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1

DNA fragmentation following chemotherapy and radiotherapy for uterine cervical carcinoma  

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The present study evaluated the effects of chemotherapy and radiotherapy in uterine cervical carcinoma cells using to measure DNA fragmentation as an indicator of apoptosis. We studied 11 Japanese women with uterine cervical carcinoma (aged 38 to 64 years), in which 6 patients consented to receive an injection of CBDCA (carboplatin) (150 mg) into the uterine artery during radical hysterectomy with pelvic lymphadenectomy and 5 others received radiotherapy. The DNA fragmentation was measured using the nick end-labeling method of paraffin sections from formalin fixed tissues obtained by biopsy before and after the hysterectomy. DNA fragmentation specific for apoptosis was found in tissue sections after the intraarterial injection of CBDCA as well as radiotherapy. The positive nuclei before and after injection of CBDCA was 2.37{+-}0.89% and 6.49{+-}1.79%, respectively. The number of positive nuclei after treatment varied between patients. The positive nuclei observed in 5 patients received radiotherapy was 4.95{+-}2.24% before radiotherapy, 13.85{+-}5.79% after 10 Gy, 10.59{+-}5.51% after 30 Gy and 1.37{+-}1.04% after 50 Gy. The highest proportion of positive nuclei was seen at doses of 10 Gy and 30 Gy. Apoptosis was thought to be the principal cause of the cell death resulting from chemotherapy and radiotherapy in uterine cervical carcinoma, and to be induced several hours after the intra-arterial injection of CBDCA or during radiotherapy with low doses. (K.H.)

Murakami, Junko; Nagai, Nobutaka; Ohama, Koso [Hiroshima Univ. (Japan). School of Medicine

1997-12-01

2

Perceptions of women concerning preventive examination of uterine cervical câncer  

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Full Text Available Objective: To understand the perception of women that will undergo the preventive examinationof uterine cervical cancer. Methods: It was an exploratory-descriptive study. The sample was comprised by 25 women in the age group from 18 to 59 years, users of the Mother-Child Health Center in Barbalha-CE-Brazil. Data collection happened between May and June 2009 using semi-structured interviews with the following guiding questions: What do you know about the purpose of the preventive examination of uterine cervical cancer? What made you seek the health unit to perform this examination? What do you feel when you undergo the examination? Data were analyzed based on the subjects’ speeches categorization, and later discussed according to the literature concerning the subject. Results: The investigation showed that the subjects understand the preventive examination with a healing perspective, since most seek the service facing some symptoms; shame and fear are the main expressed feelings concerning the examination. These factors can contribute to the non adherence to Pap test. Conclusion: The women interviewed showed to have superficial and often wrong knowledge on the examination of cervical cancer. This reveals the need for re-orientation of health services focusing on health promotion, providing the users knowledge and awareness to act as jointly responsible for their health, by adhering to the examination and probably reducing the number of cases of uterine cervical cancer.

Mirna Neyara Alexandre de Sá Barreto Marinho

2010-06-01

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Preoperative uterine artery embolization and evacuation in the management of cervical pregnancy: report of two cases.  

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Preoperative uterine artery embolization and cervical evacuation as conservative management of cervical pregnancy has been tried in recent years. However, cervical suturing, vasoconstrictor injection, or cervical ballooning was frequently used as an ancillary measures in those procedures in most of the previous studies. We report two cases of cervical pregnancy that were successfully treated with preoperative uterine artery embolization and removal of gestational material without ancillary pr...

Ryu, K. Y.; Kim, S. R.; Cho, S. H.; Song, S. Y.

2001-01-01

4

Pharmacokinetics of adriamycin vaginal suppository on uterine cervical cancer  

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Vaginal suppositories of Adriamycin (ADM, 5 mg), for reducing the capacity for repair from sublethal damage of X-ray-irradiated cells, were prepared using Wipepsol S-55 as the vehicle, and were intravaginally administered to patients with advanced uterine cervical cancer, and their pharmacokinetics and clinical effects were studied. The ADM concentration in the uterine cervical cancer tissues indicated high levels (17 to 566 ?g/g), and migration into the cardinal ligament and regional lymph nodes was noted. However, little ADM was detected in serum (0 to 0.14 ?g/g), probably because of its molecular weight and excellent tissue absorbance, and no side effects, such as cardiotoxicity and myelosuppression due to consecutive administration were detected. Histologically, the effect obtained when administered alone was limited, administration in combination with radiotherapy being more effective. Accordingly, radiotherapy of advanced uterine cervical cancer with concomitant administration of ADM vaginal suppositories seems to bring about a more powerful antitumoral effect with fewer systemic side effects. (author)

5

Superselective intraarterial chemotherapy into bilateral uterine arteries in uterine cervical carcinomas  

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To assess the efficacy of superselective intra-arterial chemotherapy(SSIAC) via the bilateral uterine arteries in cases of cervical carcinoma. Eighteen patients with stage 2 {sub a}(n=10), 2 {sub b}(n=7), or 3 {sub a}(n=1) cervical carcinoma underwent one(n=2) or two(n=16) courses of preoperative SSIAC with Vincristine, Cisplatin, and Mitomycin C. We estimated the extent of reduction of tumor volume and improvement of stage, comparing pre-SSIAC MRI to postoperative results. Tumor vascularity, as seen on uterine arteriography, and procedural complications, were also evaluated. A marked reduction in tumor volume was observed in all patients, an average reduction volume of 94.7%. Improvement of stage was noted in 16 patients, and in six of these, no residual viable tumor or microinvasive residual tumor was seen. On angiography, tumor hypervascularity was demonstrated in seven patients, but its degree was not substantially related to therapeutic response. In no case did significant systemic complications of result from chemotherapy; in one patient, however, we experienced a serious complication of necrotizing cystitis due to malpositioning of a catheter in the superior vesical artery. SSIAC via the bilateral uterine arteries is an effective complementary modality for the treatment of various stages of cervical carcinoma.

Jang, Hyun Jung; Choi, Guk Myeong; Park, Sun Won; Kim, Tae Kyoung; Chung, Jin Wook; Park, Jae Hyung [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

1997-10-01

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Superselective intraarterial chemotherapy into bilateral uterine arteries in uterine cervical carcinomas  

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To assess the efficacy of superselective intra-arterial chemotherapy(SSIAC) via the bilateral uterine arteries in cases of cervical carcinoma. Eighteen patients with stage 2 a(n=10), 2 b(n=7), or 3 a(n=1) cervical carcinoma underwent one(n=2) or two(n=16) courses of preoperative SSIAC with Vincristine, Cisplatin, and Mitomycin C. We estimated the extent of reduction of tumor volume and improvement of stage, comparing pre-SSIAC MRI to postoperative results. Tumor vascularity, as seen on uterine arteriography, and procedural complications, were also evaluated. A marked reduction in tumor volume was observed in all patients, an average reduction volume of 94.7%. Improvement of stage was noted in 16 patients, and in six of these, no residual viable tumor or microinvasive residual tumor was seen. On angiography, tumor hypervascularity was demonstrated in seven patients, but its degree was not substantially related to therapeutic response. In no case did significant systemic complications of result from chemotherapy; in one patient, however, we experienced a serious complication of necrotizing cystitis due to malpositioning of a catheter in the superior vesical artery. SSIAC via the bilateral uterine arteries is an effective complementary modality for the treatment of various stages of cervical carcinoma

7

Short-course palliative radiotherapy for uterine cervical cancer  

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The purpose of this retrospective study was to evaluate the efficacy and feasibility of short-course hypofractionated radiotherapy (RT) for the palliation of uterine cervical cancer. Seventeen patients with cancer of the uterine cervix, who underwent palliative hypofractionated 3-dimensional conformal radiotherapy between January 2002 and June 2012, were retrospectively analyzed. RT was delivered to symptomatic lesions (both the primary mass and/or metastatic regional lymph nodes). The total dose was 20 to 25 Gy (median, 25 Gy) in 5 Gy daily fractions. The median follow-up duration was 12.2 months (range, 4 to 24 months). The median survival time was 7.8 months (range, 4 to 24 months). Vaginal bleeding was the most common presenting symptom followed by pelvic pain (9 patients). The overall response rates were 93.8% and 66.7% for vaginal bleeding control and pelvic pain, respectively. Nine patients did not have any acute side effects and 7 patients showed minor gastrointestinal toxicity. Only 1 patient had grade 3 diarrhea 1 week after completion of treatment, which was successfully treated conservatively. Late complications occurred in 4 patients; however, none of these were of grade 3 or higher severity. Short-course hypofractionated RT was effective and well tolerated as palliative treatment for uterine cervical cancer.

Kim, Dong Hyun; Lee, Ju Hye; Ki, Yong Kan; Kim, Won Taek; Park, Dahl; Kim, Dong Won [Dept. of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital, Busan (Korea, Republic of); Nam, Ji Ho; Jeon, Sang Ho [Dept. of Radiation Oncology, Pusan National University Yangsan Hospital, Yangsan (Korea, Republic of)

2013-12-15

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Short-course palliative radiotherapy for uterine cervical cancer  

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The purpose of this retrospective study was to evaluate the efficacy and feasibility of short-course hypofractionated radiotherapy (RT) for the palliation of uterine cervical cancer. Seventeen patients with cancer of the uterine cervix, who underwent palliative hypofractionated 3-dimensional conformal radiotherapy between January 2002 and June 2012, were retrospectively analyzed. RT was delivered to symptomatic lesions (both the primary mass and/or metastatic regional lymph nodes). The total dose was 20 to 25 Gy (median, 25 Gy) in 5 Gy daily fractions. The median follow-up duration was 12.2 months (range, 4 to 24 months). The median survival time was 7.8 months (range, 4 to 24 months). Vaginal bleeding was the most common presenting symptom followed by pelvic pain (9 patients). The overall response rates were 93.8% and 66.7% for vaginal bleeding control and pelvic pain, respectively. Nine patients did not have any acute side effects and 7 patients showed minor gastrointestinal toxicity. Only 1 patient had grade 3 diarrhea 1 week after completion of treatment, which was successfully treated conservatively. Late complications occurred in 4 patients; however, none of these were of grade 3 or higher severity. Short-course hypofractionated RT was effective and well tolerated as palliative treatment for uterine cervical cancer.

9

Late intestinal adverse effects of radiotherapy for uterine cervical cancer  

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We investigated the incidence and clinical appearance of late adverse intestinal effects in 88 patients treated with postoperative radiotherapy and 46 patients treated with radiotherapy alone for uterine cervical cancer. In the postoperative radiotherapy group, colitis, ileus and bowel fistules were seen in 13 patients (14.8%), 8 (9.1%), and 3 (3.4%) of the patients, respectively. Of these patients, 11 (12.5%) needed to have surgical therapy for these adverse effects. In the radiation alone group, 18 patients (39.1%) had colitis and 2 (4.3%) had ileus; of them, 2 patients (4.3%) needed to have surgical therapy. The higher incidence of so severe adverse effects as to require surgical therapy in the postoperative radiotherapy group indicates that adhesion caused by operation might have caused the occurrence of these adverse effects. Four of a total of 134 patients died of causes which might be attributable to irradiation. In 61 patients treated by radical hysterectomy without postoperative radiotherapy, intestinal adverse effects were not found. These results indicate that late intestinal adverse effects after radiotherapy are likely to occur in some cases very severely; therefore, careful consideration is necessary in the decision to use radiotherpay for uterine cervical cancer. (J.P.N.).

Tsukada, Seiji; Yamamoto, Yasuaki; Kaneko, Toru; Maruhashi, Toshihiro; Takahashi, Takeshi (Niigata Cancer Center Hospital (Japan))

1993-06-01

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What is better: cryocautery or electrocautery for cervical erosion?  

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Full Text Available Background: Present study was conducted with a background in mind to compare the efficacy of electrocautery and cryocautery for the management of cervical erosion. Aim of this study was to compare the efficacy of electrocautery and cryocautery for the treatment of cervical erosion and to check cost effectiveness. Methods: A comparative study was conducted at Maharishi Markandeshwar medical college and hospital, Kumarhatti (Solan between July'13 to June'14 among 100 patients of reproductive age group with cervical erosion. They were grouped into 2 groups A (Electrocautery and B (Cryocautery and data obtained was analysed by paired t-test. Results: Though in short- term follow-up at 4-6 weeks after cautery, apparently electrocautery was superior to cryocautery in terms of erosion healing rate 92% vs. 76% as P value (0.4557 is not statistically significant, but in long-term follow-up at 12-14 weeks there was no significant difference in erosion healing but electrocautery was cost effective. Conclusions: Both types of cautery were equally good for treatment of cervical erosion in long-term follow-up. But electrocautery occupies less space and there is no chance of gas leakage in electrocautery, so electrocautery is more cost effective. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 715-719

Monika Jindal

2014-06-01

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EARLY POSTOPERATIVE OUTCOMES IN PATIENTS WITH UTERINE CERVICAL CANCER  

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Full Text Available BACKGROUND: Uterine cervical cancer still presents high percentages of locally advanced tumors on diagnosis due to the lack of screening programs. The multidisciplinary approach in these cases requires neoadjuvant radio-chemotherapy followed in selected cases by surgery. The aim of this study was the assessment of early postoperative outcomes in a consecutive series of cervical cancer patients. METHODS: We performed a comparative analysis in terms of patients and tumor characteristics, type of surgery and postoperative complications on 83 patients with radical surgery divided in terms of neoadjuvant treatment protocol. Two groups were designed: group A, patients who underwent neoadjuvant therapy (n=38; 45.78% and group B, patients operated without neoadjuvant therapy (n=45; 54.22%. RESULTS: The patients mean age was 54.1±11.6 years old. Most cases on diagnosis were stage IIB (41 cases, 49.39% followed by stage IB (24 cases, 28.9%. Neoadjuvant treatment was performed in 38 patients (45.78% (stage IIA – 1 patient, IIB – 31 patients, IIIA – 1 patient and IIIB – 5 patients, with a complete response in 16 (42.1%. Most common intervention was type II radical hysterectomy with pelvic lymphadenectomy in 54 cases (65%. There was no difference in terms of deep vein thrombosis, postoperative urinary and medical morbidity. Digestive complications were relatively higher in neoadjuvant group (28.94% in group A vs. 6.66% in group B, P=0.008 with a longer hospitalization (8.1±2.7 days for group A vs. 6.6±1.6 for group B, P=0.01. CONCLUSION: Radical hysterectomy is a relatively safe technique in terms of postoperative morbidity for patients with cervical cancer despite the use of neoadjuvant therapy. This provides the chance for cure in early stages and a local control for more advanced cases.

M?d?lina Gavrilescu

2013-09-01

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KAMPILLAKADI GHRITA IN GARBHASHAYA GREEVA GATA VRANA (CERVICAL EROSION  

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Full Text Available Certain diseases may not be life threatening but troublesome and irritating to an individual in day to day routine activity. “Cervical erosion” is one among them increasing day by day and demanding greater concern over it. It is a benign condition but if left untreated may leads up to infertility and predisposes to cervical malignancy. Cauterization is the known treatment for cervical erosion but chances of recurrence of the disease are high. Keeping this fact in mind the present clinical study has been undertaken. The total effect of drug was evaluated on the basis of signs and symptoms after completion of therapy. The data obtained in clinical study before and after treatment was expressed in terms of Mean, Standard Deviation (+SD and Standard Error (+SE. Group-I revealed better results than Group-II over total criteria of assessment.

Dhiman Kamini

2012-04-01

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Is excretory urography necessary in the staging work-up of uterine cervical carcinoma?  

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Excretory urography has been routinely included in the staging work-up of uterine cervical carcinoma in the ear of popular use of computerized tomography (CT). The purpose of this retrospective study was to evaluate the necessity of excretory urography in the staging of uterine cervical carcinoma in addition to the routine CT. In 143 patients with histologically proven uterine cervical carcinoma, we compared excretory urography with CT, in respect to the ability of each study to demonstrated the pelvocalyces and the ureters, the level and the cause of the ureteral obstruction, and the invasion of urinary bladder. The results were as follows: Pelvocalyces and proximal ureters were demonstrated in 95% or more both on excretory urography and on CT, however, middle and distal ureters were demonstrated on CT better than on excretory urography. In 6 patients with ureteral obstruction by the extension of uterine cervical carcinoma, CT was more informative than excretory urography in respect to the level and the cause of the ureteral obstruction. CT was superior to excretory urography to confirm the presence or absence of the bladder invasion. From these results, we suggest that excretory urography can be omitted in the era of routine inclusion of CT in the staging work-up of uterine cervical carcinoma

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Fertility-sparing operation for recurrence of uterine cervical perivascular epithelioid cell tumor  

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Perivascular epithelioid cell tumors (PEComa) are mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelial cells. Although the uterine corpus seems to be one of the most prevalent sites of involvement, PEComa of the uterine cervix are very rare. Only four cervical PEComa cases have been described, and were treated with hysterectomy and radiotherapy. We report a case of a 24-year-old nulli­gravida woman who presented with acute abdominal pain...

Fumitaka Kikkawa; Akira Iwase; Sachiko Takigawa; Maiko Sakurai; Kazuhiko Ino; Eiko Yamamoto

2010-01-01

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Electron microscopic study on radiosensitivity of uterine cervical cancer  

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The effects of 1000 R of tele-cobalt upon the changes in the primary lesions of uterine cervical cancer with time were studied with an electron microscope. In addition, twenty cases which were proven to have cancer tissues (10 cases of IInd stage of cancer, 8 cases of IIIrd stage of cancer and 2 cases of IVth stage of cancer) were studied. Four cases were favourably sensitive, 7 cases moderately sensitive and 9 cases unfavourably sensitive to radiation. In favourably radio-sensitive cases, the changes in the cancer cells first appeared in the nucleus. There were other changes such as local clumping of chromatin and, specifically, vacuolization of the nucleus. The changes in the endoplasmic reticulum appeared somewhat late. In addition, the disturbance of mitochondria and the decrease or disappearance of ribosomes were specifically due to radiation injury. From the point of view of changes with time, Golgi's apparatus was enlarged and the membrane of the endoplasmic reticulum was degenerated at the 1st day. At the 3rd day, vacuolization of the nucleus appeared, the nuclear corpuscles were increased, the nucleoplasm became thin, and mitochondria was enlarged and degenerated. At the 5th day, the nuclear membrane disappeared, the nucleus was destroyed, large vacuolization of the endoplasmic reticulum was seen, free ribosomes were decreased, and changes around the endoplasmic reticulum were observed. At the 7th day, collagen around the endoplasmic reticulum appeared. In favourably radiosensitive cases, individual tumor cells showed the same degeneration, which fairly corresponded to that evaluated by the histological observation. The disturbance of the cells was caused by radiation, so-called ''burning'' of the cells. Radiation protection of the cells against burning was considered in terms of their radiosensitivity. (K. SERIZAWA)

16

Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology  

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To design clear guidelines for the staging and follow-up of patients with uterine cervical cancer, and to provide the radiologist with a framework for use in multidisciplinary conferences. Methods: Guidelines for uterine cervical cancer staging and follow-up were defined by the female imaging subcommittee of the ESUR (European Society of Urogenital Radiology) based on the expert consensus of imaging protocols of 11 leading institutions and a critical review of the literature. The results indicated that high field Magnetic Resonance Imaging (MRI) should include at least two T2-weighted sequences in sagittal, axial oblique or coronal oblique orientation (short and long axis of the uterine cervix) of the pelvic content. Axial T1-weighted sequence is useful to detect suspicious pelvic and abdominal lymph nodes, and images from symphysis to the left renal vein are required. The intravenous administration of Gadolinium-chelates is optional but is often required for small lesions (<2 cm) and for follow-up after treatment. Diffusion-weighted sequences are optional but are recommended to help evaluate lymph nodes and to detect a residual lesion after chemoradiotherapy. Expert consensus and literature review lead to an optimized MRI protocol to stage uterine cervical cancer. MRI is the imaging modality of choice for preoperative staging and follow-up in patients with uterine cervical cancer. (orig.)

17

Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology  

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To design clear guidelines for the staging and follow-up of patients with uterine cervical cancer, and to provide the radiologist with a framework for use in multidisciplinary conferences. Methods: Guidelines for uterine cervical cancer staging and follow-up were defined by the female imaging subcommittee of the ESUR (European Society of Urogenital Radiology) based on the expert consensus of imaging protocols of 11 leading institutions and a critical review of the literature. The results indicated that high field Magnetic Resonance Imaging (MRI) should include at least two T2-weighted sequences in sagittal, axial oblique or coronal oblique orientation (short and long axis of the uterine cervix) of the pelvic content. Axial T1-weighted sequence is useful to detect suspicious pelvic and abdominal lymph nodes, and images from symphysis to the left renal vein are required. The intravenous administration of Gadolinium-chelates is optional but is often required for small lesions (<2 cm) and for follow-up after treatment. Diffusion-weighted sequences are optional but are recommended to help evaluate lymph nodes and to detect a residual lesion after chemoradiotherapy. Expert consensus and literature review lead to an optimized MRI protocol to stage uterine cervical cancer. MRI is the imaging modality of choice for preoperative staging and follow-up in patients with uterine cervical cancer. (orig.)

Balleyguier, Corinne [Radiology Department, Institut Gustave Roussy, Villejuif (France); Sala, E. [Radiology Department, Addenbrooke' s Hospital, Cambridge (United Kingdom); Cunha, T. da [Radiology Department, Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Lisbon (Portugal); Bergman, A. [Department of Radiology, Uppsala University Hospital (Sweden); Brkljacic, B. [Department of Diagnostic and Interventional Radiology, University Hospital ' ' Dubrava' ' , Zagreb (Croatia); Danza, F. [Dipartimento di Bioimmaginie Scienze Radiologiche, Universita Cattolica del S. Cuore, Rome (Italy); Forstner, R. [Zentralroentgeninstitut, Landeskliniken Salzburg, Salzburg (Austria); Hamm, B. [Department of Radiology, Charite Humboldt Universitaet, Berlin (Germany); Kubik-Huch, R. [Institut Radiologie, Kantonsspital Baden, Baden (Switzerland); Lopez, C.; Manfredi, R. [Department of Radiology, ' ' A. Gemelli' ' University Hospital, Rome (Italy); McHugo, J. [Department of Radiology, Birmingham Women' s Hospital, Birmingham (United Kingdom); Oleaga, L. [Radiology Department, Hospital Clinic, Barcelona (Spain); Togashi, K. [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Graduate School of Medicine, Kyoto (Japan); Kinkel, K. [Institut de Radiologie, Clinique des Grangettes, Geneva (Switzerland)

2011-05-15

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Role of chromosome 3p22.3 in the development of uterine cervical cancer  

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Full Text Available AbstractThe aim of this study was to examine the expression of chromosome 3p22.3 and its role in the development of uterine cervical cancer. The 42 unrelated individuals freshly operated specimens from the cervical region with their corresponding normal or peripheral blood leucocytes (PBL were collected from the patients. The specimens were undertaken for microdissection procedure. The detection of human papilloma virus (HPV was done by PCR using the primers MY09 and MY11. The 3p22.3 region appeared to be associated with the development of cervical carcinoma because of significant increase of loss of heterozygosity frequency. The differential deletions in the chromosome 3p22.3 region show that this region plays an important role in the development of the uterine cervical cancer.

Mirunalini Sankaran

2012-04-01

19

The significance of documenting clinical appearance of the uterine cervix in the cervical cytology form.  

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High proportion of cervical smears request did not report clinical appearance of uterine cervix (42.6%. In patients whose cervical smear was reported abnormal (8.2%, 19.6% of them were found with significant intra-epithelial lesion. The clinical appearance of the cervix should be documented on the Pap smear request. Follow up recommendation for Pap smears carried out without clinical appearance description should be left to the clinician.

Hanan M. F. Al-Kadri

2006-11-01

20

Analysis of Treatment Failures in Early Uterine Cervical Cancer  

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One hundred and twenty six patients with early uterine cervical cancer who had been treated at department of Radiation Oncology of Korea University Hospital from jan. 1981 to Dec. 1988 were analysed retrospectively by the treatment result and pattern of failures. All patients had stage la to lla disease and were grouped whether they had combination of operation and postop irradiation or radiation therapy alone. 1) Sixty six patients belonged to the combination treatment group and 60 patients to the radiation alone group. 2) Combination group consisted of 18.1%(12/66)stage la, 71.2%(47/66) stage lb and 10.6%(7/66) stage lla patients. There were no stage la, 18.8%(11/60) stage lb and 81.6%(49/60) stage lla patients for RT alone group. 3) There were total 23%(29/126) treatment failures, 13 patients in combination group and 16 patients in RT alone group. In 66 patients of combination group, they were found to have 5 locoregional failures, 7 distant failures and 1 at both sites. In 60 patients of RT alone group, 9 locoreginal failure and 7 distant failures occurred. Eighty six percent(25/29) of total failures appeared within 18 month after completion of treatment. About 60% of the patients with regional recurrences which were located at pelvic side wall or pelvic lymph nodes presented their recurrent disease after 1 year of completion of treatment, whereas same percent of distant failures appeared within 6 month. 4) In RT alone group, the first sites of distant failure were mostly para-aortic lymph node and/o left supraclavicular lymph node(71.4%, 5/7). In combination group, various sites such as inguinal lymph node, mediastinal lymph node, liver, lung and bone appeared first or at the same time with para-aortic and supraclavicular lymph node metastasis. 5) Logistic regression analysis was done for multivariate analysis of the factors contributing to locoregional and distant failures. In combination group, adequacy of the resection margin and the presence of positive pelvic node were found to be the most significant factors(p=0.0423 and 0.0060 respectively). 6) In RT alone group, less than complete regression of the tumor at the end of treatment was the only significant contributing factor for the treatment failures (p=0.0013) with good likelihood ratio

 
 
 
 
21

Fractionated high-dose-rate brachytherapy in the management of uterine cervical cancer.  

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It is well known that intracavitary radiotherapy (ICR), either alone or in combination with external-beam radiotherapy (EBRT) is an essential component of the radiation treatment of uterine cervical cancer. Although low-dose-rate (LDR) brachytherapy has been successfully applied to the management of such patients, several radiation oncologists have experience of using high-dose-rate (HDR) brachytherapy with promising clinical results over the past 4 decades. However, there has been a considerable reluctance by radiation oncologists and gynecologists in North America to employ the HDR remote afterloading technique instead of the more firmly established LDR treatment modality. In contrast, the HDR-ICR system is rapidly gaining acceptance in Korea since the introduction of the Ralstron, remotely controlled afterloading system using HDR Co-60 sources, at the Yonsei Cancer Center in 1979. According to brachytherapy statistics reported by the Korean Society of Therapeutic Radiology and Oncology, in 1997, brachytherapy was performed upon 1,758 Korean patients with uterine cervical cancer, of whom approximately 83% received HDR brachytherapy. In this review, we present our experiences of HDR-ICR for the treatment of uterine cervical cancer. In addition, we discuss the controversial points, which are raised by those considering the use of HDR-ICR for uterine cervical cancer; these issues include physical and radiobiological considerations, and the prospect of future technical improvements. PMID:12497657

Park, Hee-Chul; Suh, Chang Ok; Kim, Gwi Eon

2002-12-01

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Metastatic Breast Cancer to the Uterine Cervix Mimicking a Giant Cervical Leiomyoma  

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Full Text Available Metastasis to the uterine cervix is a complication of breast cancer that is not commonly known. Detection of cervical metastasis before the diagnosis of the primary tumor is even rarer. The present report describes a case of a 52-year-old woman who had a large cervical tumor appearing as a leiomyoma. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Histopathological examination of the cervical tumor showed patterns characteristic of invasive lobular carcinoma of the breast, leading to the discovery of the primary in the left breast. She subsequently underwent mastectomy, hormone therapy and chemotherapy, and is alive at 7-year follow-up.

MAI HORIKAWA

2012-08-01

23

Fertility-sparing operation for recurrence of uterine cervical perivascular epithelioid cell tumor  

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Full Text Available Perivascular epithelioid cell tumors (PEComa are mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelial cells. Although the uterine corpus seems to be one of the most prevalent sites of involvement, PEComa of the uterine cervix are very rare. Only four cervical PEComa cases have been described, and were treated with hysterectomy and radiotherapy. We report a case of a 24-year-old nulli­gravida woman who presented with acute abdominal pain and was diagnosed with a rupture of an ovarian chocolate cyst. Subsequent surgery revealed that the tumor arose in the uterus, and the histological diagnosis was uterine PEComa with low potential malignancy. Recurrent PEComa in the uterine cervix were excised twice, and she remains disease free 12 months after the last operation. To the best of our knowledge, this is the first report of recurrent cervical PEComa with fertility-preserving surgery. Estimating the malignant potential and appropriate surgery are essential for young patients with uterine PEComa.

Fumitaka Kikkawa

2010-06-01

24

Prediction of prognosis using pretreatment FDG PET in uterine cervical carcinoma  

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In uterine cervical cancer, it is clinically important to predict prognosis on initial staging. We investigated whether abnormally increased FDG uptake of lymph nodes and peak SUV of primary tumor on initial FDG PET can predict prognosis after treatment in cervical patients. Subjects were 74 newly diagnosed cervical cancer patients (50±12yr). Whole body PET was performed after an injection of F-18 FDG. Peak SUV was measured in the primary cervical tumor. Images were interpreted by two nuclear medicine physicians. Follow-up for the disease-free survival was done in all patients. Survival analysis was done by using the Kaplan-Meier method, and a Logrank test was used to compare survival. Cox regression analysis was followed to find independent predictive factors. Recurrence occurred in 13 patients. In univariate analysis, advanced FIGO stage, large size of primary tumor, positive lymph node on MRI of CT, and positive lymph node on PET were significant prognostic factors to predict recurrence. Peak SUV and cell type of tumor failed to show any significant correlation with disease-free survival. In multivariate analysis, positive lymph node on PET (Exp(?)=6.416, p=0.002) and on CT or MRI (Exp(?)=5.711, p=0.026) were independent prognostic factors for predicting recurrence. In uterine cervical cancer, lymph node metastasis of pretreatment FDG PET is the best independent prognostic factor for predicting recurrence. But, peak SUV was not significant prognostic factor not significant prognostic factor

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Cerebellar metastases in patients with uterine cervical cancer. Two cases reports and review of the literature  

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Brain metastases from cervical cancer are extremely rare. We report on two patients who developed cerebellar metastases following uterine cervical cancer. The interval between diagnosis of the primary cancer and diagnosis of brain metastasis was 8 months. The main complaint was symptoms of increased intracranial pressure and cerebellar syndrome. Surgical excision of the brain lesion followed by radiation therapy was performed in the first case. The second patient received palliative radiation therapy. The first patient died 8 months after diagnosis. The second patient is alive 2 months after diagnosis. (authors)

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Therapeutic effect of intra-arterial chemotherapy with DDP and 5-FU via bilateral uterine arteries for advanced uterine cervical cancer  

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Objective: To evaluate the therapeutic effect of intra-arterial chemotherapy with Ddp and 5-Fu via bilateral uterine arteries for advanced uterine cervical cancer. Methods: During the period of Jan. 2006-Jan. 2009, initial intra-arterial chemotherapy by using a combination of Ddp and 5-Fu via bilateral uterine arteries was performed in 72 patients (mean age 42.9 years) with advanced uterine cervical caner. Of 72 patients, stage I b2 cervical cancer was confirmed in 28, stage II a in 12 and stage II b in 32. Pathologically, cervical squamous cell carcinoma was seen in 56 and cervical adenocarcinoma in 16 patients. Ultrasonography and physical examination were conducted both before and after intra-arterial chemotherapy. The therapeutic results,complications,the surgical resection rate and the pathologic findings were observed and statistically analyzed. Results: Fifty-four patients received one treatment course and 18 patients received two treatment courses. The over all response rate was 77.8%. The response rates of patients with I b2, II a and II b cervical cancer were 92.9%, 83.3% and 62.5% respectively, the difference between three groups was statistically significant (P < 0.05). And the response rates of patients with squamous cell carcinoma and adenocarcinoma were 85.7% and 50.0% respectively, the difference between the two was statistically significant (P < 0.05). The most common side-effects included gastrointestinal symptoms and bone marrow suppression. Thirty-four patients received radical hysterectomy,among them, 22 (78.6%) had stage I b2, 8 (66.7%) had stage II a and 4 (12.5%) had stage II b cervical cancer (P < 0.05). Pathologic exam found no vaginal invasion and ovarian metastasis in all 34 patients. The occurrence of metastasis to lymph nodes and para uterine infiltration were 17.6% and 11.8% respectively. Conclusion: Intra-arterial chemotherapy with a combination of DDP and 5-Fu via bilateral uterine arteries can safely and effectively reduce the tumor volume of advanced cervical cancer, suppress the lymph node metastasis and parametrial infiltration, which is very helpful for creating favorable condition required by the surgery and for reducing the manipulative difficulties of radical hysterectomy. Intra-arterial chemotherapy has better effect on stage Ib2 cervical cancer than on stage II a and II b, and it is quite the same that intraarterial chemotherapy is more effective for cervical squamous cell carcinoma than for adenocarcinoma. (authors)

27

Imaging of cervical carcinomas. Imagerie des cancers du col uterin  

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Recently, magnetic resonance imaging (MRI) and transrectal or transvaginal ultrasound (TRUS, TVUS) had an important place in imaging techniques of cervical carcinomas and raise the question of modifying the imaging strategies. For the diagnosis of primitive tumor, those techniques cannot take the place of clinical examination and gross examination. In the assessment of parametrial involvement, TRUS which has better accuracy than clinical examination, and MRI which is considered as the most accurate technique, have an important role to play. In the follow-up and the detection of recurrences, MRI is actually considered as the best imaging technique. The authors, according to recent data in literature and their own experience, present basic concepts of imaging strategies for staging and follow-up of cervical carcinomas.

Soyer, P.; Michel, G.; Masselot, J. (Hopital Louis-Mourier, 92 - Colombes (FR))

1990-12-01

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Uterine cervical ectopy during reproductive age: cytological and microbiological findings.  

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Cervical ectopy is common in adolescents, pregnant women, and those taking high doses of estrogen-containing contraceptives. The majority of cases have spontaneous reversion, but some cases can be persistent. Studies suggested that the adequacy of a Pap smear could be affected and there is an increased risk cervical infections. This study is a cross-sectional study conducted from December 2009 to February 2011 with 457 women with cervical ectopy and 736 without ectopy. Cervical samples were collected in vials for analysis by ThinPrep cytology (Hologic, Marlborough, MA). The Mann-Whitney test and Fisher's exact test (95% CI) were applied. The study was approved by the ethics committee of the Federal University of Ceará. The mean ages of the study group and control group were 28.7 (±14.8) and 33.6 (±7.5) years old, respectively (P?

Junior, José Eleutério; Giraldo, Paulo César; Gonçalves, Ana Katherine Silveira; do Amaral, Rose Luce Gomes; Linhares, Iara Moreno

2014-05-01

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Uterine cervical carcinoma after therapy: CT and MR imaging findings.  

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Cervical carcinoma is one of the most frequent causes of death in women. Computed tomography (CT) and magnetic resonance (MR) imaging are the primary modalities for follow-up of treated cervical carcinoma. A normal vaginal cuff after hysterectomy appears as a smooth, low-signal-intensity muscular wall on T2-weighted MR images. Early (2-3 months after treatment) and significant decreases in the signal intensity and volume of the tumor at MR imaging indicate a good response to radiation therapy. Sites of recurrence are the pelvis, lymph nodes, and distant sites. Pelvic recurrence appears as a heterogeneously enhancing mass at contrast material-enhanced CT and often appears as a heterogeneous, high-signal-intensity mass at T2-weighted MR imaging. Lymph node recurrence ranges from scattered, minimally enlarged nodes to large, conglomerate nodal masses. Determination of neoplastic infiltration of lymph nodes is based on size; most researchers consider nodes greater than 1 cm in short-axis diameter to be metastatic. Distant metastases are usually due to recurrent disease and occur in the abdomen, thorax, and bone. Knowledge of the normal therapeutic changes and the spectrum of recurrent tumor in patients with cervical carcinoma is important for accurate interpretation of follow-up CT and MR images. PMID:12853673

Jeong, Yong Yeon; Kang, Heoung Keun; Chung, Tae Woong; Seo, Jeong Jin; Park, Jin Gyoon

2003-01-01

30

Incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients  

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Full Text Available Abstract Background Renal allograft recipients are reported to have a higher incidence of malignancy than the general population. This single hospital-based study examined the incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients. Methods Among 453 women receiving renal transplantation from January 1990 to December 2008, 5 patients were diagnosed with cervical carcinoma. Medical records of these 5 patients were retrospectively reviewed, and clinicopathologic data were collected and analyzed. Results The incidence of cervical carcinoma in renal transplant recipients was 58.1 out of 100,000 per year, which is 3.5 times higher than in the general Korean population. The mean interval between the time of renal transplantation and the time of cervical carcinoma diagnosis was 80.7 months. After a median follow-up of 96.2 months, there was no recurrence of the disease or death. In 4 patients who were positive from human papillomavirus in situ hybridization (HPV ISH, high or probably high risk HPV DNA was detected in all. Punctate staining of HPV ISH was detected in 3 out of 4 patients. Conclusions Higher incidence of cervical carcinoma is expected in renal transplant recipients, so appropriate surveillance is needed to ensure early detection and treatment of cervical carcinoma.

Hur Soo Young

2011-07-01

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Pelvic insufficiency fracture after definitive radiotherapy for uterine cervical cancer. Retrospective analysis of risk factors  

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The purpose of this study is to determine the incidence, clinical characteristics and risk factors of postradiation pelvic insufficiency fracture (PIF) in women with uterine cervical cancer. We reviewed the medical records of 126 patients who received definitive radiotherapy (RT) for uterine cervical cancer between 2003 and 2009 at our institution. Among them, 99 patients who underwent at least one computed tomography (CT) or magnetic resonance imaging of the pelvis during their follow-up at more than 6 months were included in this analysis. The relationship between the incidence of PIF and several patient- and treatment-related factors was analyzed. The median follow-up period was 21 months. Of the 126 patients, 33 (with a total of 50 lesions) were diagnosed with PIF. The 2-year cumulative incidence was 32%. Univariate analysis showed that age ?70 years (P= 0.0010), postmenopausal state (P = 0.0013), and lower CT density of bone and bone marrow (P = 0.020) significantly related to PIF. In a multivariate analysis, of the 59 patients whose CT densities were evaluable, lower CT density was the only significant factor associated with PIF (P = 0.0026). In conclusion, postradiation PIFs were detected in a considerable number of patients after definitive RT for cervical cancer. Predisposing factors were older age, postmenopausal state, and decreased density of bone and bone marrow on CT. (author)

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The opioid neuropeptides in uterine fibroid pseudocapsules: a putative association with cervical integrity in human reproduction.  

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The myoma pseudocapsule (MP) is a fibro-vascular network rich of neurotransmitters, as a neurovascular bundle, surrounding fibroid and separating myoma from myometrium. We investigated the distribution of the opioid neuropeptides, as enkephalin (ENK) and oxytocin (OXT), in the nerve fibers within MP and their possible influence in human reproduction in 57 women. An histological and immunofluorescent staining of OXT and ENK was performed on nerve fibers of MP samples from the fundus, corpus and isthmian-cervical regions, with a successive morphometric quantification of OXT and ENK. None of the nerve fibers in the uterine fundus and corpus MPs contained ENK and the nerve fibers in the isthmian-cervical region demonstrated an ENK value of up to 94?±?0.7?CU. A comparatively lower number of OXT-positive nerve fibers were found in the fundal MP (6.3?±?0.8?CU). OXT-positive nerve fibers with OXT were marginally increased in corporal MP (15.0?±?1.4?CU) and were substantially higher in the isthmian-cervical region MP (72.1?±?5.1?CU) (p?uterine corpus, while are highly present into the cervico-isthmic area, with influence on reproductive system and sexual disorders manifesting after surgical procedures on the cervix. PMID:23937196

Malvasi, Antonio; Cavallotti, Carlo; Nicolardi, Giuseppe; Pellegrino, Marcello; Vergara, Daniele; Greco, Marilena; Kosmas, Ioannis; Mynbaev, Ospan A; Kumakiri, Jun; Tinelli, Andrea

2013-11-01

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Lumboaortic irradiation in uterine cervical cancer: Analysis of the literature  

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Background: Uterine cancer is a prevalent disease in Chile and it is one of the most frequent cancer locations treated in the National Chilean Cancer Institute. It is also common to receive young patients that have advanced tumors in stages IIB and IIIB with high risks of compromises of lymphatic nodes of pelvis and aortic-lumbar zones. The treatment for these kinds of cancers is radio-chemotherapy. Aims: Determinate if the radiotherapy of aortic-lumbar lymph nodes lowers the chance of relapsing or increase the survival rate in patients with evident compromise of aortic-lumbar lymph nodes and in those with high risk of compromise in that level. Method: Exhaustive analysis of the literature about the indication of radiotherapy of aortic-lumbar lymph nodes in cervix cancer which is classified in those where the radiotherapy treatment is done in patients with evident compromise of aortic-lumbar lymph-nodes, and those where de radiotherapy is done in patients with high risk of compromise in that level. Results: In patients with small cervix tumors and positive lymphoid nodes the LA lymphatic nodes treatment would be beneficial. However, patients that suffer massive pelvic disease (IIIB) or that have evidence of the disease, the benefit would not be so important. Conclusion: Patients with controllable pelvic disease and with high risk of having aortic-lumbar lymph nodes compromise are the most benefit of radiotherapy in aortic-lumbar lymph nodes (stages IA-B, IIA-B with positive lymph nodes)

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Extended pelvic resections for recurrent uterine and cervical cancer: out-of-the-box surgery.  

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Patients with recurrent uterine and cervical cancer have poor prognoses. The objective of this study was to analyze the outcomes of patients with recurrent uterine and cervical cancer who had undergone attempted curative resection of pelvic bone, sidewall muscle, major blood vessels, and/or nerves. We reviewed the records of all 14 patients with recurrent uterine and cervical cancer who had extended pelvic resections at our institution between June 2000 and November 2006. Primary sites of disease were the uterus (11 patients) and cervix (3 patients). Tumor histology was as follows: adenocarcinoma, seven; squamous cell carcinoma, three; leiomyosarcoma, three; and adenosarcoma, one. Previous treatment included hysterectomy, 11; pelvic radiation, 9; chemotherapy, 9; and total pelvic exenteration, 2. Extended pelvic resections included removal of pelvic sidewall muscle, five; bone, five; common and/or external iliac vessel, five; femoral nerve, two; lumbosacral nerve root, one; and obturator nerve, one. Other procedures included total pelvic exenteration, three; posterior exenteration, two; and anterior exenteration, one. Complete resection with negative margins was obtained in 11 (78%) of 14 patients. Seven patients (50%) received high-dose rate intraoperative radiation therapy. Reconstructive procedures included continent or incontinent urinary diversion, four; femoral-femoral arterial bypass, two; myocutaneous flap, two; and urinary ileal interposition, one. Median total operating time was 628 min (range, 345-935 min) and median estimated blood loss was 900 mL (range, 300-16,000 mL). Seven patients (50%) had one or more major complication(s), including pelvic abscess, three; colonic fistula, two; massive intraoperative hemorrhage, one; postoperative bladder perforation, one; thrombosed femoral-femoral graft, one; and disruption of appendicocutaneous urinary anastomosis, one. At a median follow-up of 26 months (range, 5-84 months), ten patients (71%) are alive and four patients (29%) have died of disease at 8, 13, 33, and 42 months postoperatively. PMID:18053063

Caceres, A; Mourton, S M; Bochner, B H; Gerst, S R; Liu, L; Alektiar, K M; Kardos, S V; Barakat, R R; Boland, P J; Chi, D S

2008-01-01

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An analysis of prognostic factors in the uterine cervical cancer patients  

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The aim of this study is to analysis of survival and recurrence rates of the uterine cervical carcinoma patients whom received the radiation therapy respectively. The prognostic factors, such as Papanicolaou (Pap) smear, carcinoembriogenic antigen (CEA) and squamous cell carcinoma (SCC) antigen has been studied. From January 1981 to December 1998, eight-hundred twenty-seven uterine cervical cancer patients were treated with radiation therapy. All of the patients were divided into two groups: the radiation therapy only (521 patients) group and the postoperative radiation therapy (326 patients) group. The age, treatment modality, clinical stage, histopathology, recurrence, follow-up Pap smears, CEA and see antigen were used as parameters for the evaluation. The prognostic factors such as survival and recurrence rates were performed with the Kaplan-Meier method and the Cox hazard model, respectively. Median fallow-up was 38.6 months. On the radiation therapy only group, 314 patients (60%) achieved complete response (CR), 47 patients (9%) showed local recurrence (LR), 78 patients (15%) developed distant metastasis (DM). On the postoperative radiation therapy group, showed 276 patients (85%) CR, 8 patients (2%) LR, 37 patients (11%) DM. The 5-year survival and recurrence rates was evaluated for all parameters. The statistically significant factors for the survival rate in univariate analysis were clinical stage (p=0.00001), treatment modality (p=0.0010), recurrence (p=0.00nt modality (p=0.0010), recurrence (p=0.0001), Pap smear (p=0.0329), CEA (p=0.0001) and SCC antigen (p=0.0001). This study indicated that after treatment, the follow-up studies of Pap smear, CEA and SCC antigen were significant parameter and prediction factors for the survival and recurrence of the uterine cervical carcinoma

36

An analysis of prognostic factors in the uterine cervical cancer patients  

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The aim of this study is to analysis of survival and recurrence rates of the uterine cervical carcinoma patients whom received the radiation therapy respectively. The prognostic factors, such as Papanicolaou (Pap) smear, carcinoembriogenic antigen (CEA) and squamous cell carcinoma (SCC) antigen has been studied. From January 1981 to December 1998, eight-hundred twenty-seven uterine cervical cancer patients were treated with radiation therapy. All of the patients were divided into two groups: the radiation therapy only (521 patients) group and the postoperative radiation therapy (326 patients) group. The age, treatment modality, clinical stage, histopathology, recurrence, follow-up Pap smears, CEA and see antigen were used as parameters for the evaluation. The prognostic factors such as survival and recurrence rates were performed with the Kaplan-Meier method and the Cox hazard model, respectively. Median fallow-up was 38.6 months. On the radiation therapy only group, 314 patients (60%) achieved complete response (CR), 47 patients (9%) showed local recurrence (LR), 78 patients (15%) developed distant metastasis (DM). On the postoperative radiation therapy group, showed 276 patients (85%) CR, 8 patients (2%) LR, 37 patients (11%) DM. The 5-year survival and recurrence rates was evaluated for all parameters. The statistically significant factors for the survival rate in univariate analysis were clinical stage (p=0.00001), treatment modality (p=0.0010), recurrence (p=0.0001), Pap smear (p=0.0329), CEA (p=0.0001) and SCC antigen (p=0.0001). This study indicated that after treatment, the follow-up studies of Pap smear, CEA and SCC antigen were significant parameter and prediction factors for the survival and recurrence of the uterine cervical carcinoma.

Yang, Dae Sik; Yoon, Won Sub; Kim, Tae Hyun; Kim, Chul Yong; Choi, Myung Sun [College of Medicine, Korea Univ., Seoul (Korea, Republic of)

2000-12-01

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Can MRI predict local control rate of uterine cervical cancer immediately after radiation therapy?  

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The purpose of this study was to evaluate the utility of measuring the volumes of areas of high signal intensity on T2-weighted magnetic resonance (MR) images immediately after irradiation for predicting the local control rate of uterine cervical cancer. From our departmental database, we identified 109 patients with cervical cancer who underwent MR imaging before irradiation and just before or just after completion of radiation therapy from 1994 to 2007. We included 46 of the 109 patients in this study, 5 patients with local recurrence and 41 patients who were free of disease for more than 2 years. Fifteen received radiation therapy alone, and 28 patients received concurrent chemoradiation therapy. We measured the volumes of areas of high signal intensity involving the uterine cervix on T2-weighted MR images before radiation therapy and just before or just after its completion. We measured the 3 orthogonal diameters to calculate the volume as an ellipsoid and evaluated proportional tumor volume and the rate of reduction. We analyzed statistics with Student's t-test. In patients with local recurrence, the mean volume of the areas of high signal intensity on T2-weighted MR images just before completion of irradiation therapy or just after was 19.70 cm3, which was significantly larger than that in patients without recurrence (1.77 cm3, P2-weighted MR images include acute radiation change, their volume and the proportional tumor volume after irradiation can be useful clues in predicting the local control rate of uterine cervical cancer. (author)

38

Radiation-induced changes of immune parameters in patients of uterine cervical cancer  

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Changes induced by therapeutic irradiation in uterine cervical cancer patients were studied. In peripheral blood lymphocytes and their subpopulations, number of lymphocytes, total E-RFC, active E-RFC and blastic transformation were decreased, and immune skin response weakened by irradiation. These changes were most exaggerated a few weeks after radiotherapy started, and its recovery was very slow. In a group of recurrent cancer, recovery of immune parameters was much delayed. In irradiated patients whose immune activity has been suppressed and its effect continues, adjunct immune therapy is thought to be necessary. (Ueda, J.)

39

Solitary cerebellous metastasis after prolonged remission in a case of uterine cervical adenocarcinoma.  

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Intracranial metastasis of a uterine cervical carcinoma is a very rare occurrence. These metastases are characteristically multiple, supra-tentorial, associated with multiple systemic dissemination, usually occur relatively late in the course of the disease, and are most often seen in squamous carcinomas. We present an unusual case which defied these characteristics. This patient was in long-term remission (11 years), presented with a solitary cerebellous metastases, had no evidence of other systemic spread, and the pathology was an adenocarcinoma. We present this rare case with interesting clinical ramifications. This is probably the longest duration of remission prior to the metastasis in the published literature. PMID:22865975

Dadlani, Ravi; Ghosal, Nandita; Hegde, Alangar Sathya

2012-05-01

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Usage of CT and tumor markers in the management of a patient with cervical cancer after colpocleisis for uterine prolapse  

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A 79-year-old woman developed stage IIIb cervical carcinoma 13 years after colpocleisis for uterine prolapse. The patient was treated with external irradiation of 60 Gy and chemotherapy with 5-FU (100 mg/day) and Ok-432. The response of tumor could be monitored by serial changes in tumor markers, such as SCC, IAP, TPA, CEA, LDH, and ALP, and CT findings. Considering that colpocleisis makes it impossible to visualize the uterine cervix, the adequate selection of surgical procedure for uterine prolapse is required. (Namekawa, K.)

 
 
 
 
41

Immunologic treatments for precancerous lesions and uterine cervical cancer.  

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Development of HPV-associated cancers not only depends on efficient negative regulation of cell cycle control that supports the accumulation of genetic damage, but also relies on immune evasion that enable the virus to go undetected for long periods of time. In this way, HPV-related tumors usually present MHC class I down-regulation, impaired antigen-processing ability, avoidance of T-cell mediated killing, increased immunosuppression due to Treg infiltration and secrete immunosuppressive cytokines. Thus, these are the main obstacles that immunotherapy has to face in the treatment of HPV-related pathologies where a number of different strategies have been developed to overcome them including new adjuvants. Although antigen-specific immunotherapy induced by therapeutic HPV vaccines was proved extremely efficacious in pre-clinical models, its progression through clinical trials suffered poor responses in the initial trials. Later attempts seem to have been more promising, particularly against the well-defined precursors of cervical, anal or vulvar cancer, where the local immunosuppressive milieu is less active. This review focuses on the advances made in these fields, highlighting several new technologies (such as mRNA vaccine, plant-derived vaccine). The most promising immunotherapies used in clinical trials are also summarized, along with integrated strategies, particularly promising in controlling tumor metastasis and in eliminating cancer cells altogether.After the early promising clinical results, the development of therapeutic HPV vaccines need to be implemented and applied to the users in order to eradicate HPV-associated malignancies, eradicating existing perception (after the effectiveness of commercial preventive vaccines) that we have already solved the problem. PMID:24667138

Vici, Patrizia; Mariani, Luciano; Pizzuti, Laura; Sergi, Domenico; Di Lauro, Luigi; Vizza, Enrico; Tomao, Federica; Tomao, Silverio; Cavallotti, Claudia; Paolini, Francesca; Venuti, Aldo

2014-01-01

42

Effect of subclinical uterine infection on cervical and uterine involution, estrous activity and fertility in postpartum buffaloes.  

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Nili-Ravi buffaloes (n=29) that calved normally between August and November and did not develop any clinical reproductive disorder after calving were studied for the incidence of sub-clinical bacterial infection of the uterus and its effects on postpartum reproductive efficiency. The incidence of subclinical uterine infection was 24% (7/29). Involution of the cervix and uterus was slower (P buffaloes of the two groups. However, the rate of involution of the cervix and the gravid horn was lower in buffaloes of the infected group (2.2 vs. 2.7 mm/day and 2.6 vs. 3.2 mm/day). The mean interval to first post partum ovulation was similar in buffaloes in the infected (35.5 days) and the normal group (33.8 days). The life span of corpus luteum formed after first ovulation was shorter (11 days) in buffaloes of both groups than that of a normal estrous cycle (15 to 17 days). The incidence of silent ovulation was apparently higher in buffaloes of the infected group (83 vs. 60%) but the difference was not significant. For the first four months after calving, the mean interval to first postpartum estrus was longer in buffaloes of the infected group (73.0 vs. 47.7 days; P buffaloes of the infected group (91.0 vs. 64.8 days; P buffaloes of the two groups. We conclude that subclinical bacterial infection of the postpartum uterus delays the cervical and uterine involution which can, in turn, delay the occurrence of first postpartum estrus and prolong the service period in buffaloes. PMID:11233783

Usmani, R H; Ahmad, N; Shafiq, P; Mirza, M A

2001-01-15

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Radiotherapy of Uterine Cervical Cancer Using Fletcher-Suit-Delclos Cesium Applicator  

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From Nov. 1983 through Feb. 1986, 35 patients of uterine cervical cancer were treated by external radiation therapy and intracavitary radiation therapy using Fletcher-Sult-Delclos applicator. Age of the patients ranged from 32 to 70 years (median age:53 years). All patients had follow up from 9 to 34 months and median follow up of 20 months. 4 patients were in stage I, 25 were in stage II, 5 were in stage III and I was in stage IV. Overall regression rate was 80% and uncorrected actuarial 2 year survival rate was 88%. The incidence of rectal complications were analyzed. There was no rectal complication in the patients who received less than 7000 rad maximal rectal dose, but 2 out of 17 patients who received more than 7000rad developed moderate degree (grade 2) of rectal complication. In viewing of our results, Fletcher-Suit-Delclos applicator (3M) seemed to be an appropriate instrument for intracavitary radiation therapy in the patients of uterine cervical cancer

44

CT and ultra low field (0.02 T) MR imaging of uterine cervical carcinoma  

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Nineteen pelvic MR and 21 CT examinations were performed in 21 patients with uterine cervical carcinoma. The results were compared with clinical (FIGO) staging in all patients, and with the histopathologic results after operation in 8. In the evaluation of local tumor growth CT agreed with clinical staging in 29%, MR imaging with clinical staging in 47% and CT with MR in 53%. The greatest discrepancy between the imaging methods and clinical examination was in the evaluation of parametrial extension. From 8 Stage I tumors with surgical confirmation the local tumor growth was overestimated with CT in 3 cases, with clinical examination in 2 and with MR imaging in 2 cases. CT and MR imaging at 0.02 T did not differ in the evaluation of parametrial tumor growth. Clinical examination overestimated parametrial growth but was relatively accurate in detecting vaginal wall involvement. MR imaging at 0.02 T is a convenient, inexpensive and accurate method for the local staging of early uterine cervical carcinoma. (orig.)

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Case Report: Uterine Adenocarcinoma Metastasis to the Skull Base and Cervical Spine Presenting with Pathological Fracture and Myelopathy  

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Full Text Available Objective: The authors report a rare case of uterine adenocarcinoma metastasis to both the skull base and cervical spine presenting with pathological fracture and myelopathy. Methods: We report the case of a 43-year-old Asian female with widely metastatic uterine adenocarcinoma who over the course of 3 years was diagnosed with a large clival mass and more recently a cervical spine pathological fracture presenting with myelopathy. Results: This patient underwent multiple procedures over a three-year period, including total hysterectomy with tumor debulking, endonasal biopsy of clival mass and most recently cervical corpectomy and fusion. She has received chemotherapy and radiation therapy for treatment of the unresectable clival mass and has done quite well despite having this pathology. Conclusion: This is the first documented case of clival involvement of endometrial adenocarcinoma. Additionally, this is a unique case of spinal metastatic endometrial adenocarcinoma presenting with pathological fracture and myelopathy.

Paul E. Kaloostian

2013-07-01

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Obstetric performance of a patient with multiple uterine and cervical fibroids and expectant management of retained placenta.  

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The aim of this case report is to describe the obstetric performance of a patient with multiple uterine and supravaginal cervical fibroids. A 36-year-old, gravida 3 para 0+2 with multiple uterine and cervical fibroids presented with inevitable abortion at 17 weeks gestation. She had a spontaneous rupture of membranes followed by expulsion of fetus as breech with entrapment of aftercoming head by a cervical fibroid. Oxytocin infusion and digital traction were able to deliver the fetus. The placenta, however, was trapped in the fundal area and could not be delivered under general anesthesia because of mechanical obstruction by the fibroid. Expectant management was successful in expulsion of the placenta within 7 days without complication.

Mahfuza H. Begum

2002-11-01

47

Clinical significations of G2-M stage partial synchronization on radiation therapies of uterine cervical carcinomas  

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The present study revealed that irradiation-induced changes of repopulation and redistribution played an important role in radiosensitivity and cure process of human uterine cervical carcinoma. DNA measurements by a microspectrophotometer were made on Feulgen stained biopsy specimens obtained from 20 patients. On the other hand, flow-microfluorometric measurements with Fried's computed cell cycle analysis were made on transplanted human cervical carcinomas. The mean nuclear DNA amount of human cervical carcinoma cells increased according as the irradiation doses increase until 2,000 rad. Moreover, as regards with the mean nuclear diameter of cancer cells the same phenomenon was recognized, and there was an interrelation between the increase of mean nuclear DNA amount and that of mean nuclear diameter. This phenomenon was proved in nuclear DNA analysis by flow-microfluorometric measurements on transplanted human cervical carcinoma in nude mice. Computed cell cycle analysis of F.M.F. data demonstrated that this phenomenon was due to irradiation-induced changes of repopulation and redistribution. That is to say, irradiation induces the increase of cycling cells and then partial synchronization to G2-M stage. Examination of the interrelation between this phenomenon at 500 rad and 5 years survival rate demonstrated that there was more increase of nuclear DNA amount in the good prognosis group than in the poor prognosis group. Estimation of residual cells near the G1 stage at 2,000 rad demonstrated that there were more residual cells near the G1 stage in the poor prognosis group than in the good prognosis group. (author)

48

Assessment of the natural course and treatment of premalignant uterine cervical lesions in pregnancy  

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Full Text Available Introduction. Premalignant changes of the uterine cervix occur with similar frequency during pregnancy and in non­pregnant women. Due to the fact that any surgery on the cervix can jeopardize pregnancy, it is important to define the protocol of procedures for the treatment of these changes during pregnancy. Objective. The aim of the study was to investigate the natural course of premalignant cervical changes during pregnancy and the impact of their treatment on the pregnancy course. Methods. Study involved all patients with colposcopically, cytologically and hystopathologically diagnosed premalignant cervical changes during pregnancy from 2002 to 2008. Patients were divided into two groups according to the applied treatment during pregnancy: surgery or monitoring by regular colposcopic and cytological examinations. The two groups were compared concerning treatment outcome, persistence or regression of changes and pregnancy duration. Results. Study involved 58 patients. Spontaneous remission of lesions occurred after pregnancy in 63.79% of cases. Highgrade squamous intraepithelial lesion (H­SIL demonstrated a higher rate of persistency in comparison with low­grade squamous intraepithelial lesion (L­SIL (?2=25.115; p<0.05. Only one finding of L­SIL progressed into H­SIL in the monitored group. Patients who underwent conization during pregnancy had a significantly more frequent preterm deliveries (?2=14.369; p<0.05. Conclusion. The obtained high rate of spontaneous regression of cervical changes after pregnancy as well as the lower incidence of preterm births in patients who were not treated by conization during pregnancy, confirm that patients with premalignant cervical changes should be, if invasion is excluded, under follow­up throughout pregnancy by regular colposcopic and cytological examinations. Therapeutic conization, due to numerous complications, should be performed only when there is a suspected presence of a more severe form of the disease (micro invasive and invasive carcinoma.

Šljivan?anin Dragiša

2013-01-01

49

Integrative review of the nursing interventions used for the early detection of cervical uterine cancer.  

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In a national program to combat cervical uterine cancer (CUC) four basic elements should exist: primary prevention, early detection, diagnosis/treatment and palliative care. Of these, early detection is the most effective modality. One of the purposes of Evidence-Based Practice (EBP) is to encourage the use of research results with the assistance provided, reinforcing the importance of research for clinical practice. This study aimed to evaluate the evidence available in the literature regarding effective nursing interventions for the early detection of CUC. The selection of articles was performed in the databases: Scopus, PubMed, CINAHL, Lilacs and Cochrane. The sample of this review consisted of seven articles, with evidence levels 1, 2 or 3. The behavioral, cognitive and social interventions, showed positive effects in the early detection of CUC, especially the interactive cognitive interventions. It is suggested, when appropriate, to use a combination of interventions in order to obtain a more effective result. PMID:21584393

Vasconcelos, Camila Teixeira Moreira; Damasceno, Marta Maria Coelho; Lima, Francisca Elisângela Teixeira; Pinheiro, Ana Karina Bezerra

2011-01-01

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Estimation of radiosensitivity using serial biopsy and serial cytology; Examination in uterine cervical cancer  

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Eleven patients with uterine cervical cancer received whole pelvic irradiation of a total dose of 50 Gy and intracavitary irradiation with radical intent. Patients were clinically staged as Stage IIa (one), Stage IIb (4), Stage IIIb (4), and Stage IVa (2). Biopsy was done after irradiation of 10 Gy for histological examination. Cytological findings - including the number of cancer cells, enlargement of cells, cytoplasm staining, vacuolization, nuclear degeneration, and manifestations of polykaryocytes, giant nuclear cells, or pathologic mitosis - were examined before and after irradiation of 10, 20, and 30 Gy. Local primary effectiveness of irradiation tended to be associated with histological findings. Serial cytological examination revealed the strongest correlation between local primary effects and the number of cancer cells. The aforementioned cytological findings tended to occur earlier and more frequently in the more sensitive group to radiation. Serial biopsy and cytology may aid in the clinical evaluation for radiosensitivity, contributing to the individualization and optimization of radiation therapy. (N.K.).

Mariya, Yasushi; Watanabe, Sadao; Yokoyama, Yoshiaki (Aomori Prefectural Central Hospital (Japan)) (and others)

1990-06-01

51

Ploidy, cytokinetics, and histology features of aggressive versus less aggressive uterine cervical squamous cell carcinomas  

International Nuclear Information System (INIS)

The authors are investigating the interrelationships of flow cytometric measured ploidy, S-fraction with histology features of uterine cervical squamous cell cancers in an attempt to identify aggressive, high risk tumors and less aggressive tumors. Experimentally, pre-radiotherapy biopsy specimens are being studied using flow ploidy and cell-cycle analysis and microscopic scoring for histology features. The results to date for some 200 patients indicate that there are identifyable aggressive tumors, at high risk for 2 yr local control within each stage of disease and differentiation category (WD, MD, PD). These aggressive tumors usually have high degree DNA abnormalities (triploid or greater), high proliferative activity (%S?20) compared to the less aggressive tumors characterized by diploid/near diploid DNA content, low to moderate %S (2-19, mean 12). Expression of high S-fraction appears to reflect high growth activity or growth potential and characterizes the aggressive tumors

52

Results of combined therapy of irradiation and bleomycin suppository for advanced uterine cervical cancer  

International Nuclear Information System (INIS)

Efficacy, survival rats and adverse effects of the combined therapy of irradiation with intravaginal bleomycin suppositories were analyzed and discussed in 49 patients with uterine cervical cancer. The results were as follows: 1. Histological examination of biopsy specimens from the uterine cervix taken just after the completion of this treatment showed favorable control over the primary lesions. However, the efficacy of the bleomycin suppositories was too mild to form a basis for treatment without intracavitary irradiation. Because of the low concentration of bleomycin in serum after suppository administration, it is thought that bleomycin would have little effect on distant metastases. 2. Survival rates in stage III patients were 83% at 12 months, 77% at 24 months and 70% at 36 months. These were superior to those for irradiation alone. 3. The major adverse effect of bleomycin suppositories was fever, reduction of the bleomycin dose in each suppository but controlled this to some extent Lung fibrosis or severe damage to the liver, kidney and bone marrow were not found. (author)

53

Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro.  

Science.gov (United States)

Increased numbers of mast cells is a typical feature of a variety of human cancers. The major mediators in the secretory granules of the MC(TC) type of mast cells, serine proteinases tryptase and chymase, may be involved in squamous cell carcinoma (SCC) lesions by inducing matrix remodeling and epithelial cell detachment. The objective of this study was to analyze immunohistochemically whether MC(TC) mast cells as well as protease inhibitors, squamous cell carcinoma antigens (SCCAs), are present in the uterine cervical SCC. In addition, the effect of tryptase and chymase on uterine cervical SCC cell lines was studied in vitro. Here we report that tryptase- and chymase-positive mast cells are present in significant numbers in the peritumoral stroma of SCC lesions. Also, weak SCCA-2 immunoreactivity is observed in the SCC lesions, but only SCCA-1 in uterine cervical specimens with nonspecific inflammation. In cell cultures, especially chymase, but not tryptase, was shown to induce effective detachment of viable, growing and non-apoptotic SiHa SCC cells from substratum. Chymase also detached viable ME-180 SCC cells from substratum as well as degraded fibronectin. In contrast, normal keratinocytes underwent apoptotic cell death after similar prolonged chymase treatment. No inhibition of chymase was detected by SiHa cell sonicates nor did these cells express marked SCCA immunopositivity. MC(TC) mast cells containing tryptase and chymase are present in the peritumoral stroma of uterine cervical SCC and the malignant cells are only weakly immunoreactive for the chymase inhibitor SCCA-2. It is chymase that appears to be capable of inducing effective detachment of viable and growing SCC cells and therefore, it may release SCC cells from a tumor leading to spreading of malignant cells. PMID:21274549

Diaconu, Nicolae-Costin; Rummukainen, Jaana; Naukkarinen, Anita; Mättö, Mikko; Harvima, Rauno J; Pelkonen, Jukka; Harvima, Ilkka T

2011-09-01

54

Clinical significance of magnetic resonance imaging (MRI) in evaluation of radiotherapeutic effect on uterine cervical cancer  

International Nuclear Information System (INIS)

Serial magnetic resonance imaging (MRI) studies were performed in 27 patients undergoing primary radiation therapy for invasive cervical carcinoma, to assess the efficacy of this therapy. MRI findings included a high intensity area (HIA) in the uterine cervix and five parameters indicative of extrauterine spreading of the carcinoma: vaginal invasion, parametrial invasion, vesical invasion, rectal invasion and lymph node enlargement. In 26 of the 27 (96%) cases, the HIA was found prior to treatment, and remained in 17 (63%) cases at the end of the treatment. But in 10 of the patients with a residual HIA, this region resolved 3 to 8 months after treatment, and these patients had no evidence of residual tumor in the cervix on pathologic examination. The accuracy was lower in MRI examinations performed less than 6 months after the treatment (49%) than in examinations performed more than 7 months after the treatment (93%), suggesting that the HIA in the early post-treatment phase may be related to inflammatory changes. Findings indicative of extrauterine spreading decreased following treatment, but patients with recurrence had higher scores than those with no evidence of recurrence completion of the primary therapy. Furthermore, in 2 patients with local recurrence more than 1 year after treatment, the abnormal MRI findings reappeared and increased after the initial resolution of these findings with treatment. The present results indicate that MRI is clinically effective in evaluating the effects of radiotherapy in patients with cervical cancer. (author)

55

Clinical significance of magnetic resonance imaging (MRI) in evaluation of radiotherapeutic effect on uterine cervical cancer  

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Serial magnetic resonance imaging (MRI) studies were performed in 27 patients undergoing primary radiation therapy for invasive cervical carcinoma, to assess the efficacy of this therapy. MRI findings included a high intensity area (HIA) in the uterine cervix and five parameters indicative of extrauterine spreading of the carcinoma: vaginal invasion, parametrial invasion, vesical invasion, rectal invasion and lymph node enlargement. In 26 of the 27 (96%) cases, the HIA was found prior to treatment, and remained in 17 (63%) cases at the end of the treatment. But in 10 of the patients with a residual HIA, this region resolved 3 to 8 months after treatment, and these patients had no evidence of residual tumor in the cervix on pathologic examination. The accuracy was lower in MRI examinations performed less than 6 months after the treatment (49%) than in examinations performed more than 7 months after the treatment (93%), suggesting that the HIA in the early post-treatment phase may be related to inflammatory changes. Findings indicative of extrauterine spreading decreased following treatment, but patients with recurrence had higher scores than those with no evidence of recurrence completion of the primary therapy. Furthermore, in 2 patients with local recurrence more than 1 year after treatment, the abnormal MRI findings reappeared and increased after the initial resolution of these findings with treatment. The present results indicate that MRI is clinically effective in evaluating the effects of radiotherapy in patients with cervical cancer. (author).

Iizuka, Yoshihiro [Kyorin Univ., Mitaka, Tokyo (Japan). School of Medicine

1996-01-01

56

Changes in Bone Mineral Density in Uterine Cervical Cancer Patients After Radiation Therapy  

International Nuclear Information System (INIS)

Purpose: To prospectively investigate the changes in bone mineral density (BMD) after pelvic radiation therapy in patients with uterine cervical cancer. Methods and Materials: Of 52 cervical cancer patients who received pelvic RT in our university hospital between 2009 and 2011, 46 patients without recurrence and who were followed up for more than 12 months were included in the study. The BMD of the irradiated region and nonirradiated regions, serum estradiol, tartrate-resistant acid phosphatase-5b, and N-terminal cross-linking telopeptide of collagen 1 were measured before, at 3 months after, and at 12 months after RT. The patient cohort was divided into 2 groups according to estradiol level before RT, and the groups were defined as postmenopausal (2 before RT and 0.746 and 0.841 g/cm2 12 months after RT, respectively. Significant decreases were observed in both groups (P2 before RT and were significantly decreased to 0.706 and 0.921 g/cm2 12 months after RT (P<.01 and P<.05, respectively). Estradiol significantly decreased 3 months after RT, whereas tartrate-resistant acid phosphatase-5b and N-terminal cross-linking telopeptide of collagen 1 continued to increase over time in the premenopausal group. Conclusions: A decrease in BMD in the irradiated region after RT was observed within 1 year, regardless of menopausal status. Furthermore, in premenopausal patients, pelvic RT caused a decrease in systemic BMD

57

Factores de riesgo para cáncer de cuello uterino Risk factors for uterine cervical cancer  

Directory of Open Access Journals (Sweden)

Full Text Available El cáncer del cuello uterino es una de las neoplasias malignas de mayor incidencia y mortalidad entre las mujeres de todas partes del mundo, hallazgo que resulta paradójico si se tiene en cuenta que el cuello uterino es de fácil acceso y existen estrategias debidamente probadas que permiten un diagnóstico y tratamiento precoz. En esta revisión se describe detalladamente la epidemiología del cáncer del cuello uterino, en especial los factores de riesgo relacionados con la génesis de la neoplasia y su diagnóstico tardío.Cervical cancer is one of the most frequent neoplasms and one of the most common causes of death among women of reproductive age in the world. These figures are paradoxical if we consider that uterine cervix is easily accessible and that there are proven strategies to early diagnosis and effective treatments. In this paper we provide a detailed review of the epidemiology of cervical cancer, with emphasis on related risk factors associated with carcinogenesis and delayed diagnosis.

Ricardo Ortiz Serrano

2004-06-01

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Clinicopathological analysis of 91 cases of uterine cervical cancer (including 38 cases of CIN III)  

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A total of 91 cases of uterine cervical cancer, consisting of 38 cases of carcinoma in situ (CIN III) and 53 cases of stage I-IV cervical cancer, were retrospectively and clinicopathologically analyzed. The standard treatment given to these patients consisted of hysterectomy or conization for CIN III; observation of cases of mild to moderate dysplasia; radical hysterectomy plus pelvic lymph node dissection for stage I and II cervical cancer; and radiotherapy for stage III and IV cervical cancer. Postoperative irradiation consisted of irradiation of the whole pelvis with 40-50 Gy. The patients who were not treated surgically underwent 40 Gy external irradiation of the whole pelvis, followed by an additional 20 Gy with shielding and internal irradiation with an RALS. When lymph node metastasis was present, the nodes were irradiated with 40-50 Gy. The mean age of the 38 patients with CIN III was 45.2 years old, and they were para 0-4. In 24 (63.2%) of them the cancer was detected by cytodiagnosis as part of screening. Radical hysterectomy, simple hysterectomy, and conization were performed in 25 patients, 7 patients, and 6 patients, respectively. No recurrences have been detected, and the survival rate is 100%. The mean age of the 53 patients with cervical cancer stage I-IV was 62.4 years old, and they were para 0-10. There were 25 patients with stage I disease, 15 patients with stage II disease, 6 patients with stage III, and 7 patients with stage IV, and their 5-year survival rate was 82.4%, 68.8%, 66.7%, and 42.9%, respectively. Radioenteritis and radiocystitis occurred as adverse radiation effects. Pathologic factors influencing lymph node metastasis were examined by a multivariate analysis based on the data from 25 patients with stage I and II who underwent hysterectomy. The results of the analysis indicated the importance of screening and the choice of appropriate surgical method/technique, as well as the need for further investigation to determine the effective range of dissection to prevent lymph node metastasis. (K.H.)

Obata, Naoko; Kamiya, Norio [Nagoya Memorial Hospital (Japan); Goto, Setsuko; Takahashi, Satoru

2000-07-01

59

External beam boost irradiation for clinically positive pelvic nodes in patients with uterine cervical cancer  

International Nuclear Information System (INIS)

The purpose of this study was to retrospectively analyze the treatment results of boost external beam radiotherapy (EBRT) to clinically positive pelvic nodes in patients with uterine cervical cancer. The study population comprised 174 patients with International Federation of Gynecology and Obstetrics (FIGO) stages 1B1-4A cervical cancer who were treated with definitive radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT). Patients with positive para-aortic or common iliac nodes (?10 mm in the shortest diameter, as evaluated by CT/MRI) were ineligible for the study. Fifty-seven patients (33%) had clinically positive pelvic nodes. The median maximum diameter of the nodes was 15 mm (range, 10-60 mm) and the median number of positive lymph nodes was two (range, one to four). Fifty-two of 57 patients (91%) with positive nodes were treated with boost EBRT (6-10 Gy in three to five fractions). The median prescribed dose of EBRT for nodes was 56 Gy. The median follow-up time for all patients was 66 months (range, 3-142 months). The 5-year overall survival rate, disease-free survival rate and pelvic control rate for patients with positive and negative nodes were 73% and 92% (P=0.001), 58% and 84% (P<0.001), and 83% and 92% (P=0.082), respectively. Five of 57 node-positive patients (9%) developed pelvic node recurrences. All five patients with nodal failure had concomitant cervical failure and/or distant metastases. No significant difference was observed with respect to the incidence or severity of late complications by application of boost EBRT. The current retrospective study demonstrated that boost EBRT to positive pelvic nodes achieves favorable nodal control without increasing late complications. (author)

60

Diffusion-weighted imaging in predicting and monitoring the response of uterine cervical cancer to combined chemoradiation  

International Nuclear Information System (INIS)

Aim: To investigate the ability of diffusion-weighted imaging (DWI) to predict and monitor the response of uterine cervical cancer to combined chemoradiation using apparent diffusion coefficients (ADCs). Materials and methods: Seventeen women (mean age 48.5 years) with uterine cervical cancer received conventional magnetic resonance imaging (MRI) and DWI prior to chemoradiation and after 1 and 2 months of therapy. A subgroup of eight also had MRI and DWI repeated after 15 days of therapy. Treatment response was determined according to changes in tumour size after 2 months of therapy and was classified as complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD). Pretreatment ADCs were compared between the different disease response groups, and dynamic changes of ADCs in each group were observed. Pearson's correlation test was calculated between those ADC parameters and tumour response. Results: Pretreatment ADCs for CR were significantly lower than those of PR (p = 0.005). Negative correlation was found between pretreatment ADCs and percentage size reduction after 2 months of chemoradiation (p = 0.016). The percentage ADC change after 1 month correlated positively with percentage size reduction after 2 months of therapy (p = 0.021). ADCs after 15 days of therapy increased significantly compared with pretreatment ones (p = 0.001); however, the longest tumour diameter showed no statistically significant change (p = 0.078). Conclusion: ADCs may have the potential to be used to predict and monitor the response of uterine cervical cancer to therapy.

 
 
 
 
61

Changes in Bone Mineral Density in Uterine Cervical Cancer Patients After Radiation Therapy  

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Purpose: To prospectively investigate the changes in bone mineral density (BMD) after pelvic radiation therapy in patients with uterine cervical cancer. Methods and Materials: Of 52 cervical cancer patients who received pelvic RT in our university hospital between 2009 and 2011, 46 patients without recurrence and who were followed up for more than 12 months were included in the study. The BMD of the irradiated region and nonirradiated regions, serum estradiol, tartrate-resistant acid phosphatase-5b, and N-terminal cross-linking telopeptide of collagen 1 were measured before, at 3 months after, and at 12 months after RT. The patient cohort was divided into 2 groups according to estradiol level before RT, and the groups were defined as postmenopausal (<40 pg/mL) and premenopausal (?40 pg/mL). Results: The mean BMDs within the irradiation field (lumbar vertebra 5) in the postmenopausal and the premenopausal groups were 0.825 and 0.910 g/cm{sup 2} before RT and 0.746 and 0.841 g/cm{sup 2} 12 months after RT, respectively. Significant decreases were observed in both groups (P<.05 and P<.01, respectively). In addition, in the premenopausal group the mean BMDs of the nonirradiated regions at thoracic vertebrae 9-12 and lumbar vertebrae 2-4 were 0.753 and 0.958 g/cm{sup 2} before RT and were significantly decreased to 0.706 and 0.921 g/cm{sup 2} 12 months after RT (P<.01 and P<.05, respectively). Estradiol significantly decreased 3 months after RT, whereas tartrate-resistant acid phosphatase-5b and N-terminal cross-linking telopeptide of collagen 1 continued to increase over time in the premenopausal group. Conclusions: A decrease in BMD in the irradiated region after RT was observed within 1 year, regardless of menopausal status. Furthermore, in premenopausal patients, pelvic RT caused a decrease in systemic BMD.

Okonogi, Noriyuki; Saitoh, Jun-ichi; Suzuki, Yoshiyuki, E-mail: syoshi@gunma-u.ac.jp; Noda, Shin-ei; Ohno, Tatsuya; Oike, Takahiro; Ohkubo, Yu; Ando, Ken; Sato, Hiro; Nakano, Takashi

2013-12-01

62

Quantification of the configuration factor in class I and II cavities and simulated cervical erosions  

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The configuration factor of adhesive cavities is defined as the ratio of the restoration's bonded to unbonded (free) surfaces. Such a configuration factor was described, on ideal cavities, as having a potential value in predicting the behaviour of the restoration, because it is related to the restoration's capacity for relieving stress by flow. The aim of this study was to measure the configuration factor value for real Class I and II cavities and simulates cervical erosions prepared in molar...

Macorra Garci?a, Jose? Carlos La; Go?mez Ferna?ndez, Susana

1996-01-01

63

The effect of uterine motion and uterine margins on target and normal tissue doses in intensity modulated radiation therapy of cervical cancer  

International Nuclear Information System (INIS)

In intensity modulated radiation therapy (IMRT) of cervical cancer, uterine motion can be larger than cervix motion, requiring a larger clinical target volume to planning target volume (CTV-to-PTV) margin around the uterine fundus. This work simulates different motion models and margins to estimate the dosimetric consequences. A virtual study used image sets from ten patients. Plans were created with uniform margins of 1 cm (PTVA) and 2.4 cm (PTVC), and a margin tapering from 2.4 cm at the fundus to 1 cm at the cervix (PTVB). Three inter-fraction motion models (MM) were simulated. In MM1, all structures moved with normally distributed rigid body translations. In MM2, CTV motion was progressively magnified as one moved superiorly from the cervix to the fundus. In MM3, both CTV and normal tissue motion were magnified as in MM2, modeling the scenario where normal tissues move into the void left by the mobile uterus. Plans were evaluated using static and percentile DVHs. For a conventional margin (PTVA), quasi-realistic uterine motion (MM3) reduces fundus dose by about 5 Gy and increases normal tissue volumes receiving 30-50 Gy by ?5%. A tapered CTV-to-PTV margin can restore fundus and CTV doses, but will increase normal tissue volumes receiving 30-50 Gy by a further ?5%.

64

The effect of uterine motion and uterine margins on target and normal tissue doses in intensity modulated radiation therapy of cervical cancer  

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In intensity modulated radiation therapy (IMRT) of cervical cancer, uterine motion can be larger than cervix motion, requiring a larger clinical target volume to planning target volume (CTV-to-PTV) margin around the uterine fundus. This work simulates different motion models and margins to estimate the dosimetric consequences. A virtual study used image sets from ten patients. Plans were created with uniform margins of 1 cm (PTV{sub A}) and 2.4 cm (PTV{sub C}), and a margin tapering from 2.4 cm at the fundus to 1 cm at the cervix (PTV{sub B}). Three inter-fraction motion models (MM) were simulated. In MM1, all structures moved with normally distributed rigid body translations. In MM2, CTV motion was progressively magnified as one moved superiorly from the cervix to the fundus. In MM3, both CTV and normal tissue motion were magnified as in MM2, modeling the scenario where normal tissues move into the void left by the mobile uterus. Plans were evaluated using static and percentile DVHs. For a conventional margin (PTV{sub A}), quasi-realistic uterine motion (MM3) reduces fundus dose by about 5 Gy and increases normal tissue volumes receiving 30-50 Gy by {approx}5%. A tapered CTV-to-PTV margin can restore fundus and CTV doses, but will increase normal tissue volumes receiving 30-50 Gy by a further {approx}5%.

Gordon, J J; Weiss, E; Abayomi, O K; Siebers, J V; Dogan, N, E-mail: jjgordon@vcu.edu [Department of Radiation Oncology, Virginia Commonwealth University, PO Box 980058, Richmond, VA 23298 (United States)

2011-05-21

65

Anti-Müllerian hormone in premenopausal women following treatment of uterine cervical cancer.  

Science.gov (United States)

In this longitudinal study we prospectively enrolled 32 premenopausal women (ages 23-44 years) with stage I-III uterine cervical cancer undergoing surgery and/or chemoradiation. Serum levels of anti-Müllerian hormone, follicle-stimulating hormone and estradiol were examined at baseline and 1 year after treatment. As expected, serum anti-Müllerian hormone was undetectable after salpingo-oophorectomy or chemoradiation. After radical hysterectomy and pelvic lymphadenectomy with ovarian preservation serum anti-Müllerian hormone declined from a mean value of 2.0 ± 1.4 ?g/L to 1.1 ± 0.8 ?g/L (p = 0.01), representing a 45% reduction, whereas there was no significant change in serum levels of follicle-stimulating hormone and estradiol. This implies that ovarian function may be affected not only by castrating treatment but also by radical hysterectomy with ovarian preservation. The risk of premature menopause and the potential need of hormone replacement therapy among these women may be overlooked since they no longer menstruate. PMID:24985038

Hallqvist Everhov, Asa; Bergmark, Karin; Smedby, Karin E; Lindén Hirschberg, Angelica; Flöter Rådestad, Angelique

2014-09-01

66

Two cases of pyogenic osteomyelitis of pubic bone after irradiation for cervical carcinoma of the uterine  

International Nuclear Information System (INIS)

Two cases of pyogenic osteomyelitis of pubic bone occurred after irradiation of cervical carcinoma were reported. Case 1: A 69-year-old female received external irradiation of 50 Gy from November 1993 to April 1994 after supravaginal uterine amputation. The left melosalgia and pain at left pubic region appeared from July 1994. On the MRI, bone marrow of the left pubic region showed low brightness by T1 weighted image and equal brightness by T2 weighted image, and the image was enhanced by gadolinium. An abscess in external obturator muscle was suspected. High accumulation was recognized by bone scintigram at the left pubic region. No bacterial infection was recognized. Focus was removed in May 1995. Case 2: A 80-year-old female received external irradiation of 50 Gy and intracavitary irradiation of 30 Gy in May 1992. Pain at left pubic region appeared from June 1993. Dilation of pubic symphysis and osteoclasia of the left pubic bone were detected on the plain radiograph in March 1995. On the MRI, the left pubic bone marrow showed low brightness by T1 weighted image and equal brightness by T2 weighted image, and image was enhanced by gadolinium. An abscess in small pelvic cavity was suspected. Streptococcus agalactae was detected in abscess, and PIPC was administered by drip infusion for five weeks. They are currently alive and doing well about three years later. (K.H.)

67

Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy  

International Nuclear Information System (INIS)

Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of 69 Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

68

The Prevalence and pattern of HPV-16 immunostaining in uterine cervical carcinomas in Ethiopian women: a pilot study  

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Full Text Available INTRODUCTION: Cancer of the cervix uteri is the second most common cancer among women worldwide. The association of human papillomavirus (HPV infection with cervical carcinogenesis is well documented. This is a pilot study aiming to studying the prevalence and the pattern of Human Papilloma Virus Type 16 (HPV16 by immunostaining in the tissues of cervical carcinomas of Ethiopian women. METHODS: 20 specimens of uterine cervical carcinomas were studied histopathologically and immunohistochemically for HPV16. RESULTS: Histologically the specimens were classified as: Ten cases were Non Keratinized Squamous cell carcinoma (NKSCC, six cases were Keratinized Squamous Cell Carcinoma (KSCC and four cases were Adenocarcinoma (ADC. Immunohistochemistry study showed positivity in eleven cases (55%; seven cases (35% were non-keratinized squamous cell carcinoma; three cases (15% were keratinized squamous cell carcinoma and one case (5% belonged to the adenocarcinomas. CONCLUSION: This study reveals a significant detection of HPV in Ethiopian women by the use of advanced techniques such as Immunohistochemistry (IHC. The data of this study suggested that the marked expression of the HPV 16 was in the less differentiated uterine cervix carcinomas

Mona M Rashed

2011-03-01

69

Predictive role of post-treatment [18F]FDG PET/CT in patients with uterine cervical cancer  

International Nuclear Information System (INIS)

Objective: To evaluate the efficacy of post-treatment positron emission tomography (PET)/computed tomography (CT) for identification of tumor recurrence, and to determine whether [18F]fluorodeoxyglucose (FDG) uptake measured as the maximum standardized uptake value (SUVmax) has predictive role regarding survival in patients with uterine cervical cancer. Methods: Medical records from 276 women with uterine cervical cancer who had post-treatment [18F]FDG PET/CT performed were retrospectively reviewed. Results of PET/CT scans were compared with histological or clinical examination. Results: Ninety-five (34.4%) of the 276 patients had documented recurrence by either surgical biopsy or clinical and imaging follow-up. Median duration from treatment to PET/CT scan was 24 months (range, 6–307). The overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of post-treatment PET/CT were 94.7%, 87.8%, 80.4%, 97%, and 90.2%, respectively. The PET/CT scan modified both the diagnostic or treatment plan in 67 patients (24.3%). Patients were divided into two groups according to cut-off SUVmax established on the basis of ROC analysis (<5.25 vs. ?5.25), and there was a significant difference in OS between groups (p = 0.001). In addition, the 5-year progression-free survival (PFS) and OS rates of patients with a negative PET/CT scan for recurrence were significantly better than those with a positive PET/CT (98.62% vs. 17.83%, p < 0.0001 for PFS, 99.31% vs. 85.38%, p = 0.0015 for OS). Conclusion: Post-treatment PET/CT scan is a sensitive and accurate surveillance modality, and provides prognostic information in uterine cervical cancer. Furthermore, it may allow individualization of patient care.

70

Preterm birth due to cervical insufficiency complicated by placenta accreta and postpartum haemorrhage managed by uterine artery embolisation  

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Full Text Available In this report, we present the case of a young woman undergoing her second pregnancy, with early detected shortened cervix resulting in cervical cerclage procedure. At gestational week 24/25, she presented at a hospital with signs of intra-amniotic infection and spontaneous rupture of membranes. This resulted in pathological preterm delivery with massive postpartum bleeding, which was managed by bilateral uterine artery embolization. Reasons for preterm birth and management options are discussed. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 746-748

Elina Tetere

2014-06-01

71

Preoperative [{sup 18}F]FDG PET/CT maximum standardized uptake value predicts recurrence of uterine cervical cancer  

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To determine if preoperative [{sup 18}F]FDG-PET/CT imaging has prognostic significance in patients with uterine cervical cancer. Patients with FIGO stage IB to IIA cervical cancer were imaged with integrated FDG PET/CT before radical surgery. The relationship between the maximum standardized uptake value (SUV{sub max}) of FDG in the primary tumour during PET/CT and recurrence was examined. Included in the study were 75 patients. Medical records including clinical data, treatment modalities, and treatment results were retrospectively reviewed. The median duration of follow-up was 13 months (range 3 to 58 months) after treatment. Median preoperative SUV{sub max} values in the primary tumours were significantly higher in patients with higher FIGO stages (p = 0.0149), pelvic lymph node metastasis (p = 0.0068), parametrial involvement (p = 0.0002), large (>4 cm) tumour size (p = 0.0022), presence of lymphovascular space invasion (p = 0.0055), and deep cervical stromal invasion (p < 0.0001). In univariate analysis, lymph node metastasis, parametrial invasion, presence of lymphovascular space invasion, and preoperative SUV{sub max} (uncategorized values) in the primary tumour were significantly associated with recurrence. However, in multivariate analysis, preoperative SUV{sub max} (p = 0.014, HR 1.178, 95% CI 1.034-1.342), age (p = 0.021, HR 0.87, 95% CI 0.772-0.980), and parametrial involvement (p = 0.040, HR 27.974, 95% CI 1.156-677.043) by primary tumour were significantly associated with recurrence. Preoperative FDG uptake by the primary tumour showed a significant association with recurrence in patients with uterine cervical cancer. (orig.)

Chung, Hyun Hoon; Kim, Jae Weon; Park, Noh-Hyun; Song, Yong-Sang; Kang, Soon-Beom [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea); Nam, Byung-Ho [National Cancer Center, Division of Cancer Epidemiology and Management, Research Institute, Seoul (Korea); Kang, Keon Wook; Chung, June-Key [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul (Korea)

2010-08-15

72

Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino Human papillomavirus genotyping of cervical uterine preneoplastic lesions in a high risk area  

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The relationship between human papillomavirus (HPV) and uterine cervical cancer (UCC) is widely known and accepted. Aim: To determine the frequency of genotypes of HPV in cervical preneoplastic lesions in a high risk area of UCC. Material and Methods: Using a combination of PCR and Reverse Line Blot technique, 235 formalin fixed paraffin embedded samples, with diagnosis of low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (...

Jaime Lo?pez, M.; Carmen Gloria Ili, G.; Priscilla Brebi, M.; Patricia Garci?a, M.; Italo Capurro, V.; Pablo Guzma?n, G.; Eugenio Sua?rez, P.; Jose? Manuel Ojeda, F.; Juan Carlos Roa, S.

2010-01-01

73

Uterine Cancer Statistics  

Science.gov (United States)

... and Badges About the Campaign Buttons and Badges Statistics for Other Types of Cancer Breast Cervical Colorectal ( ... Skin Vaginal and Vulvar Cancer Home Uterine Cancer Statistics Uterine cancer is the fourth most common cancer ...

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Analysis of High Dose Rate Intracavitary Radiotherapy (HDR-ICR) Treatment Planning for Uterine Cervical Cancer  

International Nuclear Information System (INIS)

Purpose: This study was done to confirm the reference point variation according to variation in applicator configuration in each fractionation of HDR ICR. Materials and Methods: We analyzed the treatment planning of HDRICR for 33 uterine cervical cancer patients treated in department of therapeutic radiology from January 1992 to February 1992. Analysis was done with respect to three view points-Interfractionation A point variation, interfractionation bladder and rectum dose ratio validation, interfractionation treatment volume variation. Interfractionation A point variation was defined as difference between maximum and minimum distance from fixed rectal point to A point in each patient. Interfractionation bladder and rectum dose ration variation was defined as difference between maximum and minimum dose ratio of bladder or rectum to A point dose in each patient.. Interfractionation treatment volume variation was defined as difference between maximum and minimum treatment volume which absorbed over the described dose that is, 350 cGy or 400 cGy-in each patient. Results: The mean of distance from rectum to A point was 4.44cm , and the mean of interfractionation distance variation was 1.14cm in right side, 1.09cm in left side. The mean of bladder and rectum dose ratio was 63.8% and 63.1% and the mean of interfractionation variation was 14.9% and 15.8% respectively. With fixed planning administration of same planning to all fractionations as in first fractionation planninonations as in first fractionation planning mean of bladder and rectum dose ration was 64.9% and 72.3% and the mean of interfraction variation was 28.1% and 48.1% respectively. The mean of treatment volume was 84.15cm3 and the interfractionation variation was 21.47 cm3. Conclusion: From these data, it was confirmed that there should be adapted planning for every fractionation, and that confirmation device installed in ICR room would reduce the interfractionation variation due to more stable applicator configuration

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Tumor volume and uterine body invasion assessed by MRI for prediction of outcome in cervical carcinoma treated with concurrent chemotherapy and radiotherapy  

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The aim of this study was to evaluate the prognostic significance of primary tumor volume and uterine body invasion assessed by pre-treatment MRI for uterine cervical cancer patient treated with concurrent chemotherapy and radiotherapy. A retrospective analysis of 106 patients with IB-IIIB cervical carcinoma was performed. Potential prognostic factors were stage, clinical tumor diameter, histology, age, pelvic lymph node, vaginal extension, parametrial invasion, tumor volume and uterine body invasion status. Multivariate analyses were performed to identify the prognostic factor for overall survival (OS) and disease-free survival (DFS). The 5-year OS, DFS rate were 59.7 and 56.6%. Using multivariate analyses, a large tumor volume (?30 ml; P=0.012) and uterine body invasion (P=0.020) and positive pelvic lymph node (LN) enlargement (P=0.040) showed a significantly unfavorable influence on OS. Using these three factors, patients were divided into four subgroups: the OS rates of patients with risk 0 (volume<30 ml, no uterine body invasion, and negative LN), risk 1 (one of these three factors), risk 2 (two of these three factors) and risk 3 (volume?30 ml, uterine body invasion, and positive LN) were 96.3, 77.5, 53.0 and 14.8%, respectively (P<0.0001). Tumor volume and uterine body invasion determined by MRI were significant prognostic factors for patients with cervical carcinoma. Pelvic lymph node enlargement diagnosed by CT also proved to be a significant prognostic factor in OS. Using these three parameters, we devised a practical and effective model to predict OS. (author)

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A Case of Cervical Pregnancy Following Uterine Curettage: The Most Advanced in Iranian Population  

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Full Text Available A case of cervical ectopic pregnancy in a 37 years old woman with history of two previous cesarean sections and one dilatation/curettage. The case was the advanced cervical pregnancy reported in Iran, which diagnosed in 12 week of gestation by MRI and finally treated by hysterectomy.

Zahra Najmi

2011-09-01

77

The study on the immunological effect of Sizofilan combined with radiotherapy in patients with uterine cervical cancer  

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To investigate the immunological effect of Sizofilan (SPG) combined with radiotherapy, we evaluated the immunological parameters in 22 patients with uterine cervical cancer. Twelve patients were treated with SPG combined with radiotherapy (SPG group), and the other ten patients with radiotherapy only (control group). During radiotherapy, the numbers of lymphocyte and CD2 positive cell decreased in the SPG and control groups. After radiotherapy, however, its numbers in the SPG group became significantly higher than in the control group (p<0.05). The number of CD3 positive cell also presented a tendency to increase after radiotherapy in the SPG group. As for CD20 positive cell, its numbers were kept unchanged after radiotherapy in both groups, and no significant difference was observed between them. NK cell activity decreased during radiotherapy in both groups. After radiotherapy, its activity in the SPG group recovered to its pre-value and became significantly higher than that in the control group (p<0.05). SPG did not have any prominent effect on CD4/CD8 ratio. The adverse effect of SPG to liver or kidney function was not observed in our patients. The SCC level in the SPG group decreased rapidly by radiotherapy as well as that in the control group, and no significant difference was observed in SCC levels between them. So it was suggested that SPG did not suppress the cytocidal effect of radiation to cancer cells. Based on these findings, it was concluded that SPG prompted the recovery of not only lymphocyte, especially T cell, but also NK cell activity. These immunological findings presented a usefulness of clinical application of SPG to radiotherapy in patients with uterine cervical cancer. (author)

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Cerebellar metastases in patients with uterine cervical cancer. Two cases reports and review of the literature; Metastases cerebelleuses chez des patientes atteintes d'un cancer du col uterin. A propos de deux cas et revue de la litterature  

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Brain metastases from cervical cancer are extremely rare. We report on two patients who developed cerebellar metastases following uterine cervical cancer. The interval between diagnosis of the primary cancer and diagnosis of brain metastasis was 8 months. The main complaint was symptoms of increased intracranial pressure and cerebellar syndrome. Surgical excision of the brain lesion followed by radiation therapy was performed in the first case. The second patient received palliative radiation therapy. The first patient died 8 months after diagnosis. The second patient is alive 2 months after diagnosis. (authors)

El Omari-Alaoui, H.; Gaye, P.M.; Kebdani, T.; El Ghazi, E.; Benjaafar, N.; Mansouri, A.; Errihani, H.; Kettani, F.; El Ouahabi, A.; El Gueddari, B.K. [Institut National d' Oncologie, Service de Radiotherapie, Rabat (Morocco)

2003-10-01

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Local lymphocytes and nitric oxide synthase in the uterine cervical stroma of patients with grade III cervical intraepithelial neoplasia  

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Full Text Available SciELO Brazil | Language: English Abstract in english OBJECTIVES: Precancerous and cancerous cells can trigger an immune response that may limit tumor development and can be used as a prognostic marker. The aims of the present study were to quantify the presence of B and T lymphocytes, macrophages and cells expressing inducible nitric oxide synthase (i [...] NOS) in the cervical stroma of women with grade III cervical intraepithelial neoplasia (CIN III) or in the intratumoral and peritumoral tissue of women with stage I invasive carcinoma. METHODS: Cervical tissue specimens were obtained from 60 women (20 each from control tissues, CIN III and invasive carcinomas). The average ages in the control, CIN III and invasive groups were 43.9 (± 4.3), 35.5 (± 9.5), and 50 (± 11.2) years, respectively. The specimens were immunohistochemically labeled with antibodies to identify T lymphocytes (CD3), cytotoxic lymphocytes (CD8), B lymphocytes (CD20), macrophages (CD68) and iNOS. We evaluated the markers in the stroma above the squamocolumnar junction (control), at the intraepithelial lesion (CIN cases), and in the nfiltrating tumor. Two independent observers performed the immunohistochemical analysis. RESULTS: T lymphocytes, B lymphocytes, macrophages and iNOS were present more frequently (P

Cléber Sergio da, Silva; Marcia Antoniazi, Michelin; Renata Margarida, Etchebehere; Sheila Jorge, Adad; Eddie Fernando Candido, Murta.

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Adjuvant chemotherapy following concurrent chemoradiotherapy for uterine cervical cancer with lymphadenopathy  

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The present study aimed to retrospectively evaluate the efficacy and toxicities of adjuvant chemotherapy with paclitaxel and carboplatin (TC) following concurrent cisplatin-based chemoradiation (CCRT) in patients with cervical cancer with lymphadenopathy (N1). A total of 37 patients with FIGO stage IB2-IVA cervical carcinoma with N1 (median age 57 years, range 31–74 years) were enrolled. External beam radiation therapy was followed by high-dose-rate brachytherapy. In cases of suspected para...

Abe, Akiko; Furumoto, Hiroyuki; Nishimura, Masato; Irahara, Minoru; Ikushima, Hitoshi

2012-01-01

 
 
 
 
81

Long-term outcomes of intracavitary hyperthermia in combination with radiotherapy for locally advanced uterine cervical cancer  

International Nuclear Information System (INIS)

Objective: To evaluate the long-term clinical efficacy and toxicities of combined intracavitary hyperthermia and radiotherapy for locally advanced uterine cervical cancer. Methods: 310 patients with locally advanced uterine cervical cancer were assigned into intracavitary hyperthermia + radiotherapy group(TRT, 181 patients) and external-beam radiotherapy + traditional intracavitary radiation group (RT,129 patients). The external-beam radiotherapy were given with 60Co ?-ray or 6-8 MV X-ray in traditional fractionation. In TRT group, radiotherapy was 40 Gy using the anterior-posterior pelvic fields and additional 20-25 Gy using the lateral fields. Hyperthermia was delivered by the 915 MHz microwave hyperthermia device within 15-60 min after external radiotherapy for 10-12 times(40 min each time, 1-2 times per week). The temperature of tumor surface was 46-47 degree C. In the RT group, the external-beam radiotherapy of 40 Gy was delivered using the anterior-posterior pelvic fields. The intracavity radiotherapy of radium was delivered before 1989, with 50 mg radium in the vagina and 30 mg in uterine cavity for 24 hours, weekly for 3 times to a total dose of 7200 mg·h. After 1989, intracavity radiotherapy of 192Ir was delivered to a total dose of 30-36 Gy to point A in 5-6 Gy fractions, 2 fractions per week. Results: The 5-year survival of patients in TRT group and RT group was 67.4% versus 52.1% for stage II disease (?2=7.55, P=0.006), and 60.0% versus 32.3% for stage III (?2=7.06, P=0.007). The 10-year survival was 46.5% versus 42.6% for stage II (?2=3.90, P=0.058), and 43.7% versus 20.6% for stage III (?2=17.28, P=0.000). Cox regression analysis showed that the tumor stage(P=0.023) and intracavitary hyperthermia (P=0.019) were prognostic factors. According to the RTOG criteria, the rate of mild to moderate late side effects of rectum and bladder in TRT and RT group was 17.7% and 33.1%, respectively (?2=9.18, P=0.002). Rectovaginal fistula was developed in 5 patients (3.9%) in RT group and 1 patient (0.6%) in TRT group (?2= 4.38,P=0.036). Conclusions: The long-term survival of patients with stage III uterine cervical cancer is better of TRT group than RT group. The TRT is well tolerated and the late toxicity rate is obviously low. it is necessary to carry out large randomized clinical trials to confirm these outcomes. (authors)

82

Metastatic cervical lymphadenopathy from uterine leiomyosarcoma with good local response to radiotherapy and chemotherapy  

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The metastasis of uterine leiomyosarcoma to the neck node has not been reported previously and the radiotherapy has been rarely used for the metastatic lesion of the other sites. We report a case of neck metastasis from a uterine leiomyosarcoma, which developed 10 months after surgery and postoperative pelvic radiotherapy. It also involved the parapharyngeal space, adjacent spine, and spinal canal. The metastatic neck mass was inoperable, and was treated by neck radiotherapy (6,000 cGy) and chemotherapy including taxol and carboplatin. The mass has regressed progressively to a nearly impalpable state. She has never developed spinal cord compression syndrome, and has maintained good swallowing for eight months since the neck radiotherapy and chemotherapy. Since the extensive metastatic neck mass showed good local response to high dose radiotherapy and chemotherapy, both treatments may be considered for an unresectable metastatic leiomyosarcoma

83

Increased activity of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in purified cell suspensions and single cells from the uterine cervix in cervical intraepithelial neoplasia.  

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The activities of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase have been measured in squamous epithelial cells of the uterine cervix from normal patients and cases of cervical intraepithelial neoplasia (CIN). A biochemical cycling method, which uses only simple equipment and is suited to routine use and to automation, was applied to cells separated by gradient centrifugation. In addition, cells were examined cytochemically, and the intensity of staining in the cytopl...

Jonas, S. K.; Benedetto, C.; Flatman, A.; Hammond, R. H.; Micheletti, L.; Riley, C.; Riley, P. A.; Spargo, D. J.; Zonca, M.; Slater, T. F.

1992-01-01

84

The value of prognostic factors for uterine cervical cancer patients treated with irradiation alone  

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Background The aim of our study was to investigate and evaluate the prognostic value of and correlations between preclinical and clinical factors such as the stage of the disease, blood Hb level before treatment, size of cervix and lymph nodes evaluated by CT, age, dose of irradiation and duration of radiotherapy related to overall survival, disease-free survival, local control and metastases-free survival in cervical cancer patients receiving radiotherapy alone. Methods 162 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIA-IIIB cervical carcinoma treated with irradiation were analysed. Univariate and multivariate analyses using the Cox regression model were performed to determine statistical significance of some tumor-related factors. Results The Hb level before treatment showed significant influence on overall survival (p = 0.001), desease free survival (p = 0.040) and local control (p = 0.038). The lymph node status (>10 mm) assessed on CT had impact on overall survival (p = 0,030) and local control (p = 0,036). The dose at point A had impact on disease free survival (p = 0,028) and local control (p = 0,021) and the radiotherapy duration had showed significant influence on overall survival (p = 0,045), disease free survival (p = 0,006) and local control (p = 0,033). Conclusion Anemia is a significant and independent prognostic factor of overall survival, disease-free survival and local control in cervical cancer patients treated with irradiation. The size of lymph nodes in CT is an independent prognostic factor for overall survival and local control in cervical cancer patients. The size of cervix uteri evaluated by CT has no prognostic significance in cervical cancer patients treated with radiotherapy. The prognostic value of FIGO stage of cervical cancer is influenced by other factors, analyzed in this study and is not an independent prognostic factor. PMID:18154683

Grigiene, Ruta; Valuckas, Konstantinas P; Aleknavicius, Eduardas; Kurtinaitis, Juozas; Letautiene, Simona R

2007-01-01

85

The value of prognostic factors for uterine cervical cancer patients treated with irradiation alone  

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Full Text Available Abstract Background The aim of our study was to investigate and evaluate the prognostic value of and correlations between preclinical and clinical factors such as the stage of the disease, blood Hb level before treatment, size of cervix and lymph nodes evaluated by CT, age, dose of irradiation and duration of radiotherapy related to overall survival, disease-free survival, local control and metastases-free survival in cervical cancer patients receiving radiotherapy alone. Methods 162 patients with International Federation of Gynecology and Obstetrics (FIGO stage IIA-IIIB cervical carcinoma treated with irradiation were analysed. Univariate and multivariate analyses using the Cox regression model were performed to determine statistical significance of some tumor-related factors. Results The Hb level before treatment showed significant influence on overall survival (p = 0.001, desease free survival (p = 0.040 and local control (p = 0.038. The lymph node status (>10 mm assessed on CT had impact on overall survival (p = 0,030 and local control (p = 0,036. The dose at point A had impact on disease free survival (p = 0,028 and local control (p = 0,021 and the radiotherapy duration had showed significant influence on overall survival (p = 0,045, disease free survival (p = 0,006 and local control (p = 0,033. Conclusion Anemia is a significant and independent prognostic factor of overall survival, disease-free survival and local control in cervical cancer patients treated with irradiation. The size of lymph nodes in CT is an independent prognostic factor for overall survival and local control in cervical cancer patients. The size of cervix uteri evaluated by CT has no prognostic significance in cervical cancer patients treated with radiotherapy. The prognostic value of FIGO stage of cervical cancer is influenced by other factors, analyzed in this study and is not an independent prognostic factor.

Kurtinaitis Juozas

2007-12-01

86

Apparent rarity of asymptomatic herpes cervicitis in a woman with intra-uterine contraceptive device  

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Full Text Available Infection with genital herpes simplex virus (HSV remains a common viral sexually transmitted disease, often subclinical and a major worldwide problem of women of reproductive age group. Herpes cervicitis is an unusual presentation of Herpes simplex virus infection in females. The finding of herpes cervicitis on routine pap smear of an asymptomatic woman on Intrauterine contraceptive device still further supports the need for increased awareness on the possibility of Herpes simplex virus infection among women, particularly those on Intrauterine contraceptive device. The index case is a 28 years old Nigerian female who was referred to our Special Treatment Clinic on account of an abnormal pap smear cytology which was in keeping with Herpes cervicitis. There was no history of genital ulcer in this patient; however ELISA for HSV 2 IgM was positive in her. We therefore describe a case of herpes cervicitis in an asymptomatic woman on intrauterine contraceptive device. This case highlights to clinicians the need to be aware of the possibility of this association and to carry out relevant investigations so as to identify and treat these patients appropriately. Therefore, there is a need to put in place adequate public health intervention strategy to prevent genital herpes in women of reproductive age group with a view to preventing the possibility of congenital herpes in subsequent pregnancy.

Adeola Fowotade

2013-12-01

87

Chemotherapy in locally advanced cervical cancers; Chimioradiotherapie dans les cancers du col uterin localement evolues  

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The authors report a retrospective analysis of data and results obtained in Morocco in the treatment of 130 locally advanced cervical cancers from January 2005 to June 2008. A majority of patients were treated by chemotherapy in combination with an external radiotherapy. The prognostic remains unfavourable. Short communication

Elkholti, Y.; Rida, H.; Sadek, H.; Erraisse, M.A.; Derhem, N.; Benhmidoune, M.A.; Elomrani, A.; Khouchani, M.; Tahri, A. [service de radiotherapie, CHU Mohammed-VI, Marrakech (Morocco)

2010-10-15

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El cáncer cervicouterino y las lesiones precursoras: revisión bibliográfica / Cervical-uterine cancer and precursor lesions: a literature review  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Con el objetivo de actualizar el estado del arte sobre el cáncer cervicouterino y las lesiones precursoras se realizó una revisión bibliográfica de los artículos publicados en los últimos 5 años, y de otros originales teniendo en cuenta su nivel de evidencia médica I - II. Se utilizaron los buscador [...] es de la biblioteca Cochrane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, J Clinical Oncology, Medscape, PubMed, PubMed Central y artículos de la Agencia Internacional del Cáncer de Francia. Se revisaron los siguientes aspectos: Definiciones, epidemiología, etiología, factores de riesgo, citología, colposcopia, histopatología, clasificaciones, estadios clínicos, tratamientos, prevención, promoción de salud y problemas sociales. El cáncer cervicouterino es una enfermedad prevenible y curable, multifactorial, trasmitida sexualmente por el Virus del Papiloma Humano, con alta incidencia y prevalencia, y a pesar de los programas de pesquisaje continúa siendo un problema de salud. Se necesita de monitoreo permanente del programa de detección precoz en todos los ámbitos y alternativas de pesquisaje, adecuadas localmente a las necesidades, y de fuertes prevención y tratamiento para poder disminuir la carga social y económica que de este problema se derivan. Abstract in english Aimed at knowing the state of the art of cervical-uterine cancer and precursor lesions a literature review was carried out supported on the articles published in the last five years and from other original sources considering the levels I-II of medical evidences. Health information sources from Coch [...] rane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, Journal of Clinical Oncology, Medscape, PubMed, Central PubMed and French International Cancer Agency were used to revise the following aspects: definitions, epidemiology, etiology, risk factors, cytology, colposcopy, histopathology, classifications, clinical stages, treatments, prevention, health promotion and social problems. Cervical-uterine is a preventable, curable and multifactorial disease that is sexually transmitted by Human Papilloma Virus, presenting a high incidence and prevalence. Despite continuing screening programs, it is a health problem. Permanent monitoring programs to the early detection of this entity from all scopes must be carried out, along with screening alternatives that should be adjusted to the local needs, as well as the design of prevention and treatment programs to reduce social and economic burden resulting from this health problem.

José Guillermo, Sanabria Negrín; Zoila C, Fernández Montequín; Inalvis de la Caridad, Cruz Hernández; Leonardo Oriolo, Pérez; Margarita, Llanuch Lara.

2011-12-01

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The effects of PS-K on long-term survival of uterine cervical cancer patients treated with radiation  

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The effects of PS-K on long-term survival of uterine cervical cancer patients treated with radiation was studied. The patients receiving PS-K were anxious about curability more or less at the time of completion of radiation therapy. Between 1977 and 1983, out of 96 patients with stage III, IV uterine cervical cancer treated with radiation, 27 were given PS-K as adjuvant therapy. The number of cases with PS-K administration were 15 (23 %) out of 64 in stage IIIb, seven (37 %) out of 19 in stage IVa and five (38 %) out of 13 in stage IVb. Out of 27 patients administered PS-K, 19 were given the agent within three months after irradiation and the remaining eight after recognition of recurrence or metastasis. As a rule, PS-K was given orally, 3.0 g per day, intermittently in the pattern of two weeks per month. Judgement of the effects of PS-K was made in comparison with the survival rate of the patients with and without PS-K, and then by observation of the changes of the PPD skin test, ESR, appetite and body weight as early effectiveness of PS-K. The results were as follows. 1) Obvious prolongation of survival was recognized in the patients with PS-K after irradiation. Namely, the cumulative five-year survival rates of stage IIIb were 65 % and 49 % with and without PS-K, respectively. 2) Improvement by PS-K as early effectiveness was obtained in seven cases (37 %) out of 19. 3) The conditions necessary for long-term survival with PS-K were thought to be follows: that the tS-K were thought to be follows: that the tumor almost disappears as a result of irradiation and that the condition of the host is superior to that of the tumor in the tumor-host relationship. 4) The effectiveness of intermittent administration of PS-K was suggested. (author)

90

El cáncer cervicouterino y las lesiones precursoras: revisión bibliográfica / Cervical-uterine cancer and precursor lesions: a literature review  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Con el objetivo de actualizar el estado del arte sobre el cáncer cervicouterino y las lesiones precursoras se realizó una revisión bibliográfica de los artículos publicados en los últimos 5 años, y de otros originales teniendo en cuenta su nivel de evidencia médica I - II. Se utilizaron los buscador [...] es de la biblioteca Cochrane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, J Clinical Oncology, Medscape, PubMed, PubMed Central y artículos de la Agencia Internacional del Cáncer de Francia. Se revisaron los siguientes aspectos: Definiciones, epidemiología, etiología, factores de riesgo, citología, colposcopia, histopatología, clasificaciones, estadios clínicos, tratamientos, prevención, promoción de salud y problemas sociales. El cáncer cervicouterino es una enfermedad prevenible y curable, multifactorial, trasmitida sexualmente por el Virus del Papiloma Humano, con alta incidencia y prevalencia, y a pesar de los programas de pesquisaje continúa siendo un problema de salud. Se necesita de monitoreo permanente del programa de detección precoz en todos los ámbitos y alternativas de pesquisaje, adecuadas localmente a las necesidades, y de fuertes prevención y tratamiento para poder disminuir la carga social y económica que de este problema se derivan. Abstract in english Aimed at knowing the state of the art of cervical-uterine cancer and precursor lesions a literature review was carried out supported on the articles published in the last five years and from other original sources considering the levels I-II of medical evidences. Health information sources from Coch [...] rane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, Journal of Clinical Oncology, Medscape, PubMed, Central PubMed and French International Cancer Agency were used to revise the following aspects: definitions, epidemiology, etiology, risk factors, cytology, colposcopy, histopathology, classifications, clinical stages, treatments, prevention, health promotion and social problems. Cervical-uterine is a preventable, curable and multifactorial disease that is sexually transmitted by Human Papilloma Virus, presenting a high incidence and prevalence. Despite continuing screening programs, it is a health problem. Permanent monitoring programs to the early detection of this entity from all scopes must be carried out, along with screening alternatives that should be adjusted to the local needs, as well as the design of prevention and treatment programs to reduce social and economic burden resulting from this health problem.

José Guillermo, Sanabria Negrín; Zoila C, Fernández Montequín; Inalvis de la Caridad, Cruz Hernández; Leonardo Oriolo, Pérez; Margarita, Llanuch Lara.

91

El cáncer cervicouterino y las lesiones precursoras: revisión bibliográfica Cervical-uterine cancer and precursor lesions: a literature review  

Directory of Open Access Journals (Sweden)

Full Text Available Con el objetivo de actualizar el estado del arte sobre el cáncer cervicouterino y las lesiones precursoras se realizó una revisión bibliográfica de los artículos publicados en los últimos 5 años, y de otros originales teniendo en cuenta su nivel de evidencia médica I - II. Se utilizaron los buscadores de la biblioteca Cochrane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, J Clinical Oncology, Medscape, PubMed, PubMed Central y artículos de la Agencia Internacional del Cáncer de Francia. Se revisaron los siguientes aspectos: Definiciones, epidemiología, etiología, factores de riesgo, citología, colposcopia, histopatología, clasificaciones, estadios clínicos, tratamientos, prevención, promoción de salud y problemas sociales. El cáncer cervicouterino es una enfermedad prevenible y curable, multifactorial, trasmitida sexualmente por el Virus del Papiloma Humano, con alta incidencia y prevalencia, y a pesar de los programas de pesquisaje continúa siendo un problema de salud. Se necesita de monitoreo permanente del programa de detección precoz en todos los ámbitos y alternativas de pesquisaje, adecuadas localmente a las necesidades, y de fuertes prevención y tratamiento para poder disminuir la carga social y económica que de este problema se derivan.Aimed at knowing the state of the art of cervical-uterine cancer and precursor lesions a literature review was carried out supported on the articles published in the last five years and from other original sources considering the levels I-II of medical evidences. Health information sources from Cochrane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, Journal of Clinical Oncology, Medscape, PubMed, Central PubMed and French International Cancer Agency were used to revise the following aspects: definitions, epidemiology, etiology, risk factors, cytology, colposcopy, histopathology, classifications, clinical stages, treatments, prevention, health promotion and social problems. Cervical-uterine is a preventable, curable and multifactorial disease that is sexually transmitted by Human Papilloma Virus, presenting a high incidence and prevalence. Despite continuing screening programs, it is a health problem. Permanent monitoring programs to the early detection of this entity from all scopes must be carried out, along with screening alternatives that should be adjusted to the local needs, as well as the design of prevention and treatment programs to reduce social and economic burden resulting from this health problem.

José Guillermo Sanabria Negrín

2011-12-01

92

How do we treat peritoneal lymph nodes in the treatment of uterine cervical cancer?  

International Nuclear Information System (INIS)

During a 8-year period between 1982 and 1989, 759 consecutive patients were treated with surgery and/or radiation therapy (n=493) or radiation therapy alone (n=266) in the Osaka Prefectural Center for Adult Disease. Of them, 51 patients had received paraaortic lymph node (PAN) irradiation. Preliminary data from these 51 patients were analyzed to determine potential candidates for PAN irradiation. Good candidates for PAN irradiation seem to be patients who have the following findings: (1) pelvic lymph node involvement, (2) histologically confirmed invasion to the lymphatic vessel, (3) invasion to the uterine corpus, and (4) PAN enlargement on diagnostic imaging or surgery, or histologically confirmed PAN involvement. (N.K.)

93

The cytoimmunological effect of concomitant use of sizofiran (SPG) on advanced uterine cervical cancer treated with radiation  

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The immunological effect has been studied, using of non-specific immunopotentiator sizofiran (SPG) on the patients with advanced uterine cervical cancer treated with radiation. Ten cases (study group : SPG group) were administered weekly 40 mg of SPG through out the course of radiation and two weekly 40 mg during 12 months after radiotherapy. Nineteen cases (control group) were treated with irradiation alone. The lymphocyte count, the PHA index and the ratio of CD4 cells/CD8 cells were significantly reduced by radiotherapy, being observed the most remarkable decrease at post-radiotherapy. But in SPG group, these decreasing value were significantly smaller than in control group and the value showed a more progressive rise during the 12 month respectively. There was no significant difference in peripheral T lymphocyte ; CD3, CD4, CD8. The NK cytotoxic activity showed a progressive rise during the 12 month period following a minimal change after radiotherapy. These results suggest that the SPG have some enhancing effect on the function of the lymphocytes. (author)

94

A study on nucleic acid synthesis and nuclear chromatin of uterine cervical carcinoma  

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1. Specimens from cervical carcinoma taken prior to radiotherapy showed mean labeling index of 29.9% for 3H-TdR and 63.4% for 3H-UdR, indicating that small cell undifferntiated type carcinoma have relatively prominent activity of nucleic acid synthesis as compared to large cell non-keratinizing or keratinizing type carcinoma. 2. Even with biopsy specimens, chromatin patterns of most unirradiated tumors were predominantly of active type whereas tumors in which degenerative patterns of chromatin predominated were only rarely encountered. Active chromatin patterns were frequently conspicuous in small cell undifferentiated type carcinoma. 3. Both the 3H-TdR and 3H-UdR labeling index of cervical carcinoma decreased following irradiation, the diminution of the former being progressively greater with increasing cumulative dosis of radiation. Small cell undifferentiated type carcinoma showed a more marked diminution of the labeling index than large cell type carcinomas. 4. Degenerative patterns of chromatin increased progressively to become predominant over active patterns, with increasing dose of radiation. This shift to predominance of degenerative patterns was more conspicuous in small cell undifferentiated type carcinoma than in large cell type carcinomas. 5. There was a noticeably close interrelation between the nucleic acid synthesis and the chromatin pattern of cervical carcinoma cells before as well as after irradiation. However, the tumor cell responses to radiation appeared to show a slight time lag between the morphologic aspect, or nucleic acid synthesis, and the morphologic aspect, or chromatin patterns, the former preceding the latter. (J.P.N.)

95

A fusion-based approach for uterine cervical cancer histology image classification  

Science.gov (United States)

Expert pathologists commonly perform visual interpretation of histology slides for cervix tissue abnormality diagnosis. We investigated an automated, localized, fusion-based approach for cervix histology image analysis for squamous epithelium classification into Normal, CIN1, CIN2, and CIN3 grades of cervical intraepithelial neoplasia (CIN). The epithelium image analysis approach includes medial axis determination, vertical segment partitioning as medial axis orthogonal cuts, individual vertical segment feature extraction and classification, and image-based classification using a voting scheme fusing the vertical segment CIN grades. Results using 61 images showed at least 15.5% CIN exact grade classification improvement using the localized vertical segment fusion versus global image features. PMID:24075360

De, Soumya; Stanley, R. Joe; Lu, Cheng; Long, Rodney; Antani, Sameer; Thoma, George; Zuna, Rosemary

2013-01-01

96

Central cervical fibroid mimicking as chronic uterine inversion: a case report  

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Full Text Available Leiomyomas are most common benign gynaecological tumor. Most of the fibroids are situated in the body of the uterus, but only in 1-2% cases, they are confined to cervix. We report a case of 33 years old women, para 2 live 2 diagnosed as myomatous polyp on ultrasound and clinically as chronic inversion of uterus. On surgery, we found it as central cervical fibroid with uterus sitting on the fibroid i.e. lantern on the St. Paul?s. [Int J Reprod Contracept Obstet Gynecol 2013; 2(4.000: 687-688

Swati Singh

2013-08-01

97

A case report with typical acute radiation cystitis by postoperative external irradiation to uterine cervical cancer  

International Nuclear Information System (INIS)

A patient with stage IIb cervical cancer who was treated with radical operation and postoperative external irradiation suffered from typical severe acute radiation cystitis at the radiation dose of 4200 rads. This complication is rare at present. Even though this complication is rare but cannot be completely ruled out, periodic urinalysis is necessary during radiation therapy. It is important to diagnose this complication and stop the radiotherapy as soon as possible. As adrenal cortical hormone is thought to be effective, the administration of it should be recommended. (Kumagai, M.)

98

Analysis of systemic inflammatory response in the carcinogenic process of uterine cervical neoplasia.  

Science.gov (United States)

The inflammatory response is an active process in cervical cancer and may act in the progression and/or regression of the lesion. At the site of inflammation, macrophages and neutrophils are present as well as cytokines such as TNF-? and IFN-?. This study aims to evaluate the inflammatory response levels in women with cervical intraepithelial lesions (CIN) and with squamous cell carcinoma (SCC) of the cervix. Serum samples obtained from women without evidence of disease (n=30), with CIN (n=30) and with SCC of the cervix (n=30) were analyzed for the activities of N-acetylglucosaminidase (NAG) and myeloperoxidase (MPO) by enzymatic assay and the serum levels of TNF-? and IFN-? by ELISA assay. The activities of NAG and MPO and the level of TNF-? were higher in women with CIN compared to the women with SCC. The levels of IFN-? were lower in the group of women with CIN compared to the group with SCC. There was not a significant association between the degree of the CIN and the staging of the SCC of the cervix and the degree of inflammation as assessed by the levels of inflammatory markers. The inflammatory response was inversely correlated with the progression of the carcinogenic process. In the three groups, the control group, women with CIN and women with invasive SCC, there was no association between the degree of preinvasive lesions and staging of the SCC of the cervix. PMID:22004597

Lages, Elisa Lopes e; Belo, Andrezza Vilaça; Andrade, Silvia Passos; Rocha, Monaliza Ângela; de Freitas, Gustavo Ferreira; Lamaita, Rívia Mara; Traiman, Paulo; Silva-Filho, Agnaldo Lopes

2011-10-01

99

Cytotoxic effect and radiation enhancement of artemisinin in uterine cervical carcinoma cell line HeLa  

International Nuclear Information System (INIS)

Objective: To investigate cytotoxic and radiosensitizing effect of Artemisinin on cervical carcinoma cell line HeLa. Methods: In order to measure the optimized effective time, cytotoxic effect of Artemisinin on HeLa cell line was investigated with MTT assay. The radiosensitization effect of different doses and different treatment duration of Artemisinin on HeLa cell line were evaluated by MTT test, the SER is 1.17 and radiosensitizing effect was measured with multi-target single hit model through SER of HeLa cell. Cell cycles in different groups were calculated by flow cytometry. Results: The 50% inhibition concentration of Artemisinin interacted with HeLa cells for 24 h is 600.19 nmol/ml, and for 48 h is 160.71 nmol/ml. The HeLa cells'surival ratio is 93.51%, 91.87%, and 87.28% after adding Atemisinin of 110.69 nmol/ml and 1 Gy radiation exposure. There are three groups: the chemotherapy only group, the radiotherapy only group and the combination group. The result of the cell cycles showed that cells in G2/M period decreased in the combination group. Conclusion: Artemisinin has radiosensitization effect on cervical carcinoma HeLa cells, whichshows dose and time dependent. Artemisinin can inhibit the G2/M block by ionizing radiation. (authors)

100

Patient-tailored conservative surgical treatment of invasive uterine cervical squamous cell carcinoma. A review.  

Science.gov (United States)

The aim of this paper was to review currently available data regarding the results of a more conservative, patient-tailored surgical approach in selected cases of early invasive uterine squamous cell carcinoma (SCC). A PubMed search of investigations in the English language published from January 2000 to September 2012 containing the terms conservative surgery, conservative treatment, trachelectomy, parametrectomy, lymphadenectomy, sentinel lymph node biopsy and fertility sparing surgery in combination with SCC was made. Conization only is optimal for women with stage Ia1 disease mainly in tumors without lymph vascular space involvement (LVSI). In stage Ib1 patients interested to maintain reproductive capacity, vaginal or abdominal radical trachelectomy are the procedures of choice. Patients with small tumors (nodes are at very low risk of parametrial involvement and parametrectomy may be omitted in them. Such patients may benefit from less radical surgery and may be candidates for simple hysterectomy, simple trachelectomy, or conization with pelvic lymphadenectomy. Sentinel lymph node (SLN) biopsy is apparently a good predictor of node metastases and allows the performance of lymphadenectomy only in SLN positive cases. Thus lymphadenectomy may also be omitted in some patients. In young women with locally advanced tumors, neoadjuvant chemotherapy followed by fertility-sparing surgery may also be a feasible treatment. A more conservative, patient-tailored surgical approach in selected cases of early SCC is possible resulting in lower morbidity and preservation of fertility without compromising the outcome. PMID:24051940

Menczer, J

2013-08-01

 
 
 
 
101

Intracavitary radiotherapy with Cf-252 for uterine cervical carcinomas at the Japan Cancer Institute Hospital  

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Cf-252 intracavitary radiotherapy using a specially designed remote afterloading system and treatment facility was performed in patients with stage IIB and IIIB cervical carcinoma. Cf-252 was effective for both squamous cell carcinoma and adenocarcinoma. For stage IIB 7/7 (100%) had local control, 1/7 (14%) injury, and 6/7 (85%) had long term survival NED. For stage IIIB disease 3/11 (27%) had local control and long term survival. With the varying doses and treatment protocols used, complications were noted, mostly recto-sigmoid. Further study of Cf-252 use in cervix cancer and of its effect on the recto-sigmoid mucosa is required. Both local control and long-term survival (--5 year) were obtained using Cf-252 intracavitary therapy.

Fukuda, F.; Masubuchi, K.; Kaneta, K.; Tsuya, A.; Irifune, I.; Onai, Y.

1986-01-01

102

Feasibility study of an alternating schedule of radiotherapy and chemotherapy in advanced uterine cervical carcinoma  

International Nuclear Information System (INIS)

36 patients with advanced cervical carcinoma stage III (24 patients) and stage IV (12 patients) entered a feasibility study of a radiotherapy and chemotherapy combination. The first three chemotherapy courses consisted of cis-platinum alone and were interdigitated with radiotherapy. Six more courses composed of an association of cis-platinum and cyclophosphamide were given after the completion of radiotherapy. Radiotherapy was delivered in two courses of 25 Gy separated by a gap of 2 weeks. The overall 4-year survival rate, cumulative loco-regional failure rate, and cumulative meatstasis rate were respectively 44%, 56% and 30% in stage III and 28%, 83% and 74% in stage IV. The incidence of immediate and late complications was low: no patient had her radiotherapy stopped because of an intolerance and two patients had their chemotherapy stopped because of an haematological intolerance. Only one patient presented a severe late clinical complication (small bowel injury). 29 refs.; 2 figs.; 4 tabs

103

Preoperative PET/CT FDG standardized uptake value of pelvic lymph nodes as a significant prognostic factor in patients with uterine cervical cancer  

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Using integrated PET/CT, we evaluated the prognostic relevance in uterine cervical cancer of preoperative pelvic lymph node (LN) [18F]FDG uptake. Patients with FIGO stage IB to IIA uterine cervical cancer were imaged with FDG PET/CT before radical surgery. We used Cox proportional hazards regression to examine the relationship between recurrence and the FDG maximum standardized uptake value (SUVmax) in the pelvic LN (SUVLN) on PET/CT. Clinical data, treatment modalities, and results in 130 eligible patients were reviewed. The median postsurgical follow-up was 34 months (range 6 to 109 months). Receiver operating characteristic analysis identified SUVLN 2.36 as the most significant cut-off value for predicting recurrence. SUVLN was correlated with SUVtumour (P = 0.002), primary tumour size (P = 0.004), and parametrial invasion (P = 0.013). Univariate analyses showed significant associations between recurrence and SUVLN (P = 0.001), SUVtumour (P = 0.007), pelvic LN metastasis (P = 0.002), parametrial invasion (P LN (P = 0.013, hazard ratio, HR, 4.447, 95 % confidence interval, CI, 1.379 - 14.343) and parametrial invasion (P = 0.013, HR 6.728, 95 % CI 1.497 - 30.235) as independent risk factors for recurrence. Patients with SUVLN ?2.36 and SUVLN <2.36 differed significantly in terms of recurrence (HR 15.20, P < 0.001). Preoperative pelvic LN FDG uptake showed a strong significant association with uterine cervical cancer recurrence. (orig.)

104

Pre-treatment diffusion-weighted MR imaging for predicting tumor recurrence in uterine cervical cancer treated with concurrent chemoradiation: Value of histogram analysis of apparent diffusion coefficients  

International Nuclear Information System (INIS)

To evaluate the value of apparent diffusion coefficient (ADC) histogram analysis for predicting tumor recurrence in patients with uterine cervical cancer treated with chemoradiation therapy (CRT). Our institutional review board approved this retrospective study and waived informed consent from each patient. Forty-two patients (mean age, 56 ± 14 years) with biopsy-proven uterine cervical squamous cell carcinoma who underwent both pre-treatment pelvic magnetic resonance imaging with a 3.0 T magnetic resonance scanner and concurrent CRT were included. All patients were followed-up for more than 6 months (mean, 36.4 ± 11.9 months; range 9.0-52.8 months) after completion of CRT. Baseline ADC parameters (mean ADC, 25th percentile, 50th percentile, and 75th percentile ADC values) of tumors were calculated and compared between the recurrence and no recurrence groups. In the recurrence group, the mean ADC and 75th percentile ADC values of tumors were significantly higher than those of the no recurrence group (p = 0.043 and p = 0.008, respectively). In multivariate analysis, the 75th percentile ADC value of tumors was a significant predictor for tumor recurrence (p = 0.009; hazard ratio, 1.319). When the cut-off value of the 75th percentile ADC (0.936 x 10-3 mm2/sec) was used, the overall recurrence free survival rate above the cut-off value was significantly lower than that below the cut-off value (51.9% vs. 91.7%, p = 0.003, log-rank test). Pre-CRT ADC histogram analysis may serve as a biomarker for predicting tumor recurrence in patients with uterine cervical cancer treated with CRT.

105

Preoperative PET/CT FDG standardized uptake value of pelvic lymph nodes as a significant prognostic factor in patients with uterine cervical cancer  

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Using integrated PET/CT, we evaluated the prognostic relevance in uterine cervical cancer of preoperative pelvic lymph node (LN) [{sup 18}F]FDG uptake. Patients with FIGO stage IB to IIA uterine cervical cancer were imaged with FDG PET/CT before radical surgery. We used Cox proportional hazards regression to examine the relationship between recurrence and the FDG maximum standardized uptake value (SUV{sub max}) in the pelvic LN (SUV{sub LN}) on PET/CT. Clinical data, treatment modalities, and results in 130 eligible patients were reviewed. The median postsurgical follow-up was 34 months (range 6 to 109 months). Receiver operating characteristic analysis identified SUV{sub LN} 2.36 as the most significant cut-off value for predicting recurrence. SUV{sub LN} was correlated with SUV{sub tumour} (P = 0.002), primary tumour size (P = 0.004), and parametrial invasion (P = 0.013). Univariate analyses showed significant associations between recurrence and SUV{sub LN} (P = 0.001), SUV{sub tumour} (P = 0.007), pelvic LN metastasis (P = 0.002), parametrial invasion (P < 0.001), primary tumour size (P = 0.007), suspected LN metastasis on MRI (P = 0.024), and FIGO stage (P = 0.026). Multivariate analysis identified SUV{sub LN} (P = 0.013, hazard ratio, HR, 4.447, 95 % confidence interval, CI, 1.379 - 14.343) and parametrial invasion (P = 0.013, HR 6.728, 95 % CI 1.497 - 30.235) as independent risk factors for recurrence. Patients with SUV{sub LN} ?2.36 and SUV{sub LN} <2.36 differed significantly in terms of recurrence (HR 15.20, P < 0.001). Preoperative pelvic LN FDG uptake showed a strong significant association with uterine cervical cancer recurrence. (orig.)

Chung, Hyun Hoon [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea, Republic of); Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Seoul (Korea, Republic of); Cheon, Gi Jeong; Kang, Keon Wook [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul (Korea, Republic of); Kim, Jae Weon; Park, Noh-Hyun [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea, Republic of); Song, Yong Sang [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea, Republic of); Seoul National University, WCU Biomodulation Major, Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul (Korea, Republic of)

2014-04-15

106

Image-Guided Stereotactic Body Radiation Therapy in Patients With Isolated Para-Aortic Lymph Node Metastases From Uterine Cervical and Corpus Cancer  

International Nuclear Information System (INIS)

Purpose: The aims of this study were to evaluate the role of stereotactic body radiation therapy (SBRT) as a local treatment for isolated para-aortic lymph node (PALN) metastases originating from uterine cervical and corpus cancer. Methods and Materials: We retrospectively enrolled 30 patients with isolated PALN metastases originating from uterine cervical and corpus cancer who had received SBRT using the CyberKnife (CK). All patients were shown to have isolated PALN metastases by computed tomography (CT) and/or positron emission tomography (PET)-CT. The overall survival (OS), local control (LC) rate, and disease progression-free survival (DPFS) rate were calculated according to the Kaplan-Meier method. Comparison between prognosis groups was performed using log-rank analysis. Toxicities were also evaluated. Results: The 4-year OS rate was 50.1%, and the median survival time was not reached. The OS rate among symptomatic patients was significantly lower than that among asymptomatic patients (p = 0.002). The 4-year actuarial LC rate was 67.4%. Patients with a planning target volume of ?17 ml had significantly higher LC rates (p = 0.009). The 4-year DPFS rate was 45.0%, and the median time to disease progression was 32 months. Small planning target volume was a favorable prognostic factor (p = 0.043). Grade 3 or 4 complications requiring hospitalization were reported in 1 patient at 20 months after SBRT. Conclusion: The OS and LS rates were promising, and the incidencS rates were promising, and the incidence of toxicities was low. Use of SBRT with the CyberKnife is an effective modality for treating isolated PALN metastases in patients with uterine cervical and corpus cancer.

107

Do clinicians and patients agree regarding symptoms? A comparison after definitive radiochemotherapy in 223 uterine cervical cancer patients  

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Background: In clinical cancer research of morbidity, low associations between clinician-assessed toxicity/morbidity and patient-reported symptoms are consistently described in the literature. While morbidity grading systems are supposed to follow more or less objective criteria, patient reported symptoms inherently are based on a subjective self-evaluation of the impact on quality of life. The aim of this study was to focus on major discrepancies with high clinical relevance and to evaluate its impact with regard to underreporting of morbidity. Material and methods: Early morbidity assessed by clinicians with CTCAEv.3 and patient reported quality of life (EORTC-QLQ-C30/CX24) were compared regarding 12 overlapping symptoms in 223 patients with uterine cervical cancer 3 months after definitive radio(chemo)therapy in the ongoing EMBRACE study. Mismatches showing discrepancies between both grading systems were classified, if patients reported substantial symptoms (quite a bit/very much) and CTCAE grading was rated G0. Results: In total, 360 substantial symptoms were reported by patients by EORTC-QLQ; 159 (44%) of those were not recognized by CTCAE. Symptoms with the highest occurrence of mismatches overall are urinary frequency, fatigue, and insomnia. Large institutional differences were found, showing two centers with 4 vs. 71% of patients with at least one mismatch. Conclusion: Analysis of mismatches indicated a high risk of underestimation of early morbidity. Thus, nearly half of the patient-reported substantial symptoms were not recognized by CTCAE scoring (G0) 3 months after treatment. Prospective assessment of morbidity in clinical studies should, therefore, integrate patient reported symptoms to receive a complete and comprehensive picture. (orig.)

Kirchheiner, K.; Poetter, R. [Medical Univ. Vienna (Austria). Dept. of Radiotherapy; Nout, R. [University Medical Center Leiden (Netherlands). Dept. of Clinical Oncology; Lindegaard, J. [University Hospital Aarhus (Denmark). Dept. of Oncology; Petric, P. [Institute of Oncology Ljubljana (Slovenia). Dept. of Radiotherapy; Limbergen, E.V. [University Hospital Leuven (Belgium). Dept. of Radiotherapy; Juergenliemk-Schulz, I.M. [University Medical Center Utrecht (Netherlands). Dept. of Radiation Oncology; Haie-Meder, C. [Institut Gustave-Roussy, Villejuif (France). Dept. of Radiotherapy; Doerr, W. [Technische Univ. Dresden (Germany). Dept. of Radiotherapy and Radiooncology

2012-10-15

108

Interfractional change of high-risk CTV D90 during image-guided brachytherapy for uterine cervical cancer  

International Nuclear Information System (INIS)

The purpose of this study was to evaluate interfractional changes of the minimum dose delivered to 90% of the high-risk clinical target volume (HR-CTV D90) and D2cc of the bladder and rectum during brachytherapy for uterine cervical cancer patients. A total of 52 patients received external beam radiotherapy and high-dose-rate intracavitary brachytherapy (ICBT). For each of four ICBT applications, a pelvic CT scan was performed and the HR-CTV was delineated. Retrospectively, these patients were divided into two groups: (1) the standard dose group with 6 Gy to point A in each ICBT, and (2) the adaptive dose group with a modified dose to point A to cover the HR-CTV with the 6-Gy isodose line as much as possible. The HR-CTV D90 was assessed in every session, and analyzed as interfractional changes. In the standard dose group, the interfractional changes of the HR-CTV D90 showed a linear increase from the first to the third of the four ICBT (average 6.1, 6.6, 7.0 and 7.1 Gy, respectively). In contrast, those of the adaptive dose group remained almost constant (average 7.2, 7.2, 7.3 and 7.4 Gy, respectively). Especially, in the case of a large HR-CTV volume (?35 cm3) at first ICBT, the total HR-CTV D90 of the adaptive dose group with brachytherapy was significantly higher than that of the standard dose group. There were no significant differences in total D2cc in bladder and rectum between the two groups. Image-guided adaptive brachytherapy based on interfractional tumor volume change improves the dose to the HR-CTV while keeping rectal and bladder doses within acceptable levels. (author)

109

Reporting radiotherapeutic complications in patients with uterine cervical cancer. The importance of latency and classification system  

DEFF Research Database (Denmark)

Radiotherapeutic morbidity is reported according to our own system (AADK) and the Franco-Italian glossary (FI) in 442 patients with cervical cancer FIGO stage IIB (139), IIIA (10), IIIB (221), and IVA (72). The AADK system records each symptom, date of appearance, the required therapy, and its initial date. FI describes the maximal damage in 4 grades. Actuarial estimates of moderate or worse complications in the rectosigmoideum differed significantly in relation to stage, while frequencies did not differ. Frequencies were up to 25% lower than the actuarial estimates. Moderate AADK complications in the rectosigmoideum occurred from 1 to more than 24 months in 42% of stage IIIB patients finally developing severe FI complications, and during more than 2 years in 24% of the patients dying from rectosigmoid complications. An analysis of the probability of being alive without moderate or worse AADK complications indicated that survival and complications were unrelated. It is concluded that, with any classification system for reporting morbidity, each symptom and required therapy used in the definition of each complication grade and the date of appearance should be registered regularly to allow (1) reporting of the real risk of organ damage, (2) rescoring of complication grades, (3) separation of early and late morbidity, and (4) reporting of actuarial estimates. If these minimum requirements are met, underestimation of morbidity is avoided.

Pedersen, D; Bentzen, SØren M

1993-01-01

110

Inappropriate cervical injection of radiotracer for sentinel node mapping in a uterine cervix cancer patient: importance of lymphoscintigraphy and blue dye injection  

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Full Text Available Herein, we report a case of sentinel lymph node mapping in a uterine cervix cancer patient, referring to the nuclear medicine department of our institute. Lymphoscintigraphy images showed inappropriate intra?cervical injection of radiotracer. Blue dye technique was applied for sentinel lymph node mapping, using intra?cervical injection of methylene blue. Two blue/cold sentinel lymph nodes, with no pathological involvement, were intra?operatively identified, and the patient was spared pelvic lymph node dissection. The present case underscores the importance of lymphoscintigraphy imaging in sentinel lymph node mapping and demonstrates the added value of blue dye injection in selected patients. It is suggested that preoperative lymphoscintigraphy imaging be considered as an integral part of sentinel lymph node mapping in surgical oncology. Detailed results of lymphoscintigraphy images should be provided for surgeons prior to surgery, and in case the sentinel lymph nodes are not visualized, use of blue dye for sentinel node mapping should be encouraged.

Sima Kadkhodayan

2014-10-01

111

Transition of Ki-67 index of uterine cervical tumors during radiation therapy. Immunohistochemical study  

International Nuclear Information System (INIS)

Histopathologic and Ki-67-staining features of cancer cells were investigated in biopsy specimens before and during radiation therapy in 29 patients with cervical squamous cell carcinoma. No morphologic changes were observed up to doses of 540 cGy. A few intact cancer cells remained up to doses of 2700 cGy. Moderate changes in the cancer cells were noticed in patients who received 900 cGy or more, i.e., multinuclei, swollen nuclei and cytoplasms, and prominent large nucleoli. At doses of 1800 cGy or greater, many cancer nests had severely damaged cancer cells with features such as cytolysis, karyolysis, karyorrhexis, pyknosis, and bizarre giant cells. There was no mitosis in the cells of patients who received doses greater than 1800 cGy. The Ki-67-positive cancer cells showed diffuse nuclear-stainings and dot-stainings before radiation therapy. Radiation doses more than 900 cGy changed the staining pattern of the Ki-67 antibody; large irregular spot-stainings and ring-stainings were observed predominantly. The Ki-67 index initially increased with the radiation dose; the mean Ki-67 indices before radiation therapy and at radiation doses of 180 cGy, 540 cGy, and 900 cGy were 41%, 50%, 63%, and 68%, respectively. The indices decreased when the dose was increased further, and they were 39% and 20% at doses of 1800 cGy and 2700 cGy, respectively. Possible explanations, including recruitment of quiescent cells, for the change in Ki-67 staining are discussed67 staining are discussed

112

Mitomycin-C/5-FU and radiation therapy for locally advanced uterine cervical cancer.  

Science.gov (United States)

To assess the feasibility and effectiveness of combined therapy on locally advanced cervical cancer, we entered 38 patients into a study. The patients were treated with mitomycin-C (10 mg/m2) on Days 1 and 30 and 5-FU (1000 mg/m2) on Days 1 to 4 and Days 30 to 33. In 5 weeks 4500-5000 cGy was given concurrently, followed by radioactive implants. Twenty-six patients had an early-stage disease (IB-IIB) and twelve had a late-stage disease (IIIB-IVA). Eighty-seven percent (33/38) of the patients had a tumor measuring 5 cm or more. The other 5 patients with a tumor size under 5 cm had biopsy-proven positive pelvic nodes; 2 of these 5 patients had a pretherapy hysterectomy. Tumor response, complete (CR) vs partial (PR), was assessed in 36 patients 3 months after completion of therapy. A CR was noted in 80% (29/36) of the patients. The PR status conferred a detrimental effect on the pelvic disease control (PDC), disease-free survival (DFS), and survival (S) while late stage correlated with the development of distant metastases (DM) and a poor DFS. PDC was obtained in 93% (27/29) of the patients who had a CR, as compared to only 43% (3/7) of those with a PR (P = 0.0228). The DFS and S rates were 59 and 77% for patients with a CR and 21 and 19% for those with a PR; respective P values were 0.0340 and 0.0002. Eleven percent (3/26) of the patients with an early stage developed DM, as compared to 50% (6/12) of those with late stage, (P = 0.0016). The DFS rates were 80 and 37% for patients with an early and late stage, respectively (P = 0.0141). Four patients developed transient neutropenia and one had transient thrombocytopenia. The second dose of mitomycin-C was omitted in 4 patients due to persistent neutropenia in 3 and to transfusion-related hepatitis in 1. Two percent (5/21) of the patients who had a staging laparotomy developed wound dehiscence. Three patients developed non-cancer-related small bowel obstruction requiring surgery. We concluded that this combined regimen was well tolerated. Although it was effective in controlling the cancer in the pelvis, this regimen failed to control DM in late-stage patients. PMID:1752491

Nguyen, P D; John, B; Munoz, A K; Yazigi, R; Graham, M; Franklin, P

1991-12-01

113

Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile Detection and genotyping of human papillomavirus in biopsies of uterine cervical adenocarcinoma  

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Background: The genotyping of Human Papillomavirus (HPV) will improve knowledge about the local epidemiological association of this virus with adenocarcinoma. Aim: To determine the frequency of HPV genotypes in biopsies of women with uterine cervical adenocarcinoma in a geographic region of Chile. Materials and Methods: Forty-one cervical biopsies with a pathological diagnosis of adenocarcinoma, corresponding to all women diagnosed with this cancer between 2002 and 20...

Priscilla Brebi M; Carmen Gloria Ili G; Jaime López M; Patricia García M; Angélica Melo A; Sonia Montenegro H; Pamela Leal R; Pablo Guzmán G; Juan Carlos Roa S.

2009-01-01

114

Flow-microfluorometric studies on the effect of misonidazole as a radiosensitizer for human uterine cervical carcinoma transplanted to nude mice  

International Nuclear Information System (INIS)

It is already known that Misonidazole as a radiosensitizer is not so effective with the small doses of radiation that we generally use to treat human uterine cervical carcinoma by fractionated irradiation. Using nude mice in which human uterine cervical carcinoma was transplanted, we examined DNA distribution by Flow-Microfluorometry, nuclear area and growth curves with 1,000 rads single dose irradiation, equally fractionated irradiation (250 rads/day for 4 days) and unequally fractionated irradiation (250 rads/day for 4 days, 500 rads for 1 day) after administration of Misonidazole. It was recognized that repopulation was delayed with 1,000 rads single dose irradiation with Misonidazole lmg/g.b.w. since a reduction in the rate of increase in G2-M cells and an increase in debris lasted a long time in DNA distribution, and the tumor regrowth time was delayed when compared to the only irradiation group. These changes were not observed with equally fractionated irradiation with Misonidazole 0.25mg/g.b.w./day administration, but were significantly observed with unequally fractionated irradiation with Misonidazole lmg/g.b.w. at 500 rads irradiation where the nuclear area was also reduced. As mentioned above, it can be considered that the clinical effect of Misonidazole can be expected as in the case of unequally fractionated irradiation. (author)

115

Postradiation sarcomas of the pelvis after treatment for uterine cervical cancer: review of the CT and MR findings of five cases  

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Objective. To characterize the radiologic features of postradiation sarcomas arising in the pelvic bones following treatment for uterine cervical carcinoma. Design and patients. Five patients who developed postradiation sarcomas in the pelvic bones following radiation therapy for carcinoma of the uterine cervix within the irradiated field were evaluated. Pelvic radiographs, computed tomography (CT) and magnetic resonance (MR) imaging were undertaken in all patients. Histologic confirmation of the tumor type was obtained. Results. Three patients whose tumors were characterized as an osteosarcoma, an angiosarcoma and a malignant fibrous histiocytoma (MFH) showed a large round or oval mass mainly in the sacroiliac joint which extended into the posterior gluteal soft tissues. In a fourth patient an osteosarcoma developed in the central ilium extending widely into the soft tissues both anteriorly and posteriorly, with calcified areas within the extraosseous mass. The fifth patient had a MFH which showed osteolytic destruction of the cortex of the acetabulum, and minimal soft tissue extension. There were no specific features or signal intensity changes on MR imaging to differentiate these cases from primary sarcomas. Conclusion. Postradiation sarcoma must be considered in patients with uterine carcinoma when a soft tissue mass is seen in the previously irradiated field, especially if the mass is posterior to the sacroiliac joint and the latent period is more than 5 years. (orig.)

Nakanishi, Katsuyuki [Osaka Seamen' s Insurance Hospital (Japan). Dept. of Radiology; Yoshikawa, Hideki [Osaka Univ. Medical School (Japan). Dept. of Orthopaedic Surgery; Ueda, Takafumi; Araki, Nobuhito [Osaka Medical Center for Cancer and Cardiovascular Diseases (Japan). Dept. of Orthopaedic Surgery; Tanaka, Hisashi; Nakamura, Hironobu [Osaka Univ. Medical School (Japan). Dept. of Radiology; Aozasa, Katsuyuki [Osaka Medical School (Japan). Dept. of Pathology

2001-03-01

116

Vírus HPV e câncer de colo de útero Virus HPV y el cáncer del cuello uterino Human Papillomavirus (HPV and uterine cervical cancer  

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Full Text Available Este artigo refere-se a uma revisão de literatura sobre o vírus HPV e câncer de colo de útero, com o objetivo de levantar aspectos da infecção do vírus que influenciam no curso natural do câncer de colo de útero tais como: a tipologia do vírus, a duração e a persistência da infecção além de associar com as manifestações das lesões precursoras até a evolução da neoplasia. Foi possível constatar a forte associação da infecção com a evolução da neoplasia cervical, no entanto, ainda são necessários estudos que elucidem melhor certos aspectos da infecção do vírus HPV que agem sobre o colo do útero para que as ações de prevenção e combate a doença sejam mais eficazes.Este artículo se refiere a una revisión de literatura sobre el virus HPV y la neoplasia cervical, con el objetivo de levantar aspectos de la infección del virus que influye en el curso natural del cáncer de cuello del útero tales como: la tipologia del virus, la duración y la persistencia de la infección además de asociarlo a las manifestaciones de las lesiones precursoras hasta la evolución de la neoplasia. Ha sido posible constatar la fuerte asosiación de la infección con la evolución de la neoplasia cervical, entretanto, aún son necesarios estudios que eluciden mejor ciertos aspectos de la infección del virus HPV que actúa sobre el cuello del útero para que las acciones de prevención y combate a la enfermedad sean más eficaces.This article refers to a review of literature about the HPV virus and the cervical neoplasia, aiming at raising aspects of the virus infection which influences in the natural development of the uterine cervical cancer such as: the type of virus, the duration and the persistence of the infection and also the association with the manifestations of the preceding lesions up to the evolution of the neoplasia. It was possible to notice the strong association of the infection with the evolution of the cervical neoplasia, however, studies to better elucidate certain aspects of the infection of the HPV virus that acts on the uterine cervix are still necessary so that the actions of prevention and fight against the disease will be more efficient.

Janete Tamani Tomiyoshi Nakagawa

2010-04-01

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Therapeutic comparison of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages I b2-II a cervical cancer  

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Objective: To compare the short-term and long-term therapeutic response of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages I b2-II a cervical cancer. Methods: One hundred and fifty-one patients with stages I b2-II a cervical cancer were treated with preoperative intra-arterial chemotherapy before radical hysterectomy was carried out. Patients in study group (n = 113) received uterine artery chemoembolization (UACE), while patients control group(n = 38) received internal iliac anterior trunk arterial chemotherapy. Radical hysterectomy was carried out in all patients within 2-4 weeks after UACE or chemotherapy. The tumor size was measured before and after the procedure,and the survival rate at 2 and 5 years after treatment was calculated. Results: The mean maximum diameter of the tumors was (4.58 ± 0.37) cm before interventional therapy, and it was (2.11 ± 0.24) cm in two weeks after interventional therapy. The complete response rate of study group and control group was 31.9% and 21.1% respectively. The total effective rate of study group and control group was 94.7% (107/113) and 76.3% (29/38) respectively. The effective rate of study group two weeks after therapy was significantly higher than that of control group. No surgical margin infiltration was observed in both groups. Pathological findings in study group included vascular invasion around surgical margin (n =lar invasion around surgical margin (n = 3), parametrial invasion (n = 5) and pelvic lymph node metastasis (n = 6), while in control group vascular invasion around surgical margin, parametrial invasion and pelvic lymph node metastasis were found in one, two and one cases respectively. The two-year and five-year survival rate in study group were 80.9% (68/84) and 73.4% (47/64) respectively, while the two-year and five-year survival rate in control group were 81.3% (26/32) and 75.0% (18/24) respectively. No significant difference in survival rate existed between two groups. Conclusion: Uterine artery chemoembolization can markedly reduce the volume of cervical cancer,which is very helpful for surgical resection. The therapeutic effectiveness of UACE is superior to internal iliac anterior trunk arterial chemotherapy, therefore, UACE should be regarded as neo-adjuvant intra-arterial chemotherapy of first choice for patients with stages I b2-II a cervical cancer. (authors)

118

In 252Cf neutron brachytherapy for uterine cervical cancer: the comparison of absorbed dose at anterior rectal wall with shielding by barium enema or lead marker  

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Objective: To show the relation between radiation proctitis and maximum absorbed dose at anterior rectal wall in 252 Californium (252Cf) neutron brachytherapy for uterine cervical cancer. Methods: The absorbed dose at anterior rectal wall of 30 patients was evaluated with shielding by barium enema or lead marker, 15 in each group. Perpendicular isocenter films were taken with the barium or lead marker in place. The dose given at reference point A was 10 Gy. The maximum absorbed dose (Dmax) of anterior rectal wall, posterior bladder wall and the rectal reference point as proposed by ICRU Report 38 were calculated; The distance between the Dmax point at anterior rectal wall, posterior bladder wall and the center of uterine tube were measured by 252Cf neutron after-loading treatment planning system. Radiation proctitis were analyzed both in the whole group and in patients whose absorbed dose of anterior rectal wall was > 4 Gy. Results: The Dmax at anterior rectal wall evaluated by barium enema was significantly higher than those by lead marker. The distance between the Dmax point at anterior rectal wall and the center of uterine tube was significantly lower by barium enema than those by lead marker. The dose of Dmax point at posterior bladder wall, the distance between the Dmax point at posterior bladder wall and the center of uterine tube in these two groups were not significantly different. The morbidity of acute radiation proctitis in patients whose Dmax of anterior rectal wall >4 Gy were significantly higher than in those < 4 Gy patients. Conclusions: Barium enema, being able to show better the anatomic relation between cervix, vagina and anterior rectal wall than lead marker, is able to reflect the real absorbed dose at the anterior rectal wall more accurately, Acute radiation proctitis can be predicted according to Dmax at anterior rectal wall. Moreover, the variation of sigmoid position can also be detected by barium enema at the same time. (authors)

119

Glutathione S-transferase T1 and M1 polymorphisms and risk of uterine cervical lesions in women from central Serbia.  

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The aim of this study was to investigate the frequencies of GSTT1 and GSTM1 deletion polymorphisms in newly-diagnosed patients with uterine cervical lesions from central Serbia. Polymorphisms of GST genes were genotyped in 97 patients with cervical lesions and 50 healthy women using a multiplex polymerase chain reaction (PCR). The GSTM1 null genotype was significantly more prominent among the patients than in controls (74.2% vs 56.0%), the risk associated with lesions being almost 2.3-fold increased (OR=2.26, 95%CI=1.10-4.65, p=0.03) and 3.17-fold higher in patients above >45 years old (95%CI=1.02-9.79, p=0.04). The analysis of the two genotypes demonstrated that GSTM1 null genotype significantly increased risk only for low grade squamous intraepithelial lesion-LSIL (OR=2.81, 95%CI=1.03-7.68, p=0.04). GSTT1 null genotype or different genotype combinations were not found to be risk factors, irrespective to lesion stages, age or smoking. We found that the risk of cervical lesions might be significantly related to the GSTM1 null genotype, especially in women aged above 45 years. Furthermore, the GSTM1 polymorphism might have greater role in development of early stage lesions. PMID:24815471

Stosic, Ivana; Grujicic, Darko; Arsenijevic, Slobodan; Brkic, Marija; Milosevic-Djordjevic, Olivera

2014-01-01

120

Cervicitis  

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... into the pelvic area such as a cervical cap, diaphragm, or pessary Allergy to spermicides used for ... does not go away: Discharge may be gray, white or yellow in color Painful sexual intercourse Pain ...

 
 
 
 
121

Japanese patterns of care study of postoperative radiotherapy for uterine cervical cancer. The assessment of treatment process of the 1995-2005 surveys  

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The purpose of the study is to evaluate Japanese national practice patterns for patients undergoing postoperative radiotherapy for uterine cervical cancer. The Japan Patterns of Care Study (JPCS) collected the data of patients who were treated postoperative radiation therapy between 1995-1997 (JPCS 95-97), 1999-2001 (JPCS 99-01) and 2003-2005 (JPCS 03-05). Over 80% of patients were treated with external beam RT (ERT). ERT dose ranged from 45 to 50.4 Gy for over 70% of patients. The utilization rates of CT-simulation, multi-leaf collimator and over 10 MV photon energy were increased among three JPCS surveys. Positive lymph nodes, capillary lymphatic space tumor involvement and deep stromal invasion was the main reasons of adaptation of the postoperative radiotherapy. Compared with the previous 2 PCS studies, the patient who received concurrent chemoradiation was increased in JPCS 03-05 (6, 9% to 25%). (author)

122

Increase in rectal dose by variance in administration of Fletcher-Suit applicator during intracavitary high dose rate brachytherapy for uterine cervical cancer  

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To assess variability of the radiation dose to the rectum in manual applicator insertion for uterine cervical cancer treatment, we retrospectively surveyed the dose at the rectal evaluation point (RED) presumed in 175 planning sessions of intracavitary high dose rate brachytherapy performed in 43 patients. A wide variation was found in RED from 52 to 308% of the prescribed dose with a mean of 144%. Posterior flexure of the tandem increased RED 16% in average, and lack of vaginal gauge packing did 19%. The distance of colpostats had a significantly negative relationship with RED. In this study we found significant variation in the rectal exposure by the manual insertion procedure, and it may induce late intractable side effects. (author)

123

High-dose-rate interstitial brachytherapy with computed tomography-based treatment planning for patients with locally advanced uterine cervical carcinoma.  

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The aims of this study were to carry out a dose volume analysis of high-dose-rate interstitial brachytherapy with computed tomography-based treatment planning and to investigate the treatment outcome of patients with locally advanced bulky and/or irregularly shaped uterine cervical carcinoma. Between July 2003 and December 2007, 15 patients were treated with external beam radiation therapy and high-dose-rate interstitial brachytherapy with or without intracavitary brachytherapy. Seven patients were treated with interstitial brachytherapy alone, and 8 were treated with combined use of intracavitary and interstitial brachytherapy. A comparison of the volume and dose parameters with intracavitary and interstitial brachytherapy in patients who received both treatments showed that the median D90 of the high-risk clinical target volume per fraction was 4.4 Gy with intracavitary brachytherapy and 5.6 Gy with interstitial brachytherapy, and the median V100 was 66% with intracavitary brachytherapy and 85% with interstitial brachytherapy. The median D2cc of the bladder with intracavitary and interstitial brachytherapy per fraction was 5.5 Gy and 4.7 Gy, respectively, and the median D2cc of the rectum with intracavitary and interstitial brachytherapy was 5.9 Gy and 4.1 Gy, respectively. The median follow-up time was 37 months, and the overall and progression-free survival rates for all patients at 3 years were 78% and 51%, respectively. The actuarial 2-year and 3-year locoregional control rates were 80% and 71%, respectively. Dose distribution was improved with image-based interstitial brachytherapy, and satisfactory local control was achieved for patients with locally advanced uterine cervical carcinoma in which intracavitary brachytherapy may result in a suboptimal dose distribution. PMID:21785237

Saitoh, Jun-Ichi; Ohno, Tatsuya; Sakurai, Hideyuki; Katoh, Hiroyuki; Wakatsuki, Masaru; Noda, Shin-Ei; Suzuki, Yoshiyuki; Sibuya, Kei; Takahashi, Takeo; Nakano, Takashi

2011-01-01

124

High-dose-rate interstitial brachytherapy with computed tomography-based treatment planning for patients with locally advanced uterine cervical carcinoma  

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The aims of this study were to carry out a dose volume analysis of high-dose-rate interstitial brachytherapy with computed tomography-based treatment planning and to investigate the treatment outcome of patients with locally advanced bulky and/or irregularly shaped uterine cervical carcinoma. Between July 2003 and December 2007, 15 patients were treated with external beam radiation therapy and high-dose-rate interstitial brachytherapy with or without intracavitary brachytherapy. Seven patients were treated with interstitial brachytherapy alone, and 8 were treated with combined use of intracavitary and interstitial brachytherapy. A comparison of the volume and dose parameters with intracavitary and interstitial brachytherapy in patients who received both treatments showed that the median D90 of the high-risk clinical target volume per fraction was 4.4 Gy with intracavitary brachytherapy and 5.6 Gy with interstitial brachytherapy, and the median V100 was 66% with intracavitary brachytherapy and 85% with interstitial brachytherapy. The median D2cc of the bladder with intracavitary and interstitial brachytherapy per fraction was 5.5 Gy and 4.7 Gy, respectively, and the median D2cc of the rectum with intracavitary and interstitial brachytherapy was 5.9 Gy and 4.1 Gy, respectively. The median follow-up time was 37 months, and the overall and progression-free survival rates for all patients at 3 years were 78% and 51%, respectively. The actuarial 2-year and 3-year locoregional control rates were 80% and 71%, respectively. Dose distribution was improved with image-based interstitial brachytherapy, and satisfactory local control was achieved for patients with locally advanced uterine cervical carcinoma in which intracavitary brachytherapy may result in a suboptimal dose distribution. (author)

125

Diagnóstico do parto pré-termo pela medida ultrassonográfica do comprimento do colo uterino / Preterm labor diagnosis by sonographic measurement of the uterine cervical length  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Medir o comprimento do colo uterino, utilizando a ultrassonografia transvaginal, em pacientes com quadro clínico compatível com ameaça de parto pré-termo, e correlacionar a medida do colo uterino, em cada caso, com a interrupção espontânea da gravidez dentro de sete dias. MATERIAIS E MÉTOD [...] OS: Foram realizados exames ultrassonográficos em 72 pacientes com quadro clínico compatível com ameaça de parto pré-termo. RESULTADOS: A sensibilidade do exame foi de 90,5%, a especificidade, de 98%, o valor preditivo positivo, de 95%, e o valor preditivo negativo, de 96%. A análise foi realizada utilizando-se a medida de 15 mm de comprimento do colo uterino como valor preditivo do parto pré-termo. CONCLUSÃO: Parece ser possível prever o parto pré-termo em pacientes com colo uterino menor que 15 mm. Tal observação poderá trazer contribuição para a administração mais oportuna de corticoides, com o intuito de acelerar a maturidade pulmonar fetal. Abstract in english OBJECTIVE: To measure the uterine cervical length by using transvaginal ultrasonography in patients with clinical signs compatible with preterm labor threat, and correlating each individual measurement with spontaneous pregnancy interruption within seven days. MATERIALS AND METHODS: Sonographic exam [...] inations were performed in 72 patients with clinical signs compatible with preterm labor threat. RESULTS: Sensitivity was 90.5%, specificity, 98%, positive predictive value, 95%, and negative predictive value, 96%. A standard uterine cervix length of 15 mm was considered as a predictive value for preterm labor. CONCLUSION: It seems to be possible to foresee preterm delivery in patients whose cervical length is

Carlos Eduardo Ferreira, Novaes; Hilton Augusto, Koch; Carlos Antônio Barbosa, Montenegro; Jorge Fonte de, Rezende Filho.

2009-10-01

126

Diagnóstico do parto pré-termo pela medida ultrassonográfica do comprimento do colo uterino Preterm labor diagnosis by sonographic measurement of the uterine cervical length  

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Full Text Available OBJETIVO: Medir o comprimento do colo uterino, utilizando a ultrassonografia transvaginal, em pacientes com quadro clínico compatível com ameaça de parto pré-termo, e correlacionar a medida do colo uterino, em cada caso, com a interrupção espontânea da gravidez dentro de sete dias. MATERIAIS E MÉTODOS: Foram realizados exames ultrassonográficos em 72 pacientes com quadro clínico compatível com ameaça de parto pré-termo. RESULTADOS: A sensibilidade do exame foi de 90,5%, a especificidade, de 98%, o valor preditivo positivo, de 95%, e o valor preditivo negativo, de 96%. A análise foi realizada utilizando-se a medida de 15 mm de comprimento do colo uterino como valor preditivo do parto pré-termo. CONCLUSÃO: Parece ser possível prever o parto pré-termo em pacientes com colo uterino menor que 15 mm. Tal observação poderá trazer contribuição para a administração mais oportuna de corticoides, com o intuito de acelerar a maturidade pulmonar fetal.OBJECTIVE: To measure the uterine cervical length by using transvaginal ultrasonography in patients with clinical signs compatible with preterm labor threat, and correlating each individual measurement with spontaneous pregnancy interruption within seven days. MATERIALS AND METHODS: Sonographic examinations were performed in 72 patients with clinical signs compatible with preterm labor threat. RESULTS: Sensitivity was 90.5%, specificity, 98%, positive predictive value, 95%, and negative predictive value, 96%. A standard uterine cervix length of 15 mm was considered as a predictive value for preterm labor. CONCLUSION: It seems to be possible to foresee preterm delivery in patients whose cervical length is < 15 mm. Such observation could contribute to a timely corticosteroid administration to accelerate fetal lung maturity.

Carlos Eduardo Ferreira Novaes

2009-10-01

127

Dose to the non-involved uterine corpus with MRI guided brachytherapy in locally advanced cervical cancer  

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Background and purpose: This study evaluates the impact of MRI guided adaptive brachytherapy (BT) on uterine corpus dose. Material and methods: 84 patients with median follow-up of 18 months were analysed. MRI based BT was done according to GEC-ESTRO guidelines. Non-involved uterine corpus at the time of BT was contoured and the uterine corpus dose (D90 and D98) was evaluated for (1) standard loading pattern with source loading to the tip of the tandem and (2) optimised dose plan. Tandem lengths and heights of the 85 Gy isodose were recorded. Results: Dose optimisation resulted in a reduction of active tandem length of 0.4 ± 0.4 cm leading to lowering the D90 to the non-involved uterine corpus from 63.8 ± 9.5 Gy to 56.7 ± 7.5 Gy EQD2 (p < 0.0001). Mean active tandem length was 5.0 ± 1.0 cm, and the height of the 85 Gy isodose was 5.7 ± 1.0 cm in optimised plans. Conclusions: MRI guided dose optimisation lowered the dose to the uterine corpus. However, a total EBRT + BT dose larger than 50 Gy was obtained in 99% of patients. Assuming that 45–50 Gy is sufficient to eradicate microscopic disease, the lowering of uterus corpus dose is not expected to induce additional uterine corpus recurrences in the setting of MRI guided adaptive BT. This hypothesis should be tested in a larger number of patients as e.g. the EMBRACE study

128

Características clínico patológicas del cáncer de cérvix uterino recurrente después de cirugía radical primaria. / Clinical and pathological features of recurrent uterine cervical cancer after primary radical surgery  

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Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Objetivo: Describir las características clínico patológicas del cáncer de cérvix uterino recurrente, sitio y tiempo de recurrencia, y sobrevida después de la recurrencia de acuerdo a las variables de pronóstico en pacientes con cirugía radical primaria. Material y métodos: Estudio descriptivo, obser [...] vacional y retrospectivo, tipo serie de casos, realizado en el Instituto Nacional de Enfermedades Neoplásicas de Lima Perú entre 1990 y 2005. Se incluyeron todas las pacientes con cáncer de cérvix uterino estadios IB1 y IIA a quienes se les realizó cirugía radical primaria y que tuvieron recurrencia. Las curvas de sobrevida fueron construidas con el método de Kaplan-Meier. Resultados: Se realizaron 609 histerectomías radicales tipo III, 53(8,7%) tuvieron recurrencia. La edad promedio al diagnóstico de la recurrencia fue 44,5 años, el tiempo medio desde la cirugía hasta la recurrencia 18,9 meses y el sitio de recurrencia más frecuente fue a distancia (41,5%) seguido por recurrencia central y pélvica. El sitio de recurrencia y los márgenes quirúrgicos tuvieron significancia estadística con respecto al tiempo de recurrencia. La terapia de salvataje más frecuente fue la radioterapia (45%). La sobrevida promedio después de la recurrencia fue 26,9 meses y la tasa de sobrevida a 5 años 9,4%. Conclusiones: El cáncer cervical recurrente es poco frecuente, afecta a mujeres jóvenes y el sitio de recurrencia más frecuente es metástasis a distancia. El tiempo de recurrencia es más corto cuando la recurrencia es central y los márgenes quirúrgicos están afectados. La sobrevida después de la recurrencia en cáncer cervical tratado con cirugía radical es baja. Abstract in english Objective: To describe clinical and pathological features of recurrent uterine cervical cancer, including site and time to recurrence and survival after primary radical surgery. Methods: Descriptive, observational case series study conducted at the Instituto Nacional de Enfermedades Neoplásicas in L [...] ima between 1990 and 2005. Patients with recurrent uterine cervical cancer stages IB1 and IIA who had been treated with primary surgical resection were included. Kaplan-Meir survival curves were constructed. Results: 609 radical hysterectomies type II were performed; 53 (8.7%) had a recurrence. Mean age at diagnosis of recurrence was 44.5 years; mean time from surgery to recurrence was 18.9 months, and the most common site for recurrence was distant recurrence (415%), followed by central recurrence and pelvic recurrence. Site of recurrence and surgical margins had statistical association with time to recurrence. The most frequent salvage therapy was radiotherapy (45%). Mean survival time after recurrence was 26.9 months, and survival rate at 5 years was 9.4%. Conclusions: Recurrent uterine cervical cancer is not frequent, its affects young females causing distant metastasis mainly. Time to recurrence is shorter when recurrence is central and surgical margins are involved. Survival time after recurrence in patients treated surgically is short.

Pedro, Aguilar; Henry, Valdivia.

129

Características clínico patológicas del cáncer de cérvix uterino recurrente después de cirugía radical primaria. / Clinical and pathological features of recurrent uterine cervical cancer after primary radical surgery  

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Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Objetivo: Describir las características clínico patológicas del cáncer de cérvix uterino recurrente, sitio y tiempo de recurrencia, y sobrevida después de la recurrencia de acuerdo a las variables de pronóstico en pacientes con cirugía radical primaria. Material y métodos: Estudio descriptivo, obser [...] vacional y retrospectivo, tipo serie de casos, realizado en el Instituto Nacional de Enfermedades Neoplásicas de Lima Perú entre 1990 y 2005. Se incluyeron todas las pacientes con cáncer de cérvix uterino estadios IB1 y IIA a quienes se les realizó cirugía radical primaria y que tuvieron recurrencia. Las curvas de sobrevida fueron construidas con el método de Kaplan-Meier. Resultados: Se realizaron 609 histerectomías radicales tipo III, 53(8,7%) tuvieron recurrencia. La edad promedio al diagnóstico de la recurrencia fue 44,5 años, el tiempo medio desde la cirugía hasta la recurrencia 18,9 meses y el sitio de recurrencia más frecuente fue a distancia (41,5%) seguido por recurrencia central y pélvica. El sitio de recurrencia y los márgenes quirúrgicos tuvieron significancia estadística con respecto al tiempo de recurrencia. La terapia de salvataje más frecuente fue la radioterapia (45%). La sobrevida promedio después de la recurrencia fue 26,9 meses y la tasa de sobrevida a 5 años 9,4%. Conclusiones: El cáncer cervical recurrente es poco frecuente, afecta a mujeres jóvenes y el sitio de recurrencia más frecuente es metástasis a distancia. El tiempo de recurrencia es más corto cuando la recurrencia es central y los márgenes quirúrgicos están afectados. La sobrevida después de la recurrencia en cáncer cervical tratado con cirugía radical es baja. Abstract in english Objective: To describe clinical and pathological features of recurrent uterine cervical cancer, including site and time to recurrence and survival after primary radical surgery. Methods: Descriptive, observational case series study conducted at the Instituto Nacional de Enfermedades Neoplásicas in L [...] ima between 1990 and 2005. Patients with recurrent uterine cervical cancer stages IB1 and IIA who had been treated with primary surgical resection were included. Kaplan-Meir survival curves were constructed. Results: 609 radical hysterectomies type II were performed; 53 (8.7%) had a recurrence. Mean age at diagnosis of recurrence was 44.5 years; mean time from surgery to recurrence was 18.9 months, and the most common site for recurrence was distant recurrence (415%), followed by central recurrence and pelvic recurrence. Site of recurrence and surgical margins had statistical association with time to recurrence. The most frequent salvage therapy was radiotherapy (45%). Mean survival time after recurrence was 26.9 months, and survival rate at 5 years was 9.4%. Conclusions: Recurrent uterine cervical cancer is not frequent, its affects young females causing distant metastasis mainly. Time to recurrence is shorter when recurrence is central and surgical margins are involved. Survival time after recurrence in patients treated surgically is short.

Pedro, Aguilar; Henry, Valdivia.

2012-03-01

130

An assessment of interfractional uterine and cervical motion: Implications for radiotherapy target volume definition in gynaecological cancer  

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illing has more impact on uterine body position, highlighting the need for specific instructions on bladder and rectal filling for treatment. We propose an asymmetrical margin with CTV-PTV expansion of the uterus, cervix and upper vagina of 15 mm AP, 15 mm SI and 7 mm laterally and expansion of the nodal regions and parametria by 7 mm in all directions

131

Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino Human papillomavirus genotyping of cervical uterine preneoplastic lesions in a high risk area  

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Full Text Available The relationship between human papillomavirus (HPV and uterine cervical cancer (UCC is widely known and accepted. Aim: To determine the frequency of genotypes of HPV in cervical preneoplastic lesions in a high risk area of UCC. Material and Methods: Using a combination of PCR and Reverse Line Blot technique, 235 formalin fixed paraffin embedded samples, with diagnosis of low-grade squamous intraepithelial lesion (LSIL or high-grade squamous intraepithelial lesion (HSIL were genotyped. Results: HPV was detected in 61.2% of LSIL and 78.1% of HSIL. The main genotypes found were HPV 16, 18, 31, 45, 56 y 58. HPV 16 was the most common in both LSIL (18.1% and HSIL (36.9%. HPV 16 or 18 were present in 25.1% and 47.1% of the LSIL and HSIL respectively. In both LSIL and HSIL, the predominant viral genotypes were those types classified as with a high oncogenic risk. Conclusions: HPV genotypes 16, 18, 31, 45, 56 y 58 were the most common in our series. HPV 16 and 18, viral types with high oncogenic risk and included in commercial vaccines, were found in 25.1% and 47.1% of LSIL and HSIL, respectively.

JAIME LÓPEZ M

2010-11-01

132

Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino / Human papillomavirus genotyping of cervical uterine preneoplastic lesions in a high risk area  

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Full Text Available SciELO Chile | Language: Spanish Abstract in spanish [...] Abstract in english The relationship between human papillomavirus (HPV) and uterine cervical cancer (UCC) is widely known and accepted. Aim: To determine the frequency of genotypes of HPV in cervical preneoplastic lesions in a high risk area of UCC. Material and Methods: Using a combination of PCR and Reverse Line Blot [...] technique, 235 formalin fixed paraffin embedded samples, with diagnosis of low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL) were genotyped. Results: HPV was detected in 61.2% of LSIL and 78.1% of HSIL. The main genotypes found were HPV 16, 18, 31, 45, 56 y 58. HPV 16 was the most common in both LSIL (18.1%) and HSIL (36.9%). HPV 16 or 18 were present in 25.1% and 47.1% of the LSIL and HSIL respectively. In both LSIL and HSIL, the predominant viral genotypes were those types classified as with a high oncogenic risk. Conclusions: HPV genotypes 16, 18, 31, 45, 56 y 58 were the most common in our series. HPV 16 and 18, viral types with high oncogenic risk and included in commercial vaccines, were found in 25.1% and 47.1% of LSIL and HSIL, respectively.

JAIME, LÓPEZ M; CARMEN GLORIA, ILI G; PRISCILLA, BREBI M; PATRICIA, GARCÍA M; ITALO, CAPURRO V; PABLO, GUZMÁN G; EUGENIO, SUÁREZ P; JOSÉ MANUEL, OJEDA F; JUAN CARLOS, ROA S.

1343-13-01

133

Screening for uterine tumours.  

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The most prevalent uterine tumours are leiomyomas, which are benign and have a prevalence of about 50% at menopause. The incidence of endometrial cancer and uterine sarcomas is about 25 per 100,000 and 0.7 per 100,000, respectively. Reported risk factors for endometrial cancer are advanced age, unopposed oestrogen stimulation, late menopause, obesity, diabetes mellitus, nulliparity, feminising ovarian tumours, polycystic ovarian syndrome, tamoxifen and belonging to a hereditary non-polyposis colorectal cancer family. Unopposed oestrogen stimulation and tamoxifen have also been confirmed to induce uterine sarcomas. Cervical cytology, endometrial sampling and ultrasound have been proposed in the early diagnosis of endometrial cancer. No pathognomonic ultrasound, magnetic resonance imaging or computed tomography features are able to differentiate between a leiomyoma and a uterine sarcoma, and reliable serum markers for sarcomas are lacking. To date, mass screening for uterine malignancies is not feasible or effective. PMID:22078749

Van den Bosch, Thierry; Coosemans, An; Morina, Memli; Timmerman, Dirk; Amant, Frederic

2012-04-01

134

Conocimientos sobre prevención del cáncer cérvico-uterino en los adolescentes / Knowledge on the prevention of the cervical-uterine cancer in the adolescents  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish En Cuba, al igual que en el resto de los países occidentales, el cáncer cérvico-uterino se encuentra en segundo lugar de morbilidad oncológica en mujeres de 20 a 30 años; y a ctualmente está considerado como una infección de transmisión sexual. Hay estudios que revelan información deficiente por par [...] te de los adolescentes en cuanto a las infecciones de transmisión sexual y sus consecuencias. Es por ello, que en el período comprendido entre febrero y noviembre de 2009 se realizó una investigación descriptiva con el objetivo de identificar los conocimientos sobre prevención del cáncer cérvico-uterino en los adolescentes de la ESBU Manuel Sanguily, del municipio Matanzas. El universo estuvo integrado por los alumnos de noveno grado, y para la selección de la muestra se utilizó un muestreo probabilístico por conglomerados monoetápico. Se aplicó un cuestionario, cuyos resultados relevantes indicaron que los varones iniciaron sus primeras relaciones sexuales a los 13 años y las hembras a las edades de 13 y 14 años, representado un 57,1 % y 50 %, respectivamente. Solo el 12,7 % de los adolescentes identificó al virus del papiloma humano como factor de riesgo en la génesis del cáncer cérvico-uterino. El bajo nivel de conocimientos para la prevención de este tipo de cáncer predominó en el 92,7 % de la muestra. Se concluye que en el grupo de adolescentes estudiados, lo más frecuente fue el inicio temprano de las relaciones sexuales, tanto para varones como para hembras, aunque estas últimas representaron solo el 10 %. Se identificó desconocimiento sobre el virus del papiloma humano como agente causal de esta morbilidad, y pobre conocimiento sobre cómo prevenirlo. Abstract in english In Cuba, as in the rest of the Western countries, the cervical-uterine cancer is in the second place of oncologic morbidity in 20-to-30 years-old women; currently it is considered a sexually transmitted infection. There are some studies revealing deficient information on the part of the teenagers as [...] for the sexually transmitted diseases and theirs consequences. That is why, in the period from February to November 2009 we carried out a descriptive investigation with the objective of identifying the knowledge on the prevention of the cervical-uterine cancer the students of the Secondary School Manuel Sanguily, Municipality of Matanzas, have. The universe was formed by the nine grade students, and to select the sample we used a probabilistic sampling by mono-stage conglomerates. A questionnaire was applied and the results indicated that the males began their first sexual relationships to the 13 years and the females to the ages of 13 and 14 years, representing 57,1 % and 50 %, respectively. Only 12,7 % of the teenagers identified the human papilloma virus as a risk factor in the genesis of the cervical-uterine cancer. The low level of knowledge for the prevention of this kind of cancer prevailed in 92,7 % of the sample. We concluded that in the group of teenagers we studied, the most frequent fact was that they began early having sexual relationships, both boys and girls, although the last ones represented only 10 %. We identified ignorance on the human papilloma virus and poor knowledge about how to prevent it as the casual agent of this morbidity.

Regla Mercedes, García Rosique; Adelaida, Torres Triana; Marlén, Rendón Quintero.

135

La promoción de salud dirigida a reducir los factores de riesgo de cáncer cérvico uterino / Health promotion aimed to reducing uterine cervical cancer risk factors  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish La primera Conferencia Internacional sobre la Promoción de la Salud celebrada en Ottawa, el 21 de noviembre de 1986, definió la promoción de la salud como “el proceso de permitir a la gente aumentar su control sobre su salud y por lo tanto mejorarla”. Se reconoce claramente que la promoción de la sa [...] lud va más allá de los estilos de vida, en la cual la educación para la salud constituye, junto a la comunicación y a la participación social, herramientas necesarias para su instrumentación en el primer nivel de atención. En la práctica cotidiana se desconoce de forma reiterada el valor que tiene el reconocimiento adecuado de las dimensiones de la promoción de salud, desde una perspectiva holística, dirigidas a reducir los factores de riesgo de cáncer cérvico uterino. El propósito del estudio fue realizar una contribución teórica a la promoción de salud para contribuir al fortalecimiento del Programa Nacional de Diagnóstico Precoz del Cáncer Cérvico Uterino. Al considerar el valor de esta disciplina desde sus dimensiones, el profesional de la salud dispone de una base teórica que guíe las acciones dirigidas a la reducción de factores de riesgos de este tipo de cáncer en la población femenina. Abstract in english The first International Conference on Health Promotion celebrated in Ottawa on November 21st, 1986, defined health promotion as “the process allowing people to increase the control on their health and therefore to improve it”. It is clearly understood that health promotion goes beyond life styles, a [...] nd also includes education for health, communication and social participation, necessary tools for its instrumentation in the first health care level. In every day practice it is continually not recognized the value of the adequate acknowledgement of health promotion dimensions, from a holistic perspective, aimed to reducing the uterine cervical cancer risk factors. The purpose of the research was theoretically contributing to the strengthening of the National Program of Uterine Cervical Cancer Precocious Diagnosis. When considering the value of this discipline in all its dimensions, the health care professional has a theoretical base to guide the actions aimed to reducing the risk factors of this kind of cancer among the female population.

Misleny, Martínez Pérez; Juan Carlos, de la Concepción Cárdenas; Ariel, Pérez González.

136

La promoción de salud dirigida a reducir los factores de riesgo de cáncer cérvico uterino / Health promotion aimed to reducing uterine cervical cancer risk factors  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish La primera Conferencia Internacional sobre la Promoción de la Salud celebrada en Ottawa, el 21 de noviembre de 1986, definió la promoción de la salud como “el proceso de permitir a la gente aumentar su control sobre su salud y por lo tanto mejorarla”. Se reconoce claramente que la promoción de la sa [...] lud va más allá de los estilos de vida, en la cual la educación para la salud constituye, junto a la comunicación y a la participación social, herramientas necesarias para su instrumentación en el primer nivel de atención. En la práctica cotidiana se desconoce de forma reiterada el valor que tiene el reconocimiento adecuado de las dimensiones de la promoción de salud, desde una perspectiva holística, dirigidas a reducir los factores de riesgo de cáncer cérvico uterino. El propósito del estudio fue realizar una contribución teórica a la promoción de salud para contribuir al fortalecimiento del Programa Nacional de Diagnóstico Precoz del Cáncer Cérvico Uterino. Al considerar el valor de esta disciplina desde sus dimensiones, el profesional de la salud dispone de una base teórica que guíe las acciones dirigidas a la reducción de factores de riesgos de este tipo de cáncer en la población femenina. Abstract in english The first International Conference on Health Promotion celebrated in Ottawa on November 21st, 1986, defined health promotion as “the process allowing people to increase the control on their health and therefore to improve it”. It is clearly understood that health promotion goes beyond life styles, a [...] nd also includes education for health, communication and social participation, necessary tools for its instrumentation in the first health care level. In every day practice it is continually not recognized the value of the adequate acknowledgement of health promotion dimensions, from a holistic perspective, aimed to reducing the uterine cervical cancer risk factors. The purpose of the research was theoretically contributing to the strengthening of the National Program of Uterine Cervical Cancer Precocious Diagnosis. When considering the value of this discipline in all its dimensions, the health care professional has a theoretical base to guide the actions aimed to reducing the risk factors of this kind of cancer among the female population.

Misleny, Martínez Pérez; Juan Carlos, de la Concepción Cárdenas; Ariel, Pérez González.

2014-06-01

137

Studies on serum protein fractions of patients with uterine cervical cancer undergoing radiotherapy. Relationship between changes in serum protein fractions and prognosis  

International Nuclear Information System (INIS)

The purpose of this study was to evaluate the correlation between changes in serum protein fractions and patient prognosis. The subjects were 84 patients with uterine cervical cancer treated with combined external pelvic irradiation and intracavitary irradiation using a remote afterloading system (RALS). Twenty one normal women served as controls. Serum levels of 23 protein components were determined before and after radiotherapy. All patients were followed up for 4 to 8 years after radiotherapy. Pretreatment serum levels of prealbumin (Prealb), ?2HS glycoprotein (?2HS), ?2-plasmin inhibitor (?2PI), transferrin (Tf), plasminogen (Pmg), albumin (Alb), IgM, and hemopexin (Hx) were significantly lower in the group of cervical cancer patients than the control group; and serum levels of ?1-antichymotrypsin (?1X), haptoglobin (Hp), C9, fibrinogen (Fib), ceruloplasmin (Cp), ?1-acid glycoprotein (?1AG), ?1-antitrypsin (?1AT), and C4 were elevated. At the completion of radiotherapy, HP, C4, and Fib levels were significantly lower than those before radiotherapy; Prealb, ?2HS, and ?2PI were elevated. In patients who survived 4 years and 8 years, pretreatment levels of Cp, ?1AG, Hp, and C9 were significantly reduced and Tf was elevated, as compared with those who died within 4 years. In those who survived more than 4 years, posttreatment levels of ?1AT, Hp, ?1X, Cp, and C9 were significantly reduced, although the serum level of C4 was elevated. Survival positively correlated with pretreatment levels of Tf, Pmg, and ?1AT, but negatively correlated with AT III, Cp, C1Inh, IgA, ?1AG, and C9. For posttreatment levels, it positively correlated with Pmg, C4, Prealb, Alb, ?2M, and Hp, but negatively correlated with Tf, ?2PI, AT III, ?1AT, C1Inh, C9, and IgA. (N.K.)

138

A Dose-Volume Analysis of Magnetic Resonance Imaging-Aided High-Dose-Rate Image-Based Interstitial Brachytherapy for Uterine Cervical Cancer  

International Nuclear Information System (INIS)

Purpose: To investigate the feasibility of our novel image-based high-dose-rate interstitial brachytherapy (HDR-ISBT) for uterine cervical cancer, we evaluated the dose-volume histogram (DVH) according to the recommendations of the Gynecological GEC-ESTRO Working Group for image-based intracavitary brachytherapy (ICBT). Methods and Materials: Between June 2005 and June 2007, 18 previously untreated cervical cancer patients were enrolled. We implanted magnetic resonance imaging (MRI)-available plastic applicators by our unique ambulatory technique. Total treatment doses were 30-36 Gy (6 Gy per fraction) combined with external beam radiotherapy (EBRT). Treatment plans were created based on planning computed tomography with MRI as a reference. DVHs of the high-risk clinical target volume (HR CTV), intermediate-risk CTV (IR CTV), and the bladder and rectum were calculated. Dose values were biologically normalized to equivalent doses in 2-Gy fractions (EQD2). Results: The median D90 (HR CTV) and D90 (IR CTV) per fraction were 6.8 Gy (range, 5.5-7.5) and 5.4 Gy (range, 4.2-6.3), respectively. The median V100 (HR CTV) and V100 (IR CTV) were 98.4% (range, 83-100) and 81.8% (range, 64-93.8), respectively. When the dose of EBRT was added, the median D90 and D100 of HR CTV were 80.6 Gy (range, 65.5-96.6) and 62.4 Gy (range, 49-83.2). The D2cc of the bladder was 62 Gy (range, 51.4-89) and of the rectum was 65.9 Gy (range, 48.9-76). Conclusions: Although the ange, 48.9-76). Conclusions: Although the targets were advanced and difficult to treat effectively by ICBT, MRI-aided image-based ISBT showed favorable results for CTV and organs at risk compared with previously reported image-based ICBT results.

139

The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in the uterine cervix and cervical squamous neoplasia.  

Science.gov (United States)

This is a retrospective study, in which PC10, a monoclonal antibody against proliferating cell nuclear antigen (PCNA) was used in the assessment of 20 cases of FIGO stage IB cervical carcinoma, 30 cases of CIN, 10 cases of koilocytosis and 20 cases in which the transformation zone was histologically normal. The results showed that in the normal transformation zone the proliferative compartment was confined to the first 1-2 suprabasal cell layers. In CIN the pattern of staining corresponded to the grade of the lesion. In viral wart lesions occasional koilocytes demonstrated strong nuclear staining. In all cases of stage IB cervical carcinoma the PC10 index was high, irrespective of tumor grade response to treatment. PMID:11578336

Al-Nafussi, A.I.; Klys, H.S.; Rebello, G.; Kelly, C.; Kerr, G.; Cowie, V.

1993-05-01

140

Protein p 16INK4A expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of uterine cervix  

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Full Text Available The association of human papilloma virus (HPV infection and cervical intraepithelial neoplasia (CIN is well recognized. Interaction of HPV oncogenic proteins with cellular regulatory proteins leads to up regulation of p16 INK4A , a CDK inhibitor, which is a biomarker for HPV infection. We investigated p16 expression in CIN and invasive squamous cell carcinoma (SCC which has not been reported in the Indian population previously. Materials and Methods: Retrospective analysis of 100 cases with 20 cases each of histologically normal cervical epithelium, CIN1, 2, 3 and invasive SCC for p16 expression was performed by immunohistochemistry using commercially available mouse monoclonal antibody to p16 (clone 6H12. Statistical Analysis: For differences in expression among groups, statistical analysis was carried out using ANOVA and post hoc test of Scheffe. Results: p16 immunoreactivity was found to be both nuclear and/or cytoplasmic. The normal cervical epithelium was predominantly negative for p16 (18/20. There was a progressive increase of p16 expression with the grade of CIN. In CIN 1, two cases (20% showed nuclear and nucleocytoplasmic positivity respectively. In contrast, diffuse strong nuclear or nucleocytoplasmic expression was observed in 45 and 55% cases of CIN 2 and CIN 3 respectively. All except one squamous cell carcinoma stained strongly positive for p16. The difference in expression between CIN 2/3 and SCC versus normal cervix was found highly significant (p is equal to 0.008 and p less than 0.001. Conclusions: p16 expression correlates excellently with the grade of CIN and is a sensitive marker of cervical intraepithelial neoplasia.

Gupta Ruchi

2010-01-01

 
 
 
 
141

Pelvic lymph node invasion in cervical cancer; L`envahissement ganglionnaire pelvien dans les cancers du col uterin  

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Pelvic lymph node invasion is an important prognostic factor for cervical cancer. It is generally accepted that iliac lymph nodes must be treated systematically, but the extent of lymph node dissections is open to discussion. One hundred and eighty two cases of cervical cancer with lymph node invasion were treated at the Institut Curie between 1960 and 1988, by colpophysterectomy with lymph node dissection (168 cases) combined with preoperative brachytherapy and, in some cases, pre- and/or postoperative radiotherapy; in 14 cases, only an exploratory operation was performed. External iliac lymph node invasion was found in 95% of cases, situated in the middle and internal chains. Common iliac lymph node invasion was found in 24% of cases, but was only exceptionally isolated (3%). It is therefore possible, by means of well defined, localized external iliac dissection, with frozen section histological examination, to determine the exact lymph node status. Lumboaortic lymph node invasion was found in 8.2% of cases. The overall survival rate was 49% at 5 years and 40.5% at 10 years. Factors which influence survival are: the cervical volume (p = 0.015), the unilateral or bilateral nature of invasion (p = 0.0015), the number of lymph nodes invaded (two or more than two) (p = 0.0001), capsular rupture (p = 0.0008), lymph node adhesions other than venous (p = 0.0002), common iliac invasion (p 0.0001). On Cox`s model, the principal factors were the number of lymph nodes invaded, adhesion other than venous, common iliac invasion; on the other hand, venous adhesion does not modify the prognosis. The five-year survival rates following external iliac dissections and complete pelvic dissections were not significantly different. Finally, postoperative radiotherapy ensured a higher five-year survival rate than preoperative radiotherapy, but the cervical volume was greater and primary invasion was more frequent in these cases. (Abstract Truncated)

Renolleau, C.; Laroussinie, M.P.; Mosseri, V.; Fenton, J.; De la Rochefordiere, A.; Clough, K.B.; Hamelin, J.P.; Durand, J.C. [Institut Curie, 75 - Paris (France)

1995-12-31

142

Prediction of lymph node status in uterine cervical cancer with 18FDG-PET/CT-value of primary tumor uptake  

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Purpose. To evaluate the value of 18F-fluoro-2-deoxyglucose (F.D.G.) PET-CT and maximal standardized uptake value (SUVmax) of the primary tumor for lymph node staging in cervical cancer. Materials and methods. This retrospective study involved a series of 18 consecutive patients who had benefited from PET-CT and MRI at initial staging for a stage IB or higher cervical carcinoma. The SUVmax of each primary tumor was measured retrospectively. All patients had been previously treated by radio chemotherapy. Lymph node status was obtained in 12 of 18 cases. Results. The sensitivity and specificity for determining lymph node status was 80 and 86%, respectively, for PET-CT, and 80 and 71% for MRI. In 16.6% of cases, PET-CT revealed unknown sus-diaphragmatic lesions. SUVmax of the primary tumor was significantly higher in the N+ than in the N- group (15.6 ±1.6 vs 8.5±3.9, p max of a primary cervical cancer seems to be a good predictor of lymph node status. This could lead to an intensification of treatment for patients whose SUVmax is higher than 10.8. A prospective study would allow to assess a potential benefit of treatment intensification for patients with SUVmax higher than 10.8. (authors)

143

Diferencias sociales de la detección oportuna de cáncer cérvico uterino en las mujeres trabajadoras de una universidad de la ciudad de México / Social Differences in Proper Detection of Cervical Uterine Cancer among Employees at a University in Mexico City  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Fundamento: En México el cáncer cérvicouterino (CACU) es una de las principales causas de muerte en mujeres; sin embargo, se ha encontrado una baja participación en los programas de su detección oportuna (DOCACU). El objetivo de este estudio fue describir los determinantes sociales del conocimiento [...] sobre el cáncer cérvicouterino y la realización de la detección oportuna estableciendo las diferencias sociales que al respecto muestra una población de mujeres trabajadoras de una universidad pública de México. Métodos: Se realizó un estudio transversal analítico. Entre marzo y abril de 2003 se aplicó una encuesta a una muestra representativa de las trabajadoras que laboraban en una universidad pública (n=228), 110 eran académicas (AC) y 118 administrativas (AD). Se eligió esta población por su elevada diferenciación socioeconómica en función del puesto laboral (AC vs. AD), esto permitió evaluar la influencia de la desigualdad social sobre las conductas en salud. La encuesta exploró tres aspectos: condiciones de vida, conocimiento del CACU y DOCACU. Resultados: Las mujeres académicas mostraron mayores niveles de ingreso, escolaridad, conocimiento del CACU y DOCACU que las administrativas. El ingreso y la escolaridad se relacionaron positivamente con el conocimiento sobre el cáncer cervicouterino, la realización de detección oportuna se relacionó con este último. Conclusiones: La desigualdad socioeconómica entre las mujeres estudiadas se reflejó en diferencias en el grado de conocimiento y en la práctica de la detección oportuna. Estas diferencias se asocian, sobre todo, a las diferencias en el grado de escolaridad. Abstract in english Background: In Mexico, cervical uterine cancer (CUC) is one of the leading causes of death among women, however a low degree of participation in the early detection programs has been found. This study is aimed at describing the social determinants of knowledge related to cervical uterine cancer and [...] proper testing being conducted by establishing the social differences with regard thereto among a population of female employees at a public university in Mexico. Methods: An analytical cross-sectional study was made. During the March-April 2003 period, a survey was conducted of a representative sample of the female employees who were working at a public university (n=228), 110 of whom were professors (PF) and 118 administrative staff (AS). This population was chosen due to the major socioeconomic differentiation thereof in terms of their job positions (PF versus AS), thus affording the possibility of evaluating the bearing social inequality has on health-related behavior. The survey explored three aspects: living conditions, knowledge of CUC and of proper cervical uterine cancer detection testing. Results: The female professors showed higher levels of income, schooling and knowledge of CUC and of cervical uterine cancer detection testing than the administrative staff. Income and schooling were positively related to the knowledge regarding cervical uterine cancer, cervical uterine cancer detection testing being related to the latter. Conclusions: Socioeconomic inequality among the women studied was reflected in differences in the degree of knowledge and in cervical uterine cancer detection testing being undergone. These differences are associated, above all, to the differences in the level of schooling.

Ulises, Trejo Amador; José Arturo, Granados Cosme; Luis, Ortiz Hernández; Guadalupe, Delgado Sánchez.

144

Diferencias sociales de la detección oportuna de cáncer cérvico uterino en las mujeres trabajadoras de una universidad de la ciudad de México / Social differences in proper detection of cervical uterine cancer among employees at a university in Mexico City  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: Spanish Abstract in spanish Fundamento: En México el cáncer cérvicouterino (CACU) es una de las principales causas de muerte en mujeres; sin embargo, se ha encontrado una baja participación en los programas de su detección oportuna (DOCACU). El objetivo de este estudio fue describir los determinantes sociales del conocimiento [...] sobre el cáncer cérvicouterino y la realización de la detección oportuna estableciendo las diferencias sociales que al respecto muestra una población de mujeres trabajadoras de una universidad pública de México. Métodos: Se realizó un estudio transversal analítico. Entre marzo y abril de 2003 se aplicó una encuesta a una muestra representativa de las trabajadoras que laboraban en una universidad pública (n=228), 110 eran académicas (AC) y 118 administrativas (AD). Se eligió esta población por su elevada diferenciación socioeconómica en función del puesto laboral (AC vs. AD), esto permitió evaluar la influencia de la desigualdad social sobre las conductas en salud. La encuesta exploró tres aspectos: condiciones de vida, conocimiento del CACU y DOCACU. Resultados: Las mujeres académicas mostraron mayores niveles de ingreso, escolaridad, conocimiento del CACU y DOCACU que las administrativas. El ingreso y la escolaridad se relacionaron positivamente con el conocimiento sobre el cáncer cervicouterino, la realización de detección oportuna se relacionó con este último. Conclusiones: La desigualdad socioeconómica entre las mujeres estudiadas se reflejó en diferencias en el grado de conocimiento y en la práctica de la detección oportuna. Estas diferencias se asocian, sobre todo, a las diferencias en el grado de escolaridad. Abstract in english Background: In Mexico, cervical uterine cancer (CUC) is one of the leading causes of death among women, however a low degree of participation in the early detection programs has been found. This study is aimed at describing the social determinants of knowledge related to cervical uterine cancer and [...] proper testing being conducted by establishing the social differences with regard thereto among a population of female employees at a public university in Mexico. Methods: An analytical cross-sectional study was made. During the March-April 2003 period, a survey was conducted of a representative sample of the female employees who were working at a public university (n=228), 110 of whom were professors (PF) and 118 administrative staff (AS). This population was chosen due to the major socioeconomic differentiation thereof in terms of their job positions (PF versus AS), thus affording the possibility of evaluating the bearing social inequality has on health-related behavior. The survey explored three aspects: living conditions, knowledge of CUC and of proper cervical uterine cancer detection testing. Results: The female professors showed higher levels of income, schooling and knowledge of CUC and of cervical uterine cancer detection testing than the administrative staff. Income and schooling were positively related to the knowledge regarding cervical uterine cancer, cervical uterine cancer detection testing being related to the latter. Conclusions: Socioeconomic inequality among the women studied was reflected in differences in the degree of knowledge and in cervical uterine cancer detection testing being undergone. These differences are associated, above all, to the differences in the level of schooling.

Ulises, Trejo Amador; José Arturo, Granados Cosme; Luis, Ortiz Hernández; Guadalupe, Delgado Sánchez.

145

Diferencias sociales de la detección oportuna de cáncer cérvico uterino en las mujeres trabajadoras de una universidad de la ciudad de México / Social Differences in Proper Detection of Cervical Uterine Cancer among Employees at a University in Mexico City  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Fundamento: En México el cáncer cérvicouterino (CACU) es una de las principales causas de muerte en mujeres; sin embargo, se ha encontrado una baja participación en los programas de su detección oportuna (DOCACU). El objetivo de este estudio fue describir los determinantes sociales del conocimiento [...] sobre el cáncer cérvicouterino y la realización de la detección oportuna estableciendo las diferencias sociales que al respecto muestra una población de mujeres trabajadoras de una universidad pública de México. Métodos: Se realizó un estudio transversal analítico. Entre marzo y abril de 2003 se aplicó una encuesta a una muestra representativa de las trabajadoras que laboraban en una universidad pública (n=228), 110 eran académicas (AC) y 118 administrativas (AD). Se eligió esta población por su elevada diferenciación socioeconómica en función del puesto laboral (AC vs. AD), esto permitió evaluar la influencia de la desigualdad social sobre las conductas en salud. La encuesta exploró tres aspectos: condiciones de vida, conocimiento del CACU y DOCACU. Resultados: Las mujeres académicas mostraron mayores niveles de ingreso, escolaridad, conocimiento del CACU y DOCACU que las administrativas. El ingreso y la escolaridad se relacionaron positivamente con el conocimiento sobre el cáncer cervicouterino, la realización de detección oportuna se relacionó con este último. Conclusiones: La desigualdad socioeconómica entre las mujeres estudiadas se reflejó en diferencias en el grado de conocimiento y en la práctica de la detección oportuna. Estas diferencias se asocian, sobre todo, a las diferencias en el grado de escolaridad. Abstract in english Background: In Mexico, cervical uterine cancer (CUC) is one of the leading causes of death among women, however a low degree of participation in the early detection programs has been found. This study is aimed at describing the social determinants of knowledge related to cervical uterine cancer and [...] proper testing being conducted by establishing the social differences with regard thereto among a population of female employees at a public university in Mexico. Methods: An analytical cross-sectional study was made. During the March-April 2003 period, a survey was conducted of a representative sample of the female employees who were working at a public university (n=228), 110 of whom were professors (PF) and 118 administrative staff (AS). This population was chosen due to the major socioeconomic differentiation thereof in terms of their job positions (PF versus AS), thus affording the possibility of evaluating the bearing social inequality has on health-related behavior. The survey explored three aspects: living conditions, knowledge of CUC and of proper cervical uterine cancer detection testing. Results: The female professors showed higher levels of income, schooling and knowledge of CUC and of cervical uterine cancer detection testing than the administrative staff. Income and schooling were positively related to the knowledge regarding cervical uterine cancer, cervical uterine cancer detection testing being related to the latter. Conclusions: Socioeconomic inequality among the women studied was reflected in differences in the degree of knowledge and in cervical uterine cancer detection testing being undergone. These differences are associated, above all, to the differences in the level of schooling.

Ulises, Trejo Amador; José Arturo, Granados Cosme; Luis, Ortiz Hernández; Guadalupe, Delgado Sánchez.

2005-06-01

146

Diferencias sociales de la detección oportuna de cáncer cérvico uterino en las mujeres trabajadoras de una universidad de la ciudad de México / Social differences in proper detection of cervical uterine cancer among employees at a university in Mexico City  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: Spanish Abstract in spanish Fundamento: En México el cáncer cérvicouterino (CACU) es una de las principales causas de muerte en mujeres; sin embargo, se ha encontrado una baja participación en los programas de su detección oportuna (DOCACU). El objetivo de este estudio fue describir los determinantes sociales del conocimiento [...] sobre el cáncer cérvicouterino y la realización de la detección oportuna estableciendo las diferencias sociales que al respecto muestra una población de mujeres trabajadoras de una universidad pública de México. Métodos: Se realizó un estudio transversal analítico. Entre marzo y abril de 2003 se aplicó una encuesta a una muestra representativa de las trabajadoras que laboraban en una universidad pública (n=228), 110 eran académicas (AC) y 118 administrativas (AD). Se eligió esta población por su elevada diferenciación socioeconómica en función del puesto laboral (AC vs. AD), esto permitió evaluar la influencia de la desigualdad social sobre las conductas en salud. La encuesta exploró tres aspectos: condiciones de vida, conocimiento del CACU y DOCACU. Resultados: Las mujeres académicas mostraron mayores niveles de ingreso, escolaridad, conocimiento del CACU y DOCACU que las administrativas. El ingreso y la escolaridad se relacionaron positivamente con el conocimiento sobre el cáncer cervicouterino, la realización de detección oportuna se relacionó con este último. Conclusiones: La desigualdad socioeconómica entre las mujeres estudiadas se reflejó en diferencias en el grado de conocimiento y en la práctica de la detección oportuna. Estas diferencias se asocian, sobre todo, a las diferencias en el grado de escolaridad. Abstract in english Background: In Mexico, cervical uterine cancer (CUC) is one of the leading causes of death among women, however a low degree of participation in the early detection programs has been found. This study is aimed at describing the social determinants of knowledge related to cervical uterine cancer and [...] proper testing being conducted by establishing the social differences with regard thereto among a population of female employees at a public university in Mexico. Methods: An analytical cross-sectional study was made. During the March-April 2003 period, a survey was conducted of a representative sample of the female employees who were working at a public university (n=228), 110 of whom were professors (PF) and 118 administrative staff (AS). This population was chosen due to the major socioeconomic differentiation thereof in terms of their job positions (PF versus AS), thus affording the possibility of evaluating the bearing social inequality has on health-related behavior. The survey explored three aspects: living conditions, knowledge of CUC and of proper cervical uterine cancer detection testing. Results: The female professors showed higher levels of income, schooling and knowledge of CUC and of cervical uterine cancer detection testing than the administrative staff. Income and schooling were positively related to the knowledge regarding cervical uterine cancer, cervical uterine cancer detection testing being related to the latter. Conclusions: Socioeconomic inequality among the women studied was reflected in differences in the degree of knowledge and in cervical uterine cancer detection testing being undergone. These differences are associated, above all, to the differences in the level of schooling.

Ulises, Trejo Amador; José Arturo, Granados Cosme; Luis, Ortiz Hernández; Guadalupe, Delgado Sánchez.

2005-06-01

147

Cerebral metastasis of cervical uterine cancer: report of three cases / Metástases cerebrais de câncer de colo de útero: relato de três casos  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese Tumores do cólo uterino se disseminam por contigüidade ou via hematogênica (pulmão, fígado e ossos). Metástases para sistema nervoso central são incomuns. Apenas cerca de 80 casos são citados na literatura. Manifestações clínicas são devidas à hipertensão intracraniana e a déficits focais. A sobrevi [...] da varia de 3 a 6 meses. Três casos são relatados sendo um infratentorial e dois supratentoriais. No primeiro, o diagnóstico da metástase antecedeu o da lesão uterina. No segundo, houve 5 anos sem recidiva após a cirurgia, fato este inédito. O tratamento foi cirurgia, radioterapia e/ou quimioterapia. A discussão enfatiza manejo multidisciplinar destas raras lesões. Abstract in english Cervical uterine cancer (CUC) spreads locally (pelvis and paraortic lymphnodes) or distantly (lungs, liver and bones). Metastasis to central nervous system (CNS) are rare. There are about 80 cases reported in the literature. Outcome is poor and survival varies from 3 to 6 months. Three cases of CNS [...] metastasis from CUC are reported, one infratentorial and two supratentorials in location. In one patient, the initial manifestation was due to the cerebral lesion, a feature reported for the first time. All cases were treated by surgery, radiotherapy and/or chemotherapy. Clinical findings and treatment options of these rare lesions are reviewed.

Joacir Graciolli, Cordeiro; Daniel Monte-Serrat, Prevedello; Léo Fernando da Silva, Ditzel; Carlos Umberto, Pereira; João Cândido, Araújo.

2006-06-01

148

Results of radiotherapy for stage III uterine cervical carcinomas and preliminary study of combined radiotherapy and transarterial infusion chemotherapy  

International Nuclear Information System (INIS)

This is a retrospective analysis of 55 patients with stage III carcinoma of the uterine cervix treated with radiation from November 1984 through December 1991. Eleven of the patients were treated with radiation and transarterial infusion chemotherapy (TAI), using cis-platinum and pepleomycin. The 3- and 5-year cumulative survival rates for all patients were 61% and 58%, respectively, and the 3-year cumulative survival rate for the group with combined radiation and TAI was 47%. According to initial failure site, the locoregional recurrence rate was 36.8%, and that for para-aortic lymph node metastasis and distant metastasis was 31.6%. The failure pattern was similar between the irradiation only group and the group with combined radiation and TAI. The incidence of intestinal complications of grades 1 and 2 was 20%. Irradiation combined with TAI did not increase the incidence of complications. (author)

149

Invasive cervical carcinoma: methods of investigation, diagnostic strategy; Carcinomes invasifs du col uterin: methodes d`exploration strategie diagnostique  

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The authors review various techniques, including endo-sonography, computed tomography, magnetic resonance imaging and lymphography for the pre therapeutic evaluation of cancer of the uterine cervix, as well as for post therapeutic follow up. The pre-therapeutic examination should evaluate size of the primary tumor and tumor extension to vagina, parametria, bladder, rectum and pelvic sidewall. Pelvic lymph nodes evaluation is assessed by CT, MRI or lymphography. In stage IB, IIA and proximal IIB carcinoma, most patients will be operated and will have an intraoperative lymph node exploration and thus a surgical and clinico-pathological staging will be performed. In this case, clinical staging is often accurate. For larger tumors, radiological exploration will be more thorough for an optimal determination of the tumoral stage. (authors). 72 refs.

Ternier, F.; Rosello, R.; Stefano-Louineau, D. Di.; Le Brigand, B.; Mouillac, G.; Resbeut, M. [Institut Paoli-Calmettes, 13 - Marseille (France); Kind, M. [Fondation Bergonie, 33 - Bordeaux (France)

1997-09-01

150

Tendência da mortalidade por câncer do útero no Município de São Paulo entre 1980 e 1999 Mortality trends from uterine cervical cancer in the city of São Paulo from 1980 to 1999  

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Full Text Available O câncer do colo do útero apresenta grande incidência em algumas cidades brasileiras e considerável mortalidade em países em desenvolvimento, não obstante a disponibilidade já antiga de teste de rastreamento. O presente estudo visou avaliar a tendência da mortalidade por câncer de colo do útero, de corpo do útero e por câncer do útero não especificado, no Município de São Paulo, entre 1980 e 1999, por meio do exame das taxas brutas, idade-específica e ajustadas por idade. Os resultados mostraram discreta redução da mortalidade por câncer do colo do útero, queda da mortalidade por câncer de útero não especificado e aumento da mortalidade por câncer do corpo do útero. Conclui-se que a queda da mortalidade por câncer do útero não especificado sinaliza uma melhora na precisão do diagnóstico clínico e na qualidade do preenchimento do atestado de óbito, e indica aumento de cobertura do teste de Papanicolaou.Uterine cervical cancer shows a higher incidence in some Brazilian cities. It is a common cause of death in women from developing countries, despite the longstanding availability of an effective screening test, the Pap smear. This study aimed to evaluate the temporal trends of crude, age-adjusted, and age-specific mortality rates from cervical cancer, endometrial cancer, and cancer of the uterus not otherwise specified (NOS in the city of São Paulo from 1980 to 1999. Results showed a slight reduction in cervical cancer rates, a decrease in NOS uterine cancer rates, and an increase in endometrial cancer mortality rates. The fall in mortality from NOS uterine cancer indicates an improvement in diagnostic accuracy and quality of information on death certificates and may point to an increase in coverage of cervical cancer screening using the Pap smear.

Luiz Augusto Marcondes Fonseca

2004-02-01

151

Mulheres vivenciando o adoecer em face do câncer cérvico-uterino Mujeres que viven la experiencia de enfermedad en la presencia de cáncer cervical-uterino Women living the experience of illness in the presence of cervical-uterine cancer  

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Full Text Available O câncer cérvico-uterino é uma doença de alta incidência e prevalência no país. Com este estudo objetivou-se compreender as vivências de mulheres em face do processo de adoecer por câncer cérvico-uterino. Estudo descritivo exploratório realizado durante o primeiro trimestre de 2002 em serviço de referência ao atendimento de neoplasias de Fortaleza-CE. Foram pesquisadas vinte mulheres com câncer cérvico-uterino mediante entrevista semi-estruturada, cujas respostas foram assim categorizadas: 1. barreiras que dificultaram a prevenção; 2. enfrentamentos: da consulta ao diagnóstico de câncer; 3. desconhecimento sobre a evolução da doença; e 4. apego às pessoas e à religiosidade. Segundo evidenciaram os resultados, a maioria era proveniente do interior do Estado, com idade entre 30 e 50 anos; 75% possuíam ensino médio; 85% viviam com um a dois salários mínimos e 45% não haviam realizado o Papanicolaou. Diante da doença, indicaram sentimentos como ansiedade, medo e pânico. Também referiram desinformação e disseram recorrer à religião como estratégia para enfrentar o câncer. Alguns fatores de risco foram mencionados, sobressaindo: ausência e não adesão ao exame preventivo, convívio com escassos recursos socioeconômicos e dificuldades de acesso aos serviços de saúde.El cáncer cervical-uterino es una enfermedad de incidencia alta y predominio en Brasil. El objetivo del estudio presente era entender qué mujeres experimentan al enfrentar el proceso de volverse la deuda enferma al cáncer cervical-uterino. Un estudio exploratorio descriptivo se llevó a cabo en el primer trimestre de 2002 a una referencia repare para el cuidado de cáncer en Fortaleza-CE. Se investigaron veinte mujeres con el cáncer cervical-uterino por medio de una entrevista semi-estructurada, con las contestaciones a categorizándose como sigue: 1. barreras que dañan la prevención; 2. cubriendo: de la visita al diagnóstico de cáncer; 3. falte de conocimiento sobre el curso de la enfermedad; y 4. la atadura a las personas y a la religiosidad. Los resultados mostraron que la mayoría de las mujeres era del interior del Estado y era 30 a 50 años viejo; 75% tenían la media educación escolar; 85% vivieron encendido a dos salario mínimo, y 45% no habían sometido a una prueba de Papanicolaou. Al enfrentar la enfermedad, ellos indicaron sentimientos de ansiedad, miedo y pánico. Ellos también informaron falta de información y declararon que ellos se repitieron a la religión como una estrategia cubrir con el cáncer. Algunos factores de riesgo fueron mencionados, el más importante entre ellos: la ausencia de un examen preventivo o falta de complacencia con él, viviendo con las personas de recursos socio-económicos escasos, y dificultad de acceso a los servicios de salud.Cervical-uterine cancer is a disease of high incidence and prevalence in Brazil. The objective of the present study was to understand what women experience when facing the process of becoming ill due to cervical-uterine cancer. A descriptive exploratory study was carried out in the first trimester of 2002 at a reference service for cancer care in Fortaleza-CE. Twenty women with cervical-uterine cancer were investigated by means of a semi-structured interview, with the responses being categorized as follows: 1. barriers that impair prevention; 2. coping: from the visit to the diagnosis of cancer; 3. lack of knowledge about the course of the disease; and 4. attachment to people and to religiosity. The results showed that most women were from the interior of the State and were 30 to 50 years old; 75% had middle school education; 85% lived on one to two minimum wages, and 45% had not submitted to a Papanicolaou test. When facing the disease, they indicated feelings of anxiety, fear and panic. They also reported lack of information and stated that they recurred to religion as a strategy to cope with cancer. Some risk factors were mentioned, the most important among them: absence of a preventive examination or lack of compliance wi

Mariza Silva de Oliveira

2005-06-01

152

Mulheres vivenciando o adoecer em face do câncer cérvico-uterino / Women living the experience of illness in the presence of cervical-uterine cancer / Mujeres que viven la experiencia de enfermedad en la presencia de cáncer cervical-uterino  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O câncer cérvico-uterino é uma doença de alta incidência e prevalência no país. Com este estudo objetivou-se compreender as vivências de mulheres em face do processo de adoecer por câncer cérvico-uterino. Estudo descritivo exploratório realizado durante o primeiro trimestre de 2002 em serviço de ref [...] erência ao atendimento de neoplasias de Fortaleza-CE. Foram pesquisadas vinte mulheres com câncer cérvico-uterino mediante entrevista semi-estruturada, cujas respostas foram assim categorizadas: 1. barreiras que dificultaram a prevenção; 2. enfrentamentos: da consulta ao diagnóstico de câncer; 3. desconhecimento sobre a evolução da doença; e 4. apego às pessoas e à religiosidade. Segundo evidenciaram os resultados, a maioria era proveniente do interior do Estado, com idade entre 30 e 50 anos; 75% possuíam ensino médio; 85% viviam com um a dois salários mínimos e 45% não haviam realizado o Papanicolaou. Diante da doença, indicaram sentimentos como ansiedade, medo e pânico. Também referiram desinformação e disseram recorrer à religião como estratégia para enfrentar o câncer. Alguns fatores de risco foram mencionados, sobressaindo: ausência e não adesão ao exame preventivo, convívio com escassos recursos socioeconômicos e dificuldades de acesso aos serviços de saúde. Abstract in spanish El cáncer cervical-uterino es una enfermedad de incidencia alta y predominio en Brasil. El objetivo del estudio presente era entender qué mujeres experimentan al enfrentar el proceso de volverse la deuda enferma al cáncer cervical-uterino. Un estudio exploratorio descriptivo se llevó a cabo en el pr [...] imer trimestre de 2002 a una referencia repare para el cuidado de cáncer en Fortaleza-CE. Se investigaron veinte mujeres con el cáncer cervical-uterino por medio de una entrevista semi-estructurada, con las contestaciones a categorizándose como sigue: 1. barreras que dañan la prevención; 2. cubriendo: de la visita al diagnóstico de cáncer; 3. falte de conocimiento sobre el curso de la enfermedad; y 4. la atadura a las personas y a la religiosidad. Los resultados mostraron que la mayoría de las mujeres era del interior del Estado y era 30 a 50 años viejo; 75% tenían la media educación escolar; 85% vivieron encendido a dos salario mínimo, y 45% no habían sometido a una prueba de Papanicolaou. Al enfrentar la enfermedad, ellos indicaron sentimientos de ansiedad, miedo y pánico. Ellos también informaron falta de información y declararon que ellos se repitieron a la religión como una estrategia cubrir con el cáncer. Algunos factores de riesgo fueron mencionados, el más importante entre ellos: la ausencia de un examen preventivo o falta de complacencia con él, viviendo con las personas de recursos socio-económicos escasos, y dificultad de acceso a los servicios de salud. Abstract in english Cervical-uterine cancer is a disease of high incidence and prevalence in Brazil. The objective of the present study was to understand what women experience when facing the process of becoming ill due to cervical-uterine cancer. A descriptive exploratory study was carried out in the first trimester o [...] f 2002 at a reference service for cancer care in Fortaleza-CE. Twenty women with cervical-uterine cancer were investigated by means of a semi-structured interview, with the responses being categorized as follows: 1. barriers that impair prevention; 2. coping: from the visit to the diagnosis of cancer; 3. lack of knowledge about the course of the disease; and 4. attachment to people and to religiosity. The results showed that most women were from the interior of the State and were 30 to 50 years old; 75% had middle school education; 85% lived on one to two minimum wages, and 45% had not submitted to a Papanicolaou test. When facing the disease, they indicated feelings of anxiety, fear and panic. They also reported lack of information and stated that they recurred to religion as a strategy to cope with cancer. So

Mariza Silva de, Oliveira; Ana Fátima Carvalho, Fernandes; Marli Teresinha Gimeniz, Galvão.

2005-06-01

153

Is the adaptive tomography of cervical carcinomas necessary?; La tomotherapie adaptative des carcinomes du col uterin est-elle necessaire?  

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The authors report the study of the macroscopic tumour volume (GTV, gross tumour volume) and its possible repercussion on organs at risk during a tomo-therapy with an additional concomitant centro-pelvic irradiation. Ten women with non-operable cervical carcinomas have been treated by tomo-therapy and chemotherapy. A high-energy conical tomography has been performed before each session. Data obtained from these tomographies have been used in the adaptive therapy module of a tomo-therapy planimetry software. It appears that there is no evidence of significant variations of doses at the level of organs at risk with the use of such software. Short communication

Le Tinier, F.; Nickers, P.; Reynaert, N.; Castelain, B.; Lacornerie, T.; Attar, M.; Lartigau, E. [Centre Oscar-Lambret, 59 - Lille (France)

2010-10-15

154

Multi-institutional study of radiation therapy for isolated para-aortic lymph node recurrence in uterine cervical carcinoma: 84 subjects of a population of more than 5,000  

International Nuclear Information System (INIS)

Purpose: Most patients who had any recurrent sites of cancer have been considered to be in their last stage of life. However, recent advances of clinical research reveal some patients achieve long-term survival even in recurrence. Furthermore, for patients who had only one recurrent region, radiation therapy could play an important role. As for uterine cervical carcinoma, the most common recurrent site other than the pelvis is the para-aortic lymph nodes. Thus we conducted the current study. Patients and Methods: Between 1994 and 2003, more than 5,000 uterine cervical carcinoma patients were treated with curative intended treatments at 13 Japanese hospitals. Of these patients, 84 developed para-aortic lymph node recurrence as the only site of initial tumor progression. These patients were treated with external beam radiation therapy. Radiation therapy protocol was as follows: 1.7-2.0 Gy per fraction, 5 fractions per week, and the mean total dose was 50.8 Gy (25-60 Gy). Results: Three- and 5-year overall survival rates of all patients were 49.5% and 31.3%, respectively. Stratified by symptom sign, 3-year overall survival rate of symptom positive was 27.6% and those of the negative was 56.1% (p = 0.018). Three-year overall survival rates of the total dose ?51 Gy and that of ?50 Gy were 58.0% and 42.8%, respectively (p = 0.07). As for morbidity, no patients received Grade 3 or greater late toxicity. Conclusions: The current study suggested that radiation therapy for suggested that radiation therapy for isolated para-aortic lymph node recurrence in uterine cervical carcinoma could have a significant impact on survival

155

Ganglio centinela para estadios tempranos en cáncer de cuello uterino / Sentinel lymph node detection in early uterine cervical cancer  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Objetivo: Determinar la factibilidad y seguridad del ganglio centinela (GC) con el uso combinado del mapeo linfático con Tc 99 y la inyección de colorante azul (patent blue) en pacientes con cáncer de cérvix temprano sometidas a histerectomía radical con linfadenectomía pélvica bilateral. Diseño: Es [...] tudio prospectivo. Institución: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú. Participantes: Pacientes con cáncer temprano de cuello uterino. Intervenciones: Entre diciembre de 2003 y diciembre de 2006, 66 pacientes con cáncer temprano de cuello estadios IA2 (n=2), IB1 (n=63) y IIA (n=1) fueron sometidas a detección del ganglio linfático centinela con linfoscintigrafía el día previo a la operación y mapeo linfático intraoperatorio con colorante azul y sonda detectora de radiación gama. El tratamiento quirúrgico se completó con la realización de la histerectomía radical y linfadenectomía pélvica bilateral, por laparotomía. Principales medidas de resultados: Detección de ganglios centinelas. Resultados: En las 66 pacientes estudiadas se detectó 136 ganglios centinelas, con un promedio de 2,06 por paciente. Se utilizó el método combinado (Tc 99 y patent blue). La localización más frecuente fue la región obturatriz con un 69,9% (n=95). Se halló metástasis en los ganglios pélvicos en 11 pacientes, que fueron correctamente localizadas en el ganglio centinela con una sensibilidad de 100%. Cuando el ganglio centinela fue negativo, no se encontró metástasis en los ganglios no centinela (VPN 100%). Conclusiones: La identificación del ganglio centinela con tecnecio-99 combinado con la inyección de colorante azul es factible y mostró un valor predictivo negativo de 100%. Abstract in english Objective: To determine sentinel node (SN) detection feasibility and safety by using lymphatic mapping with 99m Tc Dextrán and injection of blue dye (patent blue) in patients with early cervical cancer undergoing radical hysterectomy with bilateral pelvic lymphadenectomy. Design: Prospective study. [...] Setting: Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru. Participants: Patients with early cervical cancer. Interventions: Between December 2003 and December 2006, 66 patients with early cervical cancer stages IA2 (n = 2), IB1 (n = 63) and IIA (n = 1) underwent sentinel lymph node detection with lymphoscintigraphy the day before operation and intraoperative lymphatic mapping with blue dye and gamma radiation detection probe. Surgical treatment was completed with radical hysterectomy and bilateral pelvic lymphadenectomy by laparotomy. Main outcome measures: Sentinel node detection. Results: One hundred and thirty-six sentinel nodes were detected in all 66 patients, average 2.06 per patient, by using the combined method 99m Tc dextrán and patent blue. Most common location was the obturator region in 69.9% of cases (n = 95). Pelvic lymph node metastases were found by the sentinel node in 11 patients (sensitivity of 100%). In negative sentinel node cases (55 patients) no metastases were encountered (negative predictive value, NPV = 100%). Conclusions: Sentinel node identification using 99m technetium Dextrán and blue dye injection is feasible and had a negative predictive value of 100%.

Henry, Valdivia; Rossana, Morales; Luis, Taxa; Manuel, Álvarez; Carlos, Santos; Albert, Zevallos; Carlos, Velarde; Marco, Sánchez; Aldo, López; Absalón, Montoya.

156

Citologia oncológica, captura de híbridos II e inspeção visual no rastreamento de lesões cervicais Pap smear, hybrid capture II, and visual inspection in screening for uterine cervical lesions  

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Full Text Available Avaliar as alterações na citologia oncológica, na captura híbrida II e na inspeção visual com ácido acético (IVA a 5% em 684 mulheres atendidas em uma unidade de saúde, e avaliar o desempenho e a concordância entre os exames. Procurar descrever as características sócio-demográficas e reprodutivas (SDR destas mulheres e sua associação com a presença de doença. As mulheres foram submetidas à coleta de citologia, captura e IVA, e as com exame positivo foram submetidas à colposcopia com biopsia, se necessário. Foi calculado o desempenho dos testes e a associação dos fatores SDR com o diagnóstico histológico foi avaliada por intermédio do cálculo do odds ratio. Embora 198 mulheres apresentassem pelo menos um teste alterado, apenas 21 apresentaram lesão histológica. A sensibilidade dos testes foi semelhante enquanto as especificidades da IVA e da citologia foram maiores que a da captura híbrida II. Apenas a ausência de citologia esteve associada à presença de doença. O desempenho da citologia foi maior que o da IVA, que foi maior que o da captura. A ausência de citologia foi associada com doença histológica.The objective of this study was to evaluate alterations in Pap smear, hybrid capture II (HCII, and visual inspection with acetic acid (VIA in 684 women treated at a primary health care unit. The performance and agreement of the exams were evaluated. The study also described social, demographic, and reproductive factors and their association with uterine cervical lesions. Women had specimens taken for Pap smear, HCII, and VIA. When at least one of the tests was positive, colposcopy was performed and targeted biopsies were taken from any suspicious lesions. Performance of tests was evaluated. Women's distribution in relation to social, demographic, and reproductive factors and histological diagnosis was evaluated using the odds ratio. Among 198 women with at least one positive screening test, only 21 showed histological disease. Sensitivities of the tests were similar. VIA and Pap smear presented higher specificity than HCII. Only absence of a previous Pap smear was associated with the presence of histological disease. Pap smear performed better than VIA and HC II. Absence of previous cytology was associated with histological disease.

Renata Clementino Gontijo

2005-02-01

157

Radioterapia: percepção de mulheres com câncer cérvico-uterino / Radiotherapy: perception of women with uterine-cervical cancer / Radioterapia: percepción de mujeres con cáncer cérvico-uterino  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Realizou-se um estudo qualitaitvo com objetivo de conhecer a percepção das mulheres com câncer cérvico-uterino sobre a radioterapia, descrevendo as alterações físicas e cotidianas sofridas e evidenciando meios de enfrentamento e expectativas em relação ao tratamento. Foram entrevistadas 20 mulheres [...] em um hospital especializado, localizado na cidade de Teresina-PI. Os resultados mostraram que elas percebem a radioterapia como um bom tratamento, apesar do medo diante do desconhecido e das limitações no cotidiano, devido aos efeitos colaterais, que são enfrentados com suporte na religiosidade e no âmbito sócio-familiar, aumentando a expectativa de cura. Revelou-se a importância da orientação a essas mulheres pela equipe multiprofissional, especialmente o Enfermeiro, em todas as fases do tratamento. Abstract in spanish Se realizó un estudio con abordaje cualitativo objetivando conocer la percepción de las mujeres con cáncer cérvico-uterino sobre la radioterapia, describiendo las alteraciones físicas y cotidianas sufridas y evidenciando el medio utilizado para que enfrenten esas adversidades y sus expectativas con [...] relación al tratamiento. Fueron entrevistadas 20 mujeres en un hospital especializado, localizado en la ciudad de Teresina-PI. Los resultados mostraron que ellas perciben la radioterapia como un buen tratamiento, a pesar del miedo delante de lo desconocido y de las limitaciones en el cotidiano, debido a los efectos colaterales, que son enfrentados con base en la religiosidad y en el ámbito socio-familiar, aumentando la expectativa de cura. Se reveló la importancia de la orientación a esas mujeres por el equipo multiprofesional, especialmente el Enfermero, en todas las fases del tratamiento. Abstract in english This is a qualitiative study that aimed to know the perception of women with uterine-cervical cancer on the radiotherapy, describing the physical and daily alterations they suffered and evidencing the their coping to face these adversities and their expectations about the treatment. 20 women in a sp [...] ecialized hospital had been interviewed, located in the city of Teresina-PI. The results showed that they perceive the radiotherapy as a good treatment, although the fear ahead of the stranger and the limitations in the daily one, had to the side-effects, that are faced with support in the religious and the social-familiar scope, increasing the cure expectation. The importance of the orientation to these women for the multiprofessional team showed, especially the Nurse, in all the phases of the treatment.

Lúcia Helena Rios Barbosa de, Almeida; Yarla Brena Araújo de Sousa, Pereira; Thais Alexandre de, Oliveira.

2008-08-01

158

PET in uterine malignancies  

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Full Text Available Positron Emission Tomography (PET or integrated PET/Computed Tomography (PET/CT with 18F-Fluoro-Deoxy-Glucose (18F-FDG is a functional imaging modality, useful in the characterization of undetermined morphological findings, and in the staging/re-staging of a large number of malignancies. Although its use in uterine malignancies has been poorly investigated, in recent years the employment of this technique has constantly increased. In this review, we evaluate the role of PET (/CT with 18FFDG in uterine malignancies (cervical and endometrial cancers as well as uterine sarcomas, underlying its advantages and discussing its limitations. Metabolic and anatomic information given by PET/CT with 18F-FDG could be useful in the evaluation of local and distant disease involvement at the staging, in the detection of disease recurrence, and in the evaluation of the response after chemotherapy and/or radio-therapy.

Valeria Pirro

2010-07-01

159

Spontaneous uterine rupture at 32 weeks of gestation after previous uterine artery embolization.  

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Uterine artery embolization (UAE) is a common treatment for post-partum hemorrhage and uterine fibroids. However, the effects of UAE on subsequent pregnancies have not been established. Here, we present a case of spontaneous uterine rupture after previous UAE. A 31-year-old woman underwent UAE for a cervical ectopic pregnancy. Contrast-enhanced magnetic resonance imaging (MRI) at days 5 and 25 post-UAE suggested a regionally decreased blood supply in the mid-posterior wall of the uterine fundus. During a subsequent pregnancy at age 35 years, she underwent an emergency cesarean delivery due to spontaneous uterine rupture at the mid-posterior wall of the uterus at 32 weeks of gestation. Obstetricians should be attentive to the possibility of spontaneous uterine rupture in pregnant women who have previously undergone UAE. Detection of ischemic uterine muscle on MRI may predict potential for uterine rupture in a subsequent pregnancy. PMID:23945024

Takeda, Jun; Makino, Shintaro; Ota, Atsuyuki; Tawada, Tetsuo; Mitsuhashi, Naoki; Takeda, Satoru

2014-01-01

160

Uterine Fibroids  

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Full Text Available Uterine Fibroids Introduction Fibroids are common, benign tumors of the uterus. They can cause significant pain, as well as ... located above and behind the vagina and uterus. Fibroids Uterine fibroids are benign tumors in the middle ...

 
 
 
 
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A percepção da mulher sobre o exame preventivo do câncer cérvico-uterino: estudo de caso Women's perceptions of preventive examinations for cervical-uterine cancer: a case study  

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Full Text Available O câncer cérvico-uterino é uma das doenças crônico-degenerativas mais temidas, em razão do seu alto grau de letalidade e morbidade. Nesse sentido, realizamos um estudo para descrever a percepção das mulheres ante o exame de prevenção de câncer cérvico-uterino. Optamos por um estudo de caso tendo a observação e a entrevista semi-estruturada como técnicas de coleta das informações. Foram entrevistadas vinte e quatro mulheres, entre 18 e 60 anos, que buscaram o serviço de prevenção em uma unidade básica de saúde de Fortaleza-CE, entre abril e agosto de 2004. O estudo revelou que a mulher geralmente só procura fazer o exame de prevenção quando surgem sintomas, por ter vivenciado este exame com apreensão e medo pela possibilidade de um diagnóstico positivo de um câncer cérvico-uterino; sente-se constrangida em expor seu corpo e tê-lo examinado, sobretudo, quando o profissional de saúde é do sexo masculino; não tem conhecimento do corpo e tampouco de sua sexualidade. Esse resultado aponta para a necessidade de o profissional de saúde desenvolver atividades educativas junto às mulheres, no sentido de melhorar a relação profissional de saúdeusuária e, conseqüentemente, diminuir a incidência deste tipo de câncer, pela maior freqüência aos exames de prevenção.Cervical-uterine cancer is among the most feared chronic degenerative diseases, due its high mortality and morbidity rates. This study describes women's feelings before a preventive examination for cervical-uterine cancer, through a case study based on observations and semi-structured interviews as data collection techniques. A total of 24 women were interviewed, between eighteen and sixty years old, who attended the cancer prevention unit at a basic healthcare clinic in Fortaleza, Ceará State between April and August 2004. This study shows that women generally request these preventive examinations only when symptoms appear. They view this procedure with apprehension and fear, due to the possibility of a positive diagnosis of cervical-uterine cancer; they feel embarrassed at exposing their bodies for examination, particularly by male physicians; and they are poorly informed about their own bodies and even their own sexuality. These findings highlight the need for healthcare practitioners to conduct educational activities for women, in order to enhance professional relationships between healthcare providers and users, helping lower the rate of this type of cancer through more frequent preventive examinations.

Lucélia Maria Duavy

2007-06-01

162

Micronúcleos em células do colo uterino em mulheres HIV+ segundo sua condição de imunidade Micronuclei in uterine cervical cells of women HIV+ according to immunocompetence markers  

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Full Text Available OBJETIVO: investigar a micronucleação (MN em células esfoliadas do colo uterino de mulheres HIV+ observando as condições de imunidade aferidas pelos níveis de linfócitos CD4+ e da carga viral para o HIV (CV. MÉTODOS: foram obtidas coletas citológicas da junção escamocolunar de 23 pacientes HIV+ de Ambulatório de DST/AIDS. O grupo controle foi composto por mulheres assintomáticas do Ambulatório de Prevenção de Câncer Ginecológico do mesmo serviço. O material foi submetido a processamento citológico para leitura em microscopia de luz, com objetiva de imersão em 2.000 células por paciente. Para avaliação da condição imunitária das pacientes HIV+ investigamos os níveis de linfócitos CD4+ e CV. A análise estatística dos resultados se fez com os testes do ?2 e Kolmogorov-Smirnov. RESULTADOS: vinte e três pacientes compuseram o grupo de mulheres HIV+ e 19 formaram o grupo controle. Em todas as pacientes HIV+ e em 84,2% do grupo controle detectamos MN. Dezessete pacientes HIV+ (73,9% tiveram mais de 7 MN. No grupo controle tivemos apenas 1 caso (5,2% com mais de 7 MN. Houve tendência na associação de maiores quantidades de MN em mulheres com baixos níveis de linfócitos CD4+ e maiores níveis de CV, sem caracterizar correlação estatística. CONCLUSÕES: pacientes HIV+ em fase de AIDS têm maior ocorrência de MN que o grupo controle e, também, a frequência com que são detectados MN parece estar associada a piores condições clínicas da imunossupressão.PURPOSE: to investigate the micronucleation (MN of exfoliated cells from the uterine cervix of HIV+ women according to immunocompetence status. We investigated the clinical conditions of immunocompetence by analyzing the levels of CD4+ lymphocytes and viral count for HIV (VC. METHODS: biological material was collected from 23 HIV+ patients whose cervical oncologic cytology results were negative. They were patients from the STD/AIDS-FCMS-PUCSP who underwent a cytobrush collection in the squamous columnar junction. Similar material was obtained from 19 healthy control women. The material, about 2000 cells per patient, was processed for cytology using light microscopy and an immersion objective. To analyze the immunological status of HIV+ patients we used CD4+ count and VC. Statistical analysis was performed using the ?2 and Kolmorogov-Smirnov tests. RESULTS: twenty-three pacients composed the group of HIV+ women and 19 composed the control group. We found micronuclei (MN in all HIV+ patients and in 84.2% of the control group. In 17 73.9% of the HIV+ patients and in 5.2% of the control group we found more than 7 MN cells. MN tended to occur more among women with poorer immunological status in the HIV+ group. CONCLUSIONS: HIV+ patients in the AIDS phase have a higher prevalence of micronucleated cells, as opposed to a control group. Also, the frequency of MN was associated with worse conditions of immunosuppression.

Camila Figueira Mendes

2011-10-01

163

Uterine factors.  

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Uterine anomalies are one of the most common parental causes of recurrent pregnancy loss, occurring in about 19% of patients. Congenital uterine anomalies are most likely caused by HOX gene mutations, although the mechanism is probably polygenic. There are no known environmental causes other than estrogenic endocrine disruptors such as diethylstilbestrol. Acquired uterine anomalies may result from uterine trauma (adhesions) or benign growths of the myometrium (fibroids) or endometrium (polyps). Although randomized controlled trials are lacking, surgical treatment is recommended for repair of uterine septa, and for removal of severe adhesions and submucosal fibroids, especially if no other causes are identified. PMID:24491984

Jaslow, Carolyn R

2014-03-01

164

Evaluación del seguimiento de mujeres con cáncer cervicouterino en dos policlínicos. Pinar del Río / Follow-up assessment of women suffering from cervical uterine cancer in two polyclinics, Pinar del Rio  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: A pesar de contar con un programa de detección precoz del cáncer cervicouterino de larga duración aún no se logran los resultados esperados. Objetivo: Caracterizar a las pacientes con cáncer invasor del cuello uterino en dos áreas de salud de Pinar del Río en el quinquenio 2003-2007. M [...] aterial y Método: Estudio observacional, transversal, de cohorte, retrospectivo de mujeres de cualquier edad con diagnóstico de cáncer cervicouterino invasor. La información de las pacientes se tomó de los registros automatizados de las lesiones de cuello uterino de la consulta provincial de Patología de Cuello, del Provincial de Cáncer (Dirección Provincial de Salud), y del de Mortalidad General (Dirección Provincial de Salud) así como de las historias clínicas de la Unidad Oncológica Provincial. Entre las variables estudiadas estuvieron si procedían o no del programa, edad, estadio clínico, tratamiento recibido, incidencia anual y el promedio en la etapa, la mortalidad y la letalidad. Resultados: Se encontró que el 70,6% de casos no se detectó por programa. La tasa de incidencia promedio fue 29.5 por 100000 mujeres de 15 años y más. Todas las pacientes recibieron el tratamiento oncoespecífico según estadio clínico. Las mayores tasas de mortalidad se encontraron en las pacientes en estadio IIIB al diagnóstico. Conclusiones: Se detectan fallas en la Atención Primaria de Salud, por falta de detección. Las tasas de incidencia de esta enfermedad no se han logrado disminuir. Y se siguen diagnosticando casos en estadios avanzados de la enfermedad, lo que acorta la sobrevida de estas pacientes. Abstract in english Introduction: Despite of having a program, for a long time, to the early detection of cervical uterine cancer, the results expected are not as far achieved. Objective: to characterize the patients suffering from invasive cervical uterine cancer in two health areas in Pinar del Rio province throughou [...] t five years (2003-2007). Material and Methods: observational, cross-sectional, cohort, retrospective study including women at every age with invasive cervical-uterine cancer. The information concerning the patients was collected from the automated records of cervical uterine at the provincial office for cervix pathology treatment (Provincial Public Health Direction), general death rate (Provincial Public Health Direction) and from the clinical histories of the Provincial Cancer Unit. Among the variables studied were: coming or not from the program, age, clinical stage, treatment followed, and annual incidence, together with the average of mortality and lethality considering the clinical stages. Results: 70,6% of the cases were not detected by the program. The average incidence rate was 29.5 per 10 0000 women from 15 years old or older. All patients underwent to a specific cancer treatment according to the clinical stage. The greatest mortality rates were found in patients presenting IIIB stage at diagnosis. Conclusion: errors were observed in Primary Health Care leading to deficiencies in the early detection of this type cancer. The incidence rates of this disease have not diminished; cases suffering from advanced stages of the disease are still detected, shortening the survival rate of these patients.

José Guillermo, Sanabria Negrín; Inalvis de la Caridad, Cruz Hernández; Leonardo, Oriolo Pérez; Miguel Angel, Pérez Herrera; Beatriz, Valdés Abreu.

2012-06-01

165

Evaluación del seguimiento de mujeres con cáncer cervicouterino en dos policlínicos. Pinar del Río Follow-up assessment of women suffering from cervical uterine cancer in two polyclinics, Pinar del Rio  

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Full Text Available Introducción: A pesar de contar con un programa de detección precoz del cáncer cervicouterino de larga duración aún no se logran los resultados esperados. Objetivo: Caracterizar a las pacientes con cáncer invasor del cuello uterino en dos áreas de salud de Pinar del Río en el quinquenio 2003-2007. Material y Método: Estudio observacional, transversal, de cohorte, retrospectivo de mujeres de cualquier edad con diagnóstico de cáncer cervicouterino invasor. La información de las pacientes se tomó de los registros automatizados de las lesiones de cuello uterino de la consulta provincial de Patología de Cuello, del Provincial de Cáncer (Dirección Provincial de Salud, y del de Mortalidad General (Dirección Provincial de Salud así como de las historias clínicas de la Unidad Oncológica Provincial. Entre las variables estudiadas estuvieron si procedían o no del programa, edad, estadio clínico, tratamiento recibido, incidencia anual y el promedio en la etapa, la mortalidad y la letalidad. Resultados: Se encontró que el 70,6% de casos no se detectó por programa. La tasa de incidencia promedio fue 29.5 por 100000 mujeres de 15 años y más. Todas las pacientes recibieron el tratamiento oncoespecífico según estadio clínico. Las mayores tasas de mortalidad se encontraron en las pacientes en estadio IIIB al diagnóstico. Conclusiones: Se detectan fallas en la Atención Primaria de Salud, por falta de detección. Las tasas de incidencia de esta enfermedad no se han logrado disminuir. Y se siguen diagnosticando casos en estadios avanzados de la enfermedad, lo que acorta la sobrevida de estas pacientes.Introduction: Despite of having a program, for a long time, to the early detection of cervical uterine cancer, the results expected are not as far achieved. Objective: to characterize the patients suffering from invasive cervical uterine cancer in two health areas in Pinar del Rio province throughout five years (2003-2007. Material and Methods: observational, cross-sectional, cohort, retrospective study including women at every age with invasive cervical-uterine cancer. The information concerning the patients was collected from the automated records of cervical uterine at the provincial office for cervix pathology treatment (Provincial Public Health Direction, general death rate (Provincial Public Health Direction and from the clinical histories of the Provincial Cancer Unit. Among the variables studied were: coming or not from the program, age, clinical stage, treatment followed, and annual incidence, together with the average of mortality and lethality considering the clinical stages. Results: 70,6% of the cases were not detected by the program. The average incidence rate was 29.5 per 10 0000 women from 15 years old or older. All patients underwent to a specific cancer treatment according to the clinical stage. The greatest mortality rates were found in patients presenting IIIB stage at diagnosis. Conclusion: errors were observed in Primary Health Care leading to deficiencies in the early detection of this type cancer. The incidence rates of this disease have not diminished; cases suffering from advanced stages of the disease are still detected, shortening the survival rate of these patients.

José Guillermo Sanabria Negrín

2012-06-01

166

6 Common Cancers - Gynecologic Cancers Cervical, Endometrial, and Ovarian  

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... 6 Common Cancers - Gynecologic Cancers Cervical, Endometrial, and Ovarian Past Issues / Spring 2007 Table of Contents For ... turn Javascript on. Gynecologic Cancers Cervical, Endometrial, and Ovarian NCI estimates that endometrial, or uterine, cancer will ...

167

Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile / Detection and genotyping of human papillomavirus in biopsies of uterine cervical adenocarcinoma  

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Full Text Available SciELO Chile | Language: Spanish Abstract in spanish [...] Abstract in english Background: The genotyping of Human Papillomavirus (HPV) will improve knowledge about the local epidemiological association of this virus with adenocarcinoma. Aim: To determine the frequency of HPV genotypes in biopsies of women with uterine cervical adenocarcinoma in a geographic region of Chile. M [...] aterials and Methods: Forty-one cervical biopsies with a pathological diagnosis of adenocarcinoma, corresponding to all women diagnosed with this cancer between 2002 and 2004, were analyzed. Viral gene Ll was amplified by PCRfor viral detection. HPV genotyping was carried out by a Reverse Line Blot technique. Results: Seventy one percent of biopsies were positive for HPV. The most common genotypes found were HPV 16 (61%), followed by HPV 18 (19.5%). Eighty seven percent of biopsies had a single HPV infection. Three patients had a multiple HPV infection. All of the latter were infected by HPV 16, associated with other three viral genotypes (45, 52 and 66). No low-risk HPV genotypes were found. Conclusions: In this sample of biopsies, there was a high prevelence of HPV 16 and a low prevalence of HPV 18, which historically has been related to adenocarcinoma. The genotypes found correspond to those described in South America.

Priscilla, Brebi M; Carmen Gloria, Ili G; Jaime, López M; Patricia, García M; Angélica, Melo A; Sonia, Montenegro H; Pamela, Leal R; Pablo, Guzmán G; Juan Carlos, Roa S.

168

Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile / Detection and genotyping of human papillomavirus in biopsies of uterine cervical adenocarcinoma  

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Full Text Available SciELO Chile | Language: Spanish Abstract in spanish [...] Abstract in english Background: The genotyping of Human Papillomavirus (HPV) will improve knowledge about the local epidemiological association of this virus with adenocarcinoma. Aim: To determine the frequency of HPV genotypes in biopsies of women with uterine cervical adenocarcinoma in a geographic region of Chile. M [...] aterials and Methods: Forty-one cervical biopsies with a pathological diagnosis of adenocarcinoma, corresponding to all women diagnosed with this cancer between 2002 and 2004, were analyzed. Viral gene Ll was amplified by PCRfor viral detection. HPV genotyping was carried out by a Reverse Line Blot technique. Results: Seventy one percent of biopsies were positive for HPV. The most common genotypes found were HPV 16 (61%), followed by HPV 18 (19.5%). Eighty seven percent of biopsies had a single HPV infection. Three patients had a multiple HPV infection. All of the latter were infected by HPV 16, associated with other three viral genotypes (45, 52 and 66). No low-risk HPV genotypes were found. Conclusions: In this sample of biopsies, there was a high prevelence of HPV 16 and a low prevalence of HPV 18, which historically has been related to adenocarcinoma. The genotypes found correspond to those described in South America.

Priscilla, Brebi M; Carmen Gloria, Ili G; Jaime, López M; Patricia, García M; Angélica, Melo A; Sonia, Montenegro H; Pamela, Leal R; Pablo, Guzmán G; Juan Carlos, Roa S.

2009-03-01

169

Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile Detection and genotyping of human papillomavirus in biopsies of uterine cervical adenocarcinoma  

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Full Text Available Background: The genotyping of Human Papillomavirus (HPV will improve knowledge about the local epidemiological association of this virus with adenocarcinoma. Aim: To determine the frequency of HPV genotypes in biopsies of women with uterine cervical adenocarcinoma in a geographic region of Chile. Materials and Methods: Forty-one cervical biopsies with a pathological diagnosis of adenocarcinoma, corresponding to all women diagnosed with this cancer between 2002 and 2004, were analyzed. Viral gene Ll was amplified by PCRfor viral detection. HPV genotyping was carried out by a Reverse Line Blot technique. Results: Seventy one percent of biopsies were positive for HPV. The most common genotypes found were HPV 16 (61%, followed by HPV 18 (19.5%. Eighty seven percent of biopsies had a single HPV infection. Three patients had a multiple HPV infection. All of the latter were infected by HPV 16, associated with other three viral genotypes (45, 52 and 66. No low-risk HPV genotypes were found. Conclusions: In this sample of biopsies, there was a high prevelence of HPV 16 and a low prevalence of HPV 18, which historically has been related to adenocarcinoma. The genotypes found correspond to those described in South America.

Priscilla Brebi M

2009-03-01

170

Uterine Cancer  

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... sheet about uterine cancer is part of the Centers for Disease Control and Prevention’s (CDC) Inside Knowledge: Get the Facts About Gynecologic ... more information about uterine and other gynecologic cancers? Centers for Disease Control and Prevention: 1-800-CDC-INFO or www.cdc.gov/ ...

171

Evolution of uterine cervical cancer mortality from 1979 to 1998 in the State of Rio Grande do Sul, Brazil A evolução da mortalidade por câncer de colo de útero entre 1979 e 1998 no Rio Grande do Sul, Brasil  

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Full Text Available A decrease in uterine cervical cancer (CC mortality has been observed in developed countries. However, mortality data in Brazil suggest that CC is one of the most frequent causes of cancer death in women; it is the fourth cause of death from cancer in women in Rio Grande Sul State. A time-trend ecological study was performed to analyze CC mortality trends in Rio Grande do Sul from 1979 to 1998. Data were collected from the Mortality Information System, Brazilian Ministry of Health (DATASUS. Standardized mortality ratios were calculated and linear regression was used for time-trend analysis. The impact of cervical cancer death on life expectancy was also estimated for the study population using potential years of life lost (PYLL. Standardized mortality ratios during the study period revealed a positive linear trend of 0.17, and the mean annual mortality rate was 7.58/100,000. Cervical cancer accounted for 21.9 ± 1.33 PYLL during the period. In conclusion, although CC is a preventable and curable disease, an increase is observed in mortality from this cause in Rio Grande do Sul State, which may suggest failure in screening programs for cervical cancer.A mortalidade por câncer de colo de útero tem diminuído em países desenvolvidos. Entretanto, no Brasil, os dados apontam o câncer de colo de útero como uma das mais freqüentes causas de morte por neoplasia em mulheres, estando em quarto lugar no Rio Grande Sul. Este estudo do tipo série-temporal analisa a mortalidade por câncer de colo de útero e a evolução deste fenômeno no Rio Grande do Sul, no período entre 1979 e 1998. Os dados foram extraídos do Sistema de Informação sobre Mortalidade. Coeficientes de mortalidade padronizados foram analisados por meio de regressão linear simples. Estimou-se o impacto da mortalidade por esta causa sobre a duração de vida esperada para esta população utilizando-se o cálculo dos Anos Potenciais de Vida Perdidos (APVP. Observou-se uma tendência linear positiva dos coeficientes de mortalidade padronizados com incremento anual de 0,17, e o coeficiente anual médio dos óbitos no período foi de 7,58/ 100 mil. Esta doença foi responsável por uma média de 21,9±1,33 APVP. Assim, apesar do câncer de colo de útero ser uma doença prevenível e curável, observa-se um aumento de mortalidade por esta causa, sugerindo falhas nos programas de rastreamento desta doença.

Luciane Kalakun

2005-02-01

172

Evolution of uterine cervical cancer mortality from 1979 to 1998 in the State of Rio Grande do Sul, Brazil / A evolução da mortalidade por câncer de colo de útero entre 1979 e 1998 no Rio Grande do Sul, Brasil  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: English Abstract in portuguese A mortalidade por câncer de colo de útero tem diminuído em países desenvolvidos. Entretanto, no Brasil, os dados apontam o câncer de colo de útero como uma das mais freqüentes causas de morte por neoplasia em mulheres, estando em quarto lugar no Rio Grande Sul. Este estudo do tipo série-temporal ana [...] lisa a mortalidade por câncer de colo de útero e a evolução deste fenômeno no Rio Grande do Sul, no período entre 1979 e 1998. Os dados foram extraídos do Sistema de Informação sobre Mortalidade. Coeficientes de mortalidade padronizados foram analisados por meio de regressão linear simples. Estimou-se o impacto da mortalidade por esta causa sobre a duração de vida esperada para esta população utilizando-se o cálculo dos Anos Potenciais de Vida Perdidos (APVP). Observou-se uma tendência linear positiva dos coeficientes de mortalidade padronizados com incremento anual de 0,17, e o coeficiente anual médio dos óbitos no período foi de 7,58/ 100 mil. Esta doença foi responsável por uma média de 21,9±1,33 APVP. Assim, apesar do câncer de colo de útero ser uma doença prevenível e curável, observa-se um aumento de mortalidade por esta causa, sugerindo falhas nos programas de rastreamento desta doença. Abstract in english A decrease in uterine cervical cancer (CC) mortality has been observed in developed countries. However, mortality data in Brazil suggest that CC is one of the most frequent causes of cancer death in women; it is the fourth cause of death from cancer in women in Rio Grande Sul State. A time-trend eco [...] logical study was performed to analyze CC mortality trends in Rio Grande do Sul from 1979 to 1998. Data were collected from the Mortality Information System, Brazilian Ministry of Health (DATASUS). Standardized mortality ratios were calculated and linear regression was used for time-trend analysis. The impact of cervical cancer death on life expectancy was also estimated for the study population using potential years of life lost (PYLL). Standardized mortality ratios during the study period revealed a positive linear trend of 0.17, and the mean annual mortality rate was 7.58/100,000. Cervical cancer accounted for 21.9 ± 1.33 PYLL during the period. In conclusion, although CC is a preventable and curable disease, an increase is observed in mortality from this cause in Rio Grande do Sul State, which may suggest failure in screening programs for cervical cancer.

Luciane, Kalakun; Mary Clarisse, Bozzetti.

173

Evolution of uterine cervical cancer mortality from 1979 to 1998 in the State of Rio Grande do Sul, Brazil / A evolução da mortalidade por câncer de colo de útero entre 1979 e 1998 no Rio Grande do Sul, Brasil  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese A mortalidade por câncer de colo de útero tem diminuído em países desenvolvidos. Entretanto, no Brasil, os dados apontam o câncer de colo de útero como uma das mais freqüentes causas de morte por neoplasia em mulheres, estando em quarto lugar no Rio Grande Sul. Este estudo do tipo série-temporal ana [...] lisa a mortalidade por câncer de colo de útero e a evolução deste fenômeno no Rio Grande do Sul, no período entre 1979 e 1998. Os dados foram extraídos do Sistema de Informação sobre Mortalidade. Coeficientes de mortalidade padronizados foram analisados por meio de regressão linear simples. Estimou-se o impacto da mortalidade por esta causa sobre a duração de vida esperada para esta população utilizando-se o cálculo dos Anos Potenciais de Vida Perdidos (APVP). Observou-se uma tendência linear positiva dos coeficientes de mortalidade padronizados com incremento anual de 0,17, e o coeficiente anual médio dos óbitos no período foi de 7,58/ 100 mil. Esta doença foi responsável por uma média de 21,9±1,33 APVP. Assim, apesar do câncer de colo de útero ser uma doença prevenível e curável, observa-se um aumento de mortalidade por esta causa, sugerindo falhas nos programas de rastreamento desta doença. Abstract in english A decrease in uterine cervical cancer (CC) mortality has been observed in developed countries. However, mortality data in Brazil suggest that CC is one of the most frequent causes of cancer death in women; it is the fourth cause of death from cancer in women in Rio Grande Sul State. A time-trend eco [...] logical study was performed to analyze CC mortality trends in Rio Grande do Sul from 1979 to 1998. Data were collected from the Mortality Information System, Brazilian Ministry of Health (DATASUS). Standardized mortality ratios were calculated and linear regression was used for time-trend analysis. The impact of cervical cancer death on life expectancy was also estimated for the study population using potential years of life lost (PYLL). Standardized mortality ratios during the study period revealed a positive linear trend of 0.17, and the mean annual mortality rate was 7.58/100,000. Cervical cancer accounted for 21.9 ± 1.33 PYLL during the period. In conclusion, although CC is a preventable and curable disease, an increase is observed in mortality from this cause in Rio Grande do Sul State, which may suggest failure in screening programs for cervical cancer.

Luciane, Kalakun; Mary Clarisse, Bozzetti.

174

Benefits of MRI in planning curie therapy of cervical cancers; Interets de l'IRM dans la planification de curietherapie des cancers du col uterin  

Energy Technology Data Exchange (ETDEWEB)

As image-guided curie-therapy of cervical cancers is an always more used technique, the authors report a comparison of the contours of anatomo-clinic target volumes as they are defined by scanography and MRI. It appears that the first one overestimates the target volumes, while MRI improves the volume definition and allows treated volumes to be reduced. Short communication

Peignaux, K.; Petitfils, A.; Truc, G.; Martin, E.; Chamois, J.; Ligey-Bartolomeu, A.; Crehange, G.; Maingon, P. [Centre Georges Francois Leclerc, 21 - Dijon (France); Guiu, B.; Krause, D. [CHU du Bocage, 21 - Dijon (France)

2010-10-15

175

Magnetic resonance imaging of cancer of uterine cervix and body. Preliminary study in 9 cases of body cancer and 20 of cervical cancer  

International Nuclear Information System (INIS)

We studied nine cases of endometrial carcinoma and twenty of cervix carcinoma. Correlation with histology is made after curietherapy in 8 cases of endometrial carcinoma. Tumor is not always seen and particularly when there is no mass effect on macroscopic examination. Myometral invasion is not seen with accuracy: the interruption of junctional zone is not a good sign. The cervix tumors are well seen on T2 sequences before any treatment. There extra uterine extension is difficult to appreciate. The best results of RMI were in the follow-up after radiotherapy. Therefore it appears actually to us the best indication of RMI

176

Uterine Fibroids  

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Full Text Available ... and do not require treatment other than regular observation by a doctor. For women who experience occasional ... surgery. It is an alternative to leiomyomectomy, hysterectomy, watchful waiting, hormone therapy, or uterine fibroid embolization. FUA uses ...

177

Uterine Fibroids  

Medline Plus

Full Text Available ... well as abnormal bleeding. About 30% of all women may have fibroids. Most of them do not ... may be discovered during a routine examination. Some women who have uterine fibroids may experience symptoms, such ...

178

Uterine Fibroids  

Medline Plus

Full Text Available ... periods • A feeling of fullness in the lower abdomen Other symptoms of uterine fibroids include: • Frequent urination ... the uterus through a small incision in the abdomen to destroy the blood vessels feeding the fibroids. ...

179

Uterine Fibroids  

Medline Plus

Full Text Available ... Uterine fibroids are made of nodules of smooth muscle cells and fibrous tissue that develop in the ... may experience symptoms, such as: • Excessive or painful bleeding during menstruation • Bleeding between periods • A feeling of ...

180

Uterine Fibroids  

Medline Plus

Full Text Available ... intend to become pregnant. FUA is a non-invasive surgery. It is an alternative to leiomyomectomy, hysterectomy, watchful waiting, hormone therapy, or uterine fibroid embolization. ...

 
 
 
 
181

Uterine Fibroids  

Medline Plus

Full Text Available ... Myolysis • Uterine Fibroid Embolization or UFE • Focused Ultrasound Ablation Myolysis Myolysis is a procedure in which an ... Last reviewed: 09/20/2013 5 Focused Ultrasound Ablation or FUA Focused Ultrasound Ablation uses focused ultrasounds ...

182

Uterine Fibroids  

Science.gov (United States)

Uterine fibroids are the most common benign tumors in women of childbearing age. Fibroids are made of muscle cells and other tissues ... of the uterus, or womb. The cause of fibroids is unknown. Risk factors include being African American ...

183

Uterine Fibroids  

Science.gov (United States)

... ways to perform endometrial ablation. • Uterine artery embolization (UAE)—In this procedure, tiny particles (about the size ... to the fibroid and cause it to shrink. UAE can be performed as an outpatient procedure in ...

184

Uterine Fibroids  

Medline Plus

Full Text Available ... focused ultrasounds that are guided by magnetic resonance images to target and destroy uterine fibroids. The procedure is intended to treat women who have completed child bearing or do not ...

185

Uterine Fibroids  

Medline Plus

Full Text Available ... uses focused ultrasounds that are guided by magnetic resonance images to target and destroy uterine fibroids. The ... a device that combines two systems – a magnetic resonance imaging (MRI) machine to visualize patient anatomy, map ...

186

Uterine Fibroids  

Medline Plus

Full Text Available ... cells and fibrous tissue that develop in the wall of the uterus. Fibroids may grow as a ... in diameter. Uterine fibroids may grow in the wall of the uterus, or they may project into ...

187

Uterine Fibroids  

Medline Plus

Full Text Available ... Ablation uses focused ultrasounds that are guided by magnetic resonance images to target and destroy uterine fibroids. ... uses a device that combines two systems – a magnetic resonance imaging (MRI) machine to visualize patient anatomy, ...

188

Preliminary Experience with Locoregional Intraarterial Chemotherapy of Uterine Cervical or Endometrial Cancer Using the Peripheral Implantable Port System (PIPSTM): A Feasibility Study  

International Nuclear Information System (INIS)

The purpose of this study was to assess the suitability of a percutaneously implantable catheter port system (PIPS)for repeated intraarterial locoregional chemotherapy (ILC) for cervical and endometrial carcinoma. In 30 patients with advanced, recurrent, or high-risk cervical (n 23) or endometrial(n = 7) carcinoma, PIPS for ILC was implanted via a femoral access, the catheter localized in the infrarenal abdominal aorta. Chemotherapy was performed adjuvantly after surgery(n = 14) or neo-adjuvantly to enable surgery, or for palliation (n = 16). Port implantation, catheter placement, and repeated port puncture was uneventful in all patients.Complications included catheter dislocation (n = 1),catheter thrombosis (n = 2), subcutaneous infection(n = 1), port-bed skin atrophy (n = 1),requiring port explantation in 3 patients. At 2 years follow-up,complete remission was observed in 7/14 patients with adjuvant chemotherapy, partial remission in 3/14. Successful down-staging could be achieved in 4/8 patients with neo-adjuvant chemotherapy. The PIPS is suitable for repeated ILC which may be a valuable method for pre- and post-surgical therapy of advanced or high-risk cervical and endometrial cancer, for adjuvant chemotherapy as well as neo-adjuvantly for down-staging, or for palliation

189

Lesões precursoras do câncer cervicouterino: evolução histórica e subsídios para consulta de enfermagem ginecológica / Cervical-uterine cancer precursor lesions: historical evolution supporting the gynecological nursing consultation / Lesiones precursoras del cáncer cervical-útero: evolución histórica consolidando la consulta de enfermería ginecológica  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Estudo emergido de recorte de dissertação de mestrado, ilustrando a evolução histórica das lesões precursoras do câncer cervicouterino (LPCCU). Trata-se da história das LPCCU, delineando a relevância do conhecimento para prática do enfermeiro na área da saúde da mulher. O conceito de LPCCU inicia-se [...] a partir do século XIX, dando início aos estudos das células alteradas. Objetivo: descrever as diversas fases da evolução histórica das alterações cervicais. Estudo qualitativo, descritivo-analítico, recorte temporal no período de 1940 a 2008. Dados levantados mediante bibliografia de fonte primária e recurso BIREME. Pontuaram-se as classificações que já existiram, destacando a Nomenclatura Brasileira, importante para corresponder às necessidades e o perfil da saúde das mulheres do Brasil. Este estudo é o ponto de partida para respaldar as práticas de consulta de enfermagem ginecológica com abordagens educativas, contemplando a população feminina em ações preventivas e incentivo ao tratamento. Abstract in spanish Estudio emergido de recorte de disertación de máster, ilustrando la evolución histórica de las lesiones precursoras del cáncer cervical-uterino (LPCCU). Se trata de la historia de las LPCCU, delineando la relevancia del conocimiento para la práctica del enfermero en cuidados en la salud de la mujer. [...] El concepto de LPCCU se inicia a partir del siglo XIX, empezando los estudios de las células alteradas. Como objetivo: describir las diversas fases históricas de las alteraciones cervicales. Estudio cualitativo, descriptivo-analítico, recorte temporal en el período de 1940 hasta 2008. Datos acrecentados mediante bibliografía de fuente primaria y recurso BIREME. Se puntuó las diferentes clasificaciones que ya existieron, conde destaque para la nomenclatura brasileña, importante para corresponder a las necesidades y el perfil de la salud de las mujeres del Brasil. Esto estudio es el ponto de partida para respaldar las prácticas de consulta de enfermería ginecológica con abordajes educativas, contemplando la población femenina en acciones preventivas y incentivo al tratamiento. Abstract in english Study emerged from an article of the master degree that illustrates the phases of the historical evolution of the precursor lesions of the cervical-uterine cancer. Thus, it is a question of the history about, delineating the relevance of this knowledge for the nurse's practice in care in the woman's [...] health. The precursor lesions concept of the cervical-uterine cancer, initiates itself from the XIX century, beginning with studies of the cells altered. It had as objective: describe the diverse historical phases of the cervical-uterine cancer. A qualitative, descriptive-analytical study, using time cutting in the period of 1940 to 2008. The data were raised by means of bibliographical reference as primary spring and about the resource BIREME, By means of this study was possible to score the different classifications that already existed, highlighting the Brazilian Nomenclature was important to correspond the needs and the profile of the health of the women of Brazil. This study is the starting point to support the gynecological nursing consultation practices with educational approaches, contemplating the female population in preventive actions and incentive to the treatment.

Maria Cristina de Melo Pessanha, Carvalho; Ana Beatriz Azevedo, Queiroz.

190

Lesões precursoras do câncer cervicouterino: evolução histórica e subsídios para consulta de enfermagem ginecológica Lesiones precursoras del cáncer cervical-útero: evolución histórica consolidando la consulta de enfermería ginecológica Cervical-uterine cancer precursor lesions: historical evolution supporting the gynecological nursing consultation  

Directory of Open Access Journals (Sweden)

Full Text Available Estudo emergido de recorte de dissertação de mestrado, ilustrando a evolução histórica das lesões precursoras do câncer cervicouterino (LPCCU. Trata-se da história das LPCCU, delineando a relevância do conhecimento para prática do enfermeiro na área da saúde da mulher. O conceito de LPCCU inicia-se a partir do século XIX, dando início aos estudos das células alteradas. Objetivo: descrever as diversas fases da evolução histórica das alterações cervicais. Estudo qualitativo, descritivo-analítico, recorte temporal no período de 1940 a 2008. Dados levantados mediante bibliografia de fonte primária e recurso BIREME. Pontuaram-se as classificações que já existiram, destacando a Nomenclatura Brasileira, importante para corresponder às necessidades e o perfil da saúde das mulheres do Brasil. Este estudo é o ponto de partida para respaldar as práticas de consulta de enfermagem ginecológica com abordagens educativas, contemplando a população feminina em ações preventivas e incentivo ao tratamento.Estudio emergido de recorte de disertación de máster, ilustrando la evolución histórica de las lesiones precursoras del cáncer cervical-uterino (LPCCU. Se trata de la historia de las LPCCU, delineando la relevancia del conocimiento para la práctica del enfermero en cuidados en la salud de la mujer. El concepto de LPCCU se inicia a partir del siglo XIX, empezando los estudios de las células alteradas. Como objetivo: describir las diversas fases históricas de las alteraciones cervicales. Estudio cualitativo, descriptivo-analítico, recorte temporal en el período de 1940 hasta 2008. Datos acrecentados mediante bibliografía de fuente primaria y recurso BIREME. Se puntuó las diferentes clasificaciones que ya existieron, conde destaque para la nomenclatura brasileña, importante para corresponder a las necesidades y el perfil de la salud de las mujeres del Brasil. Esto estudio es el ponto de partida para respaldar las prácticas de consulta de enfermería ginecológica con abordajes educativas, contemplando la población femenina en acciones preventivas y incentivo al tratamiento.Study emerged from an article of the master degree that illustrates the phases of the historical evolution of the precursor lesions of the cervical-uterine cancer. Thus, it is a question of the history about, delineating the relevance of this knowledge for the nurse's practice in care in the woman's health. The precursor lesions concept of the cervical-uterine cancer, initiates itself from the XIX century, beginning with studies of the cells altered. It had as objective: describe the diverse historical phases of the cervical-uterine cancer. A qualitative, descriptive-analytical study, using time cutting in the period of 1940 to 2008. The data were raised by means of bibliographical reference as primary spring and about the resource BIREME, By means of this study was possible to score the different classifications that already existed, highlighting the Brazilian Nomenclature was important to correspond the needs and the profile of the health of the women of Brazil. This study is the starting point to support the gynecological nursing consultation practices with educational approaches, contemplating the female population in preventive actions and incentive to the treatment.

Maria Cristina de Melo Pessanha Carvalho

2010-09-01

191

Impact of curie-therapy timing in the treatment of cervical cancer; Impact du timing de la curietherapie dans le traitement du cancer du col uterin  

Energy Technology Data Exchange (ETDEWEB)

Curie-therapy conventionally comes before surgery in the treatment of cervical cancer, either alone or after a concomitant chemotherapy. The authors report a study of the impact of a reverse sequence (surgery before curie-therapy) on the exeresis quality and on the evolution of operable tumours. Among women treated between 2004 and 2009, 40 have been identified who had surgery before curie-therapy. Ages, tumour stages, average doses, and treatment procedures are discussed. The notably high rate of vaginal sections could be reduced or avoided by using the conventional protocol (curie-therapy before surgery). Short communication

Kochbati, L.; Bouzid, N.; Saidi, I.; Nasr, C.; Messai, T.; Hentati, D.; Gargouri, W.; Besbes, M.; Maalej, M. [Service de radiotherapie, institut Salah-Azaiz, Tunis (Tunisia)

2011-10-15

192

Efficacy of Cone Biopsy of the Uterine Cervix during Frozen Section for the Evaluation of Cervical High Grade Intraepithelial Neoplasia (CIN II-III  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction & Objectives: This study was performed to determine the role of frozen section examination (FSE of the cone specimen in the evaluation of the resection margin status and to rule out invasion in patients with high-grade cervical intraepithelial neoplasia.Materials & Methods: Twenty patients with high grade intraepithelial neoplasia undergoing conization biopsy and frozen section examination were cross- sectionally studied from March 2008 until September 2009.The results of permanent paraffin sections were compared using FSE.Results: In this cross-sectional study, 15 out of 20 cases (75% showed the same results in frozen and permanent sections of cone biopsy specimen. Two patients out of the remaining 5 ones had higher grade of CIN in frozen section, 2 had lower grade and one was considered the same because CIN1 in FSE was normal in permanent sections.although The Paired Sample t-test showed no significant difference between the two groups of frozen and permanent section results (P-value=0.716, CI=95%. Conclusion: Frozen section evaluation of cervical cone biopsy specimens in patients with CIN II-III is accurate, efficient, and cost-effective.

V. Titidej

2010-01-01

193

Explanation for the failure of neoadjuvant chemotherapy to improve outcomes after radiotherapy for locally advanced uterine cervical cancer from the standpoint of the tumor regression rate  

International Nuclear Information System (INIS)

Treatment outcomes for patients with locally advanced cervical cancer are no better with neoadjuvant chemotherapy (NAC) combined with radiotherapy (RT) than with RT alone. We investigated the reason for this failure from the standpoint of the tumor regression rate (RR). A total of 48 patients with clinical stage IIB-IVA cervical squamous cell carcinoma were treated clinically with cisplatin-based NAC plus RT (n=15) or RT alone (n=33). The RR was defined as the slope of a tumor shrinkage curve derived with magnetic resonance images. The local control rate (LCR) and disease-free rate (DFR) were estimated by clinical stage (IIB vs. III-IVA), pretreatment volume (?median vs. >median), lymph node status (negative vs. positive), treatment type, overall treatment time (?8 weeks vs. >8 weeks), and RR (?median vs. >median) using univariate and multivariate analyses. RR during NAC or during NAC and RT (n=15) was not significantly higher than RR by RT alone (n=33). Low RR and positive nodal status were significantly powerful prognostic factors for both the LCR and DFR, whereas the others were not. Although effective in reducing tumor volume prior to RT, NAC showed no overall effect in increasing the RR, which was shown to be the most powerful prognostic factor. (author)

194

Uterine Lesions  

Directory of Open Access Journals (Sweden)

Full Text Available Transvaginal color and pulsed Doppler ultrasound depicts the endometrium in great details. The texture and thicknessof the endometrium are indicators of endometrial development, while blood flow analysis may be used as a bioassay of the uterine receptivity. This method can non-invasively detect uterine anomalies, endometrial polyps,submucous leiomyomas, intrauterine adhesions and other uterine causes that can lead to poor reproductive performance. Vascularization of the uterine tumors, if used together with analysis of morphology and size, can increase our accuracy in differentiation between uterine sarcoma and leiomyoma. It seems that the multiparameter sonographic approach, which includes morphology and size depicted by transvaginal ultrasonography and color flow imaging withpulsed Doppler analysis of neovascular signals,can help in diagnosis of uterine sarcoma in high-risk groups such as postmenopausal patients with a rapidly enlarging uterus. Therefore, serial measurements are recommended for evaluation of the myometrial density, follow-up of the tumoral growth, and detection of the impedance to blood flow.Only such complex observations can lead to proper diagnosis of these rare tumors with unpredictable prognosis. The application of transvaginal color Doppler to the postmenopausal population for screening of endometrial carcinoma may be a viable option if combined with ovarian screening in the same scan. In this way, the capital costs would be shared, and an oncological preventive medicine for women could be created. The use of this technique could also result in a reduction in dilatation and curettage operations with considerable saving of both the potential risks and economic costs of the operation.

A. Kurjak

2005-08-01

195

Camp based awareness and screening programme of cervical cancer in rural area of Bangladesh.  

Science.gov (United States)

This population based cross sectional study was carried out in Muktagacha Upazilla Health Complex, Mymensingh, Bangladesh during the period of 26th to 28th June, 2012. The objective was to create awareness, to find out the precancerous lesion of cervix and to evaluate the effectiveness of this approach for prevention of cervical carcinoma. Women who were married and between 30-60 years and also women of below 30 years (who were married below the age of 18) were included in this study. All pregnant women were excluded from this study. After counseling, pelvic examination and VIA (visual inspection of cervix with application of 5% acetic acid) test was done. If the squamo-columner junction of cervix turned to white then it was called VIA positive (+ve) cases. Then they were referred to colposcopy clinic of Mymensingh Medical College with a red card for evaluation and management. During the 3 days campaign, 395 cases were examined. Among them, majority (49%) of the women were below the age of 30. It was observed that still 48.2% were married below the age of 18 and 31% had first pregnancy at an age or below 18 years. But number of grand multiparity is lowering now a days. Only 25% had para ?4. Others have para 1-3. During pelvic examination, the common cervico-uterine pathologies like chronic cervicities (16.5%), cervical erosion (14.4%), uterine prolapse (2.3%), cervical polyp (1%), myomatous polyp (0.3%) and advanced cervical carcinoma (0.5%) were also diagnosed clinically. Among the participants, 11.9% was detected as VIA+ve cases. A significant association of VIA+ve cases with low socio-economic conditions, hindu religion, early age at marriage and high parity were observed in this study (p<0.05). The findings of this study highlight the utility and need of camp based cervical cancer screening service at regular interval in the community. PMID:24292289

Shahida, S M; Saha, K; Banu, K A; Islam, M A

2013-10-01

196

Percepção da vulnerabilidade entre mulheres com diagnóstico avançado do câncer do colo do útero / Perceiving vulnerability among women with advanced diagnosis of uterine cervical cancer / La percepción de la vulnerabilidad entre mujeres con diagnóstico de cáncer cervical avanzado  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Estudo descritivo, de abordagem qualitativa, que objetivou compreender a percepção da vulnerabilidade à doença, entre mulheres com diagnóstico avançado do câncer do colo do útero, tendo como referencial, a vulnerabilidade. Participaram doze mulheres que estavam em atendimento ambulatorial hospitalar [...] , para tratamento do câncer cérvico-uterino avançado. Os dados foram coletados por entrevistas e analisados por Análise de Conteúdo. Dos resultados emergiram duas categorias temáticas: Percebendo-se vulnerável na descoberta da doença e Percebendo-se vulnerável na realização do tratamento. Fatores relacionados à cliente, profissionais, serviços, entre outros, tornaram a mulher suscetível aos problemas e danos de saúde, relativos ao câncer cérvico-uterino, exacerbando sua vulnerabilidade à doença. É necessário superar deficiências no modelo de assistência e humanização do atendimento, no grau de compromisso e qualidade das instituições, dos recursos, gerenciamento e monitoramento dos programas de prevenção e detecção do câncer do colo do útero, nos diferentes níveis de atenção. Abstract in spanish Este estudio descriptivo y cualitativo tuvo como objetivo comprender la percepción de la vulnerabilidad a la enfermedad, entre las mujeres diagnosticadas con cáncer cervical avanzado, tomando como referencia la vulnerabilidad. Participaron doce mujeres que recibían atención ambulatoria hospitalaria [...] para el tratamiento del cáncer cervico uterino avanzado. La recolección de los datos se hizo a través de entrevistas y se analizaron mediante el análisis de contenido. Los resultados destacan dos temas: Percepción de su vulnerabilidad al descubrir la enfermedad, y percepción de su vulnerabilidad al realizar el tratamiento. Factores relacionados con el cliente, los servicios, los profesionales, entre otros, han hecho que las mujeres sean susceptibles a los problemas de salud y daños relacionados con el cáncer cervico uterino, lo que agrava su vulnerabilidad a las enfermedades. Es necesario superar las deficiencias en el modelo de tratamiento para el cuidado y la integridad personal, el grado de compromiso y calidad de las instituciones, recursos, programas de gestión y control para prevenir y detectar el cáncer del cuello uterino, en los diferentes niveles de atención. Abstract in english This descriptive qualitative study aimed to comprehend perceptions of vulnerability to disease among women diagnosed with advanced cervical cancer. Twelve women who were receiving outpatient hospital care in treating advanced cervical cancer participated in the study. Data was collected through inte [...] rviews and analyzed via content analysis. The results highlight two themes: Perceiving oneself as vulnerable in discovering the disease; and Perceiving oneself vulnerable in carrying out treatment. Factors related to the client, health care professionals, and services rendered, among others have made women susceptible to health problems and damage relating to cervical cancer, exacerbating their vulnerability to the disease. It is necessary to overcome deficiencies in care model and the humanization of treatment, the degree of commitment, as well as the quality of institutions, resources, management and monitoring programs towards preventing and detecting cervical cancer within different levels of care.

Angela Vieira, Pimentel; Marislei Sanches, Panobianco; Ana Maria de, Almeida; Iácara Santos Barbosa, Oliveira.

197

Insufficiency Fractures After Pelvic Radiation Therapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG)  

International Nuclear Information System (INIS)

Purpose: To investigate pelvic insufficiency fractures (IF) after definitive pelvic radiation therapy for early-stage uterine cervical cancer, by analyzing subjects of a prospective, multi-institutional study. Materials and Methods: Between September 2004 and July 2007, 59 eligible patients were analyzed. The median age was 73 years (range, 37-84 years). The International Federation of Gynecologic Oncology and Obstetrics stages were Ib1 in 35, IIa in 12, and IIb in 12 patients. Patients were treated with the constant method, which consisted of whole-pelvic external-beam radiation therapy of 50 Gy/25 fractions and high-dose-rate intracavitary brachytherapy of 24 Gy/4 fractions without chemotherapy. After radiation therapy the patients were evaluated by both pelvic CT and pelvic MRI at 3, 6, 12, 18, and 24 months. Diagnosis of IF was made when the patients had both CT and MRI findings, neither recurrent tumor lesions nor traumatic histories. The CT findings of IF were defined as fracture lines or sclerotic linear changes in the bones, and MRI findings of IF were defined as signal intensity changes in the bones, both on T1- and T2-weighted images. Results: The median follow-up was 24 months. The 2-year pelvic IF cumulative occurrence rate was 36.9% (21 patients). Using Common Terminology Criteria for Adverse Events version 3.0, grade 1, 2, and 3 IF were seen in 12 (21%), 6 (10%), and 3 patients (5%), respectively. Sixteen patients had multiple fractures, so IF were idents had multiple fractures, so IF were identified at 44 sites. The pelvic IF were frequently seen at the sacroileal joints (32 sites, 72%). Nine patients complained of pain. All patients' pains were palliated by rest or non-narcotic analgesic drugs. Higher age (>70 years) and low body weight (<50 kg) were thought to be risk factors for pelvic IF (P=.007 and P=.013, Cox hazard test). Conclusions: Cervical cancer patients with higher age and low body weight may be at some risk for the development of pelvic IF after pelvic radiation therapy.

198

Insufficiency Fractures After Pelvic Radiation Therapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG)  

Energy Technology Data Exchange (ETDEWEB)

Purpose: To investigate pelvic insufficiency fractures (IF) after definitive pelvic radiation therapy for early-stage uterine cervical cancer, by analyzing subjects of a prospective, multi-institutional study. Materials and Methods: Between September 2004 and July 2007, 59 eligible patients were analyzed. The median age was 73 years (range, 37-84 years). The International Federation of Gynecologic Oncology and Obstetrics stages were Ib1 in 35, IIa in 12, and IIb in 12 patients. Patients were treated with the constant method, which consisted of whole-pelvic external-beam radiation therapy of 50 Gy/25 fractions and high-dose-rate intracavitary brachytherapy of 24 Gy/4 fractions without chemotherapy. After radiation therapy the patients were evaluated by both pelvic CT and pelvic MRI at 3, 6, 12, 18, and 24 months. Diagnosis of IF was made when the patients had both CT and MRI findings, neither recurrent tumor lesions nor traumatic histories. The CT findings of IF were defined as fracture lines or sclerotic linear changes in the bones, and MRI findings of IF were defined as signal intensity changes in the bones, both on T1- and T2-weighted images. Results: The median follow-up was 24 months. The 2-year pelvic IF cumulative occurrence rate was 36.9% (21 patients). Using Common Terminology Criteria for Adverse Events version 3.0, grade 1, 2, and 3 IF were seen in 12 (21%), 6 (10%), and 3 patients (5%), respectively. Sixteen patients had multiple fractures, so IF were identified at 44 sites. The pelvic IF were frequently seen at the sacroileal joints (32 sites, 72%). Nine patients complained of pain. All patients' pains were palliated by rest or non-narcotic analgesic drugs. Higher age (>70 years) and low body weight (<50 kg) were thought to be risk factors for pelvic IF (P=.007 and P=.013, Cox hazard test). Conclusions: Cervical cancer patients with higher age and low body weight may be at some risk for the development of pelvic IF after pelvic radiation therapy.

Tokumaru, Sunao, E-mail: tokumaru@cc.saga-u.ac.jp [Department of Heavy Particle Therapy and Radiation Oncology, Saga University, Saga (Japan); Toita, Takafumi [Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa (Japan); Oguchi, Masahiko [Radiation Oncology Department, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo (Japan); Ohno, Tatsuya [Gunma University Heavy Ion Medical Center, Maebashi (Japan); Kato, Shingo [Department of Radiation Oncology, Saitama Medical University, International Medical Center, Saitama (Japan); Niibe, Yuzuru [Department of Radiology, School of Medicine, Kitasato University, Sagamihara (Japan); Kazumoto, Tomoko [Department of Radiology, Saitama Cancer Center, Saitama (Japan); Kodaira, Takeshi [Department of Radiation Oncology, Aichi Cancer Center, Nagoya (Japan); Kataoka, Masaaki [Department of Radiology, National Shikoku Cancer Center, Matsuyama (Japan); Shikama, Naoto [Department of Radiation Oncology, Saitama Medical University, International Medical Center, Saitama (Japan); Kenjo, Masahiro [Department of Radiation Oncology, Graduate School of Medical Science, Hiroshima University, Hiroshima (Japan); Yamauchi, Chikako [Department of Radiation Oncology, Shiga Medical Center for Adults, Moriyama (Japan); Suzuki, Osamu [Department of Radiation Oncology, Osaka Medical Center for Cancer, Osaka (Japan); Sakurai, Hideyuki [Proton Medical Research Center and Tsukuba University, Tuskuba (Japan); Teshima, Teruki [Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Suita (Japan); Kagami, Yoshikazu [Department of Radiology, Showa University School of Medicine, Tokyo (Japan); Nakano, Takashi [Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi (Japan); Hiraoka, Masahiro [Department of Radiation Oncology and Image-applied Therapy, Kyoto University, Graduate School of Medicine, Kyoto (Japan); and others

2012-10-01

199

Uterine Fibroids  

Medline Plus

Full Text Available ... periods • A feeling of fullness in the lower abdomen Other symptoms of uterine fibroids include: • Frequent urination resulting from a fibroid that presses on the bladder • Pain during sexual intercourse • Low back pain Complications In rare cases, a fibroid may press on ...

200

Uterine Fibroids  

Medline Plus

Full Text Available ... to have them at an earlier age. Athletic women seem to have a lower prevalence of uterine fibroids than women who do not ... you to go into early menopause. Too few women have gotten pregnant after UFE for researchers to know if there ...

 
 
 
 
201

Uterine Fibroids  

Medline Plus

Full Text Available ... focused ultrasounds that are guided by magnetic resonance images to target and destroy uterine fibroids. The procedure is intended to treat women who have completed child bearing or do not intend to become pregnant. FUA is a non-invasive surgery. It is ...

202

High-dose-rate intra-cavitary brachytherapy combined with external beam radiation therapy for under 40-year-old patients with invasive uterine cervical carcinoma. Clinical outcomes in 118 patients in a Japanese multi-institutional study, JASTRO  

International Nuclear Information System (INIS)

The current study was designed to evaluate the clinical outcomes of curative intent radiation therapy for young patients with invasive uterine cervical carcinoma in Japan. One hundred and eighteen patients aged ?40 were registered in the multi-institutional study of the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) from 26 major institutions in Japan. The age range was 24-39 years and the maximum tumor diameter was 2.0-9.2 cm. The International Federation of Gynecology and Obstetrics clinical stages were Ib, IIa, IIb, IIIa, IIIb and IVa in 17, 6, 40, 2, 50 and 3, respectively. Curative intent radiation therapy consisted of the combination of external beam radiation therapy and high-dose rate intra-cavitary brachytherapy. The total dose of external beam radiation therapy ranged between 44 and 68 Gy. Both the median and mode of total high-dose-rate intra-cavitary brachytherapy dose to point A were 24 Gy in four fractions. Ninety-six patients (58%) received chemotherapy. The 5-year overall survival rate and local control rate of all patients were 61 and 65%, respectively. The 5-year overall survival rates of International Federation of Gynecology and Obstetrics Stage Ib, IIa, IIb, IIIa, IIIb and IVa were 88, 100, 75, 100, 37 and 0%, respectively. The 5-year local control rates of International Federation of Gynecology and Obstetrics Stage Ib, IIa, IIb, IIIa, IIIb and IVa were 82, 75, 75, 100, 51 and 0%, respectively. Sixteen patients experienced grade 3 or greater late radiation morbidity. The 5-year overall survival rate of young patients with Stage IIIb was comparatively low at 37%. (author)

203

Node-by-node correlation between MR and PET/CT in patients with uterine cervical cancer: diffusion-weighted imaging versus size-based criteria on T2WI  

International Nuclear Information System (INIS)

The purpose of the study was to perform a node-by-node comparison of an ADC-based diagnosis and various size-based criteria on T2-weighted imaging (T2WI) with regard to their correlation with PET/CT findings in patients with uterine cervical cancer. In 163 patients with 339 pelvic lymph nodes (LNs) with short-axis diameter >5 mm, the minimum apparent diffusion coefficient (ADC), mean ADC, short- and long-axis diameters, and ratio of long- to short-axis diameters (L/S ratio) were compared in PET/CT-positive and -negative LNs. On PET/CT, 118 (35%) LNs in 58 patients were positive. The mean value of minimum and mean ADCs, short- and long-axis diameters, and L/S ratio were different in PET/CT-positive (0.6436 x 10-3 mm2/s, 0.756 x 10-3 mm2/s, 10.3 mm, 13.2 mm, 1.32, respectively) and PET/CT-negative LNs (0.8893 x 10-3 mm2/s, 1.019 x 10-3 mm2/s, 7.4 mm, 11.0 mm, 1.49, respectively) (P<0.05). The Az value of the minimum ADC (0.864) was greater than those of mean ADC (0.836), short-axis diameter (0.764), long-axis diameter (0.640) and L/S ratio (0.652) (P<0.05). The sensitivity and accuracy of the minimum ADC (86%, 82%) were greater than those of the short-axis diameter (55%, 74%), long-axis diameter (73%, 58%) and L/S ratio (52%, 66%) (P<0.05). ADC showed superior correlation with PET/CT compared with conventional size-based criteria on T2WI. (orig.)ig.)

204

Extreme cervical elongation  

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Full Text Available Uterine prolapse is a condition which has commonly affected women of all times. The problem of genital prolapse and its remedies is described in the oldest medical literature, the Egyptian Papyri. The normal length of the cervix is about 2.5 cm. The vaginal and supravaginal parts are of equal length. The elongation may affect either part of the cervix. The length of the uterocervical canal is measured by introduction of the uterine sound. Cervical elongation plays an important role in deciding the surgical treatment. We had a case of extreme cervical elongation and we faced difficulties during the surgery. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 777-779

Hiremath PB

2014-06-01

205

Combined radiation and chemotherapy for locally advanced cervical cancer: preliminary study; Radio-chimiotherapie concomitante dans les cancers du col uterin localement avances: etude preliminaire  

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We have designed a combined treatment strategy of bifractionated split course radiotherapy (RT) and concomitant chemotherapy (CT) to try to improve the results of RT in inoperable cervical carcinoma. After evaluation, patients were submitted to further radical surgery or additional RT-CT depending on the treatment results. Between January 1992, 25 patients with non metastatic inoperable disease entered in the protocol. The stage of the disease was: T{sub 3}N{sub 0}4 patients, T{sub 3} with hydronephrosis seven patients, T{sub 3}N{sub 1} 12 patients, and T{sub 4}N{sub 0} two patients. Nineteen patients received two courses of CT with fluorouracil (F), cisplatin (P) with or without etoposide. Pelvic RT was given twice daily (two fractions of 3 Gy) on days 1, 3, 15 and 17. A combination of F 400 mg/m{sup 2}/d and P 15 mg/m{sup 2}/d in continuous infusion with oral etoposide (100 mg/d) and hydroxyurea (500 mg/d) in 11 patients was delivered concomitantly on days 1-3 and 14-17. A clinical and radiological evaluation was performed four weeks later. Patients with objective response underwent radical hysterectomy (group A) and those with incomplete response received additional RT-CT protocol (group B). All patients had endocavitary brachytherapy at the end of treatment. After two cycles of CT there were four PR in 19 patients and 5 failures. (authors). 36 refs., 1 fig.

Delanian, S.; Housset, M.; Maulard-Durdux, C. [Hopital Saint-Louis, 75 - Paris (France); Taurelle, R.; Lecuru, F. [Hopital boucicaut, 75 - Paris (France); Baillet, F. [Hopital Pitie-Salpetriere, 75 - Paris (France)

1995-12-31

206

A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy  

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Full Text Available Abstract Purpose We assessed the value of dose-volumetric parameters predicting rectosigmoid mucosal changes (RMC and late rectosigmoid complications (LRC. Methods Between January 2004 and February 2006, 77 patients with stage IB-IIIB cervical cancer underwent external beam radiotherapy and computed tomography (CT-based intracavitary irradiation. Total dose to the rectal point and several dose-volumetric parameters for rectosigmoid colon (D20cc, D15cc, D10cc, D5cc, D2cc, D1cc, and D0.1cc , defined as the minimal doses received by the highest irradiated volumes of 20, 15, 10, 5, 2, 1, and 0.1 cc, respectively, were calculated using the equivalent dose in 2 Gy fractions (?/??=?3, Gy3. The RMC and LRC were graded by rectosigmoidoscopy and Radiation Therapy Oncology Group criteria every 6 months, respectively. Results Of 77 patients, 27 (35.1% patients developed RMC???score 3 and 22 (28.6 % patients developed LRC???grade 2. There was a positive correlation between RMC score and LRC grade (r?=?0.728, p?5cc, among the dose-volumetric parameters, was significant parameter for the risks of RMC???score 3 and LRC???grade 2 (p??0.05. Conclusions D5cc may be a more reliable estimate than other dose-volumetric parameters for predicting the risk of RMC???score 3 and LRC???grade 2 in CT-based brachytherapy.

Kim Tae Hyun

2013-01-01

207

Intracavitary combined with CT-guided interstitial brachytherapy for locally advanced uterine cervical cancer. Introduction of the technique and a case presentation  

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We report a new technique of brachytherapy consisting of intracavitary combined with computed tomography (CT)-guided interstitial brachytherapy for locally advanced cervical cancer. A Fletcher-Suit applicator and trocar point needles were used for performing high-dose rate brachytherapy under in-room CT guidance. First, a tandem and ovoids were implanted into the patient's vagina and uterus by conventional brachytherapy method. Based on clinical examination and MRI/CT imaging, operating radiation oncologists decided the positions of insertion in the tumor and the depth of the needles from the upper surface of the ovoid. Insertion of the needle applicator was performed from the vaginal vault inside the ovoid within the tumor under CT guidance. In treatment planning, dwell positions and time adaptations within the tandem and ovoids were performed first for optimization based on the Manchester system, and then stepwise addition of dwell positions within the needle was continued. Finally, dwell positions and dwell weights were manually modified until dose-volume constraints were optimally matched. In our pilot case, the dose of D90 to high-risk clinical target volume was improved from 3.5 Gy to 6.1 Gy by using our hybrid method on the dose-volume histogram. D1cc of the rectum, bladder and sigmoid colon by our hybrid method was 4.8 Gy, 6.4 Gy and 3.5 Gy, respectively. This method consists of advanced image-guided brachytherapy that can be performed safely and accurately. This approach has the potential of increasing target coverage, treated volume, and total dose without increasing the dose to organs at risk. (author)

208

Alterações citopatológicas e fatores de risco para a ocorrência do câncer de colo uterino Alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero Citopathological alterations and risk factors for uterine cervical neoplasm  

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Full Text Available O objetivo do estudo foi verificar alterações citopatológicas e fatores de risco para o câncer de colo uterino em mulheres usuárias do Sistema Único de Saúde de um município de pequeno porte do norte do Paraná, de 2001 a 2006. Trata-se de um estudo observacional transversal descritivo. A coleta de dados foi realizada com os resultados dos exames, prontuários e entrevistas. Foram realizados 6.356 exames e 65(1,02% apresentaram alterações. Dos exames realizados, 4.869 (70,8% foram em mulheres de 25 a 59 anos. 38,5% dos exames apresentaram Neoplasia Intraepitelial Cervical (NIC I, 32,3% NIC II e 18,5% NIC I e Papiloma Vírus Humano (HPV. Foram entrevistadas 25 mulheres, a maioria apresentou algum fator de risco como: tabagismo, doenças sexualmente transmissíveis, uso de anticoncepcional hormonal, número de parceiros, início precoce da atividade sexual. Conclui-se pela necessidade de ações educativas mais efetivas no sentido de reduzir as alterações principalmente entre as mulheres adolescentes.El objetivo del estudio fue verificar alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero en mujeres atendidas por el Sistema Único de la Salud de una ciudad de pequeño porte en la Región Norte de la Provincia del Paraná, Brasil en el período de 2001 al 2006. Se trata de un estudio observacional transversal descriptivo. La colección de los datos fue realizada con los resultados de los exámenes, prontuarios y entrevistas. Fueron realizados 6.356 exámenes y 65(1,02% presentaron alteraciones. De los exámenes hechos 4.869 (70,8% fue compuesto de mujeres con edad entre los 25 a los 59 años. Un total de 38,5% de los exámenes presentaron Neoplasia Intra-epitelial del Cuello Uterino (NIC I, 32,3% NIC II y 18,5% NIC I y Virus de Papiloma Humano (HPV. Fueron entrevistadas 25 mujeres, la mayoría presentó factores de riesgo como: tabaquismo, enfermedades de transmisión sexual, uso de anticonceptivo hormonal, número de parejas sexuales, inicio precoz de la actividad sexual. Concluyese ser necesarias acciones educativas para efectivamente producir la reducción de las alteraciones antes de todo entre mujeres más jóvenes.The aim of the present study was to verify the occurrence of citopathological alterations and risk factors of Uterine Cervical Neoplasm in women attended by SUS - the Public Healthcare System - in a district situated in the North of Paraná State, Brazil from 2001 to 2006. It was a descriptive transversal observational study. The data collection consisted in collection of test results from medical records and interviews. It was achieved 6.356 tests and, 1.02% (65 of the women examined presented alterations. From the tests made 4.869 (70,8% were from women aged between 25 and 59 years. And 38,5% of the tests presented Cervical Intraepithelial Neoplasm (CIN I, 32,3% CIN II, 18,5% CIN I and Human Papiloma Virus (HPV. It was interviewed 25 women from the total sample. Most of them presented a risk factor as: smoking habits, sexually transmitted diseases, use of hormonal contraceptive, number of sexual partners, early sexual intercourse. This study concludes that is required educative and more effective actions in order to reduce the alterations, meanly among teenagers.

Simone Cristina Castanho Sabaini de Melo

2009-12-01

209

Alterações citopatológicas e fatores de risco para a ocorrência do câncer de colo uterino / Citopathological alterations and risk factors for uterine cervical neoplasm / Alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O objetivo do estudo foi verificar alterações citopatológicas e fatores de risco para o câncer de colo uterino em mulheres usuárias do Sistema Único de Saúde de um município de pequeno porte do norte do Paraná, de 2001 a 2006. Trata-se de um estudo observacional transversal descritivo. A coleta de d [...] ados foi realizada com os resultados dos exames, prontuários e entrevistas. Foram realizados 6.356 exames e 65(1,02%) apresentaram alterações. Dos exames realizados, 4.869 (70,8%) foram em mulheres de 25 a 59 anos. 38,5% dos exames apresentaram Neoplasia Intraepitelial Cervical (NIC) I, 32,3% NIC II e 18,5% NIC I e Papiloma Vírus Humano (HPV). Foram entrevistadas 25 mulheres, a maioria apresentou algum fator de risco como: tabagismo, doenças sexualmente transmissíveis, uso de anticoncepcional hormonal, número de parceiros, início precoce da atividade sexual. Conclui-se pela necessidade de ações educativas mais efetivas no sentido de reduzir as alterações principalmente entre as mulheres adolescentes. Abstract in spanish El objetivo del estudio fue verificar alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero en mujeres atendidas por el Sistema Único de la Salud de una ciudad de pequeño porte en la Región Norte de la Provincia del Paraná, Brasil en el período de 2001 al [...] 2006. Se trata de un estudio observacional transversal descriptivo. La colección de los datos fue realizada con los resultados de los exámenes, prontuarios y entrevistas. Fueron realizados 6.356 exámenes y 65(1,02%) presentaron alteraciones. De los exámenes hechos 4.869 (70,8%) fue compuesto de mujeres con edad entre los 25 a los 59 años. Un total de 38,5% de los exámenes presentaron Neoplasia Intra-epitelial del Cuello Uterino (NIC) I, 32,3% NIC II y 18,5% NIC I y Virus de Papiloma Humano (HPV). Fueron entrevistadas 25 mujeres, la mayoría presentó factores de riesgo como: tabaquismo, enfermedades de transmisión sexual, uso de anticonceptivo hormonal, número de parejas sexuales, inicio precoz de la actividad sexual. Concluyese ser necesarias acciones educativas para efectivamente producir la reducción de las alteraciones antes de todo entre mujeres más jóvenes. Abstract in english The aim of the present study was to verify the occurrence of citopathological alterations and risk factors of Uterine Cervical Neoplasm in women attended by SUS - the Public Healthcare System - in a district situated in the North of Paraná State, Brazil from 2001 to 2006. It was a descriptive transv [...] ersal observational study. The data collection consisted in collection of test results from medical records and interviews. It was achieved 6.356 tests and, 1.02% (65) of the women examined presented alterations. From the tests made 4.869 (70,8%) were from women aged between 25 and 59 years. And 38,5% of the tests presented Cervical Intraepithelial Neoplasm (CIN) I, 32,3% CIN II, 18,5% CIN I and Human Papiloma Virus (HPV). It was interviewed 25 women from the total sample. Most of them presented a risk factor as: smoking habits, sexually transmitted diseases, use of hormonal contraceptive, number of sexual partners, early sexual intercourse. This study concludes that is required educative and more effective actions in order to reduce the alterations, meanly among teenagers.

Simone Cristina Castanho Sabaini de, Melo; Letícia, Prates; Maria Dalva de Barros, Carvalho; Sonia Silva, Marcon; Sandra Marisa, Pelloso.

210

Uterine sarcomas.  

Science.gov (United States)

A wide variety of sarcomas occur in the uterus but two subtypes - leiomyosarcoma and endometrial stromal sarcoma - account for a majority of those more routinely encountered. Using the 2003 World Health Organization classification, this review focuses on six uterine sarcomas: endometrial stromal sarcoma, undifferentiated endometrial sarcoma, leiomyosarcoma, rhabomyosarcoma, angiosarcoma and liposarcoma. The epidemiological, clinical, pathological and molecular features are presented along with therapeutic approaches. Familiarity with molecular aspects of these tumors and application of novel technologies in their assessment should be encouraged as they may provide alternate therapies resulting in improved survival for the patient. Clinical information necessary for accurate diagnosis of these lesions is emphasised. A multidisciplinary approach to management of patients with uterine sarcomas is essential for optimal management. PMID:17365823

Moinfar, Farid; Azodi, Masood; Tavassoli, Fattaneh A

2007-02-01

211

Análise de um programa municipal de prevenção do câncer cérvico-uterino Análisis de un programa municipal de prevención del cáncer del cuello uterino Analysis of a municipal program of uterine cervical neoplasm prevention  

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Full Text Available Trata-se de um estudo descritivo-exploratório com objetivo de analisar o programa de prevenção do câncer cérvico uterino no município de Igarapava/SP. No ano de 2006, a rede pública municipal realizou uma cobertura de 14,9% da população feminina na faixa etária de 25 a 59 anos, metade da razão mínima esperada para os municípios, sendo a faixa etária predominante das coletas de 20 a 34 anos (43,2%. Um total de 6,3% não compareceu no serviço de saúde a fim de receber o resultado. Quanto aos resultados das coletas, 51.6% (774 estavam dentro dos limites de normalidade e 47,9% (719 apresentaram alguma alteração, sendo 0,1% compatível com NIC II e III.Se trata de un estudio descriptivo-exploratorio con el objetivo de análisar el programa de prevención del cáncer del cuello uterino en el distrito municipal de Igarapava/SP. En el año de 2006, la red pública municipal realizó una cobertura de 14,9% de la población femenina en la faja de edad de 25 a 59 años, la mitad de la razón mínima esperada para los distritos municipales, siendo la faja de edad predominante de las colecciones de 20 a 34 años (43,2%. Un total de 6,3% no asistió en el servicio de salud para recibir el resultado. En cuanto a los resultados de las colecciones, 51,6% (774 de ellos estaban dentro de los límites de normalidad y 47,9% (719 de ellos presentaron alguna alteración, mientras siendo 0,1% compatible con NIC II e III.This is a descriptive-exploratory study that aimed at analysing the program of uterine cervical neoplasm prevention in the city of Igarapava/SP. In the year of 2006, the municipal public service realized a preventive program with 14.9% of the feminine population from 25 to 59 years old, half of the minimum expected for the cities, whereas the predominant age of those colleted were of 20 to 34 years old (43.2%. A total of 6.3% did not show up at the public health centers in order to get the results. Regarding the results of the collecting, 51.6% (774 were within the limits of normality and 47.9% (719 presented some alteration, where 0.1% were compatible with CIN I and II.

Maurícia Brochado Oliveira Soares

2010-04-01

212

Primary non-Hodgkin's lymphoma of the uterine cervix: A case report  

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Primary uterine cervical non-Hodgkin's lymphomas (NHL) are rare. Limited experience dictates careful pretherapy evaluation and multidisciplinary approach in treatment planning. A 53-year-old woman presented with postmenopausal bleeding and PAP smear IIIb. Cervical biopsy and endocervical curettage biopsy revealed NHL of the uterine cervix. Abdominal hysterectomy with bilateral adnexectomy was followed by pelvic lymphadenectomy due to lymph node metastasis, 21 months after the primary operatio...

Živaljevi? Milica; Vujkov Tamara; Jovanovi? Darjana V.; Mandi? Aljoša; Mihajlovi? Olgica; Prvulovi? Mladen; Stojiljkovi? Bratislav T.

2004-01-01

213

Uterine lipoma.  

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Pure lipoma of the uterus is a rare entity and few cases have been reported. They usually develop in postmenopausal women. Clinical symptoms and physical signs are similar to those found in leiomyomas. The histogenesis of these lesions is still unclear. The diagnosis is easily made at the time of surgery or at autopsy, but before this, they may lead to many problems in the differential diagnosis with another uterine tumors. Recent papers suggest the possibility of a preoperative diagnosis made by computed tomography and magnetic resonance imaging. We report a case of a 67-year-old postmenopausal women presented with pelvic pressure and urinary symptoms. Pathological evaluation revealed pure intramural lipoma of the uterus illustrating characteristic morphological and histological findings with no evidence of sarcomata's component.

Jaudah A. Al-Maghrabi

2004-10-01

214

Ultrastaging of lymph node in uterine cancers  

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Full Text Available Abstract Background Lymph node status is an important prognostic factor and a criterion for adjuvant therapy in uterine cancers. While detection of micrometastases by ultrastaging techniques is correlated to prognosis in several other cancers, this remains a matter of debate for uterine cancers. The objective of this review on sentinel nodes (SN in uterine cancers was to determine the contribution of ultrastaging to detect micrometastases. Methods Review of the English literature on SN procedure in cervical and endometrial cancers and histological techniques including hematoxylin and eosin (H&E staining, serial sectioning, immunohistochemistry (IHC and molecular techniques to detect micrometastases. Results In both cervical and endometrial cancers, H&E and IHC appeared insufficient to detect micrometastases. In cervical cancer, using H&E, serial sectioning and IHC, the rate of macrometastases varied between 7.1% and 36.3% with a mean value of 25.8%. The percentage of women with micrometastases ranged from 0% and 47.4% with a mean value of 28.3%. In endometrial cancer, the rate of macrometastases varied from 0% to 22%. Using H&E, serial sectioning and IHC, the rate of micrometastases varied from 0% to 15% with a mean value of 5.8%. In both cervical and endometrial cancers, data on the contribution of molecular techniques to detect micrometastases are insufficient to clarify their role in SN ultrastaging. Conclusion In uterine cancers, H&E, serial sectioning and IHC appears the best histological combined technique to detect micrometastases. Although accumulating data have proved the relation between the risk of recurrence and the presence of micrometastases, their clinical implications on indications for adjuvant therapy has to be clarified.

Uzan Serge

2010-01-01

215

Uterine metastasis of invasive ductal breast carcinoma diagnosed by cytological examination in an asymptomatic patient: an unusual case report  

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Full Text Available Uterine metastasis of malignant tumors occurs very rarely. Despite abnormal uterine bleeding is the most common symptom of metastatic uterine disease, less than 5% of patients may have not any gynecologic symptoms and diagnosis is made usually following abnormal cervical cytology. Here we present a case of uterine metastasis of invasive ductal breast carcinoma that was diagnosed by cervical cytological examination during breast cancer follow up. Even if there are not any gynecologic symptoms and findings in a patient who has breast cancer history, a detail systematic pelvic examination of these patients must be done yearly.

Ça?da? Türky?lmaz

2007-10-01

216

Immature Uterine Teratoma Associated with Uterine Inversion  

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Teratomas are the most commonly diagnosed germ cell tumors and occur primarily in testes and ovaries. Platinum-based therapy followed by surgical resection of the residual lesion is generally the recommended treatment. In contrast, immature uterine teratomas are rare, with few cases reported in the literature. Moreover, there is no standard treatment for these tumors. Non-puerperal uterine inversion is also rare in women younger than 45 years of age, and neoplastic lesions are responsible for this condition. Here, we report a case of an immature uterine teratoma associated with uterine inversion. The patient underwent surgery followed by adjuvant chemotherapy and continues to be monitored. PMID:25276328

Souza, Karla Teixeira; Negrao, Marcelo Vailati; da Silva Rocha, Lucila Soares; Di Favero, Giovanni; da Costa, Samantha Cabral Severino; Diz, Maria Del Pilar Estevez

2014-01-01

217

Immature uterine teratoma associated with uterine inversion  

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Full Text Available Teratomas are the most commonly diagnosed germ cell tumors and occur primarily in testes and ovaries. Platinum-based therapy followed by surgical resection of the residual lesion is generally the recommended treatment. In contrast, immature uterine teratomas are rare, with few cases reported in the literature. Moreover, there is no standard treatment for these tumors. Non-puerperal uterine inversion is also rare in women younger than 45 years of age, and neoplastic lesions are responsible for this condition. Here, we report a case of an immature uterine teratoma associated with uterine inversion. The patient underwent surgery followed by adjuvant chemotherapy and continues to be monitored.

Karla Teixeira Souza

2014-07-01

218

Uterine torsion in term pregnancy  

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Full Text Available Introduction Uterine torsion has been defined as a rotation of more than 45 degrees of the uterus around its long axis that occurs at the junction between the cervix and the corpus. The extent of the rotation is usually 180 degrees, although cases with torsion from 60 to 720 degrees have been reported. Aetiopathogenesis of this condition is still unclear. Establishing clinical diagnosis of this condition is difficult, but very important for reducing maternal and fetal morbidity and mortality. Clinical symptoms are either absent or nonspecific, and the diagnosis is usually made at laparotomy. Case outlineA 31-year old patient was admitted to the Institute of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, as an emergency, seven days upon the established intrauterine fetal demise in the 40th gestation week. On uterine examination, the cervical length of 1.5 cm and dilatation of 3 cm were determined, as well as a palpable soft tissue formation, not resembling placenta praevia. Ultrasound examination confirmed fetal demise and exclusion of the presence of placenta praevia. The labor was completed by caesarean section. During surgery, uterine torsion of 180 degrees to the right was diagnosed. There was a stillborn male baby, and the cause of death was intrauterine asphyxia. A fibrosing and calcified accessory lobe 9x6x2.5 cm in size was observed on placental examination, which is a possible sign of initial gemellary pregnancy. Conclusion The clinical presentation of uterine torsion is variable and clinical examination and ultrasonographic scanning may be insufficient for diagnosis. The method of choice for establishing the diagnosis is magnetic resonance imaging. Once the diagnosis of uterine torsion in pregnancy is established, emergency laparotomy is indicated. Following caesarean delivery, it is necessary to surgically remove all the anatomical causes of torsion, and rotate the uterus back to its normal position. There are some authors who suggest bilateral plication of the round ligaments as a preventive procedure for repeated torsion in puerperium and following pregnancies. The effectiveness of this method requires further investigation. It is necessary to have in mind the possibility of uterine torsion in all cases of abdominal pain during pregnancy and dystocia.

Spari? Radmila

2007-01-01

219

Uterine Fibroid Embolization  

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Full Text Available ... is for uterine fibroids. Over the past 15 years, we've developed some new procedures that allow ... us. This is a young woman. She's 31 years old. She has very symptomatic uterine fibroids, very ...

220

Uterine Fibroid Embolization  

Medline Plus

Full Text Available Uterine Fibroid Embolization Baptist Health South Florida Miami, FL March 25, 2010 Good afternoon, and welcome to the Baptist ... is going to be an embolization of uterine fibroids. So we're going to show you the ...

 
 
 
 
221

Uterine artery embolization - discharge  

Science.gov (United States)

Uterine fibroid embolization - discharge; UFE - discharge; UAE - discharge ... You had uterine artery embolization (UAE). UAE is a procedure to treat fibroids using radiology instead of surgery. During the procedure, the blood supply of the fibroids ...

222

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... old. She has very symptomatic uterine fibroids, very heavy menstrual periods. Her periods last on the order ... we see in women with uterine fibroids is heavy bleeding. In fact, some of our patients have ...

223

Modification of conservative treatment of heterotopic cervical pregnancy by Foley catheter balloon fixation with cerclage sutures at the level of the external cervical os: a case report  

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Full Text Available Abstract Introduction Conservative treatment of a heterotopic cervical pregnancy was performed with a modification of the fixation of a Foley catheter at the level of the external cervical os, followed by the ligature of the descending cervical branches of the uterine arteries and systemic methotrexate application. Case presentation A 34-year-old Caucasian woman was diagnosed with double gestation after 6 weeks of in vitro fertilization treatment. A gynecological examination and color Doppler ultrasound scan revealed intra-uterine and cervical gestational sacs both containing live fetuses. A Foley catheter balloon was inserted into the cervical canal, inflated and fixed by a cerclage suture at the level of the external cervical os, followed by ligation of the descending cervical branches of the uterine arteries. Systemic methotrexate was applied. Three days after removal of the Foley catheter, an evacuation of the intra-uterine gestational sac was performed. Hemorrhage from the implantation site was controlled immediately and a pregnancy termination was successfully performed. The procedure was uneventful and our patient was discharged with a preserved uterus. Conclusions Conservative treatment of cervical pregnancy using a Foley catheter balloon is more efficacious if the Foley catheter balloon is attached in the correct position with a cerclage suture at the level of the external os, followed by ligation of the descending cervical branches of the uterine arteries, thereby exerting maximal pressure on the bleeding vessels.

Vujisic Sanja

2010-07-01

224

Factors associated with patency of the uterine cervix in bitches with pyometra.  

Science.gov (United States)

This study examined factors involved in the patency of uterine cervices in the bitch with pyometra. The uterine cervices were obtained from the bitches with pyometra at the time of ovariohysterectomy. Cervical patency was measured by inserting the stainless steel rods with different diameter into cervical canals. Collagen concentration and collagenase activity (for type I collagen) in the tissue were determined and the number of neutrophils, which contain the enzymes related to collagen metabolism, and morphological changes in collagenous fibers were studied by histological examination. Levels of mRNA expressions for hormonal factors, estrogen receptor-? (ER-?), progesterone receptor (PR), relaxin (Rlx) and an attractant of neutrophils, interleukin-8 (IL-8), were determined by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). In the statistical analysis, the cervical patency positively correlated with the collagenase activity, and negative correlation was found between the cervical patency and collagen concentration. Histological examination indicated distinct positive correlation between the cervical patency and the number of neutrophils in the cervical stroma and that the collagenous fiber in the uterine cervix became thinner and degraded with increase of the cervical patency. Although there was no relationship between the cervical patency and the level of mRNA for ER-?, PR or Rlx, IL-8 mRNA level has significant positive correlation with the cervical patency and the number of neutrophils in the cervical stroma. These results suggest that the increased number of neutrophils in the uterine cervix, which could be related to the local expression of IL-8, may be involved in collagen degradation and connective tissue remodeling to increase cervical patency in the bitch with pyometra. PMID:22727196

Tamada, Hiromichi; Kawata, Naoko; Kawate, Noritoshi; Inaba, Toshio; Kida, Kayoko; Hatoya, Shingo; Akune, Atsushi; Nakama, Kazuhiro; Kohsaka, Tetsuya; Takahashi, Masahiro; Sawada, Tsutomu

2012-12-01

225

Erosion and erosion-corrosion  

International Nuclear Information System (INIS)

It is very difficult to interpret the technical term of erosion-corrosion' which is sometimes encountered in piping systems of power plants, because of complicated mechanisms and several confusing definitions of erosion-corrosion phenomena. 'FAC (flow accelerated corrosion)' is recently introduced as wall thinning of materials in power plant systems, as a representative of 'erosion-corrosion'. FAC is, however, not necessarily well understood and compared with erosion-corrosion. This paper describes firstly the origin, definition and fundamental understandings of erosion and erosion-corrosion, in order to reconsider and reconfirm the phenomena of erosion, erosion-corrosion and FAC. Next, typical mapping of erosion, corrosion, erosion-corrosion and FAC are introduced in flow velocity and environmental corrosiveness axes. The concept of damage rate in erosion-corrosion is finally discussed, connecting dissolution rate, mass transfer of metal ions in a metal oxide film and film growth. (author)

226

Cervical Dysplasia  

Science.gov (United States)

What is cervical dysplasia? Cervical dysplasia is abnormal cell growth on the surface lining of the cervix. With proper follow-up and treatment, ... cancer. Who is most likely to have cervical dysplasia? Although cervical dysplasia is most common in women ...

227

Modern review of pathogenesis of urgent uterine bleedings in obstetrical and gynecological practice  

Directory of Open Access Journals (Sweden)

Full Text Available The article presents modern data concerning mechanisms of uterine bleedings in undeveloped pregnancy, hystero-myoma, and cervical carcinoma. Hemostasis system malfunctions appeared in case of dead foetus in uterus have been considered in the work. They are manifested by consumption coagulopathy and haemorrhagic complications. Uterine bleedings in case of hysteromyoma are caused by dilation of arterial vessels and deprivation of their contractile function and malfunction myometrium contraction. Complications that occur in oncological uterine bleedings arrest have been described. They are caused by individual uterine blood supply and developed network of collateral anastomoses between branches of internal iliac arteries

Rogozhina I.E.

2011-03-01

228

PECULIARITIES OF CHANGES ?F IMMUNOREGULATORY SYSTEM OF WOMEN WITH BACKGROUNG PATHOLOGY OF UTERINE CERVIX (NA)  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A comparative research of cytokines IL-1b, IL-4, IL-6, IL-8, INF-/, TNF-a and its concentration in cellular material suspension on surface of pseudo erosion of uterine cervix was carried out. It was clarified that inefficient activation of local protective factors of immune system plays the main role in clinical behavior of pseudo erosion of uterine cervix. Imbalance of cytokines output to pro-inflammatory factors was observed.

Zakharova, N. B.; Khripunova, G. I.; Gribova, S. N.

2009-01-01

229

PECULIARITIES OF CHANGES ?F IMMUNOREGULATORY SYSTEM OF WOMEN WITH BACKGROUNG PATHOLOGY OF UTERINE CERVIX (NA  

Directory of Open Access Journals (Sweden)

Full Text Available A comparative research of cytokines IL-1b, IL-4, IL-6, IL-8, INF-/, TNF-a and its concentration in cellular material suspension on surface of pseudo erosion of uterine cervix was carried out. It was clarified that inefficient activation of local protective factors of immune system plays the main role in clinical behavior of pseudo erosion of uterine cervix. Imbalance of cytokines output to pro-inflammatory factors was observed.

N.B. Zakharova

2009-03-01

230

Cyto-histopathological correlations in uterine cervix pathology  

Directory of Open Access Journals (Sweden)

Full Text Available linical significant cervical lesions are often correlated with epithelial cell abnormalities on cervical smears. The histologic lesions which are found in uterine cervix can not be always established only with conventional cytology. Thus, it is very important that any cytologic abnormality be subsequently correlated with biopsy for certification of a cervical lesion. The results of cervical smears and tissue diagnoses over a five year period were reviewed, being examined the correlations between the cervico-vaginal smears and the surgical specimens. All cervical smears with their subsequent biopsies and histerectomies, between 2003-2008 were retrospectively evaluated. The patients ages were between 18 and 70 years old. The cervical cytology records were verifyied and the cytodiagnosis were compared with the correspondent histopathological diagnosis. From the 5700 cervico-vaginal smears, diagnosticated in the mentioned period of time, 3835 were negative for intraepithelial lesion or malignancy. The others of 1865 presented squamous and glandular lesions, and cervical carcinoma. One case, of a 20 years old girl, had a cytodiagnostic with suspicion of sarcoma, which was confirmed on biopsy and subsequent histerectomy as a cervical embrional rhabdomyosarcoma. The exfoliative cytologic cervico-vaginal test is very important in precocious diagnosis of intraepithelial cervical lesions, especially when it its correlated with histopathologic examination. The immunohistochemical and molecular testing of high-risk HPV will contribute to a better management of cervical precancerous lesions.

Ovidiu Toma

2009-06-01

231

Uterine artery embolization to treat uterine fibroids  

Energy Technology Data Exchange (ETDEWEB)

The first reported application of uterine artery embolization, in 1979, was to treat life-threatening hemorrhage after a failed hysterectomy. Since then, uterine artery embolization has been used very successfully to control acute or delayed post-partum hemorrhage, post-surgical hemorrhage and hemorrhage from ectopic pregnancy, to treat uterine arteriovenous malformations and as prophylaxis before high-risk surgery, such as cesarean delivery in women with placenta previa. In contrast to these proven but underutilized applications, uterine embolization for fibroids has, in a short time, achieved significant notice in the lay press and is being widely offered. Ravina and colleagues, first reported uterine fibroid shrinkage after embolization for the treatment of acute bleeding. Since then, his group has performed over 100 procedures with up to a 6-year follow-up. The cumulative clinical success rate for the treatment of abnormal uterine bleeding due to fibroids is reported to be approximately 85% and for treatment of pain or pressure symptoms, about 75%. Six-month follow-up sonography reveals an average reduction of fibroid size of approximately 40%. However, to date, no studies have compared patients who undergo embolization with a nontreatment cohort or with surgical intervention. (author)

Machan, L.; Martin, M. [Univ. of British Columbia Hospital, Dept. of Radiology, Vancouver, BC (Canada)

2001-06-01

232

Uterine artery embolization to treat uterine fibroids  

International Nuclear Information System (INIS)

The first reported application of uterine artery embolization, in 1979, was to treat life-threatening hemorrhage after a failed hysterectomy. Since then, uterine artery embolization has been used very successfully to control acute or delayed post-partum hemorrhage, post-surgical hemorrhage and hemorrhage from ectopic pregnancy, to treat uterine arteriovenous malformations and as prophylaxis before high-risk surgery, such as cesarean delivery in women with placenta previa. In contrast to these proven but underutilized applications, uterine embolization for fibroids has, in a short time, achieved significant notice in the lay press and is being widely offered. Ravina and colleagues, first reported uterine fibroid shrinkage after embolization for the treatment of acute bleeding. Since then, his group has performed over 100 procedures with up to a 6-year follow-up. The cumulative clinical success rate for the treatment of abnormal uterine bleeding due to fibroids is reported to be approximately 85% and for treatment of pain or pressure symptoms, about 75%. Six-month follow-up sonography reveals an average reduction of fibroid size of approximately 40%. However, to date, no studies have compared patients who undergo embolization with a nontreatment cohort or with surgical intervention. (author)

233

Soil Erosion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

One element of the CIVCAL project Web-based resources containing images, tables, texts and associated data of the Soil Erosion. The word "erosion" is derived from the Latin "erosio", meaning to "to gnaw away". In general terms soil erosion implies the physical removal of topsoil by various agents, including rain, water flowing over and through the soil profile, wind, ice or gravitational pull. This part of the CIVCAL project introduces the processes and control of soil erosion, includi...

Kumaraswamy, Mohan

2002-01-01

234

Cervical Myomas  

Science.gov (United States)

... Health Issues > Noncancerous Gynecologic Abnormalities 4 Cervical Myomas Cervical myomas are smooth, benign tumors in the cervix. A myoma may bleed, become infected, interfere with urinating, or cause pain during sexual intercourse. Doctors can see or feel ...

235

Cervical Cancer  

Centers for Disease Control (CDC) Podcasts

Did you know that cervical cancer rates differ by race/ethnicity and region? Or that cervical cancer can usually be prevented if precancerous cervical lesions are found by a Pap test and treated? Find out how getting regular Pap tests can save a woman's life.  Created: 3/6/2007 by National Breast and Cervical Cancer Early Detection Program.   Date Released: 4/25/2007.

2007-03-06

236

Postpartum suppression of ovarian activity with a Deslorelin implant enhanced uterine involution in lactating dairy cows.  

Science.gov (United States)

Holstein cows received, subcutaneously a non-degradable implant containing 5mg of the GnRH agonist Deslorelin (DESL) or no implant (CON) at 2+/-1 days postpartum (dpp). All cows were injected with PGF(2alpha) at 9 dpp. Previous pregnant (PPH) and non-pregnant uterine horns (PNPH) were determined by palpation per rectum. In Experiment 1, cows [DESL implant (n=10) and CON (n=9)] were examined by ultrasonography to record ovarian structures (23, 30 and 37 dpp) and uterine horn and cervical diameters (16, 23, 30 and 37 dpp). Uterine tone was scored before ultrasonography. Vaginoscopy was conducted just after ultrasonography examination to assess cervical discharge and color of the external cervical os. Blood samples were collected on a weekly basis for hormonal analyses. In Experiment 2, cows [DESL implant (n=77) and CON (n=70)] were palpated per rectum and vaginoscopy at 30 dpp for scoring of uterine tone, uterine horns, cervical diameter, and discharge. Blood samples were collected only at 9 dpp. In Experiment 1, DESL-implant-treated cows had more Class 1 follicles (Puterine tone (P=0.07). The DESL-implant cows had a greater frequency of clear cervical discharge (P=0.09) and pink cervical os (P=0.06). In Experiment 2, plasma concentrations of PGFM were less at 9 dpp in DESL-implant treatment (Puterine tone (Pscore did not differ between treatments. Treatment with non-degradable Deslorelin (5mg) implant during postpartum: (1) suppressed ovarian follicular development, (2) enhanced physical involution of the uterus and cervix, (3) increased tone of the uterine wall, (4) decreased frequency of purulent cervical discharges, and (5) reduced inflammatory processes of the reproductive tract. PMID:18243603

Silvestre, F T; Bartolome, J A; Kamimura, S; Arteche, A C; Pancarci, S M; Trigg, T; Thatcher, W W

2009-01-01

237

Total and acute uterine inversion after delivery: a case report  

Science.gov (United States)

Introduction Uterine inversion is a rare obstetric emergency that can lead to hypovolemic shock or even maternal death. There are many management strategies, but they are poorly described and dispersed in the medical literature. The purpose of this article is to describe a case of complete acute uterine inversion and a review of the literature. Case presentation The authors describe a case of complete uterine inversion after a normal delivery with fundal placenta and without cord traction, in a 33-year-old Caucasian woman. After the diagnosis was made and after several attempts of manual correction of the inversion, the patient was taken immediately to the operating room and a laparotomy was performed. With opposing pressures in the cervical ring through the abdominal cavity and on the uterus fundus through her vagina, the inversion was resolved. An incision on the cervical ring was unnecessary. Due to incomplete detachment of the placenta the bleeding was mild. She recovered without complications and the histological examination of placenta was unremarkable. In this case, the only risk factor for uterine inversion was the fundal implantation of the placenta. Conclusions The low incidence of uterine inversion leads to sparse experience in resolving this obstetrical emergency. The best prognosis occurs in situations where the diagnosis and maneuvers for uterine reversal are made at an early stage. The authors concluded that opposing pressures in the cervical ring through the abdominal cavity and on the uterus fundus through the vagina can resolve the inversion without the need of other surgical techniques. It is essential to keep in mind this diagnosis, and be updated about the strategies required to solve this complication. PMID:25326075

2014-01-01

238

Uterine cervical carcinoma: a comparison of two- and three-dimensional T2-weighted turbo spin-echo MR imaging at 3.0 T for image quality and local-regional staging  

International Nuclear Information System (INIS)

To compare three-dimensional (3D) T2-weighted turbo spin-echo (TSE) with multiplanar two-dimensional (2D) T2-weighted TSE for the evaluation of invasive cervical carcinoma. Seventy-five patients with cervical carcinoma underwent MRI of the pelvis at 3.0 T, using both 5-mm-thick multiplanar 2D (total acquisition time = 12 min 25 s) and 1-mm-thick coronal 3D T2-weighted TSE sequences (7 min 20 s). Quantitative analysis of signal-to-noise ratio (SNR) and qualitative analysis of image quality were performed. Local-regional staging was performed in 45 patients who underwent radical hysterectomy. The estimated SNR of cervical carcinoma and the relative tumour contrast were significantly higher on 3D imaging (P < 0.0001). Tumour conspicuity was better with the 3D sequence, but the sharpness of tumour margin was better with the 2D sequence. No significant difference in overall image quality was noted between the two sequences (P = 0.38). There were no significant differences in terms of the diagnostic accuracy, sensitivity, and specificity of parametrial invasion, vaginal invasion, and lymph node metastases. Multiplanar reconstruction 3D T2-weighted imaging is largely equivalent to 2D T2-weighted imaging for overall image quality and staging accuracy of cervical carcinoma with a shorter MR data acquisition, but has limitations with regard to the sharpness of the tumour margin. circle 3D T2-weighted MR sequence is equivalent to 2D for cervical carcinoma staging. (orig.)

239

Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia  

Directory of Open Access Journals (Sweden)

Full Text Available Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron entrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %, 36 citología anormal (2 % y 638 cambios celulares reactivos asociados a inflamación (37 %. Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país.Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire to collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %, 36 abnormal cytology (2 % and 638 reactive cellular changes associated with inflammation (37 %. The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

Yaliana Tafurt-Cardona

2012-02-01

240

Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia / The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron e [...] ntrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %), 36 citología anormal (2 %) y 638 cambios celulares reactivos asociados a inflamación (37 %). Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país. Abstract in english Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire t [...] o collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %), 36 abnormal cytology (2 %) and 638 reactive cellular changes associated with inflammation (37 %). The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

Yaliana, Tafurt-Cardona; Claudia P, Acosta-Astaiza; Carlos H, Sierra-Torres.

2012-02-01

 
 
 
 
241

Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia / The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: Spanish Abstract in spanish Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron e [...] ntrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %), 36 citología anormal (2 %) y 638 cambios celulares reactivos asociados a inflamación (37 %). Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país. Abstract in english Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire t [...] o collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %), 36 abnormal cytology (2 %) and 638 reactive cellular changes associated with inflammation (37 %). The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

Yaliana, Tafurt-Cardona; Claudia P., Acosta-Astaiza; Carlos H., Sierra-Torres.

2012-02-01

242

Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia / The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: Spanish Abstract in spanish Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron e [...] ntrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %), 36 citología anormal (2 %) y 638 cambios celulares reactivos asociados a inflamación (37 %). Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país. Abstract in english Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire t [...] o collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %), 36 abnormal cytology (2 %) and 638 reactive cellular changes associated with inflammation (37 %). The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

Yaliana, Tafurt-Cardona; Claudia P., Acosta-Astaiza; Carlos H., Sierra-Torres.

243

Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia / The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron e [...] ntrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %), 36 citología anormal (2 %) y 638 cambios celulares reactivos asociados a inflamación (37 %). Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país. Abstract in english Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire t [...] o collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %), 36 abnormal cytology (2 %) and 638 reactive cellular changes associated with inflammation (37 %). The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

Yaliana, Tafurt-Cardona; Claudia P, Acosta-Astaiza; Carlos H, Sierra-Torres.

244

The uterine carcinosarcoma - a case report.  

Science.gov (United States)

The carcinosarcoma is a malignant mixed müllerian tumor with a highly malignant, biphasic tumor consisting of both epithelial and mesenchymal components. The presented case refers to a patient in climax with a vaginal bleeding. The Doppler echography highlights a polypoid mass, which prolapses in the cervical channel. The histopathological and immunohistochemical analysis of the surgically resected piece allowed the carcinosarcoma diagnosis. The uterine carcinosarcoma's incidence is rare, that is why this case is interesting taking in consideration the biphasic pattern of the tumor. PMID:18060197

Niculescu, Mihaela; Simionescu, Cristiana; Novac, Liliana; Mogoant?, L; St?nescu, R M

2007-01-01

245

Abnormal Uterine Bleeding  

Science.gov (United States)

... uterine lining. It's done by putting a thin plastic tube (called a catheter) into your uterus. A tiny piece of the uterine lining is taken out and sent to a lab for testing. The test will show if you have cancer or a change in the cells. A biopsy ...

246

Intra-uterine insemination with prepared sperm vs. unprepared first split ejaculates. A randomized study.  

Science.gov (United States)

In this randomized prospective study, we determined the conception rate following intra-uterine insemination with washed and prepared sperm, or with the first portion of a split ejaculate, in couples with longstanding male (n = 27, 70 treatment cycles) or cervical infertility (n = 14, 29 treatment cycles). Folliculogenesis and ovulation were induced by human menopausal gonadotropin and human chorionic gonadotropin. Significantly more couples conceived in the male infertility group following intra-uterine insemination with washed sperm, than after intra-uterine insemination with split ejaculate (9 vs. 2; P less than 0.05), while no difference in pregnancy rate (2 vs. 2) was found by the two intra-uterine insemination methods in the cervical infertility group. PMID:1503250

Goldenberg, M; Rabinovici, J; Bider, D; Lunenfeld, B; Blankstein, J; Weissenberg, R

1992-01-01

247

Radiotherapy in the treatment of a locally advanced cervical cancer: experience of the Casablanca Radiotherapy-Oncology centre; Radiotherapie dans le traitement du cancer du col uterin localement evolue: experience du centre de radiotherapie-oncologie de Casablanca  

Energy Technology Data Exchange (ETDEWEB)

The authors report the assessment of the local control and relapse rates in a set of 70 patients who had been treated in 2004 and 2005 by radiotherapy associated or not with chemotherapy for a cervical cancer of stage IIbd, III or IVa according to the FIGO classification. The obtained results correspond to that published in literature. The authors expect that the improvement of radiotherapy techniques could improve these results. Short communication

Bouchbika, Z.; Benchakroun, N.; Sellal, N.; Jouhadi, H.; Tawfiq, N.; Sahraoui, S.; Benider, A. [Service radiotherapie-oncologie, CHU Ibn-Rochd, Casablanca (Morocco)

2011-10-15

248

Results of a retrospective study of chemo-radiotherapy for locally advanced cervical cancers; Resultats d'une etude retrospective de chimioradiotherapie dans les cancers du col uterin localement evolues  

Energy Technology Data Exchange (ETDEWEB)

The authors report a retrospective study performed on a set of 285 patients treated for locally advanced cervical cancers between 2003 and 2005. They aimed at analyzing the epidemiological, therapeutic and evolution profiles of this category of patients where cancer is discovered as it has already advanced. It appears that chemo-radiotherapy results in a longer survival, an increased local control, and a reduced metastatic dissemination, without increasing late toxicity. Short communication

Ayad, M.; Mesli, S.; Rabahi, K.; Boualga, K. [Centre anticancer, Blida (Algeria)

2011-10-15

249

Usefulness of {sup 18}FDG PET in the management of cervical cancer; Apport de la TEP au {sup 18}FDG dans la prise en charge du cancer du col uterin  

Energy Technology Data Exchange (ETDEWEB)

Cervical carcinoma is the second most common gynaecological cancer worldwide. Despite substantial advances in screening the pre-invasive forms, the management of women suffering from invasive cervical carcinomas remains problematic. In pre-treatment staging, the evaluation of the loco-regional and distant extent of the disease, according to the international federation of gynecology and obstetrics, has shown to be sub-optimal. After treatment, the routine surveillance protocol, based on a physical examination at the control visits and clinically oriented conventional imaging procedures, most often fails to accurately detect a recurrent disease. Its sensitivity is particularly low for asymptomatic women. On the other hand, the clinical value of positron emission tomography using {sup 18}F-fluorodeoxyglucose in the field of oncology is nowadays firmly established. In many tumour types, including the gynaecological cancers such as breast cancer and ovarian cancer, the metabolic imaging has proved to play a determinant role in both the pre-treatment and post-treatment evaluation. In the present review-article, we analyse in the light of the literature data and our experience, the potential contribution of positron emission tomography using {sup 18}F-fluorodeoxyglucose in the management of cervical cancer. (authors)

Belhocine, T.; Rigo, P. [Centre Hospitalier et Universitaire de Liege (Belgium)

2002-09-01

250

Importancia de los estudios de inmunohistoquímica en el diagnóstico y la evaluación pronóstica de la neoplasia intraepitelial y el cáncer cervical: Revisión / Importance of immunohistochemical studies in the diagnosis and the prognostic evaluation of cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix: Review  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Se evaluó la expresión de proteínas dependientes de genes en el epitelio cervical, en la neoplasia intraepitelial cervical (NIC) y en el carcinoma del cuello uterino (CC) a través de diversos estudios de inmunohistoquímica (IHQ). Se examinó la detección de ciertas proteínas como p53, bcl2, C-Myc, Ki [...] 67, Ciclinas, P16 INK4a, p21, p27, b-catenina, Wnt y MCM, en relación con la evolución de la neoplasia intraepitelial, el carcinoma cervical y la infección con el virus del papiloma humano (VPH). Se señaló como la actividad transcripcional de diversos genes provoca alteraciones de la heterocigosis y pérdida de regiones cromosómicas que influyen en la sobrexpresión de proteínas o en la pérdida parcial de la expresión de algunas glicoproteínas en la superficie celular por la activación de genes del VPH. Abstract in english Immunohistochemical studies in cervical intraepithelial neoplasia and cervical carcinoma are evaluated in this review. A variety of proteíns like p53, bcl2, C-Myc, Ki 67, Cyclines, P16 INK4a, p21, p27, b-catenin, Wnt and MCM, have been related to the development of cervical neoplasia and human papil [...] loma virus infection. It is described how transcriptional factors of genes induce loss of heterozygosity, numerical chromosome abnormality and inactivation of gene products or the partial loss of some membrane glycoproteins induced by oncogenic human papillomaviruses (HPV).

Jorge, García-Tamayo; Julia, Molina; Eduardo, Blasco-Olaetxea.

251

Importancia de los estudios de inmunohistoquímica en el diagnóstico y la evaluación pronóstica de la neoplasia intraepitelial y el cáncer cervical: Revisión / Importance of immunohistochemical studies in the diagnosis and the prognostic evaluation of cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix: Review  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Se evaluó la expresión de proteínas dependientes de genes en el epitelio cervical, en la neoplasia intraepitelial cervical (NIC) y en el carcinoma del cuello uterino (CC) a través de diversos estudios de inmunohistoquímica (IHQ). Se examinó la detección de ciertas proteínas como p53, bcl2, C-Myc, Ki [...] 67, Ciclinas, P16 INK4a, p21, p27, b-catenina, Wnt y MCM, en relación con la evolución de la neoplasia intraepitelial, el carcinoma cervical y la infección con el virus del papiloma humano (VPH). Se señaló como la actividad transcripcional de diversos genes provoca alteraciones de la heterocigosis y pérdida de regiones cromosómicas que influyen en la sobrexpresión de proteínas o en la pérdida parcial de la expresión de algunas glicoproteínas en la superficie celular por la activación de genes del VPH. Abstract in english Immunohistochemical studies in cervical intraepithelial neoplasia and cervical carcinoma are evaluated in this review. A variety of proteíns like p53, bcl2, C-Myc, Ki 67, Cyclines, P16 INK4a, p21, p27, b-catenin, Wnt and MCM, have been related to the development of cervical neoplasia and human papil [...] loma virus infection. It is described how transcriptional factors of genes induce loss of heterozygosity, numerical chromosome abnormality and inactivation of gene products or the partial loss of some membrane glycoproteins induced by oncogenic human papillomaviruses (HPV).

Jorge, García-Tamayo; Julia, Molina; Eduardo, Blasco-Olaetxea.

2009-06-01

252

Avaliação da medida do comprimento do colo e da ausência do eco glandular endocervical para predição do parto pré-termo Evaluation of risk for preterm delivery by measurement of uterine cervix and cervical gland area  

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Full Text Available OBJETIVO: verificar a prevalência do sinal eco glandular endocervical (EGE e o comprimento cervical menor ou igual a 20 mm em gestantes entre a 21ª e a 24ª semana e comparar estes sinais ecográficos como fatores indicadores de parto pré-termo espontâneo. MÉTODOS: estudo prospectivo transversal no qual foram incluídas 361 gestantes da população geral, para realização de exame ultra-sonografico em idade gestacional entre a 21ª a 24ª semana. Os critérios de exclusão do estudo foram malformações müllerianas, gestações múltiplas, malformações fetais, óbito fetal, alterações da quantidade de líquido amniótico, placenta com inserção segmentar, antecedentes de cirurgia no colo uterino (conização, amputação, cerclagem e procedimentos cirúrgicos durante a gestação. Após a realização do exame ultra-sonográfico obstétrico morfológico efetuado por via abdominal, seguiu-se o exame ecográfico por via vaginal para observação de uma faixa hipoecóica ou hiperecóica adjacente ao canal endocervical correpondente às glândulas do epitélio endocervical (EGE e mensuração do comprimento cervical. As variáveis qualitativas são representadas por freqüência absoluta e relativa, ao passo que as variáveis quantitativas, por média, desvio-padrão, mediana e valores mínimo e máximo. A associação entre as variáveis qualitativas foi avaliada pelo teste c² ou teste exato de Fisher. Para cada variável estudada, foi calculado o risco relativo seguido do intervalo com 95% de confiança. A técnica de análise de regressão logística univariada foi utilizada para verificar, entre as variáveis estudadas, quais foram indicativas de parto pré-termo espontâneo. O nível de significância adotado foi de 95% (alfa = 5% e descritivos (p iguais ou inferiores a 0,05 foram considerados significantes. RESULTADOS: a incidência do parto pré-termo espontâneo foi de 5,0%. O comprimento do colo uterino revelou-se igual ou inferior a 20 mm em 3,3% da população estudada e em 27,8% das pacientes que apresentaram parto pré-termo espontâneo. A ausência do EGE foi detectada em 2,8% das pacientes estudadas e em 44,4% das pacientes que evoluíram para parto pré-termo espontâneo. A associação entre ausência do EGE e presença do colo curto revelou-se estatisticamente significante (pPURPOSE: to verify the prevalence of two sonographic findings, the cervical gland area (CGA feature and the cervical length of less than 20 mm, and to compare these with the risk for premature delivery in pregnant women between 21 and 24 weeks' gestation. METHOD: this was a prospective, cross-sectional study in which 361 women were consecutively examined by transvaginal ultrasonography. Müllerian or other malformations, multiple gestations, fetal death, olygo- or polyhydramnios, marginal placenta previa, and conization, cerclage, amputation or other surgical procedures in the cervix, prior to or during pregnancy, were exclusion criteria. After the abdominal ultrasonographic morphological examination, we used transvaginal ultrasonography to measure the cervical length and to observe the presence of hyper- or hypoechoic area next to the endocervical canal, a feature characteristic of endocervical epithelium glands which is called CGA (cervical gland area. Qualitative variables are expressed as absolute and relative frequency. Quantitative variables are expressed as mean, median, standard deviation, minimum, and maximum values. Association between qualitative variables was detected by the c² test or by the Fisher exact test. For each variable, the relative risk and the 95% confidence interval (CI were calculated. Logistic regression analysis was used to calculate the predictive values for premature delivery. Significance level was 95% (alpha = 5%, with descriptive (p values equal or lower than 0.05 considered significant. RESULTS: spontaneous preterm delivery occurred in 5.0% of the patients. Cervical length was up to 20 mm in 3.3% of all studied patients and in 27.8% of those who delivered spontaneously

Claudio Rodrigues Pires

2004-04-01

253

Avaliação da medida do comprimento do colo e da ausência do eco glandular endocervical para predição do parto pré-termo / Evaluation of risk for preterm delivery by measurement of uterine cervix and cervical gland area  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: verificar a prevalência do sinal eco glandular endocervical (EGE) e o comprimento cervical menor ou igual a 20 mm em gestantes entre a 21ª e a 24ª semana e comparar estes sinais ecográficos como fatores indicadores de parto pré-termo espontâneo. MÉTODOS: estudo prospectivo transversal no q [...] ual foram incluídas 361 gestantes da população geral, para realização de exame ultra-sonografico em idade gestacional entre a 21ª a 24ª semana. Os critérios de exclusão do estudo foram malformações müllerianas, gestações múltiplas, malformações fetais, óbito fetal, alterações da quantidade de líquido amniótico, placenta com inserção segmentar, antecedentes de cirurgia no colo uterino (conização, amputação, cerclagem) e procedimentos cirúrgicos durante a gestação. Após a realização do exame ultra-sonográfico obstétrico morfológico efetuado por via abdominal, seguiu-se o exame ecográfico por via vaginal para observação de uma faixa hipoecóica ou hiperecóica adjacente ao canal endocervical correpondente às glândulas do epitélio endocervical (EGE) e mensuração do comprimento cervical. As variáveis qualitativas são representadas por freqüência absoluta e relativa, ao passo que as variáveis quantitativas, por média, desvio-padrão, mediana e valores mínimo e máximo. A associação entre as variáveis qualitativas foi avaliada pelo teste c² ou teste exato de Fisher. Para cada variável estudada, foi calculado o risco relativo seguido do intervalo com 95% de confiança. A técnica de análise de regressão logística univariada foi utilizada para verificar, entre as variáveis estudadas, quais foram indicativas de parto pré-termo espontâneo. O nível de significância adotado foi de 95% (alfa = 5%) e descritivos (p) iguais ou inferiores a 0,05 foram considerados significantes. RESULTADOS: a incidência do parto pré-termo espontâneo foi de 5,0%. O comprimento do colo uterino revelou-se igual ou inferior a 20 mm em 3,3% da população estudada e em 27,8% das pacientes que apresentaram parto pré-termo espontâneo. A ausência do EGE foi detectada em 2,8% das pacientes estudadas e em 44,4% das pacientes que evoluíram para parto pré-termo espontâneo. A associação entre ausência do EGE e presença do colo curto revelou-se estatisticamente significante (p Abstract in english PURPOSE: to verify the prevalence of two sonographic findings, the cervical gland area (CGA) feature and the cervical length of less than 20 mm, and to compare these with the risk for premature delivery in pregnant women between 21 and 24 weeks' gestation. METHOD: this was a prospective, cross-secti [...] onal study in which 361 women were consecutively examined by transvaginal ultrasonography. Müllerian or other malformations, multiple gestations, fetal death, olygo- or polyhydramnios, marginal placenta previa, and conization, cerclage, amputation or other surgical procedures in the cervix, prior to or during pregnancy, were exclusion criteria. After the abdominal ultrasonographic morphological examination, we used transvaginal ultrasonography to measure the cervical length and to observe the presence of hyper- or hypoechoic area next to the endocervical canal, a feature characteristic of endocervical epithelium glands which is called CGA (cervical gland area). Qualitative variables are expressed as absolute and relative frequency. Quantitative variables are expressed as mean, median, standard deviation, minimum, and maximum values. Association between qualitative variables was detected by the c² test or by the Fisher exact test. For each variable, the relative risk and the 95% confidence interval (CI) were calculated. Logistic regression analysis was used to calculate the predictive values for premature delivery. Significance level was 95% (alpha = 5%), with descriptive (p) values equal or lower than 0.05 considered significant. RESULTS: spontaneous preterm delivery occurred in 5.0% of the patients. Cervical

Claudio Rodrigues, Pires; Antonio Fernandes, Moron; Rosiane, Mattar; Luiz, Kulay Júnior.

2004-04-01

254

Uterine Fibroid Embolization  

Directory of Open Access Journals (Sweden)

Full Text Available Uterine fibroids are commonly asymptomatic. They often cause pelvic pain, abnormal and increased vaginal bleeding, etc. Traditional treatment of symptomatic uterine fibroids was trans-abdominal hysterectomy. Nowadays, uterine artery embolization (UAE, also called uterine fibroid embolization, is considered as a safe and highly-effective nonsurgical treatment for women with symptomatic uterine fibroid tumors. Advantages of UAE over conventional hormonal suppression and surgical procedures include avoidance of the side effects of drug therapy and surgery-related physical and psychological trauma. These patients commonly resume their normal activities within a week after the procedure; weeks earlier than that for trans-abdominal hysterectomy. Over the past 30 years, interventional radiologists have done UAE for treatment of emergency uterine bleeding. Since 1995, interventional radiologists have turned their attention to treatment of uterine fibroids with a similar procedure. The first fibroid embolization in Iran was done approximately three years ago. So far, more than 100 cases have been treated by this method and it is going to be quickly accepted as a safe alternate for surgery.

"R. Malek

2003-06-01

255

Uterine fibroids: current perspectives.  

Science.gov (United States)

Uterine fibroids are a major cause of morbidity in women of a reproductive age (and sometimes even after menopause). There are several factors that are attributed to underlie the development and incidence of these common tumors, but this further corroborates their relatively unknown etiology. The most likely presentation of fibroids is by their effect on the woman's menstrual cycle or pelvic pressure symptoms. Leiomyosarcoma is a very rare entity that should be suspected in postmenopausal women with fibroid growth (and no concurrent hormone replacement therapy). The gold standard diagnostic modality for uterine fibroids appears to be gray-scale ultrasonography, with magnetic resonance imaging being a close second option in complex clinical circumstances. The management of uterine fibroids can be approached medically, surgically, and even by minimal access techniques. The recent introduction of selective progesterone receptor modulators (SPRMs) and aromatase inhibitors has added more armamentarium to the medical options of treatment. Uterine artery embolization (UAE) has now been well-recognized as a uterine-sparing (fertility-preserving) method of treating fibroids. More recently, the introduction of ultrasound waves (MRgFUS) or radiofrequency (VizAblate™ and Acessa™) for uterine fibroid ablation has added to the options of minimal access treatment. More definite surgery in the form of myomectomy or hysterectomy can be performed via the minimal access or open route methods. Our article seeks to review the already established information on uterine fibroids with added emphasis on contemporary knowledge. PMID:24511243

Khan, Aamir T; Shehmar, Manjeet; Gupta, Janesh K

2014-01-01

256

Prevalência do exame preventivo de câncer do colo do útero em Rio Branco, Acre, Brasil, e fatores associados à não-realização do exame Prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and factors associated with non-participation in screening  

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Full Text Available O objetivo do estudo foi determinar a prevalência autorreferida do exame preventivo de câncer do colo uterino em Rio Branco, Acre, Brasil, e avaliar fatores associados com a não realização do exame. Trata-se de estudo transversal de base populacional, composto por 772 mulheres de 18 a 69 anos residentes em Rio Branco, no período 2007 a 2008. Os dados foram analisados no programa Stata 10.0 e estimadas razões de prevalências a partir da regressão multivariada de Poisson. O percentual de mulheres na população alvo que relatou pelo menos um exame nos últimos três anos foi de 85,3%, com acentuada utilização do Sistema Único de Saúde (72,8%. Foram encontradas razões de prevalência estatisticamente significativas quanto à ausência do exame em mulheres de 18 a 24 anos, de 60 a 69 anos, solteiras, com menor renda e baixa escolaridade. As magnitudes encontradas nas razões de prevalência foram consistentes com achados de outros estudos, apontando maior necessidade de intervenção no grupo de mulheres mais vulneráveis à incidência e mortalidade por câncer do colo do útero.The objective of the study was to determine the self-reported prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and to analyze factors associated with non-participation in screening. A population-based cross-sectional study with a sample of 772 women 18 to 69 years of age and living in Rio Branco was conducted in 2007 and 2008. Data were analyzed with Stata 10.0, and prevalence rates were estimated with Poisson multivariate regression (95%CI. 85.3% of women reported at least one cervical cancer screening test in the previous three years. The majority of women (72.8% were screened in the Brazilian Unified National Health System. After adjusting for selected variables, statistically significant prevalence rates for absence of screening were found in women 18-24 and 60-69 years of age, single, and with low income and low schooling. The prevalence rates were consistent with findings from other studies, highlighting the need for greater intervention in the group of women most vulnerable to cervical cancer incidence and mortality.

Maria Fernanda de Sousa Oliveira Borges

2012-06-01

257

Prevalência do exame preventivo de câncer do colo do útero em Rio Branco, Acre, Brasil, e fatores associados à não-realização do exame / Prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and factors associated with non-participation in screening  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O objetivo do estudo foi determinar a prevalência autorreferida do exame preventivo de câncer do colo uterino em Rio Branco, Acre, Brasil, e avaliar fatores associados com a não realização do exame. Trata-se de estudo transversal de base populacional, composto por 772 mulheres de 18 a 69 anos reside [...] ntes em Rio Branco, no período 2007 a 2008. Os dados foram analisados no programa Stata 10.0 e estimadas razões de prevalências a partir da regressão multivariada de Poisson. O percentual de mulheres na população alvo que relatou pelo menos um exame nos últimos três anos foi de 85,3%, com acentuada utilização do Sistema Único de Saúde (72,8%). Foram encontradas razões de prevalência estatisticamente significativas quanto à ausência do exame em mulheres de 18 a 24 anos, de 60 a 69 anos, solteiras, com menor renda e baixa escolaridade. As magnitudes encontradas nas razões de prevalência foram consistentes com achados de outros estudos, apontando maior necessidade de intervenção no grupo de mulheres mais vulneráveis à incidência e mortalidade por câncer do colo do útero. Abstract in english The objective of the study was to determine the self-reported prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and to analyze factors associated with non-participation in screening. A population-based cross-sectional study with a sample of 772 women 18 to 69 years of [...] age and living in Rio Branco was conducted in 2007 and 2008. Data were analyzed with Stata 10.0, and prevalence rates were estimated with Poisson multivariate regression (95%CI). 85.3% of women reported at least one cervical cancer screening test in the previous three years. The majority of women (72.8%) were screened in the Brazilian Unified National Health System. After adjusting for selected variables, statistically significant prevalence rates for absence of screening were found in women 18-24 and 60-69 years of age, single, and with low income and low schooling. The prevalence rates were consistent with findings from other studies, highlighting the need for greater intervention in the group of women most vulnerable to cervical cancer incidence and mortality.

Maria Fernanda de Sousa Oliveira, Borges; Leila Maria Geromel, Dotto; Rosalina Jorge, Koifman; Margarida de Aquino, Cunha; Pascoal Torres, Muniz.

258

Prevalência do exame preventivo de câncer do colo do útero em Rio Branco, Acre, Brasil, e fatores associados à não-realização do exame / Prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and factors associated with non-participation in screening  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: Portuguese Abstract in portuguese O objetivo do estudo foi determinar a prevalência autorreferida do exame preventivo de câncer do colo uterino em Rio Branco, Acre, Brasil, e avaliar fatores associados com a não realização do exame. Trata-se de estudo transversal de base populacional, composto por 772 mulheres de 18 a 69 anos reside [...] ntes em Rio Branco, no período 2007 a 2008. Os dados foram analisados no programa Stata 10.0 e estimadas razões de prevalências a partir da regressão multivariada de Poisson. O percentual de mulheres na população alvo que relatou pelo menos um exame nos últimos três anos foi de 85,3%, com acentuada utilização do Sistema Único de Saúde (72,8%). Foram encontradas razões de prevalência estatisticamente significativas quanto à ausência do exame em mulheres de 18 a 24 anos, de 60 a 69 anos, solteiras, com menor renda e baixa escolaridade. As magnitudes encontradas nas razões de prevalência foram consistentes com achados de outros estudos, apontando maior necessidade de intervenção no grupo de mulheres mais vulneráveis à incidência e mortalidade por câncer do colo do útero. Abstract in english The objective of the study was to determine the self-reported prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and to analyze factors associated with non-participation in screening. A population-based cross-sectional study with a sample of 772 women 18 to 69 years of [...] age and living in Rio Branco was conducted in 2007 and 2008. Data were analyzed with Stata 10.0, and prevalence rates were estimated with Poisson multivariate regression (95%CI). 85.3% of women reported at least one cervical cancer screening test in the previous three years. The majority of women (72.8%) were screened in the Brazilian Unified National Health System. After adjusting for selected variables, statistically significant prevalence rates for absence of screening were found in women 18-24 and 60-69 years of age, single, and with low income and low schooling. The prevalence rates were consistent with findings from other studies, highlighting the need for greater intervention in the group of women most vulnerable to cervical cancer incidence and mortality.

Maria Fernanda de Sousa Oliveira, Borges; Leila Maria Geromel, Dotto; Rosalina Jorge, Koifman; Margarida de Aquino, Cunha; Pascoal Torres, Muniz.

259

Uterine Leiomyoma: Hysterosalpingographic Appearances  

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Full Text Available Uterine leiomyoma is the most common benign tumor of genital tract. The etiology of myomasis unknown. Leiomyoma shows a broad spectrum of radiographic appearances depending on thenumber, size, and location of the tumor. The diagnostic method for uterine leiomyomas is basedprimarily on the clinical situation. Despite of the varied diagnostic options such as; transvaginalsonography, sonohysterography, hysteroscopy, laparoscopy and MRI; hysterosalpingography isstill one of the valuable imaging methods for identification of uterine leiomyoma.The various features of the proved leiomyoma are illustrated in this pictorial review. The incidence,risk factors and clinical features will also be discussed briefly.

Firoozeh Ahmadi

2008-01-01

260

Erosive gastritis  

International Nuclear Information System (INIS)

Erosive gastritis is a well-defined radiologic and endoscopic entity. It is one of the common causes of upper gastrointestinal bleeding, yet it is seldom diagnosed and often confused with a number of other diseases. This communication re-emphasizes the characteristic endoscopic and radiologic features of erosive gastritis and its differential diagnosis. Two representative cases are reported. (orig.)

 
 
 
 
261

Cervical cerclage.  

Science.gov (United States)

Cervical cerclage is an obstetric procedure performed for prevention of prematurity. Cerclage was first introduced by Drs Shirodkar and McDonald in the mid-1950s for women with repeated second trimester losses and cervical changes in current pregnancy. Currently, cerclage placement is based on 3 common indications in singleton gestations, including history-indicated (prior multiple early preterm births or second trimester losses), ultrasound-indicated (cervical length <25 mm before 24-wk gestational age in women with prior spontaneous preterm birth) and physical examination-indicated (cervical dilation on manual or physical examination before 24 wk). PMID:24979354

Suhag, Anju; Berghella, Vincenzo

2014-09-01

262

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... a young woman. She's 31 years old. She has very symptomatic uterine fibroids, very heavy menstrual periods. ... is a catheter, very similar to what he has in the vessel. And if I show you, ...

263

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... a little background. Hysterectomies are the commonest performed surgery in the United States. And the commonest reason that that surgery occurs is for uterine fibroids. Over the past ...

264

Uterine ruptures in Yemen.  

Directory of Open Access Journals (Sweden)

This study confirms high incidence of such serious preventable obstetrical problem. Poor antenatal and intranatal care, poor provision of health service and low socio-economic standard are the main factors contributing to uterine rupture.

Abdalla E. Diab

2005-02-01

265

[Cervical myomectomy by laser CO2. Report of two cases].  

Science.gov (United States)

Cervical localization of uterine fibroids is an uncommon event and vaginal surgery by cold knife is the current therapeutic approach. Two patients with cervical fibroids underwent laser CO2 excision under colposcopic guidance, using local anesthesia and in outpatient setting. The absence of intra- and post-surgical complications and the successful therapeutical results prove that laser CO2 surgery could be an alternative treatment in selected cases. PMID:12364889

Penna, C; Fallani, M G; Fambrini, M; Galassi, D; Basile, V; Marchionni, M

2002-10-01

266

Dysfunctional Uterine Bleeding  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Dysfunctional uterine bleeding (DUB) is defined as abnormal uterine bleeding that results from an ovarian endocrinopathy. It may be associated with ovulatory and anovulatory cycles. The diagnosis of DUB depends on a thorough history and physical examination to exclude organic disorders. In older women, endometrial biopsy should be done before starting therapy. The treatment depends on an understanding of the menstrual cycle. In less urgent cases, anovulatory cycles are managed using progester...

Livingstone, Verity H.

1987-01-01

267

Uterine fibroids: current perspectives  

Directory of Open Access Journals (Sweden)

Full Text Available Aamir T Khan,1 Manjeet Shehmar,1 Janesh K Gupta21Birmingham Women's Hospital, Edgbaston, Birmingham, UK; 2Academic Department of Obstetrics and Gynaecology, University of Birmingham, Birmingham, UKAbstract: Uterine fibroids are a major cause of morbidity in women of a reproductive age (and sometimes even after menopause. There are several factors that are attributed to underlie the development and incidence of these common tumors, but this further corroborates their relatively unknown etiology. The most likely presentation of fibroids is by their effect on the woman's menstrual cycle or pelvic pressure symptoms. Leiomyosarcoma is a very rare entity that should be suspected in postmenopausal women with fibroid growth (and no concurrent hormone replacement therapy. The gold standard diagnostic modality for uterine fibroids appears to be gray-scale ultrasonography, with magnetic resonance imaging being a close second option in complex clinical circumstances. The management of uterine fibroids can be approached medically, surgically, and even by minimal access techniques. The recent introduction of selective progesterone receptor modulators (SPRMs and aromatase inhibitors has added more armamentarium to the medical options of treatment. Uterine artery embolization (UAE has now been well-recognized as a uterine-sparing (fertility-preserving method of treating fibroids. More recently, the introduction of ultrasound waves (MRgFUS or radiofrequency (VizAblate™ and Acessa™ for uterine fibroid ablation has added to the options of minimal access treatment. More definite surgery in the form of myomectomy or hysterectomy can be performed via the minimal access or open route methods. Our article seeks to review the already established information on uterine fibroids with added emphasis on contemporary knowledge.Keywords: leiomyoma, menorrhagia, ultrasonography, selective progesterone receptor modulators, uterine artery embolization, myomectomy

Khan AT

2014-01-01

268

Effective salvage of acute massive uterine bleeding using intrauterine balloon tamponade in a uterine adenomyosis patient on dienogest.  

Science.gov (United States)

We present the case of a 37-year-old nulliparous woman in whom acute massive uterine bleeding during dienogest therapy was successfully treated using intrauterine balloon tamponade. Abnormal uterine bleeding and several cases of profuse bleeding causing severe anemia in association with dienogest therapy have been reported, but this is the first reported case involving hypovolemic shock. While successful control of postpartum hemorrhage with intrauterine balloon tamponade has been well described, applications for non-obstetric bleeding, particularly in the presence of underlying diseases, such as adenomyosis, have only rarely been reported. This procedure can be easily, promptly, and safely implemented without analgesia, anesthesia, or laparotomy; it can be used with a minimally dilated external cervical os or narrow uterine cavity; and it can preserve fertility. PMID:23003209

Nishino, Kimihiro; Hayashi, Kazumasa; Chaya, Jyunya; Kato, Noriko; Yamamuro, Osamu

2013-03-01

269

Cervical Cancer  

Science.gov (United States)

... sheet about cervical cancer is part of the Centers for Disease Control and Prevention’s (CDC) Inside Knowledge: Get the Facts About Gynecologic ... more information about cervical and other gynecologic cancers? Centers for Disease Control and Prevention: 1-800-CDC-INFO or www.cdc.gov/ ...

270

CRYOTHERAPY IN CERVICAL INTRAEPITHELIAL NEOPLASIA  

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Full Text Available Cryotherapy is a time proven ablative method of treating lower grades of cervical dysplasia. It  is done using compressed CO2 or N2O refrigerant with the aim of creating an ice ball with a depth of freeze denoted by a peripheral margin of 4-5 mm of frost. It is performed using a double freeze or single freeze technique. Currently the double freeze technique of cryotherapy is an accepted treatment for mild and focal moderate dysplasia of the uterine cervix. The success of cryotherapy is determined by five factors : patient anatomy, pathology, equipment, technique and physician skill. Here we have a brief review of cryotherapy as an effective modality in treatment of lower grades of cervical intraepithelial neoplasias.

Naina Kumar

2013-01-01

271

Prediction of lymph node status in uterine cervical cancer with {sup 18}FDG-PET/CT-value of primary tumor uptake; Determination par TEP-TDM au {sup 18}FDG du statut ganglionnaire dans les cancers du col uterin - interet de la mesure du SUV de la tumeur primitive  

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Purpose. To evaluate the value of {sup 18}F-fluoro-2-deoxyglucose (F.D.G.) PET-CT and maximal standardized uptake value (SUV{sub max}) of the primary tumor for lymph node staging in cervical cancer. Materials and methods. This retrospective study involved a series of 18 consecutive patients who had benefited from PET-CT and MRI at initial staging for a stage IB or higher cervical carcinoma. The SUV{sub max} of each primary tumor was measured retrospectively. All patients had been previously treated by radio chemotherapy. Lymph node status was obtained in 12 of 18 cases. Results. The sensitivity and specificity for determining lymph node status was 80 and 86%, respectively, for PET-CT, and 80 and 71% for MRI. In 16.6% of cases, PET-CT revealed unknown sus-diaphragmatic lesions. SUV{sub max} of the primary tumor was significantly higher in the N+ than in the N- group (15.6 {+-}1.6 vs 8.5{+-}3.9, p < 0.01). The optimal threshold was determined to be 10.8 from ROC analysis. Conclusion. When staging with F.D.G. PET-CT, SUV{sub max} of a primary cervical cancer seems to be a good predictor of lymph node status. This could lead to an intensification of treatment for patients whose SUV{sub max} is higher than 10.8. A prospective study would allow to assess a potential benefit of treatment intensification for patients with SUV{sub max} higher than 10.8. (authors)

Merlin, C.; Cachin, F.; Kelly, A.; Mestas, D.; Freitas, D. de; Maublant, J. [Clermont-Ferrand-1 Univ., Centre Jean-Perrin, Service de Medecine Nucleaire, 63 (France)

2008-06-15

272

Dosimetric comparison of IMRT and modulated arc-therapy techniques in the treatment of cervical cancers; Comparaison dosimetrique des techniques de RCMI et d'arctherapie modulee dans le traitement des cancers du col uterin  

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The authors report the dosimetric comparison of two techniques used for the treatment of cervical cancers: the intensity-modulated conformational radiotherapy (IMRT) with static beams and modulated arc-therapy with RapidArc. The treatment plans of 15 patients have been compared. The clinical target volume (CTV) comprises the gross target volume, the cervix, the upper third of the vagina, and ganglionary areas. The previsional target volume comprises the clinical target volume and a one centimetre margin. Organs at risk are rectum, bladder, intestine and bone marrow. Arc-therapy seems to provide a better sparing of intestine that IMRT, while maintaining a good coverage of the previsional target volume and decreasing treatment duration. Short communication

Renard-Oldrini, S.; Charra-Brunaud, C.; Tournier-Rangeard, L.; Huger, S.; Marchesi, V.; Bouziz, D.; Peiffert, D. [Centre Alexis-Vautrin, Nancy (France)

2011-10-15

273

How Are Uterine Fibroids Diagnosed?  

Science.gov (United States)

... Resources and Publications En Español How are uterine fibroids diagnosed? Skip sharing on social media links Share ... probably won’t know that you have uterine fibroids. Sometimes, health care providers find fibroids during a ...

274

Acute puerperal uterine inversion  

International Nuclear Information System (INIS)

Objective: To determine the frequency, causes, clinical presentations, management and maternal mortality associated with acute puerperal inversion of the uterus. Materials and Methods: All the patients who developed acute puerperal inversion of the uterus either in or outside the JPMC were included in the study. Patients of chronic uterine inversion were not included in the present study. Abdominal and vaginal examination was done to confirm and classify inversion into first, second or third degrees. Results: 57036 deliveries and 36 acute uterine inversions occurred during the study period, so the frequency of uterine inversion was 1 in 1584 deliveries. Mismanagement of third stage of labour was responsible for uterine inversion in 75% of patients. Majority of the patients presented with shock, either hypovolemic (69%) or neurogenic (13%) in origin. Manual replacement of the uterus under general anaesthesia with 2% halothane was successfully done in 35 patients (97.5%). Abdominal hysterectomy was done in only one patient. There were three maternal deaths due to inversion. Conclusion: Proper education and training regarding placental delivery, diagnosis and management of uterine inversion must be imparted to the maternity care providers especially to traditional birth attendants and family physicians to prevent this potentially life-threatening condition. (author)

275

Conhecimento das mulheres sobre o câncer cérvico-uterino - DOI: 10.4025/actascihealthsci.v26i2.1582 Women’s knowledge of cervical uterine cancer - DOI: 10.4025/actascihealthsci.v26i2.1582  

Directory of Open Access Journals (Sweden)

Full Text Available O objetivo deste estudo foi verificar o conhecimento que as mulheres têm sobre o exame preventivo do câncer cérvico-uterino, sua importância e os sentimentos delas em relação ao exame, em uma tentativa de melhor compreender a prática da prevenção. Trata-se de estudo descritivo exploratório. As mulheres demonstraram que, em relação ao exame, o medo e a vergonha são os maiores sentimentos. Em relação à importância do exame, a maioria relatou ser a prevenção e a descoberta precoce da doença o fator mais importante. Sobre o conhecimento da doença, relataram ter ouvido falar, visto na TV, mas o medo da doença e até do nome câncer é maior que a necessidade de realizar o exame.O que impede a realização do exame é o medo do resultado e a falta de tempo. Os dados permitiram concluir que é necessário aumentar a cobertura dos exames; orientar as mulheres através de campanhas e, ainda, desmistificar a técnica e os resultados dos mesmos.The aim of this work was to verify women’s knowledge of cervical uterine cancer prevention exam, its importance and women’s feelings towards it. This was done in order to better understand the prevention practice. This is an exploratory descriptive study. The women’s major feelings towards this exam are fear and shame. Regarding this exam importance, most of them said that the prevention and the precocious discovery of the illness are the most important factors. Knowledge of the disease was acquired through conversations and TV programs, even though fear of the disease is greater than the need to undertake the exams. The latter is impaired by fear regarding their result and by lack of time to undertake them. Data show that exam coverage should be broadened; more orientation should be given through campaigns; technique and exam results should be demystified.

Maria Dalva de Barros Carvalho

2004-04-01

276

Cervical Stenosis  

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... the cervix to fertilize the egg. After menopause, cervical stenosis may be present but not cause symptoms. A hematometra or pyometra can cause pain or cause the uterus to bulge. Sometimes women ...

277

Cervical Laminoplasty  

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... A) A side-view MRI scan showing the cervical spine in a patient with spinal stenosis. Notice the grey spinal cord traveling down from the brain in the spinal canal. There are multiple areas of spinal cord compression ...

278

Pure uterine lipoma.  

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Lipomatous tumors of the uterus are unusual, benign neoplasms seen in postmenopausal women. Although many of the mixed-type cases such as lipoleiomyoma and fibrolipoma have been reported, pure uterine lipomas are extremely rare. In the literature, a few cases with pure uterine lipoma have been reported. We first present the advanced magnetic resonance findings of pure uterine lipoma, followed by those of ultrasonography (US) and computed tomography (CT). We markedly detected lipid peaks on the magnetic resonance spectroscopy (MRS) and the apparent diffusion coefficient value to be 0.00 due to chemical-shift effects with diffusion-weighted imaging (DWI). Although pelvic lipomatous tumors can be diagnosed with US and CT, in some cases, further workup may be required to localize the lesion. MRI may yield more valuable data for differential diagnosis. MRS and DWI findings provide additional clues on the nature of the lesion. PMID:17905250

Erdem, Gulnur; Celik, Onder; Karakas, Hakki Muammer; Alkan, Alpay; Hascalik, Seyma

2007-10-01

279

Intensity of cervical inflammatory reaction as a risk factor for recurrence of carcinoma of the uterine cervix in stages IB and IIA / Intensidade da reação inflamatória cervical como fator de risco para recorrência do carcinoma do colo do útero nos estádios IB e IIA  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese CONTEXTO E OBJETIVO: A intensidade da reação inflamatória é citada como possível fator de risco para recorrência do carcinoma do colo do útero (CCU). Alguns autores observaram aumento do risco com reação inflamatória fraca, enquanto outros descreveram o oposto. Este estudo procurou avaliar os fatore [...] s de risco para recorrência do CCU em estádios iniciais (IB e IIA), considerando na análise a reação inflamatória. TIPO DE ESTUDO E LOCAL: Coorte retrospectiva, no Centro de Tratamento e Pesquisa Hospital A. C. Camargo (Hospital do Câncer). MÉTODOS: Estudaram-se 289 pacientes com diagnóstico de CCU (estádios IB e IIA) submetidas à cirurgia radical entre 1980 e 1999. Realizou-se a coleta de dados nos prontuários. Os cortes histológicos dos tumores e dos linfonodos foram revistos em 247 casos. As taxas de sobrevida livre de doença em cinco anos foram calculadas pelo método de Kaplan-Meier e as curvas comparadas pelo teste de log-rank. Para a análise multivariada empregou-se o modelo de riscos proporcionais de Cox. A estimativa do risco de recorrência foi o hazard ratio (HR). RESULTADOS: Registraram-se 43 recorrências. A análise multivariada identificou os seguintes fatores de risco independentes para recorrência: número de linfonodos pélvicos metastáticos (1 linfonodo: HR = 3,3 [1,3-8,3]; 2 ou 3 linfonodos: HR = 5,3 [1,5-18,6]; 4 ou mais linfonodos: HR=7,6 [1,7 - 33,2]), profundidade de invasão do tumor (terço profundo: HR = 2,1 [1,1-4,1]) e intensidade da reação inflamatória no colo do útero (ausente ou leve: HR = 2,5 [1,1-5,7]). CONCLUSÃO: Este estudo identificou a reação inflamatória ausente ou de intensidade leve como fatores de risco independentes para recorrência. Os outros fatores de risco foram o número de linfonodos pélvicos metastáticos e a invasão do terço profundo do colo do útero. Abstract in english CONTEXT AND OBJECTIVE: Inflammatory reaction intensity has been indicated as a possible recurrence risk factor in carcinoma of the uterine cervix. Some authors observed greater risk with weak inflammatory reaction, while others described the opposite. This study aimed to evaluate risk factors for in [...] itial-stage uterine cervix carcinoma recurrence (IB and IIA), considering inflammatory reaction intensity. DESIGN AND SETTING: Retrospective cohort at Hospital do Câncer A. C. Camargo. METHODS: 289 patients with diagnosed uterine cervix carcinoma (stages IB and IIA) who underwent radical surgery between 1980 and 1999 were studied. Data were collected from medical records. Histological sections from tumors and lymph nodes could be reviewed in 247 cases. Five-year disease-free survival rates were calculated using the Kaplan-Meier method and curves were compared using the log-rank test. Cox's proportional-hazards model was used for multivariate analysis. Recurrence risk was estimated using hazard ratios (HR). RESULTS: Forty-three recurrences were found. Multivariate analysis identified the following independent recurrence risk factors: number of metastatic pelvic lymph nodes (one lymph node: HR = 3.3 [1.3-8.3]; two or three: HR = 5.3 [1.5-18.6]; four or more: HR = 7.6 [1.7-33.2]), tumor invasion depth (deepest third: HR = 2.1 [1.1-4.1]) and inflammatory reaction intensity in the uterine cervix (absent or slight: HR = 2.5 [1.1-5.7]). CONCLUSION: This study identified that absent or slight inflammatory reaction was an independent risk factor for recurrence. The other risk factors were the number of metastatic pelvic lymph nodes and invasion of the deepest third of the uterine cervix.

José Humberto Tavares Guerreiro, Fregnani; Fernando Augusto, Soares; Pablo Roberto, Novik; Ademar, Lopes; Maria do Rosário Dias de Oliveira, Latorre.

280

Current data on radio chemotherapy and potential of targeted therapies for cervical cancers; Donnees actuelles des associations chimioradiotherapeutiques et place potentielle des therapies ciblees dans les cancers du col uterin  

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The present review represents an up-to-date focus on the particular topic of cervix carcinoma. An exhaustive description of the actual data and the near-future combination of radiotherapy and drugs with the specific potential of targeted therapies are presented. This approach represents one of the next challenges to improve results. Studies conducted in 1999, 2000, and 2002 reported the results of six large-scale prospective randomized trials using concomitant chemo radiation with a significant progression-free and overall survival rate improvement compared to radiotherapy only. These results were confirmed by the two last meta-analyses. Nowadays, the concurrent radio chemotherapy schedule used in the treatment of high risk cervical cancer is a standard practice. More growing evidences suggest that intracellular signal pathways play a significant role in radiation response. Several prognostic factors on tumoral radiosensitivity have been identified, including intracellular signal pathways, in the particular case of cervix carcinoma. Promising results have been obtained in experimental studies assessing the combined use of specific inhibitors and radiotherapy. Based on these data, a number of clinical trials have been started to enhance tumor responses and thus, to decrease the rate of recurrences. (authors)

Magne, N.; Deutsch, E.; Haie-Meder, C. [Institut Gustave-Roussy, Unite de Curietherapie, Dept. de Radiotherapie, 94 - Villejuif (France)

2008-01-15

 
 
 
 
281

A rare case of minimal deviation adenocarcinoma of the uterine cervix in a renal transplant recipient.  

LENUS (Irish Health Repository)

INTRODUCTION: We report the first described case of minimal deviation adenocarcinoma of the uterine cervix in the setting of a female renal cadaveric transplant recipient. MATERIALS AND METHODS: A retrospective review of this clinical case was performed. CONCLUSION: This rare cancer represents only about 1% of all cervical adenocarcinoma.

Fanning, D M

2009-02-03

282

A rare case of minimal deviation adenocarcinoma of the uterine cervix in a renal transplant recipient.  

LENUS (Irish Health Repository)

INTRODUCTION: We report the first described case of minimal deviation adenocarcinoma of the uterine cervix in the setting of a female renal cadaveric transplant recipient. MATERIALS AND METHODS: A retrospective review of this clinical case was performed. CONCLUSION: This rare cancer represents only about 1% of all cervical adenocarcinoma.

Fanning, D M

2012-02-01

283

Uterine arteriovenous malformation.  

Science.gov (United States)

Uterine arteriovenous malformation (AVM) is a rare condition, with fewer than 100 cases reported in the literature. Despite it being rare, it is a potentially life-threatening condition. This case report describes a 33-year-old woman who presented with secondary post-partum hemorrhage. Transabdominal ultrasound (US) of the pelvis showed increased vascularity with multidirectional flow of the uterus and a prominent vessel, located on the left lateral wall. She also had retained product of conception, which complicated the diagnosis. A uterine artery angiogram confirmed an AVM in the fundal region with an early draining vein. Embolisation of the AVM was performed successfully. PMID:23983582

Hashim, Hilwati; Nawawi, Ouzreiah

2013-03-01

284

Incidencia y tendencia de lesiones cervicouterinas en mujeres pinareñas de 10-24 años. 2003-2012 / Incidence and tendency of cervical-uterine lesions in Pinar del Río 10-to-14-year-old women, 2003-2012  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: se han detectado lesiones premalignas y malignas en mujeres menores de 25 años, pero no se conoce exactamente la magnitud del problema en Pinar del Río. Objetivo: evaluar la incidencia y la tendencia de lesiones premalignas y malignas del cuello uterino en mujeres pinareñas menores de [...] 25 años según características demográficas en el período 2003-2012. Material y método: se realizó un estudio retrospectivo, longitudinal para conocer la incidencia anual de lesiones premalignas y malignas del cuello uterino en mujeres pinareñas menores de 25 años. La muestra estuvo conformada por el resultado de las biopsias realizadas a estas jóvenes en ese período. Resultados: la incidencia anual por 10000 mujeres 10-24 años fue de 8.8 para las NIC I; 3,1 en NIC II; 1,6 para las NIC III + CIS, 0.07 para el microinvasor, 0.03 para el invasor Ib y 0.02 para el invasor estadio II. No se detectaron ni estadios superiores de la variedad epidermoide y adenocarcinomas endocervicales. La incidencia anual para cada una de las lesiones mostró una tendencia al incremento sobre todo para las NIC I. De 1198 biopsias realizadas en este grupo etario solamente se detectaron 7 carcinomas epidermoides invasores cervicales en 10 años, 0.7 anuales, con tasa de 5.8 x cada 1000 mujeres de 10-24 años. Conclusiones: la incidencia detectada de lesiones malignas en este grupo no justificaría comenzar la realización del pesquisaje citológico antes de los 25 años, ya que el costo sería alto y el beneficio mínimo. Abstract in english Introduction: malignant and pre-malignant lesions have been localized in women less than 25 years, but the exact enormity of the problem in Pinar del Río is not known. Objective: to evaluate the tendency and incidence of malignant and pre-malign cervical lesions in Pinar women less than 25 years old [...] according to demographic characteristics, in the period 2003-2012. Material and method: a retrospective, cross-sectional study was carried out, in order to know the annual incidence of malign and pre-malign cervical lesions in Pinar women younger than 25 years. The sample comprised the results of biopsies made of those women in that period. Results: the annual incidence in 10,000 women from 10-24 years old was 8.8 for CIN1, 3.1 for CIN2, 1.6 for CIN3 + CIS (carcinoma in situ), 0.07 for de micro-invasive, 0.03 for the invasive Ib, and 0.02 for the invasive stage II. Stages over neither epidermoidal nor endocervical adenocarcinomas were detected. The annual incidence in each lesion proved increasing particularly for NIC1 cases. Out of 1,198 biopsies made on this age group, only 10 invasive epidermoidal carcinomas were detected in ten years, 0.7 annually, with a proportion of 5.8 per 1,000 women between 10-24 years of age. Conclusions: The tendency of malignant lesions detected in this group would not justify starting the cytological screening before the 25 years of age, since the cost would high and the benefit would be minimal.

José Guillermo, Sanabria Negrín; Victor Enrique, Salgueiro Medina; Magalys Brígida, Abreu Mérida; Agustín, Lemus Sarracino; Raydel, Marrero Fernández.

285

Incidencia y tendencia de lesiones cervicouterinas en mujeres pinareñas de 10-24 años. 2003-2012 / Incidence and tendency of cervical-uterine lesions in Pinar del Río 10-to-14-year-old women, 2003-2012  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: se han detectado lesiones premalignas y malignas en mujeres menores de 25 años, pero no se conoce exactamente la magnitud del problema en Pinar del Río. Objetivo: evaluar la incidencia y la tendencia de lesiones premalignas y malignas del cuello uterino en mujeres pinareñas menores de [...] 25 años según características demográficas en el período 2003-2012. Material y método: se realizó un estudio retrospectivo, longitudinal para conocer la incidencia anual de lesiones premalignas y malignas del cuello uterino en mujeres pinareñas menores de 25 años. La muestra estuvo conformada por el resultado de las biopsias realizadas a estas jóvenes en ese período. Resultados: la incidencia anual por 10000 mujeres 10-24 años fue de 8.8 para las NIC I; 3,1 en NIC II; 1,6 para las NIC III + CIS, 0.07 para el microinvasor, 0.03 para el invasor Ib y 0.02 para el invasor estadio II. No se detectaron ni estadios superiores de la variedad epidermoide y adenocarcinomas endocervicales. La incidencia anual para cada una de las lesiones mostró una tendencia al incremento sobre todo para las NIC I. De 1198 biopsias realizadas en este grupo etario solamente se detectaron 7 carcinomas epidermoides invasores cervicales en 10 años, 0.7 anuales, con tasa de 5.8 x cada 1000 mujeres de 10-24 años. Conclusiones: la incidencia detectada de lesiones malignas en este grupo no justificaría comenzar la realización del pesquisaje citológico antes de los 25 años, ya que el costo sería alto y el beneficio mínimo. Abstract in english Introduction: malignant and pre-malignant lesions have been localized in women less than 25 years, but the exact enormity of the problem in Pinar del Río is not known. Objective: to evaluate the tendency and incidence of malignant and pre-malign cervical lesions in Pinar women less than 25 years old [...] according to demographic characteristics, in the period 2003-2012. Material and method: a retrospective, cross-sectional study was carried out, in order to know the annual incidence of malign and pre-malign cervical lesions in Pinar women younger than 25 years. The sample comprised the results of biopsies made of those women in that period. Results: the annual incidence in 10,000 women from 10-24 years old was 8.8 for CIN1, 3.1 for CIN2, 1.6 for CIN3 + CIS (carcinoma in situ), 0.07 for de micro-invasive, 0.03 for the invasive Ib, and 0.02 for the invasive stage II. Stages over neither epidermoidal nor endocervical adenocarcinomas were detected. The annual incidence in each lesion proved increasing particularly for NIC1 cases. Out of 1,198 biopsies made on this age group, only 10 invasive epidermoidal carcinomas were detected in ten years, 0.7 annually, with a proportion of 5.8 per 1,000 women between 10-24 years of age. Conclusions: The tendency of malignant lesions detected in this group would not justify starting the cytological screening before the 25 years of age, since the cost would high and the benefit would be minimal.

José Guillermo, Sanabria Negrín; Victor Enrique, Salgueiro Medina; Magalys Brígida, Abreu Mérida; Agustín, Lemus Sarracino; Raydel, Marrero Fernández.

2014-02-01

286

Fatores de risco para câncer de colo do útero segundo resultados de IVA, citologia e cervicografia / Risk factors for uterine cervical cancer according to results of VIA, cytology and cervicography / Factores de riesgo para cáncer de cuello uterino según resultados de IVA, citología y cervicografía  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Este estudo objetivou avaliar a associação entre fatores de risco para câncer de colo do útero e lesões cervicais por HPV comparando-se os resultados da inspeção visual com o ácido acético (IVA), a citologia e a cervicografia. Realizou-se pesquisa de prevalência com 157 mulheres de um centro de saúd [...] e de Fortaleza, no período de junho a setembro de 2006. Utilizou-se o SPSS para codificar os dados. Realizaram-se inferências por meio de testes estatísticos (?2= quiquadrado e RV= razão de verossimilhança). IVA, cervicografia e citologia obtiveram 43,3%, 10,19% e 3,2% de resultados alterados, respectivamente. As variáveis com importante associação às lesões cervicais na IVA foram: idade menor de 20 anos (p= 0,0001); um ou mais parceiros nos últimos três meses (p= 0,015); uso de contraceptivos (p= 0,0008); presença de corrimento vaginal (p= 0,0001); e processo inflamatório moderado ou acentuado (p= 0,0001). Na citologia: baixa escolaridade (p= 0,0001) e elevado pH (p= 0,001). Não se encontrou associação significante na cervicografia. Abstract in spanish Este estudio objetivó evaluar la asociación entre factores de riesgo para cáncer de cuello de útero y lesiones cervicales por HPV, según comparación entre los resultados de la inspección visual con ácido acético (IVA), citología y cervicografía. Se realizó investigación de prevalencia, con 157 mujer [...] es en un centro de salud de Fortaleza-CE-Brasil, en el período de junio a setiembre de 2006. Se utilizó el SPSS para codificar los datos. Se realizaron inferencias a través de tests estadísticos (?2 = Qui-cuadrado y RV= razón de verosimilitud). La IVA, cervicografía y citología obtuvieron 43,3%, 10,19% y 3,2% de resultados alterados. Las variables con importante asociación a lesiones cervicales en la IVA fueron: edad menor a 20 años (p=0,0001), uno o más parejas en los últimos tres meses (p=0,015), uso de anti-conceptivos (p=0,0008), presencia de vaginitis (p=0,0001) y pH elevado (p=0,001). No se encontró asociación significativa en la cervicografía. Abstract in english This study aimed to evaluate the association between risk factors for uterine cervical neoplasms and cervical lesions by HPV by comparison of the visual inspection with acetic acid (VIA), cytology and cervicography results. A prevalence research was made with 157 women in a health center of Fortalez [...] a in the period of June to September 2006. The SPSS program was used to codify the data. Inferences were made through statistical tests (?2= chi square and LR= likelihood ratio). The VIA, cervicography and cytology obtained 43.3%, 10.19% and 3.2% of altered results. The variables with important association to cervical lesions in the VIA were: aged less than 20 years old (p= 0.0001); one or more partners in the last three months (p= 0.015); use of contraceptives (p = 0.0008); presence of vaginal discharge (p= 0.0001) and moderate or accentuated inflammatory process (p= 0.0001). In the cytology: low instructional level (p= 0.0001) and high pH (p= 0.001). It wasn't found any significant association in the cervicography.

Saiwori de Jesus Silva Bezerra dos, Anjos; Camila Teixeira Moreira, Vasconcelos; Eugênio Santana, Franco; Paulo César de, Almeida; Ana Karina Bezerra, Pinheiro.

287

Fatores de risco para câncer de colo do útero segundo resultados de IVA, citologia e cervicografia Factores de riesgo para cáncer de cuello uterino según resultados de IVA, citología y cervicografía Risk factors for uterine cervical cancer according to results of VIA, cytology and cervicography  

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Full Text Available Este estudo objetivou avaliar a associação entre fatores de risco para câncer de colo do útero e lesões cervicais por HPV comparando-se os resultados da inspeção visual com o ácido acético (IVA, a citologia e a cervicografia. Realizou-se pesquisa de prevalência com 157 mulheres de um centro de saúde de Fortaleza, no período de junho a setembro de 2006. Utilizou-se o SPSS para codificar os dados. Realizaram-se inferências por meio de testes estatísticos (?2= quiquadrado e RV= razão de verossimilhança. IVA, cervicografia e citologia obtiveram 43,3%, 10,19% e 3,2% de resultados alterados, respectivamente. As variáveis com importante associação às lesões cervicais na IVA foram: idade menor de 20 anos (p= 0,0001; um ou mais parceiros nos últimos três meses (p= 0,015; uso de contraceptivos (p= 0,0008; presença de corrimento vaginal (p= 0,0001; e processo inflamatório moderado ou acentuado (p= 0,0001. Na citologia: baixa escolaridade (p= 0,0001 e elevado pH (p= 0,001. Não se encontrou associação significante na cervicografia.Este estudio objetivó evaluar la asociación entre factores de riesgo para cáncer de cuello de útero y lesiones cervicales por HPV, según comparación entre los resultados de la inspección visual con ácido acético (IVA, citología y cervicografía. Se realizó investigación de prevalencia, con 157 mujeres en un centro de salud de Fortaleza-CE-Brasil, en el período de junio a setiembre de 2006. Se utilizó el SPSS para codificar los datos. Se realizaron inferencias a través de tests estadísticos (?2 = Qui-cuadrado y RV= razón de verosimilitud. La IVA, cervicografía y citología obtuvieron 43,3%, 10,19% y 3,2% de resultados alterados. Las variables con importante asociación a lesiones cervicales en la IVA fueron: edad menor a 20 años (p=0,0001, uno o más parejas en los últimos tres meses (p=0,015, uso de anti-conceptivos (p=0,0008, presencia de vaginitis (p=0,0001 y pH elevado (p=0,001. No se encontró asociación significativa en la cervicografía.This study aimed to evaluate the association between risk factors for uterine cervical neoplasms and cervical lesions by HPV by comparison of the visual inspection with acetic acid (VIA, cytology and cervicography results. A prevalence research was made with 157 women in a health center of Fortaleza in the period of June to September 2006. The SPSS program was used to codify the data. Inferences were made through statistical tests (?2= chi square and LR= likelihood ratio. The VIA, cervicography and cytology obtained 43.3%, 10.19% and 3.2% of altered results. The variables with important association to cervical lesions in the VIA were: aged less than 20 years old (p= 0.0001; one or more partners in the last three months (p= 0.015; use of contraceptives (p = 0.0008; presence of vaginal discharge (p= 0.0001 and moderate or accentuated inflammatory process (p= 0.0001. In the cytology: low instructional level (p= 0.0001 and high pH (p= 0.001. It wasn't found any significant association in the cervicography.

Saiwori de Jesus Silva Bezerra dos Anjos

2010-12-01

288

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... a big fibroid. And here is this catheter coming inside the artery, coming all the way down inside the uterine artery. ... if you look up here, there's a vessel coming way up here, outside the uterus. And this, ...

289

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... to steer our way into the artery that supplies the uterus and supplies the fibroids. And we have a couple of ... very abnormal uterine artery, the very rich blood supply. And that is typical of a woman with ...

290

Can we rely on cancer mortality data? Checking the validity of cervical cancer mortality data for Slovenia  

International Nuclear Information System (INIS)

Background. Valid inference on cervical cancer mortality is very difficult since - on the basis of death certificates - it is not always possible to distinguish between cervix, corpus and unspecified uterine cancer deaths. Our aim was to estimate the extent to which cervical cancer as the official cause of death reflects the true mortality from cervical cancer in Slovenia. Material and methods. The data on 2245 deaths from cervix, corpus uteri, and uterus-unspecified cancers for the period 1985-1999 were linked to the Cancer Registry of Slovenia database from the mortality database of Slovenia. Results. Officially, in the period 1985-1999, there were 878 cervical cancer deaths. The comparison of these causes of death with the cancer sites registered in the Cancer Registry revealed that they include only 87.7% patients with a previous diagnosis of cervical cancer. Of 650 corpus uteri cancer deaths, 17. 1 % of patients were registered to have cervical cancer, and of 717 unspecified uterine cancer deaths, 31.4% were registered. Taking into account the correctly identified cervical cancer cases among cervical cancer deaths and misclassified cervical cancer deaths as corpus uteri and unspecified uterine, the corrected number of deaths would be 1106. Conclusions. When evaluating the impact of cervical cancer mortality from national mortality rates, the stated underestimation should be taken into account. However, this does not hold for some other cancers. (author)

291

Prevalence and predictors of cervical involvement in psoriatic spondyloarthropathy.  

Science.gov (United States)

Cervical spondylitis has been reported in 35%-75% of patients with psoriatic arthritis (PsA), and this likely represents the highest frequency of cervical involvement among the spondyloarthropathies. Although 2 patterns of cervical spondylitis have been recognized in PsA, this may reflect a lack of a satisfactory definition of cervical spondylitis in PsA. In a retrospective cross-sectional study, we analyzed the clinical records of 100 consecutive patients recruited at a single university hospital who were diagnosed as having psoriatic spondyloarthropathy on the basis of radiographic sacroiliitis. All patients were involved in a clinicoradiologic study of the cervical column to evaluate the frequency and the predictors of this involvement. Forty-one patients showed radiographic signs of cervical involvement and 24 of them (58.5%) complained of cervical pain and stiffness, whereas 17 (41.5%) had radiologic disease with no symptoms. Arthritis duration (odds ratio, 1.08; 95% confidence interval, 0.99-1.19; p cervical spondylitis development. This study showed a high frequency of cervical spondylitis among patients with psoriatic spondyloarthropathy, confirming previous reports. Although none of our patients developed neurologic sequelae, this report also showed that clinical symptoms of cervical pain and stiffness are not a universal predictor of involvement of the cervical spine, and therefore, patients with PsA with longer disease duration and erosive disease should be screened radiologically to detect those cervical lesions (i.e., atlantoaxial subluxation) with potential catastrophic complications. PMID:17039196

Queiro, Rubén; Sarasqueta, Cristina; Torre, Juan C; Tinture, Tomás; López-Lagunas, Isaac

2002-02-01

292

Radiologic diagnosis and treatment of iatrogenic acquired uterine arteriovenous malformation  

Energy Technology Data Exchange (ETDEWEB)

To analyze gray-scale US, color and duplex Doppler US, and angiographic findings in patients with acquired uterine arteriovenous malformations (AVMs), and to evaluate the usefulness of these modalities in the diagnosis of this disease and the effect of transcatheter arterial embolization in its treatment. During a recent seven-year period, we diagnosed 21 cases of acquired uterine AVM. Nineteen of these patients had a history of causative D and C (between one and seven D and C procedures per patient), one had a history of causative cesarean section, and one had cervical conization. All patients underwent transabdominal and endovaginal gray-scale, color Doppler, and duplex Doppler US and angiography, with therapeutic embolization of bilateral uterine arteries. The majority underwent follow-up Doppler US after embolization. The gray-scale US morphology of uterine AVMs included subtle myometrial inhomogeneity and multiple distinct, small anechoic spaces in the thickened myometrium or endometrium. Color Doppler US showed a tangle of tortuous vessels with multidirectional, high-velocity arterial flow, which was focally or asymmetrically distributed. Duplex Doppler US depicted a waveform of fast arterial flow with low resistance, while angiography demonstrated a complex tangle of vessels supplied by enlarged uterine arteries, in association with early venous drainage during the arterial phase, and staiss of contrast medium within abnormal vasculature. Where AVMs were combined with a pseudoaneurysm, this finding was observed. Transcatheter arterial embolization provided a complete cure, without recurrence. Color and duplex Doppler US in an appropriate modality for the detection and diagnosis of uterine AVMs and for follow-up after embolization. Transcatheter arterial embolization is a safe and effective method of treating this disease.

Kwon, Jung Hyeok [College of Medicine, Keimyung Univ., Taegu (Korea, Republic of)

2002-05-01

293

Radiologic diagnosis and treatment of iatrogenic acquired uterine arteriovenous malformation  

International Nuclear Information System (INIS)

To analyze gray-scale US, color and duplex Doppler US, and angiographic findings in patients with acquired uterine arteriovenous malformations (AVMs), and to evaluate the usefulness of these modalities in the diagnosis of this disease and the effect of transcatheter arterial embolization in its treatment. During a recent seven-year period, we diagnosed 21 cases of acquired uterine AVM. Nineteen of these patients had a history of causative D and C (between one and seven D and C procedures per patient), one had a history of causative cesarean section, and one had cervical conization. All patients underwent transabdominal and endovaginal gray-scale, color Doppler, and duplex Doppler US and angiography, with therapeutic embolization of bilateral uterine arteries. The majority underwent follow-up Doppler US after embolization. The gray-scale US morphology of uterine AVMs included subtle myometrial inhomogeneity and multiple distinct, small anechoic spaces in the thickened myometrium or endometrium. Color Doppler US showed a tangle of tortuous vessels with multidirectional, high-velocity arterial flow, which was focally or asymmetrically distributed. Duplex Doppler US depicted a waveform of fast arterial flow with low resistance, while angiography demonstrated a complex tangle of vessels supplied by enlarged uterine arteries, in association with early venous drainage during the arterial phase, and staiss of contrast medium within abnormal vasculature. Where AVMs were combinnormal vasculature. Where AVMs were combined with a pseudoaneurysm, this finding was observed. Transcatheter arterial embolization provided a complete cure, without recurrence. Color and duplex Doppler US in an appropriate modality for the detection and diagnosis of uterine AVMs and for follow-up after embolization. Transcatheter arterial embolization is a safe and effective method of treating this disease

294

Evidence for benefits from treating cervical ectopy: literature review / Evidências de benefícios no tratamento de ectopia do colo do útero: revisão de literatura  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese CONTEXTO E OBJETIVO: A ectopia do colo do útero é hoje considerada um fenômeno fisiológico, mas parece ainda haver uma forte tendência no sentido da intervenção (tratamento). Este estudo se propõe a realizar revisão da literatura buscando evidências de benefícios conseqüentes ao tratamento da ectopi [...] a. MÉTODOS: Pesquisa nas bases Medical Literature Analysis and Retrieval Sysem Online (Medline), Excerpta Medica Database (Embase), Literatura Latino-Americane e do Caribe em Ciências da Saúde (Lilacs), Biblioteca Cochrane e seis livros especializados. RESULTADOS: A revisão mostrou que: 1) existe provavelmente associação de ectopia com infecção cervical por Chlamydia trachomatis, pelo vírus HPV e maior risco de soroconversão para HIV; 2) existe provavelmente associação entre ectopia e neoplasia intra-epitelial cervical; 3) existe associação com mucorréia e nictúria; 4) não existem evidências sobre associação entre ectopia e câncer de colo do útero nem sobre proteção contra este câncer proporcionada pelo tratamento da ectopia. CONCLUSÕES: 1) Não foram encontrados na literatura dados que justifiquem o tratamento rotineiro da ectopia; 2) O tratamento pode ser utilizado para tratar sintomas associados à ectopia, porém mais sintomas são atribuídos à ectopia do que se pôde confirmar em um estudo controlado; 3) Seriam necessários novos estudos para testar a hipótese de proteção contra o câncer de colo proporcionada pelo tratamento. Abstract in english CONTEXT AND PURPOSE: Uterine cervical ectopy (cervical erosion) is today considered to be a physiological condition, but there still seems to be a strong tendency towards treating it. The purpose of this study was to review the medical literature for evidence regarding benefits from treating cervica [...] l ectopy. METHODS: The following databases were reviewed: Medical Literature Analysis and Retrieval System Online (Medline), Excerpta Medica Database (Embase), Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) and Cochrane Library databases. In addition, six medical textbooks were consulted. RESULTS: The review showed that: 1) there is probably an association between ectopy and higher risk of Chlamydia trachomatis, human papillomavirus and human immunodeficiency virus infection; 4) there is probably an association between ectopy and cervical intraepithelial neoplasia; 5) there is an association between ectopy and mucous discharge and nocturia; and 6) there is no evidence of an association between ectopy and cervical cancer, or of protection against cervical cancer associated with ectopy treatment. CONCLUSIONS: 1) No data were found in the medical literature to support routine treatment for ectopy; 2) Treatment could be recommended for symptom relief, but more symptoms are attributed to ectopy than could be demonstrated in a controlled study; 3) Further studies to test the hypothesis of protection against cervical cancer associated with treatment are necessary.

Luís Carlos, Machado Junior; Ana Sílvia Whitaker, Dalmaso; Heráclito Barbosa de, Carvalho.

295

Cervical Cancer – A Review Article  

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Full Text Available Cervical Cancer is malignant Carcinoma type of cancer originate in cervix region. The cervix is the narrow portion of the uterus where it joins with the top of the vagina. Most cervical cancers are squamous cell carcinomas, arising in the squamous (flattened epithelial cells that line the cervix. Adenocarcinoma, arising in glandular epithelial cells is the second most common type. Very rarely, cancer can arise in other types of cells in the cervix. Cancer refers to a class of diseases in which a cell or a group of cells divide and replicate uncontrollably, intrude into adjacent cells and tissues (invasion and ultimately spread to other parts of the body than the location at which they arose (metastasis (National Cancer Institute 2009. In cervical cancer, (cancer of the uterine cervix, cancer develops in the tissues of the cervix, which is a part of the female reproductive system. The cervix connects the upper body of the uterus to the vagina. The endocervix (the upper part which is close to the uterus is covered by glandular cells, and the ectocervix (the lower part which is close to the vagina is covered by squamous cells. The transformation zone refers to the place where these two regions of the cervix meet (American Cancer Society 2009.

Gunjan Jadon

2012-07-01

296

Low-cost technology for screening uterine cervical cancer / Technique peu coûteuse de dépistage du cancer du col utérin / Tecnología de bajo costo para el cribado del cáncer cervicouterino  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: English Abstract in spanish El cáncer cervicouterino es el tumor maligno más frecuente entre las mujeres de la India. En los países en desarrollo no es posible emprender programas de cribado citológico de ámbito nacional debido a la escasez de personal adiestrado y a la falta de la infraestructura necesaria. La simple inspecci [...] ón visual del cuello uterino detecta los cánceres tempranos con una menor sensibilidad y especificidad que los estudios citológicos. En nuestros estudios anteriores hallamos una tasa de detección relativamente baja de las lesiones cervicouterinas precancerosas. A raíz de ello desarrollamos el Magnivisualizador, un dispositivo de iluminación y aumento cuyo precio es de Rs 1500 (US$ 36). Pretendíamos así mejorar la sensibilidad de la inspección visual simple en la detección de lesiones precancerosas o indicativas de cáncer temprano.De fácil manejo, este instrumento portátil funciona con una pila recargable de 12 V. Consiste en una cámara de luz con un reflector en un lado y un condensador en el otro, equipada con una bombilla halógena de 12 V y 50 W. La cámara tiene en la parte superior, en el extremo del condensador, un cristal de aumento de 2,5 dioptrías y 100 mm de diámetro. Los resultados de la inspección visual simple realizada mediante el Magnivisualizador fueron comparados con los de la colposcopia y/o los informes histológicos en una muestra de 402 mujeres. En total se diagnosticaron histológicamente 73 displasias leves, 76 displasias avanzadas y 59 carcinomas in situ o cánceres invasivos en sus primeras fases. En el caso de las displasias leves, la sensibilidad del análisis citológico fue del 75,3%, y la del Magnivisualizador, del 57,5%. En lo que atañe a las displasias graves y los carcinomas in situ o los cánceres invasivos tempranos, en cambio, la sensibilidad fue del 94,9% con los dos métodos. La tasa de falsos positivos fue del 1,0% en los estudios citológicos, frente al 5,7% con el Magnivisualizador. La especificidad del cribado alcanzó el 94,3% con este último, y el 99% en el análisis citológico.El Magnivisualizador aumentó considerablemente la sensibilidad conseguida mediante la inspección visual simple, no sólo en la detección de carcinomas in situ o de cánceres invasivos tempranos, sino también en el caso de las lesiones precancerosas. Su sensibilidad en la detección de las displasias avanzadas y las lesiones más graves precitadas fue comparable a la del análisis citológico, y disminuyó la tasa de falsos positivos. Además, el costo del examen con Magnivisualizador fue de US$ 0,55, mientras que el del análisis citológico fue de US$ 1,10. La sencilla inspección visual que permite el dispositivo puede realizarse incluso en un centro de atención primaria, sin más requisito que una mesa de exploración Abstract in english We report on an illuminated, low-cost (Rs 1500 (US$ 36)) magnifying device (Magnivisualizer) for detecting precancerous lesions of the uterine cervix. A total of 403 women attending a maternal and child health care clinic who had abnormal vaginal discharge and related symptoms were referred for deta [...] iled pelvic examination and visual inspection by means of the device after the application of 5% (v/v) acetic acid. Pap smears were obtained at the same time. The results were compared with those obtained using colposcopy and/or histology. The Magnivisualizer improved the detection rate of early cancerous lesions from 60%, for unaided visual inspection, to 95%. It also permitted detection of 58% of cases of low-grade dysplasia and 83% of cases of high-grade dysplasia; none of these cases were detectable by unaided visual inspection. For low-grade dysplasia the sensitivity of detection by means of the Magnivisualizer was 57.5%, in contrast with 75.3% for cytological examination. However, the two methodologies had similar sensitivities for higher grades of lesions. The specificity of screening with the Magnivisualizer was 94.3%, while that of cytology was 99%

Aditya, Parashari; Veena, Singh; Ashok, Sehgal; Labani, Satyanarayana; Pushpa, Sodhani; Madan M., Gupta.

297

Low-cost technology for screening uterine cervical cancer / Technique peu coûteuse de dépistage du cancer du col utérin / Tecnología de bajo costo para el cribado del cáncer cervicouterino  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: English Abstract in spanish El cáncer cervicouterino es el tumor maligno más frecuente entre las mujeres de la India. En los países en desarrollo no es posible emprender programas de cribado citológico de ámbito nacional debido a la escasez de personal adiestrado y a la falta de la infraestructura necesaria. La simple inspecci [...] ón visual del cuello uterino detecta los cánceres tempranos con una menor sensibilidad y especificidad que los estudios citológicos. En nuestros estudios anteriores hallamos una tasa de detección relativamente baja de las lesiones cervicouterinas precancerosas. A raíz de ello desarrollamos el Magnivisualizador, un dispositivo de iluminación y aumento cuyo precio es de Rs 1500 (US$ 36). Pretendíamos así mejorar la sensibilidad de la inspección visual simple en la detección de lesiones precancerosas o indicativas de cáncer temprano.De fácil manejo, este instrumento portátil funciona con una pila recargable de 12 V. Consiste en una cámara de luz con un reflector en un lado y un condensador en el otro, equipada con una bombilla halógena de 12 V y 50 W. La cámara tiene en la parte superior, en el extremo del condensador, un cristal de aumento de 2,5 dioptrías y 100 mm de diámetro. Los resultados de la inspección visual simple realizada mediante el Magnivisualizador fueron comparados con los de la colposcopia y/o los informes histológicos en una muestra de 402 mujeres. En total se diagnosticaron histológicamente 73 displasias leves, 76 displasias avanzadas y 59 carcinomas in situ o cánceres invasivos en sus primeras fases. En el caso de las displasias leves, la sensibilidad del análisis citológico fue del 75,3%, y la del Magnivisualizador, del 57,5%. En lo que atañe a las displasias graves y los carcinomas in situ o los cánceres invasivos tempranos, en cambio, la sensibilidad fue del 94,9% con los dos métodos. La tasa de falsos positivos fue del 1,0% en los estudios citológicos, frente al 5,7% con el Magnivisualizador. La especificidad del cribado alcanzó el 94,3% con este último, y el 99% en el análisis citológico.El Magnivisualizador aumentó considerablemente la sensibilidad conseguida mediante la inspección visual simple, no sólo en la detección de carcinomas in situ o de cánceres invasivos tempranos, sino también en el caso de las lesiones precancerosas. Su sensibilidad en la detección de las displasias avanzadas y las lesiones más graves precitadas fue comparable a la del análisis citológico, y disminuyó la tasa de falsos positivos. Además, el costo del examen con Magnivisualizador fue de US$ 0,55, mientras que el del análisis citológico fue de US$ 1,10. La sencilla inspección visual que permite el dispositivo puede realizarse incluso en un centro de atención primaria, sin más requisito que una mesa de exploración Abstract in english We report on an illuminated, low-cost (Rs 1500 (US$ 36)) magnifying device (Magnivisualizer) for detecting precancerous lesions of the uterine cervix. A total of 403 women attending a maternal and child health care clinic who had abnormal vaginal discharge and related symptoms were referred for deta [...] iled pelvic examination and visual inspection by means of the device after the application of 5% (v/v) acetic acid. Pap smears were obtained at the same time. The results were compared with those obtained using colposcopy and/or histology. The Magnivisualizer improved the detection rate of early cancerous lesions from 60%, for unaided visual inspection, to 95%. It also permitted detection of 58% of cases of low-grade dysplasia and 83% of cases of high-grade dysplasia; none of these cases were detectable by unaided visual inspection. For low-grade dysplasia the sensitivity of detection by means of the Magnivisualizer was 57.5%, in contrast with 75.3% for cytological examination. However, the two methodologies had similar sensitivities for higher grades of lesions. The specificity of screening with the Magnivisualizer was 94.3%, while that of cytology was 99%

Aditya, Parashari; Veena, Singh; Ashok, Sehgal; Labani, Satyanarayana; Pushpa, Sodhani; Madan M., Gupta.

2000-08-01

298

Erosion corrosion  

International Nuclear Information System (INIS)

In components of plants whose purpose is to convey media specific types of corrosion are frequently noted at higher velocities of flow among which erosion corrosion plays an important part. It may occur in chemical process plant, machinery, hydraulic plants and specially also in power plants where more substantial material denudation and resulting damage from erosion corrosion is liable to take place in steam generator pipes, preheaters, condensers, turbine casings and pumps. The actual failure of component parts is not infrequently preceded by serious damage in downstream parts of plant that are due to heat-accumulating depositions from corrosion products being brought in. Such damage is as a rule accompanied by a cut in power plant performance through increased loss of pressure and reduced heat transition. Sound knowledge of the mechanism and laws governing corrosion is necessary to reduce the risks associated with damage in operating plants, but especially also in designing new plants. (orig./HP)

299

Staging of carcinoma of the uterine cervix and endometrium  

International Nuclear Information System (INIS)

Carcinoma of the uterine cervix and endometrium are common gynecologic malignancies. Both carcinomas are staged and managed by means of the International Federation of Gynecology and Obstetrics (FIGO) staging system. In uterine cervical cancer, the FIGO staging system is determined preoperatively by limited conventional procedures. Although this system is effective for early stage disease, it has inherent inaccuracies in advanced stage diseases and does not address nodal involvement. CT and MR imaging are widely used as comprehensive imaging modalities to evaluate tumor size and extent, and nodal involvement. MR imaging is an excellent modality for depicting invasive cervical carcinoma and can provide objective measurement of tumor volume, and provides high negative predictive value for parametrial invasion and stage IVA disease. In contrast, endometrial cancer is surgically staged. Beside recognition of the important prognostic factors, including histologic subtype and grade, accurate assessment of the tumor extent on preoperative MR imaging is expected to greatly optimize surgical procedure and therapeutic strategy. Contrast-enhanced MR imaging can offer ''one stop'' examination for evaluating the depth of myometrial invasion cervical invasion and nodal metastases. Evaluation of myometrial invasion on MR imaging may be an alternative to gross inspection of the uterus during the surgery. (orig.)

300

[Inactivation of tumor suppressor genes in uterine cervix carcinogenesis].  

Science.gov (United States)

The importance of inactivation of tumor suppressor genes in the development/progression of carcinomas of the uterine cervix is reviewed. It is well known that HPV-related oncogenes are strongly linked to cervical cancer. However, fewer studies have explored the occurrence of inactivation of tumor suppressor genes in this neoplasia. Genetic deletions affecting tumor suppressor genes are the most common mechanism of inactivation of these genes. Studies using conventional molecular techniques such as restriction fragment length polymorphism (RFLP) and Southern Blot showed low frequency of deletions in cervical carcinomas. Detection of deletions by using RFLP and Southern Blot presents several disadvantages, the most important being the difficulty in analyzing pure tumor cells. More sensitive approaches include tissue microdissection and PCR analysis of micro-satellites. Using these approaches, it has been shown that genetic deletions are, in fact, frequent events in cervical cancers, being detected in up to 95% of the cases. Multiple genetic loci are involved, including chromosomes 3p, 5p, 6p and 11q. Deletions are detected even in precursor lesions (cervical intraepithelial neoplasia, CIN). Some deletions have been correlated with prognostic parameters, such as stage, depth of invasion, and vascular space involvement. It is concluded that cervical carcinogenesis, like in other tumors, is a multistep process, characterized by the accumulation of events including activation of oncogenes, as well as inactivation of tumor suppressor genes. PMID:10835760

Chuaqui, R; Cuello, M; Emmert-Buck, M

1999-12-01

 
 
 
 
301

Cervical Cryotherapy  

Science.gov (United States)

Cervical Cryotherapy What is cryotherapy? Cryotherapy or a freezing treatment is a safe and effective way to destroy abnormal cells that have been found on ... simple procedure to do. Why do I need cryotherapy? Your last Pap smear detected abnormal cells on ...

302

[Cervical cancer].  

Science.gov (United States)

The epidemiologic data demonstrated by SEER clearly show a decrease of cervical cancer over the decades due to widespread cervical cancer screening with a pap smear, although there is currently a shift in the age distribution resulting in an increase of cervical cancer among younger women, and a lower screening rate is a problem, particularly in Japan. Another peculiar trend is an increase of endocervical adenocarcinomas, and the underlying cause of this trend is still unknown. A screening program, employing the Bethesda system terminology and liquid-based cytology, combined with HPV DNA testing and p16(INK4a) immunohistochemistry/ cytochemistry, and a management guideline proposed by ASCCP, has been contributing to the early detection of cervical cancers. However, it should be kept in mind that an HPV-targeted strategy is effective only for squamous lesions, which is mostly HPV-driven neoplasms, and that unusual HPV-negative adenocarcinomas, including gastric, clear cell, and mesonephric types, are a pitfall of HPV DNA testing and vaccination. Therefore, potential biomarkers, which can be applied for both squamous and glandular lesions, are awaited. The gastric type of adenocarcinoma of the cervix, a recently described subtype, is a distinct entity showing an aggressive clinical behavior, and, importantly, is estimated to be more frequent than in western countries. PMID:25151779

Mikami, Yoshiki

2014-06-01

303

Educação em saúde para prevenção do câncer de colo do útero em mulheres do município de Santo Ângelo/RS Education in health for prevention of uterine cervical cancer in women in Santo Ângelo, state of Rio Grande do Sul, Brazil  

Directory of Open Access Journals (Sweden)

Full Text Available No Brasil, o câncer cérvico-uterino constitui importante problema de saúde, pois apresenta alto índice de letalidade entre mulheres de varias idades. O exame citopatológico foi preconizado como medida de prevenção deste tipo de câncer, devendo ser realizado a partir do início da vida sexual. O estudo teve um caráter prático de promover educação em saúde sexual e conhecer o perfil da saúde sexual de mulheres de Santo Ângelo/RS. As palestras abordaram formas de prevenção e identificação de possíveis sintomas da doença. O levantamento do perfil de saúde sexual das participantes foi realizado através da aplicação de um questionário estruturado. Participaram das palestras 140 mulheres com idades entre 15 e 60 anos. Verificou-se que, mesmo enfrentando dificuldades e medo, a maioria delas realiza exame preventivo, motivada por aparecimento de sintomas e pelo hábito de cuidar da saúde. As participantes referiram a importância da integração entre profissionais e educadores em Saúde. O estudo foi direcionado no sentido de dar relevância à promoção da saúde e à prevenção do câncer, buscando evitar a doença e obter melhores condições de vida para as mulheres.In Brazil, cervical uterine cancer is a major public health problem as it has high mortality rate indices among women of different ages. A cytopathological examination is recommended for preventing this type of cancer from the early stages of a woman's reproductive life. The scope of this study was both to give talks on sexual health education and establish the sexual health profile of women from St. Angelo/RS. The lectures included measures for prevention as well as identification of possible symptoms of the disease. The research into the sexual health profile of the participants was conducted by a structured questionnaire applied to 140 women aged between 15 and 60. It was found that even experiencing difficulties and apprehension, the majority of the women performed the preventive examination. The motivation for taking the exam is the appearance of symptoms and the habit of caring for their health. The participants mentioned the importance of health professionals and educators working together. The study sought to promote health and cancer prevention, seeking to avoid the disease and ensure better living conditions for women.

Micheli Renata Casarin

2011-09-01

304

Potentialities in integral care: uterine cervical cancer prevention according to the users of the family health strategy Potencialidades en la atención integral: prevención de cáncer de cuello uterino de acuerdo con las usuarias de la estrategia salud de la familia Potencialidades no atendimento integral: a prevenção do câncer do colo do útero na concepção de usuárias da estratégia saúde da família  

Directory of Open Access Journals (Sweden)

Full Text Available This study aimed to analyze the integral care in the uterine cervical cancer prevention practices in the conception of users of the Family Health Strategy through an exploratory and descriptive research with a qualitative approach. A total of 14 users who performed the Pap smear in December 2002 in four Family Health Units affiliated to Higher Education institutions were selected for the study. Data were collected between April and June 2003. We found that the users analyze and assess the praxis by issuing a value judgment about the care they receive, mainly in terms of light (relational technologies. Concluding, humanized practices provided by professional/team favor integral care, strengthening the bond between users and health services, as well as health promotion.El objetivo de este estudio fue analizar la atención integral dentro de las prácticas de prevención de cáncer de cuello uterino bajo la concepción de las usuarias de la Estrategia Salud de la Familia. Investigación de tipo exploratorio y descriptivo con enfoque cualitativo. Fueron seleccionadas catorce usuarias quienes realizaron el examen de Papanicolao durante el mes de diciembre de 2002, en cuatro Servicios de Salud de la Familia vinculados a Instituciones de Enseñanza Superior. La recolección de datos fue realizados entre abril y junio de 2003. Los resultados demuestran que las usuarias analizan y evalúan la atención recibida formando su opinión, en especial, con relación a las tecnologías leves (de relación. Se concluye que las prácticas humanizadas con responsabilidad profesional/equipo favorecen al cuidado integral, fortaleciendo el vínculo entre las usuarias con los servicios y la promoción de la salud.O objetivo deste estudo foi analisar o atendimento integral nas práticas de prevenção do câncer do colo do útero na concepção de usuárias da Estratégia Saúde da Família. Foi realizada pesquisa exploratória e descritiva com abordagem qualitativa dos dados. Foram selecionadas quatorze usuárias que realizaram o exame Papanicolaou no mês de dezembro de 2002 em quatro Unidades de Saúde da Família, vinculadas a instituições de nível superior. Os dados foram coletados no período de abril a junho de 2003. Como resultado foi observado que as usuárias analisam e avaliam a práxis emitindo juízo de valor à assistência recebida, principalmente, no que se refere às tecnologias leves (relacionais. Conclui-se que práticas humanizadas com responsabilização profissional/equipe favorecem cuidado integral fortalecendo o vínculo das usuárias com os serviços de saúde e a promoção da saúde.

Michele Mandagará de Oliveira

2007-06-01

305

Potentialities in integral care: uterine cervical cancer prevention according to the users of the family health strategy / Potencialidades no atendimento integral: a prevenção do câncer do colo do útero na concepção de usuárias da estratégia saúde da família / Potencialidades en la atención integral: prevención de cáncer de cuello uterino de acuerdo con las usuarias de la estrategia salud de la familia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese O objetivo deste estudo foi analisar o atendimento integral nas práticas de prevenção do câncer do colo do útero na concepção de usuárias da Estratégia Saúde da Família. Foi realizada pesquisa exploratória e descritiva com abordagem qualitativa dos dados. Foram selecionadas quatorze usuárias que rea [...] lizaram o exame Papanicolaou no mês de dezembro de 2002 em quatro Unidades de Saúde da Família, vinculadas a instituições de nível superior. Os dados foram coletados no período de abril a junho de 2003. Como resultado foi observado que as usuárias analisam e avaliam a práxis emitindo juízo de valor à assistência recebida, principalmente, no que se refere às tecnologias leves (relacionais). Conclui-se que práticas humanizadas com responsabilização profissional/equipe favorecem cuidado integral fortalecendo o vínculo das usuárias com os serviços de saúde e a promoção da saúde. Abstract in spanish El objetivo de este estudio fue analizar la atención integral dentro de las prácticas de prevención de cáncer de cuello uterino bajo la concepción de las usuarias de la Estrategia Salud de la Familia. Investigación de tipo exploratorio y descriptivo con enfoque cualitativo. Fueron seleccionadas cato [...] rce usuarias quienes realizaron el examen de Papanicolao durante el mes de diciembre de 2002, en cuatro Servicios de Salud de la Familia vinculados a Instituciones de Enseñanza Superior. La recolección de datos fue realizados entre abril y junio de 2003. Los resultados demuestran que las usuarias analizan y evalúan la atención recibida formando su opinión, en especial, con relación a las tecnologías leves (de relación). Se concluye que las prácticas humanizadas con responsabilidad profesional/equipo favorecen al cuidado integral, fortaleciendo el vínculo entre las usuarias con los servicios y la promoción de la salud. Abstract in english This study aimed to analyze the integral care in the uterine cervical cancer prevention practices in the conception of users of the Family Health Strategy through an exploratory and descriptive research with a qualitative approach. A total of 14 users who performed the Pap smear in December 2002 in [...] four Family Health Units affiliated to Higher Education institutions were selected for the study. Data were collected between April and June 2003. We found that the users analyze and assess the praxis by issuing a value judgment about the care they receive, mainly in terms of light (relational) technologies. Concluding, humanized practices provided by professional/team favor integral care, strengthening the bond between users and health services, as well as health promotion.

Michele Mandagará de, Oliveira; Ione Carvalho, Pinto; Valéria Cristina Christello, Coimbra.

306

Educação em saúde para prevenção do câncer de colo do útero em mulheres do município de Santo Ângelo/RS / Education in health for prevention of uterine cervical cancer in women in Santo Ângelo, state of Rio Grande do Sul, Brazil  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese No Brasil, o câncer cérvico-uterino constitui importante problema de saúde, pois apresenta alto índice de letalidade entre mulheres de varias idades. O exame citopatológico foi preconizado como medida de prevenção deste tipo de câncer, devendo ser realizado a partir do início da vida sexual. O estud [...] o teve um caráter prático de promover educação em saúde sexual e conhecer o perfil da saúde sexual de mulheres de Santo Ângelo/RS. As palestras abordaram formas de prevenção e identificação de possíveis sintomas da doença. O levantamento do perfil de saúde sexual das participantes foi realizado através da aplicação de um questionário estruturado. Participaram das palestras 140 mulheres com idades entre 15 e 60 anos. Verificou-se que, mesmo enfrentando dificuldades e medo, a maioria delas realiza exame preventivo, motivada por aparecimento de sintomas e pelo hábito de cuidar da saúde. As participantes referiram a importância da integração entre profissionais e educadores em Saúde. O estudo foi direcionado no sentido de dar relevância à promoção da saúde e à prevenção do câncer, buscando evitar a doença e obter melhores condições de vida para as mulheres. Abstract in english In Brazil, cervical uterine cancer is a major public health problem as it has high mortality rate indices among women of different ages. A cytopathological examination is recommended for preventing this type of cancer from the early stages of a woman's reproductive life. The scope of this study was [...] both to give talks on sexual health education and establish the sexual health profile of women from St. Angelo/RS. The lectures included measures for prevention as well as identification of possible symptoms of the disease. The research into the sexual health profile of the participants was conducted by a structured questionnaire applied to 140 women aged between 15 and 60. It was found that even experiencing difficulties and apprehension, the majority of the women performed the preventive examination. The motivation for taking the exam is the appearance of symptoms and the habit of caring for their health. The participants mentioned the importance of health professionals and educators working together. The study sought to promote health and cancer prevention, seeking to avoid the disease and ensure better living conditions for women.

Micheli Renata, Casarin; Jaqueline da Costa Escobar, Piccoli.

307

Educação em saúde para prevenção do câncer de colo do útero em mulheres do município de Santo Ângelo/RS / Education in health for prevention of uterine cervical cancer in women in Santo Ângelo, state of Rio Grande do Sul, Brazil  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: Portuguese Abstract in portuguese No Brasil, o câncer cérvico-uterino constitui importante problema de saúde, pois apresenta alto índice de letalidade entre mulheres de varias idades. O exame citopatológico foi preconizado como medida de prevenção deste tipo de câncer, devendo ser realizado a partir do início da vida sexual. O estud [...] o teve um caráter prático de promover educação em saúde sexual e conhecer o perfil da saúde sexual de mulheres de Santo Ângelo/RS. As palestras abordaram formas de prevenção e identificação de possíveis sintomas da doença. O levantamento do perfil de saúde sexual das participantes foi realizado através da aplicação de um questionário estruturado. Participaram das palestras 140 mulheres com idades entre 15 e 60 anos. Verificou-se que, mesmo enfrentando dificuldades e medo, a maioria delas realiza exame preventivo, motivada por aparecimento de sintomas e pelo hábito de cuidar da saúde. As participantes referiram a importância da integração entre profissionais e educadores em Saúde. O estudo foi direcionado no sentido de dar relevância à promoção da saúde e à prevenção do câncer, buscando evitar a doença e obter melhores condições de vida para as mulheres. Abstract in english In Brazil, cervical uterine cancer is a major public health problem as it has high mortality rate indices among women of different ages. A cytopathological examination is recommended for preventing this type of cancer from the early stages of a woman's reproductive life. The scope of this study was [...] both to give talks on sexual health education and establish the sexual health profile of women from St. Angelo/RS. The lectures included measures for prevention as well as identification of possible symptoms of the disease. The research into the sexual health profile of the participants was conducted by a structured questionnaire applied to 140 women aged between 15 and 60. It was found that even experiencing difficulties and apprehension, the majority of the women performed the preventive examination. The motivation for taking the exam is the appearance of symptoms and the habit of caring for their health. The participants mentioned the importance of health professionals and educators working together. The study sought to promote health and cancer prevention, seeking to avoid the disease and ensure better living conditions for women.

Micheli Renata, Casarin; Jaqueline da Costa Escobar, Piccoli.

308

Integralidade na assistência à mulher na prevenção do câncer cérvico-uterino: um estudo de caso / Integrality in women's health in the prevention of cervical-uterine cancer: a case study / Integralidad en la atención a la mujer en la prevención del cáncer de cuello uterino: un estudio de caso  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Realizou-se análise da gestão da atenção, com base na integralidade da assistência à saúde da mulher na prevenção do câncer cérvico-uterino, através de entrevista com duas pacientes atendidas em serviço de saúde da região nordeste do país. Consistiu num estudo de caso onde os dados foram analisados [...] através do Fluxograma Analisador do Modelo de Atenção de um Serviço de Saúde. Em um caso identificou-se a integração dos pontos de atenção, com caráter integral e no outro a fragmentação total desta. No estudo é percebida a importância de maior atenção do gestor no sentido de melhor planejar, organizar e avaliar as ações nos serviços de atenção saúde da mulher, buscando a eficiência, a eficácia e a efetividade, assegurando que os princípios do Sistema Único de Saúde sejam respeitados. Abstract in spanish Este estudio tuvo como objetivo analizar la gerencia de la atención basado en la integralidad de salud de la mujer en la prevención del cáncer de cuello uterino, usando la entrevista con dos pacientes atendidas en un servicio de salud en la región nordeste brasileña. Se constituye en un estudio caso [...] cuyos datos fueron analizados según el Fluxograma Analizador del Modelo de Atención de un servicio de Salud. En uno de los casos se identificó la integración de los puntos de atención; de tipo integral y, en el otro, la fragmentación total de estos. Se percibe en el estudio la importancia de la mayor atención del gerenciador para poder planear mejor, organizar y evaluar las acciones en los servicios de la salud de las mujeres, en la busqueda de los parámetros de la eficiencia, eficacia y efetividad, garantizando que los principios del Sistema Único de Salud sean cumplidos y respetados. Abstract in english This study aimed at analysing attention-based management based upon women's health integration in the prevention of cervical-uterine cancer, using interviews with two patients who were given care in a healthcare service in the northeast region of Brazil. In this case study the data was analysed acco [...] rding to the Analysis Fluxogram of the Healthcare Attention Model. In one of the cases total integration of attention scores was identified; while in the other total fragmentation of attention scores was identified. In this study the relevance of greatest attention was played by the manager in the sense of better planning, organization, and evaluation of the service's interventions in women's healthcare; services that sought efficiency, and effectiveness, assuring that the principles of the Brazilian National Health Care System are respected.

Francisco Rosemiro Guimarães, Ximenes Neto; Isabel Cristina Kowal Olm, Cunha.

309

Uterine fibroid embolization  

International Nuclear Information System (INIS)

Full text: Introduction: Today, after numerous lengthy randomized trials embolization of uterine fibroids has become a standard treatment. Percutaneous embolization of myomas is a micro - invasive surgery, which can be regarded as an alternative to traditional surgery. Although these data 2/3 of the patients were not informed about this treatment option. What you will learn: The uterine embolization is minimal invasive non-surgical procedure. It is an alternative treatment to surgery. Under local anesthesia in the femoral artery puncture reaches the internal iliac artery and uterine arteries. Reached selectively by the catheter and chemicals, which causes clogging, are injected into them. In the vessels that feed fibroids occur a process like an attack, the feeding stops, it starts to shrink and it is replaced by fibrous tissue. The blood vessels of the healthy tissue are different in size and have a plurality of collateral connections as opposed to those of the myoma and thus the blood supply to the normal tissue of the uterus is not distorted. Discussion: Nowadays there are more well- calibrated materials for embolization and those with a particle size of about 700µ are proven as the most successful. The procedure is well tolerated, but after a pain occurs, which has to be covered with anesthetics. Usually pain and metrorrhagia disappear immediately. The fibroids themselves shrink to varying degrees. Hospital stay was significantly shorter than that after surgery, and remained fertile power. Complications are few and rare require further treatment. Multiple nodes are problematic and it is difficult to detect the primary one. A three and six months tracking by MRI is desirable. Conclusion: Embolization of uterine myoma is an established method of treatment primarily on clinical symptoms resulting therefrom. In all patients rapidly disappear metrorrhagia symptoms and morbidity, the volume of the assembly decrease, which together with shorter hospital stays and fertility preservation is well accepted by patients and therefore it is a good alternative to surgery

310

Management of Uterine Sarcomas  

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Full Text Available Uterine sarcomas are rare malignant tumors characterized by a great clinical and histopathological diversity. The aim of this work is to analyze the difficulties of diagnosis, therapeutic and prognosis posed by these tumors. Thirty-seven patients with uterine sarcoma, collected in the service Radiotherapy and Oncology, University Ibn Rochd of Casablanca between January 2000 and December 2007 were included in this study retrospective. The average patient age was 50 years (17-76. The bleeding was present in all patients, isolated in 54% of cases associated with pelvic pain in 24.6% and a mass abdomino-pelvic in seven patients. The average time of evolution was 10 months. The main histological type was found leiomyosarcoma. Twenty four patients in our series underwent total hysterectomy without annexial conservation. The surgery R0 was obtained in 43% of cases. The sarcomas were classified as stage IV in 51.4%. Adjuvant radiotherapy was indicated in 13 patients. After a mean of 20 months, half of patients evaluable presented a local relapse and/or metastatic, the third of cases were tumor progression while complete remission was maintained in 18.5% of cases. Uterine sarcomas are rare malignant mesenchymal tumor, which often occur in women after menopause. The main prognostic factors are hormonal status of the patient, stage clinical, histological type, histological grade and quality surgical excision. The management of uterine sarcomas is multidisciplinary, based mainly on surgery remains the only means of cure. Adjuvant radiotherapy allows decreased risk of local recurrence, with no impact on survival achieved at best 30% at 5 years. The role of chemotherapy remains confirm.

Asmaa Naim

2012-10-01

311

[Uterine Sarcomas - a review].  

Science.gov (United States)

Uterine sarcomas are a heterogeneous group, which constitutes about 8% of malignant uterine tumors. This heterogeneousness and rare occurrence were the main cause of non-uniform therapeutical management. In previously published papers, there were mainly retrospective assessments of the experience of individual centres. The basis of relevant conclusions of the studies, beside their prospectiveness, is the use of unified classification criteria. Currently, a completely new classification of uterine sarcomas is being used, which consists of leiomyosarcoma, endometrial stromal sarcomas and adenosarcomas. For classification of carcinosarcomas, there are valid new criteria of endometrial cancer classification. The basic therapeutic approach of leiomyosarcoma and endometrial stromal sarcomas is a surgical intervention. The gold standard is hysterectomy and salpingooophorectomy. Justifiability of lymphadenectomy is being discussed. For carcinosarcomas, the same recommendations as for the surgical treatment of prognostically unfavourable endometrial carcinoma are valid - hysterectomy, salpingooophorectomy, pelvic and paraaortal lymph node dissection and omentectomy. It is necessary to implement the new classification into clinical practice, to publish and evaluate existing papers, which take into account their basic thesis. Only then it will be possible to create unified therapies. They should be aimed to improve patients survival. PMID:23102195

Kla?ko, M; Babala, P; Mikloš, P; Zuzák, P; Chorváth, M; Ondrušová, M; Ondruš, D

2012-01-01

312

Analysis of TSG101 tumour susceptibility gene transcripts in cervical and endometrial cancers  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Carcinoma of the uterine cervix is a common malignancy among women that has been found to show loss of heterozygosity in the chromosome 11p. Recent studies have localized the TSG101 gene in this region, and also demonstrated a high frequency of abnormalities of this gene in human breast cancer. To determine the role of the TSG101 gene in the carcinogenesis of cervical and uterine carcinoma, 19 cases of cervical carcinoma and five cases of endometrial carcinoma, as well as nearby non-cancerous...

Chang, J-g; Su, T-h; Wei, H-j; Wang, J-c; Chen, Y-j; Chang, C-p; Jeng, C-j

1999-01-01

313

Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters  

Science.gov (United States)

Sarcoma botryoides (embryonal rhabdomyosarcoma) rarely arises in the uterine cervix. We report a case of a 14-year-old female with sarcoma botryoides who presented with prolonged vaginal bleeding and cervical polyp. The biopsy specimen confirmed sarcoma botryoides. The patient underwent radical surgery of the tumor and hysterectomy without adjuvant chemotherapy. The sister of the patient had died previously due to the same diagnosis at the age of 17. We achieved a satisfactory outcome in short-term period with radical surgery and hysterectomy. Presence of sarcoma botryoides of the cervix in two sisters in the family highlights the possible role of genetic factors in the development of sarcoma botryoides. PMID:21278891

Mousavi, Azamsadat

2010-01-01

314

Cervical dysplasia - series (image)  

Science.gov (United States)

... carcinoma in situ, or cervical intraepithelial neoplasia, or dysplasia) requires treatment with ablation therapy, usually in the ... This procedure is performed for more advanced cervical dysplasia, which remains limited to the cervix (cervical intraepithelial ...

315

Effects of intracervical PGE2-gel on myometrial activity and cervical state in first trimester pregnancy  

DEFF Research Database (Denmark)

In 7 primigravidae admitted for first trimester abortion by dilatation and evacuation, 0.5 mg PGE2 in viscous gel (5 patients) or placebo gel (2 patients) was applied intracervically 6 hours prior to the operation. Throughout the treatment period intrauterine pressure was recorded. Application of placebo gel induced no cervical ripening or myometrial activation. In all patients receiving active gel, a marked improvement of the cervical state was induced by the treatment. In three cases, this priming occurred in parallel to minimal changes in myometrial activity, without regular uterine contractions. In two patients, marked uterine activation was registered due to partly extraamniotic application. It is suggested, that the PGE2-gel has a direct effect on the cervical tissues. Further, the risk of partially applying the gel in the extraamniotic space, thus stimulating the myometrium, depends on the gel volume relative to the dimensions of the cervical canal and the application technique.

Forman, Axel; Ulmsten, U

1982-01-01

316

Genome-wide association study of HPV-associated cervical cancer in Japanese women.  

Science.gov (United States)

One of the important factors influencing the development of uterine cervical cancer is human papillomavirus infection in women. Usually, the infecting papillomavirus is eliminated from individuals; however, some retain the virus and this is believed to lead to the development of uterine cervical cancer. It is possible that virus elimination or persistent infection depends on an individual's genetic background. To identify single nucleotide polymorphisms associated with susceptibility to persistent infection or cervical cancer, a genome-wide association study was performed on 226 cases and 186 controls. Some of the single nucleotide polymorphisms showed a P-value?cervical cancer were identified. PMID:24700089

Miura, Kiyonori; Mishima, Hiroyuki; Kinoshita, Akira; Hayashida, Chisa; Abe, Shuhei; Tokunaga, Katsushi; Masuzaki, Hideaki; Yoshiura, Koh-ichiro

2014-07-01

317

Cervical Collagen Concentration within Fifteen Months after Delivery  

DEFF Research Database (Denmark)

OBJECTIVE: Cervical collagen concentration decreases during pregnancy. The increased risk of preterm birth following a short interpregnancy interval may be explained by an incomplete remodeling of the cervix. The objective of this study was to describe the changes in cervical collagen concentration over 15 months following delivery. METHODS: The collagen concentrations were determined in cervical biopsies obtained from 15 women at 3, 6, 9, 12, and 15 months after delivery. RESULTS: The mean cervical collagen concentrations were 50, 59, 63, 65, and 65 % of dry weight (SD 4.2 – 6.5). This increase was statistically significant until month 9, but not between months 9 and 12. CONCLUSIONS: Low collagen concentrations in the uterine cervix may contribute to the association between a short interpregnancy interval and preterm birth.

Sundtoft, Iben; Uldbjerg, Niels

2011-01-01

318

Detection of Merkel cell polyomavirus in cervical squamous cell carcinomas and adenocarcinomas from Japanese patients  

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Abstract Background Merkel cell polyomavirus (MCPyV) was identified originally in Merkel cell carcinoma (MCC), a rare form of human skin neuroendocrine carcinoma. Evidence of MCPyV existence in other forms of malignancy such as cutaneous squamous cell carcinomas (SCCs) is growing. Cervical cancers became the focus of our interest in searching for potentially MCPyV-related tumors because: (i) the major histological type of cervical cancer is the SCC; (ii) the uterine cervix is...

Imajoh Masayuki; Hashida Yumiko; Nemoto Yuiko; Oguri Hiroyoshi; Maeda Nagamasa; Furihata Mutsuo; Fukaya Takao; Daibata Masanori

2012-01-01

319

Effects of the preoperative irradiation using small sourses for cervical cancer  

International Nuclear Information System (INIS)

Twenty four cases of cervical cancer received preoperative irradiation of a total of either 3,000 mgh, 4,500 mgh, and 6,000 mgh using small sourses. Large sections of the excected uterine, were prepared and isodose curves in the neighbourhood of the sourse were drown using glass dosimeter and water phantom. These lines were superimposed on large sections thereby, cervical tissue was examined histopathologically by various stages of absorbed dose. (Mukohata, S.)

320

Detection of congenital uterine malformation by using transvaginal three-dimensional ultrasound.  

Science.gov (United States)

This study assessed the clinical application of transvaginal three-dimensional ultrasound (3D TVUS) in the diagnosis of congenital uterine malformation. A retrospective study was performed on 62 patients with congenital uterine malformation confirmed hysteroscopically and/or laparoscopically. The patients were subjected to transvaginal two-dimensional ultrasound (2D TVUS) and 3D TVUS. The accuracy rate was compared between the two methods. The accuracy rate of 3D TVUS was (98.38%, 61/62), higher than that of 2D TVUS (80.65%, 50/62). 3D TVUS coronal plane imaging could demonstrate the internal shape of the endometrial cavity and the external contour of the uterine fundus. It allowed accurate measurement on the coronary plane, and could three-dimensionally show the image of cervical tube, thereby providing information for the diagnosis of some complex uterine malformation. 3D TVUS imaging can obtain comprehensive information of the uterus malformation, and it is superior to 2D TVUS for the diagnosis of congenital uterine malformations, especially complex uterine anomaly. PMID:25318893

Yu, Li-Li; Zhang, Xuan; Zhang, Ting; Chen, Han-Rong; Wang, Ze-Hua

2014-10-01

 
 
 
 
321

[Cervical pregnancy: an obstetric emergency. A clinical case].  

Science.gov (United States)

Cervical implantation could develop in three different ways. The gestational sac can grow up to external os and interruption may simulate an abnormal menstruation. Theoretically the gestational sac could reach the uterine cavity, with a normal evolution of the pregnancy, even if the implantation of the placenta would be on internal uterine os. Lastly, the ectopic gestational sac developes all in cervical channel with an "obstetrical catastrophe". The incidence of cervical pregnancy presents great differences between authors, from 1:1,000 to 1:95,000 pregnancies; this is due to the variability of diagnostic criteria. A 36 year-old woman, para 1001, came to the emergency unit with painless vaginal bleeding. She was pregnant at 8 weeks of amenorrhoea, and previously undergone a cesarean section. The portio was swollen and bluewish, the external os was opened. The uterus was slightly increased, expecially in the peri-isthmic area; no adnexal mass. The urinary hCG was empty and the sopravaginal cervical area enlarged, invaded by an ectopic trophoblastic proliferation. The majority of obstetricians will never see a cervical pregnancy; the minority who has to treat this pathology wishes to have never seen one. PMID:9808956

Giambanco, L; Chianchiano, N; Palmeri, V; Catalano, G

1998-01-01

322

Erosion Control Measures  

Science.gov (United States)

This lesson will discuss erosion control practices in the agricultural and construction environments. The impact of erosion management practices will be demonstrated with exercises using a USLE calculator.

323

[Uterine fibroids and their treatment].  

Science.gov (United States)

Uterine fibroids are the most common benign disease of women. They occur in women under 30 years of 20-30% for women over 30 years in 50%. The most frequent indication for hysterectomy, uterine fibroids are just. Symptoms of uterine fibroids are various forms of pelvic pain and trouble from the oppression of the surrounding organs, irregular uterine bleeding and fertility disorders resulting from the inability to conceive or recurrent pregnancy loss. Problems of surgical treatment of fibroids applies not only to symptomatic patients who wish to preserve the uterus, but also women who have uterine fibroids negatively affect their reproduction. Treatment of uterine fibroids include monitoring, administration of medications and surgical techniques that preserve either the uterus or not. In recent years the conservatives have extended performance of minimally invasive surgery, which is a common feature of the endoscopic approach, or uterine fibroid devascularization. Gynecologist surgeon must be familiar with the history of the patient and based on history and examination to consider which procedure is best for the patient. PMID:21650001

Hrubosová, E

2011-04-01

324

Posterior Reversible Encephalopathy Syndrome Occurring After Uterine Artery Embolization for Uterine Myoma  

International Nuclear Information System (INIS)

This case report describes posterior reversible encephalopathy syndrome (PRES) occurring after uterine artery embolization (UAE) for uterine myoma. This is the first report of PRES occurring after uterine vascular radiologic intervention. The mechanism by which UAE induced PRES is unclear.

325

Neuroendocrine differentiation in a case of cervical cancer  

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Full Text Available Neuroendocrine neoplasms may occur in the uterine cervix, although rarely; it accounts for 0.5-1% of all malignant tumors of the uterine cervix. A case report of an Ethiopian female presented at the Gynecology Out-Patient Clinic at Jimma University Hospital, complaining from irregular vaginal bleeding over the previous three months. Clinically there was a cauliflower cervical mass; histopathologically it was formed of sheets of small cell tumor; that further showed neuroendocrine differentiation, as demonstrated by chromogranin-A positivity. It is important to differentiate small cell carcinoma from other malignant tumors of the uterine cervix. Morphological features play an important role in making a diagnosis and the immunohistochemistry study can offer an additional useful assistance

Mona Mohamed Rashed

2010-07-01

326

Primary Uterine Cervix Schwannoma: A Case Report and Review of the Literature  

Science.gov (United States)

Schwannoma (neurilemmoma) is a benign peripheral nerve sheath tumor that occurs in a wide variety of locations; however, its finding in the uterine cervix is extremely rare. We report a case of an incidental primary benign cervical schwannoma in a 48-year-old woman. In the English literature, a few cases of primary schwannoma of the cervix have been reported, which include seven cases of primary malignant cervical schwannoma and only two that are benign. These cases are reviewed in the following discussion. PMID:23320233

Tahmasbi, Maryam; Nguyen, Johnny; Ghayouri, Masoumeh; Shan, Yuan; Hakam, Ardeshir

2012-01-01

327

Tipificación del virus papiloma humano (VPH) en lesiones preneoplásicas y carcinoma del cuello uterino en mujeres de la IX Región-Chile Human papilloma virus (HPV) typing in preneoplastic and neoplastic lesions of the uterine cervix in the IX region-Chile  

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Background: Uterine cervical cancer (UCC) is an important public health problem in Chile. Although HPV infection has been established as the main cause of UCC, little is known of its frequency and distribution in our population. Aim: To determine the presence and frequency of viral genotypes in uterine cervical specimens with preneoplastic and neoplastic lesions. Material and Methods: Two nested consensus PCRs followed by identification of amplified product by dot-blo...

Angélica Melo A; Sonia Montenegro H; Terryl Hooper; Italo Capurro V.; Juan Carlos Roa S.; Iván Roa E

2003-01-01

328

Integrative review of the nursing interventions used for the early detection of cervical uterine cancer / Revisión integradora de las intervenciones de enfermería utilizadas para detección precoz del cáncer cervicouterino / Revisão integrativa das intervenções de enfermagem utilizadas para detecção precoce do câncer cérvico-uterino  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Em um programa nacional de combate ao câncer cérvico-uterino (CCU) devem existir quatro elementos básicos: prevenção primária, detecção precoce, diagnóstico/tratamento e cuidados paliativos. Desses, a detecção precoce é a modalidade mais efetiva. Um dos propósitos da Prática Baseada em Evidências é [...] encorajar a utilização de resultados de pesquisa junto à assistência prestada, reforçando a importância da pesquisa para a prática clínica. Esse estudo objetivou avaliar as evidências disponíveis na literatura sobre as intervenções de enfermagem eficazes na detecção precoce do CCU. A seleção dos artigos foi realizada nas bases: Scopus, PubMed, CINAHL, LILACS e Cochrane. A amostra desta revisão constitui-se de 7 artigos, com níveis de evidência 1, 2 ou 3. Tanto as intervenções comportamentais como as cognitivas e sociais mostraram efeitos positivos na detecção precoce do CCU, com destaque para as intervenções cognitivas interativas. Sugere-se, quando adequado, utilizar combinação das intervenções para se obter resultado mais eficaz. Abstract in spanish En un programa nacional de combate al cáncer cervicouterino (CCU) deben existir cuatro elementos básicos: prevención primaria, detección precoz, diagnóstico/tratamiento y cuidados paliativos. De estos, la detección precoz es la modalidad más efectiva. Uno de los propósitos de la Práctica Basada en E [...] videncias es incentivar la utilización de resultados de investigación junto a la asistencia prestada, reforzando la importancia de la investigación para la práctica clínica. Este estudio objetivó evaluar las evidencias disponibles en la literatura sobre las intervenciones de enfermería eficaces en la detección precoz del CCU. La selección de los artículos fue realizada en las bases: Scopus, Pubmed, CINAHL, LILACS y Cochrane. La muestra de esta revisión se constituye de 7 artículos, con niveles de evidencia 1, 2 o 3. Tanto las intervenciones comportamentales, como las cognitivas y sociales mostraron efectos positivos en la detección precoz del CCU, con destaque para las intervenciones cognitivas interactivas. Se sugiere, cuando adecuado, utilizar una combinación de las intervenciones para obtener un resultado más eficaz. Abstract in english In a national program to combat cervical uterine cancer (CUC) four basic elements should exist: primary prevention, early detection, diagnosis/treatment and palliative care. Of these, early detection is the most effective modality. One of the purposes of Evidence-Based Practice (EBP) is to encourage [...] the use of research results with the assistance provided, reinforcing the importance of research for clinical practice. This study aimed to evaluate the evidence available in the literature regarding effective nursing interventions for the early detection of CUC. The selection of articles was performed in the databases: Scopus, PubMed, CINAHL, Lilacs and Cochrane. The sample of this review consisted of seven articles, with evidence levels 1, 2 or 3. The behavioral, cognitive and social interventions, showed positive effects in the early detection of CUC, especially the interactive cognitive interventions. It is suggested, when appropriate, to use a combination of interventions in order to obtain a more effective result.

Camila Teixeira Moreira, Vasconcelos; Marta Maria Coelho, Damasceno; Francisca Elisângela Teixeira, Lima; Ana Karina Bezerra, Pinheiro.

2011-04-01

329

Integrative review of the nursing interventions used for the early detection of cervical uterine cancer Revisión integradora de las intervenciones de enfermería utilizadas para detección precoz del cáncer cervicouterino Revisão integrativa das intervenções de enfermagem utilizadas para detecção precoce do câncer cérvico-uterino  

Directory of Open Access Journals (Sweden)

Full Text Available In a national program to combat cervical uterine cancer (CUC four basic elements should exist: primary prevention, early detection, diagnosis/treatment and palliative care. Of these, early detection is the most effective modality. One of the purposes of Evidence-Based Practice (EBP is to encourage the use of research results with the assistance provided, reinforcing the importance of research for clinical practice. This study aimed to evaluate the evidence available in the literature regarding effective nursing interventions for the early detection of CUC. The selection of articles was performed in the databases: Scopus, PubMed, CINAHL, Lilacs and Cochrane. The sample of this review consisted of seven articles, with evidence levels 1, 2 or 3. The behavioral, cognitive and social interventions, showed positive effects in the early detection of CUC, especially the interactive cognitive interventions. It is suggested, when appropriate, to use a combination of interventions in order to obtain a more effective result.En un programa nacional de combate al cáncer cervicouterino (CCU deben existir cuatro elementos básicos: prevención primaria, detección precoz, diagnóstico/tratamiento y cuidados paliativos. De estos, la detección precoz es la modalidad más efectiva. Uno de los propósitos de la Práctica Basada en Evidencias es incentivar la utilización de resultados de investigación junto a la asistencia prestada, reforzando la importancia de la investigación para la práctica clínica. Este estudio objetivó evaluar las evidencias disponibles en la literatura sobre las intervenciones de enfermería eficaces en la detección precoz del CCU. La selección de los artículos fue realizada en las bases: Scopus, Pubmed, CINAHL, LILACS y Cochrane. La muestra de esta revisión se constituye de 7 artículos, con niveles de evidencia 1, 2 o 3. Tanto las intervenciones comportamentales, como las cognitivas y sociales mostraron efectos positivos en la detección precoz del CCU, con destaque para las intervenciones cognitivas interactivas. Se sugiere, cuando adecuado, utilizar una combinación de las intervenciones para obtener un resultado más eficaz.Em um programa nacional de combate ao câncer cérvico-uterino (CCU devem existir quatro elementos básicos: prevenção primária, detecção precoce, diagnóstico/tratamento e cuidados paliativos. Desses, a detecção precoce é a modalidade mais efetiva. Um dos propósitos da Prática Baseada em Evidências é encorajar a utilização de resultados de pesquisa junto à assistência prestada, reforçando a importância da pesquisa para a prática clínica. Esse estudo objetivou avaliar as evidências disponíveis na literatura sobre as intervenções de enfermagem eficazes na detecção precoce do CCU. A seleção dos artigos foi realizada nas bases: Scopus, PubMed, CINAHL, LILACS e Cochrane. A amostra desta revisão constitui-se de 7 artigos, com níveis de evidência 1, 2 ou 3. Tanto as intervenções comportamentais como as cognitivas e sociais mostraram efeitos positivos na detecção precoce do CCU, com destaque para as intervenções cognitivas interativas. Sugere-se, quando adequado, utilizar combinação das intervenções para se obter resultado mais eficaz.

Camila Teixeira Moreira Vasconcelos

2011-04-01

330

Headache of cervical origin  

International Nuclear Information System (INIS)

The authors recall cervical etiologies of headache. They distinguish on the one hand the cervico-occipital region with minor and major malformations and acquired lesions, and on the other hand the middle and inferior cervical segment. They also recall the original structuralist analysis of the cervical spine and give the example of the ''cervical triplet''. (orig.)

331

[Imaging of premature uterine contraction in vaginal sonography].  

Science.gov (United States)

A collective of 60 patients with clinical diagnosed contractions was vaginosonographically examined. During the ultrasound examination preterm labour was seen in 42 patients. In a control group (n = 50) preterm contractions were not detectable. The average time of the contractions was 88 seconds in the primipara group and 90 seconds in the multipara group and showed no statistical significance. In the group of the primipara a shortening of the cervical length of 17 (+/- 6) mm, in the multipara group 15 (+/- 5) mm was seen under contractions, furthermore a thickening of 8 +/- 4 mm respectively 10 +/- 5 mm. The internal os of the primipara opened 11 +/- 6 mm, of the multipara group 13 +/- 6 mm. The highest incidence of uterine contractions was found in the 32nd week. The paired students t-test showed a significance of p less than 0.001 for the cervical length, thickness and internal os and for the thinning of the dorsal uterine wall, subdividing the parity did not show statistical significance. The vaginosonography is able to help detecting preterm labour. PMID:1496844

Eppel, W; Schurz, B; Frigo, P; Kudielka, I; Wenzl, R; Reinold, E

1992-01-01

332

Biomarkers in Cervical Cancer  

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Full Text Available Cervical cancer, a potentially preventable disease, remains the second most common malignancy in women worldwide. Human papillomavirus (HPV is the single most important etiological agent in cervical cancer, contributing to neoplastic progression through the action of viral oncoproteins, mainly E6 and E7. Cervical screening programs using Pap smear testing have dramatically improved cervical cancer incidence and reduced deaths, but cervical cancer still remains a global health burden. The biomarker discovery for accurate detection and diagnosis of cervical carcinoma and its malignant precursors (collectively referred to as high-grade cervical disease represents one of the current challenges in clinical medicine and cytopathology.

Eun-Kyoung Yim

2006-01-01

333

Bony Calvarium as the Sole Site ofMetastases in Squamous Cell Carcinomaof the Uterine Cervix  

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Full Text Available Isolated skeletal metastasis to the bony calvarium is extremely rare in patients with squamous cell carcinoma of the uterine cervix. We describe the clinical and imaging findings in a case of squamous cell carcinoma of the uterine cervix with metastases tothe bony calvarium as the sole site of metastasis. The patient was a 65-year-old woman with squamous cell carcinoma of the uterine cervix, FIGO stage IIIb, whose initial treatement was chemoradiation therapy. After 22 sessions of external-beam radiation,she developed headaches. On physical examination she had skull bone tenderness. On plain skull X-ray, there were osteolytic bony lesions. Brain MRI showed multiple enhancing skull bone metatstses. Eventually, a whole body bone scintigraphy revealed isolated diffuse increased activity in the bony calvarium. In the literature review, wefound only three similar cases of cervical cancer with scalp metastases and involvement of the bony calvarium.

Mohammad Mohammadianpanah

2010-10-01

334

Patterns of uterine enhancement with helical CT  

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Objective: The purpose of this study was to evaluate the enhancement characteristics of the normal uterine body and cervix using dynamic contrast-enhanced helical CT. Methods: Thirty-eight women scheduled for pelvic CT for non-gynecologic malignancies underwent dynamic contrast-enhanced helical CT of the pelvis. Data acquisition was during the arterial phase (30-45 s after the start of injection), the parenchymal phase (90-120 s after the start of injection), and delayed phase (3-9 min after the start of injection). The images were evaluated by four radiologists for the pattern of myometrial and cervical enhancement. Correlation was made with the age and menstrual status of the patients. Results: In the uterine body, three types of enhancement were observed. Type 1 enhancement, seen in 16 patients (42%), was characterized by the visualization of a subendometrial zone of enhancement, 30-120 s after the start of injection. Eight of these patients also showed an enhancing zone in the outer myometrium. Both zones were transitory, and in all cases, the uterus became homogeneous in the delayed phase. This pattern was seen predominantly in premenopausal women with a mean age of 34 years. Type 2 enhancement, seen in 17 cases (45%), was defined by the absence of subendometrial enhancement in the early phase. Enhancement was either diffuse from the outset or originated in the outer myometrium. This pattern was seen nearly equally in premenopausal and postmenopausal women with a mean age of 40 years. Type 3 enhancement was seen in five postmenopausal patients (13%) with a mean age of 53 years and was characterized by faint diffuse enhancement. In the cervix, a zonal pattern of enhancement defining inner and outer stroma was seen in 23 patients (61%). Fifteen patients were premenopausal and eight were postmenopausal. Conclusion: In this study, we have shown a transitory zonal distribution of the contrast in the myometrium and cervix using dynamic contrast-enhanced helical CT. The demonstration of these patterns is not constant and depends on individual variables. Of these, the menopausal status and/or age of the patient appear to be most important. While CT is not the primary imaging modality to evaluate the uterus, knowledge of these normal findings might help when confronted with unusual uterine enhancement during routine studies obtained with spiral CT. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

Kaur, H.; Loyer, E.M.; Charnsangavej, C. [Department of Diagnostic Radiology, Box 57, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd. Houston, TX 77030 (United States); Minami, M. [Department of Radiology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113 (Japan)

1998-10-01

335

[Congenital cervical agenesis: pregnancy after transmyometrial embryo transfer].  

Science.gov (United States)

Cervical agenesis is a rare congenital pathology linked to an anomaly of development of the Mullerian system. We described a case report about a 22-year old woman, consulting for infertility, who had a complete cervical agenesis. The first evaluation suggested a 46 XX karyotype and a normal ovarian reserve. The surgical examination confirmed the absence of cervix with impossibility of catheterization. She became pregnant thanks to an in vitro fertilization (IVF) with transmyometrial embryo transfer. Caesarean was decided at 36 weeks of gestation (WG) due to spontaneous uterine contractions. An injection of medroxyprogesterone was made after the placenta delivery in order to warning the partum hemorrhage. The ultrasound examination, realized 15 days after caesarean, underlined a good uterine involution. The surgery by cervico-vaginal anastomosis can be offered to patients because it offers chances of spontaneous pregnancies. But this surgery exposes women to a risk of failure, and of severe complications such as pain or infection, and might end in a hysterectomy. By choosing the transmyometrial transfer by vaginal way, the patient was exposed to the risk of spontaneous miscarriage. It was raising the problem of the uterine evacuation. This delivery after 34 WG is encouraging for the infertility by cervical agenesis. PMID:24842642

Huberlant, S; Tailland, M-L; Poirey, S; Mousty, E; Ripart-Neveu, S; Mares, P; de Tayrac, R

2014-09-01

336

General Information About Uterine Sarcoma  

Science.gov (United States)

... for signs of disease. A Pap test or Pap smear of the cervix is usually done. The doctor ... are abnormal. This procedure is also called a Pap smear. Because uterine sarcoma begins inside the uterus, this ...

337

Risk factors of uterine rupture.  

Directory of Open Access Journals (Sweden)

An Obstetrician should be careful in monitoring the progress of labor in women with previous cesarean delivery to avoid the occurrence of a ruptured uterus. Oxytocin or prostaglandin or both should be used judiciously to prevent catastrophic uterine rupture.

Z. A. Al-Jufairi

2001-08-01

338

Excessive uterine bleeding.  

Science.gov (United States)

Menstrual bleeding that falls outside the range of normal in adolescents is often a cause of great concern for both girls and their families. Often, much of this anxiety can be alleviated with proper anticipatory guidance about menarche and early menstrual bleeding patterns. Eliciting a menstrual history from an adolescent girl is challenging, and the use of concrete methods to chart their patterns and flow, such as menstrual calendars and pictorial bleeding assessment calendar (PBAC) tools, may be helpful. The importance of obtaining a confidential history from the adolescent girl cannot be overestimated. A confidential sexual history is essential so that pregnancy and infectious causes of bleeding are addressed. Not all menstrual bleeding in young girls is attributable to immaturity of the HPO axis. Anovulation and DUB from other clinically relevant conditions in adolescent girls must also be considered. Chief among these is PCOS, which should always be ruled out when a girl presents with excessive bleeding associated with clinical signs of hyperandrogenism, obesity, or insulin resistance. Attention must also be paid to signs or a family history of a bleeding disorder, as vWD is commonly associated with excessive uterine bleeding. Importantly, the laboratory testing for both PCOS and vWD is affected by therapies for the excessive bleeding, and it should be performed before hormonal interventions or blood products are administered or during the placebo phase if treatment has begun. Management goals for excessive uterine bleeding include stabilizing the endometrium and stopping further blood loss, as well as preventing future uncontrolled blood loss. Hormonal stabilization of the endometrium is often helpful regardless of the cause of bleeding and especially in those with hormonally mediated anovulation. New antifibrinolytics, such as tranexamic acid, may also be helpful in the emergent setting and in adolescents with bleeding disorders. PMID:22764555

Talib, Hina J; Coupey, Susan M

2012-04-01

339

Detection of malignant melanoma of the uterine cervix from Papanicolaou smears. A case report.  

Science.gov (United States)

A case of malignant amelanotic melanoma of the uterine cervix in a patient presenting with right hemiparesis and enlarged lymph nodes was diagnosed in Papanicolaou-stained cervical smears showing many melanoma cells. Melanoma cells with bizzare nuclear and cytoplasmic abnormalities, rarely seen in other tumors, helped to establish a positive diagnosis. The diagnosis was confirmed by histopathologic study of the endocervical surgical specimen, including a positive immunoperoxidase staining for S-100 protein. PMID:3544629

Yu, H C; Ketabchi, M

1987-01-01

340

Chromosomal imbalances in four new uterine cervix carcinoma derived cell lines  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Uterine cervix carcinoma is the second most common female malignancy worldwide and a major health problem in Mexico, representing the primary cause of death among the Mexican female population. High risk human papillomavirus (HPV) infection is considered to be the most important risk factor for the development of this tumor and cervical carcinoma derived cell lines are very useful models for the study of viral carcinogenesis. Comparative Genomic Hybridizat...

Vázquez Guelaguetza; Taja Lucía; Arana Rosa Ma; Monroy Alberto; Hidalgo Alfredo; Salcedo Mauricio

2003-01-01

 
 
 
 
341

What Should You Ask Your Doctor about Uterine Sarcoma?  

Science.gov (United States)

... for uterine sarcoma? What should you ask your doctor about uterine sarcoma? It is important for you ... and Staging Treating Uterine Sarcoma Talking With Your Doctor After Treatment What`s New in Uterine Sarcoma Research? ...

342

Imaging of uterine cervix carcinoma  

International Nuclear Information System (INIS)

Imaging of uterine cervix carcinoma has evolved during the last decade. Recent developments in magnetic resonance imaging have expanded the role of MRI in evaluating the pathology of uterine cervix carcinoma. MRI is now the modality of choice for tumor staging, evaluating tumor response to treatment, diagnosing recurrences and for evaluating pregnant patients. MRI images will soon be used to calculate dosimetry for brachytherapy with matching and fusion software. (author)

343

Studies on hyperthermia and radiation treatment of uterine cancer using multicellular tumor spheroid  

International Nuclear Information System (INIS)

Anticancer effects of hyperthermia and radiation on uterine cancer cells were studied using multicellular tumor spheroids and monolayer cultured cells. Cell lines used were SKG-3a(uterine cervical epidermoid carcinoma), HeLa-S3(uterine cervical adenocarcinoma) and HEC-59(uterine corpus adenocarcinoma). 1) All cell lines grown in monolayer culture have similar growth rates, but as spheroids, their growth rate are HeLa-S3>HEC-59>SKG-3a cells. 2) The radiosensitivity of all cell lines in monolayer are as follows according to dose-survival relationships.: HEC-59>HeLa-S3>SKG-3a cells. 3) Survival assay to hyperthermia on SKG-3a and HEC-59 cells resulted in no response from 370 to 410C and in cytotoxity over 420C. There is no defference in sensitivity to hyperthermia between the two types of cells. 4) The responses of three cell lines grown as spheroids in hyperthermia and radiation demonstrated that the combination therapy is not effective on the SKG-3a cell, but induced a 1.3-fold effectiveness ratio in HEC-59 and 1.6-fold in HeLa-S3 cells, i.e. more cytotoxity than with radiation alone. These results suggests that hyperthermia and radiation employed together may be more effective on radioresistant adenocarcinoma cells than on radiosensitive epidermoid carcinoma cells. (author)