a rat vaginal candidiasis model by adoptive transfer of vaginal lymphocytes (VL) or sorted, purified CD3+ T cells, CD4+ or CD8+ T cells, or CD3? CD5+ B cells from the vaginas of naïve or immune rats following three rounds of C...

Santoni, Giorgio; Boccanera, Maria; Adriani, Daniela; Lucciarini, Roberta; Amantini, Consuelo; Morrone, Stefania

316

Candida-specific Th1-type responsiveness in mice with experimental vaginal candidiasis.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The role of systemic cell-mediated immunity (CMI) as a host defense mechanism in the vagina is poorly understood. Using a murine pseudoestrus model of experimental vaginal candidiasis, we previously found that animals given a vaginal inoculum of viable Candida albicans blastoconidia acquired a persi...

Fidel, P L; Lynch, M E; Sobel, J D

317

A Novel Itraconazole Bioadhesive Film for Vaginal Delivery: Design, Optimization, and Physicodynamic Characterization  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The purpose of this work was to design and optimize a novel vaginal drug delivery system for more effective treatment against vaginal candidiasis. Itraconazole was formulated in bioadhesive film formulations that could be retained in the vagina for prolonged intervals. The polymeric films were prepa...

Dobaria, Nitin B.; Badhan, A. C.; Mashru, R. C.

318

Xanthogranulomatous oophoritis: a case report  

Energy Technology Data Exchange (ETDEWEB)

A case of xantho granulomatous oophoritis is presented in a patient who had a 3-month history of intrapelvic mass protruding into the vagina. The sonographic findings are a well defined mass shadowing lower echogenicity than the echo of the uterus at the posteosuperior aspect of the uterus. The CT findings are an enhancing solid mass with central necrosis containing a multiseptated cystic component.

Yang, Ik; Ko, Young Tae; Lee, Dong Ho; Lim, Jae Hoon; Choi, Woo Suk [Kyung Hee University Hospital, Seoul (Korea, Republic of)

1992-01-15

319

Clear cell renal cell carcinoma with vaginal and brain metastases: a case report and literature review  

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There are very few cases of clear cell renal cell carcinoma with metastases to the vagina and brain reported in the literature. Our case study highlights this rare clinical occurrence and its associated complications including pulmonary embolism. In addition we discuss current management guidelines ...

Tobe Samuel Momah; Dhanan Etwaru; Phillip Xiao; Vasantha Kondamudi

320

The fingerprint, a false-positive fern test.  

UK PubMed Central (United Kingdom)

Microscope slides were prepared to confirm the presence of ferning from a 32-week gestation with possible premature rupture of the membranes. Although no amniotic fluid was seen in the vagina, an atypical ferning pattern was produced and was again reproducible with fingerprints on the glass slide. Guidelines to recognize and avoid this source of error are outlined.

Lodeiro JG; Hsieh KA; Byers JH; Feinstein SJ

1989-05-01

 
 
 
 
321

"You Want Me to Talk to Children about What?" Responding to the Subject of Sexuality Development in Young Children  

Science.gov (United States)

Many people think it is taboo to talk about sex with children. Adults reinforce this belief when, for example, they use substitute words rather than "vagina" or "penis". They may be embarrassed to learn about children's sexual development or ask others for assistance. Although most people in US society are open about sexuality now, the topic of…

Sciaraffa, Mary; Randolph, Theresa

2011-01-01

322

Magnetic resonance imaging visualization of a vaginal septum.  

UK PubMed Central (United Kingdom)

Magnetic resonance imaging is considered the gold-standard imaging technique in cases of Müllerian and vaginal anomalies, however, vaginal delineation often proves difficult, owing to the fact that vaginal walls are normally collapsed and in close proximity. Instilling gel through the introitus allows for better depiction of the distal vagina.

Papaioannou G; Koussidis G; Michala L

2011-11-01

323

CUERPO EXTRAÑO INTRAVAGINAL SECUNDARIO A MIGRACIÓN DE AGUJA DE OSTEOSÍNTESIS DE CADERA  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Se presenta caso clínico de migración de aguja de fijación de artroplastia de cadera a vagina en mujer embarazada Abstract in english We report a case of an intravaginal foreign body due to migration of needle hip fixation from hip arthroplasty in a pregnant woman

Perucca P, Ernesto; Reyes S, Marcelo; Diez C, María José; Veloz T, Marcela

2007-01-01

324

Accessory Reproductive Organs Dimension of Two Species of Giant African Land Snails Archachatina marginata and Achatina achatina at Three Liveweight Ranges  

Directory of Open Access Journals (Sweden)

Full Text Available A comparative study of the reproductive tract of two species of Giant African Land Snails, Archachatina marginata and Achatina achatina was carried out. Three groups of snails weighing 80-100,101-150 and 151-250 g were used in a 2x3 factorial design, with 5 replicates, involving a total of 30 snails. Dimensions and weights of retractor penile muscle, vas deferens, penis, vagina, oviduct, spermotheca, common duct, albumen gland and little hermaphrodite duct were taken. Results showed that Archachatina marginata had longer, wider and heavier accessory sex organs compared to Achatina achatina except for vas deferens width, vagina length, vagina width, and vagina weight, which were otherwise. Dimensions and weights of the accessory organs increased consistently with liveweight, except for retractor penile muscle width, which had attained maximum size by a body weight of 101-150 g. It can be concluded that Archachatina marginata had better reproductive tract dimension compared to their counterpart (Achatina achatina). It is however recommended that liveweight group 151-250 g be considered as group of choice when considering anatomical display of reproductive parts for demonstrative purpose and testing of manipulating tools for reproductive strategies in both species.

J. A. Abiona; O. A. Osinowo; D. Eruvbetine; M.O. Abioja; O. F. Smith; J. O. Daramola; A. O. Ladokun; I. J. James; O. S. Abe; O. M. Onagbesan

2012-01-01

325

Vaginal Birth  

Medline Plus

Full Text Available ... During pregnancy, the baby is in a special fluid called amniotic fluid. The baby and amniotic fluid are in a bag called the “amniotic sac” ... the amniotic sac opens up and the amniotic fluid seeps out through the vagina. When this happens, ...

326

C-Section  

Medline Plus

Full Text Available ... During pregnancy, the baby floats in a special fluid called amniotic fluid. Both the baby and amniotic fluid are in a bag called the “amniotic sac.” ... sac opens before the actual delivery and amniotic fluid seeps out through the vagina. When this happens, ...

327

[Post-coital vesicovaginal fistula after treatment for cervical cancer. Cure by prolonged bladder drainage after epiploplasty failure. Two cases  

UK PubMed Central (United Kingdom)

Post-coitus vagina-bladder fistulas are rarely encountered although they may be favoured by radiosurgical treatment for cervical cancer. Treatment is particularly difficult. When initial epiploplasty is a failure, most authors recommend an ileocytoplasty with ad integrum reconstruction of the vaginal and of bladder function.

Bobin JY; Gratadour AC; Delay E; Rivoire M

1995-01-01

328

Vaginal Birth  

Medline Plus

Full Text Available ... X-Plain.com og190102 Last reviewed: 08/07/2007 1 Pregnancy During pregnancy, the baby is in ... X-Plain.com og190102 Last reviewed: 08/07/2007 2 through the cervix and vagina and comes ...

329

Partial vaginismus : definition, symptoms and treatment  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Vaginismus is a sexual pain disorder, where spasm of musculature of the outer third of the vagina interferes with intercourse. Vaginismus exists in two forms: total vaginismus, where intercourse is impossible, and the more seldom described partial vaginismus, in which intercourse is possible but pai...

Engman, Maria

330

PROBIOTIC PROPERTIES OF VAGINAL LACTIC ACID BACTERIA SELECTED FOR HARMONIZATION OF MICROENVIRONMENT OF REPRODUCTIVE APPARATUS  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The aim of this study was isolation and screening of probiotic properties of Lactobacillus strains isolated from the vagina of heifers and cows with healthy reproductive apparatus. Initially tested properties were low pH tolerance, growth at different temperature, autoaggregation, fast growth and a...

Eva Styková; Igor Valocký; František Novotný; Peter Guba

331

Mayer-Rokitansky-Kuster-Hauser Syndrome diagnosed by Magnetic Resonance Imaging. Role of Imaging to identify and evaluate the uncommon variation in development of the female genital tract  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a spectrum of Müllerian duct anomalies characterized by congenital aplasia of the uterus and of the upper part (2/3) of the vagina, in young women presenting otherwise with normal endocrine status. The ovaries and fallopian tubes are present. It is o...

Fiaschetti, Valeria; Taglieri, Amedeo; Gisone, Vito; Coco, Irene; Simonetti, Giovanni

332

Mayer-Rokitansky-Küster-Hauser syndrome associated with a urogenital sinus anomaly in a 4-year-old : report of a case  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare entity characterized by congenital aplasia of the vagina and uterus in the presence of normal ovarian function, in conjunction with a 46 XX karyotype. This condition is mostly signalled by primary amenorrhoea around the season of puberty. ...

Adam, Ahmed; Ebrahim, Zaeem I.; Engelbrecht, Matthys J.; Van Heerden, Izak J.; Moshokoa, Evelyn M.

333

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part (2/3) of the vagina in women showing normal development of secondary sexual characteristics and a normal 46, XX karyotype. It affects at least 1 out of 4500 women. MRKH may be i...

Morcel, Karine; Camborieux, Laure; Guerrier, Daniel

334

The Mayer-Rokitansky-Küster-Hauser Syndrome. A descriptive study of radiological and physical signs.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital syndrome in which the uterus and vagina are absent. Associated disorders mentioned in the literature include: Congenital renal disorders, cengenital abnormalities of the vertebral column, congenital abnormalities of the upper extremi...

Strübbe, Ernst Hendrik,

335

Utero-vaginal aplasia (Mayer-Rokitansky-Küster-Hauser syndrome) associated with deletions in known DiGeorge or DiGeorge-like loci.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

BACKGROUND: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part of the vagina in women showing normal development of secondary sexual characteristics and a normal 46, XX karyotype. The uterovaginal aplasia is either isolated (type I)...

Morcel, Karine; Watrin, Tanguy; Pasquier, Laurent; Rochard, Lucie; Le Caignec, Cédric; Dubourg, Christèle; Loget, Philippe

336

EXPERIENCES WITH MC INDOES VAGINOPLASTY IN MAYER –ROKITANSKY- KUSTER- HAUSER SYNDROME-A CASE SERIES  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background:- Vaginal agenesis or developmental absence of the vagina is one of the major  congenital anomalies of the female genital tract. It is estimated to occur in 1 in 4,000-5,000 live female births.It may present either as an isolated developmental defect ...

Vidyadhar B Bangal; Kundankumar N. Dandekar; Kishor C. Gadhave; Rashmi K Singh

337

Utero-vaginal aplasia (Mayer-Rokitansky-Küster-Hauser syndrome) associated with deletions in known DiGeorge or DiGeorge-like loci  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part of the vagina in women showing normal development of secondary sexual characteristics and a normal 46, XX karyotype. The uterovaginal aplasia is...

Morcel Karine; Watrin Tanguy; Pasquier Laurent; Rochard Lucie; Le Caignec Cédric; Dubourg Christèle; Loget Philippe

338

Mayer-Rokitansky-Kuster-Hauser Syndrome: Embryology, Genetics and Clinical and Surgical Treatment  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a pathological condition characterized by primary amenorrhea and infertility and by congenital aplasia of the uterus and of the upper vagina. The development of secondary sexual characters is normal as well as that the karyotype (46,XX). Etiologicall...

Pizzo, Alfonsa; Laganà, Antonio Simone; Sturlese, Emanuele; Retto, Giovanni; Retto, Annalisa; De Dominici, Rosanna

339

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part (2/3) of the vagina in women showing normal development of secondary sexual characteristics and a normal 46, XX karyotype. It affects at least 1 out of 4500 w...

Morcel Karine; Camborieux Laure

340

Mayer-Rokitansky-Kuster-Hauser Syndrome: Surgical Management of Two Cases  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Mayer-Rokitansky-Kuster-Hauser (MRKH) Syndrome is a rare anomaly characterized by congenital aplasia of the uterus and vagina in women showing normal development of secondary sexual characters and normal 44 XX karyotype. We report our experience in the management of two patients with congenital ...

Mungadi, I. A.; Ahmad, Y.; Yunusa, G. H.; Agwu, N. P.; Ismail, S.

 
 
 
 
341

Urogenital tumors  

Energy Technology Data Exchange (ETDEWEB)

An overview is provided for veterinary care of urogenital tumors in companion animals, especially the dog. Neoplasms discussed include tumors of the kidney, urinary bladder, prostate, testis, ovary, vagina, vulva and the canine transmissible venereal tumor. Topics addressed include description, diagnosis and treatment.

Weller, R.E.

1994-03-01

342

Mucosal vulval lichen planus: outcome, clinical and laboratory features.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Mucosal lichen planus of the vulva is a rare but increasingly recognized condition. It has potentially severe complications such as fusion of the labia and vagina; the risk of developing squamous cell carcinoma (SCC) may be increased. An association between hepatitis B and C infection and skin or or...

Kirtschig, G; Wakelin, SH; Wojnarowska, F

343

Vesico-vaginal fistula repair as a day case: is it a worthy venture?  

UK PubMed Central (United Kingdom)

Two vesico-vaginal fistula patients who were successfully managed with outpatient care as an alternative approach, to ensure early access to care and integration into their family. The two patients had simple uncomplicated mid-vagina fistulae surgically repaired with local infiltrative anaesthesia. We suggest some selection criteria and clinical guidelines that can facilitate successful treatment by this choice of care.

Ojengbede OA; Morhason-Bello IO

2013-10-01

344

Childhood lichen sclerosus is a rare but important diagnosis  

DEFF Research Database (Denmark)

Lichen sclerosus (LS) is a chronic skin disorder with a predilection for the anogenital area. The disease is mostly seen in prepubertal and postmenopausal females. The lesions present as sharply demarcated white plaques encircling the vagina and anus. The atrophic form can lead to scarring of the affected area.

Jensen, Lise Soldbro; Bygum, Anette

2012-01-01

345

Xanthogranulomatous oophoritis: a case report  

International Nuclear Information System (INIS)

A case of xantho granulomatous oophoritis is presented in a patient who had a 3-month history of intrapelvic mass protruding into the vagina. The sonographic findings are a well defined mass shadowing lower echogenicity than the echo of the uterus at the posteosuperior aspect of the uterus. The CT findings are an enhancing solid mass with central necrosis containing a multiseptated cystic component.

1992-01-01

346

Oxytocin determination by radioimmunoassay in cattle. 2. Effect of mating and stimulation of the genital tract in bulls, cows and heifers  

Energy Technology Data Exchange (ETDEWEB)

Oxytocin concentration in jugular vein blood was measured radioimmunologically with a detection limit of 3 pg/ml plasma in male and female cattle. Five bulls were tested; during mating a cow in oestrus with intromission and ejaculation, during mounting a dummy or another bull with ejaculation into an artificial vagina or during false mounts. No increase in oxytocin concentrations could be observed, but stimulation with an electro-ejaculator caused an increase ranging from 5-84 pg/ml after a latent period of 3-5 min. A similar response was observed in two cows following the same procedure. The contact with a bull, false mount or mating with intromission and ejaculation was not followed by a measurable oxytocin release in 5 test cows. The following stimulation techniques, massage of vulva and clitoris, massage of cervix and uterus per rectum, artificial insemination, introduction of a speculum into the vagina or insufflation of air into the vagina were performed with 5 cows and 5 heifers. Insufflation of air into the vagina was the most effective stimulus, eleciting an oxytocin release up to 588 pg/ml. All 5 heiers responded positively, as well as 4 cows in oestrus. The other manipulations cuased an oxytocin response mainly in heifers (whether in oestrus or dioestrus), whereas only one cow in oestrus responded with an oxytocin release. In general, oxytocin concentrations increase about 30-90 s after the start of the stimulus.

Schams, D.; Baumann, G. (Institut fuer Physiologie der Sueddeutschen Versuchs- und Forschungsanstalt fuer Milchwirtschaft der TU Muenchen); Leidl, W. (Gynaekologische und Ambulatorische Tierklinik der Universitaet Muenchen, Germany)

1982-01-01

347

Oxytocin determination by radioimmunoassay in cattle. 2  

International Nuclear Information System (INIS)

Oxytocin concentration in jugular vein blood was measured radioimmunologically with a detection limit of 3 pg/ml plasma in male and female cattle. Five bulls were tested; during mating a cow in oestrus with intromission and ejaculation, during mounting a dummy or another bull with ejaculation into an artificial vagina or during false mounts. No increase in oxytocin concentrations could be observed, but stimulation with an electro-ejaculator caused an increase ranging from 5-84 pg/ml after a latent period of 3-5 min. A similar response was observed in two cows following the same procedure. The contact with a bull, false mount or mating with intromission and ejaculation was not followed by a measurable oxytocin release in 5 test cows. The following stimulation techniques, massage of vulva and clitoris, massage of cervix and uterus per rectum, artificial insemination, introduction of a speculum into the vagina or insufflation of air into the vagina were performed with 5 cows and 5 heifers. Insufflation of air into the vagina was the most effective stimulus, eleciting an oxytocin release up to 588 pg/ml. All 5 heiers responded positively, as well as 4 cows in oestrus. The other manipulations cuased an oxytocin response mainly in heifers (whether in oestrus or dioestrus), whereas only one cow in oestrus responded with an oxytocin release. In general, oxytocin concentrations increase about 30-90 s after the start of the stimulus. (author)

1982-01-01

348

[Construction of a neo-clitoris in male-to-female transsexuals  

UK PubMed Central (United Kingdom)

To preserve the ability of orgasm in male-to-female transsexuals we retain the glans-penis and the corpus cavernosum urethrae as a unit. The glans-penis will be placed into the anterior wall of the neo-vagina under the symphysis as the neo-clitoris.

von Szalay L

1990-09-01

349

Antimicrobial factors in the cervical mucus plug  

DEFF Research Database (Denmark)

The cervical mucus plug is positioned between the microbe-rich vagina and the normally sterile uterine cavity, which suggests a host defense function, but few relevant data are available. We analyzed the composition and antimicrobial activity of cervical mucus plugs.

Hein, Merete; Valore, Erika V

2002-01-01

350

Small Bowel Evisceration Following Vaginal Hysterectomy is a General Surgical Emergency–A Case Report and Review of the Literature  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Small bowel evisceration through the vagina is a rare condition, which tends to affect post-menopausal women who have undergone vaginal hysterectomy. It is a surgical emergency with a favourable outcome if diagnosed and treated in a timely fashion. Delay in diagnosis can precipitate infarction of sm...

Mandana Sigaroudinia; David Bowden; Deb Maitra; Graham Cawdell

351

Postcoital Transvaginal Evisceration After Hysterectomy: a Case Report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Transvaginal evisceration is mostly seen at postmenopausal period in a case who had vaginal operation and at premenopausal period it ensues postcoitally after hysterectomy. A 47 year old patient presented to emergency department with a complaint of intestinal herniation through vagina after coitus t...

Oktay Büyüka??k; Önder Koç; A.O?uz Hasdemir; Cavit Çöl; Hayri Erkol

352

Uterine didelphys with cervical incompetence  

Directory of Open Access Journals (Sweden)

Full Text Available Uterine didelphys represents a uterine malformation where the uterus is present as a paired organ. There is presence of double uterine bodies with two separate cervices, and often a double or septate vagina as well. We report a case of single pregnancy in the right sided uterine body of a didelphic uterus with cervical incompetence.

Aher Gautam S, Gavali Urmila G, Kulkarni Meghana

2013-01-01

353

Real-time three-dimensional ultrasound visualization of erection and artificial coitus.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

To investigate the feasibility of imaging penile erection and coitus in real time and in three dimensions, a 'Live' three-dimensional (3-D) ultrasound system was used to acquire the volume of interest at 25 Hz from five healthy men. Water baths and gel-made artificial vaginas were devised to facilit...

Deng, J; Hall-Craggs, MA; Pellerin, D; Linney, AD; Lees, WR; Rodeck, CH; Todd-Pokropek, A

354

Successful management of vaginismus: An eclectic approach  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Vaginismus is defined as recurrent or persistent involuntary spasm of the musculature of the outer third of the vagina, which interferes with coitus and causes distress and interpersonal difficulty. In this report, we describe the successful treatment of vaginismus in a 25-year-old lady based on a m...

Harish, Thippeswamy; Muliyala, KrishnaPrasad; Murthy, Pratima

355

Structure, function and diversity of the healthy human microbiome  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this diversity remains unexplained, although diet, environment, host genetics and early microbial exposure have all been implic...

Alm, Eric J.; Friedman, Jonathan; Smillie, Christopher S.

356

Clear cell renal cell carcinoma with vaginal and brain metastases: a case report and literature review  

Directory of Open Access Journals (Sweden)

Full Text Available There are very few cases of clear cell renal cell carcinoma with metastases to the vagina and brain reported in the literature. Our case study highlights this rare clinical occurrence and its associated complications including pulmonary embolism. In addition we discuss current management guidelines for treating and diagnosing the disease, and how this management improves prognosis.

Tobe Samuel Momah; Dhanan Etwaru; Phillip Xiao; Vasantha Kondamudi

2009-01-01

357

Use of Gen-Probe AccuProbe Group B streptococcus test to detect group B streptococci in broth cultures of vaginal-anorectal specimens from pregnant women: comparison with traditional culture method.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Detection of vaginal-anorectal colonization with group B streptococci (GBS) is critical to the prevention of neonatal GBS disease. The recommended method for the detection of GBS is culture of the distal vagina and anorectum in a selective broth medium followed by subculture to solid media and ident...

Bourbeau, P P; Heiter, B J; Figdore, M

358

Colonization Rate of Group B Streptococcus (GBS) in Pregnant Women Using GBS Agar Medium  

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Group B streptococci (GBS) or Streptococcus agalactiae are members of the normal flora of the female genital tract. GBS normally colonizes the vagina in many women asymptomatically. During labor this organism may infect the newborn, leading to neonatal sepsis and meningitis. This study aimed to inve...

Fatemi F; Chamani L; Pakzad P; Zeraati H; Rabbani H; Asgari S

359

Neo-bladder vaginal fistula: An unusual complication after orthotopic urinary diversion  

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Development of neo-bladder vaginal fistula is not an unknown complication after cystectomy and orthotopic urinary diversion in females. Compared to native bladder, the wall of the neo-bladder is much thinner that may render it vulnerable to fistulization. Injury to the vagina during cystectomy is th...

Kumar Abhay; Das Suren; Trivedi Sameer; Dwivedi Udai; Singh Pratap

360

[Parametrial coitus  

UK PubMed Central (United Kingdom)

We saw an 18-year-old female patient with a practically imperforated and thickened hymen who, during an attempt at intercourse, suffered traumatic penetration in the right parametrium, parallel to the vagina. The hymen was opened further. The girl recovered completely.

Vierhout ME; Straub MJ

1993-04-01

 
 
 
 
361

VALIDEZ DE LA PRUEBA DE HISTERECTOMÍA VAGINAL EN PACIENTES CON INDICACIÓN DE VÍA ABDOMINAL MANDATORIA  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Objetivo: Evaluar la histerectomía vaginal en la resolución de patología uterina benigna, en casos que habitualmente se resuelven por histerectomía abdominal. Método: Estudio prospectivo en 68 pacientes sometidas a histerectomía vaginal en el Servicio de Ginecología del Hospital Claudio Vicuña, de San Antonio, entre junio de 2003 a junio de 2009. Son pacientes sin partos vaginales, algunas nuligestas, la mayoría con cicatrices de cesárea o historia de cirugía p (more) élvica previa. Se separan en dos grupos, uno de dificultad moderada (DM) (útero móvil, vagina >2 dedos de diámetro, fondos de saco bien conformados) y otro de dificultad severa (DS) (útero fijo, vagina Abstract in english Objective: To assess vaginal hysterectomy in benign uterine pathology resolution in cases who are usually resolved by abdominal hysterectomy. Method: We studied, prospectively, 68 patients that were operated by vaginal hysterectomy between june 2003 to june 2009 in the Gynecology Service at Claudio Vicuña Hospital, San Antonio. Most of the patients have history of prior cesarean section or pelvic surgery, but no one has had vaginal deliveries, inclusive, some of them, ha (more) ve no history of previous pregnancies. The patients were separated into two groups, moderate difficulty (MD): composed by patients with uterus conserved motility, vagina >2 fingers diameter, well conserved cul de sac, and severe difficulty (SD): composed by patients with none uterine motility, vagina

Riquelme P, Juan; Fuentes L, Luis; Araya T, Marcela; Rojas P, Carlos

2010-01-01

362

Spindle cell epithelioma: a rare vaginal tumor -a clinico pathologic report.  

UK PubMed Central (United Kingdom)

Spindle cell epithelioma is a very rare benign tumour of the vagina, which contains epithelial and mesenchymal components and co-expresses the markers for both. It has its origin in the epithelial cells of the remnants of the vestibular gland. The presence of glandular structures and the pattern of immunostaining, help in the differentiation of these tumours from the other common vaginal tumours.

K N; Sowmya; Shanthini F

2013-08-01

363

Vesico-vaginal fistula repair as a day case: is it a worthy venture?  

Science.gov (United States)

Two vesico-vaginal fistula patients who were successfully managed with outpatient care as an alternative approach, to ensure early access to care and integration into their family. The two patients had simple uncomplicated mid-vagina fistulae surgically repaired with local infiltrative anaesthesia. We suggest some selection criteria and clinical guidelines that can facilitate successful treatment by this choice of care. PMID:23695384

Ojengbede, O A; Morhason-Bello, I O

2013-05-22

364

[Vaginal ecology, climate, landscapes and populations (xenoecies and facies)  

UK PubMed Central (United Kingdom)

Brief study of vaginal populations, the human vagina being considered as a biotopic cavity. Allusion to dynamic aspects ("vaginal climate", "landscapes") and to various bacterial populations. Introduction of the concept of xenoecies and of facies. This study is preceded by essential definitions of terms widely used in ecology.

Nicoli JM; Nourrit J; Michel-Nguyen A; Sempe M; Nicoli RM

1994-06-01

365

Efficacy of Albaconazole against Candida albicans in a Vaginitis Model?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The efficacy of albaconazole (ABC) was evaluated using a murine model of vaginal Candida albicans infection. Both ABC and fluconazole (FLC) were effective in reducing the fungal load from vaginas of infected mice; however, ABC demonstrated encouraging activities against an FLC-resistant strain, with...

González, Gloria M.; Robledo, Efrén; Garza-González, Elvira; Elizondo, Mariana; González, J. Gerardo

366

Abdominal pregnancy with a full term live fetus: Case report  

Directory of Open Access Journals (Sweden)

Full Text Available This is a case report of an abdominal pregnancy that was carried to term with live fetus. Illiteracy, poverty and lack of antenatal care had resulted in her late presentation. Bleeding per vagina, persistence abdominal pain, weight loss and pallor were the main clinical features. She had laparotomy and delivery of a live fetus.

Isah A; Ahmed Y; Nwobodo E; Ekele B

2008-01-01

367

Vaginal Birth  

Medline Plus

Full Text Available ... vagina, which opens to the outside of the body between the urethra (the urinary bladder opening) and ... mother’s blood does NOT go into the baby’s body. When it is almost time for the baby ...

368

No Increased Risk for Most Cancers Yet Observed in Daughters of Women Exposed to DES in the 1940s and 1950s  

Science.gov (United States)

The first systematic follow-up study of a large group of women, whose mothers were given the synthetic estrogen diethylstilbestrol (DES) during pregnancy in the 1940s and 1950s, found no increase in any type of cancer except for clear cell adenocarcinoma of the vagina and cervix in women under age 30.

369

Colostomía perineal en el carcinoma recto vaginal Perineal colostomy in recto-vaginal carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available Se realizó una variante quirúrgica en una paciente con cáncer recto-vaginal, con infiltración del tercio inferior y cara lateral derecha del recto, muy próximo al esfínter del ano. La técnica consistió, previo diagnóstico por biopsia, en realizar excérecis del tumor que comprometió al parapeto derecho y el tercio inferior de vagina, terminando con una colostomía perineal, conservando algunas fibras del esfínter del ano. Se dejó drenaje en ambos lados y se reconstruyó resto de la vagina. Se logró buena continencia rectal del paciente, con buen estado de satisfacción. No hubo complicaciones y actualmente defeca sin dificultad. Ha tenido seguimiento por consulta de Oncoginecología del Hospital III Congreso de Pinar del Río. La intervención se llevó a cabo en una hora.A surgical alternative was performed in a patient suffering from rectovaginal cancer infiltrating the lower third and lateral right aspect of the rectum, so closed to anal sphincter. Operative technique consisted of a previous diagnosis by biopsy, besides, exceresis of the tumor that compromised right pararectum and lower third of vagina, ending in perineal colostomy preserving some fibers of anal sphincter. Drainage was performed in both sides and the rest of the vagina was reconstructed. A good rectal continence and well being were obtained, observing no complications, the patient defecates without difficulties, this case is followed up at "III Congreso Hospital" in Pinar del Rio. Operative procedures lasted an hour.

Elpidio Barrial García; Miguel Alexis González Linares; Angel Miguel Sarmiento Vitón; Dianelys Ferrer Sánchez

2005-01-01

370

Efecto del método de obtención de semen de ovino sobre la calidad espermática (Effect of the method of obtaining of ovine semen on the spermatic quality)  

Directory of Open Access Journals (Sweden)

Full Text Available La colecta del semen del ganado ovino, ayuda a identificar problemas relacionados con el desempeño reproductivo de estos animales. Se han utilizado diferentes pruebas laboratoriales, para valorar la calidad seminal de los ovinos y poder realizar predicciones indirectas del potencial reproductivo de los machos reproductores; no obstante, su naturaleza subjetiva, no asegura el poder de fecundación de los machos. El objetivo de este trabajo fue valorar el efecto del método de obtención del semen de ovinos sobre la calidad espermática. Se empelaron 10 machos ovinos de la raza Suffolk de una Unidad de Producción Ovina, ubicada en el Estado de México, México. Para la recolección seminal se utilizó vagina artificial y directamente de la vagina, después de la monta natural. El semen fue valorado macro y microscópicamente. Los resultados promedios fueron, para vagina artificial: volumen 1.11 ml, pH 6.62, motilidad 64.5 %, concentración de espermatozoides/ml 206.4 x106, vivos 68.5 %, Muertos 31.87% y anormalidades 23.96%; directamente de la vagina: volumen 0.57 ml, pH 6.75, motilidad 60.4%, concentración de espermatozoides/ml 176.02 x 106, vivos 62.62 %, muertos 37.27% y anormalidades 11.12%. Los resultados indican que los resultados obtenidos con vagina artificial fueron los mejores. The collection of the semen of the livestock ovine, helps to identify problems related with the reproductive acting of these animals. They have been used different you prove laboratories, to value the seminal quality of the ovines and power to carry out indirect predictions of the reproductive potential of the reproductive males; nevertheless, its subjective nature, doesn't assure the power of fecundation of the males. The objective of this work was to value the effect of the method of obtaining of the ovines semen on the spermatic quality. You empelaron 10 male ovines of the race Suffolk of a Unit of Production Ovine, located in the State of Mexico, Mexico. For the seminal gathering artificial vagina was used and directly of the vagina, after it mounts it natural. The semen was valued macro and microscopically. The results averages were, for artificial vagina: volume 1.11 ml, pH 6.62, motility 64.5%, concentration of sperms/ml 206.4 x106, alive 68.5%, Dead 31.87% and abnormalities 23.96%; directly of the vagina: volume 0.57 ml, pH 6.75, motility 60.4%, sperms/ml concentration 176.02 x 106, alive 62.62%, dead 37.27% and abnormalities 11.12%. The results indicate that the results obtained with artificial vagina were the best.

Córdova-Izquierdo, Alejandro1*; ; ; y; Saltijeral Oaxaca, Jorge; Muñoz Mendoza, Ramiro; Córdova-Jiménez, M. Silvia; Guerra Liera J. Eulogio; Córdova-Jiménez C. Alejandro

2006-01-01

371

Vaginoplastia com utilização de enxerto de pele da região abdominal inferior Vaginoplasty using full-thickness skin graft from the lower abdominal region  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVOS: apresentar técnica de vaginoplastia e avaliar os seus resultados e complicações. MÉTODOS: foram incluídas 20 mulheres portadoras de ausência congênita de vagina, atendidas no período de 1989 a 1996, com idades entre 19 e 39 anos. A metodização dos tempos cirúrgicos consistia na abertura de uma cavidade entre o reto e a bexiga e no seu revestimento com enxerto de pele de espessura total retirado da região abdominal inferior, sendo a cavidade mantida com o uso de um molde dilatador e a área doadora suturada em primeira intenção. RESULTADOS: morfologicamente, em 75, 85 e 80% dos casos as vaginas apresentaram bom revestimento epitelial, boa elasticidade e boa amplitude, respectivamente. Funcionalmente, em 80% dos casos o ato sexual foi considerado satisfatório por ambos os cônjuges. CONCLUSÕES: a técnica apresentada possibilitou a obtenção de uma vagina adequada do ponto de vista anatomofuncional, a cicatrização rápida da área doadora em primeira intenção com bom aspecto estético e um baixo nível de complicações.PURPOSE: to present a technique of vaginoplasty and evaluate its results. METHODS: twenty women with congenital absence of the vagina aged between 19 and 39 years were included in the study. They were seen at the Endocrinological Gynecology and Climacteric Clinic of the Obstetrics and Gynecology Department of the Santa Casa of São Paulo, between 1989 and 1996. The surgery consisted of the opening of a cavity between the rectum and the bladder and this cavity was lined with a full-thickness skin graft removed from the lower abdominal region and kept in place with the use of a dilatation mold. The donor area was closed by primary suture. RESULTS: morphologically, in 75, 85 and 80% of the cases, the vagina presented a satisfactory epithelial lining, good elasticity and good amplitude, respectively. Functionally, in 80% of the cases both partners considered sexual intercourse satisfactory. CONCLUSIONS: the technique allows the obtention of an adequate vagina from the anatomic and functional point of view, fast healing of the donor area, closed by primary suture with good esthetical aspect and low level of complications.

José Arnaldo de Souza Ferreira

2003-01-01

372

Vaginoplastia com utilização de enxerto de pele da região abdominal inferior/ Vaginoplasty using full-thickness skin graft from the lower abdominal region  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVOS: apresentar técnica de vaginoplastia e avaliar os seus resultados e complicações. MÉTODOS: foram incluídas 20 mulheres portadoras de ausência congênita de vagina, atendidas no período de 1989 a 1996, com idades entre 19 e 39 anos. A metodização dos tempos cirúrgicos consistia na abertura de uma cavidade entre o reto e a bexiga e no seu revestimento com enxerto de pele de espessura total retirado da região abdominal inferior, sendo a cavidade mantida (more) com o uso de um molde dilatador e a área doadora suturada em primeira intenção. RESULTADOS: morfologicamente, em 75, 85 e 80% dos casos as vaginas apresentaram bom revestimento epitelial, boa elasticidade e boa amplitude, respectivamente. Funcionalmente, em 80% dos casos o ato sexual foi considerado satisfatório por ambos os cônjuges. CONCLUSÕES: a técnica apresentada possibilitou a obtenção de uma vagina adequada do ponto de vista anatomofuncional, a cicatrização rápida da área doadora em primeira intenção com bom aspecto estético e um baixo nível de complicações. Abstract in english PURPOSE: to present a technique of vaginoplasty and evaluate its results. METHODS: twenty women with congenital absence of the vagina aged between 19 and 39 years were included in the study. They were seen at the Endocrinological Gynecology and Climacteric Clinic of the Obstetrics and Gynecology Department of the Santa Casa of São Paulo, between 1989 and 1996. The surgery consisted of the opening of a cavity between the rectum and the bladder and this cavity was lined wi (more) th a full-thickness skin graft removed from the lower abdominal region and kept in place with the use of a dilatation mold. The donor area was closed by primary suture. RESULTS: morphologically, in 75, 85 and 80% of the cases, the vagina presented a satisfactory epithelial lining, good elasticity and good amplitude, respectively. Functionally, in 80% of the cases both partners considered sexual intercourse satisfactory. CONCLUSIONS: the technique allows the obtention of an adequate vagina from the anatomic and functional point of view, fast healing of the donor area, closed by primary suture with good esthetical aspect and low level of complications.

Ferreira, José Arnaldo de Souza

2003-02-01

373

Vaginal distribution and retention of a multiparticulate drug delivery system, assessed by gamma scintigraphy and magnetic resonance imaging.  

UK PubMed Central (United Kingdom)

BACKGROUND: For any new vaginal dosage form, the distribution and retention in the vagina has to be assessed by in vivo evaluation. We evaluated the vaginal distribution and retention of starch-based pellets in sheep as live animal model by gamma scintigraphy (using Indium-111 DTPA as radiolabel) and in women via magnetic resonance imaging (MRI, using a gadolinium chelate as contrast agent). A conventional cream formulation was used as reference in both studies. METHOD: Cream and pellets were administered to sheep (n=6) in a two period-two treatment study and to healthy female volunteers (n=6) via a randomized crossover trial. Pellets (filled into hard gelatin capsule) and cetomacrogol cream, both labeled with Indium-111 DTPA (for gamma scintigraphy) or with gadolinium chelate (for MRI) were evaluated for their intravaginal distribution and retention over a 24h period. Spreading in the vagina was assessed based on the part of the vagina covered with formulation (expressed in relation to the total vaginal length). Vaginal retention of the formulation was quantified based on the radioactivity remaining in the vaginal area (sheep study), or qualitatively evaluated (women study). RESULTS: Both trials indicated a rapid distribution of the cream within the vagina as complete coverage of the vaginal mucosa was seen 1h after dose administration. Clearance of the cream was rapid: about 10% activity remained in the vaginal area of the sheep 12h post-administration, while after 8h only a thin layer of cream was detected on the vaginal mucosa of women. After disintegration of the hard gelatin capsule, the pellet formulation gradually distributed over the entire vaginal mucosa. Residence time of the pellets in the vagina was longer compared to the semi-solid formulation: after 24h 23 ± 7% radioactivity was detected in the vaginal area of the sheep, while in women the pellet formulation was still detected throughout the vagina. CONCLUSION: A multi-particulate system containing starch-based pellets was identified as a promising novel vaginal drug delivery system, resulting in complete coverage of the vaginal mucosa and long retention time.

Mehta S; Verstraelen H; Peremans K; Villeirs G; Vermeire S; De Vos F; Mehuys E; Remon JP; Vervaet C

2012-04-01

374

Reconstructive surgical management of cryptomenorrhoea because of complete vaginal agenesis  

Directory of Open Access Journals (Sweden)

Full Text Available Background: The Vagina is a composite structure formed partly from the mullerian duct and partly from urogential sinus. Most of the patients with mullerian agenesis have small rudimentary uterus without any endometrial cavity, 7% - 8% may have functioning uterus. Case: A 15 years old girl admitted with primary amenorrhea, cyclical abdominal pain, hematometra and complete vaginal agenesis. Surgical correction is the mainstay of treatment in patients with functioning uterus and absent vagina. Vaginoplasty was done to reconstruct a neovagina using amnion graft and establish uterovaginal continuity. In this case we have used only perineal approach to dissect the neovagina and identify the cervix with formation of a patent drainage tract and adequate vaginal length of 9 cm. Conclusion: In rare cases of obstructed functioning uterus by complete vaginal agenesis, vaginoplasty effectively restores anatomy and function by an overall minimal operative morbidity. Human amnion provides excellent results in neovaginal reconstruction.

Krishna Dahiya; Ranjita Bains

2011-01-01

375

Hematometra as a cause of lumbar radiculopathy. A case report.  

UK PubMed Central (United Kingdom)

Low-back pain combined with a positive straight leg raising test (Lasègue's sign) is uncommon in children and adolescents. Reproductive tract (Mullerian) anomalies causing an accumulation of menstrual blood in the vagina, uterus, and fallopian tubes represent an unusual extraspinal cause of low-back pain. The accumulation of blood in these cavities is termed hematocolpos, hematometra, and hematosalpinx. Amenorrhea with cyclic lower abdominal pain and a presenting pelvic mass are the usual presenting features. In the current report, we describe a case of an adolescent with low-back pain, positive straight leg raising test, and signs of L5 radiculopathy that were attributable to hematometra secondary to congenital partial absence of a vagina. This appears to be the first report of this type of presentation.

Deathe AB

1993-10-01

376

An intervention to decrease intravaginal practices in hiv-infected women in Zambia: a pilot study.  

UK PubMed Central (United Kingdom)

Intravaginal practices (IVP) are those in which women introduce products inside the vagina for hygienic, health, or sexuality reasons. IVP are associated with bacterial vaginosis (BV) and potentially implicated in HIV transmission. This report presents the results of a pilot study of a behavioral intervention to decrease IVP in HIV-infected women in Zambia. At baseline, all of the enrolled women (n =40) engaged in IVP and rates of BV were high. Women receiving the intervention reported a decrease of the insertion of water and cloths inside the vagina. Communication with sexual partners regarding IVP was higher for women receiving the intervention. Results from this study suggest that a behavioral intervention could decrease IVP in HIV-infected women in Zambia and this may have an impact in decreasing HIV transmission from women to sexual partners and newborns.

Alcaide ML; Mumbi M; Chitalu N; Jones DL

2013-05-01

377

Altered CD16 expression on vaginal neutrophils from women with vaginitis.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Reduced CD16 expression is associated with neutrophil apoptosis. This study aimed to compare CD16 expression on neutrophils in the vagina from women with normal bacterial flora and with vaginitis. STUDY DESIGN: Vaginal lavages were sampled from volunteers diagnosed with bacterial vaginosis (BV, n=34), vulvovaginal candidiasis (VC, n=43), BV plus VC (BV+VC, n=14), and normal flora (NF, n=51). Neutrophils were identified by expression of CD15, CD16 and CD24 surface markers as assessed by flow cytometry. RESULTS: CD16 expression was elevated in neutrophils from women with vaginitis (BV p<0.0001; VC p=0.01; BV+VC p=0.0027) as compared to women with NF. CONCLUSION: The reduction in CD16 down-regulation is consistent with prolonged neutrophil viability and activity in the vagina of women with vaginitis. This may contribute to greater microbial clearance and, conversely, with inflammation-associated pathology.

Beghini J; Giraldo PC; Riboldi R; Amaral RL; Eleutério J Jr; Witkin SS; Guimarães F

2013-03-01

378

 

Directory of Open Access Journals (Sweden)

Full Text Available A study of 404 women that attended the Microbiology Laboratory of "Ramón Gonzalez Coro" Gynecoobstetric Hospital, in Havana City, was conducted aimed at identifying species of yeasts isolated from Pap smears, registering the signs and clinical symptoms and determining the risk factors associated with infection. The isolated yeasts were identified by the filamentation tests in serum, production of chlamydoconidia and carbohydrate assimilation. It was found that 138 (34.16 %) of women had yeasts in the vagina. 3 genera were identified: Candida (88.49 %). Trichosporon (10.79 %) and Rhodotorula (0.72 %). Pruritus and heat showed statistical significance (p<0.01). Pregnancy, the use of IUD and the antibacterial therapy proved to be the most common risk factors in relation to the presence of Candida in the vagina.

2004-01-01

379

Condiloma gigante y embarazo Giant condyloma and pregnancy  

Directory of Open Access Journals (Sweden)

Full Text Available Se presenta una paciente con un condiloma acuminado gigante (tumor de Bushke-Lowenstein) durante el embarazo. El considerable crecimiento de esta condiloma en la región anoperineal con propagación a la vulva, obstruyó completamente la vagina e imposibilitó el acceso para el examen ginecológico. La enfermedad requirió que la vía del parto fuera mediante cesárea para prevenir la posible infección neonatal en el recién nacido. La lesión se trató quirúrgicamente después del puerperio y evolucionó satisfactoriamente y sin recidivas.A patient with a giant condyloma acuminatum (Bushke-Lowenstein's tumor) during pregnancy is presented. The considerable growth of this condyloma in the anoperineal region with spreading to the vulva produced a complete obstruction of the vagina and made impossible the access to the gynecological examination. The disease required cesarean section to prevent a possible neonatal infection in the newborn infant. The injury was surgically treated after puerperium and it evolved satisfactorily and without relapses.

Nayma Gutiérrez González; Bárbara Enríquez Domínguez; Ángel Luis Villar Novell

2003-01-01

380

TABIQUE VAGINAL TRANSVERSO Y ATRESIA VAGINAL  

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Full Text Available El tabique vaginal transverso, la atresia vaginal parcial y la atresia vaginal total, son una gama de alteraciones congénitas, en las que se ve afectada la continuidad de la vagina. En conjunto, son malformaciones poco frecuentes del aparato genital. A continuación exponemos la experiencia de nuestro servicio respecto a esta patología, durante 13 años(1989 a 2002), presentando 4 casos clínicos y un análisis del tema basado en la literaturaTransverse vaginal septum, partial vaginal atresia and complete vaginal atresia, are a group of congenital malformations, in which there is an alteration in vaginal continuity. Together they rare congenital malformations of the vagina. We present our departament experience of this pathology during 13 yers (1989 to 2002). We report 4 cases and a review of the literature

Paola Bustos; Marcia Smirnow

2003-01-01

 
 
 
 
381

Isolated fetal ascites secondary to persistent urogenital sinus.  

UK PubMed Central (United Kingdom)

Objective. To present a case of isolated ascites secondary due to urogenital abnormalities (urogenital sinus) without any other prenatal ultrasound marker. Method. A 36-year-old woman with prenatal isolated ascites delivered a female baby, weighing 2.285 g; ascites was drained at birth and the baby underwent several episodes of urinary retention prior to undergoing X-ray investigations. Results. A voiding cystourethrogram revealed a short urogenital sinus: a vesicostomy was performed. A vaginoscopy revealed double vagina with a large posterior vagina. A posterior sagittal anorectal pull-through with genitoplasty was performed at 2 years old with 1-year follow-up. Conclusions. Though rare, a urogenital abnormality is to be suspected in fetal ascites cases with negative viral tests and no cardiac anomalies. The most common ultrasound marker of such abnormalities (fluid filled cavity) may be missing because of complete drainage of urine through the tubes into peritoneum.

Camanni D; Zaccara A; Capitanucci ML; Mosiello G; Capolupo I; Iacobelli BD; De Gennaro M

2009-01-01

382

Isolated fetal ascites secondary to persistent urogenital sinus.  

Science.gov (United States)

Objective. To present a case of isolated ascites secondary due to urogenital abnormalities (urogenital sinus) without any other prenatal ultrasound marker. Method. A 36-year-old woman with prenatal isolated ascites delivered a female baby, weighing 2.285 g; ascites was drained at birth and the baby underwent several episodes of urinary retention prior to undergoing X-ray investigations. Results. A voiding cystourethrogram revealed a short urogenital sinus: a vesicostomy was performed. A vaginoscopy revealed double vagina with a large posterior vagina. A posterior sagittal anorectal pull-through with genitoplasty was performed at 2 years old with 1-year follow-up. Conclusions. Though rare, a urogenital abnormality is to be suspected in fetal ascites cases with negative viral tests and no cardiac anomalies. The most common ultrasound marker of such abnormalities (fluid filled cavity) may be missing because of complete drainage of urine through the tubes into peritoneum. PMID:19936120

Camanni, D; Zaccara, A; Capitanucci, M L; Mosiello, G; Capolupo, I; Iacobelli, B D; De Gennaro, M

2009-02-15

383

[The characteristic of biocenosis of urogenital tract in women].  

Science.gov (United States)

The article deals with the study of characteristics of biocenosis of urogenital tract in women of reproductive age with using of "Femoflor" test. The scrapings of posterolateral wall of vagina were analyzed using the technique of real-time polymerase chain reaction using the reagents "Femoflor". The complex evaluation of urogenital biota identified three main types of biocenosis of vagina: type I--normocenosis (n = 50 or 11.5%): type II--mild dysbiosis (n = 88 or 21%); type III--marked dysbiosis (n = 133 or 30.6%). In the structure of alterations of biocenosis of urogenital tract the main role play the anaerobic bacteria with involvement of candida, ureoplasma and mcoplasma. PMID:23807998

Andosova, L D; Kontorshchikova, K N; Kachalina, O V; Belov, A V; Gonova, E S; Kudel'kina, S Iu

2013-01-01

384

[The characteristic of biocenosis of urogenital tract in women].  

UK PubMed Central (United Kingdom)

The article deals with the study of characteristics of biocenosis of urogenital tract in women of reproductive age with using of "Femoflor" test. The scrapings of posterolateral wall of vagina were analyzed using the technique of real-time polymerase chain reaction using the reagents "Femoflor". The complex evaluation of urogenital biota identified three main types of biocenosis of vagina: type I--normocenosis (n = 50 or 11.5%): type II--mild dysbiosis (n = 88 or 21%); type III--marked dysbiosis (n = 133 or 30.6%). In the structure of alterations of biocenosis of urogenital tract the main role play the anaerobic bacteria with involvement of candida, ureoplasma and mcoplasma.

Andosova LD; Kontorshchikova KN; Kachalina OV; Belov AV; Gonova ES; Kudel'kina SIu

2013-01-01

385

Mayer-Rokitansky-Kuster-Hauser syndrome: a review of 245 consecutive cases managed by a multidisciplinary approach with vaginal dilators.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To understand the efficacy of vaginal dilators in the management of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. DESIGN: Retrospective sequential study. SETTING: Hospital. PATIENT(S): 245 women. INTERVENTION(S): Vaginal dilators. MAIN OUTCOME MEASURE(S): Functional vaginal length and sexual satisfaction. RESULT(S): Of the patients who completed the program, 232 (94.9%) achieved a successful vaginal length (defined as greater than 6 cm in length and maximum width throughout the vagina and especially at the apex) and sexual function. When the program was completed by all patients, 100% of patients were successful. CONCLUSION(S): Vaginal dilator therapy is the treatment of first choice for creation of the vagina in MRKH syndrome, and the success rates suggest that surgery is rarely, if ever, required.

Edmonds DK; Rose GL; Lipton MG; Quek J

2012-03-01

386

Mayer-Rokitansky-Kuster-Hauser Syndrome with hyperprolactinemia  

International Nuclear Information System (INIS)

[en] Mayer-Rokitansky-Kuster-Hauser Syndrome in association with hyperprolactinemia is very rare. An 18-year-old Saudi single, virgin female was accompanied by her mother seeking medical advice regarding absent menses. She had normal breasts, normal axillary and pubic hair, normal vulva, urethra and labial folds, however, the vagina was blind, approximately 2 cm length. Pelvic magnetic resonance imaging showed normal appearing ovaries, a small uterus and small cervix and vagina. Investigations showed initial high serum prolactin of 1,517mIU/L. Cranial MRI was normal. The patient was diagnosed as mullerian hypoplasia class I American Fertility Society. After an extensive literature search, we present a unique case of concomitant occurrence of MRKH, in the form of mullerian hypoplasia and hyperprolactinemia. (author)

2008-01-01

387

Total urogenital mobilization by posterior sagittal approach and ileal neovaginoplasty in cloacal repair by a common channel of 4 cm.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The total urogenital mobilization (TUM) technique avoids dissection of the vagina from the urinary tract. However, in the case of a long common channel, bowel interposition for vaginal replacement may be necessary. We present a video of the TUM technique in cloacal repair with ileal neovaginoplasty. METHODS: An 8-month-old female patient with cloaca, presenting a 4-cm common channel, was operated on by the TUM technique, through a perineal sagittal with additional abdominal approach. She had undergone decompressing colostomy at birth. Total urogenital sinus mobilization was performed with ileal neovaginoplasty. RESULTS: The patient had a good postoperative outcome, an endoscopy of all structures reconstructed was performed at PO day 30, and home dilatation of colon and vagina by parents was initiated. CONCLUSION: TUM with neovaginoplasty bowel interposition is an effective technique for repairing long common channels.

Macedo A Jr; Rondon A; Frank R; Leslie B; Bacelar H; Ottoni S; Ortiz V

2013-10-01

388

Real-time three-dimensional ultrasound visualization of erection and artificial coitus.  

UK PubMed Central (United Kingdom)

To investigate the feasibility of imaging penile erection and coitus in real time and in three dimensions, a 'Live' three-dimensional (3-D) ultrasound system was used to acquire the volume of interest at 25 Hz from five healthy men. Water baths and gel-made artificial vaginas were devised to facilitate the 3-D scans without the probe being in direct contact with the penis. For the first volunteer scanned with the water bath alone, the penis failed to erect within 30 min. For the other four volunteers, the 'vagina' successfully initiated and maintained the erection and allowed artificial intercourse. Results have shown that the 'Live' 3-D ultrasound and minimally compressive imaging techniques together can offer an objective means for visualizing erection and coitus in spatial totality and temporal reality. They can be further developed to reveal more reliable details about the dynamic morphology, improving scientific understanding of sexual activities and clinical management of related problems.

Deng J; Hall-Craggs MA; Pellerin D; Linney AD; Lees WR; Rodeck CH; Todd-Pokropek A

2006-04-01

389

Carrier state of Pasteurella pneumotropica in mice and rats.  

UK PubMed Central (United Kingdom)

Localization of Pasteurella pneumotropica was investigated in the respiratory tract, conjunctiva and vagina of 5-week-old, 10-week-old and retired asymptomatic mice and rats. The highest isolation rate of the organisms was obtained in the pharyngolarynx, showing 85 to 97.5% in carrier mice and 100% in carrier rats. Numbers of the organisms in this site were 10(3-5) and 10(7-8) organisms/g tissue in 4-week-old mice and rats, respectively. Isolation rates in the nasal cavity and trachea of the both animals were not so high as those in the pharyngolarynx, but usually higher than those in the external nares. The organisms were rarely isolated from the lung. Isolation of the organisms from the conjunctiva was common in rats, especially in young ones, but rare in mice. About 30% of carrier mice and 50 to 100% of carrier rats harbored the organisms in their vaginas.

Saito M; Kohjima K; Sano J; Nakayama K; Nakagawa M

1981-07-01

390

An intervention to decrease intravaginal practices in hiv-infected women in Zambia: a pilot study.  

Science.gov (United States)

Intravaginal practices (IVP) are those in which women introduce products inside the vagina for hygienic, health, or sexuality reasons. IVP are associated with bacterial vaginosis (BV) and potentially implicated in HIV transmission. This report presents the results of a pilot study of a behavioral intervention to decrease IVP in HIV-infected women in Zambia. At baseline, all of the enrolled women (n =40) engaged in IVP and rates of BV were high. Women receiving the intervention reported a decrease of the insertion of water and cloths inside the vagina. Communication with sexual partners regarding IVP was higher for women receiving the intervention. Results from this study suggest that a behavioral intervention could decrease IVP in HIV-infected women in Zambia and this may have an impact in decreasing HIV transmission from women to sexual partners and newborns. PMID:23340240

Alcaide, Maria L; Mumbi, Miriam; Chitalu, Ndashi; Jones, Deborah L

2013-01-20

391

The effect of Lacto- and Bifidobacteria in monoculture on the vaginal microflora in norm and in cases of intravaginal staphylococcosis.  

Science.gov (United States)

The influence of probiotic strains of Lactobacillus casei IMV B-7280, Lactobacillus acidophilus IMV B-7279, Bifidobacterium animalis VKL, Lactobacillus delbrueckii subsp. bulgaricus IMV B-7281 and Bifidobacterium animalis VKB, each strain separately, to the range of the urogenital tract microflora in physiological norm and in cases of experimental intravaginal staphylococcosis of mice induced by Staphylococcus aureus 8325-4. It was found that all these strains had different efficiency in Staphylococcus aureus 8325-4 growth suppression in the vagina of infected mice and affect the spectrum of microorganisms. Lactobacillus casei IMV B-7280 strain had effective antistaphylococcal effect and reduced the number of coliform bacteria and fungi in the vagina in cases of intravaginal staphylococcosis of mice. Lactobacillus casei IMV B-7280 strain is promising to create probiotic drugs effective in treating intravaginal staphylococcosis. PMID:23866586

Babenko, L R; Lazarenko, L M; Shynkarenko, L M; Mokrozub, V V; Pidgorskyi, V S; Spivak, M Ja

392

The effect of Lacto- and Bifidobacteria in monoculture on the vaginal microflora in norm and in cases of intravaginal staphylococcosis.  

UK PubMed Central (United Kingdom)

The influence of probiotic strains of Lactobacillus casei IMV B-7280, Lactobacillus acidophilus IMV B-7279, Bifidobacterium animalis VKL, Lactobacillus delbrueckii subsp. bulgaricus IMV B-7281 and Bifidobacterium animalis VKB, each strain separately, to the range of the urogenital tract microflora in physiological norm and in cases of experimental intravaginal staphylococcosis of mice induced by Staphylococcus aureus 8325-4. It was found that all these strains had different efficiency in Staphylococcus aureus 8325-4 growth suppression in the vagina of infected mice and affect the spectrum of microorganisms. Lactobacillus casei IMV B-7280 strain had effective antistaphylococcal effect and reduced the number of coliform bacteria and fungi in the vagina in cases of intravaginal staphylococcosis of mice. Lactobacillus casei IMV B-7280 strain is promising to create probiotic drugs effective in treating intravaginal staphylococcosis.

Babenko LR; Lazarenko LM; Shynkarenko LM; Mokrozub VV; Pidgorskyi VS; Spivak MJ

2013-05-01

393

Natural orifice transluminal endoscopic surgery: The transvaginal route moving forward from cholecystectomy  

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Full Text Available The advent of minimally invasive surgery and the advances in endoluminal flexible endoscopy have converged to generate a new concept in digestive surgery, whose acronym natural orifice transluminal endoscopic surgery (NOTES), has become a familiar term in the surgical community. NOTES has been performed through the mouth, the bladder, the rectum and the vagina. Of these four approaches, the vagina has gained most popularity for several reasons. It is not only readily accessible and easy to decontaminate but it also provides safe entry and simple closure. The transvaginal approach has been described in the experimental and the clinical setting as an option for cholecystectomy, nephrectomy, splenectomy, segmental gastrectomy, retroperitoneal exploration and bariatric surgery. However, larger series are needed to delineate the exact risks of this approach, and to transcend cultural barriers that impede its wider introduction. Prospective randomized trials will shed light on the definitive role of the vaginal approach in minimal invasive surgery of the future.

Eduardo M Targarona; Edgar Mauricio Maldonado; Jose Antonio Marzol; Franco Marinello

2010-01-01

394

A rare case of vaginal vault evisceration and its management.  

UK PubMed Central (United Kingdom)

A 66 year old woman presented to A&E with per vagina bleeding and a mass protruding from the vagina. The patient was examined under anaesthesia, which revealed vaginal prolapse with evisceration of approximately 20-30 cm of bowel. The patient had received an abdominal hysterectomy 30 years ago for menorrhagia. In the last decade, the patient had experienced other recurrent episodes of prolapse (cystocoele and retrocoele). Vaginal vault evisceration is a recognised rare complication of hysterectomy and is a gynaecological emergency. This patient’s condition was rapidly recognised and surgically managed. The repair was achieved in two surgeries. Initially, the small bowel was re-inserted into the peritoneal cavity through the vaginal wall defect and the vaginal defect repaired. After sufficient time for healing, a sacrocolpopexy was performed to repair the prolapse.

Pereira FA; Rai H

2012-05-01

395

Comparison of incident cervical and vulvar/vaginal human papillomavirus infections in newly sexually active young women.  

Science.gov (United States)

Vulvar/vaginal human papillomavirus (HPV) infections may precede cervical infections, and certain low-risk types may display vaginal tropism. We evaluated whether incident infections in young women display site-specific preferences by HPV risk group or phylogenetic species. Although incident infections were more likely to be detected in the vulva/vagina than in the cervix (odds ratio, 4.38 [95% confidence interval, 2.51-7.63]), the majority were first detected at both sites. Low- or undetermined-risk types were more likely than high-risk types to be first detected in the vulva/vagina (P = .03). Site-by-species differences were not statistically significant. Our results suggest that low- or undetermined-risk HPV types preferentially infect vaginal epithelium. PMID:19434913

Winer, Rachel L; Hughes, James P; Feng, Qinghua; O'Reilly, Sandra; Kiviat, Nancy B; Koutsky, Laura A

2009-03-15

396

Comparison of incident cervical and vulvar/vaginal human papillomavirus infections in newly sexually active young women.  

UK PubMed Central (United Kingdom)

Vulvar/vaginal human papillomavirus (HPV) infections may precede cervical infections, and certain low-risk types may display vaginal tropism. We evaluated whether incident infections in young women display site-specific preferences by HPV risk group or phylogenetic species. Although incident infections were more likely to be detected in the vulva/vagina than in the cervix (odds ratio, 4.38 [95% confidence interval, 2.51-7.63]), the majority were first detected at both sites. Low- or undetermined-risk types were more likely than high-risk types to be first detected in the vulva/vagina (P = .03). Site-by-species differences were not statistically significant. Our results suggest that low- or undetermined-risk HPV types preferentially infect vaginal epithelium.

Winer RL; Hughes JP; Feng Q; O'Reilly S; Kiviat NB; Koutsky LA

2009-03-01

397

[The microorganisms associated with bacterial vaginosis as a cause of tubal sterility  

UK PubMed Central (United Kingdom)

Bacterial vaginosis is one of the most widespread disturbances of the normal state of the vagina of women of reproductive and menopausal age. This condition is highly disregarded due to its moderate and not always clear clinical manifestation. The disturbed proportion of microorganisms in vagina is shown in the strong decrease or lack of lactobacilli and a spread of associated with bacterial vaginosis microorganisms. G. vaginalis, Mobiluncis spp., Bacteroides spp. (without B. fragilis), Peptostreptococcus spp., Mycoplasma hominis, Ureaplasma urealyticum. The condition is a predisposition to a disturbance of natural defense mechanisms and to a spread of infectious agents towards the upper female genital tract. This is a predisposition for the development of tubal patency and motility disorders, ovarian function disturbances, endometrites. The treatment of this condition as an important step in female sterility prophylaxis is commented.

Andreeva P; Dimitrov A

2002-01-01

398

Complete imperforate tranverse vaginal septum with septate uterus: A rare anomaly.  

Science.gov (United States)

The isolated, complete, transverse vaginal septum is one of the most infrequent anomalies of the female genital tract, and when it coexists with a septate uterus, it is even rarer. This report describes a case of transverse vaginal septum with septate uterus. A 12-year-old girl sought medical assessment because of severe cyclic lower abdominal cramping and pelvic pain. Local examination revealed a blind vaginal pouch of 2 cm and on rectal examination a tender pelvic mass was noted. Radiological examination showed transverse vaginal septum in the lower vagina with bicornuate uterus. Surgical resection of the vaginal septum was done under laparoscopic guidance. Hysteroscopy revealed presence of uterine septum which was resected by a resectoscope. Post-operative dilatation of vagina was done to prevent restenosis. Laparoscopic guided abdominoperineal approach is better in such a case as multiple mullerian anomalies may coexist with each other. PMID:23869157

Jain, Nutan; Gupta, Anjali; Kumar, Ravindra; Minj, Agnes

2013-01-01

399

Sawadalepis prima n. g., n. sp. (Cestoda: Cyclophyllidea) from the Schreiber's bent-winged bat Miniopterus schreibersii Kuhl (Chiroptera: Vespertilionidae) from China.  

UK PubMed Central (United Kingdom)

Sawadalepis n. g. is erected for Sawadalepis prima n. sp. in Schreiber's bent-winged bat Miniopterus schreibersii Kuhl (Chiroptera: Vespertilionidae) from southern China. Diagnostic features of the currently monotypic genus include attributes of the osmoregulatory system and female genital organs. The dorsal osmoregulatory canals are shifted bilaterally towards the margins of proglottides in relation to the ventral canals. The genital pores are unilateral and sinistral. Among female attributes, the copulatory part of the vagina is covered externally by a dense layer of intensely stained cells; the conductive part of the vagina is clearly distinguishable from the seminal receptacle; the uterus has ventral and dorsal diverticula, extending bilaterally beyond the longitudinal osmoregulatory canals; and the eggs are spherical with thick outer coat.

Makarikova TA; Makarikov AA

2013-09-01

400

Large vesico-vaginal fistula caused by a foreign body.  

UK PubMed Central (United Kingdom)

Foreign body is a rare cause of vesico-vaginal fistula most often reported in developed countries. In developing countries obstructed labor is the commonest cause of fistula. A nulliparous 19-year-old female presented with a 3-week history of a foreign body in the vagina causing urinary incontinence and offensive vaginal discharge. Her guardian allegedly inserted the foreign body after she refused a pre-arranged marriage. A plastic container was removed from the vagina under general anesthesia. A large vesico-vaginal fistula was discovered, which was successfully surgically repaired. We recommend urgent removal of the foreign body, preferably under general anesthesia. However, if the history or physical examination reveals prolonged exposure, repair of the fistula should be delayed to allow for adequate debridement in order to prevent any life-threatening complications.

Massinde A; Kihunrwa A

2013-07-01

 
 
 
 
401

AIDS-related Kaposi sarcoma: findings on thallium-201 scintigraphy  

International Nuclear Information System (INIS)

No simple, noninvasive method is available for evaluating extracutaneous Kaposi sarcoma in AIDS patients or for following the tumor's response to treatment. We report our preliminary experience with thallium-201 scintigraphy in nine AIDS patients with proved Kaposi sarcoma. Eight of the nine had abnormal uptake of the radionuclide in skin, lymph nodes, oral cavity, vagina, and lungs. Only four of the nine had cutaneous Kaposi sarcoma at the time of scanning. All cutaneous and mucosal lesions were thallium avid. Two of the six patients with thallium-avid nodes underwent nodal biopsy. Both biopsies confirmed the diagnosis of Kaposi sarcoma. Cutaneous Kaposi sarcoma developed later in one of these patients, showing the efficacy of thallium scintigraphy for the early detection of extracutaneous lesions. These preliminary results show thallium avidity in Kaposi sarcoma involving the skin and various extracutaneous sites (lymph nodes, lung, mucosa, and vagina). Thallium scintigraphy is a potentially useful procedure for detecting extracutaneous Kaposi sarcoma in AIDS patients.

1988-01-01

402

Amputação abdômino-perineal mais colostomia para-vaginal no tratamento do câncer reto-anal Abdomino-perineal amputation plus para-vaginal colostomy in the treatment of reto-anal cancer  

Directory of Open Access Journals (Sweden)

Full Text Available O apresenta uma proposta e as tentativas iniciais para evitar a colostomia abdominal quando esta tem que ser definitiva. Na mulher foi possível a sua execução, desde que se aproveitou o tono da musculatura esfincteral vulvovaginal quando ela pode ser preservada na amputação de reto-ânus. O colo, preparado com as válvulas, desce posteriormente à vagina, por dentro do conjunto esfincteral vulvovaginal. As observações iniciais mostram que esta tentativa poderia ser incrementada para melhores estudos de continência.The Author presents a proposal and lhe initial attempties to avoid the abdominal colostomy when it has to be definitive. In the woman was possible its execution, since it took advantage from the vulvovaginal esfincteral muscle nohen it can be preserved ot the anus-rectum amputation. The colon, prepared wit the valves, descend posteriorily from the vagina, inside the vulvo-vaginal esfincteral group. The initial observations shows that this attempt could be better developed for cotinency etudies.

Alcino Lázaro da Silva

2009-01-01

403

Didelphic uterus and obstructed hemivagina: recurrent hematometra in spite of appropriate classic surgical treatment.  

Science.gov (United States)

We report the case of a young girl with uterus didelphys, obstructed vagina and ipsilateral renal agenesis treated by diagnostic laparoscopy and resection of the vaginal septum by a vaginal approach in order to drain the distended uterus. Despite classic surgery, the myometrium on the treated side never recovered its normal function, with subsequent persistence of recurrent hematometra. Laparoscopic subtotal hemihysterectomy had to be performed to avoid retention of hematometra and secondary pelvic inflammatory disease. PMID:17016051

Donnez, Olivier; Jadoul, Pascale; Squifflet, Jean; Donnez, Jacques

2006-10-02

404

Didelphic uterus and obstructed hemivagina: recurrent hematometra in spite of appropriate classic surgical treatment.  

UK PubMed Central (United Kingdom)

We report the case of a young girl with uterus didelphys, obstructed vagina and ipsilateral renal agenesis treated by diagnostic laparoscopy and resection of the vaginal septum by a vaginal approach in order to drain the distended uterus. Despite classic surgery, the myometrium on the treated side never recovered its normal function, with subsequent persistence of recurrent hematometra. Laparoscopic subtotal hemihysterectomy had to be performed to avoid retention of hematometra and secondary pelvic inflammatory disease.

Donnez O; Jadoul P; Squifflet J; Donnez J

2007-01-01

405

Composition of the Vaginal Microbiota in Women of Reproductive Age - Sensitive and Specific Molecular Diagnosis of Bacterial Vaginosis Is Possible?  

Science.gov (United States)

Background and Objective Bacterial vaginosis (BV) is the most common vaginal disorder, characterized by depletion of the normal lactobacillus-dominant microbiota and overgrowth of commensal anaerobic bacteria. This study aimed to investigate the composition of the vaginal microbiota in women of reproductive age (healthy women and women with BV), with the view of developing molecular criteria for BV diagnosis. Materials and Methods Vaginal samples from 163 women (79 control, 73 BV and 11 intermediate (Lactobacillary grade II flora) cases) were analyzed using 454 pyrosequencing of the hypervariable regions V3–V4 of the 16S rRNA gene and 16 quantitative bacterial species/genus-specific real-time PCR assays. Sensitivities and specificities of potential BV markers were computed using the Amsel criteria as reference standard for BV. The use of quantitative thresholds for prediction of BV, determined for both relative abundance measured with 454 pyrosequencing and bacterial load measured with qPCR, was evaluated. Results Relative to the healthy women, the BV patients had in their vaginal microbiota significantly higher prevalence, loads and relative abundances of the majority of BV associated bacteria. However, only Gardnerella vaginalis, Atopobium vaginae, Eggerthella, Prevotella, BVAB2 and Megasphaera type 1 detected at or above optimal thresholds were highly predictable for BV, with the best diagnostic accuracy shown for A. vaginae. The depletion of Lactobacillus species combined with the presence of either G. vaginalis or A. vaginae at diagnostic levels was a highly accurate BV predictor. Conclusions Quantitative determination of the presence of G. vaginalis, A. vaginae, Eggerthella, Prevotella, BVAB2 and Megasphaera type 1 as well as the depletion of Lactobacillus was highly accurate for BV diagnosis. Measurements of abundance of normal and BV microbiota relative to total bacteria in vaginal fluid may provide more accurate BV diagnosis, and be used for test-of-cure, rather than qualitative detection or absolute counts of BV related microorganisms.

Shipitsyna, Elena; Roos, Annika; Datcu, Raluca; Hallen, Anders; Fredlund, Hans; Jensen, J?rgen S.; Engstrand, Lars; Unemo, Magnus

2013-01-01

406

Placenta accrete treated with uterine arterial embolization (case report)  

International Nuclear Information System (INIS)

[en] Objective: To investigate the possibility of interventional treatment of placenta accrete. Methods: One patient with placenta accrete was treated with uterine arterial infusion of cef and MTX followed by embolization. Results: Her placenta discharged through vagina at the 27 th day after uterine arterial embolization. No remnant was found in the uterine by Doppler imaging. The patient uneventfully recovered. Conclusions: Interventional therapy with uterine arterial embolization is a new and reliable method for treatment for placenta accrete

2002-01-01

407

Uterus didelphys with partial vaginal septum and distal vaginal agenesis: an unusual anomaly.  

UK PubMed Central (United Kingdom)

Complex malformations of female genital tract are not so common. Their correct identification is of paramount importance for appropriate management. A thorough knowledge of embryology, pre-operative imaging with MRI and examination under anaesthesia is essential to identify accurately the constellation of anomalies and to plan appropriate management. This case reports the coexistence of Müllerian abnormality with vaginal agenesis in an 18 years old girl which was managed by dissecting the lower half of vagina and pull-through vaginoplasty.

Singhal SR; Lakra P; Bishnoi P; Rohilla S; Dahiya P; Nanda S

2013-02-01

408

Dynamic article: Vaginal and perineal reconstruction using rectus abdominis myocutaneous flap in surgery for locally advanced rectum carcinoma and locally recurrent rectum carcinoma.  

UK PubMed Central (United Kingdom)

BACKGROUND: Surgery for locally advanced and recurrent rectal carcinoma sometimes requires partial resection of the perineum and/or vagina necessitating subsequent reconstruction. OBJECTIVE: The aim of this study was to describe the surgical and functional outcomes of reconstructing the vagina and/or the perineum by using the vertical rectus abdominis myocutaneous flap and to evaluate the health status of patients who received reconstruction. DESIGN: This is a retrospective cohort study. SETTINGS: This study was conducted at a tertiary referral hospital for locally advanced and recurrent rectal cancer. PATIENTS: Patients receiving multimodality treatment for primary or recurrent locally advanced rectal carcinomas were included. MAIN OUTCOME MEASURES: First, the surgical outcome was assessed. Second, 10 female patients who received vaginal reconstruction underwent a gynecological examination including biopsies. Finally, quality of life was assessed and compared with patients who underwent treatment for rectal carcinoma without a reconstruction. RESULTS: Fifty-one patients underwent reconstruction of the dorsal vagina and/or the perineum with the use of a vertical rectus abdominis myocutaneous flap. In 13 patients, the flap was used to close a perineal defect; in 26 patients, to close a vaginal defect; and in 12 patients, to close both. In 3 patients, partial necrosis of the flap occurred that was treated conservatively. In 4 patients, stenosis of the introitus occurred, as found in the gynecological examination. Biopsies confirmed epithelialization of the vaginal wall. All groups reported good functioning and low symptom burden. After vaginal reconstruction, women reported equal or higher scores on global health status, emotional functioning, and body image. LIMITATIONS: The lack of information on the health status of the patients before the start of treatment prohibits making causal inferences in health status over time. DISCUSSION: Reconstruction of the perineum and/or dorsal vagina was successful in all patients. Surgeons and gynecologists who use the vertical rectus abdominis myocutaneous flap should be aware of stenosis of the vaginal introitus. Gynecological consultation at an early stage should be standard.

Holman FA; Martijnse IS; Traa MJ; Boll D; Nieuwenhuijzen GA; de Hingh IH; Rutten HJ

2013-02-01

409

Apedunculata discoidea gen. n., sp. n. (Monogenea: Dactylogyridae) parasitic on Prochilodus lineatus (Valenciennes, 1837) (Characiformes: Prochilodontidae) from southeastern Brazil.  

UK PubMed Central (United Kingdom)

A new species of dactylogyrid monogenean, Apedunculata discoidea gen. n., sp. n. is described and illustrated from the gills of the freshwater fish Prochilodus lineatus (Valenciennes, 1837) in pisciculture ponds from Pirassununga, São Paulo, Brazil. Diagnostic characters of the new genus and species are: 1) vagina dextrolateral slightly sclerotised, opening anteriorly at level of copulatory complex; 2) copulatory organ coiled with two counterclockwise rings; 3) Accessory piece distal and not articulated; 4) body disk-shaped, lacking a peduncle.

Cuglianna AM; Cordeiro NS; Luque JL

2009-08-01

410

Apedunculata discoidea gen. n., sp. n. (Monogenea: Dactylogyridae) parasitic on Prochilodus lineatus (Valenciennes, 1837) (Characiformes: Prochilodontidae) from southeastern Brazil.  

Science.gov (United States)

A new species of dactylogyrid monogenean, Apedunculata discoidea gen. n., sp. n. is described and illustrated from the gills of the freshwater fish Prochilodus lineatus (Valenciennes, 1837) in pisciculture ponds from Pirassununga, São Paulo, Brazil. Diagnostic characters of the new genus and species are: 1) vagina dextrolateral slightly sclerotised, opening anteriorly at level of copulatory complex; 2) copulatory organ coiled with two counterclockwise rings; 3) Accessory piece distal and not articulated; 4) body disk-shaped, lacking a peduncle. PMID:19802450

Cuglianna, A M; Cordeiro, N S; Luque, J L

2009-08-01

411

Rectal extrusion of the catheter and air ventriculography following bowel perforation in ventriculo-peritoneal shunt  

International Nuclear Information System (INIS)

[en] Ventriculo-peritoneal shunt is frequently carried out in infantile hydrocephalus. The peritoneal shunt has a lower morbidity than ventriculo-atrial shunt and severe complications are uncommon. Abdominal complications include intestinal perforation, shunt migration, inguinal hernia, cerebrospinal fluid pseudocysts and hollow viscus perforation. A few cases of catheter extrusion from the rectum, vagina, umbilicus and urethra have been described. We report a new case of intestinal perforation with rectal extrusion of the catheter associated with a ventriculogram. (orig.)

1985-01-01

412

Rectal extrusion of the catheter and air ventriculography following bowel perforation in ventriculo-peritoneal shunt  

Energy Technology Data Exchange (ETDEWEB)

Ventriculo-peritoneal shunt is frequently carried out in infantile hydrocephalus. The peritoneal shunt has a lower morbidity than ventriculo-atrial shunt and severe complications are uncommon. Abdominal complications include intestinal perforation, shunt migration, inguinal hernia, cerebrospinal fluid pseudocysts and hollow viscus perforation. A few cases of catheter extrusion from the rectum, vagina, umbilicus and urethra have been described. We report a new case of intestinal perforation with rectal extrusion of the catheter associated with a ventriculogram.

Arico, M.; Podesta, A.F.; Bianchi, E.; Beluffi, G.; Fiori, P.; Chiari, G.; Pezzotta, S.

1985-01-01

413

Adenoma malignum of the uterine cervix--an enigma.  

Science.gov (United States)

Adenoma malignum is a rare variant of cervical adenocarcinoma which presents a great diagnostic and therapeutic challenge to an oncologist. A 31-year-old woman presented with a mass filling up whole of the vagina which showed no evidence of malignancy by scraping cytology or punch biopsy. But histological examination of the resected mass turned up to be adenoma malignum of the cervix. The patient was subsequently treated by Wertheim's hysterectomy and radiotherapy. PMID:23936961

Dasgupta, Subhankar; Aich, Ranen Kanti; Deb, Asit Ranjan; Gupta, Phalguni

2012-12-01

414

Adenoma malignum of the uterine cervix--an enigma.  

UK PubMed Central (United Kingdom)

Adenoma malignum is a rare variant of cervical adenocarcinoma which presents a great diagnostic and therapeutic challenge to an oncologist. A 31-year-old woman presented with a mass filling up whole of the vagina which showed no evidence of malignancy by scraping cytology or punch biopsy. But histological examination of the resected mass turned up to be adenoma malignum of the cervix. The patient was subsequently treated by Wertheim's hysterectomy and radiotherapy.

Dasgupta S; Aich RK; Deb AR; Gupta P

2012-12-01

415

Vaginal hemangiopericytoma: a histopathologic and ultrastructural evaluation.  

UK PubMed Central (United Kingdom)

The hemangiopericytoma is an uncommon stromovascular neoplasm that arises from the pericyte of Zimmerman. Since their original description in the female genital tract in 1954, the majority of these lesions have been of uterine origin. Presented is a clinicopathologic description of a hemangiopericytoma arising in the vagina and occupying the rectovaginal septum. Light and electron microscopic characterization is rendered. Current understanding of these lesions is reviewed and therapeutic options are discussed.

Buscema J; Rosenshein NB; Taqi F; Woodruff JD

1985-09-01

416

[Study of vaginal and intestinal microflora of women in the prenatal period and its correction in dysbacteriosis].  

Science.gov (United States)

A comparative research of the structure of vaginal and intestinal microflora in norm and at kidney pathologies in women in the prenatal period was carried out. At physiologically normal course of pregnancy microbiocenosis of vagina and intestine does not contain pathogenic and conditional-pathogenic microorganisms. Lactic acid bacteria are fixed within the limits of 10(5)-10(8) CFU/1 ml in the vagina secretion and 10(7)-10(8) CFU/1 g in the intestine content. The spore microorganisms have completely disappeared in vaginal biocenosis of women with pyelonephritis after pharmacotherapy; and colibacterias has disappeared in 62% of women. Quantity of lactic acid bacteria has also decreased. Quantity of E. coli (10(8)- 10(9)) CFU/g, sporous microorganisms (10(3)-10(4)) CFU/g and yeast (10(4)-10(5)) CFU/g has considerably increased in the content of intestine. Lactic acid bacteria in content of the vagina are presented by: Lactobacillus acidophilus, L. plantarum, L. fermentum, L. vaginalis; in content of the intestine--L. plantarum and L. fermentum. All the isolated strains of lactobacilli are resistant to metrogyl and amphotericin, 87%--to cephoxitine, cypropfloxacine. Twenty three of 24 strains of lactic acid bacteria--antagonists of pathogenic microflora have shown adhesion to vaginal epthelium. The degree of adhesive activity depends on the strain and genus specificity of cultures. The highest index of adhesiveness in indicated in Enterococcus faecium (5.82 - 7.62) and Streptococcus salivarius subsp. thermophilus (2.74 - 6.40) strains. The screening of strains has been performed, which suppress growth of gas-producing microflora. The strain of Lactobacillus plantarum 200D proved to be the most active one. A complex of cultures of the lactic bacteria providing normalization of microbial cenosis of the vagina in women in the prenatal period has been selected as based on the data obtained. The biotechnology of production of vaginal suppositories is developed. PMID:16786633

Podgorski?, V S; Liaskovski?, T M; Kovalenko, N K; Oleshchenko, L T

417

Malformations in a cohort of 284 women with Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH).  

UK PubMed Central (United Kingdom)

BACKGROUND: The aim of this retrospective study was to describe the spectrum of genital and associated malformations in women with Mayer-Rokitansky-Küster-Hauser syndrome using evaluated diagnostic procedures and the Vagina Cervix Uterus Adnex - associated Malformation classification system (VCUAM). METHODS: 290 women with MRKH syndrome were clinically evaluated with using clinical examinations, abdominal and perineal/rectal ultrasound, MRI, and laparoscopy. RESULTS: Classification of female genital malformation according to the Vagina Cervix Uterus Adnex - associated Malformation classification system was possible in 284 women (97.9%). Complete atresia of Vagina (V5b) and bilateral atresia of Cervix (C2b) were found in 284 patients (100%). Uterus: bilateral rudimentary or a plastic uterine horns were found in 239 women (84.2%). Adnexa: normal Adnexa were found in 248 women (87.3%). Malformations: associated malformations were found in 126 of 282 evaluable women (44.7%), 84 women (29.6%) had malformations of the renal system. Of 284 women with Mayer-Rokitansky-Küster-Hauser syndrome 212 women (74.7%) could be classified as V5bC2bU4bA0. The most frequent classification was V5bC2bU4bA0M0 (46.8%) diagnosed in 133 of 284 women. CONCLUSIONS: Complete atresia of vagina and cervix were found in all patients, variable malformations were found with uterus and adnexa. A variety of associated malformations were present, predominantly of the renal system. It is therefore recommended that all patients with genital malformations should be evaluated for renal abnormalities.

Oppelt PG; Lermann J; Strick R; Dittrich R; Strissel P; Rettig I; Schulze C; Renner SP; Beckmann MW; Brucker S; Rall K; Mueller A

2012-01-01

418

[Mayer-Rokitansky-Kuster-Hauser syndrome. A report of two cases].  

UK PubMed Central (United Kingdom)

The Mayer-Rokitansky-Kuster-Hauser is a rare congenital anomaly characterized by lack of vaginal and uterine development variable and normal ovaries. It results from agenesis or hypoplasia Müller duct system. Cervicovaginal agenesis as part of the complex syndrome, is even rarer. We report two cases: adolescent patient with primary amenorrhea, cervicovaginal agenesis and chronic pelvic pain, and a 28-year-old patient with primary amenorrhea, congenital absence of uterus and vagina.

Bautista-Gómez E; Morales-García V; Galván Espinosa H; Flores-Romero AL; Vásquez Santiago E; Pizarro Osorno N

2012-10-01

419

Glioblastoma arising in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome.  

UK PubMed Central (United Kingdom)

Mayer-Rokitansky-Küster-Hauser syndrome is a rare developmental disorder marked by the congenital absence of the uterus and vagina. The syndrome has been associated with tumors of the female reproductive system, but rarely in other organ systems and to our knowledge, never in the brain. We report a glioblastoma in a 34-year-old patient with Mayer-Rokitansky-Küster-Hauser syndrome.

Gonzalez EM; Prayson RA

2013-09-01

420

Malformations in a cohort of 284 women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH)  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The aim of this retrospective study was to describe the spectrum of genital and associated malformations in women with Mayer-Rokitansky-Küster-Hauser syndrome using evaluated diagnostic procedures and the Vagina Cervix Uterus Adnex – associated Malformation classification system (VCUAM). Methods 290 women with MRKH syndrome were clinically evaluated with using clinical examinations, abdominal and perineal/rectal ultrasound, MRI, and laparoscopy. Results Classification of female genital malformation according to the Vagina Cervix Uterus Adnex – associated Malformation classification system was possible in 284 women (97.9%). Complete atresia of Vagina (V5b) and bilateral atresia of Cervix (C2b) were found in 284 patients (100%). Uterus: bilateral rudimentary or a plastic uterine horns were found in 239 women (84.2%). Adnexa: normal Adnexa were found in 248 women (87.3%). Malformations: associated malformations were found in 126 of 282 evaluable women (44.7%), 84 women (29.6%) had malformations of the renal system. Of 284 women with Mayer-Rokitansky-Küster-Hauser syndrome 212 women (74.7%) could be classified as V5bC2bU4bA0. The most frequent classification was V5bC2bU4bA0M0 (46.8%) diagnosed in 133 of 284 women. Conclusions Complete atresia of vagina and cervix were found in all patients, variable malformations were found with uterus and adnexa. A variety of associated malformations were present, predominantly of the renal system. It is therefore recommended that all patients with genital malformations should be evaluated for renal abnormalities.

Oppelt Patricia G; Lermann Johannes; Strick Reiner; Dittrich Ralf; Strissel Pamela; Rettig Ingo; Schulze Christine; Renner Stefan P; Beckmann Matthias W; Brucker Sara; Rall Katharina; Mueller Andreas

2012-01-01

 
 
 
 
421

Malformations in a cohort of 284 women with Mayer-Rokitansky-K?ster-Hauser syndrome (MRKH)  

Science.gov (United States)

Background The aim of this retrospective study was to describe the spectrum of genital and associated malformations in women with Mayer-Rokitansky-Küster-Hauser syndrome using evaluated diagnostic procedures and the Vagina Cervix Uterus Adnex – associated Malformation classification system (VCUAM). Methods 290 women with MRKH syndrome were clinically evaluated with using clinical examinations, abdominal and perineal/rectal ultrasound, MRI, and laparoscopy. Results Classification of female genital malformation according to the Vagina Cervix Uterus Adnex – associated Malformation classification system was possible in 284 women (97.9%). Complete atresia of Vagina (V5b) and bilateral atresia of Cervix (C2b) were found in 284 patients (100%). Uterus: bilateral rudimentary or a plastic uterine horns were found in 239 women (84.2%). Adnexa: normal Adnexa were found in 248 women (87.3%). Malformations: associated malformations were found in 126 of 282 evaluable women (44.7%), 84 women (29.6%) had malformations of the renal system. Of 284 women with Mayer-Rokitansky-Küster-Hauser syndrome 212 women (74.7%) could be classified as V5bC2bU4bA0. The most frequent classification was V5bC2bU4bA0M0 (46.8%) diagnosed in 133 of 284 women. Conclusions Complete atresia of vagina and cervix were found in all patients, variable malformations were found with uterus and adnexa. A variety of associated malformations were present, predominantly of the renal system. It is therefore recommended that all patients with genital malformations should be evaluated for renal abnormalities.

2012-01-01

422

[Mayer-Rokitansky-Küster-Hauser syndrome. A report of two cases].  

Science.gov (United States)

The Mayer-Rokitansky-Kuster-Hauser is a rare congenital anomaly characterized by lack of vaginal and uterine development variable and normal ovaries. It results from agenesis or hypoplasia Müller duct system. Cervicovaginal agenesis as part of the complex syndrome, is even rarer. We report two cases: adolescent patient with primary amenorrhea, cervicovaginal agenesis and chronic pelvic pain, and a 28-year-old patient with primary amenorrhea, congenital absence of uterus and vagina. PMID:23240231

Bautista-Gómez, Esperanza; Morales-García, Víctor; Galván Espinosa, Honorio; Flores-Romero, Ana Luisa; Vásquez Santiago, Edmundo; Pizarro Osorno, Noel

2012-10-01

423

Complex Genital Malformation in a Female with Congenital Adrenal Hyperplasia: Evaluation with Magnetic Resonance Imaging  

International Nuclear Information System (INIS)

This is a case of complex genital malformation in a young patient with congenital adrenal hyperplasia. The magnetic resonance imaging (MRI) findings included ostium of the vagina into the urethra (common urogenital opening), prostate-like tissue surrounding the urethra, and hyperplasia of the left adrenal gland. The report provides information on the clinical findings, the MRI examination, including the applied sequences and the MR findings, and gives an overview of the disease pattern and its frequency of occurrence

2005-01-01

424

Villous adenoma: A rare tumor of vaginal vault  

Directory of Open Access Journals (Sweden)

Full Text Available Villous adenomas are extremely rare tumors in the vagina and are indistinguishable from their colonic counterparts. These are considered as enteric type neoplasms of lower female genital tract arising from cloacal remnants. The significance of this lesion lies in the fact that it has to be distinguished from metastatic adenocarcinoma from other sites. We present a case of villous adenoma of vaginal vault, a rare site of presentation in a 30-year-old female.

Shivaprakash H; Jayashree K; Girish M

2008-01-01

425

Ovarian radiation dose during dynamic cystourethrography using videorecording and photofluorography  

International Nuclear Information System (INIS)

[en] The ovarian radiation dose in dynamic cystourethrography was estimated by thermoluminescence dosimetry in a phantom and in 26 patients. The urodynamic examination technique was standardized and included fluoroscopy with videorecording and rapid sequence 100 mm fluorography. The examination was performed in the lateral position with dosimeters in the vagina, uterine cavity and rectum. The total dose in the midline was 13 mGy per examination, which compares with 12 mGy in urography. (orig.)

1986-01-01

426

La découverte de l'amour par Hidi Xinu. Récit caxinaua  

Directory of Open Access Journals (Sweden)

Full Text Available La littérature concernant la cosmologie caxinaua est assez connue, on propose néanmoins un récit jubilatoire qui raconte la découverte de l?amour par le personnage Xidi Xinu. Ce récit évoque le désespoir des Caxinaua qui prenaient le ?vagin? pour une méchante plaie. Malgré la connaissance de leur pharmacopée, ils n?arrivaient pas à la guérir. Cependant, un jour, l?un des Caxinaua, Hidi Xinu, a vu un couple de singes copuler et a compris la fonction du vagin : le réceptacle de l?amour, cutati. EL DESCUBRIMIENTO DEL AMOR POR HIDI SHINU. UNA NARRACIÓN CASHINAHUA. Aunque la literatura sobre la cosmología cashinahua es bastante conocida, proponemos aquí una alegre narración que cuenta el descubrimiento del amor por parte del personage Hidi Shinu. Esta narración evoca el desespero de los Cashinahua, quienes tomaban la vagina por una mala herida. A pesar de sus conocimientos farmacológicos, no lograban sanarla. Sin embargo, un día, uno de los Cashinahua vio copular a una pareja de micos y comprendió la función de la vagina: el receptáculo del amor, chutati. THE DISCOVERY OF LOVE BY HIDI SHINU. A CASHINAHUA TALE. The literature of the Cashinahua mythology is quite well known, thus I present an amusing tale about the discovery of love by the character Hidi Xinu. This tale reminds us of the despair of the Cashinahua who thought the vagina to be a very severe flesh wound. Regardless of their knowledge of pharmacopoeia, they could not heal her. However, one day, Hidi Xinu saw a couple of monkeys copulate and only then did he understand the function of the vagina: the chamber of love, chutati.

Camargo, Eliane

1999-01-01

427

Composition of the vaginal microbiota in women of reproductive age--sensitive and specific molecular diagnosis of bacterial vaginosis is possible?  

UK PubMed Central (United Kingdom)

BACKGROUND AND OBJECTIVE: Bacterial vaginosis (BV) is the most common vaginal disorder, characterized by depletion of the normal lactobacillus-dominant microbiota and overgrowth of commensal anaerobic bacteria. This study aimed to investigate the composition of the vaginal microbiota in women of reproductive age (healthy women and women with BV), with the view of developing molecular criteria for BV diagnosis. MATERIALS AND METHODS: Vaginal samples from 163 women (79 control, 73 BV and 11 intermediate (Lactobacillary grade II flora) cases) were analyzed using 454 pyrosequencing of the hypervariable regions V3-V4 of the 16S rRNA gene and 16 quantitative bacterial species/genus-specific real-time PCR assays. Sensitivities and specificities of potential BV markers were computed using the Amsel criteria as reference standard for BV. The use of quantitative thresholds for prediction of BV, determined for both relative abundance measured with 454 pyrosequencing and bacterial load measured with qPCR, was evaluated. RESULTS: Relative to the healthy women, the BV patients had in their vaginal microbiota significantly higher prevalence, loads and relative abundances of the majority of BV associated bacteria. However,