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Sample records for Vagina

  1. Vagina

    The vagina is the female body part that connects the womb (uterus) and cervix to the outside of the ... The vagina is a muscular tube lined with mucous membranes. Its opening is between the urethra (where urine leaves ...

  2. Vagina evaluation by MR imaging

    The author evaluated MR imaging of the vagina under different hormonal stimuli (25 patients) and assessed the role of MR imaging in the evaluation of congenital abnormalities (15 patients), primary (3) and metastatic (5) neoplasms, and reconstructive surgery (3). The findings were confirmed surgically. The appearance of the mucosa and vaginal wall was influenced by hormonal status. The presence of the vagina (45 patients), absence of the vagina (4), and the presence of duplication anomaly (3) were always accurately demonstrated on MR images. Carcinoma and metastases were depicted as tumor interrupting the low intensity signal of the muscular wall of the vagina. In two of three patients who underwent reconstructive surgery, postsurgical perivaginal abscesses developed that were correctly displayed on MR images. The normal and abnormal vaginas were exquisitely shown on MR images. For complicated congenital abnormalities, complications of postreconstructive surgery, and staging of neoplasms, MR imaging should be considered a primary imaging modality

  3. Vesicouterine fistula and blind vagina

    A case of vesicouterine fistula with blind vagina following cesarean section for obstructed labor is presented. It was surgically treated by fistulectomy, cervicoplasty and maintenance of bladder and cervical potency by catheterization. Intrauterine synechiae formation was prevented by copper T insertion and oral contraceptive pills. The patient is making uneventful a symptomatic progress planning to conceive. (author)

  4. Primary carcinoma of the vagina.

    Lilic, V; Lilic, G; Filipovic, S; Visnjic, M; Zivadinovic, R

    2010-01-01

    In this paper we reviewed the risk factors for primary carcinoma of the vagina (PCV), diagnostic and therapeutic modalities, and principles leading to rational decision-making in the individualized management of vaginal carcinoma patients. The review was based on the recent literature and our own years- long experience with the disease. PCV is a rare gynecologic malignancy accounting for about 2% of all neoplasms of the female genitals. Most of the affected women are over 60 years of age, peaking between 70 and 80 years. Only 10-15% of patients are below 50 years. Histopathologically, most common are squamous cell carcinoma (80-90%) and adenocarcinoma (4-10%). The leading risk factor for vaginal intraepithelial neoplasia (VAIN) and subsequent squamous cell vaginal carcinoma is long-lasting infection with human papillomavirus (HPV) type 16. Prognosis of the disease depends on several factors, the most important of which are age, histologic type, and tumor stage. Survival depends on the disease stage. Five -year survival rates are about 95% for stage 0, 75% for stage I, 60% for stage II, 35% for stage III, 20% for stage IVa, and 0% for IVb stage. Due to its being a rare entity, there are still controversies as to the most optimal treatment. Individualized treatment approaches have been increasingly used. In most centres, standard treatment for this cancer is radiotherapy. Some reports have shown that surgery might also be an option, while in some centres radiation is supplemented by cisplatin-based chemotherapy. The supposed advantage of radiotherapy is the preservation of the anatomy and function of the vagina. We believe that there are certain psychologic benefits with the preservation of the vagina, regardless of its function. However, preservation of the vaginal function after treatment of invasive vaginal cancer is a rare phenomenon, both in the literature and from our own experience. PMID:20658716

  5. Imaging of the vagina and vulva

    In gynecological daily practices, the vulva and vagina are examined during physical examination, however there are situations where this is not possible or it is needed to determine the extension of an injury through imaging methods. The magnetic resonance imaging is an excellent cross-sectional modality for evaluation the alterations of vulva and vagina due its multiplanar evaluation and high tecidual contrast. Other cross-sectional modalities are ultrasound and enhanced computed tomography. This paper intends to give an overview of vaginal and vulvar pathology that can be identified by the radiologist. (author)

  6. Endodermal sinus tumor of vagina in infants

    Brijesh Thakur

    2013-04-01

    Full Text Available Endodermal sinus tumor (or Yolk Sac tumor of the vagina is a rare malignant germ-cell tumor which is seen exclusively in children younger than 3 years of age. We report two cases of endodermal sinus tumor of the vagina. In both cases no radiological investigation was done and serum alpha-fetoprotein was elevated. The histopathological examination of both the tumor masses revealed vaginal endodermal sinus tumor. Periodic-acid-Schiff stain with diastase showed diastase resistant hyaline globules. These findings confirmed the diagnosis of endodermal sinus tumor in both cases. Vaginal endodermal sinus tumor is both locally aggressive and capable of metastasis. The serum alpha-fetoprotein level is a useful marker for diagnosis and monitoring the recurrence of vaginal endodermal sinus tumor in infants. Early detection and therapy is important because of its aggressive nature and good response to chemotherapy.

  7. The vagina : morphological, functional and ecological aspects

    Sjöberg, Inga

    1991-01-01

    The vagina is one organ of the body which has not been studied exhaustively. Moreover, most of the studies found in the contemporary literature have been performed on women affected by a variety of genital diseases. In the present study the vaginal epithelium was examined with a histological method, morphometry, whereby cyclical changes related to hormonal variation during the menstrual cycle were demonstrated. Determination of the quantity of estrogen receptors in the vaginal epithelium on t...

  8. Primary leiomyosarcoma of vagina: case report; Leiomiossarcoma primario de vagina: relato de caso

    Vieira, Leonardo Jose [Hospital ASCONCER Associacao Feminina de Prevencao e Combate ao Cancer, Juiz de Fora, MG (Brazil). Servico de Cirurgia; Freitas, Rosyane Rena de [Juiz de Fora Univ., MG (Brazil). Faculdade de Medicina; Oliveira, Alexandre Ferreira de [Juiz de Fora Univ., MG (Brazil). Faculdade de Medicina. Disciplina de Cirurgia Gastroenterologica; Assis, Raimunda Violante Campos de [Juiz de Fora Univ., MG (Brazil). Faculdade de Medicina. Dept. de Patologia; Cugola, Elaine Aline; Costa, Sandra Marcia Carvalho Ribeiro

    2004-07-01

    Primary malignant lesions of the vagina are uncommon and represent about 1% of all gynecological malignancies. Most of these neoplasms are carcinomas. Sarcomas comprise less than 2% of all malignant vaginal tumours. In this present article, we describe a primary vaginal leiomyosarcoma in a 40-years-old woman. (author)

  9. Rare case of primary mucinous adenocarcinoma of vagina

    Bharati Dhorepatil

    2013-01-01

    Full Text Available Here we present a rare case of primary mucinous adenocarcinoma of vagina treated successfully with wide local excision and post-operative radiotherapy. There was no recurrence even after four years.

  10. Vagina vasorum dissection during D2 lymphadenectomy for gastric carcinoma

    Jian-Jun Peng; Yu-Long He; Wen-Hua Zhan; Ping Xiao; Shi-Rong Cai; Chang-Hua Zhang; Hui Wu

    2007-01-01

    AIM:To explore the relationship between metastasis and vagina vasorum in the progress of gastric carcinoma and to find some facts and references for gastric surgeons.METHODS:One hundred and seven specimens of left or right gastric arteries (55 left and 52 right) were gathered from 59 patients undergoing radical gastrectomy for gastric carcinoma. All the frozen specimens were cut into 3 μm-thick sections and stained with hematoxylin-eosin (HE) and immunohistochemical method separately. Cytokeratin (CK) and mesothelial cells (MC) were stained with immunohistochemical method. Cancer cells inside vagina vasorum were detected and* the structure of artery wall was observed under microscope.RESULTS:Metastatic cancer cells or tubercles were found inside vagina vasorum in some stage Ⅲ or Ⅳ specimens,but not in stage Ⅰ or Ⅱ specimens. Tumor cells in vagina vasorum were CK positive in 26 specimens of 14 tumors. Among them,stage in was found in 4 specimens of 2 tumors,and stage Ⅳ in 22 specimens of 12 tumors. None of these specimens was positive for MC. The positive rate of CK increased with TNM staging. Compared with the lower part,tumors in the upper and middle parts of stomach were more,likely to metastasize into vagina vasorum.CONCLUSION:Vagina vasorum dissection should be performed during D2 lymphadenectomy for TNM stage Ⅲ or Ⅳ gastric carcinoma.

  11. Primary malignant melanoma of the vagina: a case report

    Jang, Ji Young; Kim, Do Kang; Lee, Eun Hee [College of Medicine, Catholic Univ., Seoul (Korea, Republic of); Kim, Jun Sang [College of Medicine, Chungnam National Univ., Daejeon (Korea, Republic of)

    2003-09-01

    A primary malignant melanoma of the vagina is a very rare gynecological malignant tumor. Its clinical behavior is more aggressive than that of cutaneous and vulvar melanomas. We present a case of a large sized primary melanoma of the lower third of the vagina, with a cervical lesion, in a 58-year-old postmenopausal woman. The patient was treated with conventional external radiation therapy and intracavitary radiotherapy (lCR), without surgical treatment. Although the primary lesion showed a partial response, the patient died of extensive metastases, which were found 4.5 months after the initial diagnosis. We suggest that shortening the treatment period, such as hypofractionated radiation therapy and surgical removal, and various systemic therapies for preventing early distant metastasis, are appropriate treatments for a primary malignant melanoma of the vagina, with a large tumor size.

  12. CONGENITAL ABSENCE OF THE VAGINA - RESULTS OF CONSERVATIVE TREATMENT

    LAPPOHN, RE

    1995-01-01

    Objective: To assess the efficacy of a combination of Frank's mold therapy with intercourse as a treatment for congenital vaginal aplasia. Study design: From 1973-1993, thirty-three patients with congenital aplasia of vagina and uterus were seen by one gynecologist. Patients with a partner were inst

  13. Over het ontstaan van het zure milieu in de vagina

    J.C. Hage

    1978-01-01

    textabstractDe bekleding van de vagina bestaat uit p!aveiselepitheel, dat opgebouwd is uit een basale, intermediaire en superficiële laag; de laatste bevat het meeste glycogeen (Rakoff e.a. 1944, Matter 1955, Gregoire e.a. 1971 ). De fluor vaginalis bevat glycogeen door exfoliatie van de oppervlakki

  14. SPINDLE CELL SARCOMA OF VAGINA- A CASE REPORT

    Sankareswari

    2013-04-01

    Full Text Available ABSTRACT : Malignant tumors of vagina are rare accounting for 1 to 4 % of all genital malignancies. Rarest of rare is spindle cell sarcoma of vagina having a very poor prognosis. 47yrs old, regularly menstruating woman, completed f amily, presented with hard painful ulcerated swelling near the vaginal introitus and l ower vaginal wall of 4 months duration. On examination, 2x4cms sized ulcerated growth with exc avated base, covered with necrotic material, present in the left antero-lateral lower e nd of vagina, inner to hymenal ring which was tender, hard, indurated, infiltrating, fixed to bas e and did not bleed to touch. Another nodule of size 1x1cm tender, hard, fixed and necrotic was pres ent below the external urethral meatus. HPE revealed Amelanotic malignant melanoma of vagin a. Immunohistochemistry revealed Spindle cell sarcoma of vagina. Tumor board recommen ded neo-adjuvant chemotherapy and radiotherapy (CT + EBRT. Of the recommended 50Gy, s he completed 46Gy in 23days and 1 course of chemotherapy (VAC. On review after 9 mont hs, the lesion disappeared clinically and she was advised to complete the treatment. Inspite o f radio and chemotherapy secondaries to lungs and brain could not be prevented and the patien t expired 20 months after the final diagnosis

  15. Management of radionecrosis of the vulva and distal vagina

    Twelve patients were seen between January 1983 and June 1989 with the clinical diagnosis of radionecrosis of the vulva or distal vagina. Seven patients received radiation for vulvar cancer, three for distal vaginal cancer, and two for recurrent endometrial cancer. No patient healed spontaneously and the mean delay in surgical therapy was 8.5 months. The radionecrotic site was treated with local therapy, radical local excision (with or without colostomy), or exenteration. The operative defect was closed primarily in three patients and covered with local flaps or myocutaneous flaps in seven patients. The two patients with local care still have radionecrotic ulcers. One of three patients who were closed primarily continues to have an ulcer. All other patients have healed satisfactorily except one who died after two attempts to correct the problem. Radionecrosis of the vulva and distal vagina should generally be treated surgically

  16. Management of radionecrosis of the vulva and distal vagina

    Roberts, W.S.; Hoffman, M.S.; LaPolla, J.P.; Ruas, E.; Fiorica, J.V.; Cavanagh, D. (Univ. of South Florida, Tampa (USA))

    1991-05-01

    Twelve patients were seen between January 1983 and June 1989 with the clinical diagnosis of radionecrosis of the vulva or distal vagina. Seven patients received radiation for vulvar cancer, three for distal vaginal cancer, and two for recurrent endometrial cancer. No patient healed spontaneously and the mean delay in surgical therapy was 8.5 months. The radionecrotic site was treated with local therapy, radical local excision (with or without colostomy), or exenteration. The operative defect was closed primarily in three patients and covered with local flaps or myocutaneous flaps in seven patients. The two patients with local care still have radionecrotic ulcers. One of three patients who were closed primarily continues to have an ulcer. All other patients have healed satisfactorily except one who died after two attempts to correct the problem. Radionecrosis of the vulva and distal vagina should generally be treated surgically.

  17. Nanoparticle transport from mouse vagina to adjacent lymph nodes.

    Byron Ballou

    Full Text Available To test the feasibility of localized intravaginal therapy directed to neighboring lymph nodes, the transport of quantum dots across the vaginal wall was investigated. Quantum dots instilled into the mouse vagina were transported across the vaginal mucosa into draining lymph nodes, but not into distant nodes. Most of the particles were transported to the lumbar nodes; far fewer were transported to the inguinal nodes. A low level of transport was evident at 4 hr after intravaginal instillation, and transport peaked at about 36 hr after instillation. Transport was greatly enhanced by prior vaginal instillation of Nonoxynol-9. Hundreds of micrograms of nanoparticles/kg tissue (ppb were found in the lumbar lymph nodes at 36 hr post-instillation. Our results imply that targeted transport of microbicides or immunogens from the vagina to local lymph organs is feasible. They also offer an in vivo model for assessing the toxicity of compounds intended for intravaginal use.

  18. Nanoparticle transport from mouse vagina to adjacent lymph nodes.

    Ballou, Byron; Andreko, Susan K; Osuna-Highley, Elvira; McRaven, Michael; Catalone, Tina; Bruchez, Marcel P; Hope, Thomas J; Labib, Mohamed E

    2012-01-01

    To test the feasibility of localized intravaginal therapy directed to neighboring lymph nodes, the transport of quantum dots across the vaginal wall was investigated. Quantum dots instilled into the mouse vagina were transported across the vaginal mucosa into draining lymph nodes, but not into distant nodes. Most of the particles were transported to the lumbar nodes; far fewer were transported to the inguinal nodes. A low level of transport was evident at 4 hr after intravaginal instillation, and transport peaked at about 36 hr after instillation. Transport was greatly enhanced by prior vaginal instillation of Nonoxynol-9. Hundreds of micrograms of nanoparticles/kg tissue (ppb) were found in the lumbar lymph nodes at 36 hr post-instillation. Our results imply that targeted transport of microbicides or immunogens from the vagina to local lymph organs is feasible. They also offer an in vivo model for assessing the toxicity of compounds intended for intravaginal use. PMID:23284844

  19. Radiosterilisation of the vagina in therapeutic doses - does it exist

    The endogenous genital flora is a major source of infections of the female genital tract, especially in patients with cervical or endometrial cancer. Until recently the 'radiosterilisation of the vagina', respectively a prophylactic and/or therapeutic effect of irradiation (external highvoltage as well as intracavitary-radium) concerning infections was postulated in the literature. This theory was disproved in a prospective clinical and bacteriological study covering 48 patients with advanced cervical cancer undergoing primary intracavitary radium-irradiation and 38 patients with inoperable endometrical cancer, undergoing primary iridium-192-afterloading. Following intracavitary radium for cervical cancer some typical nosocomial pathogens like Streptococcus faecalis, Enterobacter, Klebsiella, Proteus and Pseudomonas were isolated significantly more frequently than before treatment. Likewise, the mean number of aerobic bacterial species increased significantly after irradiation. Also primary Ir-192 (afterloading) irradiation did not alter the frequency of isolation of the resident flora in endometrial cancer patients. Therefore, 'radiosterilisation' of the vagina as result of radiotherapy does not exist. (orig.)

  20. Malignant peripheral nerve sheath tumor of the vagina

    Malignant peripheral nerve sheath tumors (MPNSTs) usually develop in major nerve trunks, giving rise to tumors in the proximal portions of the upper and lower extremities and trunk. The MPNSTs primarily occurring in the female genital tract are quite rare. We describe a case of MPNST of the vagina and discuss its diagnosis and treatment. This patient was treated definitively with radical local excision and is well with no signs of recurrence 2 years postoperatively. (author)

  1. Nanoparticle Transport from Mouse Vagina to Adjacent Lymph Nodes

    Byron Ballou; Andreko, Susan K.; Elvira Osuna-Highley; Michael McRaven; Tina Catalone; Bruchez, Marcel P.; Hope, Thomas J.; Labib, Mohamed E.

    2012-01-01

    To test the feasibility of localized intravaginal therapy directed to neighboring lymph nodes, the transport of quantum dots across the vaginal wall was investigated. Quantum dots instilled into the mouse vagina were transported across the vaginal mucosa into draining lymph nodes, but not into distant nodes. Most of the particles were transported to the lumbar nodes; far fewer were transported to the inguinal nodes. A low level of transport was evident at 4 hr after intravaginal instillation,...

  2. KANDIDIASIS VAGINA YANG MENDAPAT TERAPI SISTEMIK DAN TOPIKAL: SEBUAH LAPORAN KASUS

    Dewa Made Rendy Sanjaya

    2014-08-01

    Full Text Available Kandidiasis vulvovaginitis ialah penyakit jamur candida yang mengenai mukosa vagina danvulva.Penyebabnya yang tersering biasanya adalah candida albicans.Gejala klinis KandidiasisVulvovaginitis ialah gatal didaerah vulva, dan pada yang berat terdapat rasa panas,dispaneuria.lesi eritema, hiperemis dilabia mayora, dan vagina 1/3 bawah. Dilaporkan satu  kasusseorang wanita. berumur 26 tahun dengan keluhan keputihan pada daerah vagina sertamengalami kegatalan dan rasa nyeri terjadi sejak 2 minggu yang lalu. Pada gambaran klinis tampak dinding vagina eritema, erosi dengan secret putih kental. Pada pengecatan gram darisecret mukosa vagina didapatkan leukosit blastopsora dan pseudohifa. Pemerikaan KOH 10%dari sekret vagina didapatkan blastopore dan pesudohifa.Penanganan yang diberikan adalah obatsistemik dengan flukonazol 1x150 mg dosis tunggal dan topical diberikan ketokenazol cream.Prognosis kasus tersebut adalah baik..

  3. Management of radiation injuries of vulva and vagina

    Fraunholz, I.B.; Schopohl, B.; Boettcher, H.D. [Klinik fuer Strahlentherapie und Onkologie, Johann-Wolfgang-Goethe-Universitaet Frankfurt am Main (Germany)

    1998-11-01

    Background: Acute and late injuries of vulva and vagina are frequent and potentially serious complications in radiotherapy of gynecologic tumors. They still are reported poorly in literature. Methods: Based on a literature search a survey will be given of the modalities, which are used or recommended for prophylaxis or treatment of these radiation injuries. The principles of the different measures will be discussed with available study results. Results: Hygiene measures and the topical application of antimicrobial or granulation stimulating substances, which is mostly based on long standing clinical experience, are the principles of the treatment of acute reactions of vulva and vagina. The topical use of estrogen, which promotes proliferation of epithelium, is generally described in connection with treatment and prophylaxis of late radiation injuries. As a prophylaxis for the late reaction of vaginal stenosis, vaginal dilatation is recommended in literature. Conclusion: With the exception of a few reports on estrogen, there are no data about the effectiveness of the currently used medical substances. The local application of estrogen as prophylaxis of the acute reactions will therefore be examined in a prospective study. (orig.) [Deutsch] Hintergrund: Akute und spaete Reaktionen an Vulva und Vagina sind haeufige und zum Teil schwerwiegende Nebenwirkungen der Strahlentherapie von gynaekologischen Tumoren, auf die in der Literatur kaum eingegangen wird. Methoden: Basierend auf einer umfangreichen Literaturrecherche, werden die Massnahmen, die zur Prophylaxe oder Therapie dieser Strahlenreaktionen zur Verfuegung stehen, systematisch zusammengestellt und, soweit verfuegbar, mit Ergebnissen aus Studien diskutiert. Ergebnisse: Hygienemassnahmen und die auf klinischen Erfahrungswerten basierende lokale Anwendung einer Vielzahl von mehr oder weniger antimikrobiell wirkenden oder granulationsfoerdernden Substanzen lassen sich als Grundprinzipien der Behandlung von akuten

  4. Pelvic Myxoid Leiomyoma Mass between Vagina and Rectum.

    AlShalabi, Omar; Alahmar, Fadi Obaied; Aljasem, Hazem; Alsaid, Bayan; AlShalabi, Abdulghani

    2016-01-01

    Leiomyomas are the most common pelvic tumors in women. About 20-30% of women older than 35 are affected. Rare conditions of leiomyomas have extrauterine locations. Myxoid degeneration is a rare type of leiomyoma degeneration. We report a case of solid-cystic myxoid leiomyoma in a 53-year-old woman complained of constipation, urinary hesitation, and malodorous vaginal discharge with palpable 17 × 12 cm mass between vagina and rectum. Regarding the inferior location of the mass, a perineal approach was used to enucleate it. This rare location has not been mentioned before. The woman was finally diagnosed by pathologists which was myxoid leiomyoma. PMID:27429825

  5. Management of radiation injuries of vulva and vagina

    Background: Acute and late injuries of vulva and vagina are frequent and potentially serious complications in radiotherapy of gynecologic tumors. They still are reported poorly in literature. Methods: Based on a literature search a survey will be given of the modalities, which are used or recommended for prophylaxis or treatment of these radiation injuries. The principles of the different measures will be discussed with available study results. Results: Hygiene measures and the topical application of antimicrobial or granulation stimulating substances, which is mostly based on long standing clinical experience, are the principles of the treatment of acute reactions of vulva and vagina. The topical use of estrogen, which promotes proliferation of epithelium, is generally described in connection with treatment and prophylaxis of late radiation injuries. As a prophylaxis for the late reaction of vaginal stenosis, vaginal dilatation is recommended in literature. Conclusion: With the exception of a few reports on estrogen, there are no data about the effectiveness of the currently used medical substances. The local application of estrogen as prophylaxis of the acute reactions will therefore be examined in a prospective study. (orig.)

  6. Normal tissue tolerance to external beam radiation therapy: The vagina

    The vagina is a virtual cavity involved in sexual reproduction field. Due to its anatomical location, it may be exposed in whole or in part to ionizing radiation in external radiotherapy and/or brachytherapy of the pelvic region. This review aims to describe the vaginal acute and late side effects due to radiation, probably inadequately reported in the literature. Medline and PubMed literature searches were performed using the keywords -vaginal - radiotherapy - toxicity. The acute and late functional changes after external beam radiation consist mainly of drought. Their incidences are poorly described in the literature and the delivered doses even less. Recommendations are non-existent as the normal tissue complication probability (NTCP). Brachytherapy delivers high and heterogeneous doses, making it difficult to estimate the dose. The concomitant administration of chemotherapy appears to be a factor increasing the risk of toxicity. Modern techniques of conformal radiotherapy with modulated intensity appear to have little impact on this body. Only a maximum dose on each third of the vagina appears to be currently proposed to avoid the risk of side effects. (authors)

  7. A longitudinal study of Staphylococcus hyicus colonization of vagina of gilts and transmission to piglets

    Wegener, Henrik Caspar; Skov Jensen, E.W.

    1992-01-01

    typing, as well as characterization of about 10 % of the isolates by plasmid profiles and antibiogram patterns, showed that, several different clones of S. hyicus could be present simultaneously in vagina of gilts and also on skin of piglets. Generally isolates from the vagina of one animal were...

  8. Malignant melanoma of the vagina: a report of 2 cases

    Kim, Ok Bae; Kim, Jin Hee; Jung, Young Yeon; Cho, Chi Heum; Choi, Tae Jin [Dongsan Medical Center, School of Medicine, Keimyung University, Daegu (Korea, Republic of)

    2005-06-15

    Primary malignant melanoma of the vagina is an extremely rare genital neoplasm occurring mainly in postmenopausal women. It has a worse prognosis than cutaneous melanomas, because of the high rate of locoregional recurrences and rapid systemic dissemination. In the past, radical surgical extirpation as the primary management had been recommended to improve loco-regional control, and possibly overall survival. However, the prognosis was poor in spite of such a radical approach. Recently, more conservative treatment such as wide local excision combined with adjuvant high-dose fraction radiotherapy seems to have promising results. Primary radiation therapy could be served as an alternative to surgery for patients with lesion less than 3 cm in diameter. We report 2 cases of primary vaginal malignant melanoma treated with radiotherapy.

  9. Surgical Management of the Constricted or Obliterated Vagina.

    Gebhart, John B; Schmitt, Jennifer J

    2016-08-01

    Management of the constricted or obliterated vagina demands an understanding and recognition of the potential etiologies leading to this presentation. A thorough and comprehensive medical and surgical review is required to arrive at an accurate diagnosis, which then will guide medical or surgical intervention. It is paramount to recognize when underlying medical conditions are contributing to these conditions and to begin medical therapy; failure to do so will often yield suboptimal results. When these conditions arise after surgical interventions, compensatory surgical techniques that correct upper and lower vaginal strictures or obliteration include incision through the stricture, vaginal advancement, Z-plasty, skin grafts, perineal flaps, and abdominal flaps and grafts. Postoperative surveillance and dilation are critical to optimize long-term success. PMID:27399991

  10. Particles translocate from the vagina to the oviducts and beyond

    Wehner, A.P.; Hall, A.S.; Weller, R.E.; Lepel, E.A.; Schirmer, R.E.

    1985-03-01

    To investigate whether particles deposited in the vagina translocate to the oviducts, 0.3 ml of a 4% bone black suspension was deposited in the posterior vaginal fornix of each of five cynomolgus monkeys (Macaca fascicularis) during their mid-menstrual cycle. Simultaneously, each animal received 10 units of oxytocin by intramuscular injection. The oviducts of three animals were removed 1 hr after administration of the bone black, while those of the remaining two animals were removed 72 hr after dosing. The removed oviducts were flushed with Hank's solution and then with collagenase solution. The solutions were collected in clean vials and filtered. The filters were examined for bone black particles by light microscopy, as were filters through which solution blanks (negative controls) had been passed. Particles resembling bone black were found on all filters. There were no appreciable differences in the number or shape of these particles between the solution-blank filters and the oviduct-flush filters. The particles on both the solution-blank filters and on the oviduct-flush filters probably originated from environmental contamination by ubiquitous carbon particles. While these results suggested that no translocation took place, translocation could not be ruled out with certainty in the absence of quantitative analyses. A more definitive pilot study was then conducted with two dosed monkeys and one control, using talc labelled by neutron activation to circumvent the problem of environmental contamination. Gamma-Ray analysis of tissue and peritoneal lavage samples for the radionuclides /sup 46/Sc, /sup 59/Fe and /sup 60/Co indicated that no measurable quantities (i.e. greater than 0.5 micrograms) of talc translocated from the deposition site in the vagina to the uterine cavity and beyond.

  11. Radiation-induced morphological changes in the vagina

    Kirchheiner, K.; Fidarova, E.; Schmid, M.P.; Sturdza, A.; Kranz, A.; Poetter, R. [Medical Univ. of Vienna (Austria). Dept. of Radiation Oncology; Nout, R.A. [University Medical Center Leiden (Netherlands). Dept. of Clinical Oncology; Wiebe, E. [Alberta Univ., Cross Cancer Institute, Edmonton, AB (Canada). Dept. of Radiation Oncology; Polterauer, S. [Medical Univ. of Vienna (Austria). Dept. of General Gynecology and Gynecologic Oncology; Doerr, W. [Medical Univ. of Vienna (Austria). Dept. of Radiation Oncology; Medical Univ. of Vienna (Austria). Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology

    2012-11-15

    Background and purpose: Treatment-induced chronic vaginal changes after definitive radio(chemo)therapy for locally advanced cervical cancer patients are reported as one of the most distressing consequences of treatment, with major impact on quality of life. Although these vaginal changes are regularly documented during gynecological follow-up examinations, the classic radiation morbidity grading scales are not concise in their reporting. The aim of the study was therefore to identify and qualitatively describe, on the basis of vaginoscopies, morphological changes in the vagina after definitive radio(chemo)therapy and to establish a classification system for their detailed and reproducible documentation. Patients and methods: Vaginoscopy with photodocumentation was performed prospectively in 22 patients with locally advanced cervical cancer after definitive radio(chemo)therapy at 3-24 months after end of treatment. All patients were in complete remission and without severe grade 3/4 morbidity outside the vagina. Results: Five morphological parameters, which occurred consistently after treatment, were identified: mucosal pallor, telangiectasia, fragility of the vaginal wall, ulceration, and adhesions/occlusion. The symptoms in general were observed at different time points in individual patients; their quality was independent of the time of assessment. Based on the morphological findings, a comprehensive descriptive and semiquantitative scoring system was developed, which allows for classification of vaginal changes. A photographic atlas to illustrate the morphology of the alterations is presented. Conclusion: Vaginoscopy is an easily applicable, informative, and well-tolerated procedure for the objective assessment of morphological vaginal changes after radio(chemo)therapy and provides comprehensive and detailed information. This allows for precise classification of the severity of individual changes. (orig.)

  12. Colocolpopoiesis : the use of sigmoid colon in the treatment of conditions associated with absence of the vagina

    I. Freundt (Ingrid)

    1994-01-01

    textabstractThe creation of a coitally functional vagina is an important part of sexual rehabilitation in patients with congenital or acqnired absence of the vagina, and in male-to-female transsexuals. Various conservative and surgical techniques have been developed to construct an artificial vagina

  13. High-dose-rate brachytherapy for cervical carcinoma patients with narrow vagina

    Yorozu, Atsunori; Toya, Kazuhito; Kawase, Takatugu [National Tokyo Medical Center, Tokyo (Japan); Dokiya, Takushi [Saitama Medical Coll., Moroyama (Japan)

    2002-06-01

    We retrospectively analyzed cervical cancer patients with narrow vagina treated by high-dose-rate (HDR) brachytherapy followed by external beam irradiation. Fifty patients were treated with radical radiotherapy between 1992 and 1999 at the National Tokyo Medical Center. All patients received 30 Gy of external whole pelvic irradiation and 20 Gy of pelvic irradiation with a central shield. After 30 Gy of whole pelvic irradiation, 24 Gy of fractionated brachytherapy was applied with a tandem and ovoids, non-rigid type developed in the Cancer Institute, according to the Manchester method. Nineteen patients with a narrow vagina of less than 40 mm in width were compared with 31 other patients (control group). The 5-year cumulative survival rates were 56% in the patients with a narrow vagina and 53% in the control group (P=0.6008). The control rate in the pelvis was not significantly different between the two groups. The cumulative rate of rectal complications of the patients with a narrow vagina was more frequent than the control group (58% vs 29%) (P=0.0924). Severe rectal bleeding was also more frequent in the patients with a narrow vagina. The estimated maximal dose of the rectal wall was significantly higher in patients with a narrow vagina. This result suggests that a lower brachytherapy dose is necessary for patients with narrow vagina considering the rectal sequelae in the case of using our methods. (author)

  14. Carcinoma of vagina 10 or more years following pelvic irradiation therapy

    Gynecologic cancer records of 4,238 patients treated between 1956 and 1974 were reviewed. Sixteen patients developed neoplasia in the cervix or vagina 10 or more years following pelvic irradiation. Three patients had squamous carcinoma in situ; the other 13 patients had invasive squamous cancer involving the upper vagina. Only 1.26 percent of invasive carcinoma of the cervix treated by radiation therapy from 1956 to 1966 presented with a late or recurrent or new primary tumor involving the vagina or cervix 10 or more years after primary treatment. The authors conclude that the risk of developing radiation-induced carcinoma in the upper vagina or cervix following pelvic irradiation is low. Follow-up Pap smears are indicated for all patients treated for cervical or vaginal malignancies by radiation therapy in order to detect vaginal neoplasia as well as recurrent carcinoma of the cervix

  15. Exclusive radiotherapy for primary squamous cell carcinoma of the vagina

    Purpose: To retrospectively analyze results of external beam therapy (EBT) with brachytherapy (BT) for primary vaginal squamous cell carcinoma (PVSCC). Materials and methods: From 1970 to 2001, 91 patients were included. FIGO stages were: I (29%), II (38%), III (29%) and IVa (4%). EBT delivered a median total dose of 50 Gy to the pelvis. BT was performed with a customized intra-vaginal applicator and in 36% of applications combined endocavitary and interstitial BT. ICRU Report 38 parameters were reported. Results: The 5-year cause specific survival (CSS) rates were: 83% for stage I, 76% for stage II, 52% for stage III, and 2 of the 4 stage IVa patients died 9 and 36 months after treatment. The 5-year pelvis control rates were: 79% for stage I and II and 62% for stage III. Recurrences as a first event were local only in 68% of cases, nodal only in 10%, metastatic only in 13% and combined in 9%. In multivariate analysis: stage (I and II versus II and IV), response to EBT (evaluated at BT), and the number of BT applications were statistically significant for CSS. Grade 2-3 toxicities were as follows (Franco-Italian Glossary): rectum (n = 3), sigmoid colon and small bowel (n = 8), bladder (n = 5), ureter (n = 4) and vagina (n = 13). Anterior location of the tumor increased bladder toxicity (p = 0.01) and total reference air kerma was higher in patients who experienced grade 2-3 urinary or digestive toxicity (p = 0.03). Conclusion: EBT with BT is an effective treatment for patients with stage I-II PVSCC. The incidence and severity of late toxicity were relatively low. Recent advances in the treatment of cervix carcinoma emphasize the need for concomitant radio-chemotherapy in stages III-IV and the use of MRI for treatment planning

  16. Non-Diethylstilbestrol-Associated Primary Clear Cell Carcinoma of the Vagina: Two Case Reports with Immunohistochemical Studies and Literature Review

    Shagufta T. Mufti; Hiba Hassan Ali

    2015-01-01

    Primary clear cell adenocarcinomas most commonly involve the genitourinary system, including the vagina. Previously, primary clear cell adenocarcinomas of the vagina have been discussed within the context of prenatal exposure to diethylstilbestrol. Due to its widely proven role in the development of this carcinoma, administration of diethylstilbestrol is prohibited. We present two cases of non-diethylstilbestrol-associated primary clear cell adenocarcinoma of the vagina from the archives of t...

  17. Sensibility of vagina reconstructed by McIndoe method in Mayer-Küster-Rokitansky-Hauser syndrome

    Vesanović Svetlana; Panajotović Ljubomir; Garalejić Elijana

    2008-01-01

    Background/Aim. Congenital absence of vagina is a failure present in Mayer-Küster-Rokitansky-Hauser syndrome. Treatment of this anomaly includes nonoperative and operative procedures. McIndoe procedure uses split skin graft by Thiersch. The aim of this study was to determine sensitivity (touch, warmness, coldness) of a vagina reconstructed by McIndoe method in Mayer-Küster-Rokitansky-Hauser syndrome and compare it with the normal vagina. Methods. A total of 21 female persons with reconstructe...

  18. Endodermal sinus tumor of the vagina in children: a report of two cases.

    Gangopadhyay, Mimi; Raha, Kalpana; Sinha, Swapan K; De, Anuradha; Bera, Pranati; Pati, Shyamapada

    2009-01-01

    Malignant tumors of the vagina in infants and children are rare, with primary germ cell tumor (endodermal sinus tumor [EST]) being rarer, which carries a dismal prognosis. This tumor is often clinically mistaken as botryoid rhabdomyosarcoma and, on histopathological examination, is often misdiagnosed as clear cell adenocarcinoma. Two cases of EST of the vagina in infants aged 9 and 17 months are reported. Both the patients presented with bleeding per vagina and clinically and by ultrasonography were diagnosed as sarcoma botryoides. Both were diagnosed as primary yolk sac tumors. The serum alfa fetoprotein (AFP) level was 4325 and 9328 ng/ml, respectively. One patient aged 9 months expired 2 months after receiving chemotherapy. The other, aged 17 months, was given chemotherapy followed by surgery with reduction of the AFP levels. PMID:19679975

  19. Ultrastructural characteristics of the vaginae of the basal monogenean Chimaericola leptogaster (Leuckart, 1830).

    Poddubnaya, Larisa G; Hemmingsen, Willy; Gibson, David I

    2013-12-01

    In the first study of the vaginal ultrastructure of any monogenean, the paired vaginae of Chimaericola leptogaster, a basal polyopisthocotylean from the gills of a holocephalan, are described. Each vagina opens laterally. A unique feature of this relict parasite is a short vagino-intestinal connecting duct, the lining of which is separated by septate junctions from the linings of the vagina and the intestine. After giving rise to this vagino-intestinal duct, each vagina travels in a posterior direction and opens into the vitelline collecting duct. The lining of each vagina close to the vaginal pore resembles the body tegument, the syncytial lining of which measures about 2.5 μm in thickness and has a dense surface layer 0.2 μm in thickness and different apical projections. Proximal to this and before the entrance to the vaginal-intestinal duct, the vaginal lining is characterised by: uniformly distributed electron-dense, lanceolate, spine-like surface structures of about 1.7 μm in length; three kinds of surrounding glands with three kinds of secretory granules (abundant oval or rounded electron-dense granules 0.7-2.5 μm in length, much less numerous spheroidal, vesicular granules 0.3-0.4 μm in diameter, and tightly packed, spheroidal granules 0.8 μm in diameter and containing fine particulate material of low density); and four kinds of sensory receptors (three uniciliate and one aciliate). These features are absent from the rest of the vagina. The likely roles of the vagino-intestinal connection, the different gland cells, sensory structures, and the armament of the distal vaginal regions are discussed. Considering the suggested polyopisthocotylean ancestor for the Neodermata, the relict parasite fauna of holocephalans and the unique vagino-intestinal connection in C. leptogaster, which is also known in turbellarians, an ancient origin for chimaericolids is supported. PMID:24043615

  20. Carcinoma of the vulva and vagina in patients irradiated for carcinoma of the cervix

    Six patients with carcinoma of the vulva and 3 with carcinoma of the vagina following radiation therapy for cancer of the cervix were analyzed. The interval between irradiation and diagnosis of the second tumor varied from 5 to 23 years. Despite the lack of having detailed information on irradiation factors in all patients, circumstantial evidence from this study suggests that radiation therapy may have contributed to the development of carcinoma of the vulva and vagina in some of the patients. Close follow-up patients treated for squamous carcinoma of the genital tract must emphasize inspection for new lesions. The incidences previously reported in the literature are also reviewed for comparison. (author)

  1. Carcinoma of the vulva and vagina in patients irradiated for carcinoma of the cervix

    Tsukiyama, Iwao; Kakehi, Masae; Ono, Ryosuke; Watai, Kiichi; Yanagawa, Shigeo; Kasamatsu, Tatsuhiro

    1984-08-01

    Six patients with carcinoma of the vulva and 3 with carcinoma of the vagina following radiation therapy for cancer of the cervix were analyzed. The interval between irradiation and diagnosis of the second tumor varied from 5 to 23 years. Despite the lack of having detailed information on irradiation factors in all patients, circumstantial evidence from this study suggests that radiation therapy may have contributed to the development of carcinoma of the vulva and vagina in some of the patients. Close follow-up patients treated for squamous carcinoma of the genital tract must emphasize inspection for new lesions. The incidences previously reported in the literature are also reviewed for comparison. (author).

  2. Committee Opinion No. 571: Solutions for surgical preparation of the vagina.

    2013-09-01

    Currently, only povidone-iodine preparations are approved for vaginal surgical-site antisepsis. However, there are compelling reasons to consider chlorhexidine gluconate solutions for off-label use in surgical preparation of the vagina, especially in women with allergies to iodine. Although chlorhexidine gluconate solutions with high concentrations of alcohol are contraindicated for surgical preparation of the vagina, solutions with low concentrations of alcohol (eg, 4%) are both safe and effective for off-label use as vaginal surgical preparations and may be used as an alternative to iodine-based preparations in cases of allergy or when preferred by the surgeon. PMID:23963423

  3. Imaging of the vagina and vulva; Aspectos de imagem das lesoes vulvo-vaginais

    Souza, Luis Ronan Marquez Ferreira de; Szejnfeld, Jacob [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. de Diagnostico por Imagem]. E-mail: luisronan@gmail.com; Borges, Leonardo Romualdo; Rosalen Junior, Roberto Antonio [Universidade Federal do Triangulo Mineiro (UFTM), Uberaba, MG (Brazil); Signorini Filho, Roney Cesar; Marques, Renato Moretti; Nicolau, Sergio Mancini [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Disciplina de Oncoginecologia; Goldman, Suzan Menasce [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. de Diagnostico por Imagem

    2006-10-15

    In gynecological daily practices, the vulva and vagina are examined during physical examination, however there are situations where this is not possible or it is needed to determine the extension of an injury through imaging methods. The magnetic resonance imaging is an excellent cross-sectional modality for evaluation the alterations of vulva and vagina due its multiplanar evaluation and high tecidual contrast. Other cross-sectional modalities are ultrasound and enhanced computed tomography. This paper intends to give an overview of vaginal and vulvar pathology that can be identified by the radiologist. (author)

  4. Safety, Efficiency, and Outcomes of Perineoplasty: Treatment of the Sensation of a Wide Vagina.

    Ulubay, Mustafa; Keskin, Ugur; Fidan, Ulas; Ozturk, Mustafa; Bodur, Serkan; Yılmaz, Ali; Kinci, Mehmet Ferdi; Yenen, Mufit Cemal

    2016-01-01

    Background. The sensation of a wide vagina is a common problem for women after childbirth. As its etiology is unknown, there is no uniform management strategy. We hypothesized that, rather than vaginal laxity, the cause was level 3 pelvic support deficiency. Methods. This retrospective study compared preoperative and postoperative genital hiatus length, perineal length, and total vaginal length in patients treated with perineoplasty for the sensation of a wide vagina. A telephone survey was used to determine postoperative patient and male partner satisfaction rates. Results. Mean age of patients was 48 (26-68) years; mean body mass index (BMI) was 25.3 (17.6-33.2); and mean parity was 2.5 (2-5). Preoperative and postoperative genital hiatus, perineal length, and total vaginal length were 4.62 and 3.18 (p vagina. Conclusion. With low dyspareunia rates, low complication rates, high patient satisfaction, and satisfactory anatomical success, perineoplasty can be considered successful for treatment of the sensation of a wide vagina. PMID:27610368

  5. A RARE CASE OF PRIMARY MALIGNANT MELANOMA OF THE VAGINA IN A YOUNG LADY: A REPOR

    Sangeeta

    2013-10-01

    Full Text Available ABSTRACT : Malignant melanoma of vagina is a rare tumor with incidence rate of only 0.46 c ases per one million women per year and less than 250 cases have been reported in medical literature till date. It has a notoriously aggressive behavior and is associated with a high risk of local recurrence and distant metastasis. At present, there are va rious treatment options for this disease but no standard guideline. It accounts for less than 1% of all malignant melanoma and less than 3% of all primary malignant tumors of the vagina. Conventional imaging techniques i.e. computed tomography, may be sub - optimal in evaluating a small volume of tumor, which may lead to inaccurate staging of a loco - regional tumor . The optimal treatment for vaginal melanoma is a subject of debate. Malignant melanoma of the vagina is a disease of postmenopausal women, with 75 % of women being more than 50 years of age . Here, we present a case of primary vaginal malignant melanoma in a 35 year woman located in lower 1/3 rd of the vagina

  6. Hematocolpos in double vagina associated with uterus didelphus: US and MR findings

    Ballesio, L.; Andreoli, C.; De Cicco, M.L.; Angeli, M.L.; Manganaro, L

    2003-02-01

    The malformative syndrome of double vagina in association with uterus didelphus and kidney agenesis is a rare condition, often asymptomatic: if this condition is accompanied by imperforated obstructed hemivagina, the clinical manifestations depend on the presence of hematocolpos. MRI plays an important role for diagnosis because it allows to characterize the nature of the lesion and to evaluate the anatomical details of the uterine malformation. The authors describe this complex genital malformation and discuss the main US and MRI features.

  7. Measuring the space between vagina and rectum as it relates to rectocele

    Jin Liu; Li-Dong Zhai; Yun-Sheng Li; Wan-Xiang Liu; Rui-Hua Wang

    2009-01-01

    AIM: To measure the normal space between the posterior wall of the vagina and the anterior wall of the respectively rectum using computed tomography (CT) and reveal its were relationship to rectocele. METHODS: A total of twenty female volunteers without rectocele were examined by CT scan. We performed a middle level continuous horizontal pelvic scan from the upper part to the lower part and collected the measurement data to analyze the results using t -test. RESULTS: Twenty volunteers were enrolled in the study. The space between the posterior wall of the vagina and the anterior wall of the rectum was measured at three levels (upper 1/3, middle, lower 1/3 level of vagina).The results showed that the space from the posterior wall of the vagina to the anterior wall of the rectum at the upper 1/3 level and the middle level was 3.896 ± 0.3617 mm and 4.6575 ± 0.3052 mm, respectively. When the two groups of data were compared, we found the space at the upper 1/3 level was shorter than at the middle level (P < 0.01). Moreover, at the lower 1/3 level the space measured was 10.058 ± 0.4534 mm. The results revealed that the space at the lower 1/3 level was longer than that at the middle level (P < 0.01). CONCLUSION: These measurement data may be helpful in assessing rectocele clinical diagnosis and functional outcomes of rectocele repair.

  8. Long-term results of radiotherapy in primary carcinoma of the vagina

    Hegemann, Stefan; Willich, Normann [University Hospital, Muenster (Germany). Dept. of Radiotherapy and Radiation Oncology; Schaefer, Ulrich [University Hospital, Muenster (Germany). Dept. of Radiotherapy and Radiation Oncology; Lippe Hospital, Lemgo (Germany). Dept. of Radiotherapy; Lelle, Ralph [University Hospital, Muenster (Germany). Dept. of Gynecology and Gynecologic Oncology; Micke, Oliver [University Hospital, Muenster (Germany). Dept. of Radiotherapy and Radiation Oncology; Franziskus Hospital, Bielefeld (Germany). Dept. of Radiotherapy and Radiation Oncology

    2009-03-15

    Background: The long-term results of radiotherapy in primary carcinoma of the vagina are not well defined. Patients and Methods: The treatment results of 41 patients with primary malignancies of the vagina were analyzed. The mean follow-up period was 77.3 months (2.3-404 months). The predominant histology was squamous cell carcinoma, FIGO stages I: n = 7 (17.1%), II: n = 13 (31.7%), III: n = 13 (31.7%), and IVa: n = 8 (19.5%). Radiotherapy was the primary treatment for all patients. None of the patients had undergone prior surgery for vaginal carcinoma. The majority of patients received pelvic irradiation, including treatment of the inguinal lymphatics (median dose: 50 Gy). 26 patients received additional intravaginal brachytherapy. Results: Overall, 21 patients (51.2%) achieved complete remission, 17 patients (41.5%) had partial responses, and three patients (7.3%) had no change or progressive disease. The total median survival of the analyzed patients was 41.3 months. The 1-year survival probability was 85.4%, the 5-year survival probability 40.6%, and the 10-year survival probability 27.2%. Univariate analysis revealed a survival advantage for earlier tumor stages (FIGO I and II) compared to advanced stages (FIGO III and IV), with a median survival of 58.1 months compared to 26.8 months. Treatment side effects were tolerable and easily managed. Conclusion: Definite radiotherapy is the treatment of choice for primary carcinomas of the vagina. Considering that primary malignancies of the vagina are typically diseases of the elderly, it should be noted that radiotherapy is especially well tolerated in this population. (orig.)

  9. CT and MR imaging findings of primary leiomyosarcoma of the vagina : a case report

    Cho, So Hee; Rha, Sung Eun; Cho, Song Mee; Byun, Jae Young [College of Medicine, The Catholic Univ. of Korea, Seoul (Korea, Republic of)

    2001-09-01

    Primary malignant lesions of the vagina are uncommon and represent approximately 1-2% of all gynecologic malignancies. About 2% of all malignant vaginal lesions are primary sarcomas, the most common of these being leiomyosarcoma. We report the CT and MR imaging findings in a 41-year-old woman with vaginal leiomyosarcoma presenting as a bulky solid mass which caused expansion of the vaginal canal.

  10. Regional variation in tissue composition and biomechanical properties of postmenopausal ovine and human vagina.

    Daniela Ulrich

    Full Text Available OBJECTIVE: There are increasing numbers of reports describing human vaginal tissue composition in women with and without pelvic organ prolapse with conflicting results. The aim of this study was to compare ovine and human posterior vaginal tissue in terms of histological and biochemical tissue composition and to assess passive biomechanical properties of ovine vagina to further characterise this animal model for pelvic organ prolapse research. STUDY DESIGN: Vaginal tissue was collected from ovariectomised sheep (n = 6 and from postmenopausal women (n = 7 from the proximal, middle and distal thirds. Tissue histology was analyzed using Masson's Trichrome staining; total collagen was quantified by hydroxyproline assays, collagen III/I+III ratios by delayed reduction SDS PAGE, glycosaminoglycans by dimethylmethylene blue assay, and elastic tissue associated proteins (ETAP by amino acid analysis. Young's modulus, maximum stress/strain, and permanent strain following cyclic loading were determined in ovine vagina. RESULTS: Both sheep and human vaginal tissue showed comparable tissue composition. Ovine vaginal tissue showed significantly higher total collagen and glycosaminoglycan values (p<0.05 nearest the cervix. No significant differences were found along the length of the human vagina for collagen, GAG or ETAP content. The proximal region was the stiffest (Young's modulus, p<0.05, strongest (maximum stress, p<0.05 compared to distal region, and most elastic (permanent strain. CONCLUSION: Sheep tissue composition and mechanical properties showed regional differences along the postmenopausal vaginal wall not apparent in human vagina, although the absolute content of proteins were similar. Knowledge of this baseline variation in the composition and mechanical properties of the vaginal wall will assist future studies using sheep as a model for vaginal surgery.

  11. Placement of temperature probe in bovine vagina for continuous measurement of core-body temperature

    Lee, C. N.; Gebremedhin, K. G.; Parkhurst, A.; Hillman, P. E.

    2015-09-01

    There has been increasing interest to measure core-body temperature in cattle using internal probes. This study examined the placement of HOBO water temperature probe with an anchor, referred to as the "sensor pack" (Hillman et al. Appl Eng Agric ASAE 25(2):291-296, 2009) in the vagina of multiparous Holstein cows under grazing conditions. Two types of anchors were used: (a) long "fingers" (4.5-6 cm), and (b) short "fingers" (3.5 cm). The long-finger anchors stayed in one position while the short-finger anchors were not stable in one position (rotate) within the vagina canal and in some cases came out. Vaginal temperatures were recorded every minute and the data collected were then analyzed using exponential mixed model regression for non-linear data. The results showed that the core-body temperatures for the short-finger anchors were lower than the long-finger anchors. This implied that the placement of the temperature sensor within the vagina cavity may affect the data collected.

  12. Borderline malignant change in recurrent müllerian papilloma of the vagina.

    Dobbs, S P; Shaw, P A; Brown, L J; Ireland, D.

    1998-01-01

    Malignant change occurred in a benign, recurrent vaginal müllerian polyp. The patient, a 49 year old woman with cerebral palsy, presented with a polypoid mass in the vagina. At four years of age she had presented with a haemorrhagic polyp, and over the following years she had recurrent irregular bleeding and regrowth of the polypoidal mass, requiring a total of 10 operations to excise the polyp. Histological examination of the specimen showed typical müllerian features with tubal, endometrioi...

  13. Fractionated stereotactic radiotherapy with vagina carotica protection technique for local residual nasopharyngeal carcinoma after primary radiotherapy

    LIU Feng; HUAN Fu-kui; FANG Hao; WAN Bao; LI Ye-xiong; XIAO Jian-ping; XU Ying-jie; ZHANG Ye; XU Guo-zhen; GAO Li; YI Jun-lin; LUO Jing-wei; HUANG Xiao-dong

    2012-01-01

    Background Local failure of nasopharyngeal carcinoma (NPC) after radiotherapy (RT) remains one of the major treatment failures.This study aimed to evaluate the clinical efficacy and complications of fractionated stereotactic radiotherapy (FSRT) with vagina carotica protection technique for local residual of NPC patients after the primary RT.Methods From August 2006 to August 2010,FSRT with vagina carotica protection technique was applied to 36 patients in our department,the patients aged between 13 and 76 years with a median of 41.3 years,25 of them were male and 11were female.According to 2002 Union for International Cancer Control (UICC) Staging System,the stages before primary radiotherapy were:Ⅱa 2,Ⅱb 5,Ⅲ 18,Ⅳa 7,Ⅳb 4.In the first course of radiotherapy,9 patients received conventional RT,27 patients received intensity modulated radiotherapy (IMRT) and 20 out of the 36 patients received concurrent chemoradiotherapy.The total dose in the first course of RT was 69.96-76.90 Gy (median,72.58 Gy).The intervals between the primary RT and FSRT ranged from 12 to 147 days (median,39.8 days).Target volumes ranged from 1.46 to 32.98 cm3 (median,14.94 cm3).The total FSRT doses were 10.0-24.0 Gy (median,16.5 Gy) with 2.0-5.0Gy per fraction.The most common regimen was 15 Gy in 5 fractions of 3 Gy,the irradiation dose to vagina carotica was less than 2 Gy per fraction.Results The median follow-up time was 34 months (range,12-59 months).The 3-year local control rate was 100%;the 3-year overall survival rate was 94.4%;the 3-year disease-free survival rate was 77.8%.In this study,we had one case of cranial nerve injury,two cases of temporal lobe necrosis,and no nasopharyngeal massive hemorrhage was observed.Conclusion FSRT with vagina carotica protection technique is an effective and safe RT regimen for local residual of NPC with reduction of radiation-related neurovascular lesions.

  14. Putting Women Back on Top?: (Re)constituting Power and Audience in The Vagina Monologues

    Gellert, Ashley Elizabeth

    2011-01-01

    Eve Enslerâ s goal in writing The Vagina Monologues was to generate a dialogue regarding womenâ s sexuality to counter the silence that pervades the patriarchal culture that they inhabit. To achieve this goal, Ensler constructs two ideologiesâ one grounded in patriarchy and another supposedly grounded in female agency and dialogueâ to reveal the problems within the current ideology in hopes that her audience will adopt her new ideology and resolve the detrimental silence women endure. T...

  15. Tubulosquamous polyps in the vagina. Immunohistochemical comparison with ectopic prostatic tissue and Skene glands.

    Roma, Andres A

    2016-06-01

    Two tubulosquamous polyps arising in the vagina are reported. Both were diffusely positive for GATA3 in the squamous component and focally positive for NKX3.1 in the glandular component, prostate acid phosphatase was focally positive in only 1 case in the glandular component. Both cases were negative for PAX2, PAX8, SALL4, and prostate-specific antigen. In addition, we included 3 cases of cervical squamous-lined cysts most likely representing ectopic prostatic tissue in the cervix and 1 case of paraurethral Skene-type glands to compare the immunophenotype. We analyze this immunoprofile, not previously reported. We also suggest unifying the nomenclature because vaginal Brenner tumors are most likely synonymous with tubulosquamous polyp (TSP) of the vagina. Our findings add support to the postulated origin of TSPs and cervical ectopic prostatic tissue from eutopic or misplaced Skene glands, equivalent of the prostate in the female. NKX3.1 seems a better marker to study and diagnose ectopic prostatic tissue in the cervix as well as TSPs. PMID:27180063

  16. [Primary peripheral T-cell lymphoma of the vagina incidentally found at cervical cancer screening].

    Isobe, Rei; Mituishi, Toshimi; Omote, Mayuko; Mori, Yuichi; Ida, Koichi; Oguchi, Osamu; Nakai, Ikuko; Oguchi, Masahiko

    2016-01-01

    A 50-year-old woman was referred to our hospital because a mass lesion had been palpable through the vaginal wall during a cervical cancer screening examination. A contrast-enhanced computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed marked thickening of the vaginal wall, constituting a mass 96 mm in diameter. Abnormal FDG uptake was observed in the vaginal mass, but no other lesions were detected by positron emission tomography (PET/CT). A transvaginal biopsy from the tumor revealed peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). Although endoscopic examinations revealed no signs of infiltration in either the bladder or the rectum, the MRI findings suggested invasion into the adjacent rectal wall. She achieved complete remission after six courses of biweekly THP-COP therapy, to which field radiation (39.6 Gy) was added. PTCL of the vagina is rare and this case therefore merits description in the literature. PMID:26861099

  17. Radiation therapy for primary squamous cell carcinoma of the vagina: Stanford University experience

    A retrospective analysis of 38 patients with primary squamous cell carcinoma of the vagina seen at Stanford University Medical Center from 1958 to 1984 was undertaken. Patients were analyzed with regard to symptoms, stage, treatment techniques, survival, patterns of failure, and complications. Eighteen patients were classified as FIGO Stage I, 5 as Stage II, 10 as Stage III, and 5 as Stage IV. The 5-year disease-free survival was 94% in Stage I, 80% in Stage II, 50% in Stage III, and 0% in Stage IV. Five patients (13%) had eight major complications secondary to treatment. Only 2 of 23 patients with Stage I or Stage II disease developed a recurrence. There was a significant correlation between dose and response in patients treated with radiotherapy

  18. Radicality of initial surgery for primary malignant melanoma of the vagina.

    Todo, Yukiharu; Okamoto, Kazuhira; Suzuki, Yoshihiro; Minobe, Shinichiro; Kato, Hidenori

    2016-04-01

    Radical surgery is considered not to improve the prognosis of primary malignant melanoma of the vagina (PMMV). This study was carried out to review the general consensus. A systematic review was performed on the basis of data from 10 patients in our cohort and 147 patients in the previous literature. The radicality of the initial surgery (RAINS) score was defined as the total number of points in terms of the resected organs. The target organs were the vagina, vulva, urethra, bladder, uterus, anus, rectum, pelvic lymph nodes, and inguinal lymph nodes. Overall survival (OS) according to the RAINS score was analyzed using the Kaplan-Meier method. Information on tumor stage, size, and depth of invasion was not obtained in 15, 47, and 43% of patients, respectively. The median follow-up period was 18 months. OS with a RAINS score of at least 7 was significantly longer than that with a RAINS score of up to 6 (median survival time, 41 vs. 19 months; log-rank test, P=0.037), despite the fact that the former group included significantly more patients with advanced-stage disease. A significant difference in OS was not found between patients with a RAINS score of at least 6 and up to 5. The therapeutic significance of radical surgery for PMMV has not been assessed appropriately in previous studies because of the lack of comparability among groups and differences in the definitions of surgical radicality. Patients with PMMV might benefit from initial surgery with appropriate surgical radicality, despite incomplete validation of the RAINS score. PMID:26825038

  19. Complete Genome Sequence of Lactococcus lactis subsp. lactis CV56, a Probiotic Strain Isolated from the Vaginas of Healthy Women▿

    Gao, Yong; Lu, Ying; Teng, Kun-Ling; Chen, Mei-Ling; Zheng, Hua-Jun; Zhu, Yong-Qiang; Zhong, Jin

    2011-01-01

    Lactic acid bacteria that exist in the urinogenital system play an important role in maintaining the health of the host. Here, we report the finished and annotated genome of a Lactococcus strain that was isolated from the vaginas of healthy women and shows probiotic properties, including nisin A production and adhesion to vaginal epithelial cells.

  20. Absence of a vagina and right sided adnexa uteri in the Waardenburg syndrome: a possible clue to the embryological defect.

    Goodman, R M; Oelsner, G; Berkenstadt, M; Admon, D.

    1988-01-01

    An 18 year old single Jewish woman with the Waardenburg syndrome and absence of a vagina and right sided adnexa uteri is reported. Other congenital malformations associated with the Waardenburg syndrome are mentioned and it is postulated that they may be the result of an altered invasion of neurones or altered neurones in certain organ systems early in embryogenesis.

  1. De betrouwbaarheid van het vagina-uitstrijkje van de rat als middel om de fase van de bronstcyclus te detecteren

    van Velsen FL; Loeber JG; Franken MAM; Liefde AD

    1985-01-01

    De betrouwbaarheid van het vagina-uitstrijkje bij de rat als indicator van de fase van de cyclus is onderzocht bij 60 dieren van 250 g. Gedurende 4 achtereenvolgende weken is op de werkdagen een uitstrijkje gemaakt ter beoordeling van de regelmaat van de cyclus. Daarna zijn de dieren geseceerd na d

  2. Reconstruction of the anus, rectovaginal septum, and distal part of the vagina after postirradiation necrosis. Report of a unique case

    Successful repair of postirradiation total loss of the anal sphincters, rectovaginal septum, and distal part of the vagina is reported. Gracilis muscle flap was used as a substitute sphincter. Part of the muscle was wrapped-up in a split skin graft. To the authors' knowledge, this is the first report on new application of gracilis muscle and split skin graft in perineal reconstruction

  3. Recurrent paediatric pinworm infection of the vagina as a potential reservoir for Enterobius vermicularis.

    Kashyap, B; Samantray, J C; Kumar, S; Jhamb, R; Singh, A K; Kaur, I R

    2014-09-01

    Enterobius vermicularis infection remains one of the most common parasitic infections, particularly prevalent in children. Enterobiasis, although not usually dangerous, may cause significant morbidity. Elimination of the parasite from a family or an institution often poses problems, either because of an incomplete cure or re-infection. While there have been limited reports of ectopic enterobiasis throughout the world, ours is probably one of the rarest reports of recurrent vaginal E. vermicularis infection in the absence of any gastrointestinal symptoms despite complete treatment. A 4-year-old girl presented with recurrent episodes of vulval itching on 3-4 occasions over 2 years. There was no pruritis ani nor urinary/gastrointestinal complaints. The vulva was inflamed with 4-5 living worms, 6-7 mm in length, emerging from the anterior vaginal fornix, but with no vaginal discharge. Direct microscopic examination of vaginal swabs revealed adult worms of Enterobius but no eggs. Repeated stool samples from the patient, parents and a sibling were negative. The patient was treated orally with 100 mg of mebendazole for 3 days followed by two more courses at 3-week intervals over a period of 3 months. Recurrent vaginal enterobiasis despite complete treatment and in the absence of any gastrointestinal involvement suggests that the vagina is a potential reservoir for E. vermicularis, which supports the theory of rare ectopic enterobiasis through the ascending pathway of the female genital tract. PMID:23721910

  4. Perivascular epithelioid cell tumour of the vagina in an 8 year old girl.

    Ong, Lin Yin; Hwang, Wei Sek; Wong, Adelina; Chan, Mei Yoke; Chui, Chan Hon

    2007-03-01

    Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal tumor with an unpredictable natural history. We present the first reported case of PEComa of the vagina diagnosed in an 8-year-old girl. This was initially diagnosed on biopsy as an embryonal rhabdomyosarcoma, and the patient underwent 3 cycles of chemotherapy according to the Mesenchymal Malignant Tumour 1989 protocol. A repeat scan, however, revealed an increase in tumor size. Total resection was achieved via a transvaginal (vertical sleeve) partial vaginectomy. The resected tumor had the typical appearance of a PEComa. Immunostains showed positive staining of tumor cells for HMB45, neuron-specific enolase, and calponin but were negative for S100 protein, melaninA, chromogranin, smooth muscle actin, desmin, caldesmon, epithelial membrane antigen, AE1/3, and synaptophysin. Six months after surgery, she remains free of tumor and is on follow-up with regular local examinations under anesthesia and computed tomography scans. Our case highlights the importance of an accurate initial diagnosis, and we stress the importance of regular surveillance over a significant period. PMID:17336201

  5. [Streptococcus agalactiae (GBS)--the characteristic of isolated strains from productive women's vagina].

    Wolny, Katarzyna; Gołda-Matuszak, Ewa

    2010-01-01

    The main aim of my research: to determine the frequency of colonisation Streptococcus agalactiae from productive women's vagina, an evaluation of usefulness microbiological diagnostic methods to detect GBS, to define serotype of analysed strains of S. agalactiae. After all, I tried to define fenotypic differential, biochemical and antimicrobial susceptibility between GBS with and without hemolysis. All of strains S. agalactiae (n = 380) belong to bacteria Gram(+), they had B serologic group and didn't produce catalase. On the basis of TSA+5% sheep blood streptococcus with beta-hemolysis grew like a small, grey and shiny colonies with a narrow, bright ring. On the same base we had S. agalactiae without beta-hemolysis, in examine material--6% (n = 22). On the basis of Strepto B ID S. agalactiae grew like a small, round red colonies and on the base Granada agar like an orange, white colonies. The level of colonisation S. agalactiae was 22% (380GBS/1727women). Identification of analysed strains of S. agalactiae was made by test API 20 Strep. The susceptibility was examined to ampicilin, azithromycin, erythromycin, clindamycin, chloramphenicol, doxycyclin, cotrimoxasol, ciprofloxacin. Serotypes III (50%), Ia (18%) and V (14%) prevailed. PMID:20873487

  6. Estudio de micoplasmas y bacterias aerobias en la vagina craneal de hembras caninas clínicamente sanas

    Stornelli, María Alejandra; Cerdá, Raúl Oscar; Gobello, Cristina; Arauz, María Sandra; Stanchi, Néstor Oscar

    2000-01-01

    La flora bacteriana presente en la vagina de hembras caninas posee un discutido rol en las enfermedades reproductivas de esta especie, por lo tanto y para contribuir al esclarecimiento de este aspecto, se realizó un estudio de los microorganismos vaginales en 33 perras sanas. Las muestras fueron tomadas mediante hisopo cubierto y procesadas siguiendo las marchas bacteriológicas indicadas para bacterias aerobias y Micoplasmas. Se aislaron microorganismos a partir de 30 muestras, siendo 3 negat...

  7. A RARE C.T. SCAN FINDING OF FOREIGN BODY VAGINA, A HARD FRUIT, KEPT AS PESSARY FOR UTERINE PROLAPSE

    Radha Rani

    2014-06-01

    Full Text Available Vaginal pessaries still have a role in the management of uterine prolapse, particularly in elderly patients. The presence of a foreign body or device in the female pelvis can be a potential source of confusion to the radiologists, particularly to the inexperienced reader. We present a rare C.T. scan finding of a hard fruit kept in vagina 5yrs back for uterine prolapse.

  8. Characterisation of the bacterial microbiota of the vagina of dairy cows and isolation of pediocin-producing Pediococcus acidilactici

    Wang Yvonne; Ametaj Burim N; Ambrose Divakar J; Gänzle Michael G

    2013-01-01

    Abstract Background Uterine infections in dairy cows lower profitability of dairy operations. Infections of the reproductive tract are related to the overgrowth of pathogenic bacteria during the first three weeks after parturition. However, alterations in the vaginal microbiota composition in the first weeks after parturition remain poorly documented. Results In this study, bacteria isolated from the vagina of healthy pregnant, and infected postpartum cows were characterised by random amplifi...

  9. In vivo Raman spectroscopy of human uterine cervix: exploring the utility of vagina as an internal control

    Shaikh, Rubina; Dora, Tapas Kumar; Chopra, Supriya; Maheshwari, Amita; Kedar K., Deodhar; Bharat, Rekhi; Krishna, C. Murali

    2014-08-01

    In vivo Raman spectroscopy is being projected as a new, noninvasive method for cervical cancer diagnosis. In most of the reported studies, normal areas in the cancerous cervix were used as control. However, in the Indian subcontinent, the majority of cervical cancers are detected at advanced stages, leaving no normal sites for acquiring control spectra. Moreover, vagina and ectocervix are reported to have similar biochemical composition. Thus, in the present study, we have evaluated the feasibility of classifying normal and cancerous conditions in the Indian population and we have also explored the utility of the vagina as an internal control. A total of 228 normal and 181 tumor in vivo Raman spectra were acquired from 93 subjects under clinical supervision. The spectral features in normal conditions suggest the presence of collagen, while DNA and noncollagenous proteins were abundant in tumors. Principal-component linear discriminant analysis (PC-LDA) yielded 97% classification efficiency between normal and tumor groups. An analysis of a normal cervix and vaginal controls of cancerous and noncancerous subjects suggests similar spectral features between these groups. PC-LDA of tumor, normal cervix, and vaginal controls further support the utility of the vagina as an internal control. Overall, findings of the study corroborate with earlier studies and facilitate objective, noninvasive, and rapid Raman spectroscopic-based screening/diagnosis of cervical cancers.

  10. Antagonistic Potential against Pathogenic Microorganisms and Hydrogen Peroxide Production of Indigenous Lactobacilli Isolated from Vagina of Chinese Pregnant Women

    HENG-YI XU; WAN-HONG TIAN; CUI-XIANG WAN; LI-JUN JIA; LAN-YIN WANG; JING YUAN; CHUN-MEI LIU; MING ZENG; HUA WEI

    2008-01-01

    Objective To investigate the indigenous lactobacilli from the vagina of pregnant women and to screen the isolates with antagonistic potential against pathogenic microorganisms. Methods The strains were isolated from pregnant women's vagina and identified using the APISOCH system. The ability of the isolates to produce hydrogen peroxide was analyzed semi-quantitatively using the TMB-HRP-MRS agar. The antagonistic effects of the isolates on pathogenic microorganisms were determined with a double layer agar plate. Results One hundred and three lactobacilli strains were isolated from 60 samples of vaginal secretion from healthy pregnant women. Among them, 78 strains could produce hydrogen peroxide, in which 68%, 80%, 80%, and 88% had antagonistic effects against Candida albicans CMCC98001, Staphylococcus aureus CMCC26003, Escherichia coli CMCC44113, and Pseudomonas aeruginosa CMCC10110, respectively. Conclusion The recovery of hydrogen peroxide-producing lactobacilli decreases with the increasing pregnant age and time. The most commonly isolated species from vagina of Chinese pregnant women are Lactobacillus acidophilus and Lactobacillus crispatus. Most of L. Acidophilus and L. Crispatus produce a high H2O2 level.

  11. Delivery of double singleton pregnancies in a woman with a double uterus, double cervix, and complete septate vagina.

    Yang, Ming-Jie; Tseng, Jen-Yu; Chen, Chih-Yao; Li, Hsin-Yang

    2015-12-01

    Uterine anomalies involving a double uterus, double cervix, also known as didelphys uterus, and complete septate vagina are rarely seen and have an associated fertility problem. However, artificial reproductive technology with embryo transfers can help solve this fertility challenge. Conception in the uterus in just one side is commonly seen for embryos, which are always transferred through the usually used (dilated) vagina. We here present a patient with the above uterine anomaly who conceived with the aid of in vitro fertilization and embryo transfer to both uterine cavities under general anesthesia, which resulted in successful double singleton pregnancies with one fetus in each uterus. With intensive prenatal care, the pregnancy course for each fetus was rather uneventful. Although both fetuses were in cephalic presentation, cesarean section was performed at the 39(th) week of gestation with good outcomes in order to preclude anticipated difficulties if the baby had been delivered through the rarely dilated vagina. However, order of birth between the two fetuses was a crucial decision during the operation. PMID:26462956

  12. Unravelling the Bacterial Vaginosis-Associated Biofilm: A Multiplex Gardnerella vaginalis and Atopobium vaginae Fluorescence In Situ Hybridization Assay Using Peptide Nucleic Acid Probes

    Hardy, Liselotte; Jespers, Vicky; Dahchour, Nassira; Mwambarangwe, Lambert; Musengamana, Viateur; Vaneechoutte, Mario; Crucitti, Tania

    2015-01-01

    Bacterial vaginosis (BV), a condition defined by increased vaginal discharge without significant inflammation, is characterized by a change in the bacterial composition of the vagina. Lactobacillus spp., associated with a healthy vaginal microbiome, are outnumbered by BV-associated organisms. These bacteria could form a polymicrobial biofilm which allows them to persist in spite of antibiotic treatment. In this study, we examined the presence of Gardnerella vaginalis and Atopobium vaginae in ...

  13. Effect of semen collection method (artificial vagina vs. electroejaculation), extender and centrifugation on post-thaw sperm quality of Blanca-Celtibérica buck ejaculates

    Jiménez Rabadán, Pilar; Ramón, Manuel; García Alvarez, Olga; Maroto Morales, Alejandro; Olmo, Enrique del; Pérez Guzmán, María Dolores; Bisbal, A.; Fernández Santos, María del Rocío; Garde López-Brea, José Julián; Soler, Ana Josefa

    2012-01-01

    The aim of this study was to evaluate the effect of semen collection method (artificial vagina compared to electroejaculation), season in which the semen was collected (breeding season compared to non-breeding season), freezing extender (Biladyl®, Andromed® and skim milk based extender) and pre-treatment procedure (washing compared to non-washing) on post-thaw semen quality in buck. Ejaculates from seven bucks of the Blanca-Celtibérica breed were collected by artificial vagina ...

  14. Unravelling the Bacterial Vaginosis-Associated Biofilm: A Multiplex Gardnerella vaginalis and Atopobium vaginae Fluorescence In Situ Hybridization Assay Using Peptide Nucleic Acid Probes.

    Liselotte Hardy

    Full Text Available Bacterial vaginosis (BV, a condition defined by increased vaginal discharge without significant inflammation, is characterized by a change in the bacterial composition of the vagina. Lactobacillus spp., associated with a healthy vaginal microbiome, are outnumbered by BV-associated organisms. These bacteria could form a polymicrobial biofilm which allows them to persist in spite of antibiotic treatment. In this study, we examined the presence of Gardnerella vaginalis and Atopobium vaginae in vaginal biofilms using Peptide Nucleic Acid (PNA probes targeting these bacteria. For this purpose, we developed three new PNA probes for A. vaginae. The most specific A. vaginae probe, AtoITM1, was selected and then used in an assay with two existing probes, Gard162 and BacUni-1, to evaluate multiplex FISH on clinical samples. Using quantitative polymerase chain reaction (qPCR as the gold standard, we demonstrated a sensitivity of 66.7% (95% confidence interval: 54.5% - 77.1% and a specificity of 89.4% (95% confidence interval: 76.1% - 96% of the new AtoITM1 probe. FISH enabled us to show the presence of a polymicrobial biofilm in bacterial vaginosis, in which Atopobium vaginae is part of a Gardnerella vaginalis-dominated biofilm. We showed that the presence of this biofilm is associated with high bacterial loads of A. vaginae and G. vaginalis.

  15. Unravelling the Bacterial Vaginosis-Associated Biofilm: A Multiplex Gardnerella vaginalis and Atopobium vaginae Fluorescence In Situ Hybridization Assay Using Peptide Nucleic Acid Probes.

    Hardy, Liselotte; Jespers, Vicky; Dahchour, Nassira; Mwambarangwe, Lambert; Musengamana, Viateur; Vaneechoutte, Mario; Crucitti, Tania

    2015-01-01

    Bacterial vaginosis (BV), a condition defined by increased vaginal discharge without significant inflammation, is characterized by a change in the bacterial composition of the vagina. Lactobacillus spp., associated with a healthy vaginal microbiome, are outnumbered by BV-associated organisms. These bacteria could form a polymicrobial biofilm which allows them to persist in spite of antibiotic treatment. In this study, we examined the presence of Gardnerella vaginalis and Atopobium vaginae in vaginal biofilms using Peptide Nucleic Acid (PNA) probes targeting these bacteria. For this purpose, we developed three new PNA probes for A. vaginae. The most specific A. vaginae probe, AtoITM1, was selected and then used in an assay with two existing probes, Gard162 and BacUni-1, to evaluate multiplex FISH on clinical samples. Using quantitative polymerase chain reaction (qPCR) as the gold standard, we demonstrated a sensitivity of 66.7% (95% confidence interval: 54.5% - 77.1%) and a specificity of 89.4% (95% confidence interval: 76.1% - 96%) of the new AtoITM1 probe. FISH enabled us to show the presence of a polymicrobial biofilm in bacterial vaginosis, in which Atopobium vaginae is part of a Gardnerella vaginalis-dominated biofilm. We showed that the presence of this biofilm is associated with high bacterial loads of A. vaginae and G. vaginalis. PMID:26305575

  16. Seminal plasma protein profiles of ejaculates obtained by internal artificial vagina and electroejaculation in Brahman bulls.

    Rego, J P A; Moura, A A; Nouwens, A S; McGowan, M R; Boe-Hansen, G B

    2015-09-01

    The present study was conducted to investigate if differences exist in the seminal plasma protein profile from mature Brahman bulls using two methods of semen collection: internal artificial vagina (IAV) and electroejaculation (EEJ). Semen was collected four times from three bulls on the same day and parameters were assessed immediately post-collection. Seminal plasma proteins were evaluated by 2-D fluorescence difference gel electrophoresis and identified by mass spectrometry. Semen volume was greater (P < 0.05) for EEJ (4.6 ± 0.35 mL) than for IAV (1.86 ± 0.24 mL) but sperm concentration was greater in IAV (1505 ± 189 × 10(6) sperm/mL) than in EEJ samples (344 ± 87 × 10(6) sperm/mL). Sperm motility and the percentage of normal sperm were not different between treatments. Total concentration of seminal plasma proteins was greater for samples collected by IAV as compared to EEJ (19.3 ± 0.9 compared with 13.0 ± 1.8 mg/mL, P < 0.05; respectively). Based on 2-D gels, 22 spots had a greater volume (P < 0.05) in gels derived from IAV samples, corresponding to 21 proteins identified as transferrin, albumin, epididymal secretory glutathione peroxidase, among others. Thirty-three spots, corresponding to 26 proteins, had a greater volume (P < 0.05) in gels derived from EEJ samples. These proteins were identified as spermadhesin-1, Bovine Sperm Protin 1, 3 and 5 isoforms, angiogenin-1, alpha-1B-glycoprotein, clusterin, nucleobindin-1, cathepsins, spermadhesin Z13, annexins, among others. Thus, proteins in greater amounts in samples obtained by IAV and EEJ were mainly of epididymal origin and accessory sex glands, respectively. PMID:26282524

  17. Clinical Holistic Medicine: Holistic Sexology and Acupressure Through the Vagina (Hippocratic Pelvic Massage

    Søren Ventegodt

    2006-01-01

    Full Text Available Many gynecological and sexological problems (like urine incontinence, chronic pelvic pains, vulvodynia, and lack of lust, excitement, and orgasm are resistant to standard medical treatment. In our work at the Research Clinic for Holistic Medicine in Copenhagen, we have found that vaginal acupressure, or Hippocratic pelvic massage, can help some of these problems. Technically, it is a very simple procedure as it corresponds to the explorative phase of the standard pelvic examination, supplemented with the patient's report on the feelings it provokes and the processing and integration of these feelings. Sometimes it can be very difficult to control the emotions released by the technique, i.e., regression to earlier traumas from childhood sexual abuse. This review discusses the theory behind vaginal acupressure, ethical aspects, and presentation of a case story. This procedure helped the patient to become present in her pelvis and to integrate old traumas with painful emotions. Holistic gynecology and sexology can help the patient to identify and let go of negative feelings, beliefs, and attitudes related to sex, gender, sexual organs, body, and soul at large. Shame, guilt, helplessness, fear, disgust, anxiety, anger, hatred, and other strong feelings are almost always an important part of a sexual or functional problem as these feelings are “held” by the tissue of the pelvis and sexual organs. Acupressure through the vagina/pelvic massage must be done with great care by an experienced physician, with a third person present, after obtaining consent and the necessary trust of the patient. It must be followed by conversational therapy and further holistic existential processing.

  18. Self-assessment of anatomy, sexual sensitivity, and function of the labia and vagina.

    Schober, Justine M; Alguacil, Nieves Martin; Cooper, R Scott; Pfaff, Donald W; Meyer-Bahlburg, Heino F L

    2015-04-01

    Patient perceptions of genital esthetics are motivating requests for plastic surgeries that could change sexual sensitivity. There is little information about the sensitivities of labial and introital sites. The aim of this study is to assess the relationship between sexual sensitivity and self-reported sizes of labial and introital sites. Sixty-two healthy, sexually active, adult women (mean age 37.9, range 21-60) with no history of genital or vaginal surgery gave written consent to participate in this study. A modified version of Self-Assessment of Genital Anatomy and Sexual Function (L-SAGASF-F) was used to assess labial and introital size. Site-specific sensation was rated on Likert scales of 1-5. Anatomical locations were compared for ratings. Of 62 responders, 84% (52) described their labia as "average-sized," 11% (7) described their labia minora and 13% (8) their labia majora as "large", and 3% (2) and 5% (3) as "small". Sexual pleasure ratings were "moderate" (median value: 3.0 for external genitalia and vaginal lumen) or "strong" (median value: 4.0 for the interior vagina). Significantly higher rankings related to the vaginal opening (P=0.007). Orgasm intensity for stimulation of the external genitalia progressively increased toward the vaginal opening, from 1.0 to 3.0 (P=0.001); vaginal ratings showed a similar progression, from 2.0 at the external luminal margin to 3.0 in the deep interior (P<0.0001). Orgasm effort scores were intermediate (median: 3.0), uniform throughout the external and internal areas (P=0.626). Ratings for labial and introital sensitivity, regardless of self-reported size, were very similar to those at other genital sites for sexual pleasure. Surgical excision of labial and introital structures could modify sexual sensation. PMID:25683213

  19. 阴道平滑肌瘤25例临床分析%Clinical analysis of 25 cases of leiomyoma of the vagina

    钱建华; 郑斐; 石一复

    2001-01-01

    目的 探讨阴道平滑肌瘤的组织来源、临床特点和治疗方法。方法 回顾性分析1988年1月~1999年1月在我院住院手术并经病理检查证实的阴道平滑肌瘤25例。结果 阴道平滑肌瘤多为单发,生长缓慢,症状与肿瘤的大小及部位有关,可复发及恶性变。治疗方式为阴道平滑肌瘤剔除术。结论 阴道平滑肌瘤临床少见,一旦发现,均应及时手术治疗,以免肌瘤增大产生症状甚至恶性变。%Objective To study the histologic source, clinical features and treatment methods of leiomyoma of the vagina. Methods From January of 1988 to January of 1999, 25 patients with leiomyoma of the vagina were retrospectively analyzed. Results The clinical features of leiomyoma of the vagina were slow in growth and solitary in number. Leiomyoma of the vagina can be recurrence and sarcomatous change. The symptoms of leiomyoma of the vagina depended on the size and location of the leiomyoma. Treatment consisted of surgical excision by vagina. Conclusions Leiomyoma of the vagina is a rare condition. Whenever such a tumor is detected, it has to be removed immediately to prevent further growing and sarcomatous change in the future.

  20. Bladder cancer will grow anywhere: report of a urothelial carcinoma drop metastasis to the vagina and literature review.

    Uhlman, Matthew A; Bevill, Mark D; Goodheart, Michael J; Brown, James A; O'Donnell, Michael A

    2016-08-01

    Urothelial carcinoma is the 2nd most common cancer of the urinary tract and accounts for the majority of cases of bladder cancer. Metastases are not infrequently encountered, increasing with disease stage and are most commonly seen in the bones and lungs. Many other sites have been described including the omentum, liver, and ovaries. An extremely rare site of metastatic disease however is within the vagina. Here we present a case of a probable vaginal 'drop metastasis' from previously treated urothelial carcinoma in the ureter and bladder. PMID:27544563

  1. Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina; Avaliacao dosimetrica de uma combinacao de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porcao distal da vagina

    Guimaraes, Roger Guilherme Rodrigues [Real e Benemerita Sociedade Portuguesa de Beneficencia, Sao Paulo, SP (Brazil). Servico de Radioterapia Estereotactica; Carvalho, Heloisa de Andrade; Stuart, Silvia Radwanski; Rubo, Rodrigo Augusto [Universidade de Sao Paulo (USP), SP (Brazil). Hospital das Clinicas. Servico de Radioterapia], e-mail: handrade@hcnet.usp.br; Seraide, Rodrigo Migotto [Centro de Oncologia Campinas, SP (Brazil)

    2009-07-15

    Objective: To evaluate an alternative brachytherapy technique for uterine cervix cancer involving the distal vagina, without increasing the risk of toxicity. Materials And Methods: Theoretical study comparing three different high-dose rate intracavitary brachytherapy applicators: intrauterine tandem and vaginal cylinder (TC); tandem/ring applicator combined with vaginal cylinder (TR+C); and a virtual applicator combining both the tandem/ring and vaginal cylinder in a single device (TRC). Prescribed doses were 7 Gy at point A, and 5 Gy on the surface or at a 5 mm depth of the vaginal mucosa. Doses delivered to the rectum, bladder and sigmoid colon were kept below the tolerance limits. Volumes covered by the isodoses, respectively, 50% (V50), 100% (V100), 150% (V150) and 200% (V200) were compared. Results: Both the combined TR+C and TRC presented a better dose distribution as compared with the TC applicator. The TR+C dose distribution was similar to the TRC dose, with V150 and V200 being about 50% higher for TR+C (within the cylinder). Conclusion: Combined TR+C in a two-time single application may represent an alternative therapy technique for patients affected by uterine cervix cancer involving the distal vagina. (author)

  2. Definitive radiotherapy for carcinoma of the vagina: outcome and prognostic factors

    Purpose: Primary carcinoma of the vagina is an uncommon tumor. Because of the long-standing interest in this disease at our institution a substantial number of patients with this disease has been accumulated, and this retrospective review was performed to define disease outcome, to delineate significant prognostic factors, and to provide treatment guidelines. Methods and Materials: This was a retrospective review of 301 patients with vaginal carcinoma (271 with squamous cell and 30 with adenocarcinoma) who received definitive radiotherapy between 1953 and 1991. Prognostic factors for outcome (local control, pelvic control, metastatic relapse, survival, and complications) were evaluated using univariate and multivariate techniques. Results: Patients disease was staged using the International Federation of Gynecology and Obstetrics (FIGO) system, and stages were distributed as follows: 0, 37 (12%); I, 65 (22%); II, 122 (40%); III, 60 (20%); and, IVA, 17 (6%). Treatment varied according to stage, with brachytherapy predominating for early disease but external beam playing a prominent role for more advanced disease. Patients with in situ disease received brachytherapy alone or transvaginal orthovoltage irradiation. For Stage I, brachytherapy alone was used in 25, external beam and brachytherapy in 38, and transvaginal alone in 2. For Stage II, brachytherapy alone was used in 20, external and brachytherapy in 66, and external irradiation alone in 36. For Stage III, external and brachytherapy was used in 15, and external alone in 45. Two patients with Stage IVA received brachytherapy alone, 10 received a combination of external and brachytherapy, and 6 received external irradiation alone. Total doses ranged from 10 to 154 Gy (mean 74.7 Gy, median 70.0 Gy), but only 18 (6%) received less than 55 Gy. At a median follow-up of 13 years, the 5-, 10-, 15-, 20-, and 25-year survival rates were 60%, 49%, 38%, 29%, and 23%, respectively. Beyond 5 years the survival rates relative

  3. Effect of seminal plasma on post-thaw quality and functionality of corriedale ram sperm obtained by electroejaculation and artificial vagina.

    Ledesma, A; Manes, J; Ríos, G; Aller, J; Cesari, A; Alberio, R; Hozbor, F

    2015-06-01

    We have already shown that seminal collection method affects seminal plasma composition and sperm quality in Corriedale rams. In this study, we evaluated the effect of seminal plasma collected by electroejaculation or artificial vagina on sperm resistance to cryodamage. Seminal plasma of five rams of the Corriedale breed collected by artificial vagina or electroejaculation was added before freezing to sperm cells collected by the two methods, and post-thaw quality parameters were evaluated. We found that seminal plasma has no effect on sperm resistance to cryodamage. However, we observed significantly higher percentages of sperm with intact and functional plasma membrane, intact acrosome and greater fertilizing potential after thawing in samples obtained by electroejaculation. This study demonstrates that sperm collected by electroejaculation are more resistant to damage caused by cryopreservation than those collected by artificial vagina. PMID:25684063

  4. Ultrastructural study of the neovagina following the utilization of human amniotic membrane for treatment of congenital absence of the vagina

    L.F. Bleggi-Torres

    1997-07-01

    Full Text Available We present an ultrastructural study of the utilization of human amniotic membrane in the treatment of congenital absence of the vagina in 10 patients. All patients were surgically treated with application of an amniotic membrane graft using the modified McIndoe and Bannister technique. Sixty days after surgery, samples of the vaginal neo-epithelium were collected for transmission electron microscopy analysis. The ultrastructural findings consisted of a lining of mature squamous epithelium indicating the occurrence of metaplasia of the amniotic epithelium into the vaginal epithelium. The cells were arranged in layers as in the normal vaginal epithelium, i.e., superficial, intermediate and deep layers. There were desmosomes and cytoplasmic intermediate cytokeratin filaments, as well as some remnant features of the previous amniotic epithelium. These findings suggest that human amniotic membrane is able to complete metaplasia into squamous cells but the mechanism of this cellular transformation is unknown

  5. Analysis of study rezults of biopsies of the vagina mucous membrane in women with recurrent genital prolapse

    Banakhevich R.M.

    2014-06-01

    Full Text Available The study involved 53 women with recurrent genital prolapse. The average age of the women studied was 62,8±9,8 years, age of women of the control group was 57,2±6,3 years (p>0,05. Features of expression of estrogen and progesterone receptors levels, markers of cell proliferation and collagen in the biopsy of the vagina mucous membrane were estimated. In the vaginal mucosa of patients with recurrent prolapse expression of Ki-67 markers of proliferative activity was not established. According to the study general lowering of estrogen receptors by 76,2% in patients with recurrent genital prolapse was established, whereas in patients of the control group level of estrogen receptors in the unchanged epithelium and stroma was positive in 100% of cases. In patients with recurrent genital prolapse the decrease of expression of progesterone receptors by 83,4% was identified.

  6. Ultrastructural features of vagina at different phases of the oestrous cycle in the female African giant rat (Cricetomys gambianus Waterhouse).

    Akinloye, Adebayo K; Oke, Bankole O

    2014-06-01

    The ultrastructures of the vagina at various stages of the oestrous cycle in female African giant rats (Cricetomys gambianus Waterhouse) were described in the present study. At mid-proestrus, late proestrus (LP)/early estrus (EE) and mid-estrus (ME) as well as late metestrus (LM)/early diestrus (ED) and mid-diestrus (MD), complex interface of epithelium and lamina propria were observed. Cells of the stratum basale formed finger-like extensions into the underlying lamina propria and tips of the extensions displayed hemidesmosome while basal lamina followed the contour of the extensions. At mid-metestrus (MM) and late diestrus/early proestrus, well developed, relatively straight basal lamina interfaced between the stratum basale and the lamina propria without finger-like projections. Polygonal cells with indented nuclei and, cytoplasm containing ribosomes, polysomes, intermediate filaments, and mitochondria were observed in stratum spinosum at all the phases of the oestrus cycle. At MM, LM/ED, and MD, the stratum spinosum had numerous desmosomes with tonofilaments, large microvilli that intermingled at the intercellular spaces and evidence of trapped/migrating neutrophils and lymphocytes. The superficial layer displayed short microvilli at mid-proestrus, cornification at LP/EE and desquamation at ME while it showed condensation of intermediate filaments; projections of large microvilli into the luminal surface at MM, and embeddement of neutrophils at LM/ED as well as MD. This study looked into the reproductive biology of female African giant rats to produce baseline information on its reproductive organs and represented the first comprehensive description of the vagina at the ultrastructural level during oestrous cycle. PMID:24737725

  7. Nonoxynol-9 berberine plural gel has little effect on expression of SLPI, SP-D and lactoferrin in mice’s vagina

    Huang Guangying

    2013-01-01

    Full Text Available Background: The most frequently used spermicide Nonoxynol-9 (N-9 in the clinic alters the vaginal flora, which will result in an increased risk of opportunistic infection. So development of a novel spermicidal and microbicidal drug appears to be inevitable. Vaginal local immune is an important part of vaginal flora. Secretory leukocyte protease inhibitor (SLPI, surfactant proteins D (SP-D, and lactoferrin (LF are anti-microbial molecules with important roles in immune system of female vaginas. Objective: To observe effect of a vaginal spermicide nonoxynol-9 (N-9 berberine plural gel on the expression of SLPI SP-D and LF in mice’s vaginas. Materials and Methods: Female BABL/C mice were randomly divided into following 5 groups: normal control group, blank gel group, berberine gel group, 12% N-9 gel group and N-9 berberine plural gel group. Estradiol benzoate at physiological dose was done by hypodermic injection to every group’s mice. After 72h, drug gels were separately injected into the mice’s vaginas, while immunohistochemistry and Western blot were taken to detect the expression of the 3 indexes in mice’s vaginas respectively after 24h and 72h of gel injection. Results: The differences in the three indexes between normal control group and blank gel group were not significant statistically (p>0.05. The expression of the three indexes in 12% N-9 gel group was decreased compared to that in blank gel group (p0.05. Also, the three index's level of 24h and 72h in sub observation groups after treatment were without statistical significance (p>0.05. Conclusion: Application of N-9 berberine plural gel had little impact on antimicrobial peptides in normal mice’s vaginas.

  8. Rapidly disintegrating vagina retentive cream suppositories of progesterone: development, patient satisfaction and in vitro/in vivo studies.

    Bendas, Ehab Rasmy; Basalious, Emad B

    2016-05-01

    Our objective was to develop novel vagina retentive cream suppositories (VRCS) of progesterone having rapid disintegration and good vaginal retention. VRCS of progesterone were prepared using oil in water (o/w) emulsion of mineral oil or theobroma oil in hard fat and compared with conventional vaginal suppositories (CVS) prepared by hard fat. VRCS formulations were tested for content uniformity, disintegration, melting range, in vitro release and stability studies. The most stable formulation (VRCS I) was subjected to scaling-up manufacturing and patients' satisfaction test. The rapid disintegration, good retentive properties are applicable through the inclusion of emulsified theobroma oil rather than hydrophilic surfactant into the hard fat bases. The release profile of progesterone from VRCS I showed a biphasic pattern due to the formation of progesterone reservoir in the emulsified theobroma oil. All volunteers involved in patients' satisfaction test showed high satisfactory response to the tested formulation (VRCS). The in vivo pharmacokinetic study suggests that VRCS of progesterone provided higher rate and extent of absorption compared to hard fat based suppositories. Our results proposed that emulsified theobroma oil could be promising to solve the problems of poor patients' satisfaction and variability of drug absorption associated with hard fat suppositories. PMID:25567033

  9. Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae.

    Verstraelen, Hans; Verhelst, Rita; Nuytinck, Lieve; Roelens, Kristien; De Meester, Els; De Vos, Daniel; Van Thielen, Martine; Rossau, Rudi; Delva, Wim; De Backer, Ellen; Vaneechoutte, Mario; Temmerman, Marleen

    2009-01-01

    Host genetic factors have previously been found to act as determinants of differential susceptibility to major infectious diseases. It is less clear whether such polymorphisms may also impose on pathogen recognition in mucosal overgrowth conditions such as bacterial vaginosis, an anaerobic overgrowth condition characterised by the presence of a vaginal biofilm consisting of the Gram-positive anaerobes Gardnerella vaginalis and Atopobium vaginae. We selected 34 single nucleotide polymorphisms pertaining to 9 genes involved with Toll-like receptor-mediated pathogen recognition and/or regulation (LBP, CD14, TLR1, TLR2, TLR4, TLR6, MD2, CARD15 and SIGIRR) and assessed in a nested case-control study their putative association with bacterial vaginosis, as diagnosed by Gram staining, and with the vaginal carriage of A. vaginae and G. vaginalis, as determined by species-specific PCR, among 144 pregnant women. Carriage of G. vaginalis during early pregnancy was associated with the -1155A>G substitution in the promoter region of the MD2 gene (p=0.041). The presence of A. vaginae during the first half of the pregnancy was significantly associated with the CD14 intron 2 1342G>T (p=0.039), the TLR1 exon 4 743A>G (p=0.038), and the CARD15 exon 4 14772A>T (p=0.012) polymorphisms, and marginally significantly associated with the LBP exon13 26842C>T (p=0.056), the CD14 promoter -260C>T (p=0.052), and the TLR1 promoter -7202A>G (p=0.062) polymorphisms. However, no association between gene polymorphisms and bacterial vaginosis as such could be documented. Our data suggest that some degree of genetic susceptibility involving pathogen recognition may occur with the key bacterial vaginosis organism, A. vaginae. PMID:19200604

  10. Persistence of Lactobacillus fermentum RC-14 and Lactobacillus rhamnosus GR-1 but Not L. rhamnosus GG in the Human Vagina as Demonstrated by Randomly Amplified Polymorphic DNA

    Gardiner, Gillian E.; Heinemann, Christine; Bruce, Andrew W.; Beuerman, Dee; Reid, Gregor

    2002-01-01

    Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 are well-characterized probiotic strains with efficacy in the prevention and treatment of urogenital infections in women. The aim of the present study was to apply a molecular biology-based methodology for the detection of these strains and L. rhamnosus GG (a commercially available intestinal probiotic) in the human vagina in order to assess probiotic persistence at this site. Ten healthy women inserted vaginally a capsule containing either ...

  11. 非培养法检测阴道微生态的进展%Research Progress of Detecting Vagina Microecology by Cultivation-Independent Methods

    陈晴

    2012-01-01

    女性阴道内寄生着多种微生物,鉴定阴道中存在的微生物有助于了解其在健康和疾病时的作用,但是许多微生物难以通过培养将其分离鉴定.近年来,一系列分子生物学的方法,如基于16S rRNA基因聚合酶链反应扩增法等用于研究阴道微生态并取得了较大的进展.利用分子生物学的非培养法检测女性阴道微生物发现,不论在健康女性还是细菌性阴道病(BV)患者中惰性乳杆菌是普遍存在的乳杆菌;还发现许多新的厌氧菌与BV高度相关,如阴道阿托波菌、阴道加德纳菌、BVAB1等.%The human vagina hosts many microbes. Identifying all kinds of microbes in vagina will help to better understand their roles in heath and disease. However,many microbes are difficult to be identified by cultivation-dependent methods. In recent years, a series of molecular approaches, such as PCR amplification of 16S rRNA gene,are used to study the vagina microecology and have made considerable progress. The use of molecular, cultivation-independent methods have revealed :lactobacillus inert is the ubiquitous nature in women with or without bacterial vaginosis( BV ); some novel anaerobes are strongly associated with BV, such as Atopobium vaginae, Gardnerella vaginalis, BVAB1 and so on.

  12. 25例先天性无阴道的手术治疗%Surgical treatment of 25 patients with congenital absence of vagina

    游艳琴; 宋磊; 李立安

    2012-01-01

    Objective To study the curative effect of surgical treatment on congenital absence of vagina. Methods Clinical data about 25 patients with congenital absence of vagina admitted to our hospital from 2006 to 2011 were retrospectively analyzed. Of these patients, 20 underwent vaginoplasty with acellulardermal repairing patch, 3 underwent vaginoplasty with peritoneum, and 2 underwent vaginoplasty with amniotic membrane. Results The vagina mucosa was formed in 19 patients 8 weeks after vaginoplasty with acellulardermal repairing patch and in 1 patient after vaginoplasty with peritoneum. The satisfactory rate of the patients for sexual life was 90%. Conclusion The time of vagina mucosa formation is relative short after vaginoplasty with acellulardermal repairing patch. The satisfactory rate of vaginoplasty with acellulardermal repairing patch is high, and the procedure deserves to be recommended.%目的 探讨先天性无阴道患者的手术疗效.方法 回顾性分析2006 年1 月-2011 年6 月我科就诊的25 例先天性无阴道患者的临床资料,20 例行脱细胞异体真皮补片人工阴道成形术,3 例行腹会阴联合腹膜代阴道成形术,2 例行羊膜代阴道成形术.结果 19 例脱细胞异体真皮补片人工阴道成形术和1 例腹膜阴道成形术者在术后8 周人工阴道完全黏膜化,性生活满意率为90%.结论 脱细胞异体真皮补片阴道成形术后阴道黏膜化时间短,满意率高,是一种值得推广的术式.

  13. Characterisation of the bacterial microbiota of the vagina of dairy cows and isolation of pediocin-producing Pediococcus acidilactici

    Wang Yvonne

    2013-01-01

    Full Text Available Abstract Background Uterine infections in dairy cows lower profitability of dairy operations. Infections of the reproductive tract are related to the overgrowth of pathogenic bacteria during the first three weeks after parturition. However, alterations in the vaginal microbiota composition in the first weeks after parturition remain poorly documented. Results In this study, bacteria isolated from the vagina of healthy pregnant, and infected postpartum cows were characterised by random amplification of polymorphic DNA (RAPD analysis and partial 16S ribosomal RNA (rDNA gene sequencing. Populations of bacilli and lactic acid bacteria of the genera Enterococcus, Lactobacillus, and Pediococcus were present in both healthy and infected cows. Infected cows had a significant increase in the vaginal enteric bacteria population which consisted mainly of Escherichia coli. Three E. coli isolates harboured the gene coding for Shiga-like-toxin (SLT I or II. Several isolates of the Pediococcus acidilactici were found to produce the bacteriocin pediocin AcH/PA-1. Quantitative PCR analyses of vaginal mucus samples collected from ten metritic cows before and after parturition confirmed the presence of the Lactobacillus group (Lactobacillus spp., Pediococcus spp., Leuconostoc spp., and Weissella spp.; Enterobacteriaceae, E. coli, and bacilli. The presence of the pediocin AcH/PA-1 structural gene and SLT genes were also confirmed with qPCR. Conclusions In conclusion, overgrowth of pathogenic bacteria, particularly E. coli, after parturition likely contributes to the development of metritis. Our microbiota analysis extends the information related to the composition of commensal bacteria in the bovine female reproductive tract and may facilitate the development of novel intervention strategies for prevention of uterine infections in dairy cows.

  14. Il Linguaggio della Vagina

    Marco Menicocci

    2011-01-01

    La cultura delle masse è oggi una cultura prevalentemente visuale. Tra i segni visuali da tempo in crescita è quello, caratteristico, della depilazione pubica femminile. Originata all'interno della cultura porno come segno di passività, questa pratica si è incontrata con i simboli della pulizia, dell'igiene, del rispetto, trasformando così il proprio significato in quello di autonomia e libertà. Così le donne possono depilarsi per scopi erotici minimizzando però la valenza sessuale del gesto ...

  15. Il Linguaggio della Vagina

    Marco Menicocci

    2011-12-01

    Full Text Available La cultura delle masse è oggi una cultura prevalentemente visuale. Tra i segni visuali da tempo in crescita è quello, caratteristico, della depilazione pubica femminile. Originata all'interno della cultura porno come segno di passività, questa pratica si è incontrata con i simboli della pulizia, dell'igiene, del rispetto, trasformando così il proprio significato in quello di autonomia e libertà. Così le donne possono depilarsi per scopi erotici minimizzando però la valenza sessuale del gesto tramite la tendenza alla super-igiene.

  16. Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis

    De Ganck Catharine

    2004-04-01

    Full Text Available Abstract Background The pathogenesis of bacterial vaginosis remains largely elusive, although some microorganisms, including Gardnerella vaginalis, are suspected of playing a role in the etiology of this disorder. Recently culture-independent analysis of microbial ecosystems has proven its efficacy in characterizing the diversity of bacterial populations. Here, we report on the results obtained by combining culture and PCR-based methods to characterize the normal and disturbed vaginal microflora. Results A total of 150 vaginal swab samples from healthy women (115 pregnant and 35 non-pregnant were categorized on the basis of Gram stain of direct smear as grade I (n = 112, grade II (n = 26, grade III (n = 9 or grade IV (n = 3. The composition of the vaginal microbial community of eight of these vaginal swabs (three grade I, two grade II and three grade III, all from non-pregnant women, were studied by culture and by cloning of the 16S rRNA genes obtained after direct amplification. Forty-six cultured isolates were identified by tDNA-PCR, 854 cloned 16S rRNA gene fragments were analysed of which 156 by sequencing, yielding a total of 38 species, including 9 presumptively novel species with at least five species that have not been isolated previously from vaginal samples. Interestingly, cloning revealed that Atopobium vaginae was abundant in four out of the five non-grade I specimens. Finally, species specific PCR for A. vaginae and Gardnerella vaginalis pointed to a statistically significant co-occurrence of both species in the bacterial vaginosis samples. Conclusions Although historically the literature regarding bacterial vaginosis has largely focused on G. vaginalis in particular, several findings of this study – like the abundance of A. vaginae in disturbed vaginal microflora and the presence of several novel species – indicate that much is to be learned about the composition of the vaginal microflora and its relation to the etiology of BV.

  17. Histopathologic Changes in the Uterus, Cervix and Vagina of Immature CD-1 Mice Exposed to Low Doses of Perfluorooctanoic Acid (PFOA) in a Uterotrophic Assay

    Dixon, Darlene; Reed, Casey E.; Moore, Alicia B.; Gibbs-Flournoy, Eugene A; Hines, Erin P.; Wallace, Elizabeth A.; Stanko, Jason P.; Lu, Yi; Jefferson, Wendy N.; Newbold, Retha R.; Fenton, Suzanne E.

    2011-01-01

    The estrogenic and antiestrogenic potential of perfluorooctanoic acid (PFOA) was assessed using an immature mouse uterotrophic assay and by histologic evaluation of the uterus, cervix and vagina following treatment. Female offspring of CD-1 dams were weaned at 18 days old and assigned to groups of equal weight, and received 0, 0.01, 0.1, or 1 mg PFOA/kg BW/d by gavage with or without 17-β estradiol (E2, 500 μg/kg/d) from PND18-20 (n=8/treatment/block). At 24 hr after the third dose (PND 21), ...

  18. An Investigation About the Effects of Insemination Depth, Cervico-Vaginal Mucus Production and Reflux of Semen in the Vagina After Insemination in Sheep

    Koşum, Nedim

    2000-01-01

    The possible influence of factors such as depth of insemination, cervico-vaginal mucus production and reflux of semen in the vagina after insemination in German merinolandrace were considered. Fresh diluted semen was inseminated intracervically. The results obtained for non-return-rate, lambing rate and fecundity are 49.01%, 39.75% and 64.55% respectively. The year had a significant effect (p ² 0.05) on non-return-rate and lambing rate but not on fecundity.The other parameters considered d...

  19. 婴幼儿阴道内胚窦瘤的CT和MRI诊断%CT and MRI diagnosis of endodermal sinus tumor of vagina in infants

    胡悦林; 刘鸿圣; 罗源利; 周宁; 田金生; 鹿连伟

    2013-01-01

      目的探讨婴幼儿阴道内胚窦瘤的CT和MRI表现特点。方法回顾性分析8例经病理证实的婴幼儿阴道内胚窦瘤的CT及MRI表现,分析总结其影像学特点。结果阴道内胚窦瘤瘤体较大,多呈类圆形,CT平扫密度欠均匀,均可见坏死囊变区域。MRI检查瘤体在T1WI序列上呈等低混杂信号,在T2WI序列上以稍高信号为主,信号混杂不均。CT及MRI增强扫描均呈明显不均匀强化,以病灶周边强化最为显著。结论阴道内胚窦瘤的CT和MRl表现具有一定特征性,结合血清AFP显著升高,可以明确诊断。MRI在显示病灶向周围浸润程度、判断疗效及肿瘤复发方面优于CT。%  Objective To assess the CT and MRI features of endodermal sinus tumors of vagina in infants.Methods The CT and MRI of pathologically confirmed endodermal sinus tumors of vagina in eight infants were analyzed retrospectively.Results Endodermal sinus tumor of vagina showed a large soft tissue mass similar-circular,and the density was inhomogeneous All cases are Endodermal sinus tumor of vagina appeared as a large round soft tissue mass with heterogeneous density,variable necrosis and cystic degeneration on unenhanced CT. The tumor had heterogeneous low to intermediate T1 and slightly high T2 signal intensities. Heterogeneous enhancement especially peripherally was noted on both CT and MRI.Conclusions The CT and MRI features of heterogeneously enhancing vaginal mass with necrosis and cystic degeneration in the setting of elevatedα-fetoprotein level suggest diagnosis of endodermal sinus tumor. MRI is superior to CT in showing surrounding tumor infiltration and tumor recurrence.

  20. La vagina dentada: una interpretación de la Estela 25 de Izapa y las guacamayas del juego de pelota de Copán The dented vagina: an interpretation for Stela 25 of Izapa and ballcourt macaws of Copan

    Oswaldo Chinchilla Mazariegos

    2010-01-01

    Full Text Available Las aves representadas en la Estela 25 de Izapa y el juego de pelota de Copán forman el punto de partida para un examen del tema mitológico de la vagina dentada en Mesoamérica, y sus expresiones en el arte y la narrativa. Un amplio conjunto de narraciones mitológicas recopiladas en México y Guatemala sirve como base para un examen de la historia de Siete Guacamayo en el Popol Vuh, la cual se interpreta como una variante de un mito ampliamente difundido, relacionado con el origen del Sol y la Luna. La identificación de asuntos comunes, entre ellos el de la vagina dentada, refuerza la relación entre el mito del Popol Vuh y las representaciones de Izapa y Copán. A la vez, revela detalles poco conocidos sobre el simbolismo sexual presente en los mitos cosmogónicos mesoamericanos.The birds represented at Stela 25 of Izapa and Copan ball court are the starting point for the analysis of the mythological topic focused on the vagina dentata in Ancient Mesoamerica, as well as their expressions on art and narrative. A large body of mythological narratives is used as a basis for the examination of the "Siete Guacamayo" story included in the Popol Vuh, which is interpreted as part of a widely extended myth related with the creation of the Sun and the Moon. The identification of common issues, as the vagina dentata topic, strengthens the links between the Popol Vuh myth and the Izapa and Copan representations. It also reveals less known details on the sexual symbolism included in the Mesoamerican cosmogonic myths.

  1. Normal tissue tolerance to external beam radiation therapy: The vagina; Dose de tolerance a l'irradiation des tissus sains: le vagin Normal

    Magne, N. [Unite de curietherapie, departement de radiotherapie, institut de cancerologie de la Loire, 42 - Saint-Priest-en-Jarez (France); Chargari, C. [Service d' oncologie radiotherapie, hopital d' instruction des armees du Val-de-Grace, 75 - Paris (France); Pointreau, Y. [Clinique d' oncologie radiotherapie, centre Henry-S.-Kaplan, hopital de Bretonneau, CHU de Tours, 37 - Tours (France); Haie-Meder, C. [Service de curietherapie, departement de radiotherapie, institut Gustave-Roussy, 94 - Villejuif (France)

    2010-07-15

    The vagina is a virtual cavity involved in sexual reproduction field. Due to its anatomical location, it may be exposed in whole or in part to ionizing radiation in external radiotherapy and/or brachytherapy of the pelvic region. This review aims to describe the vaginal acute and late side effects due to radiation, probably inadequately reported in the literature. Medline and PubMed literature searches were performed using the keywords -vaginal - radiotherapy - toxicity. The acute and late functional changes after external beam radiation consist mainly of drought. Their incidences are poorly described in the literature and the delivered doses even less. Recommendations are non-existent as the normal tissue complication probability (NTCP). Brachytherapy delivers high and heterogeneous doses, making it difficult to estimate the dose. The concomitant administration of chemotherapy appears to be a factor increasing the risk of toxicity. Modern techniques of conformal radiotherapy with modulated intensity appear to have little impact on this body. Only a maximum dose on each third of the vagina appears to be currently proposed to avoid the risk of side effects. (authors)

  2. Conceptual knowledge of vesico-vagina fistula among parents, teachers and counsellors of senior secondary students in Warri South local government area of Delta State, Nigeria

    Imoukhede M.O

    2015-04-01

    Full Text Available Background: VVF is leakages of urine and faeces through the vagina. It is rampant in the North and the Eastern parts of Nigeria due to the forced marriage of girls at about the age of eleven. This may be attributed to their small pelvises which have resulted in harmful reproductive health practice. The disability and suffering from obstetric fistula remains a neglected issue in global health. Aim: This study seeks to explore the conceptual knowledge of vesico-vagina fistula (VVF among parents, teachers and counselors of senior secondary school students in Warri South local government area of Delta state. Methods: A survey design was used. Random sampling method was used to select a total number of six hundred respondents including parents, teachers and counselors that participated in the study, but only five hundred and eleven questionnaires were retrieved. The questionnaire was divided into two sections containing information on demography and selected variables for the study. Data was analyzed using descriptive statistics of Anova and t-tests. Result: the study revealed that there is no significant difference in the conceptual knowledge of VVF among parents, teachers and counselors of senior secondary school students either by educational status or location. Conclusion: It can be concluded that parents, teachers and counselors of senior secondary school have very little knowledge about VVF. There is need for educational programmes on VVF to enlighten them about VVF and the danger it poses.

  3. The Clinical Application of Micro-ecosystem in Vagina and Mixed Infection%阴道微生态评价系统的临床应用与混合感染

    王梅(综述); 岳惠芬(审校)

    2015-01-01

    The microbe community of the vagina has formed a coordinated equivalent balance with the host cell and the environment.This kind of micro-ecosystem balance of the vagina is necessary for maintai-ning the well-being of the organism.Many reproductive tract infection diseases were usually found in clinical entity because of the imbalance of the micro-ecology of the vagina.The evaluating system of the micro-eco-system of the vagina could quickly diagnose the common clinical vaginitis .To fully evaluate the vaginosis and the situation of the micro-ecosystem of the vagina before and after the treatment plays an important role in treating the complicated infection of the vagina and decreasing the recurrence .%阴道内的微生物群落与宿主、环境构成了动态协调的平衡关系,这种阴道的微生态平衡对维持机体的健康是必要的。许多临床上常见的生殖道感染性疾病均存在的明显的阴道微生态系统失衡,阴道微生态评价体系可以快速诊断临床常见的阴道炎症,全面评价阴道感染及治疗前后的阴道微生态状况,对阴道混合感染的治疗及降低复发率等起着重要的作用。

  4. Total cystectomy and subsequent urinary diversion to the prepuce or vagina in dogs with transitional cell carcinoma of the trigone area: a report of 10 cases (2005-2011).

    Saeki, Kohei; Fujita, Atsushi; Fujita, Naoki; Nakagawa, Takayuki; Nishimura, Ryohei

    2015-01-01

    The cases of 10 dogs with transitional cell carcinoma of the urinary bladder that underwent total cystectomy were retrospectively reviewed to evaluate the feasibility and outcome of total cystectomy and ureteral transplantation to the prepuce or vagina. Dehiscence of ureterostomy (n = 2), pyelonephritis (n = 3), oliguria (n = 2), azotemia (n = 1), and ureteral obstruction (n = 1) were observed complications. The estimated median survival time was 385 days. This study demonstrates the feasibility of total cystectomy and subsequent urinary diversion to the prepuce or vagina in dogs. Compared to previous ureterocolonic anastomosis, this technique is associated with fewer gastrointestinal and neurologic complications. PMID:25565719

  5. The use of peritoneum for laparoscopic vaginoplasty in patients with congenital absence of vagina%腹腔镜下腹膜代阴道治疗先天性无阴道

    王明波; 刘穗; 刘喻; 余幼辉

    2010-01-01

    目的 探讨腹腔镜下腹膜代阴道成形术的效果.方法 2003年10月至2009年1月共行腹腔镜下腹膜代阴道成形术9例,通过腹腔镜探查盆腔,游离盆腔腹膜,分离人工阴道腔穴,将游离盆腔腹膜自人工腔穴牵出,缝合形成人工阴道.结果 手术时问120~170 min,术中出血50~200 ml,术后第2天肛门排气,人工阴道深度10~12 cm.随访时间3年,人工阴道黏膜红润、光滑、弹性好,功能和形态达到生理要求,已婚者述性生活满意.结论 腹腔镜下腹膜代阴道成形术创伤小,术后恢复快,不破坏机体完整性,腹膜形成的阴道壁光滑,与正常阴道黏膜相似,符合生理状态,是治疗先天性无阴道较理想的手术方式.%Objective To study the effect of the use of peritoneum tor laparoscopic vaginoplasty in patients with congenital absence of vagina.Methods 9 patients with congenital absence of vagina were perfomed peritoneum for laparoscopic vaginoplasty from Oct ,2003 to Jan ,2009.Explore the pelvic by laparoscopic vaginoplasty,free the pelvic peritoneum,detach artificial vagina,pull the pelvic peritoneum from the artificial vagina,suture to form a vagina.Results The operation time was 120 ~ 170 minutes.Blood loss of operation was 50 ~200 ml.All patients had gas discharged 2 days after operation.Depth pf vagina made were 10 ~ 20 cm.3 years after operation,the vagina made all have a smoothy and tendy mucous membrane that their function or shape reached physiological goal Patients or their spouses were satisfied to their sex activity.Conclusion Use of peritoneum for laparoscopic vaginoplasty in patients with congenital absence of vagina has the advantages of short operation time,rapid recovery and no impact of physiological organ.Vagina membrane made by peritonem were smoothy and alike to normal vagina membrane.The use of peritoneum for laparoscopic vaginoplasty is an good operation way in patients with congenital absence of vagina.

  6. Effect of Bacterial Vaginitis on the Immune Environment of Vagina%细菌性阴道炎对阴道免疫环境的影响

    姚锋

    2015-01-01

    目的:探讨细菌性阴道炎对阴道内免疫环境的影响。方法2015年1—7月整群收集该院诊治的80例细菌性阴道炎患者和80例正常妇女阴道灌洗液和白带,ELISA检测阴道灌洗液中IL-1β,IL-6, IL-8及HBD-2。白带涂片革兰氏染色镜检阴道杆菌和其他杂菌的数目。结果细菌性阴道炎组较正常妇女组阴道内IL-1β水平升高(P<0.001), HBD-2水平降低(P<0.001),IL-6,IL-8差异无统计学意义(P=0.631,P=0.764)。细菌性阴道炎组较正常妇女组阴道内杂菌数量增多(P<0.001),阴道杆菌数量减少(P<0.001)。结论阴道杆菌对阴道内环境有免疫调节作用,细菌性阴道炎杂菌生长会破坏阴道内免疫环境。%Objective To study the effect of bacterial vaginitis on the immune environment of vagina. Methods From Jan-uary 2015 to July 2015 ,vaginal lavage fluid and leucorrhea of 80 cases of bacterial vaginitis patients and 80 cases of nor-mal women were collected , IL-1β,IL-6, IL-8 and HBD-2 in vaginal lavage fluid were detected by ELISA, the number of vagina bacillus and other miscellaneous bacteria was examined by leucorrhea smear gram staining microscopic. Results Compared with the normal women group, IL-1βlevel of vaginal internal in the bacterial vaginitis group increased (P<0.001) and HBD-2 decreased (P<0.001),the difference of IL-6 and IL-8 was not statistically significant (P=0.631,P=0.764). Compared with the normal women group, the number of miscellaneous bacteria in the bacterial vaginitis group increased (P<0.001)but the number of vagina bacillus decreased (P<0.001). Conclusion Vagina bacillus has an immune and adjustment effect on vaginal internal environment and the growth of bacterial vaginitis bacteria can destroy vaginal internal immune environment.

  7. [Cytological and bacteriological examinations of the cervix and vagina. A review of the results obtained in a laboratory for analyses in Guadeloupe (author's transl)].

    Millan, J; Crenn, O; Lidome, E

    1981-01-01

    The authors give the results of their cytological and bacteriological examinations of the cervix and vagina carried out routinely in a laboratory. They emphasize, in detailing their method of working, the criteria that they feel must be adopted in an attempt to code the qualitative appraisal of direct examination and the result of studying the cultures. The first part of the paper deals with an overall survey of the 4,573 examinations which were carried out over a period of 8 years. The second part is concerned with a more detailed analysis of the 883 samples which were divided into 4 categories: pregnant women, those having oral contraception, those with an intra-uterine device, and others. There are several variations revealed between these 4 categories as far as the white cell count, the bacterial flora and even pathogenic organisms are concerned. PMID:7334191

  8. The effect of copaiba balsam on Walker 256 carcinoma inoculated into the vagina and uterine cervix of female rats Efeito do óleo de copaíba no tumor de Walker 256 inoculado em vagina e colo de útero de ratas fêmeas

    Nara Macedo Botelho Brito; Marcus Vinicius Henriques Brito; Rita de Kássia Vidigal Carvalho; Lia Tavares de Moura Brasil Matos; Rodolfo Costa Lobato; Suelen Costa Correa; Rosângela Baía Brito

    2010-01-01

    PURPOSE: To verify the copaiba balsam (Copaifera officinalis) effect on Walker 256 carcinoma inoculated into vagina and uterine cervix of rats. METHODS: Eighteen female Wistar rats weighing between 180-250g were used, distributed into 2 groups (GCop, GC). On the 1st day of the experiment, 0.3 ml of Walker 256 carcinoma (2x10(6) concentration) was inoculated in both groups; on the 3rd day of the experiment, it was given 4.8 ml/kg of distilled water to the GC group, and 4.8 ml/kg of copaiba bal...

  9. Curative observation of disposable bacteriostatic absorber for vagina in the treatment of gestational candida vulva va-gina disease%唯阴康治疗妊娠期念珠菌性外阴阴道病效果观察

    杨春; 宋晓蓉

    2014-01-01

    目的:观察唯阴康治疗妊娠期念珠菌性外阴阴道病的临床疗效及安全性。方法选取门诊2012年5月-2013年11月诊治妊娠期念珠菌性外阴阴道病患者95例,随机分为观察组(唯阴康治疗)50例和对照组(碳酸氢钠冲洗)45例,治疗10d 后比较治疗效果并观察不良反应。结果观察组总有效率为86.0%高于对照组的62.2%,差异有统计学意义(P <0.05)。2组患者治疗期间均未出现明显不良反应。结论唯阴康治疗妊娠期念珠菌性外阴阴道病方便、安全、有效,值得临床推广。%Objective To explore the clinical effect and safety of disposable bacteriostatic absorber for vagina(Weiy-inkang)in the treatment of gestational candida vulva vagina disease. Methods During May 2012 to November 2013,125 ca-ses of patients with gestational candida vulva vagina disease cured by outpatient was selected as the research objects,which were randomly divide into observation group(Weiyinkang treatment)including 50 cases,and control group(sodium bicarbon-ate flush)including 45 cases according to the random number table,and the treatment effect and adverse reaction of which were compared after ten days' cure. Results The total effective rate of observation group was 86. 0% ,which was higher than 62. 2% of the control group,and the difference was statistical significance(P < 0. 05). Neither of 2 groups had obvious ad-verse reaction. Conclusion The treatment of Weiyinkang on gestational candida vulva vagina disease is convenient,safe and effective,which is worthy of clinical promotion.

  10. Three-dimensional(3D) Pelvic Floor Ultrasound:Transversal Imaging of Nulliparous Vagina at Different Level%未产妇阴道不同水平横断面的三维盆底超声观察

    李勤; 胡兵; 应涛

    2009-01-01

    Objective To search for an effective imaging method for the morphological observation of female pelvic support by studying 3D ultrasound image features of nulliparous vagina and perivaginal structures at different level.Methods Fifty nulliparas were examined by 3D pelvic floor ultrasonography.The appearance of vagina and perivaginal structures was observed from vaginal vault to orifice in transversal 3D reconstruction image of pelvic floor.Results Three-dimensional pelvic floor ultrasound showed cross-sectional imaging of the whole vagina clearly.The vaginal transversal morphologies were different at different level.It was lip-like in proximal vagina,butterfly-like in middle vagina and crescent-like in distal vagina.The perivaginal structures at different level were different.Perineal body was at distal vagina level,urethrovaginal septum,rectovaginal septum and paravaginal support at middle vagina level,perivaginal connective tissue at proximal vagina level.All were uniform,dense and complete.Conclusions The 3D pelvic floor ultrasound images of vagina and perivaginal structures at different level are distinct,which is valuable for the study of 3D ultrasound in female pelvic support and pelvic floor dysfunction.%目的 探讨未产妇不同水平阴道横断面及周围结构的三维盆底超声表现,为女性盆底支持结构的形态学观察提供有效的影像学方法 .方法 对50例无生育史年轻女性进行三维盆底超声检查,获得盆底横断面声像图,连续观察宫颈外口至阴道外口间阴道横断面及周围结构的声像图表现.结果 三维盆底超声清晰显示阴道全程的横断面声像图.不同水平的阴道横断面形态不同:近段阴道呈"唇形",中段阴道呈"蝶形",远段阴道呈"月牙形".不同水平的阴道周围结构不同:远段阴道水平可见会阴体,中段阴道水平可见尿道阴道隔、直肠阴道隔及阴道旁支持结构,近段阴道水平可见阴道周围结缔组织,阴道周围

  11. Analysis of microbial flora in dairy cow's vagina, and the isolation and identification of lactobacillus%奶牛阴道菌群分析与乳酸菌的分离及鉴定

    侯荣伦; 程超; 付艳茹; 刘彦民; 李利平; 郝永清; 黄少磊

    2011-01-01

    目的 研究奶牛阴道菌群,并从健康奶牛阴道分离出产酸能力很强的乳酸菌.方法 采用常规的方法对奶牛阴道进行细菌的分离及鉴定,并进行菌群分析.结果 健康奶牛阴道优势菌群主要为乳酸菌(P<0.01),屡配不孕奶牛阴道优势菌群主要为金黄色葡萄球菌(P<0.01);从健康奶牛阴道分离出的乳酸菌为55株,其中产酸能力很强的6株乳酸菌鉴定结果分别为Lactobacillus plantarum,Lactobacilluz brevis,Enterococcus faecalis,Lactococcus garvieae、Lactobacillus kitasatonis和Lactobacillus amylovorus.结论 奶牛阴道菌群中分离的6株乳酸菌可作为潜在的奶牛阴道微生态制剂进行深入研究.%Objective To Analyse the microbial flora in dairy cow's vagina, isolate and identify Lactobacillus with strong acid-producing capacity from vagina of healthy dairy cows. Method The standard microbiological methods were used to isolate and identify the bacteria in dairy cow's vagina. Result The most dominant bacteria in the vagina of healthy dairy cows belonged to Lactobacillus( P <0.01 ); The most dominant bacteria in the vagina of infertile dairy cows belonged to Staphylococcus aureus(P < 0.01 ); 55 lactic acid bacteria were isolated from the vagina of healthy dairy cows. 6 of which with strong acid-producing capacity were further identified as Lactobacillus plantarum, Lactobacillus brevis, Enterococcus faecalis, Lactococcus garvieae, Lactobacillus kitasatonis and Lactobacillus amylovorus, respectively. Conclusion The 6 lactic acid bacteria strains can be used as the candidates for the preparation of microecological additives of dairy cows and need further study.

  12. An evaluation of the amount of nonoxynol-9 remaining in the vagina up to 4 h after insertion of a vaginal contraceptive film (VCF) containing 70 mg nonoxynol-9.

    Mauck, C K; Allen, S; Baker, J M; Barr, S P; Abercrombie, T; Archer, D F

    1997-08-01

    The objectives of this study were to determine the amount of nonoxynol-9 (N-9) remaining in the vagina 30 min and 1, 1.5, 2, and 4 h after vaginal insertion of a single sheet of VCF containing 70 mg N-9 and to compare these results to the manufacturer's instructions for use of this product. A new method of vaginal lavage was used to obtain samples for N-9 determination. This was an open-label, noncomparative, pharmacokinetic study in 12 healthy women volunteers not at risk for pregnancy. The study consisted of a screening visit followed by five test visits approximately 1 month apart and a final visit 1 week after all test visits were completed. At each test visit, the investigator inserted a single sheet of VCF in the vagina of the volunteer at midcycle. The volunteer remained in the clinic and underwent vaginal lavage with normal saline after one of five specified time intervals had elapsed. The sequence of the intervals completed by each volunteer was determined by randomization. When undissolved film was found in the vagina, it was removed prior to lavage and assayed for N-9 content separately from that recovered in lavage fluid. It was assumed that the N-9 in undissolved film would not contribute significantly to sperm immobilization. Between 18.5 and 28.5 mg of N-9 were recovered in lavage fluid after intervals of 0.5, 1, 1.5, and 2 h. These levels did not differ statistically (p > 0.05). The amount of N-9 recovered dropped significantly at 4 h to 11.0 mg. If it is assumed that an N-9 concentration of 0.100 mg/mL is required to immobilize sperm in vitro, this study suggests that the amount of N-9 remaining in the vagina in the form of dissolved film up to 4 h after insertion of VCF is sufficient to immobilize sperm. The lavage procedure may not have recovered all N-9 remaining in the vagina. However, intercourse did not take place between insertion and lavage; if it had, the proportion of the film remaining undissolved and the total amount N-9 remaining in

  13. Effects of depomedroxyprogesterone acetate on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats (Rattus norvegicus

    Agenor Storti-Filho

    2011-03-01

    Full Text Available The objective of this study was to determine the effect of medroxyprogesterone acetate (DMPA on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats. The animals were divided into negative control groups (NCG, which received injections of sterile saline; positive control groups (PCG, which were given injections of estradiol valerate; and progesterone groups (PG, which were given injections of Depo-Provera®. After one week of hormonal induction, vaginal infection by C. albicans was induced in all the groups and detected by vaginal yeast culture and Papanicolaou smear. In addition, scanning and transmission electron microscopy images were obtained to confirm the vaginal infection by yeast in PG. A difference in progesterone levels in PG was observed between the basal level and after hormonal induction (PO objetivo do presente estudo foi determinar os efeitos do acetato de depomedroxyprogesterona (ADMP no desenvolvimento e manutenção de Candida albicans na vagina de ratas Wistar ooferectomizadas. Os animais foram divididos em grupos controle negativos (GCN, que receberam injeções de salina estéril; grupos controle positivos (GCP, que receberam injeções de valerato de estradiol; e grupos progesterona (GP, nos quais foram feitas injeções de Depo-Provera®. Após uma semana da aplicação hormonal, foi induzida a infecção vaginal por C. albicans em todos os grupos, detectada por cultura para leveduras vaginais e esfregaço de Papanicolaou. Foram feitas ainda imagens por microscopia eletrônica de varredura e transmissão para confirmar a infecção pela levedura no GP. Foram observados diferentes níveis de progesterona em GP, entre os valores basais e após a indução hormonal (P<0,0001. Neste grupo, 100,0% das ratas contraíram a infecção vaginal na primeira semana, mas não a mantiveram até a terceira semana. A forma farmacêutica de ADMP foi efetiva em induzir as fases de metaestro e

  14. 瘢痕子宫瘢痕妊娠阴道彩超的检查%Scar Uterine Scar Pregnancy Vagina Colour to Exceed Examination

    袁雪英

    2013-01-01

    Objective:To explore the vagina colour to exceed to check for improving the significance of treatment of scar uterine scar pregnancy. Method:82 cases of cesarean section with postpartum scar pregnancy were retrospectively analyzed in our hospital from March 2010 to May 2013,and were randomly divided into two groups:observation group for vagina colour to exceed examination of patients,42 cases;the control group for patients with abdominal colour to exceed,40 cases. Compared the diagnostic coincidence rate of two groups. Result:Observation group diagnostic coincidence rate was 95.24%(40/42),the control group was 67.50%(27/40),the two groups had statistical significance(P<0.05);the missed diagnosis rate was 2.38%(1/42) in observation group,the control group was 12.50%(5/40).Conclusion:Transvaginal doppler colour to exceed examination can accurately positioning scar pregnancy surgical site,and damage to patients is small,less complications,is of great significance in clinic,is worth promoting.%目的:探讨阴道彩超检查对于提高治疗瘢痕子宫瘢痕妊娠的重要意义。方法:回顾性分析2010年3月-2013年5月本院收治的82例剖宫产产后瘢痕妊娠患者临床资料,随机分为两组,观察组42例进行阴道彩超检查,对照组40例进行腹部彩超检查。比较两组诊断符合率。结果:观察组诊断符合率95.24%(40/42),高于对照组的67.50%(27/40),两组比较差异具有统计学意义(P<0.05);观察组漏诊率2.38%(1/42)低于对照组的12.50%(5/40)。结论:经阴道多普勒彩超的检查能够准确的定位瘢痕妊娠的手术部位,在临床上具有重要意义,值得推广。

  15. Atopobium vaginae与细菌性阴道病关系的研究%Study on the association of Atopobium vaginae with bacterial vaginosis

    张彦; 宋磊

    2007-01-01

    目的:应用非培养方法研究Atopobium vaginae与细菌性阴道病的关系.方法:根据Nugent评分标准从15例健康妇女及17例BV患者的其阴道分泌物中提取细菌总DNA.分别选择健康妇女及BV患者样本各3例,构建16S rRNA基因克隆文库并进行测序分析.应用Atopobium vaginae16S rRNA基因的特异性引物对32例样本进行PCR扩增.结果:Atopobium vaginae是BV患者阴道菌群中的优势菌种,它存在于大部分(14/17)BV患者阴道中,健康妇女阴道中(1/15)则很罕见.结论:Atopobium vaginae与细菌性阴道病的发生有一定的相关性.

  16. Inhibition of HIV-1 infection in ex vivo cervical tissue model of human vagina by palmitic acid; implications for a microbicide development.

    Xudong Lin

    Full Text Available BACKGROUND: Approximately 80% of all new HIV-1 infections are acquired through sexual contact. Currently, there is no clinically approved microbicide, indicating a clear and urgent therapeutic need. We recently reported that palmitic acid (PA is a novel and specific inhibitor of HIV-1 fusion and entry. Mechanistically, PA inhibits HIV-1 infection by binding to a novel pocket on the CD4 receptor and blocks efficient gp120-to-CD4 attachment. Here, we wanted to assess the ability of PA to inhibit HIV-1 infection in cervical tissue ex vivo model of human vagina, and determine its effect on Lactobacillus (L species of probiotic vaginal flora. PRINCIPAL FINDINGS: Our results show that treatment with 100-200 µM PA inhibited HIV-1 infection in cervical tissue by up to 50%, and this treatment was not toxic to the tissue or to L. crispatus and jensenii species of vaginal flora. In vitro, in a cell free system that is independent of in vivo cell associated CD4 receptor; we determined inhibition constant (Ki to be ∼2.53 µM. SIGNIFICANCE: These results demonstrate utility of PA as a model molecule for further preclinical development of a safe and potent HIV-1 entry microbicide inhibitor.

  17. Citologia Hormonal do Trato Urinário Baixo e da Vagina de Mulheres na Pós-menopausa, antes e durante Estrogenioterapia Oral e Transdérmica

    Lustosa Áurea Belas; Girão Manoel João Batista Castello; Sartori Marair Gracio Ferreira; Baracat Edmund Chada; Lima Geraldo Rodrigues de

    2002-01-01

    Objetivo: avaliar a ação dos estrogênios por via oral ou transdérmica nas células do trato urinário baixo e da vagina, em mulheres menopausadas. Métodos: foram incluídas 25 mulheres na pós-menopausa, nas quais se estudaram os efeitos citológicos da terapia de reposição hormonal estrogênica, por via oral e por via transdérmica, sobre as células da vagina e do sedimento urinário. As pacientes foram distribuídas aleatoriamente em 2 grupos: Grupo I, constituído por 14 mulheres que receberam 0,625...

  18. Avaliação dosimétrica de uma combinação de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porção distal da vagina Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina

    Roger Guilherme Rodrigues Guimarães

    2009-08-01

    Full Text Available OBJETIVO: Avaliar uma alternativa de braquiterapia para tumores do colo uterino acometendo a porção distal da vagina, sem aumentar os riscos de toxicidade. MATERIAIS E MÉTODOS: Estudo teórico comparando três diferentes aplicadores de braquiterapia intracavitária de alta taxa de dose: sonda intrauterina e cilindro vaginal (SC; sonda e anel associado ao cilindro vaginal (SA+C e um aplicador virtual com sonda, anel e cilindro vaginal em um único conjunto (SAC. Foram prescritas doses de 7 Gy no ponto A e 5 Gy na superfície ou a 5 mm de profundidade na mucosa vaginal, mantendo as doses nos pontos de reto, bexiga e sigmoide abaixo dos limites de tolerância. Foram comparados os volumes englobados pelas isodoses de 50% (V50, 100% (V100, 150% (V150 e 200% (V200, respectivamente. RESULTADOS: Tanto SA+C quanto SAC apresentaram melhor distribuição de dose quando comparados ao aplicador SC. A distribuição de dose obtida com SA+C foi semelhante à do aplicador SAC, sendo V150 e V200 cerca de 50% maiores para SA+C, todavia, dentro do cilindro. CONCLUSÃO: A utilização de SA+C em uma única aplicação em dois tempos pode ser uma alternativa de tratamento para pacientes que apresentam tumores de colo uterino com acometimento distal da vagina.OBJECTIVE: To evaluate an alternative brachytherapy technique for uterine cervix cancer involving the distal vagina, without increasing the risk of toxicity. MATERIALS AND METHODS: Theoretical study comparing three different high-dose rate intracavitary brachytherapy applicators: intrauterine tandem and vaginal cylinder (TC; tandem/ring applicator combined with vaginal cylinder (TR+C; and a virtual applicator combining both the tandem/ring and vaginal cylinder in a single device (TRC. Prescribed doses were 7 Gy at point A, and 5 Gy on the surface or at a 5 mm depth of the vaginal mucosa. Doses delivered to the rectum, bladder and sigmoid colon were kept below the tolerance limits. Volumes covered by the

  19. Total cystectomy and subsequent urinary diversion to the prepuce or vagina in dogs with transitional cell carcinoma of the trigone area: A report of 10 cases (2005–2011)

    Saeki, Kohei; Fujita, Atsushi; Fujita, Naoki; Nakagawa, Takayuki; NISHIMURA, Ryohei

    2015-01-01

    The cases of 10 dogs with transitional cell carcinoma of the urinary bladder that underwent total cystectomy were retrospectively reviewed to evaluate the feasibility and outcome of total cystectomy and ureteral transplantation to the prepuce or vagina. Dehiscence of ureterostomy (n = 2), pyelonephritis (n = 3), oliguria (n = 2), azotemia (n = 1), and ureteral obstruction (n = 1) were observed complications. The estimated median survival time was 385 days. This study demonstrates the feasibil...

  20. 唯阴康预防宫颈癌放射治疗阴道并发症的观察%Wei yin kang to prevent cervical cancer radiotherapy vagina observation of complications

    杨爱青

    2015-01-01

    目的:对宫颈癌放射治疗的患者应用唯阴康预防放射性阴道并发症的效果观察。方法选择2008年3月至2012年12月宫颈癌患者160例,随机分为2组,80例为观察组,80例为对照组,对照组每日常规给予阴道冲洗,观察组,每日常规给予阴道冲洗后隔日给予阴道填塞唯阴康1支,共2个月,第3个月每周用2支。结果观察组使用唯阴康后阴道并发症明显低于对照组。%Objective:To apply only in patients with cervical cancer radiotherapy of Yin, prevention of complications of the vagina effect observation. Methods:March 2008-December 2012 160 cases of cervical cancer patients, randomly divided into 2 groups, 80 cases in observation group, 80 cases as control group, control group a daily routine for vagina washing, observation group, a day after the daily routine for vagina washing give vaginal tamponade wei Yin kang 1, 2 months, 3 months, two a week. Results:the observation group USES the vagina after wei Yin kang complications were significantly lower than the control group.

  1. Detection of the Human 70-kD and 60-kD Heat Shock Proteins in the Vagina: Relation to Microbial Flora, Vaginal pH, and Method of Contraception

    P. Giraldo

    1999-01-01

    Full Text Available The expression of the 60-kD and 70-kD heat shock proteins (hsp60 and hsp70 in the vaginas of 43 asymptomatic women of reproductive age with or without a history of recurrent vulvovaginitis (RVV were compared. Vaginal wash samples were obtained and assayed by enzyme-linked immunosorbent assay (ELISA for human hsp60 and hsp70. Heat shock protein 70 was not detected in any of the 19 women with no history of RVV, and hsp60 was present in only one woman in this group. In contrast, in the RVV group, 11 (45.8% were hsp60-positive and eight (33.3% were hsp70-positive. The presence of either heat shock protein in the vagina was associated with an elevated vaginal pH (>4.5. Bacterial vaginosis or Candida was identified in some of the asymptomatic subjects; their occurrence was significantly higher in women with vaginal hsp70 than in women with no heat shock proteins. Oral contraceptives were used by 35.7% of subjects who were negative for vaginal heat shock proteins, as opposed to only 12.5% of women who were positive for hsp70 and 8.3% who were positive for hsp60. Expression of heat shock proteins in the vagina may indicate an altered vaginal environment and a susceptibility to vulvovaginal symptoms. Infect. Dis. Obstet. Gynecol. 7:23–25, 1999.

  2. Detection of the human 70-kD and 60-kD heat shock proteins in the vagina: relation to microbial flora, vaginal pH, and method of contraception.

    Giraldo, P; Neuer, A; Ribeiro-Filho, A; Linhares, I; Witkin, S S

    1999-01-01

    The expression of the 60-kD and 70-kD heat shock proteins (hsp60 and hsp70) in the vaginas of 43 asymptomatic women of reproductive age with or without a history of recurrent vulvovaginitis (RVV) were compared. Vaginal wash samples were obtained and assayed by enzyme-linked immunosorbent assay (ELISA) for human hsp60 and hsp70. Heat shock protein 70 was not detected in any of the 19 women with no history of RVV, and hsp60 was present in only one woman in this group. In contrast, in the RVV group, 11 (45.8%) were hsp60-positive and eight (33.3%) were hsp70-positive. The presence of either heat shock protein in the vagina was associated with an elevated vaginal pH (>4.5). Bacterial vaginosis or Candida was identified in some of the asymptomatic subjects; their occurrence was significantly higher in women with vaginal hsp70 than in women with no heat shock proteins. Oral contraceptives were used by 35.7% of subjects who were negative for vaginal heat shock proteins, as opposed to only 12.5% of women who were positive for hsp70 and 8.3% who were positive for hsp60. Expression of heat shock proteins in the vagina may indicate an altered vaginal environment and a susceptibility to vulvovaginal symptoms. PMID:10231004

  3. The clinical study of the extensive hysterectomy vagina yarn after anesthesia%广泛全子宫切除术前实施麻醉后行阴道塞纱的临床研究

    黄兰英; 陈少君; 刘萍凤; 康淑泉

    2014-01-01

    目的:探讨广泛全子宫切除术前实施麻醉后行阴道塞纱的效果。方法选择行广泛全子宫切除术患者60例,设对照组和实验组各30例,对照组实施有针对性阴道塞纱,实验组实施麻醉后行阴道塞纱。术后由手术医生对2患者术前阴道塞纱的效果进行评估,并在术后1天采用自行设计的患者满意度调查表对两组病人进行调查。结果实施麻醉后行阴道塞纱效果优于对照组(χ2=6.66,P !0.01),实验组患者与对照组患者满意度调查相比差异有统计学意义(χ2=38.46,P !0.01)。结论广泛全子宫切除术前实施麻醉后行阴道塞纱更能体现人性化服务,可提高手术效果,减少手术并发症,提高医疗护理质量。%Objective To investigate the effect of the extensive hysterectomy vagina yarn after anesthesia.Method 60 patients with extensive hysterectomy were selected which were divided into control group and experimental group.Control group implement the targeted vagina gauze, while the experimental group implement vagina yarn after anesthesia.The doctors evaluated the effect of the patient’s vagina yarn on two the groups after the intervention.The patient satisfaction questionnaire was used on two the groups of patients in the investigation.ResultsThe results of the experimental group is better than the control group(χ2 =6.66,P<0.01 ).The difference between the experimental group patients and the control group patients’satisfaction was statistically significant.Conclusion Extensive hysterectomy vagina yarn after anesthesia is more human-ized service and it is beneficial to improve the effect of surgery and reduce complications and improve the quality of medical care.

  4. Cervix high-risk HPV infection and vagina environment correlation factor analysis%宫颈高危HPV感染与阴道内环境相关因素分析

    于妍妍; 金哲; 刘艳霞; 黄文玲; 曹颖

    2011-01-01

    Objective To investigate the relationship between vaginal environment change and the cervix high-risk human papilloma virus ( HR-HPV ) infects. Methods 250 female patients were enrolled and received HPV-DNA examination. The woman's vagina secretion were tested by using the vagina secretion method of pendant drop and the Gram dyeing, the fast BV examination reagent box method, the pH indicator paper determination method separately, the results of the vaginitis, vagina cleanliness, vagina pH value, vagina bacteria colony were tested and recorded. Results HPV-DNA results showed that positive results in 124 cases and negative in 126 cases. The Logistic regression analysis results indicated that the pH value, the bacteria colony change and bacterial vaginosis were the HR-HPV infection hazard factor ( OR value were 2. 883, 1. 547 and 2. 409 respectively, P <0. 05 ). the cleanliness, infusoria vaginitis and rayon saccharomycetes vaginitis were not the HR-HPV infection hazard factor( P >0.05 ). Conclusion The pH value, the bacteria colony change and the bacterial vaginosis are the HR-HPV infection hazard factors, but the cleanliness, the infusoria vaginitis and the rayon saccharomycetes vaginitis are not the HR-HPV infection hazard factors.%目的 探讨阴道内环境的变化与宫颈高危人乳头瘤病毒(HR-HPV)感染之间的关系.方法 入选250例女性,进行HPV DNA检测,取阴道分泌物分别采用阴道分泌物悬滴法、Gram染色法、快速BV检测试剂盒法,测阴阴道炎和检道内环境的指标(阴道清洁度、阴道pH值、阴道菌群组成).结果 250例女性中HR-HPV阳性124例、阴性126例.Logistic回归分析结果表明,pH值、菌群变化及细菌性阴道病是HR-HPV感染的危险因素(OR值分别为2.883、1.547、2.409,P均0.05).结论 pH值、菌群变化及细菌性阴道病是HR-HPV感染的危险因素,而清洁度、滴虫性阴道炎及假丝酵母菌阴道炎不是HR-HPV感染的危险因素.

  5. Detection of hydrogen peroxide-producing Lactobacillus species in the vagina: a comparison of culture and quantitative PCR among HIV-1 seropositive women

    Balkus Jennifer E

    2012-08-01

    Full Text Available Abstract Background The presence of hydrogen peroxide (H2O2 producing Lactobacillus in the vagina may play a role in controlling genital HIV-1 shedding. Sensitive molecular methods improve our ability to characterize the vaginal microbiota; however, they cannot characterize phenotype. We assessed the concordance of H2O2-producing Lactobacillus detected by culture with quantitative PCR (qPCR detection of Lactobacillus species commonly assumed to be H2O2-producers. Methods Samples were collected as part of a prospective cohort study of HIV-1 seropositive US women. Cervicovaginal lavage specimens were tested for L. crispatus and L. jensenii using 16S rRNA gene qPCR assays. Vaginal swabs were cultured for Lactobacillus and tested for H2O2-production. We calculated a kappa statistic to assess concordance between culture and qPCR. Results Culture and qPCR results were available for 376 visits from 57 women. Lactobacilli were detected by culture at 308 (82% visits, of which 233 of 308 (76% produced H2O2. L. crispatus and/or L. jensenii were detected at 215 (57% visits. Concordance between detection of L. crispatus and/or L. jensenii by qPCR and H2O2-producing Lactobacillus by culture was 75% (kappa = 0.45. Conclusions Among HIV-1 seropositive women, there was a moderate level of concordance between H2O2-producing Lactobacillus detected by culture and the presence of L. crispatus and/or L. jensenii by qPCR. However, one-quarter of samples with growth of H2O2-producing lactobacilli did not have L. crispatus or L. jensenii detected by qPCR. This discordance may be due to the presence of other H2O2-producing Lactobacillus species.

  6. The effect of copaiba balsam on Walker 256 carcinoma inoculated into the vagina and uterine cervix of female rats Efeito do óleo de copaíba no tumor de Walker 256 inoculado em vagina e colo de útero de ratas fêmeas

    Nara Macedo Botelho Brito

    2010-04-01

    Full Text Available PURPOSE: To verify the copaiba balsam (Copaifera officinalis effect on Walker 256 carcinoma inoculated into vagina and uterine cervix of rats. METHODS: Eighteen female Wistar rats weighing between 180-250g were used, distributed into 2 groups (GCop, GC. On the 1st day of the experiment, 0.3 ml of Walker 256 carcinoma (2x10(6 concentration was inoculated in both groups; on the 3rd day of the experiment, it was given 4.8 ml/kg of distilled water to the GC group, and 4.8 ml/kg of copaiba balsam to the GCop group. On the 12th day, euthanasia was performed and the tumor was grafted, being weighted and verified its volume. The data were submitted to statistical analysis with ANOVA test. RESULTS: It was observed that copaiba balsam presented a negative inhibitory potential of 70%. CONCLUSION: The copaiba balsam stimulated the tumor growth.OBJETIVO: Verificar o efeito do óleo de copaíba da espécie Copaifera officinalis no carcinoma de Walker 256 inoculado em vagina e colo de útero de ratas. MÉTODOS: Foram utilizadas 18 ratas da linhagem Wistar, pesando entre 180-250g, distribuídas em dois grupos (CCop, GC. No 1º dia de experimento, em ambos os grupos foi inoculado 0,3ml de tumor de Walker 256 na concentração de 2x10(6; no 3º dia após essa inoculação, foi iniciada a administração de água destilada na dose de 4,8 ml/kg ao GC, e copaíba na dose de 4,8 ml/kg ao GCop. No 12º dia foi realizada a eutanásia das ratas e ressecado o tumor, sendo este pesado e averiguado seu volume. Os dados obtidos foram submetidos à análise estatística pelo método ANOVA. RESULTADOS: Observou-se que o óleo de copaíba apresentou um potencial inibitório negativo de 70%. CONCLUSÃO: O óleo de copaíba estimulou o crescimento tumoral.

  7. 乙状结肠代阴道成形术治疗先天性无阴道的疗效分析%Clinical effect of sigmoid colon vaginoplasty in treatment of congenital absence of vagina

    唐素蓉; 藤青芳; 张晓丹

    2014-01-01

    Objective To discuss the clinical effect of sigmoid colon vaginoplasty in the treatment of patients with congenital absence of vagina. Methods 4 patients with the congenital absence of vagina treated in this hospital from February 2011 to August 2013 received the treatment of sigmoid colon vaginoplasty. Their average operation time, intraoperative hematoma volume, postoperative complications and postoperative vaginal structure and function were observed. Results 4 patients with the congenital absence of vagina who received the sigmoid colon vaginoplasty were all successful in the operation, with the average operation time of (140.5±26.5)min and average hematoma volume of (118.4±4.5)mL. The vagina formed by the sigmoid colon surgery was close to the normal one in the shape and patients were satisfied with the sex life without any intraoperative or postoperative complication. Conclusion After receiving the sigmoid colon vaginoplasty, patients with the congenital absence of vagina have their operation-formed vaginas basically similar to normal ones in the structure and function. It is characterized by the safe operation, short operation time, limited hematoma volume and little complications, which is worthy to be popularized in the clinical practice.%目的:研究探讨应用乙状结肠代阴道成形术治疗先天性无阴道患者的临床疗效。方法对我院2011年2月~2013年8月收治的先天性无阴道患者4例进行分析,采用乙状结肠代阴道成形术治疗,观察4例采用乙状结肠代阴道成形术的平均手术时间、手术时出血量、手术后的并发症以及手术后阴道的结构和功能的情况。结果采用乙状结肠代阴道成形术治疗的4例先天性无阴道患者手术均获得成功,而且手术的平均时间为(140.5±26.5)min,平均出血量为(118.4±4.5)mL。用乙状结肠手术成的阴道在形态上与正常女性阴道接近,并且患者性生活感觉满意,没有发生手

  8. Character of Psychology of Patients with Congenital Absence of Vagina during Preoperative Period and Nursing Strategy%先天性无阴道患者围手术期心理特点及护理对策

    王小丽

    2011-01-01

    目的探讨先天性无阴道患者围手术期有效的护理措施,提高护理质量.方法:针对患者不同的心理状态进行分类,给予心理辅导,提供相关信息,做出相应的护理对策.结果:43 例患者均痊愈出院,无护理并发症的发生.结论:有效的围手术期护理是手术成功的重要因素之一,应根据患者的病情及心理特点,采取有针对性的护理措施,减轻和消除患者不良的心理反应,促进健康的恢复.本文通过对先天性无阴道患者围手术期心理特点的观察,提出相应的护理措施,并很好地运用于临床.%Objective: To investigate the nursing strategy for patients with congenital absence of vagina during preoperative period in order to improve quality of nursing. Methods: According to different characteristics of psychology of patients, patients were administered with psychological consulting and related nursing strategy.Results: 43 of patients were fully recovery from congenital absence of vagina without complication. Conclusion: Effective nursing during preoperative period is a critical factor for successful surgery. According to different condition and character of psychology of patients, related nursing intervention was administered to relieve negative psychological condition and promote recovery from illness.Out study presented that that it was effective of using of psychological nursing intervention to patients with congenital absence of vagina in clinical work.

  9. “If your vagina could speak, what would it say?”: Dangerous Femininity, Anxious Masculinity and the Threat of Female Desire in the 1975 Pornographic Movie "The Sex that Speaks"

    Garrigou-Kempton, Emilie

    2010-01-01

    The Sex that Speaks, also known in English as Pussy Talks, relates the story of a woman whose vagina inexplicably starts talking and reveals a voracious sexual appetite. In The Indiscreet Jewels, the “jewels” of several women start talking as one man, curious about female sexuality, interrogates them. In both cases, the talking sex is always female and it consistently delivers a uniform message of women’s sexual promiscuity. It is this recurring curiosity, as well as the uniformity of the mes...

  10. 消糜阴道泡腾片对大鼠细菌性阴道炎的治疗作用研究%Experimental study on the effect of Xiaomi Vagina Effervescent Tablets on bacterial vaginitis in rats

    姜善玲; 王平; 李百开; 高雁

    2014-01-01

    目的:探讨消糜阴道泡腾片对大鼠细菌阴道炎模型的治疗作用。方法将雌性大鼠随机分为正常对照组、模型组、消糜阴道泡腾片治疗组、氧氟沙星栓剂对照组。除正常对照组外,其余各组大鼠建立细菌性阴道炎模型,成模后给药,末次药后取阴道分泌物涂片染色镜检验;处死大鼠,取阴道组织,进行病理学的检查。结果消糜阴道泡腾片高剂量抗大鼠细菌性阴道炎的总有效率为91.7%,与氧氟沙星栓组比较无统计学意义(P ﹥0.05)。结论消糜阴道泡腾片对大鼠细菌性阴道炎具有显著的治疗作用。%Objective To investigate the therapeutic effects of Xiaomi Vagina Effervescent Tablets on bacteria vaginitis model in rats. Methods Female rats were randomly divided into normal control group,model group,Xiaomi Vagina Effer-vescent Tablets treatment group,Ofloxacin Suppositories control group. Except normal control group,establishment of bacte-rial vaginitis model in the remaining rats,into the mold after the administration,after last administration,vaginal secretion smear staining microscopic examination;The rats were sacrificed,and vaginal tissue was took to carry out pathologic exami-nation. Results The high dose of Xiaomi Vagina Effervescent Tablets in rats with bacterial vaginosis total efficiency was 91. 7% ,there was no statistical significance compared with the Ofloxacin Suppositories group(P ﹥ 0. 05). Conclusion Xiaomi Vagina Effervescent Tablets in the treatment of bacterial vaginosis rats had significantly therapeutic effect.

  11. Vaginoplasty with an Acellular Dermal Matrix Patch for Congenital Absence of Vagina%生物补片人工阴道成形术治疗先天性无阴道

    贡震; 邵振堂; 沈宇飞; 张蕾; 石晓燕; 谭笑梅

    2014-01-01

    Objective To evaluate the clinical application of vaginoplasty with an acellular dermal matrix patch in the treatment of congenital absence of vagina . Methods This retrospective analysis included 21 patients with congenital absence of vagina referred to our department from March 2010 to March 2013.All the patients underwent vaginoplasty at the gap between the rectum and the urethra with an acellular dermal matrix patch .The clinical course and management were reviewed . Results All the 21 patients underwent vaginoplasty with an acellular dermal matrix patch successfully .The vagina mucosa was formed 8 weeks after vaginoplasty with a depth >8 cm and width >3 cm.After follow-up reviews for 9-18 months, a satistactory feedback of sexual life was obtained in 14 patients who had sexual experiences . Conclusion Vaginoplasty with an acellular dermal matrix patch for patients with congenital absence of vagina can be successfully performed with satisfactory outcomes .%目的:探讨生物补片人工阴道成形术治疗先天性无阴道的疗效。方法2010年3月~2013年3月,行生物补片人工阴道成形术治疗21例先天性无阴道,于直肠及尿道膀胱间隙人工造穴,百得塞补片置入造穴腔,并指导患者定期更换模具。结果21例手术均获成功,术后8周人工阴道即完全黏膜化,阴道壁柔软、红润,阴道深度>8 cm,宽度>3横指。随访9~18个月,有性生活患者(14例)性生活满意。结论生物补片人工阴道成形术是治疗先天性无阴道的可行方法。

  12. 复发性外阴阴道假丝酵母菌病发病机制的研究进展%An analysis of the factors contributing to recurrent vulva and vagina candidiasis

    徐倩倩; 宁玉梅

    2013-01-01

    复发性外阴阴道假丝酵母菌病(Recurrent candidiasis of vulva and vagina,RVVC)病因复杂,主要原因有机体免疫防御机制的变化,宿主局部因素,假丝酵母菌的菌群多样性变化等.认识、了解及掌握上述因素,对临床工作者有效防治RVVC起着非常重要作用.

  13. Detection of the Human 70-kD and 60-kD Heat Shock Proteins in the Vagina: Relation to Microbial Flora, Vaginal pH, and Method of Contraception

    Giraldo, P.; Neuer, A.; Ribeiro-Filho, A; Linhares, I; Witkin, S. S.

    1999-01-01

    The expression of the 60-kD and 70-kD heat shock proteins (hsp60 and hsp70) in the vaginas of 43 asymptomatic women of reproductive age with or without a history of recurrent vulvovaginitis (RVV) were compared. Vaginal wash samples were obtained and assayed by enzyme-linked immunosorbent assay (ELISA) for human hsp60 and hsp70. Heat shock protein 70 was not detected in any of the 19 women with no history of RVV, and hsp60 was present in only one woman in this group. In contrast, in the RVV gr...

  14. Clinical observation of filling type suture via vagina on rectocele%经阴道填充式修补术治疗直肠前突的疗效观察

    刘进中; 李俊英

    2012-01-01

    目的 观察经阴道填充式修补术治疗中、重度直肠前突的临床疗效.方法 对21例直肠前突病例资料进行回顾性分析.结果 治愈14例(66.7%),显效4例(19.0%),有效3例(14.3%),无效0例(0.0%).住院13~21 d,无并发症及后遗症.结论 经阴道填充式修补术治疗直肠前突,临床疗效满意,安全可靠,值得临床推广.%Objective To observe the clinical efficacy of filling type suture via vagina on moderate and severe rectoeele (RC). Methods The clinical data of 21 RC patients were retrospectively analyzed. Results Fourteen patients (66.7%) were cured. The therapeutic effect was excellent in 4 patients (19.0%), and good in 3 (14.3%). No ineffective case was recorded. The length of hospital stay was 13 to 21 d with no complications and sequelae. Conclusion The filling type suture via vagina on RC can obtain satisfying clinical outcomes. It's safe, reliable, and worth to be popularized.

  15. Progress in research of vagina micro ecological imbalance in Chinese and Western medicine%阴道微生态失调的中西医研究进展

    王丹丹; 董燕

    2014-01-01

    Vaginal micro ecological imbalance refers to the normal flora imbalance of the vagina, including the result of the impact of external factors , the mutual restraint and interdependent among the original flora to broke the balance , causing abnormal vaginal discharge, genital itching or waist, a gynecological abdominal pain symptoms of vaginitis, vaginal as female genital connection with the outside world the only passage between the environment, the human body is an important micro­ecological zones. Is also an important part of the reproductive tract micro flora. In the vaginal wall mucosal folds and then there is the vault vaginal flora, usually vaginal flora with lactobacilli was the dominant bacteria. Into a variety of lactic acid bacteria, Lactobacillus probiotics for the maintenance of the vagina is important, PH value of the vagina can be maintained in the normal acidic condition, can also inhibit bacteria play a bactericidal effect, in addition to lactic acid bacteria in the vagina outside of further there are fungi, viruses, etc., under normal circumstances, a variety of flora in the vagina interdependent mutual restraint, joint action within the vaginal environment will be maintained at a balanced state, the dominant strain of Lactobacillus, once lost the advantage will lead to other flora overgrowth, breaking the vaginal micro flora balance, leading to female vaginal dysbiosis.%阴道微生态失调是指阴道中的正常的菌群在内因或在外因的影响下出现了菌群之间的失衡,使原来菌群之间的互相制约、互相依赖的平衡关系被打破,从而引起白带异常、外阴瘙痒或是腰部、下腹部疼痛[1]的阴道炎症状的一种妇科疾病。阴道作为连接女性内生殖器与外界环境之间唯一的通道,是人体内重要的微生态区,也是生殖道微生态的重要部分。在阴道的侧壁黏膜、皱襞,而后是穹窿都存在有阴道菌群,通常阴道菌群

  16. 葛石胶囊对去卵巢大鼠子宫和阴道的影响%The effects of Geshi capsule on womb and vagina in ovariectomized rats

    王诗华

    2011-01-01

    目的 明确葛石胶囊对主要分布雌激素α受体的子宫和阴道的影响.方法采用模拟人类妇女绝经期的雌性切除双侧卵巢大鼠模型,随机分成正常组、假手术组、模型组、雌激素组及葛石胶囊大、中、小剂量组.手术后第2周开始给药,持续6周.结果模型组子宫和阴道的湿重及指数明显减少;雌激素可使其增加至正常范围,葛石胶囊各组也可使其有不同程度增加,表现为高于模型组而同时低于正常组.模型组大鼠子宫的体积变小,管壁明显变薄,管腔狭窄,内膜下腺体减少,固有层细胞密集,同时,阴道壁明显变薄,黏膜上皮薄.雌激素组治疗后,子宫和阴道恢复到正常组水平;葛石胶囊大剂量组可部分改善去卵巢大鼠子宫和阴道的变化,但达不到正常组水平.中、小剂量组对所观察指标影响不大.结论葛石胶囊无显著促进去卵巢大鼠子宫和阴道增重及相关细胞增生的作用.提示临床应用葛石胶囊防治更年期妇女骨质疏松、心血管疾病及其能量代谢的同时,其诱发子宫和阴道的不良反应可能远低于雌激素.%OBJECTIVE To clarify the effect of Geshi capsule on womb and vagina, where estrogen a receptor was mainly expressed. METHODS The ovariectomized rats were randomly divided into the normal group, sham - operation group, model group, estrogen group,Geshi capsule with high,middle and low dose groups. Two weeks after surgery,the moded rats were treated for 6 weeks. RESULTS The wet weight and related index in the model group were significantly reduced, and could be increased to the normal range by estrogen. The value of these parameters after treated with Geshi capsule appeared to be higher than model group,but lower than normal group (P < 0.01). The morphology observation demonstrated that the size of womb became smaller and the vagina wall got thinner in model group. The womb and vagina could recover to normal state following

  17. Clinical treatment for vulva vagina candida infection during pregnancy%妊娠期外阴阴道念珠菌感染患者的临床治疗措施研究

    张佳洁; 梁淑青

    2015-01-01

    Objectives:To summarize the clinical treatment and therapeutic efficiency of vulva vagina can-dida infection during pregnancy.Methods:82 pregnancy patients with vulva vagina candida infection treated in our hospital from February 201 2 to August 201 4 were selected and randomly divided into two groups.41 cases in control group received routine therapy,while 41 cases in the experimental group received targeted therapy plan.The thera-peutic efficiency of the two groups was compared.Results:The difference in treatment effect between the two groups was significant (P <0.05).Conclusion:Clinical treatment on clinical pregnancy vulva vagina candida infection must be timely and thorough.More attention should be given to drug choose,so as not to affect the fetus.At the same time,the use of antifungal drugs on the vulva vagina candida infection during pregnancy is prohibited.Vaginal topical drugs are the main choice to minimize influence on the fetus.%目的:总结妊娠期外阴阴道念珠菌感染患者的临床治疗措施与治疗效率。方法:本次研究资料选自2012年2月至2014年8月期间在我院接受诊治的82例妊娠期外阴阴道念珠菌感染患者,随机分成两组。对照组41例研究对象接受常规治疗,而实验组41例研究对象则接受针对性治疗方案,同时对比及分析两组研究对象的治疗情况。结果:两组研究对象在治疗效果方面的比较差异较为显著(P <0.05)。结论:临床上妊娠期外阴阴道念珠菌感染患者的临床治疗必须及时与彻底,并严格把握药物选用环节,以免对胎儿造成影响。同时,妊娠期外阴阴道念珠菌感染患者禁止使用抗真菌类药物,以阴道局部类药物为主要选择,最大限度控制对胎儿的影响。

  18. 妊娠期外阴阴道念珠菌感染患者的临床治疗措施研究%Clinical treatment for vulva vagina candida infection during pregnancy

    张佳洁; 梁淑青

    2015-01-01

    Objectives:To summarize the clinical treatment and therapeutic efficiency of vulva vagina can-dida infection during pregnancy.Methods:82 pregnancy patients with vulva vagina candida infection treated in our hospital from February 201 2 to August 201 4 were selected and randomly divided into two groups.41 cases in control group received routine therapy,while 41 cases in the experimental group received targeted therapy plan.The thera-peutic efficiency of the two groups was compared.Results:The difference in treatment effect between the two groups was significant (P <0.05).Conclusion:Clinical treatment on clinical pregnancy vulva vagina candida infection must be timely and thorough.More attention should be given to drug choose,so as not to affect the fetus.At the same time,the use of antifungal drugs on the vulva vagina candida infection during pregnancy is prohibited.Vaginal topical drugs are the main choice to minimize influence on the fetus.%目的:总结妊娠期外阴阴道念珠菌感染患者的临床治疗措施与治疗效率。方法:本次研究资料选自2012年2月至2014年8月期间在我院接受诊治的82例妊娠期外阴阴道念珠菌感染患者,随机分成两组。对照组41例研究对象接受常规治疗,而实验组41例研究对象则接受针对性治疗方案,同时对比及分析两组研究对象的治疗情况。结果:两组研究对象在治疗效果方面的比较差异较为显著(P <0.05)。结论:临床上妊娠期外阴阴道念珠菌感染患者的临床治疗必须及时与彻底,并严格把握药物选用环节,以免对胎儿造成影响。同时,妊娠期外阴阴道念珠菌感染患者禁止使用抗真菌类药物,以阴道局部类药物为主要选择,最大限度控制对胎儿的影响。

  19. Endoluminal ultrasound and segmental analysis in diagnosis of congenital malformation of the uterus and vagina%腔内超声节段分析法诊断先天性子宫及阴道畸形

    杨雪冰; 王慧芳; 刘云平; 陈秋香; 郭娟; 王诗雅

    2013-01-01

    Objective To investigate the diagnostic value of endoluminal ultrasound (transvaginal and transrectal ultrasound) and segmental analysis with three-dimensional ultrasonography for congenital malformation of the uterus and vagina. Methods A total of 226 patients with clinically confirmed congenital malformations of the uterus and vagina were enrolled and divided into two groups. Group A included 154 cases, the findings of transabdominal or endoluminal two dimensional ultrasonography were retrospectively compared with clinical diagnosis. Group B included 72 cases, the results of segmental analysis by endoluminal three-dimensional ultrasonography were perspective studied and then compared with clinical diagnosis. Results In group A, 99 of 154 cases with congenital malformations of the uterus and vagina were diagnosed by two dimensional ultrasound, while 55 cases were missed or misdiagnosed. The coincidence rate was 64. 29% (99/154). In group B, since the introduction of three dimensional ultrasonography and segmental analysis, 69 of 72 cases were defined, with the coincidence rate of 95. 83% (69/72), while 3 cases were missed diagnosed or misdiagnosed. Conclusion Translu-minal three-dimensional ultrasonography and segmental analysis have essential diagnostic value, which can improve the accuracy of diagnosis and classification of congenital malformation of the uterus and vagina.%目的 探讨应用腔内(经阴道或经直肠)三维超声节段分析法诊断先天性子宫及阴道畸形的价值.方法 将226例先天性子宫及阴道畸形患者分为A、B两组.A组154例,采用回顾性分析,对比分析其经腹或腔内二维超声检查的结果及临床结局;B组72例,采用前瞻性研究,对比分析应用节段分析法经腔内三维超声检查的结果及临床结局.结果 A组154例中,二维超声检查诊断符合率为64.29%(99/154),漏、误诊55例,未进行详细分类;B组72例中,腔内三维超声节段

  20. Relevance between acidic environment of vagina and vulvovaginal Candidiasis%阴道内酸性环境对白色念珠菌性外阴阴道炎治疗的关联研究

    施磊; 宗黎琼; 童剑倩; 郭澄

    2012-01-01

    Objective To explore the relevance between the acidic environment of vagina and vulvovaginal Candidiasis infected by Candida albicans. Methods Ninety-six strains from patients (June 2009 to March 2010) with Simple Gynecological Candida Vulvovaginitis (SVVC) were isolated and identified. The MIC of miconazole and clotrimazole under different pH value of environment were measured. Results The MIC of miconazole or clotrimazole was decreased under lower pH value. Conclusion Keep the acidic environment of vagina is beneficial to the treatment of vulvovaginal Candidiasis infected by Candida albicans.%目的 探讨阴道内酸性环境与白色念珠菌性外阴阴道炎的相关性.方法 分别对2009年6月至2010年3月妇科门诊的单纯性外阴阴道假丝酵母菌病(SVVC)患者进行阴道菌株分离、鉴定,获得白色念珠菌96株.检测不同pH值环境下菌株对硝酸咪康唑与克霉唑的药物敏感性,并观察相关性.结果 在pH值偏酸性的环境下,两种唑类药物的MIC均有不同程度的降低,对白色念珠菌抑菌效果更强.结论 维持阴道内酸性环境能更有效地治疗白色念珠菌性外阴阴道炎.

  1. 剖宫产后阴道分娩35例相关因素分析%Splits the Palace Post-natal Vagina Childbirth 35 Example Correlation Factors to Analyze

    邹清如; 蔡芬兰; 黄利兰; 宋薇

    2012-01-01

      目的 探讨剖宫产术后阴道分娩(VBAV)的相关因素.方法 回顾性分析135例瘢痕子宫孕妇的临床资料,根据分娩方式分为阴道分娩组(实验组)35例和剖宫产组(对照组)100例,对孕妇的一般情况进行调查分析,并在两组之间进行对比.结果 两组产妇在阴道分娩史、前次剖宫产指征、胎龄、新生儿体质量、宫颈条件等方面有统计学差异(P0.05).结论 VBAV与多种因素有关,针对上述相关因素可适时选择阴道分娩,减少剖宫产率,提高产科质量.%  Objective After the goal discussion splits the palace to produce the technique the vagina childbirth (VBAV) correlation factor. Method Review analysis 135example scar womb pregnant woman's clinical material, divides into the vagina childbirth group according to the childbirth way (experimental group) 35 examples and splits the palace to produce the group (control group) 100 examples, carries on the diagnosis to pregnant woman's ordinary circumstances, and carries on the contrast between two groups. Result The two group of parturient women in the vagina childbirth history, recently split the palace to produce refer draft, aspects and so on embryo age, newborn body weight, cervix of the uterus condition have statistics difference (P0.05).Conclusion VBAV and many kinds of factors related, may at the right moment choose the vagina childbirth in view of the above correlation factor, reduces splits the palace production rate, improves obstetrics quality.

  2. The research progress of vagina lactobacillus is associated with cervical lesions%阴道乳杆菌与宫颈病变相关的研究进展

    辛秀团

    2015-01-01

    The cervical lesion is one of the major diseases threatening the health of women, in the context of its incidence, second only to breast cancer in female malignant tumor in the whole world, in some countries even than the breast cancer incidence of a disease. Mainly concentrated in cervical lesions in patients with age between 30 to 45 years old, and as the patient age incidence is obviously rising trend. At home and abroad at present, many scholars believe that the cervical lesions have direct links to the fall in the number of lactobacillus in the vagina, aimed at this situation, this study from the antitumor mechanism and original microbial antagonism disease-resistant two aspects of lactobacillus in the vagina and cervix lesion of correlation analysis, the peers to play the role of reference and reference.%宫颈病变是威胁妇女健康的主要疾病之一,就其发病率来看,在全球女性恶性肿瘤中仅次于乳腺癌,在部分国家中发病率甚至超过了乳腺癌。宫颈病变患者年龄主要集中在30-45岁之间,而且随着患者年龄的增长发病率呈明显上升趋势。目前,国内外诸多学者认为宫颈病变与阴道乳杆菌数量下降有着直接的联系,针对这一现状,本研究从抗肿瘤机制以及拮抗病原微生物两个方面对阴道乳杆菌与宫颈病变的相关性进行分析,希望能够对广大同行起到借鉴与参考的作用。

  3. MRI of the uterus, uterine cervix, and vagina: diagnostic performance of dynamic contrast-enhanced fast multiplanar gradient-echo imaging in comparison with fast spin-echo T2-weighted pulse imaging

    The aim of this study was to compare the diagnostic performance of contrast-enhanced fast multiplanar gradient-echo (GRE) and T2-weighted fast spin-echo (FSE) image sets in the assessment of uterus, cervix, and vagina. Fast (up to 20 contiguous sections in 23 s) multiplanar GRE and FSE images of 45 patients referred for imaging of the female pelvis were evaluated retrospectively with regard to overall image quality and the ability to detect normal anatomic structures, as well as lesion conspicuity. Results were compared with histologic findings (n = 29) or clinical follow-up. Furthermore, a quantitative assessment of contrast-to-noise ratios among normal uterine and cervical structures as well as uterine lesions was performed for both sequences. On GRE images, uterine and cervical differentiation was best seen on the image sets acquired 15 and 60 s following contrast enhancement and results were significantly better compared with delayed images (p 2 test, the difference in diagnostic performance between FSE and GRE revealed no significant difference, whereas the combination of both techniques performed better than FSE imaging alone (p < 0.05). The presented data suggest that dynamic contrast-enhanced GRE imaging should be part of an MR examination of the female pelvis. Combined GRE and FSE imaging provide an excellent sensitivity in the assessment of uterine and vaginal pathologies. (orig.) (orig.)

  4. Citologia Hormonal do Trato Urinário Baixo e da Vagina de Mulheres na Pós-menopausa, antes e durante Estrogenioterapia Oral e Transdérmica Urinary and Vaginal Cytology of Postmenopausal Women with Oral and Transdermal Estrogen Replacement

    Áurea Belas Lustosa; Manoel João Batista Castello Girão; Marair Gracio Ferreira Sartori; Edmund Chada Baracat; Geraldo Rodrigues de Lima

    2002-01-01

    Objetivo: avaliar a ação dos estrogênios por via oral ou transdérmica nas células do trato urinário baixo e da vagina, em mulheres menopausadas. Métodos: foram incluídas 25 mulheres na pós-menopausa, nas quais se estudaram os efeitos citológicos da terapia de reposição hormonal estrogênica, por via oral e por via transdérmica, sobre as células da vagina e do sedimento urinário. As pacientes foram distribuídas aleatoriamente em 2 grupos: Grupo I, constituído por 14 mulheres que receberam 0,625...

  5. 益母草颗粒剂及血府逐瘀冲剂对减少药物流产后阴道出血的临床研究%Yimucao drop preparation and Xue fuzhuyu oral juice for reduction of vagina bleeding caused by medicine aborting

    王蕊; 胡燕琴

    2001-01-01

    目的:用中药治疗减少药物流产后阴道出血量及缩短阴道出血时间。方法:将150例病人随机分组,分别用益母草冲剂及血府逐瘀冲剂治疗流产后阴道出血。结果:单剂益母草颗粒剂及血府逐瘀冲剂对减少流产后阴道出血持续时间及出血量无临床差异,但二者合剂却能明显缩短出血时间及减少出血量。结论:复方合剂中药制剂对减少药物流产后阴道出血量及缩短出血时间有良好的临床效果。%Objective: medicine treatment for reducing vagina bleeding caused by medicine aborting. Method: 150 patients are at ranclom divided in to two groups given yimuco drop preparation and xuefuzhuyu oral juice to treat the vagina bleeing caused by medicine aborting, respectively. Results: There was no difference in reducing the lasting time and the amount of vagina bleeding caused by medicine aborting if either of the two drug alone was used. However, both of them used together showed better a treatment effect. Conclusion: The combination of the two chinese medicines has a very best clinice effect for reducing the lasting time and the amount of vagina bleeding after medicine aborting.

  6. Posterior Pelvic Exenteration and Plastic Operation of Vagina Constituted from the Sigmoid Flexure for Rectal Carcinoma Treatment in Female Patients%后盆脏器切除带蒂乙状结肠阴道修复术治疗女性直肠癌

    匡毅; 李福沛; 蒋又新; 赵和照

    2012-01-01

    Objective: This work aims to investigate the method and significance of postoperative restitution after pelvic exenteration on female rectal cancer patients. Methods: Since 1996, 49 cases of female rectal cancer underwent posterior pelvic exenteration in the Chongqing Cancer Institute. These patients received plastic operation of the vagina that was constituted from the sigmoid flexure. The pre-sacral space was simultaneously filled by the greater omentum. Primary suture of the perineum was performed in 34 out of 49 cases. Results: The reconstructed vaginas have a width of two fingers, a depth between 8 and 10 cm, and a smooth, soft, and lustrous quality. Their shape and localization were the same as those of the original vaginas, and the patients revealed they have satisfied sexual life and improved bladder function without dysuresia. Conclusion: mThe structural defect of the vagina was eliminated after posterior pelvic exenteration and plastic operation. The sexual function of the vagina was maintained, and the quality of life of the patients improved.%目的:探讨女性后盆腔脏器切除术后盆底结构重建的方法和意义.方法:1996年3月至2009年1月重庆市肿瘤研究所行女性后盆腔脏器切除术(posterior pelvic exenteration) 49例,其中采用移植带血管蒂乙状结肠作阴道成形,并以大网膜充填骶前间隙,一期缝合会阴切口34例.结果:再造阴道可容两指,长度8~9cm,壁光滑、柔软、润泽,形体位置与原阴道相近.患者性生活无障碍,膀胱功能良好,无排尿困难.结论:本术式弥补了直肠癌后盆切除术盆底结构缺损处理困难的缺陷,保留患者的性功能,提高了患者术后生存质量.

  7. 臭氧液阴道冲洗治疗假丝酵母菌病的疗效观察%Efficacy of douching vagina with ozone liquid in treatment of vulvovaginal candidiasis

    罗翠华; 陈晓燕; 李伟妙; 罗建华

    2014-01-01

    目的:观察单纯臭氧灭菌液配合改良阴道冲洗和臭氧液直接阴道内冲洗配合阴道给药两种不同方法的临床疗效,为进一步改进假丝酵母菌病的治疗方法提供依据。方法将2008年6月-2012年10月200例确诊外阴阴道假丝酵母菌病的患者随机分成两组,观察组100例采用单纯臭氧灭菌液配合改良阴道冲洗治疗,每天1次,疗程3 d;对照组100例采用臭氧液直接阴道内冲洗配合达克宁栓阴道给药,每天1次,疗程3 d ,每次冲洗前进行临床、真菌学疗效分析,比较两组的疗效及不良反应。结果治疗3 d后,观察组痊愈率达到91.0%,总有效率达98.0%;对照组痊愈率达57.0%,总有效率达81.0%;观察组症状缓解时间明显短于对照组,两组比较差异有统计学意义(P<0.05)。结论单纯臭氧灭菌液配合改良阴道冲洗治疗外阴阴道假丝酵母菌病疗效好,并且操作简单安全、不良反应少,患者容易接受,值得在临床中推广使用。%OBJECTIVE To observe the clinical curative effect of the treatment of vulvovaginal candidiasis by using pure ozone sterilizing liquid with modified vaginal douche compared with the method of douching the vagina with ozone liquid and vaginal drug delivery ,so as to providing evidence to modify the treatment of vulvovaginal candidi-asis further .METHODS Totally 200 cases of patients with vulvovaginal candidiasis in Jun 2008 to Oct 2012 were randomly divided into two groups .The 100 patients of observation group were treated with pure ozone sterilizing liquid with modified vaginal douche ,1 d ,period of treatment 3 d .The 100 patients of control group was treated by douching the vagina with ozone liquid directly and applying miconazole suppository ,1 d ,period of treatment 3 d .Each time the clinical and mycological efficacy were analyzed before treatment and the efficacy and adverse reac-tions were compared between

  8. 妊娠期外阴阴道假丝酵母菌病症状与妊娠结局分析%Vulva Vagina Candida Disease Symptoms During Pregnancy and Pregnancy Outcome Analysis

    莫培培

    2014-01-01

    目的:研究妊娠期外阴阴道假丝酵母菌病(VVC)症状与妊娠结局的关系。方法选取我院收集的136例妊娠>35 w患者阴道分泌物假丝酵母菌涂片阳性诊断VVC,其中有症状者60例作为观察组,无症状者76例作为对照组。观察两组妊娠结局及不良妊娠结局情况。结果观察组胎膜早破、产褥感染和剖宫产率与对照组比较差异有统计学意义(0.05)。结论妊娠期有症状VVC可致胎膜早破、剖宫产率等不良妊娠结局增高,早期诊断和治疗十分必要。%Objective To study the pregnancy vulva vagina candida disease symptoms and the relationship between pregnancy outcome (VVC). Methods Selected our hospital's col ection of 136 patients older than 35 weeks pregnancy vaginal candida smear positive diagnosis of VVC, including symptoms in 60 patients as observation group, asymptomatic 76 cases as control group. Observation two groups of pregnancy outcome and adverse pregnancy outcomes. Results The observation group of premature rupture of membranes, puerperal infection and cesarean section rate compared with control group dif erence was statistical y significant ( 0.05). Conclusion Symptomatic VVC during pregnancy can cause premature rupture of membranes, cesarean section rate increased and other adverse pregnancy outcomes, early diagnosis and treatment is necessary.

  9. Sarcoidosis of the vagina treated with methotrexate.

    Şahin, N; Solak, A; Karaarslan, S; Doruk, S

    2016-06-01

    We describe the first case of mediolateral episiotomic sarcoidosis of the deep vaginal tissue, without involvement of the pulmonary parenchyma or pulmonary symptoms. A 68-year-old female was admitted with a vaginal mass that had developed about 1 month prior. On bimanual examination, we found a painful solid mass approximately 4 cm in diameter on the episiotomy line of the deep vaginal tissue. The patient underwent pelvic magnetic resonance imaging on suspicion of a malignancy, and a vaginal true-cut biopsy was performed. The biopsy specimen exhibited non-caseating, granulomatous inflammation and many multinucleated giant cells, strongly suggesting sarcoidosis. We had excluded other granulomatous diseases; a final diagnosis was made of stage-1 sarcoidosis in the deep vaginal mass. A 3-month course of methotrexate (2.5 mg/week) was commenced to treat a flare-up of rheumatoid arthritis. The vaginal mass resolved. To the best of our knowledge, this is the first case of sarcoidosis in a deep vaginal mass without pulmonary parenchymal or other solid-organ involvement. PMID:26624970

  10. Alanine transport across in vitro rabbit vagina.

    Hajjar, J J; Mroueh, A M

    1979-04-01

    Transmural flux of alanine across the vaginal epithelium of the rabbit is a specialized mechanism. There is a net serosal to mucosal translocation of the amino acid in the absence of a concentration gradient. Changes in reproductive cycle do not influence this mechanism but, in castrated animals, it is abolished. Transport properties of vaginal epithelium is important because of increasing utilization of intravaginal contraceptives. PMID:455986

  11. Relationship of microecological environmental changes of vagina and two kinds of vaginitis%女性阴道微生态变化与两种阴道炎的关系

    杨岚; 邵兰芬; 陈道桢

    2011-01-01

    Objective To investigate the relationship of microecological environment of vagina and vulvovaginal candidiasis (VVC) and trichomonas vaginitis (TV) of women. Methods The examinations of hydrogen peroxide, sialidase and leukocyte esterase in vaginal secretions were performed with routine smear and BV triple test in 2380 cases with WC (group WC), 1399 cases with TV( group TV) and 648 healthy controls (group C). Results The positive rates of leukocyte esterase in groups of WC and TV were 34. 7% and 61. 5% .respectively,which were both higer than 6. 6% in group C(P<0. 05). The positive rate was higher in group TV than that in group VVC (P<0. 05). Conclusion The occurance of WC and TV is closely related to the unbanlance of vaginal microecological environment Examining vaginal secretions with routine smear and Bvset, especially with leukocyte esterase test,should be taken for guiding the microecological evaluation and controlling the recurrence of vaginitis.%目的 了解外阴阴道假丝酵母菌病(VVC)及滴虫性阴道炎(Tv)与阴道微生态情况的关系.方法 用常规检测和细菌性阴道病(BV)三联法(BVset)测定2380例WC(WC组)、1399例TV患者(TV组)和648例正常体检者(对照组)阴道分泌物中过氧化氢(H2O2)浓度、唾液酸苷酶和白细胞酯酶活性.结果 VVC和TV患者三联法检测白细胞酯酶阳性率分别为34.7%和61.5%,明显高于对照组的6.6%(P<0.05);且TV组的白细胞酯酶阳性率显著高于WC组(P<0.05).结论 VVC和TV的发生与阴道微生态环境的失衡密切相关;对患者进行白带常规检测的同时进行BVset尤其是白细胞酯酶活性测定,能更好地反映出患者阴道微生态状况,对控制阴道炎的复发有一定的指导意义.

  12. 保妇康栓联合乳酸菌阴道胶囊治疗妊娠期霉菌性阴道炎的临床效果%the Clinical Effect of Baofukang suppository Combined Lactobacillus Vagina Capsule Treatment Mould Sex Vaginitis During Pregnancy

    2013-01-01

    Objective Baofukang suppository combined lactobacillus vagina capsule treatment, the clinical effect of mould sex vaginitis during pregnancy. Methods Will be 100 cases of clinically diagnosed with mould sex vaginitis were randomly divided into observation group and control group 50 cases each, observation group was given Baofukang suppository combined lactobacillus vagina capsule treatment, control group given bao fu kang treatment, compare the curative effect of two groups of patients. Results Group the cure rate is 90%; Control group cure rate was 74%, the observation group is significantly higher than the control group, two groups of comparisons, the difference was statistically significant (P<0.05). Conclusion Baofukang and lactobacillus vagina capsule combined treatment curative effect is mould sex vaginitis, worthy of clinical application widely.%  目的保妇康栓联合乳酸菌阴道胶囊治疗妊娠期霉菌性阴道炎的临床效果。方法将100例经临床确诊的霉菌性阴道炎患者随机分为观察组和对照组各50例,观察组给予保妇康栓联合乳酸菌阴道胶囊治疗,对照组给予保妇康治疗,比较两组患者的治疗效果。结果组治愈率为90%;对照组治愈率为74%,观察组显著高于对照组,两组比较,差异具有统计学意义(P<0.05)。结论保妇康与乳酸菌阴道胶囊联合治疗霉菌性阴道炎疗效确切,值得临床广泛应用。

  13. 心理干预对先天性无阴道患者术后婚姻和生活质量的影响%The influence on the quality of marital and life in the congenital absence of vagina patients with operation by psychological intervention

    张晓玲; 朱清仙

    2008-01-01

    目的 探讨心理干预对先天性无阴道患者术后婚姻和生活质量的影响.方法 将先天性无阴道患者按自愿原则分为干预组18例和非干预组11例,对干预组的患者进行术前的认知行为治疗,用Olson婚姻质量调查问卷及诺丁汉健康量表对两组手术前后生活质量以及术后婚姻质量进行评估.结果:干预组术后婚姻和生活质量评分均显著优于非干预组(P<0.05或P<0.01).结论 手术前心理干预能有效提高先天性无阴道患者术后婚姻和生活质量.%Objective To explore the influence on the quality of marital and life of the congenital absence of vagina patients with operation by psychological intervention.Methods The congenital absente of vagina patients were divided into psycholOgical intervened group(n=18,all cases were treated with the cognitive and behaviour therapy)and without intervened group(n=11).Before and after treatment the scores of the nottingham health poofity(NHP)were used in the two groups.After treatment the Olson's enrich questionary were tested also.Results The scores of NHP and Olson of psychological intervened group were significantly superior to those without intervened group(P<0.05 or P<0 01).Conclusion The cogntive and behaviour theraopy before operation is good for the quality of marital and life in congenital absence of vagina patients.

  14. 25%足叶草酯溶液外涂治疗85例阴道及宫颈尖锐湿疣的效果%Coating 25% Podophyllotoxin Liquid on the Vagina and Cervix Uteri Area for Treating the Verruca Acuminate:85 Case Reports

    张淑芳; 刘品娟; 陈海针

    2015-01-01

    Objective To develop an efifcient method for treating the verruca acuminate on the vagina and cervix uteri area. To analyze the safety and effectiveness of using the 25% podophyllotoxin on the vagina and cervix uteri area.Methods Dipping the 25% podophyllotoxin on the warts. Controlling the dose less than 0.5 mL. Dipping less and superifcially.Results The warts of Eighty-ifve patients were disappeared after the treatment. Five patients were found relapsing in a month. Given the same treatment once, the warts disappeared.Conclusion The method of using the 25% podophyllotoxin on the vagina and cervix uteri area for treating the verruca acuminate is a efifcient safe and non-invasive treatment.%目的:探讨治疗阴道及宫颈尖锐湿疣的有效方法,分析阴道和宫颈使用25%足叶草酯溶液治疗的安全有效性。方法点蘸25%足叶草酯溶液至疣体局部,每次用量控制在0.5 mL内,药液使用少而浅。结果85例患者在治疗后复诊皮损均消退,有5例在1个月后复查有复发,再予相同治疗使用一次后,皮损均消退。结论使用25%足叶草酯溶液外涂治疗阴道和宫颈尖锐湿疣,是一种有效,安全,无创的治疗方法。

  15. 保妇康栓联合乳酸菌阴道胶囊治疗妊娠期霉菌性阴道炎的临床效果%the Clinical Effect of Baofukang suppository Combined Lactobacillus Vagina Capsule Treatment Mould Sex Vaginitis During Pregnancy

    2013-01-01

      目的保妇康栓联合乳酸菌阴道胶囊治疗妊娠期霉菌性阴道炎的临床效果。方法将100例经临床确诊的霉菌性阴道炎患者随机分为观察组和对照组各50例,观察组给予保妇康栓联合乳酸菌阴道胶囊治疗,对照组给予保妇康治疗,比较两组患者的治疗效果。结果组治愈率为90%;对照组治愈率为74%,观察组显著高于对照组,两组比较,差异具有统计学意义(P<0.05)。结论保妇康与乳酸菌阴道胶囊联合治疗霉菌性阴道炎疗效确切,值得临床广泛应用。%Objective Baofukang suppository combined lactobacillus vagina capsule treatment, the clinical effect of mould sex vaginitis during pregnancy. Methods Will be 100 cases of clinically diagnosed with mould sex vaginitis were randomly divided into observation group and control group 50 cases each, observation group was given Baofukang suppository combined lactobacillus vagina capsule treatment, control group given bao fu kang treatment, compare the curative effect of two groups of patients. Results Group the cure rate is 90%; Control group cure rate was 74%, the observation group is significantly higher than the control group, two groups of comparisons, the difference was statistically significant (P<0.05). Conclusion Baofukang and lactobacillus vagina capsule combined treatment curative effect is mould sex vaginitis, worthy of clinical application widely.

  16. Colpoplasty by the Nympha Flap for the Treatment of Congenital Atresia of Inferior Vagina%小阴唇皮瓣法阴道成形术治疗阴道下段闭锁9例临床分析

    杨春燕; 吴晓芳

    2012-01-01

    目的 探讨小阴唇皮瓣法阴道成形术在治疗先天性阴道下段闭锁的临床效果.方法 回顾分析我院1994年1月-2011年11月收治的9例先天性阴道下段闭锁患者采用小阴唇皮瓣阴道成形术治疗的临床资料.结果 所有手术均获成功,所形成的阴道通畅,光滑湿润弹性好,所有病人月经正常,痛经缓解,性生活满意,有4例正常分娩.结论 小阴唇皮瓣法阴道成形术方法简便,效果好,是治疗先天性阴道下段闭锁良好的方法,值得临床推广应用.%Objective To explore the clinic effects of colpoplasty by the nympha flap for the treatment of congenital atresia of inferior vagina. Method The clinical data was retrospectively studied of 9 patients with congenital atresia of vagina treated by nympha flap colpoplasty. Results The follow-up results showed all the operations were successful without colpostenosis. The reconstructed vaginas were moist, elastic and smooth. The menstruation cycle was normal. The couples had satisfactory sex life and 4 cases achieved normal pregnancy and delivery. Conclusion It is recommended of the nympha flap colpoplasty for congenital gynatresia of simple operation and good efficacy.

  17. The Application of Paries Anterior Vagina Muscularis Mucosal Flap in the Repairat/on of Female Complicated Urethrovaginal Fistula%阴道前壁肌黏膜瓣在女性复杂性尿道阴道瘘修补术中的应用

    罗道升; 米其武; 戴宇平; 邓春华

    2009-01-01

    Objective To explore the application of the paries anterior vagina U shape muscularis mucosal flap for the repairing of female complicated urethrovaginal fistula. Methods Fifteen complicated urethrovaginal fistulas patients resulted from severe pelvic frac-ture and with history of failing repairing urethrovaginal fistulas were analyzed retrospectively. The mean diameter of maximum urethrovagi-nal fistula was approximately 2.3 cm. The parias anterior vagina U shape mucosal flaps were used to repair the urethrovaginal fistulas, and the paries anterior vagina muscularis mucosae were used to cover the fistulas surface again. Results Fifteen patients were followed up for 6 to 80 months, and they gained normal voiding, with no urine leakage, urinary incontinence and urethra] stricture occurring. Conclusion The paries anterior vagina U shape mucosal flap is an effective technique for repairing complicated urethrovaginal fistula.%目的 探讨阴道前壁U形肌黏膜瓣修补复杂性尿道阴道瘘的应用价值.方法 分析复杂性尿道阴道瘘患者15例,均为车祸至严重骨盆骨折合并尿道阴道瘘,年龄18~56岁,平均31岁.病程2~16个月,平均7.5个月.瘘口大小1.1 cm×2.0 cm~1.5 cm ×2.5 cm,瘘口最大直径平均约2.3cm.有1次尿瘘修补手术史10例、有2次以上修补手术史5例.采用阴道前壁U形黏膜瓣翻转修补瘘口,阴道前壁肌黏膜层覆盖加固瘘口处创面.结果 15例患者术后随访6个月~80个月,均获正常排尿,无尿漏及尿失禁,无尿道狭窄.结论 阴道前壁U形黏膜瓣翻转术操作简单,成功率高,是一种修补复杂性尿道阴道瘘的有效方法 .

  18. 直肠黏膜环切术联合阴道后壁修补术和自拟通便方在治疗女性直肠前突型便秘的应用%The application of procedure for prolapse and hemorrhoids with vagina posterior wall repair and laxative in the treatment of female rectocele constipation

    宋健健; 辛学知; 许媛慧

    2016-01-01

    ObjectiveTo observe the clinical efficacies of procedure for prolapse and hemorrhoids with vagina posterior wall repair and laxative in the treatment of female rectocele constipation. Methods30 cases of female rectocele patients were treated with procedure for prolapse and hemorrhoids with vagina posterior wall repair and laxative. The effect and complications were observed.ResultsThe treatment effective rate was 96.67%, including 86.67% curative rate, the invalid rate was 3.33%. No postoperative infection, bleeding and rectovaginal fistula. Patients were followed up for 12 months to 18 months, All patients′symptoms were significantly alleviated except for one patient with defecation problems and feeling of anal pendant expansion.ConclusionsThe effect of prolapse and hemorrhoids with vagina posterior wall repair and laxative is significant, with low postoperative complications and recurrence rate, it was of worthy for promotion.%目的:观察女性直肠前突型便秘患者行直肠粘膜环切术(procedure for prolapse and hemorrhoids)+阴道后壁修补术(vagina posterior wall repair)联合自拟通便方治疗后的临床疗效。方法选取30例直肠前突女性患者,采用直肠粘膜环切术+阴道后壁修补术联合自拟通便方的方法治疗,观察此方法的有效率及术后并发症。结果此方法治疗的有效率为96.67%,其中痊愈率86.67%,无效率为3.33%。术后均未出现感染、出血及直肠阴道瘘等。术后随访12个月至18个月,除1例患者仍存在排便困难伴肛门坠胀感,余患者不适症状均有明显缓解。结论直肠粘膜环切术+阴道后壁修补术联合自拟通便方安全有效,效果显著,术后并发症及复发率低,值得推广。

  19. Laparoscopically sigmoid colon vaginoplasty in women with congenital absence of vagina: 11 cases report%全腹腔镜乙状结肠代阴道成形术治疗先天性无阴道11例临床分析

    涂春华; 蔡丽萍; 刘丝荪

    2011-01-01

    [Objectives] To evaluate the functional outcomes and technical feasibility of laparoscopically sigmoid colon vaginoplasty in women with congenital absence of vagina. [Methods] Clinical data of eleven women with congenital absence of vagina treated by laparoscopically sigmoid colon vaginoplasty were retrospectively analyzed. A record was made of operating time, bleeding volume, postoperative complications, anatomical and functional outcomes of artificial vagina. [Results] The mean operating time was 143.7 min and the mean bleeding volume was 123.7 mLr There were no significant postoperative complications and all women and their partners were satisfied with the subsequent sexual activity. [Conclusions] Laparoscopically sigmoid colon vaginoplasty is a feasible, safe and effective approach for women with congenital absence of vagina.%目的 分析全腹腔镜乙状结肠代阴道成形术的临床疗效,探讨其安全性及有效性.方法 回顾性分析11例运用全腹腔镜乙状结肠代阴道成形术治疗先天性无阴道患者的临床资料.观察11例全腹腔镜乙状结肠代阴道成形术的手术时间、出血量、术后并发症及人工阴道的解剖学、功能学结果.结果 11例全腹腔镜乙状结肠代阴道成形术均获得成功,平均手术时间143.7 min,平均出血量123.7 mL,新形成的阴道形态上接近正常阴道,患者性生活感觉满意,无术中及术后并发症发生.结论 全腹腔镜乙状结肠代阴道成形术是治疗先天性无阴道患者理想、安全且有效的阴道成形方法.

  20. Prevalência de cândida na flora vaginal de mulheres atendidas num serviço de planejamento familiar Prevalence of candida in the vagina of women attended at a family planning service

    Antônio Aleixo Neto

    1999-01-01

    Full Text Available RESUMO Objetivo: avaliar a prevalência de Candida sp. e a distribuição de suas espécies na flora vaginal de mulheres numa clínica de planejamento familiar. Método: estudo transversal no qual se avaliaram prospectivamente 72 mulheres não-grávidas, com ou sem queixas específicas, sendo coletadas amostras de secreção vaginal para cultura de leveduras, efetuada a medição do pH vaginal e anotados dados de achados do exame ginecológico. Resultados: leveduras pertencentes ao gênero Candida foram encontradas em 18 casos (25%. A C. albicans foi a espécie mais prevalente (77,8% e conseqüentemente 22,2% foram não-albicans. Entre as não-albicans a espécie mais prevalente foi a C. glabrata (16,7% seguida pela C. parapsilosis (5,6%. Prurido e ardor foram os únicos sintomas relacionados significativamente com a presença de cândida. Foi observado que a C. glabrata, ao contrário da C. albicans, não causa corrimento clinicamente verificável ao exame ginecológico. Não foram verificadas associações de alguns fatores predisponentes (idade, escolaridade e uso de contraceptivos com a presença ou não de cândida. Conclusões: nossos resultados sugerem: a uma alta prevalência de Candida sp. entre as mulheres (25%; b que as espécies não-albicans desempenham um papel importante no meio vaginal; c que prurido e ardor são os sintomas mais comuns na presença de cândida e d que a C. glabrata não costuma causar corrimento vaginal ao exame ginecológico. Finalmente, é importante observar que nossos resultados são consistentes com o que a literatura internacional tem mostrado nos últimos anos.SUMMARY Purpose: to estimate the prevalence of Candida sp. and the distribution of its species in the vagina of women attended at a family planning Service. Methods: a cross-sectional study evaluating prospectively 72 nonpregnant women, with or without specific complaints. Samples were checked for the presence of yeast and vaginal pH. Data obtained

  1. A randomized comparison of the laparoscopic peritoneal vaginoplasty and laparoscopic auxiliary sigmoid colon colpopoiesis techniques for congenital absence of vagina%腹腔镜腹膜代阴道成形术和乙状结肠代阴道成形术治疗先天性无阴道临床疗效比较

    曹莉莉; 徐惠成

    2012-01-01

    Objective To evaluate the therapeutic results of the laparoscopic peritoneal vaginoplasty and laparoscopic auxiliary sigmoid colon colpopoiesis procedures for congenital absence of vagina. Methods A single-center, random control study was carried out in 40 patients with congenital absence of vagina. According to random number table method, patients were randomized in 1 :2 ratio to received vaginal angioplasty, in which congenital absence of vagina under laparoscopic auxiliary sigmoid colon vaginoplasty 14 cases, laparoscopic peritoneal generation vaginal angioplasty 26 cases. Both surgical perioperative parameters and effects were investigated. Results All surgical procedures were successfully completed in laparoscopic surgery. Compared with the laparoscopic sigmoid vaginal replacement, laparoscopic vaginal reconstruction using peritoneum approach seems to be superior in perioperative parameters. The procedure is faster and less blood loss, postoperative course was uneventful and postoperative hospital stay days were lower than the laparoscopic-as-sisted sigmoid vagina (P 0.05). Conclusion For patients with congenital absence of vagina, the laparoscopic peritoneal vaginoplasty and the sigmoid colpopoiesis are safe, and reliable method for the correction of vaginal abnormalities. However, the laparoscopic peritoneal vaginoplasty is more invasive, retrieval time faster after surgery.%目的 探讨腹腔镜腹膜代阴道成形术和乙状结肠代阴道成形术的临床疗效.方法 采用随机对照的研究方法,对2001年1月至2010年12月第三军医大学附属西南医院40例先天性无阴道患者按随机表法,1:2随机化分组,分别接受腹腔镜乙状结肠代阴道成形术(14例)和腹膜代阴道成形术(26例),比较2组的围手术期参数及术后疗效.结果 40例患者均在腹腔镜下成功完成手术,腹膜代阴道组较乙状结肠代阴道组手术时间短,术中出血量少,术后恢复快(P<0.05).术后随访6~108个月,

  2. 凯妮汀联合定君生治疗妊娠期外阴阴道假丝酵母菌病的临床观察%Clinical Observation of Canesten Joint Born on Jun Treatment during Pregnancy Vulva Vagina Candida Disease

    陈娟

    2015-01-01

    Objective:To observe clinical effect of canesten clotrimazole vaginal tablet joint born on jun(vagina lactobacillus bacteria live capsule)treating vulva vagina candida disease during pregnancy(VVC). Method:60 cases of pregnancy VVC pregnant women were divided into research group and the control group. Control group was given routine treatment,canesten 1 piece of 0.5 g,deep into the vagina,use before bedtime,single drug used. Research group was given the conventional treatment,canesten 1 piece of 0.5 g,deep into the vagina,used before bedtime,single drug use. 4 days to give born on jun 1 grain of deep in the vagina,used before sleep every night,7 days in a row. The two groups before and after the treatment of vaginal cleanness,vaginal pH value and the cure rate were compared,the therapeutic effect was observed. Result:The vaginal cleannessⅠ-Ⅱdegrees accounted for 90.00%,the cure rate was 90.00%of research group after the treatment,cleanlinessⅠ-Ⅱdegrees accounted for 66.67%,the cure rate was 66.67%of control group.The vaginal pH value before and after treatment comparison difference was statistically significant(P<0.05). Conclusion:For pregnancy VVC,on the basis of antifungal therapy combined with lactobacillus preparation namely canesten joint born on jun can yet be regarded as a kind of curative effect of treatment,clinical popularization value.%目的:观察凯妮汀(克霉唑阴道片)联合定君生(阴道用乳杆菌活菌胶囊)治疗妊娠期外阴阴道假丝酵母菌病(VVC)的临床效果。方法:将60例妊娠期VVC的孕妇分为研究组及对照组。对照组按常规治疗,凯妮汀1片0.5 g,置于阴道深部,睡前使用,单次用药。研究组按常规治疗,凯妮汀1片0.5 g,置于阴道深部,睡前使用,单次用药;第4天再给予定君生1粒置于阴道深部,每晚睡前使用,连续7d。比较两组治疗前后的阴道清洁度、阴道pH值及治愈率,观察其治疗效

  3. Citologia Hormonal do Trato Urinário Baixo e da Vagina de Mulheres na Pós-menopausa, antes e durante Estrogenioterapia Oral e Transdérmica Urinary and Vaginal Cytology of Postmenopausal Women with Oral and Transdermal Estrogen Replacement

    Áurea Belas Lustosa

    2002-10-01

    Full Text Available Objetivo: avaliar a ação dos estrogênios por via oral ou transdérmica nas células do trato urinário baixo e da vagina, em mulheres menopausadas. Métodos: foram incluídas 25 mulheres na pós-menopausa, nas quais se estudaram os efeitos citológicos da terapia de reposição hormonal estrogênica, por via oral e por via transdérmica, sobre as células da vagina e do sedimento urinário. As pacientes foram distribuídas aleatoriamente em 2 grupos: Grupo I, constituído por 14 mulheres que receberam 0,625 mg de estrogênio conjugado eqüino associado a 5 mg de acetato de medroxiprogesterona, por via oral, diariamente sem intervalo por três meses, e Grupo II, formado por 11 mulheres que fizeram uso de 17-beta-estradiol matricial na dose de 50 mig, por via transdérmica, semanalmente, associado a 5 mg de acetato de medroxiprogesterona diariamente por três meses. As amostras urinárias foram obtidas do jato inicial da primeira urina da manhã, após asseio dos genitais, em frascos estéreis fornecidos pelo laboratório. A urina foi centrifugada e o esfregaço realizado a partir do sedimento urinário. Os esfregaços da vagina e do sedimento urinário foram imediatamente fixados em álcool absoluto e corados pelo método de Shorr. Resultados: observou-se que nas pacientes que utilizaram a via oral, houve maturação das células da vagina (o índice se elevou de 45,4 a 65,5 com dois meses de tratamento, permanecendo praticamente constante (62,0 a seguir. Quanto às células urinárias, não houve variação do valor de maturação (56,4 antes da medicação e 60,4 no final do período. Ao examinarmos tanto as células da urina quanto da vagina de pacientes que utilizaram a via transdérmica, notou-se que houve resposta satisfatória. Conclusão: com estes resultados podemos sugerir que os estrogênios, quando administrados por via transdérmica, estão associados à resposta satisfatória quanto ao trofismo tanto na vagina quanto na uretra

  4. 硝酸咪康唑栓与阴道冲洗联合治疗复发性外阴阴道假丝酵母感染的临床疗效%Clinical Curative Effect Analysis of Nitric Acid Health Thiazole Microphones and Vagina Washing Joint Bolt on the Treatment of Recurrent Vulvovaginal Candidiasis Candida Yeast Infection

    杨建庆; 张跃

    2013-01-01

    Objective: To study the health thiazole bolt and nitric acid microphones vagina washing joint on the treatment of recurrent vulvovaginal candidiasis candida mycoderma bacteria the treatment effect of the disease. Methods: 252 were our cases of recurrent vulvovaginal candidiasis candida mycoderma bacteria patients average divided into two groups, the observation group using nitric acid health thiazole microphones bolt joint vagina washing method treatment group using clotrimazole suppositories treatment, compared to two groups curative effect. Results: The observation group the cure rate of 91.3%; The control group cure rate was 57.9%. Significant difference (P< 0.05). Conclusion:Mi nitric acid health thiazole bolt and vagina washing joint on the treatment of recurrent vulvovaginal candidiasis candida mycoderma bacteria disease treatment effect is remarkable.%  目的:探讨硝酸咪康唑栓与阴道冲洗联合治疗复发性外阴阴道假丝酵母菌病的治疗效果。方法:将我院2009年3月~2012年6月期间收治的252例复发性外阴阴道假丝酵母菌病患者平均分为两组,对照组患者采用克霉唑栓剂治疗,观察组患者使用硝酸咪康唑栓与阴道冲洗法联合治疗,然后比较两组的临床疗效。结果:观察组的治愈率达91.3%;对照组的治愈率为57.9%。组间差异具有统计学意义(P<0.05)。结论:硝酸咪康唑栓与阴道冲洗联合治疗复发性外阴阴道假丝酵母菌病具有较高的临床疗效。

  5. From a Script to a Movement——Development Course of the Feminism Drama "The Vagina Monologue"%从剧本走向运动——论女性主义先锋剧《阴道独白》的发展历程

    石艺

    2012-01-01

    《阴道独白》不仅是一部女性主义先锋剧,更掀起了一场女性主义运动:作为一部剧本,其"独白"的特色鲜明;作为一种戏剧实践,它兼具先锋性与本土化的特征;作为一场戏剧运动,该戏取得的反响强烈、持久。%"The Vagina Monologues" is not only a feminist vanguard drama,but also set off a feminist movement.It has a distinctive characteristic of monologue as a drama itself and both vanguard and local features as a drama practice.It is also a peculiar drama movement gaining wide resonance and is of great enlightenment value.

  6. 广泛性子宫颈切除术加腹膜代阴道延长术治疗早期宫颈癌的临床研究%The clinical study of radical trachelectomy and vagina replacement by peritoneum in the treatment of early stage cervical cancer

    闫珺; 张菊新; 刘广芝; 王朕华

    2011-01-01

    Objective To compare the clinical results of radical trachelectomy and radical hysterectomy in treating patients with early stage cervical cancer and to evaluate the feasibility and security of radical trachelectomy and the sexual quality after vagina replacement by peritoneum. Methods Twenty-four women with early stage cervical cancer( IA2-IB1 ) were performed laparoscopic pelvic lymphadenectomy + radical trachelectomy + vagina replacement by peritoneum, and 32 women with early stage cervical cancer as control were performed laparoscopic pelvic lymphadenectomy + radical hysterectomy + vagina replacement by peritoneum. The operating time, blood lost, complications, recovery post surgery,recurrent rate and sexual quality were compared. For patients who received radical trachelectomy, the menstrual situation and pregnancy outcome post surgery were observed. Results All procedures were performed successfully. There was no significant difference between the two groups in the operating time, blood lost, complications, lymph node number or recovery post surgery ( P > 0. 05 ). Normal menstruation was recovered post surgery in all patients with radical trachelectomy. Pregnant rate was 45.45 % (5/11), full term delivery rate(Caesarean section) was 9.09% (1/11), miscarriage rate was 18.18% (2/11) ,and premature delivery rate was 18.18% (2/11). The two groups were followed up for 10 months to 5 years. There was no recurrent case and all patients were satisfied with their sexual activities. Conclusions Radical trachelectomy and radical hysterectomy have the same treating results for early stage cervical cancer. To prolong the vagina with peritoneum during the procedures can improve the sexual quality. Radical trachelectomy and vagina replacement by peritoneum is a selective treating strategy for patients with early stage cervical cancer who desire to preserve fertility and physiological function.%目的 比较广泛性子宫颈切除术与广泛性子宫切除术治疗早

  7. Local expression of surfactant protein A in the vagina of the patients with RVVC before and after treatment%表面活性蛋白A在复发性外阴阴道假丝酵母菌病患者治疗前后阴道局部的表达

    杨兰英; 贾俊茹; 王素芬; 李凤文

    2013-01-01

    Objective To observe the change of surfactant protein A(SP-A) level from the local vagina of the patients with recurrent vulvovaginal candidiasis (RVVC), discuss the relationship of the development and lapsing between SP-A and RVVC and analyze the effect of He-Ne laser (He -Ne) irradiation as the maintenance therapy on vaginal SP-A. Methods After initial antifungal treatment in the acute phase and adopting the maintenance therapy with He-Ne laser treatment for two courses for RWC patients (observation group), the treatment effect were followed up and the SP-A level of vaginal secretion were determined with ELISA method. At the same time, SP-A of the vaginal secretion specimen from healthy women of child-bearing age were detected and taken as control group. Results SP-A was (7. 24 ± 0. 76) nmol/L in control group with (1. 95 ± 0. 72) nmol/L in the acute phase of RVVC. After initial treatment, SP-A reached (2.92 ± 0. 53) nmol/ L, which was elevated comparing with that of acute episode (P<0.05). SP-A was (3. 64 ± 0. 62) nmol/L after the first treatment course with He-Ne laser, which got significant elevation comparing with that before laser treatment (P<0.05). After the second treatment course with laser, SP-A was (4.27 ±0.56) nmol/L, which was elevated comparing with that of the first treatment course (P< 0.05). On re-examination sixth months after stopping treatment, there was no significant difference for (3. 91 ± 0. 35) nmol/L of SP-A from local vagina in the observation group comparing with that of the laser treatment group after the second treatment course, but it was lower than that of the control group (P<0.001). There was significant decrease in SP-A from each group at various stages of RWC process comparing with that of the control group (P<0.001). Conclusion SP-A exists in local vagina, and the reduction of SP-A may be related to the development of RWC. The local irradiation with He-Ne laser may elevate SP-A level in vagina, thus, it provides evidence

  8. 保妇康凝胶联合乳酸菌素阴道胶囊治疗妊娠合并外阴阴道假丝酵母菌病的临床观察%Clinical Observation of Baofukang Gel Combined with Lactobacillus Vagina Capsule in Treatment of Pregnancy and Vulvovaginal Candidiasis

    田慧敏; 黄彦霞; 宋志红; 苏淑敏

    2013-01-01

    Objective:To explore the clinical curative effect and the safety of Baofukang gel combined with lactobacillus vagina capsule in treatment of vulvovaginal candidiasis. Method:Two hundred and seventy-two cases of pregnant women with vulvovaginal candidiasis were selected and randomly divided into two groups. Group A were given Baofukang gel combined with lactobacillus vagina capsule,while Group B were given only Baofukang gel. After using the medicines,the curative effect,drug’s side effect and recurrence rate between the two groups were compared. Result:The effective rate was 89.92%in group A while it was 76.22%in Group B after treatment,the total effective rate in Group A was significantly higher than that in Group B(P<0.05);The recurrence rate in Group A was 5%,while it was 19%in Group B,the difference was significant(P<0.01). Conclusion:The curative effect of Baofukang gel combined with lactobacillus vagina capsule in the treatment of vulvovaginal candidiasis is definite;It has little side effect and low recurrence rate.%目的:观察保妇康凝胶联合乳酸菌素阴道胶囊治疗妊娠合并外阴阴道假丝酵母菌病的临床疗效和安全性。方法:选择外阴阴道假丝酵母菌病的孕妇272例,随机分成两组。其中A组为保妇康凝胶联用乳酸菌素阴道胶囊组,用保妇康凝胶联合乳酸菌素阴道胶囊治疗, B组为保妇康凝胶组,单一应用保妇康凝胶治疗。用药后观察并比较两组治疗疗效、药物副作用及复发率情况。结果:治疗结束后,A组有效率89.92%,B组为76.22%,A组的总有效率明显高于B组,两组比较差异有统计学意义(P<0.05);复发率A组5%,B组19%,两者比较差异有统计学意义(P<0.01)。结论:保妇康凝胶联合乳酸菌素阴道胶囊治疗外阴阴道假丝酵母菌病疗效确切,副作用小,复发率低。

  9. Infectious characteristic analysis and drug-resistance of pathogens among vagina infection pregnancy with premature rup-ture of membranes%阴道病原菌感染与胎膜早破的关系及其耐药性分析

    楚丽娟; 罗婷婷; 杨桂林; 李秋红

    2014-01-01

    Objective The distribution characteristics and antibiotic resistance of specific pathogens among va-gina infection pregnancy with premature rupture of membranes (prom) ,in order to guide rational antibacterial thera-py .Methods During the periods of Jan ,2010 to Jul ,2012 ,pathogens from vagina with infectious pregnancy were gathered ,two groups-prom group and normal control were divided .The drug sensitivity of isolated strains were deter-mined by the broth dilution method .Results Only Streptococcus agalactiae (b group) and Staphylococcus aureus were found statistical significance between the two groups ,presenting higher detection in prom group(P<0 .05) .The resistant rates of Staphylococcus aureus to penicillin and ampicillin were 100% ,the sensitivity rates to erythrocin and azithromycin were 33 .3% and 50% ,respectively ,to tetracycline were 66 .7% ,others were all above of 83 .3% .The sensitivity rates of Streptococcus agalactiae (b group) to levofloxacin ,azithromycin ,erythrocin ,and ofloxacin were 30% ~40% ,yet above 80% of sensitivity to penicillin and cephems .Conclusion Streptococcus agalactiae (b group) and Staphylococcus aureus have an effect on prom .The drug sensitivity to the two bacteria are effected .Rational use of antibiotics and surveillance should be taken into account ,to avoid the development of drug-resistance strains .%目的:探讨影响孕妇胎膜早破的具体病原菌及其耐药情况,以合理地指导临床用药。方法随机选取2010年1月至2012年7月该院就诊的感染性胎膜早破的妊娠晚期女性为研究对象(患者组),未发生胎膜早破的孕妇作为对照(健康对照组),收集阴道分泌物病原菌,采用肉汤法进行药敏试验。结果患者组病原菌表现为无乳链球菌(b群)和金黄色葡萄球菌检出率高于健康对照组,差异有统计学意义( P<0.05)。金黄色葡萄球菌对氨苄西林和青霉素完全耐药,对红霉素和克

  10. Radiotherapeutic management of carcinomas of the vagina and vulva

    Purpose: To review important basic information regarding vaginal and vulvar carcinomas, including etiology, epidemiology, anatomy, pathology, spread patterns, presentation and work-up and staging. In addition, treatment concepts strategies, and radiotherapeutic techniques will be reviewed and discussed. Discussion: Vaginal carcinoma is rare, making up only 1-2% of gynecologic malignancies. However, the predominant role of radiotherapy (RT) is its management results in a significant number of patients referred to radiation oncology. Treatment and outcomes vary substantially according to stage. Important issues for consideration include the respective roles of external beam RT, brachytherapy, and surgery, intracavitary vs. interstitial brachytherapy, dose rate considerations, combined modality therapy, and management of non-squamous cell histologies. Vulvar carcinoma is similarly uncommon, comprising only 3-5% of gynecologic malignancies. Radiotherapy has a number of established roles in the management of this disease including adjuvant therapy, as part of combined modality treatment for advanced disease, salvage therapy, palliative treatment, and less often, as primary management. These issues will be discussed along with technical factors important in radiotherapeutic management. Finally, relevant literature will be reviewed with an emphasis of completed Gynecologic Oncology Group Trials

  11. Late effects of ionizing radiations on vulva, vagina and uterus

    Reporting and scoring complications after radiotherapy of gynaecological cancers is difficult because of the variety of treatment techniques involved. Use of an international classification is necessary to compare results obtained in series of patients treated in different institutions. An international group of experts designed in the early nineties the so-called French-Italian glossary. This classification of late effects is now completed with the new LENT SOMA scales. This paper contains details of these late changes, including their pathophysiology, clinical syndromes, potential treatment, and prevention. (authors)

  12. Biofilm formation among Candida albicans isolated from vagina

    2014-01-01

    Purpose: Study was conducted in a rural tertiary care hospital with a purpose to demonstrate the biofilm forming abilities of C. albicans isolated from cases of vulvovaginal candidiasis and asymptomatic carriers.Material and Methods: C. albicans was isolated and identified by standard laboratory techniques. Biofilm formation in vitro was tested using the 96 well microtitre plate method with crystal violet staining.Results: Overall rate of Candida isolation in study subjects was 40%. Candida i...

  13. Reconstruction of Acquired Defects of the Vagina and Perineum

    Salgado, Christopher J.; Chim, Harvey; Skowronski, Piotr P.; Oeltjen, John; Rodriguez, Meily; Mardini, Samir

    2011-01-01

    Successful reconstruction of vaginal and perineal defects requires close communication and cooperation between the extirpative and reconstructive surgeon. A variety of reconstructive options is available, dependent on the nature of the defect and extent of the ablative surgery. In all cases, obliteration of pelvic dead space and separation of intraabdominal contents from the perineum are important considerations to ensure uncomplicated perineal wound healing. The decision for vaginal reconstr...

  14. Pregnancy Complications: Bleeding and Spotting from the Vagina

    ... problem, but they can be a sign of miscarriage or other serious complications. Miscarriage is when a baby dies in the womb ... is a sign of a serious problem, like: Miscarriage . Almost all women who miscarry have bleeding or ...

  15. Primary invasive cancer of the vagina: outcome and complications of therapy

    The aim of the present study was to review the characteristics of cases of vaginal cancer, results of treatment and complications occurring at Westmead Hospital over the period 1979-96. International Federation of Gynaecology and Obstetrics (FIGO) staging and Eastern Cooperative Oncology Group (ECOG) status had been recorded prospectively, while other information was obtained retrospectively, including complications using the Franco-Italian Glossary. There were 37 eligible patients, 34 of whom were treated radically. Five-year survival for stage I was 90%, for stage 11 it was 50%, and for stage III it was 40%. There was only one stage-V patient. The majority of patients who relapsed did so locally (63%). Using the Franco-Italian Glossary 10.8% of patients had, at worst, G0 toxicity, 21.6% had G1 toxicity, 29.7% had G2 toxicity, 37.8% had G3 toxicity, and no patients had G4 toxicity. Seven patients (18.9%) had a laparotomy for a complication of therapy. Excluding the three palliative patients and controlling for disease stage, it was found that there was a trend to improved survival in patients who had brachytherapy and those who suffered worse complications. While results for treatment of early stage vaginal cancer appear good, new techniques, particularly those that improve local control, are required for higher stage disease. Copyright (1999) Blackwell Science Pty Ltd

  16. Primary T-Cell Non-Hodgkin Lymphoma of the Vagina

    Herraiz, J. L.; Llueca, A.; Maazouzi, Y.; Piquer, D.; A. Palmeiro; Calpe, E.

    2015-01-01

    The primary vaginal T-cell non-Hodgkin lymphoma is a rare form of lymphoma. Most of the previously published cases were about B-cell non-Hodgkin lymphomas. We present the case of a vaginal mass in an 82-year-old patient presenting vaginal bleeding. The results of the immunohistological studies of the mass revealed the presence of a cytotoxic T-cell non-Hodgkin lymphoma, which is the least common subtype.

  17. Laparoscopic management of fallopian tube prolapse masquerading as adenocarcinoma of the vagina in a hysterectomized woman

    Kucuk Mustafa

    2002-01-01

    Full Text Available Abstract Background Fallopian tube prolapse as a complication of abdominal hysterectomy is a rare occurrence. A case with fallopian tube prolapse was managed by a combined vaginal and laparoscopic approach and description of the operative technique is presented. Case presentation A 39-year-old woman with vaginal prolapse of the fallopian tube after total abdominal hysterectomy presented with an incorrect diagnosis of adenocarcinoma of the vaginal apex. The prolapsed tube and cystic ovary were removed by vaginal and laparoscopic approach. The postoperative course went well. Conclusions Early or late fallopian tube prolapse can occur after total abdominal hysterectomy and vaginal hysterectomy. Symptoms consist of persistent blood loss or leukorrhea, dyspareunia and chronic pelvic pain. Vaginal removal of prolapsed tube with laparoscopic surgery may be a suitable treatment. The abdominal or vaginal approach used in surgical correction of prolapsed tubes must be decided in each case according to the patient's individual characteristics.

  18. Radiotherapy for carcinoma of the vagina. Immunocytochemical and cytofluorometric analysis of prognostic factors

    Blecharz, P. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Gynecological Oncology; Reinfuss, M.; Jakubowicz, J. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Radiation Oncology; Rys, J. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Tumor Pathology Oncology; Skotnicki, P.; Wysocki, W. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Oncological Surgery

    2013-05-15

    Background and purpose: The aim of this study was to assess the potential prognostic factors in patients with primary invasive vaginal carcinoma (PIVC) treated with radical irradiation. Patients and methods: The analysis was performed on 77 patients with PIVC treated between 1985 and 2005 in the Maria Sklodowska-Curie Memorial Institute of Oncology, Cancer Center in Krakow. A total of 36 patients (46.8 %) survived 5 years with no evidence of disease (NED). The following groups of factors were assessed for potential prognostic value: population-based (age), clinical (Karnofsky Performance Score [KPS], hemoglobin level, primary location of the vaginal lesion, macroscopic type, length of the involved vaginal wall, FIGO stage), microscopic (microscopic type, grade, mitotic index, presence of atypical mitoses, lymphatic vessels invasion, lymphocytes/plasmocytes infiltration, focal necrosis, VAIN-3), immunohistochemical (protein p53 expression, MIB-1 index), cytofluorometric (ploidity, index DI, S-phase fraction, proliferation index SG2M) factors. Results: Significantly better 5-year NED was observed in patients: < 60 years, KPS {<=} 80, FIGO stage I and II, grade G1-2, MIB-1 index < 70, S-phase fraction < 10, and proliferation index < 25. Independent factors for better prognosis in the multivariate Cox analysis were age < 60 years, FIGO stage I or II, and MIB-1 index < 70. Conclusion: Independent prognostic factors in the radically irradiated PIVC patients were as follows: age, FIGO stage, MIB-1 index. (orig.)

  19. First report of transvaginal endoscopic microsurgery in a patient with squamous cell carcinoma of the vagina

    Smink, M.; Hermans, R.H.; Schoot, D.B.; Luyer, M.; Pijnenborg, J.M.A.

    2013-01-01

    Transanal endoscopic microsurgery has been used by surgeons since 1983. All these years of experience and research have shown that this is a safe and successful approach for rectal neoplasms, both benign and malignant. The advantage of this procedure is the excellent view and hence precise surgical

  20. Uterine perforation with bowel prolapsing through vagina following an unsafe abortion

    Kamala Verma; Girish Chandra Baniya

    2016-01-01

    An unwanted pregnancy may lead to induced abortion that means willful termination of pregnancy before the period of viability. Most of the times when termination of pregnancy is done by skilled person in fully aseptic environment, complications are low. But severe complication including uterine perforation, bowel injury, sepsis and sometimes death is common when the procedure is carried out by unskilled personnel in unhealthy condition. This case representing the neglected scenario of our mat...

  1. Uterus didelphys with an obstructed unilateral vagina and ipsilateral renal agenesis: A rare cause of dysmenorrhoea

    ATTAR, Rukset; Yıldırım, Gazi; Inan, Yücel; Küzılkale, Özge; Karateke, Ateş

    2013-01-01

    Didelphic uterus with obstructed hemivagina and ipsilateral renal agenesis is a rare condition. It usually presents with pelvic pain following the menarche, dysmenorrhoea, and an increase in abdominal volume or a palpable mass due to unilateral haematocolpos. We present the case of a 13-year-old girl who referred with recurrent pelvic pain, mainly at the time of menses, and irregular menstrual cycle complaints in this report. The patient underwent ultrasonography and magnetic resonance (MR) i...

  2. Clinical Holistic Medicine: Holistic Sexology and Acupressure Through the Vagina (Hippocratic Pelvic Massage)

    Søren Ventegodt; Birgitte Clausen; Hatim A. Omar; Joav Merrick

    2006-01-01

    Many gynecological and sexological problems (like urine incontinence, chronic pelvic pains, vulvodynia, and lack of lust, excitement, and orgasm) are resistant to standard medical treatment. In our work at the Research Clinic for Holistic Medicine in Copenhagen, we have found that vaginal acupressure, or Hippocratic pelvic massage, can help some of these problems. Technically, it is a very simple procedure as it corresponds to the explorative phase of the standard pelvic examination, suppleme...

  3. Fine structure of the male reproductive ducts, vagina and seminal receptacle of Cyathocephalus truncatus (Cestoda: Spathebothriidea)

    Poddubnaya, L. G.; Mackiewicz, J. S.; Bruňanská, Magdaléna; dezfuli, B. S.

    2005-01-01

    Roč. 52, č. 3 (2005), s. 241-250. ISSN 0015-5683 R&D Projects: GA ČR GA206/03/1317 Grant ostatní: Russian Foundation of Fundamental Research(RU) 05-0448250 Institutional research plan: CEZ:AV0Z60220518 Keywords : ultrastructure * reproductive organs * Cestoda Subject RIV: EA - Cell Biology Impact factor: 1.138, year: 2005

  4. Sheila Jeffreys: The Industrial Vagina. The Political Economy of the Global Sex Trade. London: Routledge 2008.

    Susanne Hofmann

    2010-03-01

    Full Text Available Sheila Jeffreys analysiert die Prozesse, die zu einer Industrialisierung und Globalisierung von Prostitution im späten 20. und 21. Jahrhundert geführt haben. Hauptverantwortlich für die gegenwärtige Diskursverschiebung um Prostitution ist für Jeffreys zum einen die sexuelle Revolution der 1970er Jahre und zum anderen die massive Finanzierung von Unterstützer/-innen der Sexarbeiterinnen zur HIV-Prävention in den 1980ern. Jeffreys legt wie in früheren Arbeiten ihre radikal-feministische Position dar und fordert eine Abschaffung der Prostitution. In ihrer Abrechnung mit dem liberalen feministischen Diskurs, für den eine Unterstützung von Sexarbeiterinnen prioritär ist, ignoriert sie die Widersprüchlichkeiten und Komplexitäten der gelebten Realitäten. An vielen Stellen ihres Buches bekräftigt Jeffreys stereotypische Männlichkeitsvorstellungen, was durch einen Blick über den Tellerrand des ihr vertrauten wissenschaftlichen Bezugsrahmens hätte vermieden werden können.Sheila Jeffreys analyzes the processes that led to the industrialization and globalization of prostitution in the late 20th and 21th centuries. Jeffreys considers those primary factors responsible for the current shift in discourse on prostitution, which can be attributed to the sexual revolution of the 1970s on the one hand, and to massive financing of HIV prevention in the 1980s by sex worker supporters on the other. As in earlier studies, Jeffreys presents readers with her radical-feminist position and demands prostitution be abolished. In her confrontation with liberal-feminist discourse, in which the support of sex workers takes priority, she ignores the inconsistencies and complexities of real lived experience. At many points throughout her book, Jeffreys affirms stereotypical male conceptions, which could have been avoided had she looked beyond the theoretical frame of reference that makes up her comfort zone.

  5. Uterus didelphys with an obstructed unilateral vagina and ipsilateral renal agenesis: A rare cause of dysmenorrhoea.

    Attar, Rukset; Yıldırım, Gazi; Inan, Yücel; Küzılkale, Ozge; Karateke, Ateş

    2013-01-01

    Didelphic uterus with obstructed hemivagina and ipsilateral renal agenesis is a rare condition. It usually presents with pelvic pain following the menarche, dysmenorrhoea, and an increase in abdominal volume or a palpable mass due to unilateral haematocolpos. We present the case of a 13-year-old girl who referred with recurrent pelvic pain, mainly at the time of menses, and irregular menstrual cycle complaints in this report. The patient underwent ultrasonography and magnetic resonance (MR) imaging of the pelvis was performed. The diagnosis was uterus didelphys with obstructed hemivagina and ipsilateral renal agenesia. Laparotomy was performed for diagnosis and treatment purposes. Two separated hemiuteri and two cervices with hematometra and hematocolpos on the right side and ipsilateral renal agenesis were detected. The vaginal septum was excised completely and Strassman metroplasty was performed. Her complaints were resolved and she was absolutely asymptomatic after surgery. Diagnosis and management of this congenital anomaly is challenging due to the complexity of the anatomic structures, nonspecific complaints, and heterogenic presentation. These anomalies must always be considered while working-up female patients presenting with episodic abdominal pain and abdominopelvic mass. PMID:24592115

  6. Sodium Tetradecyl Sulphate Direct Intralesional Sclerotherapy of Venous Malformations of the Vulva and Vagina: Report of Five Cases

    We report five cases of female patients affected by symptomatic focal external genital venous malformations treated with percutaneous direct intralesional injection of sodium tetradecyl sulphate (STS). All patients were referred because of discomfort and pain when sexual intercourse was attempted. Direct sclerotherapy with 3% STS was performed on a day-hospital basis with the patient under local anesthesia. Complete resolution of the symptoms was achieved in all cases. No major adverse effects were reported. Direct intralesional sclerotherapy with STS may be considered a safe and effective method for the treatment of female external genital malformation without the necessity of general anesthesia for pain control.

  7. Surgical instrument migration from the abdominal cavity through the bladder into the vagina: a rare long-term complication.

    Gier, R.P.E. de; Feitz, W.F.J.

    2002-01-01

    A foreign body in the bladder is a well-recognized, although rare, cause of urinary tract infections. We describe a 15-year-old girl who presented with abdominal pain and recurrent urinary tract infections. On analysis, a forceps was found, with the two legs of the instrument separately perforating

  8. Pelvic Organ Prolapse in Fibulin-5 Knockout Mice : Pregnancy-Induced Changes in Elastic Fiber Homeostasis in Mouse Vagina

    Peter G. Drewes; Yanagisawa, Hiromi; Starcher, Barry; Hornstra, Ian; Csiszar, Katalin; Marinis, Spyridon I.; Keller, Patrick; Word, R. Ann

    2007-01-01

    Pelvic organ prolapse is strongly associated with a history of vaginal delivery. The mechanisms by which pregnancy and parturition lead to failure of pelvic organ support, however, are not known. Recently, it was reported that mice with null mutations in lysyl oxidase-like 1 (LOXL1) develop pelvic organ prolapse. Elastin is a substrate for lysyl oxidase (LOX) and LOXL1, and LOXL1 interacts with fibulin-5 (FBLN5). Therefore, to clarify the potential role of elastic fiber assembly in the pathog...

  9. From toothpick legs to dropping vaginas: Gender and sexuality in Joan Rivers' stand-up comedy performance

    Lockyer, S.

    2011-01-01

    This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 Intellect. This article employs sociocultural analysis to examine Joan Rivers’ stand-up comedy performances in order to reveal how she successfully operates in a sphere of artistic expression that has been, and continues to be, male-dominated. The analysis uncovers how Rivers’ stand-up comedy performance involves a complex combination of elements and how it fuses feature...

  10. Late effects of ionizing radiations on vulva, vagina and uterus; Effets tardifs des radiations ionisantes sur la vulve, le vagin et l`uterus

    Mazeron, J.J. [Groupe Hospitalier Pitie-Salpetriere, 75 - Paris (France); Gerbaulet, A. [Institut Gustave Roussy, 94 - Villejuif (France)

    1997-12-01

    Reporting and scoring complications after radiotherapy of gynaecological cancers is difficult because of the variety of treatment techniques involved. Use of an international classification is necessary to compare results obtained in series of patients treated in different institutions. An international group of experts designed in the early nineties the so-called French-Italian glossary. This classification of late effects is now completed with the new LENT SOMA scales. This paper contains details of these late changes, including their pathophysiology, clinical syndromes, potential treatment, and prevention. (authors)

  11. SU-E-T-579: Impact of Cylinder Size in High-Dose Rate Brachytherapy (HDRBT) for Primary Cancer in the Vagina

    Zhang, H; Gopalakrishnan, M; Lee, P; Sathiaseelan, V [Department of Radiation Oncology, Northwestern Memorial Hospital, Chicago, IL (United States)

    2014-06-01

    Purpose: To evaluate the dosimetric impact of cylinder size in high dose rate Brachytherapy for primary vaginal cancers. Methods: Patients treated with HDR vaginal vault radiation in a list of cylinders ranging from 2.5 to 4 cm in diameter at 0.5 cm increment were analyzed. All patients’ doses were prescribed at the 0.5 cm from the vaginal surface with different treatment lengths. A series of reference points were created to optimize the dose distribution. The fraction dose was 5.5 Gy, the treatment was repeated for 4 times in two weeks. A cylinder volume was contoured in each case according to the prescribed treatment length, and then expanded to 5 mm to get a volume Cylinder-5mm-exp. A volume of PTV-Eval was obtained by subtracting the cylinder volume from the Cylinder-5mm-exp. The shell volume, PTV-Eval serves as the target volume for dosimetric evaluation. Results: DVH curves and average doses of PTV-Eval were obtained. Our results indicated that the DVH curves shifted toward higher dose side when larger cylinder was used instead of smaller ones. When 3.0 cm cylinder was used instead of 2.5 cm, for 3.0 cm treatment length, the average dose only increased 1%, from 790 to 799 cGy. However, the average doses for 3.5 and 4 cm cylinders respectively are 932 and 1137 cGy at the same treatment length. For 5.0 cm treatment length, the average dose is 741 cGy for 2.5 cm cylinder, and 859 cGy for 3 cm cylinder. Conclusion: Our data analysis suggests that for the vaginal intracavitary HDRBT, the average dose is at least 35% larger than the prescribed dose in the studied cases; the size of the cylinder will impact the dose delivered to the target volume. The cylinder with bigger diameter tends to deliver larger average dose to the PTV-Eval.

  12. Treatment of patients with a congenital transversal vaginal septum or a partial aplasia of the vagina. The vaginal pull-through versus the push-through technique.

    Bijsterveldt, C.D. van; Willemsen, W.N.P.

    2009-01-01

    STUDY OBJECTIVE: The aim of this study is to describe the different modalities of congenital obstructing vaginal malformations and the evaluation of techniques to solve the problem. DESIGN: A retrospective study. SETTING: The University Hospital Nijmegen, the Netherlands. PARTICIPANTS: The medical r

  13. Squamous cell carcinoma of the penis and of the cervix, vulva and vagina in spouses: is there any relationship? An epidemiological study from Norway, 1960-92.

    T. Iversen; Tretli, S.; A. Johansen; Holte, T.

    1997-01-01

    Four hundred and twenty-three wives of 671 men with cancer of the penis were compared with 444 wives of 569 men who did not have this disease. The risk among the wives of patients with cancer of the penis of preinvasive and invasive cancer of the neck of the uterus was 1.75 (95% CI 0.42-7.37).

  14. Nonoxynol-9 berberine plural gel has little effect on expression of SLPI, SP-D and lactoferrin in mice’s vagina

    Huang Guangying; Chen Suhua; Lu Fuer; Ma Yonggui; Qiao Yuan; Chen Zhuo

    2013-01-01

    Background: The most frequently used spermicide Nonoxynol-9 (N-9) in the clinic alters the vaginal flora, which will result in an increased risk of opportunistic infection. So development of a novel spermicidal and microbicidal drug appears to be inevitable. Vaginal local immune is an important part of vaginal flora. Secretory leukocyte protease inhibitor (SLPI), surfactant proteins D (SP-D), and lactoferrin (LF) are anti-microbial molecules with important roles in immune system of female vag...

  15. SU-E-T-579: Impact of Cylinder Size in High-Dose Rate Brachytherapy (HDRBT) for Primary Cancer in the Vagina

    Purpose: To evaluate the dosimetric impact of cylinder size in high dose rate Brachytherapy for primary vaginal cancers. Methods: Patients treated with HDR vaginal vault radiation in a list of cylinders ranging from 2.5 to 4 cm in diameter at 0.5 cm increment were analyzed. All patients’ doses were prescribed at the 0.5 cm from the vaginal surface with different treatment lengths. A series of reference points were created to optimize the dose distribution. The fraction dose was 5.5 Gy, the treatment was repeated for 4 times in two weeks. A cylinder volume was contoured in each case according to the prescribed treatment length, and then expanded to 5 mm to get a volume Cylinder-5mm-exp. A volume of PTV-Eval was obtained by subtracting the cylinder volume from the Cylinder-5mm-exp. The shell volume, PTV-Eval serves as the target volume for dosimetric evaluation. Results: DVH curves and average doses of PTV-Eval were obtained. Our results indicated that the DVH curves shifted toward higher dose side when larger cylinder was used instead of smaller ones. When 3.0 cm cylinder was used instead of 2.5 cm, for 3.0 cm treatment length, the average dose only increased 1%, from 790 to 799 cGy. However, the average doses for 3.5 and 4 cm cylinders respectively are 932 and 1137 cGy at the same treatment length. For 5.0 cm treatment length, the average dose is 741 cGy for 2.5 cm cylinder, and 859 cGy for 3 cm cylinder. Conclusion: Our data analysis suggests that for the vaginal intracavitary HDRBT, the average dose is at least 35% larger than the prescribed dose in the studied cases; the size of the cylinder will impact the dose delivered to the target volume. The cylinder with bigger diameter tends to deliver larger average dose to the PTV-Eval

  16. 外阴阴道假丝酵母菌性阴道病阴道局部固有免疫机制研究%Study on inherent immunity in vagina infected with vulvovaginal candidiasis

    彭丹红; 任慕兰

    2009-01-01

    目的 探讨外阴阴道假丝酵母菌性阴道病(VVC)阴道局部固有免疫机制.方法 选取2006年1月至2008年3月健康体检妇女、单纯性VVC患者和复发性VVC(RVVC)患者各20例,采集阴道灌洗液,行HE染色,细胞计数及分类,采用RT-PCR法测定阴道脱落细胞中单核细胞趋化蛋白-1(MCP-1)的mRNA水平.结果 (1)VVC组和RVVC组灌洗液的pH值分别为5.035±0.63和5.430±0.66,与对照组4.572±0.27比较,差异有统计学意义(P<0.05).(2)细胞分类中,VVC组中性粒细胞[(46.45±7.61)%]与对照组和RVVC组[分别为(18.25±3.27)%和(17.7±4.30)%]比较,差异有统计学意义(P<0.01);VVC组单核细胞(5.40±2.30)%,较对照组(3.90±1.68)%和RVVC组(3.70±1.42)%明显上升,差异有统计学意义(P<0.01).(3)对照组、VVC组和RVVC组MCP-1的mRNA表达分别为0.6363±0.0300、0.8338±0.1100、0.5315±0.0600,VVC组MCP-1的mR-NA显著高于对照人群,而RVVC组MCP-1的mRNA显著低于对照人群.结论 (1)阴道pH的改变与阴道的感染相关.(2)假丝酵母菌侵入机体后将导致机体的免疫防御反应,中性粒细胞和单核细胞数量增加并到达炎症部位发挥杀灭病原菌的作用.(3)阴道局部MCP-1低表达相关的免疫防御缺陷可能是RVVC反复发作的机制之一.

  17. 扩张阴道联合改良会阴保护法在接产中的临床应用%Expansion the vagina joint improvement perineum protection of clinical applications in the confinements

    易翠兰

    2013-01-01

      目的探讨扩张阴道联合改良会阴保护法在接产中的应用效果。方法选择2012年1月~12月在我科分娩的300例初产妇,随机分为观察组168例和对照组132例。观察组在接产过程中采用扩张阴道联合改良会阴保护法保护会阴;对照组采用传统式保护会阴法。并比较两组会阴裂伤及产后出血情况。结果观察组会阴裂伤88例,占52.38%,对照组会阴裂伤101例,占76.52%,两组比较有显著性差异(P<0.01);两组会阴裂伤程度、产后出血情况比较有显著性差异(P<0.01)。结论在接产过程中采用扩张阴道联合改良会阴保护法保护会阴,可降低会阴裂伤发生率,减轻会阴裂伤程度,保持会阴完整性,,以减轻产妇的痛苦。同时也减少产后出血的发生。%Objective In the production process through vaginal dilation and improved protection of perineum protection of perineum ,in order to reduce perineal laceration and side of the cutting rate ,reduce maternal pain ,and to observe its effect .Methods 300 cases of our hospital in 2012 were the single fetal head position of women in the 1-12 months ,weeks of gestation 37 ~ 41 weeks ,age 19-35 years old ,vaginal ,no lateral episiotomy indications of maternal .Were randomly di-vided into the observation group and 168 cases of vaginal dilation ,through improved protection of perineum protection of perineum inproduction process ;132 cases in the control group ,the traditional protection of perineum .Results in the obser-vation group ,88 cases of perineal laceration accounted for 52 .38% ,control group ,101 cases of perineal laceration accounted for 76 .52% ,the difference was statistically significant (P<0 .01);the two group of perineal laceration degree ,postpartum hemorrhage compared the differences were statistically significant (P<0 .01) .Conclusion In the production process through vaginal dilation and improved protection of perineum protection of perineum ,can reduce the incidence rate of perineal lacera-tion ,alleviate perineal laceration of perineum ,maintain integrity ,to reduce maternal pain .At the same time ,reduce the inci-dence of postpartum hemorrhage .

  18. Characterization of cytological changes, IgA, IgG and IL-8 levels and pH value in the vagina of prepubertal and sexually mature Ellegaard Göttingen minipigs during an estrous cycle

    Lorenzen, Emma; Agerholm, Jørgen Steen; Grossi, Anette Blak;

    2016-01-01

    The pig is increasingly used as an advanced animal model of the genital tract in women and knowledge on the genital immune system is therefore needed.In this study, evaluation of vaginal smears revealed that almost no neutrophils or other leukocytes were present in the vaginal mucosa of prepubert...

  19. Perioperative Nursing for Elderly Patients with Severe Pelvic Organ Prolapse Treated with Vagina Closure Surgery%重度盆腔器官脱垂患者行阴道封闭术的围术期护理

    冯莹; 张燕; 陈丽

    2010-01-01

    @@ 盆腔器官脱垂(pelvic organ prolapse,POP)是中老年妇女的常见病,发病率约为40%[1].POP患者,特别是POP-QⅢ期(依据国际尿控协会制定的盆腔器官脱垂定量分度法[2])及以上者,常合并有排尿和排便困难、尿失禁及粪失禁等症状,严重影响其日常生活.

  20. Characterization of cytological changes, IgA, IgG and IL-8 levels and pH value in the vagina of prepubertal and sexually mature Ellegaard Göttingen minipigs during an estrous cycle.

    Lorenzen, Emma; Agerholm, Jørgen Steen; Grossi, Anette Blak; Bojesen, Anders Miki; Skytte, Christina; Erneholm, Karin; Follmann, Frank; Jungersen, Gregers

    2016-06-01

    The pig is increasingly used as an advanced animal model of the genital tract in women and knowledge on the genital immune system is therefore needed. In this study, evaluation of vaginal smears revealed that almost no neutrophils or other leukocytes were present in the vaginal mucosa of prepubertal minipigs (n = 10). In sexually mature minipigs (n = 10), evaluated through an estrous cycle, there was an increase in number of mucosal neutrophils and other leukocytes during estrus. The level of total IgA on the vaginal mucosa increased during diestrus. The level of total IgG showed no significant changes through the cycle. The vaginal IgA level in the prepubertal minipigs was similar to the low estrus level in sexually mature minipigs, and the IgG level in prepubertal was similar to the stable level in the sexually mature minipigs. PMID:26801101

  1. 温度敏感性壬苯醇醚阴道用缓释凝胶的制备与评价%Preparation of temperature-sensitive nonoxynol-9 sustained-release gel for vagina

    王成伟; 唐星; 王晓梅; 田晓琳; 李真

    2006-01-01

    目的:制备以聚丙烯酸类为基本材料的温度敏感性壬苯醇醚阴道用缓释凝胶,建立温度敏感性阴道用缓释凝胶剂的体内外评价方法.方法:采用均匀试验设计,考察了泊洛沙姆F127和F68对凝胶化温度及25℃时和37℃时的黏度变化的影响,筛选出优化组合;加入聚丙烯酸类材料制备凝胶,进行显微观察、释放度、灌流冲洗量、黏度与黏附力评价;大鼠阴道内给予优化处方与国外产品,测定阴道冲洗液中药物的质量浓度.结果:温度敏感性材料优化组合为:泊洛沙姆F127的质量分数为18.2%,泊洛沙姆F68的质量分数为8.8%,制备的凝胶在大鼠阴道滞留时间可达12 h以上,室温下有较好的流动性.结论:温度敏感性壬苯醇醚阴道用缓释凝胶具有良好的体外释放性能、温度敏感黏附性能及阴道内滞留性能.

  2. Preparation and in vitro drug release characterization of nonoxynol-9 sustained-release gel for vagina%壬苯醇醚阴道用缓释凝胶的研制

    王成伟; 唐星; 姚家荣

    2004-01-01

    目的制备壬苯醇醚阴道用缓释凝胶并优化其处方与工艺.方法采用正交试验设计,考察了聚卡波菲用量、卡波沫用量、pH值、甘油用量、液体石蜡用量、山嵛酸甘油酯用量及不同工艺对释放度的影响,与国外产品进行残差平方和、拟合度、区分因子和相似因子比较,确定壬苯醇醚阴道用缓释凝胶的处方工艺,并考察了其初步稳定性.结果优化所得处方工艺为:聚卡波菲用量0.5%(w),卡波沫用量1%(w),甘油用量为5%(w),液体石蜡用量为5%(w),山嵛酸甘油酯用量为1%(w),pH值为4.5,选用工艺1.结论按优化处方工艺制得的壬苯醇醚阴道用缓释凝胶稳定,与国外产品比较具有相似的释放度,且以复合模式释放.

  3. 自慰、阴道-阴茎性行为、无性生活与快乐模型%Pleasure model of self-consolation,vagina -penis sexual behavior and celibacy

    田聚群

    2014-01-01

    According to the properties of skeletal muscle,frequency of sexual behavior can be divided into 4 types:injury frequency,dependence frequency,free frequency and zero frequency.To analyze from the perspec-tive of sexual desire disappearance,persons of dependence frequency,free frequency and zero frequency have the same living conditions.The person that has sexual intercourse and no sexual intercourse is of the same living condi-tions.Analyzing from the perspective of skeletal muscle dependence and pleasure model,self-consolation and va-gina-penis sexual behavior are in parallel relation.%根据骨骼肌的性质,性行为频率可以划分为4种类型:损伤频率;依赖频率;自由频率;零频率。从产生的性行为渴望完全消失的角度分析,选择依赖频率、自由频率和零频率的人拥有同样的生存状态,选择有性生活和无性生活的人拥有同样的生存状态。从骨骼肌依赖性质和快乐模型的角度分析,自慰和阴道-阴茎性行为是并列关系。

  4. Healthy Sexuality

    Full Text Available ... from the walls of the vagina. The vaginal muscles relax, causing the vagina to lengthen and widen. ... causing it to rise and stiffen. The smooth muscles of the scrotum contract, the skin of the ...

  5. What Is Vaginal Cancer?

    ... of the uterus) to open up at the vulva (the external female genitals). The vagina is lined ... cancer. Likewise, if the cancer involves both the vulva and the vagina, it’s considered a vulvar cancer. ...

  6. Medications for Pain Relief during Labor and Delivery

    ... that carry feeling to the vagina , vulva , and perineum . The drugs are given just before delivery. They ... spine. Episiotomy: A surgical incision made into the perineum (the region between the vagina and the anus) ...

  7. Uterine prolapse

    ... include: Pressure or heaviness in the pelvis or vagina Problems with sexual intercourse Leaking urine or sudden ... cervix drops into the lower part of the vagina . Uterine prolapse is moderate when the cervix drops ...

  8. Condoms - male

    ... contained in a male's semen reach a woman's vagina, pregnancy may occur. Condoms work by preventing sperm ... coming in contact with the inside of the vagina. If condoms are used correctly every time intercourse ...

  9. Estradiol Topical

    ... a medication that is applied topically to the vagina. Estradiol is in a class of medications called ... swelling, redness, burning, irritation, or itching of the vagina vaginal discharge Some side effects can be serious. ...

  10. Terconazole Vaginal Cream, Vaginal Suppositories

    ... to treat fungal and yeast infections of the vagina.This medication is sometimes prescribed for other uses; ... a cream and suppository to insert into the vagina. It is usually used daily at bedtime for ...

  11. Butoconazole Vaginal Cream

    ... is used to treat yeast infections of the vagina.This medication is sometimes prescribed for other uses; ... comes as a cream to insert into the vagina. It is usually used daily at bedtime. Follow ...

  12. Nystatin

    ... to treat fungal infections of the skin, mouth, vagina, and intestinal tract. Fungal medicines will not work ... and vaginal cream to be inserted into the vagina; and in powder, ointment, and cream to be ...

  13. Urinary incontinence - tension-free vaginal tape

    ... small surgical cut (incision) is made inside your vagina. Two small cuts are made in your belly ... tape is passed through the cut inside the vagina. The tape is then positioned under your urethra. ...

  14. Clotrimazole

    ... is used to treat yeast infections of the vagina, mouth, and skin such as athlete's foot, jock ... and vaginal cream to be inserted into the vagina. Clotrimazole is usually used five times a day ...

  15. Bacterial vaginosis - aftercare

    ... BV) is a type of vaginal infection. The vagina normally contains both healthy bacteria and unhealthy bacteria. ... when you urinate Itching inside and outside the vagina You also may not have any symptoms.

  16. Condom

    ... work by keeping semen (the fluid that contains sperm) from entering the vagina. The male condom is ... off when he gets soft. If this happens, sperm could enter the vagina. Female Condom The female ...

  17. Vaginitis

    ... led to advances in knowledge about the normal microflora of the vagina, reproductive behavior of yeast, and ... association between certain lactobacilli species in the normal microflora in the vagina and protection from bacterial vaginosis ( ...

  18. Ethinyl Estradiol and Etonogestrel Vaginal Ring

    ... as a flexible ring to place in the vagina.It is usually placed in the vagina and left in place for 3 weeks. After ... the contraceptive ring a certain way inside your vagina. The ring will work no matter how it ...

  19. Comparative study vagina mould/ fletcher applicator in MRI guided pulsed rate brachytherapy in patients reached by an uterine cervix carcinoma; Etude comparative moule vaginal/applicateur de fletcher en curietherapie de debit pulse guide par IRM chez les patientes atteintes d'un cancer du col uterin

    Francois, G.; Dumas, I.; Mazeron, R.; Verezesan, O.; Monnier, L.; Vieillot, S.; Gensse, M.C.; Haie-Meder, C. [Institut Gustave-Roussy, 94 - Villejuif (France)

    2009-10-15

    This study began in february 2009 and included until today ten patients. twenty patients are planned. The analysis of preliminary results show a much higher tolerance for the vaginal cast device. The dosimetry data were the object of a preliminary study that seems demonstrate an equivalence of the both modalities, with differences concerning the doses to critical organs; The definitive result swill be presented with the data including the twenty planned patients. (N.C.)

  20. Onamot Kang zuo union bacillus lacticus live fungus preparation treatment retinitis simplex vulva vagina rayon saccharomycetes sickness curative effect analysis%咪康唑联合乳酸杆菌活菌制剂治疗单纯性外阴阴道假丝酵母菌病疗效分析

    李莉; 杨东霞

    2010-01-01

    目的:观察咪康唑,定君生联合用药治疗单纯性外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC)的疗效.方法:将门诊150名VVC患者随机分为二组(n=75)A组阴道上达克灵400mg三天评定疗效,B组阴道上达克灵400mg三天同时阴道上定君生十天评定疗效.结果:A、B两组10天后治愈率分别为67%、69%.B组治愈率略高于A组(P>0.05),一月后复发率A、B两组分别是16%、5.77%,差异显著(P<0.05).结论:咪康唑合并乳酸杆菌胶囊治疗能降低VVC复发率.

  1. SEMEN COLLECTION AND CONSERVATION OF BULLS SEMEN PODOL TYPE CATTLE

    Premzl, B.; Božić, P.; Viduč, D.; Dejanović, Dubravka; Geceg, I.

    1994-01-01

    Semen collection, artificial vagina, electro-ejaculation, freeze semen We tray to collection ejaculates from bulls Podol Type Cattle with artificial vagina. Fantoms for collecting were cows in heat from the same herd or from another herd. We were not successafuly. With electro-ejaculation we collected ejaculates from bulls Podol Type Cattle and freeze semen in our Institute or in field.

  2. Surgical Tutorial of a Robotic-Assisted Anterior Pelvic Exenteration

    Full Text Available ... United States to have recurrence of her cervical cancer in the anterior portion of the cervix and the anterior vagina and it invading into ... involving the posterior bladder, the vagina and the cervix completely ... negative for cancer. She was surgically cured with this procedure that ...

  3. Cervical occlusion in women with cervical insufficiency: protocol for a randomised, controlled trial with cerclage, with and without cervical occlusion

    Secher, Niels Jørgen; MaCormack, CD; Weber, Tom;

    2007-01-01

    , without the membranes being exposed to the vagina. 6. Tertiary cerclage: Short cervix, membranes exposed to the vagina. Observational study: Eligible women who refuse to be randomised will participate in an observational study. 7. Repeat/requested cervical occlusion. METHODS: The women will be randomised...

  4. Formation of a vesicovaginal fistula in a pig model

    Lindberg, Jennifer; Rickardsson, Emilie; Andersen, Margrethe;

    2015-01-01

    the bladder and the vagina was made, and the mucosa between them was sutured together with absorbable sutures. A durometer ureteral stent was introduced into the fistula, secured with sutures to the bladder wall, allowing for the formation of a persistent fistula tract. Six weeks postoperatively cysto...... be an effective and cheap way to create a fistula between the bladder and vagina....

  5. Initiation and progression of Müllerian duct derived malignancies

    P.H. van der Horst (Paul)

    2013-01-01

    textabstractThe female reproductive system consists of the internal and external genitalia. The external genitalia are formed by the vulva, which includes the clitoris, labia majora and minora, urethral orifice and vestibule of the vagina (lower part of the vagina). The internal genital system is lo

  6. HERLYN - WERNER - WUNDERLICH SYNDROME (HWW SYNDROME): A CASE REPORT

    Pallavi S.; Ganpat; Gaurav

    2015-01-01

    Congenital anomalies of the mullerian duct system can result in various urogenital anomalies and, Herlyn Werner Wunderlich syndrome (HWW syndrome) is one such rare anomaly . This syndrome is characterized by uterus didelphys with blind hemi vagina and ipsilateral renal agenesis . 1 it is also known as OHVIRA (Obstructed Hemi vagina with ...

  7. Apical blebs on sperm-storage tubule epithelial cell microvilli: their release and interaction with resident sperm in the turkey hen oviduct

    Technical Abstract: Located at the anterior end of the turkey hen vagina are numerous discrete tubular invaginations of the surface epithelium, collectively referred to as the sperm-storage tubules (SSTs). Following mating or artificial insemination, sperm ascend the vagina, enter the SSTs, and ove...

  8. Surgical Tutorial of a Robotic-Assisted Anterior Pelvic Exenteration

    Full Text Available ... to you by Intuitive Surgical. During the program, it’s easy for you to learn about the procedure. ... of the cervix and the anterior vagina and it invading into the posterior bladder. To make matters ...

  9. Sexual Problems

    Full Text Available ... may be due to many factors, including physical, psychological, medical conditions, or medications. Men with male orgasmic ... into the vagina or as deep pain. Both psychological and physical factors can contribute to the condition. ...

  10. Surgical Tutorial of a Robotic-Assisted Anterior Pelvic Exenteration

    Full Text Available ... for locally invasive cervical cancer. She did very well, had no evidence of her cancer, as I ... the vagina, the cervix and surrounding tissues as well last the uterus and both tubes and ovaries. ...

  11. Ovarian Cancer Stage II

    ... primary peritoneal cancer) shows cancer in the pelvic peritoneum. Also shown are the cervix and vagina. In ... peritoneal cancer, cancer is found in the pelvic peritoneum and has not spread there from another part ...

  12. Episiotomy - aftercare

    Perineal laceration - aftercare; Vaginal birth perineal tear - aftercare; Postpartum care - episiotomy - aftercare ... to widen the opening of the vagina. A perineal tear or laceration often forms on its own ...

  13. Genital warts

    ... genitals. They may be found on the penis , vulva , urethra, vagina , cervix , and around and in the ... HPV can cause cancer of the cervix and vulva. They are the main cause of cervical cancer. ...

  14. Lymphogranuloma venereum

    ... lymph nodes in the groin Swelling of the vulva or labia in women Swollen lymph nodes in ... Infections of the lower and upper genital tracts: vulva, vagina, cervix, toxic shock syndrome, endometritis, and salpingitis. ...

  15. Rectocele

    ... isolated finding or occur as part of a generalized weakening of the pelvic floor muscles. Other pelvic ... to defecate on a specially-designed commode after contrast material is instilled in the rectum, vagina and ...

  16. Surgical Tutorial of a Robotic-Assisted Anterior Pelvic Exenteration

    Full Text Available ... part of the vagina, the cervix and surrounding tissues as well last the uterus and both tubes ... sac. We see some radiation fibrosis, the mottled tissue from fibrosis. And that will become an issue ...

  17. Women and HIV

    ... on HIV testing. Gynecological problems can be early signs of HIV infection . Ulcers in the vagina, persistent yeast infections, and severe pelvic inflammatory disease (PID) can be signs of HIV. Hormone changes, birth control pills, or antibiotics can ...

  18. Sexual abuse in children - what to know

    Sexual abuse - children ... boys are sexually abused before they turn 18. Sexual abuse of children is any activity that the abuser ... anus or vagina Tongue kissing Oral sex Intercourse Sexual abuse can also happen without physical contact, such as: ...

  19. Sexual Problems

    Full Text Available ... pleasurable sexual sensations in her clitoris or vagina. Male erectile disorder, or ED, is the inability of ... physical, psychological, medical conditions, or medications. Men with male orgasmic disorder have a delay in, or absence ...

  20. Colposcopy

    ... in the stirrups as you would for a Pap smear. Your doctor inserts a speculum into your vagina ... your doctor find the reason for an abnormal Pap smear. Why is colposcopy important? A colposcopy is important ...

  1. Sexual Problems

    Full Text Available ... occur with entry into the vagina or as deep pain. Both psychological and physical factors can contribute ... All Rights Reserved. ASRM Non Discrimination Policy | ASRM Web Site Terms & Conditions of Use | Web Design and ...

  2. Biopsy - polyps

    Polyp biopsy ... are treated is the colon. How a polyp biopsy is done depends on the location: Colonoscopy or flexible sigmoidoscopy explores the large bowel Colposcopy-directed biopsy examines the vagina and cervix Esophagogastroduodenoscopy (EGD) or ...

  3. Surgical Tutorial of a Robotic-Assisted Anterior Pelvic Exenteration

    Full Text Available ... In this procedure, I remember us gathering about 42 lymph nodes in total. Yes. And urologists who ... the vagina and the cervix completely removed, all 42 lymph nodes were negative for cancer. She was ...

  4. Urine 24-hour volume

    ... test results: Dehydration Any type of x-ray exam with dye (contrast material) within 3 days before the urine test Fluid from the vagina that gets into the urine Emotional stress Heavy exercise Urinary tract infection

  5. 24-hour urine protein

    ... of fluid (dehydration) Any type of x-ray exam with dye (contrast material) within 3 days before the urine test Fluid from the vagina that gets into the urine Severe emotional stress Strenuous exercise Urinary tract infection

  6. Dyspareunia: Painful Sex for Women

    ... part of the genitals can cause pain during sex. Some conditions affect the skin around the vagina. ... types of birth control) does not fit correctly, sex may also be painful. Vaginismus (say: "vag-in- ...

  7. Ultrasound -- Pelvis

    Full Text Available ... and processes the sounds and creates graphs or color pictures that represent the flow of blood through ... into the vagina. The images are obtained from different orientations to get the best views of the ...

  8. Microflora of urogenital tract in pregnancy with asymptomatic bacterium

    The article contains results of research interrelationship from colonization of vagina and urinary tract diseases. E.coli one of the main factors in development asymptomatic bacterium. Presented high effects of penicillin medicaments and nitrofurans in treatment of asymptomatic bacterium

  9. General Ultrasound Imaging

    Full Text Available ... major branches liver gallbladder spleen pancreas kidneys bladder uterus , ovaries , and unborn child ( fetus ) in pregnant patients ... inserted into a woman's vagina to view the uterus and ovaries. top of page What will I ...

  10. Hysteroscopy

    ... the uterus . A hysteroscope is a thin, lighted telescope-like device. It is inserted through your vagina ... hysteroscope, bleeding may occur, or excess fluid may build up in your system. In rare cases, hysteroscopy ...