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1

Uterine didelphys with cervical incompetence  

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Full Text Available Uterine didelphys represents a uterine malformation where the uterus is present as a paired organ. There is presence of double uterine bodies with two separate cervices, and often a double or septate vagina as well. We report a case of single pregnancy in the right sided uterine body of a didelphic uterus with cervical incompetence.

Aher Gautam S, Gavali Urmila G, Kulkarni Meghana

2013-01-01

2

Carbon ion therapy for uterine cervical cancer  

International Nuclear Information System (INIS)

Between June 1995 and August 2003, the four phase I/II dose escalation studies of carbon ion radiotherapy for locally advanced uterine cancer have been performed. Forty-four patients received carbon ion radiotherapy in 24 fixed fractions over 6 weeks (9403 and 9702) and 36 patients received in 20 fixed fractions over 5 weeks (9704 and 9902). The median tumor size in this population was 6.5 cm in diameter. In the beginning of these studies, 8 patients developed grade 4 late morbidity of the rectum and sigmoid colon. These patients underwent colostomy and they are all alive with disease free except one local recurrence. The technique of cone down irradiation to the primary lesion was improved and now there are no severe morbidity in the rectum and sigmoid colon. On the other hand, the tumor control rate increased as the total dose was escalated. The overall local control rate were 71% and 63% at 5 year for stage IIIB and IVA cervical squamous cell carcinoma, and 54% at 4 year for stage III and IVA cervical adenocarcinoma. Carbon ion radiotherapy is considered to be effective for the bulky squamous cell carcinoma and adenocarcinoma which are hard to cure in conventional radiotherapy. (author)

2004-01-01

3

Reliability of transrectal ultrasonography in diagnosis of uterine cervical carcinoma  

International Nuclear Information System (INIS)

To evaluate the reliability of transrectal ultrasonography (TRUS) to define adult female genital organ and to diagnose and stage the cervical carcinomas. After analysis of normal ultrasonographic anatomy of female pelvis in ten healthy women, I performed TRUS in thirty patients of uterine cervical carcinomas by rotating the 5 MHz electronic linear array transducer(SL2, Siemens, Erlangen, Germany) along the reference sagittal plane in the middle of uterine cervix and vagina. The results of TRUS were analyzed and compared to FIGO, surgical pathology, CT and MRT, ect. TRUS allowed good visualization of the uterus, uterine cervix, parametrium, vagina, anterior rectal wall, walls of the urinary bladder, and uterine cervical carcinomas. The accuracy of staging with TRUS was 83%, compared with the accuracy of 67% for clinical staging according to the criteria of the international Federation of Gynecology and Obstetrics(FIGO). For extent of parametrial involvement, the sensitivity of TRUS was 93%, with the specificity of 86% and the diagnostic accuracy of 89%. The same reliability parameters for clinical evaluation were 71%, 79% and 75% respectively. Above findings suggest that low-cost TRUS could be usefully applied to pretreatment evaluation of patients with uterine cervical carcinoma.

1994-01-01

4

Uterine cervical cancer. Preoperative staging with magnetic resonance imaging  

International Nuclear Information System (INIS)

The treatment of uterine cervical carcinoma is largely dependent on the tumor stage. Despite significant inaccuracies in the clinical examination, uterine cervical cancer remains the only gynecological form of cancer still largely staged according to clinical findings. Although imaging is still not included in the staging the recently published revised FIGO (Federation International de Gynecologie et d'Obstetrique) system encourages the use of modern cross-sectional imaging (magnetic resonance imaging MRI and computed tomography CT). Due to its high soft tissue contrast MRI allows excellent non-invasive assessment of the cervix with direct tumor delineation as well as assessment of the prognosis based on morphological factors. Studies in the literature report an accuracy of 93% for MRI in the preoperative assessment of tumor size and in the differentiation of operable from advanced cervical cancer. Therefore MRI is considered to be the optimal modality for diagnostic evaluation starting from FIGO stage IB1, for radiation therapy planning, and for exclusion of recurrence in follow-up. In this paper we give an overview of the role of magnetic resonance imaging in preoperative staging of uterine cervical cancer. (orig.)

2011-01-01

5

Uterine cervical tubulosquamous polyp resembling a penis.  

UK PubMed Central (United Kingdom)

This case report describes a tubulosquamous polyp resembling a penis in the uterine cervix. A 34-yr-old, gravida 0, para 0, woman showed an 18 × 8 × 5 mm polypoid lesion in the uterine ectocervix. The polyp had a penis-like appearance; the tip looked like glans penis and the middle portion resembled the shaft of the penis. Its surface was covered by squamous epithelium, and tissues resembling those of a urethra, corpus spongiosum penis, and external orifice urethra were observed. Foreskin-like tissues were also observed, although a corpus cavernosum penis was not seen. Skene glands and Cowper glands were also observed. Immunohistochemically, Skene glands and the urethra-like epithelium were focally positive for prostate-specific antigen and/or prostatic acid proteins. Histologically and immunohistochemically, the polypoid lesion overlapped with a tubulosquamous polyp of the vagina and ectopic prostatic tissue of the uterine cervix and encompassed these lesions in the lower female genital tract. The most likely theory of histogenesis is a developmental anomaly and misplacement of Skene glands.

Fukunaga M

2013-07-01

6

Uterine cervical tubulosquamous polyp resembling a penis.  

Science.gov (United States)

This case report describes a tubulosquamous polyp resembling a penis in the uterine cervix. A 34-yr-old, gravida 0, para 0, woman showed an 18 × 8 × 5 mm polypoid lesion in the uterine ectocervix. The polyp had a penis-like appearance; the tip looked like glans penis and the middle portion resembled the shaft of the penis. Its surface was covered by squamous epithelium, and tissues resembling those of a urethra, corpus spongiosum penis, and external orifice urethra were observed. Foreskin-like tissues were also observed, although a corpus cavernosum penis was not seen. Skene glands and Cowper glands were also observed. Immunohistochemically, Skene glands and the urethra-like epithelium were focally positive for prostate-specific antigen and/or prostatic acid proteins. Histologically and immunohistochemically, the polypoid lesion overlapped with a tubulosquamous polyp of the vagina and ectopic prostatic tissue of the uterine cervix and encompassed these lesions in the lower female genital tract. The most likely theory of histogenesis is a developmental anomaly and misplacement of Skene glands. PMID:23722517

Fukunaga, Masaharu

2013-07-01

7

Assessment of Cervical Erosion in Hamedan City, Iran  

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Full Text Available The purpose of this study was to determine the role of socio-economic factors and cytology in cervical erosion. A cross-sectional study involving 410 females in the reproductive age group was conducted in urban health centers in Hamedan city, Iran. Data were collected through interviews with women, gynecological examination in the clinics in the health centers and laboratory tests. Cervical erosion was detected in 68 (16.6%) females. Out of these mild dysplasia was seen in (8.8%) females. High percentages of inflammatory smears (58.8%) were obtained in women with cervical erosion. Cervical erosion was more common in illiterate and women with low literacy status as compared to women with higher education. Majority of cases of cervical erosion were detected in women with high parity. A statistically significant relationship was found between lower socio-economic status and cervical erosion (p< 0.05). Regular cytological screening by Pap smear will help in early detection of carcinoma cervix.

Fatemeh Shobeiri; Mansour Nazari

2007-01-01

8

Recurrent uterine cervical carcinoma: spectrum of imaging findings  

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Uterine cervical carcinoma is one of the most common malignant tumors occurring in females. After primary treatment, patients are usually followed up with CT or MRI and the findings of these modalities may be the first sign of recurrent disease. Because earlier additional treatment by chemotherapy or radiation therapy may improve the prognosis, the early detection of recurrent cervical carcinoma is clinically important. In this article, we review the CT and MR imaging findings of recurrent uterine cervical carcinoma, and assign them to one of four groups: a) recurrence at the primary site, involving the intrapelvic organs, b) extension to the pelvic side-wall, c) metastases to pelvic and extrapelvic lymph nodes, or d) metastases to distant organs. A further contribution of CT and MR imaging is the detection of hydronephrosis due to ureteral obstruction. The cases in each group are illustrated and discussed, and since an awareness of the spectrum of imaging findings of recurrent cervical carcinoma is likely to lead to its early detection, radiologists should be familiar with the information presented. (author)

Choi, Jong Il; Kim, Seung Hyup; Seong, Chang Kyu; Sim, Jung Suk; Lee, Hak Jong; Do, Kyung Hyun [The Institute of Radiation Medicine and the Clinical Research Institute and College of Medicine, Seoul National University, Seoul (Korea, Republic of)

2000-12-01

9

Brain metastasis in patients with uterine cervical cancer.  

UK PubMed Central (United Kingdom)

AIM: The purpose of this study was to describe the features of patients with brain metastasis from cervical cancer. MATERIAL AND METHODS: The medical records of patients with cervical cancer between February 2001 and June 2011 were reviewed retrospectively. Clinical characteristics, symptoms, treatment and survival in patients with brain metastasis were analyzed. RESULTS: ? Eleven patients with brain metastasis from cervical cancer were identified, representing an incidence of brain metastasis in the study population of 0.45%. Median patient age at initial diagnosis of cervical cancer was 50 years (range 33-75 years). Non-squamous cell carcinoma was diagnosed in six (54.5%) of the 11 patients, with small cell carcinoma diagnosed in two patients. Ten of the 11 patients had lung-related metastasis at presentation; eight patients had lung metastasis, one had mediastinal lymph node metastasis, and one had pleural metastasis. The median interval from diagnosis of cervical cancer to identification of brain metastasis was 15.4 months (range 3.4-83.3 months). Nine patients presented with neurologic symptoms, such as headache, nausea, vomiting, seizure and extremity weakness. Initially, six patients received whole brain radiotherapy: three patients received chemotherapy; one underwent surgery; and one patient refused treatment. The median survival time after diagnosis of the brain metastases was 5.9 months (range 0.7-19 months). CONCLUSION: The prognosis after diagnosis of the brain metastasis in patients with uterine cervical cancer is poor. The small cell type and lung metastasis seem to be related with brain metastasis and may be regarded as risk factors.

Hwang JH; Yoo HJ; Lim MC; Seo SS; Kang S; Kim JY; Park SY

2013-01-01

10

Second cancer after radiotherapy of the uterine cervical cancer  

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To study the relative risk of second cancer after radiotherapy, we reviewed 2465 cases of uterine cervical cancer who were treated in our institute from 1962 to 1986 and were followed up for more than 5 years. Among them, 1502 cases were treated by radiotherapy with or without surgery (radiotherapy group), and the remainder were treated by surgery only (surgery only group). We defined second cancer as malignancy that occurred in another organ after an interval of 5 years or more from the end of treatment of the first cancer. The relative risk of second cancer was computed by the person-year method advocated by Schoenberg. Second cancer was observed among 8 cases of the surgery group, whereas 43 cases were observed among the radiotherapy group. The cases were: rectal cancer, 6 cases; bladder cancer, 4 cases. The observed and expected ratio (O/E ratio) was 4.02 in rectal cancer and 7.98 in bladder cancer. This incidence of the both cancers was significantly high in the radiotherapy group. Three of the 6 cases with rectal cancer underwent operation in our institute. The incubation periods between the first and second cancers were from 9 to 21 years. Each case exhibited symptoms of chronic radiation proctitis after radiotherapy for uterine cervical cancer. It is thought necessary to follow up such cases carefully to detect radiation induced cancer. (author).

Koizumi, Tadashi; Soejima, Toshinori; Hirota, Saeko; Obayashi, Kayoko; Ishida, Teruko; Takada, Yoshiki; Yoshida, Shoji; Kimura, Shuji (Hyogo Medical Center for Adults, Akashi (Japan))

1993-09-01

11

Horizontal uterine torsion in the setting of complete cervical and partial vaginal agenesis: a case report.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To report a case in which uterine torsion in a nulligravid female adolescent was noted upon surgical management of complete cervical and partial vaginal agenesis. DESIGN: Case report. SETTING: University hospital. PATIENT(S): A 13-year-old nulligravid adolescent female. INTERVENTION(S): Ultrasound-guided vaginal exploration, diagnostic laparoscopy, and hysterectomy. MAIN OUTCOME MEASURE(S): Uterine torsion as complication of cervical agenesis and its management. RESULT(S): Complete cervical agenesis, hematometra, and resultant 180-degree horizontal uterine torsion and sacral entrapment. CONCLUSION(S): Cervical agenesis can be a risk factor for uterine torsion. Hysterectomy is a common treatment due to resultant hematometra, pelvic pain, and severe endometriosis, although rare case reports show success with uterovaginal recanalization in cases with cervical dysgenesis.

Omurtag K; Session D; Brahma P; Matlack A; Roberts C

2009-05-01

12

KAMPILLAKADI GHRITA IN GARBHASHAYA GREEVA GATA VRANA (CERVICAL EROSION)  

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Full Text Available Certain diseases may not be life threatening but troublesome and irritating to an individual in day to day routine activity. “Cervical erosion” is one among them increasing day by day and demanding greater concern over it. It is a benign condition but if left untreated may leads up to infertility and predisposes to cervical malignancy. Cauterization is the known treatment for cervical erosion but chances of recurrence of the disease are high. Keeping this fact in mind the present clinical study has been undertaken. The total effect of drug was evaluated on the basis of signs and symptoms after completion of therapy. The data obtained in clinical study before and after treatment was expressed in terms of Mean, Standard Deviation (+SD) and Standard Error (+SE). Group-I revealed better results than Group-II over total criteria of assessment.

Dhiman Kamini; Parmar Meena; Dhiman K. S.

2012-01-01

13

Systemic leukocyte alterations are associated with invasive uterine cervical cancer.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The aim of the study was to evaluate blood leukocyte counts in patients with uterine cervical neoplasia. METHODS: Patients treated at a university hospital were reviewed retrospectively. Disease progression was monitored, beginning in 1990 to 2002, for at least 5 years. Blood count parameters included absolute leukocyte, neutrophil and lymphocyte counts, leukocytosis (white blood cells > 10³/?L), neutrophilia (neutrophils ? 70% of leukocytes), lymphopenia (lymphocytes ? 15% of leukocytes), and the neutrophil-lymphocyte ratio (NLR), categorized as less than 5 or 5 or greater. RESULTS: A total of 315 patients were enrolled: 182 (57.8%) with preinvasive neoplasia (cervical intraepithelial neoplasia [CIN] group), 95 (30.1%) with stages I to II (early group), and 38 patients (12.1%) with stages III to IV neoplasia (advanced group). Neutrophil and lymphocyte counts were elevated and reduced, respectively, at advanced stages compared with the CIN group (P < 0.05). Leukocytosis, neutrophilia, lymphopenia, and an NLR of 5 or greater were more frequent at advanced stages compared with the CIN and early-stage groups (P < 0.05). Moreover, neutrophilia was also significantly more frequent at early stage compared with the CIN group. The advanced group with neutrophilia had increased frequency of recidivism and metastasis than patients in the CIN group with neutrophilia (P < 0.05). CONCLUSIONS: Patients with advanced cervical cancer had significantly higher frequency of leukocyte alterations, although they may occur apart from the preinvasive stages. Overall, neutrophilia was the best indicator of cancer invasiveness.

Tavares-Murta BM; Mendonça MA; Duarte NL; da Silva JA; Mutão TS; Garcia CB; Murta EF

2010-10-01

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Contributing factors for bone metastasis in uterine cervical cancer.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The purpose of this study was to describe the clinical characteristics and to assess the contributing factors in patients developing bone metastasis in uterine cervical cancer. METHODS: Two thousand thirteen patients had a diagnosis of uterine cervical cancer at Samsung Medical Center between June 1994 and December 2011. During the study period, 105 patients with bone metastasis were identified, and their clinicopathologic data were investigated retrospectively. RESULTS: Among 105 patients with bone metastasis, 14 patients were excluded and 91 patients were evaluable. The median bone metastasis-free survival was 27 months (range, 0-279 months).The time to bone metastasis was significantly shorter in patients with adenocarcinoma than in patients with squamous cell carcinoma (median duration, 12 vs 29 months; P = 0.016). In addition, it was shorter in patients with stage IIB to stage IV disease than in those with stage I to stage IIA disease (15 vs 22 months; P = 0.02). The median survival after bone metastasis was 10 months, longer in the patients who received radiotherapy (± chemotherapy) than in the patients who received chemotherapy alone as a salvage therapy (12 vs 7 months; P = 0.01). Initial stage, number of bone metastases, location of involved bone, and coexisting metastatic lesion were not associated with the overall survival of the patients. CONCLUSIONS: Our study demonstrates that adenocarcinoma, advanced stage (IIB-IV) and initial multiple bone metastases contribute to earlier bone metastasis. Once bone metastasis was recognized, the survival of these patients was poor and no factors were identified to predict survival of those patients.

Yoon A; Choi CH; Kim HJ; Park JY; Lee YY; Kim TJ; Lee JW; Bae DS; Kim BG

2013-09-01

15

[Cytopathological alterations and risk factors for uterine cervical neoplasm].  

Science.gov (United States)

The aim of the present study was to verify the occurrence of citopathological alterations and risk factors of Uterine Cervical Neoplasm in women attended by SUS--the Public Healthcare System--in a district situated in the North of Paraná State, Brazil from 2001 to 2006. It was a descriptive transversal observational study. The data collection consisted in collection of test results from medical records and interviews. It was achieved 6.356 tests and, 1.02% (65) of the women examined presented alterations. From the tests made 4.869 (70,8%) were from women aged between 25 and 59 years. And 38,5% of the tests presented Cervical Intraepithelial Neoplasm (CIN) I, 32,3% CIN II, 18,5% CIN I and Human Papiloma Virus (HPV). It was interviewed 25 women from the total sample. Most of them presented a risk factor as: smoking habits, sexually transmitted diseases, use of hormonal contraceptive, number of sexual partners, early sexual intercourse. This study concludes that is required educative and more effective actions in order to reduce the alterations, meanly among teenagers. PMID:20586201

de Melo, Simone Cristina Castanho Sabaini; Prates, Letícia; Carvalho, Maria Dalva de Barros; Marcon, Sonia Silva; Pelloso, Sandra Marisa

2009-12-01

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[Cytopathological alterations and risk factors for uterine cervical neoplasm].  

UK PubMed Central (United Kingdom)

The aim of the present study was to verify the occurrence of citopathological alterations and risk factors of Uterine Cervical Neoplasm in women attended by SUS--the Public Healthcare System--in a district situated in the North of Paraná State, Brazil from 2001 to 2006. It was a descriptive transversal observational study. The data collection consisted in collection of test results from medical records and interviews. It was achieved 6.356 tests and, 1.02% (65) of the women examined presented alterations. From the tests made 4.869 (70,8%) were from women aged between 25 and 59 years. And 38,5% of the tests presented Cervical Intraepithelial Neoplasm (CIN) I, 32,3% CIN II, 18,5% CIN I and Human Papiloma Virus (HPV). It was interviewed 25 women from the total sample. Most of them presented a risk factor as: smoking habits, sexually transmitted diseases, use of hormonal contraceptive, number of sexual partners, early sexual intercourse. This study concludes that is required educative and more effective actions in order to reduce the alterations, meanly among teenagers.

de Melo SC; Prates L; Carvalho MD; Marcon SS; Pelloso SM

2009-12-01

17

Results of Radiation Therapy in Stage III Uterine Cervical Cancer  

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Purpose : The aim of this study is to analyze the survival rate, treatment failure and complication of radiation therapy alone in stage III uterine cervical cancer. Materials and Methods : From January 1980 through December 1985, 227 patients with stage II uterine cervical cancer treated with radiation therapy at Kosin Medical Center were retrospectively studied. Among 227 patients, 72 patients(31.7%) were stage IIIa, and 155 patients(68.3%) were stage IIIb according to FIGO classification. Age distribution was 32-71 years(median: 62 years). Sixty nine patients(95.8%) in stage IIIa and 150 patients(96.8%) in stage IIIb were squamous cell carcinoma. Pelvic lymph node metastasis at initial diagnosis was 8 patients (11.1%) in stage IIIa and 29 patients(18.7%) in stage IIIb. Among 72 patients with stage IIIa, 36 patients(50%) were treated with external radiation therapy alone by conventional technique (180-200 cGy/fr). And 36 patients(50%) were treated with external radiation therapy with intracavitary radiotherapy(ICR) with Cs137 sources, and among 155 patients with stage IIIb, 80 patients(51.6%) were treated with external radiation therapy alone and 75 patients(48.4%) were treated with external radiation therapy with ICR. Total radiation doses of stage IIIa and IIIb were 65-105 Gy(median : 78.5 Gy) and 65-125.5 Gy (median :83.5 Gy). Survival rate was calculated by life-table method. Results : Complete response rates were 58.3% (42 patients) in state IIIa and 56.1%(87 patients) in stage Iiib. Overall 5 year survival rates were 57% in stage IIIa and 40% in stage IIIb. Five year survival rates by radiation technique in stage IIIa and IIIb were 64%, 40% in group treated in combination of external radiation and ICR, and 50%, 40% in the group of external radiation therapy alone(P=NS). Five year survival rates by response of radiation therapy in stage IIIa and IIIb were 90%, 66% in responder group, and 10%, 7% in non-responder group (P<0.01). There were statistically no significances of 5 year survival rate by total radiation doses and external radiation doses (40 Gy vs 50 Gy) of whole or true pelvis in stage IIIa and IIIb(P=NS). Treatment failures rates were 40.3%(29 patients) in stage IIIa and 57.4%(89 patients) in stage IIIb, 17 patients (23.6%) in stage IIIa and 46 patients (29.7%) in stage IIIb experienced complications. Total radiation doses more than 85 Gy produced serious complication in both stage IIIa(50%) and Iib(50%), Serious complication rates were higher in group received external radiation doses of 50 Gy than 40 Gy to whole or true pelvis in stage IIIa and IIIb. Serious rectal complication developed in rectal doses more than 65 Gy, and serious bladder complication developed in bladder doses more than 75 Gy. Major cause of death was cachexia due to locoregional failure in both stage IIIa(34.7%) and IIIb(43.9%). Conclusion : From this study, we found that external radiation therapy with ICR was found to have a tendency to be superior to external radiation therapy alone in survival rate, local control rate and complication rate but not different in statistics, and external radiation doses of 50 Gy than 40 Gy tho whole or true pelvis produced serious rectal and bladder complications in stage III uterine cervical cancer.

Moon, Chang Woo; Shin, Byung Chul; Yum, Ha Yong; Jeung, Tae Sig; Yoo, Myung Jin [Kosin University College of Medicine, Seoul (Korea, Republic of)

1995-09-15

18

Radiotherapy results for recurrent uterine cervical cancer after surgery  

International Nuclear Information System (INIS)

To evaluate prognostic factors and survival rates of the patients who received radiation therapy for locally recurrent uterine cervical cancer after curative surgery. Between October 1983 and July 1996, fifty three patients who received radiation therapy for locally recurrent cervical cancer after curative surgery at the Department of Therapeutic Radiology, Kangnam St. Mary's Hospital, The Catholic University of Korea were analysed retrospectively. Age at diagnosis ranged from 33 to 69 years (median 53 years). Pathological analysis showed that forty five (84.9%) patients had squamous cell carcinoma, seven (13.2%) patients had adenocarcinoma, and one (1.9%) patient had adenosquamous cell carcinoma. The interval between hysterectomy and tumor recurrence ranged from 2 months to 25 years (mean 34.4 months). The recurrent sites were vaginal stump in 41 patients (77.4%) and pelvic side wall in 12 patients (22.6%). Recurrent tumor size was divided into two groups: less than 3 cm in 43 patients (81.1%) and more than 3 cm in 10 patients (18.9%). External beam irradiation of whole pelvis was done first up to 46.8 Gy to 50.4 Gy in 5 weeks to 6 weeks, followed by either external beam boost to the recurrent site in 18 patients (34%) or intracavitary irradiation in 24 patients (45.3%). Total dose of radiation ranged from 46.8 Gy to 111 Gy (median 70.2 Gy). Follow up period ranged from 2 to 153 months with a median of 35 months. Overall response rate was 66% (35/53). Among them, six patients (17.1%) relapsed between 7 months and 116 months after radiation therapy (mean 47.7 months). Therefore overall recurrence rate was 45.3%. Overall five-year actuarial survival rate was 78.9% and distant failure rate was 10% (5/50). The significant prognostic factors affecting survival rate were interval between primary surgery and tumor recurrence (p=0.0055), recurrent tumor size (p=0.0039), and initial response to radiation therapy (p=0.0428). Complications were observed in 10 (20%) patients, which included mild to moderate lower gastrointestinal, genitourinary, or skin manifestations. One patient died of pulmonary embolism just after intracavitary irradiation. Radiation therapy is the effective treatment for the patients with locally recurrent cervical cancer after curative surgery. These results suggest that interval between primary surgery and tumor recurrence, recurrent tumor size, and initial response to radiation therapy were significant prognostic factors for recurrent cervical cancer

1983-10-00

19

Results of Radiation Therapy in Stage III Uterine Cervical Cancer  

International Nuclear Information System (INIS)

[en] Purpose : The aim of this study is to analyze the survival rate, treatment failure and complication of radiation therapy alone in stage III uterine cervical cancer. Materials and Methods : From January 1980 through December 1985, 227 patients with stage II uterine cervical cancer treated with radiation therapy at Kosin Medical Center were retrospectively studied. Among 227 patients, 72 patients(31.7%) were stage IIIa, and 155 patients(68.3%) were stage IIIb according to FIGO classification. Age distribution was 32-71 years(median: 62 years). Sixty nine patients(95.8%) in stage IIIa and 150 patients(96.8%) in stage IIIb were squamous cell carcinoma. Pelvic lymph node metastasis at initial diagnosis was 8 patients (11.1%) in stage IIIa and 29 patients(18.7%) in stage IIIb. Among 72 patients with stage IIIa, 36 patients(50%) were treated with external radiation therapy alone by conventional technique (180-200 cGy/fr). And 36 patients(50%) were treated with external radiation therapy with intracavitary radiotherapy(ICR) with Cs137 sources, and among 155 patients with stage IIIb, 80 patients(51.6%) were treated with external radiation therapy alone and 75 patients(48.4%) were treated with external radiation therapy with ICR. Total radiation doses of stage IIIa and IIIb were 65-105 Gy(median : 78.5 Gy) and 65-125.5 Gy (median :83.5 Gy). Survival rate was calculated by life-table method. Results : Complete response rates were 58.3% (42 patients) in state IIIa and 56.1%(87 patients) in stage Iiib. Overall 5 year survival rates were 57% in stage IIIa and 40% in stage IIIb. Five year survival rates by radiation technique in stage IIIa and IIIb were 64%, 40% in group treated in combination of external radiation and ICR, and 50%, 40% in the group of external radiation therapy alone(P=NS). Five year survival rates by response of radiation therapy in stage IIIa and IIIb were 90%, 66% in responder group, and 10%, 7% in non-responder group (P

1995-01-01

20

Results of irradiation therapy for advanced uterine cervical cancer  

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152 patients with advanced uterine cervical cancer (76 in stage III, 47 in stage IV and 29 in recurrence) were treated at Miyagi Seijinbyo Center in fifteen years (1967-1981). Our standard treatment was a combined therapy of 6 MVX ray whole pelvis irradiation and intracavitary radium irradiation (or simple total hysterectomy) The actuarial 5-year-survival rate was 46.0% in stage III, 9.4% in stage IV and 10.3% in recurrence. In stage III, the actuarial 5-year-survival rate in nine cases with external irradiation alone was (22.2%), in 44 cases with intracavitary irradiation and external irradiation 48.7%; in 14 cases with operation and external irradiation 57.1%. No five year survival was found in nine interrupted-irradation cases. Moderate complications in the rectum and/or the urinary bladder were found in eight of 67 (12%) irradiation-completed patients in stage III. Five 5-year-survival cases (two in stage IV and three in recurrence) were reported.

Saito, Haruo; Asakawa, Hiroshi; Otawa, Hirokazu; Nemoto, Kenji; Saito, Hiroyuki (Miyagi Prefectural Adult Disease Center, Natori (Japan))

1983-12-01

 
 
 
 
21

Postirradiation sarcoma (malignant fibrous histiocytoma) following uterine cervical cancer  

International Nuclear Information System (INIS)

A case of postirradiation sarcoma, a malignant fibrous histiocytoma, is described. The tumor occurred in the radiation field (the buttock) 8 years after radiation therapy for keratinizing squamous cell carcinoma of the uterine cervix. The 68-year-old female patient with the inital diagnosis of cervical cancer was treated with pelvic irradiation in 1973. She did well after that with no evidence of disease until 1981 when she developed an enlarging mass in the right buttock within the field of the previous radiation therapy. Microscopically, the tumor at biopsy was composed of pleomorphic histiocyte-like cells, spindle-sphaped cells arranged in a storiform pattern and multinucleated giant cells with bizarre nuclei. Cytodiagnostically, two types of cells, fibroblast-like cells ane histiocyte-like cells, were found. And some cells were considered to be transitional forms, intermediate between fibroblast and histiocytes. Multinucleated pleomorphic giant cells were sometimes seen. Ultrastructurally, the same types of cells were confirmed. These cells contained large numbers of rough endoplasmic reticula with dilated lumens, vacuoles, lysosomal structures, and lipid droplets. (author)

1984-01-01

22

Postirradiation sarcoma (malignant fibrous histiocytoma) following uterine cervical cancer  

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A case of postirradiation sarcoma, a malignant fibrous histiocytoma, is described. The tumor occurred in the radiation field (the buttock) 8 years after radiation therapy for keratinizing squamous cell carcinoma of the uterine cervix. The 68-year-old female patient with the inital diagnosis of cervical cancer was treated with pelvic irradiation in 1973. She did well after that with no evidence of disease until 1981 when she developed an enlarging mass in the right buttock within the field of the previous radiation therapy. Microscopically, the tumor at biopsy was composed of pleomorphic histiocyte-like cells, spindle-sphaped cells arranged in a storiform pattern and multinucleated giant cells with bizarre nuclei. Cytodiagnostically, two types of cells, fibroblast-like cells ane histiocyte-like cells, were found. And some cells were considered to be transitional forms, intermediate between fibroblast and histiocytes. Multinucleated pleomorphic giant cells were sometimes seen. Ultrastructurally, the same types of cells were confirmed. These cells contained large numbers of rough endoplasmic reticula with dilated lumens, vacuoles, lysosomal structures, and lipid droplets. (author).

Noda, Tsuneo; Tomii, Yoshifumi; Saitoh, Shigeru; Ichijo, Motohiko; Ito, Hiroko; Adachi, Hironari; Kawai, Kazuo

1984-10-01

23

Case of metastatic uterine cervical squamous cell carcinoma in the right atrium.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Metastasis of uterine cervical carcinoma to the heart is uncommon and cases with metastasis to the right atrium are especially rare. This type of metastasis occurs in the epicardium and the myocardium in over 90% of cases with a heart metastatic tumor. Most cases of a metastatic tumor in the heart are found by chance during autopsy. CASE REPORT: We present the case of a patient with stage IIa uterine cervical carcinoma who visited our hospital with a chief complaint of arrhythmia 1.9 years after surgical treatment of carcinoma. CT and MRI showed that recurrent metastatic uterine cervical carcinoma had grown from the inferior vena cava upward into the right atrium. CONCLUSION: Although gynecological malignant tumors rarely metastasize to the heart, it is important to consider this possibility in patients with chest symptoms, and to make an early definite diagnosis and give appropriate treatment.

Togo A; Muramatsu T; Tsukada H; Ikeda M; Shida M; Hirasawa T; Maeda H; Mikami M

2013-04-01

24

The role of uterine artery embolization in cervical cancer - single case report.  

Science.gov (United States)

Massive vaginal bleeding represents one of the emergencies that the gynecologists have to deal with. When unresponsive to the haemostatic treatment (local or iv), the bleeding can be stopped by using the uterine artery embolization. It provides visualization of the bleeding site and enables targeted, minimally invasive therapy to achieve hemostasis. We present a case of a patient with cervical cancer associated with massive vaginal bleeding and the beneficial effects of the uterine artery embolization in the therapy management. PMID:22205897

Albu, Simona; Grigoriu, Corina; Vasiliu, Cristina; Olaru, Ioana; Horhoianu, Irina; Grigoras, Mirela; Mihai, Daniela

2011-04-01

25

The role of uterine artery embolization in cervical cancer - single case report.  

UK PubMed Central (United Kingdom)

Massive vaginal bleeding represents one of the emergencies that the gynecologists have to deal with. When unresponsive to the haemostatic treatment (local or iv), the bleeding can be stopped by using the uterine artery embolization. It provides visualization of the bleeding site and enables targeted, minimally invasive therapy to achieve hemostasis. We present a case of a patient with cervical cancer associated with massive vaginal bleeding and the beneficial effects of the uterine artery embolization in the therapy management.

Albu S; Grigoriu C; Vasiliu C; Olaru I; Horhoianu I; Grigoras M; Mihai D

2011-04-01

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Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology  

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To design clear guidelines for the staging and follow-up of patients with uterine cervical cancer, and to provide the radiologist with a framework for use in multidisciplinary conferences. Methods: Guidelines for uterine cervical cancer staging and follow-up were defined by the female imaging subcommittee of the ESUR (European Society of Urogenital Radiology) based on the expert consensus of imaging protocols of 11 leading institutions and a critical review of the literature. The results indicated that high field Magnetic Resonance Imaging (MRI) should include at least two T2-weighted sequences in sagittal, axial oblique or coronal oblique orientation (short and long axis of the uterine cervix) of the pelvic content. Axial T1-weighted sequence is useful to detect suspicious pelvic and abdominal lymph nodes, and images from symphysis to the left renal vein are required. The intravenous administration of Gadolinium-chelates is optional but is often required for small lesions (<2 cm) and for follow-up after treatment. Diffusion-weighted sequences are optional but are recommended to help evaluate lymph nodes and to detect a residual lesion after chemoradiotherapy. Expert consensus and literature review lead to an optimized MRI protocol to stage uterine cervical cancer. MRI is the imaging modality of choice for preoperative staging and follow-up in patients with uterine cervical cancer. (orig.)

Balleyguier, Corinne [Radiology Department, Institut Gustave Roussy, Villejuif (France); Sala, E. [Radiology Department, Addenbrooke' s Hospital, Cambridge (United Kingdom); Cunha, T. da [Radiology Department, Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Lisbon (Portugal); Bergman, A. [Department of Radiology, Uppsala University Hospital (Sweden); Brkljacic, B. [Department of Diagnostic and Interventional Radiology, University Hospital ' ' Dubrava' ' , Zagreb (Croatia); Danza, F. [Dipartimento di Bioimmaginie Scienze Radiologiche, Universita Cattolica del S. Cuore, Rome (Italy); Forstner, R. [Zentralroentgeninstitut, Landeskliniken Salzburg, Salzburg (Austria); Hamm, B. [Department of Radiology, Charite Humboldt Universitaet, Berlin (Germany); Kubik-Huch, R. [Institut Radiologie, Kantonsspital Baden, Baden (Switzerland); Lopez, C.; Manfredi, R. [Department of Radiology, ' ' A. Gemelli' ' University Hospital, Rome (Italy); McHugo, J. [Department of Radiology, Birmingham Women' s Hospital, Birmingham (United Kingdom); Oleaga, L. [Radiology Department, Hospital Clinic, Barcelona (Spain); Togashi, K. [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Graduate School of Medicine, Kyoto (Japan); Kinkel, K. [Institut de Radiologie, Clinique des Grangettes, Geneva (Switzerland)

2011-05-15

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Immunotherapy using the streptococcal preparation OK-432 for the treatment of uterine cervical cancer. Cervical Cancer Immunotherapy Study Group.  

UK PubMed Central (United Kingdom)

The efficacy of immunotherapy using a streptococcal preparation, OK-432, was evaluated in each clinical stage of uterine cervical cancer. The 382 eligible patients were stratified by clinical stage and presence/absence of surgery. Within each stratum, patient's were randomly allocated to OK-432 treatment or to control treatment. OK-432 significantly inhibited recurrence in patients with stage II cervical cancer; the recurrence-free interval and survival time were remarkably prolonged in patients with stage II disease who underwent surgery. However, OK-432 did not significantly prolong these parameters in patients with stage III disease. Retrospective analyses revealed that in patients with or without lymph node metastases who underwent surgery, the recurrence-free interval and survival time were significantly prolonged by OK-432 treatment. These results indicate that OK-432 is an effective and useful postoperative immunotherapeutic agent for uterine cervical cancer.

Noda K; Teshima K; Tekeuti K; Hasegawa K; Inoue K; Yamashita K; Sawaragi I; Nakajima T; Takashima E; Ikeuchi M

1989-12-01

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Role of chromosome 3p22.3 in the development of uterine cervical cancer  

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Full Text Available AbstractThe aim of this study was to examine the expression of chromosome 3p22.3 and its role in the development of uterine cervical cancer. The 42 unrelated individuals freshly operated specimens from the cervical region with their corresponding normal or peripheral blood leucocytes (PBL) were collected from the patients. The specimens were undertaken for microdissection procedure. The detection of human papilloma virus (HPV) was done by PCR using the primers MY09 and MY11. The 3p22.3 region appeared to be associated with the development of cervical carcinoma because of significant increase of loss of heterozygosity frequency. The differential deletions in the chromosome 3p22.3 region show that this region plays an important role in the development of the uterine cervical cancer.

Mirunalini Sankaran

2012-01-01

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Cyclic mechanical stretch augments hyaluronan production in cultured human uterine cervical fibroblast cells.  

Science.gov (United States)

Hyaluronan (HA) a glycosaminoglycan with high affinity for water molecules stimulates local inflammatory reactions. Parturition causes a dramatic increase in the amount of HA fragments in the uterine cervix, thereby contributing to a rapid softening as well as opening of the cervical canal, i.e. cervical ripening. The aim of this study was to investigate the possible involvement of cyclic distension caused by labour in the augmentation of HA production during cervical ripening. Immunohistochemistry and/or RT-PCR detected hyaluronan synthase (HAS)1, 2 and 3 in samples of human cervical tissue obtained from pregnant women. Labour-like cyclic mechanical stretch for 24, 36 and 48 h significantly enhanced the secretion of HA, from cultured human uterine cervical fibroblast (CxF) cells, 128.7, 151.4 and 173.2%, respectively, concomitant with a significant augmentation of HAS1 (36, 48 h), HAS2 (24, 36 and 48 h) and HAS3 (48 h) mRNA expression. Cyclic mechanical stretch for 12, 36 and 48 h increased molecular size of the HA secreted from CxF cells. In conclusion, cyclic mechanical stretch of the uterine cervix caused by the presenting part of the fetus in labour may contribute to the increase in the secretion of HA during the process of cervical ripening. PMID:16199413

Takemura, Maki; Itoh, Hiroaki; Sagawa, Norimasa; Yura, Shigeo; Korita, Daizo; Kakui, Kazuyo; Kawamura, Makoto; Hirota, Naoyoshi; Maeda, Hiroshi; Fujii, Shingo

2005-09-30

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Cyclic mechanical stretch augments hyaluronan production in cultured human uterine cervical fibroblast cells.  

UK PubMed Central (United Kingdom)

Hyaluronan (HA) a glycosaminoglycan with high affinity for water molecules stimulates local inflammatory reactions. Parturition causes a dramatic increase in the amount of HA fragments in the uterine cervix, thereby contributing to a rapid softening as well as opening of the cervical canal, i.e. cervical ripening. The aim of this study was to investigate the possible involvement of cyclic distension caused by labour in the augmentation of HA production during cervical ripening. Immunohistochemistry and/or RT-PCR detected hyaluronan synthase (HAS)1, 2 and 3 in samples of human cervical tissue obtained from pregnant women. Labour-like cyclic mechanical stretch for 24, 36 and 48 h significantly enhanced the secretion of HA, from cultured human uterine cervical fibroblast (CxF) cells, 128.7, 151.4 and 173.2%, respectively, concomitant with a significant augmentation of HAS1 (36, 48 h), HAS2 (24, 36 and 48 h) and HAS3 (48 h) mRNA expression. Cyclic mechanical stretch for 12, 36 and 48 h increased molecular size of the HA secreted from CxF cells. In conclusion, cyclic mechanical stretch of the uterine cervix caused by the presenting part of the fetus in labour may contribute to the increase in the secretion of HA during the process of cervical ripening.

Takemura M; Itoh H; Sagawa N; Yura S; Korita D; Kakui K; Kawamura M; Hirota N; Maeda H; Fujii S

2005-09-01

31

Role of FDG-PET in initial workup of uterine cervical cancer  

International Nuclear Information System (INIS)

FDG-PET is widely utilized in gynecologic malignancies. In uterine cervical cancer, although CT, MRI and PET are not included for the most widely used FIGO staging, they may provide useful information additional to clinical stage. We thus investigated the role of FDG-PET in the initial workup of uterine cervical cancer. A total of 85 newly diagnosed uterine cervical cancer patients were included (mean age 50±12yr). Patients previously treated for the cancer were excluded, but conization was an exception. Attenuation corrected whole body PET was interpreted by two nuclear medicine physicians. Suspicious malignant lesions on PET were confirmed by surgical biopsy or other imaging studies. Main tumor masses were detected by FDG-PET in 79 patients (93%). PET detected 15 iliac and 8 paraaortic lymph nodes with increased uptake that was suggested to be metastatic based on other modalities. Among patients who had surgical confirmation of lymph node status, 36 of 40 (90%) patients without lymph node metastasis had concordant PET findings, while PET correctly detected 5 of 16(31%) lymph node metastases. In 8/85 patients (9%), FDG-PET detected distant metastastic lesions which had not been detected by other modalities. Of these patients, treatment modality was changed in 1 and the radiation field was modified in 3 patients. FDG-PET is useful for detecting unidentified metastastic lesions in the initial workup of uterine cervical cancer, and may thus aid in decisions for optional therapeutic strategies

2002-01-01

32

A randomised comparison of two brachytherapy devices for the treatment of uterine cervical carcinoma  

International Nuclear Information System (INIS)

Two brachytherapy applicators commonly used in the treatment of uterine cervical carcinoma, the Henschke shielded and Fletcher-Suit-Declos, were randomly and prospectively compared in vivo in 20 patients. Based on two-dimensional planning and the ICRU-38 bladder and rectal reference points, an advantage for the shielded Henschke applicator was demonstrated.

2005-01-01

33

Metastatic Breast Cancer to the Uterine Cervix Mimicking a Giant Cervical Leiomyoma  

Directory of Open Access Journals (Sweden)

Full Text Available Metastasis to the uterine cervix is a complication of breast cancer that is not commonly known. Detection of cervical metastasis before the diagnosis of the primary tumor is even rarer. The present report describes a case of a 52-year-old woman who had a large cervical tumor appearing as a leiomyoma. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Histopathological examination of the cervical tumor showed patterns characteristic of invasive lobular carcinoma of the breast, leading to the discovery of the primary in the left breast. She subsequently underwent mastectomy, hormone therapy and chemotherapy, and is alive at 7-year follow-up.

MAI HORIKAWA; YUKIKO MORI; SACHI NAGAI; SHIHO TANAKA; SHIGEKO SAITO; TOMOMITSU OKAMOTO

2012-01-01

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Value of intramuscular methotrexate and bilateral uterine artery embolization for treating cervical ectopic pregnancy  

International Nuclear Information System (INIS)

Objective: To assess the clinical value of bilateral uterine artery chemotherapy embolization (UACE) for cervical ectopic pregnancy analyzed. Methods: Clinical records of 40 patients with cervical ectopic pregnancy treated using UACE were retrospectively analyzed. Results: 8 patients with severe active vaginal bleeding after curettage were treated urgently with UACE. The remaining 32 patients were treated with UACE combined with sequential ultrasound-guided curettage. Active vaginal bleeding was stopped after UACE. There was no recurrent hemorrhage with the sequential ultrasound-guided curettage procedure. The ?-HCG levels of all patients were normalized after 1 month. Conclusion: Bilateral uterine artery chemotherapy embolization is valuable as emergency treatment for patients with severe vaginal bleeding from cervical ectopic pregnancy. UACE combined with sequential ultrasound-guided curettage may be more effective. (authors)

2011-01-01

35

Fertility-sparing operation for recurrence of uterine cervical perivascular epithelioid cell tumor  

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Full Text Available Perivascular epithelioid cell tumors (PEComa) are mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelial cells. Although the uterine corpus seems to be one of the most prevalent sites of involvement, PEComa of the uterine cervix are very rare. Only four cervical PEComa cases have been described, and were treated with hysterectomy and radiotherapy. We report a case of a 24-year-old nulli­gravida woman who presented with acute abdominal pain and was diagnosed with a rupture of an ovarian chocolate cyst. Subsequent surgery revealed that the tumor arose in the uterus, and the histological diagnosis was uterine PEComa with low potential malignancy. Recurrent PEComa in the uterine cervix were excised twice, and she remains disease free 12 months after the last operation. To the best of our knowledge, this is the first report of recurrent cervical PEComa with fertility-preserving surgery. Estimating the malignant potential and appropriate surgery are essential for young patients with uterine PEComa.

Eiko Yamamoto; Kazuhiko Ino; Maiko Sakurai; Sachiko Takigawa; Akira Iwase; Fumitaka Kikkawa

2010-01-01

36

Therapeutic effect of intra-arterial chemotherapy with DDP and 5-FU via bilateral uterine arteries for advanced uterine cervical cancer  

International Nuclear Information System (INIS)

Objective: To evaluate the therapeutic effect of intra-arterial chemotherapy with Ddp and 5-Fu via bilateral uterine arteries for advanced uterine cervical cancer. Methods: During the period of Jan. 2006-Jan. 2009, initial intra-arterial chemotherapy by using a combination of Ddp and 5-Fu via bilateral uterine arteries was performed in 72 patients (mean age 42.9 years) with advanced uterine cervical caner. Of 72 patients, stage I b2 cervical cancer was confirmed in 28, stage II a in 12 and stage II b in 32. Pathologically, cervical squamous cell carcinoma was seen in 56 and cervical adenocarcinoma in 16 patients. Ultrasonography and physical examination were conducted both before and after intra-arterial chemotherapy. The therapeutic results,complications,the surgical resection rate and the pathologic findings were observed and statistically analyzed. Results: Fifty-four patients received one treatment course and 18 patients received two treatment courses. The over all response rate was 77.8%. The response rates of patients with I b2, II a and II b cervical cancer were 92.9%, 83.3% and 62.5% respectively, the difference between three groups was statistically significant (P

2010-01-01

37

Survey on the trends in uterine cervical cancer screening in Japanese women: the efficacy of free coupons in the screening.  

UK PubMed Central (United Kingdom)

AIMS: In Japan, cytological examination is performed for uterine cervical cancer screening, but the rate of participation in these programs is low. Between October 1, 2009 and March 31, 2010, free coupons for uterine cervical cancer screening were distributed to Japanese women. The Fukuoka Tuberculosis Prevention Center investigated the trends in uterine cervical cancer screening participation of Japanese women in the 6-month screening program. MATERIAL AND METHODS: The subjects were 1523 women who underwent cervical smear cytology at the Fukuoka Tuberculosis Prevention Center between October 1, 2009 and March 31, 2010. A questionnaire survey based on multiple questions was performed to evaluate awareness about uterine cervical cancer screening for women undergoing screening by cervical smear cytology. RESULTS: The results of the study showed that the rate of women undergoing repeated screening was high among women who underwent screening as part of health checkups that were paid for by the employer according to the recommendations of the Industrial Safety and Health Act. Women who had not undergone the screening previously were motivated to participate after receiving the free coupons. CONCLUSIONS: The distribution of free coupons serves as an initial step towards promoting awareness of preventive measures against uterine cervical cancer.

Kuroki H

2012-01-01

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Opinions and expectations of women in the treatment of cervical and uterine cancer in Spain.  

UK PubMed Central (United Kingdom)

AIM: To know the experiences, needs and expectations of women in the treatment of cervical and uterine cancer in the Andalusian Health Service. METHODS: Focus groups and in-depth interviews with women being treated for cervical-uterine cancer within the Andalusian Health Service. Analysis with Nudist Vivo 1.0 (QSR International Pty Ltd, Doncaster, Victoria, Australia). RESULTS: The needs and expectations detected were: coherence in the promotion strategies and the presence of a proactive approach by health professionals, availability of comprehensive information and understanding, possibility of expressing to health professionals one's doubts and fears, and of participation in decision-making, technical quality, humane treatment and continuity of care and attention to psychosocial aspects. CONCLUSION: The knowledge of women in the treatment of cancer of the cervix and uterus plays a crucial part in improving the delivery of these services.

Rodríguez MA; Suess A; Cerdá JC; Carretero ME; Danet A

2011-11-01

39

Cervical pregnancy treated by uterine artery embolisation combined with office hysteroscopy.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate the safety and efficacy of uterine artery embolisation in conjunction with hysteroscopic resection of trophoblast in the conservative treatment of cervical ectopic pregnancies. STUDY DESIGN: Five women diagnosed with cervical pregnancies at University Hospital of Foggia, Italy, between May 2009 and February 2012 underwent uterine artery embolisation followed by office hysteroscopic resection of trophoblast. Data on operating time, blood loss, blood transfusion, conversion to other techniques, complications related to surgery, change of serum ?-hCG level, hospitalisation days and outcome of the women after discharge were collected. RESULTS: The mean hysteroscopic operative time was 9.8 min, and the blood loss was negligible in all cases. Blood transfusion was not needed for any of the women. None of the women required conversion to other techniques. In all cases the operations were uneventful. The serum ?-hCG level in all the cases declined to normal within 15 days of surgery. The total hospitalisation time was 4 days in all the cases. No vaginal bleeding or other side effects were observed throughout and after the treatment, all women recovered without complications. CONCLUSIONS: Uterine artery embolisation with office hysteroscopic resection is an effective option in treatment of cervical ectopic pregnancy.

Scutiero G; Nappi L; Matteo M; Balzano S; Macarini L; Greco P

2013-01-01

40

Insufficiency fractures in patients treated with pelvic radiotherapy and chemotherapy for uterine and cervical cancer.  

UK PubMed Central (United Kingdom)

Insufficiency fractures are recognised consequences of radiotherapy in gynaecological malignancy with reported incidences between 2.7% and 89%. We aimed to determine the incidence and risk factors for insufficiency fractures in patients receiving radical pelvic radiotherapy for uterine and cervical cancer. A case-note review was undertaken of patients treated between January 2007 and December 2008. Insufficiency fractures were identified from radiographs, computed tomography and magnetic resonance images. Chi-squared and Mann-Whitney tests were performed to determine associations between insufficiency fractures and chemotherapy, steroids and age. A total of 285 patients received pelvic radiotherapy, 137 with uterine and 148 with cervical cancer. Mean age was 59 years. A total of 144 patients received chemotherapy, 101 concurrently and 35 adjuvantly. Bone abnormalities affected 67 patients, 33 had pelvic insufficiency fractures, 12 had multiple fractures and 3 patients developed femoral head avascular necrosis. Use of chemotherapy was not associated with development of fractures (P = 0.949). However, cervical cancer patients had a significantly higher incidence of insufficiency fractures (P = 0.018) and bone pain (P = 0.03) compared with uterine cancer patients. This suggests concurrent chemotherapy may be a significant factor in increasing insufficiency fractures and bone morbidity in these patients and highlights a need for further research to identify, prevent and reduce these long-term complications.

Mehmood Q; Beardwood M; Swindell R; Greenhalgh S; Wareham T; Barraclough L; Livsey J; Davidson SE

2013-07-01

 
 
 
 
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Knowledge, attitudes and practices about uterine cervical cytology by women of a rural population in Colombia  

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Full Text Available Introduction: There is concerned in Latin America due to the little or no impact that have had prevention programs in the reduction of cases of uterine cervical neoplasm. Different aspects should be looked at and analyzed.Objective: To determine the knowledge, practice and attitude of women from themunicipality of Pinillos, Colombia, relating to the use of uterine cervical cytology asdiagnostic techniques of early lesions of uterine cervix that entail uterine cervicalneoplasm.Methods: Descriptive study carried out in Pinillos, Bolívar, Colombia. A survey was filledout by 260 women who had had sexual life.Results: 85.4% of the polled patients know what an uterine cervical cytology is.Practically all the polled women know what the usefulness of cytology is. 99.6%recognizes that cytology is important. 88.5% has done the cytology during her life, witha median of 4 done cytologies.Conclusions: The ignorance, the lack of practice and the bad attitude towards therealization of the cytology are not the main causes of that uterine cervical neoplasm hadnot diminished. Rev.cienc.biomed. 2013;4(1):54-59RESUMENIntroducción: existe preocupación en América Latina por el poco o ningún impacto enreducción de casos, que han tenido los programas de prevención del cáncer del cuellouterino. Diferentes aspectos se deben analizar.Objetivo: determinar el conocimiento, práctica y actitud de las mujeres del municipiode Pinillos, Colombia, sobre el uso de la citología cérvico-uterina como método dediagnóstico de las lesiones tempranas del cuello uterino, que conlleven al cáncer decérvix.Metodología: estudio descriptivo realizado en el municipio de Pinillos, Bolívar, Colombia.Se realizó una encuesta a 260 mujeres que habían tenido vida sexual.Resultados: el 85.4% de las pacientes encuestadas saben que es la citología cérvicouterina.Prácticamente todas las mujeres encuestadas saben para qué sirve la citología.El 99.6% reconoce que realizarse la citología es importante. El 88.5% si se ha realizadola citología durante su vida, con una mediana de 4 citologías realizadas.Conclusiones: el desconocimiento, la falta de práctica y la mala actitud hacia larealización de la citología no es la principal causa que el cáncer de cérvix no hayadisminuido. Rev.cienc.biomed. 2013;4(1):54-59

Barrios-García Lía; Benedetti-Padrón Inés; Alvis-Estrada Luis; Salamanca-Manjarrez Mirlelly

2013-01-01

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Imaging of cervical carcinomas. Imagerie des cancers du col uterin  

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Recently, magnetic resonance imaging (MRI) and transrectal or transvaginal ultrasound (TRUS, TVUS) had an important place in imaging techniques of cervical carcinomas and raise the question of modifying the imaging strategies. For the diagnosis of primitive tumor, those techniques cannot take the place of clinical examination and gross examination. In the assessment of parametrial involvement, TRUS which has better accuracy than clinical examination, and MRI which is considered as the most accurate technique, have an important role to play. In the follow-up and the detection of recurrences, MRI is actually considered as the best imaging technique. The authors, according to recent data in literature and their own experience, present basic concepts of imaging strategies for staging and follow-up of cervical carcinomas.

Soyer, P.; Michel, G.; Masselot, J. (Hopital Louis-Mourier, 92 - Colombes (FR))

1990-12-01

43

Value of Lymphography before and after Radical Hysterectomy in Carcinoma of the Uterine Cervic  

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Radiological demonstration of lymph vessels and lymph nodes may be achieved only by direct lymphography, which is performed by injecting contrast material directly into the lymph vessels, lymph nodes, or occasionally into lymph cysts. Clinical lymphography is performed essentially according to the direct technique of Kinmonth (1952 and 1954). Lymphography has become a routine procedure in patients with carcinoma of the uterine cervix. Thorough assessment of the extent of carcinoma of the uterine cervix is necessary to the intelligent management of any patient with uterine carcinoma. This presentation is to outline the technique of lymphangio-adenography (lymphography), lymphographic finding and diagnostic criteria of the cervical carcinoma, and evaluation of the accuracy of lymphographic diagnosis in cervical carcinoma. A retrospective review of the lymphograms of 145 patients with carcinoma of the uterine cervix was undertaken. All lymphograms were performed at Kang Nam St. Mary's and St. Mary's Hospitals, Catholic Medical College from 1975 to 1982. Of these patients 87 were got radical hysterectomy and lymphographic diagnosis was compared with tissue pathology of the lymph nodes removed, and determined the diagnostic accuracy of lymphography. Lymphography can make a significant contribution in the pretreatment assessment of patients with carcinoma of the uterine cervix. Strick adherence to rigid criteria will yield excellent pathologic correlation in the event of a positive radiographic diagnosis of metastatic carcinoma. Once a positive diagnosis is made, it should influence the management of the cancer patients. The results were as follow: 1. The accuracy of lymphography in diagnosing lymph node matastasis of carcinoma of the uterine cervix was 85.1%, 82.4% in sensitivity and 86.8% in specificity. 2. Metastic lymph nodes were moderately to markedly enlarged and irregular in shape and shown motheaten marginal filling defects in 92.7%. These were ranged from 3mm to 20mm in the greatest diameter. 3. Metastatic lymph nodes showed a tendency to get increased in size, in proportion to the size of marginal filling defect. 4. The size of filling defect of metastatic lymph nodes was not correlated to the clinical stage of carcinoma of the uterine cervix. 5. Lymph node metastasis was confirmed in 6 patients of 10 patients who were got lymphography in 2 to 5 years after radical hysterectomy. 6. Many collateral lymphatics and lymphatic cysts were found out in the lymphography after radical hysterectomy in carcinoma of the uterine cervix.

Kim, Choon Yul; Oh, Yung Ho; Yang, Woo Jin; Bahk, Yong Whee [Catholic Medical College, Seoul (Korea, Republic of)

1983-09-15

44

[Estimation of health-care costs for cervical uterine neoplasm].  

UK PubMed Central (United Kingdom)

OBJECTIVE: to value diagnostic stage and direct costs due to cervical cancer in insured workers and IMSS beneficiaries patients, during first year of treatment. METHODS: 80 records of patients with confirmed diagnosis of cervical cancer during 2000-2003 were analyzed. The study was made under provider public health services perspective, with focus in costs incidence during 2009. RESULTS: 27 (34 %) of total records corresponding to insured worker and 53 (66 %) to beneficiaries. No differences were finding in diagnostic stage. In bout groups stage II was the most common. The cost due medical care adds up to $91,064.00 during first year of treatment in workers. The main costs were identified in sickness absence certification (31 %), image exams (24 %) consulting room (19 %), radiotherapy sessions (10 %) and hospitalization (9 %). CONCLUSIONS: cervical cancer is a frequent disease that affects women in their productive and reproductive age. Frequently their diagnosis is made in advanced stages, which increase medical attention cost. It is convenient to introduce more effective preventive actions, including the workplace.

Sánchez-Román FR; de Jesús Carlos-Rivera F; Guzmán-Caniupan JA; Escudero-de Los Ríos P; Juárez-Pérez CA; Aguilar-Madrid G

2012-01-01

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[Relationship between hedgehog signaling pathway molecules and HPV16 infection in uterine cervical cancers].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To investigate the significance of sonic hedgehog (Shh), indian hedgehog (Ihh), smoothened (Smo) and patched (Ptch) expressions in uterine cervical lesions and their relationships with HPV type 16 infection. METHODS: Totally 183 cases of cervical lesions, including 32 non-neoplastic cervix, 71 cervical intraepithelial neoplasia (28 CINI, 18 CINII, and 25 CINIII) and 80 squamous cell carcinomas (SCC) were selected from the Department of Pathology, Yanbian University Hospital, Yanbian Women Hospital, and Yanbian Tumor Hospital. Shh, Ihh, Ptch and Smo proteins expression were investigated by immunohistochemistry using tissue microarry platform, and the presence of HPV type 16 was detected by PCR method. RESULTS: Immunohistochemical staining showed that the frequencies of Shh, Ihh, Ptch and Smo expression were rare in normal cervical epithelium, but were strongly expressed in cervical cancer and its precursor lesions (CINII/III) (P < 0.01, P < 0.01, P < 0.05, P < 0.05, respectively). In cervical cancer, the expression rate of Shh (95%) was higher than that of CIN (CINI to CINIII) (46.4%, 61.1%, 80.0%, respectively, P < 0.05). HPV16 was positive in 77.5% of SCC. In cervical cancer, the expression of Shh was related with HPV16 infection (P < 0.05), and the expression of Smo was correlated with lymph node metastasis (P < 0.05). CONCLUSIONS: Shh, Ihh, Ptch, and Smo genes may play important roles in the development of cervical cancer. Detection of Hedgehog signaling pathway molecules seems helpful for the early diagnosis of cervical cancer and its precursor lesions, and are potentially therapeutic targets as well.

Xuan YH; Li GL; Jiang HY; Lin ZH

2009-03-01

46

Incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients  

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Full Text Available Abstract Background Renal allograft recipients are reported to have a higher incidence of malignancy than the general population. This single hospital-based study examined the incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients. Methods Among 453 women receiving renal transplantation from January 1990 to December 2008, 5 patients were diagnosed with cervical carcinoma. Medical records of these 5 patients were retrospectively reviewed, and clinicopathologic data were collected and analyzed. Results The incidence of cervical carcinoma in renal transplant recipients was 58.1 out of 100,000 per year, which is 3.5 times higher than in the general Korean population. The mean interval between the time of renal transplantation and the time of cervical carcinoma diagnosis was 80.7 months. After a median follow-up of 96.2 months, there was no recurrence of the disease or death. In 4 patients who were positive from human papillomavirus in situ hybridization (HPV ISH), high or probably high risk HPV DNA was detected in all. Punctate staining of HPV ISH was detected in 3 out of 4 patients. Conclusions Higher incidence of cervical carcinoma is expected in renal transplant recipients, so appropriate surveillance is needed to ensure early detection and treatment of cervical carcinoma.

Park Sung Taek; Song Min Jong; Park Jong Sup; Hur Soo Young; Lee Chung Won

2011-01-01

47

Does a uterine manipulator affect cervical cancer pathology or identification of lymphovascular space involvement?  

UK PubMed Central (United Kingdom)

OBJECTIVE: Uterine manipulators are a useful adjunct for robotic-assisted radical hysterectomy (RARH), but some surgeons avoid their use for fear of altering pathology or interpretation of lymphovascular space involvement (LVSI). We retrospectively compared clinico-pathological data and tumor pathology from patients with cervical cancer operated by laparotomy vs. RARH. METHODS: Charts from cervical cancer patients who underwent radical hysterectomy from January-1997 to June-2010 were reviewed for tumor histology, grade, FIGO stage, lymph node status, LVSI, depth of invasion, and tumor size. A ConMed V-Care® uterine manipulator was used in all robotic cases. H&E stained slides from 20 robotic and 24 open stage IB1 cases with LVSI reported in the original pathology were re-reviewed by a blinded pathologist for analysis of tissue artifacts and LVSI. RESULTS: Two-hundred-thirty-six cases (185 open, 51 robotic) with stages IA2, IB1 and IB2 cervical cancer were reviewed. No significant differences in histology (squamous cell carcinoma, 65% vs. 51%; p=0.1), IB1 lesion size (?2 cm, 62% vs. 61%, p>0.1), LVSI (34% vs. 39%, p>0.1), and depth of stromal invasion (p>0.1) was found between open and robotic groups. Histologic examination of all IB1 cervical carcinomas revealed a higher degree of surface disruption [45% (9/20) vs. 12.6% (3/24), p=0.038] and artifactual "parametrial carryover" [65% (13/20) vs. 29% (7/24), p=0.037] in robotic vs. open groups, respectively, but no significant differences in the rate of LVSI. CONCLUSION: RARH cases that utilized a uterine manipulator did not show any clinico-pathological differences in depth of invasion, LVSI, or parametrial involvement compared to open cases.

Rakowski JA; Tran TA; Ahmad S; James JA; Brudie LA; Pernicone PJ; Radi MJ; Holloway RW

2012-10-01

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Results of Radiotherapy for the Uterine Cervical Cancer  

International Nuclear Information System (INIS)

One hundred fifty-four patients with the carcinoma of the uterine cervix were studied retrospectively to assess the result and impact of treatment at Department of Radiation Oncology, Korea University, Hae-Wha Hospital from Feb 1981 through Dec. 1986. Prior to radiotherapy, the patients were evaluated and staged by recommendation of FIGO including physical examination, pelvic examination, cystoscopy, rectosigmoidoscopy, chest X-ray, IVP, Ba enema. Also, an additional pelvic CT scan was obtained for some of the patients. The patients were treated by radiotherapy alone or adjuvant postoperative irradiation; In case of radiation therapy only, whole pelvic irradiation was given with C0-69 teletherapy unit via AP and PA parallel opposing fields or 4-oblique fields, 180 cGy per day, 5 days per week and intracavitary insertion was performed. Three dimensional quantitative demonstration of tumor volume is also important in planning radiation therapy. Another advantage of CT scan was detection of recurrent tumor after radiation or surgery. Local control rate of tumor according to the size was 91.3% for less than 5 cm in size and 44.6% in tumor over 5 cm (p

1988-01-01

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The opioid neuropeptides in uterine fibroid pseudocapsules: a putative association with cervical integrity in human reproduction.  

UK PubMed Central (United Kingdom)

Abstract The myoma pseudocapsule (MP) is a fibro-vascular network rich of neurotransmitters, as a neurovascular bundle, surrounding fibroid and separating myoma from myometrium. We investigated the distribution of the opioid neuropeptides, as enkephalin (ENK) and oxytocin (OXT), in the nerve fibers within MP and their possible influence in human reproduction in 57 women. An histological and immunofluorescent staining of OXT and ENK was performed on nerve fibers of MP samples from the fundus, corpus and isthmian-cervical regions, with a successive morphometric quantification of OXT and ENK. None of the nerve fibers in the uterine fundus and corpus MPs contained ENK and the nerve fibers in the isthmian-cervical region demonstrated an ENK value of up to 94?±?0.7?CU. A comparatively lower number of OXT-positive nerve fibers were found in the fundal MP (6.3?±?0.8?CU). OXT-positive nerve fibers with OXT were marginally increased in corporal MP (15.0?±?1.4?CU) and were substantially higher in the isthmian-cervical region MP (72.1?±?5.1?CU) (p?uterine corpus, while are highly present into the cervico-isthmic area, with influence on reproductive system and sexual disorders manifesting after surgical procedures on the cervix.

Malvasi A; Cavallotti C; Nicolardi G; Pellegrino M; Vergara D; Greco M; Kosmas I; Mynbaev OA; Kumakiri J; Tinelli A

2013-11-01

50

The opioid neuropeptides in uterine fibroid pseudocapsules: a putative association with cervical integrity in human reproduction.  

UK PubMed Central (United Kingdom)

Abstract The myoma pseudocapsule (MP) is a fibro-vascular network rich of neurotransmitters, as a neurovascular bundle, surrounding fibroid and separating myoma from myometrium. We investigated the distribution of the opioid neuropeptides, as enkephalin (ENK) and oxytocin (OXT), in the nerve fibers within MP and their possible influence in human reproduction in 57 women. An histological and immunofluorescent staining of OXT and ENK was performed on nerve fibers of MP samples from the fundus, corpus and isthmian-cervical regions, with a successive morphometric quantification of OXT and ENK. None of the nerve fibers in the uterine fundus and corpus MPs contained ENK and the nerve fibers in the isthmian-cervical region demonstrated an ENK value of up to 94?±?0.7?CU. A comparatively lower number of OXT-positive nerve fibers were found in the fundal MP (6.3?±?0.8?CU). OXT-positive nerve fibers with OXT were marginally increased in corporal MP (15.0?±?1.4?CU) and were substantially higher in the isthmian-cervical region MP (72.1?±?5.1?CU) (p?uterine corpus, while are highly present into the cervico-isthmic area, with influence on reproductive system and sexual disorders manifesting after surgical procedures on the cervix.

Malvasi A; Cavallotti C; Nicolardi G; Pellegrino M; Vergara D; Greco M; Kosmas I; Mynbaev OA; Kumakiri J; Tinelli A

2013-08-01

51

Relevant incidence of cervical arthritis in patients with erosive seropositive rheumatoid arthritis even today.  

UK PubMed Central (United Kingdom)

OBJECTIVES: This paper aims to investigate adherence to, and outcome of, radiographic screening of patients with rheumatoid arthritis (RA) for cervical involvement, given the availability of state of the art disease-modifying anti-rheumatic drug (DMARD) and biological therapies. METHODS: Cervical screening results and clinical information were obtained from the charts of 395 consecutive patients with rheumatoid arthritis who attended an academic rheumatology outpatient clinic in a 3-month interval. This sample was combined with eight patients who underwent C1-C2 fusion at the Department of Orthopaedic Surgery. RESULTS: Reports on cervical spine x-ray films were not found in the charts of 67 patients (17 %), including 21 (8 %) of the 257 patients with a disease duration of ?5 years. Nevertheless, 17 (7%) of these 257 patients had an increased atlantodental distance. An additional 4 RA patients of the Department of Orthopaedics were added for a total of 21 patients with cervical arthritis, 13 of whom had no cervical symptoms. All 21 patients with cervical arthritis had erosive peripheral arthritis with at least 10 years of disease duration, and were positive for rheumatoid factor. Almost half of these patients were not under adequate DMARD therapy when cervical instability was diagnosed, and none were on biological response modifiers. CONCLUSIONS: Screening for cervical arthritis is still of importance, especially in patients with erosive seropositive disease. In view of the documented incidence, adherence to screening protocols was disappointing.

Hagenow A; Seifert J; Zeissig A; Conrad K; Kleymann A; Aringer M

2013-03-01

52

Role of the purinergic system in patients with cervical intraepithelial neoplasia and uterine cancer.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Cervical cancer remains the second leading cause of death among women. Intraepithelial neoplasias and uterine invasive cancer are frequently associated with disturbances in coagulation and changes in the concentrations of adenine nucleotides. This work intended to analyze changes in extracellular adenine nucleotide hydrolysis and blood platelet aggregation in patients diagnosed for cervical intraepithelial neoplasia in different stages as well as uterine invasive cancer. PATIENTS AND METHODS: NTPDase, E-NPP, 5'-nucleotidase, total ADA and its isoforms (ADA1 and ADA2), as well as the platelet aggregation from patients with different stages of cervical intraepithelial neoplasia (NICs I, NIC II, NIC III) and uterine invasive cancer were verified. RESULTS: Neither ATP hydrolysis nor E-NPP activity was changed by the neoplasia stage. On the other hand, ADP and AMP hydrolysis as well as ADA activity were enhanced in NIC I group. AMP hydrolysis was also increased in the cancer group. ADA 1 was the ADA isoform found in platelets from both control and patient groups. CONCLUSION: Our results showed for the first time that NTPDase, 5'-nucleotidase, E-NPP and ADA are not sensible regarding the grade of neoplasia development, since no significant difference was found between the groups studied. Only ADP hydrolysis and ADA activity showed a significant enhancement in NIC I group related to the other stages possibly as a result of the beginning of the neoplasic transformation. This increase could be reflecting a body's reaction against the probable high adenosine levels. We propose for the first time that the ADA isoform present in platelets is ADA 1.

Maldonado PA; Pimentel VC; Negrini LA; Morsch VM; Schetinger MR

2012-02-01

53

Radiation therapy for pelvic lymph node metastasis from uterine cervical cancer.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To evaluate the efficacy of radiation therapy for pelvic lymph node metastasis from uterine cervical cancer and identify an optimal radiation regimen. METHODS: A total of 111 metastatic pelvic lymph nodes, ranging from 11 to 56 mm (median, 25 mm) on CT/MRI, in 62 patients with uterine cervical cancer were treated initially with curative radiation therapy, with 46 patients receiving concurrent chemotherapy. Total radiation doses ranged from 45-61.2 Gy (median, 50.4 Gy) in 1.8-2 Gy (median, 1.8 Gy) fractions. RESULTS: At a median follow-up of 33 months, 46 of the 62 patients survived. Only 2 irradiated lymph nodes, 24 and 28 mm in diameter, in 1 patient progressed after irradiation alone with 50.4 Gy in 1.8 Gy fractions. All 33 metastatic lymph nodes ?30 mm in diameter were controlled by irradiation at a median dose of 55.8 Gy. The 3-year lymph node-progression free rates were 98.2% in all 62 patients and 98.0% in all 111 metastatic lymph nodes. Except for transient hematologic reactions, 2 patients developed grade ?3 therapy-related toxicities, 1 with an ulcer and the other with perforation of the sigmoid colon. In addition, 2 patients experienced ileus after irradiation. CONCLUSIONS: Radiation therapy effectively controlled pelvic lymph node metastases in patients with uterine cervical cancer, with most nodes <24 mm in diameter controlled by total doses of 50.4 Gy in 1.8 Gy fractions and larger nodes controlled by 55.8 Gy, particularly with concurrent chemotherapy. Higher doses to metastatic lymph nodes may increase intestinal toxicities.

Hata M; Koike I; Miyagi E; Numazaki R; Asai-Sato M; Kasuya T; Kaizu H; Matsui T; Hirahara F; Inoue T

2013-07-01

54

An analysis of prognostic factors in the uterine cervical cancer patients  

Energy Technology Data Exchange (ETDEWEB)

The aim of this study is to analysis of survival and recurrence rates of the uterine cervical carcinoma patients whom received the radiation therapy respectively. The prognostic factors, such as Papanicolaou (Pap) smear, carcinoembriogenic antigen (CEA) and squamous cell carcinoma (SCC) antigen has been studied. From January 1981 to December 1998, eight-hundred twenty-seven uterine cervical cancer patients were treated with radiation therapy. All of the patients were divided into two groups: the radiation therapy only (521 patients) group and the postoperative radiation therapy (326 patients) group. The age, treatment modality, clinical stage, histopathology, recurrence, follow-up Pap smears, CEA and see antigen were used as parameters for the evaluation. The prognostic factors such as survival and recurrence rates were performed with the Kaplan-Meier method and the Cox hazard model, respectively. Median fallow-up was 38.6 months. On the radiation therapy only group, 314 patients (60%) achieved complete response (CR), 47 patients (9%) showed local recurrence (LR), 78 patients (15%) developed distant metastasis (DM). On the postoperative radiation therapy group, showed 276 patients (85%) CR, 8 patients (2%) LR, 37 patients (11%) DM. The 5-year survival and recurrence rates was evaluated for all parameters. The statistically significant factors for the survival rate in univariate analysis were clinical stage (p=0.00001), treatment modality (p=0.0010), recurrence (p=0.0001), Pap smear (p=0.0329), CEA (p=0.0001) and SCC antigen (p=0.0001). This study indicated that after treatment, the follow-up studies of Pap smear, CEA and SCC antigen were significant parameter and prediction factors for the survival and recurrence of the uterine cervical carcinoma.

Yang, Dae Sik; Yoon, Won Sub; Kim, Tae Hyun; Kim, Chul Yong; Choi, Myung Sun [College of Medicine, Korea Univ., Seoul (Korea, Republic of)

2000-12-01

55

An analysis of prognostic factors in the uterine cervical cancer patients  

International Nuclear Information System (INIS)

[en] The aim of this study is to analysis of survival and recurrence rates of the uterine cervical carcinoma patients whom received the radiation therapy respectively. The prognostic factors, such as Papanicolaou (Pap) smear, carcinoembriogenic antigen (CEA) and squamous cell carcinoma (SCC) antigen has been studied. From January 1981 to December 1998, eight-hundred twenty-seven uterine cervical cancer patients were treated with radiation therapy. All of the patients were divided into two groups: the radiation therapy only (521 patients) group and the postoperative radiation therapy (326 patients) group. The age, treatment modality, clinical stage, histopathology, recurrence, follow-up Pap smears, CEA and see antigen were used as parameters for the evaluation. The prognostic factors such as survival and recurrence rates were performed with the Kaplan-Meier method and the Cox hazard model, respectively. Median fallow-up was 38.6 months. On the radiation therapy only group, 314 patients (60%) achieved complete response (CR), 47 patients (9%) showed local recurrence (LR), 78 patients (15%) developed distant metastasis (DM). On the postoperative radiation therapy group, showed 276 patients (85%) CR, 8 patients (2%) LR, 37 patients (11%) DM. The 5-year survival and recurrence rates was evaluated for all parameters. The statistically significant factors for the survival rate in univariate analysis were clinical stage (p=0.00001), treatment modality (p=0.0010), recurrence (p=0.0001), Pap smear (p=0.0329), CEA (p=0.0001) and SCC antigen (p=0.0001). This study indicated that after treatment, the follow-up studies of Pap smear, CEA and SCC antigen were significant parameter and prediction factors for the survival and recurrence of the uterine cervical carcinoma

2000-01-01

56

[A Japanese woman living with cervical uterine cancer: a case study with the social phenomenology approach].  

UK PubMed Central (United Kingdom)

This is the study of the experience of a Japanese woman with cervical uterine cancer carried out in a hospital in the city of Osaka, Japan, using Alfred Schütz's "case study" with the Social Phenomenology approach. The aim was to grasp the meaning of the disease and of hospitalization for this woman, and to try to understand the reasoning around her action. Through the analysis of the data, it was possible to understand that the hospitalization process has to be seen respecting, in addition to individual characteristics, the cultural world, which remits us to human actions and is an important influence on the behavior and attitude regarding the disease and hospitalization.

Chubaci RY; Merighi MA; Yasumori Y

2005-06-01

57

Cervical uterine lesions: an epidemiological and molecular investigation in midwestern Minas Gerais, Brazil.  

Science.gov (United States)

Cervical uterine cancer is the second most frequent form of cancer in the female population and the fourth cause of cancer deaths among Brazilian women. In Divinópolis county, Minas Gerais state, cervical cancer accounted for 6.6% of deaths in 2007. The purpose of this study was to conduct an epidemiological and molecular investigation of samples of pre-neoplastic and neoplastic cervical uterine lesions from patients assisted at public healthcare services in the county. The study was based on clinical-epidemiological descriptions retrieved from cytological examination request forms from 2006 to 2010. For molecular analysis, samples from 95 patients were collected and DNA was extracted using the Chelex 100 method. PCR was performed for detection and typing of HPV 6/11, 16, 18, 31, and 33. Of the 52 168 patients who underwent cytological examination, 625 had pre-neoplastic or neoplastic lesions during the study period. Age distribution was consistent with the literature, with a predominance of patients aged 20-49 years. The microorganism found most frequently was Lactobacillus sp. (65%). Prominent among cellular alterations were cervical intraepithelial neoplasia I (39.7%) and atypical squamous cells of undetermined significance (32%). Molecular analysis revealed 72.6% of positive samples for HPV. HPV 16 (26.3%) was the most frequent type, followed by types 6/11 (7.4%), 18 (5.3%), 33 (2.1%), and 31 (1%). The results provided improved understanding of the association between HPV and cancer in Divinópolis, in addition to providing data that can contribute to the design of measures to prevent and control HPV infection in the county investigated. PMID:23508912

Rocha, Vanessa Regina; Schüffner, Raíssa de Oliveira Aquino; Soares, Isabela Iside Gagliardo; Tibúrcio, Jacqueline Domingues; Ribeiro, Rosy Iara Maciel de Azambuja; Lopes, Débora de Oliveira; dos Santos, Luciana Lara

2013-05-01

58

Cervical uterine lesions: an epidemiological and molecular investigation in midwestern Minas Gerais, Brazil.  

UK PubMed Central (United Kingdom)

Cervical uterine cancer is the second most frequent form of cancer in the female population and the fourth cause of cancer deaths among Brazilian women. In Divinópolis county, Minas Gerais state, cervical cancer accounted for 6.6% of deaths in 2007. The purpose of this study was to conduct an epidemiological and molecular investigation of samples of pre-neoplastic and neoplastic cervical uterine lesions from patients assisted at public healthcare services in the county. The study was based on clinical-epidemiological descriptions retrieved from cytological examination request forms from 2006 to 2010. For molecular analysis, samples from 95 patients were collected and DNA was extracted using the Chelex 100 method. PCR was performed for detection and typing of HPV 6/11, 16, 18, 31, and 33. Of the 52 168 patients who underwent cytological examination, 625 had pre-neoplastic or neoplastic lesions during the study period. Age distribution was consistent with the literature, with a predominance of patients aged 20-49 years. The microorganism found most frequently was Lactobacillus sp. (65%). Prominent among cellular alterations were cervical intraepithelial neoplasia I (39.7%) and atypical squamous cells of undetermined significance (32%). Molecular analysis revealed 72.6% of positive samples for HPV. HPV 16 (26.3%) was the most frequent type, followed by types 6/11 (7.4%), 18 (5.3%), 33 (2.1%), and 31 (1%). The results provided improved understanding of the association between HPV and cancer in Divinópolis, in addition to providing data that can contribute to the design of measures to prevent and control HPV infection in the county investigated.

Rocha VR; Schüffner Rde O; Soares II; Tibúrcio JD; Ribeiro RI; Lopes Dde O; dos Santos LL

2013-05-01

59

Biological properties and radiation responses of the hamster uterine cervical squamous cell carcinoma  

International Nuclear Information System (INIS)

[en] Results of initial studies of the growth characteristics, immunogenicity, histopathology, and radiation response of a uterine cervical squamous cell carcinoma of the Syrian hamster are presented. The cervical carcinoma is a relatively loosely knit, undifferentiated, highly cellular tumor without a recognizable architectural pattern but with a gradation in cellular density decreasing from the perimeter to the center of the tumor. The vascular network corresponds with the histologic features such that radially arranged capillaries join a dilated, tortuous network at the perimeter and with a sparse network in the center of the tumor. Tests of the immunogenicity of the cervical carcinoma by either suppressing the immune mechanism(s) or sensitizing the animal to the tumor indicate that this tumor provides little or no stimulus to the host immunologic system. After radiation exposures ranging from 1000 to 7000 R, tumor volume in persisting tumors shows a pattern of retardation and/or regression followed by regrowth which correlates with exposure. Increasing tumor control occurs with exposures of 3000 R and higher producing a TCD50 120 days of 5800 +- 1100 R. The cause of death in animals containing persisting tumors could be attributed to extensive pulmonary metastases and/or intercurrent infection relative to ulceration and necrosis of the tumor. The major advantages of the use of the Syrian hamster and the cervical carcinoma as a model system and as an interface for the comparison of data from other established tumor models with that from transplantable xenogenic tumor systems is also presented

1979-01-01

60

Clinical Significance of CENP-H Expression in Uterine Cervical Cancer  

Directory of Open Access Journals (Sweden)

Full Text Available Objective This work aims to investigate the expression pattern and clinicopathologic significance of centromere protein H (CENP-H) in uterine cervical cancer (UCC).Methods The level of CENP-H expression in the paraffin sections of 62 UCC cases was determined by the SP immunohistochemical method, with complete clinicopathologic data in all cases. Statistical analysis was conducted to evaluate the prognostic and diagnostic significance of CENP-H using SPSS13.0 software package.Results Immunohistochemical assay showed strong CENP-H expression in 61.29% (38/62) of the paraffin-embedded cervical cancer tissues. Statistical analysis revealed a strong correlation between the CENP-H expression and the clinical classification (P=0.038) of the cervical carcinoma. The expression increased with rise of the stages. The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002) and tumor stage (P=0.001) were independent prognostic markers for the survival of UCC patients. The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001).Conclusions CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC. It might be used as the important diagnostic and prognostic marker for cervical carcinoma patients, especially for those at early stage.

Mei-ying Weng; Lin Li; Shun-jia Hong; Shu-ying Feng

2012-01-01

 
 
 
 
61

[Nucleolar organizer regions in uterine cervical cancer and its precursor epithelial lesions  

UK PubMed Central (United Kingdom)

The number of nucleolar organizer regions was assessed in 115 histological samples of uterine cervical carcinoma or precursor epithelial lesions. Normal endocervical or exocervical epithelial tissues were used as controls. Nucleolar organizer regions were stained with colloidal silver in formalin fixed histological samples and quantified in 100 cells, according to Crocker's method. The mean number of nucleolar organizer regions were 13.7 in infiltrative carcinoma, 9.15 in carcinoma in situ, 9.3 in severe dysplasia, 8.4 in moderate dysplasia, 7.5 in mild dysplasia, 6.4 in condylomas and 3.2 and 2.9 in normal exocervical and endocervical epithelia respectively. There were significant differences in the number of nucleolar organizer regions between normal and abnormal tissues and between the different lesions except between moderate and mild dysplasia and between carcinoma in situ and moderate and severe dysplasia. The highest number of nucleolar organizer lesions was always observed in the basal strata of both normal and abnormal tissues. It is concluded that nucleolar organizer regions are a good index of cellular proliferation in uterine epidermoid cervical carcinoma and its precursor lesions, and have a diagnostic value in infiltrative carcinoma.

Wistuba I; Roa I; Araya JC; Villaseca M; Capurro I; Rojo J

1993-10-01

62

A nuclear DNA study of uterine cervical dysplasia with reference to its prognostic significance.  

UK PubMed Central (United Kingdom)

To further define the nuclear DNA content of uterine cervical dysplasia and its relationship to prognosis and epidemiological features, a retrospective study using Papanicolaou stained cytological specimen and TICAS was undertaken. 1. Dysplasia patients was common among young females who had a background of low age first pregnancy, multiple Gravidity-Parity, the complication of inflammation and the use of hormonal contraceptives and progressed rapidly. It is recommended that a test should be repeated within 2 to 3 months regardless of the severity of the dysplasia and patients should be followed up for at least 2.5 to 3 years. 2. The DNA histograms were classified into 3 types (A,B and C): Type C, which had the stem line in an aneuploidy area, showed more severe dysplastic cases. This may be due to the proliferation rate and significant alternation in the chromosomes and mitoses. Nuclear DNA analysis using TICAS and Papanicolaou stained cytological material could discriminate between the progressive group and the persistent or regressive group. In addition, the mean nuclear area might be the best indicator of prognosis in uterine cervical dysplasia.

Yokosuka K; Sato K; Izutsu T; Kagabu T; Nishiya I; Wied GL

1988-11-01

63

Effect of 5`-DFUR used concurrently in radiotherapy and immunotherapy uterine cervical cancer. Pilot study  

Energy Technology Data Exchange (ETDEWEB)

We conducted a preliminary controlled study in order to evaluate 5`-DFUR dose dependency in efficacy and safety in combination therapy of radiotherapy, 5`-DFUR and SPG for patients with uterine cervical cancer, which was regarded as suitable for cases of radiotherapy. The patients were randomly allocated into group A (5`-DFUR 600 mg/body/day) and group B (5`-DFUR 800 mg/body/day), who underwent radiotherapy with simultaneous administration of 5`-DFUR and SPG (20 mg twice/week or 40 mg/week). Those enrolled were 33 patients in stage II, III or IVa with histologically diagnosed primary squamous cell carcinoma of uterine cervix. CR was shown in 19, PR in 7, NC in 1, and PD in 2 out of 29 efficacy-evaluable cases, so the overall response rate was 89.7% (26/29, 95%CI 72.7%-97.8%). Regarding safety, some side effects were observed in 26 out of 33 safety-evaluable cases (81.3%, 95%CI 63.6%-92.8%), but no serious cases. No significant difference in efficacy and safety was observed between the two treatment groups. These results suggested that the combination therapy of radiotherapy, 5`-DFUR and SPG might be one of the therapies whose effectiveness must be confirmed for advanced squamous cell carcinoma of uterine cervix. To confirm dose dependency of 5`-DFUR, it seems further consideration with more patients is needed. (author)

Hatae, Masayuki [Kagoshima City Hospital (Japan); Noda, Kiichiro; Yajima, Akira [and others

1998-04-01

64

Effect of 5'-DFUR used concurrently in radiotherapy and immunotherapy uterine cervical cancer. Pilot study  

International Nuclear Information System (INIS)

We conducted a preliminary controlled study in order to evaluate 5'-DFUR dose dependency in efficacy and safety in combination therapy of radiotherapy, 5'-DFUR and SPG for patients with uterine cervical cancer, which was regarded as suitable for cases of radiotherapy. The patients were randomly allocated into group A (5'-DFUR 600 mg/body/day) and group B (5'-DFUR 800 mg/body/day), who underwent radiotherapy with simultaneous administration of 5'-DFUR and SPG (20 mg twice/week or 40 mg/week). Those enrolled were 33 patients in stage II, III or IVa with histologically diagnosed primary squamous cell carcinoma of uterine cervix. CR was shown in 19, PR in 7, NC in 1, and PD in 2 out of 29 efficacy-evaluable cases, so the overall response rate was 89.7% (26/29, 95%CI 72.7%-97.8%). Regarding safety, some side effects were observed in 26 out of 33 safety-evaluable cases (81.3%, 95%CI 63.6%-92.8%), but no serious cases. No significant difference in efficacy and safety was observed between the two treatment groups. These results suggested that the combination therapy of radiotherapy, 5'-DFUR and SPG might be one of the therapies whose effectiveness must be confirmed for advanced squamous cell carcinoma of uterine cervix. To confirm dose dependency of 5'-DFUR, it seems further consideration with more patients is needed. (author)

1998-01-01

65

Prognostic value of podoplanin expression in intratumoral stroma and neoplastic cells of uterine cervical carcinomas  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english OBJECTIVE: To investigate the clinicopathological significance of podoplanin expression in the intratumoral stroma and neoplastic cells of early stage uterine cervical cancer. MATERIALS AND METHODS: A total of 143 patients with clinical stage I and IIA uterine cervical carcinomas underwent surgery between 2000 and 2007. Clinicopathological data and slides associated with these cases were retrospectively reviewed. Immunodetection of podoplanin expression in histologic sect (more) ions of tissue microarray blocks was performed using the monoclonal antibody D2-40. RESULTS: Expression of podoplanin was detected in neoplastic cells in 31/143 (21.6%) cases, with 29/31 (93.5%) of these cases diagnosed as squamous carcinoma. For all of the cases examined, the strongest signal for podoplanin expression was observed at the proliferating edge of the tumor nests. The rate of positive podoplanin expression for node-positive cases was lower than that of node-negative (18.9% vs. 22.6%, respectively). Furthermore, the rate of positive podoplanin expression in fatal cases was 10.5% vs. 21.6%, respectively. In 27/143 (18.8%) cases, podoplanin expression was detected in fibroblasts of the intratumoral stroma, and this expression did not correlate with patient age, clinical stage, tumor size, histologic type, depth of infiltration, or vascular involvement. Moreover, expression of podoplanin in intratumoral stroma fibroblasts was only negatively associated with nodal metastasis. A greater number of fatal cases was observed among negative intratumoral stroma fibroblasts (15.5% vs. 3.7%, respectively), although this difference was not significant. CONCLUSIONS: These preliminary results suggest that podoplanin may have a role in host-tumor interactions and, as a result, may represent a favorable prognostic factor for squamous cervical carcinomas.

Carvalho, Filomena M; Zaganelli, Fabricia L; Almeida, Bernardo G L; Goes, Joao Carlos Sampaio; Baracat, Edmund C; Carvalho, Jesus P

2010-01-01

66

Prognostic value of podoplanin expression in intratumoral stroma and neoplastic cells of uterine cervical carcinomas  

Directory of Open Access Journals (Sweden)

Full Text Available OBJECTIVE: To investigate the clinicopathological significance of podoplanin expression in the intratumoral stroma and neoplastic cells of early stage uterine cervical cancer. MATERIALS AND METHODS: A total of 143 patients with clinical stage I and IIA uterine cervical carcinomas underwent surgery between 2000 and 2007. Clinicopathological data and slides associated with these cases were retrospectively reviewed. Immunodetection of podoplanin expression in histologic sections of tissue microarray blocks was performed using the monoclonal antibody D2-40. RESULTS: Expression of podoplanin was detected in neoplastic cells in 31/143 (21.6%) cases, with 29/31 (93.5%) of these cases diagnosed as squamous carcinoma. For all of the cases examined, the strongest signal for podoplanin expression was observed at the proliferating edge of the tumor nests. The rate of positive podoplanin expression for node-positive cases was lower than that of node-negative (18.9% vs. 22.6%, respectively). Furthermore, the rate of positive podoplanin expression in fatal cases was 10.5% vs. 21.6%, respectively. In 27/143 (18.8%) cases, podoplanin expression was detected in fibroblasts of the intratumoral stroma, and this expression did not correlate with patient age, clinical stage, tumor size, histologic type, depth of infiltration, or vascular involvement. Moreover, expression of podoplanin in intratumoral stroma fibroblasts was only negatively associated with nodal metastasis. A greater number of fatal cases was observed among negative intratumoral stroma fibroblasts (15.5% vs. 3.7%, respectively), although this difference was not significant. CONCLUSIONS: These preliminary results suggest that podoplanin may have a role in host-tumor interactions and, as a result, may represent a favorable prognostic factor for squamous cervical carcinomas.

Filomena M Carvalho; Fabricia L Zaganelli; Bernardo G L Almeida; Joao Carlos Sampaio Goes; Edmund C Baracat; Jesus P Carvalho

2010-01-01

67

Protein profiling underscores immunological functions of uterine cervical mucus plug in human pregnancy  

DEFF Research Database (Denmark)

The cervical mucus plug (CMP) differs from the cervical secretions of non-pregnant women, and is the ultimate sealant of the uterine cavity during pregnancy. Although several studies have analyzed biochemical properties of large glycoproteins in the CMP, comprehensive information about its protein composition is yet unavailable. We hypothesized that protein profiling of the CMP could provide key clues to its physiological functions in pregnancy. For this purpose, five CMPs obtained from women in labor at term were analyzed by LC-MS/MS. Out of 291 total proteins identified, 137 were detected in two or more samples, which included S100A8, S100A9, and complement proteins (C3, C4a, C4b, C6, and C8g). Several proteins, which have not been described in the cervical mucus of non-pregnant women or in cervicovaginal fluids, such as CD81 antigen and pregnancy zone protein, were also identified. Gene ontology analysis of identified proteins showed significant enrichment of 28 biological processes such as 'activation of plasma proteins involved in acute inflammatory response' and 'positive regulation of cholesterol esterification'. We report the proteome of CMPs from pregnant women at term for the first time, and the overall findings strongly suggest an important role for the CMP in the maintenance of pregnancy and parturition.

Lee, Deug-Chan; Hassan, Sonia S

2011-01-01

68

Case Report: Uterine Adenocarcinoma Metastasis to the Skull Base and Cervical Spine Presenting with Pathological Fracture and Myelopathy  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: The authors report a rare case of uterine adenocarcinoma metastasis to both the skull base and cervical spine presenting with pathological fracture and myelopathy. Methods: We report the case of a 43-year-old Asian female with widely metastatic uterine adenocarcinoma who over the course of 3 years was diagnosed with a large clival mass and more recently a cervical spine pathological fracture presenting with myelopathy. Results: This patient underwent multiple procedures over a three-year period, including total hysterectomy with tumor debulking, endonasal biopsy of clival mass and most recently cervical corpectomy and fusion. She has received chemotherapy and radiation therapy for treatment of the unresectable clival mass and has done quite well despite having this pathology. Conclusion: This is the first documented case of clival involvement of endometrial adenocarcinoma. Additionally, this is a unique case of spinal metastatic endometrial adenocarcinoma presenting with pathological fracture and myelopathy.

Paul E. Kaloostian; Han Chen; Martina Stippler

2013-01-01

69

Ploidy, cytokinetics, and histology features of aggressive versus less aggressive uterine cervical squamous cell carcinomas  

International Nuclear Information System (INIS)

The authors are investigating the interrelationships of flow cytometric measured ploidy, S-fraction with histology features of uterine cervical squamous cell cancers in an attempt to identify aggressive, high risk tumors and less aggressive tumors. Experimentally, pre-radiotherapy biopsy specimens are being studied using flow ploidy and cell-cycle analysis and microscopic scoring for histology features. The results to date for some 200 patients indicate that there are identifyable aggressive tumors, at high risk for 2 yr local control within each stage of disease and differentiation category (WD, MD, PD). These aggressive tumors usually have high degree DNA abnormalities (triploid or greater), high proliferative activity (%S?20) compared to the less aggressive tumors characterized by diploid/near diploid DNA content, low to moderate %S (2-19, mean 12). Expression of high S-fraction appears to reflect high growth activity or growth potential and characterizes the aggressive tumors.

1985-01-01

70

Combination of irinotecan (CPT-11) and nedaplatin (NDP) for recurrent patients with uterine cervical cancer.  

UK PubMed Central (United Kingdom)

BACKGROUND: The clinical activity of combination of irinotecan (CPT-11) and nedaplatin (NDP) for recurrent patients with uterine cervical cancer was evaluated retrospectively. METHODS: Intravenous CPT-11 was given at 60 mg/m(2) (days 1, 8, 15), followed by NDP 80 mg/m(2) (day 1), every 4 weeks. RESULTS: According to the medical records, 29 cases have received this regimen since 2000. Median age was 57 years (range, 29-80), and performance status (PS) of the patients was 18 cases with PS 0, 10 cases with PS 1, and 1 case with PS 2, respectively. Clinical stage was as follows: 3 cases of stage Ib1, 2 cases of Ib2, 2 cases of IIa, 10 cases of IIb, 8 cases of IIIb, and 4 cases of IVb. There were 27 cases of squamous cell carcinoma and 2 cases of adenocarcinoma. Concerning hematological toxicity of grade 3 or more, neutropenia, leukopenia, and febrile neutropenia were observed in 79.3 %, 96.6 %, and 13.8 % of cases, respectively. For nonhematological toxicity, nausea, anorexia, joint pain, and confusion were observed in only 1 case, respectively, and as a result, in 7 cases chemotherapy was not completed. Among 26 cases with clinically evaluable lesions, there were 7 complete responses, 3 partial responses, 7 stable disease, and 9 progressive disease; the clinical response rate was 38.5 %. Median progression-free survival was 7 months (range, 0-38 months). CONCLUSION: The combination of CPT-11 and NDP seems to be active for patients with recurrent uterine cervical cancer.

Ohara T; Kobayashi Y; Yoshida A; Yoshioka N; Yahagi N; Kondo H; Tozawa A; Kiguchi K; Suzuki N

2012-10-01

71

Cervical digital photography for screening of uterine cervix cancer and its precursor lesions in developing countries.  

UK PubMed Central (United Kingdom)

PURPOSE: This study aims to evaluate and to compare the performance of cervical digital photography (CDP) to the visual inspection with acetic acid (VIA) and visual inspection with Lugol's iodine (VILI) methods for screening the uterine cervix cancer and its precursor lesions in developing countries. METHODS: A cross-sectional study was performed in Brazil. 176 women were evaluated by VIA, VILI, CDP with acetic acid and CDP with Lugol's iodine. Kappa statistic was used to estimate the interobserver and intermethod agreement. Sensitivity, specificity and diagnostic accuracy of the four methods (VIA, VILI, CDP with acetic acid, CDP with Lugol's iodine) was calculated. RESULTS: Interobserver agreement for CDP with acetic acid was K = 0.441 and for CDP with Lugol's iodine was K = 0.533; intermethod agreement of VIA and CDP with acetic acid, K = 0.559; and of VILI and CDP with Lugol's iodine, K = 0.507. Sensitivity and specificity of CDP with acetic acid were 84.00 and 95.83 %, and of CDP with Lugol's iodine were 88.00 and 97.26 %, respectively. The diagnostic accuracy of CDP with acetic acid and CDP with Lugol's iodine was 92.78 and 94.90 %, respectively. CONCLUSION: This was the first study to assess the CDP with Lugol's iodine performance, which had similar performance to the CDP with acetic acid. CDP is considered a promising method for screening the uterine cervix cancer and its precursor lesions in developing countries.

Hillmann Ede C; Dos Reis R; Monego H; Appel M; Hammes LS; Rivoire WA; Capp E

2013-07-01

72

Three-year study of cervical erosions restored with resin and dentin-bonding agent.  

UK PubMed Central (United Kingdom)

Cervical erosions without undercuts and traditional cavity preparation were restored with a light-activated microfilled resin in combination with two different dentin-bonding agents, Gluma and the chemically activated version of Scotchbond. In the Gluma group the final polishing was postponed for at least 1 day; in the Scotchbond group polishing was performed 5 to 15 min after polymerization. The results of the two clinical tests are therefore not comparable. Under these experimental conditions the cumulative 3-year survival rate for the fillings in the two groups were 96% (Gluma) and 66% (Scotchbond). It is concluded that cervical erosions should be restored without undercuts or traditional cavity preparation on the condition that the enamel is acid-etched, polishing of the gingival area is postponed, and an effective dentin-bonding agent is used.

Hansen EK

1989-10-01

73

Factores de riesgo para cáncer de cuello uterino Risk factors for uterine cervical cancer  

Directory of Open Access Journals (Sweden)

Full Text Available El cáncer del cuello uterino es una de las neoplasias malignas de mayor incidencia y mortalidad entre las mujeres de todas partes del mundo, hallazgo que resulta paradójico si se tiene en cuenta que el cuello uterino es de fácil acceso y existen estrategias debidamente probadas que permiten un diagnóstico y tratamiento precoz. En esta revisión se describe detalladamente la epidemiología del cáncer del cuello uterino, en especial los factores de riesgo relacionados con la génesis de la neoplasia y su diagnóstico tardío.Cervical cancer is one of the most frequent neoplasms and one of the most common causes of death among women of reproductive age in the world. These figures are paradoxical if we consider that uterine cervix is easily accessible and that there are proven strategies to early diagnosis and effective treatments. In this paper we provide a detailed review of the epidemiology of cervical cancer, with emphasis on related risk factors associated with carcinogenesis and delayed diagnosis.

Ricardo Ortiz Serrano; Claudia Janeth Uribe Pérez; Luis Alfonso Díaz Martínez; Yuriko Rafael

2004-01-01

74

[Detection and genotyping of human papillomavirus in biopsies of uterine cervical adenocarcinoma].  

UK PubMed Central (United Kingdom)

BACKGROUND: The genotyping of Human Papillomavirus (HPV) will improve knowledge about the local epidemiological association of this virus with adenocarcinoma. AIM: To determine the frequency of HPV genotypes in biopsies of women with uterine cervical adenocarcinoma in a geographic region of Chile. MATERIALS AND METHODS: Forty-one cervical biopsies with a pathological diagnosis of adenocarcinoma, corresponding to all women diagnosed with this cancer between 2002 and 2004, were analyzed. Viral gene Ll was amplified by PCRfor viral detection. HPV genotyping was carried out by a Reverse Line Blot technique. RESULTS: Seventy one percent of biopsies were positive for HPV. The most common genotypes found were HPV 16 (61%), followed by HPV 18 (19.5%). Eighty seven percent of biopsies had a single HPV infection. Three patients had a multiple HPV infection. All of the latter were infected by HPV 16, associated with other three viral genotypes (45, 52 and 66). No low-risk HPV genotypes were found. CONCLUSIONS: In this sample of biopsies, there was a high prevelence of HPV 16 and a low prevalence of HPV 18, which historically has been related to adenocarcinoma. The genotypes found correspond to those described in South America.

Brebi M P; Ili G CG; López M J; García M P; Melo A A; Montenegro H S; Leal R P; Guzmán G P; Roa S JC

2009-03-01

75

[Human papillomavirus genotyping of cervical uterine preneoplastic lesions in a high risk area].  

UK PubMed Central (United Kingdom)

BACKGROUND: The relationship between human papillomavirus (HPV) and uterine cervical cancer (UCC) is widely known and accepted. AIM: To determine the frequency of genotypes of HPV in cervical preneoplastic lesions in a high risk area of UCC. MATERIAL AND METHODS: Using a combination of PCR and Reverse Line Blot technique, 235 formalin fixed paraffin embedded samples, with diagnosis of low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL) were genotyped. RESULTS: HPV was detected in 61.2% of LSIL and 78.1% of HSIL. The main genotypes found were HPV 16, 18, 31, 45, 56 y 58. HPV 16 was the most common in both LSIL (18.1%) and HSIL (36.9%). HPV 16 or 18 were present in 25.1% and 47.1% of the LSIL and HSIL respectively. In both LSIL and HSIL, the predominant viral genotypes were those types classified as with a high oncogenic risk. CONCLUSIONS: HPV genotypes 16, 18, 31, 45, 56 y 58 were the most common in our series. HPV 16 and 18, viral types with high oncogenic risk and included in commercial vaccines, were found in 25.1% and 47.1% of LSIL and HSIL, respectively.

López M J; Ili G CG; Brebi M P; García M P; Capurro V I; Guzmán G P; Suárez P E; Ojeda F JM; Roa S JC

2010-11-01

76

[Assessment of the penetration of culture media in uterine cavity as an effect of cervical lavage before embryo transfer: prospective and observational study of samples obtained in hysterectomy].  

UK PubMed Central (United Kingdom)

Cervical lavage used to remove and cleaning some of the scale elements as well as cervical mucous during embryo transfer has been a regular practice in many reproductive centers worldwide. However, the microenvironment influence using these techniques will or not be detrimental in the embryo development. Under this issue, a prospective study was doing in 16 patients (underwent hysterectomy). A cervical lavage was performed previous to the procedure similar to the embryo's transfer step, subsequently cervical invasion was checking. The age was 36.4 +/- 8.6 years, preoperatory diagnosis was abnormal uterine bleeding (n = 4), myomata (n = 4), adenomiosis (n = 4), endometrial polyp (n = 3) and chronic pelvic pain (n = 1). Uterine weight was 127.5 +/- 55.4 g with a surgical time of 48.8 +/- 12.5 minutes. Medium in the uterine cavity was founded in only one case. We believe that cervical lavage is a secure technique in embryo transfer.

Kably A; Karchmer S; Grosso JM; Quesnel C; Barroso G

2001-10-01

77

Distribution of Uterin Cervical Lesions and Relation Between Age and Parity Rates in the Mardin Province  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: The aim of this study is to evaluate the incidence and distribution of cervical lesions and compare characteristics such as parity and age of the women in Mardin province.Material and Method: Pap smears were drawn from the women screened at Mardin Gynecology and Pediatric Diseases Hospital from 2008 to 2011. All cervicovaginal smears were conventional Pap smear samples evaluated according to the 2001 Bethesda system.Results: There were 3.332 patients in total, whose smears showed no lesions in 3.125 patients. The mean age and number of parities of those patients were 37.34±11.25 and 4.78±3.28. There were 207 smears showing any lesions in cervix; ASC-US, ASC-H, LSIL, HSIL, AGC, squamous cell carcinoma and endocervical adenocarcinoma in 151 (72.94%); 16 (7.72%); 20 (9.66%); 8 (3.86%); 10 (4.83%); 1 (0.48%) and 1 (0.48%) patient, respectively. The mean age and the parities of the patients were 37.63±10.77 years and 4,74±2,92. Although there was no difference between the control and lesion groups, the parity and the age of patients who had ?4 births in both the control and lesion groups were significantly higher than the patients with parities <4 births (p=0.000). There was no difference within the cervical lesion group comparing the ASC-US group with the total of the other lesions.Conclusion: High parity was one of the risk factor for having a lesion in uterine cervix in this population. This study represents an initial attempt to reflect the prevalence and the distribution of cervical lesions and their relation with the parity rates in the eastern regions in Turkey.

Gonca ÖZGÜN1; Gülay AYDO?DU

2013-01-01

78

The study on the immunological effect of Sizofilan combined with radiotherapy in patients with uterine cervical cancer  

International Nuclear Information System (INIS)

To investigate the immunological effect of Sizofilan (SPG) combined with radiotherapy, we evaluated the immunological parameters in 22 patients with uterine cervical cancer. Twelve patients were treated with SPG combined with radiotherapy (SPG group), and the other ten patients with radiotherapy only (control group). During radiotherapy, the numbers of lymphocyte and CD2 positive cell decreased in the SPG and control groups. After radiotherapy, however, its numbers in the SPG group became significantly higher than in the control group (p

1990-01-01

79

Dynamic contrast-enhanced MRI in the diagnosis of uterine cervical cancer  

International Nuclear Information System (INIS)

Objective: To investigate the imaging characteristics of dynamic contrast-enhanced MR imaging (DCE-MRI) in uterine cervical cancer(UCC), and to evaluate the efficacy of DCE-MRI in the diagnosis of UCC. Methods: A total of 39 cases of scratch-pathologically confirmed UCC patients with MRI data were analyzed (one case of carcinoma in sim being negative on MRI was excluded in this study). Time- intensity curves of ROI in pathological regions and adjacent normal regions were obtained and the enhanced rates at different times (16,32,48,64 and 300 s) were calculated. The ARSI% and MRSI% of various groups were compared with t test. Results: All the 39 lesions enhanced at 16 s in DCE, and there was maximum signal contrast between lesions and the surrounding normal tissue in the early arterial phase. ARSI% of tumor (1.97 ± 0.55)% was higher than normal tissue (1.22 ± 0.56 )%, and there was statistically significant difference between them (t=151.000, P3 cm group[(1.70 ± 0.25)% and (2.26 ± 0.18)%] were higher than ?3 cm group [(0.57 ± 0.16)% and (0.73 ± 0.04)%]. ARSI% and MRSI% were higher in the peri-uterine tissue infiltration group [(1.69 ± 0.21)% and (2.26 ± 0.11)%] than that of confined group [(0.63 ± 0.23)% and (0.83 ± 0.03)%] with statistically significant difference (P

2009-01-01

80

Sonoelastography of the uterine cervix as a new diagnostic tool of cervical assessment in pregnant women - preliminary report.  

UK PubMed Central (United Kingdom)

OBJECTIVES: The study aimed at determining whether there exists a correlation between the cervical cohesion parameters assessed in the elastography and the length of the cervix. MATERIAL AND METHODS: Assessment of cervical cohesion parameters with the use of real-time sonoelastography was performed on 59 patients between 28 and 39 weeks of gestation. RESULTS: The analysis showed that there exists a statistically significant (p=0.033) correlation between the cervical length and the elasticity of the front cervical labium (strain ratio A). Correlation coefficient (r) stood at (-) 0.28. CONCLUSIONS: 1. There exists a negative correlation between the condition on the front cervical labium in elastographic imaging and the length of the cervical canal in USG imaging. 2. Elastography of the uterine cervix may be helpful in assessing the risk of premature labour or cervical insufficiency. 3. There is a need to perform a study on a larger group of patients in order to determine whether elastography may find its place among routine obstetric diagnostic methods.

Fuchs T; Woyto? R; Pomorski M; Wiatrowski A; Slejman N; Tomia?owicz M; Florja?ski J; Milnerowicz-Nabzdyk E; Zimmer M

2013-01-01

 
 
 
 
81

High-dose-rate brachytherapy for uterine cervical cancer: the results of different fractionation regimen  

Energy Technology Data Exchange (ETDEWEB)

Although high-dose-rate (HDR) brachytherapy regimens have been practiced with a variety of modalities and various degrees of success, few studies on the subject have been conducted. The purpose of this study was to compare the results of local control and late complication rate according to different HDR brachytherapy fractionation regimens in uterine cervical cancer patients. From November 1992 to March 1998, 224 patients with uterine cervical cancer were treated with external beam irradiation and HDR brachytherapy. In external pelvic radiation therapy, the radiation dose was 45 {approx} 54 Gy (median dose 54 Gy) with daily fraction size 1.8 Gy, five times per week. In HDR brachytherapy, 122 patients (Group A) were treated with three times weekly with 3 Gy to line-A (isodose line of 2 cm radius from source) and 102 patients (Group B) underwent the HDR brachytherapy twice weekly with 4 or 4.5 Gy to line-A after external beam irradiation. Iridium-192 was used as the source of HDR brachytherapy. Late complication was assessed from grade 1 to 5 using the RTOG morbidity grading system. The local control rate (LCR) at 5 years was 80% in group A and 84% in group B ({rho} = 0.4523). In the patients treated with radiation therapy alone, LCR at 5 years was 60.9% in group A and 76.9% in group B ({rho} = 0.2557). In post-operative radiation therapy patients, LCR at 5 years was 92.6% in group A and 91.6% in group B ({rho} 0.8867). The incidence of late complication was 18% (22 patients) and 29.4% (30 patients), of bladder complication was 9.8% (12 patients) and 14.7% (15 patients), and of rectal complication was 9.8% (12 patients) and 21.6% (22 patients), in group A and B, respectively. Lower fraction sized HDR brachytherapy was associated with decrease in late complication ({rho} =0.0405) (rectal complication, {rho} = 0.0147; bladder complication, {rho} =0.115). The same result was observed in postoperative radiation therapy patients ({rho} = 0.0860) and radiation only treated patients ({rho} =0.0370). For radiation only treated patients, a greater number of itemized studies on the proper fraction size of HDR brachytherapy, with consideration for stages and prognostic factors, are required. In postoperative radiation therapy, the fraction size of HDR brachytherapy did not have much effect on local control, yet the incidence of late complication increased with the elevation in fraction size. We suggest that HDR brachytherapy three times weekly with 3 Gy could be an alternative method of therapy.

Yoon, Won Sup; Kim, Tae Hyun; Yang, Dae Sik; Choi, Myung Sun; Kim, Chul Yong [College of Medicine, Korea University, Seoul (Korea, Republic of)

2002-09-15

82

High-dose-rate brachytherapy for uterine cervical cancer: the results of different fractionation regimen  

International Nuclear Information System (INIS)

Although high-dose-rate (HDR) brachytherapy regimens have been practiced with a variety of modalities and various degrees of success, few studies on the subject have been conducted. The purpose of this study was to compare the results of local control and late complication rate according to different HDR brachytherapy fractionation regimens in uterine cervical cancer patients. From November 1992 to March 1998, 224 patients with uterine cervical cancer were treated with external beam irradiation and HDR brachytherapy. In external pelvic radiation therapy, the radiation dose was 45 ? 54 Gy (median dose 54 Gy) with daily fraction size 1.8 Gy, five times per week. In HDR brachytherapy, 122 patients (Group A) were treated with three times weekly with 3 Gy to line-A (isodose line of 2 cm radius from source) and 102 patients (Group B) underwent the HDR brachytherapy twice weekly with 4 or 4.5 Gy to line-A after external beam irradiation. Iridium-192 was used as the source of HDR brachytherapy. Late complication was assessed from grade 1 to 5 using the RTOG morbidity grading system. The local control rate (LCR) at 5 years was 80% in group A and 84% in group B (? = 0.4523). In the patients treated with radiation therapy alone, LCR at 5 years was 60.9% in group A and 76.9% in group B (? = 0.2557). In post-operative radiation therapy patients, LCR at 5 years was 92.6% in group A and 91.6% in group B (? 0.8867). The incidence of late complication was 18% (22 patients) and 29.4% (30 patients), of bladder complication was 9.8% (12 patients) and 14.7% (15 patients), and of rectal complication was 9.8% (12 patients) and 21.6% (22 patients), in group A and B, respectively. Lower fraction sized HDR brachytherapy was associated with decrease in late complication (? =0.0405) (rectal complication, ? = 0.0147; bladder complication, ? =0.115). The same result was observed in postoperative radiation therapy patients (? = 0.0860) and radiation only treated patients (? =0.0370). For radiation only treated patients, a greater number of itemized studies on the proper fraction size of HDR brachytherapy, with consideration for stages and prognostic factors, are required. In postoperative radiation therapy, the fraction size of HDR brachytherapy did not have much effect on local control, yet the incidence of late complication increased with the elevation in fraction size. We suggest that HDR brachytherapy three times weekly with 3 Gy could be an alternative method of therapy.

2002-01-01

83

Vessel-contouring-based pelvic radiotherapy in patients with uterine cervical cancer  

International Nuclear Information System (INIS)

The aim of this study was to assess clinically the adequacy of vessel-contouring-based pelvic radiotherapy with regard to nodal coverage for uterine cervical cancer. Fifty patients with Stages I-III cervical cancer, treated with vessel-contouring-based three-dimensional radiotherapy since August 2002, were entered into the study (median age: 54, 47 received concurrent daily cisplatin). All patients were treated with external beam radiotherapy using a four-field box technique with or without brachytherapy. Pelvic blood vessels were identified and contoured on computed tomography simulation images. A generous margin was set outside these vessels outlined on digitally reconstructed radiograph accounting for normal size lymph nodes, patient's motion and set-up uncertainty. Multi-leaf collimator (MLC) was inserted and adjusted manually. Patterns of recurrence were clinically evaluated. Distance between major vessels and MLC edges varied inter- and intra-individually. Median distance in the mid-iliosacral joint level was 25 mm (left) and 24 mm (right). The maximum and the minimum distances ranged from 25 to 45 mm (median, 32) and 9 to 27 mm (median, 15) for left side and 24 to 41 mm (median, 30) and 7 to 28 mm (median, 15) for right side, respectively. With a median follow-up of 43 months, 10 patients developed recurrence. However, no marginal recurrence was occurred just lateral to the contoured vessels. All three patients who developed regional recurrence had recurred at the internal iliac node or the obturator node medial to contoured vessels. Contoured vessels can be used as surrogate markers for location of the pelvic lymph nodes. (author)

2009-01-01

84

Uterine Junctional Zone Thickness, Cervical Length and Bioelectrical Impedance Analysis of Body Composition in Women with Endometriosis  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: We aimed to evaluate uterine junctional zone thickness, cervical length and bioelectrical impedance analysis of body composition in women with endometriosis.Material and Methods: This is a prospective study conducted in a tertiary teaching hospital. A total of 73 patients were included in the study. Endometriosis was surgically diagnosed in 36 patients (study group). The control group included 37 patients. Main outcome measure(s): Bioelectrical impedance analysis was used to measure body composition. Uterine junctional zone thickness and cervical length were measured by transvaginal ultrasonography.Results: Patients’ characteristics (age, gravida, parity, live baby, age of menarche, lengths of menstrual cycle , percentage of patients with dysmenorrhea, positive family history), body mass index (BMI) (kg/m2), amount of body fat (kg), percentage of body fat were not statistically different between the two groups (p>0.05). The length of menstruation and cervical length were longer in women with endometriosis. Similarly, the inner myometrium was thicker in women with endometriosis than the control group. Conclusion: The relation between endometriosis and demographic features such as age, gravida, parity, gravida, BMI, lengths of the menstrual cycle, age of menarche are controversial. Longer cervical length and thicker inner myometrial layer may be important in the etiopathogenesis of endometriosis.

Selçuk Ayas; Mesut Bayraktar; Ay?e Gürbüz; Akif Alkan; Sadiye Eren

2012-01-01

85

Squamous cell carcinoma antigen in serum for monitoring of head and neck and uterine cervical squamous cell carcinomas after radiotherapy  

International Nuclear Information System (INIS)

Squamous cell carcinoma antigen (SCC-A) in serum was serially measured during follow-up of 96 squamous cell carcinoma patients (75 head and neck cancers and 21 uterine cervical cancers), treated with radiotherapy. In 27 of the patients with head and neck cancer and in 12 of those with cervical cancer SCC-A had also been measured before radiotherapy. In this head and neck carcinoma group, the median level of SCC-A was 1.3 (95% CI: 1.2-1.9) ng/ml before radiotherapy and 1.4 (CI: 1.1-1.5) ng/ml after radiotherapy. In the cervical carcinoma group, the median SCC-A decreased significantly (p

1993-01-01

86

An assessment of interfractional uterine and cervical motion: Implications for radiotherapy target volume definition in gynaecological cancer  

International Nuclear Information System (INIS)

Purpose: To assess interfractional movement of the uterus and cervix in patients with gynaecological cancer to aid selection of the internal margin for radiotherapy target volumes. Methods and materials: Thirty-three patients with gynaecological cancer had an MRI scan performed on two consecutive days. The two sets of T2-weighted axial images were co-registered, and the uterus and cervix outlined on each scan. Points were identified on the anterior uterine body (Point U), posterior cervix (Point C) and upper vagina (Point V). The displacement of each point in the antero-posterior (AP), supero-inferior (SI) and lateral directions between the two scans was measured. The changes in point position and uterine body angle were correlated with bladder volume and rectal diameter. Results: The mean difference (±1SD) in Point U position was 7 mm (±9.0) in the AP direction, 7.1 mm (±6.8) SI and 0.8 mm (±1.3) laterally. Mean Point C displacement was 4.1 mm (±4.4) SI, 2.7 mm (±2.8) AP, 0.3 (±0.8) laterally, and Point V was 2.6 mm (±3.0) AP and 0.3 mm (±1.0) laterally. There was correlation for uterine SI movement in relation to bladder filling, and for cervical and vaginal AP movement in relation to rectal filling. Conclusion: Large movements of the uterus can occur, particularly in the superior-inferior and anterior-posterior directions, but cervical displacement is less marked. Rectal filling may affect cervical position, while bladder filling has more impact on uterine body position, highlighting the need for specific instructions on bladder and rectal filling for treatment. We propose an asymmetrical margin with CTV-PTV expansion of the uterus, cervix and upper vagina of 15 mm AP, 15 mm SI and 7 mm laterally and expansion of the nodal regions and parametria by 7 mm in all directions

2008-01-01

87

Polymorphisms in the genes related to angiogenesis are associated with uterine cervical cancer.  

UK PubMed Central (United Kingdom)

INTRODUCTION: The expression of plasminogen activator inhibitor type 1 (PAI-1), vascular endothelial growth factor (VEGF), and transforming growth factor ?1 (TGF-?1) participates in the angiogenesis of several cancer types. The goal of this study was to investigate polymorphisms in genes related to angiogenesis (PAI-1-675 4G/5G, VEGF C936T, and TGF-?1 G-800A) to evaluate the risk for developing uterine cervical cancer (UCC). METHODS: In a case-control study, 100 healthy subjects and 100 patients with UCC from Mexico were included. We determined the genetic profile of the polymorphic markers, which were evaluated by polymerase chain reaction using a sequence-specific primer. RESULTS: There was no statistical difference in the allele distribution from the intergroup comparisons of PAI-1 675 4G/5G and VEGF C936T data; however, a significant difference was observed within TGF-?1 G-800A. The linkage disequilibrium analysis revealed that PAI-1 -675 4G and TGF-?1 -800A pair-haplotype was in strong linkage disequilibrium with a significantly increased risk (odds ratio, 3.44; 95% confidence interval, 1.66-7.25) to UCC. CONCLUSIONS: The polymorphisms in the genes related to angiogenesis -675 4G/5G PAI-1 and G-800A TGF-?1, segregated solely or combined, might contribute to the increased susceptibility to UCC in a Mexican population.

Ramos-Flores C; Romero-Gutiérrez T; Delgado-Enciso I; Maldonado GE; Plascencia VM; Vazquez-Vuelvas OF; Quintero-Ramos A; Mejía RC; Espinoza-Gomez F; Baltazar-Rodriguez LM; Valdez-Velazquez LL

2013-09-01

88

Immunological evaluation of Sizofiran combined with irradiation in uterine cervical cancer patients  

Energy Technology Data Exchange (ETDEWEB)

Immunological investigation to evaluate the effect of SPG (Sizofiran) combined with irradiation in uterine cervical cancer patients. The study comprised 61 patients among whom 21 were treated with irradiation in combination with surgery and 40 with irradiation alone. All treatments were performed at Kurume University Hospital or affiliate hospitals during the period from May 1989 to April 1992. The patients were randomized to study the effect of polymorph nuclear and lymphocytes counts as well as counts of lymphocytes subsets, and followed for 1 year after treatment. It was found that leukopenia and lymphocytopenia were both more expected in this combined operation and irradiation group, and this effect lasted longer than 1 year. The total lymphocyte count in SPG group was significantly higher and showed an earlier recovery as compared to the control group. This effect was particularly evident in the cytotoxic T lymphocytes. These effects on the immunocompetent cells are mainly attributable to the SPG therapy. The increase of the cytotoxic T lymphocytes was found to be an important factor for survival as evaluated by the Cox Proportional Hazards Model. (author).

Fujiyoshi, Keizou; Tanaka, Hiroshi; Tazaki, Tamikazu (Kurume Univ., Fukuoka (Japan). School of Medicine) (and others)

1994-08-01

89

Immunological evaluation of Sizofiran combined with irradiation in uterine cervical cancer patients  

International Nuclear Information System (INIS)

Immunological investigation to evaluate the effect of SPG (Sizofiran) combined with irradiation in uterine cervical cancer patients. The study comprised 61 patients among whom 21 were treated with irradiation in combination with surgery and 40 with irradiation alone. All treatments were performed at Kurume University Hospital or affiliate hospitals during the period from May 1989 to April 1992. The patients were randomized to study the effect of polymorph nuclear and lymphocytes counts as well as counts of lymphocytes subsets, and followed for 1 year after treatment. It was found that leukopenia and lymphocytopenia were both more expected in this combined operation and irradiation group, and this effect lasted longer than 1 year. The total lymphocyte count in SPG group was significantly higher and showed an earlier recovery as compared to the control group. This effect was particularly evident in the cytotoxic T lymphocytes. These effects on the immunocompetent cells are mainly attributable to the SPG therapy. The increase of the cytotoxic T lymphocytes was found to be an important factor for survival as evaluated by the Cox Proportional Hazards Model. (author)

1994-01-01

90

Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy  

International Nuclear Information System (INIS)

[en] Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of 69 Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

2002-01-01

91

Five-year study of cervical erosions restored with resin and dentin-bonding agent.  

UK PubMed Central (United Kingdom)

The cumulative retention rate of a microfilled resin in non-undercut cervical abrasion/erosion lesions was studied over a 5-yr period. The enamel was etched and the dentin was pretreated with either Gluma (n = 75) or the first marketed version of Scotchbond (n = 30). The cumulative 5-yr retention rate of the Gluma fillings was 90% and that of the Scotchbond fillings 47% (the 95% confidence limits were 83-98% for Gluma fillings and 27-67% for Scotchbond fillings). The retention rate with both bonding agents was significantly higher in the maxillary arch than in the mandibular arch.

Hansen EK

1992-08-01

92

A 3-year evaluation of Gluma and Gluma/Scotchbond for restoration of cervical erosions.  

UK PubMed Central (United Kingdom)

Gluma and Gluma/Scotchbond were used in cervical abrasion/erosion lesions mediating a bond between a resinous restorative material and dentin. The lesions were restored without acid etching of enamel and without use of an intermediary layer of an enamel bonding agent. 142 restorations were placed. The restorations were evaluated clinically using the USPHS-system at the baseline and every half year during a 3-yr period. After 36 months the Gluma and Gluma/Scotchbond restorations showed a 14.3% and 7.4% cumulative loss of retention respectively. No secondary caries was observed during the evaluation period.

van Dijken JW

1990-08-01

93

Expression of mitotic-arrest deficiency 2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer.  

Science.gov (United States)

We previously reported satisfactory therapeutic results when using cisplatin-based cyclic balloon-occluded arterial infusion chemotherapy as neoadjuvant chemotherapy (NAC), which enabled hysterectomy to be performed for patients with locally advanced cervical cancer. Mitotic arrest deficiency 2 (MAD2) is a key component of the mitotic spindle checkpoint pathway. The expression of MAD2 is associated with tumor progression and resistance to chemotherapy. Therefore, the aim of the present study was to examine whether the expression of MAD2 is related to the efficacy of NAC for locally advanced uterine cervical cancer. We reviewed 53 cases of locally advanced uterine cervical cancer (stage IIIa-IIIb; based on the International Federation of Gynecology and Obstetrics criteria). These patients were initially treated at Osaka City University Medical School Hospital, Japan, from 1995 to 2008 and were under 70 years old. Tumor samples were obtained by biopsy prior to NAC. Cases were divided into two groups: one group in which NAC was effective, surgery was possible and radiotherapy was performed (NAC+OP+R group; n=33), and another group in which NAC was ineffective and radiation therapy was performed (NAC+R group; n=20). MAD2 expression was examined in paraffin-embedded sections using the avidin-biotin peroxidase complex method. The results showed that MAD2 expression was significantly higher in the NAC+R group compared to the NAC+OP+R group (P<0.001). There was no significant difference in overall survival between the two groups, although the prognosis for the NAC+OP+R group tended to be slightly better (P=0.064). Taken together, these results suggest that the expression of MAD2 may predict the efficacy of NAC as a treatment for locally advanced uterine cervical cancer. PMID:22969893

Morishita, Masanari; Sumi, Toshiyuki; Nakano, Yusuke; Teramae, Masatomo; Fukuda, Takeshi; Nobeyama, Hiroyuki; Yoshida, Hiroyuki; Matsumoto, Yoshinari; Yasui, Tomoyo; Ishiko, Osamu

2011-12-05

94

Expression of mitotic-arrest deficiency 2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer.  

UK PubMed Central (United Kingdom)

We previously reported satisfactory therapeutic results when using cisplatin-based cyclic balloon-occluded arterial infusion chemotherapy as neoadjuvant chemotherapy (NAC), which enabled hysterectomy to be performed for patients with locally advanced cervical cancer. Mitotic arrest deficiency 2 (MAD2) is a key component of the mitotic spindle checkpoint pathway. The expression of MAD2 is associated with tumor progression and resistance to chemotherapy. Therefore, the aim of the present study was to examine whether the expression of MAD2 is related to the efficacy of NAC for locally advanced uterine cervical cancer. We reviewed 53 cases of locally advanced uterine cervical cancer (stage IIIa-IIIb; based on the International Federation of Gynecology and Obstetrics criteria). These patients were initially treated at Osaka City University Medical School Hospital, Japan, from 1995 to 2008 and were under 70 years old. Tumor samples were obtained by biopsy prior to NAC. Cases were divided into two groups: one group in which NAC was effective, surgery was possible and radiotherapy was performed (NAC+OP+R group; n=33), and another group in which NAC was ineffective and radiation therapy was performed (NAC+R group; n=20). MAD2 expression was examined in paraffin-embedded sections using the avidin-biotin peroxidase complex method. The results showed that MAD2 expression was significantly higher in the NAC+R group compared to the NAC+OP+R group (P<0.001). There was no significant difference in overall survival between the two groups, although the prognosis for the NAC+OP+R group tended to be slightly better (P=0.064). Taken together, these results suggest that the expression of MAD2 may predict the efficacy of NAC as a treatment for locally advanced uterine cervical cancer.

Morishita M; Sumi T; Nakano Y; Teramae M; Fukuda T; Nobeyama H; Yoshida H; Matsumoto Y; Yasui T; Ishiko O

2012-02-01

95

The Prevalence and pattern of HPV-16 immunostaining in uterine cervical carcinomas in Ethiopian women: a pilot study  

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Full Text Available INTRODUCTION: Cancer of the cervix uteri is the second most common cancer among women worldwide. The association of human papillomavirus (HPV) infection with cervical carcinogenesis is well documented. This is a pilot study aiming to studying the prevalence and the pattern of Human Papilloma Virus Type 16 (HPV16) by immunostaining in the tissues of cervical carcinomas of Ethiopian women. METHODS: 20 specimens of uterine cervical carcinomas were studied histopathologically and immunohistochemically for HPV16. RESULTS: Histologically the specimens were classified as: Ten cases were Non Keratinized Squamous cell carcinoma (NKSCC), six cases were Keratinized Squamous Cell Carcinoma (KSCC) and four cases were Adenocarcinoma (ADC). Immunohistochemistry study showed positivity in eleven cases (55%); seven cases (35%) were non-keratinized squamous cell carcinoma; three cases (15%) were keratinized squamous cell carcinoma and one case (5%) belonged to the adenocarcinomas. CONCLUSION: This study reveals a significant detection of HPV in Ethiopian women by the use of advanced techniques such as Immunohistochemistry (IHC). The data of this study suggested that the marked expression of the HPV 16 was in the less differentiated uterine cervix carcinomas

Mona M Rashed; Alemayehu Bekele

2011-01-01

96

Therapeutic Results of Concurrent Chemoradiation in Locally Advanced Uterine Cervical Cancer  

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Purpose : Despite a development for therapeutic machines and advance in modern radiation therapy techniques, locally advanced cervical carcinoma has shown high rate of local failure and poor survival rate. Combination of chemotherapy and radiotherapy demonstrated benefit in improving local control and possibly the overall survival. Our study was performed to evaluate effect of concurrent chemoradiation on locally advanced uterine cervical cancer. Methods and Materials : Twenty six patients with locally advanced stage(FIGO stage IIB with ? 5 cm in diameter, III, IVA) were treated with combination of radiation therapy and concurrent cisplatinum between May of 1988 and September of 1993 at our hospital. Radiation therapy consisted of external irradiation and 1-2 sessions of intracavitary irradiation, Cisplatinum was administered in bolus injection of 25mg/m2 at weekly intervals during the course of external radiation therapy. Results : Of the 26 patients, twenty-five patients were evaluable for estimation of response. Median follow-up period was 25 months with ranges from 3 to 73 months. Stage IIB, III, and IVA were 16, 5,4 patients, respectively. Twenty patients were squamous cell carcinoma. Response was noted in all 25 patients: complete response(CR) in 17/25(68%), partial response(PR) in 8/25(32%). Of the 24 patients except one who died of sepsis at 3 months follow-up, seventeen patients(70.8%) maintained local control in the pelvis: 16/17(94.1%) in CR, 1/17(14.3%) in PR. Fourteen of the 17 patients with CR are alive disease free on the completion of follow-up. Median survival is 28 months for CR and 15 months for PR. Analysis of 5-year survival by stage shows 11/16(59.8) in IIB, 3/5(60.6%) in III, and 1/4(25.0%) in IVA. Overall 5-year survival rate was 55.2%. Ten Patients recurred: 4 at locoregional, 3 in distant metastasis and 3 with locoregional and distant site. Toxicity by addition of cisplatinum was not excessive. Conclusion : Although the result of this study was obtained from small number of patients, it is rather encouraging in view of markedly improved response rate compared with the results of historical group.

1995-01-01

97

Therapeutic Results of Concurrent Chemoradiation in Locally Advanced Uterine Cervical Cancer  

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Purpose : Despite a development for therapeutic machines and advance in modern radiation therapy techniques, locally advanced cervical carcinoma has shown high rate of local failure and poor survival rate. Combination of chemotherapy and radiotherapy demonstrated benefit in improving local control and possibly the overall survival. Our study was performed to evaluate effect of concurrent chemoradiation on locally advanced uterine cervical cancer. Methods and Materials : Twenty six patients with locally advanced stage(FIGO stage IIB with {>=} 5 cm in diameter, III, IVA) were treated with combination of radiation therapy and concurrent cisplatinum between May of 1988 and September of 1993 at our hospital. Radiation therapy consisted of external irradiation and 1-2 sessions of intracavitary irradiation, Cisplatinum was administered in bolus injection of 25mg/m{sup 2} at weekly intervals during the course of external radiation therapy. Results : Of the 26 patients, twenty-five patients were evaluable for estimation of response. Median follow-up period was 25 months with ranges from 3 to 73 months. Stage IIB, III, and IVA were 16, 5,4 patients, respectively. Twenty patients were squamous cell carcinoma. Response was noted in all 25 patients: complete response(CR) in 17/25(68%), partial response(PR) in 8/25(32%). Of the 24 patients except one who died of sepsis at 3 months follow-up, seventeen patients(70.8%) maintained local control in the pelvis: 16/17(94.1%) in CR, 1/17(14.3%) in PR. Fourteen of the 17 patients with CR are alive disease free on the completion of follow-up. Median survival is 28 months for CR and 15 months for PR. Analysis of 5-year survival by stage shows 11/16(59.8) in IIB, 3/5(60.6%) in III, and 1/4(25.0%) in IVA. Overall 5-year survival rate was 55.2%. Ten Patients recurred: 4 at locoregional, 3 in distant metastasis and 3 with locoregional and distant site. Toxicity by addition of cisplatinum was not excessive. Conclusion : Although the result of this study was obtained from small number of patients, it is rather encouraging in view of markedly improved response rate compared with the results of historical group.

Kang, Seung Hee; Suh, Hyun Suk; Yang, Kwang Mo; Lee, Eung Soo; Park, Sung Kwon [Seoul National University College of Medicine, Seoul (Korea, Republic of)

1995-03-15

98

Expression of thymidine phosphorylase as an effect prediction factor for uterine cervical squamous cell carcinoma after radiotherapy: an immunohistochemical study.  

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Prognoses in cases of uterine cervical squamous cell carcinoma treated with radiotherapy were investigated in association with immunohistochemical expression of an angiogenic factor, thymidine phosphorylase (TP). Forty-six cases of uterine cervical squamous cell carcinoma mainly treated with radiotherapy during 1992-2001 at our clinic were studied. All were diagnosed as stages IIB to IVA. Paraffin-embedded biopsy specimens excised before radiotherapy were stained immunohistochemically using anti-TP monoclonal antibody. The extent of staining in both tumor and interstitial cells was graded as (-), (+/-), (+), and (2+). Specimens with TP expression levels of (2+) and (+) were regarded as positively stained and those with TP expression levels of (+/-) and (-) as negatively stained. The efficacy of radiotherapy in both groups was analyzed by the Kaplan-Meier method. With tumor cells, 5-year survival rates for the positive (n= 38) and negative (n= 8) staining groups were 73.9% and 42.9%, respectively; the rate being significantly higher for the TP-positive group (log rank, P= 0.0096). Contrarily, with staining for interstitial cells, the 5-year survival rates for the positive (n= 20) and negative (n= 26) staining groups were 74.1% and 64.6%, respectively, with no significant difference (log rank, P= 0.406). The efficacy of radiotherapy in the group with positive staining of tumor cells was significantly better than in the negative staining group. Immunohistochemical expression of TP in tumor cells is suggested as a useful prognostic factor for uterine cervical squamous cell carcinomas treated with radiotherapy. Choosing therapy for individual cases by referring to factors including TP expression should contribute to an improved prognosis. PMID:16803522

Nakashima, M; Nakano, T; Ametani, Y; Funamoto, H; Uchiyama, A; Miwa, A; Miyata, S; Shoji, M; Kondo, T; Satake, S; Kojima, Y

99

Role of CD24 Protein in Predicting Metastatic Potential of Uterine Cervical Squamous Cell Carcinoma in Patients Treated With Radiotherapy  

International Nuclear Information System (INIS)

[en] Purpose: The protein CD24 is a cell surface protein that appears to function as an adhesion molecule; its expression has been shown to correlate with prognosis in a variety of tumors. The aim of this study was to evaluate the immunoreactivity of uterine cervical squamous cell carcinoma to CD24 and determine whether CD24 is associated with clinical and pathologic parameters, including prognosis. Methods and Materials: The expression of CD24 protein was immunohistochemically studied in 73 cases of uterine cervical squamous cell carcinoma. All patients were treated with definitive radiotherapy alone or with concurrent chemoradiotherapy. Two pathologists independently analyzed the immunostaining; they did not have knowledge of the patient outcomes and evaluated any changes according to the percentage of tumor cells stained as follows: negative, 5% reactive. Results: Positive staining was found in 43 cases (58.9%). The immunoreactivity did not correlate with age, International Federation of Gynecology and Obstetrics stage, lymph node metastasis, or tumor size. For patients who were CD24 negative, the total failure and distant metastasis rates were decreased about 20% compared with the rates for patients who were CD24 positive. On univariate analysis, the 5-year distant metastasis-free survival rate of CD24-negative patients was significantly greater than that of the CD24-positive patients (84.7% vs. 66.7%, respectively, p = 0.0497). The International Federation of Gynecology and Obstetrics stage and CD24 expression were significantly associated with distant metastasis-free survival on multivariate analysis. Conclusions: CD24 expression was a significant independent prognostic factor for distant metastasis-free survival in patients with uterine cervical squamous cell carcinoma. In the future, prospective determination of CD24 expression might aid clinical practice in the selection of the appropriate therapy for individual patients

2007-11-15

100

Predictive role of post-treatment [18F]FDG PET/CT in patients with uterine cervical cancer.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate the efficacy of post-treatment positron emission tomography (PET)/computed tomography (CT) for identification of tumor recurrence, and to determine whether [(18)F]fluorodeoxyglucose (FDG) uptake measured as the maximum standardized uptake value (SUV(max)) has predictive role regarding survival in patients with uterine cervical cancer. METHODS: Medical records from 276 women with uterine cervical cancer who had post-treatment [(18)F]FDG PET/CT performed were retrospectively reviewed. Results of PET/CT scans were compared with histological or clinical examination. RESULTS: Ninety-five (34.4%) of the 276 patients had documented recurrence by either surgical biopsy or clinical and imaging follow-up. Median duration from treatment to PET/CT scan was 24 months (range, 6-307). The overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of post-treatment PET/CT were 94.7%, 87.8%, 80.4%, 97%, and 90.2%, respectively. The PET/CT scan modified both the diagnostic or treatment plan in 67 patients (24.3%). Patients were divided into two groups according to cut-off SUV(max) established on the basis of ROC analysis (<5.25 vs. ?5.25), and there was a significant difference in OS between groups (p=0.001). In addition, the 5-year progression-free survival (PFS) and OS rates of patients with a negative PET/CT scan for recurrence were significantly better than those with a positive PET/CT (98.62% vs. 17.83%, p<0.0001 for PFS, 99.31% vs. 85.38%, p=0.0015 for OS). CONCLUSION: Post-treatment PET/CT scan is a sensitive and accurate surveillance modality, and provides prognostic information in uterine cervical cancer. Furthermore, it may allow individualization of patient care.

Chung HH; Kim JW; Kang KW; Park NH; Song YS; Chung JK; Kang SB

2012-08-01

 
 
 
 
101

[Effect of electro-conization involving the vaginal part of the uterine cervix on cervical mucus parameters].  

Science.gov (United States)

Parameters of cervical mucus and its penetration by spermatozoa were evaluated in 36 women prior to and after conisation of the vaginal part of uterine cervix. After the procedure: complete absence of fecund mucus was revealed in 9 women (25% of cases); in 23 the mucus parameters and the penetration test results were not significantly changed (63.8% of cases) and 4 women became pregnant (11% of cases). The results of studies indicate that in the majority of cases this procedure fails to influence the parameters of mucus, although in a part of cases it may lead to its complete disappearance. PMID:8675073

Hajdasz, P

1995-08-01

102

[Effect of electro-conization involving the vaginal part of the uterine cervix on cervical mucus parameters  

UK PubMed Central (United Kingdom)

Parameters of cervical mucus and its penetration by spermatozoa were evaluated in 36 women prior to and after conisation of the vaginal part of uterine cervix. After the procedure: complete absence of fecund mucus was revealed in 9 women (25% of cases); in 23 the mucus parameters and the penetration test results were not significantly changed (63.8% of cases) and 4 women became pregnant (11% of cases). The results of studies indicate that in the majority of cases this procedure fails to influence the parameters of mucus, although in a part of cases it may lead to its complete disappearance.

Hajdasz P

1995-08-01

103

Role Of Family Planning Practices In The Control And Prevention of Uterine Cervical Cancer- A Multivariate Analysis  

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Full Text Available Research Question: Does acceptance of family planning reduce the risk of uterine cervical cancer? Objective: To study the association between usage of contraceptive methods and cervical carcinogenesis. Study design: Case control study. Settings: Urban Area â€" Hospital Based. Participants: 160 women having different degrees of dysplasia and 173 women having normal pap smears. Statistical Analysis: Multivariate Analysis. Results: None of the three widely prevalent Family Planning practices viz. IUD condoms and tubectomy turned out to be significant in the development of dysplasia, however, age at consummation of marriage before 18 years and illiteracy were significant. Use of IUD offered protection against carcinoma in situ (CIS) and disease of invasive nature. Non- users of condoms were also at risk marginally failing to attain statistical significance.

Sharma S; Juneja A; Sehgal A; Sardana S; Singh V; Murthy N.S; Tuteja R.K

1995-01-01

104

HPV type 18 is more oncopotent than HPV16 in uterine cervical carcinogenesis although HPV16 is the prevalent type in Chennai, India  

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Context: The highest incidence of uterine cervical cancer in India is reported in Chennai. The prevalence and oncopotency are to be considered for the development of vaccines and therapeutic agents. Aims: The aim of the present study is to analyze the prevalence and oncopotency of h...

Berlin Grace V

105

Expression of keratinocyte growth factor receptor (KGFR/FGFR2 IIIb) in human uterine cervical cancer.  

Science.gov (United States)

Keratinocyte growth factor receptor (KGFR), also known as FGFR2 IIIb, is a splice variant of FGFR-2. KGFR is expressed in many types of epithelial cell and is activated with four known ligands [FGF-1, FGF-3, FGF-7 (also known as KGF) and FGF-10] that are predominantly synthesized by mesenchymal cells. KGFR is highly expressed in the late-proliferative phase of a normal endometrium and in endometrial adenocarcinoma. In the present study, we attempted to determine the expression and localization of KGFR in human cervical cancer cell lines and cervical cancer tissues. The KGFR protein was detected in CaSki and HeLa cells, but not in ME-180 cells of cervical cancer cell lines. In non-cancer cervical tissues, KGFR immunoreactivity was weakly expressed in the surface of squamous epithelial cells and vascular smooth muscle cells. Immunohistochemically, the KGFR protein was detected in squamous cell carcinoma in 36 of 42 (86%) cervical cancer patients. In cervical cancer tissues, KGFR was detected in 17 of 18 (94%) of patients with the keratinizing type and 19 of 24 (79%) of patients with the non-keratinizing type of cervical cancer. Furthermore, KGFR was prominently localized in proliferating reserve cells and squamous metaplastic reserve cells adjacent to cancer cells. In contrast, KGFR was not detected in cervical ductal cells in cancer or non-cancer cervical tissues. These findings may indicate that KGFR mediates the growth and differentiation of reserve cells and squamous cell carcinoma in the cervix. PMID:15069536

Kurban, Gulnar; Ishiwata, Toshiyuki; Kudo, Mitsuhiro; Yokoyama, Munehiro; Sugisaki, Yuichi; Naito, Zenya

2004-05-01

106

A Case of Cervical Pregnancy Following Uterine Curettage: The Most Advanced in Iranian Population  

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A case of cervical ectopic pregnancy in a 37 years old woman with history of two previous cesarean sections and one dilatation/curettage. The case was the advanced cervical pregnancy reported in Iran, which diagnosed in 12 week of gestation by MRI and finally treated by hysterectomy.

Monir Ashouri; Ashraf-Sadat Mousavi; Zahra Najmi; Mahjabin Marashi

107

A Case of Cervical Pregnancy Following Uterine Curettage: The Most Advanced in Iranian Population  

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Full Text Available A case of cervical ectopic pregnancy in a 37 years old woman with history of two previous cesarean sections and one dilatation/curettage. The case was the advanced cervical pregnancy reported in Iran, which diagnosed in 12 week of gestation by MRI and finally treated by hysterectomy.

Monir Ashouri; Ashraf-Sadat Mousavi; Zahra Najmi; Mahjabin Marashi

2011-01-01

108

Cerebellar metastases in patients with uterine cervical cancer. Two cases reports and review of the literature; Metastases cerebelleuses chez des patientes atteintes d'un cancer du col uterin. A propos de deux cas et revue de la litterature  

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Brain metastases from cervical cancer are extremely rare. We report on two patients who developed cerebellar metastases following uterine cervical cancer. The interval between diagnosis of the primary cancer and diagnosis of brain metastasis was 8 months. The main complaint was symptoms of increased intracranial pressure and cerebellar syndrome. Surgical excision of the brain lesion followed by radiation therapy was performed in the first case. The second patient received palliative radiation therapy. The first patient died 8 months after diagnosis. The second patient is alive 2 months after diagnosis. (authors)

El Omari-Alaoui, H.; Gaye, P.M.; Kebdani, T.; El Ghazi, E.; Benjaafar, N.; Mansouri, A.; Errihani, H.; Kettani, F.; El Ouahabi, A.; El Gueddari, B.K. [Institut National d' Oncologie, Service de Radiotherapie, Rabat (Morocco)

2003-10-01

109

The study on the immunological effect of Sizofilan combined with radiotherapy in patients with uterine cervical cancer  

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To investigate the immunological effect of Sizofilan (SPG) combined with radiotherapy, we evaluated the immunological parameters in 22 patients with uterine cervical cancer. Twelve patients were treated with SPG combined with radiotherapy (SPG group), and the other ten patients with radiotherapy only (control group). During radiotherapy, the numbers of lymphocyte and CD2 positive cell decreased in the SPG and control groups. After radiotherapy, however, its numbers in the SPG group became significantly higher than in the control group (p<0.05). The number of CD3 positive cell also presented a tendency to increase after radiotherapy in the SPG group. As for CD20 positive cell, its numbers were kept unchanged after radiotherapy in both groups, and no significant difference was observed between them. NK cell activity decreased during radiotherapy in both groups. After radiotherapy, its activity in the SPG group recovered to its pre-value and became significantly higher than that in the control group (p<0.05). SPG did not have any prominent effect on CD4/CD8 ratio. The adverse effect of SPG to liver or kidney function was not observed in our patients. The SCC level in the SPG group decreased rapidly by radiotherapy as well as that in the control group, and no significant difference was observed in SCC levels between them. So it was suggested that SPG did not suppress the cytocidal effect of radiation to cancer cells. Based on these findings, it was concluded that SPG prompted the recovery of not only lymphocyte, especially T cell, but also NK cell activity. These immunological findings presented a usefulness of clinical application of SPG to radiotherapy in patients with uterine cervical cancer. (author).

Sekiguchi, Isao; Suzuki, Mitsuaki; Izumi, Akio; Aida, Ichiro; Tamada, Taro (Jichi Medical School, Minamikawachi, Tochigi (Japan))

1990-11-01

110

Primary cervical and uterine corpus lymphoma; a case report and literature review.  

Science.gov (United States)

Primary lymphoma of the uterine corpus and cervix is rare. We present a case of primary non-Hodgkin follicular lymphoma isolated to uterine corpus and parametria with focal spread to ovaries and fallopian tubes, incidentally found on the background of endometrial malignancy. A summary of the published cases focusing on the presentation and prognosis as well as a review of current management are discussed. The rising incidence of extra-nodal lymphoma and recent changes in classification and therapeutic approach, require clinical vigilance. In the absence of prospective studies assessing the value of the available therapeutic options, data from retrospective series and scattered case reports are presented in this review. PMID:23641308

Anagnostopoulos, Antonios; Mouzakiti, Niki; Ruthven, Stuart; Herod, Jonathan; Kotsyfakis, Michail

2013-04-12

111

Primary cervical and uterine corpus lymphoma; a case report and literature review.  

UK PubMed Central (United Kingdom)

Primary lymphoma of the uterine corpus and cervix is rare. We present a case of primary non-Hodgkin follicular lymphoma isolated to uterine corpus and parametria with focal spread to ovaries and fallopian tubes, incidentally found on the background of endometrial malignancy. A summary of the published cases focusing on the presentation and prognosis as well as a review of current management are discussed. The rising incidence of extra-nodal lymphoma and recent changes in classification and therapeutic approach, require clinical vigilance. In the absence of prospective studies assessing the value of the available therapeutic options, data from retrospective series and scattered case reports are presented in this review.

Anagnostopoulos A; Mouzakiti N; Ruthven S; Herod J; Kotsyfakis M

2013-01-01

112

Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma.  

UK PubMed Central (United Kingdom)

The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of cervical carcinoma, we investigated the DNA promoter hypermethylation profiles in CA and CSCC. In addition, we investigated whether DNA hypermethylation patterns might be used for the molecular diagnosis of CA and endometrial adenocarcinoma (EA). Using the bisulfite-modification technique and methylation-specific PCR, we examined the aberrant promoter hypermethylation patterns of 9 tumor suppressor genes (APC, DAPK, CDH1, HLTF, hMLH1, p16, RASSF1A, THBS1 and TIMP3) in 62 CSCCs, 30 CAs and 21 EAs. After Bonferroni correction adjustment (statistically significant at p < 0.0055), we found that the aberrant hypermethylations of CDH1 and DAPK were more frequent in CSCCs than in CAs (80.6% vs. 43.3%, p = 0.001; 77.4% vs. 46.7%, p = 0.005), whereas HLTF and TIMP3 were more frequently methylated in CAs (3.2% vs. 43.3%, p < 0.001; 8.1% vs. 53.3%, p = 0.001). The hypermethylations of RASSF1A and APC were more frequent in CAs than in CSCCs, but this was not significant (9.7% vs. 33.3%, p = 0.008; and 14.5% vs. 40.0%, respectively, p = 0.009). In addition, RASSF1A hypermethylation was significantly more frequent in EAs than in CAs (81.0% vs. 33.3%, p = 0.001). In conclusion, the existence of these unique methylation patterns in these cancers suggests that their tumorigenesis may involve different epigenetic mechanisms.

Kang S; Kim JW; Kang GH; Lee S; Park NH; Song YS; Park SY; Kang SB; Lee HP

2006-05-01

113

Analysis of the complications after radical hysterectomy for stage IB, IIA and IIB uterine cervical cancer patients.  

UK PubMed Central (United Kingdom)

AIM: This study was undertaken to assess whether radical hysterectomy and pelvic lymphadenectomy could be carried out within acceptable complications in uterine cervical cancer patients. MATERIAL & METHODS: One hundred and forty-six patients of the International Federation of Gynecology and Obstetrics stage IB, IIA and IIB cervical cancer treated by radical hysterectomy or combined with postoperative radiation therapy were enrolled in this study. The study population was 41 women over the age of 60 and 105 women under the age of 59. Complications after the treatment of all patients were examined. RESULTS: The complications were significantly high with the patients over the age of 60 (53.7%) in comparison with the patients under the age of 59 (24.8%). Especially, the cases combined with radiation therapy had higher complication rate. The most commonly recorded complications were lymphedema (13.7%) and small bowel obstruction (8.2%). CONCLUSION: We conclude that the complications influenced on the quality of life were more frequent in patients over the age of 60.

Kashima K; Yahata T; Fujita K; Tanaka K

2010-06-01

114

[Optical coherence tomography: preliminary results with a new noninvasive technique for evaluating uterine cervical tissue and vulvar epithelium].  

UK PubMed Central (United Kingdom)

AIM: Optical coherence tomography (OCT) is a noninvasive diagnostic imaging technique that captures high-definition real-time images at near-microscopic resolution (1-2 mm below the surface) of biological tissue morphology. The aim of this study was to define the characteristics of uterine cervical and vulvar pathologies by means of OCT and to compare OCT findings versus histopathological features. MATERIALS AND METHODS: This prospective single-center study was approved by the regional ethical committee. The OCT scans were performed in women with suspected cervical intraepithelial neoplasia (CIN) or vulvar intraepithelial neoplasia (VIN). The suspicious lesions were identified using colposcopy, visualized by OCT, and then biopsied. The OCT scans were evaluated by two independent examiners. The results were then compared with the histopathological findings. The sensitivity and specificity of OCT were calculated. RESULTS: Overall, 50 of the 54 CIN and 2 carcinomas confirmed on histology were correctly diagnosed with OCT, yielding a sensitivity of 93%; specificity was 33%, with 8 false positives and 4 true negatives. In 10 patients with suspected VIN, 19 OCT images were compared with the corresponding biopsies. Three states of tissue structure could be distinguished, with typical features of normal tissue and tissue altered by neoplastic transformation. CONCLUSION: OCT is a noninvasive, fast and simple technique to obtain real-time information on tissue microstructure. Further study is needed to assess its use in routine diagnostic imaging; however, these preliminary results indicate its high sensitivity.

Gallwas J; Chiapponi C; Turk L; Ochsenkuehn R; Friese K; Dannecker C

2010-10-01

115

Long-term outcomes of intracavitary hyperthermia in combination with radiotherapy for locally advanced uterine cervical cancer  

International Nuclear Information System (INIS)

Objective: To evaluate the long-term clinical efficacy and toxicities of combined intracavitary hyperthermia and radiotherapy for locally advanced uterine cervical cancer. Methods: 310 patients with locally advanced uterine cervical cancer were assigned into intracavitary hyperthermia + radiotherapy group(TRT, 181 patients) and external-beam radiotherapy + traditional intracavitary radiation group (RT,129 patients). The external-beam radiotherapy were given with 60Co ?-ray or 6-8 MV X-ray in traditional fractionation. In TRT group, radiotherapy was 40 Gy using the anterior-posterior pelvic fields and additional 20-25 Gy using the lateral fields. Hyperthermia was delivered by the 915 MHz microwave hyperthermia device within 15-60 min after external radiotherapy for 10-12 times(40 min each time, 1-2 times per week). The temperature of tumor surface was 46-47 degree C. In the RT group, the external-beam radiotherapy of 40 Gy was delivered using the anterior-posterior pelvic fields. The intracavity radiotherapy of radium was delivered before 1989, with 50 mg radium in the vagina and 30 mg in uterine cavity for 24 hours, weekly for 3 times to a total dose of 7200 mg?h. After 1989, intracavity radiotherapy of 192Ir was delivered to a total dose of 30-36 Gy to point A in 5-6 Gy fractions, 2 fractions per week. Results: The 5-year survival of patients in TRT group and RT group was 67.4% versus 52.1% for stage II disease (?2=7.55, P=0.006), and 60.0% versus 32.3% for stage III (?2=7.06, P=0.007). The 10-year survival was 46.5% versus 42.6% for stage II (?2=3.90, P=0.058), and 43.7% versus 20.6% for stage III (?2=17.28, P=0.000). Cox regression analysis showed that the tumor stage(P=0.023) and intracavitary hyperthermia (P=0.019) were prognostic factors. According to the RTOG criteria, the rate of mild to moderate late side effects of rectum and bladder in TRT and RT group was 17.7% and 33.1%, respectively (?2=9.18, P=0.002). Rectovaginal fistula was developed in 5 patients (3.9%) in RT group and 1 patient (0.6%) in TRT group (?2= 4.38,P=0.036). Conclusions: The long-term survival of patients with stage III uterine cervical cancer is better of TRT group than RT group. The TRT is well tolerated and the late toxicity rate is obviously low. it is necessary to carry out large randomized clinical trials to confirm these outcomes. (authors)

2008-01-01

116

Local lymphocytes and nitric oxide synthase in the uterine cervical stroma of patients with grade III cervical intraepithelial neoplasia  

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Full Text Available OBJECTIVES: Precancerous and cancerous cells can trigger an immune response that may limit tumor development and can be used as a prognostic marker. The aims of the present study were to quantify the presence of B and T lymphocytes, macrophages and cells expressing inducible nitric oxide synthase (iNOS) in the cervical stroma of women with grade III cervical intraepithelial neoplasia (CIN III) or in the intratumoral and peritumoral tissue of women with stage I invasive carcinoma. METHODS: Cervical tissue specimens were obtained from 60 women (20 each from control tissues, CIN III and invasive carcinomas). The average ages in the control, CIN III and invasive groups were 43.9 (± 4.3), 35.5 (± 9.5), and 50 (± 11.2) years, respectively. The specimens were immunohistochemically labeled with antibodies to identify T lymphocytes (CD3), cytotoxic lymphocytes (CD8), B lymphocytes (CD20), macrophages (CD68) and iNOS. We evaluated the markers in the stroma above the squamocolumnar junction (control), at the intraepithelial lesion (CIN cases), and in the nfiltrating tumor. Two independent observers performed the immunohistochemical analysis. RESULTS: T lymphocytes, B lymphocytes, macrophages and iNOS were present more frequently (P<0.05) in the stroma of peritumoral invasive tumors compared to the controls and intratumoral invasive cancer samples. CD3+ and CD20+ lymphocytes were present more frequently in CIN III patients compared to samples from patients with intratumoral invasive cancer (P<0.05). CONCLUSION: High numbers of T and B lymphocytes, macrophages and iNOS-expressing cells in the peritumoral stroma of the invasive tumors were observed. Cell migration appeared to be proportional to the progression of the lesion.

Cléber Sergio da Silva; Marcia Antoniazi Michelin; Renata Margarida Etchebehere; Sheila Jorge Adad; Eddie Fernando Candido Murta

2010-01-01

117

Colposcopic, cytologic and isotopic methods in early diagnosis of uterine cervical carcinoma  

International Nuclear Information System (INIS)

The authors examined 112 women with changes in the uterine cervix using colposcopic, cytologic and isotopic methods. Comparing the obtained data of each method on the one side, and taking histological results as a basis for comparison of the exactness, on the other hand, they come to the following conclusions: (1) Carcinoma in development is diagnosed by means of colposcopy more surely in comparison with the remaining methods. (2) For establishing the earliest form of cancerous disease of the uterine cervix the cytological method gives positive data than the remaining two methods. (3) The isotopic method, based on the level of phosphorus 32 accumulation, gives less exact information in comparison with the colposcopic and cytologic methods. (4) The complex application of the three methods gives a possibility for correction of the mistakes of each method, used singly. (author)

1977-01-01

118

A case of radiation-induced cutaneous angiosarcoma 15 years after simultaneously occurring uterine cervical and gastric cancers discovered by autopsy  

International Nuclear Information System (INIS)

A case of cutaneous angiosarcoma in the skin on the left hip previously irradiated for cervical uterine squamous cell carcinoma is discovered by autopsy. The patient, a 79-year-old woman, at age 64 had been then underwent radiotherapy for the cervical uterine carcinoma. A total dose of 50 Gy was administrated. At 79 years of age, she noticed multiple purple black nodular skin lesions on the left hip and thigh. She was hospitalized for 8 days, but her general condition rapidly deteriorated and she died. An autopsy revealed that the skin lesion was composed of atypical polygonal cell proliferation forming irregularly anastomosing vascularity, together with hemorrhage and necrosis. The tumor cells were positive for both CD34 and factor 8-related antigens. The final diagnosis was angiosarcoma. (author)

2005-01-01

119

Immunotherapy using the streptococcal preparation OK-432 for the treatment of uterine cervical cancer. Cervical Cancer Immunotherapy Study Group.  

UK PubMed Central (United Kingdom)

The effectiveness of immunotherapy using a streptococcal preparation, OK-432, was evaluated for cervical cancer. The 382 eligible patients were stratified by presence/absence of surgical operation and clinical stage, and then, in each stratum, were randomly divided into two groups: an OK-432 treatment group and a control treatment group. The 3-year recurrence-free rates of 221 patients in the OK-432 group and 161 patients in the control group were 71.9% and 58.6%, respectively. The intergroup difference was statistically significant (P less than 0.05). Delayed skin reactions to phytohemagglutinin (PHA) and Su-polysaccharide extracted from Streptococcus pyogenes Su-strain (Su-PS) and peripheral lymphocyte counts were reduced within two months after the initiation of therapy in both groups. The observed immunological changes were apparently reversed by 3 months after the start of the therapy in the OK-432 group, but this took at least one year in the control group, with significant intergroup differences at 6 and 12 months of the therapy (P less than 0.01). These results indicate that OK-432 can be considered as one of the most effective and useful immunotherapeutic agents for cervical cancer.

1987-11-01

120

Downregulation of tumor suppressor gene PML in uterine cervical carcinogenesis: impact of human papillomavirus infection (HPV).  

UK PubMed Central (United Kingdom)

OBJECTIVES: Cervical cancer is a leading gynecological cancer in Indian women and is caused due to infection with high risk human pappilloma virus (HR-HPV) 16 and 18. It has been well documented that PML (promyelocytic leukemia) enhances viral infectivity and plays a crucial role in antiviral response mechanisms. The aim of the present study was to evaluate the role of PML gene with context to HPV infection in cervical carcinogenesis. METHODS: The expression pattern of PML was analyzed by western blotting and immunohistochemistry in a total of 170 fresh surgically resected cervical tissue specimens comprising precancer (n=12), cancer (n=118) and normal controls (n=40) recruited from PGIMER, Chandigarh, India. HPV status was analyzed by L1 consensus PCR followed by type specific PCR for HR-HPV types 16 and 18 and low risk types 6 and 11. RESULTS: A significant downregulation of PML protein was observed in the majority of cervical cancer and precancer cases 68% (89/130) compared to normal controls. The loss of expression pattern of PML gene was significantly increased with severity of disease both clinically and pathologically (p<0.001). HPV infection was detected in the majority of cancer cases 96% (113/118) and in 83% (10/12) of precancer lesions whereas no infection could be detected in normal controls. Interestingly, all the 68% (89/130) cervical cancer cases that showed downregulation of PML were HPV infected (p=0.0001). CONCLUSION: Taken together, these observations suggest that the downregulation of PML gene and its synergism with HPV infection may play an important role and may serve as a new marker for early diagnosis and therapeutic intervention for cervical carcinogenesis.

Singh N; Sobti RC; Suri V; Nijhawan R; Sharma S; Das BC; Bharadwaj M; Hussain S

2013-03-01

 
 
 
 
121

Limitation of rectal examination, CT, and MRI as a tool for diagnosing the invasion to cardinal ligaments in the uterine cervical cancers  

International Nuclear Information System (INIS)

[en] The clinical methods such as pelvic (rectal) examination, CT, and MRI have been commonly used in order to detect invasion to the cardinal ligaments (CL) for determination of preoperative staging in the uterine cervical cacner. We examined the accuracy of their clinical means as for diagnosis of invasion to the CL, compared with histological findings of surgical specimens. One hundred twenty five patients with the uterine cervical cancer stage Ib or stage II who underwent a radical hysterectomy between 1987 and 1999 were enrolled in this study. When ''suspicious of invasion to the CL'' was classified as ''no invasion to the CL'' in accordance with the International Federation of Gynecology and Obstetrics (FIGO) criteria, the frequencies of bringing about the correct diagnosis was 83.2% in pelvic (rectal) examination, 76.3% in CT, and 75.0% in MRI, respectively. There was no significant difference in those among the three examinations. If suspicious of invasion to the CL'' was regarded as ''positive invasion'', the frequencies of bringing about the correct diagnosis was 84.0% in pelvic (rectal) examination, 62.2% in CT, and 63.9% in MRI. Concerning invasion to the CL, the diagnosis by pelvic (rectal) examination was significantly more accurate than that by CT as well as MRI. This result suggests that CT and MRI are not superior to pelvic examination regarding detection of the invasion to the CL in the uterine cervical cancers. (author)

2001-01-01

122

Inhibin-betaA and -betaB subunits in normal and malignant glandular epithelium of uterine cervix and HeLa cervical cancer cell line.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Inhibins, dimeric peptide hormones composed of an alpha-subunit and one of two possible beta-subunits (betaA or betaB), exhibit substantial roles in human reproduction and in endocrine-responsive tumors. However, it is still unclear if normal and cancerous cervical glandular epithelial cells as well as cervical cancer cell lines of glandular origin express the inhibin-betaA and -betaB subunits. MATERIALS AND METHODS: Normal cervical tissue samples and a total of 10 specimens of well-differentiated adenocarcinomas of the human cervix were analyzed for inhibin-betaA and -betaB subunit expression by immunohistochemical analysis. Additionally, the cervical carcinoma cell line HeLa was analyzed by immunofluorescence and RT-PCR analysis for the expression of inhibin subunits. RESULTS: Immunolabeling of normal and malignant glandular epithelium of human cervical tissue revealed a positive staining reaction for the inhibin-betaA and -betaB subunits. Additionally, the cancer cell line HeLa synthesized both inhibin subunits. When compared to the normal cervical glandular epithelium, the expression of the inhibin beta subunits became significantly reduced in cervical adenocarcinoma tissues. DISCUSSION: In conclusion, we demonstrated a strong, though differential expression pattern of inhibin-betaA and -betaB subunits in normal and malignant glandular epithelial cells of the human uterine cervix. Although the physiological role of inhibins is still quite unclear in cervical tissue, the expression of inhibin-beta-subunits might play an important role in cervical cancer carcinogenesis, since they are significantly down-regulated during pathogenesis in cervical adenocarcinomas.

Burges A; Shabani N; Brüning A; Mylonas I

2011-10-01

123

Genomic amplification of the human telomerase gene (hTERC) associated with human papillomavirus is related to the progression of uterine cervical dysplasia to invasive cancer  

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Full Text Available Abstract Background Human papillomavirus (HPV) infection plays an etiological role in the development of cervical dysplasia and cancer. Amplification of human telomerase gene (hTERC) and over expression of telomerase were found to be associated with cervical tumorigenesis. This study was performed to analyze genomic amplification of hTERC gene, telomerase activity in association with HPV infection in different stages of cervical intraepithelial neoplasia (CIN) and cervical cancer. We were studying the role of hTERC in the progression of uterine cervical dysplasia to invasive cancer, and proposed an adjunct method for cervical cancer screening. Methods Exfoliated cervical cells were collected from 114 patients with non neoplastic lesion (NNL, n=27), cervical intraepithelial neoplasia (CIN1, n=26, CIN2, n=16, CIN3, n=24) and cervical carcinoma (CA, n=21), and analyzed for amplification of hTERC with two-color fluorescence in situ hybridization (FISH) probe and HPV-DNA with Hybrid Capture 2. From these patients, 53 were taken biopsy to analyze telomerase activity by telomeric repeat amplification protocol (TRAP) and expression of human telomerase reverse transcriptase (hTERT), with immunohistochemistry (IHC). All biopsies were clinically confirmed by phathologists. Results Amplification of hTERC was significantly associated with the histologic diagnoses (p Conclusions hTERC ampliffication can be detected with FISH technique on exfoliated cervical cells. Amplification of hTERC and HPV infection are associated with more progressive CIN3 and CA. The testing of hTERC amplification might be a supplementary to cytology screening and HPV test, especially high-risk patients. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1857134686755648.

Liu Hongqian; Liu Shanling; Wang He; Xie Xiaoyan; Chen Xinlian; Zhang Xuemei; Zhang Youcheng

2012-01-01

124

El cáncer cervicouterino y las lesiones precursoras: revisión bibliográfica/ Cervical-uterine cancer and precursor lesions: a literature review  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Con el objetivo de actualizar el estado del arte sobre el cáncer cervicouterino y las lesiones precursoras se realizó una revisión bibliográfica de los artículos publicados en los últimos 5 años, y de otros originales teniendo en cuenta su nivel de evidencia médica I - II. Se utilizaron los buscadores de la biblioteca Cochrane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, J Clinical Oncology, Medscape, PubMed, PubMed Central y artícu (more) los de la Agencia Internacional del Cáncer de Francia. Se revisaron los siguientes aspectos: Definiciones, epidemiología, etiología, factores de riesgo, citología, colposcopia, histopatología, clasificaciones, estadios clínicos, tratamientos, prevención, promoción de salud y problemas sociales. El cáncer cervicouterino es una enfermedad prevenible y curable, multifactorial, trasmitida sexualmente por el Virus del Papiloma Humano, con alta incidencia y prevalencia, y a pesar de los programas de pesquisaje continúa siendo un problema de salud. Se necesita de monitoreo permanente del programa de detección precoz en todos los ámbitos y alternativas de pesquisaje, adecuadas localmente a las necesidades, y de fuertes prevención y tratamiento para poder disminuir la carga social y económica que de este problema se derivan. Abstract in english Aimed at knowing the state of the art of cervical-uterine cancer and precursor lesions a literature review was carried out supported on the articles published in the last five years and from other original sources considering the levels I-II of medical evidences. Health information sources from Cochrane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, Journal of Clinical Oncology, Medscape, PubMed, Central PubMed and French International Cancer (more) Agency were used to revise the following aspects: definitions, epidemiology, etiology, risk factors, cytology, colposcopy, histopathology, classifications, clinical stages, treatments, prevention, health promotion and social problems. Cervical-uterine is a preventable, curable and multifactorial disease that is sexually transmitted by Human Papilloma Virus, presenting a high incidence and prevalence. Despite continuing screening programs, it is a health problem. Permanent monitoring programs to the early detection of this entity from all scopes must be carried out, along with screening alternatives that should be adjusted to the local needs, as well as the design of prevention and treatment programs to reduce social and economic burden resulting from this health problem.

Sanabria Negrín, José Guillermo; Fernández Montequín, Zoila C; Cruz Hernández, Inalvis de la Caridad; Pérez, Leonardo Oriolo; Llanuch Lara, Margarita

2011-12-01

125

The cytoimmunological effect of concomitant use of sizofiran (SPG) on advanced uterine cervical cancer treated with radiation  

International Nuclear Information System (INIS)

The immunological effect has been studied, using of non-specific immunopotentiator sizofiran (SPG) on the patients with advanced uterine cervical cancer treated with radiation. Ten cases (study group : SPG group) were administered weekly 40 mg of SPG through out the course of radiation and two weekly 40 mg during 12 months after radiotherapy. Nineteen cases (control group) were treated with irradiation alone. The lymphocyte count, the PHA index and the ratio of CD4 cells/CD8 cells were significantly reduced by radiotherapy, being observed the most remarkable decrease at post-radiotherapy. But in SPG group, these decreasing value were significantly smaller than in control group and the value showed a more progressive rise during the 12 month respectively. There was no significant difference in peripheral T lymphocyte ; CD3, CD4, CD8. The NK cytotoxic activity showed a progressive rise during the 12 month period following a minimal change after radiotherapy. These results suggest that the SPG have some enhancing effect on the function of the lymphocytes. (author)

1989-01-01

126

Sizofiran augmented the capacity for interleukin-2 and interferon-? production in patients with uterine cervical cancer under pelvic radiotherapy  

International Nuclear Information System (INIS)

The anti-tumor polysaccharide, sizoferan (SPG), is known as one of the effective biological modifiers which can mediate immunological reaction through a T cell activation pathway. We analyzed the effects of SPG on the production of interleukin-2 (IL-2) and interferon-? (IFN-?) on peripheral mononuclear cells (PMC) in 16 patients with uterine cervical cancer under primary pelvic irradiation. A dose of 20 mg/week of SPG was intramuscularly administered under radiotherapy to 10 patients, and 6 patients were treated by pelvic irradiation without any anti-tumor drugs as a control group. In the control group (pelvic radiotherapy alone), the abilities to produce IL-2 and IFN-? on PMC were markedly diminished at day 10 of irradiation and continued at a low level during radiotherapy, indicating even local irradiation on the lower abdomen can systematically suppress the immune system in a tumor bearing host. In contrast, the experimental group given a weekly injection of SPG showed enhanced productivity of both cytokines (129.5±53.9% (IL-2), 114.5±23.1% (IFN-?)) compared to that before radiotherapy (p

1991-01-01

127

The cytoimmunological effect of concomitant use of sizofiran (SPG) on advanced uterine cervical cancer treated with radiation  

Energy Technology Data Exchange (ETDEWEB)

The immunological effect has been studied, using of non-specific immunopotentiator sizofiran (SPG) on the patients with advanced uterine cervical cancer treated with radiation. Ten cases (study group : SPG group) were administered weekly 40 mg of SPG through out the course of radiation and two weekly 40 mg during 12 months after radiotherapy. Nineteen cases (control group) were treated with irradiation alone. The lymphocyte count, the PHA index and the ratio of CD4 cells/CD8 cells were significantly reduced by radiotherapy, being observed the most remarkable decrease at post-radiotherapy. But in SPG group, these decreasing value were significantly smaller than in control group and the value showed a more progressive rise during the 12 month respectively. There was no significant difference in peripheral T lymphocyte ; CD3, CD4, CD8. The NK cytotoxic activity showed a progressive rise during the 12 month period following a minimal change after radiotherapy. These results suggest that the SPG have some enhancing effect on the function of the lymphocytes. (author).

Iwanari, Osamu; Miyako, Jinya; Ryuko, Kanji; Date, Yoshie; Moriyama, Masashi; Moriyama, Masayuki; Kijima, Satoshi; Yoshino, Naoki; Kitao, Manabu (Shimane Medical Univ., Izumo (Japan))

1989-10-01

128

A case of entero-cutaneous and vesico-enteral fistula due to radiation for uterine cervical carcinoma  

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Late-phase complications of the intestinal and the urinary tracts due to radiation therapy are very difficult to manage, and ensuing fistulation sometimes necessitates surgrey. We report excellent surgical results for a fistula incuded by radiation therapy in a 61-years-old woman. There were previous histories of receiving combined surgical and radiation (up to 10,000 rad) therapy for a uterine cervical carcinoma at another hospital in 1990, and undergoing several surgical treatments for the consequenct vesico-enteral and vesico-colic fistulas. In January, 1993, the patient was admitted to the department of urology of this hospital because of an abdominal pain, and was transferred to the department under a diagnosis of entero-cutaneous and vesico-enteral fistulas. After local sump suction and skin care, resection of the fistula and involved small intestine conserving the urinary tract was performed, and the omentum was transferred to the resected space. Cholecystectomy was carried out for cholelithiasis. Histological studies revealed atrophy in the mucosal layer and edema in the submucosal layer. Her postoperative course has been satisfactory without any signs of fistulation as of one year after the operation. (author).

Iwakawa, Kazuhide; Kadota, Takeshi; Kobayashi, Nobuaki [Ehime Univ., Shigenobu (Japan). School of Medicine; Ohnishi, Goro

1994-11-01

129

A case of entero-cutaneous and vesico-enteral fistula due to radiation for uterine cervical carcinoma  

International Nuclear Information System (INIS)

[en] Late-phase complications of the intestinal and the urinary tracts due to radiation therapy are very difficult to manage, and ensuing fistulation sometimes necessitates surgrey. We report excellent surgical results for a fistula incuded by radiation therapy in a 61-years-old woman. There were previous histories of receiving combined surgical and radiation (up to 10,000 rad) therapy for a uterine cervical carcinoma at another hospital in 1990, and undergoing several surgical treatments for the consequenct vesico-enteral and vesico-colic fistulas. In January, 1993, the patient was admitted to the department of urology of this hospital because of an abdominal pain, and was transferred to the department under a diagnosis of entero-cutaneous and vesico-enteral fistulas. After local sump suction and skin care, resection of the fistula and involved small intestine conserving the urinary tract was performed, and the omentum was transferred to the resected space. Cholecystectomy was carried out for cholelithiasis. Histological studies revealed atrophy in the mucosal layer and edema in the submucosal layer. Her postoperative course has been satisfactory without any signs of fistulation as of one year after the operation. (author)

1994-01-01

130

A fusion-based approach for uterine cervical cancer histology image classification.  

UK PubMed Central (United Kingdom)

Expert pathologists commonly perform visual interpretation of histology slides for cervix tissue abnormality diagnosis. We investigated an automated, localized, fusion-based approach for cervix histology image analysis for squamous epithelium classification into Normal, CIN1, CIN2, and CIN3 grades of cervical intraepithelial neoplasia (CIN). The epithelium image analysis approach includes medial axis determination, vertical segment partitioning as medial axis orthogonal cuts, individual vertical segment feature extraction and classification, and image-based classification using a voting scheme fusing the vertical segment CIN grades. Results using 61 images showed at least 15.5% CIN exact grade classification improvement using the localized vertical segment fusion versus global image features.

De S; Stanley RJ; Lu C; Long R; Antani S; Thoma G; Zuna R

2013-09-01

131

Knowledge, attitudes and practices on cervical cytology-uterine in women from sincelejo and Cartagena, colombia  

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Full Text Available Although in Colombia screening programs of cervical cancer have achieved high levelsof coverage, cervical cancer has the first places in incidence and mortality. There isthe need to identify factors influencing it, among them is to investigate the level ofawareness of women about the screening test, their attitudes to screening and itspractices. For this we made a survey of 505 women 13 to 60 years who have had sexual life, living in the cities of Cartagena and Sincelejo (Colombia).The results showthat virtually all women have knowledge of cervical cytology, 94.5% of women havemade at least once. This percentage is higher in the range of 40 to 60 years where itreaches 99% in younger women this percentage decrease. In defining its usefulness,only 73.8% responded accurately. 50% reported unpleasant aspects related to themaking of the cytology, such as fear, and fear of a cancer diagnosis. A fail to rememberis the main factor for not claiming the results.These data show that the percentage ofwomen with sexual life that ignores the usefulness of cytology or never have practicedis minimal, which leads to the conclusion that ineffective screening programs to reducecervical cancer rates depends on other factors that should be investigated.RESUMEN:Aunque en Colombia los programas de prevención del cáncer de cérvix han alcanzadoaltos niveles de cobertura, todavía este ocupa los primeros lugares en incidencia ymortalidad. Existe la necesidad de identificar los factores que influyen en ello, por tantoes importante investigar el nivel de conocimiento de las mujeres sobre la prueba detamizaje, su actitud frente a la misma y sus prácticas relacionadas. Se realizó encuestaa 505 mujeres entre 13 y 60 años edad, que habían tenido vida sexual, residentes en lasciudades de Cartagena y Sincelejo (Colombia). Los resultados revelan que prácticamentetodas las mujeres tienen conocimientos sobre citología cérvico-uterina. El 94.5% delas mujeres se la han realizado por lo menos una vez. Este porcentaje es mayor en elrango de 40 a 60 años donde alcanza el 99%, y en las de menor edad este porcentajedisminuye. Al definir su utilidad: solo el 73.8% respondió de manera acertada. El 50%refieren aspectos desagradables en relación con la toma de la citología, como el miedoy el temor a un diagnóstico de cáncer y el olvido es el principal factor para no reclamarlos resultados. Estos datos demuestran que el porcentaje de mujeres con vida sexualque desconocen la utilidad de la citología o nunca se la han practicado es mínimo, locual permite concluir que la ineficacia de los programas de tamizaje para disminuir lascifras de cáncer de cérvix en nuestro medio depende de otros factores que deben serevaluados.

Barrrios-Garcia Lia; Benedetti-Padrón Inés; Alvis-Estrada Luis; Arroyo-Salgado Bárbara

2011-01-01

132

Advanced Composite of Large Cell Neuroendocrine Carcinoma and Squamous Cell Carcinoma: A Case Report of Uterine Cervical Cancer in a Virgin Woman  

Science.gov (United States)

Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is very rare and aggressive. The prognosis is very poor despite multimodal treatment. We report a virgin woman with FIGO stage 4b LCNEC of uterine cervix coexisting with squamous cell carcinoma. An early thirties virgin woman presented with 2-month history of abdominal pain. A chest X-ray showed multiple lung metastatic tumors. A vaginal smear showed malignant cells, and a biopsy specimen had features of LCNEC. The tumor showed trabecular patterns. Tumor cells possessed a moderate amount of cytoplasm, prominent nucleoli, and large nuclei. The tumor cells are stained positive for synaptophysin, chromogranin A, and neuron specific enolase (NSE). The invasive tumor cells in connection with cervical squamous epithelium were focally positive for 34bE12. We made a diagnosis of composite LCNEC and nonkeratinizing squamous cell carcinoma. High-risk HPV test was negative with hybridized captured method 2.

Kou, Iemasa; Date, Kenjiro; Nakayama, Hirofumi

2013-01-01

133

Melanosis of the uterine cervix: a case report and literature review/ Melanose cervical uterina: relato de caso e revisão da literatura  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A melanose cervical uterina representa lesão melanocítica extremamente rara, devendo ser diferenciada do melanoma. Trata-se de uma hiperpigmentação melanocítica das células da camada basal da mucosa escamosa do colo uterino sem aumento no número de melanócitos. Apresenta-se, neste artigo, um caso característico dessa entidade, além da discussão acerca das possíveis origens dos melanócitos nessa região, bem como sua relação com a síndrome de Laugier-Hunziker e o complexo de Carney. Abstract in english Melanosis of the uterine cervix is an extremely rare melanocytic lesion and should be differentiated from melanoma. It is a melanocytic hyperpigmentation of basal layer cells from the squamous mucosa of the uterine cervix without an increase in the number of melanocytes. We present a typical case of this entity. Furthermore, we discuss the possible origins of melanocytes in this region and their association with Laugier-Hunziker syndrome and Carney complex.

Chang, Daniel; Tiburzio, Gerusa Biagione

2013-06-01

134

Successful tubal blastocyst transfer after laparoscopic cervical cerclage: cesarean delivery of a live very low-birth-weight infant and later hysterectomy for uterine rupture.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To report the management of a woman who presented with secondary infertility and amenorrhea after 2 Lletz procedures and a cone biopsy and who had cervical stenosis, a foreshortened cervix, and hematometra. DESIGN: Case report. SETTING: Fertility clinic and tertiary hospital. PATIENT(S): A 34-year-old woman who wanted further children but had had a previous cesarean delivery and then a cone biopsy for cervical intraepithelial neoplasia III that resulted in a foreshortened cervix and cervical obstruction. INTERVENTION(S): Laparoscopic cervical cerclage, IVF, blastocyst tubal transfer, cesarean delivery, hysterectomy. MAIN OUTCOME MEASURE(S): Pregnancy; morbidity for the woman and her infant. RESULT(S): An intrauterine pregnancy occurred after blastocyst intrafallopian transfer, but there was uterine herniation necessitating premature delivery of a very low-birth-weight infant that had lung problems but is now healthy. The mother later developed a hematometra that ruptured, requiring an emergency hysterectomy from which her recovery was protracted. CONCLUSION(S): This first report of a blastocyst intrafallopian transfer was associated with an intrauterine pregnancy; however, when the indication for blastocyst tubal transfer of an obstructed cervix is associated with a foreshortened cervix requiring cervical cerclage, there can be major health risks for infant and mother.

Murray A; Hutton J

2011-10-01

135

Uterine evacuator  

UK PubMed Central (United Kingdom)

A system for achieving evacuation of tissue from within the uterine cavity. A rotating Archimedes screw within a narrow cylindrical sheath achieves mechanical tissue extraction. A vacuum source attached to the sheath removes the extracted tissue from the sheath by suction. A fiber-optic system integrated into the sheath allows the procedure to be performed under direct visual guidance. The narrow diameter of the sheath allows for performance of the procedure without the need for cervical dilation.

TUGENDREICH DANIEL; ZION BEN-RAFAEL

136

Pre-Treatment Diffusion-Weighted MR Imaging for Predicting Tumor Recurrence in Uterine Cervical Cancer Treated with Concurrent Chemoradiation: Value of Histogram Analysis of Apparent Diffusion Coefficients.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate the value of apparent diffusion coefficient (ADC) histogram analysis for predicting tumor recurrence in patients with uterine cervical cancer treated with chemoradiation therapy (CRT). MATERIALS AND METHODS: Our institutional review board approved this retrospective study and waived informed consent from each patient. Forty-two patients (mean age, 56 ± 14 years) with biopsy-proven uterine cervical squamous cell carcinoma who underwent both pre-treatment pelvic magnetic resonance imaging with a 3.0 T magnetic resonance scanner and concurrent CRT were included. All patients were followed-up for more than 6 months (mean, 36.4 ± 11.9 months; range 9.0-52.8 months) after completion of CRT. Baseline ADC parameters (mean ADC, 25th percentile, 50th percentile, and 75th percentile ADC values) of tumors were calculated and compared between the recurrence and no recurrence groups. RESULTS: In the recurrence group, the mean ADC and 75th percentile ADC values of tumors were significantly higher than those of the no recurrence group (p = 0.043 and p = 0.008, respectively). In multivariate analysis, the 75th percentile ADC value of tumors was a significant predictor for tumor recurrence (p = 0.009; hazard ratio, 1.319). When the cut-off value of the 75th percentile ADC (0.936 × 10(-3) mm(2)/sec) was used, the overall recurrence free survival rate above the cut-off value was significantly lower than that below the cut-off value (51.9% vs. 91.7%, p = 0.003, log-rank test). CONCLUSION: Pre-CRT ADC histogram analysis may serve as a biomarker for predicting tumor recurrence in patients with uterine cervical cancer treated with CRT.

Heo SH; Shin SS; Kim JW; Lim HS; Jeong YY; Kang WD; Kim SM; Kang HK

2013-07-01

137

Image-Guided Stereotactic Body Radiation Therapy in Patients With Isolated Para-Aortic Lymph Node Metastases From Uterine Cervical and Corpus Cancer  

International Nuclear Information System (INIS)

[en] Purpose: The aims of this study were to evaluate the role of stereotactic body radiation therapy (SBRT) as a local treatment for isolated para-aortic lymph node (PALN) metastases originating from uterine cervical and corpus cancer. Methods and Materials: We retrospectively enrolled 30 patients with isolated PALN metastases originating from uterine cervical and corpus cancer who had received SBRT using the CyberKnife (CK). All patients were shown to have isolated PALN metastases by computed tomography (CT) and/or positron emission tomography (PET)-CT. The overall survival (OS), local control (LC) rate, and disease progression-free survival (DPFS) rate were calculated according to the Kaplan-Meier method. Comparison between prognosis groups was performed using log-rank analysis. Toxicities were also evaluated. Results: The 4-year OS rate was 50.1%, and the median survival time was not reached. The OS rate among symptomatic patients was significantly lower than that among asymptomatic patients (p = 0.002). The 4-year actuarial LC rate was 67.4%. Patients with a planning target volume of ?17 ml had significantly higher LC rates (p = 0.009). The 4-year DPFS rate was 45.0%, and the median time to disease progression was 32 months. Small planning target volume was a favorable prognostic factor (p = 0.043). Grade 3 or 4 complications requiring hospitalization were reported in 1 patient at 20 months after SBRT. Conclusion: The OS and LS rates were promising, and the incidence of toxicities was low. Use of SBRT with the CyberKnife is an effective modality for treating isolated PALN metastases in patients with uterine cervical and corpus cancer.

2009-05-01

138

Limitation of rectal examination, CT, and MRI as a tool for diagnosing the invasion to cardinal ligaments in the uterine cervical cancers  

Energy Technology Data Exchange (ETDEWEB)

The clinical methods such as pelvic (rectal) examination, CT, and MRI have been commonly used in order to detect invasion to the cardinal ligaments (CL) for determination of preoperative staging in the uterine cervical cacner. We examined the accuracy of their clinical means as for diagnosis of invasion to the CL, compared with histological findings of surgical specimens. One hundred twenty five patients with the uterine cervical cancer stage Ib or stage II who underwent a radical hysterectomy between 1987 and 1999 were enrolled in this study. When ''suspicious of invasion to the CL'' was classified as ''no invasion to the CL'' in accordance with the International Federation of Gynecology and Obstetrics (FIGO) criteria, the frequencies of bringing about the correct diagnosis was 83.2% in pelvic (rectal) examination, 76.3% in CT, and 75.0% in MRI, respectively. There was no significant difference in those among the three examinations. If suspicious of invasion to the CL'' was regarded as ''positive invasion'', the frequencies of bringing about the correct diagnosis was 84.0% in pelvic (rectal) examination, 62.2% in CT, and 63.9% in MRI. Concerning invasion to the CL, the diagnosis by pelvic (rectal) examination was significantly more accurate than that by CT as well as MRI. This result suggests that CT and MRI are not superior to pelvic examination regarding detection of the invasion to the CL in the uterine cervical cancers. (author)

Umemoto, Mika; Yokoyama, Yoshihito; Sato, Shigemi; Saito, Yoshiharu [Hirosaki Univ., Aomori (Japan). School of Medicine

2001-01-01

139

Sizofiran augmented the capacity for interleukin-2 and interferon-. gamma. production in patients with uterine cervical cancer under pelvic radiotherapy  

Energy Technology Data Exchange (ETDEWEB)

The anti-tumor polysaccharide, sizoferan (SPG), is known as one of the effective biological modifiers which can mediate immunological reaction through a T cell activation pathway. We analyzed the effects of SPG on the production of interleukin-2 (IL-2) and interferon-{gamma} (IFN-{gamma}) on peripheral mononuclear cells (PMC) in 16 patients with uterine cervical cancer under primary pelvic irradiation. A dose of 20 mg/week of SPG was intramuscularly administered under radiotherapy to 10 patients, and 6 patients were treated by pelvic irradiation without any anti-tumor drugs as a control group. In the control group (pelvic radiotherapy alone), the abilities to produce IL-2 and IFN-{gamma} on PMC were markedly diminished at day 10 of irradiation and continued at a low level during radiotherapy, indicating even local irradiation on the lower abdomen can systematically suppress the immune system in a tumor bearing host. In contrast, the experimental group given a weekly injection of SPG showed enhanced productivity of both cytokines (129.5{+-}53.9% (IL-2), 114.5{+-}23.1% (IFN-{gamma})) compared to that before radiotherapy (p<0.05). This augmentation of IL-2 productivity was relatively higher than that of IFN-{gamma}. These results suggest that SPG can augment the immunological response in vivo in the myelosuppressed patient under radiotherapy by activating T lymphocytes and macrophage through IL-2 and/or IFN-{gamma}. This positive effect of combination therapy with SPG and anti-tumor cytokines such as IL-2 and IFN-{gamma} may be a useful strategy for advanced cancer. (author).

Koyama, Masayasu; Matsuzaki, Noboru; Ohashi, Kazutomo; Saji, Fumitaka; Tanizawa, Osamu (Osaka Univ. (Japan). Faculty of Medicine)

1991-08-01

140

Interfractional change of high-risk CTV D90 during image-guided brachytherapy for uterine cervical cancer.  

UK PubMed Central (United Kingdom)

The purpose of this study was to evaluate interfractional changes of the minimum dose delivered to 90% of the high-risk clinical target volume (HR-CTV D90) and D2cc of the bladder and rectum during brachytherapy for uterine cervical cancer patients. A total of 52 patients received external beam radiotherapy and high-dose-rate intracavitary brachytherapy (ICBT). For each of four ICBT applications, a pelvic CT scan was performed and the HR-CTV was delineated. Retrospectively, these patients were divided into two groups: (i) the standard dose group with 6 Gy to point A in each ICBT, and (ii) the adaptive dose group with a modified dose to point A to cover the HR-CTV with the 6-Gy isodose line as much as possible. The HR-CTV D90 was assessed in every session, and analyzed as interfractional changes. In the standard dose group, the interfractional changes of the HR-CTV D90 showed a linear increase from the first to the third of the four ICBT (average 6.1, 6.6, 7.0 and 7.1 Gy, respectively). In contrast, those of the adaptive dose group remained almost constant (average 7.2, 7.2, 7.3 and 7.4 Gy, respectively). Especially, in the case of a large HR-CTV volume (?35 cm(3)) at first ICBT, the total HR-CTV D90 of the adaptive dose group with brachytherapy was significantly higher than that of the standard dose group. There were no significant differences in total D2cc in bladder and rectum between the two groups. Image-guided adaptive brachytherapy based on interfractional tumor volume change improves the dose to the HR-CTV while keeping rectal and bladder doses within acceptable levels.

Ohkubo Y; Ohno T; Noda SE; Kubo N; Nakagawa A; Kawahara M; Abe T; Kiyohara H; Wakatsuki M; Nakano T

2013-06-01

 
 
 
 
141

Do clinicians and patients agree regarding symptoms? A comparison after definitive radiochemotherapy in 223 uterine cervical cancer patients  

Energy Technology Data Exchange (ETDEWEB)

Background: In clinical cancer research of morbidity, low associations between clinician-assessed toxicity/morbidity and patient-reported symptoms are consistently described in the literature. While morbidity grading systems are supposed to follow more or less objective criteria, patient reported symptoms inherently are based on a subjective self-evaluation of the impact on quality of life. The aim of this study was to focus on major discrepancies with high clinical relevance and to evaluate its impact with regard to underreporting of morbidity. Material and methods: Early morbidity assessed by clinicians with CTCAEv.3 and patient reported quality of life (EORTC-QLQ-C30/CX24) were compared regarding 12 overlapping symptoms in 223 patients with uterine cervical cancer 3 months after definitive radio(chemo)therapy in the ongoing EMBRACE study. Mismatches showing discrepancies between both grading systems were classified, if patients reported substantial symptoms (quite a bit/very much) and CTCAE grading was rated G0. Results: In total, 360 substantial symptoms were reported by patients by EORTC-QLQ; 159 (44%) of those were not recognized by CTCAE. Symptoms with the highest occurrence of mismatches overall are urinary frequency, fatigue, and insomnia. Large institutional differences were found, showing two centers with 4 vs. 71% of patients with at least one mismatch. Conclusion: Analysis of mismatches indicated a high risk of underestimation of early morbidity. Thus, nearly half of the patient-reported substantial symptoms were not recognized by CTCAE scoring (G0) 3 months after treatment. Prospective assessment of morbidity in clinical studies should, therefore, integrate patient reported symptoms to receive a complete and comprehensive picture. (orig.)

Kirchheiner, K.; Poetter, R. [Medical Univ. Vienna (Austria). Dept. of Radiotherapy; Nout, R. [University Medical Center Leiden (Netherlands). Dept. of Clinical Oncology; Lindegaard, J. [University Hospital Aarhus (Denmark). Dept. of Oncology; Petric, P. [Institute of Oncology Ljubljana (Slovenia). Dept. of Radiotherapy; Limbergen, E.V. [University Hospital Leuven (Belgium). Dept. of Radiotherapy; Juergenliemk-Schulz, I.M. [University Medical Center Utrecht (Netherlands). Dept. of Radiation Oncology; Haie-Meder, C. [Institut Gustave-Roussy, Villejuif (France). Dept. of Radiotherapy; Doerr, W. [Technische Univ. Dresden (Germany). Dept. of Radiotherapy and Radiooncology

2012-10-15

142

Do clinicians and patients agree regarding symptoms? A comparison after definitive radiochemotherapy in 223 uterine cervical cancer patients  

International Nuclear Information System (INIS)

[en] Background: In clinical cancer research of morbidity, low associations between clinician-assessed toxicity/morbidity and patient-reported symptoms are consistently described in the literature. While morbidity grading systems are supposed to follow more or less objective criteria, patient reported symptoms inherently are based on a subjective self-evaluation of the impact on quality of life. The aim of this study was to focus on major discrepancies with high clinical relevance and to evaluate its impact with regard to underreporting of morbidity. Material and methods: Early morbidity assessed by clinicians with CTCAEv.3 and patient reported quality of life (EORTC-QLQ-C30/CX24) were compared regarding 12 overlapping symptoms in 223 patients with uterine cervical cancer 3 months after definitive radio(chemo)therapy in the ongoing EMBRACE study. Mismatches showing discrepancies between both grading systems were classified, if patients reported substantial symptoms (quite a bit/very much) and CTCAE grading was rated G0. Results: In total, 360 substantial symptoms were reported by patients by EORTC-QLQ; 159 (44%) of those were not recognized by CTCAE. Symptoms with the highest occurrence of mismatches overall are urinary frequency, fatigue, and insomnia. Large institutional differences were found, showing two centers with 4 vs. 71% of patients with at least one mismatch. Conclusion: Analysis of mismatches indicated a high risk of underestimation of early morbidity. Thus, nearly half of the patient-reported substantial symptoms were not recognized by CTCAE scoring (G0) 3 months after treatment. Prospective assessment of morbidity in clinical studies should, therefore, integrate patient reported symptoms to receive a complete and comprehensive picture. (orig.)

2012-01-01

143

Phase II trial on neoadjuvant intravenous and trans-uterine arterial chemotherapy for locally advanced bulky cervical adenocarcinoma.  

UK PubMed Central (United Kingdom)

OBJECTIVE: A phase II trial on neoadjuvant trans-uterine arterial chemotherapy (TUAC) followed by type III radical hysterectomy (RH) was conducted for patients with bulky cervical adenocarcinoma (AC). METHODS: Tumors of >4 cm were eligible. The neoadjuvant regimen comprised paclitaxel (60 mg/m(2) intravenously on days 1, 8, and 15) and cisplatin (70 mg/m(2) TUAC followed by transcatheter embolization with gelatin sponge particles on day 2) repeated every 3 weeks for 3 cycles. The primary endpoints were clinical and pathological responses. RESULTS: Twenty-two patients (median age, 51 years; range, 33-75 years) were enrolled. The International Federation of Gynecology and Obstetrics stages were IB2 (9 patients), IIA-IIB (8), IIIB (3), and IVA (2). The adeno/adenosquamous ratio was 16/6. The overall clinical response rate was 95.4% (95% confidence interval [CI], 86.7-100%). RH was completed in 19 patients (86%), including 2 stage IVA patients who underwent anterior or posterior pelvic exenteration. Of the 19 patients, no residual malignant cells were found pathologically in 4; thus, the pathological complete response rate was 18% (4/22). No patients experienced grade 4 thrombocytopenia or febrile neutropenia or required platelet transfusions. The 5-year progression-free survival and overall survival rates in stages IB2-IIB were 70.0% (95%CI, 48.1-92.1%) and 69.5% (95%CI, 47.0-92.0%), respectively. The 2 patients with stage IVA tumors were alive without recurrence for 72 and 84 months after enrollment. CONCLUSIONS: TUAC showed high clinical and pathological response rates. TUAC is promising for stage IB2-IIB and IVA bulky AC.

Tsubamoto H; Maeda H; Kanazawa R; Ito Y; Ohama N; Hori M; Ikeda Y; Kato T; Sakane R; Hirota S

2013-04-01

144

Lymphoscintigraphy using epidermal growth factor as tumour-seeking agent in uterine cervical cancer  

International Nuclear Information System (INIS)

[en] Fourteen patients suffering from advanced inoperable cervical cancer were investigated by planar scintigraphy after subcutaneous administration of a radiolabelled (I-123) epidermal growth factor (EGF). The objective of the study was to test whether labelled EGF concentrates in lymph node metastases of squamous cell cancer of the cervix uteri. Scintigraphic results were correlated with the gynecological findings, computed tomography (CT), ultrasound (US) and in two patients with histology. A series of scintigrams were performed up to 24 hours post injection. Slight activity in liver and kidneys was found already 30 min after s.c. injection of EGF. Optimal imaging quality for the lymphatics was obtained at 6-8 hours post injection. Accumulation in the pelvic lymph nodes was documented by the region of interest technique (ROI). Lymph nodes of the inguinal and iliac communis region were marked in all cases. Due to this, accumulation of EGF could not be called selective. In 11/14 patients hot spots were correlated to other pelvic lymph nodes. In 4/11 patients with positive EGF-scanning metastatic disease was confirmed by CT scan and/or US examination. 2/11 patients underwent a Probatoria operation. The respective histological reports confirmed our scintigraphic results. In conclusion, labelled EGF did not fulfil our theoretical expectations of excellent accumulation in lymph node metastases and cannot at present be recommended for routine clinical use. (authors)

1991-01-01

145

Human papillomavirus 16-positive uterine cervical squamous cell carcinoma with coinfection with human papillomavirus 34 has a lower incidence in lymph node metastasis than that without coinfection with human papillomavirus 34.  

UK PubMed Central (United Kingdom)

Our earlier study demonstrated high prevalence of multiple human papillomavirus (HPV) infection in patients with invasive uterine cervical cancer, including squamous cell carcinoma (SCC). HPV 16 is the most predominant genotype related to SCC of the uterine cervix. The aim of this study was to reveal the biological significance of multiple HPV infection concerning the tumor progression of invasive uterine cervical SCC. In the present study, the effects of coinfection with genotypes other than HPV 16 on tumor growth and lymph node metastasis of invasive uterine cervical SCC with HPV 16 infection were examined. Although coinfection with most genotypes did not influence tumor progression, the clinical stage of patients coinfected with HPV 16 and HPV 34 was significantly lower than that of those without HPV 34 coinfection (p = 0.0038). Moreover, no patient coinfected with HPV 16 and HPV 34 manifested lymph node metastasis, but about half of the patient population without HPV 34 coinfection did (p = 0.0299). These findings suggested that coinfection with HPV 34 could prevent the tumor progression of invasive uterine cervical SCC with HPV 16 infection.

Michimata R; Watari H; Tomaru U; Sakuragi N; Ishizu A

2013-01-01

146

Transition of Ki-67 index of uterine cervical tumors during radiation therapy. Immunohistochemical study  

International Nuclear Information System (INIS)

[en] Histopathologic and Ki-67-staining features of cancer cells were investigated in biopsy specimens before and during radiation therapy in 29 patients with cervical squamous cell carcinoma. No morphologic changes were observed up to doses of 540 cGy. A few intact cancer cells remained up to doses of 2700 cGy. Moderate changes in the cancer cells were noticed in patients who received 900 cGy or more, i.e., multinuclei, swollen nuclei and cytoplasms, and prominent large nucleoli. At doses of 1800 cGy or greater, many cancer nests had severely damaged cancer cells with features such as cytolysis, karyolysis, karyorrhexis, pyknosis, and bizarre giant cells. There was no mitosis in the cells of patients who received doses greater than 1800 cGy. The Ki-67-positive cancer cells showed diffuse nuclear-stainings and dot-stainings before radiation therapy. Radiation doses more than 900 cGy changed the staining pattern of the Ki-67 antibody; large irregular spot-stainings and ring-stainings were observed predominantly. The Ki-67 index initially increased with the radiation dose; the mean Ki-67 indices before radiation therapy and at radiation doses of 180 cGy, 540 cGy, and 900 cGy were 41%, 50%, 63%, and 68%, respectively. The indices decreased when the dose was increased further, and they were 39% and 20% at doses of 1800 cGy and 2700 cGy, respectively. Possible explanations, including recruitment of quiescent cells, for the change in Ki-67 staining are discussed

1991-08-01

147

Transition of Ki-67 index of uterine cervical tumors during radiation therapy. Immunohistochemical study  

Energy Technology Data Exchange (ETDEWEB)

Histopathologic and Ki-67-staining features of cancer cells were investigated in biopsy specimens before and during radiation therapy in 29 patients with cervical squamous cell carcinoma. No morphologic changes were observed up to doses of 540 cGy. A few intact cancer cells remained up to doses of 2700 cGy. Moderate changes in the cancer cells were noticed in patients who received 900 cGy or more, i.e., multinuclei, swollen nuclei and cytoplasms, and prominent large nucleoli. At doses of 1800 cGy or greater, many cancer nests had severely damaged cancer cells with features such as cytolysis, karyolysis, karyorrhexis, pyknosis, and bizarre giant cells. There was no mitosis in the cells of patients who received doses greater than 1800 cGy. The Ki-67-positive cancer cells showed diffuse nuclear-stainings and dot-stainings before radiation therapy. Radiation doses more than 900 cGy changed the staining pattern of the Ki-67 antibody; large irregular spot-stainings and ring-stainings were observed predominantly. The Ki-67 index initially increased with the radiation dose; the mean Ki-67 indices before radiation therapy and at radiation doses of 180 cGy, 540 cGy, and 900 cGy were 41%, 50%, 63%, and 68%, respectively. The indices decreased when the dose was increased further, and they were 39% and 20% at doses of 1800 cGy and 2700 cGy, respectively. Possible explanations, including recruitment of quiescent cells, for the change in Ki-67 staining are discussed.

Nakano, T.; Oka, K. (Section of Medical Affairs, National Institute of Radiological Sciences, Chiba (Japan))

1991-08-01

148

Complete uterine septum with cervical duplication, longitudinal vaginal septum and duplication of a renal collecting system. A case report.  

UK PubMed Central (United Kingdom)

BACKGROUND: The incidence of congenital uterine anomalies in the general population is estimated at 0.001-10%. Müllerian defects are associated with an increased incidence of urinary anomalies, an increased risk of infertility, early pregnancy loss, premature rupture of membranes, preterm labor and malpresentation. CASE: A 34-year-old, infertile woman with a presumed diagnosis of uterine didelphys and a longitudinal vaginal septum was noted to have a thin, communicating membrane separating the uterine horns on magnetic resonance imaging (MRI). A communication between these two horns was noted on hysterosalpingography (HSG). The diagnosis of complete uterine septum was therefore established. Uterine leiomyomata and a complete duplication of the right renal collecting system were also noted. CONCLUSION: Cases of complete uterine and vaginal septum can be easily confused with uterine didelphys. Management of these two müllerian anomalies is different, with surgical correction usually needed in cases of complete uterine septum. The use of pelvic ultrasound, MRI and HSG aided in correctly diagnosing this unusual form of müllerian anomaly.

Sharara FI

1998-12-01

149

Regeneration of uterine cervix at 6 months after large loop excision of the transformation zone for cervical intraepithelial neoplasia.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To sonographically investigate cervical regeneration 6 months after large loop excision of the transformation zone (LLETZ) conisation for cervical intraepithelial neoplasia (CIN) pathology. DESIGN: Prospective observational study. SETTING: University Hospital setting. POPULATION: Women having LLETZ conisation for intraepithelial lesions in response to abnormal Papanicolaou smears or colposcopic findings. METHODS: Cervical dimensions were estimated before conisation and at 6 months with three-dimensional sonography and use of vocal™ software. Cone depth was measured using a ruler before fixation, and cone volume was measured using a volumetric tube and the fluid displacement technique. Cervical regeneration was sonographically estimated. MAIN OUTCOME MEASURES: Correlation of cervical volume regeneration with percentage of initial cervical volume excised and remaining cervical tissue immediately after conisation. RESULTS: A cohort of 112 women were initially recruited over a 2-year period and 73 women presented for ultrasound follow up at 6 months. Multivariate linear regression analysis showed that for women matched for age and initial cervical volume, if cervical volume excised was increased by 1% then regeneration of tissue deficit at the cervical crater was reduced by 1.37%. There also seemed to be a cutoff point suggesting that when >14% of initial cervical volume was excised, the tissue deficit at the cervical crater at 6 months was restored by <75% and there was >25% of remaining tissue deficit. CONCLUSIONS: Cervical regeneration at 6 months after excision is dependent on the percentage of initial cervical volume excised and on the remaining cervical tissue immediately after conisation. The greater the cone and the less cervical tissue remaining, the less the degree of cervical regeneration achieved.

Papoutsis D; Rodolakis A; Mesogitis S; Sotiropoulou M; Antsaklis A

2012-05-01

150

The Frequency and Clinical Significance of Intra-amniotic Inflammation in Women With Preterm Uterine Contractility but Without Cervical Change: Do the Diagnostic Criteria for Preterm Labor Need to be Changed?  

Science.gov (United States)

OBJECTIVE The objective of this study was to determine the frequency and clinical significance of intra-amniotic inflammation in patients with preterm increased uterine contractility with intact membranes but without cervical change. METHODS Amniocentesis was performed in 132 patients with regular uterine contractions and intact membranes without cervical change. Amniotic fluid was cultured for bacteria and mycoplasmas and assayed for matrix metalloproteinase-8 (MMP-8). Intra-amniotic inflammation was defined as an elevated amniotic fluid MMP-8 concentration (>23 ng/mL). RESULTS 1) Intra-amniotic inflammation was present in 12.1% (16/132); 2) Culture-proven intra-amniotic infection was diagnosed in 3% (4/132) of patients without demonstrable cervical change on admission or during the period of observation; and 3) Patients with intra-amniotic inflammation had significantly higher rates of preterm delivery and adverse outcomes, and shorter amniocentesis-to-delivery intervals than those without intra-amniotic inflammation (P < .05 for each). Adverse outcomes included chorioamnionitis, funisitis, and neonatal death. CONCLUSION Intra-amniotic inflammation was present in 12% of patients with regular uterine contractions without cervical change, while culture-proven intra-amniotic infection was present in 3%. The presence of intra-amniotic inflammation was a significant risk factor for adverse neonatal outcomes. These observations question whether cervical changes should be required for the diagnosis of preterm labor, because patients without modifications in cervical status on admission or during a period of observation are at risk for adverse pregnancy outcomes.

KIM, Sun Min; ROMERO, Roberto; LEE, JoonHo; LEE, Seung Mi; PARK, Chan-Wook; PARK, Joong Shin; YOON, Bo Hyun

2011-01-01

151

The diagnosis of uterine cervical polyps in a low resource setting: the positive predictive value of clinical judgment--a series of 192 cases at the Yaounde Gynaeco-Obstetric and Paediatric Hospital, Cameroon.  

Science.gov (United States)

As far as we know, the accuracy of clinical judgment in diagnosing uterine cervical polyps has not been assessed in sub-Saharan Africa. Our objective was to discover the positive predictive value (PPV) of clinical judgment in the diagnosis of cervical polyps. This is a retrospective descriptive study of 192 patients, carried out by the Departments of Pathology and Gynaecology of the Yaoundé Gynaeco-Obstetric and Paediatric Hospital, Cameroon. The diagnosis of cervical polyp was confirmed by histopathology examination in 169 patients, giving a PPV rate of 88.0%. The PPV of clinical judgment in the diagnosis of cervical polyps is acceptable in our setting but the frequency of premalignant and malignant lesions encountered is too high (10.4%), even in the presence of a confirmed cervical polyp (8.9%). Even in areas where there are limited resources, we recommend a systematic histopathology examination of any clinically suspected cervical polyp. PMID:23796672

Foumane, Pascal; Sando, Zacharie; Dohbit, Julius Sama; Bilo'o, Lydienne Lesly; Mboudou, Emile Telesphore; Oyono, Jean Louis Essame

2013-06-11

152

The diagnosis of uterine cervical polyps in a low resource setting: the positive predictive value of clinical judgment--a series of 192 cases at the Yaounde Gynaeco-Obstetric and Paediatric Hospital, Cameroon.  

UK PubMed Central (United Kingdom)

As far as we know, the accuracy of clinical judgment in diagnosing uterine cervical polyps has not been assessed in sub-Saharan Africa. Our objective was to discover the positive predictive value (PPV) of clinical judgment in the diagnosis of cervical polyps. This is a retrospective descriptive study of 192 patients, carried out by the Departments of Pathology and Gynaecology of the Yaoundé Gynaeco-Obstetric and Paediatric Hospital, Cameroon. The diagnosis of cervical polyp was confirmed by histopathology examination in 169 patients, giving a PPV rate of 88.0%. The PPV of clinical judgment in the diagnosis of cervical polyps is acceptable in our setting but the frequency of premalignant and malignant lesions encountered is too high (10.4%), even in the presence of a confirmed cervical polyp (8.9%). Even in areas where there are limited resources, we recommend a systematic histopathology examination of any clinically suspected cervical polyp.

Foumane P; Sando Z; Dohbit JS; Bilo'o LL; Mboudou ET; Oyono JL

2013-04-01

153

Vírus HPV e câncer de colo de útero Virus HPV y el cáncer del cuello uterino Human Papillomavirus (HPV) and uterine cervical cancer  

Directory of Open Access Journals (Sweden)

Full Text Available Este artigo refere-se a uma revisão de literatura sobre o vírus HPV e câncer de colo de útero, com o objetivo de levantar aspectos da infecção do vírus que influenciam no curso natural do câncer de colo de útero tais como: a tipologia do vírus, a duração e a persistência da infecção além de associar com as manifestações das lesões precursoras até a evolução da neoplasia. Foi possível constatar a forte associação da infecção com a evolução da neoplasia cervical, no entanto, ainda são necessários estudos que elucidem melhor certos aspectos da infecção do vírus HPV que agem sobre o colo do útero para que as ações de prevenção e combate a doença sejam mais eficazes.Este artículo se refiere a una revisión de literatura sobre el virus HPV y la neoplasia cervical, con el objetivo de levantar aspectos de la infección del virus que influye en el curso natural del cáncer de cuello del útero tales como: la tipologia del virus, la duración y la persistencia de la infección además de asociarlo a las manifestaciones de las lesiones precursoras hasta la evolución de la neoplasia. Ha sido posible constatar la fuerte asosiación de la infección con la evolución de la neoplasia cervical, entretanto, aún son necesarios estudios que eluciden mejor ciertos aspectos de la infección del virus HPV que actúa sobre el cuello del útero para que las acciones de prevención y combate a la enfermedad sean más eficaces.This article refers to a review of literature about the HPV virus and the cervical neoplasia, aiming at raising aspects of the virus infection which influences in the natural development of the uterine cervical cancer such as: the type of virus, the duration and the persistence of the infection and also the association with the manifestations of the preceding lesions up to the evolution of the neoplasia. It was possible to notice the strong association of the infection with the evolution of the cervical neoplasia, however, studies to better elucidate certain aspects of the infection of the HPV virus that acts on the uterine cervix are still necessary so that the actions of prevention and fight against the disease will be more efficient.

Janete Tamani Tomiyoshi Nakagawa; Janine Schirmer; Márcia Barbieri

2010-01-01

154

Vírus HPV e câncer de colo de útero/ Human Papillomavirus (HPV) and uterine cervical cancer/ Virus HPV y el cáncer del cuello uterino  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Este artigo refere-se a uma revisão de literatura sobre o vírus HPV e câncer de colo de útero, com o objetivo de levantar aspectos da infecção do vírus que influenciam no curso natural do câncer de colo de útero tais como: a tipologia do vírus, a duração e a persistência da infecção além de associar com as manifestações das lesões precursoras até a evolução da neoplasia. Foi possível constatar a forte associação da infecção com a evolução da n (more) eoplasia cervical, no entanto, ainda são necessários estudos que elucidem melhor certos aspectos da infecção do vírus HPV que agem sobre o colo do útero para que as ações de prevenção e combate a doença sejam mais eficazes. Abstract in spanish Este artículo se refiere a una revisión de literatura sobre el virus HPV y la neoplasia cervical, con el objetivo de levantar aspectos de la infección del virus que influye en el curso natural del cáncer de cuello del útero tales como: la tipologia del virus, la duración y la persistencia de la infección además de asociarlo a las manifestaciones de las lesiones precursoras hasta la evolución de la neoplasia. Ha sido posible constatar la fuerte asosiación de la i (more) nfección con la evolución de la neoplasia cervical, entretanto, aún son necesarios estudios que eluciden mejor ciertos aspectos de la infección del virus HPV que actúa sobre el cuello del útero para que las acciones de prevención y combate a la enfermedad sean más eficaces. Abstract in english This article refers to a review of literature about the HPV virus and the cervical neoplasia, aiming at raising aspects of the virus infection which influences in the natural development of the uterine cervical cancer such as: the type of virus, the duration and the persistence of the infection and also the association with the manifestations of the preceding lesions up to the evolution of the neoplasia. It was possible to notice the strong association of the infection wi (more) th the evolution of the cervical neoplasia, however, studies to better elucidate certain aspects of the infection of the HPV virus that acts on the uterine cervix are still necessary so that the actions of prevention and fight against the disease will be more efficient.

Nakagawa, Janete Tamani Tomiyoshi; Schirmer, Janine; Barbieri, Márcia

2010-04-01

155

Therapeutic comparison of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages I b2-II a cervical cancer  

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Objective: To compare the short-term and long-term therapeutic response of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages I b2-II a cervical cancer. Methods: One hundred and fifty-one patients with stages I b2-II a cervical cancer were treated with preoperative intra-arterial chemotherapy before radical hysterectomy was carried out. Patients in study group (n = 113) received uterine artery chemoembolization (UACE), while patients control group(n = 38) received internal iliac anterior trunk arterial chemotherapy. Radical hysterectomy was carried out in all patients within 2-4 weeks after UACE or chemotherapy. The tumor size was measured before and after the procedure,and the survival rate at 2 and 5 years after treatment was calculated. Results: The mean maximum diameter of the tumors was (4.58 ± 0.37) cm before interventional therapy, and it was (2.11 ± 0.24) cm in two weeks after interventional therapy. The complete response rate of study group and control group was 31.9% and 21.1% respectively. The total effective rate of study group and control group was 94.7% (107/113) and 76.3% (29/38) respectively. The effective rate of study group two weeks after therapy was significantly higher than that of control group. No surgical margin infiltration was observed in both groups. Pathological findings in study group included vascular invasion around surgical margin (n = 3), parametrial invasion (n = 5) and pelvic lymph node metastasis (n = 6), while in control group vascular invasion around surgical margin, parametrial invasion and pelvic lymph node metastasis were found in one, two and one cases respectively. The two-year and five-year survival rate in study group were 80.9% (68/84) and 73.4% (47/64) respectively, while the two-year and five-year survival rate in control group were 81.3% (26/32) and 75.0% (18/24) respectively. No significant difference in survival rate existed between two groups. Conclusion: Uterine artery chemoembolization can markedly reduce the volume of cervical cancer,which is very helpful for surgical resection. The therapeutic effectiveness of UACE is superior to internal iliac anterior trunk arterial chemotherapy, therefore, UACE should be regarded as neo-adjuvant intra-arterial chemotherapy of first choice for patients with stages I b2-II a cervical cancer. (authors)

2010-01-01

156

Immunolabelling of the inhibin/activin-?C subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines.  

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Inhibins are dimeric glycoproteins, composed of an ?-subunit and one of two possible ?-subunits (?A or ?B), with substantial roles in human reproduction and in endocrine-responsive tumours. Recently a novel ? subunit named ?C was described, although it is still unclear if normal or cancerous cervical epithelial cells as well as cervical cancer cell lines can synthesise the inhibin-?C subunit. Four normal cervical tissue samples together with specimens of well-differentiated squamous cervical cancer and adenocarcinoma of the cervix were immunohistochemically analyzed. Additionally, two cervical carcinoma cell lines (HeLa and CaSKi) were analyzed by immunofluorescence for the expression of this novel subunit. We demonstrated for the first time an immunolabelling of the inhibin-?C subunit in normal and malignant cervical tissue, as well as cervical cancer cells. Although the physiological role is still unclear in cervical tissue, the inhibin-?C subunit might play important roles in carcinogenesis. Moreover, the synthesis of this subunit in cervical carcinoma cell lines of squamous and epithelial origins allows the use of these cell lines in elucidating its functions in cervical pathogenesis. PMID:21109970

Blankenstein, Thomas; Jückstock, Julia; Shabani, Naim; Kunze, Susanne; Brüning, Ansgar; Bergauer, Florian; Mylonas, Ioannis

2011-01-01

157

Immunolabelling of the inhibin/activin-?C subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines.  

UK PubMed Central (United Kingdom)

Inhibins are dimeric glycoproteins, composed of an ?-subunit and one of two possible ?-subunits (?A or ?B), with substantial roles in human reproduction and in endocrine-responsive tumours. Recently a novel ? subunit named ?C was described, although it is still unclear if normal or cancerous cervical epithelial cells as well as cervical cancer cell lines can synthesise the inhibin-?C subunit. Four normal cervical tissue samples together with specimens of well-differentiated squamous cervical cancer and adenocarcinoma of the cervix were immunohistochemically analyzed. Additionally, two cervical carcinoma cell lines (HeLa and CaSKi) were analyzed by immunofluorescence for the expression of this novel subunit. We demonstrated for the first time an immunolabelling of the inhibin-?C subunit in normal and malignant cervical tissue, as well as cervical cancer cells. Although the physiological role is still unclear in cervical tissue, the inhibin-?C subunit might play important roles in carcinogenesis. Moreover, the synthesis of this subunit in cervical carcinoma cell lines of squamous and epithelial origins allows the use of these cell lines in elucidating its functions in cervical pathogenesis.

Blankenstein T; Jückstock J; Shabani N; Kunze S; Brüning A; Bergauer F; Mylonas I

2011-01-01

158

EVALUATION OF P16INK4A PROTEIN AS A BIOMARKER FOR CERVICAL INTRAEPITHELIAL NEOPLASIA AND SQUAMOUS CELL CARCINOMA OF THE UTERINE CERVIX  

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Full Text Available The association of human papilloma virus (HPV) infection and cervical intraepithelial neoplasia (CIN) is well known. Interaction of HPV proteins with cellular regulatory proteins leads to up regulation of p16INK4A. The aim of this study was to evaluate p16INK4A protein as a biomarker for CIN lesions and squamous cell carcinoma on biopsy specimens of patients who underwent biopsy of the uterine cervix due to abnormal cytological finding.The authors analyzed biopsies from 50 patients with CIN and invasive squamous cell carcinoma of the uterine cervix. Expression of p16INK4A in CIN and invasive squamous cell carcinoma was immunohistochemically analyzed by using monoclonal anti-p16INK4A antibody.A total of 50 patients with CIN and invasive squamous cell carcinoma of the uterine cervix (mean age 40.2±11.5 years, range 20-74 years) were analyzed. CIN I lesions were found in 27 (54%), CIN II/CIN III lesions in 9 (18%), and invasive squamous cell carcinoma in 14 (28%) patients. Differences in the expression of p16INK4A between CIN I, CIN II/CIN III and squamous cell carcinoma were statistically significant (p<0.0001). Expression of p16INK4A showed low sensitivity (7%), specificity (8%), positive predictive value (8%), and negative predictive value (7%) for CIN I. Sensitivity, specificity, positive predictive value, and negative predictive value of p16INK4A were 78%, 61%, 30%, and 93% for CIN II/CIN III, and 100%, 75%, 61%, and 100% for squamous cell carcinoma, respectively.Results of this study suggest that p16INK4A protein may be a sensitive biomarker for CIN II/CIN III lesions and invasive squamous cell carcinoma of the uterine cervix.

Biljana ?or?evi?; Nikola Živkovi?

2011-01-01

159

[Prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and factors associated with non-participation in screening].  

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The objective of the study was to determine the self-reported prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and to analyze factors associated with non-participation in screening. A population-based cross-sectional study with a sample of 772 women 18 to 69 years of age and living in Rio Branco was conducted in 2007 and 2008. Data were analyzed with Stata 10.0, and prevalence rates were estimated with Poisson multivariate regression (95%CI). 85.3% of women reported at least one cervical cancer screening test in the previous three years. The majority of women (72.8%) were screened in the Brazilian Unified National Health System. After adjusting for selected variables, statistically significant prevalence rates for absence of screening were found in women 18-24 and 60-69 years of age, single, and with low income and low schooling. The prevalence rates were consistent with findings from other studies, highlighting the need for greater intervention in the group of women most vulnerable to cervical cancer incidence and mortality. PMID:22666819

Borges, Maria Fernanda de Sousa Oliveira; Dotto, Leila Maria Geromel; Koifman, Rosalina Jorge; Cunha, Margarida de Aquino; Muniz, Pascoal Torres

2012-06-01

160

[Prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and factors associated with non-participation in screening].  

UK PubMed Central (United Kingdom)

The objective of the study was to determine the self-reported prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and to analyze factors associated with non-participation in screening. A population-based cross-sectional study with a sample of 772 women 18 to 69 years of age and living in Rio Branco was conducted in 2007 and 2008. Data were analyzed with Stata 10.0, and prevalence rates were estimated with Poisson multivariate regression (95%CI). 85.3% of women reported at least one cervical cancer screening test in the previous three years. The majority of women (72.8%) were screened in the Brazilian Unified National Health System. After adjusting for selected variables, statistically significant prevalence rates for absence of screening were found in women 18-24 and 60-69 years of age, single, and with low income and low schooling. The prevalence rates were consistent with findings from other studies, highlighting the need for greater intervention in the group of women most vulnerable to cervical cancer incidence and mortality.

Borges MF; Dotto LM; Koifman RJ; Cunha Mde A; Muniz PT

2012-06-01

 
 
 
 
161

Análisis de expresión global del cáncer cérvico uterino: rutas metabólicas y genes alterados/ Global expression analysis in uterine cervical cancer: Metabolic pathways and altered genes  

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Full Text Available Abstract in spanish La infección por virus de papiloma de alto riesgo (VPH) es considerada como el factor etiológico más importante del cáncer cérvico uterino (CaCU). Con el fin de determinar el patrón de expresión global e identificar algunos posibles genes marcadores del CaCU, se utilizaron microhileras de DNA que contenían 8,000 secuencias que codificaban para transcritos diferentes, para estudiar los perfiles de expresión de cinco líneas celulares derivadas de CaCU, tres muestr (more) as tumorales conteniendo VPH 16 y tres muestras normales negativas para la presencia de VPH. Se identificaron los niveles de expresión de genes relacionados con diferentes rutas metabólicas. Se llevó a cabo el análisis de agrupamiento jerárquico y posteriormente se confirmó la sobrexpresión de dos genes mediante RT-PCR. Estos dos genes se encontraron sobrexpresados en biopsias tumorales cervicales. Uno de ellos, el gen de IL6, que ha sido previamente reportado en relación con CaCU, así como el gen de la matriz-metaloproteasa 10 (MMP10) por primera vez relacionado con esta neoplasia. El análisis de agrupamiento jerárquico, además, reveló que las muestras que contienen el mismo tipo viral están asociadas, sugiriendo posibles diferencias en expresión entre tipos virales. Abstract in english High risk human papillomavirus (HPV) infection is considered to be the most important etiological factor of Cervical Uterine Cancer. In order to determine the global expression pattern and to identify possible molecular markers of cervical cancer, cDNA arrays with probe sets complementary to 8,000 human genes were used to examine the expression profiles among 5 cell lines derived from human cervical cancer, three HPV16(+) tumor samples and three normal cervical tissues HP (more) V(-). The levels of expression of different cellular processes were identified. Hierarchical clustering was performed and the gene expression using RT-PCR was confirmed. Two genes were found to be consistently overexpressed in invasive cervical cancer biopsies; one of them, IL-6 was previously reported to be overexpressed in cervical cancer and one novel gene, MMP10, previously not known to be related to cervical cancer. Hierarchical clustering of the expression data revealed that samples with common HPV type infection grouped together, maybe this could mean that differences between HPV types could be indirectly determined by expression profiles.

Vázquez-Ortíz, Guelaguetza; Piña-Sanchez, Patricia; Hidalgo, Alfredo; Lazos, Minerva; Moreno, José; Alvarado, Isabel; Cruz, Fernando; Hernández, Dulce M; Pérez-Plascencia, Carlos; Salcedo, Mauricio

2005-06-01

162

Simultaneous detection of antigens and specific DNA sequences of human papillomavirus in uterine cervical biopsy specimens. Description of a double-labelling technique.  

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We studied 70 uterine cervical biopsy specimens with a histological diagnosis compatible with human papillomavirus (HPV) infection. We carried out immunohistochemical and in situ hybridization techniques and selected 22 specimens that had given a positive result with both techniques. We then used a double-labelling technique (a combination of immunohisto-chemistry and in situ hybridization) to detect simultaneously viral antigens and specific gene sequences of HPV. With this technique we found three different cell types in the tissue: (1) cells with black nuclei, positive by immunohisto-chemistry and in situ hybridization; (2) cells with red nuclei, negative by immunohistochemistry and positive by in situ hybridization; and (3) cells with light blue nuclei, negative by both techniques. In this study we describe this technique; and we believe that the simultaneous detection of viral antigens and specific gene sequences of HPV may be very useful in the study of the virus-cell interaction.

Gómez F; Roldán M; Corcuera MT; Picazo A; Muñoz E; Alonso MJ

1997-01-01

163

Adjuvant radiotherapy following radical hysterectomy and bilateral pelvic lymph node dissection for the uterine cervical cancer: prognostic factors and failure patterns  

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To identify variable prognostic factors and analyse failure patterns in the uterine cervix cancer after radical operation and adjuvant radiotherapy, a retrospective analysis was undertaken. I analysed one hundred and twenty four patients with uterine cervix cancer, FIGO stage IB, IIA and IIB, treated with radical hysterectomy and pelvic lymph node dissection followed by adjuvant radiotherapy between May 1985 and May 1994. Minimum follow up period was 24 months. All of them were treated with full dose external radiotherapy with linear accelerator and/or high dose rate intracavitary radiation. Overall 5 year survival rate and relapse free survival rate were 75.4%, 73.5%, respectively. Significant prognostic factors by relapse free survival were wall involvement thickness, lymph node location and number, parametrium involvement, tumor size, stage, uterine body involvement, vaginal resection margin involvement. By multivariate analysis, lymph node metastasis, tumor size and vaginal resection margin involvement were significant prognostic factors. Treatment related failure were 33 cases. Locoregional failure were more likely in the stage IIB, lymph node positive or vaginal resection margin positive patients whereas distant failures were relatively more frequent in stage IB, IIA and lymph node, vaginal resection negative patients. In stage IIB, 5 year relapse free survival rate was only 56% and nine of twenty two patients recurred. Postoperative radiotherapy results are good for patients with relatively low risk factor. But the results are poor for patients with multiple, high risk factors or stage IIB. To control recurrence for patients with high risk factors, postoperative adjuvant radiotherapy is not sufficient treatment method. To raise control rate, adding other methods such as radiosensitizing agent or chemotherapy is necessary and prospectively randomized study is needed for evaluation of postoperative radiotherapy efficacy and/or other methods. And it is reasonable to treat primary radical radiotherapy for patients with stage IIB cervical cancer instead of radical operation and adjuvant radiotherapy and/or chemotherapy regimen. (author).

Choi, D. H. [Soonchunhyang University Hospital, Seoul (Korea, Republic of)

1997-12-01

164

Adjuvant radiotherapy following radical hysterectomy and bilateral pelvic lymph node dissection for the uterine cervical cancer: prognostic factors and failure patterns  

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To identify variable prognostic factors and analyse failure patterns in the uterine cervix cancer after radical operation and adjuvant radiotherapy, a retrospective analysis was undertaken. I analysed one hundred and twenty four patients with uterine cervix cancer, FIGO stage IB, IIA and IIB, treated with radical hysterectomy and pelvic lymph node dissection followed by adjuvant radiotherapy between May 1985 and May 1994. Minimum follow up period was 24 months. All of them were treated with full dose external radiotherapy with linear accelerator and/or high dose rate intracavitary radiation. Overall 5 year survival rate and relapse free survival rate were 75.4%, 73.5%, respectively. Significant prognostic factors by relapse free survival were wall involvement thickness, lymph node location and number, parametrium involvement, tumor size, stage, uterine body involvement, vaginal resection margin involvement. By multivariate analysis, lymph node metastasis, tumor size and vaginal resection margin involvement were significant prognostic factors. Treatment related failure were 33 cases. Locoregional failure were more likely in the stage IIB, lymph node positive or vaginal resection margin positive patients whereas distant failures were relatively more frequent in stage IB, IIA and lymph node, vaginal resection negative patients. In stage IIB, 5 year relapse free survival rate was only 56% and nine of twenty two patients recurred. Postoperative radiotherapy results are good for patients with relatively low risk factor. But the results are poor for patients with multiple, high risk factors or stage IIB. To control recurrence for patients with high risk factors, postoperative adjuvant radiotherapy is not sufficient treatment method. To raise control rate, adding other methods such as radiosensitizing agent or chemotherapy is necessary and prospectively randomized study is needed for evaluation of postoperative radiotherapy efficacy and/or other methods. And it is reasonable to treat primary radical radiotherapy for patients with stage IIB cervical cancer instead of radical operation and adjuvant radiotherapy and/or chemotherapy regimen. (author).

1997-01-01

165

Detection of apoptosis and expression of apoptosis-associated proteins as early predictors of prognosis after irradiation therapy in stage IIIb uterine cervical cancer  

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We investigated the proportion of apoptotic cells and the expression of apoptosis-associated proteins after the delivery of the first week of irradiation for stage IIIb uterine cervical cancer. Thirty patients with stage IIIb squamous cell carcinoma of the uterine cervix who received only irradiation therapy were registered in this study. Specimens were obtained before irradiation therapy and at the end of the first week of irradiation. The apoptotic index (AI) of each tissue specimen was calculated by counting the apoptotic cells and expressed as a percentage. Immunohistochemical evaluation for apoptosis-related proteins, p53, Bcl-2, Bax, caspase-1 and caspase-3 was also performed. The AI was 0.8{+-}0.9% (mean{+-}SD) before irradiation and 1.7{+-}1.3% at the end of the first week of irradiation. We observed that the patients who survived more than 5 years had AI levels of 2.1{+-}1.3% at the end of their first week of therapy. This rate was significantly higher than the rate of 1.1{+-}0.8% (P=0.02) of the patients who died within 5 years. When the cut-off value of the AI was set at 1.7%, the sensitivity, specificity, positive predictive value, and negative predictive value for the prediction of patients' prognosis after irradiation therapy were 73.4%, 72.4%, 82.4%, and 61.5%, respectively. In 17 of the AI-positive cases, expressions of Bax (P=0.006), caspase-1 (P=0.045), and caspase-3 (P=0.013) at the end of the first week were significantly higher than before irradiation. The proportion of apoptotic cells and the expression of apoptosis-associated proteins, Bax, caspase-1, and caspase-3, at the end of the first week of irradiation could be useful predictors of the prognosis in stage IIIb squamous cell carcinoma of the uterine cervix treated by irradiation therapy. (author)

Yuki, Hiroyoshi [Tonami General Hospital, Toyama (Japan); Fujimura, Masaki; Yamakawa, Yoshihiro; Hidaka, Takao; Saito, Shigeru

2000-01-01

166

Detection of apoptosis and expression of apoptosis-associated proteins as early predictors of prognosis after irradiation therapy in stage IIIb uterine cervical cancer  

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[en] We investigated the proportion of apoptotic cells and the expression of apoptosis-associated proteins after the delivery of the first week of irradiation for stage IIIb uterine cervical cancer. Thirty patients with stage IIIb squamous cell carcinoma of the uterine cervix who received only irradiation therapy were registered in this study. Specimens were obtained before irradiation therapy and at the end of the first week of irradiation. The apoptotic index (AI) of each tissue specimen was calculated by counting the apoptotic cells and expressed as a percentage. Immunohistochemical evaluation for apoptosis-related proteins, p53, Bcl-2, Bax, caspase-1 and caspase-3 was also performed. The AI was 0.8±0.9% (mean±SD) before irradiation and 1.7±1.3% at the end of the first week of irradiation. We observed that the patients who survived more than 5 years had AI levels of 2.1±1.3% at the end of their first week of therapy. This rate was significantly higher than the rate of 1.1±0.8% (P=0.02) of the patients who died within 5 years. When the cut-off value of the AI was set at 1.7%, the sensitivity, specificity, positive predictive value, and negative predictive value for the prediction of patients' prognosis after irradiation therapy were 73.4%, 72.4%, 82.4%, and 61.5%, respectively. In 17 of the AI-positive cases, expressions of Bax (P=0.006), caspase-1 (P=0.045), and caspase-3 (P=0.013) at the end of the first week were significantly higher than before irradiation. The proportion of apoptotic cells and the expression of apoptosis-associated proteins, Bax, caspase-1, and caspase-3, at the end of the first week of irradiation could be useful predictors of the prognosis in stage IIIb squamous cell carcinoma of the uterine cervix treated by irradiation therapy. (author)

2000-01-01

167

Vesico-uterine fistula.  

UK PubMed Central (United Kingdom)

Nine cases of vesico-uterine fistula caused by injury to the bladder at Caesarean section or by rupture of the uterus and bladder following obstructed labour are described. Symptoms depend on the level of the lesion, menstruation into the bladder and menouria occurring when the fistula is above the internal cervical os: whatever the level, most patients with vesico-uterine fistula present with incontinence of urine. A transperitoneal approach appears to give better results than a transvesical repair.

Iloabachie GC; Njoku O

1985-08-01

168

Expression of mitotic-arrest deficiency 2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer  

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We previously reported satisfactory therapeutic results when using cisplatin-based cyclic balloon-occluded arterial infusion chemotherapy as neoadjuvant chemotherapy (NAC), which enabled hysterectomy to be performed for patients with locally advanced cervical cancer. Mitotic arrest deficiency 2 (MAD...

MORISHITA, MASANARI; SUMI, TOSHIYUKI; NAKANO, YUSUKE; TERAMAE, MASATOMO; FUKUDA, TAKESHI; NOBEYAMA, HIROYUKI; YOSHIDA, HIROYUKI

169

TRANSABDOMINAL EVALUATION OF UTERINE CERVICAL LENGTH DURING PREGNANCY FAILS TO IDENTIFY A SUBSTANTIAL NUMBER OF WOMEN WITH A SHORT CERVIX  

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Objective To assess the diagnostic performance of transabdominal sonographic measurement of cervical length in identifying patients with a short cervix. Methods Cervical length was measured in 220 pregnant women using transabdominal and transvaginal ultrasound (US). Reproducibility and agreement between and within both methods were assessed. The diagnostic accuracy of transabdominal US for identifying cases with a cervical length <25mm was evaluated. Results Twenty-one out of 220 cases (9.5%) had a cervical length <25mm by transvaginal US. Only 43% (n=9) of patients with a short cervix were correctly identified by transabdominal US. In patients with a cervical length of <25mm by transvaginal US, transabdominal measurement of the cervix overestimated this parameter by an average of 8mm (95% LOAs: ?26.4 to 10.5mm). Among women without a short cervix, transabdominal US underestimated cervical length on average (LOA) by 1.1mm (95% LOAs: ?11.0 to 13.2mm). Transvaginal US was also more reproducible (intraclass correlation coefficient: (ICC: 0.96; 95% CI: 0.94 to 0.97) based on comparisons between 2D images and immediately acquired 3D volume datasets relative to transabdominal US (ICC: 0.71; 95% CI: 0.57 to 0.84). Transvaginal US detected 13 cases with funneling and 6 cases with sludge whereas only 3 cases of funneling and one of sludge were detected by transabdominal US. Conclusion Transabdominal measurement overestimated cervical LOA by 8mm among women with a short cervix and resulted in the underdiagnosis of 57% of cases.

Hernandez-Andrade, Edgar; Romero, Roberto; Ahn, Hyunyoung; Hussein, Youssef; Yeo, Lami; Korzeniewski, Steven J.; Chaiworapongsa, Tinnakorn; Hassan, Sonia S

2012-01-01

170

Conocimientos sobre prevención del cáncer cérvico-uterino en los adolescentes Knowledge on the prevention of the cervical-uterine cancer in the adolescents  

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Full Text Available En Cuba, al igual que en el resto de los países occidentales, el cáncer cérvico-uterino se encuentra en segundo lugar de morbilidad oncológica en mujeres de 20 a 30 años; y a ctualmente está considerado como una infección de transmisión sexual. Hay estudios que revelan información deficiente por parte de los adolescentes en cuanto a las infecciones de transmisión sexual y sus consecuencias. Es por ello, que en el período comprendido entre febrero y noviembre de 2009 se realizó una investigación descriptiva con el objetivo de identificar los conocimientos sobre prevención del cáncer cérvico-uterino en los adolescentes de la ESBU Manuel Sanguily, del municipio Matanzas. El universo estuvo integrado por los alumnos de noveno grado, y para la selección de la muestra se utilizó un muestreo probabilístico por conglomerados monoetápico. Se aplicó un cuestionario, cuyos resultados relevantes indicaron que los varones iniciaron sus primeras relaciones sexuales a los 13 años y las hembras a las edades de 13 y 14 años, representado un 57,1 % y 50 %, respectivamente. Solo el 12,7 % de los adolescentes identificó al virus del papiloma humano como factor de riesgo en la génesis del cáncer cérvico-uterino. El bajo nivel de conocimientos para la prevención de este tipo de cáncer predominó en el 92,7 % de la muestra. Se concluye que en el grupo de adolescentes estudiados, lo más frecuente fue el inicio temprano de las relaciones sexuales, tanto para varones como para hembras, aunque estas últimas representaron solo el 10 %. Se identificó desconocimiento sobre el virus del papiloma humano como agente causal de esta morbilidad, y pobre conocimiento sobre cómo prevenirlo.In Cuba, as in the rest of the Western countries, the cervical-uterine cancer is in the second place of oncologic morbidity in 20-to-30 years-old women; currently it is considered a sexually transmitted infection. There are some studies revealing deficient information on the part of the teenagers as for the sexually transmitted diseases and theirs consequences. That is why, in the period from February to November 2009 we carried out a descriptive investigation with the objective of identifying the knowledge on the prevention of the cervical-uterine cancer the students of the Secondary School Manuel Sanguily, Municipality of Matanzas, have. The universe was formed by the nine grade students, and to select the sample we used a probabilistic sampling by mono-stage conglomerates. A questionnaire was applied and the results indicated that the males began their first sexual relationships to the 13 years and the females to the ages of 13 and 14 years, representing 57,1 % and 50 %, respectively. Only 12,7 % of the teenagers identified the human papilloma virus as a risk factor in the genesis of the cervical-uterine cancer. The low level of knowledge for the prevention of this kind of cancer prevailed in 92,7 % of the sample. We concluded that in the group of teenagers we studied, the most frequent fact was that they began early having sexual relationships, both boys and girls, although the last ones represented only 10 %. We identified ignorance on the human papilloma virus and poor knowledge about how to prevent it as the casual agent of this morbidity.

Regla Mercedes García Rosique; Adelaida Torres Triana; Marlén Rendón Quintero

2011-01-01

171

[Participation in the Dutch national screening programme for uterine cervic cancer higher after invitation by a general practitioner, especially in groups with a traditional low level of attendance  

UK PubMed Central (United Kingdom)

OBJECTIVE: To gain insight into the differences in participation in the screening programme for uterine cervix cancer between women invited by a general practitioner (GP) and women invited by the local health authority (GGD). Specific attention was given to those groups whose participation is generally below average. DESIGN: Descriptive epidemiological study. METHOD: In the period 2000-2003, 237,719 women (30-60 years of age) were invited to participate in the national uterine cervix cancer screening programme in the Southwest of the Netherlands; 37.1% of the women were invited by the GP and 62.9% by the GGD. Data were obtained from the Cervix Information System of the GGDs. Differences in attendance between those invited by the GP and those invited by the GGD were tested by linear regression. Participation was defined as the number of women for whom the result of a cervical smear was known, divided by the number invited. RESULTS: Invitation by a GP led to a 7.9% (95% CI: 7.5-8.3) higher attendance rate than invitation by a GGD. This difference in attendance was higher for women born in Morocco, Turkey, Surinam and the Netherlands Antilles/Aruba (17.2%; 95% CI: 15.2-I9.2), young women (11.9%; 95% CI: 10.8-13.0), women with a low socio-economic status (11.6%; 95% CI: 10.4-12.7), and women who lived in highly urban areas (13.0%; 95% CI: 12.3-13.6). The differences were the greatest among non-western women who were also part of another low-attendance group: 19.0% (95% CI: 16.7-21.2) for women who lived in highly urban areas and 20.8% (95% CI: 16.8-24.9) for those in the youngest age group.

de Nooijer DP; de Waart FG; van Leeuwen AW; Spijker WW

2005-10-01

172

[Cervical pregnancy: conservative treatment with primary embolization of the uterine arteries. A case report. Review of the literature].  

Science.gov (United States)

Ectopic pregnancies are rarely located in the cervix. In most (50-70%) of the cases, haemostatic hysterectomy is usually performed. We attempted an original approach for ectopic pregnancies located in the cervix which allowed preservation of the uterus. The uterine arteries are embolized before evacuation of the pregnancy and haemostasis of the loge with a balloon probe. In the literature, the incidence has been reported at 1 cases/20,000 births. Past history of curetage is a favouring factor. Echography facilitates diagnosis. When possible, conservative treatment may involve surgery (arterial ligature, endocervical haemostasis), drug therapy (methotrexate) and radiography (arterial embolization). PMID:7730566

Lambert, P; Marpeau, L; Jannet, D; Jault, T; Truchet, F; Safar, E; Rotenberg, L; Pathier, D; Milliez, J

1995-01-01

173

Protein p 16INK4A expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of uterine cervix  

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Full Text Available The association of human papilloma virus (HPV) infection and cervical intraepithelial neoplasia (CIN) is well recognized. Interaction of HPV oncogenic proteins with cellular regulatory proteins leads to up regulation of p16 INK4A , a CDK inhibitor, which is a biomarker for HPV infection. We investigated p16 expression in CIN and invasive squamous cell carcinoma (SCC) which has not been reported in the Indian population previously. Materials and Methods: Retrospective analysis of 100 cases with 20 cases each of histologically normal cervical epithelium, CIN1, 2, 3 and invasive SCC for p16 expression was performed by immunohistochemistry using commercially available mouse monoclonal antibody to p16 (clone 6H12). Statistical Analysis: For differences in expression among groups, statistical analysis was carried out using ANOVA and post hoc test of Scheffe. Results: p16 immunoreactivity was found to be both nuclear and/or cytoplasmic. The normal cervical epithelium was predominantly negative for p16 (18/20). There was a progressive increase of p16 expression with the grade of CIN. In CIN 1, two cases (20%) showed nuclear and nucleocytoplasmic positivity respectively. In contrast, diffuse strong nuclear or nucleocytoplasmic expression was observed in 45 and 55% cases of CIN 2 and CIN 3 respectively. All except one squamous cell carcinoma stained strongly positive for p16. The difference in expression between CIN 2/3 and SCC versus normal cervix was found highly significant (p is equal to 0.008 and p less than 0.001). Conclusions: p16 expression correlates excellently with the grade of CIN and is a sensitive marker of cervical intraepithelial neoplasia.

Gupta Ruchi; Srinivasan Radhika; Nijhawan Raje; Suri Vanita; Uppal Radha

2010-01-01

174

Pelvic lymph node invasion in cervical cancer; L`envahissement ganglionnaire pelvien dans les cancers du col uterin  

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Pelvic lymph node invasion is an important prognostic factor for cervical cancer. It is generally accepted that iliac lymph nodes must be treated systematically, but the extent of lymph node dissections is open to discussion. One hundred and eighty two cases of cervical cancer with lymph node invasion were treated at the Institut Curie between 1960 and 1988, by colpophysterectomy with lymph node dissection (168 cases) combined with preoperative brachytherapy and, in some cases, pre- and/or postoperative radiotherapy; in 14 cases, only an exploratory operation was performed. External iliac lymph node invasion was found in 95% of cases, situated in the middle and internal chains. Common iliac lymph node invasion was found in 24% of cases, but was only exceptionally isolated (3%). It is therefore possible, by means of well defined, localized external iliac dissection, with frozen section histological examination, to determine the exact lymph node status. Lumboaortic lymph node invasion was found in 8.2% of cases. The overall survival rate was 49% at 5 years and 40.5% at 10 years. Factors which influence survival are: the cervical volume (p = 0.015), the unilateral or bilateral nature of invasion (p = 0.0015), the number of lymph nodes invaded (two or more than two) (p = 0.0001), capsular rupture (p = 0.0008), lymph node adhesions other than venous (p = 0.0002), common iliac invasion (p 0.0001). On Cox`s model, the principal factors were the number of lymph nodes invaded, adhesion other than venous, common iliac invasion; on the other hand, venous adhesion does not modify the prognosis. The five-year survival rates following external iliac dissections and complete pelvic dissections were not significantly different. Finally, postoperative radiotherapy ensured a higher five-year survival rate than preoperative radiotherapy, but the cervical volume was greater and primary invasion was more frequent in these cases. (Abstract Truncated)

Renolleau, C.; Laroussinie, M.P.; Mosseri, V.; Fenton, J.; De la Rochefordiere, A.; Clough, K.B.; Hamelin, J.P.; Durand, J.C. [Institut Curie, 75 - Paris (France)

1995-12-31

175

A case report of anal cancer preceded by perianal Paget's disease after irradiation for uterine cervical cancer and review of perianal Paget's disease in Japan  

International Nuclear Information System (INIS)

The patient was a 59-year-old woman. Total hysterectomy and irradiation were performed for uterine cervical cancer 25 year previously. Paget's cells resembling signet ring cells were found in the epidermis, and anal cancer was present adjacent to them. The histological diagnosis of the anal cancer was mainly well differentiated adenocarcinoma, but mucinous carcinoma was present containing signet ring cells at sites contiguous with the anal glands, and lymphatic permeation was noted in the dermis. The cancer and the Paget's cells were both positive for PAS and alcian blue staining and were negative for PB/KOH/PAS staining. Furthermore, such findings as atypia of the glandular ducts and endoarteritis were detected in the underlying mucosa. Therefore, it was considered that this patient had anal cancer derived from the anal glands, that the Paget's cells were due to the intraepidermal extension of signet ring cells, and that the cancer may have been related to her previous irradiation. Reports of cancer of the rectum and anus complicated by Paget's lesion in Japan were reviewed and studied with regard to the histogenesis. It was concluded that peri-anal Paget's lesion had a close relationship with anal cancer derived from the anal glands. (author)

1991-01-01

176

Radiotherapy quality assurance of the Japanese Gynecologic Oncology Group study (JGOG1066): a cooperative phase II study of concurrent chemoradiotherapy for uterine cervical cancer.  

UK PubMed Central (United Kingdom)

BACKGROUND: To assess radiotherapy protocol compliance in a multi-institutional phase II study of concurrent chemoradiotherapy for patients with locally advanced cancer of the uterine cervix (JGOG1066). METHODS: For study protocol development, various radiotherapy parameters were examined and consensus was reached by Japanese radiation oncologists with cervical cancer treatment expertise. Quality assurance (QA) was also discussed and included in the protocol. A credentialing process was used to select institutions for participation in the study. Individual case reviews referring to 18 QA items were undertaken for each patient. Radiotherapy data were submitted to the Japanese Gynecologic Oncology Group (JGOG) data center and reviewed by the members of the radiotherapy committee. The QA evaluation was classed as per protocol, deviation, and violation. RESULTS: Individual case reviews were performed on 69 of 72 patients entered in the study. In 24 patients (35%), there were no deviations for any QA items. There were also no deviations seen for 5 of the 18 items in 69 patients evaluated. Deviations of 64 QA items were seen in 45 cases, and violations were seen in 4 cases (4 items). The most common deviation concerned appropriate application for the external beam radiotherapy (EBRT) boost to involved nodes or parametrium (32 cases). The 4 violations were identified in the QA items regarding high-dose rate intracavitary brachytherapy. CONCLUSIONS: Radiotherapy protocol compliance was favorable except for the EBRT boost indications. The results of this study validate the quality of radiotherapy in JGOG1066, and indicate that the final analysis will provide meaningful results.

Toita T; Kato S; Ishikura S; Tsujino K; Kodaira T; Uno T; Hatano K; Sakurai H; Niibe Y; Kazumoto T; Nishimura T; Kitagawa R; Fukutani M; Oguchi M; Umayahara K; Hirashima Y; Aoki Y; Takizawa K

2011-08-01

177

Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy; Aberracoes cromossomicas instaveis em linfocitos de pacientes com cancer de colo de utero  

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Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of {sup 69} Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

Magnata, Simey de Souza Leao Pereira

2002-09-01

178

Tendência da mortalidade por câncer do útero no Município de São Paulo entre 1980 e 1999 Mortality trends from uterine cervical cancer in the city of São Paulo from 1980 to 1999  

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Full Text Available O câncer do colo do útero apresenta grande incidência em algumas cidades brasileiras e considerável mortalidade em países em desenvolvimento, não obstante a disponibilidade já antiga de teste de rastreamento. O presente estudo visou avaliar a tendência da mortalidade por câncer de colo do útero, de corpo do útero e por câncer do útero não especificado, no Município de São Paulo, entre 1980 e 1999, por meio do exame das taxas brutas, idade-específica e ajustadas por idade. Os resultados mostraram discreta redução da mortalidade por câncer do colo do útero, queda da mortalidade por câncer de útero não especificado e aumento da mortalidade por câncer do corpo do útero. Conclui-se que a queda da mortalidade por câncer do útero não especificado sinaliza uma melhora na precisão do diagnóstico clínico e na qualidade do preenchimento do atestado de óbito, e indica aumento de cobertura do teste de Papanicolaou.Uterine cervical cancer shows a higher incidence in some Brazilian cities. It is a common cause of death in women from developing countries, despite the longstanding availability of an effective screening test, the Pap smear. This study aimed to evaluate the temporal trends of crude, age-adjusted, and age-specific mortality rates from cervical cancer, endometrial cancer, and cancer of the uterus not otherwise specified (NOS) in the city of São Paulo from 1980 to 1999. Results showed a slight reduction in cervical cancer rates, a decrease in NOS uterine cancer rates, and an increase in endometrial cancer mortality rates. The fall in mortality from NOS uterine cancer indicates an improvement in diagnostic accuracy and quality of information on death certificates and may point to an increase in coverage of cervical cancer screening using the Pap smear.

Luiz Augusto Marcondes Fonseca; Adriana de Souza Ramacciotti; José Eluf Neto

2004-01-01

179

Primary uterine cervical cancer: correlation of preoperative magnetic resonance imaging and clinical staging (FIGO) with histopathology findings.  

UK PubMed Central (United Kingdom)

The most commonly used staging system for cervical cancer is based on the International Federation of Gynaecology and Obstetrics (FIGO) staging system. Magnetic resonance imaging (MRI) has been accepted as the optimal tool for evaluation of the main prognostic factors and selection of therapeutic strategy. The purpose of this study was to compare the preoperative clinical examination FIGO staging findings with MRI and postoperative pathology report in females with primary cancer of the cervix. The study prospectively included 46 females consecutively hospitalized at the Department of Gynaecology and Obstetrics at the "Sestre milosrdnice" University Hospital Center in Zagreb. Interviews, clinical examination, transvaginal ultrasound and MRI were performed in all patients. In selected patients the surgical procedure was done and the correlation of clinical findings according to FIGO classifications, MRI and histopathological findings was completed. According to FIGO classification, positive clinical findings for stage IIA were found in 26/46 (55.5%) and stage IIB in 20/46 (44.5%)patients. FIGO MR modified classification confirmed stage IIA in 30/46 (66.6%) and stage IIB in 16/46 (33.4%) patients. Surgery (Wertheim radical hysterectomy with bilateral pelvic and selective para-aortic lymphadenectomy) was performed in 33/46 (71%) patients with clinically, MR, cytologically and pathohistologically confirmed findings of cervical cancer: 26 patients with IIA clinically FIGO stage and 7 with IIB stage. MRI examination proved better than clinical examination in staging of cervical carcinoma with 90.9% versus 79.0% accuracy rate. We suggest the application of the following MR protocol in all clinically staged FIGO IIA and IIB patients: T1W, T2WI and postcontrast dynamic T1WI after 3 and 60 seconds and after 5 minutes, performed on 1.5T MR machine.

Kraljevi? Z; Viskovi? K; Ledinsky M; Zadravec D; Grbavac I; Bilandzija M; Soljaci?-Vranes H; Kuna K; Klasni? K; Krolo I

2013-06-01

180

Mulheres vivenciando o adoecer em face do câncer cérvico-uterino Mujeres que viven la experiencia de enfermedad en la presencia de cáncer cervical-uterino Women living the experience of illness in the presence of cervical-uterine cancer  

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Full Text Available O câncer cérvico-uterino é uma doença de alta incidência e prevalência no país. Com este estudo objetivou-se compreender as vivências de mulheres em face do processo de adoecer por câncer cérvico-uterino. Estudo descritivo exploratório realizado durante o primeiro trimestre de 2002 em serviço de referência ao atendimento de neoplasias de Fortaleza-CE. Foram pesquisadas vinte mulheres com câncer cérvico-uterino mediante entrevista semi-estruturada, cujas respostas foram assim categorizadas: 1. barreiras que dificultaram a prevenção; 2. enfrentamentos: da consulta ao diagnóstico de câncer; 3. desconhecimento sobre a evolução da doença; e 4. apego às pessoas e à religiosidade. Segundo evidenciaram os resultados, a maioria era proveniente do interior do Estado, com idade entre 30 e 50 anos; 75% possuíam ensino médio; 85% viviam com um a dois salários mínimos e 45% não haviam realizado o Papanicolaou. Diante da doença, indicaram sentimentos como ansiedade, medo e pânico. Também referiram desinformação e disseram recorrer à religião como estratégia para enfrentar o câncer. Alguns fatores de risco foram mencionados, sobressaindo: ausência e não adesão ao exame preventivo, convívio com escassos recursos socioeconômicos e dificuldades de acesso aos serviços de saúde.El cáncer cervical-uterino es una enfermedad de incidencia alta y predominio en Brasil. El objetivo del estudio presente era entender qué mujeres experimentan al enfrentar el proceso de volverse la deuda enferma al cáncer cervical-uterino. Un estudio exploratorio descriptivo se llevó a cabo en el primer trimestre de 2002 a una referencia repare para el cuidado de cáncer en Fortaleza-CE. Se investigaron veinte mujeres con el cáncer cervical-uterino por medio de una entrevista semi-estructurada, con las contestaciones a categorizándose como sigue: 1. barreras que dañan la prevención; 2. cubriendo: de la visita al diagnóstico de cáncer; 3. falte de conocimiento sobre el curso de la enfermedad; y 4. la atadura a las personas y a la religiosidad. Los resultados mostraron que la mayoría de las mujeres era del interior del Estado y era 30 a 50 años viejo; 75% tenían la media educación escolar; 85% vivieron encendido a dos salario mínimo, y 45% no habían sometido a una prueba de Papanicolaou. Al enfrentar la enfermedad, ellos indicaron sentimientos de ansiedad, miedo y pánico. Ellos también informaron falta de información y declararon que ellos se repitieron a la religión como una estrategia cubrir con el cáncer. Algunos factores de riesgo fueron mencionados, el más importante entre ellos: la ausencia de un examen preventivo o falta de complacencia con él, viviendo con las personas de recursos socio-económicos escasos, y dificultad de acceso a los servicios de salud.Cervical-uterine cancer is a disease of high incidence and prevalence in Brazil. The objective of the present study was to understand what women experience when facing the process of becoming ill due to cervical-uterine cancer. A descriptive exploratory study was carried out in the first trimester of 2002 at a reference service for cancer care in Fortaleza-CE. Twenty women with cervical-uterine cancer were investigated by means of a semi-structured interview, with the responses being categorized as follows: 1. barriers that impair prevention; 2. coping: from the visit to the diagnosis of cancer; 3. lack of knowledge about the course of the disease; and 4. attachment to people and to religiosity. The results showed that most women were from the interior of the State and were 30 to 50 years old; 75% had middle school education; 85% lived on one to two minimum wages, and 45% had not submitted to a Papanicolaou test. When facing the disease, they indicated feelings of anxiety, fear and panic. They also reported lack of information and stated that they recurred to religion as a strategy to cope with cancer. Some risk factors were mentioned, the most important among them: absence of a preventive examination or lack of compliance wi

Mariza Silva de Oliveira; Ana Fátima Carvalho Fernandes; Marli Teresinha Gimeniz Galvão

2005-01-01

 
 
 
 
181

Srinagarind Hospital experience in concurrent chemoradiation for 100 patients with stage IB2 to IVA uterine cervical cancer  

International Nuclear Information System (INIS)

The aim of this study was to determine responses, acute adverse effects, and survival outcomes of women with stage IB2 to IVA treated with weekly cisplatin concurrent with pelvic irradiation at Srinagarind Hospital. The medical records of 100 women with cervical cancer stage IB2 to IVA who were treated with weekly cisplatin 40 mg/m2 concurrent with pelvic radiotherapy at Srinagarind Hospital between January 2003 and June 2006 were reviewed and analyzed. During the study period, 100 women were eligible for analysis, with a mean age of 46 years (range 24-60 years). Distribution according to International Federation of Gynecology and Obstetrics (FIGO) staging was IB2 1.0%, IIB 47.0%, IIIB 51.0%, and IVA 1.0%, respectively. A total of 86 patients received five or more cycles of weekly cisplatin. Grade 3 and 4 hematologic toxicities were found in 6.0%. The overall response rate was 97.0%. Complete response was achieved in 86 patients (86.0%) and partial response in 11 patients (11.0%). Stable disease was found in 1 patient (1.0%) but no progressive disease was found. Progression-free survival and overall survival rate were 69.6% and 96.1%, respectively. Weekly cisplatin (40 mg/m2) concurrent with pelvic irradiation for locally advanced cervical cancer was effective with acceptable toxicity in Thai women. (author)

2006-06-00

182

Postcoital bleeding due to cervical endometriosis.  

UK PubMed Central (United Kingdom)

Endometriosis of the uterine cervix is a rare lesion that is generally asymptomatic in gynaecological practice. We present a case with postcoital bleeding due to a cervical mass mimicking cervical polyp or fibroma which was histologically proven as cervical endometriosis later. Cervical endometriosis should be considered in the differential diagnosis of cervical masses with postcoital bleeding.

Seval MM; Cavkaytar S; Atak Z; Guresci S

2013-01-01

183

Computed tomography for the assessment of a pelvic lymph node metastasis in cases of a uterine cervical carcinoma  

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Seventy-six patients with cervical cancers underwent preoperative abdominopelvic computed tomography before a pelvic lymphadenectomy to evaluate the efficacy of computed tomography in assessing pelvic lymph node metastases. The sensitivity and the specificity of computed tomography for detecting pelvic lymph node metastases were judged to be 70.6 and 89.8%, respectively. In 54 patients in stage Ib or IIa of the disease, the sensitivity and specificity were 85.7 and 91.5%, respectively. Although inaccuracies could be caused by normal-sized metastasized lymph nodes and by enlarged lymph nodes with reactive hyperplasia, computed tomography was found to be a useful method of detecting a pelvic lymph node metastases. (author).

Yokoyama, Takashi; Hiura, Masamichi; Myoga, Hiroshi; Yorishima, Makoto; Tanaka, Motofumi; Chiba, Takeshi; Inatsuki, Shinichi (Shikoku Cancer Center Hospital, Matsuyama (Japan))

1990-03-01

184

Low morbidity following 9,000-rad intracavitary endocurietherapy (ECT) using the Kumar cervical applicator and external-beam radiotherapy (EXRT) in the management of carcinoma of the uterine cervix  

International Nuclear Information System (INIS)

The Kumar Cervical Applicator minimizes patient discomfort and improves patient mobility while reducing the tendency of the applicator to rotate during the 40 to 50 hours of uterine intracavitary endocurietherapy. Patients with previously untreated invasive carcinoma of the uterine cervix, F.I.G.O. stages IB-IVA, were treated with two Kumar intracavitary endocurietherapy (ECT) applications of 2,500 rad each to point ''A,'' and 4,000 rad external-beam radiotherapy (EXRT) to midplane, for a total dose of 9,000 rad. The major complication rate was 2.7 %, and the local control rate was 85 % (22/26 patients) for stage I and II, and 91 % (10/11 patients) for stage III and IVA. (author).

1988-01-01

185

Low morbidity following 9,000-rad intracavitary endocurietherapy (ECT) using the Kumar cervical applicator and external-beam radiotherapy (EXRT) in the management of carcinoma of the uterine cervix  

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The Kumar Cervical Applicator minimizes patient discomfort and improves patient mobility while reducing the tendency of the applicator to rotate during the 40 to 50 hours of uterine intracavitary endocurietherapy. Patients with previously untreated invasive carcinoma of the uterine cervix, F.I.G.O. stages IB-IVA, were treated with two Kumar intracavitary endocurietherapy (ECT) applications of 2,500 rad each to point ''A,'' and 4,000 rad external-beam radiotherapy (EXRT) to midplane, for a total dose of 9,000 rad. The major complication rate was 2.7 %, and the local control rate was 85 % (22/26 patients) for stage I and II, and 91 % (10/11 patients) for stage III and IVA.

Kumar, P.P.; Good, R.R.; Scott, J.C.; Jones, E.O.; Lynch, G.; McCaul, G.F.

1988-04-01

186

Studies on serum protein fractions of patients with uterine cervical cancer undergoing radiotherapy. Relationship between changes in serum protein fractions and prognosis  

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The correlation between changes in serum protein fractions and patient prognosis was evaluated. The subjects were 84 patients with uterine cervical cancer treated with combined external pelvic irradiation and intracavitary irradiation using a remote afterloading system (RALS). Twenty one normal women served as controls. Serum levels of 23 protein components were determined before and after radiotherapy. All patients were followed up for 4 to 8 years after radiotherapy. Pretreatment serum levels of prealbumin (Prealb), [alpha][sub 2]HS glycoprotein ([alpha][sub 2]HS), [alpha][sub 2]-plasmin inhibitor ([alpha][sub 2]PI), transferrin (Tf), plasminogen (Pmg), albumin (Alb), IgM, and hemopexin (Hx) were significantly lower in the group of cervical cancer patients than the control group; and serum levels of [alpha][sub 1]-antichymotrypsin ([alpha][sub 1]X), haptoglobin (Hp), C9, fibrinogen (Fib), ceruloplasmin (Cp), [alpha][sub 1]-acid glycoprotein ([alpha][sub 1]AG), [alpha][sub 1]-antitrypsin ([alpha][sub 1]AT), and C4 were elevated. At the completion of radiotherapy, HP, C4, and Fib levels were significantly lower than those before radiotherapy; Prealb, [alpha][sub 2]HS, and [alpha][sub 2]PI were elevated. In patients who survived 4 years and 8 years, pretreatment levels of Cp, [alpha][sub 1]AG, Hp, and C9 were significantly reduced and Tf was elevated, as compared with those who died within 4 years. In those who survived more than 4 years, posttreatment levels of [alpha][sub 1]AT, Hp, [alpha][sub 1]X, Cp, and C9 were significantly reduced, although the serum level of C4 was elevated. Survival positively correlated with pretreatment levels of Tf, Pmg, and [alpha][sub 1]AT, but negatively correlated with AT III, Cp, C1Inh, IgA, [alpha][sub 1]AG, and C9. For posttreatment levels, it positively correlated with Pmg, C4, Prealb, Alb, [alpha][sub 2]M, and Hp, but negatively correlated with Tf, [alpha][sub 2]PI, AT III, [alpha][sub 1]AT, C1Inh, C9, and IgA. (N.K.).

Onizuka, Keiichiro; Yamada, Hiroki; Uwada, Osamu; Umemura, Yoshiro; Kuroki, Masaomi; Tateyama, Hiromichi (Miyazaki Prefectural Hospital (Japan)); Migita, Shunsuke

1994-09-01

187

Comparison of tumor regression rate of uterine cervical squamous cell carcinoma during external beam and intracavitary radiotherapy  

International Nuclear Information System (INIS)

We compared the radioresponse of cervical carcinoma that was closely related to local disease control by the tumor regression rate (RR) during intracavitary radiotherapy (ICRT) and external beam radiotherapy (EBRT) on the presumption that ICRT has a stronger treatment impact than EBRT because of its specific dose distribution. A total of 37 patients were treated by EBRT at 45.0 Gy over 5 weeks, followed by high-dose-rate ICRT at 6.0 Gy per weekly insertion at point A three to five times and by boost EBRT. RR was defined as the slope (day-1) of the tumor-volume shrinkage curve fit to an exponential regression equation. Assuming that the tumors were ellipsoid, the tumor volume was estimated using magnetic resonance (MR) images obtained before treatment, after 45.0 Gy of EBRT, and after the third ICRT insertion. RRs were compared based on the radiotherapy method. RR ranged between -0.008 to 0.093 day-1 (median 0.021 day-1) during EBRT and -0.001 to 0.097 day-1 (median 0.018 day-1) during ICRT, showing no significant difference or correlation between treatments. Contrary to expectations, RR did not directly relate to the impact of physical treatment. RR could be related to biological factors, such as the amount of tumor clearance and changes in tumor consistency during treatment. (author)

2008-01-01

188

Critérios de positividade para cervicografia digital: melhorando a sensibilidade do diagnóstico do câncer cervical/ Digital cervicography criteria: improving sensitivity in uterine cervical cancer diagnosis  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O objetivo deste trabalho foi validar critérios de positividade para cervicografia digital. Estudo realizado com 300 mulheres submetidas a protocolo clínico composto por exame citológico, uma avaliação por meio de cervicografia digital sem ampliação de imagem (Avaliação 1), e outra avaliação também usando cervicografia digital mas com ampliação adicional de imagem e os critérios de positividade propostos neste estudo (Avaliação 2). A idade média das mulh (more) eres foi de 27,6 anos. Os critérios de positividade para cervicografia digital foram identificados em 111 casos (100%) dos testes positivos para lesões precursoras do câncer do colo uterino e em 8 casos (2,6%) considerados falso-positivos. As avaliações 1 e 2 classificaram os exames como positivos (163; 54,3%) e suspeitos (146; 48,6%), respectivamente. Os resultados revelam que a cervicografia digital foi mais sensível (99,1%) e a citologia mais específica (100%). O desempenho alcançado pela cervicografia digital, quando aplicado os critérios de positividade, alcançou sensibilidade 4,5 vezes superior ao desempenho da citologia oncológica, além do baixo custo, sugerindo ser uma técnica factível. Abstract in english This study aimed to validate the scoring criteria for digital cervicography. The study enrolled 300 women submitted to a clinical protocol using cytological examination alone, digital cervicography without image magnification (Evaluation 1), and digital cervicography plus additional image magnification and considering the positive criteria (Evaluation 2). Women's mean age was 27.6 years. Positive criteria for digital cervicography were identified in 111 positive cases wit (more) h pre-cancerous cervical lesions (100%) and in 8 cases classified as false positives (2.6%). Evaluations 1 and 2 classified the tests as positive (163; 54.3%) and suspected (146; 48.6%), respectively. According to the findings, digital cervicography was more sensitive (99.1%) and cytology more specific (100%). Digital cervicography sensitivity increased by 4.5 times when the positive criteria were applied as compared to cytology alone, besides involving low cost, thus suggesting that it is a viable technique.

Franco, Eugênio Santana; Hyppólito, Silvia Bomfim; Franco, Rosana Gomes de Freitas Menezes; Oriá, Mônica Oliveira Batista; Almeida, Paulo César de; Pagliuca, Lorita Marlena Freitag; Rocha, Nelson Fernando Pacheco da

2008-11-01

189

Uterine peaking – sonographic sign of vesico-uterine adhesion  

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Full Text Available Objective: In this paper we present our observation of a specific sign on transvaginal ultrasound that may help basic minimal invasive surgeons diagnose vesico-uterine adhesions preoperatively. Methods: The ultrasound images of the latest eleven patients who were preoperatively diagnosed with vesico-uterine adhesions using transvaginal ultrasound were compared with their intraoperative findings. Results: Ultrasonography showed a spectrum of changes from obliterated anterior cul-de-sac to dense fibrosis between the lower uterine segment and cervix with the bladder. Horn- or beak-shaped streaks of tissue with the same density of uterine myometrium is a sign of fundal attachment of vesico-uterine adhesions or of complete anterior cul-de-sac obliteration with adhesions going between the uterus and the anterior abdominal wall. Fine papillary peaking is seen in cases of dense lower uterine segment and cervical fibrosis without fundal involvement. These signs combined with limited mobility of the cervix and bladder base correlated with the presence of dense vesico-uterine adhesions. Conclusion: The described sonographic signs, two static and the other dynamic, may help basic minimal invasive gynecological surgeons who do not have advanced laparoscopic skills and do not feel comfortable dealing with an obliterated anterior cul-de-sac or dense vesico-uterine space fibrosis predict the presence of dense vesico-uterine adhesions allowing them to choose another route that they may be more comfortable with such as vaginal or abdominal hysterectomy or request assistance from a more experienced colleague.

Walid, Mohammad Sami; Heaton, Richard L.

2011-01-01

190

PET in uterine malignancies  

Directory of Open Access Journals (Sweden)

Full Text Available Positron Emission Tomography (PET) or integrated PET/Computed Tomography (PET/CT) with 18F-Fluoro-Deoxy-Glucose (18F-FDG) is a functional imaging modality, useful in the characterization of undetermined morphological findings, and in the staging/re-staging of a large number of malignancies. Although its use in uterine malignancies has been poorly investigated, in recent years the employment of this technique has constantly increased. In this review, we evaluate the role of PET (/CT) with 18FFDG in uterine malignancies (cervical and endometrial cancers as well as uterine sarcomas), underlying its advantages and discussing its limitations. Metabolic and anatomic information given by PET/CT with 18F-FDG could be useful in the evaluation of local and distant disease involvement at the staging, in the detection of disease recurrence, and in the evaluation of the response after chemotherapy and/or radio-therapy.

Valeria Pirro; Andrea Skanjeti; Ettore Pelosi

2010-01-01

191

Fluorescence In Situ Hybridization(FISH) or Other In Situ Hybridization(ISH) Testing of Uterine Cervical Cells to Predict Precancer and Cancer. (Final).  

Science.gov (United States)

Screening for cervical cancer has the potential to detect precancerous lesions and cancers in early stages, which can be effectively treated. Screening tests currently used in the United States on cervical cell samples include the Papanicolaou(Pap) test t...

A. Earley E. E. Avendano I. J. Dahabreh J. Lamont J. M. Cowan K. Uhlig S. Feldman

2013-01-01

192

Uterine Fibroids  

Medline Plus

Full Text Available ... focused ultrasounds that are guided by magnetic resonance images to target and destroy uterine fibroids. The procedure ... the bowel or bladder and those outside the image area cannot be treated with FUA. Summary Uterine ...

193

Citologia oncológica, captura de híbridos II e inspeção visual no rastreamento de lesões cervicais/ Pap smear, hybrid capture II, and visual inspection in screening for uterine cervical lesions  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Avaliar as alterações na citologia oncológica, na captura híbrida II e na inspeção visual com ácido acético (IVA) a 5% em 684 mulheres atendidas em uma unidade de saúde, e avaliar o desempenho e a concordância entre os exames. Procurar descrever as características sócio-demográficas e reprodutivas (SDR) destas mulheres e sua associação com a presença de doença. As mulheres foram submetidas à coleta de citologia, captura e IVA, e as com exame positivo for (more) am submetidas à colposcopia com biopsia, se necessário. Foi calculado o desempenho dos testes e a associação dos fatores SDR com o diagnóstico histológico foi avaliada por intermédio do cálculo do odds ratio. Embora 198 mulheres apresentassem pelo menos um teste alterado, apenas 21 apresentaram lesão histológica. A sensibilidade dos testes foi semelhante enquanto as especificidades da IVA e da citologia foram maiores que a da captura híbrida II. Apenas a ausência de citologia esteve associada à presença de doença. O desempenho da citologia foi maior que o da IVA, que foi maior que o da captura. A ausência de citologia foi associada com doença histológica. Abstract in english The objective of this study was to evaluate alterations in Pap smear, hybrid capture II (HCII), and visual inspection with acetic acid (VIA) in 684 women treated at a primary health care unit. The performance and agreement of the exams were evaluated. The study also described social, demographic, and reproductive factors and their association with uterine cervical lesions. Women had specimens taken for Pap smear, HCII, and VIA. When at least one of the tests was positive, (more) colposcopy was performed and targeted biopsies were taken from any suspicious lesions. Performance of tests was evaluated. Women's distribution in relation to social, demographic, and reproductive factors and histological diagnosis was evaluated using the odds ratio. Among 198 women with at least one positive screening test, only 21 showed histological disease. Sensitivities of the tests were similar. VIA and Pap smear presented higher specificity than HCII. Only absence of a previous Pap smear was associated with the presence of histological disease. Pap smear performed better than VIA and HC II. Absence of previous cytology was associated with histological disease.

Gontijo, Renata Clementino; Derchain, Sophie Françoise Mauricette; Montemor, Eliana Borin Lopes; Sarian, Luis Otávio Zanatta; Serra, Márcia Milena Pivatto; Zeferino, Luiz Carlos; Syrjanen, Kari Juhani

2005-02-01

194

Citologia oncológica, captura de híbridos II e inspeção visual no rastreamento de lesões cervicais Pap smear, hybrid capture II, and visual inspection in screening for uterine cervical lesions  

Directory of Open Access Journals (Sweden)

Full Text Available Avaliar as alterações na citologia oncológica, na captura híbrida II e na inspeção visual com ácido acético (IVA) a 5% em 684 mulheres atendidas em uma unidade de saúde, e avaliar o desempenho e a concordância entre os exames. Procurar descrever as características sócio-demográficas e reprodutivas (SDR) destas mulheres e sua associação com a presença de doença. As mulheres foram submetidas à coleta de citologia, captura e IVA, e as com exame positivo foram submetidas à colposcopia com biopsia, se necessário. Foi calculado o desempenho dos testes e a associação dos fatores SDR com o diagnóstico histológico foi avaliada por intermédio do cálculo do odds ratio. Embora 198 mulheres apresentassem pelo menos um teste alterado, apenas 21 apresentaram lesão histológica. A sensibilidade dos testes foi semelhante enquanto as especificidades da IVA e da citologia foram maiores que a da captura híbrida II. Apenas a ausência de citologia esteve associada à presença de doença. O desempenho da citologia foi maior que o da IVA, que foi maior que o da captura. A ausência de citologia foi associada com doença histológica.The objective of this study was to evaluate alterations in Pap smear, hybrid capture II (HCII), and visual inspection with acetic acid (VIA) in 684 women treated at a primary health care unit. The performance and agreement of the exams were evaluated. The study also described social, demographic, and reproductive factors and their association with uterine cervical lesions. Women had specimens taken for Pap smear, HCII, and VIA. When at least one of the tests was positive, colposcopy was performed and targeted biopsies were taken from any suspicious lesions. Performance of tests was evaluated. Women's distribution in relation to social, demographic, and reproductive factors and histological diagnosis was evaluated using the odds ratio. Among 198 women with at least one positive screening test, only 21 showed histological disease. Sensitivities of the tests were similar. VIA and Pap smear presented higher specificity than HCII. Only absence of a previous Pap smear was associated with the presence of histological disease. Pap smear performed better than VIA and HC II. Absence of previous cytology was associated with histological disease.

Renata Clementino Gontijo; Sophie Françoise Mauricette Derchain; Eliana Borin Lopes Montemor; Luis Otávio Zanatta Sarian; Márcia Milena Pivatto Serra; Luiz Carlos Zeferino; Kari Juhani Syrjanen

2005-01-01

195

Radioterapia: percepção de mulheres com câncer cérvico-uterino Radioterapia: percepción de mujeres con cáncer cérvico-uterino Radiotherapy: perception of women with uterine-cervical cancer  

Directory of Open Access Journals (Sweden)

Full Text Available Realizou-se um estudo qualitaitvo com objetivo de conhecer a percepção das mulheres com câncer cérvico-uterino sobre a radioterapia, descrevendo as alterações físicas e cotidianas sofridas e evidenciando meios de enfrentamento e expectativas em relação ao tratamento. Foram entrevistadas 20 mulheres em um hospital especializado, localizado na cidade de Teresina-PI. Os resultados mostraram que elas percebem a radioterapia como um bom tratamento, apesar do medo diante do desconhecido e das limitações no cotidiano, devido aos efeitos colaterais, que são enfrentados com suporte na religiosidade e no âmbito sócio-familiar, aumentando a expectativa de cura. Revelou-se a importância da orientação a essas mulheres pela equipe multiprofissional, especialmente o Enfermeiro, em todas as fases do tratamento.Se realizó un estudio con abordaje cualitativo objetivando conocer la percepción de las mujeres con cáncer cérvico-uterino sobre la radioterapia, describiendo las alteraciones físicas y cotidianas sufridas y evidenciando el medio utilizado para que enfrenten esas adversidades y sus expectativas con relación al tratamiento. Fueron entrevistadas 20 mujeres en un hospital especializado, localizado en la ciudad de Teresina-PI. Los resultados mostraron que ellas perciben la radioterapia como un buen tratamiento, a pesar del miedo delante de lo desconocido y de las limitaciones en el cotidiano, debido a los efectos colaterales, que son enfrentados con base en la religiosidad y en el ámbito socio-familiar, aumentando la expectativa de cura. Se reveló la importancia de la orientación a esas mujeres por el equipo multiprofesional, especialmente el Enfermero, en todas las fases del tratamiento.This is a qualitiative study that aimed to know the perception of women with uterine-cervical cancer on the radiotherapy, describing the physical and daily alterations they suffered and evidencing the their coping to face these adversities and their expectations about the treatment. 20 women in a specialized hospital had been interviewed, located in the city of Teresina-PI. The results showed that they perceive the radiotherapy as a good treatment, although the fear ahead of the stranger and the limitations in the daily one, had to the side-effects, that are faced with support in the religious and the social-familiar scope, increasing the cure expectation. The importance of the orientation to these women for the multiprofessional team showed, especially the Nurse, in all the phases of the treatment.

Lúcia Helena Rios Barbosa de Almeida; Yarla Brena Araújo de Sousa Pereira; Thais Alexandre de Oliveira

2008-01-01

196

Spontaneous uterine rupture at 32 weeks of gestation after previous uterine artery embolization.  

UK PubMed Central (United Kingdom)

Uterine artery embolization (UAE) is a common treatment for post-partum hemorrhage and uterine fibroids. However, the effects of UAE on subsequent pregnancies have not been established. Here, we present a case of spontaneous uterine rupture after previous UAE. A 31-year-old woman underwent UAE for a cervical ectopic pregnancy. Contrast-enhanced magnetic resonance imaging (MRI) at days 5 and 25 post-UAE suggested a regionally decreased blood supply in the mid-posterior wall of the uterine fundus. During a subsequent pregnancy at age 35 years, she underwent an emergency cesarean delivery due to spontaneous uterine rupture at the mid-posterior wall of the uterus at 32 weeks of gestation. Obstetricians should be attentive to the possibility of spontaneous uterine rupture in pregnant women who have previously undergone UAE. Detection of ischemic uterine muscle on MRI may predict potential for uterine rupture in a subsequent pregnancy.

Takeda J; Makino S; Ota A; Tawada T; Mitsuhashi N; Takeda S

2013-08-01

197

Treg cells in different forms of uterine cancer.  

UK PubMed Central (United Kingdom)

Recently, studies involving uterine cervical cancer and uterine corpus cancer have been reported from many institutes. The presence of regulatory T cells (Treg cells) in human uterine cancer is crucial for maintaining immunological homeostasis. To improve treatment strategies, I will be reviewing recent studies in the field. This work will discuss the central role that Treg cells play in the development of uterine cancer, which makes these cells a key missing component in current cancer immunotherapy.

Hou F; Ma D; Cui B

2013-01-01

198

Microinvasive carcinoma of the uterine cervix.  

UK PubMed Central (United Kingdom)

There has been remarkable improvement in the early diagnosis of cervical carcinoma in recent years. There is, however, disagreement regarding the definition and treatment of microinvasive carcinoma of the uterine cervix. This review analyzes a large number of reports representing current opinion about the definition, diagnosis and appropriate management of early cervical carcinoma.

Javaheri G

1979-01-01

199

A percepção da mulher sobre o exame preventivo do câncer cérvico-uterino: estudo de caso Women's perceptions of preventive examinations for cervical-uterine cancer: a case study  

Directory of Open Access Journals (Sweden)

Full Text Available O câncer cérvico-uterino é uma das doenças crônico-degenerativas mais temidas, em razão do seu alto grau de letalidade e morbidade. Nesse sentido, realizamos um estudo para descrever a percepção das mulheres ante o exame de prevenção de câncer cérvico-uterino. Optamos por um estudo de caso tendo a observação e a entrevista semi-estruturada como técnicas de coleta das informações. Foram entrevistadas vinte e quatro mulheres, entre 18 e 60 anos, que buscaram o serviço de prevenção em uma unidade básica de saúde de Fortaleza-CE, entre abril e agosto de 2004. O estudo revelou que a mulher geralmente só procura fazer o exame de prevenção quando surgem sintomas, por ter vivenciado este exame com apreensão e medo pela possibilidade de um diagnóstico positivo de um câncer cérvico-uterino; sente-se constrangida em expor seu corpo e tê-lo examinado, sobretudo, quando o profissional de saúde é do sexo masculino; não tem conhecimento do corpo e tampouco de sua sexualidade. Esse resultado aponta para a necessidade de o profissional de saúde desenvolver atividades educativas junto às mulheres, no sentido de melhorar a relação profissional de saúdeusuária e, conseqüentemente, diminuir a incidência deste tipo de câncer, pela maior freqüência aos exames de prevenção.Cervical-uterine cancer is among the most feared chronic degenerative diseases, due its high mortality and morbidity rates. This study describes women's feelings before a preventive examination for cervical-uterine cancer, through a case study based on observations and semi-structured interviews as data collection techniques. A total of 24 women were interviewed, between eighteen and sixty years old, who attended the cancer prevention unit at a basic healthcare clinic in Fortaleza, Ceará State between April and August 2004. This study shows that women generally request these preventive examinations only when symptoms appear. They view this procedure with apprehension and fear, due to the possibility of a positive diagnosis of cervical-uterine cancer; they feel embarrassed at exposing their bodies for examination, particularly by male physicians; and they are poorly informed about their own bodies and even their own sexuality. These findings highlight the need for healthcare practitioners to conduct educational activities for women, in order to enhance professional relationships between healthcare providers and users, helping lower the rate of this type of cancer through more frequent preventive examinations.

Lucélia Maria Duavy; Fátima Lucia Ramos Batista; Maria Salete Bessa Jorge; João Bosco Feitosa dos Santos

2007-01-01

200

Vascular endothelial growth factor induces growth of uterine cervix and immune cell recruitment in mice.  

UK PubMed Central (United Kingdom)

Knowledge of uterine cervical epithelial biology and factors that influence its events may be critical in understanding the process of cervical remodeling (CR). Here, we examine the impact of exogenous vascular endothelial growth factor (VEGF) on uterine cervical epithelial growth in mice (nonpregnant and pregnant) treated with VEGF agents (recombinant and inhibitor) using a variety of morphological and molecular techniques. Exogenous VEGF altered various uterine cervical epithelial cellular events, including marked induction of growth, edema, increase in inter-epithelial paracellular space, and recruitment of immune cells to the outer surface of epithelial cells (cervical lumen). We conclude that VEGF induces multiple alterations in the uterine cervical epithelial tissues that may play a role in local immune surveillance and uterine cervical growth during CR.

Donnelly SM; Nguyen BT; Rhyne S; Estes J; Jesmin S; Mowa CN

2013-04-01

 
 
 
 
201

Micronúcleos em células do colo uterino em mulheres HIV+ segundo sua condição de imunidade/ Micronuclei in uterine cervical cells of women HIV+ according to immunocompetence markers  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVO: investigar a micronucleação (MN) em células esfoliadas do colo uterino de mulheres HIV+ observando as condições de imunidade aferidas pelos níveis de linfócitos CD4+ e da carga viral para o HIV (CV). MÉTODOS: foram obtidas coletas citológicas da junção escamocolunar de 23 pacientes HIV+ de Ambulatório de DST/AIDS. O grupo controle foi composto por mulheres assintomáticas do Ambulatório de Prevenção de Câncer Ginecológico do mesmo serviço. O ma (more) terial foi submetido a processamento citológico para leitura em microscopia de luz, com objetiva de imersão em 2.000 células por paciente. Para avaliação da condição imunitária das pacientes HIV+ investigamos os níveis de linfócitos CD4+ e CV. A análise estatística dos resultados se fez com os testes do ?2 e Kolmogorov-Smirnov. RESULTADOS: vinte e três pacientes compuseram o grupo de mulheres HIV+ e 19 formaram o grupo controle. Em todas as pacientes HIV+ e em 84,2% do grupo controle detectamos MN. Dezessete pacientes HIV+ (73,9%) tiveram mais de 7 MN. No grupo controle tivemos apenas 1 caso (5,2%) com mais de 7 MN. Houve tendência na associação de maiores quantidades de MN em mulheres com baixos níveis de linfócitos CD4+ e maiores níveis de CV, sem caracterizar correlação estatística. CONCLUSÕES: pacientes HIV+ em fase de AIDS têm maior ocorrência de MN que o grupo controle e, também, a frequência com que são detectados MN parece estar associada a piores condições clínicas da imunossupressão. Abstract in english PURPOSE: to investigate the micronucleation (MN) of exfoliated cells from the uterine cervix of HIV+ women according to immunocompetence status. We investigated the clinical conditions of immunocompetence by analyzing the levels of CD4+ lymphocytes and viral count for HIV (VC). METHODS: biological material was collected from 23 HIV+ patients whose cervical oncologic cytology results were negative. They were patients from the STD/AIDS-FCMS-PUCSP who underwent a cytobrush c (more) ollection in the squamous columnar junction. Similar material was obtained from 19 healthy control women. The material, about 2000 cells per patient, was processed for cytology using light microscopy and an immersion objective. To analyze the immunological status of HIV+ patients we used CD4+ count and VC. Statistical analysis was performed using the ?2 and Kolmorogov-Smirnov tests. RESULTS: twenty-three pacients composed the group of HIV+ women and 19 composed the control group. We found micronuclei (MN) in all HIV+ patients and in 84.2% of the control group. In 17 73.9% of the HIV+ patients and in 5.2% of the control group we found more than 7 MN cells. MN tended to occur more among women with poorer immunological status in the HIV+ group. CONCLUSIONS: HIV+ patients in the AIDS phase have a higher prevalence of micronucleated cells, as opposed to a control group. Also, the frequency of MN was associated with worse conditions of immunosuppression.

Mendes, Camila Figueira; Gardinalli Filho, Gildo; Furoni, Renato Marinho; Miranda, Luís Vicente Vélez; Boschini Filho, Júlio; Sampaio Neto, Luiz Ferraz De

2011-10-01

202

Evaluación del seguimiento de mujeres con cáncer cervicouterino en dos policlínicos. Pinar del Río/ Follow-up assessment of women suffering from cervical uterine cancer in two polyclinics, Pinar del Rio  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Introducción: A pesar de contar con un programa de detección precoz del cáncer cervicouterino de larga duración aún no se logran los resultados esperados. Objetivo: Caracterizar a las pacientes con cáncer invasor del cuello uterino en dos áreas de salud de Pinar del Río en el quinquenio 2003-2007. Material y Método: Estudio observacional, transversal, de cohorte, retrospectivo de mujeres de cualquier edad con diagnóstico de cáncer cervicouterino invasor. La inf (more) ormación de las pacientes se tomó de los registros automatizados de las lesiones de cuello uterino de la consulta provincial de Patología de Cuello, del Provincial de Cáncer (Dirección Provincial de Salud), y del de Mortalidad General (Dirección Provincial de Salud) así como de las historias clínicas de la Unidad Oncológica Provincial. Entre las variables estudiadas estuvieron si procedían o no del programa, edad, estadio clínico, tratamiento recibido, incidencia anual y el promedio en la etapa, la mortalidad y la letalidad. Resultados: Se encontró que el 70,6% de casos no se detectó por programa. La tasa de incidencia promedio fue 29.5 por 100000 mujeres de 15 años y más. Todas las pacientes recibieron el tratamiento oncoespecífico según estadio clínico. Las mayores tasas de mortalidad se encontraron en las pacientes en estadio IIIB al diagnóstico. Conclusiones: Se detectan fallas en la Atención Primaria de Salud, por falta de detección. Las tasas de incidencia de esta enfermedad no se han logrado disminuir. Y se siguen diagnosticando casos en estadios avanzados de la enfermedad, lo que acorta la sobrevida de estas pacientes. Abstract in english Introduction: Despite of having a program, for a long time, to the early detection of cervical uterine cancer, the results expected are not as far achieved. Objective: to characterize the patients suffering from invasive cervical uterine cancer in two health areas in Pinar del Rio province throughout five years (2003-2007). Material and Methods: observational, cross-sectional, cohort, retrospective study including women at every age with invasive cervical-uterine cancer. (more) The information concerning the patients was collected from the automated records of cervical uterine at the provincial office for cervix pathology treatment (Provincial Public Health Direction), general death rate (Provincial Public Health Direction) and from the clinical histories of the Provincial Cancer Unit. Among the variables studied were: coming or not from the program, age, clinical stage, treatment followed, and annual incidence, together with the average of mortality and lethality considering the clinical stages. Results: 70,6% of the cases were not detected by the program. The average incidence rate was 29.5 per 10 0000 women from 15 years old or older. All patients underwent to a specific cancer treatment according to the clinical stage. The greatest mortality rates were found in patients presenting IIIB stage at diagnosis. Conclusion: errors were observed in Primary Health Care leading to deficiencies in the early detection of this type cancer. The incidence rates of this disease have not diminished; cases suffering from advanced stages of the disease are still detected, shortening the survival rate of these patients.

Sanabria Negrín, José Guillermo; Cruz Hernández, Inalvis de la Caridad; Oriolo Pérez, Leonardo; Pérez Herrera, Miguel Angel; Valdés Abreu, Beatriz

2012-06-01

203

Evaluación del seguimiento de mujeres con cáncer cervicouterino en dos policlínicos. Pinar del Río Follow-up assessment of women suffering from cervical uterine cancer in two polyclinics, Pinar del Rio  

Directory of Open Access Journals (Sweden)

Full Text Available Introducción: A pesar de contar con un programa de detección precoz del cáncer cervicouterino de larga duración aún no se logran los resultados esperados. Objetivo: Caracterizar a las pacientes con cáncer invasor del cuello uterino en dos áreas de salud de Pinar del Río en el quinquenio 2003-2007. Material y Método: Estudio observacional, transversal, de cohorte, retrospectivo de mujeres de cualquier edad con diagnóstico de cáncer cervicouterino invasor. La información de las pacientes se tomó de los registros automatizados de las lesiones de cuello uterino de la consulta provincial de Patología de Cuello, del Provincial de Cáncer (Dirección Provincial de Salud), y del de Mortalidad General (Dirección Provincial de Salud) así como de las historias clínicas de la Unidad Oncológica Provincial. Entre las variables estudiadas estuvieron si procedían o no del programa, edad, estadio clínico, tratamiento recibido, incidencia anual y el promedio en la etapa, la mortalidad y la letalidad. Resultados: Se encontró que el 70,6% de casos no se detectó por programa. La tasa de incidencia promedio fue 29.5 por 100000 mujeres de 15 años y más. Todas las pacientes recibieron el tratamiento oncoespecífico según estadio clínico. Las mayores tasas de mortalidad se encontraron en las pacientes en estadio IIIB al diagnóstico. Conclusiones: Se detectan fallas en la Atención Primaria de Salud, por falta de detección. Las tasas de incidencia de esta enfermedad no se han logrado disminuir. Y se siguen diagnosticando casos en estadios avanzados de la enfermedad, lo que acorta la sobrevida de estas pacientes.Introduction: Despite of having a program, for a long time, to the early detection of cervical uterine cancer, the results expected are not as far achieved. Objective: to characterize the patients suffering from invasive cervical uterine cancer in two health areas in Pinar del Rio province throughout five years (2003-2007). Material and Methods: observational, cross-sectional, cohort, retrospective study including women at every age with invasive cervical-uterine cancer. The information concerning the patients was collected from the automated records of cervical uterine at the provincial office for cervix pathology treatment (Provincial Public Health Direction), general death rate (Provincial Public Health Direction) and from the clinical histories of the Provincial Cancer Unit. Among the variables studied were: coming or not from the program, age, clinical stage, treatment followed, and annual incidence, together with the average of mortality and lethality considering the clinical stages. Results: 70,6% of the cases were not detected by the program. The average incidence rate was 29.5 per 10 0000 women from 15 years old or older. All patients underwent to a specific cancer treatment according to the clinical stage. The greatest mortality rates were found in patients presenting IIIB stage at diagnosis. Conclusion: errors were observed in Primary Health Care leading to deficiencies in the early detection of this type cancer. The incidence rates of this disease have not diminished; cases suffering from advanced stages of the disease are still detected, shortening the survival rate of these patients.

José Guillermo Sanabria Negrín; Inalvis de la Caridad Cruz Hernández; Leonardo Oriolo Pérez; Miguel Angel Pérez Herrera; Beatriz Valdés Abreu

2012-01-01

204

Dental 'erosion' revisited.  

UK PubMed Central (United Kingdom)

The term "erosion," as currently used in dentistry, is not only a misnomer but also is misleading, according to the authors. The authors highlight the critical roles of occlusal function and parafunction in the multifactorial etiology of cervical lesions and relate their significance to clinical practice. They propose a revised nomenclature for and classification of dental hard tissue lesions.

Grippo JO; Simring M

1995-05-01

205

Uterine Fibroids  

Medline Plus

Full Text Available ... Ablation uses focused ultrasounds that are guided by magnetic resonance images to target and destroy uterine fibroids. ... uses a device that combines two systems – a magnetic resonance imaging (MRI) machine to visualize patient anatomy, ...

206

Uterine Fibroids  

Medline Plus

Full Text Available ... monitor the temperature of the uterine tissue after heating, and a focused ultrasound beam that heats and ... sound waves. The treatment requires repeated targeting and heating of fibroid tissue while the patient lies inside ...

207

Uterine Fibroids  

Medline Plus

Full Text Available ... of the body. Uterine fibroids are made of nodules of smooth muscle cells and fibrous tissue that ... the uterus. Fibroids may grow as a single nodule or in clusters. They may range in size ...

208

Uterine Fibroids  

Medline Plus

Full Text Available Uterine Fibroids Introduction Fibroids are common, benign tumors of the uterus. They can cause significant pain, as well as abnormal bleeding. About 30% of all women may have fibroids. Most ...

209

Uterine Cancer  

Science.gov (United States)

... is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, the lining of the uterus. This type of cancer is sometimes called endometrial cancer. The symptoms of ...

210

Possible evidence that dehydroepiandrosterone sulfate (DHA-S) stimulates cervical ripening by a membrane-mediated process: Specific binding-sites in plasma membrane from human uterine cervix  

International Nuclear Information System (INIS)

[en] Fetal adrenal steroid, dehydroepiandrosterone sulfate (DHA-S) is well known to promote cervical ripening in late pregnancy. The presence of sites specifically binding the DHA-S in plasma membrane was studied in human cervical fibroblasts prepared from pregnant uterus. The fibroblasts were incubated with 3H DHA-S and then fractionated into plasma membranes, cytosol, nuclei, and other organella debris. The specific activity of 3H-count in the plasma membrane fraction was enriched ? 7-fold compared with the whole homogenate. When the isolated plasma membrane preparations from the fibroblasts were exposed to 3H DHA-S, the binding showed saturation kinetics; an apparent equilibrium dissociation constant (Kd) of 12 nM, and the binding capacity (Bmax) of 1.25 pmol/mg protein. The present results suggest that DHA is bound to and recognized by components in plasma membrane, and may exert its action on cervical ripening through the membrane-mediated processes

1991-01-01

211

Resection of uterine septum using gynaecoradiological techniques.  

Science.gov (United States)

This paper presents further refinements in our technique for the resection of uterine septum. Fourteen patients [infertility (n = 9) and recurrent miscarriages (n = 5)] underwent in-office resection of a uterine septum under fluoroscopic control. The main outcome measure was complete resection of uterine septum. Resections were carried out using either hysteroscopic scissors in combination with a specially designed uterine balloon catheter, or microlaparoscopy scissors in conjunction with a cervical cannula. In all patients the septum was successfully resected without any intra-operative complications. We conclude that ambulatory gynaecoradiological resection of uterine septa is a safe and simple procedure. It avoids utilization of expensive operating room time, general anaesthesia, and some complications associated with hysteroscopic resection, such as fluid retention and electrolyte imbalance. PMID:10325267

Karande, V C; Gleicher, N

1999-05-01

212

Resection of uterine septum using gynaecoradiological techniques.  

UK PubMed Central (United Kingdom)

This paper presents further refinements in our technique for the resection of uterine septum. Fourteen patients [infertility (n = 9) and recurrent miscarriages (n = 5)] underwent in-office resection of a uterine septum under fluoroscopic control. The main outcome measure was complete resection of uterine septum. Resections were carried out using either hysteroscopic scissors in combination with a specially designed uterine balloon catheter, or microlaparoscopy scissors in conjunction with a cervical cannula. In all patients the septum was successfully resected without any intra-operative complications. We conclude that ambulatory gynaecoradiological resection of uterine septa is a safe and simple procedure. It avoids utilization of expensive operating room time, general anaesthesia, and some complications associated with hysteroscopic resection, such as fluid retention and electrolyte imbalance.

Karande VC; Gleicher N

1999-05-01

213

Avaliação do Comprimento do Colo Uterino nas Posições Ortostática e Decúbito Horizontal nas Gestações Gemelares Uterine Cervical Length Evaluation in the Standing and Recumbent Positions in Twin Pregnancies  

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Full Text Available Objetivo: avaliação ultra-sonográfica e comparação da medida do comprimento do colo uterino nas gestações gemelares com as pacientes nas posições de decúbito dorsal horizontal (DDH) e ortostática. Métodos: 50 gestações gemelares foram submetidas a avaliações ultra-sonográficas para medida do comprimento do colo uterino no período de maio de 1999 a dezembro de 2000. Os exames foram realizados pela via transvaginal com periodicidade de 4 semanas totalizando 136 avaliações. A cérvice uterina foi avaliada, segundo técnica normatizada, com a paciente nas posições de decúbito dorsal horizontal e ortostática. Resultados: as medidas do colo uterino nas posições DDH e ortostática na primeira avaliação apresentaram correlação inversa com a idade gestacional (DDH: r=-0,60; pPurpose: to compare cervical length measurements in twin pregnancies obtained by transvaginal ultrasound examination in the recumbent and standing positions. Methods: fifty twin pregnancies underwent transvaginal ultrasound examinations to measure the cervical length with the women in recumbent and standing positions. The study was carried out between May 1999 and December 2000. The scans were repeated every 4 weeks and the total number of evaluations was 136. Two groups were analyzed: one included only the first ultrasound examinations carried out in each woman and the second group included all evaluations. Results: in the first group, cervical length measurements in the standing and recumbent positions correlated inversely with the gestational age (recumbent: r=-0.60; p<0.001; standing: r=-0.46; p=0.008). The mean measure in the recumbent position was 35.2 mm (SD=9.9 mm) and 33.4 mm (SD=9.5 mm) in the standing position. When the difference between the measure obtained in the standing and recumbent positions was expressed as percentage of the measure in the recumbent position, there was no significant association with gestational age (p=0.07). When all evaluations were considered, there was a significant association between cervical length in the recumbent and standing positions (r=0.79; p<0.001). The measures in recumbent and standing positions were inversely correlated with gestational age (recumbent: p<0.0001; standing: p<0.0001). The mean cervical length in the recumbent position was 33.5 mm (SD=10.8 mm) and 31.8 mm (SD=9.6 mm) in the standing position. There was no significant association between cervical length difference expressed as percentage of the measure in the recumbent position and gestation. Conclusion: cervical length measure obtained with the patients in the recumbent and standing positions provided similar information.

Tatiana Bernáth; Maria de Lourdes Brizot; Adolfo Wenjaw Liao; Luciana Cury; Jorge Demétrio Banduki; Marcelo Zugaib

2002-01-01

214

Primary Study on Providing a Basic System for Uterine Cervical Screening in a Developing Country: Analysis of Acceptability of Self-sampling in Lao PDR.  

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Background: Most developing countries have been unable to implement well-organized health care systems, especially comprehensive Pap smear screening-based programs. One of the reasons for this is regional differences in medical services, and a low-cost portable cervical screening system is necessary. To improve regional discrepancies in cervical screening systems, we investigated the usefulness and acceptability of cervical self- sampling by liquid-based cytology (LBC) for 290 volunteers in the Lao PDR. Materials and Methods: Following health education with comprehensive documents, cervical self-sampling kits by LBC were distributed in three provincial, district, and village areas to a total of 290 volunteers, who were asked to take cytology samples by themselves. Subsequently, the acceptability of self-sampling was evaluated using a questionnaire. Results: The documents were well understood in all three regions. Regarding the acceptability of self-sampling, the selections for subsequent screening were 62% self-sampling, 36% gynecologist-sampling, 1% either method, and 1% other methods. The acceptability rates were higher in the district and the village than in the province. For the relationship between acceptability and pregnancy, the self-sampling selection rate was higher in the pregnancy-experienced group (75%) than in the pregnancy-inexperienced group (60%). For the relationship between selection of self-sampling and experience of screening, the self-sampling selection rate was higher in the screening-inexperienced group (62%) than in the screening-experienced group (52%). Conclusions: Our data show that this new way forward, involving a combination of self-sampling and LBC, is highly acceptable regardless of age, educational background, and residence in rural areas in a developing country. PMID:23803074

Yoshida, Tomomi; Nishijima, Yoshimi; Hando, Kiyomi; Vilayvong, Soulideth; Arounlangsy, Petsamone; Fukuda, Toshio

2013-01-01

215

Primary Study on Providing a Basic System for Uterine Cervical Screening in a Developing Country: Analysis of Acceptability of Self-sampling in Lao PDR.  

UK PubMed Central (United Kingdom)

Background: Most developing countries have been unable to implement well-organized health care systems, especially comprehensive Pap smear screening-based programs. One of the reasons for this is regional differences in medical services, and a low-cost portable cervical screening system is necessary. To improve regional discrepancies in cervical screening systems, we investigated the usefulness and acceptability of cervical self- sampling by liquid-based cytology (LBC) for 290 volunteers in the Lao PDR. Materials and Methods: Following health education with comprehensive documents, cervical self-sampling kits by LBC were distributed in three provincial, district, and village areas to a total of 290 volunteers, who were asked to take cytology samples by themselves. Subsequently, the acceptability of self-sampling was evaluated using a questionnaire. Results: The documents were well understood in all three regions. Regarding the acceptability of self-sampling, the selections for subsequent screening were 62% self-sampling, 36% gynecologist-sampling, 1% either method, and 1% other methods. The acceptability rates were higher in the district and the village than in the province. For the relationship between acceptability and pregnancy, the self-sampling selection rate was higher in the pregnancy-experienced group (75%) than in the pregnancy-inexperienced group (60%). For the relationship between selection of self-sampling and experience of screening, the self-sampling selection rate was higher in the screening-inexperienced group (62%) than in the screening-experienced group (52%). Conclusions: Our data show that this new way forward, involving a combination of self-sampling and LBC, is highly acceptable regardless of age, educational background, and residence in rural areas in a developing country.

Yoshida T; Nishijima Y; Hando K; Vilayvong S; Arounlangsy P; Fukuda T

2013-01-01

216

A case report of anal cancer preceded by perianal Paget's disease after irradiation for uterine cervical cancer and review of perianal Paget's disease in Japan  

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The patient was a 59-year-old woman. Total hysterectomy and irradiation were performed for uterine cervical cancer 25 year previously. Paget's cells resembling signet ring cells were found in the epidermis, and anal cancer was present adjacent to them. The histological diagnosis of the anal cancer was mainly well differentiated adenocarcinoma, but mucinous carcinoma was present containing signet ring cells at sites contiguous with the anal glands, and lymphatic permeation was noted in the dermis. The cancer and the Paget's cells were both positive for PAS and alcian blue staining and were negative for PB/KOH/PAS staining. Furthermore, such findings as atypia of the glandular ducts and endoarteritis were detected in the underlying mucosa. Therefore, it was considered that this patient had anal cancer derived from the anal glands, that the Paget's cells were due to the intraepidermal extension of signet ring cells, and that the cancer may have been related to her previous irradiation. Reports of cancer of the rectum and anus complicated by Paget's lesion in Japan were reviewed and studied with regard to the histogenesis. It was concluded that peri-anal Paget's lesion had a close relationship with anal cancer derived from the anal glands. (author).

Kumegawa, Hiroshi; Shirouzu, Kazuo; Isomoto, Hiroharu; Araki, Yasuzo; Morodomi, Tachisumi; Nakagawa, Kiichiro; Kakegawa, Teruo (Kurume Univ., Fukuoka (Japan). School of Medicine)

1991-03-01

217

Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells.  

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Recently we have demonstrated that anthocyanins from fruits of Vitis coignetiae Pulliat (AIMs) have anticancer effects. Here, we investigate the effects of AIMs on cell proliferation and invasion as well as epithelial-mesenchymal transition (EMT) which have been linked to cancer metastasis in human uterine cervical cancer HeLa cells. AIMs inhibited the invasion of HeLa cells in a dose-dependent manner. AIMs inhibited MMP-9 expression in a dose-dependent manner. AIMs inhibited the motility of HeLa cells in a wound healing test. AIMs still suppressed NF- ? B activation induced by TNF. AIMs also inhibited EMT in HeLa cells. AIMs suppressed vimentin, N-cadherin, and ?-catenin expression and induced E-cadherin. AIMs also suppressed expression of ?-catenin and Snail, which was regulated by GSK-3. These effects of AIMs were also limited in the HeLa cells treated with TNF. In conclusion, this study indicates that AIMs have anticancer effects by suppressing NF- ? B-regulated genes and EMT, which relates to suppression of I ? B ? phosphorylation and GSK-3 activity, respectively. However, the effects of AIMs were attenuated in the TNF-high condition.

Lu JN; Lee WS; Yun JW; Kim MJ; Kim HJ; Kim DC; Jeong JH; Choi YH; Kim GS; Ryu CH; Shin SC

2013-01-01

218

Uterine avulsion: a rare cause of cryptomenorrhea.  

UK PubMed Central (United Kingdom)

BACKGROUND: Cryptomenorrhea at menarche is commonly due to mullerian duct anomalies. Uterine avulsion due to blunt pelvic trauma is a very rare cause of cryptomenorrhea. But so far no case of uterine avulsion has been reported due to a childhood trauma without pelvic fracture. CASE: A 15-year-old young girl was evaluated for delayed menarche and the diagnosis of hematometra with obstruction at the level of internal cervical os was made on radiological examination. Detailed history revealed significant childhood blunt pelvic trauma when at the age of 3 years she was run over by a tractor. But the presence or absence of pelvic fracture was never documented as no radiographs were obtained. On abdominopelvic exploration cervix was well formed. Uterine body was found to be separated from the supravaginal cervix and there was a peritoneal window in between. During surgery hematometra was drained and the continuity of the uterine outflow tract was restored. Post surgery patient started having normal periods. SUMMARY AND CONCLUSIONS: Though very rare, uterine avulsion during pelvic trauma may cause cryptomenorrhea. Therefore such history should be sought in all cases of obstruction of the cervical canal because cryptomenorrhea has a much better prognosis than cervical congenital dysgenesis.

Rashmi; Suneja A; Yadav P; Sharma A; Vaid NB

2009-06-01

219

Lesões precursoras do câncer cervicouterino: evolução histórica e subsídios para consulta de enfermagem ginecológica/ Cervical-uterine cancer precursor lesions: historical evolution supporting the gynecological nursing consultation/ Lesiones precursoras del cáncer cervical-útero: evolución histórica consolidando la consulta de enfermería ginecológica  

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Full Text Available Abstract in portuguese Estudo emergido de recorte de dissertação de mestrado, ilustrando a evolução histórica das lesões precursoras do câncer cervicouterino (LPCCU). Trata-se da história das LPCCU, delineando a relevância do conhecimento para prática do enfermeiro na área da saúde da mulher. O conceito de LPCCU inicia-se a partir do século XIX, dando início aos estudos das células alteradas. Objetivo: descrever as diversas fases da evolução histórica das alterações cervicai (more) s. Estudo qualitativo, descritivo-analítico, recorte temporal no período de 1940 a 2008. Dados levantados mediante bibliografia de fonte primária e recurso BIREME. Pontuaram-se as classificações que já existiram, destacando a Nomenclatura Brasileira, importante para corresponder às necessidades e o perfil da saúde das mulheres do Brasil. Este estudo é o ponto de partida para respaldar as práticas de consulta de enfermagem ginecológica com abordagens educativas, contemplando a população feminina em ações preventivas e incentivo ao tratamento. Abstract in spanish Estudio emergido de recorte de disertación de máster, ilustrando la evolución histórica de las lesiones precursoras del cáncer cervical-uterino (LPCCU). Se trata de la historia de las LPCCU, delineando la relevancia del conocimiento para la práctica del enfermero en cuidados en la salud de la mujer. El concepto de LPCCU se inicia a partir del siglo XIX, empezando los estudios de las células alteradas. Como objetivo: describir las diversas fases históricas de las a (more) lteraciones cervicales. Estudio cualitativo, descriptivo-analítico, recorte temporal en el período de 1940 hasta 2008. Datos acrecentados mediante bibliografía de fuente primaria y recurso BIREME. Se puntuó las diferentes clasificaciones que ya existieron, conde destaque para la nomenclatura brasileña, importante para corresponder a las necesidades y el perfil de la salud de las mujeres del Brasil. Esto estudio es el ponto de partida para respaldar las prácticas de consulta de enfermería ginecológica con abordajes educativas, contemplando la población femenina en acciones preventivas y incentivo al tratamiento. Abstract in english Study emerged from an article of the master degree that illustrates the phases of the historical evolution of the precursor lesions of the cervical-uterine cancer. Thus, it is a question of the history about, delineating the relevance of this knowledge for the nurse's practice in care in the woman's health. The precursor lesions concept of the cervical-uterine cancer, initiates itself from the XIX century, beginning with studies of the cells altered. It had as objective: (more) describe the diverse historical phases of the cervical-uterine cancer. A qualitative, descriptive-analytical study, using time cutting in the period of 1940 to 2008. The data were raised by means of bibliographical reference as primary spring and about the resource BIREME, By means of this study was possible to score the different classifications that already existed, highlighting the Brazilian Nomenclature was important to correspond the needs and the profile of the health of the women of Brazil. This study is the starting point to support the gynecological nursing consultation practices with educational approaches, contemplating the female population in preventive actions and incentive to the treatment.

Carvalho, Maria Cristina de Melo Pessanha; Queiroz, Ana Beatriz Azevedo

2010-09-01

220

Uterine hemangiopericytoma.  

UK PubMed Central (United Kingdom)

In a clinicopathologic analysis of previously unreported uterine hemangiopericytomas, malignant behavior was observed in four of 21 followed patients. Recurrent disease occurred in the pelvis, abdomen, and lungs. The role of chemotherapy in the treatment of recurrences was not substantiated. No specific histologic features could be identified that correlated with malignant potential.

Buscema J; Klein V; Rotmensch J; Rosenshein N; Woodruff JD

1987-01-01

 
 
 
 
221

Explanation for the failure of neoadjuvant chemotherapy to improve outcomes after radiotherapy for locally advanced uterine cervical cancer from the standpoint of the tumor regression rate  

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Treatment outcomes for patients with locally advanced cervical cancer are no better with neoadjuvant chemotherapy (NAC) combined with radiotherapy (RT) than with RT alone. We investigated the reason for this failure from the standpoint of the tumor regression rate (RR). A total of 48 patients with clinical stage IIB-IVA cervical squamous cell carcinoma were treated clinically with cisplatin-based NAC plus RT (n=15) or RT alone (n=33). The RR was defined as the slope of a tumor shrinkage curve derived with magnetic resonance images. The local control rate (LCR) and disease-free rate (DFR) were estimated by clinical stage (IIB vs. III-IVA), pretreatment volume (?median vs. >median), lymph node status (negative vs. positive), treatment type, overall treatment time (?8 weeks vs. >8 weeks), and RR (?median vs. >median) using univariate and multivariate analyses. RR during NAC or during NAC and RT (n=15) was not significantly higher than RR by RT alone (n=33). Low RR and positive nodal status were significantly powerful prognostic factors for both the LCR and DFR, whereas the others were not. Although effective in reducing tumor volume prior to RT, NAC showed no overall effect in increasing the RR, which was shown to be the most powerful prognostic factor. (author)

2007-01-01

222

[Histochemical analysis of uterine cervical adenocarcinoma with reference to mucosubstances and distribution of CEA, CA125 and CA19-9].  

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Epithelial mucin and immunohistochemical localization of carbohydrate antigens (CA125, CA19-9) in normal endocervical glands and adenocarcinoma of uterine cervix were examined histochemically. The materials were obtained from 33 surgical cases with adenocarcinoma and 9 control cases. Serial sections were examined by the following procedures: 1) Digestive PAS reaction, 2) High iron diamine-Alcian blue pH 2.5 staining, 3) Modification PAS and Thionin Schiff reaction to differentiate sialic acid, 4) Immuno-peroxidase method. Histologically, these adenocarcinomas were classified into four subtypes, endocervical, intestinal, endometrioid and serous adenocarcinoma. Endocervical adenocarcinomas were differentiated into the endocervical-intestinal group and serous-endometrioid group by mucin profiles and distribution of carbohydrate antigens. In endocervical and intestinal types, sialomucin was predominant, this mucin being characterized by O-acetylated sialic acid. Immunohistochemically, CA19-9, CA125 and CEA were localized in this group. The latter group of tumors were serous and endometrioid adenocarcinomas, characterized by surface coat type sulphomucin and non-acetylated sialic acid, but CA19-9 and CA125 were not detected in these cases. Adenoma malignum was classified in endocervical type adenocarcinoma. PMID:3163714

Maruyama, C; Yamamichi, N; Konishi, F

1988-04-01

223

[Histochemical analysis of uterine cervical adenocarcinoma with reference to mucosubstances and distribution of CEA, CA125 and CA19-9].  

UK PubMed Central (United Kingdom)

Epithelial mucin and immunohistochemical localization of carbohydrate antigens (CA125, CA19-9) in normal endocervical glands and adenocarcinoma of uterine cervix were examined histochemically. The materials were obtained from 33 surgical cases with adenocarcinoma and 9 control cases. Serial sections were examined by the following procedures: 1) Digestive PAS reaction, 2) High iron diamine-Alcian blue pH 2.5 staining, 3) Modification PAS and Thionin Schiff reaction to differentiate sialic acid, 4) Immuno-peroxidase method. Histologically, these adenocarcinomas were classified into four subtypes, endocervical, intestinal, endometrioid and serous adenocarcinoma. Endocervical adenocarcinomas were differentiated into the endocervical-intestinal group and serous-endometrioid group by mucin profiles and distribution of carbohydrate antigens. In endocervical and intestinal types, sialomucin was predominant, this mucin being characterized by O-acetylated sialic acid. Immunohistochemically, CA19-9, CA125 and CEA were localized in this group. The latter group of tumors were serous and endometrioid adenocarcinomas, characterized by surface coat type sulphomucin and non-acetylated sialic acid, but CA19-9 and CA125 were not detected in these cases. Adenoma malignum was classified in endocervical type adenocarcinoma.

Maruyama C; Yamamichi N; Konishi F

1988-04-01

224

Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2)  

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Purpose: To determine the efficacy of a definitive radiotherapy protocol using high-dose-rate intracavitary brachytherapy (HDR-ICBT) with a low cumulative dose schedule in nonbulky early-stage cervical cancer patients, we conducted a prospective multi-institutional study. Methods and Materials: Eligible patients had squamous cell carcinoma of the intact uterine cervix, Federation of Gynecologic Oncology and Obstetrics (FIGO) stages Ib1, IIa, and IIb, tumor size <40 mm in diameter (assessed by T2-weighted magnetic resonance imaging), and no pelvic/para-aortic lymphadenopathy. The treatment protocol consisted of whole-pelvis external beam radiotherapy (EBRT) of 20 Gy/10 fractions, pelvic EBRT with midline block of 30 Gy/15 fractions, and HDR-ICBT of 24 Gy/4 fractions (at point A). The cumulative biologically effective dose (BED) was 62 Gy{sub 10} ({alpha}/{beta} = 10) at point A. The primary endpoint was the 2-year pelvic disease progression-free (PDPF) rate. All patients received a radiotherapy quality assurance review. Results: Between September 2004 and July 2007, 60 eligible patients were enrolled. Thirty-six patients were assessed with FIGO stage Ib1; 12 patients with stage IIa; and 12 patients with stage IIb. Median tumor diameter was 28 mm (range, 6-39 mm). Median overall treatment time was 43 days. Median follow-up was 49 months (range, 7-72 months). Seven patients developed recurrences: 3 patients had pelvic recurrences (2 central, 1 nodal), and 4 patients had distant metastases. The 2-year PDPF was 96% (95% confidence interval [CI], 92%-100%). The 2-year disease-free and overall survival rates were 90% (95% CI, 82%-98%) and 95% (95% CI, 89%-100%), respectively. The 2-year late complication rates (according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer of Grade {>=}1) were 18% (95% CI, 8%-28%) for large intestine/rectum, 4% (95% CI, 0%-8%) for small intestine, and 0% for bladder. No Grade {>=}3 cases were observed for genitourinary/gastrointestinal late complications. Conclusions: These results suggest that definitive radiotherapy using HDR-ICBT with a low cumulative dose schedule (BED, 62 Gy{sub 10} at point A) can provide excellent local control without severe toxicity in nonbulky (<4-cm) early-stage cervical cancer.

Toita, Takafumi, E-mail: b983255@med.u-ryukyu.ac.jp [Department of Radiology, Graduate School of Medical Science, University of Ryukyus, Okinawa (Japan); Kato, Shingo [Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Niibe, Yuzuru [Department of Radiology, School of Medicine, Kitasato University, Sagamihara (Japan); Ohno, Tatsuya [Gunma University Heavy Ion Medical Center, Maebashi (Japan); Kazumoto, Tomoko [Department of Radiology, Saitama Cancer Center, Saitama (Japan); Kodaira, Takeshi [Department of Radiation Oncology, Aichi Cancer Center, Nagoya (Japan); Kataoka, Masaaki [Department of Radiology, National Shikoku Cancer Center, Ehime (Japan); Shikama, Naoto [Department of Radiation Oncology, Saku Central Hospital, Saku (Japan); Kenjo, Masahiro [Department of Radiation Oncology, Graduate School of Medical Science, Hiroshima University, Hiroshima (Japan); Tokumaru, Sunao [Department of Radiology, Saga University, Saga (Japan); Yamauchi, Chikako [Department of Radiation Oncology, Shiga Medical Center for Adults, Moriyama (Japan); Suzuki, Osamu [Department of Radiation Oncology, Osaka Medical Center for Cancer, Osaka (Japan); Sakurai, Hideyuki [Proton Medical Research Center and Tsukuba University, Tsukuba (Japan); Numasaki, Hodaka; Teshima, Teruki [Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Suita, Osaka (Japan); Oguchi, Masahiko [Department of Radiation Oncology, Cancer Institute Hospital, Tokyo (Japan); Kagami, Yoshikazu [Radiation Oncology Division, National Cancer Center Hospital, Tokyo (Japan); Nakano, Takashi [Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi (Japan); Hiraoka, Masahiro [Department of Radiation Oncology and Image-applied Therapy, Kyoto University, Graduate School of Medicine, Kyoto (Japan); Mitsuhashi, Norio [Department of Radiation Oncology, Tokyo Women' s Medical University, Tokyo (Japan)

2012-01-01

225

Percepção da vulnerabilidade entre mulheres com diagnóstico avançado do câncer do colo do útero/ Perceiving vulnerability among women with advanced diagnosis of uterine cervical cancer/ La percepción de la vulnerabilidad entre mujeres con diagnóstico de cáncer cervical avanzado  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Estudo descritivo, de abordagem qualitativa, que objetivou compreender a percepção da vulnerabilidade à doença, entre mulheres com diagnóstico avançado do câncer do colo do útero, tendo como referencial, a vulnerabilidade. Participaram doze mulheres que estavam em atendimento ambulatorial hospitalar, para tratamento do câncer cérvico-uterino avançado. Os dados foram coletados por entrevistas e analisados por Análise de Conteúdo. Dos resultados emergiram duas (more) categorias temáticas: Percebendo-se vulnerável na descoberta da doença e Percebendo-se vulnerável na realização do tratamento. Fatores relacionados à cliente, profissionais, serviços, entre outros, tornaram a mulher suscetível aos problemas e danos de saúde, relativos ao câncer cérvico-uterino, exacerbando sua vulnerabilidade à doença. É necessário superar deficiências no modelo de assistência e humanização do atendimento, no grau de compromisso e qualidade das instituições, dos recursos, gerenciamento e monitoramento dos programas de prevenção e detecção do câncer do colo do útero, nos diferentes níveis de atenção. Abstract in spanish Este estudio descriptivo y cualitativo tuvo como objetivo comprender la percepción de la vulnerabilidad a la enfermedad, entre las mujeres diagnosticadas con cáncer cervical avanzado, tomando como referencia la vulnerabilidad. Participaron doce mujeres que recibían atención ambulatoria hospitalaria para el tratamiento del cáncer cervico uterino avanzado. La recolección de los datos se hizo a través de entrevistas y se analizaron mediante el análisis de contenido. (more) Los resultados destacan dos temas: Percepción de su vulnerabilidad al descubrir la enfermedad, y percepción de su vulnerabilidad al realizar el tratamiento. Factores relacionados con el cliente, los servicios, los profesionales, entre otros, han hecho que las mujeres sean susceptibles a los problemas de salud y daños relacionados con el cáncer cervico uterino, lo que agrava su vulnerabilidad a las enfermedades. Es necesario superar las deficiencias en el modelo de tratamiento para el cuidado y la integridad personal, el grado de compromiso y calidad de las instituciones, recursos, programas de gestión y control para prevenir y detectar el cáncer del cuello uterino, en los diferentes niveles de atención. Abstract in english This descriptive qualitative study aimed to comprehend perceptions of vulnerability to disease among women diagnosed with advanced cervical cancer. Twelve women who were receiving outpatient hospital care in treating advanced cervical cancer participated in the study. Data was collected through interviews and analyzed via content analysis. The results highlight two themes: Perceiving oneself as vulnerable in discovering the disease; and Perceiving oneself vulnerable in ca (more) rrying out treatment. Factors related to the client, health care professionals, and services rendered, among others have made women susceptible to health problems and damage relating to cervical cancer, exacerbating their vulnerability to the disease. It is necessary to overcome deficiencies in care model and the humanization of treatment, the degree of commitment, as well as the quality of institutions, resources, management and monitoring programs towards preventing and detecting cervical cancer within different levels of care.

Pimentel, Angela Vieira; Panobianco, Marislei Sanches; Almeida, Ana Maria de; Oliveira, Iácara Santos Barbosa

2011-06-01

226

MRI of uterine body cancer  

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We assessed the clinical utility of magnetic resonance imaging for the evaluation of myometrial and cervical invasion of uterine body cancer and compared the effects of administering Gd-DTPA as a magnetic enhancement agent with the finding on T2-weighted imaging. The detection rate of tumors was 90% with T2 imaging and 90.5% with enhancement imaging. Both were considered good. An important finding was that the absence of a junctional zone and irregularity of the tumor margin indicated the existence of myometrial invasion. However, a junctional zone was detected in 43.3% of T2 images and 23.3% of enhancement images. T2 imaging was superior to enhancement imaging for the determination of a junctional zone. There was no difference between T2 imaging and enhancement imaging with respected to the detection of tumor marginal irregularity. We applied the following five parameters for objective evaluation of myometrial invasion: axial area ratio, sagittal area ratio, volume ratio, minimal thickness, and minimum/maximum thickness ratio. We compared the correlations of both imaging techniques with the degree of myometrial invasion. All parameters of both types of imaging were useful for the evaluation of the degree of myometrial invasion. Our analysis showed that enhancement imaging was superior to T2 imaging for determination of the existence of deep myometrial invasion. It is possible that cervical invasion obscured when the cervical signal appeared as a linear pattern on sagittal imaging. However, it is difficult to diagnose cervical microinvasion and cervical involvement by imaging techniques. Furthermore, there were no remarkable findings in such cases even after administration of the contrast enhancement agent. We believe this is a limitation of imaging diagnosis. Thus, our results suggest that MRI is useful and appropriate for clinical staging of uterine body cancers. (author).

1993-01-01

227

Correlation of apoptosis with tumour cell differentiation, progression, and HPV infection in cervical carcinoma.  

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AIMS: To clarify the significance of apoptosis in the progression of uterine cervical neoplasias, including cervical intraepithelial neoplasia (CIN), microinvasive carcinoma (MIC), and invasive squamous cell carcinoma (ISCC) categories, in relation to cell proliferation and human papilloma virus (HP...

Shoji, Y; Saegusa, M; Takano, Y; Ohbu, M; Okayasu, I

228

A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy  

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Full Text Available Abstract Purpose We assessed the value of dose-volumetric parameters predicting rectosigmoid mucosal changes (RMC) and late rectosigmoid complications (LRC). Methods Between January 2004 and February 2006, 77 patients with stage IB-IIIB cervical cancer underwent external beam radiotherapy and computed tomography (CT)-based intracavitary irradiation. Total dose to the rectal point and several dose-volumetric parameters for rectosigmoid colon (D20cc, D15cc, D10cc, D5cc, D2cc, D1cc, and D0.1cc , defined as the minimal doses received by the highest irradiated volumes of 20, 15, 10, 5, 2, 1, and 0.1 cc, respectively), were calculated using the equivalent dose in 2 Gy fractions (?/??=?3, Gy3). The RMC and LRC were graded by rectosigmoidoscopy and Radiation Therapy Oncology Group criteria every 6 months, respectively. Results Of 77 patients, 27 (35.1%) patients developed RMC???score 3 and 22 (28.6 %) patients developed LRC???grade 2. There was a positive correlation between RMC score and LRC grade (r?=?0.728, p?5cc, among the dose-volumetric parameters, was significant parameter for the risks of RMC???score 3 and LRC???grade 2 (p??0.05). Conclusions D5cc may be a more reliable estimate than other dose-volumetric parameters for predicting the risk of RMC???score 3 and LRC???grade 2 in CT-based brachytherapy.

Kim Tae Hyun; Kim Joo-Young; Sohn Dae Kyung; Kim Yeon-Joo; Lee Yoon-Seok; Moon Sung Ho; Kim Sang Soo; Kim Dae Yong

2013-01-01

229

A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy.  

UK PubMed Central (United Kingdom)

PURPOSE: We assessed the value of dose-volumetric parameters predicting rectosigmoid mucosal changes (RMC) and late rectosigmoid complications (LRC). METHODS: Between January 2004 and February 2006, 77 patients with stage IB-IIIB cervical cancer underwent external beam radiotherapy and computed tomography (CT)-based intracavitary irradiation. Total dose to the rectal point and several dose-volumetric parameters for rectosigmoid colon (D20cc, D15cc, D10cc, D5cc, D2cc, D1cc, and D0.1cc , defined as the minimal doses received by the highest irradiated volumes of 20, 15, 10, 5, 2, 1, and 0.1 cc, respectively), were calculated using the equivalent dose in 2 Gy fractions (?/??=?3, Gy3). The RMC and LRC were graded by rectosigmoidoscopy and Radiation Therapy Oncology Group criteria every 6 months, respectively. RESULTS: Of 77 patients, 27 (35.1%) patients developed RMC???score 3 and 22 (28.6 %) patients developed LRC???grade 2. There was a positive correlation between RMC score and LRC grade (r?=?0.728, p?

Kim TH; Kim JY; Sohn DK; Kim YJ; Lee YS; Moon SH; Kim SS; Kim DY

2013-01-01

230

Combined radiation and chemotherapy for locally advanced cervical cancer: preliminary study; Radio-chimiotherapie concomitante dans les cancers du col uterin localement avances: etude preliminaire  

Energy Technology Data Exchange (ETDEWEB)

We have designed a combined treatment strategy of bifractionated split course radiotherapy (RT) and concomitant chemotherapy (CT) to try to improve the results of RT in inoperable cervical carcinoma. After evaluation, patients were submitted to further radical surgery or additional RT-CT depending on the treatment results. Between January 1992, 25 patients with non metastatic inoperable disease entered in the protocol. The stage of the disease was: T{sub 3}N{sub 0}4 patients, T{sub 3} with hydronephrosis seven patients, T{sub 3}N{sub 1} 12 patients, and T{sub 4}N{sub 0} two patients. Nineteen patients received two courses of CT with fluorouracil (F), cisplatin (P) with or without etoposide. Pelvic RT was given twice daily (two fractions of 3 Gy) on days 1, 3, 15 and 17. A combination of F 400 mg/m{sup 2}/d and P 15 mg/m{sup 2}/d in continuous infusion with oral etoposide (100 mg/d) and hydroxyurea (500 mg/d) in 11 patients was delivered concomitantly on days 1-3 and 14-17. A clinical and radiological evaluation was performed four weeks later. Patients with objective response underwent radical hysterectomy (group A) and those with incomplete response received additional RT-CT protocol (group B). All patients had endocavitary brachytherapy at the end of treatment. After two cycles of CT there were four PR in 19 patients and 5 failures. (authors). 36 refs., 1 fig.

Delanian, S.; Housset, M.; Maulard-Durdux, C. [Hopital Saint-Louis, 75 - Paris (France); Taurelle, R.; Lecuru, F. [Hopital boucicaut, 75 - Paris (France); Baillet, F. [Hopital Pitie-Salpetriere, 75 - Paris (France)

1995-12-31

231

Antimicrobial factors in the cervical mucus plug  

DEFF Research Database (Denmark)

The cervical mucus plug is positioned between the microbe-rich vagina and the normally sterile uterine cavity, which suggests a host defense function, but few relevant data are available. We analyzed the composition and antimicrobial activity of cervical mucus plugs.

Hein, Merete; Valore, Erika V

2002-01-01

232

Alterações citopatológicas e fatores de risco para a ocorrência do câncer de colo uterino/ Alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero/ Citopathological alterations and risk factors for uterine cervical neoplasm  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O objetivo do estudo foi verificar alterações citopatológicas e fatores de risco para o câncer de colo uterino em mulheres usuárias do Sistema Único de Saúde de um município de pequeno porte do norte do Paraná, de 2001 a 2006. Trata-se de um estudo observacional transversal descritivo. A coleta de dados foi realizada com os resultados dos exames, prontuários e entrevistas. Foram realizados 6.356 exames e 65(1,02%) apresentaram alterações. Dos exames realizados (more) , 4.869 (70,8%) foram em mulheres de 25 a 59 anos. 38,5% dos exames apresentaram Neoplasia Intraepitelial Cervical (NIC) I, 32,3% NIC II e 18,5% NIC I e Papiloma Vírus Humano (HPV). Foram entrevistadas 25 mulheres, a maioria apresentou algum fator de risco como: tabagismo, doenças sexualmente transmissíveis, uso de anticoncepcional hormonal, número de parceiros, início precoce da atividade sexual. Conclui-se pela necessidade de ações educativas mais efetivas no sentido de reduzir as alterações principalmente entre as mulheres adolescentes. Abstract in spanish El objetivo del estudio fue verificar alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero en mujeres atendidas por el Sistema Único de la Salud de una ciudad de pequeño porte en la Región Norte de la Provincia del Paraná, Brasil en el período de 2001 al 2006. Se trata de un estudio observacional transversal descriptivo. La colección de los datos fue realizada con los resultados de los exámenes, prontuarios y entrevi (more) stas. Fueron realizados 6.356 exámenes y 65(1,02%) presentaron alteraciones. De los exámenes hechos 4.869 (70,8%) fue compuesto de mujeres con edad entre los 25 a los 59 años. Un total de 38,5% de los exámenes presentaron Neoplasia Intra-epitelial del Cuello Uterino (NIC) I, 32,3% NIC II y 18,5% NIC I y Virus de Papiloma Humano (HPV). Fueron entrevistadas 25 mujeres, la mayoría presentó factores de riesgo como: tabaquismo, enfermedades de transmisión sexual, uso de anticonceptivo hormonal, número de parejas sexuales, inicio precoz de la actividad sexual. Concluyese ser necesarias acciones educativas para efectivamente producir la reducción de las alteraciones antes de todo entre mujeres más jóvenes. Abstract in english The aim of the present study was to verify the occurrence of citopathological alterations and risk factors of Uterine Cervical Neoplasm in women attended by SUS - the Public Healthcare System - in a district situated in the North of Paraná State, Brazil from 2001 to 2006. It was a descriptive transversal observational study. The data collection consisted in collection of test results from medical records and interviews. It was achieved 6.356 tests and, 1.02% (65) of the (more) women examined presented alterations. From the tests made 4.869 (70,8%) were from women aged between 25 and 59 years. And 38,5% of the tests presented Cervical Intraepithelial Neoplasm (CIN) I, 32,3% CIN II, 18,5% CIN I and Human Papiloma Virus (HPV). It was interviewed 25 women from the total sample. Most of them presented a risk factor as: smoking habits, sexually transmitted diseases, use of hormonal contraceptive, number of sexual partners, early sexual intercourse. This study concludes that is required educative and more effective actions in order to reduce the alterations, meanly among teenagers.

Melo, Simone Cristina Castanho Sabaini de; Prates, Letícia; Carvalho, Maria Dalva de Barros; Marcon, Sonia Silva; Pelloso, Sandra Marisa

2009-12-01

233

Alterações citopatológicas e fatores de risco para a ocorrência do câncer de colo uterino Alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero Citopathological alterations and risk factors for uterine cervical neoplasm  

Directory of Open Access Journals (Sweden)

Full Text Available O objetivo do estudo foi verificar alterações citopatológicas e fatores de risco para o câncer de colo uterino em mulheres usuárias do Sistema Único de Saúde de um município de pequeno porte do norte do Paraná, de 2001 a 2006. Trata-se de um estudo observacional transversal descritivo. A coleta de dados foi realizada com os resultados dos exames, prontuários e entrevistas. Foram realizados 6.356 exames e 65(1,02%) apresentaram alterações. Dos exames realizados, 4.869 (70,8%) foram em mulheres de 25 a 59 anos. 38,5% dos exames apresentaram Neoplasia Intraepitelial Cervical (NIC) I, 32,3% NIC II e 18,5% NIC I e Papiloma Vírus Humano (HPV). Foram entrevistadas 25 mulheres, a maioria apresentou algum fator de risco como: tabagismo, doenças sexualmente transmissíveis, uso de anticoncepcional hormonal, número de parceiros, início precoce da atividade sexual. Conclui-se pela necessidade de ações educativas mais efetivas no sentido de reduzir as alterações principalmente entre as mulheres adolescentes.El objetivo del estudio fue verificar alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero en mujeres atendidas por el Sistema Único de la Salud de una ciudad de pequeño porte en la Región Norte de la Provincia del Paraná, Brasil en el período de 2001 al 2006. Se trata de un estudio observacional transversal descriptivo. La colección de los datos fue realizada con los resultados de los exámenes, prontuarios y entrevistas. Fueron realizados 6.356 exámenes y 65(1,02%) presentaron alteraciones. De los exámenes hechos 4.869 (70,8%) fue compuesto de mujeres con edad entre los 25 a los 59 años. Un total de 38,5% de los exámenes presentaron Neoplasia Intra-epitelial del Cuello Uterino (NIC) I, 32,3% NIC II y 18,5% NIC I y Virus de Papiloma Humano (HPV). Fueron entrevistadas 25 mujeres, la mayoría presentó factores de riesgo como: tabaquismo, enfermedades de transmisión sexual, uso de anticonceptivo hormonal, número de parejas sexuales, inicio precoz de la actividad sexual. Concluyese ser necesarias acciones educativas para efectivamente producir la reducción de las alteraciones antes de todo entre mujeres más jóvenes.The aim of the present study was to verify the occurrence of citopathological alterations and risk factors of Uterine Cervical Neoplasm in women attended by SUS - the Public Healthcare System - in a district situated in the North of Paraná State, Brazil from 2001 to 2006. It was a descriptive transversal observational study. The data collection consisted in collection of test results from medical records and interviews. It was achieved 6.356 tests and, 1.02% (65) of the women examined presented alterations. From the tests made 4.869 (70,8%) were from women aged between 25 and 59 years. And 38,5% of the tests presented Cervical Intraepithelial Neoplasm (CIN) I, 32,3% CIN II, 18,5% CIN I and Human Papiloma Virus (HPV). It was interviewed 25 women from the total sample. Most of them presented a risk factor as: smoking habits, sexually transmitted diseases, use of hormonal contraceptive, number of sexual partners, early sexual intercourse. This study concludes that is required educative and more effective actions in order to reduce the alterations, meanly among teenagers.

Simone Cristina Castanho Sabaini de Melo; Letícia Prates; Maria Dalva de Barros Carvalho; Sonia Silva Marcon; Sandra Marisa Pelloso

2009-01-01

234

Análise de um programa municipal de prevenção do câncer cérvico-uterino Análisis de un programa municipal de prevención del cáncer del cuello uterino Analysis of a municipal program of uterine cervical neoplasm prevention  

Directory of Open Access Journals (Sweden)

Full Text Available Trata-se de um estudo descritivo-exploratório com objetivo de analisar o programa de prevenção do câncer cérvico uterino no município de Igarapava/SP. No ano de 2006, a rede pública municipal realizou uma cobertura de 14,9% da população feminina na faixa etária de 25 a 59 anos, metade da razão mínima esperada para os municípios, sendo a faixa etária predominante das coletas de 20 a 34 anos (43,2%). Um total de 6,3% não compareceu no serviço de saúde a fim de receber o resultado. Quanto aos resultados das coletas, 51.6% (774) estavam dentro dos limites de normalidade e 47,9% (719) apresentaram alguma alteração, sendo 0,1% compatível com NIC II e III.Se trata de un estudio descriptivo-exploratorio con el objetivo de análisar el programa de prevención del cáncer del cuello uterino en el distrito municipal de Igarapava/SP. En el año de 2006, la red pública municipal realizó una cobertura de 14,9% de la población femenina en la faja de edad de 25 a 59 años, la mitad de la razón mínima esperada para los distritos municipales, siendo la faja de edad predominante de las colecciones de 20 a 34 años (43,2%). Un total de 6,3% no asistió en el servicio de salud para recibir el resultado. En cuanto a los resultados de las colecciones, 51,6% (774) de ellos estaban dentro de los límites de normalidad y 47,9% (719) de ellos presentaron alguna alteración, mientras siendo 0,1% compatible con NIC II e III.This is a descriptive-exploratory study that aimed at analysing the program of uterine cervical neoplasm prevention in the city of Igarapava/SP. In the year of 2006, the municipal public service realized a preventive program with 14.9% of the feminine population from 25 to 59 years old, half of the minimum expected for the cities, whereas the predominant age of those colleted were of 20 to 34 years old (43.2%). A total of 6.3% did not show up at the public health centers in order to get the results. Regarding the results of the collecting, 51.6% (774) were within the limits of normality and 47.9% (719) presented some alteration, where 0.1% were compatible with CIN I and II.

Maurícia Brochado Oliveira Soares; Sueli Riul da Silva

2010-01-01

235

Erosion Basics  

Science.gov (United States)

This homepage of Dr. Richard A. McLaughlin at North Carolina State University includes a four-part tutorial about soil erosion and mitigation. Slide presentations include an introduction to the factors that lead to soil erosion, a general discussion of soil characteristics and susceptibility to erosion, an overview of the formation of rills and gullies, and some examples of sediment transport dynamics and erosion reduction techniques. The site also features short videos that show tests of erosion control methods in an artificial environment.

Mclaughlin, Richard A.; University, North C.

236

Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix.  

UK PubMed Central (United Kingdom)

Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59-year-old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor.

Kuroda N; Wada Y; Inoue K; Ohara M; Mizuno K; Toi M; Tanaka A; Wani Y; Yanai H

2013-07-01

237

Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix.  

Science.gov (United States)

Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59-year-old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor. PMID:21987295

Kuroda, Naoto; Wada, Yukari; Inoue, Kaori; Ohara, Masahiko; Mizuno, Keiko; Toi, Makoto; Tanaka, Azusa; Wani, Yoji; Yanai, Hiroyuki

2011-10-11

238

Extreme cervical elongation after sacrohysteropexy.  

UK PubMed Central (United Kingdom)

We present a case of extreme cervical elongation with a cervix of 12 cm after an unusual operation in which the uterine corpus was directly fixed to the promontory, and which became symptomatic after 8 years. The possible pathophysiology of cervical elongation is discussed. Diagnosing a case of severe cervical elongation can be important in the pre-operative evaluation. It can alter the operative plan to a uterus-sparing technique or it can alert the surgeon to a difficult entry in the abdominal cavity during vaginal hysterectomy.

Vierhout ME; Fütterer JJ

2013-09-01

239

Primary malignant lymphoma of the uterine cervix.  

Science.gov (United States)

Primary malignant lymphoma of the female genital tract is an extremely rare clinical entity. We report a case of primary non-Hodgkin lymphoma of the uterine cervix. An 85-year-old woman presented with abnormal genital bleeding. A colposcopic examination revealed a mass in the uterine cervix. No other lesions were detected by the whole-body CT, gallium scintigraphy and bone marrow examination. The histological examination and immunohistochemical staining of the cervical biopsy material confirmed a diagnosis of diffuse large B cell lymphoma of the uterine cervix, clinical stage 1E (according to the Ann Arbor Staging Classification for Lymphomas). The patient was treated with rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine (oncovin) and prednisone. Her family refused surgery and involved field irradiation. She was in good condition but after 5 months she expired due to myocardial infarction. PMID:23008373

Binesh, Fariba; Karimi zarchi, Mojgan; Vahedian, Hasanali; Rajabzadeh, Yavar

2012-09-24

240

Primary malignant lymphoma of the uterine cervix.  

UK PubMed Central (United Kingdom)

Primary malignant lymphoma of the female genital tract is an extremely rare clinical entity. We report a case of primary non-Hodgkin lymphoma of the uterine cervix. An 85-year-old woman presented with abnormal genital bleeding. A colposcopic examination revealed a mass in the uterine cervix. No other lesions were detected by the whole-body CT, gallium scintigraphy and bone marrow examination. The histological examination and immunohistochemical staining of the cervical biopsy material confirmed a diagnosis of diffuse large B cell lymphoma of the uterine cervix, clinical stage 1E (according to the Ann Arbor Staging Classification for Lymphomas). The patient was treated with rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine (oncovin) and prednisone. Her family refused surgery and involved field irradiation. She was in good condition but after 5 months she expired due to myocardial infarction.

Binesh F; Karimi zarchi M; Vahedian H; Rajabzadeh Y

2012-01-01

 
 
 
 
241

Oxytocin induced second trimester uterine rupture.  

UK PubMed Central (United Kingdom)

A case of oxytocin induced rupture of an unscarred uterus during the second trimester is presented. While rupture of the uterus by oxytocic agents in the second trimester has previously been documented, this case is unusual in that fetal parts were palpable through the cervical os, delaying diagnosis and definitive management. Digital palpation of fetal parts through the cervix does not preclude the diagnosis of fetal extrusion secondary to uterine rupture.

Dickinson JE; Newnham JP; Roberts RV; Reid SE

1986-11-01

242

Effect of the estrous cycle on uterine infection induced by Escherichia coli.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Escherichia coli was inoculated into the uterine lumen of rats and rabbits at different estrous stages; one uterine horn of each animal was ligated at the cervical end. In rats, a large number of E. coli were retained in the ligated horns regardless of the estrous stage. E. coli inoculated at diestr...

Nishikawa, Y; Baba, T; Imori, T

243

Uterine artery embolization - discharge  

Science.gov (United States)

Uterine fibroid embolization - discharge; UFE - discharge; UAE - discharge ... You had uterine artery embolization (UAE). UAE is a procedure to treat fibroids using radiology instead of surgery. During the procedure, the blood supply of the fibroids ...

244

Cervical Adenocarcinoma  

Science.gov (United States)

... about 15 to 20 percent of all cervical cancers. Cervical adenocarcinoma arises within glands located in the endocervix. ... order to assist in making treatment decisions. Cervical Cancer Cervical Adenocarcinoma Copyright © 2011. College of American Pathologists. For ...

245

Erosion mechanisms  

Energy Technology Data Exchange (ETDEWEB)

Several, apparently dominant, mechanisms of hot gas flow propellant combustion erosion have been isolated and partially evaluated during the course of investigations over the past four years. Several of the more distinctly isolatable mechanisms are described. Some notions are presented on techniques for countering the type of container wall erosion which generally occurs in internal combustion gas flows emanating from solid propellant hypergolic combustion.

Buckingham, A.C.; Siekhaus, W.J.; Price, C.W.

1982-07-12

246

Modification of conservative treatment of heterotopic cervical pregnancy by Foley catheter balloon fixation with cerclage sutures at the level of the external cervical os: a case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Introduction Conservative treatment of a heterotopic cervical pregnancy was performed with a modification of the fixation of a Foley catheter at the level of the external cervical os, followed by the ligature of the descending cervical branches of the uterine arteries and s...

Hafner Tomislav; Ivkosic Ivana; Serman Alan; Bauman Renato; Ujevic Boris; Vujisic Sanja; Hafner Daria; Miskovic Berivoj

247

Advanced uterine manipulation technologies.  

UK PubMed Central (United Kingdom)

As the number of conventional laparoscopic and robot-assisted gynecologic surgeries continues to rise, efficient and safe uterine manipulation has become increasingly important. Currently described uterine manipulation techniques require constant manual manipulation by the surgeon or surgical assistant. This often necessitates extra operating room personnel, increases fatigue levels, and decreases efficiency. There are two new uterine manipulation devices that can improve these measures: the Uterine Positioning System® (UPS) (Cooper Surgical, Trumbull, CT) and the ViKY UP® "Vision Control for endoscopY" Uterine Positioner (EndoControl Medical, La Tronche, France). Both provide accurate and secure uterine positioning. The UPS can manipulate the uterus with minimal bedside involvement from the surgical team while the ViKY UP provides uterine manipulation through a robotic arm controlled by the surgeon remotely. These two devices can facilitate a multitude of conventional laparoscopic and robot-assisted gynecologic surgeries.

Swan K; Kim J; Advincula AP

2010-10-01

248

Advanced uterine manipulation technologies.  

Science.gov (United States)

As the number of conventional laparoscopic and robot-assisted gynecologic surgeries continues to rise, efficient and safe uterine manipulation has become increasingly important. Currently described uterine manipulation techniques require constant manual manipulation by the surgeon or surgical assistant. This often necessitates extra operating room personnel, increases fatigue levels, and decreases efficiency. There are two new uterine manipulation devices that can improve these measures: the Uterine Positioning System® (UPS) (Cooper Surgical, Trumbull, CT) and the ViKY UP® "Vision Control for endoscopY" Uterine Positioner (EndoControl Medical, La Tronche, France). Both provide accurate and secure uterine positioning. The UPS can manipulate the uterus with minimal bedside involvement from the surgical team while the ViKY UP provides uterine manipulation through a robotic arm controlled by the surgeon remotely. These two devices can facilitate a multitude of conventional laparoscopic and robot-assisted gynecologic surgeries. PMID:21082569

Swan, Kimberly; Kim, John; Advincula, Arnold P

2010-10-01

249

Second trimester medical abortion in a woman with prior classical caesarean section and a uterine leiomyoma - A case report.  

UK PubMed Central (United Kingdom)

Abstract Background Medical abortion in women with the scar of a classical caesarean section (CS) and a large uterine leiomyoma is rarely attempted; it carries the risk of uterine rupture and haemorrhage. Case A 34-year-old multiparous woman with prior classical CS and a 14 × 10 × 9 cm leiomyoma arising from the uterine isthmus had an induced abortion at 14 weeks' gestation. Mechanical cervical priming with Dilapan(®)-S followed by vaginal misoprostol administration resulted in the uncomplicated expulsion of the uterine contents. Conclusions An early second trimester medical abortion with misoprostol was successfully performed in a woman with prior classical CS and a large uterine leiomyoma.

Seto MT; Ngu SF; Cheung VY; Pun TC

2013-10-01

250

Second trimester medical abortion in a woman with prior classical caesarean section and a uterine leiomyoma - A case report.  

Science.gov (United States)

Abstract Background Medical abortion in women with the scar of a classical caesarean section (CS) and a large uterine leiomyoma is rarely attempted; it carries the risk of uterine rupture and haemorrhage. Case A 34-year-old multiparous woman with prior classical CS and a 14 × 10 × 9 cm leiomyoma arising from the uterine isthmus had an induced abortion at 14 weeks' gestation. Mechanical cervical priming with Dilapan(®)-S followed by vaginal misoprostol administration resulted in the uncomplicated expulsion of the uterine contents. Conclusions An early second trimester medical abortion with misoprostol was successfully performed in a woman with prior classical CS and a large uterine leiomyoma. PMID:23692523

Seto, Mimi T Y; Ngu, Siew-Fei; Cheung, Vincent Y T; Pun, Ting-Chung

2013-05-22

251

Strategy for laparoscopic cervical myomectomy.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Myoma of the uterine cervix is rare, accounting for about 5% of all myomas. Compared with myomas that occur in the uterine corpus, cervical myomas are closer to other organs such as the bladder, ureter, and rectum, and the approach needs to be modified because the organs that have to be considered differ depending on the location of the myoma. We divided cervical myomas into 2 types according to location, comprising an intracervical type and extracervical types. A clear outline of surgical treatment for cervical myoma has not described in previous papers. We then investigated the surgical strategy for these types. PATIENTS: Subjects comprised 16 patients who were diagnosed with cervical myoma in our hospital between January 2005 and April 2009, and who underwent laparoscopic myomectomy. RESULT: Mean operative time was 105.8 + or - 43.2 (82.8-128.8) min, mean blood loss was 105 + or - 117 (42.6-167.4) ml, and mean specimen weight was 208.3 + or - 195.4 (99.3-306.2) g. Histopathological examination showed atypical myoma in 1 case and leiomyoma in others. CONCLUSIONS: 16 cases of cervical myomectomy were performed safely by developing a uniform strategy that uses a fixed operative procedure, even with laparotomy, if sufficient attention is paid to the following 6 points: 1) attempting to reduce the size of the myoma with the use of preoperative GnRH; 2) determining the positional relationship between the myoma and surrounding organs; 3) temporarily blocking uterine artery blood flow with the use of vessel clips; 4) suppressing bleeding during myomectomy with the use of vasopressin; 5) minimizing the risk of damaging surrounding organs by positioning the incision in the myometrium somewhat lateral to the uterine corpus; and 6) the bottom of the wound after enculation should be pulled up by the forceps for suturing to avoid making dead space.

Matsuoka S; Kikuchi I; Kitade M; Kumakiri J; Kuroda K; Tokita S; Kuroda M; Takeda S

2010-05-01

252

Definition of compartment-based radical surgery in uterine cancer: radical hysterectomy in cervical cancer as 'total mesometrial resection (TMMR)' by M H?ckel translated to robotic surgery (rTMMR)  

Science.gov (United States)

Background Radical hysterectomy has been developed as a standard treatment in Stage I and II cervical cancers with and without adjuvant therapy. However, there have been several attempts to standardize the technique of radical hysterectomy required for different tumor extension with variable success. Total mesometrial resection as ontogenetic compartment-based oncologic surgery - developed by open surgery - can be standardized identically for all patients with locally defined tumors. It appears to be promising for patients in terms of radicalness as well as complication rates. Robotic surgery may additionally reduce morbidity compared to open surgery. We describe robotically assisted total mesometrial resection (rTMMR) step by step in cervical cancer and present feasibility data from 26 patients. Methods Patients (n = 26) with the diagnosis of cervical cancer were included. Patients were treated by robotic total mesometrial resection (rTMMR) and pelvic or pelvic/periaortic robotic therapeutic lymphadenectomy (rtLNE) for FIGO stage IA-IIB cervical cancer. Results No transition to open surgery was necessary. No intraoperative complications were noted. The postoperative complication rate was 23%. Within follow-up time (mean: 18 months) we noted one distant but no locoregional recurrence of cervical cancer. There were no deaths from cervical cancer during the observation period. Conclusions We conclude that rTMMR and rtLNE is a feasible and safe technique for the treatment of compartment-defined cervical cancer.

2013-01-01

253

High signals in the uterine cervix on T2-weighted MRI sequences  

International Nuclear Information System (INIS)

The aim of this pictorial review was to illustrate the normal cervix appearance on T2-weighted images, and give a review of common or less common disorders of the uterine cervix that appear as high signal intensity lesions on T2-weighted sequences. Numerous aetiologies dominated by cervical cancer are reviewed and discussed. This gamut is obviously incomplete; however, radiologists who perform MR women's imaging should perform T2-weighted sequences in the sagittal plane regardless of the indication for pelvic MR. Those sequences will diagnose some previously unknown cervical cancers as well as many other unknown cervical or uterine lesions. (orig.)

2003-01-01

254

Progesterone receptor in the human uterine cervix.  

Directory of Open Access Journals (Sweden)

Full Text Available A progesterone receptor (PR) in human uterine cervical nuclei was demonstrated by a nuclear exchange assay using a synthetic progestin, promegestone (R5020) as a radio-labeled ligand. Total exchange of previously bound progesterone with R5020 was achieved by incubation at 0 degree C for 3 h. A 0.6 M KCl solution was used to extract the nuclear PR in uterine cervical tissue, and the dextran coated charcoal (DCC) method was used to separate the free [3H] R5020 from the bound form. Scatchard plots of nuclear PR binding showed two components with dissociation constants of Kd = 2.3 X 10(-10) and 4.6 X 10(-9) M. Three histological regions of the uterine cervix was studied as to their nuclear PR contents throughout the menstrual cycle. In the follicular phase, the connective tissue (CT) had the highest PR concentration (658.9 fmole/mg DNA), followed by the columnar epithelium (CE) (253.6 fmole/mg DNA), and the squamous epithelium (SE) (184.7 fmole/mg DNA). In the luteal phase, there was no significant difference among the three regions. Comparing these phases of cycle revealed that the CT had higher PR contents in the follicular phase than in the luteal phase, but no such difference was found in the CE or SE. These three regions had the same Kd value in both phases.

Lin,Tai-Tung

1984-01-01

255

Modification of conservative treatment of heterotopic cervical pregnancy by Foley catheter balloon fixation with cerclage sutures at the level of the external cervical os: a case report  

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Full Text Available Abstract Introduction Conservative treatment of a heterotopic cervical pregnancy was performed with a modification of the fixation of a Foley catheter at the level of the external cervical os, followed by the ligature of the descending cervical branches of the uterine arteries and systemic methotrexate application. Case presentation A 34-year-old Caucasian woman was diagnosed with double gestation after 6 weeks of in vitro fertilization treatment. A gynecological examination and color Doppler ultrasound scan revealed intra-uterine and cervical gestational sacs both containing live fetuses. A Foley catheter balloon was inserted into the cervical canal, inflated and fixed by a cerclage suture at the level of the external cervical os, followed by ligation of the descending cervical branches of the uterine arteries. Systemic methotrexate was applied. Three days after removal of the Foley catheter, an evacuation of the intra-uterine gestational sac was performed. Hemorrhage from the implantation site was controlled immediately and a pregnancy termination was successfully performed. The procedure was uneventful and our patient was discharged with a preserved uterus. Conclusions Conservative treatment of cervical pregnancy using a Foley catheter balloon is more efficacious if the Foley catheter balloon is attached in the correct position with a cerclage suture at the level of the external os, followed by ligation of the descending cervical branches of the uterine arteries, thereby exerting maximal pressure on the bleeding vessels.

Hafner Tomislav; Ivkosic Ivana; Serman Alan; Bauman Renato; Ujevic Boris; Vujisic Sanja; Hafner Daria; Miskovic Berivoj

2010-01-01

256

Cyto-histopathological correlations in uterine cervix pathology  

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Full Text Available linical significant cervical lesions are often correlated with epithelial cell abnormalities on cervical smears. The histologic lesions which are found in uterine cervix can not be always established only with conventional cytology. Thus, it is very important that any cytologic abnormality be subsequently correlated with biopsy for certification of a cervical lesion. The results of cervical smears and tissue diagnoses over a five year period were reviewed, being examined the correlations between the cervico-vaginal smears and the surgical specimens. All cervical smears with their subsequent biopsies and histerectomies, between 2003-2008 were retrospectively evaluated. The patients ages were between 18 and 70 years old. The cervical cytology records were verifyied and the cytodiagnosis were compared with the correspondent histopathological diagnosis. From the 5700 cervico-vaginal smears, diagnosticated in the mentioned period of time, 3835 were negative for intraepithelial lesion or malignancy. The others of 1865 presented squamous and glandular lesions, and cervical carcinoma. One case, of a 20 years old girl, had a cytodiagnostic with suspicion of sarcoma, which was confirmed on biopsy and subsequent histerectomy as a cervical embrional rhabdomyosarcoma. The exfoliative cytologic cervico-vaginal test is very important in precocious diagnosis of intraepithelial cervical lesions, especially when it its correlated with histopathologic examination. The immunohistochemical and molecular testing of high-risk HPV will contribute to a better management of cervical precancerous lesions.

Raluca Balan; Eduard Crauciuc; Vlad Gheorghita; Maricica Pavaleanu; Ovidiu Toma; Cornelia Amalinei

2009-01-01

257

Phosphorous-31 magnetic resonance spectroscopy of cervical cancer using transvaginal surface coil  

International Nuclear Information System (INIS)

We developed a new transvaginal coil tuned for phosphorous-31 and measured its magnetic resonance spectroscopy (31P MRS) of uterine cervical cancer. In a 50-year-old woman with uterine cervical cancer (International Federation of Gynecology and Obstetrics [FIGO] stage IIIb), 31P MRS with the new coil clearly differentiated the low intensity of phosphocreatinine (PCr) and high intensity of phosphomonoester (PME) in tumor from those in muscle. Results suggests that this method will be useful for assessing uterine cervical cancer. (author)

2005-01-01

258

Pitfall in ultrasound evaluation of uterine scar from prior preterm cesarean section.  

UK PubMed Central (United Kingdom)

We report two cases of women with a previous cesarean performed before active labor at 29 weeks of gestation who underwent sonographic measurement of the lower uterine segment (LUS) at 36 weeks' gestation in their subsequent pregnancy. In both cases, uterine scar defect was detected on the upper part of the LUS, at ?9 to 11 cm from the cervical os, and was only visualized by the transabdominal approach. We suggest that early gestational age and the absence of labor at previous cesarean can lead to a higher uterine scar location on the LUS and, therefore, increase the risk of uterine rupture in subsequent pregnancy. The heterogeneity of uterine scar location could explain discrepancies observed in studies using the transabdominal versus the transvaginal approach or both regarding the predictive value of LUS measurements for uterine rupture.

Laflamme SM; Jastrow N; Girard M; Paris G; Bérubé L; Bujold E

2011-09-01

259

Malignant mixed mullerian tumor arising from the uterine cervix: A case report  

International Nuclear Information System (INIS)

[en] Malignant mixed mullerian tumors (MMMTs) are a rare uterine tumor and contribute to approximately 1-3% of all corpus malignant tumors. MMMTs are usually in the uterine corpus, but can also arise from the uterine cervix, vagina, ovaries and fallofian tubes. MMMTs of the uterine cervix are extremely rare. MMMTs are highly malignant and tend to maintain a rapid growth and exhibit a high rate of recurrence. Therefore, the prognosis of patients diagnosed with these types of tumors is extremely poor. We report a rare case of a malignant mixed mullerian tumor arising from the uterine cervix and introduce CT and MRI findings. CT and magnetic resonance findings of the uterine cervical MMMT in our case show highly aggressive features, such as parametrial involvement, pelvic and paraaortic lymphadenopathy, and distant metastasis and high enhancement

2012-01-01

260

Uterine torsion in pregnancy.  

UK PubMed Central (United Kingdom)

Torsion of the pregnant uterus is defined as rotation more than 45 degrees around the long axis of the uterus. Uterine torsion is observed in all age groups of the reproductive period, in all parity groups, and at all stages of pregnancy. Torsion from 60 degrees to 720 degrees has been described. It is not possible to clarify why uterine torsion occurs, but numerous abnormalities have appeared with uterine torsion; most often, abnormal fetal presentation, myoma uteri and uterine malformations. The most usual symptoms of uterine torsion are birth obstruction, abdominal pain, vaginal bleeding, shock, and urinary and intestinal symptoms. Eleven percent are asymptomatic. The treatment in the earlier months of pregnancy is immediate laparotomy and detorsion of the uterus and, if practicable, adjunct surgery to eliminate the possible etiologic factors. Near term or during labor cesarean section is carried out, and elimination of the possible etiologic factors. The fetal and maternal mortality rates since 1976 are 12% and 0% respectively.

Jensen JG

1992-05-01

 
 
 
 
261

Malignant mullerian mixed tumor of the uterine cervix with a small cell neuroendocrine carcinoma component.  

UK PubMed Central (United Kingdom)

Malignant Müllerian mixed tumors (MMMTs) of the uterine cervix are extremely rare, accounting for 0.005% of all cervical malignancies. To date, only approximately 50 well-documented cases have been reported. Although several epithelial components have been described in cervical MMMTs, small cell neuroendocrine carcinoma (SCC) has not appeared in the English literature. We present a 43-year-old woman, para 2 gravida 2, who had MMMT with SCC and rhabdomyosarcoma components in the uterine cervix. She was referred to our hospital because of a cervical mass with an abnormal Pap smear result. Cervical biopsy revealed SCC. After neoadjuvant chemotherapy with balloon-occluded arterial infusion, she underwent type II radical hysterectomy with pelvic lymphadenectomy. Histological analysis revealed that the cervical tumor comprised SCC and rhabdomyosarcoma components. Genotype analysis indicated human papillomavirus type 18. She underwent concurrent chemoradiation therapy. The patient had been free of the disease and showed no evidence of recurrence 38 months after operation.

Munakata S; Iwai E; Tanaka T; Nakamura M; Kanda T

2013-01-01

262

Uterine amulets and Greek uterine medicine.  

Science.gov (United States)

This article publishes for the first time a hematite uterine amulet in the author's possession. After a brief look at this amulet I offer a summary of previous scholarship on uterine amulets, and then focus on three specific aspects -the amulets' relation to Greek medical texts on gynecological topics; evidence for the use of perishable and non-perishable amulets by Greek women prior to the proliferation of the hematite examples in the Roman period (ca. II CE). I conclude with a discussion of the derivation and meaning of ororiouth, based on my correspondence with Dr. Roy Kotansky. PMID:11623421

Hanson, A E

1995-01-01

263

Uterine amulets and Greek uterine medicine.  

UK PubMed Central (United Kingdom)

This article publishes for the first time a hematite uterine amulet in the author's possession. After a brief look at this amulet I offer a summary of previous scholarship on uterine amulets, and then focus on three specific aspects -the amulets' relation to Greek medical texts on gynecological topics; evidence for the use of perishable and non-perishable amulets by Greek women prior to the proliferation of the hematite examples in the Roman period (ca. II CE). I conclude with a discussion of the derivation and meaning of ororiouth, based on my correspondence with Dr. Roy Kotansky.

Hanson AE

1995-01-01

264

[Case of atypical polypoid adenomyoma of the uterine cevix].  

UK PubMed Central (United Kingdom)

Atypical polypoid adenomyoma (APA) is a rare benign polypoid tumor occuring in young reproductive age women. There are no specific clinical features of APA. Grossly the tumor presents as a small polypoid lession in the low uterin cavum segment and cervical canal, mimicring infiltative endocervical or endometrial carcinoma. Microscopicaly APA consists of irregular glands, as endometrial with mild cellular atypia and diffuse smooth-mussle stroma. We present a case of APA of the uterine cervix in a young woman in regard to the diagnostical and treatment obstacles usually accompaning this rare pathology.

Bachurska S; Yamakov K; Belovezdov V; Staykov D; Pehlivanov B

2013-01-01

265

Recurrent uterine rupture after hysterescopic resection of the uterine septum.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Uterine rupture after hysteroscopic septum resection is a rare complication, and its frequency is reported to be approximately 1-2.7%. Uterine perforation and monopolar resection during hysteroscopy are well-known risk factors for subsequent uterine rupture during pregnancy. PRESENTATION OF CASE: We present a case of recurrent uterine ruptures during consecutive pregnancies in a patient who had undergone hysteroscopic septum resection for recurrent pregnancy loss. DISCUSSION: Recurrent uterine rupture due to hysteroscopic septum resection in pregnancy is a very rare condition. In the present case we noted that the first two uterine ruptures resulted from uterine contractions; however, the third rupture occurred spontaneously and earlier in gestation. As each uterine rupture occurred earlier than the rupture in the previous gestation, a history of uterine rupture during pregnancy should raise provider suspicion about the possibility of earlier uterine rupture recurrence. CONCLUSION: Uterine rupture may occur in pregnancies after hysteroscopic resection of the uterine septum. However, if a patient has a history of uterine rupture during previous pregnancies, the risk of uterine rupture may increase for earlier gestational ages in subsequent pregnancies. The patient must be informed about both the risks of uterine rupture during pregnancy after hysteroscopic septum resection and that recurrent ruptures may occur at earlier gestational weeks than during previous pregnancies.

Ergenoglu M; Yeniel AO; Y?ld?r?m N; Akdemir A; Yucebilgin S

2013-01-01

266

Uterine cervical carcinoma: a comparison of two- and three-dimensional T2-weighted turbo spin-echo MR imaging at 3.0 T for image quality and local-regional staging.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To compare three-dimensional (3D) T2-weighted turbo spin-echo (TSE) with multiplanar two-dimensional (2D) T2-weighted TSE for the evaluation of invasive cervical carcinoma. METHODS: Seventy-five patients with cervical carcinoma underwent MRI of the pelvis at 3.0 T, using both 5-mm-thick multiplanar 2D (total acquisition time?=?12 min 25 s) and 1-mm-thick coronal 3D T2-weighted TSE sequences (7 min 20 s). Quantitative analysis of signal-to-noise ratio (SNR) and qualitative analysis of image quality were performed. Local-regional staging was performed in 45 patients who underwent radical hysterectomy. RESULTS: The estimated SNR of cervical carcinoma and the relative tumour contrast were significantly higher on 3D imaging (P?cervical carcinoma with a shorter MR data acquisition, but has limitations with regard to the sharpness of the tumour margin.

Shin YR; Rha SE; Choi BG; Oh SN; Park MY; Byun JY

2013-04-01

267

Inactivation of SLIT2-ROBO1/2 Pathway in Premalignant Lesions of Uterine Cervix: Clinical and Prognostic Significances  

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The SLIT2-ROBO1/2 pathways control diverse biological processes, including growth regulation. To understand the role of SLIT2 and ROBO1/2 in cervical carcinogenesis, firstly their RNA expression profiles were screened in 21 primary uterine cervical carcinoma (CACX) samples and two CACX cell lines. H...

Mitra, Sraboni; Mazumder-Indra, Dipanjana; Mondal, Ranajit K.; Basu, Partha S.; Roy, Anup; Roychoudhury, Susanta

268

Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia/ The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia  

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Full Text Available Abstract in spanish Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron entrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de cit (more) ología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %), 36 citología anormal (2 %) y 638 cambios celulares reactivos asociados a inflamación (37 %). Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país. Abstract in english Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire to collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and cl (more) assification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %), 36 abnormal cytology (2 %) and 638 reactive cellular changes associated with inflammation (37 %). The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

Tafurt-Cardona, Yaliana; Acosta-Astaiza, Claudia P.; Sierra-Torres, Carlos H.

2012-02-01

269

Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia  

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Full Text Available Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron entrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %), 36 citología anormal (2 %) y 638 cambios celulares reactivos asociados a inflamación (37 %). Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país.Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire to collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %), 36 abnormal cytology (2 %) and 638 reactive cellular changes associated with inflammation (37 %). The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

Yaliana Tafurt-Cardona; Claudia P Acosta-Astaiza; Carlos H Sierra-Torres

2012-01-01

270

Uterine Didelphys with blind hemivagina, hematocolpos, ipsilateral renal agenesis (UD-BHRA) and bilateral ovarian tumors : a case report  

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Uterine didelphys is a congenital malformation characterized by the presence of two separated hemiuteri and hemivaginas, due to lack of midfusion of the mullerian ducts. We report a case of UD-BHRA (uterine didelphys with blind hemivagina and ipsilateral renal agencies), a rare type of uterine dedelphys characterized by symptomatic unilateral hematocolpos due to blind hemivagina after menarche and ipsilateral renal agenesis. The MRI findings in 22-year-old woman with bilateral ovarian tumors demonstrated two separated uterine horns and cervical and vaginal canals, with left hematocolpos and left agenesis. (author). 7 refs., 1 fig.

Lee, Young Rae; Choi, Byung Ik; Park, Hae Won; Kook, Shin Ho [Kangbuk Samsung Hospital, Seoul (Korea, Republic of)

1998-03-01

271

Uterine Fibroid Embolization  

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Full Text Available ... Cardiac and Vascular Institute, we've performed almost 1,000 uterine fibroid embolizations. Fibroids are common, benign ... embolization procedure. More contrast, please. Thanks, Dr. Powell. One thing I did want to mention. You heard ...

272

Uterine Sarcoma (PDQ): Treatment  

Science.gov (United States)

... diagnose, stage, and treat uterine sarcoma: Laparotomy : A surgical procedure in which an incision (cut) is made in ... check for cancer cells. Total abdominal hysterectomy : A surgical procedure to remove the uterus and cervix through a ...

273

Awareness of general and personal risk factors for uterine cancer among healthy women.  

Science.gov (United States)

Participation rates in gynaecological cancer screening are influenced by different factors. The knowledge of general and personal risk factors for uterine cancer among women might influence their interest in gynaecological cancer screening. Two thousand nine hundred women in 23 gynaecological outpatient services were invited to answer a structured questionnaire regarding general and personal risk factors for cervical and endometrial carcinoma; 2108 women participated. Women with a history of cancer were excluded from the study. It was found that levels of knowledge about uterine carcinoma were low. Only 47.4% of women knew the difference between the sites of origin of cervical and endometrial cancer. Seventy-seven per cent of participants assessed their knowledge about uterine malignancies as insufficient; 96.3% would appreciate more information about uterine cancer. Younger women were significantly less well informed than postmenopausal women. Known risk factors such as smoking or human papillomavirus (HPV) infection as factors for cervical cancer were underestimated; most women assessed genetic factors as most important for the development of uterine cancer. The level of information about risk factors as well as general facts about gynaecological cancer in women is low. Ameliorating this lack of information might influence the perception of uterine cancer and result in higher participation rates in gynaecological cancer screening. PMID:16284496

Ackermann, Sven; Renner, Stefan Peter; Fasching, Peter Anton; Poehls, Uwe; Bender, Hans Georg; Beckmann, Mathias Wilhelm

2005-12-01

274

Hysteroscopy in evaluation of abnormal uterine bleeding.  

UK PubMed Central (United Kingdom)

UNLABELLED: One-third of all gynaecological consultations are because of abnormal uterine bleeding (AUB). This proportion rises to more than 2/3rd when peri & post menopausal women are considered. In normal to 12 week size uteri, the cause of abnormal bleeding often remains obscure. OBJECTIVES (S): Clinical and hysteroscopic evaluation of the cervical canal & uterine cavity of 100 women with AUB to evaluate various causes of AUB in the study population. METHOD (S): 100 women with AUB and uterine size normal to 12 weeks pregnancy were subjected to clinical & hysteroscopic examination. The cause of bleeding was evaluated. RESULTS: Menorrhagia (30%), menometrorrhagia (16%), oligomenorrhea (16%) and postmenopausal bleeding (2%) were some of the indications for hysteroscopy. Intrauterine pathology was diagnosed in 74% of cases. Hyperplastic endometrium (30%) and mucus polypi (28%) were the most frequent findings. 13% of the cases had multiple finding. A surprising 7% had IUCD in their uteri without their knowledge, while bony spicules was found in 1 patient. Both patients with post menopausal bleeding had atrophic endometrium. CONCLUSION (S): Hysteroscopy can be easily learnt. It gives a clue to diagnosis in AUB and can reduce the burden of hysterectomy in many cases which can be treated by simple procedures.

Guin G; Sandhu SK; Lele A; Khare S

2011-10-01

275

New type of applicator for carcinoma of the uterine cervix  

International Nuclear Information System (INIS)

Three types of applicators (TAO type, Ganken type and Henshke type) for intracavitary radiotherapy for cancer of the uterine cervix have been used in Japan. An average age of patients with cervical cancer has been increasing, and in the elderly patients with the small vagina, it would be difficult to insert these, relatively large applicators. Two types of new applicators have been made for these patients. One is a disposable type and another is a revolver type. With these applicators, intracavitary radiotherapy for the cervical cancer in the elderly patients is performed with ease. (author).

1992-01-01

276

[Advanced uterine prolapse during pregnancy: pre- and postnatal management].  

UK PubMed Central (United Kingdom)

Pelvic organ prolapse is a common pelvic floor disorder in postmenopausal women. The literature is quite poor concerning the management of prolapse during pregnancy in young women. We report the case of a 39-year-old multiparous woman referred for the treatment of an exteriorized uterine prolapse at 13 weeks of gestation. The management of cervical prolapse depends on its stage, its evolution and on gestational age. It combines local antiseptics, rest and manual reintegration or reduction of the prolapsus using a pessary to prevent ulceration of the cervix. In case of stage IV (POP-Q) uterine prolapse, vaginal delivery may be compromised. No recommendation is actually available about route of delivery in case of exteriorized uterine prolapse. It should be clearly discussed regarding the potential risk of cesarean section for dystocia. Surgical repair of the prolapse will be discussed after childbirth according to functional impairment and women's desire for pregnancy.

Pizzoferrato AC; Bui C; Fauconnier A; Bader G

2013-07-01

277

Cervical Dystonia  

Science.gov (United States)

... even infancy, cervical dystonia most often occurs in middle-aged people, women more than men. Symptoms generally begin ... the shoulder or face. However, cervical dystonia in middle age does not expand to wide areas of the ...

278

Cervical Cap  

Science.gov (United States)

Cervical cap Basics In-Depth Multimedia Resources Reprints A single copy of this article may be reprinted for personal, noncommercial use only. Cervical cap By Mayo Clinic staff Original Article: http://www. ...

279

Cervical Spine  

Science.gov (United States)

... style'); } } Share with AANS Connect Tweet Patient Information Cervical Spine February, 2006 Your neck is part of a ... which extends through most of your body. The cervical spine (neck region) consists of seven bones (C1-C7 ...

280

Avaliação da medida do comprimento do colo e da ausência do eco glandular endocervical para predição do parto pré-termo/ Evaluation of risk for preterm delivery by measurement of uterine cervix and cervical gland area  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVO: verificar a prevalência do sinal eco glandular endocervical (EGE) e o comprimento cervical menor ou igual a 20 mm em gestantes entre a 21ª e a 24ª semana e comparar estes sinais ecográficos como fatores indicadores de parto pré-termo espontâneo. MÉTODOS: estudo prospectivo transversal no qual foram incluídas 361 gestantes da população geral, para realização de exame ultra-sonografico em idade gestacional entre a 21ª a 24ª semana. Os critérios de e (more) xclusão do estudo foram malformações müllerianas, gestações múltiplas, malformações fetais, óbito fetal, alterações da quantidade de líquido amniótico, placenta com inserção segmentar, antecedentes de cirurgia no colo uterino (conização, amputação, cerclagem) e procedimentos cirúrgicos durante a gestação. Após a realização do exame ultra-sonográfico obstétrico morfológico efetuado por via abdominal, seguiu-se o exame ecográfico por via vaginal para observação de uma faixa hipoecóica ou hiperecóica adjacente ao canal endocervical correpondente às glândulas do epitélio endocervical (EGE) e mensuração do comprimento cervical. As variáveis qualitativas são representadas por freqüência absoluta e relativa, ao passo que as variáveis quantitativas, por média, desvio-padrão, mediana e valores mínimo e máximo. A associação entre as variáveis qualitativas foi avaliada pelo teste c² ou teste exato de Fisher. Para cada variável estudada, foi calculado o risco relativo seguido do intervalo com 95% de confiança. A técnica de análise de regressão logística univariada foi utilizada para verificar, entre as variáveis estudadas, quais foram indicativas de parto pré-termo espontâneo. O nível de significância adotado foi de 95% (alfa = 5%) e descritivos (p) iguais ou inferiores a 0,05 foram considerados significantes. RESULTADOS: a incidência do parto pré-termo espontâneo foi de 5,0%. O comprimento do colo uterino revelou-se igual ou inferior a 20 mm em 3,3% da população estudada e em 27,8% das pacientes que apresentaram parto pré-termo espontâneo. A ausência do EGE foi detectada em 2,8% das pacientes estudadas e em 44,4% das pacientes que evoluíram para parto pré-termo espontâneo. A associação entre ausência do EGE e presença do colo curto revelou-se estatisticamente significante (p Abstract in english PURPOSE: to verify the prevalence of two sonographic findings, the cervical gland area (CGA) feature and the cervical length of less than 20 mm, and to compare these with the risk for premature delivery in pregnant women between 21 and 24 weeks' gestation. METHOD: this was a prospective, cross-sectional study in which 361 women were consecutively examined by transvaginal ultrasonography. Müllerian or other malformations, multiple gestations, fetal death, olygo- or polyhy (more) dramnios, marginal placenta previa, and conization, cerclage, amputation or other surgical procedures in the cervix, prior to or during pregnancy, were exclusion criteria. After the abdominal ultrasonographic morphological examination, we used transvaginal ultrasonography to measure the cervical length and to observe the presence of hyper- or hypoechoic area next to the endocervical canal, a feature characteristic of endocervical epithelium glands which is called CGA (cervical gland area). Qualitative variables are expressed as absolute and relative frequency. Quantitative variables are expressed as mean, median, standard deviation, minimum, and maximum values. Association between qualitative variables was detected by the c² test or by the Fisher exact test. For each variable, the relative risk and the 95% confidence interval (CI) were calculated. Logistic regression analysis was used to calculate the predictive values for premature delivery. Significance level was 95% (alpha = 5%), with descriptive (p) values equal or lower than 0.05 considered significant. RESULTS: spontaneous preterm delivery occurred in 5.0% of the patients. Cervical length was up to 20 mm in 3.3% of a

Pires, Claudio Rodrigues; Moron, Antonio Fernandes; Mattar, Rosiane; Kulay Júnior, Luiz

2004-04-01

 
 
 
 
281

Avaliação da medida do comprimento do colo e da ausência do eco glandular endocervical para predição do parto pré-termo Evaluation of risk for preterm delivery by measurement of uterine cervix and cervical gland area  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVO: verificar a prevalência do sinal eco glandular endocervical (EGE) e o comprimento cervical menor ou igual a 20 mm em gestantes entre a 21ª e a 24ª semana e comparar estes sinais ecográficos como fatores indicadores de parto pré-termo espontâneo. MÉTODOS: estudo prospectivo transversal no qual foram incluídas 361 gestantes da população geral, para realização de exame ultra-sonografico em idade gestacional entre a 21ª a 24ª semana. Os critérios de exclusão do estudo foram malformações müllerianas, gestações múltiplas, malformações fetais, óbito fetal, alterações da quantidade de líquido amniótico, placenta com inserção segmentar, antecedentes de cirurgia no colo uterino (conização, amputação, cerclagem) e procedimentos cirúrgicos durante a gestação. Após a realização do exame ultra-sonográfico obstétrico morfológico efetuado por via abdominal, seguiu-se o exame ecográfico por via vaginal para observação de uma faixa hipoecóica ou hiperecóica adjacente ao canal endocervical correpondente às glândulas do epitélio endocervical (EGE) e mensuração do comprimento cervical. As variáveis qualitativas são representadas por freqüência absoluta e relativa, ao passo que as variáveis quantitativas, por média, desvio-padrão, mediana e valores mínimo e máximo. A associação entre as variáveis qualitativas foi avaliada pelo teste c² ou teste exato de Fisher. Para cada variável estudada, foi calculado o risco relativo seguido do intervalo com 95% de confiança. A técnica de análise de regressão logística univariada foi utilizada para verificar, entre as variáveis estudadas, quais foram indicativas de parto pré-termo espontâneo. O nível de significância adotado foi de 95% (alfa = 5%) e descritivos (p) iguais ou inferiores a 0,05 foram considerados significantes. RESULTADOS: a incidência do parto pré-termo espontâneo foi de 5,0%. O comprimento do colo uterino revelou-se igual ou inferior a 20 mm em 3,3% da população estudada e em 27,8% das pacientes que apresentaram parto pré-termo espontâneo. A ausência do EGE foi detectada em 2,8% das pacientes estudadas e em 44,4% das pacientes que evoluíram para parto pré-termo espontâneo. A associação entre ausência do EGE e presença do colo curto revelou-se estatisticamente significante (pPURPOSE: to verify the prevalence of two sonographic findings, the cervical gland area (CGA) feature and the cervical length of less than 20 mm, and to compare these with the risk for premature delivery in pregnant women between 21 and 24 weeks' gestation. METHOD: this was a prospective, cross-sectional study in which 361 women were consecutively examined by transvaginal ultrasonography. Müllerian or other malformations, multiple gestations, fetal death, olygo- or polyhydramnios, marginal placenta previa, and conization, cerclage, amputation or other surgical procedures in the cervix, prior to or during pregnancy, were exclusion criteria. After the abdominal ultrasonographic morphological examination, we used transvaginal ultrasonography to measure the cervical length and to observe the presence of hyper- or hypoechoic area next to the endocervical canal, a feature characteristic of endocervical epithelium glands which is called CGA (cervical gland area). Qualitative variables are expressed as absolute and relative frequency. Quantitative variables are expressed as mean, median, standard deviation, minimum, and maximum values. Association between qualitative variables was detected by the c² test or by the Fisher exact test. For each variable, the relative risk and the 95% confidence interval (CI) were calculated. Logistic regression analysis was used to calculate the predictive values for premature delivery. Significance level was 95% (alpha = 5%), with descriptive (p) values equal or lower than 0.05 considered significant. RESULTS: spontaneous preterm delivery occurred in 5.0% of the patients. Cervical length was up to 20 mm in 3.3% of all studied patients and in 27.8% of those who delivered spon

Claudio Rodrigues Pires; Antonio Fernandes Moron; Rosiane Mattar; Luiz Kulay Júnior

2004-01-01

282

Importancia de los estudios de inmunohistoquímica en el diagnóstico y la evaluación pronóstica de la neoplasia intraepitelial y el cáncer cervical: Revisión/ Importance of immunohistochemical studies in the diagnosis and the prognostic evaluation of cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix: Review  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Se evaluó la expresión de proteínas dependientes de genes en el epitelio cervical, en la neoplasia intraepitelial cervical (NIC) y en el carcinoma del cuello uterino (CC) a través de diversos estudios de inmunohistoquímica (IHQ). Se examinó la detección de ciertas proteínas como p53, bcl2, C-Myc, Ki 67, Ciclinas, P16 INK4a, p21, p27, b-catenina, Wnt y MCM, en relación con la evolución de la neoplasia intraepitelial, el carcinoma cervical y la infección con el v (more) irus del papiloma humano (VPH). Se señaló como la actividad transcripcional de diversos genes provoca alteraciones de la heterocigosis y pérdida de regiones cromosómicas que influyen en la sobrexpresión de proteínas o en la pérdida parcial de la expresión de algunas glicoproteínas en la superficie celular por la activación de genes del VPH. Abstract in english Immunohistochemical studies in cervical intraepithelial neoplasia and cervical carcinoma are evaluated in this review. A variety of proteíns like p53, bcl2, C-Myc, Ki 67, Cyclines, P16 INK4a, p21, p27, b-catenin, Wnt and MCM, have been related to the development of cervical neoplasia and human papilloma virus infection. It is described how transcriptional factors of genes induce loss of heterozygosity, numerical chromosome abnormality and inactivation of gene products or the partial loss of some membrane glycoproteins induced by oncogenic human papillomaviruses (HPV).

García-Tamayo, Jorge; Molina, Julia; Blasco-Olaetxea, Eduardo

2009-06-01

283

The role of MR imaging in invasive cervical carcinoma  

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In this article the role of MR imaging in the management of cervical cancer is reviewed and illustrated. The appearance of the normal uterine cervix and of cervical carcinoma is shown. Important factors for optimal MR imaging of cervical carcinoma are reviewed. The value of MR imaging in the staging of cervical carcinoma is illustrated by showing parametrial invasion and lymph node involvement. Finally, the value of MR imaging staging is compared with clinical staging, CT staging, and surgical findings. The role of new imaging techniques, such as fast dynamic enhanced MR imaging, is described. (orig.)

Boss, E.A.; Massuger, L.F.A.G.; Boonstra, H. [Dept. of Obstetrics and Gynecology, University Hospital, Nijmegen (Netherlands); Barentsz, J.O. [Dept. of Radiology, University Hospital, Nijmegen (Netherlands)

2000-02-01

284

The role of MR imaging in invasive cervical carcinoma  

International Nuclear Information System (INIS)

In this article the role of MR imaging in the management of cervical cancer is reviewed and illustrated. The appearance of the normal uterine cervix and of cervical carcinoma is shown. Important factors for optimal MR imaging of cervical carcinoma are reviewed. The value of MR imaging in the staging of cervical carcinoma is illustrated by showing parametrial invasion and lymph node involvement. Finally, the value of MR imaging staging is compared with clinical staging, CT staging, and surgical findings. The role of new imaging techniques, such as fast dynamic enhanced MR imaging, is described. (orig.)

2000-01-01

285

Expression of CHOP in squamous tumor of the uterine cervix.  

UK PubMed Central (United Kingdom)

BACKGROUND: High-risk human papillomavirus (HR-HPV) infection and abnormal p53 expression are closely involved in carcinogenesis of squamous cell carcinoma (SqCC) of uterine cervix. Recent studies have suggested that virus-induced endoplasmic reticulum (ER) stress modulates various cell survival and cell death signaling pathways. The C/EBP homologous protein (CHOP) is associated with ER stress-mediated apoptosis and is also involved in carcinogenesis of several human cancers. We hypothesized that CHOP is involved in the carcinogenesis of uterine cervical cancer in association with HR-HPV and/or p53. METHODS: Immunohistochemistry was used to analyze CHOP and p53 protein expression of tissue sections from 191 patients with invasive cancer or preinvasive lesions of the uterine cervix (61 cases of SqCC, 66 cases of cervical intraepithelial neoplasia [CIN] III, and 64 cases of CIN I). RESULTS: CHOP was expressed in 59.4% of CIN I, 48.5% of CIN III, and 70.5% of SqCC cases. It was also significantly more frequent in invasive SqCC than in preinvasive lesions (p=0.042). Moreover, CHOP expression significantly correlated with HR-HPV infection and p53 expression (p=0.009 and p=0.038, respectively). CONCLUSIONS: Our results suggest that CHOP is involved in the carcinogenesis of the uterine cervix SqCC via association with HR-HPV and p53.

Chu HH; Bae JS; Kim KM; Park HS; Cho DH; Jang KY; Moon WS; Kang MJ; Lee DG; Chung MJ

2012-10-01

286

Prevalência do exame preventivo de câncer do colo do útero em Rio Branco, Acre, Brasil, e fatores associados à não-realização do exame Prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and factors associated with non-participation in screening  

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Full Text Available O objetivo do estudo foi determinar a prevalência autorreferida do exame preventivo de câncer do colo uterino em Rio Branco, Acre, Brasil, e avaliar fatores associados com a não realização do exame. Trata-se de estudo transversal de base populacional, composto por 772 mulheres de 18 a 69 anos residentes em Rio Branco, no período 2007 a 2008. Os dados foram analisados no programa Stata 10.0 e estimadas razões de prevalências a partir da regressão multivariada de Poisson. O percentual de mulheres na população alvo que relatou pelo menos um exame nos últimos três anos foi de 85,3%, com acentuada utilização do Sistema Único de Saúde (72,8%). Foram encontradas razões de prevalência estatisticamente significativas quanto à ausência do exame em mulheres de 18 a 24 anos, de 60 a 69 anos, solteiras, com menor renda e baixa escolaridade. As magnitudes encontradas nas razões de prevalência foram consistentes com achados de outros estudos, apontando maior necessidade de intervenção no grupo de mulheres mais vulneráveis à incidência e mortalidade por câncer do colo do útero.The objective of the study was to determine the self-reported prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and to analyze factors associated with non-participation in screening. A population-based cross-sectional study with a sample of 772 women 18 to 69 years of age and living in Rio Branco was conducted in 2007 and 2008. Data were analyzed with Stata 10.0, and prevalence rates were estimated with Poisson multivariate regression (95%CI). 85.3% of women reported at least one cervical cancer screening test in the previous three years. The majority of women (72.8%) were screened in the Brazilian Unified National Health System. After adjusting for selected variables, statistically significant prevalence rates for absence of screening were found in women 18-24 and 60-69 years of age, single, and with low income and low schooling. The prevalence rates were consistent with findings from other studies, highlighting the need for greater intervention in the group of women most vulnerable to cervical cancer incidence and mortality.

Maria Fernanda de Sousa Oliveira Borges; Leila Maria Geromel Dotto; Rosalina Jorge Koifman; Margarida de Aquino Cunha; Pascoal Torres Muniz

2012-01-01

287

[Gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and interleukins 2, 4 and 6 (IL-2, IL-4, IL-6) in cervical-uterine cells of intraepithelial neoplasia: a preliminary report].  

Science.gov (United States)

The purpose of this work was to determine the expression of type Th1 cytokines: IL-2 and IFNgamma, and Th2: IL-4 and IL-6, as well as TNF-alpha in patients with precancerous lesions of the uterine cervix and their relationship with the human papiloma virus (HPV). 30 patients with precancerous lesions (NIC 1: 70%, NIC 2: 16.7% and NIC 3: 1.3%) and 9 normal controls were studied. A clinical history, gynecological evaluation, cytology and an uterine biopsy were carried out in each patient and control. PCR was used for the diagnosis of HPV. IFN-gamma expression (positive cells/field) was increased in patients with NIC (5.06 +/- 4.7 vs 0 in the control group; p < 0.05). TNFa was a little higher in pathologycal tissues than in the controls (5.23 +/- 3.63 vs 1.55 +/- 2.65; p < 0.05). IL-2 was higher in pathologycal cases than in the controls (8.73 +/- 5.23 vs 0.33 +/- 1, p < 0.05). IL-4 were expressed in both, patients and controls (6.53 +/- 5.23 vs 5.77 +/- 7.32). IL-6 was also higher in patients (4.63 +/- 3.34 vs 0.77 +/- 2.33; p < 0.05). When the HPV status was considered, only IFN-gamma (p < 0.05) and IL-2 (p < 0.05) were significantly higher in HPV positive patients (n = 4) compared to controls. When HPV+ patients were compared with HPV- patients, only IFNgamma was significant (11.5 +/- 5 vs 4.07 +/- 3.8; p < 0.05). In conclusion, Type Th1 immune response prevails in patients with precancerous lesions, whether they are HPV positive or not. PMID:15782532

Pardo-Govea, Tatiana; Callejas, Diana; Núñez-Troconis, José; Araujo, Mary; Costa, Luciana; Pons, Héctor; Delgado, Mariela; Monsalve, Francisca

2005-03-01

288

Adenocarcinoma metastatic to the uterine cervix: a case series.  

UK PubMed Central (United Kingdom)

AIMS: The objectives of this report are, first, to describe the clinical behavior of cases of carcinoma metastatic to the uterine cervix treated at our institution in order to carry out a systematic review to establish the behavioral patterns of the most frequent metastases to the cervix and, second, to generate guidelines for their diagnosis and treatment. METHODS: At the National Institute of Cancer of Mexico (INCan), we performed a review of the clinical files with a diagnosis of malignant neoplasm metastatic to the uterine cervix between 1990 and 2009. For a systematic review, we conducted a PubMed search between the years 1970 and 2009 of case reports and series of cases of patients with metastatic gastric, breast, ovarian and colorectal cancer. We analyzed each report individually and extracted the patients' clinical data from our cases and reports, including the primary tumor, cervical metastases and survival rates. RESULTS: There were 10 cases of tumors metastatic to the uterine cervix. Metastasis was documented in one-half of the patients during follow up, with two of these cases having the cervix as the only site. We included the following reports in the systematic review: 13 reports of gastric-associated cancer, 30 related to breast cancer, nine with ovarian-associated cancer and 10 related to colorectal cancer. CONCLUSIONS: Metastatic cervical activity is an infrequent event. The prognosis of survival is poor in the presence of gastric or ovarian cancer and cervical metastases.

Pérez-Montiel D; Serrano-Olvera A; Salazar LC; Cetina-Pérez L; Candelaria M; Coronel J; Montalvo LA; de León DC

2012-03-01

289

[Hematometra in patients with cervical cancer--its CT presentation and clinical significance  

UK PubMed Central (United Kingdom)

Cervical cancer is the most common gynecologic malignancy in Chinese. Clinical staging has been traditionally used in cervical cancer, according to international Federation of Gynecology and Obstetrics (FIGO) staging classification. Computed tomography was an adjunctive modality for detecting paraaortic lymph nodes in preoperative evaluation. But CT has failed to accurately define the extent of parametrial and vaginal invasion. Here, an attempt has been made to define indirect clues alerting to invasive cervical cancer. Hematometra can be seen in CT as a dilated uterine cavity with retention of significant fluid. The incidence of hematometra was 5% (5/101) in control group, and 26% (22/84) in cervical cancer. Hematometra cannot be more specific for cervical cancer, with an accuracy of 64%, sensitivity of 82% and specificity of 61%. Hematometra was found to have a statistically high relationship with high cancer staging and uterine invasion. The Chi-square values were 14.8 (P < 0.005) in high cancer staging, and 19.8 in uterine invasion. The accuracy of hematometra was 65% in high cancer staging, and 74% in uterine invasion. Hematometra was more common in postmenopause women, with accuracy elevated to 80% for uterine invasion. This is probably related to senile atrophy or endophytic growth of the cervix into the uterus as well as to hormone replacement. These were five false positive instances of hematometra, all unrelated to cervical cancer. They presented with marked fluid and a solid mass in the uterine cavity, and included endometrial adenocarcinoma, uterine myoma and leiomyosarcoma. None of cervical cancer showed a solid mass in a dilated uterine cavity.(ABSTRACT TRUNCATED AT 250 WORDS)

Hsu SM; Pan HB; Kan YY; Chang JM; Yang CF

1993-02-01

290

Therapeutic efficacy of uterine arterial embolization for intractable uterine hemorrhage  

International Nuclear Information System (INIS)

Objective: To evaluate the therapeutic efficacy of uterine arterial embolization (UAE) for intractable uterine hemorrhage. Methods: 16 patients with intractable uterine hemorrhage underwent bilateral UAE after failed conventional conservative treatment. Results: Uterine hemorrhage ceased within 12 hours in 15 patients (93.8%) after bilateral super-selective UAE. Internal iliac artery embolization was performed on one patient (6.2%) and hysterectomy was eventually carried out because of recurrent hemorrhage. Conclusion: UAE is a rapid and effective treatment method obviating hysterectomy for intractable uterine hemorrhage. (authors)

2010-01-01

291

Uterine arteriovenous malformation.  

UK PubMed Central (United Kingdom)

Uterine arteriovenous malformation (AVM) is a rare condition, with fewer than 100 cases reported in the literature. Despite it being rare, it is a potentially life-threatening condition. This case report describes a 33-year-old woman who presented with secondary post-partum hemorrhage. Transabdominal ultrasound (US) of the pelvis showed increased vascularity with multidirectional flow of the uterus and a prominent vessel, located on the left lateral wall. She also had retained product of conception, which complicated the diagnosis. A uterine artery angiogram confirmed an AVM in the fundal region with an early draining vein. Embolisation of the AVM was performed successfully.

Hashim H; Nawawi O

2013-03-01

292

Diagnosis and management of Mullerian adenosarcoma of the uterine cervix.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To report on the diagnosis and management of Müllerian adenosarcoma of the uterine cervix at a gynecologic oncology unit in Singapore. METHODS: Nine cases (1992-2008) were identified from the unit registry. All hospital records were retrospectively analyzed. RESULTS: Mean age at diagnosis was 45±12 years (range, 17-61 years). Presenting symptoms were abnormal vaginal bleeding (5 [55.6%] patients), introital mass (3 [33.3%] patients), and foul-smelling vaginal discharge (1 [11.1%] patient). Two (22.2%) patients were asymptomatic, with cervical polyps discovered incidentally on routine gynecologic check-up. All women had benign-looking cervical polyps and underwent polypectomy. Histology showed increased stromal cellularity with periglandular cuffs in all patients, and heterologous differentiation in 1(11.1%) patient. All 9 women had FIGO stage 1B disease. Seven (77.8%) patients underwent radical hysterectomy with bilateral adnexectomy and pelvic lymphadenectomy. One (11.1%) woman underwent cervical wedge resection and 1 (11.1%) refused definitive surgery. There was no recurrence in the 6 patients for whom complete follow-up data were available. CONCLUSION: Clinical diagnosis of Müllerian adenosarcoma of the uterine cervix may be challenging owing to the benign gross appearance of the cervical polyps. Surgery provides a good chance of cure with no recurrence.

Chin PS; Chia YN; Lim YK; Yam KL

2013-06-01

293

[Conservative management of cervical ectopic pregnancy].  

UK PubMed Central (United Kingdom)

BACKGROUND: Cervical ectopic pregnancy is a rare type of ectopic pregnancy (less than one percent of all ectopic pregnancies). OBJECTIVE: Assess the efficacy of the treatment options available. MATERIAL AND METHODS: Retrospective study of the cervical ectopic pregnancies treated in our hospital from January 2005 to December 2011. RESULTS: Three patients were diagnosed cervical ectopic pregnancy in our hospital during that period, that is, an incidence of 1.7 per 10,000 gestations. The main symptom was a moderate-to-severe genital hemorrhage. In two of the cases a single dose of 50 mg/cm2 methotrexate was administered, and in the third one, curettage and uterine arterial embolization were performed. Histerectomy was not necessary in either of the cases. CONCLUSION: Conservative management of cervical ectopic pregnancy is an effective and safe option.

Bretón P; Garcés M; Orós D; González de Agüero R; Romero MA; Fabre E

2012-08-01

294

Imaging of cervical carcinomas  

International Nuclear Information System (INIS)

[en] Recently, magnetic resonance imaging (MRI) and transrectal or transvaginal ultrasound (TRUS, TVUS) had an important place in imaging techniques of cervical carcinomas and raise the question of modifying the imaging strategies. For the diagnosis of primitive tumor, those techniques cannot take the place of clinical examination and gross examination. In the assessment of parametrial involvement, TRUS which has better accuracy than clinical examination, and MRI which is considered as the most accurate technique, have an important role to play. In the follow-up and the detection of recurrences, MRI is actually considered as the best imaging technique. The authors, according to recent data in literature and their own experience, present basic concepts of imaging strategies for staging and follow-up of cervical carcinomas[fr] Recemment la resonance magnetique et l'echographie endocavitaire ont conquis une place importante dans l'imagerie des cancers du col uterin. Si dans le cadre du diagnostic lesionnel, aucune de ces deux techniques ne peut remplacer l'examen clinique et l'anatomopathologie, par contre, dans le cadre du bilan d'extension, l'echographie, transrectale parait tres prometteuse dans l'evaluation de l'extension parametriale. De meme pour la plupart des auteurs anglo-saxons, la resonance magnetique est la meilleure methode d'appreciation de l'envahissement parametrial. Enfin, dans le cadre de la surveillance et de la recherche de recidive, la resonance magnetique est consideree comme la meilleure technique d'imagerie. Les auteurs, au vu des donnees recentes de la litterature et de leur propre experience, evaluent le role respectif de chaque technique d'imagerie et situent la place des nouvelles techniques au sein de la strategie diagnostique des cancers du col uterin

1990-01-01

295

Uterine artery embolization for symptomatic uterine fibroids.  

UK PubMed Central (United Kingdom)

BACKGROUND: Uterine fibroids cause heavy prolonged bleeding, pain, pressure symptoms and subfertility. The traditional method of treatment has been surgery as medical therapies have not proven effective. Uterine artery embolization (UAE) has been reported to be an effective and safe alternative to treat fibroids in women not desiring future fertility. There is a significant body of evidence based on case controlled studies and case reports. This is an update of the review previously published in 2006. OBJECTIVES: To review the benefits and risks of uterine artery embolization (UAE) versus other medical or surgical interventions for symptomatic uterine fibroids. SEARCH METHODS: We searched the Cochrane Menstrual Disorders & Subfertility Group Trials register (searched November 2011), the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, 4th Quarter 2011), MEDLINE (1950 to November 2011) and EMBASE (January 1980 to November 2011). We also contacted authors of eligible RCTs for unpublished data. SELECTION CRITERIA: Randomised controlled trials (RCTs) of UAE versus any medical or surgical therapy for symptomatic uterine fibroids. DATA COLLECTION AND ANALYSIS: Two of the authors (AS and JKG) assessed the trials and extracted the data independently. MAIN RESULTS: Five RCTs were included in this review. Three trials compared UAE with abdominal hysterectomy in 291 women. A fourth trial included 157 women and compared UAE with surgery (43 hysterectomies and 8 myomectomies). The fifth trial included 121 women and compared UAE with myomectomy in women wishing to preserve fertility.There was moderately good evidence that there is no significant difference between UAE and surgery in patient satisfaction rates at two years (OR 0.69, 0.40 to 1.21, 516 women, 5 trials) nor at five years (OR 0.90, 95% CI 0.45 to 1.80, 295 women, 2 trials). There was very low level evidence suggesting that myomectomy may be associated with better fertility outcomes than UAE, but this analysis was restricted to the limited cohort of women (n=66) who tried to conceive in the single study of UAE versus myomectomy (live birth: OR 0.33, 95% CI 0.11 to 1.00; pregnancy: OR 0.29, 95% CI 0.10 to 0.85). There was no significant difference between the two interventions in the rate of major complications. Compared to surgery, UAE significantly reduced the length of the procedure, length of hospital stay and time to resumption of routine activities and also decreased the likelihood of needing a blood transfusion. However, UAE was associated with higher rates of minor short term and long term complications, more unscheduled readmissions after discharge and an increased surgical reintervention rate. This increase in the surgical reintervention rate may balance out the initial cost advantage of UAE (reinterventions within 2 years: OR 5.64, 95% CI 2.92 to 10.90, 486 women, 4 trials; within 5 years: OR 5.79, 95% CI 2.65 to 12.65. 289 women, 2 trials). There was no significant difference in ovarian failure rates at long term follow-up. AUTHORS' CONCLUSIONS: UAE appears to have an overall patient satisfaction rate similar to hysterectomy and myomectomy and offers an advantage with regards to a shorter hospital stay and a quicker return to routine activities. However, UAE is associated with a higher rate of minor complications and an increased likelihood of requiring surgical intervention within two to five years of the initial procedure. There is very low level evidence suggesting that myomectomy may be associated with better fertility outcomes than UAE, but more research is needed.

Gupta JK; Sinha A; Lumsden MA; Hickey M

2012-01-01

296

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... 1,000 uterine fibroid embolizations. Fibroids are common, benign tumors in women. They can range in size from ... they're not causing a problem. These are benign tumors. They're non-cancerous tumors. So if you ...

297

Outcome of third trimester pregnancies after cryotherapy of the uterine cervix.  

UK PubMed Central (United Kingdom)

A retrospective study was undertaken to assess the effect of cryotherapy of the uterine cervix on the outcome of third trimester pregnancies. It was concluded that cryosurgery of the cervix had no effect on the onset or progress of labour, or on the infant, an important advantage compared with cold-knife conization as a therapy for young women with cervical intraepithelial neoplasia.

Hemmingsson E

1982-08-01

298

Acupuncture for uterine fibroids.  

UK PubMed Central (United Kingdom)

BACKGROUND: Uterine fibroids (UFs) are benign growths within the uterine muscle and are present in 30% of women during their reproductive years. With the exception of hysterectomy, there are no effective medical and surgical treatments for women with uterine fibroids . Acupuncture is an ancient Chinese method which has been used for both the prevention and treatment of diseases for over three thousand years. There are many types of acupuncture used to manage UFs, with body acupuncture being the most commonly used. The literature reporting the benefits or harms of acupuncture for the management of UFs has not yet been systematically reviewed. OBJECTIVES: To assess the benefits and harms of acupuncture in women with uterine fibroids SEARCH STRATEGY: The following electronic databases were searched 21st May 2009: the Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; AMED; the Menstrual Disorders and Subfertility Group's Specialised Register of Trials; Chinese Biomedical Literature Database (CBM); Traditional Chinese Medical Literature Analysis and Retrieval System (TCMLARS); Chinese Medical Current Contents (CMCC) and China National Knowledge Infrastructure(CNKI). Citation lists, experts in the field and grey literature were also referred to. No restrictions such as language were applied. SELECTION CRITERIA: All randomised controlled trials (RCTs) comparing acupuncture management with placebo acupuncture, no management, Chinese medication, Western medication or other managements of uterine fibroids were considered for inclusion. Acupuncture management included either traditional acupuncture or contemporary acupuncture, regardless of the source of stimulation (for example, body, electro, scalp, elongated, fire, hand, fine needle, moxibustion). Acupuncture management without needling was excluded. DATA COLLECTION AND ANALYSIS: Two review authors assessed trial risk of bias according to our a priori criteria. No trials were included in this version of the review, therefore no data was collected. MAIN RESULTS: No randomized double-blind controlled trials met the inclusion criteria . AUTHORS' CONCLUSIONS: The effectiveness of acupuncture for the management of uterine fibroids remains uncertain. More evidence is required to establish the efficacy and safety of acupuncture for uterine fibroids.There is a continued need for well designed RCTs with long term follow up.

Zhang Y; Peng W; Clarke J; Liu Z

2010-01-01

299

CRYOTHERAPY IN CERVICAL INTRAEPITHELIAL NEOPLASIA  

Directory of Open Access Journals (Sweden)

Full Text Available Cryotherapy is a time proven ablative method of treating lower grades of cervical dysplasia. It  is done using compressed CO2 or N2O refrigerant with the aim of creating an ice ball with a depth of freeze denoted by a peripheral margin of 4-5 mm of frost. It is performed using a double freeze or single freeze technique. Currently the double freeze technique of cryotherapy is an accepted treatment for mild and focal moderate dysplasia of the uterine cervix. The success of cryotherapy is determined by five factors : patient anatomy, pathology, equipment, technique and physician skill. Here we have a brief review of cryotherapy as an effective modality in treatment of lower grades of cervical intraepithelial neoplasias.

Naina Kumar

2013-01-01

300

Evidence for benefits from treating cervical ectopy: literature review/ Evidências de benefícios no tratamento de ectopia do colo do útero: revisão de literatura  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese CONTEXTO E OBJETIVO: A ectopia do colo do útero é hoje considerada um fenômeno fisiológico, mas parece ainda haver uma forte tendência no sentido da intervenção (tratamento). Este estudo se propõe a realizar revisão da literatura buscando evidências de benefícios conseqüentes ao tratamento da ectopia. MÉTODOS: Pesquisa nas bases Medical Literature Analysis and Retrieval Sysem Online (Medline), Excerpta Medica Database (Embase), Literatura Latino-Americane e d (more) o Caribe em Ciências da Saúde (Lilacs), Biblioteca Cochrane e seis livros especializados. RESULTADOS: A revisão mostrou que: 1) existe provavelmente associação de ectopia com infecção cervical por Chlamydia trachomatis, pelo vírus HPV e maior risco de soroconversão para HIV; 2) existe provavelmente associação entre ectopia e neoplasia intra-epitelial cervical; 3) existe associação com mucorréia e nictúria; 4) não existem evidências sobre associação entre ectopia e câncer de colo do útero nem sobre proteção contra este câncer proporcionada pelo tratamento da ectopia. CONCLUSÕES: 1) Não foram encontrados na literatura dados que justifiquem o tratamento rotineiro da ectopia; 2) O tratamento pode ser utilizado para tratar sintomas associados à ectopia, porém mais sintomas são atribuídos à ectopia do que se pôde confirmar em um estudo controlado; 3) Seriam necessários novos estudos para testar a hipótese de proteção contra o câncer de colo proporcionada pelo tratamento. Abstract in english CONTEXT AND PURPOSE: Uterine cervical ectopy (cervical erosion) is today considered to be a physiological condition, but there still seems to be a strong tendency towards treating it. The purpose of this study was to review the medical literature for evidence regarding benefits from treating cervical ectopy. METHODS: The following databases were reviewed: Medical Literature Analysis and Retrieval System Online (Medline), Excerpta Medica Database (Embase), Literatura Latin (more) o-Americana e do Caribe em Ciências da Saúde (Lilacs) and Cochrane Library databases. In addition, six medical textbooks were consulted. RESULTS: The review showed that: 1) there is probably an association between ectopy and higher risk of Chlamydia trachomatis, human papillomavirus and human immunodeficiency virus infection; 4) there is probably an association between ectopy and cervical intraepithelial neoplasia; 5) there is an association between ectopy and mucous discharge and nocturia; and 6) there is no evidence of an association between ectopy and cervical cancer, or of protection against cervical cancer associated with ectopy treatment. CONCLUSIONS: 1) No data were found in the medical literature to support routine treatment for ectopy; 2) Treatment could be recommended for symptom relief, but more symptoms are attributed to ectopy than could be demonstrated in a controlled study; 3) Further studies to test the hypothesis of protection against cervical cancer associated with treatment are necessary.

Machado Junior, Luís Carlos; Dalmaso, Ana Sílvia Whitaker; Carvalho, Heráclito Barbosa de

2008-03-01

 
 
 
 
301

Wind Erosion Research  

Science.gov (United States)

Wind Erosion Research (WER) provides science-based wind erosion technology for environmentally, economically, and socially sustainable agriculture in the United States. This website introduces the Wind Erosion Equation (WEQ), the first model for estimating soil loss by wind from agricultural fields and the newly developed Wind Erosion Prediction System (WEPS) which provides new capabilities assessing plant damage and calculating suspension loss. Simulation models, multimedia archive and history of wind erosion research are available for educators and students.

2006-02-27

302

Cervical cytology in serous and endometrioid endometrial cancer.  

UK PubMed Central (United Kingdom)

The aim of this study was to determine the frequency of abnormal cervical cytology in preoperative cervical cytology of patients diagnosed with uterine papillary serous carcinoma (UPSC) and endometrioid endometrial carcinoma (EEC). In addition, associations between abnormal cervical cytology and clinicopathologic factors were evaluated. In this multicentre study, EEC patients diagnosed at two hospitals from 1999 to 2009 and UPSC patients diagnosed at five hospitals from 1992 to 2009, were included. Revision of the histologic slides was performed systematically and independently by 3 gynecopathologists. Cervical cytology within six months before histopathologic diagnosis of endometrial carcinoma was available for 267 EEC and 80 UPSC patients. Cervical cytology with atypical, malignant, or normal endometrial cells in postmenopausal women was considered as abnormal cytology, specific for endometrial pathology. Abnormal cervical cytology was found in 87.5% of UPSC patients, compared with 37.8% in EEC patients. In UPSC, abnormal cytology was associated with extrauterine spread of disease (P=0.043). In EEC, abnormal cytology was associated with cervical involvement (P=0.034). In both EEC and UPSC patients, abnormal cervical cytology was not associated with survival. In conclusion, abnormal cervical cytology was more frequently found in UPSC patients. It was associated with extrauterine disease in UPSC patients, and with cervical involvement in EEC patients. More prospective research should be performed to assess the true clinical value of preoperative cervical cytology in endometrial cancer patients.

Roelofsen T; Geels YP; Pijnenborg JM; van Ham MA; Zomer SF; van Tilburg JM; Snijders MP; Siebers AG; Bulten J; Massuger LF

2013-07-01

303

Cervical cytology in serous and endometrioid endometrial cancer.  

Science.gov (United States)

The aim of this study was to determine the frequency of abnormal cervical cytology in preoperative cervical cytology of patients diagnosed with uterine papillary serous carcinoma (UPSC) and endometrioid endometrial carcinoma (EEC). In addition, associations between abnormal cervical cytology and clinicopathologic factors were evaluated. In this multicentre study, EEC patients diagnosed at two hospitals from 1999 to 2009 and UPSC patients diagnosed at five hospitals from 1992 to 2009, were included. Revision of the histologic slides was performed systematically and independently by 3 gynecopathologists. Cervical cytology within six months before histopathologic diagnosis of endometrial carcinoma was available for 267 EEC and 80 UPSC patients. Cervical cytology with atypical, malignant, or normal endometrial cells in postmenopausal women was considered as abnormal cytology, specific for endometrial pathology. Abnormal cervical cytology was found in 87.5% of UPSC patients, compared with 37.8% in EEC patients. In UPSC, abnormal cytology was associated with extrauterine spread of disease (P=0.043). In EEC, abnormal cytology was associated with cervical involvement (P=0.034). In both EEC and UPSC patients, abnormal cervical cytology was not associated with survival. In conclusion, abnormal cervical cytology was more frequently found in UPSC patients. It was associated with extrauterine disease in UPSC patients, and with cervical involvement in EEC patients. More prospective research should be performed to assess the true clinical value of preoperative cervical cytology in endometrial cancer patients. PMID:23722512

Roelofsen, Thijs; Geels, Yvette P; Pijnenborg, Johanna M A; van Ham, Maaike A P C; Zomer, Saskia F; van Tilburg, Johanna M Wiersma; Snijders, Marc P M L; Siebers, Albert G; Bulten, Johan; Massuger, Leon F A G

2013-07-01

304

Cervical cancer.  

UK PubMed Central (United Kingdom)

Squamous cell cervical cancer incidence and mortality have been reduced dramatically as a result of successful screening in many countries. The incidence of cervical adenocarcinoma continues to increase. There has been concentrated effort toward improving early detection and screening by utilizing molecular biomarker assays. The FIGO staging system for cervical cancer was revised in 2009. Fertility preservation can be offered to patients with early-stage cervical cancer through radical trachelectomy, although radical hysterectomy remains the surgical standard of care. Concurrent chemotherapy with radiation has been shown to have a survival advantage in patients with advanced-stage disease. Improvements in radiation techniques and molecular targeted therapy are the current research venues in cervical cancer.

Lea JS; Lin KY

2012-06-01

305

Cervical cancer.  

Science.gov (United States)

Squamous cell cervical cancer incidence and mortality have been reduced dramatically as a result of successful screening in many countries. The incidence of cervical adenocarcinoma continues to increase. There has been concentrated effort toward improving early detection and screening by utilizing molecular biomarker assays. The FIGO staging system for cervical cancer was revised in 2009. Fertility preservation can be offered to patients with early-stage cervical cancer through radical trachelectomy, although radical hysterectomy remains the surgical standard of care. Concurrent chemotherapy with radiation has been shown to have a survival advantage in patients with advanced-stage disease. Improvements in radiation techniques and molecular targeted therapy are the current research venues in cervical cancer. PMID:22640713

Lea, Jayanthi S; Lin, Ken Y

2012-04-24

306

Conservative management of cervical pregnancy: a report of two cases.  

UK PubMed Central (United Kingdom)

BACKGROUND: Cervical ectopic pregnancy is a rare form of ectopic pregnancy. Treatment of this clinical condition is controversial. Previously, hysterectomy was the mainstay of treatment, but in the recent past various conservative management approaches have been applied to preserve fertility. We report 2 such cases in which conservative approach was implemented. CASES: Case 1 was an early, nonviable cervical pregnancy in which systemic methotrexate was used with success. Case 2 was a viable, advanced cervical pregnancy (at 11 weeks) in which a combination of uterine artery embolization and systemic methotrexate was used. Ultimately this patient required hysterectomy due to sudden massive hemorrhage on day 22 of intervention. CONCLUSION: On reviewing our results and the literature, we conclude that uterine artery embolization with methotrexate is effective in reducing the ectopic cervical mass. However, there is always a risk of hemorrhage, which can be treated by either repeat uterine artery embolization alone or uterine artery embolization followed by curettage. Hysterectomy should be the last resort if all conservative methods fail.

Chaudhary V; Sachdeva P; Kumar D; Arora R; Banavaliker J; Khan M

2013-09-01

307

PREGNANCY OUTCOME FOLLOWING CERVICAL ENCERCLAGE OPERATION  

Directory of Open Access Journals (Sweden)

Full Text Available Background -Recurrent second trimester abortions and  premature deliveries, continue to be two of the main  problems of modern obstetrics and perinatal medicine . Cervical incompetency or insufficiency is defined as“the inability of the uterine cervix to retain a pregnancy in the absence of contractions or labor. Cervical encerclage is considered as a simple but useful minor surgical procedure for improving the fetal salvage in proven cases of cervical incompetence. Material and Methods-A prospective analytical study was carried out at tertiary care teaching hospital for a period of seven years. Sixty cases of bad obstetrical history (repeated abortions, preterm labour) with previous pregnancy losses probably due to cervical incompetence were included in the study .These cases were subjected to cervical encerclage operation at various gestational periods. Results- Out of total fifty cases, who underwent McDonald’s procedure, 2 women had abortion , 11 had preterm labour and 37 women reached to term. Out of the ten cases, who underwent Wurm’s procedure,1 women had abortion ,2 had preterm deliveries and 7 women reached to term. In the present study, the average interval from cerclage to delivery was 95 days. It was observed that the fetal salvage rate  was unsatisfactory in women having short cervix with  open internal os  before cervical encerclage operation. Infant salvage rate in this study was 51.07% before and 84% after encerclage operation. Conclusion-Cervical encerclage done in properly selected cases, results in improvement in fetal salvage up to eighty percent.

Vidyadhar B Bangal; Satyajit P Gavhane; Gayatri K Khanvelkar; Neha A Patil

2012-01-01

308

Fatores de risco para câncer de colo do útero segundo resultados de IVA, citologia e cervicografia/ Risk factors for uterine cervical cancer according to results of VIA, cytology and cervicography/ Factores de riesgo para cáncer de cuello uterino según resultados de IVA, citología y cervicografía  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Este estudo objetivou avaliar a associação entre fatores de risco para câncer de colo do útero e lesões cervicais por HPV comparando-se os resultados da inspeção visual com o ácido acético (IVA), a citologia e a cervicografia. Realizou-se pesquisa de prevalência com 157 mulheres de um centro de saúde de Fortaleza, no período de junho a setembro de 2006. Utilizou-se o SPSS para codificar os dados. Realizaram-se inferências por meio de testes estatísticos ( (more) 67;2= quiquadrado e RV= razão de verossimilhança). IVA, cervicografia e citologia obtiveram 43,3%, 10,19% e 3,2% de resultados alterados, respectivamente. As variáveis com importante associação às lesões cervicais na IVA foram: idade menor de 20 anos (p= 0,0001); um ou mais parceiros nos últimos três meses (p= 0,015); uso de contraceptivos (p= 0,0008); presença de corrimento vaginal (p= 0,0001); e processo inflamatório moderado ou acentuado (p= 0,0001). Na citologia: baixa escolaridade (p= 0,0001) e elevado pH (p= 0,001). Não se encontrou associação significante na cervicografia. Abstract in spanish Este estudio objetivó evaluar la asociación entre factores de riesgo para cáncer de cuello de útero y lesiones cervicales por HPV, según comparación entre los resultados de la inspección visual con ácido acético (IVA), citología y cervicografía. Se realizó investigación de prevalencia, con 157 mujeres en un centro de salud de Fortaleza-CE-Brasil, en el período de junio a setiembre de 2006. Se utilizó el SPSS para codificar los datos. Se realizaron inferenci (more) as a través de tests estadísticos (?2 = Qui-cuadrado y RV= razón de verosimilitud). La IVA, cervicografía y citología obtuvieron 43,3%, 10,19% y 3,2% de resultados alterados. Las variables con importante asociación a lesiones cervicales en la IVA fueron: edad menor a 20 años (p=0,0001), uno o más parejas en los últimos tres meses (p=0,015), uso de anti-conceptivos (p=0,0008), presencia de vaginitis (p=0,0001) y pH elevado (p=0,001). No se encontró asociación significativa en la cervicografía. Abstract in english This study aimed to evaluate the association between risk factors for uterine cervical neoplasms and cervical lesions by HPV by comparison of the visual inspection with acetic acid (VIA), cytology and cervicography results. A prevalence research was made with 157 women in a health center of Fortaleza in the period of June to September 2006. The SPSS program was used to codify the data. Inferences were made through statistical tests (?2= chi square and LR= likelihood (more) ratio). The VIA, cervicography and cytology obtained 43.3%, 10.19% and 3.2% of altered results. The variables with important association to cervical lesions in the VIA were: aged less than 20 years old (p= 0.0001); one or more partners in the last three months (p= 0.015); use of contraceptives (p = 0.0008); presence of vaginal discharge (p= 0.0001) and moderate or accentuated inflammatory process (p= 0.0001). In the cytology: low instructional level (p= 0.0001) and high pH (p= 0.001). It wasn't found any significant association in the cervicography.

Anjos, Saiwori de Jesus Silva Bezerra dos; Vasconcelos, Camila Teixeira Moreira; Franco, Eugênio Santana; Almeida, Paulo César de; Pinheiro, Ana Karina Bezerra

2010-12-01

309

Fatores de risco para câncer de colo do útero segundo resultados de IVA, citologia e cervicografia Factores de riesgo para cáncer de cuello uterino según resultados de IVA, citología y cervicografía Risk factors for uterine cervical cancer according to results of VIA, cytology and cervicography  

Directory of Open Access Journals (Sweden)

Full Text Available Este estudo objetivou avaliar a associação entre fatores de risco para câncer de colo do útero e lesões cervicais por HPV comparando-se os resultados da inspeção visual com o ácido acético (IVA), a citologia e a cervicografia. Realizou-se pesquisa de prevalência com 157 mulheres de um centro de saúde de Fortaleza, no período de junho a setembro de 2006. Utilizou-se o SPSS para codificar os dados. Realizaram-se inferências por meio de testes estatísticos (?2= quiquadrado e RV= razão de verossimilhança). IVA, cervicografia e citologia obtiveram 43,3%, 10,19% e 3,2% de resultados alterados, respectivamente. As variáveis com importante associação às lesões cervicais na IVA foram: idade menor de 20 anos (p= 0,0001); um ou mais parceiros nos últimos três meses (p= 0,015); uso de contraceptivos (p= 0,0008); presença de corrimento vaginal (p= 0,0001); e processo inflamatório moderado ou acentuado (p= 0,0001). Na citologia: baixa escolaridade (p= 0,0001) e elevado pH (p= 0,001). Não se encontrou associação significante na cervicografia.Este estudio objetivó evaluar la asociación entre factores de riesgo para cáncer de cuello de útero y lesiones cervicales por HPV, según comparación entre los resultados de la inspección visual con ácido acético (IVA), citología y cervicografía. Se realizó investigación de prevalencia, con 157 mujeres en un centro de salud de Fortaleza-CE-Brasil, en el período de junio a setiembre de 2006. Se utilizó el SPSS para codificar los datos. Se realizaron inferencias a través de tests estadísticos (?2 = Qui-cuadrado y RV= razón de verosimilitud). La IVA, cervicografía y citología obtuvieron 43,3%, 10,19% y 3,2% de resultados alterados. Las variables con importante asociación a lesiones cervicales en la IVA fueron: edad menor a 20 años (p=0,0001), uno o más parejas en los últimos tres meses (p=0,015), uso de anti-conceptivos (p=0,0008), presencia de vaginitis (p=0,0001) y pH elevado (p=0,001). No se encontró asociación significativa en la cervicografía.This study aimed to evaluate the association between risk factors for uterine cervical neoplasms and cervical lesions by HPV by comparison of the visual inspection with acetic acid (VIA), cytology and cervicography results. A prevalence research was made with 157 women in a health center of Fortaleza in the period of June to September 2006. The SPSS program was used to codify the data. Inferences were made through statistical tests (?2= chi square and LR= likelihood ratio). The VIA, cervicography and cytology obtained 43.3%, 10.19% and 3.2% of altered results. The variables with important association to cervical lesions in the VIA were: aged less than 20 years old (p= 0.0001); one or more partners in the last three months (p= 0.015); use of contraceptives (p = 0.0008); presence of vaginal discharge (p= 0.0001) and moderate or accentuated inflammatory process (p= 0.0001). In the cytology: low instructional level (p= 0.0001) and high pH (p= 0.001). It wasn't found any significant association in the cervicography.

Saiwori de Jesus Silva Bezerra dos Anjos; Camila Teixeira Moreira Vasconcelos; Eugênio Santana Franco; Paulo César de Almeida; Ana Karina Bezerra Pinheiro

2010-01-01

310

Uterine arteriovenous malformation.  

UK PubMed Central (United Kingdom)

Uterine arteriovenous malformation (AVM) is a little known condition of which, to date, very few cases have been described. It has a very diverse symptomatology, even though in most cases, it is diagnosed during a severe and acute haemorrhagic event. Its treatment can vary from expectant management to hysterectomy; however, current evidence suggests that the embolisation of uterine arteries is the most effective approach, especially if fertility is to be preserved. We present a case report classified as AVM, with additional images that show the appearance of this pathology in a short span of time. This case has a number of peculiarities: unusual persistence of human chorionic gonadotropin hormone (?-HCG), asymptomatic patient, quick establishment of the lesion and its duration with unchanging characteristics and finally its spontaneous resolution without further consequences. This entity shows an aetiopathogenesis, that is, not well established or described. We discuss its physiopathology and aetiopathogenesis.

Sellers F; Palacios-Marqués A; Moliner B; Bernabeu R

2013-01-01

311

Management of Uterine Sarcomas  

Directory of Open Access Journals (Sweden)

Full Text Available Uterine sarcomas are rare malignant tumors characterized by a great clinical and histopathological diversity. The aim of this work is to analyze the difficulties of diagnosis, therapeutic and prognosis posed by these tumors. Thirty-seven patients with uterine sarcoma, collected in the service Radiotherapy and Oncology, University Ibn Rochd of Casablanca between January 2000 and December 2007 were included in this study retrospective. The average patient age was 50 years (17-76). The bleeding was present in all patients, isolated in 54% of cases associated with pelvic pain in 24.6% and a mass abdomino-pelvic in seven patients. The average time of evolution was 10 months. The main histological type was found leiomyosarcoma. Twenty four patients in our series underwent total hysterectomy without annexial conservation. The surgery R0 was obtained in 43% of cases. The sarcomas were classified as stage IV in 51.4%. Adjuvant radiotherapy was indicated in 13 patients. After a mean of 20 months, half of patients evaluable presented a local relapse and/or metastatic, the third of cases were tumor progression while complete remission was maintained in 18.5% of cases. Uterine sarcomas are rare malignant mesenchymal tumor, which often occur in women after menopause. The main prognostic factors are hormonal status of the patient, stage clinical, histological type, histological grade and quality surgical excision. The management of uterine sarcomas is multidisciplinary, based mainly on surgery remains the only means of cure. Adjuvant radiotherapy allows decreased risk of local recurrence, with no impact on survival achieved at best 30% at 5 years. The role of chemotherapy remains confirm.

Asmaa Naim; Zineb Bouchbika; Mohamed Aksim; Nadia Benchakroune; Hassan Jouhadi; Nezha Tawfiq; Souha Sahraoui; Soumia Zamiati; Abdelatif Benider

2012-01-01

312

Uterine artery embolisation.  

UK PubMed Central (United Kingdom)

PURPOSE OF STUDY: Fibroids are commonest benign tumour of the uterus. It presents with bleeding per vagina in most of the cases. Surgical treatment consists of myomectomy or hysterectomy with or without salpingo oophrectomy, with its inherent morbidity, prolonged hospital stay and psychosocial problems. Surgery is not the best option especially in unmarried and nullipara. MATERIALS AND METHODS: Thirty-five patients were subjected to uterine artery embolisation (UAE). Mean age was 35.51 ± 7.36 years. Two patients were suffering from advanced carcinoma of cervix, 32 had fibroid of uterus, one had endometriosis. Three patients were unmarried, three did not have any issue, three had associated haemodynamically significant cardiac disorders, one had polycystic renal disease, and one had hypernephroma. Four patients had multiple fibroids. The UAE was done through contralateral femoral artery puncture, bilaterally, with the help of Judkin's right coronary catheter. Ultrasound was repeated after 3 months. RESULTS: The UAE was successful in all patients. Mean procedural time was 75 minutes. Hospital stay was 1 day only. Bleeding stopped in all 35 patients. One patient had recurrence of bleeding after 2 months and underwent surgery. Fibroids disappeared in eight patients, decreased in size by > 75% in 11 patients, and by 50-75% in six patients. Five patients did not report back with ultrasound. Two patients had normal delivery after UAE. CONCLUSION: Uterine artery embolisation is effective therapy to stop uterine bleeding. It is effective in controlling the symptoms in uterine fibroids and also decreases the size of fibroids. Hospital stay is only 1 day.

Bhardwaj R

2012-05-01

313

Fan erosion control  

Energy Technology Data Exchange (ETDEWEB)

This paper deals with ways of controlling fly-ash erosion in coal-fired power plant fans. Computer calculations of particle trajectories through fans and of the resulting erosion rates are made for fans of varying designs to establish their relative erosion tolerance. An experimental study of the erosivity of fly-ash from burning bituminous and subbituminous coals and lignites is presented. The factors in obtaining highly erosion-resistant coatings, and the erosion resistance of advanced fly-ash armoring systems are examined. (orig.).

Menguetuerk, M.; Sverdrup, E.F.

1986-01-01

314

[Transcervical myomectomy and uterine fibroids: report of ten cases].  

UK PubMed Central (United Kingdom)

BACKGROUND: Uterine fibroids are the most common tumors of the uterus, their distribution in anatomical layers and segments of it are very varied clinical manifestations are usually abnormal bleeding and known treatments, the surgery is the most accomplished, either myomectomy or hysterectomy by both endoscopy and laparotomy, transvaginal approach is less common, but consider it a right way and solving the problem in selected cases. OBJECTIVE: To present a well-defined study protocol in patients with abnormal uterine bleeding, and myomectomy as a surgical transcervical simple, safe and effective in patients with intracavitary myoma protruded through the cervical canal. MATERIAL AND METHODS: ten patients are presented with abnormal uterine bleeding and anemia of various degrees, studied over a period of two years, following a research protocol for clinical methods, cabinet and laboratory diagnosis was submucosal fibroids with single fibroid, pedunculated protruding a vagina, treatment was performed transcervical myomectomy. RESULTS: The surgical procedure was obtained by solving the problem, having found the ten patients in the subsequent revisions in the outpatient, asymptomatic and without tumor lesions in the uterus. CONCLUSIONS: This study shows that performing a notarization in patients with abnormal uterine bleeding and making appropriate surgical treatment, achieves the desired objectives.

Cano López H; Cano Aguilar HE; Cano Aguilar FD

2012-10-01

315

Hysteroscopic metroplasty of the complete uterine septum, duplicate cervix, and vaginal septum.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To determine if sectioning of the cervical septum in hysteroscopic metroplasty of the complete uterine septum is associated with intraoperative bleeding, cervical incompetence, and secondary infertility. DESIGN: Multicenter, randomized, controlled clinical trial. SETTING: University hospitals. PATIENT(S): Twenty-eight women with a diagnosis of complete uterine septum who had a history of pregnancy wastage or infertility. They were randomized into two groups: group A underwent metroplasty including section of the cervical septum; group B underwent the same procedure with preservation of the cervical septum. INTERVENTION(S): Hysteroscopic metroplasty was performed for all patients in the two groups. MAIN OUTCOME MEASURE(S): Operating time, distending media deficit, total distending media used, intraoperative bleeding, complications, and reproductive outcome. RESULT(S): Operating times were 36.40 +/- 10.67 minutes and 73 +/- 14.40 minutes in group A and group B, respectively. Distending media deficit was 456.66 +/- 165.68 mL in group A, while in group B it was 673.84 +/- 220.36. Two cases of pulmonary edema and three cases of significant bleeding (> 150 mL) were seen in group B. The cesarean section rate was significantly higher in group B. There were no significant differences in the reproductive outcome in the two groups. CONCLUSION(S): Resection of the cervical septum during hysteroscopic metroplasty of complete uterine septum makes the procedure safer, easier, and less complicated than the procedure with preservation of the cervical septum. This procedure is recommended for all cases of complete uterine septum.

Parsanezhad ME; Alborzi S; Zarei A; Dehbashi S; Shirazi LG; Rajaeefard A; Schmidt EH

2006-05-01

316

Uterine Artery Embolization as Nonsurgical Treatment of Uterine Myomas  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The purpose of this study was to evaluate safety, efficacy or complications of uterine artery embolization (UAE). Patients with symptomatic uterine fibroids (n = 157) were treated by selective bilateral UAE using 350–500??m sized polyvinyl alcohol particles. Bilateral UAE was successful in 152 (96.8...

Tomislav, Strinic; Josip, Maskovic; Liana, Cambi Sapunar; Marko, Vulic; Marko, Jukic; Ante, Radic; Dzenis, Jelcic

317

Erosion Condition Classification System.  

Science.gov (United States)

This technical note has been designed to (1) present a revised system for classifying the degree of accelerated erosion condition and (2) to give guidance on the field method for measuring the erosion condition class for a sample area.

R. D. Clark

1980-01-01

318

Erosion-corrosion.  

Science.gov (United States)

A literature study on erosion-corrosion of pipings in the nuclear industry was performed. Occurred incidents are reviewed, and the mechanism driving the erosion-corrosion is described. Factors that influence the effect in negative or positive direction ar...

B. Aghili

1999-01-01

319

Uterine artery embolization for the treatment of uterine fibroids.  

UK PubMed Central (United Kingdom)

Uterine artery embolization can be regarded as a less invasive procedure for the treatment of fibroids compared with myomectomy, hysterectomy, and laparoscopic myolysis. The aim of this study was the evaluation of safety and efficacy of uterine artery embolization and of womens' opinion about this treatment. After gynecological examination sixty-nine premenopausal women underwent uterine artery embolization. All procedures but four were technically successful; three women underwent unilateral embolization because of vascular malformation and one of them had an allergic reaction to contrast medium. Of the 69 patients: 58 went home the day after embolization, and 11 within first week. The follow-up examinations after 3, 6 and 12 month showed a significant reduction of uterine and fibroid volume with significant improvement of bleeding. Therefore, according to this report, uterine artery embolization is a successful, minimal invasive treatment of myoma that preserves the uterus and requires shorter hospitalization and recovery times than surgery.

Strini? T; Vuli? M; Bukovi? D; Maskovi? J; Hauptman D; Jelinci? Z

2004-12-01

320

Low-cost technology for screening uterine cervical cancer/ Technique peu coûteuse de dépistage du cancer du col utérin/ Tecnología de bajo costo para el cribado del cáncer cervicouterino  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish El cáncer cervicouterino es el tumor maligno más frecuente entre las mujeres de la India. En los países en desarrollo no es posible emprender programas de cribado citológico de ámbito nacional debido a la escasez de personal adiestrado y a la falta de la infraestructura necesaria. La simple inspección visual del cuello uterino detecta los cánceres tempranos con una menor sensibilidad y especificidad que los estudios citológicos. En nuestros estudios anteriores hal (more) lamos una tasa de detección relativamente baja de las lesiones cervicouterinas precancerosas. A raíz de ello desarrollamos el Magnivisualizador, un dispositivo de iluminación y aumento cuyo precio es de Rs 1500 (US$ 36). Pretendíamos así mejorar la sensibilidad de la inspección visual simple en la detección de lesiones precancerosas o indicativas de cáncer temprano.De fácil manejo, este instrumento portátil funciona con una pila recargable de 12 V. Consiste en una cámara de luz con un reflector en un lado y un condensador en el otro, equipada con una bombilla halógena de 12 V y 50 W. La cámara tiene en la parte superior, en el extremo del condensador, un cristal de aumento de 2,5 dioptrías y 100 mm de diámetro. Los resultados de la inspección visual simple realizada mediante el Magnivisualizador fueron comparados con los de la colposcopia y/o los informes histológicos en una muestra de 402 mujeres. En total se diagnosticaron histológicamente 73 displasias leves, 76 displasias avanzadas y 59 carcinomas in situ o cánceres invasivos en sus primeras fases. En el caso de las displasias leves, la sensibilidad del análisis citológico fue del 75,3%, y la del Magnivisualizador, del 57,5%. En lo que atañe a las displasias graves y los carcinomas in situ o los cánceres invasivos tempranos, en cambio, la sensibilidad fue del 94,9% con los dos métodos. La tasa de falsos positivos fue del 1,0% en los estudios citológicos, frente al 5,7% con el Magnivisualizador. La especificidad del cribado alcanzó el 94,3% con este último, y el 99% en el análisis citológico.El Magnivisualizador aumentó considerablemente la sensibilidad conseguida mediante la inspección visual simple, no sólo en la detección de carcinomas in situ o de cánceres invasivos tempranos, sino también en el caso de las lesiones precancerosas. Su sensibilidad en la detección de las displasias avanzadas y las lesiones más graves precitadas fue comparable a la del análisis citológico, y disminuyó la tasa de falsos positivos. Además, el costo del examen con Magnivisualizador fue de US$ 0,55, mientras que el del análisis citológico fue de US$ 1,10. La sencilla inspección visual que permite el dispositivo puede realizarse incluso en un centro de atención primaria, sin más requisito que una mesa de exploración Abstract in english We report on an illuminated, low-cost (Rs 1500 (US$ 36)) magnifying device (Magnivisualizer) for detecting precancerous lesions of the uterine cervix. A total of 403 women attending a maternal and child health care clinic who had abnormal vaginal discharge and related symptoms were referred for detailed pelvic examination and visual inspection by means of the device after the application of 5% (v/v) acetic acid. Pap smears were obtained at the same time. The results were (more) compared with those obtained using colposcopy and/or histology. The Magnivisualizer improved the detection rate of early cancerous lesions from 60%, for unaided visual inspection, to 95%. It also permitted detection of 58% of cases of low-grade dysplasia and 83% of cases of high-grade dysplasia; none of these cases were detectable by unaided visual inspection. For low-grade dysplasia the sensitivity of detection by means of the Magnivisualizer was 57.5%, in contrast with 75.3% for cytological examination. However, the two methodologies had similar sensitivities for higher grades of lesions. The specificity of screening with the Magnivisualizer was 94.3%, while that of cytology was 99%. The cost per screening was approximate

Parashari, Aditya; Singh, Veena; Sehgal, Ashok; Satyanarayana, Labani; Sodhani, Pushpa; Gupta, Madan M.

2000-08-01

 
 
 
 
321

Can we rely on cancer mortality data? Checking the validity of cervical cancer mortality data for Slovenia  

International Nuclear Information System (INIS)

Background. Valid inference on cervical cancer mortality is very difficult since - on the basis of death certificates - it is not always possible to distinguish between cervix, corpus and unspecified uterine cancer deaths. Our aim was to estimate the extent to which cervical cancer as the official cause of death reflects the true mortality from cervical cancer in Slovenia. Material and methods. The data on 2245 deaths from cervix, corpus uteri, and uterus-unspecified cancers for the period 1985-1999 were linked to the Cancer Registry of Slovenia database from the mortality database of Slovenia. Results. Officially, in the period 1985-1999, there were 878 cervical cancer deaths. The comparison of these causes of death with the cancer sites registered in the Cancer Registry revealed that they include only 87.7% patients with a previous diagnosis of cervical cancer. Of 650 corpus uteri cancer deaths, 17. 1 % of patients were registered to have cervical cancer, and of 717 unspecified uterine cancer deaths, 31.4% were registered. Taking into account the correctly identified cervical cancer cases among cervical cancer deaths and misclassified cervical cancer deaths as corpus uteri and unspecified uterine, the corrected number of deaths would be 1106. Conclusions. When evaluating the impact of cervical cancer mortality from national mortality rates, the stated underestimation should be taken into account. However, this does not hold for some other cancers. (author)

2001-01-01

322

Radiculopatía cervical  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish La patología cervical traumática y su relación con el quehacer de la medicina legal tiene gran importancia y vigencia, principalmente cuando se hace necesario realizar valoraciones a pacientes con alteraciones cervicales y se debe definir si estas están en relación a un trauma determinado o repetitivo en el tiempo como puede ocurrir en algunos casos de riesgos de trabajo. El médico forense debe estar muy bien preparado, conocer la anatomía cervical y de los miembro (more) s superiores, realizar un interrogatorio y un examen físico neurológico exhaustivo para orientar las posibilidades diagnósticas; es fundamental además el análisis de los estudios diagnósticos. En este caso en particular se realizará una revisión de la radiculopatía cervical, su fisiopatología, mecanismos de producción y las implicaciones médico legales al realizar la valoración en pacientes con cervicobraquialgia Abstract in english Traumatic cervical pathology and its relationship to the work of forensic medicine is of great importance and relevance, especially when it is necessary to make assessments in patients with cervical changes and must be defined if they are in relation to a specific trauma or repetitive in time as may occur in some cases of occupational hazards. The medical examiner must be very well prepared, know the anatomy of the cervical and upper limbs, perform an examination and a th (more) orough neurological physical examination to guide the diagnostic possibilities, it is also fundamental analysis of diagnostic studies. In this particular case there will be a review of cervical radiculopathy, pathophysiology, mechanisms of production and the medico-legal implications when doing the assessment in patients with cervical braquial pain

Murillo Calderón, Adriana

2012-09-01

323

Erosion-corrosion  

International Nuclear Information System (INIS)

A literature study on erosion-corrosion of pipings in the nuclear industry was performed. Occurred incidents are reviewed, and the mechanism driving the erosion-corrosion is described. Factors that influence the effect in negative or positive direction are treated, as well as programs for control and inspection. Finally, examples of failures from databases on erosion-corrosion are given in an attachment

1999-01-01

324

Lajjalu treatment of uterine prolapse  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Mimosa pudica was found useful in cases of uterine prolapse with bleeding, consistent with my experience of working with the condition for more than 45 years, and treating hundreds of such cases of uterine prolapse. Hysterectomy has been avoided up to this date, and is not now expected to be recomme...

Shivanandaiah, T. M.; Indudhar, T. M.

325

Lajjalu treatment of uterine prolapse.  

UK PubMed Central (United Kingdom)

Mimosa pudica was found useful in cases of uterine prolapse with bleeding, consistent with my experience of working with the condition for more than 45 years, and treating hundreds of such cases of uterine prolapse. Hysterectomy has been avoided up to this date, and is not now expected to be recommended.

Shivanandaiah TM; Indudhar TM

2010-04-01

326

Lajjalu treatment of uterine prolapse.  

Science.gov (United States)

Mimosa pudica was found useful in cases of uterine prolapse with bleeding, consistent with my experience of working with the condition for more than 45 years, and treating hundreds of such cases of uterine prolapse. Hysterectomy has been avoided up to this date, and is not now expected to be recommended. PMID:21836800

Shivanandaiah, T M; Indudhar, T M

2010-04-01

327

Cervical cancer in India--strategy for control.  

Directory of Open Access Journals (Sweden)

Full Text Available The available information on the incidence of cancers by site in India have indicated that of incidence of cancer of uterine cervix among women is by far the highest compared to other sites in women. The epidemiology of cervical cancer has been studied extensively in India and in other countries. The majority of factors related to cervical cancer are associated with sexual behaviour. The available evidence for control of cervical cancer is through secondary prevention, namely--early detection through Pap smear. In the present communication the alternative strategies with secondary prevention for control of cervical cancer is worked out. Taking into consideration the number of cervical cancer cases saved, number of woman years saved and the cost aspects the strategy at present for India should be to provide one life time screening for women at the age of 45 years.

Prabhakar A

1992-01-01

328

Uterine Inversion; A case report.  

UK PubMed Central (United Kingdom)

The puerperal uterine inversion is a rare and severe complication occurring in the third stage of labour. The mechanisms are not completely known. However, extrinsic factors such as oxytocic arrests after a prolonged labour, umbilical cord traction or abdominal expression are pointed. Other intrinsic factors such as primiparity, uterine hypotonia, various placental localizations, fundic myoma or short umbilical cord were also reported. The diagnosis of the uterine inversion is mainly supported by clinical symptoms. It is based on three elements: haemorrhage, shock and a strong pelvic pain. The immediate treatment of the uterine inversion is required. It is based on a medical reanimation associated with firstly a manual reduction then surgical treatment using various techniques. We report an observation of a 25 years old grand multiparous patient with a subacute uterine inversion after delivery at home.

Bouchikhi C; Saadi H; Fakhir B; Chaara H; Bouguern H; Banani A; Melhouf M

2008-01-01

329

Potentialities in integral care: uterine cervical cancer prevention according to the users of the family health strategy Potencialidades en la atención integral: prevención de cáncer de cuello uterino de acuerdo con las usuarias de la estrategia salud de la familia Potencialidades no atendimento integral: a prevenção do câncer do colo do útero na concepção de usuárias da estratégia saúde da família  

Directory of Open Access Journals (Sweden)

Full Text Available This study aimed to analyze the integral care in the uterine cervical cancer prevention practices in the conception of users of the Family Health Strategy through an exploratory and descriptive research with a qualitative approach. A total of 14 users who performed the Pap smear in December 2002 in four Family Health Units affiliated to Higher Education institutions were selected for the study. Data were collected between April and June 2003. We found that the users analyze and assess the praxis by issuing a value judgment about the care they receive, mainly in terms of light (relational) technologies. Concluding, humanized practices provided by professional/team favor integral care, strengthening the bond between users and health services, as well as health promotion.El objetivo de este estudio fue analizar la atención integral dentro de las prácticas de prevención de cáncer de cuello uterino bajo la concepción de las usuarias de la Estrategia Salud de la Familia. Investigación de tipo exploratorio y descriptivo con enfoque cualitativo. Fueron seleccionadas catorce usuarias quienes realizaron el examen de Papanicolao durante el mes de diciembre de 2002, en cuatro Servicios de Salud de la Familia vinculados a Instituciones de Enseñanza Superior. La recolección de datos fue realizados entre abril y junio de 2003. Los resultados demuestran que las usuarias analizan y evalúan la atención recibida formando su opinión, en especial, con relación a las tecnologías leves (de relación). Se concluye que las prácticas humanizadas con responsabilidad profesional/equipo favorecen al cuidado integral, fortaleciendo el vínculo entre las usuarias con los servicios y la promoción de la salud.O objetivo deste estudo foi analisar o atendimento integral nas práticas de prevenção do câncer do colo do útero na concepção de usuárias da Estratégia Saúde da Família. Foi realizada pesquisa exploratória e descritiva com abordagem qualitativa dos dados. Foram selecionadas quatorze usuárias que realizaram o exame Papanicolaou no mês de dezembro de 2002 em quatro Unidades de Saúde da Família, vinculadas a instituições de nível superior. Os dados foram coletados no período de abril a junho de 2003. Como resultado foi observado que as usuárias analisam e avaliam a práxis emitindo juízo de valor à assistência recebida, principalmente, no que se refere às tecnologias leves (relacionais). Conclui-se que práticas humanizadas com responsabilização profissional/equipe favorecem cuidado integral fortalecendo o vínculo das usuárias com os serviços de saúde e a promoção da saúde.

Michele Mandagará de Oliveira; Ione Carvalho Pinto; Valéria Cristina Christello Coimbra

2007-01-01

330

Caracterização da demanda de pacientes com carcinoma de colo uterino no Hospital das Clínicas da Universidade Federal de Uberlândia, Minas Gerais, Brasil, 1984-1988 Characterization of uterine cervical carcinoma cases in the Hospital das Clínicas, Universidade Federal de Uberlândia, Minas Gerais, Brazil, from 1984 to 1988  

Directory of Open Access Journals (Sweden)

Full Text Available Foi realizado um estudo retrospectivo de 180 casos de carcinoma de colo uterino internados no Hospital das Clínicas da Universidade Federal de Uberlândia, no período de 1984 a 1988, segundo variáveis pessoais e de tempo. Encontrou-se um aumento gradativo com o tempo e uma maior freqüência entre 35 e 60 anos de idade. Aproximadamente 51% das pacientes eram provenientes de outras cidades e estados. Verificou-se uma maior freqüência em multíparas e em mulheres que iniciaram sua vida sexual antes dos 20 anos. Grande parte das mulheres (45%) ainda não tinha tido a menopausa. As manifestações clínicas mais freqüentes foram sangramento genital irregular e dor em baixo ventre. A citopatologia evidenciou Papanicolaou de graus III em 60,5% dos casos. A proporção de carcinoma in situ (20,6%) foi pequena em relação aos estágios mais avançados IIb (31,6%), Ib (14,5%), e IIIa, IIIb e IV (18,9%), os quais, havendo uma orientação mais sistematizada de prevenção, podem ser encontrados com menor freqüência. A relação carcinoma invasor/carcinoma in situ foi de 2,52 no período de 1984 a 1986, aumentando para 4,75 entre 1987 e 1988, o que indica não terem sido atingidos níveis satisfatórios de prevenção da doença na cidade e na região no período estudado.This is a retrospective survey of 180 cases of uterine cervical carcinoma in women admitted to the Hospital de Clínicas da Universidade Federal de Uberlândia, from 1984 to 1988, with regard to personal and temporal factors. There was a gradual increase in frequency over time and a greater frequency among women from 35 to 60 years of age. Half of the women came from other cities and states. The conditions was more frequent in multiparous women and in women who initiated sexual intercourse before the age of 20. A major proportion of women (45.0 %) had not reached menopause. Genital bleeding and abdominal pain were the most frequent clinical manifestations. Cytopathological study revealed a percentage of 60.5 % of stages III and IV. There was a low frequency of in situ cancer (20.6 %), when compared to the frequency of more advanced stages (71.6 %). The proportion of advanced stages as compared to in situ cancer increased over time, which may indicate that an optimal level of prevention was far reality in this region during the study period.

Eliane Regina Pioli; Neide M. de Oliveira; Alonso G. de Rezende

1993-01-01

331

A mulher japonesa vivenciando o câncer cérvico-uterino: um estudo de caso com abordagem da fenomenologia social La mujer japonesa vivenciando el cáncer cervico-uterino: un estudio del caso con abordaje fenomenológía social A japanese woman going through cervical uterine cancer: a case study with the social phenomenology approach  

Directory of Open Access Journals (Sweden)

Full Text Available Trata-se de estudo sobre a experiência de uma mulher japonesa, com câncer cérvico-uterino, realizado em um hospital da cidade de Osaka-Japão, no qual se utilizou o "estudo de caso" com abordagem da Fenomenologia Social de Alfred Schütz. Objetivou-se conhecer o significado da doença e da hospitalização para essa mulher, buscando compreender os motivos que envolvem a sua ação. Por meio da análise dos dados, foi possível compreender que o processo da hospitalização deve ser visto respeitando, além da característica individual, o mundo cultural que nos remete às ações humanas e que exerce influência importante no comportamento e atitude em relação à doença e hospitalização.Se trata de un estudio sobre la experiencia de una mujer japonesa, con cáncer cérvico-uterino, realizado en un hospital de la ciudad de Osaka-Japón, en el cual se utilizó el "estudio de caso" con abordaje de la Fenomenología Social de Alfred Schütz. El objetivo fue conocer el significado de la enfermedad y de la hospitalización para esa mujer, buscando comprender los motivos que involucran su acción. Por medio del análisis de los datos, fue posible comprender que el proceso de la hospitalización debe ser visto respetan-do, además de la característica individual, el mundo cultural que nos remite a las acciones humanas y que ejerce influencia importante en el comportamiento y actitud en relación a la enfermedad y hospitalización.This is the study of the experience of a Japanese woman with cervical uterine cancer carried out in a hospital in the city of Osaka, Japan, using Alfred Schütz's "case study" with the Social Phenomenology approach. The aim was to grasp the meaning of the disease and of hospitalization for this woman, and to try to understand the reasoning around her action. Through the analysis of the data, it was possible to understand that the hospitalization process has to be seen respecting, in addition to individual characteristics, the cultural world, which remits us to human actions and is an important influence on the behavior and attitude regarding the disease and hospitalization.

Rosa Yuka Sato Chubaci; Miriam Aparecida Barbosa Merighi; Yumi Yasumori

2005-01-01

332

A mulher japonesa vivenciando o câncer cérvico-uterino: um estudo de caso com abordagem da fenomenologia social/ A japanese woman going through cervical uterine cancer: a case study with the social phenomenology approach/ La mujer japonesa vivenciando el cáncer cervico-uterino: un estudio del caso con abordaje fenomenológía social  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Trata-se de estudo sobre a experiência de uma mulher japonesa, com câncer cérvico-uterino, realizado em um hospital da cidade de Osaka-Japão, no qual se utilizou o "estudo de caso" com abordagem da Fenomenologia Social de Alfred Schütz. Objetivou-se conhecer o significado da doença e da hospitalização para essa mulher, buscando compreender os motivos que envolvem a sua ação. Por meio da análise dos dados, foi possível compreender que o processo da hospitaliza? (more) ?ão deve ser visto respeitando, além da característica individual, o mundo cultural que nos remete às ações humanas e que exerce influência importante no comportamento e atitude em relação à doença e hospitalização. Abstract in spanish Se trata de un estudio sobre la experiencia de una mujer japonesa, con cáncer cérvico-uterino, realizado en un hospital de la ciudad de Osaka-Japón, en el cual se utilizó el "estudio de caso" con abordaje de la Fenomenología Social de Alfred Schütz. El objetivo fue conocer el significado de la enfermedad y de la hospitalización para esa mujer, buscando comprender los motivos que involucran su acción. Por medio del análisis de los datos, fue posible comprender que (more) el proceso de la hospitalización debe ser visto respetan-do, además de la característica individual, el mundo cultural que nos remite a las acciones humanas y que ejerce influencia importante en el comportamiento y actitud en relación a la enfermedad y hospitalización. Abstract in english This is the study of the experience of a Japanese woman with cervical uterine cancer carried out in a hospital in the city of Osaka, Japan, using Alfred Schütz's "case study" with the Social Phenomenology approach. The aim was to grasp the meaning of the disease and of hospitalization for this woman, and to try to understand the reasoning around her action. Through the analysis of the data, it was possible to understand that the hospitalization process has to be seen res (more) pecting, in addition to individual characteristics, the cultural world, which remits us to human actions and is an important influence on the behavior and attitude regarding the disease and hospitalization.

Chubaci, Rosa Yuka Sato; Merighi, Miriam Aparecida Barbosa; Yasumori, Yumi

2005-06-01

333

Integralidade na assistência à mulher na prevenção do câncer cérvico-uterino: um estudo de caso/ Integrality in women's health in the prevention of cervical-uterine cancer: a case study/ Integralidad en la atención a la mujer en la prevención del cáncer de cuello uterino: un estudio de caso  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Realizou-se análise da gestão da atenção, com base na integralidade da assistência à saúde da mulher na prevenção do câncer cérvico-uterino, através de entrevista com duas pacientes atendidas em serviço de saúde da região nordeste do país. Consistiu num estudo de caso onde os dados foram analisados através do Fluxograma Analisador do Modelo de Atenção de um Serviço de Saúde. Em um caso identificou-se a integração dos pontos de atenção, com caráte (more) r integral e no outro a fragmentação total desta. No estudo é percebida a importância de maior atenção do gestor no sentido de melhor planejar, organizar e avaliar as ações nos serviços de atenção saúde da mulher, buscando a eficiência, a eficácia e a efetividade, assegurando que os princípios do Sistema Único de Saúde sejam respeitados. Abstract in spanish Este estudio tuvo como objetivo analizar la gerencia de la atención basado en la integralidad de salud de la mujer en la prevención del cáncer de cuello uterino, usando la entrevista con dos pacientes atendidas en un servicio de salud en la región nordeste brasileña. Se constituye en un estudio caso cuyos datos fueron analizados según el Fluxograma Analizador del Modelo de Atención de un servicio de Salud. En uno de los casos se identificó la integración de los p (more) untos de atención; de tipo integral y, en el otro, la fragmentación total de estos. Se percibe en el estudio la importancia de la mayor atención del gerenciador para poder planear mejor, organizar y evaluar las acciones en los servicios de la salud de las mujeres, en la busqueda de los parámetros de la eficiencia, eficacia y efetividad, garantizando que los principios del Sistema Único de Salud sean cumplidos y respetados. Abstract in english This study aimed at analysing attention-based management based upon women's health integration in the prevention of cervical-uterine cancer, using interviews with two patients who were given care in a healthcare service in the northeast region of Brazil. In this case study the data was analysed according to the Analysis Fluxogram of the Healthcare Attention Model. In one of the cases total integration of attention scores was identified; while in the other total fragmentat (more) ion of attention scores was identified. In this study the relevance of greatest attention was played by the manager in the sense of better planning, organization, and evaluation of the service's interventions in women's healthcare; services that sought efficiency, and effectiveness, assuring that the principles of the Brazilian National Health Care System are respected.

Ximenes Neto, Francisco Rosemiro Guimarães; Cunha, Isabel Cristina Kowal Olm

2006-09-01

334

Strategy of cervical myomectomy under laparoscopy.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate a strategy of laparoscopic excision of a cervical myoma (CM). DESIGN: Prospective study. SETTING: University-affiliated hospital. PATIENT(S): Twenty-eight patients with CM underwent laparoscopic myomectomy. These cases were classified into five types according to the location: [1] anterior cervical myoma (ACM); [2] posterior cervical myoma (PCM); [3] central cervical myoma (CCM); [4] lateral cervical myoma [LCM]; and [5] deep-rooted cervical myoma (DCM). INTERVENTION(S): After preoperative assessment, patients underwent laparoscopic myomectomy. Ligation of the uterine artery and diluted vasopressin injection were performed to decrease bleeding during laparoscopy. MAIN OUTCOME MEASURE(S): Myoma numbers, myoma weight, operative time, estimated blood loss, hospital stay, complication rate. RESULT(S): Most of the lesions were ACM (43%) and PCM (32%). The mean operative time was 121 minutes, mean blood loss was 99 mL, and mean myoma weight was 287 g. The mean hospital stay was 2.2 days. There were no complications. Histopathologic examination showed that all lesions were leiomyoma. Hypermenorrhea, dysmenorrhea, and symptoms of compression improved after the operation. Two infertile patients conceived spontaneously at 1 and 7 months postoperatively, and successfully delivered infants by cesarean section at term. CONCLUSION(S): Surgical treatment of CM is empirically difficult. It is important that the approach be changed according to the location and size of the myoma.

Chang WC; Chen SY; Huang SC; Chang DY; Chou LY; Sheu BC

2010-12-01

335

Severe cervical scoliosis in the fetus.  

UK PubMed Central (United Kingdom)

OBJECTIVE: This study provides prenatal characteristics and postnatal outcomes of patients with severe cervical scoliosis. METHODS: A retrospective analysis of clinical information from cases prenatally diagnosed with severe cervical scoliosis (>90° angulation) in the Fetal Care Center at Cincinnati Children's Hospital Medical Center between 2007 and 2010 was performed. We excluded iniencephaly and tumors of the head or neck. RESULTS: We identified five patients with severe cervical scoliosis. The fetal spine abnormality was diagnosed between 18 and 27 weeks of gestation. Classical cesarean section was recommended in all patients. There were no immediate airway or neurological complications in the delivery room. Extravertebral anomalies were present in four of the five patients. These patients had a more complicated clinical course and three separate syndromes including a complex collagenopathy, heterotaxy, and Klippel-Feil syndrome were identified. One patient had an isolated cervical deformation secondary to a large uterine fibroid with a benign clinical course. None of the infants have required spinal surgery. CONCLUSION: Our patients suggest that connective tissue diseases or heterotaxy may be important risk factors for the development of severe cervical scoliosis. There were no significant long-term complications directly related to cervical scoliosis.

Prada CE; Sellars EA; Spaeth CG; Kline-Fath BM; Crombleholme TM; Hopkin RJ

2011-12-01

336

UTERINE FIBROID TREATMENT  

UK PubMed Central (United Kingdom)

The use of a) an angiotensin-converting enzyme (ACE) inhibitor such as Captopril or Enalapril, b) an angiotensin II-receptor antagonist such as Saralasin or Losartan, or c) a renin inhibitor, such as Remikiren or [N-(pyridyl-3-propionyl)-phenylalanyl-histidyl-(3S,4S) ACHPA-isoleucylamino]-2-methyl-2-dihydroxy-1,3-propane, for the manufacture of a medicament for the treatment of uterine fibroids is disclosed. The ACE inhibitor may be used concomitantly or sequentially with a gonadotropin-releasing hormone agonist such as Buserelin or Goserelin.

AHMED Asif Syed

337

Computed tomography in advanced carcinoma of the uterine cervix  

International Nuclear Information System (INIS)

[en] Computed tomography (CT) and clinical examination including complete evaluation of the true pelvis were performed in 32 patients of whom 2 had possible advanced primary and 30 possible recurrent carcinoma of the uterine cervix. Confirmation of the staging by surgery or autopsy was obtained in 22 patients and by repeat clinical examinations and CT in 10 patients. The CT diagnosis was correct in 29 and the clinical pelvic examination in 25 patients. The results confirm previous reports that CT is a complementary method to pelvic examination in advanced cervical carcinoma. (orig.)

1984-01-01

338

Computed tomography in advanced carcinoma of the uterine cervix  

Energy Technology Data Exchange (ETDEWEB)

Computed tomography (CT) and clinical examination including complete evaluation of the true pelvis were performed in 32 patients of whom 2 had possible advanced primary and 30 possible recurrent carcinoma of the uterine cervix. Confirmation of the staging by surgery or autopsy was obtained in 22 patients and by repeat clinical examinations and CT in 10 patients. The CT diagnosis was correct in 29 and the clinical pelvic examination in 25 patients. The results confirm previous reports that CT is a complementary method to pelvic examination in advanced cervical carcinoma.

Thorvinger, B.; Hauksson, A.; Samuelsson, L.; Trope, C.

1984-01-01

339

Mesonephric adenocarcinoma of the uterine cervix and literature review.  

Science.gov (United States)

Mesonephric adenocarcinoma is a rare type of cervical cancer that derives from mesonephric remnants in the uterine cervix. To the best of our knowledge, this is the 34th case of mesonephric adenocarcinoma in adult women documented in the literature. We present an asymptomatic 64-year-old postmenopausal woman presenting with a suspicious-looking cervix as an incidental finding and diagnosed with a stage IB mesonephric adenocarcinoma of the cervix. This case was managed with radical hysterectomy, bilateral salpingoophorectomy and pelvic lymphadenectomy. The rarity of such cases imposes challenges on the management in terms of diagnosis, prognosis and therapeutic options. PMID:23230242

Anagnostopoulos, Antonios; Ruthven, Stuart; Kingston, Robert

2012-12-10

340

Mesonephric adenocarcinoma of the uterine cervix and literature review.  

UK PubMed Central (United Kingdom)

Mesonephric adenocarcinoma is a rare type of cervical cancer that derives from mesonephric remnants in the uterine cervix. To the best of our knowledge, this is the 34th case of mesonephric adenocarcinoma in adult women documented in the literature. We present an asymptomatic 64-year-old postmenopausal woman presenting with a suspicious-looking cervix as an incidental finding and diagnosed with a stage IB mesonephric adenocarcinoma of the cervix. This case was managed with radical hysterectomy, bilateral salpingoophorectomy and pelvic lymphadenectomy. The rarity of such cases imposes challenges on the management in terms of diagnosis, prognosis and therapeutic options.

Anagnostopoulos A; Ruthven S; Kingston R

2012-01-01

 
 
 
 
341

Spontaneous bleeding from the uterine arteries during pregnancy--problems in diagnosis and therapy--bleeding from uterine arteries during pregnancy.  

Science.gov (United States)

Arterial bleeding, initially negative on MRI, ultrasonography and radiographic angiography, complicated the course of pregnancy with severe and recurrent vaginal and pelvic haemorrhage in the second trimester. Bleeding from the left uterine artery was successfully terminated by angiographic embolisation. No harmful effects on the fetal well-being were recorded after the embolisation. Massive haemorrhage, most probably from the right uterine artery, recurred some days later, and Caesarean section was performed. At postpartal ultrasonography and catheter angiography, massive arterial bleeding from a pseudoaneurysmatic vessel was clearly imaged on the right side of the cervical myometrium and could successfully be treated by radiographic embolisation. Though the primary aetiology of bleeding remains uncertain, it is possible that cervical endometriosis could have been associated with this complication. PMID:17447219

Kirkinen, P; Keski-Nisula, L; Kuoppala, T; Tommola, S; Uotila, J

2007-04-01

342

Spillway and foundation erosion: Predicting erosion threshold  

Energy Technology Data Exchange (ETDEWEB)

This paper summarizes the method that will be used by the Bureau of Reclamation to investigate scour of spillways and dam foundations, and to develop a numerical model to compute the same. In what follows the basis of a unique relationship between the erosive power of water and the ability of earth materials to resist erosion, known as the Erodibility Index Method, is presented. The paper also provides a description of the approach that will be used by the numerical model to calculate the erosive power of plunging, aerated jets. The complimentary paper, Wittler (1995), describes the approach that will be used to investigate the extent of scour of spillways and dam foundations.

Annandale, G.W. [HDR Engineering, Inc., El Dorado Hills, CA (United States); Wittler, R.J.; Mefford, B.W. [Bureau of Reclamation, Denver, CO (United States)] [and others

1995-12-31

343

METHOD FOR TREATMENT OF UTERINE FIBROID TUMORS  

UK PubMed Central (United Kingdom)

Various injectable or insertable uterine fibroid treatment formulations are provided, which comprise a uterine fibroid treatment agent in an amount effective to cause shrinkage or elimination of uterine fibroids. The injectable or insertable formulations are typically solids, semi-solids or high-viscosity fluids. Other aspects of the invention are directed to systems and methods for treatment of uterine fibroids.

MCINTYRE JON T; MADENJIAN ARTHUR

344

Incidence trends in invasive uterine cervix cancer and carcinoma in situ in Incheon, South Korea.  

UK PubMed Central (United Kingdom)

INTRODUCTION: This study examined trends of invasive uterine cervix cancer and carcinoma in situ (CIS) in terms of the incidence and mortality in Incheon over a twelve year period. METHODS: Uterine cervical cancer data were retrieved from the Incheon Cancer Registry (ICR) and Korea Central Cancer Registry (KCCR) from 1997 to 2008. The time trends in age-standardized incidence rates (ASR) of invasive uterine cervix cancer patients and CIS were calculated and compared with the nation-wide cancer registry data for each year. Mortality/incidence (M/I) ratios according to age and the incidence of the pathologic subtype in Incheon each year were also examined, along with an international comparison. RESULTS: A total of 3,096 cases of invasive cervical cancer and 2,079 cases of carcinoma in situ were analyzed from 1997 to 2008. The time trend incidence of the total ASR in uterine cervical cancer decreased from 25.7 in 1997 to 13.4 in 2008, but the incidence of CIS increased from 7.6 to 15.8 in same period. In invasive cancers, the age-specific incidence rates were highest in those in their sixties while patients in their forties showed highest CIS values. The mortality rate in ICR was 3.7 from 1998 to 2002. Compared to the other countries which have high risk factors for cervix cancer, the peak incidence zone was different in Incheon. CONCLUSION: The ICR showed a decrease in the incidence of invasive cervical cancer that was similar to the nation-wide data. An early increase zone is a characteristic pattern in the age specific incidence curve. Early screening and a vaccination program should be activated for prevention of young age cervical cancer.

Boo YK; Kim WC; Lee HY; Leem JH; Lee MH; Leem JS

2011-01-01

345

45: Dose, volume and complication of the rectum in the uterine cervix (analysis using a diagnostic CT)  

International Nuclear Information System (INIS)

Fifty-four patients, with the uterine cervical cancer, were analyzed about the relationship of dose-volume of the rectum and late rectal complication. To evaluate the dose-volume of the rectum, calculated from diagnostic CT image, complication probability factor (CPF) was calculated. As a result, CPF can be used for the optimization of treatment planning. 8 refs.; 3 figs.; 1 table.

1987-01-01

346

Pyomyoma after uterine artery embolization.  

UK PubMed Central (United Kingdom)

BACKGROUND: Pyomyoma (suppurative leiomyoma of the uterus) is a rare condition resulting from infarction and infection of a leiomyoma. It can lead to sepsis and death unless treated with antibiotics and aggressive surgical intervention. CASE: A 47-year-old multigravid woman with symptomatic uterine leiomyomas presented with fever, pelvic pain, and leukocytosis after uncomplicated uterine artery embolization. Pyomyoma was suspected after computed tomography scan demonstrated an enlarged, heterogeneous uterus containing copious myometrial air. She underwent supracervical hysterectomy, lysis of adhesions, and right salpingo-oophorectomy. CONCLUSION: Surgical management of pyomyoma may be necessary early in the management of pyomyoma after uterine artery embolization.

Rosen ML; Anderson ML; Hawkins SM

2013-02-01

347

Uterine rupture after hysteroscopic resection of uterine septum.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To describe a patient who underwent hysteroscopic resection of a uterine septum for recurrent miscarriage. The subsequent labor caused uterine rupture. DESIGN: Case report. SETTING: Academic medical center. PATIENT(S): A 37-year-old nullipara with three previous miscarriages. INTERVENTION(S): Resection of the septum by cutting diathermy using the operating hysteroscope. MAIN OUTCOME MEASURE(S): Pregnancy and delivery. RESULT(S): The patient had an uneventful pregnancy and spontaneous labor at 41 weeks. Cesarean section was performed because of suspected fetal distress. During cesarean section, the uterus was ruptured transversely along the fundus at the line of the attachment of the septum. CONCLUSION(S): When fetal distress occurs after previous uterine surgery, uterine rupture must be considered as a possible cause and appropriate treatment is necessary.

Kerimis P; Zolti M; Sinwany G; Mashiach S; Carp H

2002-03-01

348

Uterine Artery Anatomy Relevant to Uterine Leiomyomata Embolization  

International Nuclear Information System (INIS)

To categorize the anatomic variants of uterine arteries, and determine the incidence of menopausal symptoms where the tubo-ovarian branches were seen prior to embolization. Between July 1997 and June 2000, 257 (n = 257) uterine fibroid embolizations were performed at our institution. Arteriograms were retrospectively evaluated. Uterine arteries were classified into groups: type I (the uterine artery as first branch of the inferior gluteal artery), type II (the uterine artery as second or third branch of the inferior gluteal artery), type III (the uterine artery, the inferior gluteal and the superior gluteal arteries arising as a trifurcation), type IV (the uterine artery as first branch of the hypogastric artery), inconclusive, or not studied. Tubo-ovarian branches were recorded if visualized prior to and/or after embolization. Menopausal symptoms were recorded (n = 175 at 3 months, n = 139 at 6 months, n = 98 at 1 year, n = 22 at 2 years) using written questionnaires. Five hundred and fourteen uterine arteries (n = 514) were evaluated. There were 38% classifiable types, 23% inconclusive, and 39% not studied. Classification was as follows: type I, 45%; type II, 6%; type III, 43%; type IV, 6%. Among 256 patients, tubo-ovarian arteries were seen in 36 prior to embolization, but not afterwards. In this group, 25 patients reported transient menopausal symptoms (hot flashes, amenorrhea). Five patients did not report any menopausal symptoms. Six patients did not answer the questionnaires. Type I is the most common type of anatomy, followed by type III. The tubo-ovarian arteries may be visualized prior to and/or after embolization. The embolization was monitored to avoid embolization of the tubo-ovarian branches. Menopausal symptoms were transient all patients when the tubo-ovarian branches were seen prior to embolization.

2003-01-01

349

Prevalence and predictors of cervical involvement in psoriatic spondyloarthropathy.  

UK PubMed Central (United Kingdom)

Cervical spondylitis has been reported in 35%-75% of patients with psoriatic arthritis (PsA), and this likely represents the highest frequency of cervical involvement among the spondyloarthropathies. Although 2 patterns of cervical spondylitis have been recognized in PsA, this may reflect a lack of a satisfactory definition of cervical spondylitis in PsA. In a retrospective cross-sectional study, we analyzed the clinical records of 100 consecutive patients recruited at a single university hospital who were diagnosed as having psoriatic spondyloarthropathy on the basis of radiographic sacroiliitis. All patients were involved in a clinicoradiologic study of the cervical column to evaluate the frequency and the predictors of this involvement. Forty-one patients showed radiographic signs of cervical involvement and 24 of them (58.5%) complained of cervical pain and stiffness, whereas 17 (41.5%) had radiologic disease with no symptoms. Arthritis duration (odds ratio, 1.08; 95% confidence interval, 0.99-1.19; p < 0.05) and peripheral erosive disease (odds ratio, 2.5; 95% confidence interval, 1.91-6.92; p < 0.05) were found to be associated with cervical spondylitis development. This study showed a high frequency of cervical spondylitis among patients with psoriatic spondyloarthropathy, confirming previous reports. Although none of our patients developed neurologic sequelae, this report also showed that clinical symptoms of cervical pain and stiffness are not a universal predictor of involvement of the cervical spine, and therefore, patients with PsA with longer disease duration and erosive disease should be screened radiologically to detect those cervical lesions (i.e., atlantoaxial subluxation) with potential catastrophic complications.

Queiro R; Sarasqueta C; Torre JC; Tinture T; López-Lagunas I

2002-02-01

350

Prevalence and predictors of cervical involvement in psoriatic spondyloarthropathy.  

Science.gov (United States)

Cervical spondylitis has been reported in 35%-75% of patients with psoriatic arthritis (PsA), and this likely represents the highest frequency of cervical involvement among the spondyloarthropathies. Although 2 patterns of cervical spondylitis have been recognized in PsA, this may reflect a lack of a satisfactory definition of cervical spondylitis in PsA. In a retrospective cross-sectional study, we analyzed the clinical records of 100 consecutive patients recruited at a single university hospital who were diagnosed as having psoriatic spondyloarthropathy on the basis of radiographic sacroiliitis. All patients were involved in a clinicoradiologic study of the cervical column to evaluate the frequency and the predictors of this involvement. Forty-one patients showed radiographic signs of cervical involvement and 24 of them (58.5%) complained of cervical pain and stiffness, whereas 17 (41.5%) had radiologic disease with no symptoms. Arthritis duration (odds ratio, 1.08; 95% confidence interval, 0.99-1.19; p < 0.05) and peripheral erosive disease (odds ratio, 2.5; 95% confidence interval, 1.91-6.92; p < 0.05) were found to be associated with cervical spondylitis development. This study showed a high frequency of cervical spondylitis among patients with psoriatic spondyloarthropathy, confirming previous reports. Although none of our patients developed neurologic sequelae, this report also showed that clinical symptoms of cervical pain and stiffness are not a universal predictor of involvement of the cervical spine, and therefore, patients with PsA with longer disease duration and erosive disease should be screened radiologically to detect those cervical lesions (i.e., atlantoaxial subluxation) with potential catastrophic complications. PMID:17039196

Queiro, Rubén; Sarasqueta, Cristina; Torre, Juan C; Tinture, Tomás; López-Lagunas, Isaac

2002-02-01

351

Should helical tomotherapy replace brachytherapy for cervical cancer? Case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Stereotactic body radiation therapy (SBRT) administered via a helical tomotherapy (HT) system is an effective modality for treating lung cancer and metastatic liver tumors. Whether SBRT delivered via HT is a feasible alternative to brachytherapy in treatment of locally advanced cervical cancer in patients with unusual anatomic configurations of the uterus has never been studied. Case Presentation A 46-year-old woman presented with an 8-month history of abnormal vaginal bleeding. Biopsy revealed squamous cell carcinoma of the cervix. Magnetic resonance imaging (MRI) showed a cervical tumor with direct invasion of the right parametrium, bilateral hydronephrosis, and multiple uterine myomas. International Federation of Gynecology and Obstetrics (FIGO) stage IIIB cervical cancer was diagnosed. Concurrent chemoradiation therapy (CCRT) followed by SBRT delivered via HT was administered instead of brachytherapy because of the presence of multiple uterine myomas with bleeding tendency. Total abdominal hysterectomy was performed after 6 weeks of treatment because of the presence of multiple uterine myomas. Neither pelvic MRI nor results of histopathologic examination at X-month follow-up showed evidence of tumor recurrence. Only grade 1 nausea and vomiting during treatment were noted. Lower gastrointestinal bleeding was noted at 14-month follow-up. No fistula formation and no evidence of haematological, gastrointestinal or genitourinary toxicities were noted on the most recent follow-up. Conclusions CCRT followed by SBRT appears to be an effective and safe modality for treatment of cervical cancer. Larger-scale studies are warranted.

Hsieh Chen-Hsi; Wei Ming-Chow; Hsu Yao-Peng; Chong Ngot-Swan; Chen Yu-Jen; Hsiao Sheng-Mou; Hsieh Yen-Ping; Wang Li-Ying; Shueng Pei-Wei

2010-01-01

352

Uterine arterial embolization for uterine leiomyoma: efficacy and clinical outcome  

Energy Technology Data Exchange (ETDEWEB)

To determine the efficacy and clinical outcome of uterine arterial embolization as a new approach to the management of uterine leiomyomas. Uterine arterial embolization was performed in 21 patients aged 26-62(mean, 42) years. Twenty of these had menorrhagia, dysmenorrhea, and mass-related symptoms (low abdominal discomfort, backache, urinary frequency, etc.) and one was diagnosed incidentally. Bilateral uterine arteries were selected individually and polyvinyl alcohol and/or gelfoam was used as an embolic material. Nineteen patients were followed up after embolization. Seventeen (89.5 %)reported satisfactory improvement of symptoms and follow-up sonography three months later showed a 58.5 % reduction in mean myoma volume. In 17 patients (89.5 %), the menstrual cycle returned to normal. All patients experienced pain after the procedure and other complications were vaginal bleeding (26.3 %) and fever (23.8 %). Uterine arterial embolization represents a new approach to the management of uterine leiomyoma-related symptoms. Further investigations and long-term follow-up are, however, enquired.

Park, Jeong Seon; Lee, Do Yon; Kim, Yong Tae; Park, Ki Hyun; Park, Yong Won; Cho, Jae Sung; Kim, Myung Jun [Yonsei Univ. College of Medicine, Seoul (Korea, Republic of); Won, Je Hwan [Ajou Univ. College of Medicine, Suwon (Korea, Republic of); Kang, Byung Chul [Ewha Womans Univ. College of Medicine, Seoul (Korea, Republic of)

1999-09-01

353

[Uterine rupture: 50 cases  

UK PubMed Central (United Kingdom)

The author reports 50 cases of rupture of the uterus among 11,060 labors i.e. one rupture per 220 labors. This study shows that rupture of the uterus occurs in women in poor socio-economic circumstances. Uterine scarring seems to be a more important factor than age and multiparity. Traumatic rupture is also common, resulting from obstetric procedures but above all from abdominal expression, most often performed outside hospital. Rupture of the uterus may present in many different ways. It was diagnosed in 32 cases before delivery while in 18 cases it was discovered during cesarean section or extraction of retained placenta. The lower segment was the elective site of rupture. With regard to treatment, suture was possible in 42 cases while hysterectomy proved necessary in the other 8 cases in view of the poor local tissue state. The prognosis remains gloomy, with a high risk of maternal death and, above all, a 58% fetal death rate.

el Mansouri A

1995-04-01

354

Uterine fibroid treatment  

UK PubMed Central (United Kingdom)

PCT No. PCT/GB95/01301 Sec. 371 Date Feb. 19, 1997 Sec. 102(e) Date Feb. 19, 1997 PCT Filed Jun. 6, 1994 PCT Pub. No. WO95/33454 PCT Pub. Date Dec. 14, 1995The use of a) an angiotensin-converting enzyme (ACE) inhibitor such as Captopril or Enalapril, b) an angiotensin II-receptor antagonist such as Saralasin or Losartan, or c) a renin inhibitor, such as Remikiren or [N-(pyridyl-3-propionyl)-phenylalanyl-histidyl-(3S,4S) ACHPA-isoleucylamino]-2-methyl-2-dihydroxy-1,3-propane, for the manufacture of a medicament for the treatment of uterine fibroids is disclosed. The ACE inhibitor may be used concomitantly or sequentially with a gonadotropin-releasing hormone agonist such as Buserelin or Goserelin.

AHMED ASIF SYED

355

Erosion-corrosion; Erosionkorrosion  

Energy Technology Data Exchange (ETDEWEB)

A literature study on erosion-corrosion of pipings in the nuclear industry was performed. Occurred incidents are reviewed, and the mechanism driving the erosion-corrosion is described. Factors that influence the effect in negative or positive direction are treated, as well as programs for cont