WorldWideScience
 
 
1

Vagina  

Science.gov (United States)

The vagina is the female body part that connects the womb (uterus) and cervix to the outside of the ... The vagina is a muscular tube lined with mucus membranes. Its opening is between the urethra (where urine exits ...

2

Irradiated vagina  

International Nuclear Information System (INIS)

The gross and microscopic changes following different modes of therapy for 97 cases of Stage I and II carcinoma of the cervix were studied. Features frequently present in the radiotherapy patients were: narrowing or obliteration of the vagina, pelvic fibrosis, pain or discomfort on pelvic examination, and gross and microscopic changes in the vagina typical of radiation fibrosis; in addition, the vaginal cytology was not altered after estrogen stimulation. These features were less frequent in the surgical patients. Of all the organs in the body, the vagina is exposed to the heaviest doses of irradiation. (U.S.)

1974-01-01

3

Leiomyoma of the vagina.  

Science.gov (United States)

A vaginal leiomyoma is normally a benign smooth muscle tumour in the vagina. These tumours are extremely rare and the aetiology is unknown. The imaging findings are those of a nonspecific well-defined enhancing soft tissue mass centred on the vagina. The lesion may be very large, but is usually under 6 cm in size. Patients are asymptomatic in the early stages. Symptoms arise with the growth of tumour mainly due to compression. Most leiomyomas are not diagnosed clinically but only on histological examination. A case of primary leiomyoma of vagina is presented here. PMID:14552254

Hameed, Nazli

2003-01-01

4

Air in vagina  

International Nuclear Information System (INIS)

Computed tomography of the normal female pelvis may show the presence of a tiny air bubble within the vagina. Among 2800 female abdomino-pelvic CTs, 27 were found to contain large amounts of intravaginal air. Twenty-three patients suffered from pelvic malignancy while in 4, non-tumorous pelvic pathology was present. Detection of air bubbles in the vagina is abnormal and indicates, in the majority of cases, an intrapelvic malignancy. (orig.)

1991-01-01

5

Melanomas of the Vagina.  

Science.gov (United States)

The clinical and pathologic findings in 13 patients with melanomas arising in the vagina are presented. Melanin pigment was present in 11 and junctional change was present in 10. Attention is drawn to the atypical microscopic appearance of some vaginal me...

H. J. Norris H. B. Taylor

1966-01-01

6

Leiomyosarcoma of the vagina.  

Science.gov (United States)

Vaginal leiomyoma is uncommon and borderline leiomyoma of the vagina is an extreme rarity. Leiomyoma of the vagina may undergo malignant change to become borderline malignancy or leiomyosarcoma. A 38-year-old woman, complaining of foul vaginal discharge and dyspareunia with 2 months duration, underwent total excision of tumor. The removed tumor was diagnosed as borderline case of leiomyoma histologically. Unfortunately, she had tumor recurrence within 4 months. Thus, it was more likely that the primary diagnosis was incorrect and that the diagnosis leiomyosarcoma has been missed. She underwent total abdominal hysterectomy, bilateral salphingo-oophorectomy and total vaginectomy. The final diagnosis was leiomyosarcoma. Three months later tumor recurred again and re-excision followed by chemotherapy was performed. However, she died of her disease on her 5th month following three courses of chemotherapy. PMID:9119105

Cobano?lu, O; Gürkan Zorlu, C; Ergun, Y; Kutluay, L

1996-12-27

7

Vagina evaluation by MR imaging  

International Nuclear Information System (INIS)

The author evaluated MR imaging of the vagina under different hormonal stimuli (25 patients) and assessed the role of MR imaging in the evaluation of congenital abnormalities (15 patients), primary (3) and metastatic (5) neoplasms, and reconstructive surgery (3). The findings were confirmed surgically. The appearance of the mucosa and vaginal wall was influenced by hormonal status. The presence of the vagina (45 patients), absence of the vagina (4), and the presence of duplication anomaly (3) were always accurately demonstrated on MR images. Carcinoma and metastases were depicted as tumor interrupting the low intensity signal of the muscular wall of the vagina. In two of three patients who underwent reconstructive surgery, postsurgical perivaginal abscesses developed that were correctly displayed on MR images. The normal and abnormal vaginas were exquisitely shown on MR images. For complicated congenital abnormalities, complications of postreconstructive surgery, and staging of neoplasms, MR imaging should be considered a primary imaging modality

1986-12-05

8

Brenner tumour of the vagina.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Polyps of the vagina are rare and are either of inflammatory/reactive or neoplastic origin. A case of extraovarian Brenner tumour of the vagina in a postmenopausal woman, who presented with a vaginal polyp, is described. The polyp was excised and on histological examination, had the triphasic pattern (transitional, glandular and stromal) characteristic of Brenner tumour. The histogenesis of Brenner tumour is discussed in the context of this unusual location and the controversy of its origin.

Rashid, A. M.; Fox, H.

1995-01-01

9

Antibiotic susceptibility of Atopobium vaginae  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Previous studies have indicated that a recently described anaerobic bacterium, Atopobium vaginae is associated with bacterial vaginosis (BV. Thus far the four isolates of this fastidious micro-organism were found to be highly resistant to metronidazole and susceptible for clindamycin, two antibiotics preferred for the treatment of BV. Methods Nine strains of Atopobium vaginae, four strains of Gardnerella vaginalis, two strains of Lactobacillus iners and one strain each of Bifidobacterium breve, B. longum, L. crispatus, L. gasseri and L. jensenii were tested against 15 antimicrobial agents using the Etest. Results All nine strains of A. vaginae were highly resistant to nalidixic acid and colistin while being inhibited by low concentrations of clindamycin (range: G. vaginalis strains were also susceptible for clindamycin ( 256 ?g/ml but susceptible to clindamycin (0.023 – 0.125 ?g/ml. Conclusion Clindamycin has higher activity against G. vaginalis and A. vaginae than metronidazole, but not all A. vaginae isolates are metronidazole resistant, as seemed to be a straightforward conclusion from previous studies on a more limited number of strains.

Verschraegen Gerda

2006-03-01

10

Intestinal prolapse through the vagina.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We describe the case of a 68-year-old woman who presented with an acute onset spontaneous vaginal vault rupture and intestinal prolapse through the vagina. Results of a literature survey are presented and the causes of vaginal vault rupture are discussed.

Patankar, R. V.; Scott, S. D.; Mcginn, F. P.

1993-01-01

11

Vesicouterine fistula and blind vagina  

International Nuclear Information System (INIS)

A case of vesicouterine fistula with blind vagina following cesarean section for obstructed labor is presented. It was surgically treated by fistulectomy, cervicoplasty and maintenance of bladder and cervical potency by catheterization. Intrauterine synechiae formation was prevented by copper T insertion and oral contraceptive pills. The patient is making uneventful a symptomatic progress planning to conceive. (author)

2003-04-01

12

Vagina invasion by cervical carcinoma.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Seventy patients with cervical carcinoma who underwent radical hysterectomy and pelvic lymphadenectomy were evaluated to assess spread to the vagina. The overall vaginal invasion rate was 34.2% (24/70), with 36% (21/58) by squamous cell carcinoma, 25% (2/8) by adenocarcinoma and 25% (1/4) by adenosquamous carcinoma. A high vaginal invasion rate (45.7%) was noted in cases in which the cervical lesion was greater than 21 mm (p less than 0.05). Combined parametrial extention (45%) and combine...

Chen, Neng-jing

1984-01-01

13

Pregnancy Complications: Bleeding and Spotting from the Vagina  

Science.gov (United States)

... Bleeding and spotting from the vagina during pregnancy Pregnancy complications Pregnancy complications may need special medical care. ... dashboard . Bleeding and spotting from the vagina during pregnancy Bleeding and spotting from the vagina during pregnancy ...

14

[Tethered vagina syndrome after classical anterior colporrhaphy].  

Science.gov (United States)

We presented etiology symptomatology and diagnosis of the tethered vagina syndrome. Detailed information concerning pharmacological and surgical treatment was given. Surgical method of vaginal anatomy restoration using Martius flap technique was described in patients with tethered vagina syndrome after classical anterior colporrhaphy. We paid special attention to a particular type of genital fibrosis such as labial fusion in girls. PMID:22379943

Monist, Marta; Kulik-Rechberger, Beata; Tomasz, Rechberger

2011-10-01

15

Reconstruction of Congenital Defects of the Vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Congenital absence of the vagina is a relatively rare condition most commonly associated with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. Historically, several reconstructive techniques have been described to provide for functional vaginal reconstruction on these patients, both operative and nonoperative. Although there are many advantages and disadvantages of the various procedures, one experience with the use of split thickness skin grafts to reconstruct the vagina has produced acceptab...

Eldor, Liron; Friedman, Jeffrey D.

2011-01-01

16

Endodermal sinus tumor of vagina in infants  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Endodermal sinus tumor (or Yolk Sac tumor) of the vagina is a rare malignant germ-cell tumor which is seen exclusively in children younger than 3 years of age. We report two cases of endodermal sinus tumor of the vagina. In both cases no radiological investigation was done and serum alpha-fetoprotein was elevated. The histopathological examination of both the tumor masses revealed vaginal endodermal sinus tumor. Periodic-acid-Schiff stain with diastase showed diastase resistant hyaline globul...

Smita Chauhan; Jitendra Singh Nigam; Pallavi Singh; Vatsala Misra; Brijesh Thakur

2013-01-01

17

Embryonal rhabdomyosarcoma of the vagina in children  

International Nuclear Information System (INIS)

Eight cases of childhood rhabdomyosarcoma arising in the vagina are presented. All were treated with curie therapy, and 7 of 8 received chemotherapy in addition. With a median follow up of 4 yr, 6 of 7 had local control without surgery, 1 required colpohysterectomy for microscopic disease after curie therapy. These techniques of curie therapy and chemotherapy for localized rhabdomyosarcoma of the vagina allow one to obtain the cure while avoiding mutilating surgery. (author)

1979-01-01

18

Brachytherapy for the malignant tumours of vagina  

International Nuclear Information System (INIS)

In 1986-1995 a total of 134 patients with malignant tumours of vagina were treated by interstitional radiotherapy. Fifty-two patients were irradiated with 60Co sources, and 82 patients - with 252Cf sources. Fourteen patients had primary carcinoma of vagina, 120 patients had metastases and recurrences in vagina. We used 60Co and 252Cf irradiation sources; their active length was 20-30 mm with an increasing activity at the ends. Special template devices made it possible to implant 2-16 sources in a strictly pre-set geometry. Radiation treatment was mainly interstitial therapy. Some patients underwent additional external radiotherapy (20-40 Gy), taking into account the time and dosage of previously applied therapy. Complete tumour regression was observed in 13 (92.8%) patients with primary vaginal carcinomas. In 1 patient more than 50% partial regression was observed. In 114 (85%) patients with tumour recurrences and metastases to the vagina complete tumour regression was observed. Partial regression was observed in 14 (10.4%), and there was no effect in 6 (4.4%) patients with tumour recurrences and metastases to the vagina. Five year survival was 46% for all treated patients. Mild radiation reactions were found in 35 (26.1%) patients. In 3 patients radiation ulcers developed in irradiation area. It should be noted that radiation reactions appeared later when radiation sources with 252Cf were used

1996-05-01

19

Imaging of the vagina and vulva  

International Nuclear Information System (INIS)

In gynecological daily practices, the vulva and vagina are examined during physical examination, however there are situations where this is not possible or it is needed to determine the extension of an injury through imaging methods. The magnetic resonance imaging is an excellent cross-sectional modality for evaluation the alterations of vulva and vagina due its multiplanar evaluation and high tecidual contrast. Other cross-sectional modalities are ultrasound and enhanced computed tomography. This paper intends to give an overview of vaginal and vulvar pathology that can be identified by the radiologist. (author)

2006-10-01

20

Reconstruction of congenital defects of the vagina.  

Science.gov (United States)

Congenital absence of the vagina is a relatively rare condition most commonly associated with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. Historically, several reconstructive techniques have been described to provide for functional vaginal reconstruction on these patients, both operative and nonoperative. Although there are many advantages and disadvantages of the various procedures, one experience with the use of split thickness skin grafts to reconstruct the vagina has produced acceptable functional results with limited donor site morbidity. Careful planning and timing of this form of reconstruction can produce predictable results in patients who are nearing sexual maturity. PMID:22547971

Eldor, Liron; Friedman, Jeffrey D

2011-05-01

 
 
 
 
21

Adenocarcinoma de células claras de la vagina  

Directory of Open Access Journals (Sweden)

Full Text Available Se presenta un caso clínico de adenocarcinoma de células claras de vagina en mujer de 23 años, sin antecedentes de exposición intrauterina a dietilestilbestrol. Se efectuó colpohisterectomía radical, linfadenectomía pélvica completa y ooforopexia bilateral, más radioterapia externa adyuvante (45 Gy. Sin evidencia de enfermedad a 5 meses de completada su terapiaA case of clear cell adenocarcinoma of the vagina in a 23 year old woman, without diethylstilbestrol intrauterine exposure, is presented. The surgical and the radiotherapy treatment are discussed. Without evidence of disease at 5 months follow up. A brief discussion of literature is also provided

Rubén Urrejola S.

2004-01-01

22

Infektionen an Vulva, Vagina und Zervix  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Selektive Literaturarbeit und Internetkompendium zu Infektionen an Vulva, Vagina und Zervix. 654 Fachartikel der vergangenen Dekade werden zitiert, 90 Abbildungen und Tabellen strukturieren die Flut an Daten. Es wird eine gute Übersicht über genitale Infektionen gegeben. Die wissenschaftlich fundierten Aussagen aus dem Grundlagenteil werden im Internetkompendium komprimiert auf einer Startseite zusammengefügt, in den tieferen Ebenen sind weiterführende Kommentare verlinkt. In einem diagno...

Buchberger, Andrea

2009-01-01

23

Primary leiomyosarcoma of vagina: case report  

International Nuclear Information System (INIS)

Primary malignant lesions of the vagina are uncommon and represent about 1% of all gynecological malignancies. Most of these neoplasms are carcinomas. Sarcomas comprise less than 2% of all malignant vaginal tumours. In this present article, we describe a primary vaginal leiomyosarcoma in a 40-years-old woman. (author)

2004-01-01

24

Endodermal sinus tumor of vagina in infants  

Directory of Open Access Journals (Sweden)

Full Text Available Endodermal sinus tumor (or Yolk Sac tumor of the vagina is a rare malignant germ-cell tumor which is seen exclusively in children younger than 3 years of age. We report two cases of endodermal sinus tumor of the vagina. In both cases no radiological investigation was done and serum alpha-fetoprotein was elevated. The histopathological examination of both the tumor masses revealed vaginal endodermal sinus tumor. Periodic-acid-Schiff stain with diastase showed diastase resistant hyaline globules. These findings confirmed the diagnosis of endodermal sinus tumor in both cases. Vaginal endodermal sinus tumor is both locally aggressive and capable of metastasis. The serum alpha-fetoprotein level is a useful marker for diagnosis and monitoring the recurrence of vaginal endodermal sinus tumor in infants. Early detection and therapy is important because of its aggressive nature and good response to chemotherapy.

Brijesh Thakur

2013-04-01

25

Cáncer primario de vagina Vaginal primary cancer  

Directory of Open Access Journals (Sweden)

Full Text Available El carcinoma primario de vagina es una neoplasia poco frecuente, representando solamente el 1-2 % de todos los tumores malignos del área ginecológica. Según la FIGO solo se considera como cáncer primario de vagina a aquellas lesiones confinadas a la vagina sin invasión del cuello uterino o la vulva. El pronóstico depende principalmente del estadio en que se encuentra la enfermedad, pero la supervivencia se reduce en pacientes mayores de 60 años de edad, si son sintomáticos al momento del diagnóstico, tienen lesiones del centro y tercio inferior de la vagina o tienen tumores mal diferenciados. Los objetivos de este estudio fueron evaluar la experiencia en el manejo del cáncer primario de vagina, identificar variables demográficas y clínicas, mostrar la variedad histológica de presentación de esta neoplasia tan rara, así como el grado de diferenciación en cada caso. Igualmente relacionar estadio del cáncer, tratamiento y respuesta en cada una de las pacientes. Se trata de un estudio retrospectivo de cinco pacientes con cáncer primario de vagina atendidas en el Servicio de Patología de cuello del Hospital Ramón González Coro, durante el año 2008. La evaluación inicial consistió en una historia clínica completa, examen físico haciendo hincapié en el área ginecológica descartando lesiones en vulva o cuello uterino. A todas las pacientes se les realizó biopsia excisional del tumor, enviando la muestra al estudio histopatológico. Se les realizó cistoscopia, rectoscopia, urograma descendente, a aquellas pacientes con sospecha de infiltración de vejiga o recto, laboratorio, radiografía del tórax y se estadiaron según la clasificación de la FIGO.The primary vaginal carcinoma is a uncommon neoplasm present only in the 1-2% of all the malignant tumors of gynecology area. According to International Federation of Gynecology and Obstetrics only is considered as a primary vaginal cancer of those lesions confined to vagina without invasion of cervix or the vulva. The prognosis depends mainly on the disease stage, but the survival is reduced in patients aged over 60 if they are symptomatic at diagnosis, have lesions of the center and the inferior third of vagina or have ill-differentiated. The objectives of present study were to assess the experience in the vaginal primary cancer management, to identify demographic and clinical variables, to show the histological variety of presentation of this so rare neoplasm, as well as the differentiation grade of each case and to relate the cancer stage, the treatment and the response of each patient. It is retrospective study conducted in 5 patients presenting vaginal primary cancer seen in the Cervix Pathology Service of the "Ramón González Coro" Gynecology and Obstetrics Hospital during 2008. The initial assessment included a complete medical record, physical examination with emphasis in the gynecological area ruling out vulva or cervix uteri lesions. All patients underwent excision biopsy of tumor with the corresponding histopathological study of the sample. A cystoscopy, rectoscopy descending urogram were carried out in those patients with a possible bladder or rectum infiltration, lab tests, thorax Rx staged according the International Federation of Gynecology and Obstetrics classification.

Raiza Ruiz Lorente

2010-09-01

26

Cáncer primario de vagina / Vaginal primary cancer  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish El carcinoma primario de vagina es una neoplasia poco frecuente, representando solamente el 1-2 % de todos los tumores malignos del área ginecológica. Según la FIGO solo se considera como cáncer primario de vagina a aquellas lesiones confinadas a la vagina sin invasión del cuello uterino o la vulva. [...] El pronóstico depende principalmente del estadio en que se encuentra la enfermedad, pero la supervivencia se reduce en pacientes mayores de 60 años de edad, si son sintomáticos al momento del diagnóstico, tienen lesiones del centro y tercio inferior de la vagina o tienen tumores mal diferenciados. Los objetivos de este estudio fueron evaluar la experiencia en el manejo del cáncer primario de vagina, identificar variables demográficas y clínicas, mostrar la variedad histológica de presentación de esta neoplasia tan rara, así como el grado de diferenciación en cada caso. Igualmente relacionar estadio del cáncer, tratamiento y respuesta en cada una de las pacientes. Se trata de un estudio retrospectivo de cinco pacientes con cáncer primario de vagina atendidas en el Servicio de Patología de cuello del Hospital Ramón González Coro, durante el año 2008. La evaluación inicial consistió en una historia clínica completa, examen físico haciendo hincapié en el área ginecológica descartando lesiones en vulva o cuello uterino. A todas las pacientes se les realizó biopsia excisional del tumor, enviando la muestra al estudio histopatológico. Se les realizó cistoscopia, rectoscopia, urograma descendente, a aquellas pacientes con sospecha de infiltración de vejiga o recto, laboratorio, radiografía del tórax y se estadiaron según la clasificación de la FIGO. Abstract in english The primary vaginal carcinoma is a uncommon neoplasm present only in the 1-2% of all the malignant tumors of gynecology area. According to International Federation of Gynecology and Obstetrics only is considered as a primary vaginal cancer of those lesions confined to vagina without invasion of cerv [...] ix or the vulva. The prognosis depends mainly on the disease stage, but the survival is reduced in patients aged over 60 if they are symptomatic at diagnosis, have lesions of the center and the inferior third of vagina or have ill-differentiated. The objectives of present study were to assess the experience in the vaginal primary cancer management, to identify demographic and clinical variables, to show the histological variety of presentation of this so rare neoplasm, as well as the differentiation grade of each case and to relate the cancer stage, the treatment and the response of each patient. It is retrospective study conducted in 5 patients presenting vaginal primary cancer seen in the Cervix Pathology Service of the "Ramón González Coro" Gynecology and Obstetrics Hospital during 2008. The initial assessment included a complete medical record, physical examination with emphasis in the gynecological area ruling out vulva or cervix uteri lesions. All patients underwent excision biopsy of tumor with the corresponding histopathological study of the sample. A cystoscopy, rectoscopy descending urogram were carried out in those patients with a possible bladder or rectum infiltration, lab tests, thorax Rx staged according the International Federation of Gynecology and Obstetrics classification.

Ruiz Lorente, Raiza; Hernández Durán, Daisy; Tamayo Lien, Tania Graciela; de la Torre, Ana Isabel.

27

Radiation treatment policy for carcinoma vagina  

International Nuclear Information System (INIS)

A small group of patients of primary carcinoma vagina is presented with their clinical profile and with an emphasis on external radiation therapy for such cases. Short-term control rate has been encouraging. It is recommended that an aggressive treatment policy even in locally advanced tumour and radical radiation with suitable branchytherapy practices can give as good results as with surgery with minimum of morbidity. Relevant literature has been reviewed. (auth.)

1979-05-01

28

Bacterial Vaginosis, Atopobium vaginae and Nifuratel  

Digital Repository Infrastructure Vision for European Research (DRIVER)

As bacterial vaginosis (BV) is a potential cause of obstetric complications and gynecological disorders, there is substantial interest in establishing the most effective treatment. Standard treatment - metronidazole or clindamycin, by either vaginal or oral route – is followed by relapses in about 30% of cases, within a month from treatment completion. This inability to prevent recurrences reflects our lack of knowledge on the origins of BV. Atopobium vaginae has been recently reported to b...

Polatti, Franco

2012-01-01

29

Primary leiomyosarcoma of vagina: case report; Leiomiossarcoma primario de vagina: relato de caso  

Energy Technology Data Exchange (ETDEWEB)

Primary malignant lesions of the vagina are uncommon and represent about 1% of all gynecological malignancies. Most of these neoplasms are carcinomas. Sarcomas comprise less than 2% of all malignant vaginal tumours. In this present article, we describe a primary vaginal leiomyosarcoma in a 40-years-old woman. (author)

Vieira, Leonardo Jose [Hospital ASCONCER Associacao Feminina de Prevencao e Combate ao Cancer, Juiz de Fora, MG (Brazil). Servico de Cirurgia; Freitas, Rosyane Rena de [Juiz de Fora Univ., MG (Brazil). Faculdade de Medicina; Oliveira, Alexandre Ferreira de [Juiz de Fora Univ., MG (Brazil). Faculdade de Medicina. Disciplina de Cirurgia Gastroenterologica; Assis, Raimunda Violante Campos de [Juiz de Fora Univ., MG (Brazil). Faculdade de Medicina. Dept. de Patologia; Cugola, Elaine Aline; Costa, Sandra Marcia Carvalho Ribeiro

2004-07-01

30

Leiomyoma of the vagina: an unusual presentation.  

Science.gov (United States)

Vaginal leiomyomas are rare. They usually arise from the anterior vaginal wall. We report a case of a vaginal leiomyoma arising from the right lateral wall that presented as a gluteal swelling with pus discharging per vagina, creating a clinical dilemma in diagnosis. Preoperative imaging and biopsy may help to rule out malignancy. The size of the tumor necessitated abdominoperineal approach and hysterectomy for better surgical access. To the best of our knowledge such a clinical presentation of a vaginal leiomyoma has not been reported in the literature. PMID:14641688

Gowri, Raju; Soundararaghavan, Subramanium; Oumachigui, Asha; Sistla, Sarath Chandra; Iyengar, Krishnan R

2003-12-01

31

Small cell carcinoma of the vagina  

International Nuclear Information System (INIS)

A case of localized small cell neuroendocrine carcinoma of the vagina is reported. The patient was treated with concurrent chemoradiation with significant toxicity but obtained a complete response. Thirteen months after therapy the patient developed distant metastasis and died shortly thereafter. Review of the literature found that patients treated with local therapy alone had a shorter survival and died of systemic disease. As with small cell neuroendocrine carcinomas arising from other sites, systemic relapse remains an important issue that warrants combination therapies, although in pelvic sites this may be associated with an increase in side-effects. Copyright (2000) Blackwell Science Pty Ltd

2000-08-01

32

Radiotherapy of malignant tumors of the vagina  

International Nuclear Information System (INIS)

A new method of combined radiotherapy for cancer of the vagina is presented: it includes contact (intracavitary and interstitial) gamma-therapy based on the principle of the manual and automated administration (using the AGAT-B unit) of endostats and low and high activity radiation sources, and gamma irradiation with irregular shaped fields. The problems of fractionation, a choice of required irradiation volumes as well as summary absorbed dose levels are discussed. An analysis of the clinical efficacy was based delayed results. The 5-year survival rate in the general group of patients was 41.2%

1985-01-01

33

Innervation of vagina: microdissection and immunohistochemical study.  

Science.gov (United States)

The aim of this study is to elucidate the innervation of human vagina by performing a microdissection and PGP immunohistochemistry study. Seven fresh Korean cadavers were used. In five cadavers, the site at which the nerve entered the vaginal wall was observed by microdissection. Two vaginas were stained with trichrome and protein gene product 9.5 (PGP) immunostain. Terminal nerve branches in the vaginal wall were most dense at the second 1/5 partition from the inferior anterior wall (1.49 +/- 0.51/cm(2)). Its density started decreasing (0.57 +/- 0.09/cm(2) -0.89 +/- 0.46/cm(2)) and became scarce at the fourth and fifth 1/5 partitions from the bottom (0.37 +/- 0.14/cm(2)/3-0/cm(2)). The mucosa of the anterior vaginal wall at the distal 1/3 point (designated 1) was 3.50 +/- 2.06 mm in thickness and was 1.18 +/- 0.20 mm at the proximal point (designated 2). It was 1.57 +/- 0.78 mm at the distal 1/3 point (designated 3) of the lateral wall and 1.43 +/- 0.39 mm at the proximal 1/3 point (designated 4) of the posterior wall. Point 1 was thicker than 2, 3, and 4. The vaginal muscle of 1 (5.59 +/- 2.74 mm) was thicker than 2 (3.19 +/- 0.62 mm), 3 (3.31 +/- 1.31 mm), and 4 (2.98 +/- 0.33 mm). Small nerve fibers were most dense at 1 (6.5 +/- 1.1/mm(2)) and scarce at 4 (3.8 +/- 1.5/mm(2)). Large nerve fibers were most dense at 1 (1.9 +/- 0.9/mm(2)) and scarce at 2 (0.7 +/- 0.7/mm(2)) and 4 (0.7 +/- 1.0/mm(2)). The density of small nerve fibers is 2 approximately 2.9/mm(2) in the muscle and 0.7 approximately 1.5/mm(2) in large nerve fibers. The second 1/5 partition of the distal anterior wall had significantly richer innervation than the surrounding areas. Therefore, we think this 1/5 partition of the distal anterior wall could be so called "G-spot." PMID:19266382

Song, You Bong; Hwang, Kun; Kim, Dae Joong; Han, Seung Ho

2009-01-01

34

Lab-Grown Vaginas, Noses Herald New Options for Patients  

Science.gov (United States)

... vagina, said Dr. Monica Mainigi, assistant professor of obstetrics and gynecology at the Hospital of the University ... N.C.; Monica Mainigi, M.D., assistant professor, obstetrics and gynecology, Hospital of the University of Pennsylvania, ...

35

Malignant melanoma of the vagina: CT and MR findings  

International Nuclear Information System (INIS)

We report CT and MR findings in two cases of primary malignant melanoma of the vagina, one arising from cervicovaginal junction mimicking squamous cell carcinoma of the cervix and the other one recurring at vagina after resection. Two cases of malignant melanoma had high-attenuation on CT and high signal intensity on T1-weighted MR images and enhanced well after gadopentetate dimeglumine administration

1993-05-01

36

Radiation therapy for carcinoma of vagina  

International Nuclear Information System (INIS)

Thirty-four patients with carcinoma of the vagina were treated by radiotherapy at the Hyogo Medical Center for Adults between April 1965 and May 1990. All patients were treated with a combination of external and intracavitary or interstitial irradiation. Twenty-three patients had squamous cell carcinoma, five had adenocarcinoma and two had malignant melanoma. The five-year survival of patients with squamous cell carcinoma was 70% in Stage I (10 patients), 40% in Stage II (seven patients), 50% in Stage III (three patients) and 0% in Stage IV (three patients). Local control was achieved in 72.7% of the patients with squamous cell carcinoma and 60% of those with adenocarcinoma. However, neither of the malignant melanomas was controlled. Five patients had severe complications that required surgical treatment: severe proctitis and small-bowel perforation, ileus, rectal stenosis, vesicovaginal fistula and small-bowel perforation. Local and pelvic failure was noted in three patients. Patients with previous hysterectomy were more likely to develop serious treatment-related complications. (author)

1993-07-01

37

A case of small cell carcinoma of the vagina  

Directory of Open Access Journals (Sweden)

Full Text Available Primary small cell carcinoma of the vagina is quite rare, and a standard treatment has not been established yet. Herein, we report a case of an 81-year-old woman who was diagnosed with a vaginal tumor without continuity with the uterine cervix. Histopathological diagnosis indicated alveolar solid growth of nuclear chromatin-rich atypical cells with a high N/C ratio and a partially recognized rosette-like structure, suggesting a differentiated neuroendocrine system. Chromogranin A and synapto- physin were positive. Stage I vaginal small cell carcinoma localized to the vagina was diagnosed. The tumor disappeared by radiation monotherapy with external beam irradiation and endocavitary irradiation. The patient remains alive without any disease 1 year and 8 months after the treatment, suggesting the efficacy of radiotherapy in small cell carcinoma of the vagina.

Ryosuke Tamura

2013-10-01

38

Primary malignant melanoma of the vagina: a case report  

Energy Technology Data Exchange (ETDEWEB)

A primary malignant melanoma of the vagina is a very rare gynecological malignant tumor. Its clinical behavior is more aggressive than that of cutaneous and vulvar melanomas. We present a case of a large sized primary melanoma of the lower third of the vagina, with a cervical lesion, in a 58-year-old postmenopausal woman. The patient was treated with conventional external radiation therapy and intracavitary radiotherapy (lCR), without surgical treatment. Although the primary lesion showed a partial response, the patient died of extensive metastases, which were found 4.5 months after the initial diagnosis. We suggest that shortening the treatment period, such as hypofractionated radiation therapy and surgical removal, and various systemic therapies for preventing early distant metastasis, are appropriate treatments for a primary malignant melanoma of the vagina, with a large tumor size.

Jang, Ji Young; Kim, Do Kang; Lee, Eun Hee [College of Medicine, Catholic Univ., Seoul (Korea, Republic of); Kim, Jun Sang [College of Medicine, Chungnam National Univ., Daejeon (Korea, Republic of)

2003-09-01

39

Primary malignant melanoma of the vagina: a case report  

International Nuclear Information System (INIS)

A primary malignant melanoma of the vagina is a very rare gynecological malignant tumor. Its clinical behavior is more aggressive than that of cutaneous and vulvar melanomas. We present a case of a large sized primary melanoma of the lower third of the vagina, with a cervical lesion, in a 58-year-old postmenopausal woman. The patient was treated with conventional external radiation therapy and intracavitary radiotherapy (lCR), without surgical treatment. Although the primary lesion showed a partial response, the patient died of extensive metastases, which were found 4.5 months after the initial diagnosis. We suggest that shortening the treatment period, such as hypofractionated radiation therapy and surgical removal, and various systemic therapies for preventing early distant metastasis, are appropriate treatments for a primary malignant melanoma of the vagina, with a large tumor size

2003-09-01

40

Estrogen and progesterone receptors in the human vagina.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Estrogen (E) and progesterone (Pg) receptor (R) levels were determined in the human vagina in relation to menopausal status, day of ovarian cycle and pregnancy. The results obtained confirmed that the human vagina contains ER and, in addition, demonstrated for the first time the presence of PgR in this organ in humans. In cycling women, ER and PgR did not vary significantly during the ovarian cycle; however low (less than or equal to 10 fmoles/mg cytosol protein) concentrations of PgR were mo...

1985-01-01

 
 
 
 
41

MORPHOLOGICAL STUDY OF THE VAGINA OF THE Myocastor coypus (COYPU) ESTUDIO MORFOLOGICO DE LA VAGINA DE Myocastor coypus (COIPO)  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Myocastor coypus (coypu) is a medium size rodent internationally considered as a species of economic interest because its fur. The aims of this work was realized the morphological study of the vagina of coypu. The vagina of sexually mature coypus appeared as a tubular organ, 10.25±1.40 cm long. The vaginal wall was very thin. It was composed by four layers: mucosa, submucosa, muscularis, and adventitia or serosa (according to the region). The lining epithelium of the mucosa was squamous ...

Felipe, Antonio E.; Alejandra Castro; Callejas, Santiago S.; Cabodevila, Jorge A.

2000-01-01

42

Primary melanoma of the vagina. A clinical case  

Directory of Open Access Journals (Sweden)

Full Text Available Primary melanoma of the vagina is a rare neoplasm that appears in the 6th and 7th decades of life. It has a poor prognosis, for which there is no consensus regarding treatment; indeed, the literature describes a number of therapeutic options. This paper describes a patient with vaginal melanoma treated by local excision and immunotherapy.

Isabel Alemany

2011-03-01

43

Nanoparticle transport from mouse vagina to adjacent lymph nodes.  

Science.gov (United States)

To test the feasibility of localized intravaginal therapy directed to neighboring lymph nodes, the transport of quantum dots across the vaginal wall was investigated. Quantum dots instilled into the mouse vagina were transported across the vaginal mucosa into draining lymph nodes, but not into distant nodes. Most of the particles were transported to the lumbar nodes; far fewer were transported to the inguinal nodes. A low level of transport was evident at 4 hr after intravaginal instillation, and transport peaked at about 36 hr after instillation. Transport was greatly enhanced by prior vaginal instillation of Nonoxynol-9. Hundreds of micrograms of nanoparticles/kg tissue (ppb) were found in the lumbar lymph nodes at 36 hr post-instillation. Our results imply that targeted transport of microbicides or immunogens from the vagina to local lymph organs is feasible. They also offer an in vivo model for assessing the toxicity of compounds intended for intravaginal use. PMID:23284844

Ballou, Byron; Andreko, Susan K; Osuna-Highley, Elvira; McRaven, Michael; Catalone, Tina; Bruchez, Marcel P; Hope, Thomas J; Labib, Mohamed E

2012-01-01

44

A case of postirradiated malignant fibrous histiocytoma of the vagina  

International Nuclear Information System (INIS)

An unusual case of postirradiated malignant fibrous histiocytoma of the vagina in a 72-year-old female is reported. The tumor occurred in the radiation field 30 years after radical hysterectomy and preoperative radiation therapy (radium 5,200 mgh) for squamous cell carcinoma of the uterine cervix. She had been disease free for 30 years until she noticed a large mass in the vagina. Cytological study showed mainly two types of non-epithelial malignant cells; spindle-shaped fibroblast-like cells and histiocyte-like cells. Bizarre mono or multinucleated giant cells were often observed. The operative specimen revealed an arrangement composed of short or long spindle cells and vacuolated mononucleated and large multinucleated cells. The diagnosis was comfirmed by immunohistological and ultrastructural study. We have reviewed the literature on malignant fibrous histiocytoma occurring after radiation for cervical carcinoma. (author)

1992-11-01

45

Primary Melanoma of the Vagina Treated by Imatinib: Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available Melanoma of the vagina is a rare lesion. It results from the malignant transformation of ectopic melanocytes occurring in post-menopause. The CKIT is expressed in 36% of cases in addition to melanoma markers. Prognosis is poor especially for inoperable and disseminated forms despite systemic therapy. Treatment with Imatinib is an option in cases of metastatic mucosal melanoma with CKIT mutation or amplification. We report the case of post-menopausal women, treated at Hassan II University Hospital, diagnosed with metastatic melanoma of the vagina, that didn’t respond to first line of chemotherapy, and received Imatinib as second line of treatment, with good clinical response and durable stability at radiological assessment.

Karima Oualla

2013-08-01

46

Interstitial radiotherapy of malignant tumors of the vagina  

International Nuclear Information System (INIS)

A total of 65 patients with malignant tumors of the vagina aged 32 to 81 years were treated by interstitial radiotherapy. Out of the 65 subjects, 52 patients were irradiated with 60Co sources, and 13 patients with 252Cf sources. Fixing devices of three types were used which ensured practical implementation of interstitial radiotherapy in regard to tumor location, its shape, and volume. Complete tumor regression occurred in 54 patients (83.1%) and partial regression was observed in 9 patients (13.8%). Mild radiation reactions were found in 17 patients (26.1%). No effect was observed in 2 patients (3.1%). In one case a necrotic radiation ulcer developed. Based on the above data, the conclusion was drawn that interstitial radiotherapy represents the treatment of choice in malignant tumors of the vagina. (author). 6 figs., 2 tabs., 19 refs

1989-01-01

47

Management of radionecrosis of the vulva and distal vagina  

Energy Technology Data Exchange (ETDEWEB)

Twelve patients were seen between January 1983 and June 1989 with the clinical diagnosis of radionecrosis of the vulva or distal vagina. Seven patients received radiation for vulvar cancer, three for distal vaginal cancer, and two for recurrent endometrial cancer. No patient healed spontaneously and the mean delay in surgical therapy was 8.5 months. The radionecrotic site was treated with local therapy, radical local excision (with or without colostomy), or exenteration. The operative defect was closed primarily in three patients and covered with local flaps or myocutaneous flaps in seven patients. The two patients with local care still have radionecrotic ulcers. One of three patients who were closed primarily continues to have an ulcer. All other patients have healed satisfactorily except one who died after two attempts to correct the problem. Radionecrosis of the vulva and distal vagina should generally be treated surgically.

Roberts, W.S.; Hoffman, M.S.; LaPolla, J.P.; Ruas, E.; Fiorica, J.V.; Cavanagh, D. (Univ. of South Florida, Tampa (USA))

1991-05-01

48

Management of radionecrosis of the vulva and distal vagina  

International Nuclear Information System (INIS)

Twelve patients were seen between January 1983 and June 1989 with the clinical diagnosis of radionecrosis of the vulva or distal vagina. Seven patients received radiation for vulvar cancer, three for distal vaginal cancer, and two for recurrent endometrial cancer. No patient healed spontaneously and the mean delay in surgical therapy was 8.5 months. The radionecrotic site was treated with local therapy, radical local excision (with or without colostomy), or exenteration. The operative defect was closed primarily in three patients and covered with local flaps or myocutaneous flaps in seven patients. The two patients with local care still have radionecrotic ulcers. One of three patients who were closed primarily continues to have an ulcer. All other patients have healed satisfactorily except one who died after two attempts to correct the problem. Radionecrosis of the vulva and distal vagina should generally be treated surgically

1991-01-01

49

Radiosterilisation of the vagina in therapeutic doses - does it exist  

International Nuclear Information System (INIS)

The endogenous genital flora is a major source of infections of the female genital tract, especially in patients with cervical or endometrial cancer. Until recently the 'radiosterilisation of the vagina', respectively a prophylactic and/or therapeutic effect of irradiation (external highvoltage as well as intracavitary-radium) concerning infections was postulated in the literature. This theory was disproved in a prospective clinical and bacteriological study covering 48 patients with advanced cervical cancer undergoing primary intracavitary radium-irradiation and 38 patients with inoperable endometrical cancer, undergoing primary iridium-192-afterloading. Following intracavitary radium for cervical cancer some typical nosocomial pathogens like Streptococcus faecalis, Enterobacter, Klebsiella, Proteus and Pseudomonas were isolated significantly more frequently than before treatment. Likewise, the mean number of aerobic bacterial species increased significantly after irradiation. Also primary Ir-192 (afterloading) irradiation did not alter the frequency of isolation of the resident flora in endometrial cancer patients. Therefore, 'radiosterilisation' of the vagina as result of radiotherapy does not exist. (orig.)

1986-01-01

50

[Leiomyoma can also be located in the vagina].  

Science.gov (United States)

Vaginal wall leiomyomas are rare. They are typically located in the anterior or lateral wall of the vagina. We report a case of a posterior vaginal leiomyoma which was mistaken for a cervical fibroma. Despite several examinations and biopsies to rule out a potential malignant condition, the diagnosis was delayed. Whenever there is a clinical suspicion of a vaginal leiomyoma, magnetic resonance imaging or translabial ultrasound are the recommended imaging modalities. PMID:21627916

Sørensen, Marie; Chauhan, Priya

2011-05-23

51

Nanoparticle Transport from Mouse Vagina to Adjacent Lymph Nodes  

Digital Repository Infrastructure Vision for European Research (DRIVER)

To test the feasibility of localized intravaginal therapy directed to neighboring lymph nodes, the transport of quantum dots across the vaginal wall was investigated. Quantum dots instilled into the mouse vagina were transported across the vaginal mucosa into draining lymph nodes, but not into distant nodes. Most of the particles were transported to the lumbar nodes; far fewer were transported to the inguinal nodes. A low level of transport was evident at 4 hr after intravaginal instillation,...

2012-01-01

52

Borderline malignant change in recurrent müllerian papilloma of the vagina.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Malignant change occurred in a benign, recurrent vaginal müllerian polyp. The patient, a 49 year old woman with cerebral palsy, presented with a polypoid mass in the vagina. At four years of age she had presented with a haemorrhagic polyp, and over the following years she had recurrent irregular bleeding and regrowth of the polypoidal mass, requiring a total of 10 operations to excise the polyp. Histological examination of the specimen showed typical müllerian features with tubal, endometri...

1998-01-01

53

Propranolol concentrations in plasma after insertion into the vagina.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Six healthy women participated in a study of the concentrations of propranolol achieved in plasma after insertion of the drug into the vagina. In four of the women the concentrations were also determined after administration by mouth. The area under the concentration curve for propranolol administered per vaginam was significantly greater than that after oral administration. There were small significant reduction in systolic blood pressure, pulse rate, and forced expiratory volume in one seco...

Patel, L. G.; Warrington, S. J.; Pearson, R. M.

1983-01-01

54

A case of small cell carcinoma of the vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Primary small cell carcinoma of the vagina is quite rare, and a standard treatment has not been established yet. Herein, we report a case of an 81-year-old woman who was diagnosed with a vaginal tumor without continuity with the uterine cervix. Histopathological diagnosis indicated alveolar solid growth of nuclear chromatin-rich atypical cells with a high N/C ratio and a partially recognized rosette-like structure, suggesting a differentiated neuroendocrine system. Chromogranin A and synap...

Ryosuke Tamura; Yoshihito Yokoyama; Asami Kabayashi; Yuuki Osawa; Tatsuhiko Shigeto; Masayuki Futagami; Hideki Mizunuma

2013-01-01

55

Malignant peripheral nerve sheath tumor of the vagina  

International Nuclear Information System (INIS)

Malignant peripheral nerve sheath tumors (MPNSTs) usually develop in major nerve trunks, giving rise to tumors in the proximal portions of the upper and lower extremities and trunk. The MPNSTs primarily occurring in the female genital tract are quite rare. We describe a case of MPNST of the vagina and discuss its diagnosis and treatment. This patient was treated definitively with radical local excision and is well with no signs of recurrence 2 years postoperatively. (author)

2009-01-01

56

Radiation therapy in primary carcinoma of the vagina  

International Nuclear Information System (INIS)

The experiences with irradiation of 25 patients with primary carcinoma of the vagina are presented. The 3-year survival was 36 per cent despite the fact that most of the cases were advanced. Further improvements in survival may probably be achieved with extension of the radium implantation to paravaginal tissues. Choice and technique of treatment must be individualized. Surgery is limited to the more advanced cases with involvement of the bladder and rectum. (Auth.)

1982-01-01

57

Primary Melanoma of the Vagina Treated by Imatinib: Case Report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Melanoma of the vagina is a rare lesion. It results from the malignant transformation of ectopic melanocytes occurring in post-menopause. The CKIT is expressed in 36% of cases in addition to melanoma markers. Prognosis is poor especially for inoperable and disseminated forms despite systemic therapy. Treatment with Imatinib is an option in cases of metastatic mucosal melanoma with CKIT mutation or amplification. We report the case of post-menopausal women...

Karima Oualla; Fatimazahra El’mrabet; Hind Elfatemi; Samia Arifi; Nawfel Mellas; Abdelaziz Banani; Siham Tizniti; Afaf Amarti; Omar Elmesbahi

2013-01-01

58

Sensibility of vagina reconstructed by McIndoe method in Mayer-Küster-Rokitansky-Hauser syndrome  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background/Aim. Congenital absence of vagina is a failure present in Mayer-Küster-Rokitansky-Hauser syndrome. Treatment of this anomaly includes nonoperative and operative procedures. McIndoe procedure uses split skin graft by Thiersch. The aim of this study was to determine sensitivity (touch, warmness, coldness) of a vagina reconstructed by McIndoe method in Mayer-Küster-Rokitansky-Hauser syndrome and compare it with the normal vagina. Methods. A total of 21 female persons with reconstruc...

Vesanovi? Svetlana; Panajotovi? Ljubomir; Garaleji? Elijana

2008-01-01

59

Fibroepithelial polyps of the vagina: are they old granulation tissue polyps?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

AIMS: To study the nature of fibroepithelial polyps of the vagina. METHODS: Sixty five fibroepithelial polyps of the vagina and 64 granulation tissue polyps diagnosed over 15 years were reviewed histologically. RESULTS: Cytologically benign multinucleated stromal cells were present in large numbers in 19 of the fibroepithelial polyps of the vagina (FEPV). Only one polyp contained atypical stromal cells, a high mitotic count, and abnormal mitoses and was indistinguishable from a malignant tumo...

Halvorsen, T. B.; Johannesen, E.

1992-01-01

60

Endodermal sinus tumor of the vagina in children: A report of two cases  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Malignant tumors of the vagina in infants and children are rare, with primary germ cell tumor (endodermal sinus tumor [EST]) being rarer, which carries a dismal prognosis. This tumor is often clinically mistaken as botryoid rhabdomyosarcoma and, on histopathological examination, is often misdiagnosed as clear cell adenocarcinoma. Two cases of EST of the vagina in infants aged 9 and 17 months are reported. Both the patients presented with bleeding per vagina and clinically and by ultrasonograp...

Gangopadhyay Mimi; Raha Kalpana; Sinha Swapan; De Anuradha; Bera Pranati; Pati Shyamapada

2009-01-01

 
 
 
 
61

Sensibility of vagina reconstructed by McIndoe method in Mayer-Küster-Rokitansky-Hauser syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available Background/Aim. Congenital absence of vagina is a failure present in Mayer-Küster-Rokitansky-Hauser syndrome. Treatment of this anomaly includes nonoperative and operative procedures. McIndoe procedure uses split skin graft by Thiersch. The aim of this study was to determine sensitivity (touch, warmness, coldness of a vagina reconstructed by McIndoe method in Mayer-Küster-Rokitansky-Hauser syndrome and compare it with the normal vagina. Methods. A total of 21 female persons with reconstructed vagina by McIndoe method and 21 female persons with normal vagina were observed. All female persons were divided into groups and subgroups (according to age. Sensibility to touch, warmness and coldness were examined, applying VonFrey's esthesiometer and termoesthesiometer for warmness and coldness in three regions of vagina (enter, middle wall, bothom. The number of positive answers was registrated by touching the mucosa regions for five seconds, five times. Results. The obtained results showed that female patients with a reconstructed vagina by McIndoe method, felt touch at the middle part of wall and in the bottom of vagina better than patients with normal one. Also, the first ones felt warmness at the middle part of wall and coldness in the bottom of vagina, better than the patients with normal vagina. Other results showed no difference in sensibility between reconstructed and normal vagina. Conclusion. Various types of sensibility (touch, warmness, coldness are better or the same in vaginas reconstructed by McIndoe method, in comparison with normal ones. This could be explained by the fact that skin grafts are capable of recovering sensibility.

Vesanovi? Svetlana

2008-01-01

62

Radiation treatment of primary carcinoma of the vagina  

International Nuclear Information System (INIS)

Patterns of failures after definitive radiation therapy were analyzed in 88 patients with primary carcinoma of the vagina treated between 1957 and 1975. The majority of the local failures in early stages of the disease (I, II and a few III) were due to inadequate treatment either by external beam therapy or brachytherapy. In some cases the inadequate treatments were unavoidable (previous radiation treatment) and in a few they were due to poor brachytherapy technique. Distant failures are still a problem and need to be given further attention. (orig.)

1985-01-01

63

Management of radiation injuries of vulva and vagina  

Energy Technology Data Exchange (ETDEWEB)

Background: Acute and late injuries of vulva and vagina are frequent and potentially serious complications in radiotherapy of gynecologic tumors. They still are reported poorly in literature. Methods: Based on a literature search a survey will be given of the modalities, which are used or recommended for prophylaxis or treatment of these radiation injuries. The principles of the different measures will be discussed with available study results. Results: Hygiene measures and the topical application of antimicrobial or granulation stimulating substances, which is mostly based on long standing clinical experience, are the principles of the treatment of acute reactions of vulva and vagina. The topical use of estrogen, which promotes proliferation of epithelium, is generally described in connection with treatment and prophylaxis of late radiation injuries. As a prophylaxis for the late reaction of vaginal stenosis, vaginal dilatation is recommended in literature. Conclusion: With the exception of a few reports on estrogen, there are no data about the effectiveness of the currently used medical substances. The local application of estrogen as prophylaxis of the acute reactions will therefore be examined in a prospective study. (orig.) [Deutsch] Hintergrund: Akute und spaete Reaktionen an Vulva und Vagina sind haeufige und zum Teil schwerwiegende Nebenwirkungen der Strahlentherapie von gynaekologischen Tumoren, auf die in der Literatur kaum eingegangen wird. Methoden: Basierend auf einer umfangreichen Literaturrecherche, werden die Massnahmen, die zur Prophylaxe oder Therapie dieser Strahlenreaktionen zur Verfuegung stehen, systematisch zusammengestellt und, soweit verfuegbar, mit Ergebnissen aus Studien diskutiert. Ergebnisse: Hygienemassnahmen und die auf klinischen Erfahrungswerten basierende lokale Anwendung einer Vielzahl von mehr oder weniger antimikrobiell wirkenden oder granulationsfoerdernden Substanzen lassen sich als Grundprinzipien der Behandlung von akuten Reaktionen an Vulva und Vagina erkennen. Der Einsatz von lokalen Oestrogenapplikationen, die die hormonabhaengige Proliferation des Epithels ausnutzen, wird ueberwiegend im Zusammenhang mit Therapie und Prophylaxe von radiogenen Spaetfolgen beschrieben. Als eine Art der Prophylaxe von Spaetreaktionen in Form der Vaginalstenose hat sich die Empfehlung der vaginalen Dilatation etabliert. Schlussfolgerungen: Mit Ausnahme von einigen Arbeiten zu Oestrogen gibt es keine Daten ueber die Wirksamkeit der eingesetzten Substanzen. Die lokale Oestrogenapplikation zur Prophylaxe der akuten Strahlenreaktionen wird daher in einer prospektiven Studie untersucht werden. (orig.)

Fraunholz, I.B.; Schopohl, B.; Boettcher, H.D. [Klinik fuer Strahlentherapie und Onkologie, Johann-Wolfgang-Goethe-Universitaet Frankfurt am Main (Germany)

1998-11-01

64

Normal tissue tolerance to external beam radiation therapy: The vagina  

International Nuclear Information System (INIS)

The vagina is a virtual cavity involved in sexual reproduction field. Due to its anatomical location, it may be exposed in whole or in part to ionizing radiation in external radiotherapy and/or brachytherapy of the pelvic region. This review aims to describe the vaginal acute and late side effects due to radiation, probably inadequately reported in the literature. Medline and PubMed literature searches were performed using the keywords -vaginal - radiotherapy - toxicity. The acute and late functional changes after external beam radiation consist mainly of drought. Their incidences are poorly described in the literature and the delivered doses even less. Recommendations are non-existent as the normal tissue complication probability (NTCP). Brachytherapy delivers high and heterogeneous doses, making it difficult to estimate the dose. The concomitant administration of chemotherapy appears to be a factor increasing the risk of toxicity. Modern techniques of conformal radiotherapy with modulated intensity appear to have little impact on this body. Only a maximum dose on each third of the vagina appears to be currently proposed to avoid the risk of side effects. (authors)

2010-07-01

65

Management of radiation injuries of vulva and vagina  

International Nuclear Information System (INIS)

Background: Acute and late injuries of vulva and vagina are frequent and potentially serious complications in radiotherapy of gynecologic tumors. They still are reported poorly in literature. Methods: Based on a literature search a survey will be given of the modalities, which are used or recommended for prophylaxis or treatment of these radiation injuries. The principles of the different measures will be discussed with available study results. Results: Hygiene measures and the topical application of antimicrobial or granulation stimulating substances, which is mostly based on long standing clinical experience, are the principles of the treatment of acute reactions of vulva and vagina. The topical use of estrogen, which promotes proliferation of epithelium, is generally described in connection with treatment and prophylaxis of late radiation injuries. As a prophylaxis for the late reaction of vaginal stenosis, vaginal dilatation is recommended in literature. Conclusion: With the exception of a few reports on estrogen, there are no data about the effectiveness of the currently used medical substances. The local application of estrogen as prophylaxis of the acute reactions will therefore be examined in a prospective study. (orig.)

1998-11-01

66

Primary Small Cell Neuroendocrine Carcinoma of Vagina: A Rare Case Report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Primary small cell neuroendocrine carcinoma of vagina is an extremely rare disease. There have been only 26 previously reported cases in literature. Here, we report a case of primary small cell neuroendocrine carcinoma of vagina. Immunohistochemistry (IHC) showed tumor cells positive for synaptophysin, chromogranin, and neuron-specific enolase (NSE).

Bhalodia, Jignasa N.; Kapapura, Dhiren V.; Parekh, Malay N.

2011-01-01

67

Urethral substitution with ileum in traumatic bladder neck-vagina fistula  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A five-year-old girl presented with post traumatic urinary incontinence secondary to rupture of the bladder neck into the vagina. Operative repair included a midline exposure with resection of the symphysis pubis, separation of the bladder neck from the vagina, repair of the torn bladder neck and urethral substitution with ileum. Normal continence and voiding was achieved.

Kannaiyan, Lavanya; Sen, Sudipta

2009-01-01

68

Urethral substitution with ileum in traumatic bladder neck-vagina fistula  

Directory of Open Access Journals (Sweden)

Full Text Available A five-year-old girl presented with post traumatic urinary incontinence secondary to rupture of the bladder neck into the vagina. Operative repair included a midline exposure with resection of the symphysis pubis, separation of the bladder neck from the vagina, repair of the torn bladder neck and urethral substitution with ileum. Normal continence and voiding was achieved.

Kannaiyan Lavanya

2009-01-01

69

Inseminación artificial de alpacas con semen colectado por aspiración vaginal y vagina artificial / Artificial insemination of alpacas with semen collected by vaginal aspiration and by artificial vagina  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Semen de alpaca fue colectado por dos métodos: por aspiración de la vagina de la hembra después de la monta natural y con vagina artificial. El semen colectado fue evaluado y diluido con Tris tamponado, y luego usado en inseminacion artificial. Se trabajó con 160 alpacas hembras adultas de capacidad [...] reproductiva comprobada y 5 alpacas machos. Se colectó semen post cópula de los cinco machos en 10 hembras, y se hicieron 50 colecciones de semen con vagina artificial de estos machos, dos veces por semana. Se determinó volumen, motilidad, concentración espermática, porcentaje de espermatozoides vivos, viscosidad y color. Los resultados para semen colectado por aspiración de la vagina y con vaginal artificial fueron: volumen (3.6 y 1.5 mL), motilidad (73.4 y 69.0%), concentración espermática (75.2 y 80.3 millones/mL), espermatozoides vivos (75.3 y 70.8%), respectivamente, con diferencia entre métodos (p Abstract in english Semen from alpacas was collected by two methods: by aspiration from the female?s vagina following mating and with an artificial vagina. Semen was collected, evaluated and extended with Tris buffer, and then used in artificial insemination. Altogether 160 female alpacas with proven reproductive histo [...] ry and five males were used. Semen was collected by vaginal aspiration from 10 females using five males as semen donors; likewise, semen from the same males was collected with an artificial vagina twice a week 50 times. Volume, motility, spermatic concentration, live spermatozoa, viscosity and color was evaluated. Seminal characteristics of semen collected by aspiration and with an artificial vagina were: volume (3.6 and 1.5 mL), motility (73.4 and 69.0%), sperm concentration (75.2 and 80.3 million/mL), live spermatozoa (75.3 and 70.8%) respectively, with statistical difference between methods (p

Alarcón B, Virgilio; García V, Wilber; Bravo, P. Walter.

70

Melanosis of the vagina and human papillomavirus infection, an uncommon pathology: Case Report Melanosis de la vagina e infección por virus del papiloma humano, una patología poco común: Reporte de un Caso  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Benign melanotic lesions of the vagina are uncommon and only a few cases have been reported in the literature. A 34-year-old woman was referred because of a Vaginal Intraepithelial Neoplasia 1 biopsy result. On the gynecological examination, two different hyperpigmented areas were noted in the vagina. The colposcopic visualization of the cervix and vagina found an aceto-white lesion at the right lateral wall of the upper third of the vagina. Biopsies from three areas were taken. Histological ...

José Núñez-Troconis; Mariela Delgado; Gerardo González; Airiaudis Rivas; Katherine Molero

2011-01-01

71

Spindle Cell Epithelioma of the Vagina Shows Immunohistochemical Staining Supporting Its Origin From a Primitive/Progenitor Cell Population.  

Science.gov (United States)

Spindle cell epitheliomas of the vagina (SCEVs) coexpresses epithelial and mesenchymal markers and were first described as a 'mixed tumors of the vagina.' However, unlike mixed tumors of other organs, which are believed to originate from myoepithelial cel...

H. Skelton K. J. Smith

2001-01-01

72

Definitive radiation therapy for squamous cell carcinoma of the vagina  

International Nuclear Information System (INIS)

Purpose: To evaluate outcome and describe clinical treatment guidelines for patients with primary squamous cell carcinoma of the vagina treated with definitive radiation therapy. Methods and Materials: Between 1970 and 2000, a total of 193 patients were treated with definitive radiation therapy for squamous cell carcinoma of the vagina at The University of Texas M. D. Anderson Cancer Center. The patients' medical records were reviewed to obtain information about patient, tumor, and treatment characteristics, as well as outcome and patterns of recurrence. Surviving patients were followed for a median of 137 months. Survival rates were calculated using the Kaplan-Meier method, with differences assessed using log-rank tests. Results: Disease-specific survival (DSS) and pelvic disease control rates correlated with International Federation of Gynecology and Obstetrics (FIGO) stage and tumor size. At 5 years, DSS rates were 85% for the 50 patients with Stage I, 78% for the 97 patients with Stage II, and 58% for the 46 patients with Stage III-IVA disease (p = 0.0013). Five-year DSS rates were 82% and 60% for patients with tumors ?4 cm or >4 cm, respectively (p = 0.0001). At 5 years, pelvic disease control rates were 86% for Stage I, 84% for Stage II, and 71% for Stage III-IVA (p = 0.027). The predominant mode of relapse after definitive radiation therapy was local-regional (68% and 83%, respectively, for patients with stages I-II or III-IVA disease). The incidence of major complications was correlated with FIGO stage; at 5 years, the rates of major complications were 4% for Stage I, 9% for Stage II, and 21% for Stage III-IVA (p < 0.01). Conclusions: Excellent outcomes can be achieved with definitive radiation therapy for invasive squamous cell carcinoma of the vagina. However, to achieve these results, treatment must be individualized according to the site and size of the tumor at presentation and the response to initial external-beam radiation therapy. Brachytherapy plays an important role in the treatment of many vaginal cancers but should be carefully selected and applied to obtain optimal coverage of the target volume

2005-05-01

73

Malignant melanoma of the vagina: a report of 2 cases  

Energy Technology Data Exchange (ETDEWEB)

Primary malignant melanoma of the vagina is an extremely rare genital neoplasm occurring mainly in postmenopausal women. It has a worse prognosis than cutaneous melanomas, because of the high rate of locoregional recurrences and rapid systemic dissemination. In the past, radical surgical extirpation as the primary management had been recommended to improve loco-regional control, and possibly overall survival. However, the prognosis was poor in spite of such a radical approach. Recently, more conservative treatment such as wide local excision combined with adjuvant high-dose fraction radiotherapy seems to have promising results. Primary radiation therapy could be served as an alternative to surgery for patients with lesion less than 3 cm in diameter. We report 2 cases of primary vaginal malignant melanoma treated with radiotherapy.

Kim, Ok Bae; Kim, Jin Hee; Jung, Young Yeon; Cho, Chi Heum; Choi, Tae Jin [Dongsan Medical Center, School of Medicine, Keimyung University, Daegu (Korea, Republic of)

2005-06-15

74

Malignant melanoma of the vagina: a report of 2 cases  

International Nuclear Information System (INIS)

Primary malignant melanoma of the vagina is an extremely rare genital neoplasm occurring mainly in postmenopausal women. It has a worse prognosis than cutaneous melanomas, because of the high rate of locoregional recurrences and rapid systemic dissemination. In the past, radical surgical extirpation as the primary management had been recommended to improve loco-regional control, and possibly overall survival. However, the prognosis was poor in spite of such a radical approach. Recently, more conservative treatment such as wide local excision combined with adjuvant high-dose fraction radiotherapy seems to have promising results. Primary radiation therapy could be served as an alternative to surgery for patients with lesion less than 3 cm in diameter. We report 2 cases of primary vaginal malignant melanoma treated with radiotherapy

2005-06-01

75

Radiation Therapy of Primary Carcinoma of the Vagina  

International Nuclear Information System (INIS)

A retrospective study was carried out of 20 patients with histologically proven invasive carcinoma of the vagina from 1979 to 1993; 17 cases with curative primary radiotherapy and three cases with postoperative radiotherapy. The five and ten year overall survival rates were 79% and 53%, respectively. Survival was strongly correlated with stage. Five year survival rates of stage I, stage II, and stage III, IV were 100%, 78%, and 0%, respectively. Eight patients experienced recurrences; five within the irradiated volume, two distant metastasis, and one combined both local and distant metastasis. There was no significant late complication. From these data, radiation is effective in the management of the vaginal cancer patients and optimum treatment modality and total dose recommendation are made

1995-03-01

76

Radiation therapy in primary carcinoma of the vagina  

International Nuclear Information System (INIS)

A retrospective analysis of 32 patients with carcinoma of the vagina treated with curative radiotherapy between 1965 and 1981 is presented. Squamous cell carcinoma was the most common histologic type, found in 78% of the patients. Patients were staged according to the FIGO system. Stage I and II disease was found in 8 and 18 patients, respectively. Six patients had either Stage III or IV disease. The absolute survival rate was 100% for Stage I and 72% for Stage II patients. The pattern of failure was analyzed. All patients who failed had done so within 14 months of completion of treatment. Treatment failure in the pelvis occurred only in 16% of the patients with early disease (Stages I and II) while 81% of the patients with late stage had failed in the pelvis

1987-01-01

77

Radiation-induced morphological changes in the vagina  

Energy Technology Data Exchange (ETDEWEB)

Background and purpose: Treatment-induced chronic vaginal changes after definitive radio(chemo)therapy for locally advanced cervical cancer patients are reported as one of the most distressing consequences of treatment, with major impact on quality of life. Although these vaginal changes are regularly documented during gynecological follow-up examinations, the classic radiation morbidity grading scales are not concise in their reporting. The aim of the study was therefore to identify and qualitatively describe, on the basis of vaginoscopies, morphological changes in the vagina after definitive radio(chemo)therapy and to establish a classification system for their detailed and reproducible documentation. Patients and methods: Vaginoscopy with photodocumentation was performed prospectively in 22 patients with locally advanced cervical cancer after definitive radio(chemo)therapy at 3-24 months after end of treatment. All patients were in complete remission and without severe grade 3/4 morbidity outside the vagina. Results: Five morphological parameters, which occurred consistently after treatment, were identified: mucosal pallor, telangiectasia, fragility of the vaginal wall, ulceration, and adhesions/occlusion. The symptoms in general were observed at different time points in individual patients; their quality was independent of the time of assessment. Based on the morphological findings, a comprehensive descriptive and semiquantitative scoring system was developed, which allows for classification of vaginal changes. A photographic atlas to illustrate the morphology of the alterations is presented. Conclusion: Vaginoscopy is an easily applicable, informative, and well-tolerated procedure for the objective assessment of morphological vaginal changes after radio(chemo)therapy and provides comprehensive and detailed information. This allows for precise classification of the severity of individual changes. (orig.)

Kirchheiner, K.; Fidarova, E.; Schmid, M.P.; Sturdza, A.; Kranz, A.; Poetter, R. [Medical Univ. of Vienna (Austria). Dept. of Radiation Oncology; Nout, R.A. [University Medical Center Leiden (Netherlands). Dept. of Clinical Oncology; Wiebe, E. [Alberta Univ., Cross Cancer Institute, Edmonton, AB (Canada). Dept. of Radiation Oncology; Polterauer, S. [Medical Univ. of Vienna (Austria). Dept. of General Gynecology and Gynecologic Oncology; Doerr, W. [Medical Univ. of Vienna (Austria). Dept. of Radiation Oncology; Medical Univ. of Vienna (Austria). Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology

2012-11-15

78

Radiation-induced morphological changes in the vagina  

International Nuclear Information System (INIS)

Background and purpose: Treatment-induced chronic vaginal changes after definitive radio(chemo)therapy for locally advanced cervical cancer patients are reported as one of the most distressing consequences of treatment, with major impact on quality of life. Although these vaginal changes are regularly documented during gynecological follow-up examinations, the classic radiation morbidity grading scales are not concise in their reporting. The aim of the study was therefore to identify and qualitatively describe, on the basis of vaginoscopies, morphological changes in the vagina after definitive radio(chemo)therapy and to establish a classification system for their detailed and reproducible documentation. Patients and methods: Vaginoscopy with photodocumentation was performed prospectively in 22 patients with locally advanced cervical cancer after definitive radio(chemo)therapy at 3-24 months after end of treatment. All patients were in complete remission and without severe grade 3/4 morbidity outside the vagina. Results: Five morphological parameters, which occurred consistently after treatment, were identified: mucosal pallor, telangiectasia, fragility of the vaginal wall, ulceration, and adhesions/occlusion. The symptoms in general were observed at different time points in individual patients; their quality was independent of the time of assessment. Based on the morphological findings, a comprehensive descriptive and semiquantitative scoring system was developed, which allows for classification of vaginal changes. A photographic atlas to illustrate the morphology of the alterations is presented. Conclusion: Vaginoscopy is an easily applicable, informative, and well-tolerated procedure for the objective assessment of morphological vaginal changes after radio(chemo)therapy and provides comprehensive and detailed information. This allows for precise classification of the severity of individual changes. (orig.)

2012-11-01

79

Internal motion of the vagina after hysterectomy for gynaecological cancer  

International Nuclear Information System (INIS)

Background and purpose: The purpose of this study was to investigate position changes of the vagina after hysterectomy for early stage cervical or endometrial cancer and their impact on CTV-PTV margins. We also studied their correlation with surrounding organ filling. Materials and methods: Fifteen patients underwent T2-weighted MR scans before and weekly during the course of their EBRT. The vaginal CTVs and the surrounding organs were delineated. PTV margins were derived from the boundaries of the CTVs in the main directions and correlated with changes in the volumes of organs at risk. Additionally we investigated the impact of margin sizes on CTV coverage. Results: The vaginal CTVs change their position in the pelvis during time with a maximum in anterior-posterior direction. The 95% confidence level was 2.3 cm into the anterior or posterior direction, 1.8 cm to left or right and 1.5 cm towards the cranial. With a homogenous 1.5 cm CTV-PTV margin ?5% inadequately covered vaginal CTV was seen in only 3.3% of the measurements. This increased to 20.6% with a margin of 1.0 cm. Concerning the impact of organ filling on vaginal position changes we found the only significant correlation with rectal volume and shift of the vagina towards anterior-posterior. Conclusion: To accommodate the changes in the position of the vaginal CTV inhomogeneous PTV margins should be generated with the largest size in the anterior-posterior direction. The position shifts were only weakly related to the volume of the rectum and not at all to the volumes of other parts of the bowel and the bladder.

2011-02-01

80

High-dose-rate brachytherapy for cervical carcinoma patients with narrow vagina  

Energy Technology Data Exchange (ETDEWEB)

We retrospectively analyzed cervical cancer patients with narrow vagina treated by high-dose-rate (HDR) brachytherapy followed by external beam irradiation. Fifty patients were treated with radical radiotherapy between 1992 and 1999 at the National Tokyo Medical Center. All patients received 30 Gy of external whole pelvic irradiation and 20 Gy of pelvic irradiation with a central shield. After 30 Gy of whole pelvic irradiation, 24 Gy of fractionated brachytherapy was applied with a tandem and ovoids, non-rigid type developed in the Cancer Institute, according to the Manchester method. Nineteen patients with a narrow vagina of less than 40 mm in width were compared with 31 other patients (control group). The 5-year cumulative survival rates were 56% in the patients with a narrow vagina and 53% in the control group (P=0.6008). The control rate in the pelvis was not significantly different between the two groups. The cumulative rate of rectal complications of the patients with a narrow vagina was more frequent than the control group (58% vs 29%) (P=0.0924). Severe rectal bleeding was also more frequent in the patients with a narrow vagina. The estimated maximal dose of the rectal wall was significantly higher in patients with a narrow vagina. This result suggests that a lower brachytherapy dose is necessary for patients with narrow vagina considering the rectal sequelae in the case of using our methods. (author)

Yorozu, Atsunori; Toya, Kazuhito; Kawase, Takatugu [National Tokyo Medical Center, Tokyo (Japan); Dokiya, Takushi [Saitama Medical Coll., Moroyama (Japan)

2002-06-01

 
 
 
 
81

Anatomic and histological characteristics of vagina reconstructed by McIndoe method  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background/Aim. Congenital absence of vagina is known from ancient times of Greek. According to the literature data, incidence is 1/4 000 to 1/20 000. Treatment of this anomaly includes non-operative and operative procedures. McIndoe procedure uses split skin graft by Thiersch. The aim of this study was to establish anatomic and histological characteristics of vagina reconstructed by McIndoe method in Mayer Küster-Rockitansky Hauser (MKRH) syndrome and compare them with normal vagina. Method...

Kozarski Jefta; Vesanovi? Svetlana; Bogdanovi? Zoran

2009-01-01

82

The present-day technologies of brachytherapy for primary and metastatic carcinoma of the vagina  

International Nuclear Information System (INIS)

Results of brachytherapy of 133 patients with primary vaginal carcinoma, 137 - with cervical metastasis into the vagina, and 132 cases of endometrial metastasis into the vagina, and 132 cases of endometrial metastasis into the vagina are presented. Recommendations based on a detailed analysis of isodose distribution versus the applicator type and radiation source used are given. Annular colpostat using 137cesium radiation form the Selectron NMD/SMD installation and 197indium radiation from the MicroSelectron unit produces the maximum mean reference isodose. Uniform distribution of 100 % isodose in exophytic and mixed neoplasms and the best mucosal focus and applicator volume-target volume ratio are obtained

1997-01-01

83

The irradiation tolerance dose of the proximal vagina  

International Nuclear Information System (INIS)

Purpose: The purpose of this investigation was to determine the irradiation tolerance level and complication rates of the proximal vagina to combined external irradiation and low dose rate (LDR) brachytherapy. Also, the mucosal tolerance for fractionated high dose rate (HDR) brachytherapy is further projected based on the biological equivalent dose (BED) of LDR for an acceptable complication rate. Materials and methods: Two hundred seventy-four patients with stages I-IV cervical carcinoma treated with irradiation therapy alone from 1987 to 1997 were retrospectively reviewed for radiation-associated late sequelae of the proximal vagina. All patients received LDR brachytherapy and 95% also received external pelvic irradiation. Follow-up ranged from 15 to 126 months (median, 43 months). The proximal vagina mucosa dose from a single ovoid (single source) or from both ovoids plus the tandem (all sources), together with the external irradiation dose, were used to derive the probability of a complication using the maximum likelihood logistic regression technique. The BED based on the linear-quadratic model was used to compute the corresponding tolerance levels for LDR or HDR brachytherapy. Results: Grades 1 and 2 complications occurred in 10.6% of patients and Grade 3 complications occurred in 3.6%. There were no Grade 4 complications. Complications occurred from 3 to 71 months (median, 7 months) after completion of irradiation, with over 60% occurring in the first year. By logistic regression analysis, both the mucosal dose from a single ovoid or that from all sources, combined with the external irradiation dose, demonstrate a statistically significant fit to the dose response complication curves (both with P=0.016). The single source dose was highly correlated with the all source dose with a cross-correlation coefficient 0.93. The all source dose was approximately 1.4 times the single source dose. Over the LDR brachytherapy dose rate range, the complication rate was relatively stable to small variations of the underlying tumor biological characteristics and the dose rate. The complication rates change approximately an absolute 1% over the range of the alpha-beta ratio (?/?) from 2 to 4 Gy and repair constant (?) of 0.46/h to 0.60/h. The complication rates increased an absolute 2% over the mucosa dose rate from 1.75 to 3.50 Gy/h. They markedly increased as the dose rate increased above 3.00 Gy/h as in HDR brachytherapy. The projected HDR Grade 3 tolerance varied from 25 Gy for one fraction to 57 Gy for six fractions in addition to 20 Gy external irradiation for nominal 3-5% complication rates. The traditional LDR tolerance dose of 150 Gy was shown to yield nominal 11% and 4% Grades 1 and 2 and Grade 3 sequelae, respectively. Conclusions: The traditional 150 Gy LDR tolerance dose (single source plus external irradiation) can be relaxed to 175 Gy or equivalently a full mucosal dose of 238 Gy (all sources plus external irradiation) for a nominal 5% Grade 3 complication rate. Higher fractionation is necessary with four to six fractions in HDR therapy for similar rates of sequelae. The mucosal surface dose from a single ovoid, which can be readily computed, remains a convenient tolerance check for treatment planning purposes

2003-04-01

84

Measuring the space between vagina and rectum as it relates to rectocele  

Digital Repository Infrastructure Vision for European Research (DRIVER)

AIM: To measure the normal space between the posterior wall of the vagina and the anterior wall of the respectively rectum using computed tomography (CT) and reveal its were relationship to rectocele.

Liu, Jin; Zhai, Li-dong; Li, Yun-sheng; Liu, Wan-xiang; Wang, Rui-hua

2009-01-01

85

Carcinoma of vagina 10 or more years following pelvic irradiation therapy  

International Nuclear Information System (INIS)

Gynecologic cancer records of 4,238 patients treated between 1956 and 1974 were reviewed. Sixteen patients developed neoplasia in the cervix or vagina 10 or more years following pelvic irradiation. Three patients had squamous carcinoma in situ; the other 13 patients had invasive squamous cancer involving the upper vagina. Only 1.26 percent of invasive carcinoma of the cervix treated by radiation therapy from 1956 to 1966 presented with a late or recurrent or new primary tumor involving the vagina or cervix 10 or more years after primary treatment. The authors conclude that the risk of developing radiation-induced carcinoma in the upper vagina or cervix following pelvic irradiation is low. Follow-up Pap smears are indicated for all patients treated for cervical or vaginal malignancies by radiation therapy in order to detect vaginal neoplasia as well as recurrent carcinoma of the cervix

1977-03-01

86

[The rare case of erosive lichen planus with large leasions in vulvar area and vagina].  

Science.gov (United States)

The main aim of our paper was to point out the rare localization of erosive lichen planus in vulvar region and vagina. Moreover, these untreated lesions may be the starting point of squamous cell carcinoma. PMID:17477090

Rotsztejn, Helena; Kolasa-Zwierzchowska, Dorota; Krawczyk, Tomasz; Szpakowski, Marian; Kulig, Andrzej

2007-01-01

87

Anatomic and histological characteristics of vagina reconstructed by McIndoe method  

Directory of Open Access Journals (Sweden)

Full Text Available Background/Aim. Congenital absence of vagina is known from ancient times of Greek. According to the literature data, incidence is 1/4 000 to 1/20 000. Treatment of this anomaly includes non-operative and operative procedures. McIndoe procedure uses split skin graft by Thiersch. The aim of this study was to establish anatomic and histological characteristics of vagina reconstructed by McIndoe method in Mayer Küster-Rockitansky Hauser (MKRH syndrome and compare them with normal vagina. Methods. The study included 21 patients of 18 and more years with congenital anomaly known as aplasio vaginae within the Mayer Küster-Rockitansky Hauser syndrome. The patients were operated on by the plastic surgeon using the McIndoe method. The study was a retrospective review of the data from the history of the disease, objective and gynecological examination and cytological analysis of native preparations of vaginal stain (Papanicolau. Comparatively, 21 females of 18 and more years with normal vaginas were also studied. All the subjects were divided into the groups R (reconstructed and C (control and the subgroups according to age up to 30 years (1 R, 1C, from 30 to 50 (2R, 2C, and over 50 (3R, 3C. Statistical data processing was performed by using the Student's t-test and Mann-Writney U-test. A value of p < 0.05 was considered statistically significant. Results. The results show that there are differences in the depth and the wideness of reconstructed vagina, but the obtained values are still in the range of normal ones. Cytological differences between a reconstructed and the normal vagina were found. Conclusion. A reconstructed vagina is smaller than the normal one regarding depth and width, but within the range of normal values. A split skin graft used in the reconstruction, keeps its own cytological, i.e. histological and, so, biological characteristics.

Kozarski Jefta

2009-01-01

88

Tubulo-squamous polyp of the vagina. A case with cellular, "angiomyofibroblastic-like" stroma.  

Science.gov (United States)

Tubulo-squamous polyp is an infrequent, apparently benign lesion which has recently been described in the vagina. Histologically, it is characterized by an epithelial component, consisting of squamous nests and tubules, embedded in a hypocellular fibrous stroma. Here, we report an unusual histological variant showing a cellular stroma, as an additional histologic feature, which could lead to confusion with other site-specific lesions of the vagina. A brief review of the literature on this entity is also provided. PMID:22799055

Vassallo, L; Lio, R; Vestri, M; Miracco, C

2012-02-01

89

Results of radiation therapy of squamous cell carcinoma of vagina  

International Nuclear Information System (INIS)

Over a period from 1962 to 1982, 31 patients with squamous cell carcinoma in the vagina were treated by irradiation at National Cancer Center Hospital, Tokyo. Of them, 15 patients (48.4%) were over 60 years old. Treatment was done by external irradiation alone or a combination of external and intracavitary or interstitial irradiation. The lesions were classified into stages of the FIGO system. Stage I was found in 11 cases (35.5%), Stage II in 11 cases (35.5%), Stage III in 7 cases (22.6%) and Stage IVa in 1 case (3.2%). Serious complication after treatment was observed in 5 cases (16.1%) which consisted of 2 cases of rectovaginal fistula and one case of rectal constriction, one case of intestinal necrosis and one case of rectal ulcer. Local and pelvic failure was noted in 6 cases (19.4%) which were treated by reirradiation. Prognosis was poor in all cases, except one which was in Stage I. Some subsequent surgical procedures were required for further treatment in those cases. The 5-year survival rates by stage were as follows: 90% (9/10) for cases of Stage I, 22.2% (2/9) for cases of Stage II, 16.7% (1/6) for cases of Stage III and 0% (0/1) for case of Stage IVa. (author)

1984-01-01

90

Congenital absence of the vagina with a functioning uterus  

International Nuclear Information System (INIS)

A functioning uterus may be present in 5 to 10 % of the patients with congenital absence of the vagina. The proper treatment for these patients depends on accurate pre-operative diagnosis on whether or not a cervix is present, because the mode of operation should be selected according to the type of abnormality. Ultrasonography or X-ray CT scan will not always be useful to answer this question. We encountered a 15-year-old female with cyclic lower abdominal pain and the failure of onset of menstruation. The external genitalia were normal except for the absence of the vaginal opening. Ultrasonography and X-ray CT scan revealed the presence of both uterine corpus and hematocolpos, but no definite findings were obtained on the integrity of the cervix. By using NMR-CT scan, we found a hematocolpos, properly developed uterine cervix and corpus above it. We treated the patient by preserving the uterine function and the potential for pregnancy in the future. NMR-CT scan seems more useful in some cases for diagnosis of pelvic mass than ultrasonography and X-ray CT scan. (author)

1986-01-01

91

Normal bacterial flora from vaginas of Criollo Limonero cows.  

Science.gov (United States)

In order to describe the normal bacterial flora in vaginas of Criollo Limonero cows, 51 healthy multiparous cows, at least 90-day postpartum, were selected. Duplicated swabs (N = 102) were taken from the vaginal fornix of cows to perform aerobic and anaerobic cultures as well as conventional biochemical tests. Out of 102 swabs, bacterial growth was obtained in 55 (53.9%) while the remaining 47 (46.1%) did not exhibited any bacterial growth. Of the 55 bacterial growths, 23 (41.8%) were aerobic whereas 32 (58.1%) were anaerobic. Likewise, 29 (52.72%) of bacterial growths were pure and 26 (47.27%) were mixed. Under both aerobic and anaerobic conditions, Gram positive bacteria were predominant (81.82% and 73.08%, respectively) over Gram negative bacteria (18.18% and 26.92%, respectively). Isolated bacteria were Arcanobacterium pyogenes (22.92%), Staphylococcus aureus (15.63%), Staphylococcus coagulase negative (17.71%), Erysipelothrix rhusiopathiae (6.25%), Bacteroides spp. (13.54%), and Peptostreptococcus spp. (7.29%). In conclusion, normal vaginal bacterial flora of Criollo Limonero cows was predominantly Gram positive and included A. pyogenes, S. aureus, coagulase negative Staphylococcus, E. rhusiopathiae, Bacteroides spp., and Peptostreptococcus spp. In Criollo Limonero cattle, adaptive aspects such as development of humoral and physical mechanisms for defense, and bacterial adaptation to host deserve research attention. PMID:21082249

Zambrano-Nava, Sunny; Boscán-Ocando, Julio; Nava, Jexenia

2011-02-01

92

Contrast vaginography is more accurate than the radiopaque rod for localization of the vagina  

International Nuclear Information System (INIS)

Purpose: To compare the radiopaque vaginal rod method with contrast vaginography in localization of the vagina. Methods and Materials: In 25 female patients who needed pelvic radiotherapy, both our standard localization procedure using the vaginal rod and a localization procedure using contrast vaginography were performed. As a rod can change the position of the vagina, contrast vaginography was considered to display the true anatomic position of the vagina. The corresponding rod and nonrod X-rays of each patient were compared. The distance from the true vaginal apex to the displaced vaginal apex (= the top of the rod) was measured in the sagittal plane. This distance was called the inaccuracy of the rod method. Furthermore, the size of the vaginal vault was measured using the contrast vaginography. Results: The median inaccuracy of the rod method was 13 mm (range 2 to 24 mm). The maximal width of the vagina ranged from 24 to 68 mm in the frontal plane (median 39 mm) and from 3 to 22 mm in the sagittal plane (median 10 mm). Conclusion: The rod method is not accurate to localize the vagina. Furthermore, the rod gives no information on the actual size of the vaginal vault. Contrast vaginography is the method of choice to localize the vagina.

2000-12-01

93

Exclusive radiotherapy for primary squamous cell carcinoma of the vagina  

International Nuclear Information System (INIS)

Purpose: To retrospectively analyze results of external beam therapy (EBT) with brachytherapy (BT) for primary vaginal squamous cell carcinoma (PVSCC). Materials and methods: From 1970 to 2001, 91 patients were included. FIGO stages were: I (29%), II (38%), III (29%) and IVa (4%). EBT delivered a median total dose of 50 Gy to the pelvis. BT was performed with a customized intra-vaginal applicator and in 36% of applications combined endocavitary and interstitial BT. ICRU Report 38 parameters were reported. Results: The 5-year cause specific survival (CSS) rates were: 83% for stage I, 76% for stage II, 52% for stage III, and 2 of the 4 stage IVa patients died 9 and 36 months after treatment. The 5-year pelvis control rates were: 79% for stage I and II and 62% for stage III. Recurrences as a first event were local only in 68% of cases, nodal only in 10%, metastatic only in 13% and combined in 9%. In multivariate analysis: stage (I and II versus II and IV), response to EBT (evaluated at BT), and the number of BT applications were statistically significant for CSS. Grade 2-3 toxicities were as follows (Franco-Italian Glossary): rectum (n = 3), sigmoid colon and small bowel (n = 8), bladder (n = 5), ureter (n = 4) and vagina (n = 13). Anterior location of the tumor increased bladder toxicity (p = 0.01) and total reference air kerma was higher in patients who experienced grade 2-3 urinary or digestive toxicity (p = 0.03). Conclusion: EBT with BT is an effective treatment for patients with stage I-II PVSCC. The incidence and severity of late toxicity were relatively low. Recent advances in the treatment of cervix carcinoma emphasize the need for concomitant radio-chemotherapy in stages III-IV and the use of MRI for treatment planning

2007-12-01

94

LASER EN EL TRATAMIENTO DE LA NEOPLASIA INTRAEPITELIAL DE VAGINA  

Directory of Open Access Journals (Sweden)

Full Text Available Objetivo: Presentar la experiencia en el tratamiento de la neoplasia intraepitelial de vagina (VAIN utilizando el láser de CO2. Método: 19 pacientes con el diagnóstico histológico de VAIN fueron tratadas con esta técnica. Se utilizó un diámetro del punto de helio-neón de 1,5 a 2 mm y un poder de densidad de 400 a 500 W/cm². Toda la lesión detectable más un margen de al menos 5 mm de tejido circundante aparentemente normal fueron vaporizados a una profundidad de 2 mm. Resultados: 12 de las 14 pacientes evaluables lograron una respuesta completa inicial (86%, de éstas 12 hubo 2 recidivas posteriores (17%, obteniendo una curación en 10 de las 14 evaluables (71%. No hubo complicaciones y se preservó una función vaginal normal. Conclusión: La vaporización con láser es una buena modalidad terapéutica en VAIN, particularmente en mujeres jóvenes en que se ha descartado razonablemente la coexistencia de cáncer invasorObjective: To describe our experience in the treatment of vaginal intra-epithelial neoplasia (VAIN with the use of CO2 laser. Method: Nineteen patients with the diagnosis of VAIN were treated by this technique. We used a spot size of 1.5 to 2 mm and a power density of 400 to 500 W/cm². The entire lesion in addition to at least a 5 mm margin of adjacent tissue were vaporized to a depth of 2 mm. Results: 12 of 14 evaluable patients had an initial complete response (86%, of these 12, there were 2 recurrences (17%, obtaining a 71% cure rate (10/14. There were no complications and preservation of normal vaginal function. Conclusion: Laser vaporization is a very good treatment modality, particularly in young women in whom the co-existence of invasive malignancy has been ruled out

Roberto Yazigi I

2006-01-01

95

Primary carcinoma of the vagina: Tata Memorial Hospital experience  

International Nuclear Information System (INIS)

Purpose: Carcinoma of the vagina is a rare gynecological malignancy comprising approximately 2% of all the gynecological malignancies. We have analyzed the treatment outcome of the patients treated at the Tata Memorial Hospital from January 1984 to December 1993. Methods and Materials: In this 10-year period, 134 patients of primary vaginal cancers were registered at our hospital. Of these, 75 patients received complete treatment and are analyzed. Results: Disease-free survival (DFS) for the whole group is 50%, and overall survival (OAS) is 60%. Most locoregional recurrences and distant failures are noted in the 2 years following treatment. DFS at 5 years is as follows: Stage I (5 patients), Stage IIA (37 patients), Stage IIB (15 patients), Stage III (14 patients), and Stage IV (4 patients); are 40%, 55%, 60%, 50%, and 25%, respectively. The DFS for patients with complete response (42 patients) to external radiation at 5 years is 68%, with partial response (25 patients) is 35%, and with poor or no response (6 patients) is 18% (p 0.0000). We observed that brachytherapy was an important part of the treatment, and patients who received brachytherapy (59 patients), either with a vaginal intracavitary applicator (30 patients) or interstitial implant (29 patients) had a DFS of 53% and 56%, respectively, while 15 patients who received external radiation alone had a DFS of 30%. Patients receiving brachytherapy within 4 weeks of external radiation had a DFS of 60% as compared to 30% when the interval was more than 4 weeks. Conclusion: The factors indicating prognosis are: site and extent of involvement, presence of lymph nodes at presentation, technique of brachytherapy, and interval between external radiation and brachytherapy

2000-01-01

96

Colocolpopoiesis : the use of sigmoid colon in the treatment of conditions associated with absence of the vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The creation of a coitally functional vagina is an important part of sexual rehabilitation in patients with congenital or acqnired absence of the vagina, and in male-to-female transsexuals. Various conservative and surgical techniques have been developed to construct an artificial vagina. Most of the operative techniques were based on the dissection of a cavity between the bladder and the recrum with subsequent grafting of various materials onto the walls of the 1llnnel. Nowada...

Freundt, I.

1994-01-01

97

Submucosal uterine fibroid prolapsed into vagina in a symptomatic patient with IUS.  

Science.gov (United States)

A female patient in her mid 40s presents with heavy menstrual bleeding (HMB) and a history of spotting/irregular light per vagina (PV) bleeding since intrauterine system (IUS) insertion 1 year ago. She is known to have submucosal uterine fibroid (SMUF). The patient reported abdominal pain and sudden onset of 'miscarriage-like' HMB with clots 2 days ago. On speculum examination there was a smooth round-shaped mass lying over the external cervical os. On bimanual examination PV, a round-shaped smooth mass of a walnut's size was palpable in the upper third of the vagina. Subsequent ultrasound imaging revealed an SMUF prolapsed into the vagina. Further surgical treatment was undertaken. Histology showed a fibroid (leiomyoma) with no evidence of malignancy. PMID:24739657

Matytsina-Quinlan, Lyubov; Matytsina, Laura

2014-01-01

98

Endodermal sinus tumor of the vagina in children: A report of two cases  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant tumors of the vagina in infants and children are rare, with primary germ cell tumor (endodermal sinus tumor [EST] being rarer, which carries a dismal prognosis. This tumor is often clinically mistaken as botryoid rhabdomyosarcoma and, on histopathological examination, is often misdiagnosed as clear cell adenocarcinoma. Two cases of EST of the vagina in infants aged 9 and 17 months are reported. Both the patients presented with bleeding per vagina and clinically and by ultrasonography were diagnosed as sarcoma botryoides. Both were diagnosed as primary yolk sac tumors. The serum alfa fetoprotein (AFP level was 4325 and 9328 ng/ml, respectively. One patient aged 9 months expired 2 months after receiving chemotherapy. The other, aged 17 months, was given chemotherapy followed by surgery with reduction of the AFP levels.

Gangopadhyay Mimi

2009-07-01

99

ALMACENAMIENTO DE ESPERMATOZOIDES EN LA VAGINA DE LA LAGARTIJA VIVÍPARA SCELOPORUS TORQUATUS (SAURIA: PRHYNOSOMATIDAE  

Directory of Open Access Journals (Sweden)

Full Text Available Las hembras de muchas especies de lagartijas tienen la capacidad de almacenar espermatozoides en un sistema de túbulos especiales presentes en la vagina. Sin embargo, en otras especies los espermatozoides se almacenan en el infundíbulo. Se utilizó una técnica sencilla y rápida para determinar sí la vagina de Sceloporus torquatus tiene la capacidad de almacenar espermatozoides. En las hembras de esta especie, los espermatozoides son retenidos al menos 167 días en un sistema de túbulos especiales localizados en la vagina. La cantidad de espermatozoides presentes en los lavados vaginales disminuyó gradualmente a partir de diciembre y su desaparición ocurrió en la preñez tardía. Los espermatozoides ascienden al útero e infundíbulo antes de que ocurra la ovulación, sin embargo, en estos órganos no existen estructuras especiales para almacenar espermatozoides.

Martín MARTÍNEZ-TORRES

2009-01-01

100

Using a vaginal tube to separate the uterus from the vagina during laparoscopic hysterectomy.  

Science.gov (United States)

Hysterectomy performed totally by laparoscopy has few advocates because separating the cervix from the vagina is difficult. This technical difficulty can be overcome by placing a wide-bore plastic tube in the vagina to expose the cervico-vaginal junction and stretch the vaginal fornices. The stretched vagina falls away from the cervix as diathermy cuts over the tube rim. The tube guides the incision, and the plastic protects any adjacent structures. The most convenient external diameter is between 4-5 cm. Made from smooth, electrically-inert plastic, the tube's opposite distal end has a valve that maintains the pneumoperitoneum. We have used it in 73 cases, and the only associated complication has been one vault pelvic hematoma. PMID:7824248

McCartney, A J; Johnson, N

1995-02-01

 
 
 
 
101

Imaging of the vagina and vulva; Aspectos de imagem das lesoes vulvo-vaginais  

Energy Technology Data Exchange (ETDEWEB)

In gynecological daily practices, the vulva and vagina are examined during physical examination, however there are situations where this is not possible or it is needed to determine the extension of an injury through imaging methods. The magnetic resonance imaging is an excellent cross-sectional modality for evaluation the alterations of vulva and vagina due its multiplanar evaluation and high tecidual contrast. Other cross-sectional modalities are ultrasound and enhanced computed tomography. This paper intends to give an overview of vaginal and vulvar pathology that can be identified by the radiologist. (author)

Souza, Luis Ronan Marquez Ferreira de; Szejnfeld, Jacob [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. de Diagnostico por Imagem]. E-mail: luisronan@gmail.com; Borges, Leonardo Romualdo; Rosalen Junior, Roberto Antonio [Universidade Federal do Triangulo Mineiro (UFTM), Uberaba, MG (Brazil); Signorini Filho, Roney Cesar; Marques, Renato Moretti; Nicolau, Sergio Mancini [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Disciplina de Oncoginecologia; Goldman, Suzan Menasce [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. de Diagnostico por Imagem

2006-10-15

102

Carcinoma of the vulva and vagina in patients irradiated for carcinoma of the cervix  

International Nuclear Information System (INIS)

Six patients with carcinoma of the vulva and 3 with carcinoma of the vagina following radiation therapy for cancer of the cervix were analyzed. The interval between irradiation and diagnosis of the second tumor varied from 5 to 23 years. Despite the lack of having detailed information on irradiation factors in all patients, circumstantial evidence from this study suggests that radiation therapy may have contributed to the development of carcinoma of the vulva and vagina in some of the patients. Close follow-up patients treated for squamous carcinoma of the genital tract must emphasize inspection for new lesions. The incidences previously reported in the literature are also reviewed for comparison. (author)

1984-01-01

103

Cytological Diagnosis of Small Cell Carcinoma of Vagina - A Diagnostic Dilemma  

Directory of Open Access Journals (Sweden)

Full Text Available Small cell carcinoma is a neuroendocrine tumour, mainly arises in lung accounting for 20%of cases. In extra pulmonary sites it accounts for 5% of cases. Among gynaecological malignancies it accounts for 1-2% of cases, common sites are cervix, endometrium, ovary, vagina, vulva in decreasing frequencies. Small cell carcinoma is extremely uncommon in vagina.There are only 26 cases reported in the literature. Here we are reporting 27 th case. Because of its rarity the chances of missing the diagnosis are more. Correct morphological identification, with immunohistochemical analysis is essential for definitive diagnosis which will be helpful in planning appropriate treatment.

B. R. Yelikar

2013-01-01

104

Non-Diethylstilbestrol-Associated Primary Clear Cell Carcinoma of the Vagina: Two Case Reports with Immunohistochemical Studies and Literature Review  

Science.gov (United States)

Primary clear cell adenocarcinomas most commonly involve the genitourinary system, including the vagina. Previously, primary clear cell adenocarcinomas of the vagina have been discussed within the context of prenatal exposure to diethylstilbestrol. Due to its widely proven role in the development of this carcinoma, administration of diethylstilbestrol is prohibited. We present two cases of non-diethylstilbestrol-associated primary clear cell adenocarcinoma of the vagina from the archives of the Anatomical Pathology Department at King Abdulaziz University in order to improve our understanding of its biological behavior. Our findings suggest that primary clear cell adenocarcinoma of the vagina may be unrelated to diethylstilbestrol exposure and that non-diethylstilbestrol-associated primary clear cell adenocarcinoma of the vagina, when present at a younger age, may have a worse prognosis.

Mufti, Shagufta T.; Ali, Hiba Hassan

2014-01-01

105

Non-diethylstilbestrol-associated primary clear cell carcinoma of the vagina: two case reports with immunohistochemical studies and literature review.  

Science.gov (United States)

Primary clear cell adenocarcinomas most commonly involve the genitourinary system, including the vagina. Previously, primary clear cell adenocarcinomas of the vagina have been discussed within the context of prenatal exposure to diethylstilbestrol. Due to its widely proven role in the development of this carcinoma, administration of diethylstilbestrol is prohibited. We present two cases of non-diethylstilbestrol-associated primary clear cell adenocarcinoma of the vagina from the archives of the Anatomical Pathology Department at King Abdulaziz University in order to improve our understanding of its biological behavior. Our findings suggest that primary clear cell adenocarcinoma of the vagina may be unrelated to diethylstilbestrol exposure and that non-diethylstilbestrol-associated primary clear cell adenocarcinoma of the vagina, when present at a younger age, may have a worse prognosis. PMID:24850989

Mufti, Shagufta T; Ali, Hiba Hassan

2014-05-01

106

Melanoma amelanótico primario de vagina: reporte de un caso y revisión de la literatura Primary amelanotic melanoma of the vagina: a case report and literature review  

Directory of Open Access Journals (Sweden)

Full Text Available Objetivo: revisar el diagnóstico clínico, histológico e inmunohistoquímico; las alternativas terapéuticas y los factores que influyen en el pronóstico del melanoma amelanocítico de vagina. Materiales y métodos: se presenta el caso de una paciente de 49 años que consultó por masa vaginal de 8 cm en pared anterior de vagina, nacarada y con fondo necrótico a la Unidad de Patología Cervical y Colposcopia del Hospital de Engativá, institución de segundo nivel de complejidad que atiende pacientes de nivel socioeconómico bajo afiliados al régimen de seguridad pública. Se realizó resección amplia de la lesión. La patología quirúrgica informó melanoma fusocelular y epiteloide maligno. Se realizó una búsqueda sistemática usando las palabras clave: melanoma primario y vagina en las bases de datos Medline vía PubMed, Cochrane y Ebsco. Resultados: se encontraron 489 artículos de los cuales 31 estaban relacionados directamente con el tema, de estos se seleccionaron diez que correspondieron a nueve reportes de caso y a una revisión del tema. El diagnóstico clínico no es fácil. Las proteínas HMB45 y S100 son de gran utilidad en su identificación. La respuesta al tratamiento quirúrgico, la radioterapia y la quimioterapia es pobre. El pronóstico depende de la ploidía, la amelanosis y el índice mitótico. Conclusiones: el melanoma primario de vagina es una neoplasia rara y de mal pronóstico. Hace parte del grupo de melanomas de mucosa que tienen un origen y comportamiento biológico diferente al cutáneo. Tiene tendencia a la diseminación hematógena rápida y a recaídas locales. El tratamiento se basa en cirugía conservadora, radioterapia, quimioterapia y terapia biológica; sin embargo, su eficacia es limitada.Objective: reviewing clinical, histological and immunohistochemical diagnosis, therapeutic alternatives and factors influencing prognosis for amelanotic melanoma of the vagina. Materials and methods: this article presents the case of a 49yearold patient who consulted the Engativá Hospital’s Cervical Pathology and Colposcopy Unit due to an 8 cm diameter necrotic pearlywhite vaginal mass on the anterior vaginal wall. The hospital is a secondary level complexity institution dealing with low socioeconomic level patients affiliated to the public (subsidized social security (health system. A broad resection was made of the lesion. Surgical pathology revealed epithelioid fusocellular malignant melanoma. A systematic literature search was made using the following key words: primary melanoma and vagina in Medline databases via Pub Med, Cochrane and Ebsco. Results: 31 of the 489 articles found were directly related to the topic; 10 new case reports and a review were selected. Clinical diagnosis is not easy; HMB45 and S100 proteins are extremely useful in identifying it.Response to surgical treatment, radiotherapy and chemotherapy is poor. Prognosis depends on ploidy, amelanosis and mitotic index. Conclusions: Primary melanoma of the vagina is a rare neoplasm and has a poor prognosis. It forms part of a group of mucosal melanoma having an origin and biological behavior different to that of cutaneous melanoma. It tends to have rapid hematogenous dissemination and local relapses. Treatment is based on conservative surgery, radiotherapy, chemotherapy and biological therapy; however, its effectiveness is limited.

María Paula Houghton-Martínez

2012-03-01

107

Melanoma amelanótico primario de vagina: reporte de un caso y revisión de la literatura / Primary amelanotic melanoma of the vagina: a case report and literature review  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Objetivo: revisar el diagnóstico clínico, histológico e inmunohistoquímico; las alternativas terapéuticas y los factores que influyen en el pronóstico del melanoma amelanocítico de vagina. Materiales y métodos: se presenta el caso de una paciente de 49 años que consultó por masa vaginal de 8 cm en p [...] ared anterior de vagina, nacarada y con fondo necrótico a la Unidad de Patología Cervical y Colposcopia del Hospital de Engativá, institución de segundo nivel de complejidad que atiende pacientes de nivel socioeconómico bajo afiliados al régimen de seguridad pública. Se realizó resección amplia de la lesión. La patología quirúrgica informó melanoma fusocelular y epiteloide maligno. Se realizó una búsqueda sistemática usando las palabras clave: melanoma primario y vagina en las bases de datos Medline vía PubMed, Cochrane y Ebsco. Resultados: se encontraron 489 artículos de los cuales 31 estaban relacionados directamente con el tema, de estos se seleccionaron diez que correspondieron a nueve reportes de caso y a una revisión del tema. El diagnóstico clínico no es fácil. Las proteínas HMB45 y S100 son de gran utilidad en su identificación. La respuesta al tratamiento quirúrgico, la radioterapia y la quimioterapia es pobre. El pronóstico depende de la ploidía, la amelanosis y el índice mitótico. Conclusiones: el melanoma primario de vagina es una neoplasia rara y de mal pronóstico. Hace parte del grupo de melanomas de mucosa que tienen un origen y comportamiento biológico diferente al cutáneo. Tiene tendencia a la diseminación hematógena rápida y a recaídas locales. El tratamiento se basa en cirugía conservadora, radioterapia, quimioterapia y terapia biológica; sin embargo, su eficacia es limitada. Abstract in english Objective: reviewing clinical, histological and immunohistochemical diagnosis, therapeutic alternatives and factors influencing prognosis for amelanotic melanoma of the vagina. Materials and methods: this article presents the case of a 49yearold patient who consulted the Engativá Hospital’s Ce [...] rvical Pathology and Colposcopy Unit due to an 8 cm diameter necrotic pearlywhite vaginal mass on the anterior vaginal wall. The hospital is a secondary level complexity institution dealing with low socioeconomic level patients affiliated to the public (subsidized) social security (health) system. A broad resection was made of the lesion. Surgical pathology revealed epithelioid fusocellular malignant melanoma. A systematic literature search was made using the following key words: primary melanoma and vagina in Medline databases via Pub Med, Cochrane and Ebsco. Results: 31 of the 489 articles found were directly related to the topic; 10 new case reports and a review were selected. Clinical diagnosis is not easy; HMB45 and S100 proteins are extremely useful in identifying it.Response to surgical treatment, radiotherapy and chemotherapy is poor. Prognosis depends on ploidy, amelanosis and mitotic index. Conclusions: Primary melanoma of the vagina is a rare neoplasm and has a poor prognosis. It forms part of a group of mucosal melanoma having an origin and biological behavior different to that of cutaneous melanoma. It tends to have rapid hematogenous dissemination and local relapses. Treatment is based on conservative surgery, radiotherapy, chemotherapy and biological therapy; however, its effectiveness is limited.

Houghton-Martínez, María Paula; Amaya-Guío, Jairo; Díaz-Cruz, Luz Amparo.

108

Histologische und molekularbiologische Untersuchungen zur Pathogenese des Prolapsus vaginae ante partum beim Schaf  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Der Prolapsus vaginae ante partum (a.p.) ist ein seit langem bekanntes Krankheitsbild bei Schafen im letzten Drittel der Gravidität. Trotz umfangreicher Forschung konnte bisher keine befriedigende Erklärung der speziespezifisch signifikanten Häufung dieser antepartalen Störung gegeben werden.Ziel dieser Studie war es deshalb, neben der Überprüfung der Elektrolythomöostase und der endokrinologischen Situation weitere Erklärungsansätze der Pathogenese des ovinen Vaginalprolaps a.p....

2004-01-01

109

Changes in germ cells population and in vitro oocyte maturation in female mice with imperforated vagina.  

Science.gov (United States)

This study characterized female mice with a congenital defect in their reproductive tract. In females derived from an outbred colony maintained in the Department of Genetics and Evolution, the frequency of the imperforated vaginae was approximately 2%. A consequence of this defect is infertility. Affected animals developed hydrometrocolpos (the uterus and vagina were greatly distended by fluid). Morphology of the ovary and oviduct was normal and similar to that of control mice. In the females with an imperforated vagina numerous corpora lutea were observed. Accordingly, we have found that both spontaneous as well as exogenous gonadotrophin-induced ovulation occurs in such females. Nevertheless, oocytes derived from ovaries of occluded females exhibited a partial block during in vitro maturation. Histological analysis of ovarian tissue revealed an increase in the number of primary follicles (type I follicles) and a decrease in the number of secondary and antral follicles (type IV and type VI follicles) when compared with control mice. The concentration of androgens in the ovarian tissue was higher in the affected females. Our data show that females with an imperforated vagina can be a useful model for studying the mechanism of genetic control of the development of the urogenital tract in mammals. PMID:18412125

Lenartowicz, Ma?gorzata; Brzek, Barbara; Pola?ski, Zbigniew; Sierpniowska, Aleksandra; Galas, Jerzy; Bili?ska, Barbara

2008-06-01

110

Nevoid melanoma of the vagina: report of one case diagnosed on thin layer cytological preparations  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Primary melanoma of the vagina is an extremely rare neoplasm with approximately 250 reported cases in the world literature 1234. In its amelanotic variant this lesion may raise several differential diagnostic problems in cytological specimens 5. In this setting, the usage of thin layer cytopathological techniqu...

Fulciniti Franco; Ascierto Paolo; Simeone Ester; Bove Patrizia; Losito Simona; Russo Serena; Gallo Maria; Greggi Stefano

2007-01-01

111

Clinical evaluation of the effectiveness of radiotherapy for cervical carcinoma disseminated to the vagina  

International Nuclear Information System (INIS)

The study presents an analysis of the data on 137 patients with cervical carcinoma metastases to the vagina (CCMV) treated with both combined (distance + contact) radiation and contact radiation alone administered in low, medium and high dose. It is shown that there was no correlation between radiotherapy efficacy and regimen (surgery, combined therapy or radiation) in the management of primary cervical carcinoma

1998-01-01

112

Detection of Atopobium vaginae in Postmenopausal Women by Cultivation-Independent Methods Warrants Further Investigation  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We sequenced 16S rRNA genes from the vaginal swab contents of a postmenopausal woman with asymptomatic bacterial vaginosis (BV). Sequences from Atopobium vaginae were the most commonly detected. In a survey of 35 other postmenopausal women, this organism was detected in 44% with BV but not in any subjects deemed healthy.

Burton, Jeremy P.; Devillard, Estelle; Cadieux, Peter A.; Hammond, Jo-anne; Reid, Gregor

2004-01-01

113

Mioepitelioma de vagina: neoplasia poco frecuente en esta localización, reporte de un caso  

Directory of Open Access Journals (Sweden)

Full Text Available Antecedentes: Los mioepiteliomas, son tumores poco frecuentes originados a partir de la proliferación de células mioepiteliales. La mayor parte localizados en las extremidades inferiores y en glándulas salivales. Existen ocasionales informes previos de MEP que involucren la vagina. Objetivo: Describir un caso de mioepitelioma localizado en vagina. Caso clínico: Embarazada de 29 años edad, quien presenta una masa vaginal de un año de evolución, localizada en el himen. El examen histopatológico muestra una lesión compuesta por células fusiformes con positividad inmunohistoquímica para vimentina, citoqueratinas (CK AE1/ AE3, S100, CD10, receptores de estrógenos y progesterona, Bcl2 y calponina y negatividad para desmina, actina muscular especifica, actina de músculo liso y p63. Con los anteriores hallazgos se interpreta la lesión como un mioepitelioma primario vaginal. Conclusión: Los mioepiteliomas son tumores que requieren para su diagnostico, análisis con técnicas de inmunohistoquímica o ultraestructurales que permitan diferenciarlos de otros tumores.Background: The myoepitheliomas are rare tumors arising from the proliferation of myoepithelial cells. Most tumors are located in the lower extremity and salivary glands. There have been only occasional myoepithelial neoplasms previously reported involving the vagina. Objective: Describe a case of myoepithelioma located in the vagina of a pregnant woman. Case report: A 29 years old pregnant female, who about 1 year prior has a vaginal mass, located in the hymen. At histopathological examination shows a mass composed of spindle cells with positivity immunohistochemical studies for vimentin, cytokeratin AE1/AE3, S100, CD10 and calponin and negative for desmin, actinmuscle specific (HHF35, smooth muscle actin and p63. With these findings it was established the diagnosis of myoepithelioma in the vagina. Conclusion: Myoepitheliomas are tumors requiring for diagnostic of immunohistochemistry or ultrastructural techniques that allow its differentiation from other tumors.

Alfredo Romero R

2012-01-01

114

The oophorectomy effect on Walker 256 tumor inoculated into the vagina and uterine cervix of female rats Efeito da ooforectomia no tumor de Walker 256 inoculado em vagina e colo de útero de ratos fêmeas  

Digital Repository Infrastructure Vision for European Research (DRIVER)

PURPOSE: Verify the effect of oophorectomy on the evolution of the Walker 256 tumor inoculated into the vagina and cervix of female rats. METHODS: Ten Wistar, female rats were used, distributed into two groups with 05 animals each: Tumor group (TG): Rats inoculated with Walker 256 tumor; Oophorectomy group (OG): oophorectomized rats inoculated with Walker 256 tumor. The day before the tumor vaginal inoculation, acetic acid was inoculated into the vaginas of both groups of rats; the following ...

Nara Macedo Botelho Brito; Rita de Kássia Vidigal Carvalho; Lia Tavares de Moura Brasil Matos; Rodolfo Costa Lobato; Rosângela Baía Brito

2009-01-01

115

Primary carcinoma of the vagina: A study of a Radiumhemmet series of 145 cases  

International Nuclear Information System (INIS)

The infrequency of carcinoma of the vagina and the concomitant paucity of cases treated at any one institution have long delayed an appreciation of the fundamental characteristics of this disease and hindered the development of an effective programme of management. In the past decade publications based on relatively large number of cases have appeared from several clinics. These have greatly augmented previous reports of this disorder. However, the lack of a uniform clinical classification regarding the extent of the disease process before treatment has invalidated any attempt to compare the efficacy of methods of therapy employed at different clinics. It is the purpose of this paper to suggest a clinical classification for carcinoma of the vagina and to evaluate the cases treated at the Radiumhemmet in accordance with this proposed staging

1984-01-01

116

Difference in signalling between various hormone therapies in endometrium, myometrium and upper part of the vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

BACKGROUND: Combined hormone treatments in post-menopausal women have different clinical responses on uterus and vagina; therefore, we investigated differences in steroid signalling between various hormone therapies in these tissues. METHODS: A total of 30 post-menopausal women scheduled for hysterectomy were distributed into four subgroups: control-group (n = 9), Tibolone-group (n = 8); estradiol (E(2))-group (n = 7); E(2) + medroxyprogesterone acetate (MPA)-group (n = 6). Medication was adm...

Hanifi-moghaddam, P.; Boers-sijmons, B.; Klaassens, A. H. A.; Wijk, F. H.; Ijcken, W. F. J.; Spek, P. J.; Verheul, H. A. M.; Kloosterboer, H. J.; Burger, C. W.; Blok, L. J.

2008-01-01

117

Magnetic resonance imaging features of myxoid leiomyoma of the vagina: A case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We report a rare case of a voluminous vaginal myxoid leiomyoma in a 27-year-old nulliparous woman. Magnetic Resonance Imaging (MRI) revealed a mass arising from the vagina, with inhomogeneous signal intensity on spin-echo T1W and T2W images. MRI accurately defined the tissue planes between the lesion and the adjacent structures and suggested its benign nature. The mass was completely resected by means of transvaginal approach and the diagnosis of myxoid leiomyoma was confirmed histologically....

Scialpi, Michele; Benagiano, Giuseppe; Frati, Sara; Piscioli, Irene; Barberini, Francesco; Lupattelli, Luciano

2009-01-01

118

A simple, inexpensive applicator for irradiation of localized areas of the vagina with intracavitary brachytherapy  

International Nuclear Information System (INIS)

Purpose: To describe the construction of a simple, inexpensive applicator for irradiation of localized areas of the vagina with intracavitary brachytherapy Methods and Materials: It was desirable to avoid an interstitial implant in an elderly patient with a stage T2 vaginal cancer. The final phase of radiation therapy was delivered with a custom made intracavitary cylinder that allowed the high-dose area to be limited to the portion of the vagina at high risk for residual disease. The applicator was fabricated from a clear cast acrylic (Lucite) rod with dimensions 3.5 cm diameter x 5.0 cm long. The applicator contained 11 parallel grooves, each 1.8 mm deep x 2.2 mm wide, machined along the surface of the cylinder parallel its long axis at 1.0 cm increments. Plastic needles (15 gauge) were inserted into the grooves along the surface of the acrylic cylinder and held in place with heat shrink tubing. The applicator was easily inserted and positioned without anesthesia. Standard low dose rate 192Ir ribbons were inserted into the plastic needles after positioning the applicator in the vagina. Results: Construction of this applicator system requires a few weeks notice and approximately $150. Fabrication of the grooved cylinder is a routine task for a workshop with a milling machine. A step-by-step description of how to construct and use the applicator is provided along with the telephone numbers of commercial vendors to call to order all necessary materials. Conclusion: This article describes a simple, inexpensive method for constructing a customized vaginal applicator that can be used to treat a limited area of the vagina with intracavitary brachytherapy

1997-03-01

119

Recurrent Fistula between Ileal Pouch and Vagina—Successful Treatment with a Gracilis Muscle Flap  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fistulae between an ileal pouch and the vagina are an uncommon complication of ileal pouch-anal anastomosis following proctocolectomy and mucosectomy in patients with familial adenomatous polyposis coli. Several reports describe the successful use of muscle flaps to close recurrent pouch-vaginal-fistulae (PVF). However, series only contain small numbers and an optimal management has not yet been determined. We report the case of a 26-year old woman with a third recurrence of a PVF after proct...

2009-01-01

120

Survival of gram positive anaerobic cocci on swabs and their isolation from the mouth and vagina.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The survival of Gram positive anaerobic cocci on plain cotton wool and albumin coated swabs held in various transport media was investigated. Results suggested that in most cases Amies', Stuart's and VMGII media do not offer any more protection to the bacteria than storing swabs dry in their containers. A technique was developed for the isolation and identification of Gram positive anaerobic cocci from the mouth and vagina, incorporating bicozamycin in the medium as a selective agent. Few str...

1986-01-01

 
 
 
 
121

Measuring the space between vagina and rectum as it relates to rectocele  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To measure the normal space between the posterior wall of the vagina and the anterior wall of the respectively rectum using computed tomography (CT and reveal its were relationship to rectocele.METHODS: A total of twenty female volunteers without rectocele were examined by CT scan. We performed a middle level continuous horizontal pelvic scan from the upper part to the lower part and collected the measurement data to analyze the results using t-test.RESULTS: Twenty volunteers were enrolled in the study. The space between the posterior wall of the vagina and the anterior wall of the rectum was measured at three levels (upper 1/3, middle, lower 1/3 level of vagina. The results showed that the space from the posterior wall of the vagina to the anterior wall of the rectum at the upper 1/3 level and the middle level was 3.896 ± 0.3617 mm and 4.6575 ± 0.3052 mm, respectively. When the two groups of data were compared, we found the space at the upper 1/3 level was shorter than at the middle level (P < 0.01. Moreover, at the lower 1/3 level the space measured was 10.058 ± 0.4534 mm. The results revealed that the space at the lower 1/3 level was longer than that at the middle level (P < 0.01.CONCLUSION: These measurement data may be helpful in assessing rectocele clinical diagnosis and functional outcomes of rectocele repair.

Jin Liu, Li-Dong Zhai, Yun-Sheng Li, Wan-Xiang Liu, Rui-Hua Wang

2009-06-01

122

CT and MR imaging findings of primary leiomyosarcoma of the vagina : a case report  

International Nuclear Information System (INIS)

Primary malignant lesions of the vagina are uncommon and represent approximately 1-2% of all gynecologic malignancies. About 2% of all malignant vaginal lesions are primary sarcomas, the most common of these being leiomyosarcoma. We report the CT and MR imaging findings in a 41-year-old woman with vaginal leiomyosarcoma presenting as a bulky solid mass which caused expansion of the vaginal canal

2001-09-01

123

Long-term results of radiotherapy in primary carcinoma of the vagina  

Energy Technology Data Exchange (ETDEWEB)

Background: The long-term results of radiotherapy in primary carcinoma of the vagina are not well defined. Patients and Methods: The treatment results of 41 patients with primary malignancies of the vagina were analyzed. The mean follow-up period was 77.3 months (2.3-404 months). The predominant histology was squamous cell carcinoma, FIGO stages I: n = 7 (17.1%), II: n = 13 (31.7%), III: n = 13 (31.7%), and IVa: n = 8 (19.5%). Radiotherapy was the primary treatment for all patients. None of the patients had undergone prior surgery for vaginal carcinoma. The majority of patients received pelvic irradiation, including treatment of the inguinal lymphatics (median dose: 50 Gy). 26 patients received additional intravaginal brachytherapy. Results: Overall, 21 patients (51.2%) achieved complete remission, 17 patients (41.5%) had partial responses, and three patients (7.3%) had no change or progressive disease. The total median survival of the analyzed patients was 41.3 months. The 1-year survival probability was 85.4%, the 5-year survival probability 40.6%, and the 10-year survival probability 27.2%. Univariate analysis revealed a survival advantage for earlier tumor stages (FIGO I and II) compared to advanced stages (FIGO III and IV), with a median survival of 58.1 months compared to 26.8 months. Treatment side effects were tolerable and easily managed. Conclusion: Definite radiotherapy is the treatment of choice for primary carcinomas of the vagina. Considering that primary malignancies of the vagina are typically diseases of the elderly, it should be noted that radiotherapy is especially well tolerated in this population. (orig.)

Hegemann, Stefan; Willich, Normann [University Hospital, Muenster (Germany). Dept. of Radiotherapy and Radiation Oncology; Schaefer, Ulrich [University Hospital, Muenster (Germany). Dept. of Radiotherapy and Radiation Oncology; Lippe Hospital, Lemgo (Germany). Dept. of Radiotherapy; Lelle, Ralph [University Hospital, Muenster (Germany). Dept. of Gynecology and Gynecologic Oncology; Micke, Oliver [University Hospital, Muenster (Germany). Dept. of Radiotherapy and Radiation Oncology; Franziskus Hospital, Bielefeld (Germany). Dept. of Radiotherapy and Radiation Oncology

2009-03-15

124

Hematocolpos in double vagina associated with uterus didelphus: US and MR findings  

Energy Technology Data Exchange (ETDEWEB)

The malformative syndrome of double vagina in association with uterus didelphus and kidney agenesis is a rare condition, often asymptomatic: if this condition is accompanied by imperforated obstructed hemivagina, the clinical manifestations depend on the presence of hematocolpos. MRI plays an important role for diagnosis because it allows to characterize the nature of the lesion and to evaluate the anatomical details of the uterine malformation. The authors describe this complex genital malformation and discuss the main US and MRI features.

Ballesio, L.; Andreoli, C.; De Cicco, M.L.; Angeli, M.L.; Manganaro, L

2003-02-01

125

Foreign body in vagina: a cause of persistent vaginal discharge in children  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Vulvovaginitis and vaginal discharge in pediatric patients, while not uncommon, is commonly believed to be due to such causes as absence of the protective effect on the vaginal mucosa. However, other causes need also to be kept in mind. We report a case of chronic vaginal discharge in a 5 yr old, who had retained a foreign body in her vagina for 6-7 months. [Int J Reprod Contracept Obstet Gynecol 2013; 2(2.000): 224-225

Pallavee, P.; Sunita Samal; Sabita, P.

2013-01-01

126

Foreign body in vagina: a cause of persistent vaginal discharge in children  

Directory of Open Access Journals (Sweden)

Full Text Available Vulvovaginitis and vaginal discharge in pediatric patients, while not uncommon, is commonly believed to be due to such causes as absence of the protective effect on the vaginal mucosa. However, other causes need also to be kept in mind. We report a case of chronic vaginal discharge in a 5 yr old, who had retained a foreign body in her vagina for 6-7 months. [Int J Reprod Contracept Obstet Gynecol 2013; 2(2.000: 224-225

P. Pallavee

2013-04-01

127

Hematocolpos in double vagina associated with uterus didelphus: US and MR findings  

International Nuclear Information System (INIS)

The malformative syndrome of double vagina in association with uterus didelphus and kidney agenesis is a rare condition, often asymptomatic: if this condition is accompanied by imperforated obstructed hemivagina, the clinical manifestations depend on the presence of hematocolpos. MRI plays an important role for diagnosis because it allows to characterize the nature of the lesion and to evaluate the anatomical details of the uterine malformation. The authors describe this complex genital malformation and discuss the main US and MRI features

2003-02-01

128

CT and MR imaging findings of primary leiomyosarcoma of the vagina : a case report  

Energy Technology Data Exchange (ETDEWEB)

Primary malignant lesions of the vagina are uncommon and represent approximately 1-2% of all gynecologic malignancies. About 2% of all malignant vaginal lesions are primary sarcomas, the most common of these being leiomyosarcoma. We report the CT and MR imaging findings in a 41-year-old woman with vaginal leiomyosarcoma presenting as a bulky solid mass which caused expansion of the vaginal canal.

Cho, So Hee; Rha, Sung Eun; Cho, Song Mee; Byun, Jae Young [College of Medicine, The Catholic Univ. of Korea, Seoul (Korea, Republic of)

2001-09-01

129

Verrucous carcinoma of the cervix and vagina treated by radiation therapy  

International Nuclear Information System (INIS)

Seven cases of verrocous carcinoma of the uterine cervix (five) and vagina (two) were reviewed. Four of the five patients managed primarily with radiation therapy have survived a median of 10 years. Of the two patients managed primarily with surgery, one experienced recurrence and was then successfully treated with radiation therapy; the other died of metastatic carcinoma. No anaplastic transformation of lesions or distant metastases occurred in the patients treated with radiation therapy. Human papilloma virus was isolated in two patients

1986-12-05

130

Long-term results of radiotherapy in primary carcinoma of the vagina  

International Nuclear Information System (INIS)

Background: The long-term results of radiotherapy in primary carcinoma of the vagina are not well defined. Patients and Methods: The treatment results of 41 patients with primary malignancies of the vagina were analyzed. The mean follow-up period was 77.3 months (2.3-404 months). The predominant histology was squamous cell carcinoma, FIGO stages I: n = 7 (17.1%), II: n = 13 (31.7%), III: n = 13 (31.7%), and IVa: n = 8 (19.5%). Radiotherapy was the primary treatment for all patients. None of the patients had undergone prior surgery for vaginal carcinoma. The majority of patients received pelvic irradiation, including treatment of the inguinal lymphatics (median dose: 50 Gy). 26 patients received additional intravaginal brachytherapy. Results: Overall, 21 patients (51.2%) achieved complete remission, 17 patients (41.5%) had partial responses, and three patients (7.3%) had no change or progressive disease. The total median survival of the analyzed patients was 41.3 months. The 1-year survival probability was 85.4%, the 5-year survival probability 40.6%, and the 10-year survival probability 27.2%. Univariate analysis revealed a survival advantage for earlier tumor stages (FIGO I and II) compared to advanced stages (FIGO III and IV), with a median survival of 58.1 months compared to 26.8 months. Treatment side effects were tolerable and easily managed. Conclusion: Definite radiotherapy is the treatment of choice for primary carcinomas of the vagina. Considering that primary malignancies of the vagina are typically diseases of the elderly, it should be noted that radiotherapy is especially well tolerated in this population. (orig.)

2009-03-01

131

Fewer Trichomonas vaginalis organisms in vaginas of infected women during menstruation.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The aims of the present study were to count Trichomonas vaginalis organisms recovered from the vaginas of patients with trichomoniasis, and to obtain data concerning changes in sizes of trichomonal populations during the menstrual cycle. In about 80% of symptomatic as well as symptomless patients, more than 1 x 10(5) parasites per ml could be obtained from vaginal washes. During menstruation, however, the number of trichomonads decreased appreciably, with subsequent increases within three to ...

Fox, H.

1988-01-01

132

LOXL1 deficiency negatively impacts the biomechanical properties of the mouse vagina and supportive tissues  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Mice deficient in lysyl oxidase-like1 protein (LOXL1?/?) develop pelvic organ prolapse (POP). We sought to determine the impact of LOXL1?/? on the biomechanical properties of the vagina and its supportive tissues tested as a complex. Tissues of nulliparous LOXL1?/? and age-matched wild type (WT) mice were tested to failure to obtain load-distension curves. Data were compared utilizing one-way analysis of variance and appropriate post hoc tests. The groups demonstrated different bi...

2008-01-01

133

Effect of prolonged use of high dose of tibolone on the vagina of ovariectomized rats.  

Science.gov (United States)

The aim of this study was evaluate the effect of prolonged use of high dose of tibolone on the vagina of ovariectomized rats. Bilateral ovariectomy was performed on 14 rats weighing 250 g. Thirty days later, vaginal smears were collected verifying the menopause status by anoestrus cytology. Rats were divided randomly into groups: experimental rats (n = 9) received 1 mg tibolone/day orally and control rats (n = 6) received placebo (carboxymethylcellulose). After 150 days, all rats were sedated and euthanized by cervical displacement. The vagina was removed, fixed in 10% buffered formalin, sampled and processed for paraffin embedding. Histological sections were stained with haematoxylin and eosin, picrosirius red, periodic acid Schiff (PAS) and PAS-diastase, and Weigert's resorcin-fuchsin. Cell proliferation was analysed by immunohistochemistry to detect Ki67. Histomorphometric analyses were performed for epithelial thickness, per cent area of collagen fibres and blood vessels, mast cells and Ki67-positive nuclei per mm of basal membrane. Means and standard error of means were calculated, and data were compared using the Mann-Whitney test, with significance level at P tibolone group when compared with the control group. Furthermore, the content of glycogen and glycoproteins in the vaginal epithelium was modified by tibolone. Tibolone administered in high dose and for a long period has a trophic effect, reversing vaginal atrophy, and has no dysplastic or neoplastic effect in the vagina of ovariectomized rats. PMID:21518049

Henriques, Helene Nara; de Carvalho, Ana Carolina Bergmann; Soares Filho, Porphirio José; Pantaleão, José Augusto Soares; Guzmán-Silva, Maria Angélica

2011-08-01

134

Association of Atopobium vaginae, a recently described metronidazole resistant anaerobe, with bacterial vaginosis  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Bacterial vaginosis (BV is a polymicrobial syndrome characterized by a change in vaginal flora away from predominantly Lactobacillus species. The cause of BV is unknown, but the condition has been implicated in diverse medical outcomes. The bacterium Atopobium vaginae has been recognized only recently. It is not readily identified by commercial diagnostic kits. Its clinical significance is unknown but it has recently been isolated from a tuboovarian abcess. Methods Nucleotide sequencing of PCR amplified 16S rRNA gene segments, that were separated into bands within lanes on polyacrylamide gels by denaturing gradient gel electrophoresis (DGGE, was used to examine bacterial vaginal flora in 46 patients clinically described as having normal (Lactobacillus spp. predominant; Nugent score ? 3 and abnormal flora (Nugent score ? 4. These women ranged in age from 14 to 48 and 82% were African American. Results The DGGE banding patterns of normal and BV-positive patients were recognizably distinct. Those of normal patients contained 1 to 4 bands that were focused in the centre region of the gel lane, while those of BV positive patients contained bands that were not all focused in the center region of the gel lane. More detailed analysis of patterns revealed that bands identified as Atopobium vaginae were present in a majority (12/22 of BV positive patients, while corresponding bands were rare (2/24 in normal patients. (P A. vaginae isolates were cultivated from two patients whose DGGE analyses indicated the presence of this organism. Two A. vaginae 16S rRNA gene sequences were identified among the clinical isolates. The same two sequences were obtained from DGGE bands of the corresponding vaginal flora. The sequences differed by one nucleotide over the short (~300 bp segment used for DGGE analysis and migrated to slightly different points in denaturing gradient gels. Both isolates were strict anaerobes and highly metronidazole resistant. Conclusion The results suggest that A. vaginae may be an important component of the complex bacterial ecology that constitutes abnormal vaginal flora. This organism could play a role in treatment failure if further studies confirm it is consistently metronidozole resistant.

Fortenberry J Dennis

2004-02-01

135

The social vagina: labia elongation and social capital among women in Rwanda  

DEFF Research Database (Denmark)

Far from being an individual concern, vaginas are located within complex socio-cultural settings. The acceptability of policies that focus on health-promoting behavioural change is influenced by values regarding normative gender and sexual roles. In Rwanda, the elongation of the labia minora through manual manipulation is not an individual act but takes place in social groups and thus cannot be fully understood by focusing one's attention solely on the individual-related behavioural components but, rather, on the social environment in which it exists. This paper aims to increase knowledge about labia elongation and assesses whether this vaginal practice produce social capital.

Larsen, Josefine Kühnel

2010-01-01

136

Devices for interstitial radiotherapy of recurrents and metastases of uterine cancer to the vagina  

International Nuclear Information System (INIS)

Three types of devices for interstitial radiotherapy have been developed in accordance with the technique of successive manual introduction of intrastates and radioactive sources taking into account localization, size, and degree of infiltration of underlaid tissues of recurrent and metastatic tumors during uterine cancer in all vagina sections. The proposed fixing devices provide safe predetermined source position and allow one to conduct local irradiation of pathological focus with minimum radiation loading on adjacensst organs and tiues, simplify dosimetric calculations of absorbed doses and reduce time of manipulation with radioactive sources

1984-01-01

137

Pre leukemic granulocytic sarcoma of vagina: a case report with review of literature  

International Nuclear Information System (INIS)

Granulocytic sarcoma is an extramedullary tumor of malignant granulocytic progenitor cells, that may precede the onset of acute myeloid leukemia or appear during the leukemic manifestation or blastic crisis of chronic myeloproliferative disorders. A case of granulocytic sarcoma of vagina in a 27 year old woman treated with local radiotherapy is described. After seven months of follow up she developed acute myeloid leukemia. The case has been presented in view of its rarity and discussed in light of the available literature. (author). 13 refs., 1 fig

1996-09-01

138

The relative efficacy of HDR and LDR interstitial brachytherapy in squamous cell carcinoma of vagina  

International Nuclear Information System (INIS)

Introduction: Beginning in 1982 we performed low dose rate (LDR) interstitial template brachytherapy (ISTB) for carcinoma of the vagina. High dose rate (HDR) remote afterloading has been used exclusively since 1991. We compare the results LDR and HDR brachytherapy. Material and Methods: Between 1982 and 1994, 30 patients with primary squamous cell carcinoma of vagina received external beam radiotherapy (EBRT) and brachytherapy. The AJCC stage distribution was 3 stage I, 25 stage II, and 2 stage III. The average central pelvic EBRT dose was 35 Gy. Pelvic side wall EBRT doses ranged from 45 to 50.4 Gy. Nineteen patients had LDR treatment; 3 intracavitary brachytherapy (ICB) and 16 ISTB. Eleven patients had HDR treatment; 2 ICB and 9 ISB. The average dose delivered by LDR was 41.2 Gy usually in 2 fractions, and by HDR 32.5 Gy in 6 fractions of 500-550 cGy. Local failures were confirmed pathologically. The absolute survival (AS) and relapse-free survival (RFS) were calculated using Kaplan-Meier method and compared with logrank statistics. Results: The mean follow-up was 77 months for LDR and 23 months for HDR. Local and regional control was achieved in 90% (27/30) of the patients. Three year AS was 84% and RFS was 87%. There was no significant difference between LDR and HDR in AS, RFS or local-regional control, (log rank p=0.85, p=0.12 and p=0.35 respectively). The single HDR local failure presented in a patient with extensive stage II disease who declined ISTB. There were fewer complications following HDR. The 1 case of extensive vaginal necrosis and the 3 cases of rectovaginal fistula that required surgery occurred only with LDR brachytherapy. Discussion: Excellent local and regional control of carcinoma of the vagina can be achieved by administering limited doses of external radiation and brachytherapy. Interstitial template implants are the best means of encompassing paravaginal disease while sparing the adjacent uninvolved normal tissues from high doses of radiation. HDR technology is an effective means of administering high uniform tumor doses, maximizes dose control to the bladder and rectum and improves radiation safety. Conclusion: Optimal tumor control and less morbidity at 2 years after treatment can be achieved with HDR-ISTB in squamous carcinoma of the vagina compared to alternative treatments

1996-05-01

139

The social vagina: labia elongation and social capital among women in Rwanda.  

Science.gov (United States)

Far from being an individual concern, vaginas are located within complex socio-cultural settings. The acceptability of policies that focus on health-promoting behavioural change is influenced by values regarding normative gender and sexual roles. In Rwanda, the elongation of the labia minora through manual manipulation is not an individual act but takes place in social groups and thus cannot be fully understood by focusing one's attention solely on the individual-related behavioural components but, rather, on the social environment in which it exists. This paper aims to increase knowledge about labia elongation and assesses whether this vaginal practice produce social capital. PMID:20665297

Larsen, Josefine

2010-10-01

140

Role of radiation therapy in the management of primary carcinoma of the vagina  

International Nuclear Information System (INIS)

A retrospective analysis of 88 patients with microscopically proven primary carcinoma of the vagina is presented. All patients were treated between 1957 and 1975 and have been followed for a minimum of 5 years. The technique of treatment, external, intracavitary and interstitial irradiation has been highly integrated and individualized. Several important features could be drawn from the current data: (1) The necessity for individualized radiation treatment to achieve the success, (2) the necessity to subdivide stage II into II A and II B is clearly shown by the 5-year survival data, (3) a relatively low complication rate from the use of high dose combined radiation modalities in higher stages is demonstrated. (Auth.)

1982-01-01

 
 
 
 
141

Melanosis of the vagina and human papillomavirus infection, an uncommon pathology: Case Report / Melanosis de la vagina e infección por virus del papiloma humano, una patología poco común: Reporte de un Caso  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: English Abstract in spanish Las lesiones melanóticas de la vagina son infrecuentes. y Solo pocos casos han sido reportados. Se presenta el caso de una mujer de 34 años quien es referida con diagnóstico de una Neoplasia Intraepitelial Vaginal 1. Al examen ginecológico, se encontraron dos áreas hiperpigmentadas en la vagina. La [...] exploración colposcópica del cuello uterino y vagina reveló la presencia de una lesión aceto-blanca en la pared lateral derecha del tercio superior de la vagina. Muestras de biopsias fueron tomadas en dichas áreas. El estudio histológico reportó una melanosis de la vagina y una infección por el virus del Papiloma Humano (VPH). Se realizó un panel de estudio inmunohistoquímico de marcadores epiteliales en las muestras vaginales: tales como citoqueratina AE1/AE3 y antígeno epitelial de membrana; marcador mesenquimal: vimentin; marcadores melanóticos: proteina S-100 y HMB45 (Human Melanoma Black); marcadores de proliferación celular: antígeno de proliferación nuclear (PCNA), y la oncoproteína P-53. Se realizó Hibridización In Situ para establecer los tipos de alto (16, 18, 31, 45) y bajo (6, 11) riesgo de VPH en las muestras vaginales. Los marcadores CK, EMA y Vimentin fueron 2+. Los marcadores melanótico, el HMB45 y el S100, y el PCNA fueron 1+ en la capa basal. P-53 fue negativo. El tejido melanótico y la lesión acetoblanca fueron positivos al VPH 6,11. En conclusión, la melanosis vaginal es una patología poco frecuente. Usualmente, se ha reportado en mujeres mayores de 40 años. Presentamos un caso de una melanosis de la vagina infectada con un tipo de VPH de bajo riesgo en una mujer joven y una revisión de la literatura. Abstract in english Benign melanotic lesions of the vagina are uncommon and only a few cases have been reported in the literature. A 34-year-old woman was referred because of a Vaginal Intraepithelial Neoplasia 1 biopsy result. On the gynecological examination, two different hyperpigmented areas were noted in the vagin [...] a. The colposcopic visualization of the cervix and vagina found an aceto-white lesion at the right lateral wall of the upper third of the vagina. Biopsies from three areas were taken. Histological study reported a melanosis of the vagina and HPV infection. An immunohistochemical panel of epithelial markers was performed in vaginal samples, such as Cytokeratin AE1/AE3 and epithelial membrane antigen, mesenchymal marker: vimentin; melanocytic makers: protein S-100 and HMB45 (Human Melanoma Black); proliferating cell marker: proliferating cell nuclear antigen (PCNA), and P-53 oncoprotein. High Risk (16, 18, 31, 45) and Low Risk (6, 11) HPV types were studied by In Situ Hybridization using the same vaginal samples. CK, EMA and Vimentin were 2+. Melanocytic markers, HMB45 and S100, and PCNA were 1+ in basal cell layer. P-53 was negative. The melanotic tissue and acetowhite lesion were positives to HPV Types 6,11. In conclusion, melanosis of the vagina is a uncommon benign pathology. Usually, melanosis is present in women over 40 years old. We present a case of melanosis of the vagina in a young woman infected with low-risk HPV types and review the literature.

José, Núñez-Troconis; Mariela, Delgado; Gerardo, González; Airiaudis, Rivas; Katherine, Molero.

142

Antibiogram of Group B Streptococci Isolated from the Vagina of Pregnant  

Directory of Open Access Journals (Sweden)

Full Text Available Group B streptococcal (GBS prevalence varies from place to place; this organism is responsible for serious infections in newborns, such as septicemia and meningitis. The present study was aimed to find out the antibiogram of Group B Streptococci isolated from the vagina of pregnant women who were in the third trimester of pregnancy and toidentify the risk factors for its colonization in vagina. The study was carried out in the Department of Microbiology, M. R. Medical College & Hospital, Gulbarga during a period from January 2007 to December 2007. Two hundred pregnant women who were in the third trimester of pregnancy and attending the antenatal clinics were included in the study. Two low vaginal swabs were taken from each women included in the study and were immediately transported to the laboratory for processing. Direct gram staining was done from one swab and the other swab was inoculated into sheep blood agar plate and incubated at 37ºC for 24-48 hours. Identification of organism was based on gram staining, colony morphology, catalase reaction,Christie Atkins Munch Petersen (CAMP and Hippurate hydrolysis test.Of the 200 pregnant women screened, 7.5% were colonized by GBS. Incidence of GBS colonization was higher among pregnant women in the third trimester who were 25 years of age and primigravida. All the isolates were sensitive to Ampicillin, Erythromycin and Penicillin but were resistant to Gentamicin and Kanamycin.

Vinay Hajare, *L.H. Madhavi, **H.K.G. Singh

2012-01-01

143

Foreign Body in Vagina: An Uncommon Cause of Vaginitis in Children  

Science.gov (United States)

Vaginal discharge in children may result from a variety of causes. A long-standing intra-vaginal foreign body can pose both diagnostic and therapeutic challenges in children. Treatment failure may occur because of alteration of the normal vaginal flora. A 6-year-old girl, who lived with her parents, presented with a foul-smelling, blood-stained vaginal discharge as well as dysuria for 2 years. There was no history of sexual abuse. Initial evaluation that excluded gynecologic examination revealed lower abdominal tenderness. Vaginal swab and urine cultures yielded Staphylococcus aureus sensitive to ceftriaxone only. She was commenced on this antibiotic for 2 weeks, but the discharge persisted, necessitating referral to the gynecologist. Examination under anesthesia by the gynecologist revealed shreds of toilet tissue paper extracted from the vagina and slight excoriations on the wall of the vagina. Vaginal foreign body can present with diverse symptoms. It should be considered in any young female patient presenting with recurrent or persistent vaginal discharge.

Chinawa, JM; Obu, HA; Uwaezuoke, SN

2013-01-01

144

Bilateral single ectopic ureters draining into a grossly dilated vagina in an adolescent female.  

Science.gov (United States)

A 16-year-old female presented with dribbling of urine along with voluntary voiding since birth. Renal imaging revealed hydroureteronephrosis on the right side; the uterus and ovary were normal. A radionuclide scan showed a left nonfunctional kidney. On cystovaginoscopy, the urethra was shown to be normal and the urinary bladder was tubular with small capacity and an absent trigone. Although the vagina was capacious, no ureteric orifices were found. Computed tomography corroborated the diagnosis of bilateral, single ectopic ureters draining into a grossly dilated vagina. This case is unique because it is a bilateral single-system ureteral ectopia in a completely differentiated female genital tract that presented late in adolescence. To the best of our knowledge, this is the second such ureteral abnormality reported in the literature so far. The patient underwent ileocystoplasty with right ureteric reimplantation and nephroureterectomy for the left nonfunctional kidney, which histopathology showed to be tuberculosis. The patient is continent with cystometric capacity of more than 300 mL. PMID:23878693

Mandal, Soumendra Nath; Jagadheesan, Gokulakrishnan Puttuthakku; Kamal, Mir Reza; Mukherjee, Satyadip; Das, Ranjit Kumar; Karmakar, Dilip

2013-07-01

145

A longitudinal study of Staphylococcus hyicus colonization of vagina of gilts and transmission to piglets  

DEFF Research Database (Denmark)

High Staphylococcus hyicus colonization rates were found in vaginal samples of healthy breeding sows and in skin samples of their offspring. Twenty-two different phage types were identified among the 720 isolates of S. hyicus examined. Two to 13 different phage types were isolated per herd. Phage typing, as well as characterization of about 10 % of the isolates by plasmid profiles and antibiogram patterns, showed that, several different clones of S. hyicus could be present simultaneously in vagina of gilts and also on skin of piglets. Generally isolates from the vagina of one animal were identical as regards to phage types, plasmid profiles, and antibiogram patterns during the entire investigation period. Isolates from the skin of piglets were of the same type as their mothers, indicating that vertical transmission had taken place. S. hyicus strains isolated from the skin of piglets within 24 h after birth were identical to strains isolated 3 weeks after birth from the same litter, indicating that the vaginalstrains became part of a stable skin flora.

Wegener, Henrik Caspar; Skov Jensen, E.W.

1992-01-01

146

Migration of a particulate radioactive tracer from the vagina to the peritoneal cavity and ovaries  

International Nuclear Information System (INIS)

In this report we describe a radionuclide procedure designed to evaluate the migration of a particulate radioactive tracer from the vagina to the peritoneal cavity and ovaries, as well as the determination of the patency of the pathways between these two extremes of the female reproductive system. Technetium-99m-labelled human albumin microspheres (technetium-99m-HAM) were deposited in the posterior fornices of 24 patients a day before they were to undergo different gynaecological operations. During this period sequential images were obtained and after the operation radioactivity levels in the removed organs and tissues were counted with a scintillation detector. In 14 out of 21 cases, the ovaries and fallopian tubes were counted separately from the uterus. Nine were positive (radioactivity levels were sufficiently high in the tubes and ovaries) and 5 were negative (no substantial radioactivity levels could be detected in either the tubes or the ovaries). The 5 negative results all occurred in patients with proved tubal damage as a result of previous infection. All the results were either true positive or true negative, providing evidence of migration, or obstruction, of technetium-99m-HAM from the vagina through the uterus and tubes to the peritoneal cavity and ovaries

1979-06-02

147

LOXL1 deficiency negatively impacts the biomechanical properties of the mouse vagina and supportive tissues.  

Science.gov (United States)

Mice deficient in lysyl oxidase-like1 protein (LOXL1(-/-)) develop pelvic organ prolapse (POP). We sought to determine the impact of LOXL1(-/-) on the biomechanical properties of the vagina and its supportive tissues tested as a complex. Tissues of nulliparous LOXL1(-/-) and age-matched wild type (WT) mice were tested to failure to obtain load-distension curves. Data were compared utilizing one-way analysis of variance and appropriate post hoc tests. The groups demonstrated different biomechanical behavior, with LOXL1(-/-) animals displaying a 31% decrease in ultimate load at failure (p=0.001). Experimental disruption of specific levels of support in WT mice failed to generate load-distension curves similar to the LOXL1(-/-) mice indicating a global instead of a site-specific tissue defect. The decrease in the ultimate load at failure in the LOXL1(-/-) mice suggests mechanically weaker tissues. LOXL1 mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues. PMID:18265927

Alperin, Marianna; Debes, Kristen; Abramowitch, Steven; Meyn, Leslie; Moalli, Pamela A

2008-07-01

148

A Case Report of Cervical Rhabdomyosarcoma with the Complaint of a Mass Protrusion from Vagina with Bleeding and Vaginal Discharge  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Botyroide sarcoma is one of the rhabdomyosarcoma which is usually seen in infant's vagina. However, it rarely originates from uterine cervix. Rhabdomyosarcoma is a heterogenic tumor and it is usually diagnosed in second decade of life.Case Report: The patient was a 17 years old virgin girl with the complaint of a mass protrusion from vagina with bleeding and vaginal discharge. Biopsy samples and immunohistochemistry assessments showed embryonal rhabdomyosarcoma. Surgery combined with chemotherapy, significantly increased the survival of patients with uterine cervical rhabdomyosarcoma. Conclusion: The patient underwent radical hysterectomy with restored ovaries and then combined chemotherapy. In the 9 months follow up recurrence has not been observed yet.

M. Arab

2006-10-01

149

Absence of a vagina and right sided adnexa uteri in the Waardenburg syndrome: a possible clue to the embryological defect.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

An 18 year old single Jewish woman with the Waardenburg syndrome and absence of a vagina and right sided adnexa uteri is reported. Other congenital malformations associated with the Waardenburg syndrome are mentioned and it is postulated that they may be the result of an altered invasion of neurones or altered neurones in certain organ systems early in embryogenesis.

Goodman, R. M.; Oelsner, G.; Berkenstadt, M.; Admon, D.

1988-01-01

150

Reconstruction of the anus, rectovaginal septum, and distal part of the vagina after postirradiation necrosis. Report of a unique case  

International Nuclear Information System (INIS)

Successful repair of postirradiation total loss of the anal sphincters, rectovaginal septum, and distal part of the vagina is reported. Gracilis muscle flap was used as a substitute sphincter. Part of the muscle was wrapped-up in a split skin graft. To the authors' knowledge, this is the first report on new application of gracilis muscle and split skin graft in perineal reconstruction

1988-01-01

151

Complete genome sequence of Lactococcus lactis subsp. lactis CV56, a probiotic strain isolated from the vaginas of healthy women.  

Science.gov (United States)

Lactic acid bacteria that exist in the urinogenital system play an important role in maintaining the health of the host. Here, we report the finished and annotated genome of a Lactococcus strain that was isolated from the vaginas of healthy women and shows probiotic properties, including nisin A production and adhesion to vaginal epithelial cells. PMID:21460077

Gao, Yong; Lu, Ying; Teng, Kun-Ling; Chen, Mei-Ling; Zheng, Hua-Jun; Zhu, Yong-Qiang; Zhong, Jin

2011-06-01

152

Complete Genome Sequence of Lactococcus lactis subsp. lactis CV56, a Probiotic Strain Isolated from the Vaginas of Healthy Women?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Lactic acid bacteria that exist in the urinogenital system play an important role in maintaining the health of the host. Here, we report the finished and annotated genome of a Lactococcus strain that was isolated from the vaginas of healthy women and shows probiotic properties, including nisin A production and adhesion to vaginal epithelial cells.

Gao, Yong; Lu, Ying; Teng, Kun-ling; Chen, Mei-ling; Zheng, Hua-jun; Zhu, Yong-qiang; Zhong, Jin

2011-01-01

153

Paraganglioma of the vagina: a case report and review of the literature  

Science.gov (United States)

Vaginal paraganglioma is a rare and unusual tumor occurring in the vaginal wall. It is a solitary primary paraganglioma, especially in atypical sites. Herein, we report an unusual case of a 17-year-old woman who had not experienced vomiting, or hypertension. She was found to have an immobile solid mass in the right side of her vaginal wall. Positron emission tomography/computed tomography scans revealed a well-defined solid ovoid mass adjacent to the bladder and pelvic floor. Tumor markers were within the normal range. A transient blood pressure increase occurred during the biopsy. After oral administration of antihypertensive drugs, surgery was performed to completely remove the mass. Histopathological examination indicated that it was a paraganglioma of the vagina. Repeat computed tomography examination did not reveal any local recurrence or distant metastasis during the 12-month follow-up period.

Cai, Tao; Li, Yucong; Jiang, Qingming; Wang, Dong; Huang, Yu

2014-01-01

154

Integrated external and interstitial radiation therapy for primary carcinoma of the vagina  

International Nuclear Information System (INIS)

Twenty-seven patients with the diagnosis of primary carcinoma of the vagina were treated by definitive radiotherapy. Twenty-three patients received a combination of external and interstitial iridium-192 implant irradiation and four patients received only interstitial irradiation. Twenty-one patients had squamous cell carcinoma and six had adenocarcinoma. All patients were staged according to the FIGO classification. More than 70% of patients had relatively advanced local disease and conventional intracavitary irradiation was unsuitable. Local tumor control was observed in 85% (23 of 27 patients), and 56% of the patients remain alive and free of disease for a median follow-up period of 50 months to a maximum follow-up period of 84 months. Fifteen percent of the patients suffered from treatment-related complications

1983-01-01

155

Microbiological analysis of the uterus and vagina of nulliparous and non-nulliparous agoutis (Dasyprocta azarae  

Directory of Open Access Journals (Sweden)

Full Text Available The genital organs of domestic animals are usually colonized by several microorganisms. This paper aims at describing the uterine and vaginal microbiota of nulliparous and non-nulliparous agoutis, which belong to the Catanduva City Zoo, Sao Paulo, Brazil. During the procedure of ovariosalpingohisterectomy, material was collected for microbiological analysis through the introduction of sterile swabs in the vagina and in each uterine horn. The presence of Proteus sp. was observed in the uterine material of only one animal. In the vaginal material of all animals, several bacteriae (Proteus sp., Escherichia coli, Citrobacter sp., Pseudomonas sp., and Staphylococcus sp. and yeasts were found. The vaginal and uterine microbiota of agoutis presents a colonization pattern different from that observed in other domestic animals, in women, and in female rats.

Leandro Luis Martins

2012-11-01

156

Radiation therapy for primary squamous cell carcinoma of the vagina: Stanford University experience  

International Nuclear Information System (INIS)

A retrospective analysis of 38 patients with primary squamous cell carcinoma of the vagina seen at Stanford University Medical Center from 1958 to 1984 was undertaken. Patients were analyzed with regard to symptoms, stage, treatment techniques, survival, patterns of failure, and complications. Eighteen patients were classified as FIGO Stage I, 5 as Stage II, 10 as Stage III, and 5 as Stage IV. The 5-year disease-free survival was 94% in Stage I, 80% in Stage II, 50% in Stage III, and 0% in Stage IV. Five patients (13%) had eight major complications secondary to treatment. Only 2 of 23 patients with Stage I or Stage II disease developed a recurrence. There was a significant correlation between dose and response in patients treated with radiotherapy

1989-01-01

157

Absence of vagina and hypoplasia of the urethra and ectopia of the ureter.  

Science.gov (United States)

A 16-year-old Japanese girl was admitted for evaluation of complaints of primary amenorrhea, cyclic lower abdominal pain, and urinary incontinence. Her vaginal introitus appeared rudimentary with a depth of 0.5 cm and hypoplasia of the hymenal ring. A hypoplastic urethra (diameter: 1 cm; length: 0.5 cm) and 1 of 2 right ectopic ureters opened into the introitus. Transabdominal ultrasonography demonstrated fluid distending the uterus, the proximal 1/3 of the vagina, and the pouch of Douglas. Computed tomography (CT) and magnetic resonance imaging (MRI) confirmed the presence of hematometrocolpos and fluid collection in the pouch of Douglas. These associated anomalies can be due to faulty growth of the urogenital sinus. In addition to the transabdominal ultrasonography and CT, MRI was useful in the diagnosis and evaluation of vaginal agenesis. PMID:8987327

Nasu, K; Yoshimatsu, J; Miyakawa, I; Nakagawa, M; Nomura, Y

1996-10-01

158

Influence of Reproductive Status on Tissue Composition and Biomechanical Properties of Ovine Vagina  

Science.gov (United States)

Objective To undertake a comprehensive analysis of the biochemical tissue composition and passive biomechanical properties of ovine vagina and relate this to the histo-architecture at different reproductive stages as part of the establishment of a large preclinical animal model for evaluating regenerative medicine approaches for surgical treatment of pelvic organ prolapse. Methods Vaginal tissue was collected from virgin (n?=?3), parous (n?=?6) and pregnant sheep (n?=?6; mean gestation; 132 d; term?=?145 d). Tissue histology was analyzed using H+E and Masson's Trichrome staining. Biochemical analysis of the extracellular matrix proteins used a hydroxyproline assay to quantify total collagen, SDS PAGE to measure collagen III/I+III ratios, dimethylmethylene blue to quantify glycosaminoglycans and amino acid analysis to quantify elastin. Uniaxial tensiometry was used to determine the Young's modulus, maximum stress and strain, and permanent strain following cyclic loading. Results Vaginal tissue of virgin sheep had the lowest total collagen content and permanent strain. Parous tissue had the highest total collagen and lowest elastin content with concomitant high maximum stress. In contrast, pregnant sheep had the highest elastin and lowest collagen contents, and thickest smooth muscle layer, which was associated with low maximum stress and poor dimensional recovery following repetitive loading. Conclusion Pregnant ovine vagina was the most extensible, but the weakest tissue, whereas parous and virgin tissues were strong and elastic. Pregnancy had the greatest impact on tissue composition and biomechanical properties, compatible with significant tissue remodeling as demonstrated in other species. Biochemical changes in tissue protein composition coincide with these altered biomechanical properties.

Ulrich, Daniela; Edwards, Sharon L.; Su, Kai; White, Jacinta F.; Ramshaw, John A. M.; Jenkin, Graham; Deprest, Jan; Rosamilia, Anna

2014-01-01

159

DETERIORATION IN BIOMECHANICAL PROPERTIES OF THE VAGINA FOLLOWING IMPLANTATION OF A HIGH STIFFNESS PROLAPSE MESH  

Science.gov (United States)

Objective Define the impact of prolapse mesh on the biomechanical properties of the vagina by comparing the prototype Gynemesh PS (Ethicon, Somerville, NJ) to 2 new generation lower stiffness meshes, SmartMesh (Coloplast, Minneapolis, MN) and UltraPro (Ethicon). Design A study employing a non-human primate model Setting University of Pittsburgh Population 45 parous rhesus macaques Methods Meshes were implanted via sacrocolpexy after hysterectomy and compared to Sham. Because its stiffness is highly directional UltraPro was implanted in two directions: UltraPro Perpendicular (less stiff) and UltraPro Parallel (more stiff), with the indicated direction referring to the blue orientation lines. The mesh-vaginal complex (MVC) was excised en toto after 3 months. Main Outcome Measures Active mechanical properties were quantified as contractile force generated in the presence of 120 mM KCl. Passive mechanical properties (a tissues ability to resist an applied force) were measured using a multi-axial protocol. Results Vaginal contractility decreased 80% following implantation with the Gynemesh PS (p=0.001), 48% after SmartMesh (p=0.001), 68% after UltraPro parallel (p=0.001) and was highly variable after UltraPro perpendicular (p =0.16). The tissue contribution to the passive mechanical behavior of the MVC was drastically reduced for Gynemesh PS (p=0.003) but not SmartMesh (p=0.9) or UltraPro independent of the direction of implantation (p=0.68 and p=0.66, respectively). Conclusions Deterioration of the mechanical properties of the vagina was highest following implantation with the stiffest mesh, Gynemesh PS. Such a decrease associated with implantation of a device of increased stiffness is consistent with findings from other systems employing prostheses for support.

Feola, Andrew; Abramowitch, Steven; Jallah, Zegbeh; Stein, Suzan; Barone, William; Palcsey, Stacy; Moalli, Pamela

2012-01-01

160

Nonoxynol-9 berberine plural gel has little effect on expression of SLPI, SP-D and lactoferrin in mice's vagina.  

Science.gov (United States)

Background: The most frequently used spermicide Nonoxynol-9 (N-9) in the clinic alters the vaginal flora, which will result in an increased risk of opportunistic infection. So development of a novel spermicidal and microbicidal drug appears to be inevitable. Vaginal local immune is an important part of vaginal flora. Secretory leukocyte protease inhibitor (SLPI), surfactant proteins D (SP-D), and lactoferrin (LF) are anti-microbial molecules with important roles in immune system of female vaginas. Objective: To observe effect of a vaginal spermicide nonoxynol-9 (N-9) berberine plural gel on the expression of SLPI SP-D and LF in mice's vaginas. Materials and Methods : Female BABL/C mice were randomly divided into following 5 groups: normal control group, blank gel group, berberine gel group, 12% N-9 gel group and N-9 berberine plural gel group. Estradiol benzoate at physiological dose was done by hypodermic injection to every group's mice. After 72h, drug gels were separately injected into the mice's vaginas, while immunohistochemistry and Western blot were taken to detect the expression of the 3 indexes in mice's vaginas respectively after 24h and 72h of gel injection. Results: The differences in the three indexes between normal control group and blank gel group were not significant statistically (p>0.05). The expression of the three indexes in 12% N-9 gel group was decreased compared to that in blank gel group (p0.05). Also, the three index's level of 24h and 72h in sub observation groups after treatment were without statistical significance (p>0.05). Conclusion: Application of N-9 berberine plural gel had little impact on antimicrobial peptides in normal mice's vaginas. PMID:24639792

Yuan, Qiao; Zhuo, Chen; Yonggui, Ma; Fuer, Lu; Suhua, Chen; Guangying, Huang

2013-07-01

 
 
 
 
161

The oophorectomy effect on Walker 256 tumor inoculated into the vagina and uterine cervix of female rats Efeito da ooforectomia no tumor de Walker 256 inoculado em vagina e colo de útero de ratos fêmeas  

Directory of Open Access Journals (Sweden)

Full Text Available PURPOSE: Verify the effect of oophorectomy on the evolution of the Walker 256 tumor inoculated into the vagina and cervix of female rats. METHODS: Ten Wistar, female rats were used, distributed into two groups with 05 animals each: Tumor group (TG: Rats inoculated with Walker 256 tumor; Oophorectomy group (OG: oophorectomized rats inoculated with Walker 256 tumor. The day before the tumor vaginal inoculation, acetic acid was inoculated into the vaginas of both groups of rats; the following day, the vaginal walls were scarified with an endocervix brush, and then Walker 256 tumor was inoculated. After 12 days, the tumor was removed together with the vagina and uterine horns for macro and microscopic analyses. The data were submitted to statistical analyses. RESULTS: There was no statistical difference between the two groups; however it was observed that the behavior of tumor growth on the OG group presented greater invasion, compromising the uterine horns. CONCLUSION: The results of the study on the GO group presented a macroscopic behavior different from the TG group, however, both of them presented similar development in terms of tumor mass.OBJETIVO: Verificar o efeito da ooforectomia à inoculação do tumor de Walker 256 em vagina e colo de útero de ratas. MÉTODOS: Foram utilizadas 10 ratas Wistar, fêmeas, virgens, adultas, distribuídas em dois grupos de estudo com 05 animais cada: grupo tumor (GT: ratas inoculadas com tumor de Walker 256, e grupo Ooforectomia (GO: ratas ooforectomizadas e inoculadas com tumor de Walker 256. No dia anterior à inoculação vaginal do tumor, foram inoculados 0,3ml de ácido acético na vagina das ratas de ambos os grupos; no dia seguinte, foi realizada a escarificação da parede vaginal com uma escova de endocérvice e inoculado tumor de Walker 256. Após 12 dias, foi removido o tumor em bloco com vagina e cornos uterinos para análise macro e microscópica. Os dados foram submetidos à análise estatística. RESULTADOS: Não houve diferença estatística entre os dois grupos; no entanto, notou-se que o comportamento de crescimento do tumor no grupo GO apresentou maior invasividade em extensão, comprometendo cornos uterinos. CONCLUSÃO: Observou-se que o grupo GO apresentou comportamento macroscópico diferente ao grupo GT, no entanto, em termos totais de massa tumoral ambos apresentam desenvolvimento similar.

Nara Macedo Botelho Brito

2009-02-01

162

The oophorectomy effect on Walker 256 tumor inoculated into the vagina and uterine cervix of female rats / Efeito da ooforectomia no tumor de Walker 256 inoculado em vagina e colo de útero de ratos fêmeas  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: Verificar o efeito da ooforectomia à inoculação do tumor de Walker 256 em vagina e colo de útero de ratas. MÉTODOS: Foram utilizadas 10 ratas Wistar, fêmeas, virgens, adultas, distribuídas em dois grupos de estudo com 05 animais cada: grupo tumor (GT): ratas inoculadas com tumor de Walker [...] 256, e grupo Ooforectomia (GO): ratas ooforectomizadas e inoculadas com tumor de Walker 256. No dia anterior à inoculação vaginal do tumor, foram inoculados 0,3ml de ácido acético na vagina das ratas de ambos os grupos; no dia seguinte, foi realizada a escarificação da parede vaginal com uma escova de endocérvice e inoculado tumor de Walker 256. Após 12 dias, foi removido o tumor em bloco com vagina e cornos uterinos para análise macro e microscópica. Os dados foram submetidos à análise estatística. RESULTADOS: Não houve diferença estatística entre os dois grupos; no entanto, notou-se que o comportamento de crescimento do tumor no grupo GO apresentou maior invasividade em extensão, comprometendo cornos uterinos. CONCLUSÃO: Observou-se que o grupo GO apresentou comportamento macroscópico diferente ao grupo GT, no entanto, em termos totais de massa tumoral ambos apresentam desenvolvimento similar. Abstract in english PURPOSE: Verify the effect of oophorectomy on the evolution of the Walker 256 tumor inoculated into the vagina and cervix of female rats. METHODS: Ten Wistar, female rats were used, distributed into two groups with 05 animals each: Tumor group (TG): Rats inoculated with Walker 256 tumor; Oophorectom [...] y group (OG): oophorectomized rats inoculated with Walker 256 tumor. The day before the tumor vaginal inoculation, acetic acid was inoculated into the vaginas of both groups of rats; the following day, the vaginal walls were scarified with an endocervix brush, and then Walker 256 tumor was inoculated. After 12 days, the tumor was removed together with the vagina and uterine horns for macro and microscopic analyses. The data were submitted to statistical analyses. RESULTS: There was no statistical difference between the two groups; however it was observed that the behavior of tumor growth on the OG group presented greater invasion, compromising the uterine horns. CONCLUSION: The results of the study on the GO group presented a macroscopic behavior different from the TG group, however, both of them presented similar development in terms of tumor mass.

Brito, Nara Macedo Botelho; Carvalho, Rita de Kássia Vidigal; Matos, Lia Tavares de Moura Brasil; Lobato, Rodolfo Costa; Brito, Rosângela Baía.

163

Experimental inoculation model of Walker 256 carcinoma into vagina and cervix uteri of female rats Modelo experimental de Tumor de Walker 256 em vagina e colo de útero de ratas  

Directory of Open Access Journals (Sweden)

Full Text Available PURPOSE: To establish an inoculation model of Walker 256 carcinoma on cervix uteri and vagina of rats. METHODS: Fifteen female rats were used, and assigned to three groups each one with five rats: group A - rats with 4x10(6 cells of Walker 256 carcinoma without acid acetic inoculation; group B - rats with 2x10(6 cells of Walker 256 carcinoma with acid acetic inoculation and group C: rats with 4x10(6 cells of Walker 256 carcinoma with acid acetic inoculation. The day before tumor cells inoculation the rats from groups B and C were anaesthetized with diethylether and 0,3 ml of acetic acid was inoculated into their vaginas. Tumor cell inoculation into the vagina and cervix was done under general anesthesia with diethylether. Then a endocervical brush was used to scrape the vaginal wall and after that 0,3 ml of the liquid containing tumor cells was inoculated on the vagina and cervix. For the tumor analysis, animals were euthanized at day 12 following tumor cell implantation by an excessive inhalation of diethylether. Tumor was resected entirely and weighed and the tumors were then sectioned and counter stained with hematoxylin and eosin for histopathologic evaluation. It was also calculated the percentage of tumor equivalent to the body weight by the formula: P= tumor weight / body weight x 100. Data were analyzed by one-way analysis of variance - ANOVA. P values OBJETIVO: Estabelecer um modelo de inoculação de Tumor de Walker 256 em vagina e colo de útero de ratas. MÉTODOS: Foram utilizadas 15 ratas fêmeas, virgens, adultas, pesando entre 200-250g, distribuídas em três grupos de estudo com cinco animais cada: grupo A (GA: ratas com tumor de Walker 256 em concentração de 4x10(6 sem ácido acético; grupo B (GB: ratas com tumor de Walker 256 em concentração de 2x10(6 células com ácido acético; grupo C (GC: ratas com tumor de Walker 256 em concentração de 4x10(6 células com ácido acético. No dia anterior à inoculação do tumor, foi realizada a inoculação de 0,3 ml de ácido acético a 10% na vagina das ratas de GB e GC; no dia seguinte, tanto estas como as ratas do grupo GA foram anestesiadas, feita a escarificação da parede vaginal com uma escova de endocérvice e inoculado 0,3ml de tumor na concentração de 4x10(6 células nos grupos GA e GC e 2x10(6 células no grupo GB. Após 12 dias, foi realizada a eutanásia e removido o tumor em bloco com vagina e cornos uterinos para análise, sendo pesado e averiguado seu volume e calculado as relações entre o seu peso e o peso final da rata e o seu volume e o peso final da rata. Os dados foram colhidos e submetidos à análise estatística pelo método ANOVA (um critério. RESULTADOS: A pega em GB e GC foi 100% e em GA 20%. Não houve diferença estatística entre as médias obtidas entre GB e GC. CONCLUSÃO: De acordo com a metodologia utilizada, o modelo de tumor de Walker 256 na vagina apresenta pega de 100% quando associado a ácido acético e não há diferença de comportamento com a inoculação de 4x10(6ou 2x10(6 células.

Nara Macedo Botelho Brito

2007-12-01

164

Experimental inoculation model of Walker 256 carcinoma into vagina and cervix uteri of female rats / Modelo experimental de Tumor de Walker 256 em vagina e colo de útero de ratas  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: Estabelecer um modelo de inoculação de Tumor de Walker 256 em vagina e colo de útero de ratas. MÉTODOS: Foram utilizadas 15 ratas fêmeas, virgens, adultas, pesando entre 200-250g, distribuídas em três grupos de estudo com cinco animais cada: grupo A (GA): ratas com tumor de Walker 256 em c [...] oncentração de 4x10(6) sem ácido acético; grupo B (GB): ratas com tumor de Walker 256 em concentração de 2x10(6) células com ácido acético; grupo C (GC): ratas com tumor de Walker 256 em concentração de 4x10(6) células com ácido acético. No dia anterior à inoculação do tumor, foi realizada a inoculação de 0,3 ml de ácido acético a 10% na vagina das ratas de GB e GC; no dia seguinte, tanto estas como as ratas do grupo GA foram anestesiadas, feita a escarificação da parede vaginal com uma escova de endocérvice e inoculado 0,3ml de tumor na concentração de 4x10(6) células nos grupos GA e GC e 2x10(6) células no grupo GB. Após 12 dias, foi realizada a eutanásia e removido o tumor em bloco com vagina e cornos uterinos para análise, sendo pesado e averiguado seu volume e calculado as relações entre o seu peso e o peso final da rata e o seu volume e o peso final da rata. Os dados foram colhidos e submetidos à análise estatística pelo método ANOVA (um critério). RESULTADOS: A pega em GB e GC foi 100% e em GA 20%. Não houve diferença estatística entre as médias obtidas entre GB e GC. CONCLUSÃO: De acordo com a metodologia utilizada, o modelo de tumor de Walker 256 na vagina apresenta pega de 100% quando associado a ácido acético e não há diferença de comportamento com a inoculação de 4x10(6)ou 2x10(6) células. Abstract in english PURPOSE: To establish an inoculation model of Walker 256 carcinoma on cervix uteri and vagina of rats. METHODS: Fifteen female rats were used, and assigned to three groups each one with five rats: group A - rats with 4x10(6) cells of Walker 256 carcinoma without acid acetic inoculation; group B - ra [...] ts with 2x10(6) cells of Walker 256 carcinoma with acid acetic inoculation and group C: rats with 4x10(6) cells of Walker 256 carcinoma with acid acetic inoculation. The day before tumor cells inoculation the rats from groups B and C were anaesthetized with diethylether and 0,3 ml of acetic acid was inoculated into their vaginas. Tumor cell inoculation into the vagina and cervix was done under general anesthesia with diethylether. Then a endocervical brush was used to scrape the vaginal wall and after that 0,3 ml of the liquid containing tumor cells was inoculated on the vagina and cervix. For the tumor analysis, animals were euthanized at day 12 following tumor cell implantation by an excessive inhalation of diethylether. Tumor was resected entirely and weighed and the tumors were then sectioned and counter stained with hematoxylin and eosin for histopathologic evaluation. It was also calculated the percentage of tumor equivalent to the body weight by the formula: P= tumor weight / body weight x 100. Data were analyzed by one-way analysis of variance - ANOVA. P values

Brito, Nara Macedo Botelho; Brito, Marcus Vinicius Henriques; Carvalho, Rita de Kássia Vidigal; Matos, Lia Tavares de Moura Brasil; Veloso, Thiago Sousa; Vasconcelos, Diego Matos de; Brito, Rosângela Baía.

165

La vagina dentada: una interpretación de la Estela 25 de Izapa y las guacamayas del juego de pelota de Copán / The dented vagina: an interpretation for Stela 25 of Izapa and ballcourt macaws of Copan  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish Las aves representadas en la Estela 25 de Izapa y el juego de pelota de Copán forman el punto de partida para un examen del tema mitológico de la vagina dentada en Mesoamérica, y sus expresiones en el arte y la narrativa. Un amplio conjunto de narraciones mitológicas recopiladas en México y Guatemal [...] a sirve como base para un examen de la historia de Siete Guacamayo en el Popol Vuh, la cual se interpreta como una variante de un mito ampliamente difundido, relacionado con el origen del Sol y la Luna. La identificación de asuntos comunes, entre ellos el de la vagina dentada, refuerza la relación entre el mito del Popol Vuh y las representaciones de Izapa y Copán. A la vez, revela detalles poco conocidos sobre el simbolismo sexual presente en los mitos cosmogónicos mesoamericanos. Abstract in english The birds represented at Stela 25 of Izapa and Copan ball court are the starting point for the analysis of the mythological topic focused on the vagina dentata in Ancient Mesoamerica, as well as their expressions on art and narrative. A large body of mythological narratives is used as a basis for th [...] e examination of the "Siete Guacamayo" story included in the Popol Vuh, which is interpreted as part of a widely extended myth related with the creation of the Sun and the Moon. The identification of common issues, as the vagina dentata topic, strengthens the links between the Popol Vuh myth and the Izapa and Copan representations. It also reveals less known details on the sexual symbolism included in the Mesoamerican cosmogonic myths.

Oswaldo, Chinchilla Mazariegos.

166

La vagina dentada: una interpretación de la Estela 25 de Izapa y las guacamayas del juego de pelota de Copán The dented vagina: an interpretation for Stela 25 of Izapa and ballcourt macaws of Copan  

Directory of Open Access Journals (Sweden)

Full Text Available Las aves representadas en la Estela 25 de Izapa y el juego de pelota de Copán forman el punto de partida para un examen del tema mitológico de la vagina dentada en Mesoamérica, y sus expresiones en el arte y la narrativa. Un amplio conjunto de narraciones mitológicas recopiladas en México y Guatemala sirve como base para un examen de la historia de Siete Guacamayo en el Popol Vuh, la cual se interpreta como una variante de un mito ampliamente difundido, relacionado con el origen del Sol y la Luna. La identificación de asuntos comunes, entre ellos el de la vagina dentada, refuerza la relación entre el mito del Popol Vuh y las representaciones de Izapa y Copán. A la vez, revela detalles poco conocidos sobre el simbolismo sexual presente en los mitos cosmogónicos mesoamericanos.The birds represented at Stela 25 of Izapa and Copan ball court are the starting point for the analysis of the mythological topic focused on the vagina dentata in Ancient Mesoamerica, as well as their expressions on art and narrative. A large body of mythological narratives is used as a basis for the examination of the "Siete Guacamayo" story included in the Popol Vuh, which is interpreted as part of a widely extended myth related with the creation of the Sun and the Moon. The identification of common issues, as the vagina dentata topic, strengthens the links between the Popol Vuh myth and the Izapa and Copan representations. It also reveals less known details on the sexual symbolism included in the Mesoamerican cosmogonic myths.

Oswaldo Chinchilla Mazariegos

2010-01-01

167

Avaliação dosimétrica de uma combinação de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porção distal da vagina Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJETIVO: Avaliar uma alternativa de braquiterapia para tumores do colo uterino acometendo a porção distal da vagina, sem aumentar os riscos de toxicidade. MATERIAIS E MÉTODOS: Estudo teórico comparando três diferentes aplicadores de braquiterapia intracavitária de alta taxa de dose: sonda intrauterina e cilindro vaginal (SC); sonda e anel associado ao cilindro vaginal (SA+C) e um aplicador virtual com sonda, anel e cilindro vaginal em um único conjunto (SAC). Foram prescritas doses de...

2009-01-01

168

Factors affecting long-term outcome of irradiation in carcinoma of the vagina  

International Nuclear Information System (INIS)

Objective: This report evaluates prognostic and technical factors affecting outcome of patients with primary carcinoma of the vagina treated with definitive radiation therapy. Methods and Materials: A retrospective analysis was performed on records of 212 patients with histologically confirmed carcinoma of the vagina treated with irradiation. Results: Tumor stage was the most significant prognostic factor; actuarial 10-year disease-free survival was 94% for Stage 0 (20 patients), 80% for Stage I (59 patients), 55% for Stage IIA (63 patients), 35% for Stage IIB (34 patients), 38% for Stage III (20 patients), and 0% for Stage IV (15 patients). All in situ lesions except one were controlled with intracavitary therapy. Of the patients with Stage I disease, 86% showed no evidence of vaginal or pelvic recurrence; most of them received interstitial or intracavitary therapy or both, and the addition of external-beam irradiation did not significantly increase survival or tumor control. In Stage IIA (paravaginal extension) and IIB (parametrial involvement) 66% and 56% of the tumors, respectively, were controlled with a combination of brachytherapy and external-beam irradiation; 13 of 20 (65%) Stage III tumors were controlled in the pelvis. Four patients with Stage IV disease (27%) had no recurrence in the pelvis. The total incidence of distant metastases was 13% in Stage I, 30% in Stage IIA, 52% in Stage IIB, 50% in Stage III, and 47% in Stage IV. The dose of irradiation delivered to the primary tumor or the parametrial extension was of relative importance in achieving successful results. In patients with Stage I disease, brachytherapy alone achieved the same local tumor control (80-100%) as in patients receiving external pelvic irradiation (78-100%) as well. In Stage II and III there was a trend toward better tumor control (57-80%) with combined external irradiation and brachytherapy than with the latter alone (33-50%) (p = 0.42). The incidence of grade 2-3 complications (12%) correlated with the stage of the tumor and type of treatment given. Conclusion: Radiation therapy is an effective treatment for patients with vaginal carcinoma, particularly Stage I. More effective irradiation techniques, including optimization of dose distribution combining external irradiation and interstitial brachytherapy in tumors beyond Stage I, are necessary to enhance locoregional tumor control. The high incidence of distant metastases emphasizes the need for earlier diagnosis and effective systemic cytotoxic agents to improve survival in these patients

1999-04-01

169

A primary amelanotic melanoma of the vagina, diagnosed by immunohistochemical staining with HMB-45, which recurred as a pigmented melanoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Usually, malignant melanoma is readily diagnosed by the presence of melanin granules. Although amelanotic melanoma contains a few melanin granules, it is often difficult to differentiate from non-epithelial malignant tumours. This report describes a case of amelanotic melanoma of the vagina, which was originally suspected to be a non-epithelial malignant tumour, but was subsequently correctly diagnosed by immunohistochemical staining with the HMB-45 antibody and for the S-100 protein. A light...

Oguri, H.; Izumiya, C.; Maeda, N.; Fukaya, T.; Moriki, T.

2004-01-01

170

Ultrastructural study of the neovagina following the utilization of human amniotic membrane for treatment of congenital absence of the vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We present an ultrastructural study of the utilization of human amniotic membrane in the treatment of congenital absence of the vagina in 10 patients. All patients were surgically treated with application of an amniotic membrane graft using the modified McIndoe and Bannister technique. Sixty days after surgery, samples of the vaginal neo-epithelium were collected for transmission electron microscopy analysis. The ultrastructural findings consisted of a lining of mature squamous epithelium ind...

1997-01-01

171

Topometric preparation and interstitial gamma-therapy of patients with recurrencies and metastases of uterine cancer to the vagina  

International Nuclear Information System (INIS)

The developed technique of preradiation topometry in patients with recurrencies and metastases of uterine cancer to the vagina allows to visualize boundaries of soft-tissue tumor formation and to specify its localization, sizes and relation with urethra, rectum, urinary bladder. Results of topometric investigation are used for individual planning of interstitial radiotherapy: fabrication of fixing instruments, choice of a number of sources, their activity, position, and exposure duration

1984-01-01

172

The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina) – phenotypic manifestations and genetic approaches  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome affects at least 1 out of 4500 women and has for a long time been considered as a sporadic anomaly. Congenital absence of upper vagina and uterus is the prime feature of the disease which, in addition, is often found associated with unilateral renal agenesis or adysplasia as well as skeletal malformations (MURCS association). The phenotypic manifestations of MRKH overlap various other syndromes or associations and thus req...

Guerrier Daniel; Mouchel Thomas; Pasquier Laurent; Pellerin Isabelle

2006-01-01

173

The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina) – phenotypic manifestations and genetic approaches  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome affects at least 1 out of 4500 women and has for a long time been considered as a sporadic anomaly. Congenital absence of upper vagina and uterus is the prime feature of the disease which, in addition, is often found associated with unilateral renal agenesis or adysplasia as well as skeletal malformations (MURCS association). The phenotypic manifestations of MRKH overlap various other syndromes or associations and thus require accurate delin...

Guerrier, Daniel; Mouchel, Thomas; Pasquier, Laurent; Pellerin, Isabelle

2006-01-01

174

Citologia Hormonal do Trato Urinário Baixo e da Vagina de Mulheres na Pós-menopausa, antes e durante Estrogenioterapia Oral e Transdérmica  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objetivo: avaliar a ação dos estrogênios por via oral ou transdérmica nas células do trato urinário baixo e da vagina, em mulheres menopausadas. Métodos: foram incluídas 25 mulheres na pós-menopausa, nas quais se estudaram os efeitos citológicos da terapia de reposição hormonal estrogênica, por via oral e por via transdérmica, sobre as células da vagina e do sedimento urinário. As pacientes foram distribuídas aleatoriamente em 2 grupos: Grupo I, constituído por 14 mulheres q...

2002-01-01

175

Paraganglioma of the vagina: a case report and review of the literature  

Directory of Open Access Journals (Sweden)

Full Text Available Tao Cai,1 Yucong Li,2 Qingming Jiang,3 Dong Wang,2 Yu Huang2 1Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, 2Department of Gynecologic Oncology, 3Department of Pathology, Chongqing Cancer Research Institute, Chongqing, People’s Republic of China Abstract: Vaginal paraganglioma is a rare and unusual tumor occurring in the vaginal wall. It is a solitary primary paraganglioma, especially in atypical sites. Herein, we report an unusual case of a 17-year-old woman who had not experienced vomiting, or hypertension. She was found to have an immobile solid mass in the right side of her vaginal wall. Positron emission tomography/computed tomography scans revealed a well-defined solid ovoid mass adjacent to the bladder and pelvic floor. Tumor markers were within the normal range. A transient blood pressure increase occurred during the biopsy. After oral administration of antihypertensive drugs, surgery was performed to completely remove the mass. Histopathological examination indicated that it was a paraganglioma of the vagina. Repeat computed tomography examination did not reveal any local recurrence or distant metastasis during the 12-month follow-up period. Keywords: vaginal paraganglioma, neuroendocrine tumor, clinical features, treatment

Cai T

2014-06-01

176

Squamous carcinoma of the vagina: treatment, complications, and long-term follow-up  

International Nuclear Information System (INIS)

Seventy-five cases of primary squamous cell carcinoma of the vagina treated at the University of Pennsylvania are reviewed with long-term follow-up presented. These comprised 2.5% of all female genital malignancies treated during 1958 to 1980 inclusive. Patients treated during that time with non-squamous cell cancers have been excluded. Patients are analyzed with regard to stage, therapy, complications, and survival. Sixty-five percent of patients were stage I or II. Five-year survival for the entire group was 45%. Patients treated with radical surgery other than exenteration did well, with 7 of 8 surviving 5 years. Serious treatment complications were mostly related to radiation therapy and primarily involved the bowel and bladder. Three patients died of complications. Recurrence carried a grave prognosis as 30 of 33 patients with recurrence died of disease. Most recurrences were diagnosed within the first year following treatment. Patients with advanced disease were more likely to have distant recurrences. Although radiation therapy is generally the treatment of choice, radical surgery can yield excellent results when used in carefully selected patients. With meticulous attention to radiation dosage and technique it is hoped that treatment morbidity can be reduced. Optimal treatment of advanced disease may require some form of adjuvant systemic therapy

1985-01-01

177

Phospholipase activity of Candida albicans isolated from vagina and urine samples  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction and objective: Candida albicans is the most virulent among the Candida species, and can cause several forms of candidiasis in human. Extracellular phospholipases in C. albicans is discussed as one of the virulence factors. The present study, focused on extracellular phospholipase activities in different isolates of C. albicans isolated from vagina and urine samples from Ahvaz, Iran. In addition, phospholipase activities were compared in C. albicans isolated from two different sources. Materials and methods: In the present study, phospholipase activity of 100 isolates of C. albicans with urine and vaginitis origin was demonstrated using Sabouraud's dextrose agar supplemented with egg yolk. Results: The phospholipase activity was detected in all tested isolates with a high level in Pz<0.70. In the present study phospholipase activity with higher Pz values was more common in vaginal isolates (84.7% isolates with Pz value <0.70 compared with 75% in urine isolates. Conclusion: In the present study, 100% clinical isolates of C. albicans from vaginitis and urine samples demonstrated phospholipase activity.

Sanaz Miry

2010-10-01

178

Entrenamiento de carneros para recolección de semen mediante vagina artificial, utilizando como estímulo objetos inanimados  

Directory of Open Access Journals (Sweden)

Full Text Available Con el fi n de desarrollar una metodología para entrenar carneros en la recolección de semen con vagina artifi cial (VA, montando un objeto inanimado, se utilizaron nueve animales que se sometieron a cuatro etapas de preparación. La primera con el propósito de lograr la manifestación del repertorio sexual natural, y el resto para llevar a cabo un programa de condicionamiento operante: cuando la respuesta correcta (monta sucedía, en un inicio provocada por un estado de motivación sexual, se daba un refuerzo positivo o estímulo incondicionado (eyaculación, con lo que eventualmente y mediante un proceso de generalización la respuesta condicionada (primero montar a una hembra que no estaba en celo y luego a un objeto inanimado se aprendió como la respuesta correcta. Al inicio de cada fase 33%-55% de los carneros no eyacularon; sin embargo, al fi nal de las fases 1-3, todos eyacularon al menos una vez, al fi nal del entrenamiento fue imposible recolectar semen de un macho. Se concluye que mediante la metodología propuesta 90% de los machos jóvenes pueden ser entrenados para montar objetos inanimados con el fi n de recolectar semen mediante VA.

Virginio Aguirre Flores

2005-01-01

179

Recurrent paediatric pinworm infection of the vagina as a potential reservoir for Enterobius vermicularis.  

Science.gov (United States)

Enterobius vermicularis infection remains one of the most common parasitic infections, particularly prevalent in children. Enterobiasis, although not usually dangerous, may cause significant morbidity. Elimination of the parasite from a family or an institution often poses problems, either because of an incomplete cure or re-infection. While there have been limited reports of ectopic enterobiasis throughout the world, ours is probably one of the rarest reports of recurrent vaginal E. vermicularis infection in the absence of any gastrointestinal symptoms despite complete treatment. A 4-year-old girl presented with recurrent episodes of vulval itching on 3-4 occasions over 2 years. There was no pruritis ani nor urinary/gastrointestinal complaints. The vulva was inflamed with 4-5 living worms, 6-7 mm in length, emerging from the anterior vaginal fornix, but with no vaginal discharge. Direct microscopic examination of vaginal swabs revealed adult worms of Enterobius but no eggs. Repeated stool samples from the patient, parents and a sibling were negative. The patient was treated orally with 100 mg of mebendazole for 3 days followed by two more courses at 3-week intervals over a period of 3 months. Recurrent vaginal enterobiasis despite complete treatment and in the absence of any gastrointestinal involvement suggests that the vagina is a potential reservoir for E. vermicularis, which supports the theory of rare ectopic enterobiasis through the ascending pathway of the female genital tract. PMID:23721910

Kashyap, B; Samantray, J C; Kumar, S; Jhamb, R; Singh, A K; Kaur, I R

2013-05-31

180

Impact of pregnancy and vaginal delivery on the passive and active mechanics of the rat vagina.  

Science.gov (United States)

Remodeling of vaginal extracellular matrix and smooth muscle likely plays a critical role in reducing the risk of maternal injury during vaginal delivery by altering the mechanical properties to increase distension and reduce stress. Long-Evans rats were divided into five groups to examine the passive mechanical and active contractile properties throughout pregnancy and postpartum: virgin (n=17), mid-pregnant (Day 14-16, n=12), late-pregnant (Day 20-22, n=14), immediate postpartum (0-2 h after delivery, n=14), and 4 week postpartum (n=15). Longitudinal sections of vaginal tissue were loaded to failure uniaxially for passive mechanical or active contractile properties were examined. For passive mechanics, the tangent modulus decreased 45% by mid-pregnancy and immediately postpartum (p<0.001). The ultimate strain continuously increased up to 43% higher than virgin animals (p=0.007) in the immediate postpartum group. For active mechanics, the maximal contractile force was 36-56% lower through immediate postpartum animals, and was significantly more sensitive to K+ throughout pregnancy and postpartum (p=0.003). The changes observed in the passive and active properties of the rat vagina are consistent with what would be expected from a tissue that is remodeling to maximize its ability to distend at the time of vaginal delivery to facilitate passage of the fetus with minimal injury. PMID:20824342

Feola, Andrew; Moalli, Pamela; Alperin, Marianna; Duerr, Robbie; Gandley, Robin E; Abramowitch, Steven

2011-01-01

 
 
 
 
181

Antibiotic resistance in Staphylococci isolated from the vaginas of captive female Leontopithecus (Callitrichidae-Primates).  

Science.gov (United States)

The purpose of this study was to provide current data on Staphylococcus species from the vaginas of clinically normal captive lion tamarins and to determine the antimicrobial susceptibility of these isolates. Samples were collected from 25 adult lion tamarins, processed to isolate Staphylococcus species, and tested for susceptibility to penicillin G, gentamicin, chloramphenicol, tetracycline, trimethoprim-sulfamethoxazole, streptomycin, ampicillin, and rifampicin. Isolates with the typical characteristics of the genus Staphylococcus were recovered from all 25 samples. Coagulase-negative species were the most common (68% of the isolates), and the most frequently isolated species (10 samples) was S. simulans. Other coagulase-negative species, including S. saprophyticus (n=5), S. epidermidis (n=1), and S. arlettae (n=1), were also recovered. Coagulase-positive Staphylococci were obtained from eight animals (six of from the S. aureus species and two from S. intermedius). Resistance to antibiotics was frequently observed, and 88% of the isolates (23 samples) showed resistance to at least one drug. Resistance to penicillin G was a common finding, and the most active antimicrobial agents were chloramphenicol and gentamicin. Coagulase-positive strains were more frequently resistant to antibiotics (79.7%, average=6.4 drugs) than coagulase-negative strains (38.2%, average=3.0 drugs). The high frequency of resistance observed in those isolates is surprising and very alarming. A detailed history of the use of antimicrobial drugs in these subjects did not reveal any previous exposure to any of the tested antibiotics that could justify the observed resistance rate. PMID:16847975

Lilenbaum, Walter; Moraes, Ismar A; Cardoso, Verônica S; Varges, Renato G; Ferreira, Ana Maria R; Pissinatti, Alcides

2006-08-01

182

Absorption and disposition of econazole nitrate after application to the skins and vaginas of rabbits.  

Science.gov (United States)

1. The absorption and tissue distribution of radioactivity has been studied in rabbits after application of a cream containing 10 mg of the 3H-labelled 1-(2,4-dichloro-beta-[(p-chlorobenzyl)oxy]phenethyl) imidazole nitrate (econazole nitrate, Pevaryl) to the normal or abraded skins of rabbits. 2. Approximately one-third of the dose was absorbed through the occluded normal skins of rabbits during 8 days, mainly during 7 to 24 h. In the same time interval, slightly more of the dose was absorbed through the occluded abraded skins of rabbits at slightly greater rates. Co-formulation of triamcinolone acetonide in the cream reduced and delayed the peak rates of absorption through normal and abraded skin, but the extent of absorption during 8 days was similar in the presence or absence of triamcinolone acetonide. 3. After application to normal skin or abraded skin, the peak of mean concentrations in the plasma of 220 ng/ml (range 132-276 ng/ml) or 307 ng/ml (range 270-321 ng/ml), respectively, occurred at 24 h. Tissue distribution of radioactivity was similar after application to normal or abraded skin, and concentrations were highest in the liver, kidneys and gastrointestinal tract (which are the organs of biotransformation and excretion) and also in the adrenals and to a lesser extent in the uterus, ovaries and untreated skin. 4. After application of a cream containing 5 mg of 3H-econazole nitrate to the vaginas of rabbits, approximately one-third of the dose was absorbed during 8-24 h, and rates of excretion were higher through the more permeable vaginal membrane. 5. After vaginal doses of 5 mg, a peak concentration of 209 ng/ml occurred at 6 h in the plasma. Tissue concentrations of radioactivity after vaginal doses were highest in liver, kidneys, gastrointestinal tract, adrenals and ovaries, and the tissue distribution was similar to that observed after cutaneous doses. PMID:1037247

Cameron, B D; Chasseaud, L F; Conway, B; Fox, N; Taylor, T

1976-01-01

183

Functional anatomy of the vagina muscles in the adult western conifer seed bug, Leptoglossus occidentalis (Heteroptera: Coreidae), and its implication for the egg laying behaviour in insects.  

Science.gov (United States)

The anatomy of the female reproductive tract and the nerve-evoked contractions of the vagina muscles and their association with the ovipositor in the western conifer seed bug, Leptoglossus occidentalis (Heidemann) are investigated for the first time. The reproductive tract consists of a set of paired telotrophic ovaries, each containing seven ovarioles, located in the anterior lateral regions of the abdomen. Each ovary is attached to a lateral oviduct which spans most of the abdomen to attach to a relatively short common oviduct that joins the vagina near the rear of the animal. The vagina is associated with a pair of bilaterally symmetrical muscles attached at their posterior ends to lateral extensions of sternite VIII, the valvifer of the Type II ovipositor. From this attachment site, the muscles fan out medially and anteriorly to converge along the dorsal midline of the vagina up to the base of the common oviduct. Vagina muscles respond to a single stimulation of their motor nerves by producing a smooth contraction lasting approximately 1 s. With increasing frequencies of stimulation, the muscle contractions summate to create a tetanic response. The muscles are fatigue resistant being able to maintain the same degree of tension for up to 10 min at 10 Hz stimulation. Visual observation shows that other muscles associated with the valves of the ovipositor behave in a similar fashion to that of the vagina muscles from which the tension recordings were obtained. Fatigue-resistant vagina muscles are discussed in relation to copulation, sperm transport and this insect's ability to deposit a series of eggs directly onto the surface of a conifer needle in a manner by which eight or more blunt-ended eggs are packed end-to-end in a single row. PMID:20172047

Chiang, R G

2010-07-01

184

xpression of estrogen and progesterone receptor genes in endometrium, myometrium and vagina of postmenopausal women treated with estriol / Expresión de los genes receptores de estrógeno y progesterona en el endometrio, miometrio y vagina en mujeres posmenopáusicas tratadas con estriol  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in spanish CONTEXTO Y OBJETIVO: El estriol es un estrógeno con un efecto estimulatorio bastante más débil sobre la proliferación endometrial que el estradiol. Se realizó un estudio para determinar los efectos de una terapia vaginal de 14 días con estriol, sobre el nivel de receptores de estrógeno (ER) y recept [...] ores de progesterona (PR), comparado con mujeres sin esa terapia. La expresión de los genes de ER y PR se analizó en el endometrio, miometrio y vagina de mujeres posmenopáusicas tratadas con estriol. DISEÑO Y UBICACIÓN: Estudio Transversal analítico, en el Instituto de Investigación del Hospital de la Madre Polaca en Lodz, Polonia. MÉTODOS: Se incluyeron veintisiete mujeres posmenopáusicas (de 57 a 74 años) en el estudio. Todas ellas estaban en espera de una histerectomía per vaginam o de cirugía plástica de la vagina y del perineo debido a un prolapso del útero. La expresión de genes de los receptores ER y PR se estableció por la técnica de RT-PCR. RESULTS: En las pacientes tratadas con estriol en comparación con el grupo de control, se observó un aumento significativo de la expresión del gen de ER en el endometrio y la vagina, mientras que un aumento de la expresión del gen de PR se encontró en el endometrio. De todas formas, en el examen histológico del endometrio, se diagnosticó estimulación estrogénica de bajo y medio grado en el 21.4% y en el 14.3% de las mujeres tratadas con estriol, respectivamente. CONCLUSIONES: Los resultados obtenidos sugieren que un tratamiento de 14 días con estriol en pacientes, aunque aumentan el nivel de ER y de PR mRNA, tiene muy poco o ningún efecto sobre la proliferación endometrial. Abstract in english CONTEXT AND OBJECTIVE: Estriol is an estrogen with considerably weaker stimulatory effects on endometrial proliferation than estradiol. A study was conducted to determine the level of estrogen receptors (ERs) and progesterone receptors (PRs) in women who received 14-day vaginal estriol therapy, comp [...] ared with those who did not receive this therapy. ER and PR gene expression was analyzed in the endometrium, myometrium and vagina of postmenopausal women treated with estriol. DESIGN AND SETTING: Analytical cross-sectional study, at the Research Institute of the Polish Mothers' Memorial Hospital, Lodz, Poland. METHODS: Twenty-seven postmenopausal women (57-74 years of age) were included in the study. All of them were waiting for per vaginam hysterectomy or plastic surgery on the vagina and perineum because of uterine prolapse. ER and PR gene expression was determined by means of the technique of reverse transcription polymerase chain reaction (RT-PCR). RESULTS: In the estriol-treated patients, in comparison with the control group, a significant increase in ER gene expression was observed in the endometrium and vagina, while enhanced PR gene expression was found in the endometrium. However, under histological examination of the endometrium, estrogen stimulation of low and medium degree was diagnosed for 21.4% and 14.3% of the estriol-treated women, respectively. CONCLUSION: The results obtained suggest that the women who received 14 days of treatment with vaginal estriol had higher ER and PR mRNA levels. No difference between these groups regarding endometrial proliferation was observed.

Magdalena, Bry& #347; ; Krzysztof, Szytto; Hanna, Romanowicz-Makowska; Zbigniew, Dobrowolski; Izabela, Mastowska; Wanda, Krajewska.

185

Experimental inoculation model of Walker 256 carcinoma into vagina and cervix uteri of female rats Modelo experimental de Tumor de Walker 256 em vagina e colo de útero de ratas  

Digital Repository Infrastructure Vision for European Research (DRIVER)

PURPOSE: To establish an inoculation model of Walker 256 carcinoma on cervix uteri and vagina of rats. METHODS: Fifteen female rats were used, and assigned to three groups each one with five rats: group A - rats with 4x10(6) cells of Walker 256 carcinoma without acid acetic inoculation; group B - rats with 2x10(6) cells of Walker 256 carcinoma with acid acetic inoculation and group C: rats with 4x10(6) cells of Walker 256 carcinoma with acid acetic inoculation. The day before tumor cells inoc...

Nara Macedo Botelho Brito; Marcus Vinicius Henriques Brito; Rita de Kássia Vidigal Carvalho; Lia Tavares de Moura Brasil Matos; Thiago Sousa Veloso; Diego Matos de Vasconcelos; Rosângela Baía Brito

2007-01-01

186

Avaliação dosimétrica de uma combinação de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porção distal da vagina Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVO: Avaliar uma alternativa de braquiterapia para tumores do colo uterino acometendo a porção distal da vagina, sem aumentar os riscos de toxicidade. MATERIAIS E MÉTODOS: Estudo teórico comparando três diferentes aplicadores de braquiterapia intracavitária de alta taxa de dose: sonda intrauterina e cilindro vaginal (SC; sonda e anel associado ao cilindro vaginal (SA+C e um aplicador virtual com sonda, anel e cilindro vaginal em um único conjunto (SAC. Foram prescritas doses de 7 Gy no ponto A e 5 Gy na superfície ou a 5 mm de profundidade na mucosa vaginal, mantendo as doses nos pontos de reto, bexiga e sigmoide abaixo dos limites de tolerância. Foram comparados os volumes englobados pelas isodoses de 50% (V50, 100% (V100, 150% (V150 e 200% (V200, respectivamente. RESULTADOS: Tanto SA+C quanto SAC apresentaram melhor distribuição de dose quando comparados ao aplicador SC. A distribuição de dose obtida com SA+C foi semelhante à do aplicador SAC, sendo V150 e V200 cerca de 50% maiores para SA+C, todavia, dentro do cilindro. CONCLUSÃO: A utilização de SA+C em uma única aplicação em dois tempos pode ser uma alternativa de tratamento para pacientes que apresentam tumores de colo uterino com acometimento distal da vagina.OBJECTIVE: To evaluate an alternative brachytherapy technique for uterine cervix cancer involving the distal vagina, without increasing the risk of toxicity. MATERIALS AND METHODS: Theoretical study comparing three different high-dose rate intracavitary brachytherapy applicators: intrauterine tandem and vaginal cylinder (TC; tandem/ring applicator combined with vaginal cylinder (TR+C; and a virtual applicator combining both the tandem/ring and vaginal cylinder in a single device (TRC. Prescribed doses were 7 Gy at point A, and 5 Gy on the surface or at a 5 mm depth of the vaginal mucosa. Doses delivered to the rectum, bladder and sigmoid colon were kept below the tolerance limits. Volumes covered by the isodoses, respectively, 50% (V50, 100% (V100, 150% (V150 and 200% (V200 were compared. RESULTS: Both the combined TR+C and TRC presented a better dose distribution as compared with the TC applicator. The TR+C dose distribution was similar to the TRC dose, with V150 and V200 being about 50% higher for TR+C (within the cylinder. CONCLUSION: Combined TR+C in a two-time single application may represent an alternative therapy technique for patients affected by uterine cervix cancer involving the distal vagina.

Roger Guilherme Rodrigues Guimarães

2009-08-01

187

Avaliação dosimétrica de uma combinação de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porção distal da vagina / Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Avaliar uma alternativa de braquiterapia para tumores do colo uterino acometendo a porção distal da vagina, sem aumentar os riscos de toxicidade. MATERIAIS E MÉTODOS: Estudo teórico comparando três diferentes aplicadores de braquiterapia intracavitária de alta taxa de dose: sonda intrauter [...] ina e cilindro vaginal (SC); sonda e anel associado ao cilindro vaginal (SA+C) e um aplicador virtual com sonda, anel e cilindro vaginal em um único conjunto (SAC). Foram prescritas doses de 7 Gy no ponto A e 5 Gy na superfície ou a 5 mm de profundidade na mucosa vaginal, mantendo as doses nos pontos de reto, bexiga e sigmoide abaixo dos limites de tolerância. Foram comparados os volumes englobados pelas isodoses de 50% (V50), 100% (V100), 150% (V150) e 200% (V200), respectivamente. RESULTADOS: Tanto SA+C quanto SAC apresentaram melhor distribuição de dose quando comparados ao aplicador SC. A distribuição de dose obtida com SA+C foi semelhante à do aplicador SAC, sendo V150 e V200 cerca de 50% maiores para SA+C, todavia, dentro do cilindro. CONCLUSÃO: A utilização de SA+C em uma única aplicação em dois tempos pode ser uma alternativa de tratamento para pacientes que apresentam tumores de colo uterino com acometimento distal da vagina. Abstract in english OBJECTIVE: To evaluate an alternative brachytherapy technique for uterine cervix cancer involving the distal vagina, without increasing the risk of toxicity. MATERIALS AND METHODS: Theoretical study comparing three different high-dose rate intracavitary brachytherapy applicators: intrauterine tandem [...] and vaginal cylinder (TC); tandem/ring applicator combined with vaginal cylinder (TR+C); and a virtual applicator combining both the tandem/ring and vaginal cylinder in a single device (TRC). Prescribed doses were 7 Gy at point A, and 5 Gy on the surface or at a 5 mm depth of the vaginal mucosa. Doses delivered to the rectum, bladder and sigmoid colon were kept below the tolerance limits. Volumes covered by the isodoses, respectively, 50% (V50), 100% (V100), 150% (V150) and 200% (V200) were compared. RESULTS: Both the combined TR+C and TRC presented a better dose distribution as compared with the TC applicator. The TR+C dose distribution was similar to the TRC dose, with V150 and V200 being about 50% higher for TR+C (within the cylinder). CONCLUSION: Combined TR+C in a two-time single application may represent an alternative therapy technique for patients affected by uterine cervix cancer involving the distal vagina.

Roger Guilherme Rodrigues, Guimarães; Heloisa de Andrade, Carvalho; Silvia Radwanski, Stuart; Rodrigo Augusto, Rubo; Rodrigo Migotto, Seraide.

188

Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina.  

Science.gov (United States)

The objective of this study was to determine whether stromal and/or epithelial relaxin receptor (LGR7) is required for relaxin to promote proliferation and inhibit apoptosis of stromal and epithelial cells in the mouse cervix and vagina. Tissue recombinants were prepared with stroma (St) and epithelium (Ep) from wild-type (wt) and LGR7 knockout (ko) mice: wt-St+wt-Ep, wt-St+ko-Ep, ko-St+wt-Ep, and ko-St+ko-Ep. Tissue recombinants were grafted under the renal capsule of intact syngeneic female mice. After 3 wk of transplant growth, hosts were ovariectomized and fitted with silicon implants containing progesterone and estradiol-17beta (designated d 1 of treatment). Animals were injected sc with relaxin or relaxin vehicle PBS at 6-h intervals from 0600 h on d 8 through 0600 h on d 10 of treatment. To evaluate cell proliferation, 5-bromo-2'-deoxyuridine was injected sc 10 h before cervices and vaginas were collected at 1000 h on d 10. Terminal deoxynucleotidyl transferase-mediated deoxyuridine 5'-triphosphate nick end labeling was used to quantify apoptosis. Relaxin markedly increased proliferation and decreased apoptosis of epithelial and stromal cells in tissue recombinants containing wt stroma (P < 0.01) but had no effect on tissue recombinants prepared with ko stroma, regardless of whether epithelium was derived from wt or ko mice. In conclusion, this study shows that LGR7-expressing cells in the stroma are both necessary and sufficient for relaxin to promote proliferation and inhibit apoptosis in both stromal and epithelial cells of cervix and vagina, whereas epithelial LGR7 does not affect these processes. PMID:18218691

Yao, LiJuan; Agoulnik, Alexander I; Cooke, Paul S; Meling, Daryl D; Sherwood, O David

2008-05-01

189

Genital sanguineous discharge in prepuberty: a case of mullerian papilloma of vagina in a nine-year-old girl.  

Science.gov (United States)

Vaginal bleeding in prepuberty is an alarming symptom that must be carefully investigated. Among quite common causes of genital sanguineous discharge, there are rarer conditions responsible for bleeding at this age like Mullerian papilloma of the genital tract. In this report, we describe a case of Mullerian papilloma of the vagina in a 9-year-old girl. We believe in the importance of a correct clinical setting and histological definition to avoid wrong diagnosis and consequent inadequate treatments. Mullerian papilloma, a benign tumor, can in fact be treated only with local excision. PMID:21073126

Tumini, Stefano; Carinci, Silvia; Anzellotti, Maria Teresa; Chiesa, Pier Luigi Lelli; Rossi, Carlo; Stuppia, Liborio; Bertelloni, Silvano; Chiarelli, Francesco

2010-08-01

190

Normal tissue reactions to high dose-rate intracavitary irradiation of the vagina with different fractionation schedules and dose levels  

International Nuclear Information System (INIS)

The radiation reactions in the normal tissues of the vagina, rectum and bladder were studied in 166 patients receiving prophylactic vaginal high dose-rate intracavitary irradiation. Most reactions were observed in the vaginal mucosa included in the intracavitary target and only a few in the rectum and bladder in close proximity to the same target. The influence of the total dose, the dose per fraction and the overall treatment time, summarized as the Cumulative Radiation Effect (CRE), correlated well to the rate of reactions after a correction of the formula for late effects. (orig.)

1985-03-01

191

Vulvovaginectomy and neo-urethrostomy for the treatment of haemangiosarcoma of the vulva and vagina : case report  

Directory of Open Access Journals (Sweden)

Full Text Available Vulvovaginectomy and neo-urethrostomy were performed in a 9-year-old German shepherd dog following a diagnosis of infiltrative vulvar and vestibulovaginal haemangiosarcoma. The dog was presented for intermittent vulvar haemorrhage over a 3-month period. On examination the vulva and vestibulovagina were distended and firm. Vaginal discharge and fine needle aspiration cytology detected anaplastic cells. Haemangiosarcoma was diagnosed on biopsy. A new urethral opening was created in the floor of the vagina allowing resection of the vulva and caudal vestibulovagina. Urinary continence was preserved and healing was without complications.

T.P. Hill

2012-07-01

192

Relaxin Acts on Stromal Cells to Promote Epithelial and Stromal Proliferation and Inhibit Apoptosis in the Mouse Cervix and Vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The objective of this study was to determine whether stromal and/or epithelial relaxin receptor (LGR7) is required for relaxin to promote proliferation and inhibit apoptosis of stromal and epithelial cells in the mouse cervix and vagina. Tissue recombinants were prepared with stroma (St) and epithelium (Ep) from wild-type (wt) and LGR7 knockout (ko) mice: wt-St+wt-Ep, wt-St+ko-Ep, ko-St+wt-Ep, and ko-St+ko-Ep. Tissue recombinants were grafted under the renal capsule of intact syngeneic female...

Yao, Lijuan; Agoulnik, Alexander I.; Cooke, Paul S.; Meling, Daryl D.; Sherwood, O. David

2008-01-01

193

Clinico-radiobiological evaluation of the correlation between dose and injury rate in radiotherapy of endometrial metastases into the vagina  

International Nuclear Information System (INIS)

Problem of choosing optimum radiobiological model is studied for prediction of the probability of arising radiation-induced complications in case of radiotherapy of patients of corpus uteri carcinoma with metastases into the vagina. Based on the results of radiotherapy (remote plus contact; contact) at different doses the radiobiological modes time dose-fractionation factor is found to be usable in case of radiobiological assesment of various dose fractionation variants and choice of isoeffective regimes under clinical conditions. It is easy in case and makes it possible to predict truly the probability of arising early and late radiation-induced complication

1999-01-01

194

Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina; Avaliacao dosimetrica de uma combinacao de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porcao distal da vagina  

Energy Technology Data Exchange (ETDEWEB)

Objective: To evaluate an alternative brachytherapy technique for uterine cervix cancer involving the distal vagina, without increasing the risk of toxicity. Materials And Methods: Theoretical study comparing three different high-dose rate intracavitary brachytherapy applicators: intrauterine tandem and vaginal cylinder (TC); tandem/ring applicator combined with vaginal cylinder (TR+C); and a virtual applicator combining both the tandem/ring and vaginal cylinder in a single device (TRC). Prescribed doses were 7 Gy at point A, and 5 Gy on the surface or at a 5 mm depth of the vaginal mucosa. Doses delivered to the rectum, bladder and sigmoid colon were kept below the tolerance limits. Volumes covered by the isodoses, respectively, 50% (V50), 100% (V100), 150% (V150) and 200% (V200) were compared. Results: Both the combined TR+C and TRC presented a better dose distribution as compared with the TC applicator. The TR+C dose distribution was similar to the TRC dose, with V150 and V200 being about 50% higher for TR+C (within the cylinder). Conclusion: Combined TR+C in a two-time single application may represent an alternative therapy technique for patients affected by uterine cervix cancer involving the distal vagina. (author)

Guimaraes, Roger Guilherme Rodrigues [Real e Benemerita Sociedade Portuguesa de Beneficencia, Sao Paulo, SP (Brazil). Servico de Radioterapia Estereotactica; Carvalho, Heloisa de Andrade; Stuart, Silvia Radwanski; Rubo, Rodrigo Augusto [Universidade de Sao Paulo (USP), SP (Brazil). Hospital das Clinicas. Servico de Radioterapia], e-mail: handrade@hcnet.usp.br; Seraide, Rodrigo Migotto [Centro de Oncologia Campinas, SP (Brazil)

2009-07-15

195

Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina  

International Nuclear Information System (INIS)

Objective: To evaluate an alternative brachytherapy technique for uterine cervix cancer involving the distal vagina, without increasing the risk of toxicity. Materials And Methods: Theoretical study comparing three different high-dose rate intracavitary brachytherapy applicators: intrauterine tandem and vaginal cylinder (TC); tandem/ring applicator combined with vaginal cylinder (TR+C); and a virtual applicator combining both the tandem/ring and vaginal cylinder in a single device (TRC). Prescribed doses were 7 Gy at point A, and 5 Gy on the surface or at a 5 mm depth of the vaginal mucosa. Doses delivered to the rectum, bladder and sigmoid colon were kept below the tolerance limits. Volumes covered by the isodoses, respectively, 50% (V50), 100% (V100), 150% (V150) and 200% (V200) were compared. Results: Both the combined TR+C and TRC presented a better dose distribution as compared with the TC applicator. The TR+C dose distribution was similar to the TRC dose, with V150 and V200 being about 50% higher for TR+C (within the cylinder). Conclusion: Combined TR+C in a two-time single application may represent an alternative therapy technique for patients affected by uterine cervix cancer involving the distal vagina. (author)

2009-01-01

196

Study of uterine prolapse by magnetic resonance imaging: topographical changes involving the levator ani muscle and the vagina.  

Science.gov (United States)

Alternations of the pelvic structure with an emphasis on those of the levator ani muscle, associated with uterine prolapse, were studied using sagittal magnetic resonance images obtained from 19 subjects without and 14 with uterine or vaginal prolapse of varied degree and 3 patients with Rokitansky syndrome who had undergone a McIndoe operation. Two additional patients with a grade III uterine prolapse were also studied before and 2-3 months after corrective surgery consisting of vaginal hysterectomy combined with anterior colporrhaphy and posterior colpoperineorrhaphy. Absence or presence of prolapse, irrespective of its grade, was found to be related to whether or not a reference line extrapolated from the levator plate crossed the pubis on sagittal images. This was the case as well in patients with Rokitansky syndrome with a neovagina and loss of such crossings was restored in patients with prolapse after surgery. Backward bending of the upper vagina noted in nonprolapse conditions was usually absent in patients with uterine prolapse. These results document that topographical changes involving the levator ani muscle and the vagina occur in association with uterine prolapse. PMID:1526530

Ozasa, H; Mori, T; Togashi, K

1992-01-01

197

Definitive radiotherapy for carcinoma of the vagina: outcome and prognostic factors  

International Nuclear Information System (INIS)

Purpose: Primary carcinoma of the vagina is an uncommon tumor. Because of the long-standing interest in this disease at our institution a substantial number of patients with this disease has been accumulated, and this retrospective review was performed to define disease outcome, to delineate significant prognostic factors, and to provide treatment guidelines. Methods and Materials: This was a retrospective review of 301 patients with vaginal carcinoma (271 with squamous cell and 30 with adenocarcinoma) who received definitive radiotherapy between 1953 and 1991. Prognostic factors for outcome (local control, pelvic control, metastatic relapse, survival, and complications) were evaluated using univariate and multivariate techniques. Results: Patients disease was staged using the International Federation of Gynecology and Obstetrics (FIGO) system, and stages were distributed as follows: 0, 37 (12%); I, 65 (22%); II, 122 (40%); III, 60 (20%); and, IVA, 17 (6%). Treatment varied according to stage, with brachytherapy predominating for early disease but external beam playing a prominent role for more advanced disease. Patients with in situ disease received brachytherapy alone or transvaginal orthovoltage irradiation. For Stage I, brachytherapy alone was used in 25, external beam and brachytherapy in 38, and transvaginal alone in 2. For Stage II, brachytherapy alone was used in 20, external and brachytherapy in 66, and external irradiation alone in 36. For Stage III, external and brachytherapy was used in 15, and external alone in 45. Two patients with Stage IVA received brachytherapy alone, 10 received a combination of external and brachytherapy, and 6 received external irradiation alone. Total doses ranged from 10 to 154 Gy (mean 74.7 Gy, median 70.0 Gy), but only 18 (6%) received less than 55 Gy. At a median follow-up of 13 years, the 5-, 10-, 15-, 20-, and 25-year survival rates were 60%, 49%, 38%, 29%, and 23%, respectively. Beyond 5 years the survival rates relative to those for age-matched females in the general population were between 50 and 65%. Actuarial local recurrence rates were 23%, 26%, and 26% at 5, 10, and 15 years. Actuarial pelvic relapse rates were 26%, 30%, and 31% at 5, 10, and 15 years, and metastatic rates at those times were 15%, 18%, and 18%. Adenocarcinoma (nonclear cell) was a significantly worse disease than squamous cell carcinoma. The major determinants of local control for squamous carcinoma were tumor bulk (specified by size in centimeters, or by FIGO stage), tumor site (upper lesions faring better than others), and tumor circumferential location (lesions involving the posterior wall faring worse). Tumor bulk was an important determinant of metastatic relapse, but failure to achieve local control was also an independently significant determinant of metastases. Salvage after first relapse was uncommon and the survival rate at 5 years after relapse was only 12%. Serious complications occurred in 39 patients with an actuarial incidence of 19% at 20 years. Conclusion: Vaginal carcinoma poses a formidable therapeutic challenge. The disease is heterogeneous with respect to its prognostic factors. Nonclear cell adenocarcinoma has an extremely poor prognosis and should be distinguished from squamous carcinoma. Both external beam and brachytherapy play crucial roles in management and most patients with disease beyond in situ should receive a significant component of external irradiation prior to brachytherapy

1996-07-15

198

Disturbances in the vagina development of the white rat off spring under the effect of X-ray irradiation  

International Nuclear Information System (INIS)

120 embryos of white rats from 13 to 22 days old irradiated with X-rays at 12-th-14-th days of embryogenesis. The embryos are classified in the series of sagittal, transversal, frontal cross sections and are dyed with conVentional techniques. The formation of paramesonefral tracts is obserVed in all experimental animals. The violations of the vaginal development manifest themselves in the time delay of connection of paramesonefral tracts resorption of medial partition between connected tracts, separation of the sinus vaginal part from the genitourinary sinus, recanalization of vaginal epithelial band. More serious injuries are presented by agenesis of the sinus part of vagina and atresia of the organ in the form of its transverse separation by a partition

1983-01-01

199

Genital panics: Constructing the vagina in women's qualitative narratives about pubic hair, menstrual sex, and vaginal self-image.  

Science.gov (United States)

An emerging body of research targets women's relationship to their genitals, particularly as pubic hair removal and the promotion of female genital surgeries increase in popularity and visibility. This study asked women to discuss their subjective feelings about three related but distinct genital attitudes: pubic hair grooming, sex during menstruation, and genital/vaginal self-image. Specifically, this study applied thematic analysis to qualitative interviews with a community sample of 20 women (mean age=34, SD=13.35) from diverse ages, races, and sexual identity backgrounds to illuminate seven themes in women's narratives about their vaginas: (1) "dirty" or "gross"; (2) needing maintenance; (3) unknown or frustrating; (4) unnatural; (5) comparative; (6) ambivalent; (7) affirmative. Overwhelmingly, women used strong emotional language when discussing their genitals, often evoking descriptions of anxiety, excess, and need for control. Fusions between sexuality and body image, and connections between "genital panics" and internalized racism, sexism, and homophobia, also appeared. PMID:24958655

Fahs, Breanne

2014-06-01

200

Ultrastructural Features of Vagina at Different Phases of the Oestrous Cycle in the Female African Giant Rat (Cricetomys gambianus Waterhouse).  

Science.gov (United States)

The ultrastructures of the vagina at various stages of the oestrous cycle in female African giant rats (Cricetomys gambianus Waterhouse) were described in the present study. At mid-proestrus, late proestrus (LP)/early estrus (EE) and mid-estrus (ME) as well as late metestrus (LM)/early diestrus (ED) and mid-diestrus (MD), complex interface of epithelium and lamina propria were observed. Cells of the stratum basale formed finger-like extensions into the underlying lamina propria and tips of the extensions displayed hemidesmosome while basal lamina followed the contour of the extensions. At mid-metestrus (MM) and late diestrus/early proestrus, well developed, relatively straight basal lamina interfaced between the stratum basale and the lamina propria without finger-like projections. Polygonal cells with indented nuclei and, cytoplasm containing ribosomes, polysomes, intermediate filaments, and mitochondria were observed in stratum spinosum at all the phases of the oestrus cycle. At MM, LM/ED, and MD, the stratum spinosum had numerous desmosomes with tonofilaments, large microvilli that intermingled at the intercellular spaces and evidence of trapped/migrating neutrophils and lymphocytes. The superficial layer displayed short microvilli at mid-proestrus, cornification at LP/EE and desquamation at ME while it showed condensation of intermediate filaments; projections of large microvilli into the luminal surface at MM, and embeddement of neutrophils at LM/ED as well as MD. This study looked into the reproductive biology of female African giant rats to produce baseline information on its reproductive organs and represented the first comprehensive description of the vagina at the ultrastructural level during oestrous cycle. Anat Rec, 297:1131-1136, 2014. © 2014 Wiley Periodicals, Inc. PMID:24737725

Akinloye, Adebayo K; Oke, Bankole O

2014-06-01

 
 
 
 
201

Nonoxynol-9 berberine plural gel has little effect on expression of SLPI, SP-D and lactoferrin in mice’s vagina  

Directory of Open Access Journals (Sweden)

Full Text Available Background: The most frequently used spermicide Nonoxynol-9 (N-9 in the clinic alters the vaginal flora, which will result in an increased risk of opportunistic infection. So development of a novel spermicidal and microbicidal drug appears to be inevitable. Vaginal local immune is an important part of vaginal flora. Secretory leukocyte protease inhibitor (SLPI, surfactant proteins D (SP-D, and lactoferrin (LF are anti-microbial molecules with important roles in immune system of female vaginas. Objective: To observe effect of a vaginal spermicide nonoxynol-9 (N-9 berberine plural gel on the expression of SLPI SP-D and LF in mice’s vaginas. Materials and Methods: Female BABL/C mice were randomly divided into following 5 groups: normal control group, blank gel group, berberine gel group, 12% N-9 gel group and N-9 berberine plural gel group. Estradiol benzoate at physiological dose was done by hypodermic injection to every group’s mice. After 72h, drug gels were separately injected into the mice’s vaginas, while immunohistochemistry and Western blot were taken to detect the expression of the 3 indexes in mice’s vaginas respectively after 24h and 72h of gel injection. Results: The differences in the three indexes between normal control group and blank gel group were not significant statistically (p>0.05. The expression of the three indexes in 12% N-9 gel group was decreased compared to that in blank gel group (p0.05. Also, the three index's level of 24h and 72h in sub observation groups after treatment were without statistical significance (p>0.05. Conclusion: Application of N-9 berberine plural gel had little impact on antimicrobial peptides in normal mice’s vaginas.

Huang Guangying

2013-01-01

202

Caracterização de leveduras isoladas da vagina e sua associação com candidíase vulvovaginal em duas cidades do sul do Brasil Characterization of yeasts isolated from the vagina and their association with vulvovaginal candidíasis in two cities of the South of Brazil  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVOS: avaliar a distribuição de espécies de leveduras isoladas da vagina em duas localidades do sul do Brasil e comparar o perfil de suscetibilidade in vitro destas leveduras a antifúngicos usados na prática clínica. MÉTODOS: todas as mulheres atendidas entre janeiro e junho de 2004 para exames rotineiros de amostras vaginais, independente de serem sintomáticas ou não, foram incluídas neste estudo. Foram excluídas as que apresentavam imunodeficiências como AIDS ou outras infecções genitais. Amostras de conteúdo vaginal dessas mulheres (Jaraguá do Sul - SC (n=130 e Maringá - PR (n=97 foram cultivadas. As leveduras isoladas foram identificadas e submetidas ao teste de suscetibilidade aos antifúngicos fluconazol, nistatina e anfotericina B. RESULTADOS: a freqüência de cultura positiva para levedura foi semelhante nas duas localidades, aproximadamente 24%. Candida albicans foi a espécie prevalente, mas sua freqüência diferiu: em SC correspondeu a 77,4% das leveduras e foi a mais freqüente tanto nas mulheres sintomáticas quanto nas assintomáticas. Já no PR foi 50,0%, com predomínio mais evidente nos casos sintomáticos. Observamos altos índices de suscetibilidade ao fluconazol e anfotericina B, porém 51,1% das leveduras apresentaram suscetibilidade dependente da dose (S-DD para nistatina. C. albicans mostrou maior tendência de resistência à nistatina (52,8% de S-DD do que as espécies não-albicans (44,4%. CONCLUSÕES: nossos dados mostram diferenças regionais quanto à espécie de levedura em amostras vaginais. Sugerem que a determinação da espécie pode ter implicação clínica, considerando as diferenças quanto à suscetibilidade, principalmente à nistatina, e que poderiam ter importância no manejo da candidíase vulvovaginal.PURPOSE: to evaluate the distribution of yeast species isolated from the vagina in two cities of the South of Brazil and compare the in vitro susceptibility profile of these yeasts against some antifungals, which are used in clinical routine. METHODS: all women attended from January to June 2004 for vaginal routine examinations, independent of being symptomatic or not were included in the study. Only those who presented immunodeficiency like AIDS or any other genital infection were excluded. Samples of vaginal discharge from the women (Jaraguá do Sul - SC (n=130 and Maringá - PR (n=97 were cultivated. The yeasts were identified and submitted to the susceptibility test against the antifungals fluconazole, nystatin and amphotericin B. RESULTS: the frequency of positive cultures for yeasts was the same in both cities; C. albicans was the most prevalent species (about 24%, but its frequency was different: in SC it corresponded to 77.4% of the yeasts both in symptomatic and asymptomatic women and in PR it was 50.0% with predominance in symptomatic women. We observed high rates of susceptibility to fluconazole and amphotericin B, but 51.1% of the yeasts presented dose-dependent susceptibility (DDS to nystatin. C. albicans showed a higher tendency to be nystatin resistant (52.8% DDS than non-albicans species (44.4%. CONCLUSIONS: our data showed geographic differences among the species of yeasts isolated from the vagina and suggest that this fact has clinical relevance considering the differences in susceptibility, especially regarding nystatin, which could be important for the management of vulvovaginal candidiasis.

Magda Helena S. H. Ferrazza

2005-02-01

203

Caracterização de leveduras isoladas da vagina e sua associação com candidíase vulvovaginal em duas cidades do sul do Brasil / Characterization of yeasts isolated from the vagina and their association with vulvovaginal candidíasis in two cities of the South of Brazil  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVOS: avaliar a distribuição de espécies de leveduras isoladas da vagina em duas localidades do sul do Brasil e comparar o perfil de suscetibilidade in vitro destas leveduras a antifúngicos usados na prática clínica. MÉTODOS: todas as mulheres atendidas entre janeiro e junho de 2004 para exames [...] rotineiros de amostras vaginais, independente de serem sintomáticas ou não, foram incluídas neste estudo. Foram excluídas as que apresentavam imunodeficiências como AIDS ou outras infecções genitais. Amostras de conteúdo vaginal dessas mulheres (Jaraguá do Sul - SC (n=130) e Maringá - PR (n=97)) foram cultivadas. As leveduras isoladas foram identificadas e submetidas ao teste de suscetibilidade aos antifúngicos fluconazol, nistatina e anfotericina B. RESULTADOS: a freqüência de cultura positiva para levedura foi semelhante nas duas localidades, aproximadamente 24%. Candida albicans foi a espécie prevalente, mas sua freqüência diferiu: em SC correspondeu a 77,4% das leveduras e foi a mais freqüente tanto nas mulheres sintomáticas quanto nas assintomáticas. Já no PR foi 50,0%, com predomínio mais evidente nos casos sintomáticos. Observamos altos índices de suscetibilidade ao fluconazol e anfotericina B, porém 51,1% das leveduras apresentaram suscetibilidade dependente da dose (S-DD) para nistatina. C. albicans mostrou maior tendência de resistência à nistatina (52,8% de S-DD) do que as espécies não-albicans (44,4%). CONCLUSÕES: nossos dados mostram diferenças regionais quanto à espécie de levedura em amostras vaginais. Sugerem que a determinação da espécie pode ter implicação clínica, considerando as diferenças quanto à suscetibilidade, principalmente à nistatina, e que poderiam ter importância no manejo da candidíase vulvovaginal. Abstract in english PURPOSE: to evaluate the distribution of yeast species isolated from the vagina in two cities of the South of Brazil and compare the in vitro susceptibility profile of these yeasts against some antifungals, which are used in clinical routine. METHODS: all women attended from January to June 2004 for [...] vaginal routine examinations, independent of being symptomatic or not were included in the study. Only those who presented immunodeficiency like AIDS or any other genital infection were excluded. Samples of vaginal discharge from the women (Jaraguá do Sul - SC (n=130) and Maringá - PR (n=97)) were cultivated. The yeasts were identified and submitted to the susceptibility test against the antifungals fluconazole, nystatin and amphotericin B. RESULTS: the frequency of positive cultures for yeasts was the same in both cities; C. albicans was the most prevalent species (about 24%), but its frequency was different: in SC it corresponded to 77.4% of the yeasts both in symptomatic and asymptomatic women and in PR it was 50.0% with predominance in symptomatic women. We observed high rates of susceptibility to fluconazole and amphotericin B, but 51.1% of the yeasts presented dose-dependent susceptibility (DDS) to nystatin. C. albicans showed a higher tendency to be nystatin resistant (52.8% DDS) than non-albicans species (44.4%). CONCLUSIONS: our data showed geographic differences among the species of yeasts isolated from the vagina and suggest that this fact has clinical relevance considering the differences in susceptibility, especially regarding nystatin, which could be important for the management of vulvovaginal candidiasis.

Magda Helena S. H., Ferrazza; Márcia L. Ferrarezi, Maluf; Marcia Edilaine Lopes, Consolaro; Cristiane Suemi, Shinobu; Terezinha Inez Estivalet, Svidzinski; Márcia Regina, Batista.

204

Qualitative and semiquantitative analysis of Lactobacillus species in the vaginas of healthy fertile and postmenopausal Chinese women.  

Science.gov (United States)

The present study aimed to investigate the prevalence and quantity of Lactobacillus species in the vaginas of healthy Chinese women. Vaginal samples from 92 fertile and 22 postmenopausal healthy Chinese women were analysed using a 16S rRNA gene clone library and species-specific PCR followed by sequencing and real-time PCR. A total of 13 different Lactobacillus species were detected. Species-specific PCR showed that 3% of the fertile women were colonized by one species of Lactobacillus and 97% were colonized by two or more species. Among the postmenopausal women, 91% were colonized by one species of Lactobacillus and 9% were colonized by two species. In the fertile women, L. iners (82.61%), L. crispatus (70.65%) and L. gasseri (67.39%) were more prevalent than L. jensenii (40.22%), L. acidophilus (39.13%), L. brevis (23.91%), L. plantarum (5.43%), L. johnsonii (3.26%), L. fermentum (2.17%), L. salivarius (2.17%), L. rhamnosus (1.09%), L. reuteri (1.09%) and L. paracasei (1.09%); L. delbrueckii was not detected. In the postmenopausal women, L. fermentum, L. rhamnosus, L. reuteri and L. delbrueckii were not detected, and the other 10 species were detected in just a few samples. The prevalence of these species according to the clone library differed from the prevalence indicated by the species-specific PCR. According to the semiquantitative analysis, the total Lactobacillus DNA concentrations were higher in fertile women than in postmenopausal women. Sixty-one per cent of the fertile women were predominantly colonized by L. iners, 35% by L. crispatus, and 2% by L. gasseri. Associations between pairs of Lactobacillus species in fertile women were significant (Pgasseri, L. iners and L. jensenii, L. iners and L. acidophilus, L. gasseri and L. acidophilus, and L. gasseri and L. jensenii. In conclusion, this study provided detailed information on Lactobacillus species colonizing the vaginas of healthy Chinese fertile and postmenopausal women. The study also showed that the diversity of Lactobacillus species in fertile women was higher than in postmenopausal women. According to our study, different techniques, such as species-specific PCR and comparison against a 16S rRNA gene clone library, resulted in different findings regarding species prevalence. These findings highlight the importance of standardization of techniques used for evaluation of bacterial communities. According to our findings regarding species associations, L. iners and L. gasseri may have influences on colonization and proliferation of other vaginal Lactobacillus species. PMID:22301614

Zhang, Rui; Daroczy, Katalin; Xiao, Bingbing; Yu, Li; Chen, Rui; Liao, Qinping

2012-05-01

205

Immunoglobulin G, Plasma Cells, and Lymphocytes in the Murine Vagina after Vaginal or Parenteral Immunization with Attenuated Herpes Simplex Virus Type 2  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This investigation evaluated immunity to vaginal herpes simplex virus type 2 (HSV-2) infection after local or parenteral immunization with attenuated HSV-2. Vaginal immunization induced sterilizing immunity against challenge with a high dose of wild-type virus, whereas parenteral immunizations protected against neurologic disease but did not entirely prevent infection of the vagina. Vaginal immunization caused 86- and 31-fold increases in the numbers of immunoglobulin G (IgG) plasma cells in ...

Parr, Earl L.; Parr, Margaret B.

1998-01-01

206

Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background: Most studies of the vaginal microflora have been based on culture or on qualitative molecular techniques. Here we applied existing real-time PCR formats for Lactobacillus crispatus, L. gasseri and Gardnerella vaginalis and developed new formats for Atopobium vaginae, L. iners and L. jensenii to obtain a quantitative non culture-based determination of these species in 71 vaginal samples from 32 pregnant and 28 non-pregnant women aged between 18 and 45 years. Results: The 71 vagi...

Backer, Ellen; Verhelst, Rita; Verstraelen, Hans; Alqumber, Ma; Burton, Jp; Tagg, Jr; Temmerman, Marleen; Vaneechoutte, Mario

2007-01-01

207

Detection of hydrogen peroxide-producing Lactobacillus species in the vagina: a comparison of culture and quantitative PCR among HIV-1 seropositive women  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background The presence of hydrogen peroxide (H2O2) producing Lactobacillus in the vagina may play a role in controlling genital HIV-1 shedding. Sensitive molecular methods improve our ability to characterize the vaginal microbiota; however, they cannot characterize phenotype. We assessed the concordance of H2O2-producing Lactobacillus detected by culture with quantitative PCR (qPCR) detection of Lacto...

Balkus Jennifer E; Mitchell Caroline; Agnew Kathy; Liu Congzhou; Fiedler Tina; Cohn Susan E; Luque Amneris; Coombs Robert; Fredricks David N; Hitti Jane

2012-01-01

208

Characterisation of the bacterial microbiota of the vagina of dairy cows and isolation of pediocin-producing Pediococcus acidilactici  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Uterine infections in dairy cows lower profitability of dairy operations. Infections of the reproductive tract are related to the overgrowth of pathogenic bacteria during the first three weeks after parturition. However, alterations in the vaginal microbiota composition in the first weeks after parturition remain poorly documented. Results In this study, bacteria isolated from the vagina of healthy pregnant, and infected postpartum cows were ...

Wang Yvonne; Ametaj Burim N; Ambrose Divakar J; Gänzle Michael G

2013-01-01

209

Persistence of Lactobacillus fermentum RC-14 and Lactobacillus rhamnosus GR-1 but Not L. rhamnosus GG in the Human Vagina as Demonstrated by Randomly Amplified Polymorphic DNA  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 are well-characterized probiotic strains with efficacy in the prevention and treatment of urogenital infections in women. The aim of the present study was to apply a molecular biology-based methodology for the detection of these strains and L. rhamnosus GG (a commercially available intestinal probiotic) in the human vagina in order to assess probiotic persistence at this site. Ten healthy women inserted vaginally a capsule containing either ...

Gardiner, Gillian E.; Heinemann, Christine; Bruce, Andrew W.; Beuerman, Dee; Reid, Gregor

2002-01-01

210

Citologia Hormonal do Trato Urinário Baixo e da Vagina de Mulheres na Pós-menopausa, antes e durante Estrogenioterapia Oral e Transdérmica Urinary and Vaginal Cytology of Postmenopausal Women with Oral and Transdermal Estrogen Replacement  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objetivo: avaliar a ação dos estrogênios por via oral ou transdérmica nas células do trato urinário baixo e da vagina, em mulheres menopausadas. Métodos: foram incluídas 25 mulheres na pós-menopausa, nas quais se estudaram os efeitos citológicos da terapia de reposição hormonal estrogênica, por via oral e por via transdérmica, sobre as células da vagina e do sedimento urinário. As pacientes foram distribuídas aleatoriamente em 2 grupos: Grupo I, constituído por 14 mulheres q...

2002-01-01

211

In silico vs in vitro analysis of primer specificity for the detection of Gardnerella vaginalis, Atopobium vaginae and Lactobacillus spp.  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Bacterial vaginosis (BV is a common pathology of women in reproductive age that can lead to serious health complications, and is associated with shifts in the normal microflora from predominance of Lactobacillus spp. to a proliferation of other anaerobes such as G. vaginalis and A vaginae, which can be detected by PCR. The optimal PCR pathogen detection assay relies mainly on the specificity and sensitivity of the primers used. Findings Here we demonstrate that in silico analytical testing of primer specificity is not a synonym to in vitro analytical specificity by testing a range of published and newly designed primers with both techniques for the detection of BV-associated microorganisms. Conclusions By testing primer in vitro specificity with a sufficient range of bacterial strains, we were able to design primers with higher specificity and sensitivity. Also by comparing the results obtained for the newly designed primers with other previously published primers, we confirmed that in silico analysis is not sufficient to predict in vitro specificity. As such care must be taken when choosing the primers for a detection assay.

Henriques Ana

2012-11-01

212

The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina – phenotypic manifestations and genetic approaches  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract The Mayer-Rokitansky-Küster-Hauser (MRKH syndrome affects at least 1 out of 4500 women and has for a long time been considered as a sporadic anomaly. Congenital absence of upper vagina and uterus is the prime feature of the disease which, in addition, is often found associated with unilateral renal agenesis or adysplasia as well as skeletal malformations (MURCS association. The phenotypic manifestations of MRKH overlap various other syndromes or associations and thus require accurate delineation. Since MRKH manifests itself in males, the term GRES syndrome (Genital, Renal, Ear, Skeletal might be more appropriate when applied to both sexes. The MRKH syndrome, when described in familial aggregates, seems to be transmitted as an autosomal dominant trait with an incomplete degree of penetrance and variable expressivity. This suggests the involvement of either mutations in a major developmental gene or a limited chromosomal deletion. Until recently progress in understanding the genetics of MRKH syndrome has been slow, however, now HOX genes have been shown to play key roles in body patterning and organogenesis, and in particular during genital tract development. Expression and/or function defects of one or several HOX genes may account for this syndrome.

Pasquier Laurent

2006-01-01

213

The Mayer-Rokitansky-K?ster-Hauser syndrome (congenital absence of uterus and vagina) - phenotypic manifestations and genetic approaches  

Science.gov (United States)

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome affects at least 1 out of 4500 women and has for a long time been considered as a sporadic anomaly. Congenital absence of upper vagina and uterus is the prime feature of the disease which, in addition, is often found associated with unilateral renal agenesis or adysplasia as well as skeletal malformations (MURCS association). The phenotypic manifestations of MRKH overlap various other syndromes or associations and thus require accurate delineation. Since MRKH manifests itself in males, the term GRES syndrome (Genital, Renal, Ear, Skeletal) might be more appropriate when applied to both sexes. The MRKH syndrome, when described in familial aggregates, seems to be transmitted as an autosomal dominant trait with an incomplete degree of penetrance and variable expressivity. This suggests the involvement of either mutations in a major developmental gene or a limited chromosomal deletion. Until recently progress in understanding the genetics of MRKH syndrome has been slow, however, now HOX genes have been shown to play key roles in body patterning and organogenesis, and in particular during genital tract development. Expression and/or function defects of one or several HOX genes may account for this syndrome.

Guerrier, Daniel; Mouchel, Thomas; Pasquier, Laurent; Pellerin, Isabelle

2006-01-01

214

Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Most studies of the vaginal microflora have been based on culture or on qualitative molecular techniques. Here we applied existing real-time PCR formats for Lactobacillus crispatus, L. gasseri and Gardnerella vaginalis and developed new formats for Atopobium vaginae, L. iners and L. jensenii to obtain a quantitative non culture-based determination of these species in 71 vaginal samples from 32 pregnant and 28 non-pregnant women aged between 18 and 45 years. Results The 71 vaginal microflora samples of these women were categorized, using the Ison and Hay criteria, as refined by Verhelst et al. (2005, as follows: grade Ia: 8 samples, grade Iab: 10, grade Ib: 13, grade I-like: 10, grade II: 11, grade III: 12 and grade IV: 7. L. crispatus was found in all but 5 samples and was the most frequent Lactobacillus species detected. A significantly lower concentration of L. crispatus was found in grades II (p L. jensenii was found in all grades but showed higher concentration in grade Iab than in grade Ia (p = 0.024. A. vaginae and G. vaginalis were present in high concentrations in grade III, with log10 median concentrations (log10 MC, respectively of 9.0 and 9.2 cells/ml. Twenty (38.5% of the 52 G. vaginalis positive samples were also positive for A. vaginae. In grade II we found almost no L. iners (log10 MC: 0/ml but a high concentration of L. gasseri (log10 MC: 8.7/ml. By contrast, in grade III we found a high concentration of L. iners (log10 MC: 8.3/ml and a low concentration of L. gasseri (log10 MC: 0/ml. These results show a negative association between L. gasseri and L. iners (r = -0.397, p = 0.001 and between L. gasseri and A. vaginae (r = -0.408, p Conclusion In our study we found a clear negative association between L. iners and L. gasseri and between A. vaginae and L. gasseri. Our results do not provide support for the generally held proposition that grade II is an intermediate stage between grades I and III, because L. gasseri, abundant in grade II is not predominant in grade III, whereas L. iners, abundant in grade III is present only in low numbers in grade II samples.

Tagg John R

2007-12-01

215

The use of konjac glucomannan hydrolysates to recover healthy microbiota in infected vaginas treated with an antifungal agent.  

Science.gov (United States)

The aim of this study was to evaluate how konjac glucomannan hydrolysates (GMH) could support the healthy re-colonisation of vaginal microflora post infections. A total of 26 female patients (12 controls and 14 treatments) aged 18 to 25 suffering from vaginal infection were recruited for this study. Patients were assigned randomly into two groups to receive a standard antifungal treatment or a standard antifungal treatment plus pessary capsules containing 200 mg GMH (twice a week for thirty days). Patients were assessed on day zero, sixteen and thirty of the trial. Several parameters were determined including yeast and bacterial counts, the KOH test, pH, Gram staining and wet mount microscopic observations. The results showed that the counts of Candida were diminished completely with antifungal treatment for both groups. However, the total bacterial counts increased with time in the GMH pessary group unlike the control. The normalised average KOH scores were reduced sharply with time in both groups although in the control group scores started to increase after sixteen days. The normalised average white blood cell scores also decreased with time for both groups. Epithelial cell scores decreased only for the GMH pessary group while clue cells and yeast-like fungi decreased with time for both control and GMH pessary groups. These results indicate the improvement of vaginal health recovery (post antifungal treatment for Candida infection) and especially the presence of healthy microflora due to the introduction of GMH in the vagina. The data indicate that it would be worth examining further the health benefits of GMH in a vaginal health format with a view to employing the material as a prophylactic or therapeutic agent. It provides an alternative approach to reducing vaginal infections and promoting consumer health. PMID:22348910

Tester, R; Al-Ghazzewi, F; Shen, N; Chen, Z; Chen, F; Yang, J; Zhang, D; Tang, M

2012-03-01

216

HOXA10 and HOXA13 sequence variations in human female genital malformations including congenital absence of the uterus and vagina.  

Science.gov (United States)

Congenital genital malformations occurring in the female population are estimated to be 5 per 1000 and associate with infertility, abortion, stillbirth, preterm delivery and other organ abnormalities. Complete aplasia of the uterus, cervix and upper vagina (Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome) has an incidence of 1 per 4000 female live births. The molecular etiology of congenital genital malformations including MRKH is unknown up to date. The homeobox (HOX) genes HOXA10 and HOXA13 are involved in the development of human genitalia. In this investigation, HOXA10 and HOXA13 genes of 20 patients with the MRKH syndrome, 7 non-MRKH patients with genital malformations and 53 control women were sequenced to assess for DNA variations. A total of 14 DNA sequence variations (10 novel and 4 known) within exonic and untranslated regions were detected in HOXA10 and HOXA13 among our cohorts. Four HOXA10 and two HOXA13 DNA sequence variations were found solely in patients with genital malformations. In addition to mutations resulting in synonymous amino acid substitutions, in the HOXA10 gene a missense mutation was identified and predicted by computer analysis as probably damaging to protein function in two non-MRKH patients, one with a bicornate and the other patient with a septated uterus. A novel exonic HOXA10 cytosine deletion was also identified in a non-MRKH patient with a septate uterus and renal malformations resulting in a premature stop codon and loss of the homeodomain helix 3/4. This cytosine deletion and the missense mutation in HOXA10 were analysed by real time PCR and sequencing, respectively, in two additional larger cohorts of 103 patients with MRKH and 109 non-MRKH patients with genital malformations. No other patients were found with the cytosine deletion however one additional patient was identified regarding the missense mutation. Rare DNA sequence variations in the HOXA10 gene could contribute to the misdevelopment of female internal genitalia. PMID:23376215

Ekici, Arif B; Strissel, Pamela L; Oppelt, Patricia G; Renner, Stefan P; Brucker, Sara; Beckmann, Matthias W; Strick, Reiner

2013-04-15

217

Self-collected vaginal swabs for the quantitative real-time polymerase chain reaction assay of Atopobium vaginae and Gardnerella vaginalis and the diagnosis of bacterial vaginosis.  

Science.gov (United States)

The aim of this study was to assess the feasibility of using self-collected vaginal specimens for the quantitative real-time polymerase chain reaction (qPCR) assays of bacterial vaginosis (BV)-associated bacteria versus practitioner-collected swabs. A cross-sectional study included 190 pregnant women enrolled before 20 weeks' gestation from September 2008 to November 2009. Self- and practitioner-collected swabs were taken during the same prenatal visit for each woman, qPCR assays performed for each, and the results compared. The quantification of the human albumin gene was used as an internal control to ensure sampling quality and accurate comparisons. The level of agreement of the qPCR assays for each microorganism was calculated with the Spearman product moment correlation coefficient and the kappa statistic. In all, 370 vaginal samples (185 self- and 185 practitioner-collected swabs) had a narrow range of values for the number of albumin gene copies and a significant correlation coefficient (Spearman's rho?=?0.532; p?vaginae, 0.918 for Lactobacillus species, 0.940 for Gardnerella vaginalis; p?vaginae (?10(8) copies/mL; kappa value?=?0.973; p?vaginae. PMID:21789604

Menard, J-P; Fenollar, F; Raoult, D; Boubli, L; Bretelle, F

2012-04-01

218

Carcinoma of the vagina  

International Nuclear Information System (INIS)

Twenty-two patients with Stage I through IV primary vaginal squamous cell carcinomas treated for cure with radiation therapy are reviewed, with particular emphasis on the relationship of dose to complications and local control. All but 2 patients received 4000 to 6000 rad whole pelvis irradiation plus at least one radium application. Local control was 91%, with an absolute 2-year disease-free survival of 82%. The degree of anaplasia was found to influence prognosis, with all local and distant failures resulting from high-grade lesions. The complication rate was modest, with no fistulae or serious bowel complications. An analysis of total dose (external plus radium) with respect to local failure and complications showed that no major complications occurred at a combined dose below 9000 rad. An analysis of the individual contributions of external irradiation and radium implants showed that all but one very minor complication occurred at a radium dose of 4000 rad or higher. From these data, overall treatment planning and total dose recommendations are made

1978-11-01

219

Carcinoma of the vagina  

International Nuclear Information System (INIS)

There are two major difficulties in the management of vaginal carcinoma. First, irradiation alone has not provided adequate results in stage III and stage IV disease. Pelvic failures and distant metastases occur in half of the patients with advanced disease. The second problem is that the results of therapy for patients with nonepithelial tumors (sarcomas, melanomas) are poor

1987-01-01

220

Il Linguaggio della Vagina  

Directory of Open Access Journals (Sweden)

Full Text Available La cultura delle masse è oggi una cultura prevalentemente visuale. Tra i segni visuali da tempo in crescita è quello, caratteristico, della depilazione pubica femminile. Originata all'interno della cultura porno come segno di passività, questa pratica si è incontrata con i simboli della pulizia, dell'igiene, del rispetto, trasformando così il proprio significato in quello di autonomia e libertà. Così le donne possono depilarsi per scopi erotici minimizzando però la valenza sessuale del gesto tramite la tendenza alla super-igiene.

Marco Menicocci

2011-12-01

 
 
 
 
221

Normal tissue tolerance to external beam radiation therapy: The vagina; Dose de tolerance a l'irradiation des tissus sains: le vagin Normal  

Energy Technology Data Exchange (ETDEWEB)

The vagina is a virtual cavity involved in sexual reproduction field. Due to its anatomical location, it may be exposed in whole or in part to ionizing radiation in external radiotherapy and/or brachytherapy of the pelvic region. This review aims to describe the vaginal acute and late side effects due to radiation, probably inadequately reported in the literature. Medline and PubMed literature searches were performed using the keywords -vaginal - radiotherapy - toxicity. The acute and late functional changes after external beam radiation consist mainly of drought. Their incidences are poorly described in the literature and the delivered doses even less. Recommendations are non-existent as the normal tissue complication probability (NTCP). Brachytherapy delivers high and heterogeneous doses, making it difficult to estimate the dose. The concomitant administration of chemotherapy appears to be a factor increasing the risk of toxicity. Modern techniques of conformal radiotherapy with modulated intensity appear to have little impact on this body. Only a maximum dose on each third of the vagina appears to be currently proposed to avoid the risk of side effects. (authors)

Magne, N. [Unite de curietherapie, departement de radiotherapie, institut de cancerologie de la Loire, 42 - Saint-Priest-en-Jarez (France); Chargari, C. [Service d' oncologie radiotherapie, hopital d' instruction des armees du Val-de-Grace, 75 - Paris (France); Pointreau, Y. [Clinique d' oncologie radiotherapie, centre Henry-S.-Kaplan, hopital de Bretonneau, CHU de Tours, 37 - Tours (France); Haie-Meder, C. [Service de curietherapie, departement de radiotherapie, institut Gustave-Roussy, 94 - Villejuif (France)

2010-07-15

222

Histologia e morfometria das glândulas das junções infundíbulo-magno e útero-vagina de codorna doméstica Histology and morphometry of the infundibulum-magnum and uterus-vaginal junctions of spotted quails  

Directory of Open Access Journals (Sweden)

Full Text Available A análise comparativa das glândulas armazenadoras de espermatozóides das junções infundíbulo-magno e útero-vagina do oviduto da codorna Nothura maculosa foi realizada durante a fase reprodutiva. As aves foram eutanasiadas por inalação com éter etílico, após a pesagem. Após a laparotomia e o deslocamento cranial do esterno, foram coletadas amostras de dois centímetros da junção infundíbulo-magno e útero-vagina. Os fragmentos foram fixados em solução de Bouin por 24 horas e, posteriormente, banhos sucessivos de álcool 70% foram aplicados sobre as amostras. Em seguida, as amostras foram desidratadas em uma série de concentração crescente de alcoóis (80, 90, 95 e 3x100%, diafanizadas em xilol e incluídas em parafina. Cortes histológicos de sete micrômetros de espessura foram obtidos e corados pela técnica da Hematoxilina-eosina (HE, que foram analisados e fotomicrografados em um fotomicroscópio Olympus BX-50. Para a análise morfométrica, foram capturadas imagens das glândulas armazenadoras de espermatozóides da junção infundíbulo-magno e útero-vagina mediante o programa computacional "Image Pro Plus 4.1" da Cibernetics do Brasil, tornando-se possível a quantificação das mesmas. A mucosa da junção infundíbulo-magno apresentou pregas estreitas no infundíbulo e largas no magno, enquanto na junção útero-vagina mostrou-se amplamente pregueada na vagina e mais lisa na porção uterina. O número médio de glândulas armazenadoras de espermatozóides na junção infundíbulo-magno foi maior (11,7 glândulas (PThe comparative analysis of sperm-host glands of infundibulum-magnum and uterus-vagina junctions of Nothura maculosa quail oviduct was done during the reproductive phase. The birds were euthanized with ethyl ether after weight data were taken. After abdominal laparotomy and cranial displacement of the breastbone, two centimeters samples of infundibulum-magnum and uterus-vagina junctions were collected. The samples were fixed in Bouin's solution for twenty four hours and later, successive baths of alcohol 70% were applied on samples and soon afterwards dehydrated in a series of grow concentration alcohols (80, 90, 95 and 3x100%, diaphanized in xylol and included on paraffin. Histological sections with seven micrometers thickness were obtained and stained on Haematoxylin-Eosin (HE technique, then they were analyzed and photomicrographed in a photomicroscope Olympus BX-50. For the morphometry analysis, infundibulum-magnum junctions and uterus-vagina sperm host gland images were captured through a computacional program Image Pro Plus 4.1", Cibernetics Brazil, making it possible to quantify them. The mucosa of the infundibulum-magnum junction presented very narrow folds in the infundibulum and too large in the magnum, while in the uterus-vagina junction was observed widely folds mucous in the vagina and smoother in the uterine portion. The average of sperm host gland in the infundibulum-magnum junction was higher (11.7 glands (P<0.01 compared to the uterus-vagina junction (7.5 glands. It is supposed that the abundance number of sperm host glands in infundibulum-magnum junction allows faster access of the oocyte, after the ovulation of the host spermatozoid ensuring the fertilization.

Carime Moraes

2009-04-01

223

Effects of depomedroxyprogesterone acetate on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats (Rattus norvegicus)  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese O objetivo do presente estudo foi determinar os efeitos do acetato de depomedroxyprogesterona (ADMP) no desenvolvimento e manutenção de Candida albicans na vagina de ratas Wistar ooferectomizadas. Os animais foram divididos em grupos controle negativos (GCN), que receberam injeções de salina estéril [...] ; grupos controle positivos (GCP), que receberam injeções de valerato de estradiol; e grupos progesterona (GP), nos quais foram feitas injeções de Depo-Provera®. Após uma semana da aplicação hormonal, foi induzida a infecção vaginal por C. albicans em todos os grupos, detectada por cultura para leveduras vaginais e esfregaço de Papanicolaou. Foram feitas ainda imagens por microscopia eletrônica de varredura e transmissão para confirmar a infecção pela levedura no GP. Foram observados diferentes níveis de progesterona em GP, entre os valores basais e após a indução hormonal (P Abstract in english The objective of this study was to determine the effect of medroxyprogesterone acetate (DMPA) on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats. The animals were divided into negative control groups (NCG), which received injections of sterile saline; [...] positive control groups (PCG), which were given injections of estradiol valerate; and progesterone groups (PG), which were given injections of Depo-Provera®. After one week of hormonal induction, vaginal infection by C. albicans was induced in all the groups and detected by vaginal yeast culture and Papanicolaou smear. In addition, scanning and transmission electron microscopy images were obtained to confirm the vaginal infection by yeast in PG. A difference in progesterone levels in PG was observed between the basal level and after hormonal induction (P

Storti-Filho, Agenor; Damke, Edilson; Carrara, Márcia Aparecida; Batista, Marcia Regina; Donatti, Lucélia; Boer, Cinthia Gandolfi; Svizdinski, Terezinha Inez Estivalet; Consolaro, Márcia Edilaine Lopes.

224

Effects of depomedroxyprogesterone acetate on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats (Rattus norvegicus  

Directory of Open Access Journals (Sweden)

Full Text Available The objective of this study was to determine the effect of medroxyprogesterone acetate (DMPA on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats. The animals were divided into negative control groups (NCG, which received injections of sterile saline; positive control groups (PCG, which were given injections of estradiol valerate; and progesterone groups (PG, which were given injections of Depo-Provera®. After one week of hormonal induction, vaginal infection by C. albicans was induced in all the groups and detected by vaginal yeast culture and Papanicolaou smear. In addition, scanning and transmission electron microscopy images were obtained to confirm the vaginal infection by yeast in PG. A difference in progesterone levels in PG was observed between the basal level and after hormonal induction (PO objetivo do presente estudo foi determinar os efeitos do acetato de depomedroxyprogesterona (ADMP no desenvolvimento e manutenção de Candida albicans na vagina de ratas Wistar ooferectomizadas. Os animais foram divididos em grupos controle negativos (GCN, que receberam injeções de salina estéril; grupos controle positivos (GCP, que receberam injeções de valerato de estradiol; e grupos progesterona (GP, nos quais foram feitas injeções de Depo-Provera®. Após uma semana da aplicação hormonal, foi induzida a infecção vaginal por C. albicans em todos os grupos, detectada por cultura para leveduras vaginais e esfregaço de Papanicolaou. Foram feitas ainda imagens por microscopia eletrônica de varredura e transmissão para confirmar a infecção pela levedura no GP. Foram observados diferentes níveis de progesterona em GP, entre os valores basais e após a indução hormonal (P<0,0001. Neste grupo, 100,0% das ratas contraíram a infecção vaginal na primeira semana, mas não a mantiveram até a terceira semana. A forma farmacêutica de ADMP foi efetiva em induzir as fases de metaestro e diestro do ciclo estral das ratas, da mesma forma que usando progesterona pura. Em contraste com o que ocorre no tratamento com estrógeno, a progesterona não pôde manter a infecção vaginal experimental por C. albicans por um período significativo de tempo.

Agenor Storti-Filho

2011-03-01

225

Detection of the Human 70-kD and 60-kD Heat Shock Proteins in the Vagina: Relation to Microbial Flora, Vaginal pH, and Method of Contraception  

Directory of Open Access Journals (Sweden)

Full Text Available The expression of the 60-kD and 70-kD heat shock proteins (hsp60 and hsp70 in the vaginas of 43 asymptomatic women of reproductive age with or without a history of recurrent vulvovaginitis (RVV were compared. Vaginal wash samples were obtained and assayed by enzyme-linked immunosorbent assay (ELISA for human hsp60 and hsp70. Heat shock protein 70 was not detected in any of the 19 women with no history of RVV, and hsp60 was present in only one woman in this group. In contrast, in the RVV group, 11 (45.8% were hsp60-positive and eight (33.3% were hsp70-positive. The presence of either heat shock protein in the vagina was associated with an elevated vaginal pH (>4.5. Bacterial vaginosis or Candida was identified in some of the asymptomatic subjects; their occurrence was significantly higher in women with vaginal hsp70 than in women with no heat shock proteins. Oral contraceptives were used by 35.7% of subjects who were negative for vaginal heat shock proteins, as opposed to only 12.5% of women who were positive for hsp70 and 8.3% who were positive for hsp60. Expression of heat shock proteins in the vagina may indicate an altered vaginal environment and a susceptibility to vulvovaginal symptoms. Infect. Dis. Obstet. Gynecol. 7:23–25, 1999.

S. S. Witkin

1999-01-01

226

HUBUNGAN AKTIVITAS SEKSUAL PADA USIA DINI, PROMISKUITAS DAN BILAS VAGINA DENGAN KEJADIAN KANKER LEHER RAHIM PADA PASIEN ONKOLOGY DI RSUD Dr.MOEWARDI SURAKARTA  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Cervical cancer ranks the top cause of cancer deaths in developing countries. At Dr. Moewardi Hospital Surakarta cervical cancer was found in most cancers. Risk factors associated with health and cleanliness of the female reproductive tract can increase the incidence of cervical cancer. Purpose this study aims to determine factors associated with female reproductive health tract and the occurrence of cervical cancer. Method: The study was a quantitative analytical research used cross sectional design. Data used primary data from interviews and secondary data from medical records. Bivariate analysis using chi square test used to prove the hypothesis. Results: Statistical analysis by chi square test for sex at an early age got p value=0,382 and the prevalence ratio= 1,375, for promiscuity with incidence cervical cancer got p value=0,481 and prevalence ratio=1,314, for vaginal douching with incidence cervical cancer got p value=0,121 and prevalence ratio=0,571. Conclusion: There was no significant correlation between sex on early age with incidence of cervical cancer, there was no significant correlation between promiscuity with incidence of cervical cancer, there was no significant correlation between vaginal douching with incidence of cervical cancer at Dr. Moewardi Hospital Surakarta on Mey until Juny 2010. Key words: sex at an early age, promiscuity, rinse the vagina, cervix cancer

. Ridhaningsih

2013-04-01

227

Citologia Hormonal do Trato Urinário Baixo e da Vagina de Mulheres na Pós-menopausa, antes e durante Estrogenioterapia Oral e Transdérmica Urinary and Vaginal Cytology of Postmenopausal Women with Oral and Transdermal Estrogen Replacement  

Directory of Open Access Journals (Sweden)

Full Text Available Objetivo: avaliar a ação dos estrogênios por via oral ou transdérmica nas células do trato urinário baixo e da vagina, em mulheres menopausadas. Métodos: foram incluídas 25 mulheres na pós-menopausa, nas quais se estudaram os efeitos citológicos da terapia de reposição hormonal estrogênica, por via oral e por via transdérmica, sobre as células da vagina e do sedimento urinário. As pacientes foram distribuídas aleatoriamente em 2 grupos: Grupo I, constituído por 14 mulheres que receberam 0,625 mg de estrogênio conjugado eqüino associado a 5 mg de acetato de medroxiprogesterona, por via oral, diariamente sem intervalo por três meses, e Grupo II, formado por 11 mulheres que fizeram uso de 17-beta-estradiol matricial na dose de 50 mig, por via transdérmica, semanalmente, associado a 5 mg de acetato de medroxiprogesterona diariamente por três meses. As amostras urinárias foram obtidas do jato inicial da primeira urina da manhã, após asseio dos genitais, em frascos estéreis fornecidos pelo laboratório. A urina foi centrifugada e o esfregaço realizado a partir do sedimento urinário. Os esfregaços da vagina e do sedimento urinário foram imediatamente fixados em álcool absoluto e corados pelo método de Shorr. Resultados: observou-se que nas pacientes que utilizaram a via oral, houve maturação das células da vagina (o índice se elevou de 45,4 a 65,5 com dois meses de tratamento, permanecendo praticamente constante (62,0 a seguir. Quanto às células urinárias, não houve variação do valor de maturação (56,4 antes da medicação e 60,4 no final do período. Ao examinarmos tanto as células da urina quanto da vagina de pacientes que utilizaram a via transdérmica, notou-se que houve resposta satisfatória. Conclusão: com estes resultados podemos sugerir que os estrogênios, quando administrados por via transdérmica, estão associados à resposta satisfatória quanto ao trofismo tanto na vagina quanto na uretra. No entanto, quando se utiliza a via oral, nem sempre este resultado pode ser observado.Objective: to study the effects of oral or transdermal estrogen replacement on the lower urinary tract and vagina in postmenopausal women. Methods: we studied 25 postmenopausal women evaluating the oral or transdermic estrogen replacement effects on the vaginal cells and urinary sediment during 3 months. The patients were randomly distributed into 2 groups: Group I, n = 14, treated orally with 0.625 mg equine conjugated estrogen plus 5 mg medroxyprogesterone acetate, daily for 3 months; Group II, n = 11, treated transdermally with 50 mug 17-ß-estradiol, once a week, plus 5 mg medroxyprogesterone. Daily, for 3 months, urinary samples were collected from the first miction in the morning after urogenital antisepsis into sterile tubes. The sample was centrifuged and the sediment was smeared. Vaginal and urinary smears were then fixed in absoluted alcohol and stained by the method of Shorr. Results: the patients who used the oral route presented maturation of the vaginal cells (from 45.4 to 65.5% after 2 months of treatment, maintaing 62% afterwards but this did not occur with urinary cells (56.4 before treatment versus 60.4% at the end of the period. The transdermal route promoted maturation of vaginal and urinary cells. Conclusion: we have concluded that transdermal estrogens have satisfactory effects both on vaginal and urethral sites. However, with the oral route we did not find the expected results in the urinary tract in all cases.

Áurea Belas Lustosa

2002-10-01

228

Citologia Hormonal do Trato Urinário Baixo e da Vagina de Mulheres na Pós-menopausa, antes e durante Estrogenioterapia Oral e Transdérmica / Urinary and Vaginal Cytology of Postmenopausal Women with Oral and Transdermal Estrogen Replacement  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Objetivo: avaliar a ação dos estrogênios por via oral ou transdérmica nas células do trato urinário baixo e da vagina, em mulheres menopausadas. Métodos: foram incluídas 25 mulheres na pós-menopausa, nas quais se estudaram os efeitos citológicos da terapia de reposição hormonal estrogênica, por via [...] oral e por via transdérmica, sobre as células da vagina e do sedimento urinário. As pacientes foram distribuídas aleatoriamente em 2 grupos: Grupo I, constituído por 14 mulheres que receberam 0,625 mg de estrogênio conjugado eqüino associado a 5 mg de acetato de medroxiprogesterona, por via oral, diariamente sem intervalo por três meses, e Grupo II, formado por 11 mulheres que fizeram uso de 17-beta-estradiol matricial na dose de 50 mig, por via transdérmica, semanalmente, associado a 5 mg de acetato de medroxiprogesterona diariamente por três meses. As amostras urinárias foram obtidas do jato inicial da primeira urina da manhã, após asseio dos genitais, em frascos estéreis fornecidos pelo laboratório. A urina foi centrifugada e o esfregaço realizado a partir do sedimento urinário. Os esfregaços da vagina e do sedimento urinário foram imediatamente fixados em álcool absoluto e corados pelo método de Shorr. Resultados: observou-se que nas pacientes que utilizaram a via oral, houve maturação das células da vagina (o índice se elevou de 45,4 a 65,5 com dois meses de tratamento, permanecendo praticamente constante (62,0) a seguir. Quanto às células urinárias, não houve variação do valor de maturação (56,4 antes da medicação e 60,4 no final do período). Ao examinarmos tanto as células da urina quanto da vagina de pacientes que utilizaram a via transdérmica, notou-se que houve resposta satisfatória. Conclusão: com estes resultados podemos sugerir que os estrogênios, quando administrados por via transdérmica, estão associados à resposta satisfatória quanto ao trofismo tanto na vagina quanto na uretra. No entanto, quando se utiliza a via oral, nem sempre este resultado pode ser observado. Abstract in english Objective: to study the effects of oral or transdermal estrogen replacement on the lower urinary tract and vagina in postmenopausal women. Methods: we studied 25 postmenopausal women evaluating the oral or transdermic estrogen replacement effects on the vaginal cells and urinary sediment during 3 mo [...] nths. The patients were randomly distributed into 2 groups: Group I, n = 14, treated orally with 0.625 mg equine conjugated estrogen plus 5 mg medroxyprogesterone acetate, daily for 3 months; Group II, n = 11, treated transdermally with 50 mug 17-ß-estradiol, once a week, plus 5 mg medroxyprogesterone. Daily, for 3 months, urinary samples were collected from the first miction in the morning after urogenital antisepsis into sterile tubes. The sample was centrifuged and the sediment was smeared. Vaginal and urinary smears were then fixed in absoluted alcohol and stained by the method of Shorr. Results: the patients who used the oral route presented maturation of the vaginal cells (from 45.4 to 65.5% after 2 months of treatment, maintaing 62% afterwards) but this did not occur with urinary cells (56.4 before treatment versus 60.4% at the end of the period). The transdermal route promoted maturation of vaginal and urinary cells. Conclusion: we have concluded that transdermal estrogens have satisfactory effects both on vaginal and urethral sites. However, with the oral route we did not find the expected results in the urinary tract in all cases.

Áurea Belas, Lustosa; Manoel João Batista Castello, Girão; Marair Gracio Ferreira, Sartori; Edmund Chada, Baracat; Geraldo Rodrigues de, Lima.

229

Detection of the human 70-kD and 60-kD heat shock proteins in the vagina: relation to microbial flora, vaginal pH, and method of contraception.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The expression of the 60-kD and 70-kD heat shock proteins (hsp60 and hsp70) in the vaginas of 43 asymptomatic women of reproductive age with or without a history of recurrent vulvovaginitis (RVV) were compared. Vaginal wash samples were obtained and assayed by enzyme-linked immunosorbent assay (ELISA) for human hsp60 and hsp70. Heat shock protein 70 was not detected in any of the 19 women with no history of RVV, and hsp60 was present in only one woman in this group. In contrast, in the RVV gr...

Giraldo, P.; Neuer, A.; Ribeiro-filho, A.; Linhares, I.; Witkin, S. S.

1999-01-01

230

Recurrent leiomyoma of the vagina.  

Science.gov (United States)

A rare case of huge vaginal leiomyoma recurrence is reported. Vaginal leiomyoma is a rare entity and recurrence after its removal is extremely rare. However, if recurrence occurs with intact ovarian function ovariectomy should also be done. PMID:1350544

Dhaliwal, L K; Das, I; Gopalan, S

1992-04-01

231

[Microbial ecology of the vagina].  

Science.gov (United States)

In this review recent information on relationships between the vaginal environment and microflora, including new taxonomic groups of microorganisms, is updated. The role of normal microflora in formation of vaginal colonization resistance and possible participation of some representatives of normal microflora, mainly nonsporulating anaerobic organisms, in the development of perinatal, neonatal and gynecological infectious complications are considered. PMID:12506639

Kafarskaia, L I; Korshunova, O V; Efimov, B A; Volodin, N N; Korshunov, V M

2002-01-01

232

Estrogen and the irradiated vagina  

International Nuclear Information System (INIS)

The vaginal response of patients to estrogen therapy following radiotherapy for cervical carcinoma is discussed. The authors take exception to the statement of Abitbol and Davenport that irradiation destroys the possibility of a vaginal response to estrogen stimulation

1975-01-01

233

Prevalência de cândida na flora vaginal de mulheres atendidas num serviço de planejamento familiar Prevalence of candida in the vagina of women attended at a family planning service  

Directory of Open Access Journals (Sweden)

Full Text Available RESUMO Objetivo: avaliar a prevalência de Candida sp. e a distribuição de suas espécies na flora vaginal de mulheres numa clínica de planejamento familiar. Método: estudo transversal no qual se avaliaram prospectivamente 72 mulheres não-grávidas, com ou sem queixas específicas, sendo coletadas amostras de secreção vaginal para cultura de leveduras, efetuada a medição do pH vaginal e anotados dados de achados do exame ginecológico. Resultados: leveduras pertencentes ao gênero Candida foram encontradas em 18 casos (25%. A C. albicans foi a espécie mais prevalente (77,8% e conseqüentemente 22,2% foram não-albicans. Entre as não-albicans a espécie mais prevalente foi a C. glabrata (16,7% seguida pela C. parapsilosis (5,6%. Prurido e ardor foram os únicos sintomas relacionados significativamente com a presença de cândida. Foi observado que a C. glabrata, ao contrário da C. albicans, não causa corrimento clinicamente verificável ao exame ginecológico. Não foram verificadas associações de alguns fatores predisponentes (idade, escolaridade e uso de contraceptivos com a presença ou não de cândida. Conclusões: nossos resultados sugerem: a uma alta prevalência de Candida sp. entre as mulheres (25%; b que as espécies não-albicans desempenham um papel importante no meio vaginal; c que prurido e ardor são os sintomas mais comuns na presença de cândida e d que a C. glabrata não costuma causar corrimento vaginal ao exame ginecológico. Finalmente, é importante observar que nossos resultados são consistentes com o que a literatura internacional tem mostrado nos últimos anos.SUMMARY Purpose: to estimate the prevalence of Candida sp. and the distribution of its species in the vagina of women attended at a family planning Service. Methods: a cross-sectional study evaluating prospectively 72 nonpregnant women, with or without specific complaints. Samples were checked for the presence of yeast and vaginal pH. Data obtained by gynecologic examination were also recorded. Results: yeast belonging to the genus Candida was isolated from 18 (25% patients. The most prevalent species was C. albicans (77,8% and therefore, 22.2% were non-albicans species. The most prevalent among the non-albicans species was C. glabrata (16.7% followed by C. parapsilosis (5.6%. The symptoms most directly associated with Candida were itching and burning. Different from the symptoms directly associated with C. albicans infection, we observed that C. glabrata does not cause vaginal discharge. There was no positive association between predisponent factors such as age, education and contraceptive method used and the presence or absence of Candida. Conclusions: our results suggest: (i that there is a high prevalence of Candida species among women; (ii that non-albicans species play an important role in the vaginal medium; (iii that itching and burning are the most common symptoms in women with Candida, and (iv C. glabrata usually does not cause vaginal discharge. Finally, it is important to emphasize that our results are consistent with the present worldwide findings.

Antônio Aleixo Neto

1999-01-01

234

MRI of the uterus, uterine cervix, and vagina: diagnostic performance of dynamic contrast-enhanced fast multiplanar gradient-echo imaging in comparison with fast spin-echo T2-weighted pulse imaging  

International Nuclear Information System (INIS)

The aim of this study was to compare the diagnostic performance of contrast-enhanced fast multiplanar gradient-echo (GRE) and T2-weighted fast spin-echo (FSE) image sets in the assessment of uterus, cervix, and vagina. Fast (up to 20 contiguous sections in 23 s) multiplanar GRE and FSE images of 45 patients referred for imaging of the female pelvis were evaluated retrospectively with regard to overall image quality and the ability to detect normal anatomic structures, as well as lesion conspicuity. Results were compared with histologic findings (n = 29) or clinical follow-up. Furthermore, a quantitative assessment of contrast-to-noise ratios among normal uterine and cervical structures as well as uterine lesions was performed for both sequences. On GRE images, uterine and cervical differentiation was best seen on the image sets acquired 15 and 60 s following contrast enhancement and results were significantly better compared with delayed images (p 2 test, the difference in diagnostic performance between FSE and GRE revealed no significant difference, whereas the combination of both techniques performed better than FSE imaging alone (p < 0.05). The presented data suggest that dynamic contrast-enhanced GRE imaging should be part of an MR examination of the female pelvis. Combined GRE and FSE imaging provide an excellent sensitivity in the assessment of uterine and vaginal pathologies. (orig.) (orig.)

1998-10-01

235

Primary invasive squamous carcinoma of the vagina  

International Nuclear Information System (INIS)

Forty-three cases of primary vaginal squamous cell cancer were treated at the University of Wisconsin Hospital between 1956 and 1971. These cases comprised of 1.2% of patients admitted to the University Hospital with female genital tract cancer. Evidence is presented to support a modification of the currently accepted FIGO staging system for vaginal carcinoma (Stage II disease). Radiation therapy using both external beam and brachyradium equivalents or interstitial implantation of suitable isotopes was an effective method for the treatment of patients having early and locally advanced invasive vaginal cancer. The 5-year absolute survival rate for the entire series was 37.2%. Absolute survival rate by modified FIGO clinical staging was 66% for Stages I and IIA, 31% for Stage IIB, 25% for Stage III, and 0% for Stage IV

1979-01-01

236

Congenital malformations of uterus and vagina  

International Nuclear Information System (INIS)

The radiographic findings according to the classification of Buttram and Gibbons are described for HSG, ultrasound and MRI. The advantages and limitations of each method are discussed, and finally an algorithm for imaging is recommended. (orig.)

1994-07-01

237

Caracterización de la microbiota levaduriforme residente en la vagina de perras en diferentes fases del ciclo estral Characterization of vaginal microbiotic yeasts of bitches in distinct stages of the oestrous cycle  

Directory of Open Access Journals (Sweden)

Full Text Available Hongos levaduriformes son aislados frecuentemente de los animales domésticos y silvestres, siendo algunos comensales del tegumento y mucosas. Las levaduras son frecuentes en la mucosa vaginal de las mujeres, pero en perras son escasos los estudios referentes a la microbiota fúngica vaginal, sin conocerse su relación con el ciclo reproductivo. En este estudio se buscó aislar e identificar levaduras de la microbiota vaginal de perras, y establecer si hay alteración de la microbiota levaduriforme en las fases del ciclo reproductivo. Se analizaron 75 muestras de la vagina de 75 perras de los caniles particulares (Grupo I y 224 muestras de 14 perras experimentales (Grupo II. El ciclo estral fue determinado por citología vaginal y se registraron observaciones clínicas como sangrado, edema y pliegues de vulva. Las muestras fueron sometidas a examen directo y cultivos en Agar-Sabouraud dextrosa con cloranfenicol, a 37 ºC por 10 días. Las levaduras fueron clasificadas por macro y micromorfología, pruebas bioquímicas, tubo germinativo y microcultivo. De las 75 muestras del grupo I, el aislamiento fue 33,3% (n = 25; las muestras fueron obtenidas en las fases de proestro 56,3%, estro 16,7%, diestro 66,7% y anestro 20,5%, respectivamente. De las 224 muestras del grupo II se aislaron levaduras en 147 (65,6%: en proestro 61,9%, estro 71,9%, diestro 82,7% y anestro 57,1%, respectivamente. Las levaduras fueron identificadas como Candida spp, Malassezia pachydermatis y Rhodoturola spp. Los resultados sugieren que estas levaduras forman parte de la microbiota vaginal de perras sanas y sus frecuencias se alteran en las fases del ciclo reproductivo.Yeasts are commensal organisms frequently isolated from the skin and mucous membranes of domestic and wild mammals. Although yeasts are frequently isolated from women’s vaginal mucus, similar studies in canine are rare, therefore their behaviour during the canine oestrous cycle is unknown. The purpose of this study was to isolate yeasts from the vaginal microbiota of bitches and to evaluate their behaviour in different stages of the oestrous cycle. We examined 75 samples of mucus from the vaginal cavity of 75 domestic bitches and 224 samples from 14 experimental bitches. The stages of the oestrous cycle were characterized through vaginal cytology and clinical observation of bleeding, vulvar oedema and pucker. Samples were examined visually, and also cultured in Sabouraud dextrose agar with chloranphenicol, at 37 ºC for 10 days. The yeasts were classified according to their macro and micro morphology, biochemical tests, germination tube and micro culture. Yeasts were isolated from 25 (33.3% samples from domestic females. Among the samples collected during proestrous, oestrous, diestrous and anestrous, 56.3% 16.7% 66.7% and 20.5% were positive, respectively. Yeasts were isolated from 147 (65.6% samples from experimental bitches. Among the samples collected during proestrous, oestrous, diestrous and anestrous, positive samples represented 61.9%, 71.9%, 82.7%, and 57.1%, respectively. The identified species were Candida spp, M. pachydermatis and Rhodotorula spp, which are commonly present in the vaginal mucus microbiota of healthy bitches and their frequency changes with the different stages of the oestrous cycle.

M B Cleff

2007-01-01

238

Presencia de malla de prolene en vagina / The presence of a Prolene mesh in the vagina  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Describir un caso clínico de una paciente en la que tras la colocación de malla de Prolene® como refuerzo en la corrección de cistocele recidivado, presenta complicaciones. Método/resultado: Paciente mujer de 75 años de edad con antecedentes de corrección de cistocele con malla de prolene [...] presenta incontinencia de orina y erosión vaginal por la propia malla. Conclusiones: El uso de malla para la corrección de cistocele tiene la ventaja de aportar mayor soporte a la colporrafia y evitar la recidiva del cistocele, aunque puede presentar complicaciones como en nuestro caso clínico de migración de la malla, aparición de fístula, infección o intolerancia. Abstract in english Objective: To describe the clinical case of a patient presenting complications after the implantation of a Prolene mesh as reinforcement for the correction of a recurrent cystocele. Methods/results: Seventy-five-years-old female patient with history of previous cystocele repair with Prolene mesh pre [...] senting urinary incontinence and vaginal erosion of the mesh. Conclusions: The use of mesh for the repair of cystoceles has the advantage of providing greater support to the colporrhaphy and avoiding recurrences. Nevertheless, it may present complications as in our reported case with mesh migration, fistula, infection, or intolerance.

Anna, Bujons; Carlos, Errando; Manel, Prados; Carlos, Báez; Pedro, Arañó; Humberto, Villavicencio.

239

Radiotherapeutic management of carcinomas of the vagina and vulva  

International Nuclear Information System (INIS)

Purpose: To review important basic information regarding vaginal and vulvar carcinomas, including etiology, epidemiology, anatomy, pathology, spread patterns, presentation and work-up and staging. In addition, treatment concepts strategies, and radiotherapeutic techniques will be reviewed and discussed. Discussion: Vaginal carcinoma is rare, making up only 1-2% of gynecologic malignancies. However, the predominant role of radiotherapy (RT) is its management results in a significant number of patients referred to radiation oncology. Treatment and outcomes vary substantially according to stage. Important issues for consideration include the respective roles of external beam RT, brachytherapy, and surgery, intracavitary vs. interstitial brachytherapy, dose rate considerations, combined modality therapy, and management of non-squamous cell histologies. Vulvar carcinoma is similarly uncommon, comprising only 3-5% of gynecologic malignancies. Radiotherapy has a number of established roles in the management of this disease including adjuvant therapy, as part of combined modality treatment for advanced disease, salvage therapy, palliative treatment, and less often, as primary management. These issues will be discussed along with technical factors important in radiotherapeutic management. Finally, relevant literature will be reviewed with an emphasis of completed Gynecologic Oncology Group Trials

1997-01-01

240

Late effects of ionizing radiations on vulva, vagina and uterus  

International Nuclear Information System (INIS)

Reporting and scoring complications after radiotherapy of gynaecological cancers is difficult because of the variety of treatment techniques involved. Use of an international classification is necessary to compare results obtained in series of patients treated in different institutions. An international group of experts designed in the early nineties the so-called French-Italian glossary. This classification of late effects is now completed with the new LENT SOMA scales. This paper contains details of these late changes, including their pathophysiology, clinical syndromes, potential treatment, and prevention. (authors)

1997-12-01

 
 
 
 
241

Didelphic uterus with imperforate unilateral vagina and ipsilateral renal agenesis: Magnetic resonance. Utero didelfo con vagina unilateral imperforada y agenesia renal ipsilateral: resonancia magnetica  

Energy Technology Data Exchange (ETDEWEB)

We present two cases of didelphic uterus with the clinical appearance of a pelvic mass produced by the hematometra-hematocolpos retained by an imperforate unilateral hemivagina. In both cases, this anomaly was accompanied by ipsilateral renal agenesis. We basically review the diagnosis of this disorder, focusing on magnetic resonance as the technique of choice. (Author) 10 refs.

Rodrigo, R.M.; Saez, F.; Astigarraga, E.; Rodriguez, O. (Hospital de Cruces. Servicio de Radiodiagnostico. Baracaldo.Vizcaya (Spain))

1993-01-01

242

Radiotherapy for carcinoma of the vagina. Immunocytochemical and cytofluorometric analysis of prognostic factors  

Energy Technology Data Exchange (ETDEWEB)

Background and purpose: The aim of this study was to assess the potential prognostic factors in patients with primary invasive vaginal carcinoma (PIVC) treated with radical irradiation. Patients and methods: The analysis was performed on 77 patients with PIVC treated between 1985 and 2005 in the Maria Sklodowska-Curie Memorial Institute of Oncology, Cancer Center in Krakow. A total of 36 patients (46.8 %) survived 5 years with no evidence of disease (NED). The following groups of factors were assessed for potential prognostic value: population-based (age), clinical (Karnofsky Performance Score [KPS], hemoglobin level, primary location of the vaginal lesion, macroscopic type, length of the involved vaginal wall, FIGO stage), microscopic (microscopic type, grade, mitotic index, presence of atypical mitoses, lymphatic vessels invasion, lymphocytes/plasmocytes infiltration, focal necrosis, VAIN-3), immunohistochemical (protein p53 expression, MIB-1 index), cytofluorometric (ploidity, index DI, S-phase fraction, proliferation index SG2M) factors. Results: Significantly better 5-year NED was observed in patients: < 60 years, KPS {<=} 80, FIGO stage I and II, grade G1-2, MIB-1 index < 70, S-phase fraction < 10, and proliferation index < 25. Independent factors for better prognosis in the multivariate Cox analysis were age < 60 years, FIGO stage I or II, and MIB-1 index < 70. Conclusion: Independent prognostic factors in the radically irradiated PIVC patients were as follows: age, FIGO stage, MIB-1 index. (orig.)

Blecharz, P. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Gynecological Oncology; Reinfuss, M.; Jakubowicz, J. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Radiation Oncology; Rys, J. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Tumor Pathology Oncology; Skotnicki, P.; Wysocki, W. [Maria Sklodowska-Curie Memorial Institute, Krakow (Poland). Dept. of Oncological Surgery

2013-05-15

243

Minimal criteria for the identification of Gardnerella vaginalis isolated from the vagina.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Vaginal swabs were examined for the presence of Gardnerella vaginalis. Of 294 isolates with appropriate colonial and cellular morphology subjected to an identification procedure, 203 (69%) were identified as G vaginalis. The 91 isolates not identified as G vaginalis were differentiated by their inability to ferment starch, cause diffuse beta haemolysis on human blood agar or hydrolyse hippurate. Other tests, often used in the identification of G vaginalis, were found to be insufficiently spec...

Jolly, J. L.

1983-01-01

244

Functional significance of muscarinic receptor expression within the proximal and distal rat vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Information regarding the role of cholinergic nerves in mediating vaginal smooth muscle contraction is sparse, and in vitro studies of the effects of muscarinic agonists on vaginal smooth muscle are discrepant. The goal of this study was to determine the expression of muscarinic receptors in the vaginal wall of the rat. In addition, we sought to determine the effect of the muscarinic receptor agonist carbachol on contractility and inositol phosphate production of the proximal and distal rat v...

2009-01-01

245

Primary invasive cancer of the vagina: outcome and complications of therapy  

International Nuclear Information System (INIS)

The aim of the present study was to review the characteristics of cases of vaginal cancer, results of treatment and complications occurring at Westmead Hospital over the period 1979-96. International Federation of Gynaecology and Obstetrics (FIGO) staging and Eastern Cooperative Oncology Group (ECOG) status had been recorded prospectively, while other information was obtained retrospectively, including complications using the Franco-Italian Glossary. There were 37 eligible patients, 34 of whom were treated radically. Five-year survival for stage I was 90%, for stage 11 it was 50%, and for stage III it was 40%. There was only one stage-V patient. The majority of patients who relapsed did so locally (63%). Using the Franco-Italian Glossary 10.8% of patients had, at worst, G0 toxicity, 21.6% had G1 toxicity, 29.7% had G2 toxicity, 37.8% had G3 toxicity, and no patients had G4 toxicity. Seven patients (18.9%) had a laparotomy for a complication of therapy. Excluding the three palliative patients and controlling for disease stage, it was found that there was a trend to improved survival in patients who had brachytherapy and those who suffered worse complications. While results for treatment of early stage vaginal cancer appear good, new techniques, particularly those that improve local control, are required for higher stage disease. Copyright (1999) Blackwell Science Pty Ltd

1999-11-01

246

Didelphic uterus with imperforate unilateral vagina and ipsilateral renal agenesis: Magnetic resonance  

International Nuclear Information System (INIS)

We present two cases of didelphic uterus with the clinical appearance of a pelvic mass produced by the hematometra-hematocolpos retained by an imperforate unilateral hemivagina. In both cases, this anomaly was accompanied by ipsilateral renal agenesis. We basically review the diagnosis of this disorder, focusing on magnetic resonance as the technique of choice. (Author) 10 refs

1993-01-01

247

Laparoscopic management of fallopian tube prolapse masquerading as adenocarcinoma of the vagina in a hysterectomized woman  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Fallopian tube prolapse as a complication of abdominal hysterectomy is a rare occurrence. A case with fallopian tube prolapse was managed by a combined vaginal and laparoscopic approach and description of the operative technique is presented. Case presentation A 39-year-old woman with vaginal prolapse of the fallopian tube after total abdominal hysterectomy presented with an incorrect diagnosis of adenocarcinoma of the vaginal apex. The prola...

Kucuk Mustafa

2002-01-01

248

The influence of radium therapie on the yeast contamination of the vagina  

International Nuclear Information System (INIS)

Before the beginning of radium therapy a vaginal yeast contamination of 9,7% was found of 113 patients with various genital carcinomas. However, the incidence of vaginal yeast contamination increased suddenly to 30,9% under the contac irradiation therapy with radium. The radiation effect of radium is not sufficient for a 'selfsterilisation' of the radium-carrier in the case of yeast contamination. Therefore, a chemic desinfection of the radium-carriers is principly necessary. The significance is discussed and the recommendation is made that routine mycological supervision be carried out on all patients with gynaecological carcinomas and appropriate antimycotic therapy initiated where necessary. (orig.)

1979-01-01

249

Primary Malignant Reticuloendothelial Disease Involving the Vagina, Cervix, and Corpus Uteri.  

Science.gov (United States)

Lymphoma and leukemic infiltrates presenting in the female reproductive tract are very rare. This study describes the clinical and pathologic findings in 15 patients: 13 with unrecognized lymphomas and 2 with an extramedullary neoplasm of poorly different...

I. Chorlton R. F. Karnei F. M. King H. J. Norris

1974-01-01

250

Adenocarcinoma of vagina: combined surgery and radiation with preservation of genital function  

International Nuclear Information System (INIS)

A report is given of a patient treated at Memorial Hospital, New York City, by external and fractionated intravaginal radiation given after a surgical procedure that consisted of local excision of tumor, pretreatment laparotomy, and lateral ovarian transposition. The treatment plan was based on the observations that there was no evidence of local or distant spread and that the ovaries could be moved to positions where radiation exposure would not terminate their activity. The patient has survived over six years and is without evidence of recurrence

1981-01-01

251

Air in vagina: significance in the staging of uterine cervical carcinoma  

International Nuclear Information System (INIS)

To evaluate the significance of vaginal air seen on CT scan in preoperative staging of uterine cervical carcinoma. A comparison was made between CT findings of vaginal fir and true vaginal involvement status in 85 patients with uterine cervical carcinoma. CT findings were analyzed in terms of the presence or absence of vaginal air, number of CT slices in which vaginal air was seen, shape of vaginal air, and relation of vaginal air to cervical mass. Vaginal air was present in 35 patients and was absent in 50. Although the mere presence of vaginal air or multiplicity of CT slices showing vaginal air did not signify the presence of vaginal involvement, vaginal air with irregular margin or vaginal air adjacent to uterine cervical mass was suggestive of vaginal involvement. These observation of vaginal air in interpreting CT may be helpful in the preoperative staging of uterine cervical carcinoma

1994-01-01

252

High-dose rate brachytherapy (HDRB) for primary or recurrent cancer in the vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Purpose The purpose of this study was to evaluate the efficacy of HDR brachytherapy for primary or recurrent vaginal cancer. Methods Between the years 2000 to 2006, 18 patients with primary or recurrent vaginal cancer were treated with brachytherapy (HDRB). Six patients had primary vaginal cancer (stage II to IVA) while 12 were treated for isolated vaginal recurrence (primary cervix = 4, vulva = 1 and endometrium = 7). Five patients had previous pelvic ...

Beriwal Sushil; Heron Dwight E; Mogus Robert; Edwards Robert P; Kelley Joseph L; Sukumvanich Paniti

2008-01-01

253

Radiotherapy of primary carcinoma of the vagina: management and results of different therapy schemes  

International Nuclear Information System (INIS)

Three hundred and sixty-two cases of primary vaginal carcinoma were treated at the Irradiation Department of the University Clinic for Obstetrics and Gynecology, Vienna, from 1950 to 1977. As the method of choice an individually dosed, fractioned, and protracted radium-telecobalt therapy was employed. Comparing the last period analyzed (1971-1977) with another period 20 years earlier (1951-1956), a marked increase of advanced stages and older patients can be observed. These changes are reflected in the 5-year remission rate: in the total population it was 39.8%, as compared to 32% for the period from 1971 to 1977. For a group of 99 patients, who were treated between 1971 and 1977, the therapeutic effect of different therapy schemes is reported. The benefit of teletherapy is remarkable for advanced states, whereas for stages I and II an intrauterine application may be of importance. The complication rate amounted to 8% recto- or vesicovaginal fistulas and 41% and 43% cystitis and proctitis. The central importance of gynecological screening, especially for older women, is emphasized

254

Importance of brachytherapy technique in the management of primary carcinoma of the vagina  

International Nuclear Information System (INIS)

Primary vaginal carcinoma is a rare malignancy. There is little information regarding the optimal treatment. Management has primarily been with external-beam radiation therapy and brachytherapy. This paper examines the importance of brachytherapy and the significance of its techniques in the treatment of this disease. Brachytherapy plays an important part in the management of primary vaginal carcinoma. External-beam radiation therapy alone is not an adequate treatment for this disease. For stages II and III disease, there is a trend toward improved disease-free survival with the use of a temporary interstitial implant compared to an intracavitary application

1991-12-01

255

Radiotherapy for carcinoma of the vagina. Immunocytochemical and cytofluorometric analysis of prognostic factors  

International Nuclear Information System (INIS)

Background and purpose: The aim of this study was to assess the potential prognostic factors in patients with primary invasive vaginal carcinoma (PIVC) treated with radical irradiation. Patients and methods: The analysis was performed on 77 patients with PIVC treated between 1985 and 2005 in the Maria Sklodowska-Curie Memorial Institute of Oncology, Cancer Center in Krakow. A total of 36 patients (46.8 %) survived 5 years with no evidence of disease (NED). The following groups of factors were assessed for potential prognostic value: population-based (age), clinical (Karnofsky Performance Score [KPS], hemoglobin level, primary location of the vaginal lesion, macroscopic type, length of the involved vaginal wall, FIGO stage), microscopic (microscopic type, grade, mitotic index, presence of atypical mitoses, lymphatic vessels invasion, lymphocytes/plasmocytes infiltration, focal necrosis, VAIN-3), immunohistochemical (protein p53 expression, MIB-1 index), cytofluorometric (ploidity, index DI, S-phase fraction, proliferation index SG2M) factors. Results: Significantly better 5-year NED was observed in patients: < 60 years, KPS ? 80, FIGO stage I and II, grade G1-2, MIB-1 index < 70, S-phase fraction < 10, and proliferation index < 25. Independent factors for better prognosis in the multivariate Cox analysis were age < 60 years, FIGO stage I or II, and MIB-1 index < 70. Conclusion: Independent prognostic factors in the radically irradiated PIVC patients were as follows: age, FIGO stage, MIB-1 index. (orig.)

2013-05-01

256

Iterstitial gamma-therapy of recurrences and metastases of uterine and rectal cancer to the vagina  

International Nuclear Information System (INIS)

A technique of interstitial radiation therapy for locally disseminated vaginal recurrences and metastases that occOr after the use of various therapeutic methods for uterine and rectal cancer is devised. Indications and coUnterindications to interstitial radiation therapy with 60Co as an independent method or the main therapeutic component in combined or multimodality treatment, were determined. Methods of the topometric and dosimetric planning of treat-- ment, methods of needle administration and fixation by the system of manual afterloading were developed. Interstitial radiation therapy was given to 22 patients with a complete tumor regression in 17 of them. Interstitial radiation therapy is recommended as a method of choice for the therapy of vaginal recurrences and metastases

1984-01-01

257

Isolated epithelioid trophoblastic tumor of the vagina: a case report and review of the literature  

Directory of Open Access Journals (Sweden)

Full Text Available Jing Zhao,1 Yang Xiang,1 Dachun Zhao,2 Tong Ren,1 Fengzhi Feng,1 Xirun Wan1 1Department of Obstetrics and Gynecology, 2Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Abstract: An epithelioid trophoblastic tumor (ETT is a rare trophoblastic tumor originating from chorionic-type intermediate trophoblasts. Vaginal involvement in ETT in the form of isolated lesions has not been previously reported. A 43-year-old woman presented with vaginal wall cysts and was diagnosed with ETT by pathological examination after cystectomy. No clinical evidence of uterine involvement was found at diagnosis or during follow-up. The patient was treated with chemotherapy and surgery after the first recurrence and underwent follow-up for 8 months. The serum human chorionic gonadotropin titer remained at undetectable levels. Keywords: ETT, isolated lesions, vaginal involvement

Zhao J

2013-10-01

258

Uterus didelphys with an obstructed unilateral vagina and ipsilateral renal agenesis: A rare cause of dysmenorrhoea.  

Science.gov (United States)

Didelphic uterus with obstructed hemivagina and ipsilateral renal agenesis is a rare condition. It usually presents with pelvic pain following the menarche, dysmenorrhoea, and an increase in abdominal volume or a palpable mass due to unilateral haematocolpos. We present the case of a 13-year-old girl who referred with recurrent pelvic pain, mainly at the time of menses, and irregular menstrual cycle complaints in this report. The patient underwent ultrasonography and magnetic resonance (MR) imaging of the pelvis was performed. The diagnosis was uterus didelphys with obstructed hemivagina and ipsilateral renal agenesia. Laparotomy was performed for diagnosis and treatment purposes. Two separated hemiuteri and two cervices with hematometra and hematocolpos on the right side and ipsilateral renal agenesis were detected. The vaginal septum was excised completely and Strassman metroplasty was performed. Her complaints were resolved and she was absolutely asymptomatic after surgery. Diagnosis and management of this congenital anomaly is challenging due to the complexity of the anatomic structures, nonspecific complaints, and heterogenic presentation. These anomalies must always be considered while working-up female patients presenting with episodic abdominal pain and abdominopelvic mass. PMID:24592115

Attar, Rukset; Y?ld?r?m, Gazi; Inan, Yücel; Küz?lkale, Ozge; Karateke, Ate?

2013-01-01

259

[Leiomyoma of the vagina: a report on 2 cases (author's transl)].  

Science.gov (United States)

Two recent cases of vaginal fibroma are reported. These rare lesions are benign, and symptoms, often absent during the early stages, are due to compression from the growing tumor. Treatment is always surgical, the only problem being the most effective approach. This is either by the upper or lower route, depending on the location of the tumor. PMID:7462563

Tramier, D; Marinetti, C; Jouve, M P

1980-01-01

260

High-dose rate brachytherapy (HDRB for primary or recurrent cancer in the vagina  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Purpose The purpose of this study was to evaluate the efficacy of HDR brachytherapy for primary or recurrent vaginal cancer. Methods Between the years 2000 to 2006, 18 patients with primary or recurrent vaginal cancer were treated with brachytherapy (HDRB. Six patients had primary vaginal cancer (stage II to IVA while 12 were treated for isolated vaginal recurrence (primary cervix = 4, vulva = 1 and endometrium = 7. Five patients had previous pelvic radiation therapy. All except one patient received external beam radiation therapy to a median dose of 45 Gy (range 31.2–55.8 Gy. The HDRB was intracavitary using a vaginal cylinder in 5 patients and interstitial using a modified Syed-Nesblett template in 13 patients. The dose of interstitial brachytherapy was 18.75 Gy in 5 fractions delivered twice daily. The median follow-up was 18 months (range 6–66 months. Results Complete response (CR was achieved in all but one patient (94%. Of these 17 patients achieving a CR, 1 had local recurrence and 3 had systemic recurrence at a median time of 6 months (range 6–22 months. The 2-year actuarial local control and cause-specific survival for the entire group were 88% and 82.5%, respectively. In subset analysis, the crude local control was 100% for primary vaginal cancer, 100% for the group with recurrence without any prior radiation and 67% for group with recurrence and prior radiation therapy. Two patients had late grade 3 or higher morbidity (rectovaginal fistula in one patient and chronic vaginal ulcer resulting in bleeding in one patient. Both these patients had prior radiation therapy. Conclusion Our small series suggests that HDRB is efficacious for primary or recurrent vaginal cancer. Patients treated with primary disease and those with recurrent disease without prior irradiation have the greatest benefit from HDRB in this setting. The salvage rate for patients with prior radiation therapy is lower with a higher risk of significant complications. Additional patients and follow-up are ongoing to determine the long-term efficacy of this approach.

Kelley Joseph L

2008-02-01

 
 
 
 
261

Female penis, male vagina, and their correlated evolution in a cave insect.  

Science.gov (United States)

Sex-specific elaborations are common in animals and have attracted the attention of many biologists, including Darwin [1]. It is accepted that sexual selection promotes the evolution of sex-specific elaborations. Due to the faster replenishment rate of gametes, males generally have higher potential reproductive and optimal mating rates than females. Therefore, sexual selection acts strongly on males [2], leading to the rapid evolution and diversification of male genitalia [3]. Male genitalia are sometimes used as devices for coercive holding of females as a result of sexual conflict over mating [4, 5]. In contrast, female genitalia are usually simple. Here we report the reversal of intromittent organs in the insect genus Neotrogla (Psocodea: Prionoglarididae) from Brazilian caves. Females have a highly elaborate, penis-like structure, the gynosome, while males lack an intromittent organ. The gynosome has species-specific elaborations, such as numerous spines that fit species-specific pouches in the simple male genital chamber. During prolonged copulation (~40-70 hr), a large and potentially nutritious ejaculate is transferred from the male via the gynosome. The correlated genital evolution in Neotrogla is probably driven by reversed sexual selection with females competing for seminal gifts. Nothing similar is known among sex-role reversed animals. PMID:24746797

Yoshizawa, Kazunori; Ferreira, Rodrigo L; Kamimura, Yoshitaka; Lienhard, Charles

2014-05-01

262

Impact of Pregnancy and Vaginal Delivery on the Passive and Active Mechanics of the Rat Vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Remodeling of vaginal extracellular matrix and smooth muscle likely plays a critical role in reducing the risk of maternal injury during vaginal delivery by altering the mechanical properties to increase distension and reduce stress. Long-Evans rats were divided into five groups to examine the passive mechanical and active contractile properties throughout pregnancy and postpartum: virgin (n = 17), mid-pregnant (Day 14–16, n = 12), late-pregnant (Day 20–22, n = 14), immediate postpartum (...

2011-01-01

263

The vagina has reducing environment sufficient for activation of Trichomonas vaginalis cysteine proteinases.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

BACKGROUND: Trichomonas vaginalis, a worldwide distributed sexually transmitted protozoan, is remarkable for synthesis of numerous, distinct cysteine proteinases, the significance of which is evidenced by the presence in vivo of soluble proteinases in secretions and antiproteinase antibody in serum of patients with trichomonosis. These proteinases purportedly play a role in host parasitism and immune evasion. OBJECTIVE: It is known that for cysteine proteinases to be functional, they must be ...

Alderete, J. F.; Provenzano, D.

1997-01-01

264

Primary non-clear-cell adenocarcinoma of the vagina in a diethylstilbestrol exposed woman.  

Science.gov (United States)

A 54-year-old woman with a history of in-utero diethylstilbestrol (DES) exposure, who had a prior hysterectomy for symptomatic leiomyomata and dysmenorrhea, presented for vaginal bleeding. Vaginal biopsies showed a non-clear-cell adenocarcinoma, and the patient was subsequently treated with radiation therapy. We present a case of primary vaginal non-clear-cell adenocarcinoma in a patient with in-utero DES exposure. Continued monitoring of older DES-exposed women for vaginal lesions is warranted because of reported cases of non-clear-cell adenocarcinoma and persistent risk of clear cell adenocarcinoma. PMID:24690973

Patel, Samit A; Sunde, Jan

2014-04-01

265

Pelvic Organ Prolapse in Fibulin-5 Knockout Mice : Pregnancy-Induced Changes in Elastic Fiber Homeostasis in Mouse Vagina  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Pelvic organ prolapse is strongly associated with a history of vaginal delivery. The mechanisms by which pregnancy and parturition lead to failure of pelvic organ support, however, are not known. Recently, it was reported that mice with null mutations in lysyl oxidase-like 1 (LOXL1) develop pelvic organ prolapse. Elastin is a substrate for lysyl oxidase (LOX) and LOXL1, and LOXL1 interacts with fibulin-5 (FBLN5). Therefore, to clarify the potential role of elastic fiber assembly in the pathog...

Drewes, Peter G.; Yanagisawa, Hiromi; Starcher, Barry; Hornstra, Ian; Csiszar, Katalin; Marinis, Spyridon I.; Keller, Patrick; Word, R. Ann

2007-01-01

266

Obstructed labour caused by foetal congenital hydronephrosis. Trans-abdominal drainage of the hydronephrosis with resultant delivery per vagina  

Directory of Open Access Journals (Sweden)

Full Text Available A case of a 25 year old 2 alive Patient, with obstructed labour with fetal death and delivery of the fetus up to the trunk caused by congenital Bilateral Hydronephrosis is presented. Obstetric examination on admission supported by Abdominal Ultrasound revealed Bilateral Hydronephrosis which was then drained per abdomen using needle and intravenous fluid giving set with eventual relief of the obstruction and vaginal delivery of the stillborn baby.

Ishaq Funsho Abdul

2013-01-01

267

The Lactobacillus flora in vagina and rectum of fertile and postmenopausal healthy Swedish women  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Lactobacillus species are the most often found inhabitants of vaginal ecosystem of fertile women. In postmenopausal women with low oestrogen levels, Lactobacillus flora is diminishing or absent. However, no studies have been performed to investigate the correlation between oestrogen levels and the lactobacilli in the gut. The aim of the present study was to investigate the relation in healthy women between vaginal and rectal microbial flo...

Gustafsson Rita J; Ahrné Siv; Jeppsson Bengt; Benoni Cecilia; Olsson Crister; Stjernquist Martin; Ohlsson Bodil

2011-01-01

268

Comparative study vagina mould/ fletcher applicator in MRI guided pulsed rate brachytherapy in patients reached by an uterine cervix carcinoma  

International Nuclear Information System (INIS)

This study began in february 2009 and included until today ten patients. twenty patients are planned. The analysis of preliminary results show a much higher tolerance for the vaginal cast device. The dosimetry data were the object of a preliminary study that seems demonstrate an equivalence of the both modalities, with differences concerning the doses to critical organs; The definitive result swill be presented with the data including the twenty planned patients. (N.C.)

2009-10-01

269

Human Papillomavirus Genotyping and E6/E7 mRNA Expression in Greek Women with Intraepithelial Neoplasia and Squamous Cell Carcinoma of the Vagina and Vulva  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A large proportion of vaginal and vulvar squamous cell carcinomas (SCCs) and intraepithelial neoplasias (VAIN and VIN) are associated with HPV infection, mainly type 16. The purpose of this study was to identify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33, and 45) in 56 histology samples of VAIN, VIN, vaginal, and vulvar SCCs. HPV was identified in 56% of VAIN and 50% of vaginal SCCs, 71.4% of VIN and 50% of vulvar SCCs. E6/E7 mRNA expression was found in...

Elpida Tsimplaki; Elena Argyri; Lina Michala; Maria Kouvousi; Aikaterini Apostolaki; George Magiakos; Issidora Papassideri; Efstathia Panotopoulou

2012-01-01

270

Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina)  

Science.gov (United States)

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome refers to the congenital absence or severe hypoplasia of the female genital tract, often described as uterovaginal aplasia which is the prime feature of the syndrome. It is the second cause of primary amenorrhea after gonadal dysgenesis and occurs in ~1 in 4500 women. Aetiology of this syndrome remains poorly understood. Frequent association of other malformations with the MRKH syndrome, involving kidneys, skeleton and ears, suggests the involvement of major developmental genes such as those of the HOX family. Indeed mammalian HOX genes are well known for their crucial role during embryogenesis, particularly in axial skeleton, hindbrain and limb development. More recently, their involvement in organogenesis has been demonstrated notably during urogenital differentiation. Although null mutations of HOX genes in animal models do not lead to MRKH-like phenotypes, dominant mutations in their coding sequences or aberrant expression due to mutated regulatory regions could well account for it. Sequence analysis of coding regions of HOX candidate genes and of PBX1, a likely HOX cofactor during Müllerian duct differentiation and kidney morphogenesis, did not reveal any mutation in patients showing various forms of MRKH syndrome. This tends to show that HOX genes are not involved in MRKH syndrome. However it does not exclude that other mechanisms leading to HOX dysfunction may account for the syndrome.

Burel, Agnes; Mouchel, Thomas; Odent, Sylvie; Tiker, Filiz; Knebelmann, Bertrand; Pellerin, Isabelle; Guerrier, Daniel

2006-01-01

271

Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina)  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome refers to the congenital absence or severe hypoplasia of the female genital tract, often described as uterovaginal aplasia which is the prime feature of the syndrome. It is the second cause of primary amenorrhea after gonadal dysgenesis and occurs in ~1 in 4500 women. Aetiology of this syndrome remains poorly understood. Frequent association of other malformations with the MRKH syndrome, involving kidneys, skeleton and ear...

Burel Agnès; Mouchel Thomas; Odent Sylvie; Tiker Filiz; Knebelmann Bertrand; Pellerin Isabelle; Guerrier Daniel

2006-01-01

272

Carcinoma epidermoide no queratinizante de células grandes y pequeñas en vagina Large and small cells non-keratinizing epidermoid vaginal carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available Se presentan 5 casos clínicos de pacientes atendidas en la consulta de patología de cuello del Hospital Provincial Ginecoobstétrico "Mariana Grajales Coello" de Santiago de Cuba por presentar sangrado vaginal, dolor en bajo vientre, leucorrea y lesiones vaginales. El estudio anatomopatológico confirmó el diagnóstico de carcinoma de células escamosas o epidermoide.Five case reports of patients who were assisted at the cervix Pathology Department from "Mariana Grajales Coello" Provincial Gynecological Obstetrical Hospital in Santiago de Cuba due to vaginal bleeding, low abdominal pain, leukorrhea and vaginal injuries are presented. The pathological study confirmed the diagnosis of squamous or epidermoid cells carcinoma.

Ofelia Masó Anaya

2012-03-01

273

Carcinoma epidermoide no queratinizante de células grandes y pequeñas en vagina / Large and small cells non-keratinizing epidermoid vaginal carcinoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se presentan 5 casos clínicos de pacientes atendidas en la consulta de patología de cuello del Hospital Provincial Ginecoobstétrico "Mariana Grajales Coello" de Santiago de Cuba por presentar sangrado vaginal, dolor en bajo vientre, leucorrea y lesiones vaginales. El estudio anatomopatológico confir [...] mó el diagnóstico de carcinoma de células escamosas o epidermoide. Abstract in english Five case reports of patients who were assisted at the cervix Pathology Department from "Mariana Grajales Coello" Provincial Gynecological Obstetrical Hospital in Santiago de Cuba due to vaginal bleeding, low abdominal pain, leukorrhea and vaginal injuries are presented. The pathological study confi [...] rmed the diagnosis of squamous or epidermoid cells carcinoma.

Ofelia, Masó Anaya; María Elena, Morales Larramendi; Dolores, Díaz Pérez; Esperanza, Dager Dager; Gloria Adelaida, Bolaños Diego.

274

Penetrating injury of the vagina, bladder and omentum in a woman with 5 months gestation: case report and review of the literature.  

Science.gov (United States)

Intra-peritoneal bladder and visceral injuries from impalement of the perineum in women are exceedingly rare. This kind of injury has not been previously reported in a pregnant woman. The evaluation and surgical management of a pregnant woman is a challenging surgical problem. Preoperative evaluation of the uterus and fetus is balanced with minimal use of radiographic studies. Multiple organs can be damaged with this type of injury, necessitating careful evaluation and operative planning. We report a rare case of transvaginal impalement injury with through-and-through bladder rupture and intra-peritoneal injury in a 5 months pregnant woman. We discuss diagnostic and management strategies and review the literature. PMID:24366762

Zhang, Chao; Liu, Qiang; Li, Bo-Jun; Bi, Gang; Yi, Ping; Li, Ke; Zhang, Yong; Zhang, Ke-Qin; Li, Yan-Feng

2014-06-01

275

Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina)  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome refers to the congenital absence or severe hypoplasia of the female genital tract, often described as uterovaginal aplasia which is the prime feature of the syndrome. It is the second cause of primary amenorrhea after gonadal dysgenesis and occurs in ~1 in 4500 women. Aetiology of this syndrome remains poorly understood. Frequent association of other malformations with the MRKH syndrome, involving kidneys, skeleton and ears, suggests the inv...

Burel, Agne?s; Mouchel, Thomas; Odent, Sylvie; Tiker, Filiz; Knebelmann, Bertrand; Pellerin, Isabelle; Guerrier, Daniel

2006-01-01

276

Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract The Mayer-Rokitansky-Küster-Hauser (MRKH syndrome refers to the congenital absence or severe hypoplasia of the female genital tract, often described as uterovaginal aplasia which is the prime feature of the syndrome. It is the second cause of primary amenorrhea after gonadal dysgenesis and occurs in ~1 in 4500 women. Aetiology of this syndrome remains poorly understood. Frequent association of other malformations with the MRKH syndrome, involving kidneys, skeleton and ears, suggests the involvement of major developmental genes such as those of the HOX family. Indeed mammalian HOX genes are well known for their crucial role during embryogenesis, particularly in axial skeleton, hindbrain and limb development. More recently, their involvement in organogenesis has been demonstrated notably during urogenital differentiation. Although null mutations of HOX genes in animal models do not lead to MRKH-like phenotypes, dominant mutations in their coding sequences or aberrant expression due to mutated regulatory regions could well account for it. Sequence analysis of coding regions of HOX candidate genes and of PBX1, a likely HOX cofactor during Müllerian duct differentiation and kidney morphogenesis, did not reveal any mutation in patients showing various forms of MRKH syndrome. This tends to show that HOX genes are not involved in MRKH syndrome. However it does not exclude that other mechanisms leading to HOX dysfunction may account for the syndrome.

Pellerin Isabelle

2006-03-01

277

Vaginal Cancer  

Science.gov (United States)

... a roadmap to this full guide. About the vagina The vagina or birth canal is the opening through which ... folds of skin around its opening). Usually, the vagina is in a collapsed position with its walls ...

278

Vaginal Anomalies: Congenital Vaginal Obstruction  

Science.gov (United States)

... is usually due to incomplete canalization of the vagina during development. Either of these can result in hydrocolpos, an abnormal swelling of the vagina, or hydrometrocolpos, abnormal swelling of both the vagina ...

279

Hysterectomy  

Science.gov (United States)

... vaginal hysterectomy, the uterus is removed through the vagina . Because the incision is inside the vagina, the ... contains and nourishes the developing fetus during pregnancy. Vagina: A tube-like structure surrounded by muscles leading ...

280

Surgery for Vaginal Cancer  

Science.gov (United States)

... used to treat squamous cell cancers of the vagina, but it is used for sarcomas and melanomas. ... nodes. Vaginectomy Vaginectomy is surgery to remove the vagina. If only part of the vagina is removed, ...

 
 
 
 
281

Vaginal and Vulvar Cancer  

Science.gov (United States)

Vagina Fallopian Tubes Ovaries Uterus Cervix Vulva Vaginal and Vulvar Cancer Get the Facts About Gynecologic Cancer ... body parts later. When cancer starts in the vagina, it is called vaginal cancer. The vagina, also ...

282

40 CFR 79.63 - Fertility assessment/teratology.  

Science.gov (United States)

...condition of the cells present in the vagina and the presence or absence of various...kidneys, adrenals, pituitary, uterus, vagina, ovaries, testes, epididymides and...Histopathology. (A) Histopathology on vagina, uterus, ovaries, testes,...

2010-07-01

283

What Is Vaginal Cancer?  

Science.gov (United States)

... about vaginal cancer? What is vaginal cancer? The vagina The vagina is a 3- to 4-inch ( ... refers only to cancers that start in the vagina, also known as primary vaginal cancers. Last Medical ...

284

Robot-Assisted Gynecologic Oncology Surgery  

Medline Plus

Full Text Available ... the junction between the cervix and the upper vagina. And I'm trying to -- sometimes it's really ... to start a colpotomy, which is opening the vagina, separating the cervix from the vagina. 00:27: ...

285

Vaginal Birth  

Medline Plus

Full Text Available ... the cervix and vagina and comes out! The path the baby travels through is called the birth ... cervix and vagina to the outside world! The path the baby travels through is called the birth ...

286

Ovarian Cancer  

Medline Plus

Full Text Available ... in front of the vagina and uterus. The kidneys drain the urine into the bladder through 2 ... located above and behind the vagina and uterus. Kidney Bladder Urethra Ureter Cancer and its Causes The ...

287

Pelvic Organ Prolapse  

Medline Plus

Full Text Available ... loss of urine while coughing, sneezing, or laughing). Rectal prolapse into the vagina (rectocele) The rectum drops ... with bladder prolapse (shown here) or rectal prolapse. Rectal prolapse into the vagina (rectocele) The rectum can ...

288

Cervical Cancer  

Science.gov (United States)

CervicalCancer Vagina Fallopian Tubes Ovaries Uterus Cervix Vulva Get the Facts About Gynecologic Cancer There are five main types ... end of the uterus. The cervix connects the vagina (the birth canal) to the upper part of ...

289

Barrier Methods of Contraception  

Science.gov (United States)

... that melts after it is inserted in the vagina ), or film (thin sheets). Spermicide can be used ... contains and nourishes the developing fetus during pregnancy. Vagina: A tube-like structure surrounded by muscles leading ...

290

Ovarian Cancer  

Science.gov (United States)

Vagina Fallopian Tubes Ovaries Uterus Cervix Vulva OvarianCancer Get the Facts About Gynecologic Cancer There are five ... you are past menopause) or discharge from your vagina that is not normal for you. • Pain or ...

291

Ovarian Cancer Screening  

Science.gov (United States)

... include the uterus, ovaries, fallopian tubes, cervix, and vagina. The uterus has a muscular outer layer called ... A pelvic exam is an exam of the vagina , cervix , uterus , fallopian tubes , ovaries , and rectum . The ...

292

Condom  

Science.gov (United States)

... this happens, sperm could enter the vagina. Female Condom The female condom is inserted into the vagina ... to slip during intercourse, making them ineffective. Continue Condom Precautions Once a condom is used, it cannot ...

293

Vaginal Birth  

Medline Plus

Full Text Available ... rectum. The female reproductive organs include: 1. The vagina 2. The cervix 3. The uterus 4. The ... is called the cervix. It opens into the vagina, which opens to the outside of the body ...

294

Uterine Sarcoma Treatment (PDQ): Treatment Options by Stage  

Science.gov (United States)

... end of the uterus, and leads to the vagina . Enlarge Anatomy of the female reproductive system. The ... include the uterus, ovaries, fallopian tubes, cervix, and vagina. The uterus has a muscular outer layer called ...

295

Pelvic Organ Prolapse  

Medline Plus

Full Text Available ... coughing, sneezing, or laughing). Rectal prolapse into the vagina (rectocele) The rectum drops down and creates a ... here) or rectal prolapse. Rectal prolapse into the vagina (rectocele) The rectum can drop downward, creating a ...

296

Amniocentesis  

Medline Plus

Full Text Available ... sample of placenta tissue is taken through the vagina or the abdomen. The test can be done ... C • Dizziness • Bleeding or fluid leakage from your vagina or from where the needle was inserted • Redness ...

297

Types of Hymens  

Science.gov (United States)

... thin membrane that surrounds the opening to the vagina. Hymens can come in different shapes. The most ... menstrual blood to flow out of a girl's vagina. Imperforate hymen : An imperforate hymen can be diagnosed ...

298

C-Section  

Medline Plus

Full Text Available ... 5 The female reproductive organs include: 1. The vagina 2. The cervix 3. The uterus 4. The ... is called the cervix. It opens into the vagina, which opens to the outside of the body ...

299

Uterine Fibroids  

Medline Plus

Full Text Available ... their causes, symptoms, diagnosis, and treatment options. Anatomy Vagina Uterus Fallopian Tubes Ovaries The female reproductive organs include: • the vagina • the uterus • the fallopian tubes • the ovaries The ...

300

Two Surgeries for Pelvic Prolapse Found Similarly Effective, Safe  

Science.gov (United States)

... At left, from left to right, the bladder, vagina, and rectum as they would normally appear. At ... the pelvic cavity and is pressing on the vagina, causing the vaginal wall to protrude partially through ...

 
 
 
 
301

Hysterectomy  

Medline Plus

Full Text Available ... risks of this surgery. Ovaries Fallopian Tubes Uterus Vagina Anatomy This document is a summary of what ... 18/2009 1 The female reproductive organs include: • Vagina • Uterus • Fallopian tubes • And ovaries. These organs are ...

302

Bladder Cancer (PDQ): Treatment  

Science.gov (United States)

... Lower back pain. Tests that examine the urine, vagina, or rectum are used to help detect (find) ... be taken. Internal exam : An exam of the vagina and/or rectum . The doctor inserts gloved fingers ...

303

HIV and AIDS  

Medline Plus

Full Text Available ... mucous membranes of the mouth, tongue, esophagus or vagina. Cryptococcal meningitis causes inflammation of the membranes and ... The cervix is the opening that separates the vagina from the uterus. Non Hodgkin's lymphoma is cancer ...

304

Ultrasound -- Pelvis  

Medline Plus

Full Text Available ... involves the insertion of the transducer into the vagina after you empty your bladder. The tip of ... amount of gel, and then inserted into the vagina. Only two to three inches of the transducer ...

305

Robotic-Assisted Laparoscopic Sacrocolpopexy for Vaginal Vault Prolapse  

Medline Plus

Full Text Available ... surgically correct vaginal vault prolapse by resupporting the vagina to the sacrum using a polypropylene mesh. Dr. ... they were not at all attached to the vagina. I'm going to orient you to the ...

306

Laparoscopic Supracervical Hysterectomy  

Medline Plus

Full Text Available ... end of the uterus which attaches to the vagina and empties into the vaginal area. We discussed ... in place, you support the top of the vagina better. And we have…we believe that we ...

307

Pap Smear  

Medline Plus

Full Text Available ... why it is beneficial. Ovaries Fallopian Tubes Uterus Vagina Anatomy This document is for informational purposes and ... 2012 1 The female reproductive organs include: • The vagina • The uterus • The Fallopian tubes • The ovaries These ...

308

Colposcopy  

Medline Plus

Full Text Available ... its indications, and possible risks and complications. Anatomy Vagina Uterus Fallopian Tubes Ovaries The female reproductive organs include: • the vagina • the uterus • the Fallopian tubes • the ovaries The ...

309

Robotic-Assisted Hysterectomy  

Medline Plus

Full Text Available ... it lets me make my vaginotomy access the vagina much more easily, and as long as I ... actually don't remove the uterus from the vagina, you remove the uterus from an incision in ...

310

Endometriosis  

Medline Plus

Full Text Available ... understand endometriosis better and review some treatment options. Vagina Uterus Fallopian Tubes Ovaries Anatomy The female reproductive organs include: • the vagina • the uterus • the fallopian tubes • the ovaries The ...

311

Butoconazole Vaginal Cream  

Science.gov (United States)

... is used to treat yeast infections of the vagina.This medication is sometimes prescribed for other uses; ... comes as a cream to insert into the vagina. It is usually used daily at bedtime. Follow ...

312

Sexually Transmitted Diseases  

Medline Plus

Full Text Available ... women, herpes sores could be hidden inside the vagina. Some women may not even know that they ... common symptoms of gonorrhea are: • Discharge from the vagina or penis This document is for informational purposes ...

313

Crohn's Disease  

Medline Plus

Full Text Available ... area into surrounding tissues such as the bladder, vagina, or skin. These tunnels, called fistulae, often become ... and the bladder, or the intestines and the vagina or the colon and the outside. If fistulae ...

314

Surgical Tutorial of a Robotic-Assisted Anterior Pelvic Exenteration  

Medline Plus

Full Text Available ... anterior portion of the cervix and the anterior vagina and it invading into the posterior bladder. To ... remove the bladder, the anterior part of the vagina, the cervix and surrounding tissues as well last ...

315

Laparo-Endoscopic Single-Site (LESS) Procedure  

Medline Plus

Full Text Available ... great results that having to go through the vagina or through the stomach, it just doesn't ... a hysterectomy, and everything is extracted through the vagina -- or the chole and anti-reflux operation. Before ...

316

Ovarian Cysts  

Medline Plus

Full Text Available ... and how they may be diagnosed and treated. Vagina Uterus Fallopian Tubes Ovaries Anatomy The female reproductive organs include: • the vagina • the uterus • the fallopian tubes • the ovaries The ...

317

Robotic-Assisted Hysterectomy for Endometrial Cancer  

Medline Plus

Full Text Available ... we have time, when we sew on the vagina we’re using just a traditional suture material. ... is no worry about cautery damage to the vagina. There isn’t significant heat within the vaginal ...

318

Ovarian Cancer  

Medline Plus

Full Text Available ... 1 Anatomy The female reproductive organs include: • The vagina • The uterus • The fallopian tubes • The ovaries. The ... release of eggs that are needed for reproduction. Vagina Uterus Fallopian Tubes Ovaries The other main function ...

319

Dilation and Curettage  

Medline Plus

Full Text Available ... that can be treated or diagnosed with it. Vagina Uterus Fallopian Tubes Ovaries Anatomy The female reproductive organs include: • the vagina • the uterus • the fallopian tubes • the ovaries The ...

320

Robot-Assisted Gynecologic Oncology Surgery  

Medline Plus

Full Text Available ... it slides through, make sure you have our Foley balloon in to maintain our pneumo. 00:37: ... the vagina. And she's going to place a Foley balloon now in the vagina, because we're ...

 
 
 
 
321

Pelvic Organ Prolapse  

Medline Plus

Full Text Available ... while coughing, sneezing, or laughing). Rectal prolapse into the vagina (rectocele) The rectum drops down and creates ... shown here) or rectal prolapse. Rectal prolapse into the vagina (rectocele) The rectum can drop downward, creating ...

322

Uterine Fibroids  

Medline Plus

Full Text Available ... options. Anatomy Vagina Uterus Fallopian Tubes Ovaries The female reproductive organs include: • the vagina • the uterus • the fallopian tubes • the ovaries The female reproductive organs are located in the pelvis, between ...

323

Dilation and Curettage  

Medline Plus

Full Text Available ... it. Vagina Uterus Fallopian Tubes Ovaries Anatomy The female reproductive organs include: • the vagina • the uterus • the fallopian tubes • the ovaries The female reproductive organs are located in the pelvis, between ...

324

Vaginal Birth  

Medline Plus

Full Text Available ... widened cervix, through the vagina to the outside world! This is the when the mother pushes with ... through the cervix and vagina to the outside world! The path the baby travels through is called ...

325

Surgical Tutorial of a Robotic-Assisted Anterior Pelvic Exenteration  

Medline Plus

Full Text Available ... anterior vagina and it invading into the posterior bladder. To make matters a little more complicated, she ... is not involved, we would surgically remove the bladder, the anterior part of the vagina, the cervix ...

326

Crohn's Disease  

Medline Plus

Full Text Available ... affected area into surrounding tissues such as the bladder, vagina, or skin. These tunnels, called fistulae, often ... be a connection between the intestines and the bladder, or the intestines and the vagina or the ...

327

Vaginitis test - wet mount  

Science.gov (United States)

... the provider can see inside. A sterile, moist cotton swab is gently inserted into the vagina to ... Eckert LO, Lentz GM. Infections of the lower and upper genital tracts: vulva, vagina, cervix, toxic shock syndrome, endometritis, and salpingitis. In: Lentz ...

328

How Is Cervical Cancer Staged?  

Science.gov (United States)

... the pelvis or the lower part of the vagina. The cancer may have grown into the upper part of the vagina. T2a : The cancer has not spread into the ... has spread to the lower part of the vagina or the walls of the pelvis. The cancer ...

329

21 CFR 884.4520 - Obstetric-gynecologic general manual instrument.  

Science.gov (United States)

...expose and illuminate the interior of the vagina. (3) A metal vaginal speculum is...instrument used to expose the interior of the vagina. (4) An umbilical scissors is a...introduce dressing into the uterus or vagina. (7) A vaginal applicator is an...

2009-04-01

330

21 CFR 250.108 - Potassium permanganate preparations as prescription drugs.  

Science.gov (United States)

...crystals of potassium permanganate into the vagina. Experience with these cases shows...and painful injury to the walls of the vagina, causing ulcers, massive hemorrhage...any mucous membranes or for use in the vagina will be regarded as misbranded under...

2010-04-01

331

21 CFR 884.4530 - Obstetric-gynecologic specialized manual instrument.  

Science.gov (United States)

...material from the surface of the cervix or vagina. (14) A gynecological biopsy forceps...pelvimeter is an instrument used within the vagina to measure the diameter and capacity of...instrument used to expose the interior of the vagina. (18) A fiberoptic nonmetal...

2009-04-01

332

Development of vesicovaginal fistula caused by vaginal adenosis: A case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Introduction: Vaginal adenosis is one of the rare diseases of the vagina, and almost all patients are asymptomatic. We report a case of spontaneous vaginal adenosis, which caused vesicovaginal fistula. Case Presentation: Our patient was a 25-year-old Japanese woman. She was admitted to our hospital, and her chief complaint was continuous urine flow from the vagina. We found a tumor with a vesicovaginal fistula in her vagina. Subsequent cytological a...

2013-01-01

333

The normal microflora of the female rabbit's genital tract.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Microorganisms associated with the vagina, cervix and uterus of rabbits were isolated and identified. The predominant microorganisms isolated from the vaginas and cervices were coagulase-negative staphylococci, micrococci, and nonfermentative bacilli. Coagulase-negative staphylococci were isolated frequently, but in small numbers, from the uteri. The pH of the rabbit vagina was found to be near neutrality. Our data indicate that the genital flora of female rabbits is relatively simple, regard...

Jacques, M.; Olson, M. E.; Crichlow, A. M.; Osborne, A. D.; Costerton, J. W.

1986-01-01

334

Nystatin  

Science.gov (United States)

Nystatin® Cream ... Nystatin® Ointment ... Nystatin® Powder ... Nystatin® Suspension ... Nystatin® Vaginal Tablets ... Nystatin is used to treat fungal infections of the skin, mouth, vagina, and intestinal tract. Fungal medicines ...

335

Colpopéxia transcoccígea con malla de polipropileno con orificios facilitadores de la integración en la corrección del prolapso de la pared posterior de la vagina: resultados anatómicos y funcionales / Transcoccigeal colpopexy with polyprolylene mesh with helper orifices for the treatment of posterior vaginal wall prolapse: anatomical and functional results  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: La creación de neoligamentos útero- sacros, según lo descripto por Petros, con el uso de malla sintética de polipropileno permite la corrección anatómica del prolapso posterior en los tres niveles propuestos por DeLancey. El objetivo de este estudio es evaluar los resultados anatómicos y f [...] uncionales de este método en la corrección del POP posterior. Pacientes y método: Desde diciembre del 2004 a marzo del 2007, 34 mujeres con edad media de 63 años fueron sometidas al procedimiento, siendo rectoceles grado III o mayores. El seguimento mínimo fué de 13 meses. Los puntos de fijación fueron el músculo íleococcígeo y el ligamento sacroespinoso. Técnica: Luego de la incisión de la mucosa de la pared vaginal posterior, la fosa ísquio-rectal es disecada. Dos pequeñas incisiones son hechas 3 cm lateral y 3 cm inferior al ano. La aguja se inserta verticalmente en dirección a la espina isquiática, guiado por el dedo indicador del cirujano hasta el ligamento sacroespinoso, 2 cm medialmente, evitando a lesión del canal de Alcock. Los brazos de la malla son conectados a la punta de la aguja, traccionando posteriormente de las agujas. No se realiza la correción sitio específica. El exceso de malla es recortado y esta se fija próxima al cuerpo perineal, quedando de esa forma extendida sobre la pared vaginal posterior. La mucosa vaginal se cierra en forma habitual. Resultados: Con el 94,7% de cura y recurrencia del 5,3%, no hubo lesión nerviosa, visceral o vascular. Cinco (14,7%) pacientes tuvieron exposición de la malla de menos de 1 cm² y fueron tratadas conservadoramente sin impacto en los resultados. Dos de las 17 sexualmente activas (11,8%) presentaron dispareunia transitoria, siendo prolongada en 1 solo caso (5,9%) Conclusión: Este procedimiento mínimamente invasivo es una alternativa atractiva para la reconstrucción anatómica y funcional de los defectos posteriores y apicales. Abstract in english Objective: The creation of neo utero-sacral neoligaments, decribed by Petros, evolved into a new procedure allowing for the anatomical reconstruction of the three levels proposed by DeLancey. The aim of this study is evaluate the anatomical and functional outcomes of this minimally invasive procedur [...] e. Patients and method: From December 2004 to March 2007, a total of 34 patients with posterior defect grade III or higher underwent this procedure. The minimum follow up was 13 months Mean age was 63 years. The site of fixation was the Sacrospinous ligament. Surgical technique: The ischiorectal fossa is dissected. Next two small skin incisions are made 3 cm lateral and inferior to the center of the anus. A proper needle is introduced, vertically towards the sacrospinal ligament at the level of the ischial spine, guided by the surgeon index finger, 2 cm medially avoiding the Alcok canal. The armpit of the mesh is connected to the tip of the needle and brought to the perineal region. No site specific correction is made. Results: The cure rate was 94,7% and recurrence rate was 5,3%. No visceral, nerurovascular injuries were observed. The mesh exposure rate (less than 1 cm²) was (14.7%) and all patients were treated conservatively with no impact on the outcome. There were transient dyspareunia in 2 (11.8%) of the 17 sexually active patient and persistent in 1 case (5.9%). Conclusions: This procedure is an attractive minimally invasive alternative for the anatomical and functional reconstruction of the posterior and apical defects.

Pagotto, Vitor; Palma, Paulo; Riccetto, Cassio; Bigozzi, Miguel.

336

Comparative study vagina mould/ fletcher applicator in MRI guided pulsed rate brachytherapy in patients reached by an uterine cervix carcinoma; Etude comparative moule vaginal/applicateur de fletcher en curietherapie de debit pulse guide par IRM chez les patientes atteintes d'un cancer du col uterin  

Energy Technology Data Exchange (ETDEWEB)

This study began in february 2009 and included until today ten patients. twenty patients are planned. The analysis of preliminary results show a much higher tolerance for the vaginal cast device. The dosimetry data were the object of a preliminary study that seems demonstrate an equivalence of the both modalities, with differences concerning the doses to critical organs; The definitive result swill be presented with the data including the twenty planned patients. (N.C.)

Francois, G.; Dumas, I.; Mazeron, R.; Verezesan, O.; Monnier, L.; Vieillot, S.; Gensse, M.C.; Haie-Meder, C. [Institut Gustave-Roussy, 94 - Villejuif (France)

2009-10-15

337

EIGHTEEN YEARS OLD VESICO-VAGINAL FISTULA CAUSED BY FORCEPS DELIVERY: A SAGA OF SUFFERING  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Vesicovaginal Fistula (VVF), also called 'obstetric fistula', is an abnormal fistulous tract that extends from the urinary bladder (‘vesico’) to the vagina, resulting in an involuntary continuous discharge of urine into the vagina (urinary incontinence). It most commonly results from neglected and obstructed labor. Here we report a case of VVF with 18 years of distressing urinary incontinence after a difficult forceps delivery.

Surekha Tayade; Naina Kumar

2012-01-01

338

Female Genital Cutting  

Science.gov (United States)

... normally. The most severe form of FGC leaves women with scars that cover most of their vagina. This makes sex very ... able to achieve sexual intercourse. The scar that covers the vagina makes this very difficult. Once pregnant, a woman can have drawn out labor, tears, heavy bleeding, ...

339

Labial flap vaginoplasty with sacrospinous fixation  

Directory of Open Access Journals (Sweden)

Full Text Available We present a case of congenital absence of Vagina which was treated by reconstruction of the vagina using vascular labial flaps. Furthermore, we anchored the neo-vagina to the Sacro-spinous ligament on either side. The aim of the attachment to the sacro-spinous ligament is to provide a durable apical support and to give an immediate, good vaginal length. Various techniques have been described for the construction of Neo-vagina. Except for sigmoid vaginoplasty, most other procedures are associated with a significant risk of post-operative re-stenosis, for which prolonged dilatation is necessary. Attaching to the sacro-spinous ligament gives the vagina good depth and, to some extent, decreases the risk of re-stenosis. This technique is simpler, does not require sophisticated instruments or prolonged post operative dilatation and is particularly suitable for under-developed countries.

Chandrashekar Murthy

2010-12-01

340

Wnt family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol exposure in mice  

International Nuclear Information System (INIS)

Proliferation and differentiation of cells in female reproductive organs, the oviduct, uterus and vagina, are regulated by endogenous estrogen. In utero exposure to a synthetic estrogen, diethylstilbestrol (DES), induces vaginal clear-cell adenocarcinoma in humans. In mice, perinatal exposure to DES results in abnormalities such as polyovular follicles, uterine circular muscle disorganization and persistent vaginal epithelial cell proliferation. We reported the persistent gene expression change such as interleukin-1 (IL-1) related genes, insulin-like growth factor-I (IGF-I) and its downstream signaling in the mouse vagina exposed neonatally to DES. In this study, we found persistent up-regulation of Wnt4 and persistent down-regulation of Wnt11 in the vagina of mice exposed neonatally to DES and estrogen receptor ? specific ligand. Also Wnt4 expression in vagina is correlated to the stratification of epithelial cells with the superficial keratinization of vagina, but not epithelial cell stratification only.

2012-06-14

 
 
 
 
341

A Case of Transverse Vaginal Septum Diagnosed During Labor  

Directory of Open Access Journals (Sweden)

Full Text Available Transverse vaginal septum is the result of faulty canalization of the embryonic vagina. We described a case of transverse vaginal septum with a small central aperture diagnosed during labor. An 18-years-old girl at 28 weeks of gestation presented to our obstetric department complaining of symptoms of preterm delivery. Pelvic and vaginal ultrasonography, with gynecologic examination established a diagnosis of transverse vaginal septum in mid-vagina. An incision in the vaginal septum allowed us to see the head of the fetus in the vagina. The diagnosis of transverse vaginal septum was confirmed during labor and excision of the septum prevented the uterine rupture.

Üstün, Y.

2005-01-01

342

Rectal occurrence of Mobiluncus species.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The simultaneous occurrence of Mobiluncus spp in the vagina and rectum was studied in women attending a sexually transmitted diseases (STD) department. Of 43 women with bacterial vaginosis (BV), 32 had Mobiluncus spp in the vagina and 23 in the rectum. In 20 women the same Mobiluncus species was found concomitantly in the vagina and the rectum. Mobiluncus spp were found in the rectum only in two women with BV, one with candidal vaginitis, and one healthy woman. In a treatment study of 23 wome...

Halle?n, A.; Pa?hlson, C.; Forsum, U.

1988-01-01

343

Vaginoplasty with a Pudendal-Thigh Flap in Intersexuals  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We treated 2 different types of intersexual patients who underwent a vaginoplasty with the pudendal-thigh flap. One was a female with testicular feminization syndrome for whom we reconstructed the total vagina with a pudendal-thigh flap, and the other was a female with an adrenogenital syndrome for whom we enlarged the introitus of the vagina with the same approach. There were no complications such as a flap necrosis. In addition, there was no stricture of the neo-vagina and no urinary pro...

Namba, Yuzaburo; Sugiyama, Narushi; Yamashita, Shuji; Hasegawa, Kenjiro; Kimata, Yoshihiro; Nakatsuka, Mikiya

2008-01-01

344

Vaginoplasty with a Pudendal-Thigh Flap in Intersexuals  

Directory of Open Access Journals (Sweden)

Full Text Available We treated 2 different types of intersexual patients who underwent a vaginoplasty with the pudendal-thigh flap. One was a female with testicular feminization syndrome for whom we reconstructed the total vagina with a pudendal-thigh flap, and the other was a female with an adrenogenital syndrome for whom we enlarged the introitus of the vagina with the same approach. There were no complications such as a flap necrosis. In addition, there was no stricture of the neo-vagina and no urinary problem.

Nakatsuka,Mikiya

2008-12-01

345

Ovarian Cancer  

Medline Plus

Full Text Available ... urine into the bladder through 2 tubes called ureters. The intestines and rectum are located above and behind the vagina and uterus. Kidney Bladder Urethra Ureter Cancer and its Causes The body is made ...

346

Menopause  

Medline Plus

Full Text Available ... reduced estrogen levels may cause other long-term effects on your body in organs such as the: • bones • heart • vagina • bladder • skin Bones Menopause can weaken your bones, a condition ...

347

32 CFR 199.4 - Basic program benefits.  

Science.gov (United States)

...primarily to improve physical appearance or that is performed...concomitant improvement in physical appearance, the surgical procedure...vagina in a biological male who had undergone transsexual...developmental, mental, or physical disabilities or...

2010-07-01

348

Laparo-Endoscopic Single-Site (LESS) Procedure  

Medline Plus

Full Text Available ... a chole and a hysterectomy, and everything is extracted through the vagina -- or the chole and anti- ... in. The idea simply is to not have dye (inaudible). But there's no reason that cholangiography can' ...

349

Crohn's Disease  

Medline Plus

Full Text Available ... surrounding tissues such as the bladder, vagina, or skin. These tunnels, called fistulae, often become infected. Usually ... Other problems associated with Crohn's Disease include: • arthritis • skin problems such as rashes and sores • inflammation in ...

350

Hysterectomy  

Medline Plus

Full Text Available ... in front of the vagina and uterus. The kidneys drain the urine into the bladder through 2 ... is very rare for the tubes connecting the kidneys to the bladder, as well as the bladder ...

351

Endometriosis  

Medline Plus

Full Text Available ... in front of the vagina and uterus. The kidneys drain urine into the bladder through 2 tubes ... sure that other diseases, such as infections or kidney problems, are not the reason for the symptoms. ...

352

Robot-Assisted Hysterectomy  

Medline Plus

Full Text Available ... balloon that we slide into the vagina. The reason we do so is that once we create ... I think there’s definitely, you know, a couple reasons to go to Da Vinci now with – in ...

353

Liposuction  

Science.gov (United States)

... thus allowing easier access to the vagina. Body shaping for people who are bothered by fatty bulges ... after surgery to help prevent blood clots from forming in your legs. Avoid more strenuous exercise for ...

354

Robot-Assisted Gynecologic Oncology Surgery  

Medline Plus

Full Text Available ... 57 KELLY L. MOLPUS, MD: Yes. Hold that steady, please. 00:28:06 CHRISTOPHER STANLEY, MD: In ... vagina. And usually with a little bit of steady motion and rocking, we can get that taken ...

355

?????????: S00689  

Full Text Available Musa paradisiaca Fructus Pisang BANANA, PLANTAIN Fruit Bleeding uterus, vagina close up, sprue b liver), colon bleeding, diarrhea - http://www.iptek.net .id/ind/pd_tanobat/ Musa paradisiaca

356

?????????: S00690  

Full Text Available Musa paradisiaca Radix Pisang BANANA, PLANTAIN Root Bleeding uterus, vagina close up, sprue bowe liver), colon bleeding, diarrhea - http://www.iptek.net .id/ind/pd_tanobat/ Musa paradisiaca

357

Crohn's Disease  

Medline Plus

Full Text Available ... intestines Crohn's Disease can also cause sores that tunnel through the affected area into surrounding tissues such as the bladder, vagina, or skin. These tunnels, called fistulae, often become infected. Usually fistulae are ...

358

Sexually Transmitted Diseases  

Medline Plus

Full Text Available ... sign of herpes is painful blisters or open sores in the genital area. Before these show up, ... genital region, legs, or buttocks. In women, herpes sores could be hidden inside the vagina. Some women ...

359

Vaginal Birth  

Medline Plus

Full Text Available ... the healthcare provider thinks it may rip or tear the vagina, he or she may make a ... easier to sew and heals better than a tear. Not all healthcare providers believe in the benefits ...

360

Vaginal yeast infection  

Science.gov (United States)

Yeast infection - vagina; Vaginal candidiasis; Monilial vaginitis ... Most women have a vaginal yeast infection at some time. Candida albicans is a common type of fungus. It is often found in small amounts in the ...

 
 
 
 
361

Robotic-Assisted Hysterectomy for Endometrial Cancer  

Medline Plus

Full Text Available ... GEHRIG, MD: We have a question regarding nerve damage and how do we avoid that with this ... heat so there is no worry about cautery damage to the vagina. There isn’t significant heat ...

362

HISTOLOGÍA URETRAL Y VAGINAL EN ALGUNAS HEMBRAS DE MAMÍFEROS  

Directory of Open Access Journals (Sweden)

Full Text Available El análisis de las características histológicas de la uretra y la vagina en hembras de mamíferos es útil para entender la fisiología y la patología de procesos como la continencia urinaria, la cópula y el parto. En este contexto, las especies más estudiadas en cuanto a la organización tisular de la uretra y vagina son la rata y la coneja. Es necesario estudiar con más detalle la organización tisular de la vagina y uretra en diferentes especies con fines de comparación. Tal información permitiría entender la diversidad funcional y conductual asociada a estos órganos. El presente documento reúne, compara y discute la información existente sobre las características histológicas de la uretra y la vagina en algunas hembras de mamíferos destacando aquellas de la coneja, modelo utilizado por nuestro grupo de investigación para estudiar la fisiología reproductiva y urinaria femenina.

J Rodru00EDguez-Antolu00EDn

2012-01-01

363

Vaginal Birth  

Medline Plus

Full Text Available ... The vagina 2. The cervix 3. The uterus 4. The Fallopian tubes 5. The ovaries When an ... cervix is 10 centimeters wide. This is about 4 inches. This is when the mother is asked ...

364

Amniocentesis  

Medline Plus

Full Text Available ... you develop any of the following symptoms. • Moderate to severe abdominal pain or cramping • Chills or a fever higher than 100 °F or 38 °C • Dizziness • Bleeding or fluid leakage from your vagina ...

365

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... catheter. And now we're starting to drive down into the artery that goes to the uterus. ... And this is the cervix and the vagina down here. So most of these fibroids that grows ...

366

Pelvic Organ Prolapse  

Medline Plus

Full Text Available ... a greater distance. Uterine prolapse The uterus drops down into the vagina. In severe uterine prolapse, the ... rectal prolapse. Bladder prolapse (cystocele) The bladder drops down and creates a bulge into the front wall ...

367

Robotic-Assisted Laparoscopic Sacrocolpopexy for Vaginal Vault Prolapse  

Medline Plus

Full Text Available ... to get a really good attachment pretty far down. If you could deviate the vaginal EEA towards ... pushing it in. So we've dissected this down a fair amount down the anterior vagina so ...

368

Hysterectomy  

Science.gov (United States)

... Injury to the urinary tract or nearby organs • Deep vein thrombosis (DVT) , which is a risk with any surgery • Problems ... the uterus at the top of the vagina. Deep Vein Thrombosis (DVT): A condition in which a blood clot ...

369

HIV and AIDS  

Medline Plus

Full Text Available ... causes a thick, white coating on the mucous membranes of the mouth, tongue, esophagus or vagina. Cryptococcal meningitis causes inflammation of the membranes and fluid around the brain and spinal cord. ...

370

Laparoscopic Supracervical Hysterectomy  

Medline Plus

Full Text Available ... The cervix is the little organ at the end of the uterus which attaches to the vagina ... insert in the umbilicus and that's where we end up inside the patient's abdomen, which is…I ...

371

Amniocentesis  

Medline Plus

Full Text Available ... any of the following symptoms. • Moderate to severe abdominal pain or cramping • Chills or a fever higher than 100 °F or 38 °C • Dizziness • Bleeding or fluid leakage from your vagina or from ...

372

Locally aggressive colonic and rectal cancer ,clinical trial  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This clinical trial studies local invasions from primary colonic and rectal cancers (urinary bladder, abdominal wall, small bowls, uterus, vagina, stomach, bile tract, spleen, duodenum, pancreas, ureters, kidneys), with or without undiscovered metastasis.

Radu, V.; Ion, D.; S?erban, Mb; Ciurea, M.

2010-01-01

373

Robotic-Assisted Laparoscopic Sacrocolpopexy for Vaginal Vault Prolapse  

Medline Plus

Full Text Available ... resupporting the vagina to the sacrum using a polypropylene mesh. Dr. Jennifer Wu, Assistant Professor of Obstetrics ... mesh, I would use, personally, a wide-weave polypropylene. I wouldn't use Gore-tex mesh. It's ...

374

Ovarian Cancer  

Medline Plus

Full Text Available Ovarian Cancer Introduction Ovarian cancer is fairly rare. Ovarian cancer usually occurs in women who are over 50 years ... located above and behind the vagina and uterus. Cancer and its Causes The body is made up ...

375

Intraperitoneal leech: A rare complication of leech bite  

Digital Repository Infrastructure Vision for European Research (DRIVER)

An intraperitoneal leech, which entered through vagina and uterus in a 2-year-old girl is reported. The child presented with intraperitoneal hemorrhage and shock. A leech inside the peritoneal cavity has never been reported in the literature.

Saha, Manoj; Nagi, Sedengulie

2011-01-01

376

Review of Vaginitis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Adisruption of the dynamic equilibrium of the healthy vagina may have significant sequelae, leading to chronic or serious conditions. Therefore, all cases of vaginitis should be accurately diagnosed and appropriately treated.

Faro, Sebastian

1993-01-01

377

Sexually Transmitted Diseases  

Medline Plus

Full Text Available ... painless bumps in the vaginal area, on the penis, or around the anus. If untreated, the warts ... of gonorrhea are: • Discharge from the vagina or penis This document is for informational purposes and is ...

378

Vaginal Infections  

Science.gov (United States)

... avoid vaginal infections Abnormal discharge top You may wonder if the fluid, or discharge, that comes out ... like wet places, too! Don’t douche. Putting water or other products into your vagina removes some ...

379

Female Reproductive System  

Science.gov (United States)

Ever wonder how the universe could allow the existence of someone as annoying as your bratty little brother or ... comes out through the vagina when the mother's water breaks. When the contractions of labor begin, the ...

380

Vaginal Birth  

Medline Plus

Full Text Available ... blood through the placenta. Lightening The baby’s blood travels to the placenta through the umbilical cord. The ... vagina and comes out! The path the baby travels through is called the birth canal. After the ...

 
 
 
 
381

Bleeding during Pregnancy  

Science.gov (United States)

... The tissue may be removed by dilation and curettage (D&C) . It also may be removed by ... uterus, which protrudes into the vagina. Dilation and Curettage (D&C): A procedure in which the cervix ...

382

Intestinal Infarctus following Dilatation and Uterine Curettage  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We present a case of intestinal infarctus through the vagina. This was a consequence of induced abortion done clandestinely. The main objective was to point out the surgical complications of uterine dilatation and curettage by means of this rare case.

Ngowe, N. M.; Atangana, R.; Eyenga, V. C.; Sosso, M. A.

2008-01-01

383

HPV Vaccine Information for Young Women  

Science.gov (United States)

... in women and other less common cancers— like cancers of the anus, penis, vagina, and vulva and oropharynx (back of throat including base of tongue and tonsils). Other types of HPV can cause warts in ...

384

Robot-Assisted Gynecologic Surgery  

Medline Plus

Full Text Available ... that balloon we see below there? That’s a foley catheter balloon placed in the vagina. If we ... after the surgery, the catheter comes out, the foley catheter comes out. They’re up walking around, ...

385

Menopause  

Medline Plus

Full Text Available ... the vagina during the menstrual period. The menstrual cycle is usually 28 days. The levels of estrogen ... of the many hormones that control the menstrual cycle. In addition to regulating the menstrual cycle, estrogen ...

386

Robotic-Assisted Laparoscopic Sacrocolpopexy for Vaginal Vault Prolapse  

Medline Plus

Full Text Available ... the vagina to the sacrum using a polypropylene mesh. Dr. Jennifer Wu, Assistant Professor of Obstetrics and ... was very clear that she had not had mesh. However, when we got in we found that ...

387

Hysterectomy  

Science.gov (United States)

... want children, hysterectomy can cure problems from fibroids. Endometriosis (en-doh-mee-tree-OH-suhs). This health ... the vagina to hold the womb in place. Adenomyosis (uh-den-oh-my-OH-suhs). In this ...

388

Microflora of urogenital tract in pregnancy with asymptomatic bacterium  

International Nuclear Information System (INIS)

The article contains results of research interrelationship from colonization of vagina and urinary tract diseases. E.coli one of the main factors in development asymptomatic bacterium. Presented high effects of penicillin medicaments and nitrofurans in treatment of asymptomatic bacterium

2006-01-01

389

Systems Approach to Vaginal Delivery of Contraceptive Drugs--Methodology and Mechanism for Absorption.  

Science.gov (United States)

Technology was first developed for perfusing the vaginas of rabbits to determine membrane resistance to absorption. A homologous series of n-alkanols were used as model compounds to establish the method. Subsequently the technique was extended to rhesus m...

W. I. Higuchi

1978-01-01

390

Bladder Cancer  

Science.gov (United States)

... Macroscopic perivesical fat invasion (and progressing beyond bladder) T4: Tumor invades prostate, uterus, vagina, pelvic wall or ... hour. Once the bladder has been assessed as free of disease at the first three month post- ...

391

Hysterectomy  

Medline Plus

Full Text Available ... organs include: • Vagina • Uterus • Fallopian tubes • And ovaries. These organs are located in the pelvis, between the ... of specialized hormones such as estrogen and progesterone. These hormones are very important in regulating the second ...

392

Uterine Fibroids  

Medline Plus

Full Text Available ... uterine fibroids and their causes, symptoms, diagnosis, and treatment options. Anatomy Vagina Uterus Fallopian Tubes Ovaries The female ... in shrinking the uterus and the fibroids. New treatment options have been developed to deal with fibroids. These ...

393

Menopause  

Medline Plus

Full Text Available ... In fact, heart disease kills more women than lung or breast cancer. The following tips will help ... heart attacks, strokes and blood clots in the lungs and legs. The Vagina Body tissue in the ...

394

32 CFR 199.4 - Basic program benefits.  

Science.gov (United States)

...i) Birth control (such as contraception) â(A) Benefits provided...Surgical sterilization (either male or female). (B) Exclusions...surgical sterilization procedure (male or female). (ii) Genetic...prolapsed vagina in a biological male who had undergone...

2010-07-01

395

Robotic-Assisted Laparoscopic Sacrocolpopexy for Vaginal Vault Prolapse  

Medline Plus

Full Text Available ... of the vasculature. Middle sacral vessels line the space as well as a number of venous plexuses, ... reasons. One would be difficulty dissecting the presacral space, difficulty suturing the mesh to the vagina and ...

396

Endometriosis  

Medline Plus

Full Text Available ... above and behind the vagina and uterus. The pituitary gland, which is located at the base of the brain, controls the ovaries. The pituitary gland secretes hormones called LH and FSH, which ...

397

Barrier methods of birth control - series (image)  

Science.gov (United States)

The sponge is inserted by the woman into the vagina and covers the cervix blocking sperm from entering the cervix. The sponge also contains a spermicide that kills sperm. It is available without a ...

398

Robotic-Assisted Hysterectomy  

Medline Plus

Full Text Available ... vagina from the cervix and uterus. 00:21:40 AMY KIRKPATRICK BROWN, MD, MPH: And I have ... laparoscopically could be performed with robotic assistance. 00:40:04 AMY KIRKPATRICK BROWN, MD, MPH: And you ...

399

Boron  

Science.gov (United States)

... and muscle coordination. Women sometimes use capsules containing boric acid, the most common form of boron, inside the vagina to treat yeast infections. People also apply boric acid to the skin as an astringent or to ...

400

Laparo-Endoscopic Single-Site (LESS) Procedure  

Medline Plus

Full Text Available ... with less operative time, less pain, great cosmetic results, and they don't have to receive the ... through the umbilicus; and we have such great results that having to go through the vagina or ...

 
 
 
 
401

Pelvic Organ Prolapse  

Medline Plus

Full Text Available ... urinary incontinence (involuntary loss of urine while coughing, sneezing, or laughing). Rectal prolapse into the vagina (rectocele) ... urinary incontinence (involuntary loss of urine while coughing, sneezing, or laughing). Small intestine prolapse (enterocele) The small ...

402

Vaginal Anomalies: Urogenital Sinus  

Science.gov (United States)

... sit amet, consectetur adipiscing elit. Vaginal Abnormalities: Urogenital Sinus The urethra and vagina are separate anatomical entities ... are joined in what urologists call a urogenital sinus anomaly. The following information can help you talk ...

403

Vaginal Birth  

Medline Plus

Full Text Available ... The vagina 2. The cervix 3. The uterus 4. The Fallopian tubes 5. The ovaries When an ... cervix is 10 centimeters wide. This is about 4 inches. This is when the mother may be ...

404

Get Tested for Cervical Cancer  

Science.gov (United States)

... uterus, ovaries, and other organs. What is cervical cancer? Cervical cancer is cancer of the cervix, which is ... womb) to the vagina. Learn more about cervical cancer and screening: Cervical Cancer [PDF - 897 KB] Cervical Cancer Screening Take ...

405

Robotic-Assisted Laparoscopic Sacrocolpopexy for Vaginal Vault Prolapse  

Medline Plus

Full Text Available ... or reattaching the vagina to the bladder, or am I completely off target?" And I think sometimes ... in the right hand. Yes. I use an AMS Y-mesh. I've already trimmed that. If ...

406

Laparoscopic Supracervical Hysterectomy  

Medline Plus

Full Text Available ... Cederlind will show you this later, that the support structures for the uterus and cervix come in ... if you leave the cervix in place, you support the top of the vagina better. And we ...

407

Abdominal Pain or Cramping  

Science.gov (United States)

... from your vagina Fever Chills Lightheadedness or faintness Ectopic pregnancy During the first 3 months of pregnancy, abdominal pain can be a sign of ectopic pregnancy. An ectopic pregnancy occurs when the fertilized egg ...

408

HPV Test  

Science.gov (United States)

... in males; however, some specialty labs have validated DNA tests for analyzing anal swabs from males. Test Preparation ... vagina, mouth, throat, penis, and anus. The HPV DNA test detects the genetic material of the high-risk ...

409

Robotic-Assisted Laparoscopic Sacrocolpopexy for Vaginal Vault Prolapse  

Medline Plus

Full Text Available ... a particular part in the vagina. We usually break it down by compartments, either the anterior compartment, ... what it is. I don't want to break the suture either at this point. Okay. And ...

410

Robotic-Assisted Hysterectomy  

Medline Plus

Full Text Available ... This incision in the vagina will be a full circle, and it will remove the cervix and ... support procedures robotically for these -- that's a nice picture -- for these problems as well. 00:30:44 ...

411

Robotic-Assisted Laparoscopic Sacrocolpopexy for Vaginal Vault Prolapse  

Medline Plus

Full Text Available ... could deviate the vagina anteriorly up towards the synthesis. Thanks very much. And I'm just going ... and cut it. I would just start a new suture, bring it to it, and then tie ...

412

Safer Sex Guidelines  

Science.gov (United States)

... from a woman’s vagina, before, during, or after orgasm. HIV can be transmitted when infected fluid gets ... they pull their penis out before they reach orgasm. This isn’t true, because HIV can be ...

413

Genital prolapse in women  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Prolapse of the uterus or vagina is usually the result of loss of pelvic support, and causes mainly non-specific symptoms. It may affect over half of women aged 50 to 59 years, but spontaneous regression may occur.

Onwude, Joseph Loze

2009-01-01

414

Pelvic Support Problems  

Science.gov (United States)

... the pelvic floor . Layers of connective tissue called fascia also provide support. These supporting muscles and fascia ... intestine into the upper part of the vagina. Fascia: Tissue that supports the organs and muscles of ...

415

HIV and AIDS  

Medline Plus

Full Text Available ... or vagina. Cryptococcal meningitis causes inflammation of the membranes and fluid around the brain and spinal cord. ... Pneumocystis carinii pneumonia, or PCP, attacks the lungs. This makes it difficult for the ...

416

C-Section  

Medline Plus

Full Text Available ... it is important to know about the female reproductive organs. They are located in the pelvis, between ... 2 3 4 4 5 5 The female reproductive organs include: 1. The vagina 2. The cervix ...

417

Posterior pelvic floor prolapse and a review of the anatomy, preoperative testing and surgical management.  

Science.gov (United States)

The vagina proper extends from the hymen to the cervix and uterus. The anterior wall of the rectum and the posterior vaginal wall are fused for approximately 3 to 4 cm into the vagina. Above this, a plane of dissection is easily created. Plastic repair of the posterior vagina that utilizes ''fascia'' are in fact using the split adventicia and fibromuscular walls of the vagina to support the anterior wall of the rectum. Evaluation of posterior vaginal wall defects requires not only an anatomical description of the prolapse, but also correlation of any functional derangements that may exist. Evaluation may include; defecography, bowel transit studies, manometry, endoluminal ultrasound and magnetic resonance imaging. Surgical correction of posterior vaginal wall prolapse includes vaginal, trans anal and abdominal approaches. Vaginal approaches include site specific repairs and traditional posterior colporrhaphy with levator ani placation. Graft augmentation has been described with both approaches in an effort to improve outcomes and decrease failure rates. PMID:18487967

Kleeman, S D; Karram, M

2008-04-01

418

Hysterectomy  

Medline Plus

Full Text Available ... front of the vagina and uterus. The kidneys drain the urine into the bladder through 2 specialized ... surgeon may also decide during the operation to drain After waking up, the patient is allowed to ...

419

Ovarian Cancer  

Medline Plus

Full Text Available ... front of the vagina and uterus. The kidneys drain the urine into the bladder through 2 tubes ... a clear fluid produced by the body that drains waste from cells. It travels through special vessels ...

420

Menopause  

Medline Plus

Full Text Available ... Last reviewed: 03/12/2012 1 Anatomy The female reproductive organs include the: • vagina • uterus • fallopian tubes • ovaries The female reproductive organs are located in the pelvis, between ...

 
 
 
 
421

38 CFR Appendix C to Part 4 - Alphabetical Index of Disabilities  

Science.gov (United States)

... And both ovaries, removal7617 Disease or injury7613 Displacement7622 Prolapse7621 Removal7618 Uveitis6000 Vagina, disease or injury7611 Vagotomy7348 Valvular heart disease7000 Varicose veins7120...

2009-07-01

422

Menopause  

Medline Plus

Full Text Available ... and the vagina during the menstrual period. The menstrual cycle is usually 28 days. The levels of estrogen ... 2 of the many hormones that control the menstrual cycle. In addition to regulating the menstrual cycle, estrogen ...

423

Vaginal Birth  

Medline Plus

Full Text Available ... needle through the vagina to numb the pudendal nerve. This relieves some pain and the mother can ... and cesarean sections. Medication is delivered to the nerves of the spine in the lower back. An ...

424

Ambiguous genitalia  

Science.gov (United States)

... well as a uterus, vagina, and fallopian tubes. Congenital adrenal hyperplasia . This condition has several forms, but the most ... trouble breathing These can all be signs of congenital adrenal hyperplasia . Ambiguous genitalia may be discovered during the first ...

425

Mice immunized by primary vaginal Candida albicans infection develop acquired vaginal mucosal immunity.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

It has been postulated that systemic cell-mediated immunity (CMI) is an important host defense mechanism against Candida infections of the vagina. However, in an estrogen-dependent murine model of experimental vaginal candidiasis, we recently showed that systemic Candida-specific Th1-type CMI induced by immunization with Candida culture filtrate antigen had no effect on vaginal Candida population levels during the course of a vaginal infection. In the present study, mice given a second vagina...

Fidel, P. L.; Lynch, M. E.; Conaway, D. H.; Tait, L.; Sobel, J. D.

1995-01-01

426

Mayer-Rokitansky-Kuster-Hauser Syndrome: Surgical Management of Two Cases  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Mayer-Rokitansky-Kuster-Hauser (MRKH) Syndrome is a rare anomaly characterized by congenital aplasia of the uterus and vagina in women showing normal development of secondary sexual characters and normal 44 XX karyotype. We report our experience in the management of two patients with congenital absence of the vagina due to the MRKH syndrome. The first case was a 24-year-old student, who presented with primary amenorrhea, uterovaginal agenesis, right pelvi-ureteric junction obstruction, an...

Mungadi, I. A.; Ahmad, Y.; Yunusa, G. H.; Agwu, N. P.; Ismail, S.

2010-01-01

427

Histología uretral y vaginal en algunas hembras de mamíferos / Urethral and vaginal histology in some female mammals  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish El análisis de las características histológicas de la uretra y la vagina en hembras de mamíferos es útil para entender la fisiología y la patología de procesos como la continencia urinaria, la cópula y el parto. En este contexto, las especies más estudiadas en cuanto a la organización tisular de la [...] uretra y vagina son la rata y la coneja. Es necesario estudiar con más detalle la organización tisular de la vagina y uretra en diferentes especies con fines de comparación. Tal información permitiría entender la diversidad funcional y conductual asociada a estos órganos. El presente documento reúne, compara y discute la información existente sobre las características histológicas de la uretra y la vagina en algunas hembras de mamíferos destacando aquellas de la coneja, modelo utilizado por nuestro grupo de investigación para estudiar la fisiología reproductiva y urinaria femenina. Abstract in english The analysis of the histological characteristics of the urethra and the vagina in female mammals is useful in understanding the physiology and pathology of processes such as urinary continence, copulation and delivery. In this regard, the species most studied with respect to the histological organis [...] ation of the urethra and vagina, are the rat and the rabbit. For comparative purposes, it is necessary to study in greater detail the histological organisation of the urethra and vagina in different species. The information gathered could help understand the functional and behavioural diversity associated with these organs. This study gathers, compares and discusses the existing information on the histological characteristics of the urethra and vagina in some mammal females, with emphasis on those of the rabbit, a model used by our research group to study female reproductive and urinary physiology.

Rodríguez-Antolín, J; Cuevas, E; Nicolás, L; Fajardo, V; Castelán, F; Martínez-Gómez, M.

428

Recent Advances in Understanding the Microbiology of the Female Reproductive Tract and the Causes of Premature Birth  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Data derived from molecular microbiological investigations of the human vagina have led to the discovery of resident bacterial communities that exhibit marked differences in terms of species composition. All undergo dynamic changes that are likely due to intrinsic host and behavioral factors. Similar types of bacteria have been found in both amniotic fluid and the vagina, suggesting a potential route of colonization. Given that not all of the species involved in intrauterine infections are re...

2010-01-01

429

Demonstration of vaginal colonization with GusA-expressing Lactobacillus jensenii following oral delivery in rhesus macaques  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The vaginal microbiome, which harbors beneficial Lactobacillus strains, is believed to be a major host defense mechanism for preventing infections of the urogenital tract. It has been suggested that the gastrointestinal tract serves as a reservoir for lactobacilli that colonize the vagina. Using rhesus macaques, we examined whether oral delivery of human vaginal Lactobacillus jensenii-1153-1646, a GusA-producing strain, would result in colonization of the rectum and the vagina. Lactobacilli w...

2011-01-01

430

Anatomy of adult female common marmoset (Callithrix jacchus) reproductive system.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Better appreciation of the female reproductive anatomy of the common marmoset (Callithrix jacchus) should improve the prospects for nonsurgical embryo transfer in this model. Vaginal measurements were performed in 8 female adult marmoset monkeys. Four monkeys were measured at laparotomy for gross internal anatomy, and 1 monkey was analysed at autopsy. The vagina of the marmoset monkey was found to be divided into a lower and upper vagina with a marked vaginal isthmus between them. The mean le...

Cui, K. H.; Matthews, C. D.

1994-01-01

431

Pregnancy following re-stenosis of complete transverse vaginal septum  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We report a case of 23 year woman who came to us with 6 weeks pregnancy and complete transverse vaginal septum. Cesarean section along with resection of septum was done. Restenosis of vagina was observed during puerperium. No surgical intervention was done. Spontaneous pregnancy with well- formed vagina was noted after 3 years. [Int J Reprod Contracept Obstet Gynecol 2013; 2(2.000): 229-230

Alka Sehgal; Shikha Rani; Navneet Takkar

2013-01-01

432

Influence of Calotropis procera roots on biochemistry of reproductive organs of ovariectomized rats  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Biochemical alterations have been observed in the uterus, cervix and vagina of ovariectomized rats treated with alcoholic extract of Calotropis procera roots administered in the presence and absence of ethynilestradiol. Ovariectomy resulted in the decrease of glycogen and protein content as well as activity of acid and alkaline phosphatase in the uterus, cervix and vagina. Administration of the alcoholic extract of Calotropis procera increases glycogen and protein content an...

Ahirwar D; Ahirwar Bharti; Kharya M

2007-01-01

433

Magnetic resonance imaging of vaginal and vulval pathology  

Energy Technology Data Exchange (ETDEWEB)

There are a number of conditions affecting the vagina and vulva that can be optimally assessed with the use of high-resolution magnetic resonance imaging (MRI). This paper gives a suggested protocol for MRI technique and sequences for imaging the pelvis and perineum and reviews the MRI appearances of many of the common pathologies affecting the vagina and vulva. Congenital anomalies, inflammatory and neoplastic entities such as vaginal and vulval carcinoma are discussed, with rarer malignancies also reviewed. (orig.)

Griffin, N.; Grant, L.A.; Sala, E. [Addenbrooke' s Hospital, Department of Radiology, Box 219, Cambridge (United Kingdom)

2008-06-15

434

Vesicovaginal reflux: A case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Vesicovaginal reflux is a common cause of urinary incontinence in girls. A micturating cystourethrogram, which is the diagnostic investigation of choice, can demonstrate retrograde filling of the vagina during micturition and the complete emptying of the vagina at the end of micturition. Vesicovaginal reflux is a rare cause of gross hydrocolpos occurring without any anatomical obstruction. The condition may be associated with functional voiding disturbances.

Warade, Monali; Majid, Yameen; Dayananda, L.; Gupta, Kanchan

2009-01-01

435

Study on Two Inoculation Routs of Salmonella enteritidis in Abilities to Colonize in Internal Organs and to Contaminate of Eggs in Broiler Breeder Hens  

Directory of Open Access Journals (Sweden)

Full Text Available Two groups of chickens were inoculated orally and intravenously with 1010 and 106 CFU S. enteritidis organisms consequently. Heavier infection of liver spleen, caecum, small intestines, infundibulum-ovules and cloac-vagina of chickens that inoculated orally were observed. In intravenously inoculated group high infection of liver-spleen and cloac- vagina were noticed. In oral group egg production were more decreased and fecal shedding was higher than intravenously group.

A. Yazdani

2010-01-01

436

Pregnancy following re-stenosis of complete transverse vaginal septum  

Directory of Open Access Journals (Sweden)

Full Text Available We report a case of 23 year woman who came to us with 6 weeks pregnancy and complete transverse vaginal septum. Cesarean section along with resection of septum was done. Restenosis of vagina was observed during puerperium. No surgical intervention was done. Spontaneous pregnancy with well- formed vagina was noted after 3 years. [Int J Reprod Contracept Obstet Gynecol 2013; 2(2.000: 229-230

Alka Sehgal

2013-04-01

437

Escherichia coli Strains from Pregnant Women and Neonates: Intraspecies Genetic Distribution and Prevalence of Virulence Factors  

Digital Repository Infrastructure Vision for European Research (DRIVER)

To determine the extent to which the vagina, endocervix, and amniotic fluid screen the Escherichia coli strains responsible for neonatal infections, we studied the genetic relationships among 105 E. coli strains isolated from all of the ecosystems involved in this infectious process. Twenty-four strains were isolated from the intestinal flora, and 25 strains were isolated from the vaginas of pregnant women. Twenty-seven strains were isolated from the amniotic fluid, blood, and cerebrospinal f...

Watt, Ste?phane; Lanotte, Philippe; Mereghetti, Laurent; Moulin-schouleur, Maryvonne; Picard, Bertrand; Quentin, Roland

2003-01-01

438

Reconstructive surgical management of cryptomenorrhoea because of complete vaginal agenesis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background: The Vagina is a composite structure formed partly from the mullerian duct and partly from urogential sinus. Most of the patients with mullerian agenesis have small rudimentary uterus without any endometrial cavity, 7% - 8% may have functioning uterus. Case: A 15 years old girl admitted with primary amenorrhea, cyclical abdominal pain, hematometra and complete vaginal agenesis. Surgical correction is the mainstay of treatment in patients with functioning uterus and absent vagina. V...

Krishna Dahiya; Ranjita Bains

2011-01-01

439

In Vitro Activity of Nifuratel on Vaginal Bacteria: Could It Be a Good Candidate for the Treatment of Bacterial Vaginosis??  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Bacterial vaginosis is characterized by a shift of the physiological flora to a diverse spectrum of bacteria, where Gardnerella vaginalis and Atopobium vaginae are the most important markers. In this study, the antimicrobial activity of nifuratel against G. vaginalis, A. vaginae, and lactobacilli was compared with that of the two currently used antibiotics metronidazole and clindamycin. Results suggest that nifuratel has a better spectrum of activity, being highly active against G. vaginalis ...

Togni, Giuseppe; Battini, Valeria; Bulgheroni, Anna; Mailland, Federico; Caserini, Maurizio; Mendling, Werner

2011-01-01

440

[Surgical management of congenital high vaginal atresia].  

Science.gov (United States)

In the past 15 years five neonates and children have been treated for high vaginal atresia at the Surgical Unit of Department of Pediatrics, University Medical School, Pécs, Hungary. In three of the six patients distal atresia of the vagina was found (Type III). Two of the three were neonates and had a large hydrometrocolpos and the third, a 13-year-old girl, hematometrocolpos. In the fourth patient the vaginal atresia was associated with cloacal and anorectal malformation (Type V). In the fifth there was a duplication of uterus and vagina; however, only one of the two vaginas was atretic. In three patients a pull-through of the vagina was carried out, in one of them according to Pena, in another a transvesical approach, as suggested by Monfort, was used. Following repeated surgeries in the patient with cloacal malformation the vagina was replaced with large intestine. In the case of duplication of vagina and uterus one half of the duplication was removed. PMID:8464627

Alchihabi, N; Pintér, A

1993-04-01

 
 
 
 
441

Recent Advances in Understanding the Microbiology of the Female Reproductive Tract and the Causes of Premature Birth  

Science.gov (United States)

Data derived from molecular microbiological investigations of the human vagina have led to the discovery of resident bacterial communities that exhibit marked differences in terms of species composition. All undergo dynamic changes that are likely due to intrinsic host and behavioral factors. Similar types of bacteria have been found in both amniotic fluid and the vagina, suggesting a potential route of colonization. Given that not all of the species involved in intrauterine infections are readily cultivated, it is important that culture-independent methods of analysis must be used to understand the etiology of these infections. Further research is needed to establish whether an ascending pathway from the vagina to the amniotic cavity enables the development of intrauterine infections.

Zhou, Xia; Brotman, Rebecca M.; Gajer, Pawel; Abdo, Zaid; Schuette, Ursel; Ma, Sam; Ravel, Jacques; Forney, Larry J.

2010-01-01

442

Anatomia e histologia do conduto genital feminino de Pomacea canaliculata (Lamarck, 1822 (Mollusca, Gastropoda, Pilidae  

Directory of Open Access Journals (Sweden)

Full Text Available In this paper the authors give an anatomical and histological analysis of the genital duct in mature and immature females of Pomacea canaliculata (Lamarck, 1822. Anatomically, the vagina has an equal dimension in its extension, varying in form and volume, according to the maturation period. In the immaturity, it has a smaller diameter and volume. In the maturity, the vagina increases in volume, having the aspect of a tumescent organ, and in certain specimens shows an albuminous pink thread in its lumen. Histologically, the calcigenic activity of the gland is evidentiated by the presence of an amorphous and basophilic mass, without nuclear material. This material has a fragmented aspect in the vagina lumen that reacts positively in van Kossa's coloured preparations for calcareous salts.

Eliana de Fátima Marques de Mesquita

1990-01-01

443

Sobre uma nova espécie do gênero Acanthocolpus Lühe, 1906 On a new specie under Acanthocolpus Lühe, 1906  

Directory of Open Access Journals (Sweden)

Full Text Available Os autores, na presente nota, propõem Acanthocolpus brasiliensis sp. n. sendo este gênero pela primeira vez referido no Brasil. A espécie aqui descrita difere das demais do gênero pela ausência de espinhos na vagina e no ducto hermafrodita e pela presença de vitelinos em quase toda extensão da metade posterior do corpo.In this paper the authors propose a new specie under Acanthocolpus Lühe, 1906 also reafirms this genus for the first time in Brasil. Acanthocolpus brasiliensis sp. n. differs from the other species of the genus by presenting folicular vitellaria in almost the hole area of the posterior part of the body, by the absence of spines in vagina and in ejaculatory duct. A. brasiliensis sp. n. is similar to A. orientalis Srivastava, 1939, which differs also by the size of the body, cirrus sac and vagina.

Berenice M. M. Fernandes

1973-01-01

444

Influence of Calotropis procera roots on biochemistry of reproductive organs of ovariectomized rats  

Directory of Open Access Journals (Sweden)

Full Text Available Biochemical alterations have been observed in the uterus, cervix and vagina of ovariectomized rats treated with alcoholic extract of Calotropis procera roots administered in the presence and absence of ethynilestradiol. Ovariectomy resulted in the decrease of glycogen and protein content as well as activity of acid and alkaline phosphatase in the uterus, cervix and vagina. Administration of the alcoholic extract of Calotropis procera increases glycogen and protein content and activity of acid and alkaline phosphatase in uterus and cervix with increasing weights, whereas, the glycogen contents decreased significantly in vagina. Combined treatments of the alcoholic extract with ethynilestradiol act synergistically confirm the estrogenic action of alcoholic extract of Calotropis procera roots in adult ovariectomized rats.

Ahirwar D

2007-01-01

445

Colovaginal anastomosis: an unusual complication of stapler use in restorative procedure after Hartmann operation  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Rectovaginal fistula is uncommon after lower anterior resection for rectal cancer. The most leading cause of this complication is involvement of the posterior wall of the vagina into the staple line when firing the circular stapler. Case presentation A 50-year-old women underwent resection for obstructed carcinoma of the sigmoid colon with Hartmann procedure. Four months later she underwent restorative surgery with circular stapler. Following which she developed rectovaginal fistula. A transvaginal repair was performed but stool passing from vagina not per rectum. Laporotomy revealed colovaginal anastomosis, which was corrected accordingly. Patient had an uneventful recovery. Conclusion Inadvertent formation of colovaginal anastomosis associated with a rectovaginal fistula is a rare complication caused by the operator's error. The present case again highlights the importance of ensuring that the posterior wall of vagina is away from the staple line.

Liao Guoqing

2005-11-01