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1

Uterine didelphys with cervical incompetence  

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Full Text Available Uterine didelphys represents a uterine malformation where the uterus is present as a paired organ. There is presence of double uterine bodies with two separate cervices, and often a double or septate vagina as well. We report a case of single pregnancy in the right sided uterine body of a didelphic uterus with cervical incompetence.

Aher Gautam S, Gavali Urmila G, Kulkarni Meghana

2013-04-01

2

Molecular events in uterine cervical cancer  

OpenAIRE

OBJECTIVE: To review the literature regarding the molecular events which occur in the development of uterine cervical cancer, with particular reference to human papillomavirus (HPV) infection. METHODOLOGY: Bibliographic searches of Medline and the ISI citation databases using appropriate keywords, including the following: papillomavirus, cervix, pathology, cyclin, chromosome, heterozygosity, telomerase, smoking, hormones, HLA, immune response, HIV, HSV, EBV. CONCLUSIONS: It has become ...

Southern, S. A.; Herrington, C. S.

1998-01-01

3

Uterine artery chemoembolization: its application in treating cervical pregnancy  

International Nuclear Information System (INIS)

Objective: To discuss the feasibility and safety of uterine artery chemoembolization in the treatment of cervical pregnancy. Methods: During the period of Sep. 2005-Dec. 2007, uterine artery chemoemboliztion was performed in 12 patients with cervical pregnancy in the authors' hospital. Via bilateral uterine arteries 100 mg MTX and 80,000 U Gentamycin were infused separately, after that the bilateral uterine arteries were embolized with gelfoam. Cleaning of the uterus and the cervix uteri was carried out in 24 -72 h after the procedure. Results: The technical success rate of bilateral uterine artery chemoembolization was 100%. The blood loss was 50-100 ml (mean 65 ml) during the procedure of cleaning the uterus and the cervix uteri. No serious complications occurred. Conclusion: Uterine artery chemoembolization is an effective and safe treatment for cervical pregnancy, which can greatly avoid unnecessary uterectomy and preserve fertility function. (authors)

4

Carbon ion therapy for uterine cervical cancer  

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Between June 1995 and August 2003, the four phase I/II dose escalation studies of carbon ion radiotherapy for locally advanced uterine cancer have been performed. Forty-four patients received carbon ion radiotherapy in 24 fixed fractions over 6 weeks (9403 and 9702) and 36 patients received in 20 fixed fractions over 5 weeks (9704 and 9902). The median tumor size in this population was 6.5 cm in diameter. In the beginning of these studies, 8 patients developed grade 4 late morbidity of the rectum and sigmoid colon. These patients underwent colostomy and they are all alive with disease free except one local recurrence. The technique of cone down irradiation to the primary lesion was improved and now there are no severe morbidity in the rectum and sigmoid colon. On the other hand, the tumor control rate increased as the total dose was escalated. The overall local control rate were 71% and 63% at 5 year for stage IIIB and IVA cervical squamous cell carcinoma, and 54% at 4 year for stage III and IVA cervical adenocarcinoma. Carbon ion radiotherapy is considered to be effective for the bulky squamous cell carcinoma and adenocarcinoma which are hard to cure in conventional radiotherapy. (author)

5

A Case of Uterine Cervical Cancer Presenting with Granulocytosis  

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Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients with renal cell carcinoma. Granulocytosis occurs because of production of G-CSF, GM-CSF and IL-6. Uterine cervical carcinoma with granulocytosis as a paraneoplastic syndrome, however, has been rarely reported. We recently witnessed a case of invasive squamous cell carcinoma of the uterine cervix with granul...

Ahn, Heui June; Park, Yeon Hee; Chang, Yoon Hwan; Park, Sun Hoo; Kim, Min-suk; Ryoo, Baek Yeol; Yang, Sung Hyun

2005-01-01

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Isolated Humeral Metastasis in Uterine Cervical Cancer: A Rare Entity  

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Bone metastasis in cancer of uterine cervix, especially in the form of isolated bone involvement is a rare manifestation. Herein, we report the first case of isolated humeral metastasis in a known case of locally advanced cervical cancer. A fifty-six-year old female presented with International Federation of Gynecology and Obstetrics (FIGO) Stage IV A squamous cell carcinoma of uterine cervix. She was treated with a combination of radiation and chemotherapy and then total abdominal hysterecto...

Malek, Mahrooz; Kanafi, Alireza Rajabzadeh; Pourghorban, Ramin; Nafisi-moghadam, Reza

2012-01-01

7

Uterine cervical cancer. Preoperative staging with magnetic resonance imaging  

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The treatment of uterine cervical carcinoma is largely dependent on the tumor stage. Despite significant inaccuracies in the clinical examination, uterine cervical cancer remains the only gynecological form of cancer still largely staged according to clinical findings. Although imaging is still not included in the staging the recently published revised FIGO (Federation International de Gynecologie et d'Obstetrique) system encourages the use of modern cross-sectional imaging (magnetic resonance imaging MRI and computed tomography CT). Due to its high soft tissue contrast MRI allows excellent non-invasive assessment of the cervix with direct tumor delineation as well as assessment of the prognosis based on morphological factors. Studies in the literature report an accuracy of 93% for MRI in the preoperative assessment of tumor size and in the differentiation of operable from advanced cervical cancer. Therefore MRI is considered to be the optimal modality for diagnostic evaluation starting from FIGO stage IB1, for radiation therapy planning, and for exclusion of recurrence in follow-up. In this paper we give an overview of the role of magnetic resonance imaging in preoperative staging of uterine cervical cancer. (orig.)

8

KAMPILLAKADI GHRITA IN GARBHASHAYA GREEVA GATA VRANA (CERVICAL EROSION)  

OpenAIRE

Certain diseases may not be life threatening but troublesome and irritating to an individual in day to day routine activity. “Cervical erosion” is one among them increasing day by day and demanding greater concern over it. It is a benign condition but if left untreated may leads up to infertility and predisposes to cervical malignancy. Cauterization is the known treatment for cervical erosion but chances of recurrence of the disease are high. Keeping this fact in mind the present clinical...

Dhiman Kamini; Parmar Meena; Dhiman K.S.

2012-01-01

9

Pharmacokinetics of adriamycin vaginal suppository on uterine cervical cancer  

International Nuclear Information System (INIS)

Vaginal suppositories of Adriamycin (ADM, 5 mg), for reducing the capacity for repair from sublethal damage of X-ray-irradiated cells, were prepared using Wipepsol S-55 as the vehicle, and were intravaginally administered to patients with advanced uterine cervical cancer, and their pharmacokinetics and clinical effects were studied. The ADM concentration in the uterine cervical cancer tissues indicated high levels (17 to 566 ?g/g), and migration into the cardinal ligament and regional lymph nodes was noted. However, little ADM was detected in serum (0 to 0.14 ?g/g), probably because of its molecular weight and excellent tissue absorbance, and no side effects, such as cardiotoxicity and myelosuppression due to consecutive administration were detected. Histologically, the effect obtained when administered alone was limited, administration in combination with radiotherapy being more effective. Accordingly, radiotherapy of advanced uterine cervical cancer with concomitant administration of ADM vaginal suppositories seems to bring about a more powerful antitumoral effect with fewer systemic side effects. (author)

10

Recurrent uterine cervical carcinoma: spectrum of imaging findings  

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Uterine cervical carcinoma is one of the most common malignant tumors occurring in females. After primary treatment, patients are usually followed up with CT or MRI and the findings of these modalities may be the first sign of recurrent disease. Because earlier additional treatment by chemotherapy or radiation therapy may improve the prognosis, the early detection of recurrent cervical carcinoma is clinically important. In this article, we review the CT and MR imaging findings of recurrent uterine cervical carcinoma, and assign them to one of four groups: a) recurrence at the primary site, involving the intrapelvic organs, b) extension to the pelvic side-wall, c) metastases to pelvic and extrapelvic lymph nodes, or d) metastases to distant organs. A further contribution of CT and MR imaging is the detection of hydronephrosis due to ureteral obstruction. The cases in each group are illustrated and discussed, and since an awareness of the spectrum of imaging findings of recurrent cervical carcinoma is likely to lead to its early detection, radiologists should be familiar with the information presented. (author)

11

Superselective intraarterial chemotherapy into bilateral uterine arteries in uterine cervical carcinomas  

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To assess the efficacy of superselective intra-arterial chemotherapy(SSIAC) via the bilateral uterine arteries in cases of cervical carcinoma. Eighteen patients with stage 2 a(n=10), 2 b(n=7), or 3 a(n=1) cervical carcinoma underwent one(n=2) or two(n=16) courses of preoperative SSIAC with Vincristine, Cisplatin, and Mitomycin C. We estimated the extent of reduction of tumor volume and improvement of stage, comparing pre-SSIAC MRI to postoperative results. Tumor vascularity, as seen on uterine arteriography, and procedural complications, were also evaluated. A marked reduction in tumor volume was observed in all patients, an average reduction volume of 94.7%. Improvement of stage was noted in 16 patients, and in six of these, no residual viable tumor or microinvasive residual tumor was seen. On angiography, tumor hypervascularity was demonstrated in seven patients, but its degree was not substantially related to therapeutic response. In no case did significant systemic complications of result from chemotherapy; in one patient, however, we experienced a serious complication of necrotizing cystitis due to malpositioning of a catheter in the superior vesical artery. SSIAC via the bilateral uterine arteries is an effective complementary modality for the treatment of various stages of cervical carcinoma

12

Short-course palliative radiotherapy for uterine cervical cancer  

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The purpose of this retrospective study was to evaluate the efficacy and feasibility of short-course hypofractionated radiotherapy (RT) for the palliation of uterine cervical cancer. Seventeen patients with cancer of the uterine cervix, who underwent palliative hypofractionated 3-dimensional conformal radiotherapy between January 2002 and June 2012, were retrospectively analyzed. RT was delivered to symptomatic lesions (both the primary mass and/or metastatic regional lymph nodes). The total dose was 20 to 25 Gy (median, 25 Gy) in 5 Gy daily fractions. The median follow-up duration was 12.2 months (range, 4 to 24 months). The median survival time was 7.8 months (range, 4 to 24 months). Vaginal bleeding was the most common presenting symptom followed by pelvic pain (9 patients). The overall response rates were 93.8% and 66.7% for vaginal bleeding control and pelvic pain, respectively. Nine patients did not have any acute side effects and 7 patients showed minor gastrointestinal toxicity. Only 1 patient had grade 3 diarrhea 1 week after completion of treatment, which was successfully treated conservatively. Late complications occurred in 4 patients; however, none of these were of grade 3 or higher severity. Short-course hypofractionated RT was effective and well tolerated as palliative treatment for uterine cervical cancer.

13

Short-course palliative radiotherapy for uterine cervical cancer  

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The purpose of this retrospective study was to evaluate the efficacy and feasibility of short-course hypofractionated radiotherapy (RT) for the palliation of uterine cervical cancer. Seventeen patients with cancer of the uterine cervix, who underwent palliative hypofractionated 3-dimensional conformal radiotherapy between January 2002 and June 2012, were retrospectively analyzed. RT was delivered to symptomatic lesions (both the primary mass and/or metastatic regional lymph nodes). The total dose was 20 to 25 Gy (median, 25 Gy) in 5 Gy daily fractions. The median follow-up duration was 12.2 months (range, 4 to 24 months). The median survival time was 7.8 months (range, 4 to 24 months). Vaginal bleeding was the most common presenting symptom followed by pelvic pain (9 patients). The overall response rates were 93.8% and 66.7% for vaginal bleeding control and pelvic pain, respectively. Nine patients did not have any acute side effects and 7 patients showed minor gastrointestinal toxicity. Only 1 patient had grade 3 diarrhea 1 week after completion of treatment, which was successfully treated conservatively. Late complications occurred in 4 patients; however, none of these were of grade 3 or higher severity. Short-course hypofractionated RT was effective and well tolerated as palliative treatment for uterine cervical cancer.

Kim, Dong Hyun; Lee, Ju Hye; Ki, Yong Kan; Kim, Won Taek; Park, Dahl; Kim, Dong Won [Dept. of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital, Busan (Korea, Republic of); Nam, Ji Ho; Jeon, Sang Ho [Dept. of Radiation Oncology, Pusan National University Yangsan Hospital, Yangsan (Korea, Republic of)

2013-12-15

14

Late intestinal adverse effects of radiotherapy for uterine cervical cancer  

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We investigated the incidence and clinical appearance of late adverse intestinal effects in 88 patients treated with postoperative radiotherapy and 46 patients treated with radiotherapy alone for uterine cervical cancer. In the postoperative radiotherapy group, colitis, ileus and bowel fistules were seen in 13 patients (14.8%), 8 (9.1%), and 3 (3.4%) of the patients, respectively. Of these patients, 11 (12.5%) needed to have surgical therapy for these adverse effects. In the radiation alone group, 18 patients (39.1%) had colitis and 2 (4.3%) had ileus; of them, 2 patients (4.3%) needed to have surgical therapy. The higher incidence of so severe adverse effects as to require surgical therapy in the postoperative radiotherapy group indicates that adhesion caused by operation might have caused the occurrence of these adverse effects. Four of a total of 134 patients died of causes which might be attributable to irradiation. In 61 patients treated by radical hysterectomy without postoperative radiotherapy, intestinal adverse effects were not found. These results indicate that late intestinal adverse effects after radiotherapy are likely to occur in some cases very severely; therefore, careful consideration is necessary in the decision to use radiotherpay for uterine cervical cancer. (J.P.N.).

Tsukada, Seiji; Yamamoto, Yasuaki; Kaneko, Toru; Maruhashi, Toshihiro; Takahashi, Takeshi (Niigata Cancer Center Hospital (Japan))

1993-06-01

15

Oxidative status shifts in uterine cervical incompetence patients.  

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Uterine cervical incompetence (UCI) is a pregnancy complication affecting about 10% of the pregnancies in the western world. Studying the etiology of the UCI requires a specific approach adequate for this highly heterogenous syndrome. Oxidative status disorders are associated with various pathologies, including pregnancy complications. As such, general oxidative status profiling is a promising methodology to treat UCI. We aimed at assaying the closely interrelated oxidative status markers in the uterine cervical incompetence patients by means of the systems biology-oriented approach. Chemiluminescent assay, circulating thioredoxin 1 protein, uric acid, and homocysteine level measurements were used to assess the character of the oxidative status regulation in the UCI patients. We found UCI to be associated with the atypical plasma oxidative status deregulation; UCI plasma samples demonstrated lowered proneness to the pro-oxidative processes, and this was not due to the excessive antioxidant activity. There were neither signs of oxidative stress nor destructive pro-oxidant feedforward circuit locking in the UCI group. We also report increased circulating levels of uric acid in the UCI patients. PMID:24304328

Zolotukhin, Petr; Aleksandrova, Anzhela; Goncharova, Anna; Shestopalov, Aleksandr; Rymashevskiy, Aleksandr; Shkurat, Tatyana

2014-04-01

16

Automatic image quality assessment for uterine cervical imagery  

Science.gov (United States)

Uterine cervical cancer is the second most common cancer among women worldwide. However, its death rate can be dramatically reduced by appropriate treatment, if early detection is available. We are developing a Computer-Aided-Diagnosis (CAD) system to facilitate colposcopic examinations for cervical cancer screening and diagnosis. Unfortunately, the effort to develop fully automated cervical cancer diagnostic algorithms is hindered by the paucity of high quality, standardized imaging data. The limited quality of cervical imagery can be attributed to several factors, including: incorrect instrumental settings or positioning, glint (specular reflection), blur due to poor focus, and physical contaminants. Glint eliminates the color information in affected pixels and can therefore introduce artifacts in feature extraction algorithms. Instrumental settings that result in an inadequate dynamic range or an overly constrained region of interest can reduce or eliminate pixel information and thus make image analysis algorithms unreliable. Poor focus causes image blur with a consequent loss of texture information. In addition, a variety of physical contaminants, such as blood, can obscure the desired scene and reduce or eliminate diagnostic information from affected areas. Thus, automated feedback should be provided to the colposcopist as a means to promote corrective actions. In this paper, we describe automated image quality assessment techniques, which include region of interest detection and assessment, contrast dynamic range assessment, blur detection, and contaminant detection. We have tested these algorithms using clinical colposcopic imagery, and plan to implement these algorithms in a CAD system designed to simplify high quality data acquisition. Moreover, these algorithms may also be suitable for image quality assessment in telemedicine applications.

Gu, Jia; Li, Wenjing

2006-03-01

17

Histological study on radiosensitivity of uterine cervical cancer  

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Primary lesions in 80 cases of uterine cervical cancer were experimentally irradiated with 1000 R of telecobalt, and after 7 days, evaluation of their sensitivity was done. Since histological study of a given dose in a given period is indispensable, the dose of 1000 R and evaluation on the 7th day is clinically useful. A considerable correlation was noted between the level of sensitivity evaluated on the basis of our conventional histological criteria and the prognosis. But on the other hand, some gap was noted and an explanation for this was sought. The relationship between the interstitial reactions and the sensitivity was studied in 50 cases with uterine cervical cancer. In the high-sensitivity group, an abundant formation of granulation with numerous capillaries and a variety of acute exudative inflammations were found, and the lesion in the cancer nest showed a change, a so-called acute necrotic inflammation. Histological criteria for radiosensitivity were established by considering changes in both the parenchyma and stroma of the tumor, as mentioned above. Namely, the change in the parenchyma of the tumor considered to have good sensitivity are as follows: a) swelling and degeneration of the cancer cells are marked and diffuse, b) cancer nest shows the significant decrease in size, and c) viable cells and normal mitosis are few in the fundus of the cancer nest, etc. On the other hand, the changes of the stroma of the tumor are as follows: a) a large number of neor are as follows: a) a large number of neutrocytes, acidocytes, histocytes and mast cells are recognized, b) plenty of capillaries exist and fresh reticular granulations are found, and c) destruction of the fundus of the cancer nest and differentiation of the cancer nest are marked, etc. (S. HAMADA)

18

Pelvic insufficiency fracture after definitive radiotherapy for uterine cervical cancer: retrospective analysis of risk factors  

OpenAIRE

The purpose of this study is to determine the incidence, clinical characteristics and risk factors of postradiation pelvic insufficiency fracture (PIF) in women with uterine cervical cancer. We reviewed the medical records of 126 patients who received definitive radiotherapy (RT) for uterine cervical cancer between 2003 and 2009 at our institution. Among them, 99 patients who underwent at least one computed tomography (CT) or magnetic resonance imaging of the pelvis during their follow-up at ...

Uezono, Haruka; Tsujino, Kayoko; Moriki, Keno; Nagano, Fumiko; Ota, Yosuke; Sasaki, Ryohei; Soejima, Toshinori

2013-01-01

19

EARLY POSTOPERATIVE OUTCOMES IN PATIENTS WITH UTERINE CERVICAL CANCER  

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Full Text Available BACKGROUND: Uterine cervical cancer still presents high percentages of locally advanced tumors on diagnosis due to the lack of screening programs. The multidisciplinary approach in these cases requires neoadjuvant radio-chemotherapy followed in selected cases by surgery. The aim of this study was the assessment of early postoperative outcomes in a consecutive series of cervical cancer patients. METHODS: We performed a comparative analysis in terms of patients and tumor characteristics, type of surgery and postoperative complications on 83 patients with radical surgery divided in terms of neoadjuvant treatment protocol. Two groups were designed: group A, patients who underwent neoadjuvant therapy (n=38; 45.78% and group B, patients operated without neoadjuvant therapy (n=45; 54.22%. RESULTS: The patients mean age was 54.1±11.6 years old. Most cases on diagnosis were stage IIB (41 cases, 49.39% followed by stage IB (24 cases, 28.9%. Neoadjuvant treatment was performed in 38 patients (45.78% (stage IIA – 1 patient, IIB – 31 patients, IIIA – 1 patient and IIIB – 5 patients, with a complete response in 16 (42.1%. Most common intervention was type II radical hysterectomy with pelvic lymphadenectomy in 54 cases (65%. There was no difference in terms of deep vein thrombosis, postoperative urinary and medical morbidity. Digestive complications were relatively higher in neoadjuvant group (28.94% in group A vs. 6.66% in group B, P=0.008 with a longer hospitalization (8.1±2.7 days for group A vs. 6.6±1.6 for group B, P=0.01. CONCLUSION: Radical hysterectomy is a relatively safe technique in terms of postoperative morbidity for patients with cervical cancer despite the use of neoadjuvant therapy. This provides the chance for cure in early stages and a local control for more advanced cases.

M?d?lina Gavrilescu

2013-09-01

20

KAMPILLAKADI GHRITA IN GARBHASHAYA GREEVA GATA VRANA (CERVICAL EROSION  

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Full Text Available Certain diseases may not be life threatening but troublesome and irritating to an individual in day to day routine activity. “Cervical erosion” is one among them increasing day by day and demanding greater concern over it. It is a benign condition but if left untreated may leads up to infertility and predisposes to cervical malignancy. Cauterization is the known treatment for cervical erosion but chances of recurrence of the disease are high. Keeping this fact in mind the present clinical study has been undertaken. The total effect of drug was evaluated on the basis of signs and symptoms after completion of therapy. The data obtained in clinical study before and after treatment was expressed in terms of Mean, Standard Deviation (+SD and Standard Error (+SE. Group-I revealed better results than Group-II over total criteria of assessment.

Dhiman Kamini

2012-04-01

21

Radiotherapy results for recurrent uterine cervical cancer after surgery  

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To evaluate prognostic factors and survival rates of the patients who received radiation therapy for locally recurrent uterine cervical cancer after curative surgery. Between October 1983 and July 1996, fifty three patients who received radiation therapy for locally recurrent cervical cancer after curative surgery at the Department of Therapeutic Radiology, Kangnam St. Mary's Hospital, The Catholic University of Korea were analysed retrospectively. Age at diagnosis ranged from 33 to 69 years (median 53 years). Pathological analysis showed that forty five (84.9%) patients had squamous cell carcinoma, seven (13.2%) patients had adenocarcinoma, and one (1.9%) patient had adenosquamous cell carcinoma. The interval between hysterectomy and tumor recurrence ranged from 2 months to 25 years (mean 34.4 months). The recurrent sites were vaginal stump in 41 patients (77.4%) and pelvic side wall in 12 patients (22.6%). Recurrent tumor size was divided into two groups: less than 3 cm in 43 patients (81.1%) and more than 3 cm in 10 patients (18.9%). External beam irradiation of whole pelvis was done first up to 46.8 Gy to 50.4 Gy in 5 weeks to 6 weeks, followed by either external beam boost to the recurrent site in 18 patients (34%) or intracavitary irradiation in 24 patients (45.3%). Total dose of radiation ranged from 46.8 Gy to 111 Gy (median 70.2 Gy). Follow up period ranged from 2 to 153 months with a median of 35 months. Overall response rate was 66% (35/53). Among them, six patients (17.1%) relapsed between 7 months and 116 months after radiation therapy (mean 47.7 months). Therefore overall recurrence rate was 45.3%. Overall five-year actuarial survival rate was 78.9% and distant failure rate was 10% (5/50). The significant prognostic factors affecting survival rate were interval between primary surgery and tumor recurrence (p=0.0055), recurrent tumor size (p=0.0039), and initial response to radiation therapy (p=0.0428). Complications were observed in 10 (20%) patients, which included mild to moderate lower gastrointestinal, genitourinary, or skin manifestations. One patient died of pulmonary embolism just after intracavitary irradiation. Radiation therapy is the effective treatment for the patients with locally recurrent cervical cancer after curative surgery. These results suggest that interval between primary surgery and tumor recurrence, recurrent tumor size, and initial response to radiation therapy were significant prognostic factors for recurrent cervical cancer.

Ryu, Mi Ryeong; Kay, Chul Seung; Kang, Ki Moon; Kim, Yeon Shil; Chung, Su Mi; Namkoong, Sung Eun; Yoon, Sei Chul [College of Medicine, The Catholic Univ of Korea., Seoul (Korea, Republic of)

1999-06-01

22

Results of Radiation Therapy in Stage III Uterine Cervical Cancer  

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Purpose : The aim of this study is to analyze the survival rate, treatment failure and complication of radiation therapy alone in stage III uterine cervical cancer. Materials and Methods : From January 1980 through December 1985, 227 patients with stage II uterine cervical cancer treated with radiation therapy at Kosin Medical Center were retrospectively studied. Among 227 patients, 72 patients(31.7%) were stage IIIa, and 155 patients(68.3%) were stage IIIb according to FIGO classification. Age distribution was 32-71 years(median: 62 years). Sixty nine patients(95.8%) in stage IIIa and 150 patients(96.8%) in stage IIIb were squamous cell carcinoma. Pelvic lymph node metastasis at initial diagnosis was 8 patients (11.1%) in stage IIIa and 29 patients(18.7%) in stage IIIb. Among 72 patients with stage IIIa, 36 patients(50%) were treated with external radiation therapy alone by conventional technique (180-200 cGy/fr). And 36 patients(50%) were treated with external radiation therapy with intracavitary radiotherapy(ICR) with Cs137 sources, and among 155 patients with stage IIIb, 80 patients(51.6%) were treated with external radiation therapy alone and 75 patients(48.4%) were treated with external radiation therapy with ICR. Total radiation doses of stage IIIa and IIIb were 65-105 Gy(median : 78.5 Gy) and 65-125.5 Gy (median :83.5 Gy). Survival rate was calculated by life-table method. Results : Complete response rates were 58.3% (42 patients) in state IIIa and 56.1%(87 pa42 patients) in state IIIa and 56.1%(87 patients) in stage Iiib. Overall 5 year survival rates were 57% in stage IIIa and 40% in stage IIIb. Five year survival rates by radiation technique in stage IIIa and IIIb were 64%, 40% in group treated in combination of external radiation and ICR, and 50%, 40% in the group of external radiation therapy alone(P=NS). Five year survival rates by response of radiation therapy in stage IIIa and IIIb were 90%, 66% in responder group, and 10%, 7% in non-responder group (P<0.01). There were statistically no significances of 5 year survival rate by total radiation doses and external radiation doses (40 Gy vs 50 Gy) of whole or true pelvis in stage IIIa and IIIb(P=NS). Treatment failures rates were 40.3%(29 patients) in stage IIIa and 57.4%(89 patients) in stage IIIb, 17 patients (23.6%) in stage IIIa and 46 patients (29.7%) in stage IIIb experienced complications. Total radiation doses more than 85 Gy produced serious complication in both stage IIIa(50%) and Iib(50%), Serious complication rates were higher in group received external radiation doses of 50 Gy than 40 Gy to whole or true pelvis in stage IIIa and IIIb. Serious rectal complication developed in rectal doses more than 65 Gy, and serious bladder complication developed in bladder doses more than 75 Gy. Major cause of death was cachexia due to locoregional failure in both stage IIIa(34.7%) and IIIb(43.9%). Conclusion : From this study, we found that external radiation therapy with ICR was found to have a tendency to be superior to external radiation therapy alone in survival rate, local control rate and complication rate but not different in statistics, and external radiation doses of 50 Gy than 40 Gy tho whole or true pelvis produced serious rectal and bladder complications in stage III uterine cervical cancer

23

Results of Radiation Therapy in Stage III Uterine Cervical Cancer  

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Purpose : The aim of this study is to analyze the survival rate, treatment failure and complication of radiation therapy alone in stage III uterine cervical cancer. Materials and Methods : From January 1980 through December 1985, 227 patients with stage II uterine cervical cancer treated with radiation therapy at Kosin Medical Center were retrospectively studied. Among 227 patients, 72 patients(31.7%) were stage IIIa, and 155 patients(68.3%) were stage IIIb according to FIGO classification. Age distribution was 32-71 years(median: 62 years). Sixty nine patients(95.8%) in stage IIIa and 150 patients(96.8%) in stage IIIb were squamous cell carcinoma. Pelvic lymph node metastasis at initial diagnosis was 8 patients (11.1%) in stage IIIa and 29 patients(18.7%) in stage IIIb. Among 72 patients with stage IIIa, 36 patients(50%) were treated with external radiation therapy alone by conventional technique (180-200 cGy/fr). And 36 patients(50%) were treated with external radiation therapy with intracavitary radiotherapy(ICR) with Cs137 sources, and among 155 patients with stage IIIb, 80 patients(51.6%) were treated with external radiation therapy alone and 75 patients(48.4%) were treated with external radiation therapy with ICR. Total radiation doses of stage IIIa and IIIb were 65-105 Gy(median : 78.5 Gy) and 65-125.5 Gy (median :83.5 Gy). Survival rate was calculated by life-table method. Results : Complete response rates were 58.3% (42 patients) in state IIIa and 56.1%(87 patients) in stage Iiib. Overall 5 year survival rates were 57% in stage IIIa and 40% in stage IIIb. Five year survival rates by radiation technique in stage IIIa and IIIb were 64%, 40% in group treated in combination of external radiation and ICR, and 50%, 40% in the group of external radiation therapy alone(P=NS). Five year survival rates by response of radiation therapy in stage IIIa and IIIb were 90%, 66% in responder group, and 10%, 7% in non-responder group (P<0.01). There were statistically no significances of 5 year survival rate by total radiation doses and external radiation doses (40 Gy vs 50 Gy) of whole or true pelvis in stage IIIa and IIIb(P=NS). Treatment failures rates were 40.3%(29 patients) in stage IIIa and 57.4%(89 patients) in stage IIIb, 17 patients (23.6%) in stage IIIa and 46 patients (29.7%) in stage IIIb experienced complications. Total radiation doses more than 85 Gy produced serious complication in both stage IIIa(50%) and Iib(50%), Serious complication rates were higher in group received external radiation doses of 50 Gy than 40 Gy to whole or true pelvis in stage IIIa and IIIb. Serious rectal complication developed in rectal doses more than 65 Gy, and serious bladder complication developed in bladder doses more than 75 Gy. Major cause of death was cachexia due to locoregional failure in both stage IIIa(34.7%) and IIIb(43.9%). Conclusion : From this study, we found that external radiation therapy with ICR was found to have a tendency to be superior to external radiation therapy alone in survival rate, local control rate and complication rate but not different in statistics, and external radiation doses of 50 Gy than 40 Gy tho whole or true pelvis produced serious rectal and bladder complications in stage III uterine cervical cancer.

Moon, Chang Woo; Shin, Byung Chul; Yum, Ha Yong; Jeung, Tae Sig; Yoo, Myung Jin [Kosin University College of Medicine, Seoul (Korea, Republic of)

1995-09-15

24

Telomerase activation and human papillomavirus infection in invasive uterine cervical carcinoma in a set of Malaysian patients  

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Aim: Telomerase activity was studied in invasive uterine cervical carcinoma to assess whether it was activated during cervical malignant transformation and to look for a possible association with human papillomavirus (HPV) infection in a set of Malaysian patients.

Cheah, P. L.; Looi, L. M.; Ng, M. H.; Sivanesaratnam, V.

2002-01-01

25

Postirradiation sarcoma (malignant fibrous histiocytoma) following uterine cervical cancer  

International Nuclear Information System (INIS)

A case of postirradiation sarcoma, a malignant fibrous histiocytoma, is described. The tumor occurred in the radiation field (the buttock) 8 years after radiation therapy for keratinizing squamous cell carcinoma of the uterine cervix. The 68-year-old female patient with the inital diagnosis of cervical cancer was treated with pelvic irradiation in 1973. She did well after that with no evidence of disease until 1981 when she developed an enlarging mass in the right buttock within the field of the previous radiation therapy. Microscopically, the tumor at biopsy was composed of pleomorphic histiocyte-like cells, spindle-sphaped cells arranged in a storiform pattern and multinucleated giant cells with bizarre nuclei. Cytodiagnostically, two types of cells, fibroblast-like cells ane histiocyte-like cells, were found. And some cells were considered to be transitional forms, intermediate between fibroblast and histiocytes. Multinucleated pleomorphic giant cells were sometimes seen. Ultrastructurally, the same types of cells were confirmed. These cells contained large numbers of rough endoplasmic reticula with dilated lumens, vacuoles, lysosomal structures, and lipid droplets. (author)

26

A study on prognostic factors of uterine cervical cancer  

International Nuclear Information System (INIS)

Prognostic factors of cancer of the cervix were studied in 286 cases treated by radiotherapy. The four items started below relating to morphological characteristics and found to be comparatively easy to determine clinically were selected as prognostic factors. The factors are (1) clinical stage, (2) morphology of the uterine cervix, (3) histological type of cancer and (4) radiosensitivity. Each prognostic factor and prognosis indicated in every case by chi-square test (X2 test) a risk rate lower than 0.1%, a significant difference. Furthermore, every prognostic factor was given points according to their grade, and the total points were expressed as a prognostic index. The prognostic index was classified into the mild zone (from 1 to 8 points), the moderate zone (from 9 to 10 points), and the severe zone (from 11 to 18 points), and the five year survival rate of each zone was observed to be 91.5%, 56.1% and 18.9% respectively. Thus, at a risk of less than 0.1%, a significant difference was observed. By setting up the prognostic index, it was possible to estimate the prognosis of every case of cervical carcinoma, which to date had been nearly impossible to estimate by each prognostic factor alone. (author)

27

Conservative treatment of a cervical twin pregnancy with uterine artery embolization.  

Science.gov (United States)

Cervical pregnancy is a rare form of ectopic pregnancy. Its treatment has been described by different authors. We report our successful experience of a cervical twin pregnancy that was diagnosed by transabdominal and transvaginal ultrasound and confirmed by magnetic resonance imaging. To preserve fertility, our patient was treated by a bilateral hyperselective uterine artery embolization followed by dilatation and curettage of the cervical canal without ancillary procedures for cervical hemostasis. Arterial embolization by a resorbable agent reduces arterial circulation by providing a temporary occlusion of the vessels in order to decrease the risk of massive hemorrhage. PMID:19838985

Ben Farhat, Leila; Ben Salah, Yosr; Askri, Anis; Dali, Nadida; Hendaoui, Lotfi

2010-09-01

28

High-dose-rate brachytherapy in uterine cervical carcinoma  

International Nuclear Information System (INIS)

Purpose: High-dose-rate (HDR) brachytherapy is in wide use for curative treatment of cervical cancer. The American Brachytherapy Society has recommended that the individual fraction size be <7.5 Gy and the range of fractions should be four to eight; however, many fractionation schedules, varying from institution to institution, are in use. We use 9 Gy/fraction of HDR in two to five fractions in patients with carcinoma of the uterine cervix. We found that our results and toxicity were comparable to those reported in the literature and hereby present our experience with this fractionation schedule. Methods and Materials: A total of 121 patients with Stage I-III carcinoma of the uterine cervix were treated with HDR brachytherapy between 1996 and 2000. The total number of patients analyzed was 113. The median patient age was 53 years, and the histopathologic type was squamous cell carcinoma in 93% of patients. The patients were subdivided into Groups 1 and 2. In Group 1, 18 patients with Stage Ib-IIb disease, tumor size <4 cm, and preserved cervical anatomy underwent simultaneous external beam radiotherapy to the pelvis to a dose of 40 Gy in 20 fractions within 4 weeks with central shielding and HDR brachytherapy of 9 Gy/fraction, given weekly, and interdigitated with external beam radiotherapy. The 95 patients in Group 2, who had Stage IIb-IIIb disease underwent external beam radiotherapy to the pelvis to a dose of 46 Gy in 23 fractions within 4.5 weeks followed by two sactions within 4.5 weeks followed by two sessions of HDR intracavitary brachytherapy of 9 Gy each given 1 week apart. The follow-up range was 3-7 years (median, 36.4 months). Late toxicity was graded according to the Radiation Therapy Oncology Group criteria. Results: The 5-year actuarial local control and disease-free survival rate was 74.5% and 62.0%, respectively. The actuarial local control rate at 5 years was 100% for Stage I, 80% for Stage II, and 67.2% for Stage III patients. The 5-year actuarial disease-free survival rate was 88.8% for Stage I, 76.52% for Stage II, and 50.4% for Stage III patients. Local failure occurred in 2 (11.1%) of the 18 Group 1 patients and in 20 (21.0%) of the 95 Group 2 patients. Distant failure occurred in none of the Group 1 patients and in 8 (8.4%) of the 95 Group 2 patients. None of the patients developed Grade 3 rectal toxicity. Grade 3 bladder toxicity was observed in 2 patients. The actuarial risk of Grade 3 or worse late toxicity was 3.31%. Conclusion: The results of our study indicate that HDR brachytherapy at 9 Gy/fraction is both safe and effective in the management of carcinoma of the cervix, with good local control and a minimum of normal tissue toxicity

29

Electron microscopic study on radiosensitivity of uterine cervical cancer  

International Nuclear Information System (INIS)

The effects of 1000 R of tele-cobalt upon the changes in the primary lesions of uterine cervical cancer with time were studied with an electron microscope. In addition, twenty cases which were proven to have cancer tissues (10 cases of IInd stage of cancer, 8 cases of IIIrd stage of cancer and 2 cases of IVth stage of cancer) were studied. Four cases were favourably sensitive, 7 cases moderately sensitive and 9 cases unfavourably sensitive to radiation. In favourably radio-sensitive cases, the changes in the cancer cells first appeared in the nucleus. There were other changes such as local clumping of chromatin and, specifically, vacuolization of the nucleus. The changes in the endoplasmic reticulum appeared somewhat late. In addition, the disturbance of mitochondria and the decrease or disappearance of ribosomes were specifically due to radiation injury. From the point of view of changes with time, Golgi's apparatus was enlarged and the membrane of the endoplasmic reticulum was degenerated at the 1st day. At the 3rd day, vacuolization of the nucleus appeared, the nuclear corpuscles were increased, the nucleoplasm became thin, and mitochondria was enlarged and degenerated. At the 5th day, the nuclear membrane disappeared, the nucleus was destroyed, large vacuolization of the endoplasmic reticulum was seen, free ribosomes were decreased, and changes around the endoplasmic reticulum were observed. At the 7th day, collagen around the endoplasmic reticulum appeared. In fa the endoplasmic reticulum appeared. In favourably radiosensitive cases, individual tumor cells showed the same degeneration, which fairly corresponded to that evaluated by the histological observation. The disturbance of the cells was caused by radiation, so-called ''burning'' of the cells. Radiation protection of the cells against burning was considered in terms of their radiosensitivity. (K. SERIZAWA)

30

Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology  

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To design clear guidelines for the staging and follow-up of patients with uterine cervical cancer, and to provide the radiologist with a framework for use in multidisciplinary conferences. Methods: Guidelines for uterine cervical cancer staging and follow-up were defined by the female imaging subcommittee of the ESUR (European Society of Urogenital Radiology) based on the expert consensus of imaging protocols of 11 leading institutions and a critical review of the literature. The results indicated that high field Magnetic Resonance Imaging (MRI) should include at least two T2-weighted sequences in sagittal, axial oblique or coronal oblique orientation (short and long axis of the uterine cervix) of the pelvic content. Axial T1-weighted sequence is useful to detect suspicious pelvic and abdominal lymph nodes, and images from symphysis to the left renal vein are required. The intravenous administration of Gadolinium-chelates is optional but is often required for small lesions (<2 cm) and for follow-up after treatment. Diffusion-weighted sequences are optional but are recommended to help evaluate lymph nodes and to detect a residual lesion after chemoradiotherapy. Expert consensus and literature review lead to an optimized MRI protocol to stage uterine cervical cancer. MRI is the imaging modality of choice for preoperative staging and follow-up in patients with uterine cervical cancer. (orig.)

Balleyguier, Corinne [Radiology Department, Institut Gustave Roussy, Villejuif (France); Sala, E. [Radiology Department, Addenbrooke' s Hospital, Cambridge (United Kingdom); Cunha, T. da [Radiology Department, Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Lisbon (Portugal); Bergman, A. [Department of Radiology, Uppsala University Hospital (Sweden); Brkljacic, B. [Department of Diagnostic and Interventional Radiology, University Hospital ' ' Dubrava' ' , Zagreb (Croatia); Danza, F. [Dipartimento di Bioimmaginie Scienze Radiologiche, Universita Cattolica del S. Cuore, Rome (Italy); Forstner, R. [Zentralroentgeninstitut, Landeskliniken Salzburg, Salzburg (Austria); Hamm, B. [Department of Radiology, Charite Humboldt Universitaet, Berlin (Germany); Kubik-Huch, R. [Institut Radiologie, Kantonsspital Baden, Baden (Switzerland); Lopez, C.; Manfredi, R. [Department of Radiology, ' ' A. Gemelli' ' University Hospital, Rome (Italy); McHugo, J. [Department of Radiology, Birmingham Women' s Hospital, Birmingham (United Kingdom); Oleaga, L. [Radiology Department, Hospital Clinic, Barcelona (Spain); Togashi, K. [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Graduate School of Medicine, Kyoto (Japan); Kinkel, K. [Institut de Radiologie, Clinique des Grangettes, Geneva (Switzerland)

2011-05-15

31

Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology  

International Nuclear Information System (INIS)

To design clear guidelines for the staging and follow-up of patients with uterine cervical cancer, and to provide the radiologist with a framework for use in multidisciplinary conferences. Methods: Guidelines for uterine cervical cancer staging and follow-up were defined by the female imaging subcommittee of the ESUR (European Society of Urogenital Radiology) based on the expert consensus of imaging protocols of 11 leading institutions and a critical review of the literature. The results indicated that high field Magnetic Resonance Imaging (MRI) should include at least two T2-weighted sequences in sagittal, axial oblique or coronal oblique orientation (short and long axis of the uterine cervix) of the pelvic content. Axial T1-weighted sequence is useful to detect suspicious pelvic and abdominal lymph nodes, and images from symphysis to the left renal vein are required. The intravenous administration of Gadolinium-chelates is optional but is often required for small lesions (<2 cm) and for follow-up after treatment. Diffusion-weighted sequences are optional but are recommended to help evaluate lymph nodes and to detect a residual lesion after chemoradiotherapy. Expert consensus and literature review lead to an optimized MRI protocol to stage uterine cervical cancer. MRI is the imaging modality of choice for preoperative staging and follow-up in patients with uterine cervical cancer. (orig.)

32

Super-selective uterine artery chemoembolization for the treatment of cervical cancer: its clinical value  

International Nuclear Information System (INIS)

Objective: To evaluate super-selective uterine arterial chemoembolization therapy in the treatment of cervical cancer. Methods: Bilateral uterine arterial infusion with DDP, EADM or THP, MMC and 5-Fu was performed in 56 patients with pathologically-proved cervical cancer, which was followed by embolization of uterine arteries with iodine emulsion and Gelfoam particles. Radical hysterectomy was performed in 6 patients after interventional treatment. Results: Embolization of bilateral uterine arteries were successfully carried out in all cases. The angiography conducted during the procedure revealed markedly dilated uterine arteries, spiral tumor-feeding arteries and obvious tumor staining. The total effective rate was up to 94.6%. Six patients received radical hysterectomy 2 weeks after arterial chemoembolization, and the blood loss during the operation was much less than usual and the surgery procedure took shorter time. Ovarian necrosis was found in 1 case. The main adverse effects included leukocytopenia, nausea, vomiting and abdominal pain. Conclusion: Super-selective uterine arterial chemoembolization is a safe and effective supplementary therapy for cervical carcinoma with fewer complications. (authors)

33

The comparison of radiosensitivity between uterine cervical squamous carcinoma and adenocarcinoma  

International Nuclear Information System (INIS)

Objective: To compare the radiosensitivity of uterine cervical squamous carcinoma and adenocarcinoma. Methods: The shrinkage of tumor and the radiation-induced damage were compared between cervical squamous carcinoma and adenocarcinoma after twice afterloading radiotherapy. Proliferating cell nuclear antigen index (PI), detected immuno-histo-chemically, was compared before and after radiotherapy between the two tumors. Results: Patients of squamous carcinoma with tumor shrinkage 50% or more accounted for 70% (21/30) and patients of adenocarcinoma accounted for 27% (4/15), which was statistically significant (P0.05). Conclusions: The radiosensitivity of cervical squamous carcinoma is higher than that of adenocarcinoma. The decrease of PI after radiotherapy may be a biological basis of radiosensitivity for uterine cervical squamous carcinoma

34

Obstetric performance of a patient with multiple uterine and cervical fibroids and expectant management of retained placenta.  

OpenAIRE

ABSTRACT The aim of this case report is to describe the obstetric performance of a patient with multiple uterine and supravaginal cervical fibroids. A 36-year-old, gravida 3 para 0+2 with multiple uterine and cervical fibroids presented with inevitable abortion at 17 weeks gestation. She had a spontaneous rupture of membranes followed by expulsion of fetus as breech with entrapment of aftercoming head by a cervical fibroid. Oxytocin infusion and digital traction were able to deliver the fe...

Begum, Mahfuza H.; Mustafa, Mohamed S.

2002-01-01

35

Ex-vivo ultrasound attenuation coefficient for human cervical and uterine tissue from 5 – 10 MHz  

OpenAIRE

Attenuation estimation and imaging in the cervix has been utilized to evaluate the onset of cervical ripening during pregnancy. This feature has also been utilized for the acoustic characterization of leiomyomas and myometrial tissue. In this paper, we present direct narrowband substitution measurement values of the variation in the ultrasonic attenuation coefficient in ex vivo human uterine and cervical tissue, in the 5–10 MHz frequency range. At 5 MHz, the attenuation coefficient values a...

Kiss, Miklos Z.; Varghese, Tomy; Kliewer, M. A.

2010-01-01

36

Role of FDG-PET in initial workup of uterine cervical cancer  

International Nuclear Information System (INIS)

FDG-PET is widely utilized in gynecologic malignancies. In uterine cervical cancer, although CT, MRI and PET are not included for the most widely used FIGO staging, they may provide useful information additional to clinical stage. We thus investigated the role of FDG-PET in the initial workup of uterine cervical cancer. A total of 85 newly diagnosed uterine cervical cancer patients were included (mean age 50±12yr). Patients previously treated for the cancer were excluded, but conization was an exception. Attenuation corrected whole body PET was interpreted by two nuclear medicine physicians. Suspicious malignant lesions on PET were confirmed by surgical biopsy or other imaging studies. Main tumor masses were detected by FDG-PET in 79 patients (93%). PET detected 15 iliac and 8 paraaortic lymph nodes with increased uptake that was suggested to be metastatic based on other modalities. Among patients who had surgical confirmation of lymph node status, 36 of 40 (90%) patients without lymph node metastasis had concordant PET findings, while PET correctly detected 5 of 16(31%) lymph node metastases. In 8/85 patients (9%), FDG-PET detected distant metastastic lesions which had not been detected by other modalities. Of these patients, treatment modality was changed in 1 and the radiation field was modified in 3 patients. FDG-PET is useful for detecting unidentified metastastic lesions in the initial workup of uterine cervical cancer, and may thus aid in decisions for optionaand may thus aid in decisions for optional therapeutic strategies

37

A randomised comparison of two brachytherapy devices for the treatment of uterine cervical carcinoma  

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Two brachytherapy applicators commonly used in the treatment of uterine cervical carcinoma, the Henschke shielded and Fletcher-Suit-Declos, were randomly and prospectively compared in vivo in 20 patients. Based on two-dimensional planning and the ICRU-38 bladder and rectal reference points, an advantage for the shielded Henschke applicator was demonstrated

38

Primary cervical and uterine corpus lymphoma; a case report and literature review.  

Czech Academy of Sciences Publication Activity Database

Ro?. 6, ?. 4 (2013), s. 298-306. ISSN 1940-5901 R&D Projects: GA ?R GAP502/12/2409 Institutional support: RVO:60077344 Keywords : Non-Hodgkin's lymphoma * extra-nodal lymphoma * uterine/cervical lymphoma Subject RIV: EC - Immunology Impact factor: 1.422, year: 2013

Anagnostopoulos, A.; Mouzakiti, N.; Ruthven, S.; Herod, J.; Kotsyfakis, Michalis

2013-01-01

39

Metastatic Breast Cancer to the Uterine Cervix Mimicking a Giant Cervical Leiomyoma  

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Full Text Available Metastasis to the uterine cervix is a complication of breast cancer that is not commonly known. Detection of cervical metastasis before the diagnosis of the primary tumor is even rarer. The present report describes a case of a 52-year-old woman who had a large cervical tumor appearing as a leiomyoma. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Histopathological examination of the cervical tumor showed patterns characteristic of invasive lobular carcinoma of the breast, leading to the discovery of the primary in the left breast. She subsequently underwent mastectomy, hormone therapy and chemotherapy, and is alive at 7-year follow-up.

MAI HORIKAWA

2012-08-01

40

Value of intramuscular methotrexate and bilateral uterine artery embolization for treating cervical ectopic pregnancy  

International Nuclear Information System (INIS)

Objective: To assess the clinical value of bilateral uterine artery chemotherapy embolization (UACE) for cervical ectopic pregnancy analyzed. Methods: Clinical records of 40 patients with cervical ectopic pregnancy treated using UACE were retrospectively analyzed. Results: 8 patients with severe active vaginal bleeding after curettage were treated urgently with UACE. The remaining 32 patients were treated with UACE combined with sequential ultrasound-guided curettage. Active vaginal bleeding was stopped after UACE. There was no recurrent hemorrhage with the sequential ultrasound-guided curettage procedure. The ?-HCG levels of all patients were normalized after 1 month. Conclusion: Bilateral uterine artery chemotherapy embolization is valuable as emergency treatment for patients with severe vaginal bleeding from cervical ectopic pregnancy. UACE combined with sequential ultrasound-guided curettage may be more effective. (authors)

41

Plasma cholinesterase activity in patients with uterine cervical cancer during radiotherapy.  

Science.gov (United States)

The objectives of this study were to investigate: 1) the activity of pseudocholinesterase (PChE) in patients with uterine cervical cancer in different stages (uterine cervical carcinoma in stages II b and III and recurrent cervical carcinoma in stages III and IV a,b) and to compare it to the enzyme activity in patients with benign tumour of the uterus, and 2) the effects of radiotherapy on enzyme activity in those patients with uterine cervical carcinoma for which the chosen treatment was radical radiotherapy. Thirty patients with uterine cervical carcinoma in stages II b and III (Group A), sixteen patients with recurrent cervical carcinoma in stages III and IV a,b (Group B) and thirty-eight patients with benign tumours of the uterus (control, Group C) were evaluated and their PChE activity was determined prior to any treatment (pre-therapy enzyme activity). All eighty-four patients were free of any liver disease. The results have shown that the patients of Group A had the pre-therapy PChE activity practically identical to those in group C, but patients of Group B had significantly lower values of PChE with respect to enzyme activities of Groups A and C (p < 0.001). That is to say, PChE activity was influenced by the extent to which the malignancy had spread. Radical radiotherapy (up to 8 weeks in doses higher than 50 Gy into point A; average 80 Gy) which was the chosen treatment only for patients from group A did not cause a significant inhibition of PChE activity in any patients in comparison with their control values. With regard to the role of PChE in hydrolysis of succinylcholine, our results about the influence of the malignant disease and the radiotherapy on PChE activity are clinically significant. PMID:11216405

Bradamante, V; Smigovec, E; Bukovi?, D; Geber, J; Matani?, D

2000-12-01

42

Amniotic fluid embolism induces uterine anaphylaxis and atony following cervical laceration.  

Science.gov (United States)

Amniotic fluid embolism (AFE) is a rare, high-risk obstetric complication primarily found in the lungs and potentially related to anaphylaxis. Tryptase release from the mast cell reflects anaphylaxis. Case report and findings: A female, aged over 40 years, presented with uterine atony and lethal hemorrhage after induced vaginal labor. Cervical laceration was accompanied by severe hemorrhage. Stromal edema and myometrial swelling were consistent with uterine atony. Alcian blue staining and zinc coproporphyrin immunostaining disclosed AFE, which was more prominent in the uterus than in the lungs. Tryptase immunostaining was diffuse and prominent around the activated mast cells (halos) in the uterus, including the cervix. Similar distribution of findings on the AFE markers, tryptase halos, complement receptor C5aR, and atony in the uterus suggested the causality of AFE to anaphylaxis, complement activation and atony. It is probable that disseminated intravascular coagulation (DIC), induced by AFE, uterine atony and cervical laceration, caused the lethal hemorrhage. It is likely that AFE, in association with cervical laceration, induces uterine anaphylaxis, complement activation, atony, DIC and lethal hemorrhage. PMID:24925137

Tamura, Naoaki; Nagai, Hisashi; Maeda, Hidyuki; Kuroda, Ryo-hei; Nakajima, Makoto; Igarashi, Atsuko; Kanayama, Naohiro; Yoshida, Ken-ichi

2014-01-01

43

Superselective uterine artery chemoembolization for the treatment of cervical cancer: a clinical analysis of 33 cases  

International Nuclear Information System (INIS)

Objective: To discuss the clinical therapeutic effect and side reaction of superselective uterine arterial chemoembolization therapy for the treatment of cervical cancer. Methods: Bilateral uterine arterial chemoembolization was performed in 33 patients with pathologically-proved cervical cancer. The infusion drugs included DDP or L-OHP, EADM, MMC and 5-Fu. The Gelfoam particle was employed as embolic agent. The therapeutic effect evaluated by observing the improvement of clinical symptoms and the volume reduction of the tumor. Results: Of the total 33 patients with pathologically-confirmed cervical cancer, squamous cell carcinoma was seen in 29 and adenocarcinoma in 4. Based on FIGO classification (established by Federation International of Gynecology and Obstetrics), 6, 23 and 4 patients were classified in stage ?, ? and ? respectively. The angiography conducted during the procedure showed that the uterine arteries were markedly dilated, and spiral tumor-feeding arteries as well as tumor stain were also observed. Technical success together with perfect chemoembolization was achieved for 57 uterine arteries in 33 patients. Among the 33 patients, the interventional treatment was carried out three times in 2, two times in 2 and single time in 29. One week after the initial interventional procedure the remission rate of the clinical symptoms was 96% for squamous cell carcinoma and 100% for adenocarcinoma. One month after the treatment, the mean tumor volume was decreased by 30%, the tumor volume reduction for squamous cell carcinoma was 27.6% and was 50.0% for adenocarcinoma. Surgical resection after interventional therapy was carried out in 21 cases and additional radiotherapy after surgery or interventional procedure was adopted in 11 cases. The main adverse reactions after interventional procedure included fever, leucocytopenia, nausea, vomiting, abdominal pain, etc. Conclusion: Superselective uterine arterial chemoembolization is one of effective supplementary measures for the comprehensive treatment of cervical carcinoma. (authors)

44

Prediction of prognosis using pretreatment FDG PET in uterine cervical carcinoma  

International Nuclear Information System (INIS)

In uterine cervical cancer, it is clinically important to predict prognosis on initial staging. We investigated whether abnormally increased FDG uptake of lymph nodes and peak SUV of primary tumor on initial FDG PET can predict prognosis after treatment in cervical patients. Subjects were 74 newly diagnosed cervical cancer patients (50±12yr). Whole body PET was performed after an injection of F-18 FDG. Peak SUV was measured in the primary cervical tumor. Images were interpreted by two nuclear medicine physicians. Follow-up for the disease-free survival was done in all patients. Survival analysis was done by using the Kaplan-Meier method, and a Logrank test was used to compare survival. Cox regression analysis was followed to find independent predictive factors. Recurrence occurred in 13 patients. In univariate analysis, advanced FIGO stage, large size of primary tumor, positive lymph node on MRI of CT, and positive lymph node on PET were significant prognostic factors to predict recurrence. Peak SUV and cell type of tumor failed to show any significant correlation with disease-free survival. In multivariate analysis, positive lymph node on PET (Exp(?)=6.416, p=0.002) and on CT or MRI (Exp(?)=5.711, p=0.026) were independent prognostic factors for predicting recurrence. In uterine cervical cancer, lymph node metastasis of pretreatment FDG PET is the best independent prognostic factor for predicting recurrence. But, peak SUV was not significant prognostic factor not significant prognostic factor

45

Cerebellous metastases in patients with uterine cervical cancer. Two cases reports and review of the literature.  

Science.gov (United States)

Brain metastases from cervical cancer are extremely rare. We report on two patients who developed cerebellous metastases following uterine cervical cancer. The interval between diagnosis of the primary cancer and diagnosis of brain metastasis was 8 months. The main complaint was symptoms of increased intracranial pressure and cerebellous syndrome. Surgical excision of the brain lesion followed by radiation therapy was performed in the first case. The second patient received palliative radiation therapy. The first patient died 8 months after diagnosis. The second patient is alive 2 months after diagnosis. PMID:14522353

Omari-Alaoui, H El; Gaye, P M; Kebdani, T; El Ghazi, E; Benjaafar, N; Mansouri, A; Errihani, H; Kettani, F; El Ouahabi, A; El Gueddari, B K

2003-10-01

46

Cerebellar metastases in patients with uterine cervical cancer. Two cases reports and review of the literature  

International Nuclear Information System (INIS)

Brain metastases from cervical cancer are extremely rare. We report on two patients who developed cerebellar metastases following uterine cervical cancer. The interval between diagnosis of the primary cancer and diagnosis of brain metastasis was 8 months. The main complaint was symptoms of increased intracranial pressure and cerebellar syndrome. Surgical excision of the brain lesion followed by radiation therapy was performed in the first case. The second patient received palliative radiation therapy. The first patient died 8 months after diagnosis. The second patient is alive 2 months after diagnosis. (authors)

47

Actions of progestins for the inhibition of cervical ripening and uterine contractions to prevent preterm birth  

OpenAIRE

The importance of progesterone (P4) for maintenance of pregnancy, its role in cervical ripening and uterine contractions is at least partly established and therefore, not surprisingly, the basis for the concept to use P4 as a treatment for preterm birth. Due to the complexity of the condition of preterm birth there are still questions concerning the optimal population that might benefit, timing of treatment, dosage, vehicle and route of administration. Recently vaginal P4 and intramuscular 17...

Kuon, R. -j; Garfield, R. E.

2012-01-01

48

Hysterectomy prevalence and adjusted cervical and uterine cancer rates in England and Wales.  

OpenAIRE

OBJECTIVE: To present recent trends in cervical and uterine cancer adjusted for true population at risk, using accurate estimates of the prevalence of hysterectomy where the cervix has been removed or not. To describe trends and projections of hysterectomy incidence and prevalence with and without cervix removal. DESIGN: Collation of available NHS and private sector information. SETTING: England and Wales. SAMPLE: NHS operations from Hospital Inpatient Enquiry, Hospital Episode Statistics and...

Redburn, Jc; Murphy, Mf

2001-01-01

49

Expression of anionic glutathione S transferase (GST pi) gene in carcinomas of the uterine cervix and in normal cervices.  

OpenAIRE

The aim of the present study was to analyse in invasive carcinomas of the uterine cervix, the anionic glutathione S transferase (GST pi) gene, possibly implicated in the drug resistance of human cancers. Total RNA preparations obtained from invasive cervical cancers (106 specimens), carcinomas in situ (CIS) (three specimens) and normal cervical epitheliums (24 specimens) were analysed by Northern and slot blot hybridisation. A 0.7 kb GST pi transcript band was detected in all the cervical spe...

Riou, G.; Barrois, M.; Zhou, D.

1991-01-01

50

The Prevalence and pattern of HPV-16 immunostaining in uterine cervical carcinomas in Ethiopian women: a pilot study  

OpenAIRE

INTRODUCTION: Cancer of the cervix uteri is the second most common cancer among women worldwide. The association of human papillomavirus (HPV) infection with cervical carcinogenesis is well documented. This is a pilot study aiming to studying the prevalence and the pattern of Human Papilloma Virus Type 16 (HPV16) by immunostaining in the tissues of cervical carcinomas of Ethiopian women. METHODS: 20 specimens of uterine cervical carcinomas were studied histopathologically and immunohistochemi...

Rashed, Mona M.; Alemayehu Bekele

2011-01-01

51

Therapeutic effect of intra-arterial chemotherapy with DDP and 5-FU via bilateral uterine arteries for advanced uterine cervical cancer  

International Nuclear Information System (INIS)

Objective: To evaluate the therapeutic effect of intra-arterial chemotherapy with Ddp and 5-Fu via bilateral uterine arteries for advanced uterine cervical cancer. Methods: During the period of Jan. 2006-Jan. 2009, initial intra-arterial chemotherapy by using a combination of Ddp and 5-Fu via bilateral uterine arteries was performed in 72 patients (mean age 42.9 years) with advanced uterine cervical caner. Of 72 patients, stage I b2 cervical cancer was confirmed in 28, stage II a in 12 and stage II b in 32. Pathologically, cervical squamous cell carcinoma was seen in 56 and cervical adenocarcinoma in 16 patients. Ultrasonography and physical examination were conducted both before and after intra-arterial chemotherapy. The therapeutic results,complications,the surgical resection rate and the pathologic findings were observed and statistically analyzed. Results: Fifty-four patients received one treatment course and 18 patients received two treatment courses. The over all response rate was 77.8%. The response rates of patients with I b2, II a and II b cervical cancer were 92.9%, 83.3% and 62.5% respectively, the difference between three groups was statistically significant (P < 0.05). And the response rates of patients with squamous cell carcinoma and adenocarcinoma were 85.7% and 50.0% respectively, the difference between the two was statistically significant (P < 0.05). The most common side-effects included gastrointestinal symptoms and bone marrow suppression. Thirty-ptoms and bone marrow suppression. Thirty-four patients received radical hysterectomy,among them, 22 (78.6%) had stage I b2, 8 (66.7%) had stage II a and 4 (12.5%) had stage II b cervical cancer (P < 0.05). Pathologic exam found no vaginal invasion and ovarian metastasis in all 34 patients. The occurrence of metastasis to lymph nodes and para uterine infiltration were 17.6% and 11.8% respectively. Conclusion: Intra-arterial chemotherapy with a combination of DDP and 5-Fu via bilateral uterine arteries can safely and effectively reduce the tumor volume of advanced cervical cancer, suppress the lymph node metastasis and parametrial infiltration, which is very helpful for creating favorable condition required by the surgery and for reducing the manipulative difficulties of radical hysterectomy. Intra-arterial chemotherapy has better effect on stage Ib2 cervical cancer than on stage II a and II b, and it is quite the same that intraarterial chemotherapy is more effective for cervical squamous cell carcinoma than for adenocarcinoma. (authors)

52

Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix  

International Nuclear Information System (INIS)

A relation between apparent diffusion coefficient (ADC) values and tumor cellular density has been reported. The purpose of this study was to measure the ADC values of cervical cancers in the uterus and compare them with those of normal cervical tissues, and to test whether ADC could differentiate between normal and malignant cervical tissues in the uterus. Twelve consecutive female patients with cervical cancer of the uterus and ten female patients with other pelvic abnormalities were included in this study. ADC was measured at 1.5 T with b-factors of 0, 300 and 600 s/mm2 using single-shot echo-planar diffusion-weighted imaging and a parallel imaging technique. The mean ADC value of cervical cancer lesions was 1.09±0.20 x 10-3 mm2/s, and that of normal cervix tissue was 1.79±0.24 x 10-3 mm2/s (P<0.0001). In nine patients treated by chemotherapy and/or radiation therapy, the mean ADC value of the cervical cancer lesion increased significantly after therapy (P<0.001). The present study showed, with a small number of patients, that ADC measurement has a potential ability to differentiate between normal and cancerous tissue in the uterine cervix. Further study is necessary to determine the accuracy of ADC measurement in monitoring the treatment response. (orig.)

53

Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix  

Energy Technology Data Exchange (ETDEWEB)

A relation between apparent diffusion coefficient (ADC) values and tumor cellular density has been reported. The purpose of this study was to measure the ADC values of cervical cancers in the uterus and compare them with those of normal cervical tissues, and to test whether ADC could differentiate between normal and malignant cervical tissues in the uterus. Twelve consecutive female patients with cervical cancer of the uterus and ten female patients with other pelvic abnormalities were included in this study. ADC was measured at 1.5 T with b-factors of 0, 300 and 600 s/mm{sup 2} using single-shot echo-planar diffusion-weighted imaging and a parallel imaging technique. The mean ADC value of cervical cancer lesions was 1.09{+-}0.20 x 10{sup -3} mm{sup 2}/s, and that of normal cervix tissue was 1.79{+-}0.24 x 10{sup -3} mm{sup 2}/s (P<0.0001). In nine patients treated by chemotherapy and/or radiation therapy, the mean ADC value of the cervical cancer lesion increased significantly after therapy (P<0.001). The present study showed, with a small number of patients, that ADC measurement has a potential ability to differentiate between normal and cancerous tissue in the uterine cervix. Further study is necessary to determine the accuracy of ADC measurement in monitoring the treatment response. (orig.)

Naganawa, Shinji; Sato, Chiho; Ishigaki, Takeo [Nagoya University School of Medicine, Department of Radiology, Nagoya (Japan); Kumada, Hisashi; Miura, Shunichi [Toyohashi Municipal hospital, Department of Radiology, Toyohashi, Aich (Japan); Takizawa, Osamu [Siemens-Asahi Medical Technologies Ltd, Tokyo (Japan)

2005-01-01

54

Diagnostic values and limits of x-ray computed tomography in untreated uterine cervical cancer  

International Nuclear Information System (INIS)

Seventy patients with untreated uterine cervical cancer were prospectively evaluated by X-ray computed tomography (X-CT). Diagnoses were confirmed after radical hysterectomy for 44 cases, and by staging laparotomy for 26 cases. Paraaortic lymph node biopsies were performed for all patients. The results obtained were as follows: 1) X-CT was of little value in detecting pelvic lymph node metastasis. In comparison with pathological findings obtained from pelvic lymph node dissection, only 26 % of pelvic lymph node metastases were detected by X-CT. About 40 % of the lymph nodes with metastases, even if relatively large, were missed by X-CT. 2) X-CT was useful in detecting paraaortic lymph node metastasis. Its diagnostic accuracy equalled that of the clinical judgment of surgeons. X-CT could detect the lymph nodes which were 1 cm in diameter or larger. 3) X-CT was inferior to manual pelvic examinations under anesthesia for the diagnosis of parametrial involvement. 4) X-CT measurements of the vital tumor size at the uterine cervix correlated well with inspection of surgical specimens. Barrel-shaped tumors were easily detected by X-CT. 5) Excretory urography was not necessary when X-CT had been performed. The role of X-CT in clinical staging of uterine cervical cancer is also discussed. (author)

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Liquid-based slice cervical cytology test in radiation treated cancer of the uterine cervix  

International Nuclear Information System (INIS)

Objective: To observe the cervical cytological change after radiation therapy of cancer of uterine cervix and the clinical significance of Liquid-based cytology test (LCT). Methods: From 196 uterine cervical carcinoma patients, a total of 489 specimens of LCT were collected. All tests were performed one month after the conclusion of radiation treatment. Results: Detection rate of abnormal squamous epithelial cells was 40.3% (197/489), of which the findings of atypical squamous cells of undetermined significance (ASCUS), low grade squamous intraepithelial lesion (LSIL), high grade squamous intraepithelial lesion (HSIL) and squamous cell carcinoma(SCC) were observed in 20.1%, 5.3 %, 10.8% and 3.1% respectively. In benign reactive cervical cell detection, this article mainly describes the detection rate of inflammatory reactive cells which was 42.5%, of which the mild 6.34% inflammation took place, 19.4% moderate and 6.8% severe inflammation. All kinds of abnormal cell detection rates showed differences among each of the groups from 1 to 18 months of follow-up observation. Conclusions: Liquid-based cytology test may also be one of the predicting observation indexes if there is recrudescence locally in the future. (authors)

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Lumboaortic irradiation in uterine cervical cancer: Analysis of the literature  

International Nuclear Information System (INIS)

Background: Uterine cancer is a prevalent disease in Chile and it is one of the most frequent cancer locations treated in the National Chilean Cancer Institute. It is also common to receive young patients that have advanced tumors in stages IIB and IIIB with high risks of compromises of lymphatic nodes of pelvis and aortic-lumbar zones. The treatment for these kinds of cancers is radio-chemotherapy. Aims: Determinate if the radiotherapy of aortic-lumbar lymph nodes lowers the chance of relapsing or increase the survival rate in patients with evident compromise of aortic-lumbar lymph nodes and in those with high risk of compromise in that level. Method: Exhaustive analysis of the literature about the indication of radiotherapy of aortic-lumbar lymph nodes in cervix cancer which is classified in those where the radiotherapy treatment is done in patients with evident compromise of aortic-lumbar lymph-nodes, and those where de radiotherapy is done in patients with high risk of compromise in that level. Results: In patients with small cervix tumors and positive lymphoid nodes the LA lymphatic nodes treatment would be beneficial. However, patients that suffer massive pelvic disease (IIIB) or that have evidence of the disease, the benefit would not be so important. Conclusion: Patients with controllable pelvic disease and with high risk of having aortic-lumbar lymph nodes compromise are the most benefit of radiotherapy in aortic-lumbar lymph nodes (stages IA-B, IIA-B with positive lymph nodes)

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Estimating time to full uterine cervical dilation using genetic algorithm.  

Science.gov (United States)

The objectives of this study were to provide new parameters to better understand labor curves, and to provide a model to predict the time to full cervical dilation (CD). We studied labor curves using the retrospective records of 594 nulliparas, including at term, spontaneous labor onset, and singleton vertex deliveries of normal birth weight infants. We redefined the parameters of Friedman's labor curve, and applied a three-parameter model to the labor curve with a logistic model using the genetic algorithm and the Newton-Raphson method to predict the time necessary to reach full CD. The genetic algorithm is more effective than the Newton-Raphson method for modeling labor progress, as demonstrated by its higher accuracy in predicting the time to reach full CD. In addition, we predicted the time (11.4 hours) to reach full CD using the logistic labor curve using the mean parameters (the power of CD = 0.97 cm/hours, a midpoint of the active phase = 7.60 hours, and the initial CD = 2.11 cm). Our new parameters and model can predict the time to reach full CD, which can aid in the forecasting of prolonged labor and the timing of interventions, with the end goal being normal vaginal birth. PMID:22892163

Hoh, Jeong-Kyu; Cha, Kyung-Joon; Park, Moon-Il; Ting Lee, Mei-Ling; Park, Young-Sun

2012-08-01

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Clinical Significance of CENP-H Expression in Uterine Cervical Cancer  

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Full Text Available Objective This work aims to investigate the expression pattern and clinicopathologic significance of centromere protein H (CENP-H in uterine cervical cancer (UCC.Methods The level of CENP-H expression in the paraffin sections of 62 UCC cases was determined by the SP immunohistochemical method, with complete clinicopathologic data in all cases. Statistical analysis was conducted to evaluate the prognostic and diagnostic significance of CENP-H using SPSS13.0 software package.Results Immunohistochemical assay showed strong CENP-H expression in 61.29% (38/62 of the paraffin-embedded cervical cancer tissues. Statistical analysis revealed a strong correlation between the CENP-H expression and the clinical classification (P=0.038 of the cervical carcinoma. The expression increased with rise of the stages. The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002 and tumor stage (P=0.001 were independent prognostic markers for the survival of UCC patients. The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001.Conclusions CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC. It might be used as the important diagnostic and prognostic marker for cervical carcinoma patients, especially for those at early stage.

Mei-ying Weng

2012-09-01

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Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis  

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Full Text Available Abstract Background Bacterial vaginosis (BV, an alteration of vaginal flora involving a decrease in Lactobacilli and predominance of anaerobic bacteria, is among the most common cause of vaginal complaints for women of childbearing age. It is well known that BV has an influence in acquisition of certain genital infections. However, association between BV and cervical human papillomavirus (HPV infection has been inconsistent among studies. The objective of this meta-analysis of published studies is to clarify and summarize published literature on the extent to which BV is associated with cervical HPV infection. Methods Medline and Web of Science were systematically searched for eligible publications until December 2009. Articles were selected based on inclusion and exclusion criteria. After testing heterogeneity of studies, meta-analysis was performed using random effect model. Results Twelve eligible studies were selected to review the association between BV and HPV, including a total of 6,372 women. The pooled prevalence of BV was 32%. The overall estimated odds ratio (OR showed a positive association between BV and cervical HPV infection (OR, 1.43; 95% confidence interval, 1.11-1.84. Conclusion This meta-analysis of available literature resulted in a positive association between BV and uterine cervical HPV infection.

De Sutter Philippe

2011-01-01

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Role Of Family Planning Practices In The Control And Prevention of Uterine Cervical Cancer- A Multivariate Analysis  

OpenAIRE

Research Question: Does acceptance of family planning reduce the risk of uterine cervical cancer? Objective: To study the association between usage of contraceptive methods and cervical carcinogenesis. Study design: Case control study. Settings: Urban Area â€" Hospital Based. Participants: 160 women having different degrees of dysplasia and 173 women having normal pap smears. Statistical Analysis: Multivariate Analysis. Results: None of the three widely prevalent Family P...

Sharma S; Juneja A; Sehgal A; Sardana S; Singh V; Murthy N.S; Tuteja R.K

1995-01-01

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Effect of strong Posterisan ointment on rectal injuries after radiotherapy of uterine cervical cancer  

International Nuclear Information System (INIS)

In order to reduce the rectal injuries in the patients that received telecobalt irradiation after radical operation of uterine cervical cancer, strong posterisan ointment was employed. The ointment, composed of 0.16259 ml of death E. coli suspension, 2.5 mg of hydrocortisone and 4.98 mg of phenol per 1 gram, was given in 2 grams at one dose 2 to 3 time a day for 2 to 35 days according to severity of the symptoms. 60Co irradiation was performed in 150 to 200 rads 5 times a week. A total dose reached 4000 to 6000 rads, and the most patients were given 5000 rads. Of 9 patients, in whom the drug was given before and simultaneously with the onset of radiotherapy, irradiation was completed in 3 patients without any symptoms during radiotherapy. It suggested that the drug had a preventive effect on rectal injuries. Of 47 patients, in whom some symptoms were observed, the drug was effective in 30 patients, slightly effective in 8 and ineffective in 9, with the effective rate of 80.9 per cents. It was revealed that the drug was effective to the treatment of rectal injuries in radiotherapy of uterine cervical cancer. (Kumagai, S.)

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Nomogram Prediction of Overall Survival After Curative Irradiation for Uterine Cervical Cancer  

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Purpose: The purpose of this study was to develop a nomogram capable of predicting the probability of 5-year survival after radical radiotherapy (RT) without chemotherapy for uterine cervical cancer. Methods and Materials: We retrospectively analyzed 549 patients that underwent radical RT for uterine cervical cancer between March 1994 and April 2002 at our institution. Multivariate analysis using Cox proportional hazards regression was performed and this Cox model was used as the basis for the devised nomogram. The model was internally validated for discrimination and calibration by bootstrap resampling. Results: By multivariate regression analysis, the model showed that age, hemoglobin level before RT, Federation Internationale de Gynecologie Obstetrique (FIGO) stage, maximal tumor diameter, lymph node status, and RT dose at Point A significantly predicted overall survival. The survival prediction model demonstrated good calibration and discrimination. The bootstrap-corrected concordance index was 0.67. The predictive ability of the nomogram proved to be superior to FIGO stage (p = 0.01). Conclusions: The devised nomogram offers a significantly better level of discrimination than the FIGO staging system. In particular, it improves predictions of survival probability and could be useful for counseling patients, choosing treatment modalities and schedules, and designing clinical trials. However, before this nomogram is used clinically, it should be externally validatednically, it should be externally validated.

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CT and ultra low field (0.02 T) MR imaging of uterine cervical carcinoma  

International Nuclear Information System (INIS)

Nineteen pelvic MR and 21 CT examinations were performed in 21 patients with uterine cervical carcinoma. The results were compared with clinical (FIGO) staging in all patients, and with the histopathologic results after operation in 8. In the evaluation of local tumor growth CT agreed with clinical staging in 29%, MR imaging with clinical staging in 47% and CT with MR in 53%. The greatest discrepancy between the imaging methods and clinical examination was in the evaluation of parametrial extension. From 8 Stage I tumors with surgical confirmation the local tumor growth was overestimated with CT in 3 cases, with clinical examination in 2 and with MR imaging in 2 cases. CT and MR imaging at 0.02 T did not differ in the evaluation of parametrial tumor growth. Clinical examination overestimated parametrial growth but was relatively accurate in detecting vaginal wall involvement. MR imaging at 0.02 T is a convenient, inexpensive and accurate method for the local staging of early uterine cervical carcinoma. (orig.)

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Effect of 5'-DFUR used concurrently in radiotherapy and immunotherapy uterine cervical cancer. Pilot study  

International Nuclear Information System (INIS)

We conducted a preliminary controlled study in order to evaluate 5'-DFUR dose dependency in efficacy and safety in combination therapy of radiotherapy, 5'-DFUR and SPG for patients with uterine cervical cancer, which was regarded as suitable for cases of radiotherapy. The patients were randomly allocated into group A (5'-DFUR 600 mg/body/day) and group B (5'-DFUR 800 mg/body/day), who underwent radiotherapy with simultaneous administration of 5'-DFUR and SPG (20 mg twice/week or 40 mg/week). Those enrolled were 33 patients in stage II, III or IVa with histologically diagnosed primary squamous cell carcinoma of uterine cervix. CR was shown in 19, PR in 7, NC in 1, and PD in 2 out of 29 efficacy-evaluable cases, so the overall response rate was 89.7% (26/29, 95%CI 72.7%-97.8%). Regarding safety, some side effects were observed in 26 out of 33 safety-evaluable cases (81.3%, 95%CI 63.6%-92.8%), but no serious cases. No significant difference in efficacy and safety was observed between the two treatment groups. These results suggested that the combination therapy of radiotherapy, 5'-DFUR and SPG might be one of the therapies whose effectiveness must be confirmed for advanced squamous cell carcinoma of uterine cervix. To confirm dose dependency of 5'-DFUR, it seems further consideration with more patients is needed. (author)

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Uterine cervical cancer. Preoperative staging with magnetic resonance imaging; Zervixkarzinom. Praeoperatives Staging mittels Magnetresonanztomographie  

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The treatment of uterine cervical carcinoma is largely dependent on the tumor stage. Despite significant inaccuracies in the clinical examination, uterine cervical cancer remains the only gynecological form of cancer still largely staged according to clinical findings. Although imaging is still not included in the staging the recently published revised FIGO (Federation International de Gynecologie et d'Obstetrique) system encourages the use of modern cross-sectional imaging (magnetic resonance imaging MRI and computed tomography CT). Due to its high soft tissue contrast MRI allows excellent non-invasive assessment of the cervix with direct tumor delineation as well as assessment of the prognosis based on morphological factors. Studies in the literature report an accuracy of 93% for MRI in the preoperative assessment of tumor size and in the differentiation of operable from advanced cervical cancer. Therefore MRI is considered to be the optimal modality for diagnostic evaluation starting from FIGO stage IB1, for radiation therapy planning, and for exclusion of recurrence in follow-up. In this paper we give an overview of the role of magnetic resonance imaging in preoperative staging of uterine cervical cancer. (orig.) [German] Die Therapieplanung beim Zervixkarzinom ist weitgehend von der Stadieneinteilung nach FIGO (Federation International de Gynecologie et d'Obstetrique) abhaengig, die trotz erheblicher Ungenauigkeiten bei der klinischen Stadieneinteilung weiterhin aufgrund klinischer Untersuchungsbefunde erfolgt. Obwohl bildgebende Verfahren nach wie vor fuer die Stadieneinteilung nicht vorgesehen sind, wird im kuerzlich erschienen revidierten Stagingsystem der FIGO zum ersten Mal die Verwendung moderner Schnittbilddiagnostik (MRT und CT) befuerwortet. Die MRT ermoeglicht dank ihres hohen Weichteilkontrasts ein ausgezeichnetes nichtinvasives Staging des Zervixkarzinoms mit direkter Tumordarstellung sowie einer Prognoseabschaetzung anhand bildmorphologischer Faktoren. Nach Ergebnissen in der Literatur betraegt die Genauigkeit der MRT bei der praeoperativen Abschaetzung der Tumorgroesse sowie der Differenzierung operabler Zervixkarzinome von fortgeschrittenen Karzinomen 93%. Sie wird daher nicht nur als das Verfahren der Wahl zur diagnostischen Beurteilung ab FIGO-Stadium IB1 angesehen, sondern auch zur Strahlentherapieplanung sowie zum Rezidivausschluss im Rahmen der Nachsorge. In der folgenden Arbeit geben wir einen Ueberblick ueber die Rolle der MRT bei der praeoperativen Stadieneinteilung des Zervixkarzinoms. (orig.)

Collettini, F.; Hamm, B. [Charite-Universitaetsmedizin Berlin, Campus Charite Mitte, Klinik fuer Radiologie, Berlin (Germany)

2011-07-15

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Performance of FDG-PET/CT for diagnosis of recurrent uterine cervical cancer  

International Nuclear Information System (INIS)

The purpose is to evaluate the accuracy of integrated FDG-PET/CT, compared with PET alone, for diagnosis of suspected recurrence of uterine cervical cancer. Fifty-two women who had undergone treatment for histopathologically proven cervical cancer received PET/CT with suspected recurrence. PET-alone and integrated PET/CT images were evaluated by two different experienced radiologists by consensus for each investigation. A final diagnosis was confirmed by histopathology, radiological imaging, and clinical follow-up for over 1 year. Patient-based analysis showed that the sensitivity, specificity, and accuracy of PET/CT were 92.0% (23/25), 92.6% (25/27), and 92.3% (48/52), respectively, while for PET, the corresponding figures were 80.0% (20/25), 77.8% (21/27), and 78.8% (41/52), respectively. PET/CT resolved the false-positive PET results due to hypermetabolic activity of benign/inflammatory lesions and physiological variants, and was able to detect lung metastasis, local recurrence, peritoneal dissemination, para-aortic lymph node metastasis, and pelvic lymph node metastasis missed by PET alone. However, tiny local recurrence and lymph node metastasis could not be detected even by PET/CT. FDG-PET/CT is a useful complementary modality for providing good anatomic and functional localization of sites of recurrence during follow-up of patients with cervical cancer. (orig.)

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Assessment of the natural course and treatment of premalignant uterine cervical lesions in pregnancy  

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Full Text Available Introduction. Premalignant changes of the uterine cervix occur with similar frequency during pregnancy and in non­pregnant women. Due to the fact that any surgery on the cervix can jeopardize pregnancy, it is important to define the protocol of procedures for the treatment of these changes during pregnancy. Objective. The aim of the study was to investigate the natural course of premalignant cervical changes during pregnancy and the impact of their treatment on the pregnancy course. Methods. Study involved all patients with colposcopically, cytologically and hystopathologically diagnosed premalignant cervical changes during pregnancy from 2002 to 2008. Patients were divided into two groups according to the applied treatment during pregnancy: surgery or monitoring by regular colposcopic and cytological examinations. The two groups were compared concerning treatment outcome, persistence or regression of changes and pregnancy duration. Results. Study involved 58 patients. Spontaneous remission of lesions occurred after pregnancy in 63.79% of cases. Highgrade squamous intraepithelial lesion (H­SIL demonstrated a higher rate of persistency in comparison with low­grade squamous intraepithelial lesion (L­SIL (?2=25.115; p<0.05. Only one finding of L­SIL progressed into H­SIL in the monitored group. Patients who underwent conization during pregnancy had a significantly more frequent preterm deliveries (?2=14.369; p<0.05. Conclusion. The obtained high rate of spontaneous regression of cervical changes after pregnancy as well as the lower incidence of preterm births in patients who were not treated by conization during pregnancy, confirm that patients with premalignant cervical changes should be, if invasion is excluded, under follow­up throughout pregnancy by regular colposcopic and cytological examinations. Therapeutic conization, due to numerous complications, should be performed only when there is a suspected presence of a more severe form of the disease (micro invasive and invasive carcinoma.

Šljivan?anin Dragiša

2013-01-01

68

Dynamic contrast-enhanced MRI in the diagnosis of uterine cervical cancer  

International Nuclear Information System (INIS)

Objective: To investigate the imaging characteristics of dynamic contrast-enhanced MR imaging (DCE-MRI) in uterine cervical cancer(UCC), and to evaluate the efficacy of DCE-MRI in the diagnosis of UCC. Methods: A total of 39 cases of scratch-pathologically confirmed UCC patients with MRI data were analyzed (one case of carcinoma in sim being negative on MRI was excluded in this study). Time- intensity curves of ROI in pathological regions and adjacent normal regions were obtained and the enhanced rates at different times (16,32,48,64 and 300 s) were calculated. The ARSI% and MRSI% of various groups were compared with t test. Results: All the 39 lesions enhanced at 16 s in DCE, and there was maximum signal contrast between lesions and the surrounding normal tissue in the early arterial phase. ARSI% of tumor (1.97 ± 0.55)% was higher than normal tissue (1.22 ± 0.56 )%, and there was statistically significant difference between them (t=151.000, P3 cm group[(1.70 ± 0.25)% and (2.26 ± 0.18)%] were higher than ?3 cm group [(0.57 ± 0.16)% and (0.73 ± 0.04)%]. ARSI% and MRSI% were higher in the peri-uterine tissue infiltration group [(1.69 ± 0.21)% and (2.26 ± 0.11)%] than that of confined group [(0.63 ± 0.23)% and (0.83 ± 0.03)%] with statistically significant difference (P<0.05). The TIC of the 39 cases with UCC included type I in 25 cases(25/39), type II in 14 cases (14/39), and there was no type III cases. The TICs of the se III cases. The TICs of the surrounding normal tissue were of type III (26/39) and type II (11/39), and only 2 cases type I. Conclusions: The DCE-MRI can reflect the blood supply of the UCCs quantitatively. The early arterial phase in DCE-MRI can improve the detection rate of small lesions. The ARSI% and MRSI% may be helpful in some degree in prognostic assessment and staging of the uterine cervical cancer. (authors)

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Factores de riesgo para cáncer de cuello uterino / Risk factors for uterine cervical cancer  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish El cáncer del cuello uterino es una de las neoplasias malignas de mayor incidencia y mortalidad entre las mujeres de todas partes del mundo, hallazgo que resulta paradójico si se tiene en cuenta que el cuello uterino es de fácil acceso y existen estrategias debidamente probadas que permiten un diagn [...] óstico y tratamiento precoz. En esta revisión se describe detalladamente la epidemiología del cáncer del cuello uterino, en especial los factores de riesgo relacionados con la génesis de la neoplasia y su diagnóstico tardío. Abstract in english Cervical cancer is one of the most frequent neoplasms and one of the most common causes of death among women of reproductive age in the world. These figures are paradoxical if we consider that uterine cervix is easily accessible and that there are proven strategies to early diagnosis and effective t [...] reatments. In this paper we provide a detailed review of the epidemiology of cervical cancer, with emphasis on related risk factors associated with carcinogenesis and delayed diagnosis.

Ricardo, Ortiz Serrano; Claudia Janeth, Uribe Pérez; Luis Alfonso, Díaz Martínez; Yuriko Rafael, .

2004-06-01

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Clinicopathological analysis of 91 cases of uterine cervical cancer (including 38 cases of CIN III)  

International Nuclear Information System (INIS)

A total of 91 cases of uterine cervical cancer, consisting of 38 cases of carcinoma in situ (CIN III) and 53 cases of stage I-IV cervical cancer, were retrospectively and clinicopathologically analyzed. The standard treatment given to these patients consisted of hysterectomy or conization for CIN III; observation of cases of mild to moderate dysplasia; radical hysterectomy plus pelvic lymph node dissection for stage I and II cervical cancer; and radiotherapy for stage III and IV cervical cancer. Postoperative irradiation consisted of irradiation of the whole pelvis with 40-50 Gy. The patients who were not treated surgically underwent 40 Gy external irradiation of the whole pelvis, followed by an additional 20 Gy with shielding and internal irradiation with an RALS. When lymph node metastasis was present, the nodes were irradiated with 40-50 Gy. The mean age of the 38 patients with CIN III was 45.2 years old, and they were para 0-4. In 24 (63.2%) of them the cancer was detected by cytodiagnosis as part of screening. Radical hysterectomy, simple hysterectomy, and conization were performed in 25 patients, 7 patients, and 6 patients, respectively. No recurrences have been detected, and the survival rate is 100%. The mean age of the 53 patients with cervical cancer stage I-IV was 62.4 years old, and they were para 0-10. There were 25 patients with stage I disease, 15 patients with stage II disease, 6 patients with stage III, and 7 patients with stage IV, and their 5-year spatients with stage IV, and their 5-year survival rate was 82.4%, 68.8%, 66.7%, and 42.9%, respectively. Radioenteritis and radiocystitis occurred as adverse radiation effects. Pathologic factors influencing lymph node metastasis were examined by a multivariate analysis based on the data from 25 patients with stage I and II who underwent hysterectomy. The results of the analysis indicated the importance of screening and the choice of appropriate surgical method/technique, as well as the need for further investigation to determine the effective range of dissection to prevent lymph node metastasis. (K.H.)

71

Distribution of Uterin Cervical Lesions and Relation Between Age and Parity Rates in the Mardin Province  

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Full Text Available Objective: The aim of this study is to evaluate the incidence and distribution of cervical lesions and compare characteristics such as parity and age of the women in Mardin province.Material and Method: Pap smears were drawn from the women screened at Mardin Gynecology and Pediatric Diseases Hospital from 2008 to 2011. All cervicovaginal smears were conventional Pap smear samples evaluated according to the 2001 Bethesda system.Results: There were 3.332 patients in total, whose smears showed no lesions in 3.125 patients. The mean age and number of parities of those patients were 37.34±11.25 and 4.78±3.28. There were 207 smears showing any lesions in cervix; ASC-US, ASC-H, LSIL, HSIL, AGC, squamous cell carcinoma and endocervical adenocarcinoma in 151 (72.94%; 16 (7.72%; 20 (9.66%; 8 (3.86%; 10 (4.83%; 1 (0.48% and 1 (0.48% patient, respectively. The mean age and the parities of the patients were 37.63±10.77 years and 4,74±2,92. Although there was no difference between the control and lesion groups, the parity and the age of patients who had ?4 births in both the control and lesion groups were significantly higher than the patients with parities <4 births (p=0.000. There was no difference within the cervical lesion group comparing the ASC-US group with the total of the other lesions.Conclusion: High parity was one of the risk factor for having a lesion in uterine cervix in this population. This study represents an initial attempt to reflect the prevalence and the distribution of cervical lesions and their relation with the parity rates in the eastern regions in Turkey.

Gülay AYDO?DU

2013-01-01

72

External beam boost irradiation for clinically positive pelvic nodes in patients with uterine cervical cancer  

International Nuclear Information System (INIS)

The purpose of this study was to retrospectively analyze the treatment results of boost external beam radiotherapy (EBRT) to clinically positive pelvic nodes in patients with uterine cervical cancer. The study population comprised 174 patients with International Federation of Gynecology and Obstetrics (FIGO) stages 1B1-4A cervical cancer who were treated with definitive radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT). Patients with positive para-aortic or common iliac nodes (?10 mm in the shortest diameter, as evaluated by CT/MRI) were ineligible for the study. Fifty-seven patients (33%) had clinically positive pelvic nodes. The median maximum diameter of the nodes was 15 mm (range, 10-60 mm) and the median number of positive lymph nodes was two (range, one to four). Fifty-two of 57 patients (91%) with positive nodes were treated with boost EBRT (6-10 Gy in three to five fractions). The median prescribed dose of EBRT for nodes was 56 Gy. The median follow-up time for all patients was 66 months (range, 3-142 months). The 5-year overall survival rate, disease-free survival rate and pelvic control rate for patients with positive and negative nodes were 73% and 92% (P=0.001), 58% and 84% (P<0.001), and 83% and 92% (P=0.082), respectively. Five of 57 node-positive patients (9%) developed pelvic node recurrences. All five patients with nodal failure had concomitant cervical failure and/or distant metastases. No significant difference was observed with respect to the incidence or severity of late complications by application of boost EBRT. The current retrospective study demonstrated that boost EBRT to positive pelvic nodes achieves favorable nodal control without increasing late complications. (author)

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Preterm birth due to cervical insufficiency complicated by placenta accreta and postpartum haemorrhage managed by uterine artery embolisation  

OpenAIRE

In this report, we present the case of a young woman undergoing her second pregnancy, with early detected shortened cervix resulting in cervical cerclage procedure. At gestational week 24/25, she presented at a hospital with signs of intra-amniotic infection and spontaneous rupture of membranes. This resulted in pathological preterm delivery with massive postpartum bleeding, which was managed by bilateral uterine artery embolization. Reasons for preterm birth and management options are discus...

Elina Tetere; Anna Jekabsone; Ieva Kalere; Dace Matule

2014-01-01

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High-dose-rate brachytherapy for uterine cervical cancer: the results of different fractionation regimen  

International Nuclear Information System (INIS)

Although high-dose-rate (HDR) brachytherapy regimens have been practiced with a variety of modalities and various degrees of success, few studies on the subject have been conducted. The purpose of this study was to compare the results of local control and late complication rate according to different HDR brachytherapy fractionation regimens in uterine cervical cancer patients. From November 1992 to March 1998, 224 patients with uterine cervical cancer were treated with external beam irradiation and HDR brachytherapy. In external pelvic radiation therapy, the radiation dose was 45 ? 54 Gy (median dose 54 Gy) with daily fraction size 1.8 Gy, five times per week. In HDR brachytherapy, 122 patients (Group A) were treated with three times weekly with 3 Gy to line-A (isodose line of 2 cm radius from source) and 102 patients (Group B) underwent the HDR brachytherapy twice weekly with 4 or 4.5 Gy to line-A after external beam irradiation. Iridium-192 was used as the source of HDR brachytherapy. Late complication was assessed from grade 1 to 5 using the RTOG morbidity grading system. The local control rate (LCR) at 5 years was 80% in group A and 84% in group B (? = 0.4523). In the patients treated with radiation therapy alone, LCR at 5 years was 60.9% in group A and 76.9% in group B (? = 0.2557). In post-operative radiation therapy patients, LCR at 5 years was 92.6% in group A and 91.6% in group B (? 0.8867). The incidence of late complication was 18% (22 patients) and 29lication was 18% (22 patients) and 29.4% (30 patients), of bladder complication was 9.8% (12 patients) and 14.7% (15 patients), and of rectal complication was 9.8% (12 patients) and 21.6% (22 patients), in group A and B, respectively. Lower fraction sized HDR brachytherapy was associated with decrease in late complication (? =0.0405) (rectal complication, ? = 0.0147; bladder complication, ? =0.115). The same result was observed in postoperative radiation therapy patients (? = 0.0860) and radiation only treated patients (? =0.0370). For radiation only treated patients, a greater number of itemized studies on the proper fraction size of HDR brachytherapy, with consideration for stages and prognostic factors, are required. In postoperative radiation therapy, the fraction size of HDR brachytherapy did not have much effect on local control, yet the incidence of late complication increased with the elevation in fraction size. We suggest that HDR brachytherapy three times weekly with 3 Gy could be an alternative method of therapy

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Changes in Bone Mineral Density in Uterine Cervical Cancer Patients After Radiation Therapy  

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Purpose: To prospectively investigate the changes in bone mineral density (BMD) after pelvic radiation therapy in patients with uterine cervical cancer. Methods and Materials: Of 52 cervical cancer patients who received pelvic RT in our university hospital between 2009 and 2011, 46 patients without recurrence and who were followed up for more than 12 months were included in the study. The BMD of the irradiated region and nonirradiated regions, serum estradiol, tartrate-resistant acid phosphatase-5b, and N-terminal cross-linking telopeptide of collagen 1 were measured before, at 3 months after, and at 12 months after RT. The patient cohort was divided into 2 groups according to estradiol level before RT, and the groups were defined as postmenopausal (<40 pg/mL) and premenopausal (?40 pg/mL). Results: The mean BMDs within the irradiation field (lumbar vertebra 5) in the postmenopausal and the premenopausal groups were 0.825 and 0.910 g/cm{sup 2} before RT and 0.746 and 0.841 g/cm{sup 2} 12 months after RT, respectively. Significant decreases were observed in both groups (P<.05 and P<.01, respectively). In addition, in the premenopausal group the mean BMDs of the nonirradiated regions at thoracic vertebrae 9-12 and lumbar vertebrae 2-4 were 0.753 and 0.958 g/cm{sup 2} before RT and were significantly decreased to 0.706 and 0.921 g/cm{sup 2} 12 months after RT (P<.01 and P<.05, respectively). Estradiol significantly decreased 3 months after RT, whereas tartrate-resistant acid phosphatase-5b and N-terminal cross-linking telopeptide of collagen 1 continued to increase over time in the premenopausal group. Conclusions: A decrease in BMD in the irradiated region after RT was observed within 1 year, regardless of menopausal status. Furthermore, in premenopausal patients, pelvic RT caused a decrease in systemic BMD.

Okonogi, Noriyuki; Saitoh, Jun-ichi; Suzuki, Yoshiyuki, E-mail: syoshi@gunma-u.ac.jp; Noda, Shin-ei; Ohno, Tatsuya; Oike, Takahiro; Ohkubo, Yu; Ando, Ken; Sato, Hiro; Nakano, Takashi

2013-12-01

76

The effect of uterine motion and uterine margins on target and normal tissue doses in intensity modulated radiation therapy of cervical cancer  

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In intensity modulated radiation therapy (IMRT) of cervical cancer, uterine motion can be larger than cervix motion, requiring a larger clinical target volume to planning target volume (CTV-to-PTV) margin around the uterine fundus. This work simulates different motion models and margins to estimate the dosimetric consequences. A virtual study used image sets from ten patients. Plans were created with uniform margins of 1 cm (PTVA) and 2.4 cm (PTVC), and a margin tapering from 2.4 cm at the fundus to 1 cm at the cervix (PTVB). Three inter-fraction motion models (MM) were simulated. In MM1, all structures moved with normally distributed rigid body translations. In MM2, CTV motion was progressively magnified as one moved superiorly from the cervix to the fundus. In MM3, both CTV and normal tissue motion were magnified as in MM2, modeling the scenario where normal tissues move into the void left by the mobile uterus. Plans were evaluated using static and percentile DVHs. For a conventional margin (PTVA), quasi-realistic uterine motion (MM3) reduces fundus dose by about 5 Gy and increases normal tissue volumes receiving 30-50 Gy by ~5%. A tapered CTV-to-PTV margin can restore fundus and CTV doses, but will increase normal tissue volumes receiving 30-50 Gy by a further ~5%.

Gordon, J. J.; Weiss, E.; Abayomi, O. K.; Siebers, J. V.; Dogan, N.

2011-05-01

77

The effect of uterine motion and uterine margins on target and normal tissue doses in intensity modulated radiation therapy of cervical cancer  

International Nuclear Information System (INIS)

In intensity modulated radiation therapy (IMRT) of cervical cancer, uterine motion can be larger than cervix motion, requiring a larger clinical target volume to planning target volume (CTV-to-PTV) margin around the uterine fundus. This work simulates different motion models and margins to estimate the dosimetric consequences. A virtual study used image sets from ten patients. Plans were created with uniform margins of 1 cm (PTVA) and 2.4 cm (PTVC), and a margin tapering from 2.4 cm at the fundus to 1 cm at the cervix (PTVB). Three inter-fraction motion models (MM) were simulated. In MM1, all structures moved with normally distributed rigid body translations. In MM2, CTV motion was progressively magnified as one moved superiorly from the cervix to the fundus. In MM3, both CTV and normal tissue motion were magnified as in MM2, modeling the scenario where normal tissues move into the void left by the mobile uterus. Plans were evaluated using static and percentile DVHs. For a conventional margin (PTVA), quasi-realistic uterine motion (MM3) reduces fundus dose by about 5 Gy and increases normal tissue volumes receiving 30-50 Gy by ?5%. A tapered CTV-to-PTV margin can restore fundus and CTV doses, but will increase normal tissue volumes receiving 30-50 Gy by a further ?5%.

78

The effect of uterine motion and uterine margins on target and normal tissue doses in intensity modulated radiation therapy of cervical cancer  

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In intensity modulated radiation therapy (IMRT) of cervical cancer, uterine motion can be larger than cervix motion, requiring a larger clinical target volume to planning target volume (CTV-to-PTV) margin around the uterine fundus. This work simulates different motion models and margins to estimate the dosimetric consequences. A virtual study used image sets from ten patients. Plans were created with uniform margins of 1 cm (PTV{sub A}) and 2.4 cm (PTV{sub C}), and a margin tapering from 2.4 cm at the fundus to 1 cm at the cervix (PTV{sub B}). Three inter-fraction motion models (MM) were simulated. In MM1, all structures moved with normally distributed rigid body translations. In MM2, CTV motion was progressively magnified as one moved superiorly from the cervix to the fundus. In MM3, both CTV and normal tissue motion were magnified as in MM2, modeling the scenario where normal tissues move into the void left by the mobile uterus. Plans were evaluated using static and percentile DVHs. For a conventional margin (PTV{sub A}), quasi-realistic uterine motion (MM3) reduces fundus dose by about 5 Gy and increases normal tissue volumes receiving 30-50 Gy by {approx}5%. A tapered CTV-to-PTV margin can restore fundus and CTV doses, but will increase normal tissue volumes receiving 30-50 Gy by a further {approx}5%.

Gordon, J J; Weiss, E; Abayomi, O K; Siebers, J V; Dogan, N, E-mail: jjgordon@vcu.edu [Department of Radiation Oncology, Virginia Commonwealth University, PO Box 980058, Richmond, VA 23298 (United States)

2011-05-21

79

Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy  

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Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of 69 Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

80

Relationship between the cervical uterine cancer evolution and selenium concentration in urine determined by NAA  

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Neutron activation analysis of Se in urine reaches an optimum sensitivity (few ppb) and precision (± 12%) when the traces are complexed without using a carrier by ammonium pyrrolidindithiocarbamate (APDC) at pH 1.5-2 and adsorbed on activated carbon filters. In this way the selenium traces analysis have been carried out through 77mSe in 45 urine samples on a pre-separation basis by cyclic activation of the carbon filters. The selenium concentration in our blanks is virtually zero, because APDC proved to be selenium free and selenium mass in 50 mg of activated carbon used as a filter is 20 times below our qualitative detection limit and 144 times below our quantitative detection limit. The samples were first of day urine from healthy and ill women suffering cervical uterine cancer, at different evolution stages: incipient, intermediate and advanced, with no treatment, and surgery, radiotherapy, chemotherapy, or a combined treatment. The results show a consistent trend to increase the selenium trace concentration during the intermediate stage, whereas it is the same than normal for incipient cases, and it decreases to the lowest concentrations for advanced cases. (author)

81

Two cases of pyogenic osteomyelitis of pubic bone after irradiation for cervical carcinoma of the uterine  

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Two cases of pyogenic osteomyelitis of pubic bone occurred after irradiation of cervical carcinoma were reported. Case 1: A 69-year-old female received external irradiation of 50 Gy from November 1993 to April 1994 after supravaginal uterine amputation. The left melosalgia and pain at left pubic region appeared from July 1994. On the MRI, bone marrow of the left pubic region showed low brightness by T1 weighted image and equal brightness by T2 weighted image, and the image was enhanced by gadolinium. An abscess in external obturator muscle was suspected. High accumulation was recognized by bone scintigram at the left pubic region. No bacterial infection was recognized. Focus was removed in May 1995. Case 2: A 80-year-old female received external irradiation of 50 Gy and intracavitary irradiation of 30 Gy in May 1992. Pain at left pubic region appeared from June 1993. Dilation of pubic symphysis and osteoclasia of the left pubic bone were detected on the plain radiograph in March 1995. On the MRI, the left pubic bone marrow showed low brightness by T1 weighted image and equal brightness by T2 weighted image, and image was enhanced by gadolinium. An abscess in small pelvic cavity was suspected. Streptococcus agalactae was detected in abscess, and PIPC was administered by drip infusion for five weeks. They are currently alive and doing well about three years later. (K.H.)

Moriyama, Ichiro; Matsumoto, Morio; Yamauchi, Kenji; Horiuchi, Kiwamu; Morisue, Hikaru; Yamagishi, Masaaki; Tanaka, Mamoru [Tachikawa Hospital, Tokyo (Japan)

1999-03-01

82

Two cases of pyogenic osteomyelitis of pubic bone after irradiation for cervical carcinoma of the uterine  

International Nuclear Information System (INIS)

Two cases of pyogenic osteomyelitis of pubic bone occurred after irradiation of cervical carcinoma were reported. Case 1: A 69-year-old female received external irradiation of 50 Gy from November 1993 to April 1994 after supravaginal uterine amputation. The left melosalgia and pain at left pubic region appeared from July 1994. On the MRI, bone marrow of the left pubic region showed low brightness by T1 weighted image and equal brightness by T2 weighted image, and the image was enhanced by gadolinium. An abscess in external obturator muscle was suspected. High accumulation was recognized by bone scintigram at the left pubic region. No bacterial infection was recognized. Focus was removed in May 1995. Case 2: A 80-year-old female received external irradiation of 50 Gy and intracavitary irradiation of 30 Gy in May 1992. Pain at left pubic region appeared from June 1993. Dilation of pubic symphysis and osteoclasia of the left pubic bone were detected on the plain radiograph in March 1995. On the MRI, the left pubic bone marrow showed low brightness by T1 weighted image and equal brightness by T2 weighted image, and image was enhanced by gadolinium. An abscess in small pelvic cavity was suspected. Streptococcus agalactae was detected in abscess, and PIPC was administered by drip infusion for five weeks. They are currently alive and doing well about three years later. (K.H.)

83

Expression of HPV-16 E6 Protein and p53 Inactivation Increases the Uterine Cervical Cancer Invasion.  

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Human papillomavirus infection (HPV-16) and expression of HPV E6 protein are the major risk factors of cervical cancer. Studies reported that expression of E6 protein adversely affect the function of p53 and thus involved in tumor progression. In the present study, we made an attempt to analyze the prevalence of HPV-16 association, E6 and p53 expression in cervical cancer tissues.Uterine cervical cancer (n=10) and corresponding normal epithelium tissues (n=10) were collected at the time of surgery. The HPV-16 integration and E6 expression were analyzed by PCR and immunohistostaining. Further, p53 and Ki67 expression were analyzed by immunohistostaining. Telomerase was detected using a modified TRAP (telomerase repeat amplification protocol) assay.We have found that almost 90% of the collected cervical cancer DNA samples showed positivity to HPV-16 and more than 60% of DNA samples were E6 positive. Further, these tissues were highly positive to p53 and Ki67 protein which contribute to apoptosis resistance and increased cell proliferation. We also found elevated level of telomerase expression in cancer tissues compared to control.The association of HPV infection and E6 expression increases the risk of cervical cancer. Further, E6 expression is the cause for inactivation of p53 in tumor tissues and deregulated cell proliferation and thus favors for tumor invasion. PMID:24831244

Yang, X; Lu, L

2015-02-01

84

Survival prediction using artificial neural networks in patients with uterine cervical cancer treated by radiation therapy alone  

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We evaluated the usefulness of artificial neural networks (ANNs) for survival prediction in patients with uterine cervical cancer treated by radiotherapy. We used data from 134 patients with uterine cervical cancer treated by combined external and high-dose-rate remote afterloading intracavitary radiotherapy between 1978 and 1993. The ANNs were trained using the data from 67 randomly selected patients. Using the trained ANNs, we predicted the 5-year survival in the remaining 67 patients, and compared it with the known 5-year survival. The performance of the ANNs was evaluated using a receiver operating characteristic (ROC) curve and was compared using the area under the ROC curve (Az). When fundamental factors, such as age, performance status, hemoglobin, total protein, International Federation of Gynecology and Obstetrics (FIGO) stage, and histological type were used as inputs in the ANNs, Az was 0.5483±0.0145 (mean±SD). When the histological grading of radiation effect determined by periodic biopsy examination was used in addition to the fundamental factors, Az was highest (0.7782±0.0105). When the cytological grading of radiation effect by the periodic smear was used in addition to the fundamental factors, Az was 0.5523±0.0135, which was not significantly different from that when only the fundamental factors were used. ANNs allow us to evaluate the importance of prognostic factors, and make it possible to predict the survival of each patient. Using ANNs, the coal of each patient. Using ANNs, the combination of histological grading of radiation effect determined by periodic biopsy examination, in addition to the fundamental factors, is the most effective for prediction of survival in patients with uterine cervical cancer. (author)

85

Postoperative radiotherapy for uterine cervical cancer. Results of the 1995-1997 patterns of care process survey in Japan  

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The objective of this study was to determine the average national practice of postoperative radiotherapy (RT) for uterine cervical cancer in Japan. The Japanese Patterns of Care Study (PCS) reviewed the process of care employed for 455 uterine cervical cancer patients who were treated with surgery followed by postoperative RT during 1995-1997. Cases with missing data were excluded from calculations of percentage and significance for each of the surveyed items. According to International Federation of Gynecology and Obstetrics (FIGO) stages, 198 patients (45%) were in stage I, 52 patients (12%) were in stage IIA, 146 patients (33%) were in stage IIB and 46 patients (10%) were in stage III/IVA. The most common surgical procedure among the patients was radical hysterectomy (73%). Three hundred and seventy patients (82%) were treated with external beam RT (ERT) alone, and 74 patients (17%) were treated with a combination of ERT and intracavitary RT (ICRT). A midline block was used for the pelvic field in 63 patients (14%). Only seven patients (2%) were treated with extended field ERT. Pelvic ERT was most often performed using anterior posterior-posterior anterior (AP-PA) opposed fields for 431 patients (97%). A majority of the patients (312 patients, 70%) were treated with a total dose of 45.0-50.4 Gy for ERT. Chemotherapy (CT) was administered to 178 patients (40%), neoadjuvant preoperative CT was administered to 80 patients (22%) and concurrent CT with postoperative RT ) and concurrent CT with postoperative RT was administered to 29 patients (8%). This PCS established the national practice average of postoperative RT for uterine cervical cancer. Follow-up studies need to be conducted to determine whether the observed differences in treatment processes affect outcomes. (author)

86

Role of CD24 Protein in Predicting Metastatic Potential of Uterine Cervical Squamous Cell Carcinoma in Patients Treated With Radiotherapy  

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Purpose: The protein CD24 is a cell surface protein that appears to function as an adhesion molecule; its expression has been shown to correlate with prognosis in a variety of tumors. The aim of this study was to evaluate the immunoreactivity of uterine cervical squamous cell carcinoma to CD24 and determine whether CD24 is associated with clinical and pathologic parameters, including prognosis. Methods and Materials: The expression of CD24 protein was immunohistochemically studied in 73 cases of uterine cervical squamous cell carcinoma. All patients were treated with definitive radiotherapy alone or with concurrent chemoradiotherapy. Two pathologists independently analyzed the immunostaining; they did not have knowledge of the patient outcomes and evaluated any changes according to the percentage of tumor cells stained as follows: negative, 5% reactive. Results: Positive staining was found in 43 cases (58.9%). The immunoreactivity did not correlate with age, International Federation of Gynecology and Obstetrics stage, lymph node metastasis, or tumor size. For patients who were CD24 negative, the total failure and distant metastasis rates were decreased about 20% compared with the rates for patients who were CD24 positive. On univariate analysis, the 5-year distant metastasis-free survival rate of CD24-negative patients was significantly greater than that of the CD24-positive patients (84.7% vs. 66.7%, respectively, p = 0.0497). The Interna7%, respectively, p = 0.0497). The International Federation of Gynecology and Obstetrics stage and CD24 expression were significantly associated with distant metastasis-free survival on multivariate analysis. Conclusions: CD24 expression was a significant independent prognostic factor for distant metastasis-free survival in patients with uterine cervical squamous cell carcinoma. In the future, prospective determination of CD24 expression might aid clinical practice in the selection of the appropriate therapy for individual patients

87

Predictive role of post-treatment [18F]FDG PET/CT in patients with uterine cervical cancer  

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Objective: To evaluate the efficacy of post-treatment positron emission tomography (PET)/computed tomography (CT) for identification of tumor recurrence, and to determine whether [18F]fluorodeoxyglucose (FDG) uptake measured as the maximum standardized uptake value (SUVmax) has predictive role regarding survival in patients with uterine cervical cancer. Methods: Medical records from 276 women with uterine cervical cancer who had post-treatment [18F]FDG PET/CT performed were retrospectively reviewed. Results of PET/CT scans were compared with histological or clinical examination. Results: Ninety-five (34.4%) of the 276 patients had documented recurrence by either surgical biopsy or clinical and imaging follow-up. Median duration from treatment to PET/CT scan was 24 months (range, 6–307). The overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of post-treatment PET/CT were 94.7%, 87.8%, 80.4%, 97%, and 90.2%, respectively. The PET/CT scan modified both the diagnostic or treatment plan in 67 patients (24.3%). Patients were divided into two groups according to cut-off SUVmax established on the basis of ROC analysis (<5.25 vs. ?5.25), and there was a significant difference in OS between groups (p = 0.001). In addition, the 5-year progression-free survival (PFS) and OS rates of patients with a negative PET/CT scan for recurrence were significantly better than those with a positive PET/CT (98.62% vs. 17.83%, p < 0.0001 for PFS, 99.31% vs. 85.38%, p = 0.0015 for OS). Conclusion: Post-treatment PET/CT scan is a sensitive and accurate surveillance modality, and provides prognostic information in uterine cervical cancer. Furthermore, it may allow individualization of patient care.

88

Uterine Cancer  

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... only cancer the Pap test screens for is cervical cancer. Routine testing for uterine cancer is not recommended for women who have no symptoms. This is why you need to know the signs of uterine cancer and see your doctor if ...

89

Preterm birth due to cervical insufficiency complicated by placenta accreta and postpartum haemorrhage managed by uterine artery embolisation  

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Full Text Available In this report, we present the case of a young woman undergoing her second pregnancy, with early detected shortened cervix resulting in cervical cerclage procedure. At gestational week 24/25, she presented at a hospital with signs of intra-amniotic infection and spontaneous rupture of membranes. This resulted in pathological preterm delivery with massive postpartum bleeding, which was managed by bilateral uterine artery embolization. Reasons for preterm birth and management options are discussed. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 746-748

Elina Tetere

2014-06-01

90

Blood flow MR imaging of the uterine arteries and of normal and malignant cervical tissue. Initial experiences with a 2D-STAR technique  

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Purpose. The aim of this pilot study was to evaluate a 2D-STAR technique as a non contrast-enhanced approach to demonstrate the uterine artery and its branches and to assess the cervical uterine blood flow in healthy volunteers and in patients with advanced uterine cervical carcinoma. Materials and methods. Seven healthy volunteers (mean age, 29 years) and twentytwo patients (mean age, 52 years) with advanced cancer of the uterine cervix (FIGO IIB-IVA) were prospectively examined by 2D-STAR imaging at different inversion delay times (300 ms-1900 ms) which showed the passage of a blood bolus through normal and malignant tissue of the uterine cervix. Results. The uterine artery was well visualized with short inversion delay times of 300 ms to 500 ms. It was characterized as single or multiple helical loops before dividing into its intracervical branches. The intracervical branching was observed at inversion delay times of 500 ms-700 ms. With longer inversion delay times arterial signal enhancement disappeared and cervical tissue enhancement was noted. Enhancement of benign tissue was observed at inversion delay times of 1100 ms-1700 ms, and in malignant tissue at shorter inversion delay times of 900 ms-1300 ms. The maximum of this diffuse signal enhancement of benign tissue was seen at inversion dealy times of 1500 ms (1100 ms-1700 ms), in malignant tissue at significantly (P<0.05) shorter inversion delay times of 1100 ms (900 ms to 1300). (orig.)s to 1300). (orig.)

91

A novel functional site of extracellular matrix metalloproteinase inducer (EMMPRIN) that limits the migration of human uterine cervical carcinoma cells.  

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EMMPRIN (extracellular matrix metalloproteinase inducer)/CD147, a membrane-bound glycoprotein with two extracellular loop domains (termed loops I and II), progresses tumor invasion and metastasis by increasing the production of matrix metalloproteinase (MMP) in peritumoral stoma cells. EMMPRIN has also been associated with the control of migration activity in some tumor cells, but little is known about how EMMPRIN regulates tumor cell migration. In the present study, EMMPRIN siRNA suppressed the gene expression and production of EMMPRIN in human uterine cervical carcinoma SKG-II cells. An in vitro scratch wound assay showed enhancement of migration of EMMPRIN-knockdown SKG-II cells. In addition, the SKG-II cell migration was augmented by adding an E. coli-expressed human EMMPRIN mutant with two extracellular loop domains (eEMP-I/II), which bound to the cell surface of SKG-II cells. However, eEMP-I/II suppressed the native EMMPRIN-mediated augmentation of proMMP-1/procollagenase-1 production in a co-culture of the SKG-II cells and human uterine cervical fibroblasts, indicating that the augmentation of SKG-II cell migration resulted from the interference of native EMMPRIN functions by eEMP-I/II on the cell surface. Furthermore, a systematic peptide screening method using nine synthetic EMMPRIN peptides coding the loop I and II domains (termed EM1-9) revealed that EM9 (170HIENLNMEADPGQYR184) facilitated SKG-II cell migration. Moreover, SKG-II cell migration was enhanced by administration of an antibody against EM9, but not EM1 which is a crucial site for the MMP inducible activity of EMMPRIN. Therefore, these results provide novel evidence that EMMPRIN on the cell surface limits the cell migration of human uterine cervical carcinoma cells through 170HIENLNMEADPGQYR184 in the loop II domain. Finally, these results should provide an increased understanding of the functions of EMMPRIN in malignant cervical carcinoma cells, and could contribute to the development of clinical strategies for cervical cancer therapy. PMID:21994090

Sato, Takashi; Watanabe, Mami; Hashimoto, Kei; Ota, Tomoko; Akimoto, Noriko; Imada, Keisuke; Nomizu, Motoyoshi; Ito, Akira

2012-01-01

92

Neoadjuvant chemotherapy with bleomycin, ifosfamide and nedaplatin (NAC-BIN) followed by radiotherapy in locoregionally advanced uterine cervical cancer  

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Twelve patients with locoregionally advanced uterine cervical cancer (IIIB: 10, IVA: 2) were treated with neoadjuvant chemotherapy consisting of bleomycin, ifosfamide, and nedaplatin (NAC-BIN) and full dose radical radiotherapy. NAC-BIN achieved one complete response and seven partial responses, for a response rate of 67%. Hematologic toxicity was the most common side effect. Five experienced grade 3{<=}leukopenia, and three had grade 3{<=}anemia. With the mean follow-up of 25 months (range: 9-52 months), nine of 12 patients developed recurrence. Eight had pelvic recurrence alone, and one had both pelvic recurrence and distant metastases. The 2-year pelvic control rate, disease-free survival rate (DFS), and absolute survival rate (AS) were 25%, 25%, and 42%, respectively. The 2-year DFS and AS for patients who responded well to NAC-BIN (CR+PR) was 38% and 63%, whereas for those with a poor response (NC) were 0%. From these results, we consider that preoperative NAC-BIN should not be indicated for patients with unresectable stage (stage III{<=}) uterine cervical cancer, because poor responders must subsequently be treated with definitive radiotherapy and may suffer poor prognosis. (author)

Toita, Takafumi; Ogawa, Kazuhiko; Kakinohana, Yasumasa; Adachi, Genki; Nishikuramori, Yukiko; Murayama, Sadayuki [Ryukyus Univ., Nishihara, Okinawa (Japan). School of Medicine

2000-06-01

93

Neoadjuvant chemotherapy with bleomycin, ifosfamide and nedaplatin (NAC-BIN) followed by radiotherapy in locoregionally advanced uterine cervical cancer  

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Twelve patients with locoregionally advanced uterine cervical cancer (IIIB: 10, IVA: 2) were treated with neoadjuvant chemotherapy consisting of bleomycin, ifosfamide, and nedaplatin (NAC-BIN) and full dose radical radiotherapy. NAC-BIN achieved one complete response and seven partial responses, for a response rate of 67%. Hematologic toxicity was the most common side effect. Five experienced grade 3?leukopenia, and three had grade 3?anemia. With the mean follow-up of 25 months (range: 9-52 months), nine of 12 patients developed recurrence. Eight had pelvic recurrence alone, and one had both pelvic recurrence and distant metastases. The 2-year pelvic control rate, disease-free survival rate (DFS), and absolute survival rate (AS) were 25%, 25%, and 42%, respectively. The 2-year DFS and AS for patients who responded well to NAC-BIN (CR+PR) was 38% and 63%, whereas for those with a poor response (NC) were 0%. From these results, we consider that preoperative NAC-BIN should not be indicated for patients with unresectable stage (stage III?) uterine cervical cancer, because poor responders must subsequently be treated with definitive radiotherapy and may suffer poor prognosis. (author)

94

An assessment of interfractional uterine and cervical motion: Implications for radiotherapy target volume definition in gynaecological cancer  

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Purpose: To assess interfractional movement of the uterus and cervix in patients with gynaecological cancer to aid selection of the internal margin for radiotherapy target volumes. Methods and materials: Thirty-three patients with gynaecological cancer had an MRI scan performed on two consecutive days. The two sets of T2-weighted axial images were co-registered, and the uterus and cervix outlined on each scan. Points were identified on the anterior uterine body (Point U), posterior cervix (Point C) and upper vagina (Point V). The displacement of each point in the antero-posterior (AP), supero-inferior (SI) and lateral directions between the two scans was measured. The changes in point position and uterine body angle were correlated with bladder volume and rectal diameter. Results: The mean difference (±1SD) in Point U position was 7 mm (±9.0) in the AP direction, 7.1 mm (±6.8) SI and 0.8 mm (±1.3) laterally. Mean Point C displacement was 4.1 mm (±4.4) SI, 2.7 mm (±2.8) AP, 0.3 (±0.8) laterally, and Point V was 2.6 mm (±3.0) AP and 0.3 mm (±1.0) laterally. There was correlation for uterine SI movement in relation to bladder filling, and for cervical and vaginal AP movement in relation to rectal filling. Conclusion: Large movements of the uterus can occur, particularly in the superior-inferior and anterior-posterior directions, but cervical displacement is less marked. Rectal filling may affect cervical position, while bladder filling has more impact on uterineilling has more impact on uterine body position, highlighting the need for specific instructions on bladder and rectal filling for treatment. We propose an asymmetrical margin with CTV-PTV expansion of the uterus, cervix and upper vagina of 15 mm AP, 15 mm SI and 7 mm laterally and expansion of the nodal regions and parametria by 7 mm in all directions

95

Delayed presentation of pharyngeal erosion after anterior cervical discectomy and fusion.  

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Dysphagia after anterior cervical discectomy and fusion (ACDF) is common, with a prevalence ranging between 28% and 57% of cases. However, nearly all cases resolve spontaneously within 2 years, thus identifying patients who require more detailed or invasive work-up is a challenging task for clinicians. A review of literature reveals a paucity of case reports detailing work-up and successful management options. The authors performed a clinical and radiographic review of a case of a 47-year-old female who presented with persistent dysphagia 3 years following anterior cervical spine surgery and was found to have an erosive pharyngeal defect with exposed spinal hardware. The diagnosis was made with direct laryngoscopy and treatment consisted of plate removal and pharyngeal repair, followed by revision fusion with deformity correction. This case and the accompanying pertinent review of the literature highlight the importance of a thorough evaluation of dysphagia, especially in the mid- and late-term postoperative period following ACDF, when most cases of dysphagia should have been resolved. Correctly identifying the underlying etiology of dysphagia may lead to improved revision of ACDF outcomes. Unresolved dysphagia should be a red flag for surgeons as it may be the presentation of erosive esophageal/pharyngeal damage, a rare but serious complication following ACDF. PMID:25699193

Nathani, Amit; Weber, Alexander E; Wahlquist, Trevor C; Graziano, Gregory P; Park, Paul; Patel, Rakesh D

2015-01-01

96

Expression of the inhibitor of DNA-binding (ID)-1 protein as an angiogenic mediator in tumour advancement of uterine cervical cancers.  

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The ID protein, an inhibitor of basic helix-loop-helix (HLH) transcription factors, has been involved in multiple cellular processes. To investigate the association between tumour advancement and ID expressions of uterine cervical cancers, the levels of ID-1, ID-2 and ID-3 mRNAs were determined by real-time reverse transcription-polymerase chain reaction and the histoscore with the localisation of ID-1 was determined by immunohistochemistry and patient survival in 60 patients. ID-1 histoscores and mRNA levels both significantly (P<0.05) increased in uterine cervical cancers according to clinical stage regardless of histopathological type or lymph node metastasis. Furthermore, the 36-month survival rate of the 30 patients with high ID-1 was poor (60%), whereas that of the other 30 patients with low ID-1 was significantly higher (83%). ID-1 histoscores and mRNA levels significantly (P<0.0001) correlated with microvessel counts in uterine cervical cancers. Tumour cells show mostly diffuse to strong cytoplasmic expression of ID-1 and also very faint expression in endothelial cells. Moreover, ID-1 expression not only correlated with microvessel counts but also correlated significantly with histoscore. Therefore, ID-1 might work on tumour advancement through angiogenic activity and is considered to be a candidate for a prognostic indicator in uterine cervical cancers. PMID:19002177

Maw, M K; Fujimoto, J; Tamaya, T

2008-11-18

97

Neoadjuvant Intra-Arterial Chemotherapy for Locally Advanced Uterine Cervical Cancer: Clinical Efficacy and Factors Influencing Response  

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Purpose: To evaluate the effects of neoadjuvant intra-arterial chemotherapy (NAIC) for locally advanced uterine cervical cancer, and to analyze factors influencing the response to the chemotherapy. Methods: Thirty-four patients with invasive cervical cancer more than 4 cm in diameter were enrolled in this study. NAIC was performed using cisplatin-based regimens. The response was assessed by magnetic resonance imaging (MRI) and examination of surgical specimens. Pretreatment factors involved in the response to NAIC were evaluated and the relationship between the factors and the prognosis was assessed. Results:Clinical response was achieved in 28 (82%) patients. Thirty-one of 49 invasions in the parametrial halves disappeared. Seventeen of 28 lymphnode swellings responded to NAIC. Six of the 14 stage III patients became operable. In the 19 surgical cases, pathologically complete responses were found in four. Twenty-eight of the 38 parametrial halves were free from cancer. No lymph node metastases were found in eight patients. Initial tumor volume was found to be an independent, significant determining factor of the response to NAIC. Patients with initial tumor volumes less than 80 cm3 had a significantly better estimated 5-year disease-free survival rate compared with those with larger tumors. Conclusion: NAIC for locally advanced cervical cancer is useful for preoperative tumor reduction.Tumor volume is a significant determining factor for the response to NA determining factor for the response to NAIC

98

Expression of bcl-2 and bax in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix.  

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Bcl-2 protein together with the pro-apoptotic protein bax, are thought to function by forming homo- and heterotypic dimers which control the progression to apoptosis. In this immunohistochemical study we investigated the expression of bcl-2 and bax apoptosis related proteins in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. Twenty-four cervical intraepithelial neoplasias grade 1-2 (CIN I/II), 38 grade 3 (CIN III), and 53 invasive squamous cell carcinomas (ISCC) were investigated by immunohistochemical staining for bcl-2 and bax protein. Bcl-2 immunoreactivity was found in five of the 24 CIN I/II cases (20.8%), 18 of 38 CIN II cases (47.4%) and nine of 53 ISCC cases (17%). The positivity for CIN III was significantly higher than for CIN I/II or ISCC (p=0.0351 and p=0.0018, respectively). The percentage of bax immunopositivity was somewhat higher in CIN III than in CIN I/II but this slight difference was not statistically significant. Correlation of the immunostaining results with tumor grade revealed a significant difference for bcl-2 which was more frequently immunopositive in well-differentiated tumors than in poorly-differentiated tumors. There was no significant relation between bax expression and tumor differentiation. Our results suggest that alterations of bcl-2 and bax expression may occur as a relatively early event in cervical tumorigenesis. PMID:11198041

Aletra, C; Ravazoula, P; Scopa, C; Kounelis, S; Sotiropoulou, G; Kourounis, G; Ladopoulos, I; Bonikos, D

2000-01-01

99

Tumor volume and uterine body invasion assessed by MRI for prediction of outcome in cervical carcinoma treated with concurrent chemotherapy and radiotherapy  

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The aim of this study was to evaluate the prognostic significance of primary tumor volume and uterine body invasion assessed by pre-treatment MRI for uterine cervical cancer patient treated with concurrent chemotherapy and radiotherapy. A retrospective analysis of 106 patients with IB-IIIB cervical carcinoma was performed. Potential prognostic factors were stage, clinical tumor diameter, histology, age, pelvic lymph node, vaginal extension, parametrial invasion, tumor volume and uterine body invasion status. Multivariate analyses were performed to identify the prognostic factor for overall survival (OS) and disease-free survival (DFS). The 5-year OS, DFS rate were 59.7 and 56.6%. Using multivariate analyses, a large tumor volume (?30 ml; P=0.012) and uterine body invasion (P=0.020) and positive pelvic lymph node (LN) enlargement (P=0.040) showed a significantly unfavorable influence on OS. Using these three factors, patients were divided into four subgroups: the OS rates of patients with risk 0 (volume<30 ml, no uterine body invasion, and negative LN), risk 1 (one of these three factors), risk 2 (two of these three factors) and risk 3 (volume?30 ml, uterine body invasion, and positive LN) were 96.3, 77.5, 53.0 and 14.8%, respectively (P<0.0001). Tumor volume and uterine body invasion determined by MRI were significant prognostic factors for patients with cervical carcinoma. Pelvic lymph node enlargement diagnosed by CT also proved to be a significant prognostic faoved to be a significant prognostic factor in OS. Using these three parameters, we devised a practical and effective model to predict OS. (author)

100

Uterine Cancer Statistics  

Science.gov (United States)

... Research AMIGAS Fighting Cervical Cancer Worldwide Stay Informed Statistics for Other Kinds of Cancer Breast Cervical Colorectal ( ... Skin Vaginal and Vulvar Cancer Home Uterine Cancer Statistics Language: English Español (Spanish) Recommend on Facebook Tweet ...

101

Postmodern cancer: the role of human immunodeficiency virus in uterine cervical cancer.  

OpenAIRE

The association between cervical cancer and human papillomavirus (HPV) is well known, but its association with human immunodeficiency virus (HIV) is controversial. Coinfection with HPV and HIV is to be expected and recent epidemiological data from Africa show that cervical cancer is the most common AIDS defining neoplasm in women. Unlike other AIDS defining neoplasms, the occurrence of cervical cancer is not dependent on immune compromise. HIV alters the natural history of HPV infection, with...

Clarke, B.; Chetty, R.

2002-01-01

102

Expression of keratinocyte growth factor receptor (KGFR/FGFR2 IIIb) in human uterine cervical cancer.  

Science.gov (United States)

Keratinocyte growth factor receptor (KGFR), also known as FGFR2 IIIb, is a splice variant of FGFR-2. KGFR is expressed in many types of epithelial cell and is activated with four known ligands [FGF-1, FGF-3, FGF-7 (also known as KGF) and FGF-10] that are predominantly synthesized by mesenchymal cells. KGFR is highly expressed in the late-proliferative phase of a normal endometrium and in endometrial adenocarcinoma. In the present study, we attempted to determine the expression and localization of KGFR in human cervical cancer cell lines and cervical cancer tissues. The KGFR protein was detected in CaSki and HeLa cells, but not in ME-180 cells of cervical cancer cell lines. In non-cancer cervical tissues, KGFR immunoreactivity was weakly expressed in the surface of squamous epithelial cells and vascular smooth muscle cells. Immunohistochemically, the KGFR protein was detected in squamous cell carcinoma in 36 of 42 (86%) cervical cancer patients. In cervical cancer tissues, KGFR was detected in 17 of 18 (94%) of patients with the keratinizing type and 19 of 24 (79%) of patients with the non-keratinizing type of cervical cancer. Furthermore, KGFR was prominently localized in proliferating reserve cells and squamous metaplastic reserve cells adjacent to cancer cells. In contrast, KGFR was not detected in cervical ductal cells in cancer or non-cancer cervical tissues. These findings may indicate that KGFR mediates the growth and differentiation of reserve cells and squamous cell carcinoma in the cervix. PMID:15069536

Kurban, Gulnar; Ishiwata, Toshiyuki; Kudo, Mitsuhiro; Yokoyama, Munehiro; Sugisaki, Yuichi; Naito, Zenya

2004-05-01

103

High dose-rate brachytherapy for elderly patients with uterine cervical cancer  

International Nuclear Information System (INIS)

The need for radiotherapy (RT) in cancer treatment for the elderly patient is growing. The purpose of this study was to analyze the efficacy and complication rate for radiotherapy, using external-beam irradiation (EBRT) and high dose-rate intracavitary brachytherapy (HDRICB), for patients aged 70 years or older with carcinoma of the uterine cervix. From September 1992 to December 1997, 295 patients diagnosed with uterine cervical cancer completed RT at the Shin Kong Memorial Hospital and China Medical College Hospital. Two hundred and fifty-eight patients [International Federation of Gynecology and Obstetrics (FIGO) stage distribution: 35 Ib, 26 IIa, 122 IIb, 10 IIIa, 58 IIIb, 7 IVa] who had undergone at least two courses of HDRICB and a minimum of 3 years of follow-up, were evaluated. A retrospective analysis was conducted to compare the outcome of radiation therapy for the 179 patients under 70 years of age (younger group) and the 79 patients aged 70 years or older (older group). The RT consisted of EBRT followed by HDRICB. After a total EBRT dose of 40-45 Gy/20 in 25 fractions, irradiating the whole pelvis over 4-5 weeks, dosage for patients diagnosed as FIGO stage IIb-IVa bilateral parametrial disease was boosted to 54-58 Gy, with central shielding. HDRICB was administered at 1-week intervals using an Ir-192 remote after-loading technique. Ninety-nine patients (38.4%) received three fractions of HDRICB, while 156 patients (60.5%) had four fractions. Total prescrib(60.5%) had four fractions. Total prescribed Point A dosages (EBRT+HDRICB) ranged from 58 to 71.6 Gy (median, 65.6 Gy) for stage IB-IIA, while for larger lesions (stage IIB-IVA) analogous dosages were 59-75.6 Gy (median, 65.6 Gy). Median follow-up durations for the older and younger groups were 56/55 months, respectively. The respective 5-year actuarial survivals (AS) for the older and younger groups were 82/85% for stage Ib, 65/65% for IIa, 61/71% for IIb and 35/59% for IIIa-b. The 5-year cause-specific survivals (CSS) for the older and younger groups were 100/95% for stage Ib, 85/75% for IIa, 78/72% for IIb and 42/61% for IIIa-b. The 5-year pelvic relapse-free survivals (PRFS) for the older and younger groups were 100/100% for stage Ib, 91/93% for IIa, 91/90% for IIb and 67/80% for IIIa-b. The 5-year distant metastasis-free survivals (DMFS) for older and younger groups were 100/100% for stage Ib, 92/88% for IIa, 84/73% for IIb and 55/75% for IIIa-b. There was no statistically significant survival difference on comparing the two groups according to stage. The gross tumor-free ratios after EBRT (NRT) for the older and younger groups were 44.3/24.5% (P=0.001). The 5-year CSS for the 35 NRT patients was 88% for the older group, while for the 44 patients diagnosed with gross residual tumor after EBRT (GRT) it was 64% (P=0.001). Twelve (15.0%) of the 79 older patients and 14 (7.8%) of the 179 younger patients developed Radiation Therapy Oncology Group (RTOG) grade 3-4 rectal complications (P=0.12), while seven (8.9%) of the 79 older patients and 10 (5.6%) of the 179 younger patients developed RTOG grade 3-4 small bowel complications (P=0.34). Radiation therapy, consisting of a combination of EBRT and three or four fractions of HDRICB, proved to be effective for older patients. Further optimization of treatment policy is essential by changing the HDRICB fractionation strategy, shortening the treatment time and designing combination drug regimens that are both effective and tolerable during radiotherapy. (author)

104

Expression of Bmi-1, P16, and CD44v6 in Uterine Cervical Carcinoma and Its Clinical Significance  

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Full Text Available Objective: Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The p16 protein negatively regulated cell proliferation, whereas CD44v6 is associated with proliferation as an important protein. Additionally, CD44v6 is an important nuclear antigen closely correlated to tumor metastasis. The present study aims to investigate the expression and significance of Bmi-1, p16, and CD44v6 in uterine cervical carcinoma (UCC. Methods: A total of 62 UCC, 30 cervical neoplasic, and 20 normal cervical mucosal tissues were used in the current study. The expression of Bmi-1, p16, and CD44v6 in these tissues was determined using immunohistochemical assay. The relationships among the expression of these indices, the clinicopathologic features of UCC, and the survival rate of UCC patients were also discussed. The correlation between Bmi-1 protein expression and p16 or CD44v6 protein in UCC was analyzed. Results: The expression of Bmi-1, p16, and CD44v6 was significantly high in cervical carcinoma compared with that in the cervical neoplasia and normal colorectal mucosa (P0.05. The Kaplan–Meier survival analysis showed that the over-expression of Bmi-1 significantly decreased the survival rate of UCC patients (P<0.05. A strong correlation indicated that there was statistical significance between the expression of Bmi-1 and CD44V6 proteins in UCC (r=0.419, P=0.001. Conclusions: The over-expression of Bmi-1 and CD44v6 protein closely correlate to the tumorigenesis, metastasis, and prognosis of UCC. Bmi-1 and CD44v6 may be used to predict the prognosis of cervical carcinoma. Bmi-1 may indirectly regulate the expression of CD44v6 in UCC patients. The positive expression of p16 protein is possibly associated with the tumorigenesis, but not with the metastasis or prognosis of UCC.

Mei-ying Weng

2012-03-01

105

Cerebellar metastases in patients with uterine cervical cancer. Two cases reports and review of the literature; Metastases cerebelleuses chez des patientes atteintes d'un cancer du col uterin. A propos de deux cas et revue de la litterature  

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Brain metastases from cervical cancer are extremely rare. We report on two patients who developed cerebellar metastases following uterine cervical cancer. The interval between diagnosis of the primary cancer and diagnosis of brain metastasis was 8 months. The main complaint was symptoms of increased intracranial pressure and cerebellar syndrome. Surgical excision of the brain lesion followed by radiation therapy was performed in the first case. The second patient received palliative radiation therapy. The first patient died 8 months after diagnosis. The second patient is alive 2 months after diagnosis. (authors)

El Omari-Alaoui, H.; Gaye, P.M.; Kebdani, T.; El Ghazi, E.; Benjaafar, N.; Mansouri, A.; Errihani, H.; Kettani, F.; El Ouahabi, A.; El Gueddari, B.K. [Institut National d' Oncologie, Service de Radiotherapie, Rabat (Morocco)

2003-10-01

106

Uterine cervical melanoma presenting with rapid progression detected by PET/CT  

OpenAIRE

Malignant melanoma of the uterine cervix is a rare extracutaneous melanoma which develops aggressively and is associated with a bleak prognosis. To our knowledge, no prior published reports have discussed the role of 18F-FDG positron emission tomography/computed tomography (PET/CT) in managing this disease. Our case study involved a 66-year-old woman with a malignant melanoma of the uterine cervix. The patient received PET/CT that identified metastases and lesions which had not been detected ...

Tsai, Ya-ju; Shueng, Pei-wei; Chan, Sheng-chien; Chuang, Wen-yu; Shiau, Yu-chien; Hsu, Chung-huei

2012-01-01

107

Effects of radiotherapy combined with daily intramuscular injection of bleomycin for uterine cervical cancer  

International Nuclear Information System (INIS)

A total of 103 cases of cancer of the uterine cervix, untreated previously, were treated with radiotherapy combined with daily intramuscular injection of Bleomycin 30 minutes before irradiation (BR therapy) in 12 institutions. Result showed that especially in cases of stage III, BR therapy was superior in primary local control rate (89.6%), recurrence rate (20.8%) and crude 5-year survival rate (56.5%) to that of nationwide statistics. No severe side effects were found. It was concluded that external radiotherapy could control advanced cancers of uterine cervix combining with intramuscular injection of Bleomycin. (author)

108

Local lymphocytes and nitric oxide synthase in the uterine cervical stroma of patients with grade III cervical intraepithelial neoplasia  

Scientific Electronic Library Online (English)

Full Text Available OBJECTIVES: Precancerous and cancerous cells can trigger an immune response that may limit tumor development and can be used as a prognostic marker. The aims of the present study were to quantify the presence of B and T lymphocytes, macrophages and cells expressing inducible nitric oxide synthase (i [...] NOS) in the cervical stroma of women with grade III cervical intraepithelial neoplasia (CIN III) or in the intratumoral and peritumoral tissue of women with stage I invasive carcinoma. METHODS: Cervical tissue specimens were obtained from 60 women (20 each from control tissues, CIN III and invasive carcinomas). The average ages in the control, CIN III and invasive groups were 43.9 (± 4.3), 35.5 (± 9.5), and 50 (± 11.2) years, respectively. The specimens were immunohistochemically labeled with antibodies to identify T lymphocytes (CD3), cytotoxic lymphocytes (CD8), B lymphocytes (CD20), macrophages (CD68) and iNOS. We evaluated the markers in the stroma above the squamocolumnar junction (control), at the intraepithelial lesion (CIN cases), and in the nfiltrating tumor. Two independent observers performed the immunohistochemical analysis. RESULTS: T lymphocytes, B lymphocytes, macrophages and iNOS were present more frequently (P

Cléber Sergio da, Silva; Marcia Antoniazi, Michelin; Renata Margarida, Etchebehere; Sheila Jorge, Adad; Eddie Fernando Candido, Murta.

109

Apparent rarity of asymptomatic herpes cervicitis in a woman with intra-uterine contraceptive device  

OpenAIRE

Infection with genital herpes simplex virus (HSV) remains a common viral sexually transmitted disease, often subclinical and a major worldwide problem of women of reproductive age group. Herpes cervicitis is an unusual presentation of Herpes simplex virus infection in females. The finding of herpes cervicitis on routine pap smear of an asymptomatic woman on Intrauterine contraceptive device still further supports the need for increased awareness on the possibility of Herpes simplex virus infe...

Adeola Fowotade; Abu Clement Okolo; Mohammed Mohammed Manga; Chinenye Gloria Anaedobe; Ayodeji Akeem Salami; Effiong Essien Udo Akang

2013-01-01

110

Long-term outcomes of intracavitary hyperthermia in combination with radiotherapy for locally advanced uterine cervical cancer  

International Nuclear Information System (INIS)

Objective: To evaluate the long-term clinical efficacy and toxicities of combined intracavitary hyperthermia and radiotherapy for locally advanced uterine cervical cancer. Methods: 310 patients with locally advanced uterine cervical cancer were assigned into intracavitary hyperthermia + radiotherapy group(TRT, 181 patients) and external-beam radiotherapy + traditional intracavitary radiation group (RT,129 patients). The external-beam radiotherapy were given with 60Co ?-ray or 6-8 MV X-ray in traditional fractionation. In TRT group, radiotherapy was 40 Gy using the anterior-posterior pelvic fields and additional 20-25 Gy using the lateral fields. Hyperthermia was delivered by the 915 MHz microwave hyperthermia device within 15-60 min after external radiotherapy for 10-12 times(40 min each time, 1-2 times per week). The temperature of tumor surface was 46-47 degree C. In the RT group, the external-beam radiotherapy of 40 Gy was delivered using the anterior-posterior pelvic fields. The intracavity radiotherapy of radium was delivered before 1989, with 50 mg radium in the vagina and 30 mg in uterine cavity for 24 hours, weekly for 3 times to a total dose of 7200 mg·h. After 1989, intracavity radiotherapy of 192Ir was delivered to a total dose of 30-36 Gy to point A in 5-6 Gy fractions, 2 fractions per week. Results: The 5-year survival of patients in TRT group and RT group was 67.4% versus 52.1% for stage II disease (?2=7.55, P=0.006), disease (?2=7.55, P=0.006), and 60.0% versus 32.3% for stage III (?2=7.06, P=0.007). The 10-year survival was 46.5% versus 42.6% for stage II (?2=3.90, P=0.058), and 43.7% versus 20.6% for stage III (?2=17.28, P=0.000). Cox regression analysis showed that the tumor stage(P=0.023) and intracavitary hyperthermia (P=0.019) were prognostic factors. According to the RTOG criteria, the rate of mild to moderate late side effects of rectum and bladder in TRT and RT group was 17.7% and 33.1%, respectively (?2=9.18, P=0.002). Rectovaginal fistula was developed in 5 patients (3.9%) in RT group and 1 patient (0.6%) in TRT group (?2= 4.38,P=0.036). Conclusions: The long-term survival of patients with stage III uterine cervical cancer is better of TRT group than RT group. The TRT is well tolerated and the late toxicity rate is obviously low. it is necessary to carry out large randomized clinical trials to confirm these outcomes. (authors)

111

Local lymphocytes and nitric oxide synthase in the uterine cervical stroma of patients with grade III cervical intraepithelial neoplasia  

Directory of Open Access Journals (Sweden)

Full Text Available OBJECTIVES: Precancerous and cancerous cells can trigger an immune response that may limit tumor development and can be used as a prognostic marker. The aims of the present study were to quantify the presence of B and T lymphocytes, macrophages and cells expressing inducible nitric oxide synthase (iNOS in the cervical stroma of women with grade III cervical intraepithelial neoplasia (CIN III or in the intratumoral and peritumoral tissue of women with stage I invasive carcinoma. METHODS: Cervical tissue specimens were obtained from 60 women (20 each from control tissues, CIN III and invasive carcinomas. The average ages in the control, CIN III and invasive groups were 43.9 (± 4.3, 35.5 (± 9.5, and 50 (± 11.2 years, respectively. The specimens were immunohistochemically labeled with antibodies to identify T lymphocytes (CD3, cytotoxic lymphocytes (CD8, B lymphocytes (CD20, macrophages (CD68 and iNOS. We evaluated the markers in the stroma above the squamocolumnar junction (control, at the intraepithelial lesion (CIN cases, and in the nfiltrating tumor. Two independent observers performed the immunohistochemical analysis. RESULTS: T lymphocytes, B lymphocytes, macrophages and iNOS were present more frequently (P<0.05 in the stroma of peritumoral invasive tumors compared to the controls and intratumoral invasive cancer samples. CD3+ and CD20+ lymphocytes were present more frequently in CIN III patients compared to samples from patients with intratumoral invasive cancer (P<0.05. CONCLUSION: High numbers of T and B lymphocytes, macrophages and iNOS-expressing cells in the peritumoral stroma of the invasive tumors were observed. Cell migration appeared to be proportional to the progression of the lesion.

Cléber Sergio da Silva

2010-01-01

112

Expression of the inhibitor of DNA-binding (ID)-1 protein as an angiogenic mediator in tumour advancement of uterine cervical cancers  

OpenAIRE

The ID protein, an inhibitor of basic helix-loop-helix (HLH) transcription factors, has been involved in multiple cellular processes. To investigate the association between tumour advancement and ID expressions of uterine cervical cancers, the levels of ID-1, ID-2 and ID-3 mRNAs were determined by real-time reverse transcription-polymerase chain reaction and the histoscore with the localisation of ID-1 was determined by immunohistochemistry and patient survival in 60 patients. ID-1 histoscore...

Maw, M. K.; Fujimoto, J.; Tamaya, T.

2009-01-01

113

Metastatic cervical lymphadenopathy from uterine leiomyosarcoma with good local response to radiotherapy and chemotherapy  

International Nuclear Information System (INIS)

The metastasis of uterine leiomyosarcoma to the neck node has not been reported previously and the radiotherapy has been rarely used for the metastatic lesion of the other sites. We report a case of neck metastasis from a uterine leiomyosarcoma, which developed 10 months after surgery and postoperative pelvic radiotherapy. It also involved the parapharyngeal space, adjacent spine, and spinal canal. The metastatic neck mass was inoperable, and was treated by neck radiotherapy (6,000 cGy) and chemotherapy including taxol and carboplatin. The mass has regressed progressively to a nearly impalpable state. She has never developed spinal cord compression syndrome, and has maintained good swallowing for eight months since the neck radiotherapy and chemotherapy. Since the extensive metastatic neck mass showed good local response to high dose radiotherapy and chemotherapy, both treatments may be considered for an unresectable metastatic leiomyosarcoma

114

Metastatic cervical lymphadenopathy from uterine leiomyosarcoma with good local response to radiotherapy and chemotherapy  

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The metastasis of uterine leiomyosarcoma to the neck node has not been reported previously and the radiotherapy has been rarely used for the metastatic lesion of the other sites. We report a case of neck metastasis from a uterine leiomyosarcoma, which developed 10 months after surgery and postoperative pelvic radiotherapy. It also involved the parapharyngeal space, adjacent spine, and spinal canal. The metastatic neck mass was inoperable, and was treated by neck radiotherapy (6,000 cGy) and chemotherapy including taxol and carboplatin. The mass has regressed progressively to a nearly impalpable state. She has never developed spinal cord compression syndrome, and has maintained good swallowing for eight months since the neck radiotherapy and chemotherapy. Since the extensive metastatic neck mass showed good local response to high dose radiotherapy and chemotherapy, both treatments may be considered for an unresectable metastatic leiomyosarcoma.

Oh, Yoon Kyeong; Park, Hee Chul; Kee, Keun Hong; Jeon, Ho Jong; Park, You Hwan; Chung, Choon Hai [College of Medicine, Chosun Univ., Kwangju (Korea, Republic of)

2000-12-01

115

Genomic amplification of the human telomerase gene (hTERC associated with human papillomavirus is related to the progression of uterine cervical dysplasia to invasive cancer  

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Full Text Available Abstract Background Human papillomavirus (HPV infection plays an etiological role in the development of cervical dysplasia and cancer. Amplification of human telomerase gene (hTERC and over expression of telomerase were found to be associated with cervical tumorigenesis. This study was performed to analyze genomic amplification of hTERC gene, telomerase activity in association with HPV infection in different stages of cervical intraepithelial neoplasia (CIN and cervical cancer. We were studying the role of hTERC in the progression of uterine cervical dysplasia to invasive cancer, and proposed an adjunct method for cervical cancer screening. Methods Exfoliated cervical cells were collected from 114 patients with non neoplastic lesion (NNL, n=27, cervical intraepithelial neoplasia (CIN1, n=26, CIN2, n=16, CIN3, n=24 and cervical carcinoma (CA, n=21, and analyzed for amplification of hTERC with two-color fluorescence in situ hybridization (FISH probe and HPV-DNA with Hybrid Capture 2. From these patients, 53 were taken biopsy to analyze telomerase activity by telomeric repeat amplification protocol (TRAP and expression of human telomerase reverse transcriptase (hTERT, with immunohistochemistry (IHC. All biopsies were clinically confirmed by phathologists. Results Amplification of hTERC was significantly associated with the histologic diagnoses (p Conclusions hTERC ampliffication can be detected with FISH technique on exfoliated cervical cells. Amplification of hTERC and HPV infection are associated with more progressive CIN3 and CA. The testing of hTERC amplification might be a supplementary to cytology screening and HPV test, especially high-risk patients. Virtual slides The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1857134686755648.

Liu Hongqian

2012-10-01

116

Apparent rarity of asymptomatic herpes cervicitis in a woman with intra-uterine contraceptive device  

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Full Text Available Infection with genital herpes simplex virus (HSV remains a common viral sexually transmitted disease, often subclinical and a major worldwide problem of women of reproductive age group. Herpes cervicitis is an unusual presentation of Herpes simplex virus infection in females. The finding of herpes cervicitis on routine pap smear of an asymptomatic woman on Intrauterine contraceptive device still further supports the need for increased awareness on the possibility of Herpes simplex virus infection among women, particularly those on Intrauterine contraceptive device. The index case is a 28 years old Nigerian female who was referred to our Special Treatment Clinic on account of an abnormal pap smear cytology which was in keeping with Herpes cervicitis. There was no history of genital ulcer in this patient; however ELISA for HSV 2 IgM was positive in her. We therefore describe a case of herpes cervicitis in an asymptomatic woman on intrauterine contraceptive device. This case highlights to clinicians the need to be aware of the possibility of this association and to carry out relevant investigations so as to identify and treat these patients appropriately. Therefore, there is a need to put in place adequate public health intervention strategy to prevent genital herpes in women of reproductive age group with a view to preventing the possibility of congenital herpes in subsequent pregnancy.

Adeola Fowotade

2013-12-01

117

Chemotherapy in locally advanced cervical cancers; Chimioradiotherapie dans les cancers du col uterin localement evolues  

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The authors report a retrospective analysis of data and results obtained in Morocco in the treatment of 130 locally advanced cervical cancers from January 2005 to June 2008. A majority of patients were treated by chemotherapy in combination with an external radiotherapy. The prognostic remains unfavourable. Short communication

Elkholti, Y.; Rida, H.; Sadek, H.; Erraisse, M.A.; Derhem, N.; Benhmidoune, M.A.; Elomrani, A.; Khouchani, M.; Tahri, A. [service de radiotherapie, CHU Mohammed-VI, Marrakech (Morocco)

2010-10-15

118

A study for diagnosis of uterine cervical carcinoma with squamous cell carcinoma antibody  

International Nuclear Information System (INIS)

In the past few decades, the presence of tumor-associated antigens has been demonstrated for several human neoplasms. In addition, recent developments in methods of radioimmunoassay have made it possible to detect low antigenic activity. The SCC demonstrated by Kato et al. has been reported to be specific for cervical squamous cell carcinoma. In addition, serial determinations of SCC may provide a useful method for evaluating regression or progression of disease. Another value of SCC in predicting the extent and prognosis has been suggested. From May, 1985. to July 1985. the SCC test were performed in 27 patients with histologically proven diagnosis. And changes of antigenic activities according to the chemotherapy were check only in 2 cases. Results are as follows: 1. 9 of 13 patients(69.2) with cervical squamous cell carcinoma showed positivity. 2. None of 6 control group without malignancy showed positivity. 3. Only three of eight patient with squamous cell carcinoma but cervical squamous cell carcinoma (37.5%) showed negativity. 4. Among the 13 patients with cervical squamous cell carcinoma, 2 of 4 patients with CIS(50%) were positive, 2 of 2 stage II patients(100%) were positive, 4 of 4 stage III or IV patients(100%) were positive and 1 of 3 recurrent cervical carcinoma patients(33.3%) was positive. The means of SCC antigen activities were 1.8 ng/ml, 20.5 ng/ml, 40.8 ng/ml, and 6.0 ng/ml, respectively. 5. 2 of 5 patients with bronchogenic carcinoma (40%) were poswith bronchogenic carcinoma (40%) were positive, 2 patients with vaginal carcinoma(100%) were both positive, 1 patients with right ovarian tumor was positive. The means of SCC antigen activities were 2.8 ng/ml, 7.1 ng/ml and 4.9 ng/ml, respectively. 6. 2 patients(cervical carcinoma patient and vaginal carcinoma patient) were checked repeatedly according to chemotherapy. The titer of the patient with cervical carcinoma was decreased from 4.1 ng/ml to 1.9 ng/ml and that of the patient with vaginal carcinoma was also decreased from 6.1 ng/ml to 1.1 ng/ml. (Author)

119

Clinical study on protective of glutathione from radiation injuries in uterine cervical cancer  

International Nuclear Information System (INIS)

The protective effects of glutathione (GSH) against radiation were studied by the single, blind method in patients with carcinoma of the uterine cervix treated by radiotherapy. The background factors were same in the GSH group as in the control group. The results revealed that the occurrence of abnormal values of WBC, PLT, GOT, GPT and hematocrit in the GSH group were significantly lower than those in the control group by signed rank test, which suggests a possibility that GSH prevents these blood findings from becoming abnormal. In subjective or objective symptoms, the appearance of general lassitude was significantly reduced in the GSH group. Blood findings were studied in relation to NSD. (auth.)

120

Human Papillomavirus Types 52 and 58 Are Prevalent in Uterine Cervical Squamous Lesions from Japanese Women  

OpenAIRE

Objective. To estimate the prevalence and genotypes of high-risk human papillomavirus (HPV) focusing HPV 16, 18, 52, and 58 in Japan. Methods. Liquid-base cytology specimens were collected from Japanese women (n = 11022), aged 14–98. After classifying cytodiagnosis, specimens were analyzed for HPV DNA by the multiplex polymerase chain reaction method, where 1195 specimens were positive for cervical smear, except adenomatous lesions. Result. HPV genotypes were detected in 9.5% of NILM and 72...

Morie Nishiwaki; Tomoya Mizunoe; Yosuke Kawakami; Junichi Sakane; Toshinao Nishimura; Tamaki Toda; Kazuhiro Takehara; Kiyomi Taniyama

2011-01-01

121

Optimal overall treatment time in fractionated radiotherapy for head and neck cancers, esophageal cancer, and uterine cervical cancer  

International Nuclear Information System (INIS)

The effects of overall treatment time (OTT) on local control of radiation therapy (RT) were evaluated to consider optimal OTT in RT. Local control probabilities and acute and late toxicities of esophageal cancer (Stages I-III), glottic laryngeal cancer (Stage I), and uterine cervical cancer (Stage III) treated at Kyoto University Hospital and its affiliated hospitals were analyzed in relation to OTT. For these tumors, local control probabilities decreased when OTT increased. In the multivariate analyses for esophageal cancer and laryngeal cancer, OTT was a significant variable for local control. Only a 1-week interruption of RT due to holidays resulted in a significant reduction of local control probability for T1 glottic tumors. On the other hand, there was no significant difference in local control rates between OTT of 4 weeks and 6 weeks for esophageal cancer. For complications, acute and late toxicities increased when OTT was reduced by accelerated hyperfractionated RT for esophageal cancer. In conclusion, OTT should be kept as short as possible within the limits of tolerance of normal tissues and the patients. We consider that RT must be delivered in the range of 66 to 70 Gy in 6 weeks to obtain optimal local control with minimum complications. (author). 52 refs

122

Dose optimization of fractionated external radiation and high-dose-rate intracavitary brachytherapy for FIGO stage IB uterine cervical carcinoma  

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Purpose: To determine the optimal dose combination scheme of external beam radiotherapy (EBRT) and high-dose-rate (HDR) intracavitary radiation (ICR) for maximizing tumor control while conferring an acceptable late complication rate in the treatment of Stage IB uterine cervical cancer. Methods and Materials: We retrospectively analyzed 162 patients with International Federation of Gynecology and Obstetrics (FIGO) Stage IB squamous cell carcinoma of the uterine cervix who received definitive RT between May 1979 and December 1990. Before HDR-ICR, all patients received EBRT to a total dose of 40-46 Gy (median 45), administered during 4-5 weeks to the whole pelvis. HDR-ICR was given 3 times weeks to a total dose of 24-51 Gy (median 39) at point A, using a dose of 3 Gy/fraction. Central shielding from EBRT was begun after the delivery using 20-45 Gy (median 40) of the external dose. The total dose to point A, calculated by adding the EBRT biologically effective dose (BED) and the ICR BED to point A, was 74.1-118.1 Gy (mean 95.2). The rectal point dose was calculated at the anterior rectal wall at the level of the cervical os. The local control rate, survival rate, and late complication rate were analyzed according to the irradiation dose and BED. Results: The initial complete response rate was 99.4%. The overall 5-year survival rate and 5-year disease-free survival rate was 91.1% and 90.9%, respectively. The local failure rate was 4.9%, and the distant failure rate was 4.34.9%, and the distant failure rate was 4.3%. Late complications were mild and occurred in 23.5% of patients, with 18.5% presenting with rectal complications and 4.9% with bladder complications. The mean rectal BED (the sum of the external midline BED and the ICR rectal point BED) was lower in the patients without rectal complications than in those with rectal complications (125.6 Gy vs. 142.7 Gy, p=0.3210). The late rectal complication rate increased when the sum of the external midline BED and the rectal BED by ICR was ?131 Gy (p=0.1962). However, 5-year survival rates did not increase with the external midline BED (p=0.4093). The late rectal complication rate also increased, without a change in the survival rate, when the sum of the external midline BED and the ICR point A BED was >90 Gy. Conclusion: In treating Stage IB carcinoma of the uterine cervix with HDR-ICR, using fractions of 3 Gy, it is crucial to keep the point A BED at ?90 Gy to minimize late rectal complications without compromising the survival rate. To achieve this goal, appropriate central shielding from EBRT is needed

123

A study on nucleic acid synthesis and nuclear chromatin of uterine cervical carcinoma  

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1. Specimens from cervical carcinoma taken prior to radiotherapy showed mean labeling index of 29.9% for 3H-TdR and 63.4% for 3H-UdR, indicating that small cell undifferntiated type carcinoma have relatively prominent activity of nucleic acid synthesis as compared to large cell non-keratinizing or keratinizing type carcinoma. 2. Even with biopsy specimens, chromatin patterns of most unirradiated tumors were predominantly of active type whereas tumors in which degenerative patterns of chromatin predominated were only rarely encountered. Active chromatin patterns were frequently conspicuous in small cell undifferentiated type carcinoma. 3. Both the 3H-TdR and 3H-UdR labeling index of cervical carcinoma decreased following irradiation, the diminution of the former being progressively greater with increasing cumulative dosis of radiation. Small cell undifferentiated type carcinoma showed a more marked diminution of the labeling index than large cell type carcinomas. 4. Degenerative patterns of chromatin increased progressively to become predominant over active patterns, with increasing dose of radiation. This shift to predominance of degenerative patterns was more conspicuous in small cell undifferentiated type carcinoma than in large cell type carcinomas. 5. There was a noticeably close interrelation between the nucleic acid synthesis and the chromatin pattern of cervical carcinoma cells before as well as after irradiation. Hows before as well as after irradiation. However, the tumor cell responses to radiation appeared to show a slight time lag between the morphologic aspect, or nucleic acid synthesis, and the morphologic aspect, or chromatin patterns, the former preceding the latter. (J.P.N.)

124

Central cervical fibroid mimicking as chronic uterine inversion: a case report  

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Full Text Available Leiomyomas are most common benign gynaecological tumor. Most of the fibroids are situated in the body of the uterus, but only in 1-2% cases, they are confined to cervix. We report a case of 33 years old women, para 2 live 2 diagnosed as myomatous polyp on ultrasound and clinically as chronic inversion of uterus. On surgery, we found it as central cervical fibroid with uterus sitting on the fibroid i.e. lantern on the St. Paul?s. [Int J Reprod Contracept Obstet Gynecol 2013; 2(4.000: 687-688

Swati Singh

2013-08-01

125

Uterine Sarcoidosis: A Rare Extrapulmonary Site of Sarcoidosis  

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Sarcoidosis is a multisystem disease which is most commonly manifested in the pulmonary system. However, extrapulmonary manifestations have also been frequently reported. Isolated occurrence of sarcoidosis in the genital system is rare and poses a diagnostic and therapeutic dilemma. Uterine sarcoidosis can present with cervical erosions, endometrial polypoid lesions, and recurrent serometra. In majority of cases, it is diagnosed by endometrial curettage, but it has also been detected by exami...

Marak, Creticus P.; Narendrakumar Alappan; Amit Chopra; Olena Dorokhova; Sumita Sinha; Guddati, Achuta K.

2013-01-01

126

Early determination of uterine cervical squamous cell carcinoma radioresponse identifies high- and low-response tumors  

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Purpose: To investigate whether early-assessed radioresponse of tumors corresponds with late-assessed radioresponse, which is associated with local disease control in radiotherapy (RT) for cervical cancer. Methods and Materials: This prospective study included 12 patients with cervical squamous cell carcinoma treated by RT with or without concurrent cisplatin. Tumor volume was estimated by scheduled magnetic resonance imaging before (preRT), 3 to 4 weeks after (early assessment), and 6 to 7 weeks after (late assessment) RT initiation. Radioresponse was assessed with tumor shrinkage curves based on these volumes. Radioresponse for each tumor was calculated as the slope (day-1) of the shrinkage curve by fitting to an exponential equation. Results: Early-assessed radioresponse ranged from 0.001 to 0.106 day-1 (median, 0.021 day-1) and late-assessed radioresponse from 0.009 to 0.091 day-1 (median, 0.021 day-1), with no significant difference between them (p = 0.1191). The early-assessed radioresponse correlated with the late-assessed radioresponse (R 2 = 0.714, p = 0.0005). Conclusions: Correspondence between early- and late-assessed radioresponse in a series of tumors showing a wide range of radioresponse was not particularly close overall. However, early assessment of radioresponsiveness did seem to be useful for characterizing those tumors with high or low radioresponsivenessesponsiveness

127

Cytotoxic effect and radiation enhancement of artemisinin in uterine cervical carcinoma cell line HeLa  

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Objective: To investigate cytotoxic and radiosensitizing effect of Artemisinin on cervical carcinoma cell line HeLa. Methods: In order to measure the optimized effective time, cytotoxic effect of Artemisinin on HeLa cell line was investigated with MTT assay. The radiosensitization effect of different doses and different treatment duration of Artemisinin on HeLa cell line were evaluated by MTT test, the SER is 1.17 and radiosensitizing effect was measured with multi-target single hit model through SER of HeLa cell. Cell cycles in different groups were calculated by flow cytometry. Results: The 50% inhibition concentration of Artemisinin interacted with HeLa cells for 24 h is 600.19 nmol/ml, and for 48 h is 160.71 nmol/ml. The HeLa cells'surival ratio is 93.51%, 91.87%, and 87.28% after adding Atemisinin of 110.69 nmol/ml and 1 Gy radiation exposure. There are three groups: the chemotherapy only group, the radiotherapy only group and the combination group. The result of the cell cycles showed that cells in G2/M period decreased in the combination group. Conclusion: Artemisinin has radiosensitization effect on cervical carcinoma HeLa cells, whichshows dose and time dependent. Artemisinin can inhibit the G2/M block by ionizing radiation. (authors)

128

Knowledge, attitudes and practices on cervical cytology-uterine in women from sincelejo and Cartagena, colombia  

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Full Text Available Although in Colombia screening programs of cervical cancer have achieved high levelsof coverage, cervical cancer has the first places in incidence and mortality. There isthe need to identify factors influencing it, among them is to investigate the level ofawareness of women about the screening test, their attitudes to screening and itspractices. For this we made a survey of 505 women 13 to 60 years who have had sexual life, living in the cities of Cartagena and Sincelejo (Colombia.The results showthat virtually all women have knowledge of cervical cytology, 94.5% of women havemade at least once. This percentage is higher in the range of 40 to 60 years where itreaches 99% in younger women this percentage decrease. In defining its usefulness,only 73.8% responded accurately. 50% reported unpleasant aspects related to themaking of the cytology, such as fear, and fear of a cancer diagnosis. A fail to rememberis the main factor for not claiming the results.These data show that the percentage ofwomen with sexual life that ignores the usefulness of cytology or never have practicedis minimal, which leads to the conclusion that ineffective screening programs to reducecervical cancer rates depends on other factors that should be investigated.RESUMEN:Aunque en Colombia los programas de prevención del cáncer de cérvix han alcanzadoaltos niveles de cobertura, todavía este ocupa los primeros lugares en incidencia ymortalidad. Existe la necesidad de identificar los factores que influyen en ello, por tantoes importante investigar el nivel de conocimiento de las mujeres sobre la prueba detamizaje, su actitud frente a la misma y sus prácticas relacionadas. Se realizó encuestaa 505 mujeres entre 13 y 60 años edad, que habían tenido vida sexual, residentes en lasciudades de Cartagena y Sincelejo (Colombia. Los resultados revelan que prácticamentetodas las mujeres tienen conocimientos sobre citología cérvico-uterina. El 94.5% delas mujeres se la han realizado por lo menos una vez. Este porcentaje es mayor en elrango de 40 a 60 años donde alcanza el 99%, y en las de menor edad este porcentajedisminuye. Al definir su utilidad: solo el 73.8% respondió de manera acertada. El 50%refieren aspectos desagradables en relación con la toma de la citología, como el miedoy el temor a un diagnóstico de cáncer y el olvido es el principal factor para no reclamarlos resultados. Estos datos demuestran que el porcentaje de mujeres con vida sexualque desconocen la utilidad de la citología o nunca se la han practicado es mínimo, locual permite concluir que la ineficacia de los programas de tamizaje para disminuir lascifras de cáncer de cérvix en nuestro medio depende de otros factores que deben serevaluados.

Barrrios-Garcia Lia

2011-12-01

129

Effects of conformation radiotherapy combined with daily intramuscular injection of bleomycin for uterine cervical cancer  

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During the period 1970-1978, 112 fresh cervical cancer patients were treated with conformation radiotherapy (60Co ?-ray). Since 1973, 2mg of Bleomycin was injected intramuscularly about 30 minutes before the irradiation in 30 cases of them (i.e. BR-therapy). The comparative prognosis for each treatment method was investigated and the following results were obtained. 1) In Stage II and III cases the incidence of the local recurrence was reduced from 32.6% with conformation radiotherapy alone to 16.7% by BR-therapy. 2) The 5 year crude survival rate for Stage III patients was 31.8% in the former group and 50.0% in the latter group. This evidence supports the view that BR-therapy is an effective treatment for the carcinoma of the cervix. (author)

130

RAPIDARC (RA) in the uterine cervical cancer; dosimetric gain vs 3D-Crt  

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This work aims to quantitatively assess RAPIDARC (RA) treatments versus three dimensional-Conformal Radiation Therapy with field to field technique (3D-Crt-Fin F). 11 patients with cervical cancer treated at our institution radically or adjuvant clinical stages I-III B were evaluated. The prescribed dose was 50 Gy (2 Gy / Fr). The RA plans consisted of two isocentric complete arcs and conformational plans of 4 isocentric fields (previous, subsequent, right side and left side) with 3D-Crt-Fin F technique; both cases carried out ??in the Eclipse version 10 planner with calculation algorithm analytical anisotropic algorithm (AAA) and volumetric optimization software (for VMAT plans). Homogeneity indices (Hi), conformity indices (CI) Sigma indices (S-Index), monitor units (MU) and the time required for each treatment were compared. The mean age was 52 years (32-65) of the 11 patients 9 were clinical stages I-II B. The Hi varied from 0.052 for RA to 0.163 for 3D-Crt-Fin F (p = 0.009), and the CI between 1.005 and 1.35 (p = 0.26), the S-index from 1.2 to 3.7 (p = 0.001) and the H-index of 1.08 to 1.15 (p = 0.24). All dose limits in risk organs were met with a significant difference in the RA plans versus 3D-Crt-Fin F. In patients with cervical cancer the treatment plans quality with the indices aforementioned seems to be better with the RA technique, being observed a significant reduction of radiation to surrounding organs. (author)

131

Pre-treatment diffusion-weighted MR imaging for predicting tumor recurrence in uterine cervical cancer treated with concurrent chemoradiation: Value of histogram analysis of apparent diffusion coefficients  

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To evaluate the value of apparent diffusion coefficient (ADC) histogram analysis for predicting tumor recurrence in patients with uterine cervical cancer treated with chemoradiation therapy (CRT). Our institutional review board approved this retrospective study and waived informed consent from each patient. Forty-two patients (mean age, 56 ± 14 years) with biopsy-proven uterine cervical squamous cell carcinoma who underwent both pre-treatment pelvic magnetic resonance imaging with a 3.0 T magnetic resonance scanner and concurrent CRT were included. All patients were followed-up for more than 6 months (mean, 36.4 ± 11.9 months; range 9.0-52.8 months) after completion of CRT. Baseline ADC parameters (mean ADC, 25th percentile, 50th percentile, and 75th percentile ADC values) of tumors were calculated and compared between the recurrence and no recurrence groups. In the recurrence group, the mean ADC and 75th percentile ADC values of tumors were significantly higher than those of the no recurrence group (p = 0.043 and p = 0.008, respectively). In multivariate analysis, the 75th percentile ADC value of tumors was a significant predictor for tumor recurrence (p = 0.009; hazard ratio, 1.319). When the cut-off value of the 75th percentile ADC (0.936 x 10{sup -3} mm{sup 2}/sec) was used, the overall recurrence free survival rate above the cut-off value was significantly lower than that below the cut-off value (51.9% vs. 91.7%, p = 0.003, log-rank test). Pre-CRT ADC histogram analysis may serve as a biomarker for predicting tumor recurrence in patients with uterine cervical cancer treated with CRT.

Heo, Suk Hee; Kim, Jin Woong; Lim, Hyo Soon; Jeong, Yong Yeon; Kang, Woo Dae; KIm, Seok Mo; Kang, Heong Keun [Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun (Korea, Republic of); Shin, Sang Soo [Chonnam National University Hospital, Chonnam National University Medical School, Gwangju (Korea, Republic of)

2013-08-15

132

Image-Guided Stereotactic Body Radiation Therapy in Patients With Isolated Para-Aortic Lymph Node Metastases From Uterine Cervical and Corpus Cancer  

International Nuclear Information System (INIS)

Purpose: The aims of this study were to evaluate the role of stereotactic body radiation therapy (SBRT) as a local treatment for isolated para-aortic lymph node (PALN) metastases originating from uterine cervical and corpus cancer. Methods and Materials: We retrospectively enrolled 30 patients with isolated PALN metastases originating from uterine cervical and corpus cancer who had received SBRT using the CyberKnife (CK). All patients were shown to have isolated PALN metastases by computed tomography (CT) and/or positron emission tomography (PET)-CT. The overall survival (OS), local control (LC) rate, and disease progression-free survival (DPFS) rate were calculated according to the Kaplan-Meier method. Comparison between prognosis groups was performed using log-rank analysis. Toxicities were also evaluated. Results: The 4-year OS rate was 50.1%, and the median survival time was not reached. The OS rate among symptomatic patients was significantly lower than that among asymptomatic patients (p = 0.002). The 4-year actuarial LC rate was 67.4%. Patients with a planning target volume of ?17 ml had significantly higher LC rates (p = 0.009). The 4-year DPFS rate was 45.0%, and the median time to disease progression was 32 months. Small planning target volume was a favorable prognostic factor (p = 0.043). Grade 3 or 4 complications requiring hospitalization were reported in 1 patient at 20 months after SBRT. Conclusion: The OS and LS rates were promising, and the incidencS rates were promising, and the incidence of toxicities was low. Use of SBRT with the CyberKnife is an effective modality for treating isolated PALN metastases in patients with uterine cervical and corpus cancer.

133

Preoperative PET/CT FDG standardized uptake value of pelvic lymph nodes as a significant prognostic factor in patients with uterine cervical cancer  

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Using integrated PET/CT, we evaluated the prognostic relevance in uterine cervical cancer of preoperative pelvic lymph node (LN) [18F]FDG uptake. Patients with FIGO stage IB to IIA uterine cervical cancer were imaged with FDG PET/CT before radical surgery. We used Cox proportional hazards regression to examine the relationship between recurrence and the FDG maximum standardized uptake value (SUVmax) in the pelvic LN (SUVLN) on PET/CT. Clinical data, treatment modalities, and results in 130 eligible patients were reviewed. The median postsurgical follow-up was 34 months (range 6 to 109 months). Receiver operating characteristic analysis identified SUVLN 2.36 as the most significant cut-off value for predicting recurrence. SUVLN was correlated with SUVtumour (P = 0.002), primary tumour size (P = 0.004), and parametrial invasion (P = 0.013). Univariate analyses showed significant associations between recurrence and SUVLN (P = 0.001), SUVtumour (P = 0.007), pelvic LN metastasis (P = 0.002), parametrial invasion (P LN (P = 0.013, hazard ratio, HR, 4.447, 95 % confidence interval, CI, 1.379 - 14.343) and parametrial invasion (P = 0.013, HR 6.728, 95 % CI 1.497 - 30.235) as independent risk factors for recurrence. Patients with SUVLN ?2.36 and SUVLN <2.36 differed significantly in terms of recurrence (HR 15.20, P < 0.001). Preoperative pelvic LN FDG uptake showed a strong significant association with uterine cervical cancer recurrence. (orig.)

134

Inappropriate cervical injection of radiotracer for sentinel node mapping in a uterine cervix cancer patient: importance of lymphoscintigraphy and blue dye injection  

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Full Text Available Herein, we report a case of sentinel lymph node mapping in a uterine cervix cancer patient, referring to the nuclear medicine department of our institute. Lymphoscintigraphy images showed inappropriate intra?cervical injection of radiotracer. Blue dye technique was applied for sentinel lymph node mapping, using intra?cervical injection of methylene blue. Two blue/cold sentinel lymph nodes, with no pathological involvement, were intra?operatively identified, and the patient was spared pelvic lymph node dissection. The present case underscores the importance of lymphoscintigraphy imaging in sentinel lymph node mapping and demonstrates the added value of blue dye injection in selected patients. It is suggested that preoperative lymphoscintigraphy imaging be considered as an integral part of sentinel lymph node mapping in surgical oncology. Detailed results of lymphoscintigraphy images should be provided for surgeons prior to surgery, and in case the sentinel lymph nodes are not visualized, use of blue dye for sentinel node mapping should be encouraged.

Sima Kadkhodayan

2014-10-01

135

Gastrointestinal tract complications following radiotherapy of uterine cervical cancer: past and present  

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A retrospective analysis of the gastrointestinal tract complications in 298 patients with cervical cancer treated with radiotherapy at the State University of New York at Buffalo and Albert Einstein College of Medicine affiliated hospitals was carried out. Fifty-two patients had pretreatment surgical staging (39 transperitoneal and 13 extraperitoneal). Twenty-four percent had varying degrees of radiation sickness. They all responded to conservative therapy. Seven percent developed Stage I radiation proctitis. In the clinical staging group late complications consisted of: Three small bowel injuries, 4% persistent Stage I, 3% Stage III, and one patient with Stage II radiation proctitis. Among 39 patients who had transperitoneal surgical staging, two small bowel injuries, one case of gastric ulcer, and three cases of radiation proctitis were encountered. Only one of 13 patients who had extraperitoneal surgical staging developed intestino-vesico-vaginal fistula. A literature search was conducted, and prophylactic and therapeutic measures are discussed. The importance of careful selection of patients for radiotherapy and recognition of high risk clinical factors is reemphasized.

Yoonessi, M.; Romney, S.; Dayem, H.

1981-01-01

136

Gastrointestinal tract complications following radiotherapy of uterine cervical cancer: past and present  

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A retrospective analysis of the gastrointestinal tract complications in 298 patients with cervical cancer treated with radiotherapy at the State University of New York at Buffalo and Albert Einstein College of Medicine affiliated hospitals was carried out. Fifty-two patients had pretreatment surgical staging (39 transperitoneal and 13 extraperitoneal). Twenty-four percent had varying degrees of radiation sickness. They all responded to conservative therapy. Seven percent developed Stage I radiation proctitis. In the clinical staging group late complications consisted of: Three small bowel injuries, 4% persistent Stage I, 3% Stage III, and one patient with Stage II radiation proctitis. Among 39 patients who had transperitoneal surgical staging, two small bowel injuries, one case of gastric ulcer, and three cases of radiation proctitis were encountered. Only one of 13 patients who had extraperitoneal surgical staging developed intestino-vesico-vaginal fistula. A literature search was conducted, and prophylactic and therapeutic measures are discussed. The importance of careful selection of patients for radiotherapy and recognition of high risk clinical factors is reemphasized.

Yoonessi, M.; Romney, S.; Dayem, H.

1981-10-01

137

Multi-purpose horizontal transit table for influential factors in dose distribution of brachytherapy in moderately advanced and advanced uterine cervical cancer  

International Nuclear Information System (INIS)

Objective: The factors influencing the dose distribution of intracavitary brachytherapy for moderately advanced and advanced uterine cervical cancer was studied. Methods: Ninty-five patients with cervical cancer II-III b who received radical radiation therapy in our department from Aug, 2004 to Nov,2005, were treated with after-loading brachytherapy using, first, the self-designed 'Mutipurpose Horizontal Transit Table (MPHTT) for locating and treatment before the intracavitary brachytherapy proper. The deviation of isodose curve based on A-B reference system, and the dose of deviation was defined by measuring in a practical standard phantom. Results: There were significant influence on the deviation of isodose curve in pathology and para-metrial infiltration of cervical cancer and operating skill, but negative to clinical stage. The degree of deviation of isodose curve could not be lowered with the increase in sessions of' intracavitary brachytherapy. Conclusions: It is necessary to perform the locating, by use of mphtt, before the proper brachytherapy for patients with cervical cancer, not only for the identification of the deviation of isodose curve, but also to provide the evidence for revising the plan for dose adjustment of conformal radiation therapy in the pelvic cavity. (authors)

138

Vírus HPV e câncer de colo de útero / Human Papillomavirus (HPV) and uterine cervical cancer / Virus HPV y el cáncer del cuello uterino  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Este artigo refere-se a uma revisão de literatura sobre o vírus HPV e câncer de colo de útero, com o objetivo de levantar aspectos da infecção do vírus que influenciam no curso natural do câncer de colo de útero tais como: a tipologia do vírus, a duração e a persistência da infecção além de associar [...] com as manifestações das lesões precursoras até a evolução da neoplasia. Foi possível constatar a forte associação da infecção com a evolução da neoplasia cervical, no entanto, ainda são necessários estudos que elucidem melhor certos aspectos da infecção do vírus HPV que agem sobre o colo do útero para que as ações de prevenção e combate a doença sejam mais eficazes. Abstract in spanish Este artículo se refiere a una revisión de literatura sobre el virus HPV y la neoplasia cervical, con el objetivo de levantar aspectos de la infección del virus que influye en el curso natural del cáncer de cuello del útero tales como: la tipologia del virus, la duración y la persistencia de la infe [...] cción además de asociarlo a las manifestaciones de las lesiones precursoras hasta la evolución de la neoplasia. Ha sido posible constatar la fuerte asosiación de la infección con la evolución de la neoplasia cervical, entretanto, aún son necesarios estudios que eluciden mejor ciertos aspectos de la infección del virus HPV que actúa sobre el cuello del útero para que las acciones de prevención y combate a la enfermedad sean más eficaces. Abstract in english This article refers to a review of literature about the HPV virus and the cervical neoplasia, aiming at raising aspects of the virus infection which influences in the natural development of the uterine cervical cancer such as: the type of virus, the duration and the persistence of the infection and [...] also the association with the manifestations of the preceding lesions up to the evolution of the neoplasia. It was possible to notice the strong association of the infection with the evolution of the cervical neoplasia, however, studies to better elucidate certain aspects of the infection of the HPV virus that acts on the uterine cervix are still necessary so that the actions of prevention and fight against the disease will be more efficient.

Janete Tamani Tomiyoshi, Nakagawa; Janine, Schirmer; Márcia, Barbieri.

2010-04-01

139

Therapeutic comparison of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages I b2-II a cervical cancer  

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Objective: To compare the short-term and long-term therapeutic response of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages I b2-II a cervical cancer. Methods: One hundred and fifty-one patients with stages I b2-II a cervical cancer were treated with preoperative intra-arterial chemotherapy before radical hysterectomy was carried out. Patients in study group (n = 113) received uterine artery chemoembolization (UACE), while patients control group(n = 38) received internal iliac anterior trunk arterial chemotherapy. Radical hysterectomy was carried out in all patients within 2-4 weeks after UACE or chemotherapy. The tumor size was measured before and after the procedure,and the survival rate at 2 and 5 years after treatment was calculated. Results: The mean maximum diameter of the tumors was (4.58 ± 0.37) cm before interventional therapy, and it was (2.11 ± 0.24) cm in two weeks after interventional therapy. The complete response rate of study group and control group was 31.9% and 21.1% respectively. The total effective rate of study group and control group was 94.7% (107/113) and 76.3% (29/38) respectively. The effective rate of study group two weeks after therapy was significantly higher than that of control group. No surgical margin infiltration was observed in both groups. Pathological findings in study group included vascular invasion around surgical margin (n =lar invasion around surgical margin (n = 3), parametrial invasion (n = 5) and pelvic lymph node metastasis (n = 6), while in control group vascular invasion around surgical margin, parametrial invasion and pelvic lymph node metastasis were found in one, two and one cases respectively. The two-year and five-year survival rate in study group were 80.9% (68/84) and 73.4% (47/64) respectively, while the two-year and five-year survival rate in control group were 81.3% (26/32) and 75.0% (18/24) respectively. No significant difference in survival rate existed between two groups. Conclusion: Uterine artery chemoembolization can markedly reduce the volume of cervical cancer,which is very helpful for surgical resection. The therapeutic effectiveness of UACE is superior to internal iliac anterior trunk arterial chemotherapy, therefore, UACE should be regarded as neo-adjuvant intra-arterial chemotherapy of first choice for patients with stages I b2-II a cervical cancer. (authors)

140

EVALUATION OF P16INK4A PROTEIN AS A BIOMARKER FOR CERVICAL INTRAEPITHELIAL NEOPLASIA AND SQUAMOUS CELL CARCINOMA OF THE UTERINE CERVIX  

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Full Text Available The association of human papilloma virus (HPV infection and cervical intraepithelial neoplasia (CIN is well known. Interaction of HPV proteins with cellular regulatory proteins leads to up regulation of p16INK4A. The aim of this study was to evaluate p16INK4A protein as a biomarker for CIN lesions and squamous cell carcinoma on biopsy specimens of patients who underwent biopsy of the uterine cervix due to abnormal cytological finding.The authors analyzed biopsies from 50 patients with CIN and invasive squamous cell carcinoma of the uterine cervix. Expression of p16INK4A in CIN and invasive squamous cell carcinoma was immunohistochemically analyzed by using monoclonal anti-p16INK4A antibody.A total of 50 patients with CIN and invasive squamous cell carcinoma of the uterine cervix (mean age 40.2±11.5 years, range 20-74 years were analyzed. CIN I lesions were found in 27 (54%, CIN II/CIN III lesions in 9 (18%, and invasive squamous cell carcinoma in 14 (28% patients. Differences in the expression of p16INK4A between CIN I, CIN II/CIN III and squamous cell carcinoma were statistically significant (p<0.0001. Expression of p16INK4A showed low sensitivity (7%, specificity (8%, positive predictive value (8%, and negative predictive value (7% for CIN I. Sensitivity, specificity, positive predictive value, and negative predictive value of p16INK4A were 78%, 61%, 30%, and 93% for CIN II/CIN III, and 100%, 75%, 61%, and 100% for squamous cell carcinoma, respectively.Results of this study suggest that p16INK4A protein may be a sensitive biomarker for CIN II/CIN III lesions and invasive squamous cell carcinoma of the uterine cervix.

Biljana ?or?evi?

2011-06-01

141

Análisis de expresión global del cáncer cérvico uterino: rutas metabólicas y genes alterados / Global expression analysis in uterine cervical cancer: Metabolic pathways and altered genes  

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Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish La infección por virus de papiloma de alto riesgo (VPH) es considerada como el factor etiológico más importante del cáncer cérvico uterino (CaCU). Con el fin de determinar el patrón de expresión global e identificar algunos posibles genes marcadores del CaCU, se utilizaron microhileras de DNA que co [...] ntenían 8,000 secuencias que codificaban para transcritos diferentes, para estudiar los perfiles de expresión de cinco líneas celulares derivadas de CaCU, tres muestras tumorales conteniendo VPH 16 y tres muestras normales negativas para la presencia de VPH. Se identificaron los niveles de expresión de genes relacionados con diferentes rutas metabólicas. Se llevó a cabo el análisis de agrupamiento jerárquico y posteriormente se confirmó la sobrexpresión de dos genes mediante RT-PCR. Estos dos genes se encontraron sobrexpresados en biopsias tumorales cervicales. Uno de ellos, el gen de IL6, que ha sido previamente reportado en relación con CaCU, así como el gen de la matriz-metaloproteasa 10 (MMP10) por primera vez relacionado con esta neoplasia. El análisis de agrupamiento jerárquico, además, reveló que las muestras que contienen el mismo tipo viral están asociadas, sugiriendo posibles diferencias en expresión entre tipos virales. Abstract in english High risk human papillomavirus (HPV) infection is considered to be the most important etiological factor of Cervical Uterine Cancer. In order to determine the global expression pattern and to identify possible molecular markers of cervical cancer, cDNA arrays with probe sets complementary to 8,000 h [...] uman genes were used to examine the expression profiles among 5 cell lines derived from human cervical cancer, three HPV16(+) tumor samples and three normal cervical tissues HPV(-). The levels of expression of different cellular processes were identified. Hierarchical clustering was performed and the gene expression using RT-PCR was confirmed. Two genes were found to be consistently overexpressed in invasive cervical cancer biopsies; one of them, IL-6 was previously reported to be overexpressed in cervical cancer and one novel gene, MMP10, previously not known to be related to cervical cancer. Hierarchical clustering of the expression data revealed that samples with common HPV type infection grouped together, maybe this could mean that differences between HPV types could be indirectly determined by expression profiles.

Guelaguetza, Vázquez-Ortíz; Patricia, Piña-Sanchez; Alfredo, Hidalgo; Minerva, Lazos; José, Moreno; Isabel, Alvarado; Fernando, Cruz; Dulce M, Hernández; Carlos, Pérez-Plascencia; Mauricio, Salcedo.

2005-06-01

142

Cervical elongation following sacrospinous hysteropexy: a case series.  

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In recent years, pelvic floor surgeons have increasingly repaired pelvic organ prolapse around an intact uterus. Uterine conservation and hysteropexy have been driven by patient preference, less risk of mesh erosion, shorter operative time, and decreased blood loss and postoperative pain. We present a case series of patients with cervical elongation after vaginal sacrospinous hysteropexy using polypropylene mesh arms, a novel technique developed by the senior author. We defined cervical elongation as greater than or equal to a two-fold increase in cervical length compared with preoperative measurements. Of the 8 patients who underwent this procedure, 5 (62.5 %) had cervical elongation during the first year postoperatively. In the most severe case, the cervix extended to 4 cm beyond the hymenal ring. Most of the patients were mildly symptomatic and chose expectant management. The cases are reviewed in detail. A brief literature review on cervical elongation is presented. PMID:24297063

Hyakutake, Momoe Tina; Cundiff, Geoffrey William; Geoffrion, Roxana

2014-06-01

143

Japanese patterns of care study of postoperative radiotherapy for uterine cervical cancer. The assessment of treatment process of the 1995-2005 surveys  

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The purpose of the study is to evaluate Japanese national practice patterns for patients undergoing postoperative radiotherapy for uterine cervical cancer. The Japan Patterns of Care Study (JPCS) collected the data of patients who were treated postoperative radiation therapy between 1995-1997 (JPCS 95-97), 1999-2001 (JPCS 99-01) and 2003-2005 (JPCS 03-05). Over 80% of patients were treated with external beam RT (ERT). ERT dose ranged from 45 to 50.4 Gy for over 70% of patients. The utilization rates of CT-simulation, multi-leaf collimator and over 10 MV photon energy were increased among three JPCS surveys. Positive lymph nodes, capillary lymphatic space tumor involvement and deep stromal invasion was the main reasons of adaptation of the postoperative radiotherapy. Compared with the previous 2 PCS studies, the patient who received concurrent chemoradiation was increased in JPCS 03-05 (6, 9% to 25%). (author)

144

High-dose-rate interstitial brachytherapy with computed tomography-based treatment planning for patients with locally advanced uterine cervical carcinoma  

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The aims of this study were to carry out a dose volume analysis of high-dose-rate interstitial brachytherapy with computed tomography-based treatment planning and to investigate the treatment outcome of patients with locally advanced bulky and/or irregularly shaped uterine cervical carcinoma. Between July 2003 and December 2007, 15 patients were treated with external beam radiation therapy and high-dose-rate interstitial brachytherapy with or without intracavitary brachytherapy. Seven patients were treated with interstitial brachytherapy alone, and 8 were treated with combined use of intracavitary and interstitial brachytherapy. A comparison of the volume and dose parameters with intracavitary and interstitial brachytherapy in patients who received both treatments showed that the median D90 of the high-risk clinical target volume per fraction was 4.4 Gy with intracavitary brachytherapy and 5.6 Gy with interstitial brachytherapy, and the median V100 was 66% with intracavitary brachytherapy and 85% with interstitial brachytherapy. The median D2cc of the bladder with intracavitary and interstitial brachytherapy per fraction was 5.5 Gy and 4.7 Gy, respectively, and the median D2cc of the rectum with intracavitary and interstitial brachytherapy was 5.9 Gy and 4.1 Gy, respectively. The median follow-up time was 37 months, and the overall and progression-free survival rates for all patients at 3 years were 78% and 51%, respectively. The actuarial 2-year and 3-year locoregionThe actuarial 2-year and 3-year locoregional control rates were 80% and 71%, respectively. Dose distribution was improved with image-based interstitial brachytherapy, and satisfactory local control was achieved for patients with locally advanced uterine cervical carcinoma in which intracavitary brachytherapy may result in a suboptimal dose distribution. (author)

145

Características clínico patológicas del cáncer de cérvix uterino recurrente después de cirugía radical primaria. / Clinical and pathological features of recurrent uterine cervical cancer after primary radical surgery  

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Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Objetivo: Describir las características clínico patológicas del cáncer de cérvix uterino recurrente, sitio y tiempo de recurrencia, y sobrevida después de la recurrencia de acuerdo a las variables de pronóstico en pacientes con cirugía radical primaria. Material y métodos: Estudio descriptivo, obser [...] vacional y retrospectivo, tipo serie de casos, realizado en el Instituto Nacional de Enfermedades Neoplásicas de Lima Perú entre 1990 y 2005. Se incluyeron todas las pacientes con cáncer de cérvix uterino estadios IB1 y IIA a quienes se les realizó cirugía radical primaria y que tuvieron recurrencia. Las curvas de sobrevida fueron construidas con el método de Kaplan-Meier. Resultados: Se realizaron 609 histerectomías radicales tipo III, 53(8,7%) tuvieron recurrencia. La edad promedio al diagnóstico de la recurrencia fue 44,5 años, el tiempo medio desde la cirugía hasta la recurrencia 18,9 meses y el sitio de recurrencia más frecuente fue a distancia (41,5%) seguido por recurrencia central y pélvica. El sitio de recurrencia y los márgenes quirúrgicos tuvieron significancia estadística con respecto al tiempo de recurrencia. La terapia de salvataje más frecuente fue la radioterapia (45%). La sobrevida promedio después de la recurrencia fue 26,9 meses y la tasa de sobrevida a 5 años 9,4%. Conclusiones: El cáncer cervical recurrente es poco frecuente, afecta a mujeres jóvenes y el sitio de recurrencia más frecuente es metástasis a distancia. El tiempo de recurrencia es más corto cuando la recurrencia es central y los márgenes quirúrgicos están afectados. La sobrevida después de la recurrencia en cáncer cervical tratado con cirugía radical es baja. Abstract in english Objective: To describe clinical and pathological features of recurrent uterine cervical cancer, including site and time to recurrence and survival after primary radical surgery. Methods: Descriptive, observational case series study conducted at the Instituto Nacional de Enfermedades Neoplásicas in L [...] ima between 1990 and 2005. Patients with recurrent uterine cervical cancer stages IB1 and IIA who had been treated with primary surgical resection were included. Kaplan-Meir survival curves were constructed. Results: 609 radical hysterectomies type II were performed; 53 (8.7%) had a recurrence. Mean age at diagnosis of recurrence was 44.5 years; mean time from surgery to recurrence was 18.9 months, and the most common site for recurrence was distant recurrence (415%), followed by central recurrence and pelvic recurrence. Site of recurrence and surgical margins had statistical association with time to recurrence. The most frequent salvage therapy was radiotherapy (45%). Mean survival time after recurrence was 26.9 months, and survival rate at 5 years was 9.4%. Conclusions: Recurrent uterine cervical cancer is not frequent, its affects young females causing distant metastasis mainly. Time to recurrence is shorter when recurrence is central and surgical margins are involved. Survival time after recurrence in patients treated surgically is short.

Pedro, Aguilar; Henry, Valdivia.

2012-03-01

146

Dose to the non-involved uterine corpus with MRI guided brachytherapy in locally advanced cervical cancer  

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Background and purpose: This study evaluates the impact of MRI guided adaptive brachytherapy (BT) on uterine corpus dose. Material and methods: 84 patients with median follow-up of 18 months were analysed. MRI based BT was done according to GEC-ESTRO guidelines. Non-involved uterine corpus at the time of BT was contoured and the uterine corpus dose (D90 and D98) was evaluated for (1) standard loading pattern with source loading to the tip of the tandem and (2) optimised dose plan. Tandem lengths and heights of the 85 Gy isodose were recorded. Results: Dose optimisation resulted in a reduction of active tandem length of 0.4 ± 0.4 cm leading to lowering the D90 to the non-involved uterine corpus from 63.8 ± 9.5 Gy to 56.7 ± 7.5 Gy EQD2 (p < 0.0001). Mean active tandem length was 5.0 ± 1.0 cm, and the height of the 85 Gy isodose was 5.7 ± 1.0 cm in optimised plans. Conclusions: MRI guided dose optimisation lowered the dose to the uterine corpus. However, a total EBRT + BT dose larger than 50 Gy was obtained in 99% of patients. Assuming that 45–50 Gy is sufficient to eradicate microscopic disease, the lowering of uterus corpus dose is not expected to induce additional uterine corpus recurrences in the setting of MRI guided adaptive BT. This hypothesis should be tested in a larger number of patients as e.g. the EMBRACE study

147

Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino / Human papillomavirus genotyping of cervical uterine preneoplastic lesions in a high risk area  

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Full Text Available [...] Abstract in english The relationship between human papillomavirus (HPV) and uterine cervical cancer (UCC) is widely known and accepted. Aim: To determine the frequency of genotypes of HPV in cervical preneoplastic lesions in a high risk area of UCC. Material and Methods: Using a combination of PCR and Reverse Line Blot [...] technique, 235 formalin fixed paraffin embedded samples, with diagnosis of low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL) were genotyped. Results: HPV was detected in 61.2% of LSIL and 78.1% of HSIL. The main genotypes found were HPV 16, 18, 31, 45, 56 y 58. HPV 16 was the most common in both LSIL (18.1%) and HSIL (36.9%). HPV 16 or 18 were present in 25.1% and 47.1% of the LSIL and HSIL respectively. In both LSIL and HSIL, the predominant viral genotypes were those types classified as with a high oncogenic risk. Conclusions: HPV genotypes 16, 18, 31, 45, 56 y 58 were the most common in our series. HPV 16 and 18, viral types with high oncogenic risk and included in commercial vaccines, were found in 25.1% and 47.1% of LSIL and HSIL, respectively.

JAIME, LÓPEZ M; CARMEN GLORIA, ILI G; PRISCILLA, BREBI M; PATRICIA, GARCÍA M; ITALO, CAPURRO V; PABLO, GUZMÁN G; EUGENIO, SUÁREZ P; JOSÉ MANUEL, OJEDA F; JUAN CARLOS, ROA S.

1343-13-01

148

Can Uterine Sarcoma Be Found Early?  

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... screening tests for cervical cancer, see our document Cervical Cancer . Last Medical Review: 05/12/2014 Last Revised: 03/18/2015 Back to top » Guide Topics What Is Uterine Sarcoma? Causes, Risk Factors, and Prevention Early Detection, Diagnosis, and Staging Treating Uterine Sarcoma ...

149

Human papilloma virus early proteins E6 (HPV16/18-E6) and the cell cycle marker P16 (INK4a) are useful prognostic markers in uterine cervical carcinomas in Qassim Region--Saudi Arabia.  

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Cervical cancer is a common and an important public health problem for adult women in developing countries. In contrast, cervical cancer incidence is low in Saudi Arabia. High-risk types of human papilloma viruses (HPV16 and HPV18) are the most significant risk factors for cervical cancer. HPV16/18-E6 oncoprotein is associated with HPV etiology, viral persistence and epithelial transformation. Cell cycle protein p16 INK4a (p16) plays an important role in the pathophysiology of cervical carcinomas. The aims of this study were to investigate the expression of HPV16/18-E6 and p16 in uterine cervical carcinomas in Qassim Region--Saudi Arabia, and to relate the results to the established clinicopathological prognostic parameters (age of the patient, educational level, birth control methods, number of pregnancy, smoking status, degree of histological differentiation, clinical stage, and lymph node metastasis) The study included 40 specimens of uterine cervical squamous cell carcinomas diagnosed and confirmed by biopsy. Histopathological classification of cervical tumors cases was performed according to the International Federation of Gynecology and Obstetrics (FIGO). Immunohistochemical analysis for HPV16/18-E6 and p16 were carried out on formalin-fixed paraffin-embedded sections of cervical tissues using avidin-biotin peroxidase method. There was a significant statistical correlation between HPV16/18-E6 expression in cervical carcinoma and nationality, smoking status and size of the tumor. HPV16/18-E6 oncoprotein expression in normal lymphocytes and endothelial cells in the tumor tissues and the adjacent normal cervical tissues suggest the possibility that HPV infection might spread to other organs through blood circulation. P16 expression has been correlated with high grade, stage of cervical SCC and HPV16/18-E6 expression. The current study supports the critical function of p16 and HPV16/18-E6 as specific markers for cervical carcinoma. However the potential for usage of p16 and HPV16/18-E6 as prognostic markers will require detailed follow data for a larger group of patients. PMID:24925218

Omran, O M; AlSheeha, M

2015-01-01

150

Conocimientos sobre prevención del cáncer cérvico-uterino en los adolescentes / Knowledge on the prevention of the cervical-uterine cancer in the adolescents  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish En Cuba, al igual que en el resto de los países occidentales, el cáncer cérvico-uterino se encuentra en segundo lugar de morbilidad oncológica en mujeres de 20 a 30 años; y a ctualmente está considerado como una infección de transmisión sexual. Hay estudios que revelan información deficiente por par [...] te de los adolescentes en cuanto a las infecciones de transmisión sexual y sus consecuencias. Es por ello, que en el período comprendido entre febrero y noviembre de 2009 se realizó una investigación descriptiva con el objetivo de identificar los conocimientos sobre prevención del cáncer cérvico-uterino en los adolescentes de la ESBU Manuel Sanguily, del municipio Matanzas. El universo estuvo integrado por los alumnos de noveno grado, y para la selección de la muestra se utilizó un muestreo probabilístico por conglomerados monoetápico. Se aplicó un cuestionario, cuyos resultados relevantes indicaron que los varones iniciaron sus primeras relaciones sexuales a los 13 años y las hembras a las edades de 13 y 14 años, representado un 57,1 % y 50 %, respectivamente. Solo el 12,7 % de los adolescentes identificó al virus del papiloma humano como factor de riesgo en la génesis del cáncer cérvico-uterino. El bajo nivel de conocimientos para la prevención de este tipo de cáncer predominó en el 92,7 % de la muestra. Se concluye que en el grupo de adolescentes estudiados, lo más frecuente fue el inicio temprano de las relaciones sexuales, tanto para varones como para hembras, aunque estas últimas representaron solo el 10 %. Se identificó desconocimiento sobre el virus del papiloma humano como agente causal de esta morbilidad, y pobre conocimiento sobre cómo prevenirlo. Abstract in english In Cuba, as in the rest of the Western countries, the cervical-uterine cancer is in the second place of oncologic morbidity in 20-to-30 years-old women; currently it is considered a sexually transmitted infection. There are some studies revealing deficient information on the part of the teenagers as [...] for the sexually transmitted diseases and theirs consequences. That is why, in the period from February to November 2009 we carried out a descriptive investigation with the objective of identifying the knowledge on the prevention of the cervical-uterine cancer the students of the Secondary School Manuel Sanguily, Municipality of Matanzas, have. The universe was formed by the nine grade students, and to select the sample we used a probabilistic sampling by mono-stage conglomerates. A questionnaire was applied and the results indicated that the males began their first sexual relationships to the 13 years and the females to the ages of 13 and 14 years, representing 57,1 % and 50 %, respectively. Only 12,7 % of the teenagers identified the human papilloma virus as a risk factor in the genesis of the cervical-uterine cancer. The low level of knowledge for the prevention of this kind of cancer prevailed in 92,7 % of the sample. We concluded that in the group of teenagers we studied, the most frequent fact was that they began early having sexual relationships, both boys and girls, although the last ones represented only 10 %. We identified ignorance on the human papilloma virus and poor knowledge about how to prevent it as the casual agent of this morbidity.

Regla Mercedes, García Rosique; Adelaida, Torres Triana; Marlén, Rendón Quintero.

2011-04-01

151

Adenocarcinoma involving the uterine cervix: magnetic resonance imaging findings in tumours of endometrial, compared with cervical, origin  

International Nuclear Information System (INIS)

To determine the distinctive magnetic resonance imaging (MRI) features of cervical and endometrial adenocarcinoma that present clinically as cervical mass. From 1999 to 2002, 56 patients with adenocarcinoma on the initial biopsy of a cervical mass underwent MRI at our institution. Of these, 42 had a visible mass on MRI. Pathology review of all available tissue was the reference standard. A site of origin was determined by the pathologist in 38 of the 42 patients, and these were the cases evaluated; of these patients, 32 cases had adenocarcinoma and 6 had adenosquamous cancers. Findings were significantly more prevalent in patients with adenocarcinomas of endometrial, compared with cervical, origin for endometrial thickening (11 [73%] and 3 [13%], respectively; P = 0.0003), endometrial mass (11 [73%] and 1 [4%], respectively; P < 0.0001), endometrial cavity expansion by a mass (9 [60%] and 2 [9%], respectively; P = 0.001), and invasion of myometrium from endometrium (9 [60%] and 0, respectively; P < 0.0001). Adenocarcinomas of the endometrium that involve the cervix have MRI features that help distinguish them from primary adenocarcinomas of the cervix. (author)

152

La promoción de salud dirigida a reducir los factores de riesgo de cáncer cérvico uterino / Health promotion aimed to reducing uterine cervical cancer risk factors  

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Full Text Available La primera Conferencia Internacional sobre la Promoción de la Salud celebrada en Ottawa, el 21 de noviembre de 1986, definió la promoción de la salud como “el proceso de permitir a la gente aumentar su control sobre su salud y por lo tanto mejorarla”. Se reconoce claramente que la promoción de la sa [...] lud va más allá de los estilos de vida, en la cual la educación para la salud constituye, junto a la comunicación y a la participación social, herramientas necesarias para su instrumentación en el primer nivel de atención. En la práctica cotidiana se desconoce de forma reiterada el valor que tiene el reconocimiento adecuado de las dimensiones de la promoción de salud, desde una perspectiva holística, dirigidas a reducir los factores de riesgo de cáncer cérvico uterino. El propósito del estudio fue realizar una contribución teórica a la promoción de salud para contribuir al fortalecimiento del Programa Nacional de Diagnóstico Precoz del Cáncer Cérvico Uterino. Al considerar el valor de esta disciplina desde sus dimensiones, el profesional de la salud dispone de una base teórica que guíe las acciones dirigidas a la reducción de factores de riesgos de este tipo de cáncer en la población femenina. Abstract in english The first International Conference on Health Promotion celebrated in Ottawa on November 21st, 1986, defined health promotion as “the process allowing people to increase the control on their health and therefore to improve it”. It is clearly understood that health promotion goes beyond life styles, a [...] nd also includes education for health, communication and social participation, necessary tools for its instrumentation in the first health care level. In every day practice it is continually not recognized the value of the adequate acknowledgement of health promotion dimensions, from a holistic perspective, aimed to reducing the uterine cervical cancer risk factors. The purpose of the research was theoretically contributing to the strengthening of the National Program of Uterine Cervical Cancer Precocious Diagnosis. When considering the value of this discipline in all its dimensions, the health care professional has a theoretical base to guide the actions aimed to reducing the risk factors of this kind of cancer among the female population.

Misleny, Martínez Pérez; Juan Carlos, de la Concepción Cárdenas; Ariel, Pérez González.

2014-06-01

153

Studies on serum protein fractions of patients with uterine cervical cancer undergoing radiotherapy. Relationship between changes in serum protein fractions and prognosis  

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The purpose of this study was to evaluate the correlation between changes in serum protein fractions and patient prognosis. The subjects were 84 patients with uterine cervical cancer treated with combined external pelvic irradiation and intracavitary irradiation using a remote afterloading system (RALS). Twenty one normal women served as controls. Serum levels of 23 protein components were determined before and after radiotherapy. All patients were followed up for 4 to 8 years after radiotherapy. Pretreatment serum levels of prealbumin (Prealb), ?2HS glycoprotein (?2HS), ?2-plasmin inhibitor (?2PI), transferrin (Tf), plasminogen (Pmg), albumin (Alb), IgM, and hemopexin (Hx) were significantly lower in the group of cervical cancer patients than the control group; and serum levels of ?1-antichymotrypsin (?1X), haptoglobin (Hp), C9, fibrinogen (Fib), ceruloplasmin (Cp), ?1-acid glycoprotein (?1AG), ?1-antitrypsin (?1AT), and C4 were elevated. At the completion of radiotherapy, HP, C4, and Fib levels were significantly lower than those before radiotherapy; Prealb, ?2HS, and ?2PI were elevated. In patients who survived 4 years and 8 years, pretreatment levels of Cp, ?1AG, Hp, and C9 were significantly reduced and Tf was elevated, as compared with those who died within 4 years. In those who survived more than 4 years, pourvived more than 4 years, posttreatment levels of ?1AT, Hp, ?1X, Cp, and C9 were significantly reduced, although the serum level of C4 was elevated. Survival positively correlated with pretreatment levels of Tf, Pmg, and ?1AT, but negatively correlated with AT III, Cp, C1Inh, IgA, ?1AG, and C9. For posttreatment levels, it positively correlated with Pmg, C4, Prealb, Alb, ?2M, and Hp, but negatively correlated with Tf, ?2PI, AT III, ?1AT, C1Inh, C9, and IgA. (N.K.)

154

Prediction of lymph node status in uterine cervical cancer with 18FDG-PET/CT-value of primary tumor uptake  

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Purpose. To evaluate the value of 18F-fluoro-2-deoxyglucose (F.D.G.) PET-CT and maximal standardized uptake value (SUVmax) of the primary tumor for lymph node staging in cervical cancer. Materials and methods. This retrospective study involved a series of 18 consecutive patients who had benefited from PET-CT and MRI at initial staging for a stage IB or higher cervical carcinoma. The SUVmax of each primary tumor was measured retrospectively. All patients had been previously treated by radio chemotherapy. Lymph node status was obtained in 12 of 18 cases. Results. The sensitivity and specificity for determining lymph node status was 80 and 86%, respectively, for PET-CT, and 80 and 71% for MRI. In 16.6% of cases, PET-CT revealed unknown sus-diaphragmatic lesions. SUVmax of the primary tumor was significantly higher in the N+ than in the N- group (15.6 ±1.6 vs 8.5±3.9, p max of a primary cervical cancer seems to be a good predictor of lymph node status. This could lead to an intensification of treatment for patients whose SUVmax is higher than 10.8. A prospective study would allow to assess a potential benefit of treatment intensification for patients with SUVmax higher than 10.8. (authors)

155

A case report of anal cancer preceded by perianal Paget's disease after irradiation for uterine cervical cancer and review of perianal Paget's disease in Japan  

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The patient was a 59-year-old woman. Total hysterectomy and irradiation were performed for uterine cervical cancer 25 year previously. Paget's cells resembling signet ring cells were found in the epidermis, and anal cancer was present adjacent to them. The histological diagnosis of the anal cancer was mainly well differentiated adenocarcinoma, but mucinous carcinoma was present containing signet ring cells at sites contiguous with the anal glands, and lymphatic permeation was noted in the dermis. The cancer and the Paget's cells were both positive for PAS and alcian blue staining and were negative for PB/KOH/PAS staining. Furthermore, such findings as atypia of the glandular ducts and endoarteritis were detected in the underlying mucosa. Therefore, it was considered that this patient had anal cancer derived from the anal glands, that the Paget's cells were due to the intraepidermal extension of signet ring cells, and that the cancer may have been related to her previous irradiation. Reports of cancer of the rectum and anus complicated by Paget's lesion in Japan were reviewed and studied with regard to the histogenesis. It was concluded that peri-anal Paget's lesion had a close relationship with anal cancer derived from the anal glands. (author)

156

Cerebral metastasis of cervical uterine cancer: report of three cases Metástases cerebrais de câncer de colo de útero: relato de três casos  

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Full Text Available Cervical uterine cancer (CUC spreads locally (pelvis and paraortic lymphnodes or distantly (lungs, liver and bones. Metastasis to central nervous system (CNS are rare. There are about 80 cases reported in the literature. Outcome is poor and survival varies from 3 to 6 months. Three cases of CNS metastasis from CUC are reported, one infratentorial and two supratentorials in location. In one patient, the initial manifestation was due to the cerebral lesion, a feature reported for the first time. All cases were treated by surgery, radiotherapy and/or chemotherapy. Clinical findings and treatment options of these rare lesions are reviewed.Tumores do cólo uterino se disseminam por contigüidade ou via hematogênica (pulmão, fígado e ossos. Metástases para sistema nervoso central são incomuns. Apenas cerca de 80 casos são citados na literatura. Manifestações clínicas são devidas à hipertensão intracraniana e a déficits focais. A sobrevida varia de 3 a 6 meses. Três casos são relatados sendo um infratentorial e dois supratentoriais. No primeiro, o diagnóstico da metástase antecedeu o da lesão uterina. No segundo, houve 5 anos sem recidiva após a cirurgia, fato este inédito. O tratamento foi cirurgia, radioterapia e/ou quimioterapia. A discussão enfatiza manejo multidisciplinar destas raras lesões.

Joacir Graciolli Cordeiro

2006-06-01

157

Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy; Aberracoes cromossomicas instaveis em linfocitos de pacientes com cancer de colo de utero  

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Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of {sup 69} Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

Magnata, Simey de Souza Leao Pereira

2002-09-01

158

Phase II study of radiation therapy combined with weekly nedaplatin in locally advanced uterine cervical carcinoma. KGROG0501. Initial 15 cases  

International Nuclear Information System (INIS)

Locally advanced uterine cervical carcinoma (LAUCC) treated with chemoradiotherapy is considered to be the standard treatment. However, no evidence of its efficacy and safety has been obtained from the Japanese. Furthermore, the total dose of Japanese radiation therapy protocol is lesser than that of United States of America (USA) which indicated that chemoradiotherapy for LAUCC is better than radiation therapy alone by phase III clinical trials. Thus, the current phase II study was designed. The current criteria are as follows. squamous cell carcinoma or adenocarcinom, Ib, IIa, IIb with bulky tumor (diameter: 40> mm) or pelvic lymph node swelling (diameter: >10 mm), IIIa, IIIb and IVa with no para-aortic lymph node swelling (diameter: >10 mm). Age: 20-75 years. PS: 0-2. Radiation therapy is a combination of external beam radiation therapy (total dose: 50-52 Gy with central shielding after 30-32 Gy) with high-dose rate intracavitary irradiation (24-30 Gy/4-6 fractions to point A). Chemotherapy is weekly nedaplatin infused by intravenous (30 mg/m2/week, total 150 mg/m2/5 weeks). The current report was about the preliminary results of initial 15 cases of this phase II study. (author)

159

Tendência da mortalidade por câncer do útero no Município de São Paulo entre 1980 e 1999 Mortality trends from uterine cervical cancer in the city of São Paulo from 1980 to 1999  

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Full Text Available O câncer do colo do útero apresenta grande incidência em algumas cidades brasileiras e considerável mortalidade em países em desenvolvimento, não obstante a disponibilidade já antiga de teste de rastreamento. O presente estudo visou avaliar a tendência da mortalidade por câncer de colo do útero, de corpo do útero e por câncer do útero não especificado, no Município de São Paulo, entre 1980 e 1999, por meio do exame das taxas brutas, idade-específica e ajustadas por idade. Os resultados mostraram discreta redução da mortalidade por câncer do colo do útero, queda da mortalidade por câncer de útero não especificado e aumento da mortalidade por câncer do corpo do útero. Conclui-se que a queda da mortalidade por câncer do útero não especificado sinaliza uma melhora na precisão do diagnóstico clínico e na qualidade do preenchimento do atestado de óbito, e indica aumento de cobertura do teste de Papanicolaou.Uterine cervical cancer shows a higher incidence in some Brazilian cities. It is a common cause of death in women from developing countries, despite the longstanding availability of an effective screening test, the Pap smear. This study aimed to evaluate the temporal trends of crude, age-adjusted, and age-specific mortality rates from cervical cancer, endometrial cancer, and cancer of the uterus not otherwise specified (NOS in the city of São Paulo from 1980 to 1999. Results showed a slight reduction in cervical cancer rates, a decrease in NOS uterine cancer rates, and an increase in endometrial cancer mortality rates. The fall in mortality from NOS uterine cancer indicates an improvement in diagnostic accuracy and quality of information on death certificates and may point to an increase in coverage of cervical cancer screening using the Pap smear.

Luiz Augusto Marcondes Fonseca

2004-02-01

160

Results of radiotherapy for stage III uterine cervical carcinomas and preliminary study of combined radiotherapy and transarterial infusion chemotherapy  

International Nuclear Information System (INIS)

This is a retrospective analysis of 55 patients with stage III carcinoma of the uterine cervix treated with radiation from November 1984 through December 1991. Eleven of the patients were treated with radiation and transarterial infusion chemotherapy (TAI), using cis-platinum and pepleomycin. The 3- and 5-year cumulative survival rates for all patients were 61% and 58%, respectively, and the 3-year cumulative survival rate for the group with combined radiation and TAI was 47%. According to initial failure site, the locoregional recurrence rate was 36.8%, and that for para-aortic lymph node metastasis and distant metastasis was 31.6%. The failure pattern was similar between the irradiation only group and the group with combined radiation and TAI. The incidence of intestinal complications of grades 1 and 2 was 20%. Irradiation combined with TAI did not increase the incidence of complications. (author)

161

Invasive cervical carcinoma: methods of investigation, diagnostic strategy; Carcinomes invasifs du col uterin: methodes d`exploration strategie diagnostique  

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The authors review various techniques, including endo-sonography, computed tomography, magnetic resonance imaging and lymphography for the pre therapeutic evaluation of cancer of the uterine cervix, as well as for post therapeutic follow up. The pre-therapeutic examination should evaluate size of the primary tumor and tumor extension to vagina, parametria, bladder, rectum and pelvic sidewall. Pelvic lymph nodes evaluation is assessed by CT, MRI or lymphography. In stage IB, IIA and proximal IIB carcinoma, most patients will be operated and will have an intraoperative lymph node exploration and thus a surgical and clinico-pathological staging will be performed. In this case, clinical staging is often accurate. For larger tumors, radiological exploration will be more thorough for an optimal determination of the tumoral stage. (authors). 72 refs.

Ternier, F.; Rosello, R.; Stefano-Louineau, D. Di.; Le Brigand, B.; Mouillac, G.; Resbeut, M. [Institut Paoli-Calmettes, 13 - Marseille (France); Kind, M. [Fondation Bergonie, 33 - Bordeaux (France)

1997-09-01

162

Is the adaptive tomography of cervical carcinomas necessary?; La tomotherapie adaptative des carcinomes du col uterin est-elle necessaire?  

Energy Technology Data Exchange (ETDEWEB)

The authors report the study of the macroscopic tumour volume (GTV, gross tumour volume) and its possible repercussion on organs at risk during a tomo-therapy with an additional concomitant centro-pelvic irradiation. Ten women with non-operable cervical carcinomas have been treated by tomo-therapy and chemotherapy. A high-energy conical tomography has been performed before each session. Data obtained from these tomographies have been used in the adaptive therapy module of a tomo-therapy planimetry software. It appears that there is no evidence of significant variations of doses at the level of organs at risk with the use of such software. Short communication

Le Tinier, F.; Nickers, P.; Reynaert, N.; Castelain, B.; Lacornerie, T.; Attar, M.; Lartigau, E. [Centre Oscar-Lambret, 59 - Lille (France)

2010-10-15

163

Multi-institutional study of radiation therapy for isolated para-aortic lymph node recurrence in uterine cervical carcinoma: 84 subjects of a population of more than 5,000  

International Nuclear Information System (INIS)

Purpose: Most patients who had any recurrent sites of cancer have been considered to be in their last stage of life. However, recent advances of clinical research reveal some patients achieve long-term survival even in recurrence. Furthermore, for patients who had only one recurrent region, radiation therapy could play an important role. As for uterine cervical carcinoma, the most common recurrent site other than the pelvis is the para-aortic lymph nodes. Thus we conducted the current study. Patients and Methods: Between 1994 and 2003, more than 5,000 uterine cervical carcinoma patients were treated with curative intended treatments at 13 Japanese hospitals. Of these patients, 84 developed para-aortic lymph node recurrence as the only site of initial tumor progression. These patients were treated with external beam radiation therapy. Radiation therapy protocol was as follows: 1.7-2.0 Gy per fraction, 5 fractions per week, and the mean total dose was 50.8 Gy (25-60 Gy). Results: Three- and 5-year overall survival rates of all patients were 49.5% and 31.3%, respectively. Stratified by symptom sign, 3-year overall survival rate of symptom positive was 27.6% and those of the negative was 56.1% (p = 0.018). Three-year overall survival rates of the total dose ?51 Gy and that of ?50 Gy were 58.0% and 42.8%, respectively (p = 0.07). As for morbidity, no patients received Grade 3 or greater late toxicity. Conclusions: The current study suggested that radiation therapy for suggested that radiation therapy for isolated para-aortic lymph node recurrence in uterine cervical carcinoma could have a significant impact on survival

164

Critérios de positividade para cervicografia digital: melhorando a sensibilidade do diagnóstico do câncer cervical Digital cervicography criteria: improving sensitivity in uterine cervical cancer diagnosis  

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Full Text Available O objetivo deste trabalho foi validar critérios de positividade para cervicografia digital. Estudo realizado com 300 mulheres submetidas a protocolo clínico composto por exame citológico, uma avaliação por meio de cervicografia digital sem ampliação de imagem (Avaliação 1, e outra avaliação também usando cervicografia digital mas com ampliação adicional de imagem e os critérios de positividade propostos neste estudo (Avaliação 2. A idade média das mulheres foi de 27,6 anos. Os critérios de positividade para cervicografia digital foram identificados em 111 casos (100% dos testes positivos para lesões precursoras do câncer do colo uterino e em 8 casos (2,6% considerados falso-positivos. As avaliações 1 e 2 classificaram os exames como positivos (163; 54,3% e suspeitos (146; 48,6%, respectivamente. Os resultados revelam que a cervicografia digital foi mais sensível (99,1% e a citologia mais específica (100%. O desempenho alcançado pela cervicografia digital, quando aplicado os critérios de positividade, alcançou sensibilidade 4,5 vezes superior ao desempenho da citologia oncológica, além do baixo custo, sugerindo ser uma técnica factível.This study aimed to validate the scoring criteria for digital cervicography. The study enrolled 300 women submitted to a clinical protocol using cytological examination alone, digital cervicography without image magnification (Evaluation 1, and digital cervicography plus additional image magnification and considering the positive criteria (Evaluation 2. Women's mean age was 27.6 years. Positive criteria for digital cervicography were identified in 111 positive cases with pre-cancerous cervical lesions (100% and in 8 cases classified as false positives (2.6%. Evaluations 1 and 2 classified the tests as positive (163; 54.3% and suspected (146; 48.6%, respectively. According to the findings, digital cervicography was more sensitive (99.1% and cytology more specific (100%. Digital cervicography sensitivity increased by 4.5 times when the positive criteria were applied as compared to cytology alone, besides involving low cost, thus suggesting that it is a viable technique.

Eugênio Santana Franco

2008-11-01

165

Critérios de positividade para cervicografia digital: melhorando a sensibilidade do diagnóstico do câncer cervical / Digital cervicography criteria: improving sensitivity in uterine cervical cancer diagnosis  

Scientific Electronic Library Online (English)

Full Text Available O objetivo deste trabalho foi validar critérios de positividade para cervicografia digital. Estudo realizado com 300 mulheres submetidas a protocolo clínico composto por exame citológico, uma avaliação por meio de cervicografia digital sem ampliação de imagem (Avaliação 1), e outra avaliação também [...] usando cervicografia digital mas com ampliação adicional de imagem e os critérios de positividade propostos neste estudo (Avaliação 2). A idade média das mulheres foi de 27,6 anos. Os critérios de positividade para cervicografia digital foram identificados em 111 casos (100%) dos testes positivos para lesões precursoras do câncer do colo uterino e em 8 casos (2,6%) considerados falso-positivos. As avaliações 1 e 2 classificaram os exames como positivos (163; 54,3%) e suspeitos (146; 48,6%), respectivamente. Os resultados revelam que a cervicografia digital foi mais sensível (99,1%) e a citologia mais específica (100%). O desempenho alcançado pela cervicografia digital, quando aplicado os critérios de positividade, alcançou sensibilidade 4,5 vezes superior ao desempenho da citologia oncológica, além do baixo custo, sugerindo ser uma técnica factível. Abstract in english This study aimed to validate the scoring criteria for digital cervicography. The study enrolled 300 women submitted to a clinical protocol using cytological examination alone, digital cervicography without image magnification (Evaluation 1), and digital cervicography plus additional image magnificat [...] ion and considering the positive criteria (Evaluation 2). Women's mean age was 27.6 years. Positive criteria for digital cervicography were identified in 111 positive cases with pre-cancerous cervical lesions (100%) and in 8 cases classified as false positives (2.6%). Evaluations 1 and 2 classified the tests as positive (163; 54.3%) and suspected (146; 48.6%), respectively. According to the findings, digital cervicography was more sensitive (99.1%) and cytology more specific (100%). Digital cervicography sensitivity increased by 4.5 times when the positive criteria were applied as compared to cytology alone, besides involving low cost, thus suggesting that it is a viable technique.

Eugênio Santana, Franco; Silvia Bomfim, Hyppólito; Rosana Gomes de Freitas Menezes, Franco; Mônica Oliveira Batista, Oriá; Paulo César de, Almeida; Lorita Marlena Freitag, Pagliuca; Nelson Fernando Pacheco da, Rocha.

2653-26-01

166

Ganglio centinela para estadios tempranos en cáncer de cuello uterino / Sentinel lymph node detection in early uterine cervical cancer  

Scientific Electronic Library Online (English)

Full Text Available Objetivo: Determinar la factibilidad y seguridad del ganglio centinela (GC) con el uso combinado del mapeo linfático con Tc 99 y la inyección de colorante azul (patent blue) en pacientes con cáncer de cérvix temprano sometidas a histerectomía radical con linfadenectomía pélvica bilateral. Diseño: Es [...] tudio prospectivo. Institución: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú. Participantes: Pacientes con cáncer temprano de cuello uterino. Intervenciones: Entre diciembre de 2003 y diciembre de 2006, 66 pacientes con cáncer temprano de cuello estadios IA2 (n=2), IB1 (n=63) y IIA (n=1) fueron sometidas a detección del ganglio linfático centinela con linfoscintigrafía el día previo a la operación y mapeo linfático intraoperatorio con colorante azul y sonda detectora de radiación gama. El tratamiento quirúrgico se completó con la realización de la histerectomía radical y linfadenectomía pélvica bilateral, por laparotomía. Principales medidas de resultados: Detección de ganglios centinelas. Resultados: En las 66 pacientes estudiadas se detectó 136 ganglios centinelas, con un promedio de 2,06 por paciente. Se utilizó el método combinado (Tc 99 y patent blue). La localización más frecuente fue la región obturatriz con un 69,9% (n=95). Se halló metástasis en los ganglios pélvicos en 11 pacientes, que fueron correctamente localizadas en el ganglio centinela con una sensibilidad de 100%. Cuando el ganglio centinela fue negativo, no se encontró metástasis en los ganglios no centinela (VPN 100%). Conclusiones: La identificación del ganglio centinela con tecnecio-99 combinado con la inyección de colorante azul es factible y mostró un valor predictivo negativo de 100%. Abstract in english Objective: To determine sentinel node (SN) detection feasibility and safety by using lymphatic mapping with 99m Tc Dextrán and injection of blue dye (patent blue) in patients with early cervical cancer undergoing radical hysterectomy with bilateral pelvic lymphadenectomy. Design: Prospective study. [...] Setting: Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru. Participants: Patients with early cervical cancer. Interventions: Between December 2003 and December 2006, 66 patients with early cervical cancer stages IA2 (n = 2), IB1 (n = 63) and IIA (n = 1) underwent sentinel lymph node detection with lymphoscintigraphy the day before operation and intraoperative lymphatic mapping with blue dye and gamma radiation detection probe. Surgical treatment was completed with radical hysterectomy and bilateral pelvic lymphadenectomy by laparotomy. Main outcome measures: Sentinel node detection. Results: One hundred and thirty-six sentinel nodes were detected in all 66 patients, average 2.06 per patient, by using the combined method 99m Tc dextrán and patent blue. Most common location was the obturator region in 69.9% of cases (n = 95). Pelvic lymph node metastases were found by the sentinel node in 11 patients (sensitivity of 100%). In negative sentinel node cases (55 patients) no metastases were encountered (negative predictive value, NPV = 100%). Conclusions: Sentinel node identification using 99m technetium Dextrán and blue dye injection is feasible and had a negative predictive value of 100%.

Henry, Valdivia; Rossana, Morales; Luis, Taxa; Manuel, Álvarez; Carlos, Santos; Albert, Zevallos; Carlos, Velarde; Marco, Sánchez; Aldo, López; Absalón, Montoya.

167

Comparison of tumor regression rate of uterine cervical squamous cell carcinoma during external beam and intracavitary radiotherapy  

International Nuclear Information System (INIS)

We compared the radioresponse of cervical carcinoma that was closely related to local disease control by the tumor regression rate (RR) during intracavitary radiotherapy (ICRT) and external beam radiotherapy (EBRT) on the presumption that ICRT has a stronger treatment impact than EBRT because of its specific dose distribution. A total of 37 patients were treated by EBRT at 45.0 Gy over 5 weeks, followed by high-dose-rate ICRT at 6.0 Gy per weekly insertion at point A three to five times and by boost EBRT. RR was defined as the slope (day-1) of the tumor-volume shrinkage curve fit to an exponential regression equation. Assuming that the tumors were ellipsoid, the tumor volume was estimated using magnetic resonance (MR) images obtained before treatment, after 45.0 Gy of EBRT, and after the third ICRT insertion. RRs were compared based on the radiotherapy method. RR ranged between -0.008 to 0.093 day-1 (median 0.021 day-1) during EBRT and -0.001 to 0.097 day-1 (median 0.018 day-1) during ICRT, showing no significant difference or correlation between treatments. Contrary to expectations, RR did not directly relate to the impact of physical treatment. RR could be related to biological factors, such as the amount of tumor clearance and changes in tumor consistency during treatment. (author)

168

Lymphedema After Surgery in Patients With Endometrial Cancer, Cervical Cancer, or Vulvar Cancer  

Science.gov (United States)

Lymphedema; Stage IA Cervical Cancer; Stage IA Uterine Corpus Cancer; Stage IA Vulvar Cancer; Stage IB Cervical Cancer; Stage IB Uterine Corpus Cancer; Stage IB Vulvar Cancer; Stage II Uterine Corpus Cancer; Stage II Vulvar Cancer; Stage IIA Cervical Cancer; Stage IIIA Vulvar Cancer; Stage IIIB Vulvar Cancer; Stage IIIC Vulvar Cancer; Stage IVB Vulvar Cancer

2014-12-23

169

Uterine peaking – sonographic sign of vesico-uterine adhesion  

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Full Text Available Objective: In this paper we present our observation of a specific sign on transvaginal ultrasound that may help basic minimal invasive surgeons diagnose vesico-uterine adhesions preoperatively. Methods: The ultrasound images of the latest eleven patients who were preoperatively diagnosed with vesico-uterine adhesions using transvaginal ultrasound were compared with their intraoperative findings. Results: Ultrasonography showed a spectrum of changes from obliterated anterior cul-de-sac to dense fibrosis between the lower uterine segment and cervix with the bladder. Horn- or beak-shaped streaks of tissue with the same density of uterine myometrium is a sign of fundal attachment of vesico-uterine adhesions or of complete anterior cul-de-sac obliteration with adhesions going between the uterus and the anterior abdominal wall. Fine papillary peaking is seen in cases of dense lower uterine segment and cervical fibrosis without fundal involvement. These signs combined with limited mobility of the cervix and bladder base correlated with the presence of dense vesico-uterine adhesions. Conclusion: The described sonographic signs, two static and the other dynamic, may help basic minimal invasive gynecological surgeons who do not have advanced laparoscopic skills and do not feel comfortable dealing with an obliterated anterior cul-de-sac or dense vesico-uterine space fibrosis predict the presence of dense vesico-uterine adhesions allowing them to choose another route that they may be more comfortable with such as vaginal or abdominal hysterectomy or request assistance from a more experienced colleague.

Heaton, Richard L.

2011-01-01

170

Optimum radiotherapy schedule for uterine cervical cancer based-on the detailed information of dose fractionation and radiotherapy technique  

International Nuclear Information System (INIS)

The best dose-fractionation regimen of the definitive radiotherapy for cervix cancer remains to be clearly determined. It seems to be partially attributed to the complexity of the affecting factors and the lack of detailed information on external and intra-cavitary fractionation. To find optimal practice guidelines, our experiences of the combination of external beam radiotherapy (EBRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT) were reviewed with detailed information of the various treatment parameters obtained from a large cohort of women treated homogeneously at a single institute. The subjects were 743 cervical cancer patients (Stage IB 198, IIA 77, IIB 364, IIIA 7, IIIB 89 and IVA 8) treated by radiotherapy alone, between 1990 and 1996. A total external beam radiotherapy (EBRT) dose of 23.4 ? 59.4 Gy (Median 45.0) was delivered to the whole pelvis. High-dose-rate intracavitary brachytherapy (HDR-ICBT) was also performed using various fractionation schemes. A Midline block (MLB) was initiated after the delivery of 14.4? 43.2 Gy (Median 36.0) of EBRT in 495 patients, while in the other 248 patients EBRT could not be used due to slow tumor regression or the huge initial bulk of tumor. The point A, actual bladder and rectal doses were individually assessed in all patients. The biologically effective dose (BED) to the tumor (? / ? = 10) and late-responding tissues (? /? = 3) for both EBRT and HDR-ICBT were calculated. The total BED values to poilated. The total BED values to point A, the actual bladder and rectal reference points were the summation of the EBRT and HDR-ICBT. In addition to all the details on dose-fractionation, the other factors (i.e. the overall treatment time, physicians preference) that can affect the schedule of the definitive radiotherapy were also thoroughly analyzed. The association between MD-BED Gy3 and the risk of complication was assessed using serial multiple logistic regressions models. The associations between R-BED Gy3 and rectal complications and between V-BED Gy3 and bladder complications were assessed using multiple logistic regression models after adjustment for age, stage, tumor size and treatment duration. Serial Coxs proportional hazard regression models were used to estimate the relative risks of recurrence due to MD-BED Gy10 and the treatment duration. The overall complication rate for RTOG Grades 1 ? 4 toxicities was 33.1%. The 5-year actuarial pelvic control rate for all 743 patients was 83%. The midline cumulative BED dose, which is the sum of external midline BED and HDR-ICBT point A BED, ranged from 62.0 to 121.9 Gy10 (median 93.0) for tumors and from 93.6 to 187.3 Gy3 (median 137.6) for late responding tissues. The median cumulative values of actual rectal (R-BED Gy3) and bladder point BED (V-BED Gy3) were 118.7 Gy3 (range 48.8 ? 265.2) and 126.1 Gy3 (range: 54.9? 267.5), respectively. MD-BED Gy3 showed a good correlation with rectal (? =0.003), but not with bladder complications (? = 0.095), R-BED Gy3 had a very strong association (? = 3, B-BED Gy3 also showed significance in the prediction of bladder complications in a trend test (? = 0.0298). No statistically significant dose-response relationship for pelvic control was observed. The Sandwich and Continuous techniques, which differ according to when the ICR was inserted during the EBRT and due to the physicians preference, showed no differences in the local control and complication rates; there were also no differences in the 3 vs. 5 Gy fraction size of HDR-ICBT. The main reasons optimal dose-fractionation guidelines are not easily established is due to the absence of a dose-response relationship for tumor control as a result of the high-dose gradient of HDR-ICBT, individual differences in tumor responses to radiation therapy and the complexity of affecting factors. Therefore, in our opinion, there is a necessity for individualized tailored therapy, along with general guidelines, in the definitive radiation treatment for cervix cancer. This study also demonstrated the strong predictive valu

171

Optimum radiotherapy schedule for uterine cervical cancer based-on the detailed information of dose fractionation and radiotherapy technique  

Energy Technology Data Exchange (ETDEWEB)

The best dose-fractionation regimen of the definitive radiotherapy for cervix cancer remains to be clearly determined. It seems to be partially attributed to the complexity of the affecting factors and the lack of detailed information on external and intra-cavitary fractionation. To find optimal practice guidelines, our experiences of the combination of external beam radiotherapy (EBRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT) were reviewed with detailed information of the various treatment parameters obtained from a large cohort of women treated homogeneously at a single institute. The subjects were 743 cervical cancer patients (Stage IB 198, IIA 77, IIB 364, IIIA 7, IIIB 89 and IVA 8) treated by radiotherapy alone, between 1990 and 1996. A total external beam radiotherapy (EBRT) dose of 23.4 {approx} 59.4 Gy (Median 45.0) was delivered to the whole pelvis. High-dose-rate intracavitary brachytherapy (HDR-ICBT) was also performed using various fractionation schemes. A Midline block (MLB) was initiated after the delivery of 14.4{approx} 43.2 Gy (Median 36.0) of EBRT in 495 patients, while in the other 248 patients EBRT could not be used due to slow tumor regression or the huge initial bulk of tumor. The point A, actual bladder and rectal doses were individually assessed in all patients. The biologically effective dose (BED) to the tumor ({alpha} / {beta} = 10) and late-responding tissues ({alpha} /{beta} = 3) for both EBRT and HDR-ICBT were calculated. The total BED values to point A, the actual bladder and rectal reference points were the summation of the EBRT and HDR-ICBT. In addition to all the details on dose-fractionation, the other factors (i.e. the overall treatment time, physicians preference) that can affect the schedule of the definitive radiotherapy were also thoroughly analyzed. The association between MD-BED Gy{sub 3} and the risk of complication was assessed using serial multiple logistic regressions models. The associations between R-BED Gy{sub 3} and rectal complications and between V-BED Gy{sub 3} and bladder complications were assessed using multiple logistic regression models after adjustment for age, stage, tumor size and treatment duration. Serial Coxs proportional hazard regression models were used to estimate the relative risks of recurrence due to MD-BED Gy{sub 10} and the treatment duration. The overall complication rate for RTOG Grades 1 {approx} 4 toxicities was 33.1%. The 5-year actuarial pelvic control rate for all 743 patients was 83%. The midline cumulative BED dose, which is the sum of external midline BED and HDR-ICBT point A BED, ranged from 62.0 to 121.9 Gy{sub 10} (median 93.0) for tumors and from 93.6 to 187.3 Gy{sub 3} (median 137.6) for late responding tissues. The median cumulative values of actual rectal (R-BED Gy{sub 3}) and bladder point BED (V-BED Gy{sub 3}) were 118.7 Gy{sub 3} (range 48.8 {approx} 265.2) and 126.1 Gy{sub 3} (range: 54.9{approx} 267.5), respectively. MD-BED Gy{sub 3} showed a good correlation with rectal ({rho} =0.003), but not with bladder complications ({rho} = 0.095), R-BED Gy{sub 3} had a very strong association ({rho} = <0.0001), and was more predictive of rectal complications than A-BED Gy{sub 3}, B-BED Gy{sub 3} also showed significance in the prediction of bladder complications in a trend test ({rho} = 0.0298). No statistically significant dose-response relationship for pelvic control was observed. The Sandwich and Continuous techniques, which differ according to when the ICR was inserted during the EBRT and due to the physicians preference, showed no differences in the local control and complication rates; there were also no differences in the 3 vs. 5 Gy fraction size of HDR-ICBT. The main reasons optimal dose-fractionation guidelines are not easily established is due to the absence of a dose-response relationship for tumor control as a result of the high-dose gradient of HDR-ICBT, individual differences in tumor responses to radiation therapy and the complexity of affecting factors. Therefore, in our opinion, there is a necessity f

Cho, Jae Ho; Kim, Hyun Chang; Suh, Chang Ok [Yonsei University Medical School, Seoul (Korea, Republic of)] (and others)

2005-09-15

172

Quantitative measurements of the changes in protein thiols in cervical intraepithelial neoplasia and in carcinoma of the human uterine cervix provide evidence for the existence of a biochemical field effect.  

Science.gov (United States)

Quantitative micromethods have been used for measuring reactive protein thiols (PSHr), total reactive protein sulfur (TRPS), total protein thiols (PSHt), and protein disulfides (PDS) in fixed frozen sections of human uterine cervix. PSHr and TRPS were stained using 2,2'-dihydroxy-6,6'-dinaphthyl disulfide; PSHt and PDS were stained using mercurochrome methods. Microspectrophotometric measurements were made on the stained sections using a microdensitometer with associated data processing; the results obtained for areas of epithelium and stroma were converted to absorbance values per micron 2. Samples of uterine cervix that were diagnosed as containing cervical intraepithelial neoplasia (CIN) I-III or carcinoma were examined and compared with samples of normal uterine cervix. Measurements were made not only on identified lesions but also on apparently normal tissue obtained from the same cervix. Epithelial/stroma ratios (E/S) were calculated for PSHr, TRPS, PSHt and PSHt + PDS; in addition, the double ratios of PSHr/TRPS and PSHt/PSHt + PDS were also calculated for E/S. The mean E/S values for PSHr and PSHt were significantly different for all types of lesion compared with control samples. The E/S ratios for apparently normal tissue obtained from cervices with CIN or carcinoma were also significantly different compared with corresponding control values, indicating a field effect. There was a considerable degree of overlap between individual values in the control groups versus those obtained with each type of lesion. The corresponding mean E/S values for TRPS and for PSHt + PDS in the samples containing lesions were not significantly different from control means except for the group containing CaCx. However, the mean values for the double ratios (PSHr/TRPS and PSHt/PSHt + PDS) were significantly different in the groups containing lesions compared with the controls. Moreover, apparently normal tissue obtained from cervices containing CIN or carcinoma had different mean values compared with the controls, confirming the existence of a field effect. The degree of overlap of individual values in the lesion groups compared with the control values was much less with double ratio values than previously noted for single ratio values. In consequence, the double ratio measurements clearly discriminated CIN I + II and CIN-III from controls. Our data show that CIN is associated with marked changes in tissue protein thiols and disulfides and that these differences extend to neighboring apparently normal tissue indicative of a field effect. PMID:2208130

Benedetto, C; Bajardi, F; Ghiringhello, B; Marozio, L; Nöhammer, G; Phitakpraiwan, P; Rojanapo, W; Schauenstein, E; Slater, T F

1990-10-15

173

Extreme cervical elongation  

OpenAIRE

Uterine prolapse is a condition which has commonly affected women of all times. The problem of genital prolapse and its remedies is described in the oldest medical literature, the Egyptian Papyri. The normal length of the cervix is about 2.5 cm. The vaginal and supravaginal parts are of equal length. The elongation may affect either part of the cervix. The length of the uterocervical canal is measured by introduction of the uterine sound. Cervical elongation plays an important role in decidin...

Pb, Hiremath; Nidhi Bansal; Reshma Hiremath

2014-01-01

174

Micronúcleos em células do colo uterino em mulheres HIV+ segundo sua condição de imunidade / Micronuclei in uterine cervical cells of women HIV+ according to immunocompetence markers  

Scientific Electronic Library Online (English)

Full Text Available OBJETIVO: investigar a micronucleação (MN) em células esfoliadas do colo uterino de mulheres HIV+ observando as condições de imunidade aferidas pelos níveis de linfócitos CD4+ e da carga viral para o HIV (CV). MÉTODOS: foram obtidas coletas citológicas da junção escamocolunar de 23 pacientes HIV+ de [...] Ambulatório de DST/AIDS. O grupo controle foi composto por mulheres assintomáticas do Ambulatório de Prevenção de Câncer Ginecológico do mesmo serviço. O material foi submetido a processamento citológico para leitura em microscopia de luz, com objetiva de imersão em 2.000 células por paciente. Para avaliação da condição imunitária das pacientes HIV+ investigamos os níveis de linfócitos CD4+ e CV. A análise estatística dos resultados se fez com os testes do ?2 e Kolmogorov-Smirnov. RESULTADOS: vinte e três pacientes compuseram o grupo de mulheres HIV+ e 19 formaram o grupo controle. Em todas as pacientes HIV+ e em 84,2% do grupo controle detectamos MN. Dezessete pacientes HIV+ (73,9%) tiveram mais de 7 MN. No grupo controle tivemos apenas 1 caso (5,2%) com mais de 7 MN. Houve tendência na associação de maiores quantidades de MN em mulheres com baixos níveis de linfócitos CD4+ e maiores níveis de CV, sem caracterizar correlação estatística. CONCLUSÕES: pacientes HIV+ em fase de AIDS têm maior ocorrência de MN que o grupo controle e, também, a frequência com que são detectados MN parece estar associada a piores condições clínicas da imunossupressão. Abstract in english PURPOSE: to investigate the micronucleation (MN) of exfoliated cells from the uterine cervix of HIV+ women according to immunocompetence status. We investigated the clinical conditions of immunocompetence by analyzing the levels of CD4+ lymphocytes and viral count for HIV (VC). METHODS: biological m [...] aterial was collected from 23 HIV+ patients whose cervical oncologic cytology results were negative. They were patients from the STD/AIDS-FCMS-PUCSP who underwent a cytobrush collection in the squamous columnar junction. Similar material was obtained from 19 healthy control women. The material, about 2000 cells per patient, was processed for cytology using light microscopy and an immersion objective. To analyze the immunological status of HIV+ patients we used CD4+ count and VC. Statistical analysis was performed using the ?2 and Kolmorogov-Smirnov tests. RESULTS: twenty-three pacients composed the group of HIV+ women and 19 composed the control group. We found micronuclei (MN) in all HIV+ patients and in 84.2% of the control group. In 17 73.9% of the HIV+ patients and in 5.2% of the control group we found more than 7 MN cells. MN tended to occur more among women with poorer immunological status in the HIV+ group. CONCLUSIONS: HIV+ patients in the AIDS phase have a higher prevalence of micronucleated cells, as opposed to a control group. Also, the frequency of MN was associated with worse conditions of immunosuppression.

Camila Figueira, Mendes; Gildo, Gardinalli Filho; Renato Marinho, Furoni; Luís Vicente Vélez, Miranda; Júlio, Boschini Filho; Luiz Ferraz De, Sampaio Neto.

2011-10-01

175

Evaluación del seguimiento de mujeres con cáncer cervicouterino en dos policlínicos. Pinar del Río / Follow-up assessment of women suffering from cervical uterine cancer in two polyclinics, Pinar del Rio  

Scientific Electronic Library Online (English)

Full Text Available Introducción: A pesar de contar con un programa de detección precoz del cáncer cervicouterino de larga duración aún no se logran los resultados esperados. Objetivo: Caracterizar a las pacientes con cáncer invasor del cuello uterino en dos áreas de salud de Pinar del Río en el quinquenio 2003-2007. M [...] aterial y Método: Estudio observacional, transversal, de cohorte, retrospectivo de mujeres de cualquier edad con diagnóstico de cáncer cervicouterino invasor. La información de las pacientes se tomó de los registros automatizados de las lesiones de cuello uterino de la consulta provincial de Patología de Cuello, del Provincial de Cáncer (Dirección Provincial de Salud), y del de Mortalidad General (Dirección Provincial de Salud) así como de las historias clínicas de la Unidad Oncológica Provincial. Entre las variables estudiadas estuvieron si procedían o no del programa, edad, estadio clínico, tratamiento recibido, incidencia anual y el promedio en la etapa, la mortalidad y la letalidad. Resultados: Se encontró que el 70,6% de casos no se detectó por programa. La tasa de incidencia promedio fue 29.5 por 100000 mujeres de 15 años y más. Todas las pacientes recibieron el tratamiento oncoespecífico según estadio clínico. Las mayores tasas de mortalidad se encontraron en las pacientes en estadio IIIB al diagnóstico. Conclusiones: Se detectan fallas en la Atención Primaria de Salud, por falta de detección. Las tasas de incidencia de esta enfermedad no se han logrado disminuir. Y se siguen diagnosticando casos en estadios avanzados de la enfermedad, lo que acorta la sobrevida de estas pacientes. Abstract in english Introduction: Despite of having a program, for a long time, to the early detection of cervical uterine cancer, the results expected are not as far achieved. Objective: to characterize the patients suffering from invasive cervical uterine cancer in two health areas in Pinar del Rio province throughou [...] t five years (2003-2007). Material and Methods: observational, cross-sectional, cohort, retrospective study including women at every age with invasive cervical-uterine cancer. The information concerning the patients was collected from the automated records of cervical uterine at the provincial office for cervix pathology treatment (Provincial Public Health Direction), general death rate (Provincial Public Health Direction) and from the clinical histories of the Provincial Cancer Unit. Among the variables studied were: coming or not from the program, age, clinical stage, treatment followed, and annual incidence, together with the average of mortality and lethality considering the clinical stages. Results: 70,6% of the cases were not detected by the program. The average incidence rate was 29.5 per 10 0000 women from 15 years old or older. All patients underwent to a specific cancer treatment according to the clinical stage. The greatest mortality rates were found in patients presenting IIIB stage at diagnosis. Conclusion: errors were observed in Primary Health Care leading to deficiencies in the early detection of this type cancer. The incidence rates of this disease have not diminished; cases suffering from advanced stages of the disease are still detected, shortening the survival rate of these patients.

José Guillermo, Sanabria Negrín; Inalvis de la Caridad, Cruz Hernández; Leonardo, Oriolo Pérez; Miguel Angel, Pérez Herrera; Beatriz, Valdés Abreu.

2012-06-01

176

6 Common Cancers - Gynecologic Cancers Cervical, Endometrial, and Ovarian  

Science.gov (United States)

... 6 Common Cancers - Gynecologic Cancers Cervical, Endometrial, and Ovarian Past Issues / Spring 2007 Table of Contents For ... turn Javascript on. Gynecologic Cancers Cervical, Endometrial, and Ovarian NCI estimates that endometrial, or uterine, cancer will ...

177

Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile / Detection and genotyping of human papillomavirus in biopsies of uterine cervical adenocarcinoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish [...] Abstract in english Background: The genotyping of Human Papillomavirus (HPV) will improve knowledge about the local epidemiological association of this virus with adenocarcinoma. Aim: To determine the frequency of HPV genotypes in biopsies of women with uterine cervical adenocarcinoma in a geographic region of Chile. M [...] aterials and Methods: Forty-one cervical biopsies with a pathological diagnosis of adenocarcinoma, corresponding to all women diagnosed with this cancer between 2002 and 2004, were analyzed. Viral gene Ll was amplified by PCRfor viral detection. HPV genotyping was carried out by a Reverse Line Blot technique. Results: Seventy one percent of biopsies were positive for HPV. The most common genotypes found were HPV 16 (61%), followed by HPV 18 (19.5%). Eighty seven percent of biopsies had a single HPV infection. Three patients had a multiple HPV infection. All of the latter were infected by HPV 16, associated with other three viral genotypes (45, 52 and 66). No low-risk HPV genotypes were found. Conclusions: In this sample of biopsies, there was a high prevelence of HPV 16 and a low prevalence of HPV 18, which historically has been related to adenocarcinoma. The genotypes found correspond to those described in South America.

Priscilla, Brebi M; Carmen Gloria, Ili G; Jaime, López M; Patricia, García M; Angélica, Melo A; Sonia, Montenegro H; Pamela, Leal R; Pablo, Guzmán G; Juan Carlos, Roa S.

2009-03-01

178

Uterine Fibroid Embolization (UFE)  

Science.gov (United States)

Uterine Fibroid Embolization (UFE) Play Video Clip (00:02:13) Your Radiologist Explains Uterine Fibroid Embolization (UFE) What ... limitations of Uterine Fibroid Embolization (UFE)? What is Uterine Fibroid Embolization (UFE)? Uterine fibroid embolization (UFE) is a ...

179

[Treatment of cervical cancer].  

Science.gov (United States)

The treatment of uterine cervical cancer evolved the last past twenty years. The management of early stages cervical cancer is based on surgery +/- after an initial brachytherapy in order to increase loco-regional control. A conservative treatment preserving uterine and ovarian functions is sometimes possible for young patients < 40 years old wishing to conceive. This strategy allows pregnancies with low recurrence rate. Finally, the use of the sentinel lymph node staging should be validated within the next few years. The treatment of locally advanced stages is based on concomitant chemoradiation therapy, which allows obtaining an important complete tumour response rate (90%). Thereafter, the irradiation modalities will depend on the para-aortic lymph nodes status diagnosed by PET-computed tomography +/- staging laparoscopic para-aortic lymphadenectomy. The use of completion surgery may be indicated in case of cervical residual disease and has to be balanced with its specific morbidity. All the decisions are made during a multidisciplinary tumour board. PMID:25090765

Touboul, Cyril; Skalli, Dounia; Guillo, Eric; Martin, Michel; Mallaurie, Emmanuelle; Mansouri, Dhouha; Abd Al Samad, Issam; Chabi, Naima; Hospitel, Sylvie; Koskas, Martin; Haddad, Bassam

2014-06-01

180

Multivariate discriminant analysis of normal, intraepithelial neoplasia and human papillomavirus infection of the uterine cervix samples  

OpenAIRE

The present investigation studies the role of multivariate statistical methods on quantitative histopathological features of cells in uterine cervix epithelium to discriminate between normal and abnormal uterine cervix samples. 143 histological specimens were included in the study involving normal cervix, cervical intraepithelial neoplasia (CIN) lesions and cervical human papillomavirus (HPV) infection with and without CIN (condyloma-CIN and condyloma-NCIN ...

Artacho-perula, E.; Roldan-villalobos, R.; Salas-molina, J.; Vaamonde-lemos, R.

1994-01-01

181

Magnetic resonance imaging of cancer of uterine cervix and body. Preliminary study in 9 cases of body cancer and 20 of cervical cancer  

International Nuclear Information System (INIS)

We studied nine cases of endometrial carcinoma and twenty of cervix carcinoma. Correlation with histology is made after curietherapy in 8 cases of endometrial carcinoma. Tumor is not always seen and particularly when there is no mass effect on macroscopic examination. Myometral invasion is not seen with accuracy: the interruption of junctional zone is not a good sign. The cervix tumors are well seen on T2 sequences before any treatment. There extra uterine extension is difficult to appreciate. The best results of RMI were in the follow-up after radiotherapy. Therefore it appears actually to us the best indication of RMI

182

Preliminary estimation of treatment effect on uterine cervical squamous cell carcinoma in terms of tumor regression rate. Comparison between chemoradiotherapy and radiotherapy alone  

International Nuclear Information System (INIS)

We preliminarily estimated the treatment effect on cervical cancer in terms of the tumor regression rate (TRR) achieved with chemoradiotherapy and radiotherapy alone. The study included cervical squamous cell carcinomas treated by radiotherapy alone (n=45) or chemoradiotherapy (concurrent once-a-week cisplatin 30 mg/m2, n=13). Tumors were measured three-dimensionally on pre- and mid-treatment magnetic resonance images. TRR was defined as the slope of the exponential regression curve of tumor volume (day-1) on the assumption that tumors regressed exponentially with time. TRR ranged widely (0.004-0.090 day-1) and did not significantly differ between treatment with chemoradiotherapy (median, 0.032 day-1) and with radiotherapy alone (median, 0.024 day-1) (p=0.361). TRR>0.05 day-1 was seen in four chemoradiotherapy tumors (30.8%) and in six radiotherapy-alone tumors (15.0%) (p=0.207), whereas TRR-1 was seen in no chemoradiotherapy tumors (0.0%) and in five radiotherapy-alone tumors (11.1%) (p=0.180). TRR for tumors >5.0 cm in diameter was greater with chemoradiotherapy (n=5) than with radiotherapy alone (n=12) (p=0.065). Although the difference did not reach a statistically significant level, our TRR data suggest that concurrent chemotherapy heightens the radioresponse of large-size cervical cancer. (author)

183

Preliminary Experience with Locoregional Intraarterial Chemotherapy of Uterine Cervical or Endometrial Cancer Using the Peripheral Implantable Port System (PIPSTM): A Feasibility Study  

International Nuclear Information System (INIS)

The purpose of this study was to assess the suitability of a percutaneously implantable catheter port system (PIPS)for repeated intraarterial locoregional chemotherapy (ILC) for cervical and endometrial carcinoma. In 30 patients with advanced, recurrent, or high-risk cervical (n 23) or endometrial(n = 7) carcinoma, PIPS for ILC was implanted via a femoral access, the catheter localized in the infrarenal abdominal aorta. Chemotherapy was performed adjuvantly after surgery(n = 14) or neo-adjuvantly to enable surgery, or for palliation (n = 16). Port implantation, catheter placement, and repeated port puncture was uneventful in all patients.Complications included catheter dislocation (n = 1),catheter thrombosis (n = 2), subcutaneous infection(n = 1), port-bed skin atrophy (n = 1),requiring port explantation in 3 patients. At 2 years follow-up,complete remission was observed in 7/14 patients with adjuvant chemotherapy, partial remission in 3/14. Successful down-staging could be achieved in 4/8 patients with neo-adjuvant chemotherapy. The PIPS is suitable for repeated ILC which may be a valuable method for pre- and post-surgical therapy of advanced or high-risk cervical and endometrial cancer, for adjuvant chemotherapy as well as neo-adjuvantly for down-staging, or for palliation

184

Uterine sarcoidosis: a rare extrapulmonary site of sarcoidosis.  

Science.gov (United States)

Sarcoidosis is a multisystem disease which is most commonly manifested in the pulmonary system. However, extrapulmonary manifestations have also been frequently reported. Isolated occurrence of sarcoidosis in the genital system is rare and poses a diagnostic and therapeutic dilemma. Uterine sarcoidosis can present with cervical erosions, endometrial polypoid lesions, and recurrent serometra. In majority of cases, it is diagnosed by endometrial curettage, but it has also been detected by examination of hysterectomy, polypectomy, and autopsy specimens. Nonnecrotizing granulomas are the characteristic pathologic finding of sarcoidosis. However, many infectious and noninfectious etiologies including certain neoplasms can produce similar granulomatous reactions in the female genital tract. These conditions affect the female genital tract more commonly than sarcoidosis, and therefore it is important to rule out these conditions first before making a diagnosis of sarcoidosis. Treatment of sarcoidosis is different from treating these other conditions and the most commonly used systemic or local corticosteroids can be hazardous if the underlying cause is infection. In this case report, the clinical presentation, histopathology, clinical course, and treatment of a patient with isolated uterine sarcoidosis are described, and a brief literature review of sarcoidosis of the female genital tract is provided. PMID:23762732

Marak, Creticus P; Alappan, Narendrakumar; Chopra, Amit; Dorokhova, Olena; Sinha, Sumita; Guddati, Achuta K

2013-01-01

185

Lesões precursoras do câncer cervicouterino: evolução histórica e subsídios para consulta de enfermagem ginecológica Lesiones precursoras del cáncer cervical-útero: evolución histórica consolidando la consulta de enfermería ginecológica Cervical-uterine cancer precursor lesions: historical evolution supporting the gynecological nursing consultation  

Directory of Open Access Journals (Sweden)

Full Text Available Estudo emergido de recorte de dissertação de mestrado, ilustrando a evolução histórica das lesões precursoras do câncer cervicouterino (LPCCU. Trata-se da história das LPCCU, delineando a relevância do conhecimento para prática do enfermeiro na área da saúde da mulher. O conceito de LPCCU inicia-se a partir do século XIX, dando início aos estudos das células alteradas. Objetivo: descrever as diversas fases da evolução histórica das alterações cervicais. Estudo qualitativo, descritivo-analítico, recorte temporal no período de 1940 a 2008. Dados levantados mediante bibliografia de fonte primária e recurso BIREME. Pontuaram-se as classificações que já existiram, destacando a Nomenclatura Brasileira, importante para corresponder às necessidades e o perfil da saúde das mulheres do Brasil. Este estudo é o ponto de partida para respaldar as práticas de consulta de enfermagem ginecológica com abordagens educativas, contemplando a população feminina em ações preventivas e incentivo ao tratamento.Estudio emergido de recorte de disertación de máster, ilustrando la evolución histórica de las lesiones precursoras del cáncer cervical-uterino (LPCCU. Se trata de la historia de las LPCCU, delineando la relevancia del conocimiento para la práctica del enfermero en cuidados en la salud de la mujer. El concepto de LPCCU se inicia a partir del siglo XIX, empezando los estudios de las células alteradas. Como objetivo: describir las diversas fases históricas de las alteraciones cervicales. Estudio cualitativo, descriptivo-analítico, recorte temporal en el período de 1940 hasta 2008. Datos acrecentados mediante bibliografía de fuente primaria y recurso BIREME. Se puntuó las diferentes clasificaciones que ya existieron, conde destaque para la nomenclatura brasileña, importante para corresponder a las necesidades y el perfil de la salud de las mujeres del Brasil. Esto estudio es el ponto de partida para respaldar las prácticas de consulta de enfermería ginecológica con abordajes educativas, contemplando la población femenina en acciones preventivas y incentivo al tratamiento.Study emerged from an article of the master degree that illustrates the phases of the historical evolution of the precursor lesions of the cervical-uterine cancer. Thus, it is a question of the history about, delineating the relevance of this knowledge for the nurse's practice in care in the woman's health. The precursor lesions concept of the cervical-uterine cancer, initiates itself from the XIX century, beginning with studies of the cells altered. It had as objective: describe the diverse historical phases of the cervical-uterine cancer. A qualitative, descriptive-analytical study, using time cutting in the period of 1940 to 2008. The data were raised by means of bibliographical reference as primary spring and about the resource BIREME, By means of this study was possible to score the different classifications that already existed, highlighting the Brazilian Nomenclature was important to correspond the needs and the profile of the health of the women of Brazil. This study is the starting point to support the gynecological nursing consultation practices with educational approaches, contemplating the female population in preventive actions and incentive to the treatment.

Maria Cristina de Melo Pessanha Carvalho

2010-09-01

186

Lesões precursoras do câncer cervicouterino: evolução histórica e subsídios para consulta de enfermagem ginecológica / Cervical-uterine cancer precursor lesions: historical evolution supporting the gynecological nursing consultation / Lesiones precursoras del cáncer cervical-útero: evolución histórica consolidando la consulta de enfermería ginecológica  

Scientific Electronic Library Online (English)

Full Text Available Estudo emergido de recorte de dissertação de mestrado, ilustrando a evolução histórica das lesões precursoras do câncer cervicouterino (LPCCU). Trata-se da história das LPCCU, delineando a relevância do conhecimento para prática do enfermeiro na área da saúde da mulher. O conceito de LPCCU inicia-se [...] a partir do século XIX, dando início aos estudos das células alteradas. Objetivo: descrever as diversas fases da evolução histórica das alterações cervicais. Estudo qualitativo, descritivo-analítico, recorte temporal no período de 1940 a 2008. Dados levantados mediante bibliografia de fonte primária e recurso BIREME. Pontuaram-se as classificações que já existiram, destacando a Nomenclatura Brasileira, importante para corresponder às necessidades e o perfil da saúde das mulheres do Brasil. Este estudo é o ponto de partida para respaldar as práticas de consulta de enfermagem ginecológica com abordagens educativas, contemplando a população feminina em ações preventivas e incentivo ao tratamento. Abstract in spanish Estudio emergido de recorte de disertación de máster, ilustrando la evolución histórica de las lesiones precursoras del cáncer cervical-uterino (LPCCU). Se trata de la historia de las LPCCU, delineando la relevancia del conocimiento para la práctica del enfermero en cuidados en la salud de la mujer. [...] El concepto de LPCCU se inicia a partir del siglo XIX, empezando los estudios de las células alteradas. Como objetivo: describir las diversas fases históricas de las alteraciones cervicales. Estudio cualitativo, descriptivo-analítico, recorte temporal en el período de 1940 hasta 2008. Datos acrecentados mediante bibliografía de fuente primaria y recurso BIREME. Se puntuó las diferentes clasificaciones que ya existieron, conde destaque para la nomenclatura brasileña, importante para corresponder a las necesidades y el perfil de la salud de las mujeres del Brasil. Esto estudio es el ponto de partida para respaldar las prácticas de consulta de enfermería ginecológica con abordajes educativas, contemplando la población femenina en acciones preventivas y incentivo al tratamiento. Abstract in english Study emerged from an article of the master degree that illustrates the phases of the historical evolution of the precursor lesions of the cervical-uterine cancer. Thus, it is a question of the history about, delineating the relevance of this knowledge for the nurse's practice in care in the woman's [...] health. The precursor lesions concept of the cervical-uterine cancer, initiates itself from the XIX century, beginning with studies of the cells altered. It had as objective: describe the diverse historical phases of the cervical-uterine cancer. A qualitative, descriptive-analytical study, using time cutting in the period of 1940 to 2008. The data were raised by means of bibliographical reference as primary spring and about the resource BIREME, By means of this study was possible to score the different classifications that already existed, highlighting the Brazilian Nomenclature was important to correspond the needs and the profile of the health of the women of Brazil. This study is the starting point to support the gynecological nursing consultation practices with educational approaches, contemplating the female population in preventive actions and incentive to the treatment.

Maria Cristina de Melo Pessanha, Carvalho; Ana Beatriz Azevedo, Queiroz.

2010-09-01

187

Uterine Cancer  

Science.gov (United States)

... is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, the lining of the uterus. This type of cancer is sometimes called endometrial cancer. The symptoms of ...

188

Laparoscopia quirúrgica en cáncer de cuello uterino, en el Hospital IV Huancayo EsSalud / Surgical laparoscopy in uterine cervical cancer at EsSalud Huancayo Hospital  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Introducción: El cáncer de cérvix es la causa más frecuente de muerte en la sierra central peruana. El tratamiento quirúrgico (histerectomía total laparoscópica e histerectomía radical más linfadenectomía pélvica laparoscópica) es el recurso terapéutico mayormente curativo en los estadios iníciales [...] (Ia1, Ia2 y Ib1). Hace un año en el Servicio de Ginecología del Hospital IV Huancayo iniciamos el tratamiento quirúrgico laparoscópico en estos estadios. Objetivos: Revisar los resultados de histerectomía laparoscópica en cáncer microinvasivo de cuello uterino. Diseño: Estudio retrospectivo. Institución: Servicio de Ginecología, Hospital IV Huancayo, EsSalud, Junín, Perú. Pacientes: Doce mujeres sometidas a histerectomía laparoscópica por carcinoma microinvasivo de cérvix. Intervenciones: En seis mujeres con diagnóstico preoperatorio de cáncer de cérvix por conización cervical y estadio clínico Ia1 se les realizó histerectomía laparoscópica, con un tiempo operatorio de 59,16 minutos y tiempo de estancia hospitalaria de 4,1 días. A otras seis mujeres con estadio clínico Ia2-Ib1 se les realizó histerectomía radical más linfadenectomía pélvica laparoscópica, con un tiempo operatorio de 3 horas 58 minutos y tiempo de estancia hospitalaria de 10,1 días. Principales medidas de resultados: Curación clínica. Resultados: Todos los diagnósticos fueron confirmados con la pieza operatoria, y todas las pacientes están teóricamente curadas (márgenes libres, ganglios negativos); una paciente presentó complicaciones, requiriendo estancia prolongada (8,3%). Conclusiones: La histerectomía total laparoscópica y la histerectomía radical más linfadenectomía pélvica laparoscópica pueden ser realizadas de manera más rápida y radical con respecto a la histerectomía convencional por laparotomía. Ambas son intervenciones factibles y seguras, que pueden garantizar la curación en el carcinoma microinvasivo de cuello uterino. Abstract in english Introduction: Cervical cancer is the most common cause of death in Peruvian central highlands. Surgical treatment (hysterectomy and total laparoscopic radical hysterectomy plus pelvic lymphadenectomy) is the best therapeutic resource in the early cancer stage (IA1, IA2 and IB1). One year ago we star [...] ted laparoscopic surgical treatment in these stages at Hospital IV Huancayo Gynecology Department. Objectives: To review outcomes of laparoscopic hysterectomy for microinvasive cervical cancer. Design: Retrospective study. Setting: Gynecology Service, Hospital IV Huancayo, EsSalud, Junin, Peru. Patients: Twelve women subjected to laparoscopic hysterectomy for cervical microinvasive carcinoma. Interventions: Six women with preoperative diagnosis by cervical conization and clinical stage IA1 underwent laparoscopic hysterectomy with 59.16 minutes operative time and 4.1 days hospital stay. Other six women with clinical stage Ia2-Ib1 underwent laparoscopic radical hysterectomy plus pelvic lymphadenectomy with operative time 3 hours and 58 minutes, and hospital stay of 10.1 days. Main outcome measures: Clinical cancer cure. Results: All diagnoses were confirmed by the surgical specimen and all were theoretically cured (negative margins, negative lymph nodes); one patient had complications that required prolonged stay (8.3%). Conclusions: Total laparoscopic hysterectomy and laparoscopic radical hysterectomy plus pelvic lymphadenectomy can be performed faster and more radically compared with conventional laparotomy. Both are feasible and safe interventions that ensure cure in microinvasive cervical carcinoma.

Ernesto, Molina-Loza; Carlos, Altez-Navarro; Gregorio, Ortiz-Lorenzo.

189

Impact of curie-therapy timing in the treatment of cervical cancer; Impact du timing de la curietherapie dans le traitement du cancer du col uterin  

Energy Technology Data Exchange (ETDEWEB)

Curie-therapy conventionally comes before surgery in the treatment of cervical cancer, either alone or after a concomitant chemotherapy. The authors report a study of the impact of a reverse sequence (surgery before curie-therapy) on the exeresis quality and on the evolution of operable tumours. Among women treated between 2004 and 2009, 40 have been identified who had surgery before curie-therapy. Ages, tumour stages, average doses, and treatment procedures are discussed. The notably high rate of vaginal sections could be reduced or avoided by using the conventional protocol (curie-therapy before surgery). Short communication

Kochbati, L.; Bouzid, N.; Saidi, I.; Nasr, C.; Messai, T.; Hentati, D.; Gargouri, W.; Besbes, M.; Maalej, M. [Service de radiotherapie, institut Salah-Azaiz, Tunis (Tunisia)

2011-10-15

190

The Reserve Cell in the Uterine Cervix: aspects of development, differentiation and diagnosis  

OpenAIRE

Carcinoma of the uterine cervix is worldwide the second most common cancer in women1. It has been approximately 150 years since the first description of uterine cervical carcinoma, a century since the description of its precursor lesions2, and half a century since the introduction of the method proposed by Papanicolaou3 for detecting cervical neoplasms by cytologic screening. In time investigators have proposed a multitude of histologic and cytologic terms for cervical precurso...

Muyden-martens, J. E.

2008-01-01

191

Prevalence of micronuclei in exfoliated uterine cervical cells from patients with risk factors for cervical cancer / Prevalência de micronúcleos em células esfoliativas do colo uterino de pacientes com fatores de risco para o câncer de colo uterino  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese CONTEXTO E OBJETIVO: O câncer do colo uterino é uma das mais freqüentes neoplasias na mulher. O exame de Papanicolaou é o método mais comum e econômico para rastreamento. As células esfoliativas epiteliais podem ser úteis para o monitoramento de pacientes expostas a fatores de risco para o câncer. O [...] objetivo foi analisar a prevalência de micronúcleos em células esfoliativas da mucosa cervical uterina e associar com fatores de risco para o câncer de colo uterino. TIPO DE ESTUDO E LOCAL: Estudo transversal analítico, no Instituto de Pesquisa em Oncologia (IPON). MÉTODOS: Células esfoliativas do colo uterino foram obtidas de 101 pacientes ambulatoriais entre setembro/2004 e novembro/2005. As células foram coletadas usando espátula de Ayre e transferidas para um tubo de ensaio com soro fisiológico 0,9% para o teste do micronúcleo. Informações obtidas das pacientes foram: idade, hábitos (fumo e número de parceiros sexuais), métodos contraceptivos, história de doença sexualmente transmissível e uso de terapia hormonal. Células foram analisadas com magnificação de 1000 X e os micronúcleos contados em 1.000 células epiteliais por paciente. RESULTADOS: A comparação do grupo de pacientes fumantes ativas (7,9 ± 7,8) e passivas (7,2 ± 10,6) versus não fumantes (3,7 ± 5,1); alcoolismo e não alcoolismo (7,8 ± 1,4 e 6,9 ± 10,1); citologia inflamatória e citologia normal (10,7 ± 10,5 e 1,3 ± 1,7); neoplasia intraepitelial cervical (NIC) I, II e III e a ausência de NIC, respectivamente, (4,3 ± 4,3; 10,6 ± 5,3; 22,7 ± 11,9 e 1.3 ± 1.4) mostrou maior prevalência de micronúcleos (P Abstract in english CONTEXT AND OBJECTIVE: Pap smears are the most common and inexpensive screening method for cervical cancer. We analyzed micronucleus prevalence in exfoliated cervical mucosa cells, to investigate associations between increased numbers of micronuclei and risk factors for cervical cancer. DESIGN AND S [...] ETTING: Analytical cross-sectional study, at Instituto de Pesquisa em Oncologia (IPON). METHODS: Exfoliated cervical cells were obtained from 101 patients between September 2004 and November 2005. Patients' ages, habits (passive or active smoking, alcoholism and numbers of sexual partners), age at first sexual intercourse, contraceptive methods used, histories of sexually transmitted diseases, use of hormone replacement therapy, numbers of pregnancies and abortions, inflammatory cytology and cervical intraepithelial neoplasia (CIN) were obtained. Cells were collected using Ayre spatulas, transferred to vials containing 0.9% saline solution for micronucleus tests and analyzed at 1000x magnification. The number of micronuclei in 1,000 epithelial cells per patient sample was counted. RESULTS: Comparisons between groups with active (7.9 ± 7.8) and passive (7.2 ± 10.6) smoking versus no smoking (3.7 ± 5.1); with/without alcoholism (7.8 ± 1.4 and 6.9 ± 10.1); with/without inflammatory cytology (10.7 ± 10.5 and 1.3 ± 1.7); and with CIN I, II and III and no CIN (respectively 4.3 ± 4.3, 10.6 ± 5.3, 22.7 ± 11.9 and 1.3 ± 1.4) found elevated micronucleus prevalence (P

Lízia Maria Franco dos Reis, Campos; Francisca da Luz, Dias; Lusânia Maria Greggi, Antunes; Eddie Fernando Candido, Murta.

2008-11-01

192

In vivo measurements of uterine cavities in 795 women of fertile age  

OpenAIRE

The uterine sound length, the functional length of the cervix including the zone of internal cervical os and the fundus transversal were determined in 795 fertile women in vivo using a measuring device, the Cavimeter. The functional cavity length was calculated by subtracting the functional length of the cervix from the uterine sound length. With growing parity, the uterine length and width increase, but with advance in age, the uterine cavity changes are not so distinct. The wide ran...

Haspels, A. A.; Tadesse, E.; Kurz, K. H.

1984-01-01

193

Uterine caliper and depth gauge  

Energy Technology Data Exchange (ETDEWEB)

A uterine caliper and sound consisting of an elongated body having outwardly biased resilient caliper wings and a spring-loaded slidable cervical stop. A slide on the body is operatively connected to the wings by a monofilament and operates with respect to a first scale on the body as a width indicator. A rod extending longitudinally on the body is connected to the cervical stop and cooperates with a second scale on the body as a depth indicator. The instrument can be positioned to measure the distance from the outer cervical ostium to the fundus, as read on said second scale. The wings may be allowed to open by moving the slide, and when the wings engage the utero-tubal junctions, the width may be read on said first scale. By adjustment of the caliper wings the instrument may be retracted until the resistance of the inner ostium of the cervix is felt, enabling the length of the cervical canal to be read directly by the position of the longitudinal indicator rod with respect to said second scale. The instrument may be employed to measure the width of the uterine cavity at any position between the inner ostium of the cervix and the fundus.

King, Loyd L. (Benton City, WA); Wheeler, Robert G. (Richland, WA); Fish, Thomas M. (Kennewick, WA)

1977-01-01

194

Efficacy of Cone Biopsy of the Uterine Cervix during Frozen Section for the Evaluation of Cervical High Grade Intraepithelial Neoplasia (CIN II-III  

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Full Text Available Introduction & Objectives: This study was performed to determine the role of frozen section examination (FSE of the cone specimen in the evaluation of the resection margin status and to rule out invasion in patients with high-grade cervical intraepithelial neoplasia.Materials & Methods: Twenty patients with high grade intraepithelial neoplasia undergoing conization biopsy and frozen section examination were cross- sectionally studied from March 2008 until September 2009.The results of permanent paraffin sections were compared using FSE.Results: In this cross-sectional study, 15 out of 20 cases (75% showed the same results in frozen and permanent sections of cone biopsy specimen. Two patients out of the remaining 5 ones had higher grade of CIN in frozen section, 2 had lower grade and one was considered the same because CIN1 in FSE was normal in permanent sections.although The Paired Sample t-test showed no significant difference between the two groups of frozen and permanent section results (P-value=0.716, CI=95%. Conclusion: Frozen section evaluation of cervical cone biopsy specimens in patients with CIN II-III is accurate, efficient, and cost-effective.

V. Titidej

2010-01-01

195

Antimicrobial factors in the cervical mucus plug  

DEFF Research Database (Denmark)

The cervical mucus plug is positioned between the microbe-rich vagina and the normally sterile uterine cavity, which suggests a host defense function, but few relevant data are available. We analyzed the composition and antimicrobial activity of cervical mucus plugs.

Hein, Merete; Valore, Erika V

2002-01-01

196

Three Unique Cases of Uterine Anomaly: Atypical Müllerian Ducts Development  

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Full Text Available Uterine anomalies have different types and are classified in different ways. Here, we report three hysterosalpingographically unique cases of uterine anomalies selected from more than 30,000 cases over duration of 40 years. Case 1 is a branching out bicornuate uterus, in which the left uterine horn and cervix branch from the cervical canal. The second case is a unicornuate uterus, in which a fallopian tube without uterine cavity directly branches from this corn. The third case is a cross-shaped bicornuate uterus. Considering the embryologic development of uterus, we concluded that these three cases had abnormalities in different stages of their Müllerian ducts' development

"M. T. Meamarzadeh

2004-06-01

197

Extreme cervical elongation  

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Full Text Available Uterine prolapse is a condition which has commonly affected women of all times. The problem of genital prolapse and its remedies is described in the oldest medical literature, the Egyptian Papyri. The normal length of the cervix is about 2.5 cm. The vaginal and supravaginal parts are of equal length. The elongation may affect either part of the cervix. The length of the uterocervical canal is measured by introduction of the uterine sound. Cervical elongation plays an important role in deciding the surgical treatment. We had a case of extreme cervical elongation and we faced difficulties during the surgery. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 777-779

Hiremath PB

2014-06-01

198

Insufficiency Fractures After Pelvic Radiation Therapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG)  

International Nuclear Information System (INIS)

Purpose: To investigate pelvic insufficiency fractures (IF) after definitive pelvic radiation therapy for early-stage uterine cervical cancer, by analyzing subjects of a prospective, multi-institutional study. Materials and Methods: Between September 2004 and July 2007, 59 eligible patients were analyzed. The median age was 73 years (range, 37-84 years). The International Federation of Gynecologic Oncology and Obstetrics stages were Ib1 in 35, IIa in 12, and IIb in 12 patients. Patients were treated with the constant method, which consisted of whole-pelvic external-beam radiation therapy of 50 Gy/25 fractions and high-dose-rate intracavitary brachytherapy of 24 Gy/4 fractions without chemotherapy. After radiation therapy the patients were evaluated by both pelvic CT and pelvic MRI at 3, 6, 12, 18, and 24 months. Diagnosis of IF was made when the patients had both CT and MRI findings, neither recurrent tumor lesions nor traumatic histories. The CT findings of IF were defined as fracture lines or sclerotic linear changes in the bones, and MRI findings of IF were defined as signal intensity changes in the bones, both on T1- and T2-weighted images. Results: The median follow-up was 24 months. The 2-year pelvic IF cumulative occurrence rate was 36.9% (21 patients). Using Common Terminology Criteria for Adverse Events version 3.0, grade 1, 2, and 3 IF were seen in 12 (21%), 6 (10%), and 3 patients (5%), respectively. Sixteen patients had multiple fractures, so IF were idents had multiple fractures, so IF were identified at 44 sites. The pelvic IF were frequently seen at the sacroileal joints (32 sites, 72%). Nine patients complained of pain. All patients' pains were palliated by rest or non-narcotic analgesic drugs. Higher age (>70 years) and low body weight (<50 kg) were thought to be risk factors for pelvic IF (P=.007 and P=.013, Cox hazard test). Conclusions: Cervical cancer patients with higher age and low body weight may be at some risk for the development of pelvic IF after pelvic radiation therapy.

199

Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2)  

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Purpose: To determine the efficacy of a definitive radiotherapy protocol using high-dose-rate intracavitary brachytherapy (HDR-ICBT) with a low cumulative dose schedule in nonbulky early-stage cervical cancer patients, we conducted a prospective multi-institutional study. Methods and Materials: Eligible patients had squamous cell carcinoma of the intact uterine cervix, Federation of Gynecologic Oncology and Obstetrics (FIGO) stages Ib1, IIa, and IIb, tumor size <40 mm in diameter (assessed by T2-weighted magnetic resonance imaging), and no pelvic/para-aortic lymphadenopathy. The treatment protocol consisted of whole-pelvis external beam radiotherapy (EBRT) of 20 Gy/10 fractions, pelvic EBRT with midline block of 30 Gy/15 fractions, and HDR-ICBT of 24 Gy/4 fractions (at point A). The cumulative biologically effective dose (BED) was 62 Gy{sub 10} ({alpha}/{beta} = 10) at point A. The primary endpoint was the 2-year pelvic disease progression-free (PDPF) rate. All patients received a radiotherapy quality assurance review. Results: Between September 2004 and July 2007, 60 eligible patients were enrolled. Thirty-six patients were assessed with FIGO stage Ib1; 12 patients with stage IIa; and 12 patients with stage IIb. Median tumor diameter was 28 mm (range, 6-39 mm). Median overall treatment time was 43 days. Median follow-up was 49 months (range, 7-72 months). Seven patients developed recurrences: 3 patients had pelvic recurrences (2 central, 1 nodal), and 4 patients had distant metastases. The 2-year PDPF was 96% (95% confidence interval [CI], 92%-100%). The 2-year disease-free and overall survival rates were 90% (95% CI, 82%-98%) and 95% (95% CI, 89%-100%), respectively. The 2-year late complication rates (according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer of Grade {>=}1) were 18% (95% CI, 8%-28%) for large intestine/rectum, 4% (95% CI, 0%-8%) for small intestine, and 0% for bladder. No Grade {>=}3 cases were observed for genitourinary/gastrointestinal late complications. Conclusions: These results suggest that definitive radiotherapy using HDR-ICBT with a low cumulative dose schedule (BED, 62 Gy{sub 10} at point A) can provide excellent local control without severe toxicity in nonbulky (<4-cm) early-stage cervical cancer.

Toita, Takafumi, E-mail: b983255@med.u-ryukyu.ac.jp [Department of Radiology, Graduate School of Medical Science, University of Ryukyus, Okinawa (Japan); Kato, Shingo [Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Niibe, Yuzuru [Department of Radiology, School of Medicine, Kitasato University, Sagamihara (Japan); Ohno, Tatsuya [Gunma University Heavy Ion Medical Center, Maebashi (Japan); Kazumoto, Tomoko [Department of Radiology, Saitama Cancer Center, Saitama (Japan); Kodaira, Takeshi [Department of Radiation Oncology, Aichi Cancer Center, Nagoya (Japan); Kataoka, Masaaki [Department of Radiology, National Shikoku Cancer Center, Ehime (Japan); Shikama, Naoto [Department of Radiation Oncology, Saku Central Hospital, Saku (Japan); Kenjo, Masahiro [Department of Radiation Oncology, Graduate School of Medical Science, Hiroshima University, Hiroshima (Japan); Tokumaru, Sunao [Department of Radiology, Saga University, Saga (Japan); Yamauchi, Chikako [Department of Radiation Oncology, Shiga Medical Center for Adults, Moriyama (Japan); Suzuki, Osamu [Department of Radiation Oncology, Osaka Medical Center for Cancer, Osaka (Japan); Sakurai, Hideyuki [Proton Medical Research Center and Tsukuba University, Tsukuba (Japan); Numasaki, Hodaka; Teshima, Teruki [Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Suita, Osaka (Japan); Oguchi, Masahiko [Department of Radiation Oncology, Cancer Institute Hospital, Tokyo (Japan); Kagami, Yoshikazu [Radiation Oncology Division, National Cancer Center Hospital, Tokyo (Japan); Nakano, Takashi [Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi (Japan); Hiraoka, Masahiro [Department of Radiation Oncology and Image-applied Therapy, Kyoto University, Graduate School of Medicine, Kyoto (Japan); Mitsuhashi, Norio [Department of Radiation Oncology, Tokyo Women' s Medical University, Tokyo (Japan)

2012-01-01

200

Insufficiency Fractures After Pelvic Radiation Therapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG)  

Energy Technology Data Exchange (ETDEWEB)

Purpose: To investigate pelvic insufficiency fractures (IF) after definitive pelvic radiation therapy for early-stage uterine cervical cancer, by analyzing subjects of a prospective, multi-institutional study. Materials and Methods: Between September 2004 and July 2007, 59 eligible patients were analyzed. The median age was 73 years (range, 37-84 years). The International Federation of Gynecologic Oncology and Obstetrics stages were Ib1 in 35, IIa in 12, and IIb in 12 patients. Patients were treated with the constant method, which consisted of whole-pelvic external-beam radiation therapy of 50 Gy/25 fractions and high-dose-rate intracavitary brachytherapy of 24 Gy/4 fractions without chemotherapy. After radiation therapy the patients were evaluated by both pelvic CT and pelvic MRI at 3, 6, 12, 18, and 24 months. Diagnosis of IF was made when the patients had both CT and MRI findings, neither recurrent tumor lesions nor traumatic histories. The CT findings of IF were defined as fracture lines or sclerotic linear changes in the bones, and MRI findings of IF were defined as signal intensity changes in the bones, both on T1- and T2-weighted images. Results: The median follow-up was 24 months. The 2-year pelvic IF cumulative occurrence rate was 36.9% (21 patients). Using Common Terminology Criteria for Adverse Events version 3.0, grade 1, 2, and 3 IF were seen in 12 (21%), 6 (10%), and 3 patients (5%), respectively. Sixteen patients had multiple fractures, so IF were identified at 44 sites. The pelvic IF were frequently seen at the sacroileal joints (32 sites, 72%). Nine patients complained of pain. All patients' pains were palliated by rest or non-narcotic analgesic drugs. Higher age (>70 years) and low body weight (<50 kg) were thought to be risk factors for pelvic IF (P=.007 and P=.013, Cox hazard test). Conclusions: Cervical cancer patients with higher age and low body weight may be at some risk for the development of pelvic IF after pelvic radiation therapy.

Tokumaru, Sunao, E-mail: tokumaru@cc.saga-u.ac.jp [Department of Heavy Particle Therapy and Radiation Oncology, Saga University, Saga (Japan); Toita, Takafumi [Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa (Japan); Oguchi, Masahiko [Radiation Oncology Department, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo (Japan); Ohno, Tatsuya [Gunma University Heavy Ion Medical Center, Maebashi (Japan); Kato, Shingo [Department of Radiation Oncology, Saitama Medical University, International Medical Center, Saitama (Japan); Niibe, Yuzuru [Department of Radiology, School of Medicine, Kitasato University, Sagamihara (Japan); Kazumoto, Tomoko [Department of Radiology, Saitama Cancer Center, Saitama (Japan); Kodaira, Takeshi [Department of Radiation Oncology, Aichi Cancer Center, Nagoya (Japan); Kataoka, Masaaki [Department of Radiology, National Shikoku Cancer Center, Matsuyama (Japan); Shikama, Naoto [Department of Radiation Oncology, Saitama Medical University, International Medical Center, Saitama (Japan); Kenjo, Masahiro [Department of Radiation Oncology, Graduate School of Medical Science, Hiroshima University, Hiroshima (Japan); Yamauchi, Chikako [Department of Radiation Oncology, Shiga Medical Center for Adults, Moriyama (Japan); Suzuki, Osamu [Department of Radiation Oncology, Osaka Medical Center for Cancer, Osaka (Japan); Sakurai, Hideyuki [Proton Medical Research Center and Tsukuba University, Tuskuba (Japan); Teshima, Teruki [Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Suita (Japan); Kagami, Yoshikazu [Department of Radiology, Showa University School of Medicine, Tokyo (Japan); Nakano, Takashi [Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi (Japan); Hiraoka, Masahiro [Department of Radiation Oncology and Image-applied Therapy, Kyoto University, Graduate School of Medicine, Kyoto (Japan); and others

2012-10-01

201

Combined radiation and chemotherapy for locally advanced cervical cancer: preliminary study; Radio-chimiotherapie concomitante dans les cancers du col uterin localement avances: etude preliminaire  

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We have designed a combined treatment strategy of bifractionated split course radiotherapy (RT) and concomitant chemotherapy (CT) to try to improve the results of RT in inoperable cervical carcinoma. After evaluation, patients were submitted to further radical surgery or additional RT-CT depending on the treatment results. Between January 1992, 25 patients with non metastatic inoperable disease entered in the protocol. The stage of the disease was: T{sub 3}N{sub 0}4 patients, T{sub 3} with hydronephrosis seven patients, T{sub 3}N{sub 1} 12 patients, and T{sub 4}N{sub 0} two patients. Nineteen patients received two courses of CT with fluorouracil (F), cisplatin (P) with or without etoposide. Pelvic RT was given twice daily (two fractions of 3 Gy) on days 1, 3, 15 and 17. A combination of F 400 mg/m{sup 2}/d and P 15 mg/m{sup 2}/d in continuous infusion with oral etoposide (100 mg/d) and hydroxyurea (500 mg/d) in 11 patients was delivered concomitantly on days 1-3 and 14-17. A clinical and radiological evaluation was performed four weeks later. Patients with objective response underwent radical hysterectomy (group A) and those with incomplete response received additional RT-CT protocol (group B). All patients had endocavitary brachytherapy at the end of treatment. After two cycles of CT there were four PR in 19 patients and 5 failures. (authors). 36 refs., 1 fig.

Delanian, S.; Housset, M.; Maulard-Durdux, C. [Hopital Saint-Louis, 75 - Paris (France); Taurelle, R.; Lecuru, F. [Hopital boucicaut, 75 - Paris (France); Baillet, F. [Hopital Pitie-Salpetriere, 75 - Paris (France)

1995-12-31

202

Minimal deviation mucinous adenocarcinoma of the uterine cervix that proved difficult to differentiate from endometrial cancer: A case report  

OpenAIRE

Minimal deviation adenocarcinoma (MDA), also known as adenoma malignum of the uterine cervix, accounts for only ~1% of uterine cervical adenocarcinomas. Adenoma malignum of the uterine cervix was initially described by Gusserow in 1870. Using magnetic resonance imaging (MRI), MDA appears as multilocular lesions with solid components that extend from the endocervical glands to the deep cervical stroma. Cytological evaluation and biopsies have low detection rates, therefore, it is difficult to ...

Nishii, Yuko; Fukuda, Takeshi; Imai, Kenji; Yamauchi, Makoto; Hashiguchi, Yasunori; Ichimura, Tomoyuki; Yasui, Tomoyo; Sumi, Toshiyuki

2014-01-01

203

Intracavitary combined with CT-guided interstitial brachytherapy for locally advanced uterine cervical cancer. Introduction of the technique and a case presentation  

International Nuclear Information System (INIS)

We report a new technique of brachytherapy consisting of intracavitary combined with computed tomography (CT)-guided interstitial brachytherapy for locally advanced cervical cancer. A Fletcher-Suit applicator and trocar point needles were used for performing high-dose rate brachytherapy under in-room CT guidance. First, a tandem and ovoids were implanted into the patient's vagina and uterus by conventional brachytherapy method. Based on clinical examination and MRI/CT imaging, operating radiation oncologists decided the positions of insertion in the tumor and the depth of the needles from the upper surface of the ovoid. Insertion of the needle applicator was performed from the vaginal vault inside the ovoid within the tumor under CT guidance. In treatment planning, dwell positions and time adaptations within the tandem and ovoids were performed first for optimization based on the Manchester system, and then stepwise addition of dwell positions within the needle was continued. Finally, dwell positions and dwell weights were manually modified until dose-volume constraints were optimally matched. In our pilot case, the dose of D90 to high-risk clinical target volume was improved from 3.5 Gy to 6.1 Gy by using our hybrid method on the dose-volume histogram. D1cc of the rectum, bladder and sigmoid colon by our hybrid method was 4.8 Gy, 6.4 Gy and 3.5 Gy, respectively. This method consists of advanced image-guided brachytherapy that can be performed safely and accurately. T can be performed safely and accurately. This approach has the potential of increasing target coverage, treated volume, and total dose without increasing the dose to organs at risk. (author)

204

Intracavitary combined with CT-guided interstitial brachytherapy for locally advanced uterine cervical cancer: introduction of the technique and a case presentation.  

Science.gov (United States)

We report a new technique of brachytherapy consisting of intracavitary combined with computed tomography (CT)-guided interstitial brachytherapy for locally advanced cervical cancer. A Fletcher-Suit applicator and trocar point needles were used for performing high-dose rate brachytherapy under in-room CT guidance. First, a tandem and ovoids were implanted into the patient's vagina and uterus by conventional brachytherapy method. Based on clinical examination and MRI/CT imaging, operating radiation oncologists decided the positions of insertion in the tumor and the depth of the needles from the upper surface of the ovoid. Insertion of the needle applicator was performed from the vaginal vault inside the ovoid within the tumor under CT guidance. In treatment planning, dwell positions and time adaptations within the tandem and ovoids were performed first for optimization based on the Manchester system, and then stepwise addition of dwell positions within the needle was continued. Finally, dwell positions and dwell weights were manually modified until dose-volume constraints were optimally matched. In our pilot case, the dose of D90 to high-risk clinical target volume was improved from 3.5 Gy to 6.1 Gy by using our hybrid method on the dose-volume histogram. D1cc of the rectum, bladder and sigmoid colon by our hybrid method was 4.8 Gy, 6.4 Gy and 3.5 Gy, respectively. This method consists of advanced image-guided brachytherapy that can be performed safely and accurately. This approach has the potential of increasing target coverage, treated volume, and total dose without increasing the dose to organs at risk. PMID:21293072

Wakatsuki, Masaru; Ohno, Tatsuya; Yoshida, Daisaku; Noda, Shin-ei; Saitoh, Jun-ichi; Shibuya, Kei; Katoh, Hiroyuki; Suzuki, Yoshiyuki; Takahashi, Takeo; Nakano, Takashi

2011-01-01

205

Sterility of the uterine cavity.  

DEFF Research Database (Denmark)

In a prospective open study the sterility of the uterine cavity was evaluated in 99 women admitted for hysterectomy. The indications for hysterectomy were in most cases persistent irregular vaginal bleeding and fibromyomas of the uterus. Samples for both aerobic and anaerobic bacteria, Chlamydia trachomatis, yeasts and viruses were taken preoperatively from the apex of the vagina and cervical os. Immediately after hysterectomy the uterus was opened under sterile conditions and samples obtained from the isthmus and fundus of the uterine cavity for microbiological examination. Wet smears were taken from the same sites. Nearly a quarter of all the patients harbored one or more microorganisms in the uterus, mostly Gardnerella vaginalis, Enterobacter and Streptococcus agalactiae. We found that in a significant number of cases, the uterine cavity is colonized with potentially pathogenic organisms which may play a causative role in endometritis. The results indicate that inflammation of the uterine cavity should be evaluated by hysteroscopic examination before hysterectomy is undertaken in patients with persistent irregular vaginal bleeding. Udgivelsesdato: 1995-Mar

MØller, B R; Kristiansen, F V

1995-01-01

206

Imaging cervical cancer  

International Nuclear Information System (INIS)

Full text: Uterine cervical cancer is the third most common gynecological malignancy with a wide range of five year survival rate according to the tumor stage. Officially the treatment policy is chosen based on the clinical staging irrespective the substantial body of evidence that MRI is useful in evaluating malignant conditions of the female pelvis. The goal of the presentation is to highlight: 1) The results from screening tests; 2) The role of Imaging staging of cervical cancer; 3) The standard MRI protocol, recommended by the European Society of Uroradiology; 4) The new role of Imaging in guiding an individualized therapy and 5) The assessment of therapy effect. MRI, although not officially incorporated in the FIGO staging system, is already widely accepted as the most reliable imaging technique for the diagnosis, staging, treatment planning, and follow-up of cervical cancer. In summary, MRI plays a key role in staging, patient selection for treatment, and detection of disease recurrence.

207

Cervical and endometrial metastases of appendiceal goblet cell carcinoid.  

Science.gov (United States)

Appendiceal goblet cell carcinoid (GCC) is a rare tumor with histologic features of both adenocarcinoma and neuroendocrine tumor (carcinoid). Clinically, it behaves more aggressively than classic appendiceal carcinoid and commonly presents with peritoneal carcinomatosis. We report 2 cases of appendiceal GCC, one with uterine cervical involvement and the other with endometrial involvement as the initial presentations. The first patient's invasive cervical signet ring cell carcinoma was diagnosed on routine screening. The second patient presented with abnormal uterine bleeding, and endometrial curettage showed an adenocarcinoma with signet ring cell features. Primary appendiceal GCC was demonstrated in both cases after systematic clinical investigations. Metastatic appendiceal GCC to uterine cervix and endometrium can potentially be misinterpreted as primary cervical or endometrial signet ring cell carcinoma. Therefore, for any uterine cervical/endometrial signet ring cell carcinoma, a metastatic appendiceal GCC should be considered in the differential diagnosis, especially after excluding other primary sites. PMID:20441511

Pan, Zenggang; Repertinger, Susan; Leonard, Ronald; Bewtra, Chhanda; Gatalica, Zoran; Sharma, Poonam

2010-05-01

208

Nuclear DNA analysis of koilocytic and premalignant lesions of the uterine cervix.  

OpenAIRE

Cervical biopsy samples were taken from 79 patients who had various grades of cervical intraepithelial neoplasia or who showed evidence, in the form of koilocytosis, of human papillomavirus infection of the uterine cervix and from 10 women with normal cervices. The DNA content of the cells in the samples was analysed by flow cytometry. Analysis of the data obtained showed that the biopsy samples from women with cervical intraepithelial neoplasia and human papillomavirus lesions contained sign...

Hughes, R. G.; Neill, W. A.; Norval, M.

1987-01-01

209

Avaliação dos Métodos Empregados no Programa Nacional de Combate ao Câncer do Colo Uterino do Ministério da Saúde Evaluation of the Methods Employed by the National Program of Uterine Cervical Cancer Control of the Brazilian Health Ministry  

Directory of Open Access Journals (Sweden)

Full Text Available Objetivo: avaliar uma amostra populacional incluída no rastreamento proposto pelo Programa Nacional de Combate ao Câncer do Colo do Útero (PNCC, quanto aos seguintes aspectos: prevalência de resultados citológicos insatisfatórios; prevalência citológica de atipias escamosas e glandulares de significado indeterminado (ASCUS e AGUS e lesões intra-epiteliais de baixo grau (LBG e lesões intra-epiteliais de alto grau (LAG, comparando seus resultados com resultados anatomopatológicos de biópsias colposcopicamente dirigidas. Métodos: pela imprensa escrita, falada e televisionada, foram convocadas mulheres, com idade entre 35 e 49 anos, para realização de exames citopatológicos preventivos, a serem colhidos nas unidades da rede de saúde pública ou instituições credenciadas pelo SUS. As lâminas foram analisadas por laboratórios credenciados pelo PNCC, e as pacientes com alterações celulares da amostra populacional do Município de Naviraí/MS foram submetidas a exame colposcópico e biópsia dirigida. Resultados: a prevalência de alterações citológicas do tipo ASCUS, AGUS e lesões escamosas intra-epiteliais foi de 3,3%, índice próximo do previsto pelo PNCC (4%. O percentual de espécimes insatisfatórios para avaliação foi elevado (12,5%; das pacientes com resultados citológicos de ASCUS, AGUS ou LBG, 27,3% apresentavam neoplasia intra-epitelial de alto grau ao estudo anatomopatológico. Por outro lado, nas pacientes com citologia compatível com LAG a biópsia dirigida revelou, em 12,5% dos casos, neoplasia intra-epitelial de baixo grau. Conclusões: a escolha da citologia oncótica como método único de rastreamento no PNCC permitiu elevados índices de falso-negativos (27,3% e de falso-positivos (12,5%. No rastreamento de neoplasias cervicais, a colposcopia mostrou-se procedimento importante e indispensável para nortear as condutas terapêuticas a serem adotadas.Purpose: to evaluate a populational sample of the screening proposed by the National Program of Uterine Cervical Cancer Control (PNCC, regarding the following issues: frequency of unsatisfactory cytologic results, cytologic frequency of atypical squamous or glandular cells of undetermined significance (ASCUS, AGCUS, low- or high-grade squamous intraepithelial lesions (SIL, comparing the cytologic results with anatomicopathological results of colposcopically directed biopsies. Methods: through the written, broadcasting television and oral midia, women between 35 and 49 years were requested to have a preventive cytopathological test, to be collected by the authorized public health or other institutions accredited by SUS. The slides were analyzed by the program-authorized laboratories and all those patients from the populational sample from the municipality of Naviraí in the State of Mato Grosso do Sul with cellular alterations were submitted to colposcopy and directed biopsy. Results: the frequency of cytologic alterations of the ASCUS, AGCUS and SIL types was 3.3%, an index that is close to that predicted by the PNCC (4%; the percentage of samples that were unsatisfactory for evaluation was high (12.5%; among the ASCUS, AGCUS or low grade-SIL patients, 27.3% presented intraepithelial lesions of a high grade in the anatomicopathological study; while patients with cytology compatible with high grade-SIL, the directed biopsy revealed that 12.5% presented low-grade intraepithelial lesions. Conclusions: the choice of oncological cytology as the only method for the screening in the program allowed high indexes of false-negatives (27.3% and of false-positives (12.5%. In the screening of cervical neoplasms, colposcopy has shown to be an important and indispensable method to guide the therapeutical management to be adopted.

Alfredo Roberto Neto

2001-05-01

210

Avaliação dos Métodos Empregados no Programa Nacional de Combate ao Câncer do Colo Uterino do Ministério da Saúde / Evaluation of the Methods Employed by the National Program of Uterine Cervical Cancer Control of the Brazilian Health Ministry  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Objetivo: avaliar uma amostra populacional incluída no rastreamento proposto pelo Programa Nacional de Combate ao Câncer do Colo do Útero (PNCC), quanto aos seguintes aspectos: prevalência de resultados citológicos insatisfatórios; prevalência citológica de atipias escamosas e glandulares de signifi [...] cado indeterminado (ASCUS e AGUS) e lesões intra-epiteliais de baixo grau (LBG) e lesões intra-epiteliais de alto grau (LAG), comparando seus resultados com resultados anatomopatológicos de biópsias colposcopicamente dirigidas. Métodos: pela imprensa escrita, falada e televisionada, foram convocadas mulheres, com idade entre 35 e 49 anos, para realização de exames citopatológicos preventivos, a serem colhidos nas unidades da rede de saúde pública ou instituições credenciadas pelo SUS. As lâminas foram analisadas por laboratórios credenciados pelo PNCC, e as pacientes com alterações celulares da amostra populacional do Município de Naviraí/MS foram submetidas a exame colposcópico e biópsia dirigida. Resultados: a prevalência de alterações citológicas do tipo ASCUS, AGUS e lesões escamosas intra-epiteliais foi de 3,3%, índice próximo do previsto pelo PNCC (4%). O percentual de espécimes insatisfatórios para avaliação foi elevado (12,5%); das pacientes com resultados citológicos de ASCUS, AGUS ou LBG, 27,3% apresentavam neoplasia intra-epitelial de alto grau ao estudo anatomopatológico. Por outro lado, nas pacientes com citologia compatível com LAG a biópsia dirigida revelou, em 12,5% dos casos, neoplasia intra-epitelial de baixo grau. Conclusões: a escolha da citologia oncótica como método único de rastreamento no PNCC permitiu elevados índices de falso-negativos (27,3%) e de falso-positivos (12,5%). No rastreamento de neoplasias cervicais, a colposcopia mostrou-se procedimento importante e indispensável para nortear as condutas terapêuticas a serem adotadas. Abstract in english Purpose: to evaluate a populational sample of the screening proposed by the National Program of Uterine Cervical Cancer Control (PNCC), regarding the following issues: frequency of unsatisfactory cytologic results, cytologic frequency of atypical squamous or glandular cells of undetermined significa [...] nce (ASCUS, AGCUS), low- or high-grade squamous intraepithelial lesions (SIL), comparing the cytologic results with anatomicopathological results of colposcopically directed biopsies. Methods: through the written, broadcasting television and oral midia, women between 35 and 49 years were requested to have a preventive cytopathological test, to be collected by the authorized public health or other institutions accredited by SUS. The slides were analyzed by the program-authorized laboratories and all those patients from the populational sample from the municipality of Naviraí in the State of Mato Grosso do Sul with cellular alterations were submitted to colposcopy and directed biopsy. Results: the frequency of cytologic alterations of the ASCUS, AGCUS and SIL types was 3.3%, an index that is close to that predicted by the PNCC (4%); the percentage of samples that were unsatisfactory for evaluation was high (12.5%); among the ASCUS, AGCUS or low grade-SIL patients, 27.3% presented intraepithelial lesions of a high grade in the anatomicopathological study; while patients with cytology compatible with high grade-SIL, the directed biopsy revealed that 12.5% presented low-grade intraepithelial lesions. Conclusions: the choice of oncological cytology as the only method for the screening in the program allowed high indexes of false-negatives (27.3%) and of false-positives (12.5%). In the screening of cervical neoplasms, colposcopy has shown to be an important and indispensable method to guide the therapeutical management to be adopted.

Alfredo, Roberto Neto; Julisa Chamorro Lascasas, Ribalta; José, Focchi; Edmund Chada, Baracat.

2001-05-01

211

Runoff erosion  

OpenAIRE

Table of Contents PART I – THEORY OF RUNOFF EROSION CHAPTER 1 - RUNOFF EROSION – THE MECHANISMS CHAPTER 2 - LARGE SCALE APPROACHES OF RUNOFF EROSION CHAPTER 3 - MEASURING PRESENT RUNOFF EROSION CHAPTER 4 - MODELLING RUNOFF EROSION CHAPTER 5 - RUNOFF EROSION AND HUMAN SOCIETIES: THE INFLUENCE OF LAND USE AND MANAGEMENT PRACTICES ON SOIL EROSION PART II - CASE STUDIES CASE STUDIES – INTRODUCTION: RUNOFF EROSION IN MEDITERRANEAN AREA CASE STUDY 1: Soil Erosio...

Evelpidou, Niki; Cordier, Stephane; Merino, Agustin; Figueiredo, Toma?s; Centeri, Csaba

2013-01-01

212

Uterine Fibroids Fact Sheet  

Science.gov (United States)

... ePublications > Our ePublications > Uterine fibroids fact sheet ePublications Uterine fibroids fact sheet Print this fact sheet Uterine fibroids ... FDA warning on power morcellators in treatment for uterine fibroids If your doctor recommends a hysterectomy or myomectomy ...

213

Malignant Müllerian Mixed Tumor of the Uterine Cervix with a Small Cell Neuroendocrine Carcinoma Component  

OpenAIRE

Malignant Müllerian mixed tumors (MMMTs) of the uterine cervix are extremely rare, accounting for 0.005% of all cervical malignancies. To date, only approximately 50 well-documented cases have been reported. Although several epithelial components have been described in cervical MMMTs, small cell neuroendocrine carcinoma (SCC) has not appeared in the English literature. We present a 43-year-old woman, para 2 gravida 2, who had MMMT with SCC and rhabdomyosarcoma components in the uterine cervi...

Munakata, Satoru; Iwai, Emi; Tanaka, Tomohito; Nakamura, Michihiko; Kanda, Takayoshi

2013-01-01

214

HYSTEROSCOPY, A MINIMALLY INVASIVE METHOD FOR DIAGNOSIS AND TREATMENT OF UTERINE INFERTILITY  

OpenAIRE

Hysteroscopy is an endoscopic procedure which consists of introducing a telescope connected to a camera through the dilated cervical canal into the uterine cavity for the visualisation of the cervical canal, uterine cavity and tubal ostiums. It is a minimally invasive method that allows diagnosis and / or treatment of a wide variety of pathologies affecting the proper functionality of internal female genitalia (menstrual and reproductive function). Objectives: It seeks to examine both the fre...

Nora (Dumitriu) Miron; Ivona Anghelache-Lupa?cu; Demetra Socolov; Cristina David; Socolov, R.

2011-01-01

215

Blood flow MR imaging of the uterine arteries and of normal and malignant cervical tissue. Initial experiences with a 2D-STAR technique; Darstellung des Blutflusses in den Gebaermutterarterien und im normalen sowie malignen Gebaermuttergewebe mittels einer 2D-Multiphasen-Tagging-Technik  

Energy Technology Data Exchange (ETDEWEB)

Purpose. The aim of this pilot study was to evaluate a 2D-STAR technique as a non contrast-enhanced approach to demonstrate the uterine artery and its branches and to assess the cervical uterine blood flow in healthy volunteers and in patients with advanced uterine cervical carcinoma. Materials and methods. Seven healthy volunteers (mean age, 29 years) and twentytwo patients (mean age, 52 years) with advanced cancer of the uterine cervix (FIGO IIB-IVA) were prospectively examined by 2D-STAR imaging at different inversion delay times (300 ms-1900 ms) which showed the passage of a blood bolus through normal and malignant tissue of the uterine cervix. Results. The uterine artery was well visualized with short inversion delay times of 300 ms to 500 ms. It was characterized as single or multiple helical loops before dividing into its intracervical branches. The intracervical branching was observed at inversion delay times of 500 ms-700 ms. With longer inversion delay times arterial signal enhancement disappeared and cervical tissue enhancement was noted. Enhancement of benign tissue was observed at inversion delay times of 1100 ms-1700 ms, and in malignant tissue at shorter inversion delay times of 900 ms-1300 ms. The maximum of this diffuse signal enhancement of benign tissue was seen at inversion dealy times of 1500 ms (1100 ms-1700 ms), in malignant tissue at significantly (P<0.05) shorter inversion delay times of 1100 ms (900 ms to 1300). (orig.) [Deutsch] Ziel. In dieser Studie wurde untersucht, ob mittels einer 2D-Multiphasen-Tagging (2D-MPT)-Technik dynamische Informationen ueber den Blutfluss in den Gebaermutterarterien und normalem sowie malignem Gebaermuttergewebe gewonnen werden koennen. Material und Methoden. Sieben gesunde Probanden (Durchschnittsalter, 29 Jahre) und 22 Patienten (Durchschnittsalter, 52 Jahre) mit fortgeschrittenem Zervixkarzinom (FIGO IIB-IVA) wurden prospektiv mittels einer 2D-MPT-Sequenz untersucht. In einem Intervall von 300-1900 ms nach der Markierung eines arteriellen Bolus wurden neun 2D-MPT-Bilder akquiriert, die die Passage des Bolus durch die Gebaermutterarterien und normalem und malignem Gebaermuttergewebe zeigen. Ergebnisse. Die Gebaermutterarterien fuellten sich 300-500 ms nach der Blut-Bolusmarkierung und waren durch einen korkenzieherartigen Verlauf vor ihrem Eintritt in das Gebaermuttergewebe gekennzeichnet. Die intrauterinen Gefaessaufzweigungen stellten sich nach 500-700 ms dar. Nach 900-1300 ms bzw. 1100-1700 ms war die Perfusion von malignem und normalem Gewebe sichtbar, die grossen Gebaermutterarterien waren kaum bzw. nicht mehr zu sehen. Die maximale Signalintensitaet in malignem Gewebe war signifikant (p<0,05) hoeher und wurde signifikant (p<0,05) frueher erreicht als in benignem Gewebe. Schlussfolgerung. Mit Hilfe einer 2D-MPT-Sequenz gelingt ohne Verwendung von Kontrastmitteln eine komplette dynamische Darstellung der Gebaermutterarterien und der fruehen Gewebeperfusion von normalen und malignem Gebaermuttergewebe. Darueber hinaus wird malignes Gewebe frueher und staerker perfundiert als normales Gebaermuttergewebe. (orig.)

Hawighorst, H.; Bock, M.; Knopp, M.V.; Essig, M.; Schoenberg, S.O.; Schad, L.R.; Kaick, G. van [Deutsches Krebsforschungszentrum, Heidelberg (Germany). Forschungsschwerpunkt: Radiologische Diagnostik und Therapie; Knapstein, P.G. [Mainz Univ. (Germany). Frauenklinik

1998-06-01

216

Selective uterine arterial embolization of uterine myoma  

International Nuclear Information System (INIS)

Objective: Study the value of clinical application of Baiji and absorbable Gelatin in embolizing uterine myoma together with its effect, side effect and complication. Methods: 21 women with uterine myoma undergoing selective uterine arterial embolization by Seldinger's technique were studied. After retrograde trans-femoral introduction of a 5 french catheter, the uterine arteries were successively catheterized. Baiji and absorbable Gelatin sponge particles were injected through free flow until devasculariztion. Results: Uterine myomas blood supply came from bilateral uterine arteries demonstrated by angiography. All the supplying artery images disappeared after the embolization. 3-6 months follow-up study showed: a marked reduction in the size of myomata by 38%-90%. Clinical symptoms were improved. There was one failure cas and then underwent uterotomy due to infection. Conclusions: The short-term effect of using Baiji and absorbable Gelatin for embolizing uterine myoma is clinically significant, while long-term effects is still waiting for research

217

Uterine Fibroid Embolization  

OpenAIRE

Uterine fibroids are commonly asymptomatic. They often cause pelvic pain, abnormal and increased vaginal bleeding, etc. Traditional treatment of symptomatic uterine fibroids was trans-abdominal hysterectomy. Nowadays, uterine artery embolization (UAE), also called uterine fibroid embolization, is considered as a safe and highly-effective nonsurgical treatment for women with symptomatic uterine fibroid tumors. Advantages of UAE over conventional hormonal suppression and surgical procedures inc...

Malek, R.; Padidar, A.

2003-01-01

218

Polypoid uterine lesions mimicking endometrial stromal sarcoma.  

OpenAIRE

Two polypoid submucosal uterine lesions were examined histologically and immunohistochemically with monoclonal antibodies to desmin and alpha smooth muscle actin. One case comprised a leiomyoma and the other a polypoid form of adenomyosis. Both polyps had prolapsed through the external cervical os. The lesions had an ulcerated surface with focal areas of marked increased cellularity and pronounced vascularity throughout, such that they mimicked a low grade endometrial stromal sarcoma infiltra...

Mccluggage, W. G.; Alderdice, J. M.; Walsh, M. Y.

1999-01-01

219

Uterine metastasis of invasive ductal breast carcinoma diagnosed by cytological examination in an asymptomatic patient: an unusual case report  

Directory of Open Access Journals (Sweden)

Full Text Available Uterine metastasis of malignant tumors occurs very rarely. Despite abnormal uterine bleeding is the most common symptom of metastatic uterine disease, less than 5% of patients may have not any gynecologic symptoms and diagnosis is made usually following abnormal cervical cytology. Here we present a case of uterine metastasis of invasive ductal breast carcinoma that was diagnosed by cervical cytological examination during breast cancer follow up. Even if there are not any gynecologic symptoms and findings in a patient who has breast cancer history, a detail systematic pelvic examination of these patients must be done yearly.

Ça?da? Türky?lmaz

2007-10-01

220

Cervical Cancer  

Science.gov (United States)

... prevent cervical cancer or find it early: • The Pap test (or Pap smear) looks for precancers, cell changes, on the ... treated, so that cervical cancer is prevented. The Pap test also can find cervical cancer early, when ...

221

Cervical Dysplasia  

Science.gov (United States)

... a cervical loop electrosurgical excision procedure (LEEP) or cone biopsy (another type of excision using a scalpel or ... Cervical or endocervical biopsies and cervical LEEP and cone biopsy specimens are sent to a pathologist for microscopic ...

222

A possible association between cervical erosion in pregnant women and congenital abnormalities in their children?a population-based case-control study  

OpenAIRE

Objective to study the possible association between erosion of cervix in pregnant women (ECP) and structural birth defects, i.e. congenital abnormalities (CA) in their offspring. Study design: Comparison of cases with CA and all matched controls without any CA born to wo- men with prospectively and medical record ECP in the population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA). Results: HCC- SCA contained 22,843 cases and 38,151 matche...

Ferenc Bánhidy; Nándor Ács; Puho?, Erzse?bet H.; Czeizel, Andrew E.

2010-01-01

223

Estrogen and ER?: Culprits in Cervical Cancer?  

OpenAIRE

Estrogen and its receptors are implicated in the promotion and prevention of various cancers. While the uterine cervix is highly responsive to estrogen, the role of estrogen in cervical cancer, which is strongly associated with human papillomavirus (HPV) infections, is poorly understood. Recent studies in HPV transgenic mouse models provide evidence that estrogen and its nuclear receptor promote cervical cancer in combination with HPV oncogenes. While epidemiological studies further support t...

Chung, Sang-hyuk; Franceschi, Silvia; Lambert, Paul F.

2010-01-01

224

Uterine torsion in term pregnancy  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction Uterine torsion has been defined as a rotation of more than 45 degrees of the uterus around its long axis that occurs at the junction between the cervix and the corpus. The extent of the rotation is usually 180 degrees, although cases with torsion from 60 to 720 degrees have been reported. Aetiopathogenesis of this condition is still unclear. Establishing clinical diagnosis of this condition is difficult, but very important for reducing maternal and fetal morbidity and mortality. Clinical symptoms are either absent or nonspecific, and the diagnosis is usually made at laparotomy. Case outlineA 31-year old patient was admitted to the Institute of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, as an emergency, seven days upon the established intrauterine fetal demise in the 40th gestation week. On uterine examination, the cervical length of 1.5 cm and dilatation of 3 cm were determined, as well as a palpable soft tissue formation, not resembling placenta praevia. Ultrasound examination confirmed fetal demise and exclusion of the presence of placenta praevia. The labor was completed by caesarean section. During surgery, uterine torsion of 180 degrees to the right was diagnosed. There was a stillborn male baby, and the cause of death was intrauterine asphyxia. A fibrosing and calcified accessory lobe 9x6x2.5 cm in size was observed on placental examination, which is a possible sign of initial gemellary pregnancy. Conclusion The clinical presentation of uterine torsion is variable and clinical examination and ultrasonographic scanning may be insufficient for diagnosis. The method of choice for establishing the diagnosis is magnetic resonance imaging. Once the diagnosis of uterine torsion in pregnancy is established, emergency laparotomy is indicated. Following caesarean delivery, it is necessary to surgically remove all the anatomical causes of torsion, and rotate the uterus back to its normal position. There are some authors who suggest bilateral plication of the round ligaments as a preventive procedure for repeated torsion in puerperium and following pregnancies. The effectiveness of this method requires further investigation. It is necessary to have in mind the possibility of uterine torsion in all cases of abdominal pain during pregnancy and dystocia.

Spari? Radmila

2007-01-01

225

Cutaneous metastasis in cancer of the uterine cervix: A case report and review of the literature  

OpenAIRE

Carcinoma of the uterine cervix is a common neoplasm among Indian women; in fact, it is the commonest malignancy among rural Indian women. Uterine cervical cancer spreads mainly to the regional lymph nodes, with distant metastasis rarely occurring. Major sites of distant metastasis are lung, bone, and liver. Skin metastasis from carcinoma of the uterine cervix is a very rare event. The reported incidence ranges from 0.1 to 2%. Here we describe a 60-year-old woman with cervical cancer who deve...

Basu, Bishan; Mukherjee, Sucheta

2013-01-01

226

Late, isolated metastasis from poorly differentiated gastric cancer to the uterine cervix  

OpenAIRE

•Metastases from extrapelvic organs to the uterine cervix are rare.•Cervical metastases from the stomach are often accompanied by extrauterine metastases.•We report a case of cervical metastasis of gastric cancer, occurring 10 years after the first surgical treatment.

Yamamoto, Takuro; Mori, Taisuke; Matsushima, Hiroshi; Sawada, Morio; Kitawaki, Jo

2014-01-01

227

Uterine artery embolization - discharge  

Science.gov (United States)

Uterine fibroid embolization - discharge; UFE - discharge; UAE - discharge ... You had uterine artery embolization (UAE). UAE is a procedure to treat ... the blood supply of the fibroids was blocked. This caused ...

228

Uterine Fibroid Embolization  

Science.gov (United States)

Uterine Fibroid Embolization Baptist Health South Florida Miami, FL March 25, 2010 Good afternoon, and welcome to the ... today is going to be an embolization of uterine fibroids. So we're going to show you the ...

229

Uterine Fibroid Embolization  

Medline Plus

Full Text Available Uterine Fibroid Embolization Baptist Health South Florida Miami, FL March 25, 2010 Good afternoon, and welcome to the ... today is going to be an embolization of uterine fibroids. So we're going to show you the ...

230

Living with uterine fibroids  

Science.gov (United States)

Uterine fibroids are tumors that grow in a woman's womb (uterus). These growths are not cancerous. No one ... fibroids. You may have seen your doctor for uterine fibroids. They can cause: Heavy menstrual bleeding and long ...

231

High signals in the uterine cervix on T2-weighted MRI sequences  

International Nuclear Information System (INIS)

The aim of this pictorial review was to illustrate the normal cervix appearance on T2-weighted images, and give a review of common or less common disorders of the uterine cervix that appear as high signal intensity lesions on T2-weighted sequences. Numerous aetiologies dominated by cervical cancer are reviewed and discussed. This gamut is obviously incomplete; however, radiologists who perform MR women's imaging should perform T2-weighted sequences in the sagittal plane regardless of the indication for pelvic MR. Those sequences will diagnose some previously unknown cervical cancers as well as many other unknown cervical or uterine lesions. (orig.)

232

Vaginal misoprostol for cervical priming before hysteroscopy  

Directory of Open Access Journals (Sweden)

Full Text Available "nBackground: As an important diagnostic and therapeutic procedure for patients with intrauterine diseases, hysteroscopy permits a good view of the uterine cavity, thereby increasing diagnostic accuracy. Complications often encountered during hysteroscopy primarily concern problems with cervical dilatation and include uterine perforation, cervical tears, and the creation of false tracts. In this study, we investigate the utility of vaginal misoprostol for cervical dilatation in women undergoing hysteroscopy. "nMethods: This triple-blind, randomized, placebo-controlled study was carried out at Mirza Khoochak Khan Hospital, Tehran, Iran. We excluded women who were pregnant, had genital tract infection, or history of cervical trauma. We randomly assigned 80 women with abnormal uterine bleeding or intrauterine lesions to receive either 200 ?g vaginal misoprostol or placebo. Ten to twelve hours prior to hysteroscopy, the placebo or misoprostol was administered to the posterior vaginal fornix. Data regarding cervical response and outcome of operative hysteroscopy, as well as complications, were analyzed. "nResults: The mean cervical width, as estimated by Hegar dilator, was significantly greater in the treated group (7.8±1.6mm than that in the control group (5.6±2.2mm, p<0.001. In the misoprostol group, 28 (70% patients required cervical dilatation, compared with 38(95% in the placebo group (p=0.001. A significantly shorter median time of cervical dilatation to Hegar number 9 was found in the treated subjects than in the controls (60 vs. 180 seconds, p<0.001. The mean operative time was significantly shorter in the treated group (8.8±8.7 minutes compared with that of the control group (13.1±10.1 minutes, p=0.043. "nConclusions: Vaginal misoprostol before operative hysteroscopy lessens the need for cervical dilatation, facilitating hysteroscopic surgery.

Valadan M

2008-11-01

233

Applicator for use of cesium-137 miniaturized tube sources in the treatment of uterine cervix cancer  

International Nuclear Information System (INIS)

A modified afterloading Kumar Cervical Applicator with a 3 mm diameter central tandem permits insertion of the afterloading tandem into the uterus without need of manual cervical dilatation. While general anesthesia is required for insertion of standard cervical applicators, this is eliminated because the central tandem is no larger than a uterine sound, and the tandem may be painlessly inserted into the uterus while the patient is awake

234

Identifying Erosion  

Science.gov (United States)

In this environmental science activity (page 3 of the PDF), leaners will identify and explain the causes of erosion. They will observe the effects of erosion on the surrounding area and further explore examples of erosion online. An extension activity allows learners to make a hands-on model of soil erosion. Though this was created as a pre-visit activity for a workshop about water flow and erosion, it makes a great stand-alone activity as well!

COSI

2009-01-01

235

Uterine endometrial stromal sarcoma located in uterine myometrium: MRI appearance  

International Nuclear Information System (INIS)

Two cases of uterine endometrial stromal sarcoma whose main mass was located in uterine myometrium are reported. They mimicked uterine leiomyoma with cystic degeneration or uterine leiomyosarcoma. Endometrial stromal sarcoma should be suggested in the differential diagnosis of mass lesion in uterine myometrium. (orig.)

236

Uterine endometrial stromal sarcoma located in uterine myometrium: MRI appearance  

Energy Technology Data Exchange (ETDEWEB)

Two cases of uterine endometrial stromal sarcoma whose main mass was located in uterine myometrium are reported. They mimicked uterine leiomyoma with cystic degeneration or uterine leiomyosarcoma. Endometrial stromal sarcoma should be suggested in the differential diagnosis of mass lesion in uterine myometrium. (orig.)

Ueda, M.; Otsuka, M.; Hatakenaka, M. [Dept. of Radiology, Medical Institute of Bioregulation, Kyushu University, Beppu (Japan); Torii, Y. [Dept. of Radiology, Saga Prefectural Hospital (Japan)

2000-05-01

237

Anatomical differences in uterine sensitivity to prostaglandin F(2alpha) and serotonin in non-pregnant rats.  

Science.gov (United States)

The ovarian steroids regulate the sensitivity of a population of uterine receptors to prostaglandin F(2alpha), serotonin and oxytocin. However, the uterine sensitivity to prostaglandin F(2alpha) and oxytocin does not coincide with the estrogen-induced increase in the number of receptors. Anatomical differences affect the uterine sensitivity to agonists. We investigated whether anatomical differences between ovarian and cervical uterine regions modulate the hormone-regulated sensitivity to prostaglandin F(2alpha), serotonin and oxytocin. Non-cumulative concentration-response curves for these agonists were recorded for ovarian and cervical uterine segments from adult ovariectomized rats treated with 17beta-estradiol, 17beta-estradiol+progesterone, or vehicle. The ovarian segments displayed a higher maximal response (E(max)) to prostaglandin F(2alpha) and a lower E(max) to serotonin than the cervical segments. Both uterine segments displayed a similar sensitivity to oxytocin. The ovariectomized controls displayed the highest E(max) and the lowest effective concentration 50 (EC(50)) for oxytocin and prostaglandin F(2alpha). Anatomical differences between ovarian and cervical uterine regions modulate the hormonal regulation of uterine sensitivity to serotonin and prostaglandin F(2alpha) in the non-pregnant rat uterus. PMID:12098598

Oropeza, Martha V; Ponce-Monter, Hector; Villanueva-Tello, Teodoro; Palma-Aguirre, José Antonio; Campos, Maria G

2002-06-20

238

A possible association between cervical erosion in pregnant women and congenital abnormalities in their children?a population-based case-control study  

Directory of Open Access Journals (Sweden)

Full Text Available Objective to study the possible association between erosion of cervix in pregnant women (ECP and structural birth defects, i.e. congenital abnormalities (CA in their offspring. Study design: Comparison of cases with CA and all matched controls without any CA born to wo- men with prospectively and medical record ECP in the population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA. Results: HCC- SCA contained 22,843 cases and 38,151 matched controls, the informative offspring of 40 (0.18% case mothers and the newborns of 25 control mothers (0.07% with ECP were compared and the higher risk for total CA (adjusted OR with 95% CI: 2.7, 1.6-4.4 was found explained by the higher risk of 9 cases with hypospadias (OR with 95% CI: 4.5, 2.1-9.7 and 10 cases with car-diovascular CAs (OR with 95% CI: 3.4, 1.6-7.1, particularly with conotruncal CAs. Conclusions: An unexpected possible association of ECP with higher risk for hypospadias and conotrun-cal cardiovascular CAs was found and these findings are considered as signals that need confirmation or rejection

Ferenc Bánhidy

2010-08-01

239

MRI diagnosis and staging of cervical carcinoma  

International Nuclear Information System (INIS)

Objective: To study the MRI features of uterine cervical carcinoma and to evaluate the value of MR imaging in preoperative staging of uterine cervical carcinoma. Methods: Pelvic MR imaging was performed in 98 patients with cervical carcinoma proved by pathology including 45 patients with operation. MRI was performed within 3 days ?15 days (average 7.5 days) before operation. The MRI scanning included axial SE T1WI, axial and sagittal TSE T2WI, coronal SPIR TSE T2WI, and axial, sagittal, and coronal Gd-DTPA enhanced SE T1WI. MR images were analyzed for location, signal characteristic, and extension of the primary tumor. MR findings were compared with surgical-pathologic findings. Results: MRI findings of cervical carcinoma were very characteristic which appeared as moderate hyperintensity on T2WI, and there was a significant contrast noise ratios among the cervical carcinoma, normal cervix, and the parametric tissue. The tumor showed hypointense on T1WI, and mild enhancement after bolus intravenous Gd-DTPA. In 33 patients, the signal of the tumor was heterogeneous, which was caused by pseudoglandular lumen, necrosis, and keratin pearl. The accuracy of MR imaging in determination of tumor location was 100%. The accuracy, specificity, and sensitivity for parametric extension were 88.9%, 90.6% and 84.6%, respectively. Overall, the accuracy of MR imaging in staging was 88.9%. Conclusion: MRI imaging can shas 88.9%. Conclusion: MRI imaging can show the local tumors and extension of the cervical carcinoma clearly on multi planes and angles. MR imaging is superior to clinical evaluation in the staging of uterine cervical carcinoma, and should be regarded as a routine preoperative imaging study for cervical carcinoma

240

Malignant mixed mullerian tumor arising from the uterine cervix: A case report  

International Nuclear Information System (INIS)

Malignant mixed mullerian tumors (MMMTs) are a rare uterine tumor and contribute to approximately 1-3% of all corpus malignant tumors. MMMTs are usually in the uterine corpus, but can also arise from the uterine cervix, vagina, ovaries and fallofian tubes. MMMTs of the uterine cervix are extremely rare. MMMTs are highly malignant and tend to maintain a rapid growth and exhibit a high rate of recurrence. Therefore, the prognosis of patients diagnosed with these types of tumors is extremely poor. We report a rare case of a malignant mixed mullerian tumor arising from the uterine cervix and introduce CT and MRI findings. CT and magnetic resonance findings of the uterine cervical MMMT in our case show highly aggressive features, such as parametrial involvement, pelvic and paraaortic lymphadenopathy, and distant metastasis and high enhancement

241

Cervical Cancer  

Science.gov (United States)

... the place where a baby grows during pregnancy. Cervical cancer is caused by a virus called HPV. The ... for a long time, or have HIV infection. Cervical cancer may not cause any symptoms at first. Later, ...

242

Cervical Cancer  

Centers for Disease Control (CDC) Podcasts

Did you know that cervical cancer rates differ by race/ethnicity and region? Or that cervical cancer can usually be prevented if precancerous cervical lesions are found by a Pap test and treated? Find out how getting regular Pap tests can save a woman's life.  Created: 3/6/2007 by National Breast and Cervical Cancer Early Detection Program.   Date Released: 4/25/2007.

2007-03-06

243

Uterine artery embolization to treat uterine fibroids  

International Nuclear Information System (INIS)

The first reported application of uterine artery embolization, in 1979, was to treat life-threatening hemorrhage after a failed hysterectomy. Since then, uterine artery embolization has been used very successfully to control acute or delayed post-partum hemorrhage, post-surgical hemorrhage and hemorrhage from ectopic pregnancy, to treat uterine arteriovenous malformations and as prophylaxis before high-risk surgery, such as cesarean delivery in women with placenta previa. In contrast to these proven but underutilized applications, uterine embolization for fibroids has, in a short time, achieved significant notice in the lay press and is being widely offered. Ravina and colleagues, first reported uterine fibroid shrinkage after embolization for the treatment of acute bleeding. Since then, his group has performed over 100 procedures with up to a 6-year follow-up. The cumulative clinical success rate for the treatment of abnormal uterine bleeding due to fibroids is reported to be approximately 85% and for treatment of pain or pressure symptoms, about 75%. Six-month follow-up sonography reveals an average reduction of fibroid size of approximately 40%. However, to date, no studies have compared patients who undergo embolization with a nontreatment cohort or with surgical intervention. (author)

244

Uterine artery embolization to treat uterine fibroids  

Energy Technology Data Exchange (ETDEWEB)

The first reported application of uterine artery embolization, in 1979, was to treat life-threatening hemorrhage after a failed hysterectomy. Since then, uterine artery embolization has been used very successfully to control acute or delayed post-partum hemorrhage, post-surgical hemorrhage and hemorrhage from ectopic pregnancy, to treat uterine arteriovenous malformations and as prophylaxis before high-risk surgery, such as cesarean delivery in women with placenta previa. In contrast to these proven but underutilized applications, uterine embolization for fibroids has, in a short time, achieved significant notice in the lay press and is being widely offered. Ravina and colleagues, first reported uterine fibroid shrinkage after embolization for the treatment of acute bleeding. Since then, his group has performed over 100 procedures with up to a 6-year follow-up. The cumulative clinical success rate for the treatment of abnormal uterine bleeding due to fibroids is reported to be approximately 85% and for treatment of pain or pressure symptoms, about 75%. Six-month follow-up sonography reveals an average reduction of fibroid size of approximately 40%. However, to date, no studies have compared patients who undergo embolization with a nontreatment cohort or with surgical intervention. (author)

Machan, L.; Martin, M. [Univ. of British Columbia Hospital, Dept. of Radiology, Vancouver, BC (Canada)

2001-06-01

245

Postmenopausal uterine bleeding.  

Science.gov (United States)

The purpose of this study was to evaluate the incidence of the etiologic factors of postmenopausal uterine bleeding and the recurrence rate of uterine bleeding before total hysterectomy. Six hundred and twenty-eight patients (mean age 52.2) with postmenopausal uterine bleeding were studied. Atrophic endometrium was found in 522 cases (83.1%), carcinoma of the endometrium in 70 cases (11.1%), proliferative endometrium in 29 cases (4.6%) and secretory endometrium in 7 cases (1.1%). The recurrence rate of uterine bleeding was very high in carcinoma of the endometrium, moderate in proliferative endometrium and low in secretory and atrophic endometrium. PMID:9478305

Iatrakis, G; Diakakis, I; Kourounis, G; Sakellaropoulos, G; Rammos, G; Ladopoulos, J; Calpaktsoglou, C; Efthymiou, G; Prapa, Z; Tsionis, C; Tzingounis, V

1997-01-01

246

Total and acute uterine inversion after delivery: a case report  

Science.gov (United States)

Introduction Uterine inversion is a rare obstetric emergency that can lead to hypovolemic shock or even maternal death. There are many management strategies, but they are poorly described and dispersed in the medical literature. The purpose of this article is to describe a case of complete acute uterine inversion and a review of the literature. Case presentation The authors describe a case of complete uterine inversion after a normal delivery with fundal placenta and without cord traction, in a 33-year-old Caucasian woman. After the diagnosis was made and after several attempts of manual correction of the inversion, the patient was taken immediately to the operating room and a laparotomy was performed. With opposing pressures in the cervical ring through the abdominal cavity and on the uterus fundus through her vagina, the inversion was resolved. An incision on the cervical ring was unnecessary. Due to incomplete detachment of the placenta the bleeding was mild. She recovered without complications and the histological examination of placenta was unremarkable. In this case, the only risk factor for uterine inversion was the fundal implantation of the placenta. Conclusions The low incidence of uterine inversion leads to sparse experience in resolving this obstetrical emergency. The best prognosis occurs in situations where the diagnosis and maneuvers for uterine reversal are made at an early stage. The authors concluded that opposing pressures in the cervical ring through the abdominal cavity and on the uterus fundus through the vagina can resolve the inversion without the need of other surgical techniques. It is essential to keep in mind this diagnosis, and be updated about the strategies required to solve this complication. PMID:25326075

2014-01-01

247

ANALISIS CRITICO DEL MANEJO DE LA INCOMPETENCIA CERVICAL  

Directory of Open Access Journals (Sweden)

Full Text Available La incompetencia cervical se caracteriza por la dilatación progresiva del cuello uterino en ausencia de contracciones uterinas. Esta condición es causa de aborto de segundo trimestre y parto prematuro. Clásicamente el tratamiento ha sido el cerclaje cervical, cuya utilidad, sin embargo, no ha sido demostrada. La evidencia disponible, y el uso clínico habitual sugiere que el grupo de pacientes con historia clínica característica de incompetencia cervical (abortos repetidos de segundo trimestre secundarios a dilatación cervical pasiva, se beneficiarían del cerclaje cervical en forma electiva entre las 12-14 semanas. Sin embargo, la evidencia no es concluyente respecto de cuál es la mejor opción terapéutica para las pacientes sin historia característica, pero en riesgo de incompetencia cervical (acortamiento cervical ecográfico o antecedente de parto prematuro. Se requiere de estudios randomizados de buen diseño para resolver la pregunta en cada grupoCervical Incompetence is characterized by progressive cervical dilation in the absence of uterine contractions, leading to second trimester abortion and preterm birth. Cerclage has been used for Cervical Incompetence however its efficacy has not been confirmed. The best evidence and clinical judge suggest that those patients with classical history of cervical incompetence (recurrent painless dilation and spontaneous midtrimester abortion will benefit of elective cerclage at 12-14 weeks. However, the evidence is not conclusive for patients with no history, but at risk of cervical incompetence (cervical shortening evidenced by ultrasound or antecedents of preterm birth. Randomized trials are needed to answer this question for each group

Víctor Miranda H

2003-01-01

248

Erosion Basics  

Science.gov (United States)

This homepage of Dr. Richard A. McLaughlin at North Carolina State University includes a four-part tutorial about soil erosion and mitigation. Slide presentations include an introduction to the factors that lead to soil erosion, a general discussion of soil characteristics and susceptibility to erosion, an overview of the formation of rills and gullies, and some examples of sediment transport dynamics and erosion reduction techniques. The site also features short videos that show tests of erosion control methods in an artificial environment.

Richard A. McLaughlin

249

Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia  

Directory of Open Access Journals (Sweden)

Full Text Available Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron entrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %, 36 citología anormal (2 % y 638 cambios celulares reactivos asociados a inflamación (37 %. Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país.Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire to collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %, 36 abnormal cytology (2 % and 638 reactive cellular changes associated with inflammation (37 %. The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

Yaliana Tafurt-Cardona

2012-02-01

250

Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia / The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron e [...] ntrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %), 36 citología anormal (2 %) y 638 cambios celulares reactivos asociados a inflamación (37 %). Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país. Abstract in english Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire t [...] o collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %), 36 abnormal cytology (2 %) and 638 reactive cellular changes associated with inflammation (37 %). The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

Yaliana, Tafurt-Cardona; Claudia P, Acosta-Astaiza; Carlos H, Sierra-Torres.

2012-02-01

251

Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia / The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: Spanish Abstract in spanish Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron e [...] ntrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %), 36 citología anormal (2 %) y 638 cambios celulares reactivos asociados a inflamación (37 %). Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país. Abstract in english Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire t [...] o collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %), 36 abnormal cytology (2 %) and 638 reactive cellular changes associated with inflammation (37 %). The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

Yaliana, Tafurt-Cardona; Claudia P., Acosta-Astaiza; Carlos H., Sierra-Torres.

2012-02-01

252

Intra-uterine insemination with prepared sperm vs. unprepared first split ejaculates. A randomized study.  

Science.gov (United States)

In this randomized prospective study, we determined the conception rate following intra-uterine insemination with washed and prepared sperm, or with the first portion of a split ejaculate, in couples with longstanding male (n = 27, 70 treatment cycles) or cervical infertility (n = 14, 29 treatment cycles). Folliculogenesis and ovulation were induced by human menopausal gonadotropin and human chorionic gonadotropin. Significantly more couples conceived in the male infertility group following intra-uterine insemination with washed sperm, than after intra-uterine insemination with split ejaculate (9 vs. 2; P less than 0.05), while no difference in pregnancy rate (2 vs. 2) was found by the two intra-uterine insemination methods in the cervical infertility group. PMID:1503250

Goldenberg, M; Rabinovici, J; Bider, D; Lunenfeld, B; Blankstein, J; Weissenberg, R

1992-01-01

253

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... what we see here is a very abnormal uterine artery, the very rich blood supply. And that is typical of a woman ... is to make sure that there's still some blood flow in that main uterine artery, but the little branches no longer have flow. ...

254

Radiotherapy in the treatment of a locally advanced cervical cancer: experience of the Casablanca Radiotherapy-Oncology centre; Radiotherapie dans le traitement du cancer du col uterin localement evolue: experience du centre de radiotherapie-oncologie de Casablanca  

Energy Technology Data Exchange (ETDEWEB)

The authors report the assessment of the local control and relapse rates in a set of 70 patients who had been treated in 2004 and 2005 by radiotherapy associated or not with chemotherapy for a cervical cancer of stage IIbd, III or IVa according to the FIGO classification. The obtained results correspond to that published in literature. The authors expect that the improvement of radiotherapy techniques could improve these results. Short communication

Bouchbika, Z.; Benchakroun, N.; Sellal, N.; Jouhadi, H.; Tawfiq, N.; Sahraoui, S.; Benider, A. [Service radiotherapie-oncologie, CHU Ibn-Rochd, Casablanca (Morocco)

2011-10-15

255

Results of a retrospective study of chemo-radiotherapy for locally advanced cervical cancers; Resultats d'une etude retrospective de chimioradiotherapie dans les cancers du col uterin localement evolues  

Energy Technology Data Exchange (ETDEWEB)

The authors report a retrospective study performed on a set of 285 patients treated for locally advanced cervical cancers between 2003 and 2005. They aimed at analyzing the epidemiological, therapeutic and evolution profiles of this category of patients where cancer is discovered as it has already advanced. It appears that chemo-radiotherapy results in a longer survival, an increased local control, and a reduced metastatic dissemination, without increasing late toxicity. Short communication

Ayad, M.; Mesli, S.; Rabahi, K.; Boualga, K. [Centre anticancer, Blida (Algeria)

2011-10-15

256

Importancia de los estudios de inmunohistoquímica en el diagnóstico y la evaluación pronóstica de la neoplasia intraepitelial y el cáncer cervical: Revisión / Importance of immunohistochemical studies in the diagnosis and the prognostic evaluation of cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix: Review  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Se evaluó la expresión de proteínas dependientes de genes en el epitelio cervical, en la neoplasia intraepitelial cervical (NIC) y en el carcinoma del cuello uterino (CC) a través de diversos estudios de inmunohistoquímica (IHQ). Se examinó la detección de ciertas proteínas como p53, bcl2, C-Myc, Ki [...] 67, Ciclinas, P16 INK4a, p21, p27, b-catenina, Wnt y MCM, en relación con la evolución de la neoplasia intraepitelial, el carcinoma cervical y la infección con el virus del papiloma humano (VPH). Se señaló como la actividad transcripcional de diversos genes provoca alteraciones de la heterocigosis y pérdida de regiones cromosómicas que influyen en la sobrexpresión de proteínas o en la pérdida parcial de la expresión de algunas glicoproteínas en la superficie celular por la activación de genes del VPH. Abstract in english Immunohistochemical studies in cervical intraepithelial neoplasia and cervical carcinoma are evaluated in this review. A variety of proteíns like p53, bcl2, C-Myc, Ki 67, Cyclines, P16 INK4a, p21, p27, b-catenin, Wnt and MCM, have been related to the development of cervical neoplasia and human papil [...] loma virus infection. It is described how transcriptional factors of genes induce loss of heterozygosity, numerical chromosome abnormality and inactivation of gene products or the partial loss of some membrane glycoproteins induced by oncogenic human papillomaviruses (HPV).

Jorge, García-Tamayo; Julia, Molina; Eduardo, Blasco-Olaetxea.

2009-06-01

257

Uterine activity plotted on an inductograph as an aid to management of labour.  

Science.gov (United States)

By combining uterine activity data with an "inductograph" it is possible to distinguish between normal progress and at least three different types of delayed progress during the early stage of stimulated labour. Delayed progress may be associated with optimal, insufficient or, sometimes, excessive uterine activity. The patterns described facilitate early recognition and management of clinical problems such as cephalopelvic disproportion, undue cervical resistance, inadequate myometrial activity, and impending fetal distress. PMID:7362798

Gee, H; Beazley, J M

1980-02-01

258

Effect of the estrous cycle on uterine infection induced by Escherichia coli.  

OpenAIRE

Escherichia coli was inoculated into the uterine lumen of rats and rabbits at different estrous stages; one uterine horn of each animal was ligated at the cervical end. In rats, a large number of E. coli were retained in the ligated horns regardless of the estrous stage. E. coli inoculated at diestrus or pseudopregnancy induced purulent endometritis, but when inoculated at proestrus-estrus the organism caused asymptomatic infection. In nonligated horns, few E. coli were recovered, and marked ...

Nishikawa, Y.; Baba, T.; Imori, T.

1984-01-01

259

[A case of 11 operation because of genitourilal abnormalites and cervical carcinoma].  

Science.gov (United States)

A case of young woman with 11 operation because of genitourinal abnormalities and cancer of the uterine cervix. The patient was with bladder exstrophy and 2nd stage cervical cancer, treated operatively and with chemotherapy. Because local recurrence she was operated 3 times. The patient died 3 years after initial treatment of the cervical cancer. PMID:20225500

Chakalova, G; Angelova, E; Kostova, P

2009-01-01

260

Primary non-Hodgkin's lymphoma of the uterine cervix: A case report  

Directory of Open Access Journals (Sweden)

Full Text Available Primary uterine cervical non-Hodgkin's lymphomas (NHL are rare. Limited experience dictates careful pretherapy evaluation and multidisciplinary approach in treatment planning. A 53-year-old woman presented with postmenopausal bleeding and PAP smear IIIb. Cervical biopsy and endocervical curettage biopsy revealed NHL of the uterine cervix. Abdominal hysterectomy with bilateral adnexectomy was followed by pelvic lymphadenectomy due to lymph node metastasis, 21 months after the primary operation. Subsequently, the patient received postoperative chemotherapy. Seven years after the onset of NHL she is alive with no evidence of disease recurrence.

Živaljevi? Milica

2004-01-01

261

Preprocessing for Automating Early Detection of Cervical Cancer  

OpenAIRE

Uterine Cervical Cancer is one of the most common forms of cancer in women worldwide. Most cases of cervical cancer can be prevented through screening programs aimed at detecting precancerous lesions. During Digital Colposcopy, colposcopic images or cervigrams are acquired in raw form. They contain specular reflections which appear as bright spots heavily saturated with white light and occur due to the presence of moisture on the uneven cervix surface and. The cervix region ...

Das, Abhishek; Kar, Avijit; Bhattacharyya, Debasis

2011-01-01

262

Uterine Fibroid Embolization  

Directory of Open Access Journals (Sweden)

Full Text Available Uterine fibroids are commonly asymptomatic. They often cause pelvic pain, abnormal and increased vaginal bleeding, etc. Traditional treatment of symptomatic uterine fibroids was trans-abdominal hysterectomy. Nowadays, uterine artery embolization (UAE, also called uterine fibroid embolization, is considered as a safe and highly-effective nonsurgical treatment for women with symptomatic uterine fibroid tumors. Advantages of UAE over conventional hormonal suppression and surgical procedures include avoidance of the side effects of drug therapy and surgery-related physical and psychological trauma. These patients commonly resume their normal activities within a week after the procedure; weeks earlier than that for trans-abdominal hysterectomy. Over the past 30 years, interventional radiologists have done UAE for treatment of emergency uterine bleeding. Since 1995, interventional radiologists have turned their attention to treatment of uterine fibroids with a similar procedure. The first fibroid embolization in Iran was done approximately three years ago. So far, more than 100 cases have been treated by this method and it is going to be quickly accepted as a safe alternate for surgery.

"R. Malek

2003-06-01

263

Normal uterine activity on a sup(99m)Tc-glucoheptonate renal scan  

International Nuclear Information System (INIS)

Uterine radioactivity uptake has previously been reported for a variety of radionuclide agents in the presence of uterine pathological disorders, such as leiomyomata as well as uterine and cervical neoplasma and infections. Activity within the normal uterus has also been reported in Meckel's scans using sup(99m)Tc-pertechnetate, but this has not been reported for other radionuclide agents. We report a case exhibiting radioactivity uptake within a normal uterus on a sup(99m)Tc-glucoheptonate scan of a renal transplant. Awareness of the possibility of radioactivity uptake in a normal uterus is important in order to avoid potential confusion with abnormal pelvic masses or fluid occumulations. (orig.)

264

CRYOTHERAPY IN CERVICAL INTRAEPITHELIAL NEOPLASIA  

OpenAIRE

Cryotherapy is a time proven ablative method of treating lower grades of cervical dysplasia. It  is done using compressed CO2 or N2O refrigerant with the aim of creating an ice ball with a depth of freeze denoted by a peripheral margin of 4-5 mm of frost. It is performed using a double freeze or single freeze technique. Currently the double freeze technique of cryotherapy is an accepted treatment for mild and focal moderate dysplasia of the uterine cervix. The success of cryotherapy is deter...

Naina Kumar

2013-01-01

265

Uterine Leiomyoma: Hysterosalpingographic Appearances  

Directory of Open Access Journals (Sweden)

Full Text Available Uterine leiomyoma is the most common benign tumor of genital tract. The etiology of myomasis unknown. Leiomyoma shows a broad spectrum of radiographic appearances depending on thenumber, size, and location of the tumor. The diagnostic method for uterine leiomyomas is basedprimarily on the clinical situation. Despite of the varied diagnostic options such as; transvaginalsonography, sonohysterography, hysteroscopy, laparoscopy and MRI; hysterosalpingography isstill one of the valuable imaging methods for identification of uterine leiomyoma.The various features of the proved leiomyoma are illustrated in this pictorial review. The incidence,risk factors and clinical features will also be discussed briefly.

Firoozeh Ahmadi

2008-01-01

266

DETECTION OF CANCEROUS LESION BY UTERINE CERVIX IMAGE SEGMENTATION  

OpenAIRE

This paper works at segmentation of lesion observed in cervical cancer, which is the second most common cancer among women worldwide. The purpose of segmentation is to determine the location for a biopsy to be taken for diagnosis. Cervix cancer is a disease in which cancer cells are found in the tissues of the cervix. The acetowhite region is a major indicator of abnormality in the cervix image. This project addresses the problem of segmenting uterine cervix image into different regions. We a...

Priya, P.

2014-01-01

267

Factors affecting uterine electrical activity during the active phase of labor prior to rupture of membranes.  

Science.gov (United States)

Abstract Objective: Limited data exist regarding uterine contraction intensity prior to membrane rupture. Using a novel technique of electrical uterine myography (EUM) we aimed to determine which factors affect myometrial activity during active phase of labor. Methods: EUM was prospectively measured in 37 women with singleton pregnancy at term during the active phase of labor until membranes' rupture. EUM was measured using non-invasive nine channels recorder with an EMG amplifier and three-dimensional position sensor. Uterine electrical activity was quantified with the EUM-index, defined as the mean electrical activity of the uterine muscle over a period of 10?min and measured in units of micro-Joule (microwatt per second [mW/s]). Results: The mean EUM-index at the first 10?min of the measurement was 3.3?±?0.6?mW/s. In a stepwise linear regression model accounting potential confounders EUM was significantly affected by cervical dilatation (p?=?0.005), maternal age (p?=?0.04) and previous cesarean delivery status (p?=?0.02). In a repeated measurement assessment of non-parametric Fridman's test for all subjects who had at least 10 continuouss EUM measurements, there was a significant increase in electrical uterine activity as labor progressed (p?=?0.01). Conclusion: Electrical uterine activity during the active phase of labor prior to rupture of membranes is affected by maternal age, previous cesarean delivery status and cervical dilatation. Moreover, electrical uterine activity is enhanced throughout labor. PMID:25212973

Hiersch, Liran; Salzer, Liat; Aviram, Amir; Ben-Haroush, Avi; Ashwal, Eran; Yogev, Yariv

2014-09-29

268

Plicae palmatae of the cervical canals in uterus didelphys: MR imaging.  

Science.gov (United States)

The plicae palmatae are normal endocervical folds on the anterior and posterior walls. The median longitudinal ridges of the plicae palmatae have been considered to represent a remnant of fused Müllerian ducts. We present a case of uterus didelphys in which the longitudinal ridge of the plicae palmatae were obviously demonstrated on both of the uterine cervices on axial T2-weighted image. The observation of the plicae palmatae on the duplicated uterine cervices indicates the plicae palmatae is an inherent structure of the cervical canal, not a remnant of fused Müllerian duct. PMID:22160342

Takahata, Akiko; Koyama, Takashi

2012-10-01

269

Cervical Polyps  

Science.gov (United States)

... all polyps should be removed and examined for signs of cancer. The cause of cervical polyps is not well understood, but they are ... be able to feel it or see it. Cervical polyps are discovered during routine pelvic ... cancer, which is rare. Prevention Visit your doctor for ...

270

Cervical Cancer  

Science.gov (United States)

... Department of Health and Human Services, Office on Women’s Health http://www.womenshealth.gov 1-800-994-9662 TDD: 1-888-220-5446 Cervical Cancer Q: What is cervical cancer? A: Cancer is a disease that happens when body cells don't work right. The cells divide really fast and grow out ...

271

Cervical neuroblastoma.  

Science.gov (United States)

Cervical neuroblastoma is relatively uncommon. It present, most often as a firm mass in the lateral neck. Primary neuroblastomas of the neck usually arise in the cervical sympathetic ganglia. They are the sixth most common head and neck extracranial neoplasms. Neuroblastoma is the most common malignancy in children under 1 year of age. No known cause of Neuroblastoma has been reported. PMID:23120455

Singh, Harjitpal; Mohan, C; Mohindroo, N K; Sharma, D R

2007-09-01

272

Cervical neuroblastoma  

OpenAIRE

Cervical neuroblastoma is relatively uncommon. It present, most often as a firm mass in the lateral neck. Primary neuroblastomas of the neck usually arise in the cervical sympathetic ganglia. They are the sixth most common head and neck extracranial neoplasms. Neuroblastoma is the most common malignancy in children under 1 year of age. No known cause of Neuroblastoma has been reported.

Singh, Harjitpal; Mohan, C.; Mohindroo, N. K.; Sharma, D. R.

2007-01-01

273

Cervical Adenocarcinoma  

Science.gov (United States)

... in the endocervix. The most common subtype of cervical cancer, called squamous cell carcinoma, arises from the surface lining of the ectocervix, usually at the area where the ectocervix connects to the endocervix. If not successfully treated at an early stage, cervical cancer is capable ...

274

The impact of Human papilloma virus (HPV) infection on the development of cervical neoplasia  

OpenAIRE

The genesis of uterine cervix carcinoma has as central etiology the active infection of human papilloma virus (HPV), especially high oncogenic risk subtypes. However, this is a necessary, but not sufficient cause of virtually all cases of cervical cancer worldwide. At present, the proportion of cervical carcinomas attributed to HPV infection is estimated at 99%. It is considered that the pathogenesis of cervical carcinoma is the result of the proliferation of one or, at most, a few HPV-infect...

Vlad Gheorghita; Cornelia Amalinei; Ovidu Toma; Raluca Balan; Irina Draga Cruntu

2008-01-01

275

[Clear cell adenocarcinoma of the uterine cervix in a 17-year-old girl.  

Science.gov (United States)

Clear cell adenocarcinoma of the uterine cervix (CCEA) is a rare disease, accounting for only 1% of all cervical cancers. The disease in young women is linked to diethylstilbestrol (DES) exposure in utero. Following the ban of DES in 1979, CCEA rarely occurs in young women, but still remains a challenge in diagnosis and fertility preservation. We report on a 17-year-old girl, unexposed to DES, diagnosed with clear cell adenocarcinoma in a cervical polyp. PMID:25293863

Rønneberg, Elisabeth Thal; Lidang, Marianne; Palle, Connie

2014-09-01

276

Management of Precancerous Lesions of the Uterine Cervix according to Demographic Data  

OpenAIRE

Aims. Worldwide, cervical cancer is the fifth most deadly cancer in women, but screening prevents cancer by detecting precancerous lesions. The purpose of this study is to present the treatment profile for precancerous lesions of the uterine cervix, according to demographic data. Methods. An annual retrospective study was conducted in two public primary health care centres in Greece. The total number of Pap smears and colposcopies performed as well as the management of women with cervical...

Eleni-Maria Theodoraki; kyriakos Kioulafas; Dafni Kaitelidou; Lykourgos Liaropoulos; Olga Modinou

2010-01-01

277

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... I just wanted to highlight some of the technology, as we proceed along here. We have a ... make sure that we're not going too fast, slowly inject, only going forward into the uterine ...

278

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... Cardiac and Vascular Institute, we've performed almost 1,000 uterine fibroid embolizations. Fibroids are common, benign ... embolization procedure. More contrast, please. Thanks, Dr. Powell. One thing I did want to mention. You heard ...

279

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... what we're looking for is the initial pattern of blood flow. And, as you see that ... what we're looking at. Again, a typical pattern of a woman with symptomatic uterine fibroids. And ...

280

Abnormal Uterine Bleeding  

Science.gov (United States)

... hormones are the problem, doctors call the problem dysfunctional uterine bleeding, or DUB. Abnormal bleeding caused by ... by KA Oriel, MD, and S Schrager, MD (American Family Physician August 01, 1999, http://www.aafp.org/ ...

281

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... make sure that we're not going too fast, slowly inject, only going forward into the uterine ... blockage is relieved, we don't inject too fast. And so, typically it's a relatively low-pressure ...

282

Uterine Fibroid Embolization  

Medline Plus

Full Text Available Uterine Fibroid Embolization Baptist Health South Florida Miami, FL March 25, 2010 Good afternoon, and welcome to the Baptist Cardiac and Vascular Institute here in Miami, Florida. ...

283

Uterine ruptures in Yemen.  

OpenAIRE

OBJECTIVES To study the incidence, risk factors, clinical presentation, maternal morbidity and mortality, and perinatal mortality in cases with ruptured gravid uterus. METHODS All cases with diagnosis of uterine rupture at Saudi Hospital at Hajjah, Yemen during 5-years period from April 1999 to March 2004 were studied. Detailed informations were obtained by reviewing hospital records. RESULTS Out of the total number of deliveries during the period (N=5547), 60 cases had uterine...

Diab, Abdalla E.

2005-01-01

284

Uterine Leiomyoma: Hysterosalpingographic Appearances  

OpenAIRE

Uterine leiomyoma is the most common benign tumor of genital tract. The etiology of myomasis unknown. Leiomyoma shows a broad spectrum of radiographic appearances depending on thenumber, size, and location of the tumor. The diagnostic method for uterine leiomyomas is basedprimarily on the clinical situation. Despite of the varied diagnostic options such as; transvaginalsonography, sonohysterography, hysteroscopy, laparoscopy and MRI; hysterosalpingography isstill one of the valuable imaging m...

Firoozeh Ahmadi; Fatemeh Zafarani; Maryam Niknejadi; Ahmad Vosough

2008-01-01

285

Uterine fibroids: current perspectives  

Directory of Open Access Journals (Sweden)

Full Text Available Aamir T Khan,1 Manjeet Shehmar,1 Janesh K Gupta21Birmingham Women's Hospital, Edgbaston, Birmingham, UK; 2Academic Department of Obstetrics and Gynaecology, University of Birmingham, Birmingham, UKAbstract: Uterine fibroids are a major cause of morbidity in women of a reproductive age (and sometimes even after menopause. There are several factors that are attributed to underlie the development and incidence of these common tumors, but this further corroborates their relatively unknown etiology. The most likely presentation of fibroids is by their effect on the woman's menstrual cycle or pelvic pressure symptoms. Leiomyosarcoma is a very rare entity that should be suspected in postmenopausal women with fibroid growth (and no concurrent hormone replacement therapy. The gold standard diagnostic modality for uterine fibroids appears to be gray-scale ultrasonography, with magnetic resonance imaging being a close second option in complex clinical circumstances. The management of uterine fibroids can be approached medically, surgically, and even by minimal access techniques. The recent introduction of selective progesterone receptor modulators (SPRMs and aromatase inhibitors has added more armamentarium to the medical options of treatment. Uterine artery embolization (UAE has now been well-recognized as a uterine-sparing (fertility-preserving method of treating fibroids. More recently, the introduction of ultrasound waves (MRgFUS or radiofrequency (VizAblate™ and Acessa™ for uterine fibroid ablation has added to the options of minimal access treatment. More definite surgery in the form of myomectomy or hysterectomy can be performed via the minimal access or open route methods. Our article seeks to review the already established information on uterine fibroids with added emphasis on contemporary knowledge.Keywords: leiomyoma, menorrhagia, ultrasonography, selective progesterone receptor modulators, uterine artery embolization, myomectomy

Khan AT

2014-01-01

286

Subserous Uterine Leiomyoma  

OpenAIRE

Uterine fibroids are the most common pelvic tumor. The growth of a fibroid seems to depend on the hormone estrogen. As long as a woman with fibroids is menstruating, the fibroids will probably continue to grow, usually slowly. Management of uterine myomas may involve one of the following approaches or a combination thereof: expectant management, medical management. A case of subserous leiomyoma in a 20-year old, virgin is hereby presented. She underwent myomectomy for a preoperative adnexal m...

Rusda, Muhammad; Adrian

2010-01-01

287

Management of Uterine Sarcomas  

OpenAIRE

Uterine sarcomas are rare malignant tumors characterized by a great clinical and histopathological diversity. The aim of this work is to analyze the difficulties of diagnosis, therapeutic and prognosis posed by these tumors. Thirty-seven patients with uterine sarcoma, collected in the service Radiotherapy and Oncology, University Ibn Rochd of Casablanca between January 2000 and December 2007 were included in this study retrospective. The average patient age was 50 years (17-76). The bleeding ...

Asmaa Naim; Zineb Bouchbika; Mohamed Aksim; Nadia Benchakroune; Hassan Jouhadi; Nezha Tawfiq; Souha Sahraoui; Soumia Zamiati; Abdelatif Benider

2012-01-01

288

Cervical cancer.  

Science.gov (United States)

Behavioral and psychosocial factors affect all aspects of cervical cancer control, from prevention to posttreatment rehabilitation. Behavioral scientists gathered at the Second International Conference on Cervical Cancer (Houston, TX, April 11-14, 2002) reviewed selected studies of behavioral factors related to cervical cancer, including women's receptivity to emerging cervical cancer screening and diagnostic technologies, factors that influence adherence to follow-up colposcopy recommendations, and cervical cancer survivors' quality of life. Researchers reported that reduced distress during examinations with new technology may improve adherence to cervical cancer screening recommendations. Until new technology becomes mainstream, research shows that distress is reduced and adherence improves when health care providers match interventions to patients' informational processing styles. Investigations of survivors' quality of life report conflicting findings, but studies indicate that survivors experience anger over reproductive loss, loss of interest in sex, and perhaps a greater vulnerability to sexual dysfunction compared with survivors of other cancers. Survivors also report a need for posttherapy support programs. Primary prevention of cervical cancer should remain a priority as research in behavioral interventions and barriers to screening, especially among vulnerable populations, moves forward. PMID:14603537

Basen-Engquist, Karen; Paskett, Electra D; Buzaglo, Joanne; Miller, Suzanne M; Schover, Leslie; Wenzel, Lari B; Bodurka, Diane C

2003-11-01

289

Prediction of lymph node status in uterine cervical cancer with {sup 18}FDG-PET/CT-value of primary tumor uptake; Determination par TEP-TDM au {sup 18}FDG du statut ganglionnaire dans les cancers du col uterin - interet de la mesure du SUV de la tumeur primitive  

Energy Technology Data Exchange (ETDEWEB)

Purpose. To evaluate the value of {sup 18}F-fluoro-2-deoxyglucose (F.D.G.) PET-CT and maximal standardized uptake value (SUV{sub max}) of the primary tumor for lymph node staging in cervical cancer. Materials and methods. This retrospective study involved a series of 18 consecutive patients who had benefited from PET-CT and MRI at initial staging for a stage IB or higher cervical carcinoma. The SUV{sub max} of each primary tumor was measured retrospectively. All patients had been previously treated by radio chemotherapy. Lymph node status was obtained in 12 of 18 cases. Results. The sensitivity and specificity for determining lymph node status was 80 and 86%, respectively, for PET-CT, and 80 and 71% for MRI. In 16.6% of cases, PET-CT revealed unknown sus-diaphragmatic lesions. SUV{sub max} of the primary tumor was significantly higher in the N+ than in the N- group (15.6 {+-}1.6 vs 8.5{+-}3.9, p < 0.01). The optimal threshold was determined to be 10.8 from ROC analysis. Conclusion. When staging with F.D.G. PET-CT, SUV{sub max} of a primary cervical cancer seems to be a good predictor of lymph node status. This could lead to an intensification of treatment for patients whose SUV{sub max} is higher than 10.8. A prospective study would allow to assess a potential benefit of treatment intensification for patients with SUV{sub max} higher than 10.8. (authors)

Merlin, C.; Cachin, F.; Kelly, A.; Mestas, D.; Freitas, D. de; Maublant, J. [Clermont-Ferrand-1 Univ., Centre Jean-Perrin, Service de Medecine Nucleaire, 63 (France)

2008-06-15

290

Dosimetric comparison of IMRT and modulated arc-therapy techniques in the treatment of cervical cancers; Comparaison dosimetrique des techniques de RCMI et d'arctherapie modulee dans le traitement des cancers du col uterin  

Energy Technology Data Exchange (ETDEWEB)

The authors report the dosimetric comparison of two techniques used for the treatment of cervical cancers: the intensity-modulated conformational radiotherapy (IMRT) with static beams and modulated arc-therapy with RapidArc. The treatment plans of 15 patients have been compared. The clinical target volume (CTV) comprises the gross target volume, the cervix, the upper third of the vagina, and ganglionary areas. The previsional target volume comprises the clinical target volume and a one centimetre margin. Organs at risk are rectum, bladder, intestine and bone marrow. Arc-therapy seems to provide a better sparing of intestine that IMRT, while maintaining a good coverage of the previsional target volume and decreasing treatment duration. Short communication

Renard-Oldrini, S.; Charra-Brunaud, C.; Tournier-Rangeard, L.; Huger, S.; Marchesi, V.; Bouziz, D.; Peiffert, D. [Centre Alexis-Vautrin, Nancy (France)

2011-10-15

291

RAPIDARC (RA) in the uterine cervical cancer; dosimetric gain vs 3D-Crt; RAPIDARC (RA) en el cancer de cervix uterino; ganancia dosimetrica vs 3D-CRT  

Energy Technology Data Exchange (ETDEWEB)

This work aims to quantitatively assess RAPIDARC (RA) treatments versus three dimensional-Conformal Radiation Therapy with field to field technique (3D-Crt-Fin F). 11 patients with cervical cancer treated at our institution radically or adjuvant clinical stages I-III B were evaluated. The prescribed dose was 50 Gy (2 Gy / Fr). The RA plans consisted of two isocentric complete arcs and conformational plans of 4 isocentric fields (previous, subsequent, right side and left side) with 3D-Crt-Fin F technique; both cases carried out ??in the Eclipse version 10 planner with calculation algorithm analytical anisotropic algorithm (AAA) and volumetric optimization software (for VMAT plans). Homogeneity indices (Hi), conformity indices (CI) Sigma indices (S-Index), monitor units (MU) and the time required for each treatment were compared. The mean age was 52 years (32-65) of the 11 patients 9 were clinical stages I-II B. The Hi varied from 0.052 for RA to 0.163 for 3D-Crt-Fin F (p = 0.009), and the CI between 1.005 and 1.35 (p = 0.26), the S-index from 1.2 to 3.7 (p = 0.001) and the H-index of 1.08 to 1.15 (p = 0.24). All dose limits in risk organs were met with a significant difference in the RA plans versus 3D-Crt-Fin F. In patients with cervical cancer the treatment plans quality with the indices aforementioned seems to be better with the RA technique, being observed a significant reduction of radiation to surrounding organs. (author)

Ramirez, J.; Garcia, B.; Quispe, K.; Gonzales, A.; Marquina, J., E-mail: jose.ramirez@aliada.com.pe [Clinica Aliada, Oncologia Integral, Av. Jose Galvez Barrenechea 1044, San Isidro, Lima (Peru)

2014-08-15

292

Cervical Cancer  

Science.gov (United States)

... Stage 0. Stage 0 also is called noninvasive cervical cancer or carcinoma in situ. In Stage 0, cancer cells are ... of treatment? Invasive cancer of the cervix is treated with surgery (hysterectomy) , radiation therapy, and chemotherapy (the ...

293

Cervical dysplasia  

Science.gov (United States)

... are not cancer. But they can lead to cancer of the cervix if not treated. ... Gynecologists. Practice Bulletin No. 131: Screening for cervical cancer. ... screening, diagnostic techniques, management. In: Lentz ...

294

Cervical cancer  

Science.gov (United States)

... Doroshow JH, et al., eds. Abeloff’s Clinical Oncology . 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2013:chap 87. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Cervical cancer. Version ...

295

How Are Uterine Fibroids Diagnosed?  

Science.gov (United States)

... Trials Resources and Publications En Español How are uterine fibroids diagnosed? Skip sharing on social media links Share ... you probably won’t know that you have uterine fibroids. Sometimes, health care providers find fibroids during a ...

296

Radiculopatía cervical  

Directory of Open Access Journals (Sweden)

Full Text Available La patología cervical traumática y su relación con el quehacer de la medicina legal tiene gran importancia y vigencia, principalmente cuando se hace necesario realizar valoraciones a pacientes con alteraciones cervicales y se debe definir si estas están en relación a un trauma determinado o repetitivo en el tiempo como puede ocurrir en algunos casos de riesgos de trabajo. El médico forense debe estar muy bien preparado, conocer la anatomía cervical y de los miembros superiores, realizar un interrogatorio y un examen físico neurológico exhaustivo para orientar las posibilidades diagnósticas; es fundamental además el análisis de los estudios diagnósticos. En este caso en particular se realizará una revisión de la radiculopatía cervical, su fisiopatología, mecanismos de producción y las implicaciones médico legales al realizar la valoración en pacientes con cervicobraquialgiaTraumatic cervical pathology and its relationship to the work of forensic medicine is of great importance and relevance, especially when it is necessary to make assessments in patients with cervical changes and must be defined if they are in relation to a specific trauma or repetitive in time as may occur in some cases of occupational hazards. The medical examiner must be very well prepared, know the anatomy of the cervical and upper limbs, perform an examination and a thorough neurological physical examination to guide the diagnostic possibilities, it is also fundamental analysis of diagnostic studies. In this particular case there will be a review of cervical radiculopathy, pathophysiology, mechanisms of production and the medico-legal implications when doing the assessment in patients with cervical braquial pain

Adriana Murillo Calderón

2012-09-01

297

Radiculopatía cervical  

Scientific Electronic Library Online (English)

Full Text Available SciELO Costa Rica | Language: Spanish Abstract in spanish La patología cervical traumática y su relación con el quehacer de la medicina legal tiene gran importancia y vigencia, principalmente cuando se hace necesario realizar valoraciones a pacientes con alteraciones cervicales y se debe definir si estas están en relación a un trauma determinado o repetiti [...] vo en el tiempo como puede ocurrir en algunos casos de riesgos de trabajo. El médico forense debe estar muy bien preparado, conocer la anatomía cervical y de los miembros superiores, realizar un interrogatorio y un examen físico neurológico exhaustivo para orientar las posibilidades diagnósticas; es fundamental además el análisis de los estudios diagnósticos. En este caso en particular se realizará una revisión de la radiculopatía cervical, su fisiopatología, mecanismos de producción y las implicaciones médico legales al realizar la valoración en pacientes con cervicobraquialgia Abstract in english Traumatic cervical pathology and its relationship to the work of forensic medicine is of great importance and relevance, especially when it is necessary to make assessments in patients with cervical changes and must be defined if they are in relation to a specific trauma or repetitive in time as may [...] occur in some cases of occupational hazards. The medical examiner must be very well prepared, know the anatomy of the cervical and upper limbs, perform an examination and a thorough neurological physical examination to guide the diagnostic possibilities, it is also fundamental analysis of diagnostic studies. In this particular case there will be a review of cervical radiculopathy, pathophysiology, mechanisms of production and the medico-legal implications when doing the assessment in patients with cervical braquial pain

Adriana, Murillo Calderón.

2012-09-01

298

Conhecimento das mulheres sobre o câncer cérvico-uterino - DOI: 10.4025/actascihealthsci.v26i2.1582 Women’s knowledge of cervical uterine cancer - DOI: 10.4025/actascihealthsci.v26i2.1582  

Directory of Open Access Journals (Sweden)

Full Text Available O objetivo deste estudo foi verificar o conhecimento que as mulheres têm sobre o exame preventivo do câncer cérvico-uterino, sua importância e os sentimentos delas em relação ao exame, em uma tentativa de melhor compreender a prática da prevenção. Trata-se de estudo descritivo exploratório. As mulheres demonstraram que, em relação ao exame, o medo e a vergonha são os maiores sentimentos. Em relação à importância do exame, a maioria relatou ser a prevenção e a descoberta precoce da doença o fator mais importante. Sobre o conhecimento da doença, relataram ter ouvido falar, visto na TV, mas o medo da doença e até do nome câncer é maior que a necessidade de realizar o exame.O que impede a realização do exame é o medo do resultado e a falta de tempo. Os dados permitiram concluir que é necessário aumentar a cobertura dos exames; orientar as mulheres através de campanhas e, ainda, desmistificar a técnica e os resultados dos mesmos.The aim of this work was to verify women’s knowledge of cervical uterine cancer prevention exam, its importance and women’s feelings towards it. This was done in order to better understand the prevention practice. This is an exploratory descriptive study. The women’s major feelings towards this exam are fear and shame. Regarding this exam importance, most of them said that the prevention and the precocious discovery of the illness are the most important factors. Knowledge of the disease was acquired through conversations and TV programs, even though fear of the disease is greater than the need to undertake the exams. The latter is impaired by fear regarding their result and by lack of time to undertake them. Data show that exam coverage should be broadened; more orientation should be given through campaigns; technique and exam results should be demystified.

Maria Dalva de Barros Carvalho

2004-04-01

299

A rare case of minimal deviation adenocarcinoma of the uterine cervix in a renal transplant recipient.  

LENUS (Irish Health Repository)

INTRODUCTION: We report the first described case of minimal deviation adenocarcinoma of the uterine cervix in the setting of a female renal cadaveric transplant recipient. MATERIALS AND METHODS: A retrospective review of this clinical case was performed. CONCLUSION: This rare cancer represents only about 1% of all cervical adenocarcinoma.

Fanning, D M

2012-02-01

300

A rare case of minimal deviation adenocarcinoma of the uterine cervix in a renal transplant recipient.  

LENUS (Irish Health Repository)

INTRODUCTION: We report the first described case of minimal deviation adenocarcinoma of the uterine cervix in the setting of a female renal cadaveric transplant recipient. MATERIALS AND METHODS: A retrospective review of this clinical case was performed. CONCLUSION: This rare cancer represents only about 1% of all cervical adenocarcinoma.

Fanning, D M

2009-02-03

301

Radiation therapy of cancer of the uterine cervix in Northern Ireland  

OpenAIRE

From 1976 to 1980, 275 patients with invasive uterine cervical cancer were treated at the Northern Ireland Radiotherapy Centre. Most patients had combined intracavitary and external radiotherapy. Only 26% presented with clinical Stage 1 disease; there were more of these patients aged 30-39.

Houston, R. F.

1987-01-01

302

Pregnancy after uterine arterial embolization  

OpenAIRE

OBJECTIVE: To evaluate pregnancy outcomes, complications and neonatal outcomes in women who had previously undergone uterine arterial embolization. METHODS: A retrospective study of 187 patients treated with uterine arterial embolization for symptomatic uterine fibroids between 2005-2008 was performed. Uterine arterial embolization was performed using polyvinyl alcohol particles (500-900 mm in diameter). Pregnancies were identified using screening questionnaires and the study database. RESULT...

Bonduki, Cla?udio E.; Paulo C Feldner, Jr; Juliana da Silva; Castro, Rodrigo A.; Sartori, Marair G. F.; Gira?o, Manoel J. B. C.

2011-01-01

303

Intensity of cervical inflammatory reaction as a risk factor for recurrence of carcinoma of the uterine cervix in stages IB and IIA / Intensidade da reação inflamatória cervical como fator de risco para recorrência do carcinoma do colo do útero nos estádios IB e IIA  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese CONTEXTO E OBJETIVO: A intensidade da reação inflamatória é citada como possível fator de risco para recorrência do carcinoma do colo do útero (CCU). Alguns autores observaram aumento do risco com reação inflamatória fraca, enquanto outros descreveram o oposto. Este estudo procurou avaliar os fatore [...] s de risco para recorrência do CCU em estádios iniciais (IB e IIA), considerando na análise a reação inflamatória. TIPO DE ESTUDO E LOCAL: Coorte retrospectiva, no Centro de Tratamento e Pesquisa Hospital A. C. Camargo (Hospital do Câncer). MÉTODOS: Estudaram-se 289 pacientes com diagnóstico de CCU (estádios IB e IIA) submetidas à cirurgia radical entre 1980 e 1999. Realizou-se a coleta de dados nos prontuários. Os cortes histológicos dos tumores e dos linfonodos foram revistos em 247 casos. As taxas de sobrevida livre de doença em cinco anos foram calculadas pelo método de Kaplan-Meier e as curvas comparadas pelo teste de log-rank. Para a análise multivariada empregou-se o modelo de riscos proporcionais de Cox. A estimativa do risco de recorrência foi o hazard ratio (HR). RESULTADOS: Registraram-se 43 recorrências. A análise multivariada identificou os seguintes fatores de risco independentes para recorrência: número de linfonodos pélvicos metastáticos (1 linfonodo: HR = 3,3 [1,3-8,3]; 2 ou 3 linfonodos: HR = 5,3 [1,5-18,6]; 4 ou mais linfonodos: HR=7,6 [1,7 - 33,2]), profundidade de invasão do tumor (terço profundo: HR = 2,1 [1,1-4,1]) e intensidade da reação inflamatória no colo do útero (ausente ou leve: HR = 2,5 [1,1-5,7]). CONCLUSÃO: Este estudo identificou a reação inflamatória ausente ou de intensidade leve como fatores de risco independentes para recorrência. Os outros fatores de risco foram o número de linfonodos pélvicos metastáticos e a invasão do terço profundo do colo do útero. Abstract in english CONTEXT AND OBJECTIVE: Inflammatory reaction intensity has been indicated as a possible recurrence risk factor in carcinoma of the uterine cervix. Some authors observed greater risk with weak inflammatory reaction, while others described the opposite. This study aimed to evaluate risk factors for in [...] itial-stage uterine cervix carcinoma recurrence (IB and IIA), considering inflammatory reaction intensity. DESIGN AND SETTING: Retrospective cohort at Hospital do Câncer A. C. Camargo. METHODS: 289 patients with diagnosed uterine cervix carcinoma (stages IB and IIA) who underwent radical surgery between 1980 and 1999 were studied. Data were collected from medical records. Histological sections from tumors and lymph nodes could be reviewed in 247 cases. Five-year disease-free survival rates were calculated using the Kaplan-Meier method and curves were compared using the log-rank test. Cox's proportional-hazards model was used for multivariate analysis. Recurrence risk was estimated using hazard ratios (HR). RESULTS: Forty-three recurrences were found. Multivariate analysis identified the following independent recurrence risk factors: number of metastatic pelvic lymph nodes (one lymph node: HR = 3.3 [1.3-8.3]; two or three: HR = 5.3 [1.5-18.6]; four or more: HR = 7.6 [1.7-33.2]), tumor invasion depth (deepest third: HR = 2.1 [1.1-4.1]) and inflammatory reaction intensity in the uterine cervix (absent or slight: HR = 2.5 [1.1-5.7]). CONCLUSION: This study identified that absent or slight inflammatory reaction was an independent risk factor for recurrence. The other risk factors were the number of metastatic pelvic lymph nodes and invasion of the deepest third of the uterine cervix.

José Humberto Tavares Guerreiro, Fregnani; Fernando Augusto, Soares; Pablo Roberto, Novik; Ademar, Lopes; Maria do Rosário Dias de Oliveira, Latorre.

2007-07-01

304

Cervical thymoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese CONTEXTO: O timoma cervical é neoplasia primitiva do timo. Sua incidência é muito rara. Esta doença apresenta maior incidência em pacientes do sexo feminino, entre a quarta e sexta décadas. RELATO DE CASO: Apresentamos o caso de uma paciente do sexo feminino, 54 anos, com timoma cervical. Durante o [...] período de dois anos e meio de investigação teve evolução assintomática com crescimento progressivo do nódulo cervical, próximo à tireóide. A paciente não apresentou alterações dos exames de função tireoidiana ou dos exames subsidiários realizados. O diagnóstico de timoma cervical foi realizado no intra-operatório sendo conclusivo com o estudo anatomopatológico da peça retirada. O timoma cervical é raro, com difícil diagnóstico pré-operatório. Atualmente utiliza-se métodos complementares para o diagnóstico preciso como: a cintilografia com Tálio 201, o Tecnésio 99 e o Iodo 131, além da ressonância nuclear magnética e, principalmente, realizando o estudo e classificação histopatológica. Abstract in english CONTEXT: Cervical thymoma is a primitive thymic neoplasia. It is very rare. This disease presents higher incidence in female patients in their 4th to 6th decade of life. We present a case report of a cervical thymoma CASE REPORT: 54-year-old female patient, caucasian, with no history of morbidity, p [...] resenting a left cervical nodule close to the thyroid gland. During the 30 months of investigation a left cervical nodule grew progressively next to the thyroid while the patient showed no symptoms, making accurate diagnosis difficult. Tests on her thyroid function did not show changes, nor were there changes in any subsidiary tests. The diagnosis of the disease was made intra-operatively through total thyroid individualization. The results were confirmed by the histological findings from the ressected material. Cervical thymoma is a very rare disease, with difficult preoperatory diagnosis. Some additional study methods which are employed today are thallium 201, technetium 99 and iodine 131 scintigraphy, magnetic nuclear resonance and especially histopathological findings and classification.

Abrão, Rapoport; Claudiane Ferreira, Dias; João Paulo Aché de, Freitas; Ricardo Pires de, Souza.

1999-05-06

305

Uterine fibroid embolization.  

Science.gov (United States)

Uterine fibroid embolization (UFE) is a minimally invasive therapy for the treatment of symptomatic uterine fibroids and offers an alternative to conventional myomectomy and hysterectomy. This review focuses on recent publications evaluating UFE and concludes that it is a safe treatment option, providing substantial improvement in both health-related quality of life and symptom control for most patients, with a very low rate of major complications. The durability of these outcomes appears similar to those obtained with myomectomy; however, a direct comparative long-term study is needed. Recent comparative studies have begun to provide more insight in to UFE outcomes compared with outcomes achieved with myomectomy and hysterectomy. UFE should be considered a first line therapy for women with symptomatic uterine fibroids. Additional research will continue to provide us with information as to the ideal candidates for UFE and may provide us with better tools to predict patient outcomes. PMID:17145478

White, Amy M; Spies, James B

2006-03-01

306

Uterine vascular lesions.  

Science.gov (United States)

Vascular lesions of the uterus are rare; most reported in the literature are arteriovenous malformations (AVMs). Uterine AVMs can be congenital or acquired. In recent years, there has been an increasing number of reports of acquired vascular lesions of the uterus following pregnancy, abortion, cesarean delivery, and curettage. It can be seen from these reports that there is confusion concerning the terminology of uterine vascular lesions. There is also a lack of diagnostic criteria and management guidelines, which has led to an increased number of unnecessary invasive procedures (eg, angiography, uterine artery embolization, hysterectomy for abnormal vaginal bleeding). This article familiarizes readers with various vascular lesions of the uterus and their management. PMID:24340126

Vijayakumar, Abhishek; Srinivas, Amruthashree; Chandrashekar, Babitha Moogali; Vijayakumar, Avinash

2013-01-01

307

Uterine Vascular Lesions  

Science.gov (United States)

Vascular lesions of the uterus are rare; most reported in the literature are arteriovenous malformations (AVMs). Uterine AVMs can be congenital or acquired. In recent years, there has been an increasing number of reports of acquired vascular lesions of the uterus following pregnancy, abortion, cesarean delivery, and curettage. It can be seen from these reports that there is confusion concerning the terminology of uterine vascular lesions. There is also a lack of diagnostic criteria and management guidelines, which has led to an increased number of unnecessary invasive procedures (eg, angiography, uterine artery embolization, hysterectomy for abnormal vaginal bleeding). This article familiarizes readers with various vascular lesions of the uterus and their management. PMID:24340126

Vijayakumar, Abhishek; Srinivas, Amruthashree; Chandrashekar, Babitha Moogali; Vijayakumar, Avinash

2013-01-01

308

Advanced small cell carcinoma of the uterine cervix treated by neoadjuvant chemotherapy with irinotecan and cisplatin followed by radical surgery  

OpenAIRE

Small cell carcinoma of the uterine cervix is a rare form of cervical cancer characterized by extreme aggressiveness and poor prognosis because of its rapid growth, frequent distant metastases, and resistance to conventional treatment modalities. We report here a case of advanced-stage small cell carcinoma of the uterine cervix treated by neoadjuvant chemotherapy, followed by radical surgery, resulting in locoregional disease control. A 39-year-old Japanese woman was diagnosed as having stage...

Hisashi Narahara; Noriyuki Takai; Harunobu Matsumoto; Chihiro Kiyoshima; Masakazu Nishida; Mamiko Okamoto; Tomoko Hirakawa; Kaei Nasu

2011-01-01

309

Beach Erosion  

Science.gov (United States)

The Beach Erosion site of the WhyFiles (last mentioned in the August 9, 1996 Scout Report), a project funded by the graduate school of the University of Wisconsin-Madison, has been recently updated. Its newest addition includes a story about the population of the tiny Pacific Island nation of Tuvalu that is preparing to abandon its home due to rising sea levels. The site takes a look at this subject and the resulting increased beach erosion that takes place around the world. Visitors can read about the physical processes of beach erosion, view a QuickTime movie of a house falling into the ocean, and more. The site includes good descriptions, photographs, and links to additional information (although some were broken at the time of this annotation), giving interested readers insight into this widespread phenomenon.

310

Surgical Methods for the Treatment of Uterine Fibroids – Risk of Uterine Sarcoma and Problems of Morcellation: Position Paper of the DGGG  

Science.gov (United States)

The appropriate surgical technique to treat patients with uterine fibroids is still a matter of debate as is the potential risk of incorrect treatment if histological examination detects a uterine sarcoma instead of uterine fibroids. The published epidemiology for uterine sarcoma is set against the incidence of accidental findings during surgery for uterine fibroids. International comments on this topic are discussed and are incorporated into the assessment by the German Society for Gynecology and Obstetrics (DGGG). The ICD-O-3 version of 2003 was used for the anatomical and topographical coding of uterine sarcomas, and the “Operations- und Prozedurenschlüssel” (OPS) 2014, the German standard for process codes and interventions, was used to determine surgical extirpation methods. Categorical qualifiers were defined to analyze the data provided by the Robert Koch Institute (RKI), the German Federal Bureau of Statistics (DESTATIS; Hospital and Causes of Death Statistics), the population-based Cancer Register of Bavaria. A systematic search was done of the MEDLINE database and the Cochrane collaboration, covering the period from 1966 until November 2014. The incidence of uterine sarcoma and uterine fibroids in uterine surgery was compared to the literature and with the different registries. The incidence of uterine sarcoma in 2010, standardized for age, was 1.53 for Bavaria, or 1.30 for every 100?000 women, respectively, averaged for the years 2002–2011, and 1.30 for every 100?000 women in Germany. The mean incidence collated from various surveys was 2.02 for every 100?000 women (0.35–7.02; standard deviation 2.01). The numbers of inpatient surgical procedures such as myoma enucleation, morcellation, hysterectomy or cervical stump removal to treat the indication “uterine myoma” have steadily declined in Germany across all age groups (an absolute decrease of 17?% in 2012 compared to 2007). There has been a shift in the preferred method of surgical access from an abdominal/vaginal approach to endoscopic or endoscopically assisted procedures to treat uterine fibroids, with the use of morcellation increasing by almost 11?000 coded procedures in 2012. Based on international statements (AAGL, ACOG, ESGE, FDA, SGO) on the risk of uterine sarcoma as an coincidental finding during uterine fibroid surgery and the associated risk of a deterioration of prognosis (in the case of morcellation procedures), this overview presents the opinion of the DGGG in the form of four Statements, five Recommendation and four Demands. PMID:25797958

Beckmann, M. W.; Juhasz-Böss, I.; Denschlag, D.; Gaß, P.; Dimpfl, T.; Harter, P.; Mallmann, P.; Renner, S. P.; Rimbach, S.; Runnebaum, I.; Untch, M.; Brucker, S. Y.; Wallwiener, D.

2015-01-01

311

Incidencia y tendencia de lesiones cervicouterinas en mujeres pinareñas de 10-24 años. 2003-2012 / Incidence and tendency of cervical-uterine lesions in Pinar del Río 10-to-14-year-old women, 2003-2012  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: se han detectado lesiones premalignas y malignas en mujeres menores de 25 años, pero no se conoce exactamente la magnitud del problema en Pinar del Río. Objetivo: evaluar la incidencia y la tendencia de lesiones premalignas y malignas del cuello uterino en mujeres pinareñas menores de [...] 25 años según características demográficas en el período 2003-2012. Material y método: se realizó un estudio retrospectivo, longitudinal para conocer la incidencia anual de lesiones premalignas y malignas del cuello uterino en mujeres pinareñas menores de 25 años. La muestra estuvo conformada por el resultado de las biopsias realizadas a estas jóvenes en ese período. Resultados: la incidencia anual por 10000 mujeres 10-24 años fue de 8.8 para las NIC I; 3,1 en NIC II; 1,6 para las NIC III + CIS, 0.07 para el microinvasor, 0.03 para el invasor Ib y 0.02 para el invasor estadio II. No se detectaron ni estadios superiores de la variedad epidermoide y adenocarcinomas endocervicales. La incidencia anual para cada una de las lesiones mostró una tendencia al incremento sobre todo para las NIC I. De 1198 biopsias realizadas en este grupo etario solamente se detectaron 7 carcinomas epidermoides invasores cervicales en 10 años, 0.7 anuales, con tasa de 5.8 x cada 1000 mujeres de 10-24 años. Conclusiones: la incidencia detectada de lesiones malignas en este grupo no justificaría comenzar la realización del pesquisaje citológico antes de los 25 años, ya que el costo sería alto y el beneficio mínimo. Abstract in english Introduction: malignant and pre-malignant lesions have been localized in women less than 25 years, but the exact enormity of the problem in Pinar del Río is not known. Objective: to evaluate the tendency and incidence of malignant and pre-malign cervical lesions in Pinar women less than 25 years old [...] according to demographic characteristics, in the period 2003-2012. Material and method: a retrospective, cross-sectional study was carried out, in order to know the annual incidence of malign and pre-malign cervical lesions in Pinar women younger than 25 years. The sample comprised the results of biopsies made of those women in that period. Results: the annual incidence in 10,000 women from 10-24 years old was 8.8 for CIN1, 3.1 for CIN2, 1.6 for CIN3 + CIS (carcinoma in situ), 0.07 for de micro-invasive, 0.03 for the invasive Ib, and 0.02 for the invasive stage II. Stages over neither epidermoidal nor endocervical adenocarcinomas were detected. The annual incidence in each lesion proved increasing particularly for NIC1 cases. Out of 1,198 biopsies made on this age group, only 10 invasive epidermoidal carcinomas were detected in ten years, 0.7 annually, with a proportion of 5.8 per 1,000 women between 10-24 years of age. Conclusions: The tendency of malignant lesions detected in this group would not justify starting the cytological screening before the 25 years of age, since the cost would high and the benefit would be minimal.

José Guillermo, Sanabria Negrín; Victor Enrique, Salgueiro Medina; Magalys Brígida, Abreu Mérida; Agustín, Lemus Sarracino; Raydel, Marrero Fernández.

2014-02-01

312

Evidence for benefits from treating cervical ectopy: literature review / Evidências de benefícios no tratamento de ectopia do colo do útero: revisão de literatura  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese CONTEXTO E OBJETIVO: A ectopia do colo do útero é hoje considerada um fenômeno fisiológico, mas parece ainda haver uma forte tendência no sentido da intervenção (tratamento). Este estudo se propõe a realizar revisão da literatura buscando evidências de benefícios conseqüentes ao tratamento da ectopi [...] a. MÉTODOS: Pesquisa nas bases Medical Literature Analysis and Retrieval Sysem Online (Medline), Excerpta Medica Database (Embase), Literatura Latino-Americane e do Caribe em Ciências da Saúde (Lilacs), Biblioteca Cochrane e seis livros especializados. RESULTADOS: A revisão mostrou que: 1) existe provavelmente associação de ectopia com infecção cervical por Chlamydia trachomatis, pelo vírus HPV e maior risco de soroconversão para HIV; 2) existe provavelmente associação entre ectopia e neoplasia intra-epitelial cervical; 3) existe associação com mucorréia e nictúria; 4) não existem evidências sobre associação entre ectopia e câncer de colo do útero nem sobre proteção contra este câncer proporcionada pelo tratamento da ectopia. CONCLUSÕES: 1) Não foram encontrados na literatura dados que justifiquem o tratamento rotineiro da ectopia; 2) O tratamento pode ser utilizado para tratar sintomas associados à ectopia, porém mais sintomas são atribuídos à ectopia do que se pôde confirmar em um estudo controlado; 3) Seriam necessários novos estudos para testar a hipótese de proteção contra o câncer de colo proporcionada pelo tratamento. Abstract in english CONTEXT AND PURPOSE: Uterine cervical ectopy (cervical erosion) is today considered to be a physiological condition, but there still seems to be a strong tendency towards treating it. The purpose of this study was to review the medical literature for evidence regarding benefits from treating cervica [...] l ectopy. METHODS: The following databases were reviewed: Medical Literature Analysis and Retrieval System Online (Medline), Excerpta Medica Database (Embase), Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) and Cochrane Library databases. In addition, six medical textbooks were consulted. RESULTS: The review showed that: 1) there is probably an association between ectopy and higher risk of Chlamydia trachomatis, human papillomavirus and human immunodeficiency virus infection; 4) there is probably an association between ectopy and cervical intraepithelial neoplasia; 5) there is an association between ectopy and mucous discharge and nocturia; and 6) there is no evidence of an association between ectopy and cervical cancer, or of protection against cervical cancer associated with ectopy treatment. CONCLUSIONS: 1) No data were found in the medical literature to support routine treatment for ectopy; 2) Treatment could be recommended for symptom relief, but more symptoms are attributed to ectopy than could be demonstrated in a controlled study; 3) Further studies to test the hypothesis of protection against cervical cancer associated with treatment are necessary.

Luís Carlos, Machado Junior; Ana Sílvia Whitaker, Dalmaso; Heráclito Barbosa de, Carvalho.

2008-03-01

313

What Is Uterine Sarcoma?  

Science.gov (United States)

... starts in the cervix, it is called a cervical carcinoma . Carcinomas starting in the endometrium, the lining of ... but since they are more aggressive and are treated differently from low-grade tumors, they are now ...

314

Demonstration of an epitope of the transferrin receptor in human cervical epithelium--a potentially useful cell marker.  

OpenAIRE

The distribution of an epitope of the transferrin receptor in the human uterine cervical epithelium has been investigated. Immunohistochemical staining, both immunofluorescent and immunoperoxidase, was performed on biopsy specimens and cytological samples from normal, dysplastic, and neoplastic cervical epithelia using the monoclonal OKT9 antibody. The results of staining 145 cervical biopsy specimens with OKT9 showed widespread staining in all malignant epithelia and most severely dysplastic...

Lloyd, J. M.; O Dowd, T.; Driver, M.; Tee, D. E.

1984-01-01

315

ANALISIS CRITICO DEL MANEJO DE LA INCOMPETENCIA CERVICAL  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish La incompetencia cervical se caracteriza por la dilatación progresiva del cuello uterino en ausencia de contracciones uterinas. Esta condición es causa de aborto de segundo trimestre y parto prematuro. Clásicamente el tratamiento ha sido el cerclaje cervical, cuya utilidad, sin embargo, no ha sido d [...] emostrada. La evidencia disponible, y el uso clínico habitual sugiere que el grupo de pacientes con historia clínica característica de incompetencia cervical (abortos repetidos de segundo trimestre secundarios a dilatación cervical pasiva), se beneficiarían del cerclaje cervical en forma electiva entre las 12-14 semanas. Sin embargo, la evidencia no es concluyente respecto de cuál es la mejor opción terapéutica para las pacientes sin historia característica, pero en riesgo de incompetencia cervical (acortamiento cervical ecográfico o antecedente de parto prematuro). Se requiere de estudios randomizados de buen diseño para resolver la pregunta en cada grupo Abstract in english Cervical Incompetence is characterized by progressive cervical dilation in the absence of uterine contractions, leading to second trimester abortion and preterm birth. Cerclage has been used for Cervical Incompetence however its efficacy has not been confirmed. The best evidence and clinical judge s [...] uggest that those patients with classical history of cervical incompetence (recurrent painless dilation and spontaneous midtrimester abortion) will benefit of elective cerclage at 12-14 weeks. However, the evidence is not conclusive for patients with no history, but at risk of cervical incompetence (cervical shortening evidenced by ultrasound or antecedents of preterm birth). Randomized trials are needed to answer this question for each group

Víctor, Miranda H; Jorge A, Carvajal C.

316

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... and fall into the uterine cavity, in which case we would refer you back to your gynecologist for a D&C. Once this procedure is done, we feel it's very important, we will follow you when we do these ...

317

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... see in women with uterine fibroids is heavy bleeding. In fact, some of our patients have such heavy bleeding that they have to stay home from work ... the size that it was. And all the bleeding that that fibroid caused now is it basically ...

318

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... 1,000 uterine fibroid embolizations. Fibroids are common, benign tumors in women. They can range in size from ... they're not causing a problem. These are benign tumors. They're non-cancerous tumors. So if you ...

319

Uterine Fibroid Embolization  

Medline Plus

Full Text Available ... And you can see that each of these lesions here, these are fibroids, these round balls. And ... may break off and fall into the uterine cavity, in which case we would refer ... she'll be home taking oral mediations to control her cramping. And within a ...

320

Cervical radiculopathy.  

Science.gov (United States)

Cervical radiculopathy is a condition encountered commonly in the evaluation of neck pain that may result in significant discomfort and functional deficits. Although the long-term prognosis of this condition is favorable, a standardized approach to therapy is important to minimize unnecessary tests and identify patients who require more urgent intervention. Patient education, pain control, and physical therapy are the first line of therapy. Patients who have protracted pain or significant functional deficits may require a more thorough evaluation, including imaging, electrodiagnostic testing, and, possibly, surgical referral. This article outlines the basic clinical, diagnostic, and therapy considerations in the evaluation of cervical radiculopathy. PMID:17445734

Polston, David W

2007-05-01

321

Tumor-associated macrophages induce lymphangiogenesis in cervical cancer via interaction with tumor cells.  

Science.gov (United States)

Our studies were conducted to investigate the clinical and functional significance of tumor-associated macrophages (TAMs) in cervical tumor lymphatic metastasis. We found that the increase in macrophages in tumor stroma is significantly associated with lymphatic metastasis (p = 0.017), through performing immunohistochemical staining in 111 cervical samples (55 invasive squamous carcinomas of uterine cervix, 27 cervical intraepithelial neoplasms III, and 29 normal cervix). The human lymphatic endothelial cells (HLEC), which were cultured in conditioned medium of cervical cancer cell-macrophage coculture, formed more tube-like structures in vitro, when compared with those in conditioned mediums of LEC, normal cervical epithelium, single macrophage, and single cervical cancer cell (all p promote lymphangiogenesis mainly through interaction with surrounding cervical cancer cells. PMID:24698523

Ding, Hui; Cai, Jing; Mao, Min; Fang, Yan; Huang, Zaiju; Jia, Jinghui; Li, Tao; Xu, Linjuan; Wang, Junjie; Zhou, Jun; Yang, Qiang; Wang, Zehua

2014-11-01

322

Radiologic diagnosis and treatment of iatrogenic acquired uterine arteriovenous malformation  

Energy Technology Data Exchange (ETDEWEB)

To analyze gray-scale US, color and duplex Doppler US, and angiographic findings in patients with acquired uterine arteriovenous malformations (AVMs), and to evaluate the usefulness of these modalities in the diagnosis of this disease and the effect of transcatheter arterial embolization in its treatment. During a recent seven-year period, we diagnosed 21 cases of acquired uterine AVM. Nineteen of these patients had a history of causative D and C (between one and seven D and C procedures per patient), one had a history of causative cesarean section, and one had cervical conization. All patients underwent transabdominal and endovaginal gray-scale, color Doppler, and duplex Doppler US and angiography, with therapeutic embolization of bilateral uterine arteries. The majority underwent follow-up Doppler US after embolization. The gray-scale US morphology of uterine AVMs included subtle myometrial inhomogeneity and multiple distinct, small anechoic spaces in the thickened myometrium or endometrium. Color Doppler US showed a tangle of tortuous vessels with multidirectional, high-velocity arterial flow, which was focally or asymmetrically distributed. Duplex Doppler US depicted a waveform of fast arterial flow with low resistance, while angiography demonstrated a complex tangle of vessels supplied by enlarged uterine arteries, in association with early venous drainage during the arterial phase, and staiss of contrast medium within abnormal vasculature. Where AVMs were combined with a pseudoaneurysm, this finding was observed. Transcatheter arterial embolization provided a complete cure, without recurrence. Color and duplex Doppler US in an appropriate modality for the detection and diagnosis of uterine AVMs and for follow-up after embolization. Transcatheter arterial embolization is a safe and effective method of treating this disease.

Kwon, Jung Hyeok [College of Medicine, Keimyung Univ., Taegu (Korea, Republic of)

2002-05-01

323

Radiologic diagnosis and treatment of iatrogenic acquired uterine arteriovenous malformation  

International Nuclear Information System (INIS)

To analyze gray-scale US, color and duplex Doppler US, and angiographic findings in patients with acquired uterine arteriovenous malformations (AVMs), and to evaluate the usefulness of these modalities in the diagnosis of this disease and the effect of transcatheter arterial embolization in its treatment. During a recent seven-year period, we diagnosed 21 cases of acquired uterine AVM. Nineteen of these patients had a history of causative D and C (between one and seven D and C procedures per patient), one had a history of causative cesarean section, and one had cervical conization. All patients underwent transabdominal and endovaginal gray-scale, color Doppler, and duplex Doppler US and angiography, with therapeutic embolization of bilateral uterine arteries. The majority underwent follow-up Doppler US after embolization. The gray-scale US morphology of uterine AVMs included subtle myometrial inhomogeneity and multiple distinct, small anechoic spaces in the thickened myometrium or endometrium. Color Doppler US showed a tangle of tortuous vessels with multidirectional, high-velocity arterial flow, which was focally or asymmetrically distributed. Duplex Doppler US depicted a waveform of fast arterial flow with low resistance, while angiography demonstrated a complex tangle of vessels supplied by enlarged uterine arteries, in association with early venous drainage during the arterial phase, and staiss of contrast medium within abnormal vasculature. Where AVMs were combinnormal vasculature. Where AVMs were combined with a pseudoaneurysm, this finding was observed. Transcatheter arterial embolization provided a complete cure, without recurrence. Color and duplex Doppler US in an appropriate modality for the detection and diagnosis of uterine AVMs and for follow-up after embolization. Transcatheter arterial embolization is a safe and effective method of treating this disease

324

Molecular detection of human papillomavirus in 594 uterine cervix samples from moroccan women, 147 biopsies and 447 swabs  

OpenAIRE

Uterine cervix cancer is the second most frequent female cancer after breast cancer in Morocco and represents a public health problem. Cervical cancer is highly linked to human papillomavirus (HPV) especially types 16 and 18 which are the highly oncogenic genotypes. To identify the contribution of HPV testing in the prevention of cervical cancer in Morocco, 147 biopsies collected at the Institut National d’Oncologie and 447 swabs from pathology laboratories and gynaecologist off...

Amrani, M.; Lalaoui, K.; El Mzibri, M.; Lazo, Pedro A.; Belabbas, M. A.

2003-01-01

325

Splenic Metastasis of Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature  

OpenAIRE

Metastasis from various neoplasms to the spleen is very rare and most of the cases are found at autopsy. We report a patient presenting with uterine cervical cancer with splenic metastases. A 49-year-old woman presenting with genital bleeding was referred to our hospital and diagnosed with stage IIB cervical cancer. She underwent concomitant chemoradiotherapy (CCRT) consisting of 50?Gy whole pelvis irradiation, high-dose-rate intracavitary brachytherapy 24?Gy/4 fractions and six weeks of ...

Shigeki Taga; Mari Sawada; Aya Nagai; Dan Yamamoto; Ryoji Hayase

2014-01-01

326

Staging of carcinoma of the uterine cervix and endometrium  

Energy Technology Data Exchange (ETDEWEB)

Carcinoma of the uterine cervix and endometrium are common gynecologic malignancies. Both carcinomas are staged and managed by means of the International Federation of Gynecology and Obstetrics (FIGO) staging system. In uterine cervical cancer, the FIGO staging system is determined preoperatively by limited conventional procedures. Although this system is effective for early stage disease, it has inherent inaccuracies in advanced stage diseases and does not address nodal involvement. CT and MR imaging are widely used as comprehensive imaging modalities to evaluate tumor size and extent, and nodal involvement. MR imaging is an excellent modality for depicting invasive cervical carcinoma and can provide objective measurement of tumor volume, and provides high negative predictive value for parametrial invasion and stage IVA disease. In contrast, endometrial cancer is surgically staged. Beside recognition of the important prognostic factors, including histologic subtype and grade, accurate assessment of the tumor extent on preoperative MR imaging is expected to greatly optimize surgical procedure and therapeutic strategy. Contrast-enhanced MR imaging can offer ''one stop'' examination for evaluating the depth of myometrial invasion cervical invasion and nodal metastases. Evaluation of myometrial invasion on MR imaging may be an alternative to gross inspection of the uterus during the surgery. (orig.)

Koyama, Takashi; Tamai, Ken; Togashi, Kaori [Kyoto University, Department of Diagnostic Radiology, Graduate School of Medicine, Kyoto (Japan)

2007-08-15

327

Low-cost technology for screening uterine cervical cancer / Technique peu coûteuse de dépistage du cancer du col utérin / Tecnología de bajo costo para el cribado del cáncer cervicouterino  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: English Abstract in spanish El cáncer cervicouterino es el tumor maligno más frecuente entre las mujeres de la India. En los países en desarrollo no es posible emprender programas de cribado citológico de ámbito nacional debido a la escasez de personal adiestrado y a la falta de la infraestructura necesaria. La simple inspecci [...] ón visual del cuello uterino detecta los cánceres tempranos con una menor sensibilidad y especificidad que los estudios citológicos. En nuestros estudios anteriores hallamos una tasa de detección relativamente baja de las lesiones cervicouterinas precancerosas. A raíz de ello desarrollamos el Magnivisualizador, un dispositivo de iluminación y aumento cuyo precio es de Rs 1500 (US$ 36). Pretendíamos así mejorar la sensibilidad de la inspección visual simple en la detección de lesiones precancerosas o indicativas de cáncer temprano.De fácil manejo, este instrumento portátil funciona con una pila recargable de 12 V. Consiste en una cámara de luz con un reflector en un lado y un condensador en el otro, equipada con una bombilla halógena de 12 V y 50 W. La cámara tiene en la parte superior, en el extremo del condensador, un cristal de aumento de 2,5 dioptrías y 100 mm de diámetro. Los resultados de la inspección visual simple realizada mediante el Magnivisualizador fueron comparados con los de la colposcopia y/o los informes histológicos en una muestra de 402 mujeres. En total se diagnosticaron histológicamente 73 displasias leves, 76 displasias avanzadas y 59 carcinomas in situ o cánceres invasivos en sus primeras fases. En el caso de las displasias leves, la sensibilidad del análisis citológico fue del 75,3%, y la del Magnivisualizador, del 57,5%. En lo que atañe a las displasias graves y los carcinomas in situ o los cánceres invasivos tempranos, en cambio, la sensibilidad fue del 94,9% con los dos métodos. La tasa de falsos positivos fue del 1,0% en los estudios citológicos, frente al 5,7% con el Magnivisualizador. La especificidad del cribado alcanzó el 94,3% con este último, y el 99% en el análisis citológico.El Magnivisualizador aumentó considerablemente la sensibilidad conseguida mediante la inspección visual simple, no sólo en la detección de carcinomas in situ o de cánceres invasivos tempranos, sino también en el caso de las lesiones precancerosas. Su sensibilidad en la detección de las displasias avanzadas y las lesiones más graves precitadas fue comparable a la del análisis citológico, y disminuyó la tasa de falsos positivos. Además, el costo del examen con Magnivisualizador fue de US$ 0,55, mientras que el del análisis citológico fue de US$ 1,10. La sencilla inspección visual que permite el dispositivo puede realizarse incluso en un centro de atención primaria, sin más requisito que una mesa de exploración Abstract in english We report on an illuminated, low-cost (Rs 1500 (US$ 36)) magnifying device (Magnivisualizer) for detecting precancerous lesions of the uterine cervix. A total of 403 women attending a maternal and child health care clinic who had abnormal vaginal discharge and related symptoms were referred for deta [...] iled pelvic examination and visual inspection by means of the device after the application of 5% (v/v) acetic acid. Pap smears were obtained at the same time. The results were compared with those obtained using colposcopy and/or histology. The Magnivisualizer improved the detection rate of early cancerous lesions from 60%, for unaided visual inspection, to 95%. It also permitted detection of 58% of cases of low-grade dysplasia and 83% of cases of high-grade dysplasia; none of these cases were detectable by unaided visual inspection. For low-grade dysplasia the sensitivity of detection by means of the Magnivisualizer was 57.5%, in contrast with 75.3% for cytological examination. However, the two methodologies had similar sensitivities for higher grades of lesions. The specificity of screening with the Magnivisualizer was 94.3%, while that of cytology was 99%

Aditya, Parashari; Veena, Singh; Ashok, Sehgal; Labani, Satyanarayana; Pushpa, Sodhani; Madan M., Gupta.

2000-08-01

328

UTERINE ARTERY EMBOLIZATION FOR THE TREATMENT OF UTERINE FIBROIDS  

OpenAIRE

AIM: To determine the outcome of uterine artery embolization in patients with symptomatic uterine fibroids, in order to assess the response of symptoms and fibroid size. METHODS: We analyzed the results of a population study of 112 patients with uterine fibroids made in the period between 2006 and 2010. Main parameters were assessed improvement or disappearance of symptoms and downsizing the adverse effects of the procedure. RESULTS: The predominant age of the patients are in ...

González- Perez Santiago; Beltrán Vaquero David; Rodri?guez Martin, Mari?a La O.; García Valle Silvia; Perez Escanilla Jose Luis; Doyague Sánchez María José; García Alonso Jesús; Velasco Pelayo Luis; Basabe Picaso Josefina

2013-01-01

329

Coprates Erosion  

Science.gov (United States)

4 June 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows layered, light-toned, sedimentary rocks that have been exposed by erosion in Coprates Chasma, one of the many chasms which comprise the Valles Marineris trough system on Mars. Location near: 13.1oS, 65.0oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Autumn

2006-01-01

330

Should helical tomotherapy replace brachytherapy for cervical cancer? Case report  

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Full Text Available Abstract Background Stereotactic body radiation therapy (SBRT administered via a helical tomotherapy (HT system is an effective modality for treating lung cancer and metastatic liver tumors. Whether SBRT delivered via HT is a feasible alternative to brachytherapy in treatment of locally advanced cervical cancer in patients with unusual anatomic configurations of the uterus has never been studied. Case Presentation A 46-year-old woman presented with an 8-month history of abnormal vaginal bleeding. Biopsy revealed squamous cell carcinoma of the cervix. Magnetic resonance imaging (MRI showed a cervical tumor with direct invasion of the right parametrium, bilateral hydronephrosis, and multiple uterine myomas. International Federation of Gynecology and Obstetrics (FIGO stage IIIB cervical cancer was diagnosed. Concurrent chemoradiation therapy (CCRT followed by SBRT delivered via HT was administered instead of brachytherapy because of the presence of multiple uterine myomas with bleeding tendency. Total abdominal hysterectomy was performed after 6 weeks of treatment because of the presence of multiple uterine myomas. Neither pelvic MRI nor results of histopathologic examination at X-month follow-up showed evidence of tumor recurrence. Only grade 1 nausea and vomiting during treatment were noted. Lower gastrointestinal bleeding was noted at 14-month follow-up. No fistula formation and no evidence of haematological, gastrointestinal or genitourinary toxicities were noted on the most recent follow-up. Conclusions CCRT followed by SBRT appears to be an effective and safe modality for treatment of cervical cancer. Larger-scale studies are warranted.

Chen Yu-Jen

2010-11-01

331

Educação em saúde para prevenção do câncer de colo do útero em mulheres do município de Santo Ângelo/RS Education in health for prevention of uterine cervical cancer in women in Santo Ângelo, state of Rio Grande do Sul, Brazil  

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Full Text Available No Brasil, o câncer cérvico-uterino constitui importante problema de saúde, pois apresenta alto índice de letalidade entre mulheres de varias idades. O exame citopatológico foi preconizado como medida de prevenção deste tipo de câncer, devendo ser realizado a partir do início da vida sexual. O estudo teve um caráter prático de promover educação em saúde sexual e conhecer o perfil da saúde sexual de mulheres de Santo Ângelo/RS. As palestras abordaram formas de prevenção e identificação de possíveis sintomas da doença. O levantamento do perfil de saúde sexual das participantes foi realizado através da aplicação de um questionário estruturado. Participaram das palestras 140 mulheres com idades entre 15 e 60 anos. Verificou-se que, mesmo enfrentando dificuldades e medo, a maioria delas realiza exame preventivo, motivada por aparecimento de sintomas e pelo hábito de cuidar da saúde. As participantes referiram a importância da integração entre profissionais e educadores em Saúde. O estudo foi direcionado no sentido de dar relevância à promoção da saúde e à prevenção do câncer, buscando evitar a doença e obter melhores condições de vida para as mulheres.In Brazil, cervical uterine cancer is a major public health problem as it has high mortality rate indices among women of different ages. A cytopathological examination is recommended for preventing this type of cancer from the early stages of a woman's reproductive life. The scope of this study was both to give talks on sexual health education and establish the sexual health profile of women from St. Angelo/RS. The lectures included measures for prevention as well as identification of possible symptoms of the disease. The research into the sexual health profile of the participants was conducted by a structured questionnaire applied to 140 women aged between 15 and 60. It was found that even experiencing difficulties and apprehension, the majority of the women performed the preventive examination. The motivation for taking the exam is the appearance of symptoms and the habit of caring for their health. The participants mentioned the importance of health professionals and educators working together. The study sought to promote health and cancer prevention, seeking to avoid the disease and ensure better living conditions for women.

Micheli Renata Casarin

2011-09-01

332

The role of p53 inactivation in human cervical cell carcinoma development.  

OpenAIRE

We investigated the association between human papillomavirus (HPV) infection and p53 gene mutation in 47 primary uterine cervical cancers. HPV DNA sequences were present in 43 cancers (91.5%), and one of these cancers contained a p53 gene mutation. In addition, one of the remaining four HPV-negative cancers also contained a p53 gene mutation. As a result, p53 inactivation corresponded to the development of 44 of the primary uterine cervical cancers studied (93.6%). We obtained both primary an...

Miwa, K.; Miyamoto, S.; Kato, H.; Imamura, T.; Nishida, M.; Yoshikawa, Y.; Nagata, Y.; Wake, N.

1995-01-01

333

Detection of Human Papillomavirus in Chronic Cervicitis, Cervical Adenocarcinoma, Intraepithelial Neoplasia and Squamus Cell Carcinoma  

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Full Text Available Background: Cervical cancer is the second most common cancer in women worldwide. Recent studies show that human papillomavirus (HPV DNA is present in all cervical carcinomas and in some cervicitis cases, with some geographical variation in viral subtypes. Therefore determination of the presence of HPV in the general population of each region can help reveal the role of these viruses in tumors. Objectives: This study aimed to estimate the frequency of infection with HPV in cervicitis, cervical adenocarcinoma, intraepithelial neoplasia and squamus cell carcinoma samples from the Isfahan Province, Iran. Patients and Methods: One hundred and twenty two formalin fixed paraffin embedded tissue samples of crevicitis cases and different cervix tumors including cervical intraepithelial neoplasia (CIN (I, II, III, squamus cell carcinoma (SCC and adenocarcinoma were collected from histopathological files of Al-Zahra Hospital in Isfahan. Data about histopathological changes were collected by reexamination of the hematoxylin and eosin stained sections. DNA was extracted and subjected to Nested PCR using consensus primers, MY09/MY11 and GP5+/GP6+, designed for amplification of a conserved region of the genome coding for L1 protein. Results: In total 74.5% of the tested samples were positive for HPV. Amongst the tested tumors 8 out of 20 (40% of CIN (I, II, III, 5 out of 21 (23.8% of adenocarcinoma cases and 78 out of 79 chronic cervicitis cases were positive for HPV. Conclusions: The rate of different carcinomas and also the rate of HPV infection in each case were lower than other reports from different countries. This could be correlated with the social behavior of women in the area, where they mostly have only one partner throughout their life, and also the rate of smoking behavior of women in the studied population. On the other hand the rate of HPV infection in chronic cervicitis cases was much higher than cases reported by previous studies. This necessitates more attention to the role of human papillomaviruses in the their induction in the studied area. Keywords: Polymerase Chain Reaction; Uterine Cervical Neoplasms; Uterine Cervicitis

Elahe Mirzaie-Kashani

2014-05-01

334

Uterine Inversion; A case report  

OpenAIRE

The puerperal uterine inversion is a rare and severe complication occurring in the third stage of labour. The mechanisms are not completely known. However, extrinsic factors such as oxytocic arrests after a prolonged labour, umbilical cord traction or abdominal expression are pointed. Other intrinsic factors such as primiparity, uterine hypotonia, various placental localizations, fundic myoma or short umbilical cord were also reported. The diagnosis of the uterine inversion is mainly supporte...

Bouchikhi, C.; Saadi, H.; Fakhir, B.; Chaara, H.; Bouguern, H.; Banani, A.; Melhouf, Ma

2008-01-01

335

Phenotypic modulation of fibroblastic cells in the mucous layer of the human uterine cervix at term.  

Science.gov (United States)

The uterine cervix is a dynamic structure with a high capacity to adapt to different, even opposing, roles during the sequence of physiological events of gestation (for example, acting as a barrier to retain the fetus during pregnancy and dilating to allow delivery at term). Histoarchitectural changes of the uterine cervix allow its successful adaptation. The aim of this study was to investigate whether fibroblastic cell plasticity, described in the lamina propria of the rat uterine cervix at term, could be observed in women too. Biopsy specimens of non-pregnant and intrapartum human cervices were studied under the transmission electron microscope, and cytoskeletal differentiation markers were identified by immunohistochemistry under the light microscope. Desmin-positive cells were present in the mucous layer of the cervix during labour. These cells displayed cytoplasmic processes (typical of myofibroblasts) that also stained positively for vimentin. The main ultrastructural features for defining the myofibroblast under the electron microscope were also observed in these cells. However, cervices of non-pregnant women contained resident fibroblasts at the same location. Examination of the differentiation repertoire of fibroblastic cells in the mucous layer of the uterine cervix resulted in the characterization of myofibroblasts at term. The implications of the plasticity of fibroblastic-myofibroblastic cells in the physiological changes displayed in the uterine cervix during pregnancy, labour and postpartum involution require further investigation. PMID:12530916

Montes, G S; Zugaib, M; Joazeiro, P P; Varayoud, J; Ramos, J G; Muñoz-de-Toro, M; Luque, E H

2002-12-01

336

Uterine fibroid embolization  

International Nuclear Information System (INIS)

Full text: Introduction: Today, after numerous lengthy randomized trials embolization of uterine fibroids has become a standard treatment. Percutaneous embolization of myomas is a micro - invasive surgery, which can be regarded as an alternative to traditional surgery. Although these data 2/3 of the patients were not informed about this treatment option. What you will learn: The uterine embolization is minimal invasive non-surgical procedure. It is an alternative treatment to surgery. Under local anesthesia in the femoral artery puncture reaches the internal iliac artery and uterine arteries. Reached selectively by the catheter and chemicals, which causes clogging, are injected into them. In the vessels that feed fibroids occur a process like an attack, the feeding stops, it starts to shrink and it is replaced by fibrous tissue. The blood vessels of the healthy tissue are different in size and have a plurality of collateral connections as opposed to those of the myoma and thus the blood supply to the normal tissue of the uterus is not distorted. Discussion: Nowadays there are more well- calibrated materials for embolization and those with a particle size of about 700µ are proven as the most successful. The procedure is well tolerated, but after a pain occurs, which has to be covered with anesthetics. Usually pain and metrorrhagia disappear immediately. The fibroids themselves shrink to varying degrees. Hospital stay was significantly shorter than that after surgery, and remained fertile power. Complications are few and rare require further treatment. Multiple nodes are problematic and it is difficult to detect the primary one. A three and six months tracking by MRI is desirable. Conclusion: Embolization of uterine myoma is an established method of treatment primarily on clinical symptoms resulting therefrom. In all patients rapidly disappear metrorrhagia symptoms and morbidity, the volume of the assembly decrease, which together with shorter hospital stays and fertility preservation is well accepted by patients and therefore it is a good alternative to surgery

337

Uterine fibroids: current perspectives  

OpenAIRE

Aamir T Khan,1 Manjeet Shehmar,1 Janesh K Gupta21Birmingham Women's Hospital, Edgbaston, Birmingham, UK; 2Academic Department of Obstetrics and Gynaecology, University of Birmingham, Birmingham, UKAbstract: Uterine fibroids are a major cause of morbidity in women of a reproductive age (and sometimes even after menopause). There are several factors that are attributed to underlie the development and incidence of these common tumors, but this further corroborates their relatively unkno...

At, Khan; Shehmar M; Jk, Gupta

2014-01-01

338

Management of Uterine Sarcomas  

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Full Text Available Uterine sarcomas are rare malignant tumors characterized by a great clinical and histopathological diversity. The aim of this work is to analyze the difficulties of diagnosis, therapeutic and prognosis posed by these tumors. Thirty-seven patients with uterine sarcoma, collected in the service Radiotherapy and Oncology, University Ibn Rochd of Casablanca between January 2000 and December 2007 were included in this study retrospective. The average patient age was 50 years (17-76. The bleeding was present in all patients, isolated in 54% of cases associated with pelvic pain in 24.6% and a mass abdomino-pelvic in seven patients. The average time of evolution was 10 months. The main histological type was found leiomyosarcoma. Twenty four patients in our series underwent total hysterectomy without annexial conservation. The surgery R0 was obtained in 43% of cases. The sarcomas were classified as stage IV in 51.4%. Adjuvant radiotherapy was indicated in 13 patients. After a mean of 20 months, half of patients evaluable presented a local relapse and/or metastatic, the third of cases were tumor progression while complete remission was maintained in 18.5% of cases. Uterine sarcomas are rare malignant mesenchymal tumor, which often occur in women after menopause. The main prognostic factors are hormonal status of the patient, stage clinical, histological type, histological grade and quality surgical excision. The management of uterine sarcomas is multidisciplinary, based mainly on surgery remains the only means of cure. Adjuvant radiotherapy allows decreased risk of local recurrence, with no impact on survival achieved at best 30% at 5 years. The role of chemotherapy remains confirm.

Asmaa Naim

2012-10-01

339

Cervical Cancer Stage IIIA  

Science.gov (United States)

... My Pictures Browse Search Quick Search Image Details Cervical Cancer Stage IIIA View/Download: Small: 612x612 View Download Add to My Pictures Title: Cervical Cancer Stage IIIA Description: Stage IIIA cervical cancer; drawing ...

340

Cervical spine CT scan  

Science.gov (United States)

... scan – cervical spine; Computed tomography scan – cervical spine; CT scan - cervical spine; Neck CT scan ... Risks of CT scans include: Being exposed to radiation Allergic reaction to contrast dye CT scans expose you to more radiation than ...

341

Cervical Collagen Concentration within Fifteen Months after Delivery  

DEFF Research Database (Denmark)

OBJECTIVE: Cervical collagen concentration decreases during pregnancy. The increased risk of preterm birth following a short interpregnancy interval may be explained by an incomplete remodeling of the cervix. The objective of this study was to describe the changes in cervical collagen concentration over 15 months following delivery. METHODS: The collagen concentrations were determined in cervical biopsies obtained from 15 women at 3, 6, 9, 12, and 15 months after delivery. RESULTS: The mean cervical collagen concentrations were 50, 59, 63, 65, and 65 % of dry weight (SD 4.2 – 6.5). This increase was statistically significant until month 9, but not between months 9 and 12. CONCLUSIONS: Low collagen concentrations in the uterine cervix may contribute to the association between a short interpregnancy interval and preterm birth.

Sundtoft, Iben; Uldbjerg, Niels

2011-01-01

342

Rheumatoid arthritis of the cervical spine.  

Science.gov (United States)

The cervical spine is commonly affected in patients with rheumatoid arthritis. Erosive synovitis of the joints of the cervical spine can result in various types of subluxations. Subluxations and pannus formation can cause significant pain and neurological compromise. Surgery is an important treatment modality for patients with intractable neck pain and neurological deficits. This article reviews the indications for surgery and surgical procedures of decompression and arthrodesis. New surgical fixation techniques have resulted in improved arthrodesis rates. However, long-term effects on adjacent motion segments is not known. The cornerstone of good surgical outcome remains careful selection of patients and appropriate choice of surgical decompression and fusion. PMID:12524563

Kolen, E Robert; Schmidt, Meic H

2002-06-01

343

Surgical uterine drainage and lavage as treatment for canine pyometra  

Scientific Electronic Library Online (English)

Full Text Available Pyometra is a common post-oestral syndrome in bitches. Classical treatment consists of either ovariohystorectomy or medical intervention. Surgical uterine drainage and lavage via direct trans-cervical catheterisation using a 5 % povidone-iodine in saline solution was performed successfully in 8 bitc [...] hes with pyometra. All bitches conceived and whelped without complications subsequent to this treatment. It is concluded that this method offers an effective alternative treatment for canine pyometra with shorter recovery times as well as good clinical recovery and pregnancy rates in bitches destined for further breeding.

K G M, De Cramer.

2010-09-01

344

Characterization of the global profile of genes expressed in cervical epithelium by Serial Analysis of Gene Expression (SAGE  

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Full Text Available Abstract Background Serial Analysis of Gene Expression (SAGE is a new technique that allows a detailed and profound quantitative and qualitative knowledge of gene expression profile, without previous knowledge of sequence of analyzed genes. We carried out a modification of SAGE methodology (microSAGE, useful for the analysis of limited quantities of tissue samples, on normal human cervical tissue obtained from a donor without histopathological lesions. Cervical epithelium is constituted mainly by cervical keratinocytes which are the targets of human papilloma virus (HPV, where persistent HPV infection of cervical epithelium is associated with an increase risk for developing cervical carcinomas (CC. Results We report here a transcriptome analysis of cervical tissue by SAGE, derived from 30,418 sequenced tags that provide a wealth of information about the gene products involved in normal cervical epithelium physiology, as well as genes not previously found in uterine cervix tissue involved in the process of epidermal differentiation. Conclusion This first comprehensive and profound analysis of uterine cervix transcriptome, should be useful for the identification of genes involved in normal cervix uterine function, and candidate genes associated with cervical carcinoma.

Piña-Sanchez Patricia

2005-09-01

345

Uterine rupture after the uterine fundal pressure maneuver.  

Science.gov (United States)

Abstract Objective: To clarify the incidence of uterine fundal pressure at delivery and its effect on uterine rupture. Study design: A questionnaire was sent to 2518 institutions in Japan. We received a response from 1430. Results: Of reporting institutions, 89.4% used fundal pressure in at least some of their deliveries. Among the 347,771 women who delivered vaginally in this study, 38,973 (11.2%) were delivered with the assistance of fundal pressure. There were six cases of uterine rupture associated with uterine fundal pressure, with one case resulting in maternal death secondary to amniotic fluid embolism. Conclusion: Since uterine fundal pressure may potentially cause serious injury to either the mother and/or neonates, the indications for application need to be clearly elucidated, and obstetric care providers also need comprehensive education and training. PMID:25389983

Hasegawa, Junichi; Sekizawa, Akihiko; Ishiwata, Isamu; Ikeda, Tomoaki; Kinoshita, Katsuyuki

2014-11-01

346

Effects of the preoperative irradiation using small sourses for cervical cancer  

International Nuclear Information System (INIS)

Twenty four cases of cervical cancer received preoperative irradiation of a total of either 3,000 mgh, 4,500 mgh, and 6,000 mgh using small sourses. Large sections of the excected uterine, were prepared and isodose curves in the neighbourhood of the sourse were drown using glass dosimeter and water phantom. These lines were superimposed on large sections thereby, cervical tissue was examined histopathologically by various stages of absorbed dose. (Mukohata, S.)

347

Cerebral metastasis of cervical cancer, report of two cases and review of the literature  

OpenAIRE

Cervical cancers spread locally through the angiolymphatic apparatus and very rarely metastasize to the brain. The intracranial metastasis is a late event and a sign of poor prognosis. We present two cases of uterine cervical carcinomas with brain metastasis presenting with severe headaches in one case and hemiparesis and aphasia in the other one. Palliative craniotomy and debulking of the tumor was performed in both patients.

Setoodeh, Reza; Hakam, Ardeshir; Shan, Yuan

2012-01-01

348

Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine?  

OpenAIRE

Human papillomavirus (HPV) infection is the cause of squamous cell carcinoma of the uterine cervix. This causative relationship has provided the rationale and incentive for development of a prophylactic vaccine. Such a vaccine, if found to be effective, could reduce the need for cervical cancer screening and have a profound effect on the incidence of cervical and other anogenital cancers. This review begins by examining the basic biological and epidemiological principles relevant to the devel...

Dillner, Joakim; Brown, Darron R.

2004-01-01

349

Cervical intraepithelial neoplasia in patients with breast cancer: a cytological and colposcopic study.  

OpenAIRE

Twenty-six patients with treated breast cancer who had been randomised previously to receive combination chemotherapy including alkylating agents (n = 14) or to undergo oophorectomy (n = 12) following surgery underwent cytological and colposcopic screening of the uterine cervix. Colposcopically directed cervical punch biopsies were taken from all patients in whom a colposcopic abnormality was detected. Breast cancer patients were compared with 79 controls with normal cervical cytology and no ...

Hughes, R. G.; Colquhoun, M.; Alloub, M.; Chetty, U.; Smart, G. E.

1993-01-01

350

Risk Factors in a Sample of Patients with Advanced Cervical Cancer  

OpenAIRE

The estimated burden of neoplasia of uterine cervix in the 27 EU member states sums up to 34300 cases and 16200 death, with higher incidence and mortality in eastern countries. A number of risk factors increase the likelihood of developing cervical cancer. Even if the risk factors significantly increase the chances of developing cervical cancer, a large number of women with risk factors do not develop the disease, and when a woman develops cancer or precancerous lesions in the cervix may be d...

Irimie, Sorina; Vlad, Mariana; Mirestean, Ileana Maria; Balacescu, Ovidiu; Rus, Meda; Balacescu, Loredana; Berindan-neagoe, Ioana; Buiga, Rares?; Ordeanu, Claudia; Nagy, Viorica; Irimie, Alexandru

2011-01-01

351

MRI staging of endometrial and cervical carcinoma  

International Nuclear Information System (INIS)

Magnetic resonance imaging (MRI) has proven to be a suitable imaging modality for the evaluation of uterine neoplasms. In contrast to computed tomography and ultrasound, MRI allows multiplanar observer-independent imaging of the whole female pelvis with high tissue-specific contrast. This article reviews the advantages and limitations of MRI in the staging of endometrial and cervical carcinoma, focusing on MRI with reference to other imaging modalities. New technical developments are discussed and an imaging approach for these tumor types is suggested. (orig.)

352

Malignant transformation of uterine leiomyoma  

OpenAIRE

A rare case of malignant transformation of uterine leiomyoma is reported. A 54 year old lady, nulliparous and 2 years postmenopausal presented to gynecology clinic with a pelvi – abdominal mass and ultrasound scan suggestive of multiple uterine fibroid. Total abdominal hysterectomy performed. Histopathology report showed leiomyosarcomative changes from benign leiomyoma within the huge mass.

Al Ansari, Afaf A.; Al Hail, Fatima A.; Abboud, Emad

2013-01-01

353

Cervical Laminoplasty for Multilevel Cervical Myelopathy  

Science.gov (United States)

Cervical spondylotic myelopathy can result from degenerative cervical spondylosis, herniated disk material, osteophytes, redundant ligamentum flavum, or ossification of the posterior longitudinal ligament. Surgical intervention for multi-level myelopathy aims to decompress the spinal cord and maintain stability of the cervical spine. Laminoplasty was major surgical advancement as laminectomy resulted in kyphosis and unsatisfactory outcomes. Hirabayashi popularised the expansive open door laminoplasty which was later modified several surgeons. Laminoplasty has changed the way surgeons approach multilevel cervical spondylotic myelopathy. PMID:21991408

Sayana, Murali Krishna; Jamil, Hassan; Poynton, Ashley

2011-01-01

354

Uterine Inversion; A case report  

Science.gov (United States)

The puerperal uterine inversion is a rare and severe complication occurring in the third stage of labour. The mechanisms are not completely known. However, extrinsic factors such as oxytocic arrests after a prolonged labour, umbilical cord traction or abdominal expression are pointed. Other intrinsic factors such as primiparity, uterine hypotonia, various placental localizations, fundic myoma or short umbilical cord were also reported. The diagnosis of the uterine inversion is mainly supported by clinical symptoms. It is based on three elements: haemorrhage, shock and a strong pelvic pain. The immediate treatment of the uterine inversion is required. It is based on a medical reanimation associated with firstly a manual reduction then surgical treatment using various techniques. We report an observation of a 25 years old grand multiparous patient with a subacute uterine inversion after delivery at home. PMID:21516244

Bouchikhi, C; Saadi, H; Fakhir, B; Chaara, H; Bouguern, H; Banani, A; Melhouf, MA

2008-01-01

355

Cervical Laminoplasty for Multilevel Cervical Myelopathy  

OpenAIRE

Cervical spondylotic myelopathy can result from degenerative cervical spondylosis, herniated disk material, osteophytes, redundant ligamentum flavum, or ossification of the posterior longitudinal ligament. Surgical intervention for multi-level myelopathy aims to decompress the spinal cord and maintain stability of the cervical spine. Laminoplasty was major surgical advancement as laminectomy resulted in kyphosis and unsatisfactory outcomes. Hirabayashi popularised the expansive open door lami...

Murali Krishna Sayana; Hassan Jamil; Ashley Poynton

2011-01-01

356

Cervical spine complications in rheumatoid arthritis patients. Awareness is the key to averting serious consequences.  

Science.gov (United States)

Rheumatoid arthritis is associated with several pathologic changes in the cervical spine, including loss of articular cartilage, ligamentous destruction, and bone erosion. These changes may lead to one or a combination of complications, including atlantoaxial subluxation, cranial settling, subaxial cervical subluxation, and periodontoid pannus formation. Surgical management of these problems should focus on relieving pain, stabilizing the spine, and decompressing neural elements. PMID:10649674

Alberstone, C D; Benzel, E C

2000-01-01

357

Erosion Control Measures  

Science.gov (United States)

This lesson will discuss erosion control practices in the agricultural and construction environments. The impact of erosion management practices will be demonstrated with exercises using a USLE calculator.

358

High dose ratio (HDR) cervical ring applicator to control bleeding from cervical carcinoma.  

Science.gov (United States)

The objective of this study was to evaluate the use of the high dose rate (HDR) cervical ring applicator to control acute cervical bleeding from carcinoma of the uterine cervix. This study consists of 15 patients presenting with invasive carcinoma of the uterine cervix with acute vaginal bleeding requiring transfusion. Initial irradiation, delivered emergently because of vaginal bleeding, consisted of two fractions (5 Gy each fraction to the surface of the cervix) utilizing the HDR intracavitary vaginal ring applicator. Two fractions were administered at one week intervals for a total of 10 Gy to the surface of the cervix. Irradiation doses from the HDR ring applications were not considered into the composite total dose to point A. Diagnostic imaging evaluation and initiation of external irradiation were commenced during this initial weekly interval between fractions. Vaginal bleeding requiring no additional transfusions was achieved in 93% (14/15) of patients. No acute or long-term Grades 3, 4, or 5 bowel or bladder sequelae were noted. In conclusion, HDR cervical ring brachytherapy is effective in controlling acute vaginal bleeding and can be delivered without undue acute or long-term toxicity. PMID:11913357

Grigsby, Perry W; Portelance, L; Williamson, J F

2002-01-01

359

Biomarkers in Cervical Cancer  

Directory of Open Access Journals (Sweden)

Full Text Available Cervical cancer, a potentially preventable disease, remains the second most common malignancy in women worldwide. Human papillomavirus (HPV is the single most important etiological agent in cervical cancer, contributing to neoplastic progression through the action of viral oncoproteins, mainly E6 and E7. Cervical screening programs using Pap smear testing have dramatically improved cervical cancer incidence and reduced deaths, but cervical cancer still remains a global health burden. The biomarker discovery for accurate detection and diagnosis of cervical carcinoma and its malignant precursors (collectively referred to as high-grade cervical disease represents one of the current challenges in clinical medicine and cytopathology.

Eun-Kyoung Yim

2006-01-01

360

Current Evidence on Uterine Embolization for Fibroids  

OpenAIRE

Strong evidence for both safety and effectiveness of uterine fibroid embolization has been generated since the procedure's introduction. This review will focus on the key articles representing the best evidence to summarize the outcomes from uterine embolization. This review will attempt to answer three important questions associated with uterine embolization. First, does uterine embolization relieve symptoms caused by uterine fibroids? Second, how well does the improvement in symptoms and qu...

Spies, James B.

2013-01-01

361

Biomarkers in Cervical Cancer  

OpenAIRE

Cervical cancer, a potentially preventable disease, remains the second most common malignancy in women worldwide. Human papillomavirus (HPV) is the single most important etiological agent in cervical cancer, contributing to neoplastic progression through the action of viral oncoproteins, mainly E6 and E7. Cervical screening programs using Pap smear testing have dramatically improved cervical cancer incidence and reduced deaths, but cervical cancer still remains a global health burden. The bio...

Eun-Kyoung Yim; Jong-Sup Park

2006-01-01

362

Posterior Reversible Encephalopathy Syndrome Occurring After Uterine Artery Embolization for Uterine Myoma  

International Nuclear Information System (INIS)

This case report describes posterior reversible encephalopathy syndrome (PRES) occurring after uterine artery embolization (UAE) for uterine myoma. This is the first report of PRES occurring after uterine vascular radiologic intervention. The mechanism by which UAE induced PRES is unclear.

363

Induction of labor using double balloon cervical device in women with previous cesarean section: Experience and review  

OpenAIRE

Induction of labour remains one of the most challenging interventions in current obstetrics. Different pharmaceuticals have been used for cervical ripening such as prostaglandins; however they can lead to a number of potential inconvenient risks namely uterine tachysystole and pathological fetal cardiotocography (CTG). In cases of women with previous caesarean births, using prostaglandins would pose even higher risks such as uterine rupture and perinatal mortality. A mechanical method of cer...

Nassif, N.; Ebeid, E.

2013-01-01

364

Uterine development and endometrial programming.  

Science.gov (United States)

Structural patterning and functional programming of uterine tissues are mechanistically coupled. These processes ensure anteroposterior differentiation of uterine tissues from adjacent segments of the developing female reproductive tract (FRT) and radial patterning that establishes uterine-specific histoarchitecture and functionality. Uterine organogenesis begins prenatally and is completed postnatally. Genes required for FRT development include Pax2, Lim1 and Emx2, genes in the abdominal-B Hoxa cluster, and members of both Wnt and Hedgehog (Hh) gene families. Disruption of morphoregulatory gene expression patterns can prevent FRT development entirely or compromise uterine organogenesis specifically. Oestrogen receptor-alpha (ER) -dependent events associated with development of the neonatal porcine uterus can be altered by administration of oestrogen (E) or relaxin (RLX). Expression of the RLX receptor is detectable in porcine endometrium at birth, before onset of ER expression and uterine gland genesis. Uterotrophic effects of both E and RLX can be inhibited with the ER antagonist ICl 182,780, indicating that RLX may act via crosstalk with the ER system in neonatal tissues. Exposure of neonatal gilts to E alters temporospatial patterns of Hh, Wnt and Hoxa expression in the uterine wall. Oestrogen given for two weeks from birth produced hypoplastic adult porcine uteri that were less responsive to periattachment conceptus signals as reflected by reduced growth response and luminal fluid protein accumulation, altered endometrial gene expression, and reduced capacity for conceptus support. Data reinforce the concept that factors affecting signalling events in uterine tissues that produce changes in morphoregulatory gene expression patterns during critical organisational periods can alter the developmental trajectory of the uterus with lasting consequences. Thus, uterine tissues can be programmed epigenetically for success or failure during perinatal life. PMID:16866313

Bartol, F F; Wiley, A A; Bagnell, C A

2006-01-01

365

A case of primary retroperitoneal undifferentiated endometrial stromal sarcoma after concurrent chemoradiation therapy for cervical cancer  

OpenAIRE

Endometrial stromal sarcoma (ESS) is a relatively rare uterine sarcoma, especially extrauterine ESS. Furthermore, retroperitoneal ESS are extremely rare. Up to now, there are only four cases of primary retroperitoneal ESS reported in the literature. We report one case of primary retroperitoneal undifferentiated endometrial stromal sarcoma after concurrent chemoradiation therapy for cervical cancer with a brief review of the literature.

Kang, Woo Dae; Kim, Cheol Hong; Cho, Moon Kyung; Kim, Jong Woon; Kim, Yoon Ha; Choi, Ho Sun; Kim, Seok Mo

2008-01-01

366

Clinical efficiency investigation of laparoscopic uterine artery occlusion combined with myomectomy for uterine fibroids  

OpenAIRE

To investigate the effectiveness of laparoscopic uterine artery occlusion combined with myomectomy for uterine fibroids. From August 2008 to August 2009, forty-eight women with uterine fibroids desiring to preserve their uteri underwent laparoscopic myomectomy. Among them, 18 women received laparoscopic uterine artery occlusion before uterine myomectomy while the others received laparoscopic myomectomy only. All of the 48 cases with uterine fibroids underwent laparoscopic myomectomy successfu...

Yin, Xiang-hua; Gao, Ling-ling; Gu, Yang; Song, Jing-zhe; Gao, Jing; Ji, Xiao-ping

2014-01-01

367

Shape Priors for Segmentation of the Cervix Region Within Uterine Cervix Images  

OpenAIRE

The work focuses on a unique medical repository of digital uterine cervix images (“cervigrams”) collected by the National Cancer Institute (NCI), National Institute of Health, in longitudinal multiyear studies. NCI together with the National Library of Medicine is developing a unique web-based database of the digitized cervix images to study the evolution of lesions related to cervical cancer. Tools are needed for the automated analysis of the cervigram content to support the cancer resea...

Lotenberg, Shelly; Gordon, Shiri; Greenspan, Hayit

2008-01-01

368

Uterine prolapse in a 19 year old pregnant woman: a case report  

OpenAIRE

It is well-known that multiparity and advanced age are major risk factors for pelvic organ prolapse which can rarely complicate pregnancy. We present the youngest case of uterine prolapse during pregnancy. She admitted with ruptured membranes at the 36th week of gestation and irreducible prolapse. As the edematous and thick, trapped and ulcerated cervix was not reducible, labor was obstructed due to cervical dystocia and a cesarean delivery was decided. A live male infant weighing 3100 gram w...

Harun Toy; Hakan Camuzcuo?lu; Halef Ayd?n

2009-01-01

369

Chromosomal imbalances in four new uterine cervix carcinoma derived cell lines  

OpenAIRE

Abstract Background Uterine cervix carcinoma is the second most common female malignancy worldwide and a major health problem in Mexico, representing the primary cause of death among the Mexican female population. High risk human papillomavirus (HPV) infection is considered to be the most important risk factor for the development of this tumor and cervical carcinoma derived cell lines are very useful models for the study of viral carcinogenesis. Comparative Genomic Hybridization (CGH) experim...

Vázquez Guelaguetza; Taja Lucía; Arana Rosa Ma; Monroy Alberto; Hidalgo Alfredo; Salcedo Mauricio

2003-01-01

370

Bulky scalp metastasis and superior sagittal sinus thrombosis from a cervical adenocarcinoma: an unusual case  

International Nuclear Information System (INIS)

Distant cutaneous metastases from cervical malignancies are uncommon, with scalp metastases being exceptional events. We present the case of a 53-year-old postmenopausal lady with adenocarcinoma of the uterine cervix that metastasized to the scalp with superior sagittal sinus thrombosis 8 months after diagnosis. In contrast to the seven prior cases of scalp metastases of cervical squamous cell carcinoma reported in published reports, ours is the first documentation of such an occurrence in cervical adenocarcinoma. Superior sagittal sinus thrombosis has not been reported with this tumour in the past.

371

Patterns of uterine enhancement with helical CT  

International Nuclear Information System (INIS)

Objective: The purpose of this study was to evaluate the enhancement characteristics of the normal uterine body and cervix using dynamic contrast-enhanced helical CT. Methods: Thirty-eight women scheduled for pelvic CT for non-gynecologic malignancies underwent dynamic contrast-enhanced helical CT of the pelvis. Data acquisition was during the arterial phase (30-45 s after the start of injection), the parenchymal phase (90-120 s after the start of injection), and delayed phase (3-9 min after the start of injection). The images were evaluated by four radiologists for the pattern of myometrial and cervical enhancement. Correlation was made with the age and menstrual status of the patients. Results: In the uterine body, three types of enhancement were observed. Type 1 enhancement, seen in 16 patients (42%), was characterized by the visualization of a subendometrial zone of enhancement, 30-120 s after the start of injection. Eight of these patients also showed an enhancing zone in the outer myometrium. Both zones were transitory, and in all cases, the uterus became homogeneous in the delayed phase. This pattern was seen predominantly in premenopausal women with a mean age of 34 years. Type 2 enhancement, seen in 17 cases (45%), was defined by the absence of subendometrial enhancement in the early phase. Enhancement was either diffuse from the outset or originated in the outer myometrium. This pattern was seen nearly equally in premenopausal and postmenopausal women with amenopausal and postmenopausal women with a mean age of 40 years. Type 3 enhancement was seen in five postmenopausal patients (13%) with a mean age of 53 years and was characterized by faint diffuse enhancement. In the cervix, a zonal pattern of enhancement defining inner and outer stroma was seen in 23 patients (61%). Fifteen patients were premenopausal and eight were postmenopausal. Conclusion: In this study, we have shown a transitory zonal distribution of the contrast in the myometrium and cervix using dynamic contrast-enhanced helical CT. The demonstration of these patterns is not constant and depends on individual variables. Of these, the menopausal status and/or age of the patient appear to be most important. While CT is not the primary imaging modality to evaluate the uterus, knowledge of these normal findings might help when confronted with unusual uterine enhancement during routine studies obtained with spiral CT. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

372

Patterns of uterine enhancement with helical CT  

Energy Technology Data Exchange (ETDEWEB)

Objective: The purpose of this study was to evaluate the enhancement characteristics of the normal uterine body and cervix using dynamic contrast-enhanced helical CT. Methods: Thirty-eight women scheduled for pelvic CT for non-gynecologic malignancies underwent dynamic contrast-enhanced helical CT of the pelvis. Data acquisition was during the arterial phase (30-45 s after the start of injection), the parenchymal phase (90-120 s after the start of injection), and delayed phase (3-9 min after the start of injection). The images were evaluated by four radiologists for the pattern of myometrial and cervical enhancement. Correlation was made with the age and menstrual status of the patients. Results: In the uterine body, three types of enhancement were observed. Type 1 enhancement, seen in 16 patients (42%), was characterized by the visualization of a subendometrial zone of enhancement, 30-120 s after the start of injection. Eight of these patients also showed an enhancing zone in the outer myometrium. Both zones were transitory, and in all cases, the uterus became homogeneous in the delayed phase. This pattern was seen predominantly in premenopausal women with a mean age of 34 years. Type 2 enhancement, seen in 17 cases (45%), was defined by the absence of subendometrial enhancement in the early phase. Enhancement was either diffuse from the outset or originated in the outer myometrium. This pattern was seen nearly equally in premenopausal and postmenopausal women with a mean age of 40 years. Type 3 enhancement was seen in five postmenopausal patients (13%) with a mean age of 53 years and was characterized by faint diffuse enhancement. In the cervix, a zonal pattern of enhancement defining inner and outer stroma was seen in 23 patients (61%). Fifteen patients were premenopausal and eight were postmenopausal. Conclusion: In this study, we have shown a transitory zonal distribution of the contrast in the myometrium and cervix using dynamic contrast-enhanced helical CT. The demonstration of these patterns is not constant and depends on individual variables. Of these, the menopausal status and/or age of the patient appear to be most important. While CT is not the primary imaging modality to evaluate the uterus, knowledge of these normal findings might help when confronted with unusual uterine enhancement during routine studies obtained with spiral CT. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

Kaur, H.; Loyer, E.M.; Charnsangavej, C. [Department of Diagnostic Radiology, Box 57, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd. Houston, TX 77030 (United States); Minami, M. [Department of Radiology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113 (Japan)

1998-10-01

373

Uterine Artery Anatomy Relevant to Uterine Leiomyomata Embolization  

International Nuclear Information System (INIS)

To categorize the anatomic variants of uterine arteries, and determine the incidence of menopausal symptoms where the tubo-ovarian branches were seen prior to embolization. Between July 1997 and June 2000, 257 (n = 257) uterine fibroid embolizations were performed at our institution. Arteriograms were retrospectively evaluated. Uterine arteries were classified into groups: type I (the uterine artery as first branch of the inferior gluteal artery), type II (the uterine artery as second or third branch of the inferior gluteal artery), type III (the uterine artery, the inferior gluteal and the superior gluteal arteries arising as a trifurcation), type IV (the uterine artery as first branch of the hypogastric artery), inconclusive, or not studied. Tubo-ovarian branches were recorded if visualized prior to and/or after embolization. Menopausal symptoms were recorded (n = 175 at 3 months, n = 139 at 6 months, n = 98 at 1 year, n = 22 at 2 years) using written questionnaires. Five hundred and fourteen uterine arteries (n = 514) were evaluated. There were 38% classifiable types, 23% inconclusive, and 39% not studied. Classification was as follows: type I, 45%; type II, 6%; type III, 43%; type IV, 6%. Among 256 patients, tubo-ovarian arteries were seen in 36 prior to embolization, but not afterwards. In this group, 25 patients reported transient menopausal symptoms (hot flashes, amenorrhea). Five patients did not report any menopausal symptoms. Six patients did not answer the symptoms. Six patients did not answer the questionnaires. Type I is the most common type of anatomy, followed by type III. The tubo-ovarian arteries may be visualized prior to and/or after embolization. The embolization was monitored to avoid embolization of the tubo-ovarian branches. Menopausal symptoms were transient all patients when the tubo-ovarian branches were seen prior to embolization

374

Studies on hyperthermia and radiation treatment of uterine cancer using multicellular tumor spheroid  

International Nuclear Information System (INIS)

Anticancer effects of hyperthermia and radiation on uterine cancer cells were studied using multicellular tumor spheroids and monolayer cultured cells. Cell lines used were SKG-3a(uterine cervical epidermoid carcinoma), HeLa-S3(uterine cervical adenocarcinoma) and HEC-59(uterine corpus adenocarcinoma). 1) All cell lines grown in monolayer culture have similar growth rates, but as spheroids, their growth rate are HeLa-S3>HEC-59>SKG-3a cells. 2) The radiosensitivity of all cell lines in monolayer are as follows according to dose-survival relationships.: HEC-59>HeLa-S3>SKG-3a cells. 3) Survival assay to hyperthermia on SKG-3a and HEC-59 cells resulted in no response from 370 to 410C and in cytotoxity over 420C. There is no defference in sensitivity to hyperthermia between the two types of cells. 4) The responses of three cell lines grown as spheroids in hyperthermia and radiation demonstrated that the combination therapy is not effective on the SKG-3a cell, but induced a 1.3-fold effectiveness ratio in HEC-59 and 1.6-fold in HeLa-S3 cells, i.e. more cytotoxity than with radiation alone. These results suggests that hyperthermia and radiation employed together may be more effective on radioresistant adenocarcinoma cells than on radiosensitive epidermoid carcinoma cells. (author)

375

Treatment results of liquid nitrogen cryotherapy on selected pathologic changes of the uterine cervix.  

Science.gov (United States)

One hundred and eighty-two women treated with cryotherapy were included in the study. In cases of chronic cervical inflammation full recovery was observed in 86% of subjects. In cases of Naboth cysts full recovery was observed within 6 to 8 weeks in 89% of women. In cases of cervical erosions full recovery was observed within 6 to 9 weeks in 84.9% of women. In women, with cervical epithelium dysplasia full recovery was observed within 7 to 11 weeks in treated subjects. Renewal of the pathology was observed in 15% of the women with treated cervicitis and in one of the women with cervical dysplasia within 2 to 5 years of follow-up. PMID:10459454

Kourounis, G; Iatrakis, G; Diakakis, I; Sakellaropoulos, G; Ladopoulos, I; Prapa, Z

1999-01-01

376

Concurrent chemoradiation therapy for advanced cervical cancer  

International Nuclear Information System (INIS)

In 2003, we began a clinical application of concurrent chemoradiation therapy (CCR) in patients with cervical cancer in our hospital. We analyzed 14 cases of advanced cervical cancer in stages IIa through IIIb by International Federation of Gynecology and Obstetrics (FIGO) classification. Tumor size of the uterine cervix ranged from 1.5 cm to 8.0 cm in diameter. Patients received radiation therapy (50 Gy of external beam radiotherapy for pelvis and 20 Gy of high-dose rate intracavitary brachytherapy) combined with chemotherapy. Cisplatin was administered intravenously every 3 weeks at a dose of 70 mg/m2 during the radiation therapy. In two cases, CCR was stopped because of the side effects. One case developed acute renal failure and another suffered intolerable exhaustion. As for the antitumor effects of CCR, the response rate was 75% (complete response (CR) 58.3%, partial response (PR) 16.7%). At the end of the CCR, 10 of 12 patients (83.3%) were negative for viable cells by cytology or biopsy of the uterine cervix. The grade 3 adverse effects were leukopenia, diarrhea and anemia. There was no statistical difference in the overall survival between CCR and radiation therapy alone. The CCR response rate in patients with paraaortic lymph node swelling (suspected metastasis) was low, and they had a poor prognosis. Further examinations for the long-term survival benefit of CCR are necessary. (author)

377

Soil and Sediment Erosion  

Science.gov (United States)

This brief article discusses the effect of soil and sediment erosion and its significance in social and economic aspects. The methods of measuring erosion and knowledge of past erosion rates are also briefly discussed to use as a predictor of future erosion rates.

378

What Should You Ask Your Doctor about Uterine Sarcoma?  

Science.gov (United States)

... for uterine sarcoma? What should you ask your doctor about uterine sarcoma? It is important for you ... and Staging Treating Uterine Sarcoma Talking With Your Doctor After Treatment What`s New in Uterine Sarcoma Research? ...

379

Imaging of uterine cervix carcinoma  

International Nuclear Information System (INIS)

Imaging of uterine cervix carcinoma has evolved during the last decade. Recent developments in magnetic resonance imaging have expanded the role of MRI in evaluating the pathology of uterine cervix carcinoma. MRI is now the modality of choice for tumor staging, evaluating tumor response to treatment, diagnosing recurrences and for evaluating pregnant patients. MRI images will soon be used to calculate dosimetry for brachytherapy with matching and fusion software. (author)

380

Radiological appearances of uterine fibroids  

OpenAIRE

Uterine fibroids, also known as leiomyomas, are the commonest uterine neoplasms. Although benign, they can be associated with significant morbidity and are the commonest indication for hysterectomy. They are often discovered incidentally when performing imaging for other reasons. Usually first identified with USG, they can be further characterized with MRI. They are usually easily recognizable, but degenerate fibroids can have unusual appearances. In this article, we describe the appearances ...

Sue, Wilde; Sarah, Scott-barrett

2009-01-01

381

Soil Erosion Studies  

OpenAIRE

Soil erosion affects a large part of the Earth surface, and accelerated soil erosion is recognized as one of the main soil threats, compromising soil productive and protective functions. The land management in areas affected by soil erosion is a relevant issue for landscape and ecosystems preservation. In this book we collected a series of papers on erosion, not focusing on agronomic implications, but on a variety of other relevant aspects of the erosion phenomena. The book is divided into th...

Godone, Danilo Francesco; Stanchi, Silvia

2011-01-01

382

Wind Erosion Research  

Science.gov (United States)

Wind Erosion Research (WER) provides science-based wind erosion technology for environmentally, economically, and socially sustainable agriculture in the United States. This website introduces the Wind Erosion Equation (WEQ), the first model for estimating soil loss by wind from agricultural fields and the newly developed Wind Erosion Prediction System (WEPS) which provides new capabilities assessing plant damage and calculating suspension loss. Simulation models, multimedia archive and history of wind erosion research are available for educators and students.

2006-02-27

383

Mapping erosion from space  

OpenAIRE

Soil erosion by water is the most important land degradation problem worldwide. Spatial information on erosion is required for defining effective soil and water conservation strategies. Satellite remote sensing can provide relevant input to regional erosion assessment. This thesis comprises a review on how satellite data have been used previously for evaluating water erosion. Options include erosion detection and the assessment of controlling factors such as topography, soil, and vegetation. ...

Vrieling, A.

2007-01-01

384

Anterior cervical foramenotomy for cervical radiculopathy.  

OpenAIRE

Anterior cervical discectomy (ACD) is standard practice for cervical radiculopathy. Irrespective of the precise method used, it involves more or less complete disc removal with resultant anatomical and biomechanical derangements, and frequently the insertion of a bone or prosthetic graft. Anterior cervical foramenotomy is an alternative procedure that allows effective anterior decompression of the nerve root and lateral spinal cord, whilst conserving the native disc, preserving normal anatomy...

White, Bd; Buxton, N.; Fitzgerald, Jj

2007-01-01

385

Prognostic value of cervical size and lymph node status assessed by computed tomography for patients with cervical cancer treated with irradiation  

International Nuclear Information System (INIS)

Purpose: to evaluate the prognostic value of cervical size and lymph node status assessed by computed tomography (CT) in uterine cervical carcinoma treated with irradiation. Methods and materials: 181 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIA-IVA cervical carcinoma treated with irradiation were analysed. Univariate and multivariate analyses using the Cox regression model were performed to determine statistical significance of some tumor-related factors. Results: The FIGO stage showed significant influence on local failure: IIA - 0%, IIB - 13.1%, IIIA - 20.0%, IIIB - 24.8%, IVA - 0%. Overall survival for stage III (62.8%) significantly lower than for stage II (89.7%), p= 0.0001. Cervical size (>60 mm) and lymph node status (>10 mm) assessed on CT had impact on overall survival and disease free survival. Conclusion. Cervical size and pelvic lymph node status assessed by CT are the significant prognostic factors for patients with uterine cervical carcinoma treated with irradiation. (author)

386

Paraaortic lymph node irradiation in cervical carcinoma without prior lymphadenectomy  

International Nuclear Information System (INIS)

A study of complications associated with paraaortic irradiation was undertaken in patients with uterine cervical cancer who had not undergone prior lymphadenectomy. Between 1975 and 1984, 29 highly selected patients received paraaortic irradiation as part of their definitive treatment for cervical carcinoma. Paraaortic fields were irradiated to a total dose of 4,200-5,000 rad (42-50 Gy), in fractions of 150-180 rad (1.5-1.8 Gy). An anteroposterior-posteroanterior technique was generally used. All fields were treated every day. There were no instances of small-bowel obstruction or other major complications, surgical procedures, or deaths caused by paraaortic irradiation. Eleven patients (38%) have no evidence of recurrent disease 23-120 months after completion of therapy. Paraaortic irradiation was well tolerated in this patient group without prior staging lymphadenectomy. Thus, in selected patients and with appropriate techniques, paraaortic irradiation for cervical carcinoma may be used with relative safety

387

Preprocessing: A Step in Automating Early Detection of Cervical Cancer  

CERN Document Server

Uterine Cervical Cancer is one of the most common forms of cancer in women worldwide. Most cases of cervical cancer can be prevented through screening programs aimed at detecting precancerous lesions. During Digital Colposcopy, colposcopic images or cervigrams are acquired in raw form. They contain specular reflections which appear as bright spots heavily saturated with white light and occur due to the presence of moisture on the uneven cervix surface and. The cervix region occupies about half of the raw cervigram image. Other parts of the image contain irrelevant information, such as equipment, frames, text and non-cervix tissues. This irrelevant information can confuse automatic identification of the tissues within the cervix. Therefore we focus on the cervical borders, so that we have a geometric boundary on the relevant image area. Our novel technique eliminates the SR, identifies the region of interest and makes the cervigram ready for segmentation algorithms.

Das, Abhishek; Bhattacharyya, Debasis

2011-01-01

388

Preprocessing for Automating Early Detection of Cervical Cancer  

CERN Document Server

Uterine Cervical Cancer is one of the most common forms of cancer in women worldwide. Most cases of cervical cancer can be prevented through screening programs aimed at detecting precancerous lesions. During Digital Colposcopy, colposcopic images or cervigrams are acquired in raw form. They contain specular reflections which appear as bright spots heavily saturated with white light and occur due to the presence of moisture on the uneven cervix surface and. The cervix region occupies about half of the raw cervigram image. Other parts of the image contain irrelevant information, such as equipment, frames, text and non-cervix tissues. This irrelevant information can confuse automatic identification of the tissues within the cervix. Therefore we focus on the cervical borders, so that we have a geometric boundary on the relevant image area. Our novel technique eliminates the SR, identifies the region of interest and makes the cervigram ready for segmentation algorithms.

Das, Abhishek; Bhattacharyya, Debasis

2011-01-01

389

Endometrial cancer with cervical extension mimicking dual concordant endometrial and cervical malignancy by F18 FDG PET and MRI  

International Nuclear Information System (INIS)

A 35 year old woman with endometrial cancer and cervical extension underwent F18 FDG PET CT and MRI studies after resection of a cervical mass presumed to be cervical myoma. The patient underwent cervical myomectomy and the histopathologic report revealed poorly differentiated invasive carcinoma. Cervical cancer was ruled out because the patient had no history of sexual intercourse and was negative for human papilloma virus infection. The patient underwent radical hysterectomy, bilateral salpingo oophorectomy, pelvic and para aortic lymph node dissection, and multiple biopsies. F18 FDG PET CT showed intense FDG uptake along the cervix wall. T2 weighted MRI also revealed a mass lesion with high SI involving the anterior and posterior lips of the uterine cervix. Another area of focal increased uptake above the endometrial lesion in the left pelvic cavity was observed on PET CT and MRI, possibly due to a functioning ovary. PET CT and MRI were interpreted as showing a dual concordant malignant lesion due to separated FDG uptakes and high SI without any connection between the cervical and endometrial lesions. F18 FDG PET CT showed intense FDG uptake along the endometrium. Given the patient's history and the fact that she was not menstruating at the time of imaging, this intense uptake was interpreted as another pathologic lesion, suggesting dual primary lesions. A suspected heterogeneous mass lesion along the endometrium suggesting concordant endometrial cancer was found o concordant endometrial cancer was found on MRI. Endometrial cancer with cervical extension is sometimes difficult to differentiate from primary cervical cancer. The final histopathologic report showed poorly differentiated endometrial adenocarcinoma with cervical extension, although the FDG PET CT and MRI findings were suggestive of concordant cervical and endometrial cancer. Although histopathologic confirmation is necessary for final diagnosis, MRI and FDG PET CT studies may aid in the differential diagnosis. A metastatic cervical mass from endometrial cancer clinically presenting as cervical myoma is rare. This case suggests that poorly differentiated endometrial cancer may extend into the cervix, presenting as cervical myoma, and the possibility of a metastatic mass should be considered in the differential diagnosis when dealing with cervical myoma

390

Endometrial cancer with cervical extension mimicking dual concordant endometrial and cervical malignancy by F18 FDG PET and MRI  

Energy Technology Data Exchange (ETDEWEB)

A 35 year old woman with endometrial cancer and cervical extension underwent F18 FDG PET CT and MRI studies after resection of a cervical mass presumed to be cervical myoma. The patient underwent cervical myomectomy and the histopathologic report revealed poorly differentiated invasive carcinoma. Cervical cancer was ruled out because the patient had no history of sexual intercourse and was negative for human papilloma virus infection. The patient underwent radical hysterectomy, bilateral salpingo oophorectomy, pelvic and para aortic lymph node dissection, and multiple biopsies. F18 FDG PET CT showed intense FDG uptake along the cervix wall. T2 weighted MRI also revealed a mass lesion with high SI involving the anterior and posterior lips of the uterine cervix. Another area of focal increased uptake above the endometrial lesion in the left pelvic cavity was observed on PET CT and MRI, possibly due to a functioning ovary. PET CT and MRI were interpreted as showing a dual concordant malignant lesion due to separated FDG uptakes and high SI without any connection between the cervical and endometrial lesions. F18 FDG PET CT showed intense FDG uptake along the endometrium. Given the patient's history and the fact that she was not menstruating at the time of imaging, this intense uptake was interpreted as another pathologic lesion, suggesting dual primary lesions. A suspected heterogeneous mass lesion along the endometrium suggesting concordant endometrial cancer was found on MRI. Endometrial cancer with cervical extension is sometimes difficult to differentiate from primary cervical cancer. The final histopathologic report showed poorly differentiated endometrial adenocarcinoma with cervical extension, although the FDG PET CT and MRI findings were suggestive of concordant cervical and endometrial cancer. Although histopathologic confirmation is necessary for final diagnosis, MRI and FDG PET CT studies may aid in the differential diagnosis. A metastatic cervical mass from endometrial cancer clinically presenting as cervical myoma is rare. This case suggests that poorly differentiated endometrial cancer may extend into the cervix, presenting as cervical myoma, and the possibility of a metastatic mass should be considered in the differential diagnosis when dealing with cervical myoma.

Yoon, Seok Nam [Kwandong Univ. College of Medicine, Seoul (Korea, Republic of)

2012-09-15

391

Rapid developing basaloid squamous cell carcinoma of the uterine cervix in a young adult Taiwanese.  

Science.gov (United States)

Basaloid squamous cell carcinoma (BSCC) of the uterine cervix is a rare malignancy of the female genital tract with a poorer clinical outcome than SCC of the uterine cervix. We report a case of BSCC of the uterine cervix developing rapidly in a young adult Taiwanese. A 35-year-old woman, Para 2, visited the emergency room with severe dizziness, palpitations and sudden excessive vaginal bleeding with hemoglobin of 3.6 g/dl. She had been well and healthy but intermittent vaginal spotting developed for around 6 months previously and was treated as abnormal uterine bleeding by ob-gyn practitioners. She had a repeat cesarean operation 16 months prior to this episode and the last Pap smear showed reactive change 12 months ago at our hospital. On examination, she had an ulcerated, necrotic, and punched-out lesion of 5 cm of the cervix. A cervical biopsy revealed poorly differentiated typical BSCC. Abdominal/pelvic computerized tomography and whole body positron emission tomography confirmed FIGO staging IB2. She responded well to concurrent chemoradiotherapy. Follow-up for the patient is ongoing. This is a rapid developing BSCC of the uterine cervix, although we cannot actually ascertain when it started and how rapidly it progressed. PMID:24362481

Tsai, H J; Liou, B; Li, M C

2013-12-01

392

Packing effects on the intracavitary radiation therapy of the uterine cervix cancer  

International Nuclear Information System (INIS)

Purpose of the radio-therapy is maximize the radiation dose to the tumor while minimizing the dose to the critical organ. Carcinoma of the uterine cervix treatment are external irradiation or an interstitial brachytherapy make use of isotope. Brachytherapy is a method of radiotherapy in advantage to achieve better local control with minimum radiation toxicity in comparison with external irradiation because radiation dose is distributed according to the inverse square low of gamma-ray emitted from the implanted sources. Authors make use of the patients data which 192Ir gives medical treatment intracavity. Intracavitary radiation of the uterine cervix cancer, critical organ take 20% below than exposure dose of A point in the ICRU report. None the less of the advice, Radiation proctitis and radiation cystitis are frequent and problematic early complications in patients treated with radiation for the uterine cervix cancer. In brachytherapy of uterine cervical cancer using a high dose rate remote afterloading system, it is of prime importance to deliver a accurate dose in each fractionated treatment by minimizing the difference between the pre-treatment planned and post-treatment calculated doses. Use of packing to reduce late complications intracavitary radiation of the uterine cervix cancer. Bladder and rectum changes exposure dose rate by radiotherapy make use of packing.

393

Packing effects on the intracavitary radiation therapy of the uterine cervix cancer  

Energy Technology Data Exchange (ETDEWEB)

Purpose of the radio-therapy is maximize the radiation dose to the tumor while minimizing the dose to the critical organ. Carcinoma of the uterine cervix treatment are external irradiation or an interstitial brachytherapy make use of isotope. Brachytherapy is a method of radiotherapy in advantage to achieve better local control with minimum radiation toxicity in comparison with external irradiation because radiation dose is distributed according to the inverse square low of gamma-ray emitted from the implanted sources. Authors make use of the patients data which {sup 192}Ir gives medical treatment intracavity. Intracavitary radiation of the uterine cervix cancer, critical organ take 20% below than exposure dose of A point in the ICRU report. None the less of the advice, Radiation proctitis and radiation cystitis are frequent and problematic early complications in patients treated with radiation for the uterine cervix cancer. In brachytherapy of uterine cervical cancer using a high dose rate remote afterloading system, it is of prime importance to deliver a accurate dose in each fractionated treatment by minimizing the difference between the pre-treatment planned and post-treatment calculated doses. Use of packing to reduce late complications intracavitary radiation of the uterine cervix cancer. Bladder and rectum changes exposure dose rate by radiotherapy make use of packing.

Cho, Jung Kun; Lee, Du Hyun; Si, Chang Kun; Choi, Yoon Kyung; Kim, Tae Yoon [Proton Therapy Center, National Cancer Center, Seoul (Korea, Republic of)

2004-03-15

394

Pure basaloid squamous cell carcinoma of the uterine cervix: a case report.  

Science.gov (United States)

Basaloid squamous cell carcinoma of the uterine cervix is an extremely rare malignancy of the female genital tract with a poorer clinical outcome than squamous cell carcinoma of the uterine cervix. We report a case of pure basaloid squamous cell carcinoma of the uterine cervix. A 70-yr-old woman with vaginal bleeding was referred to our institute. A basaloid squamous cell carcinoma of the uterine cervix, of International Federation of Gynecology and Obstetrics (FIGO) stage Ib1, was diagnosed by a loop electrosurgical excision procedure cone biopsy. A radical hysterectomy was performed, along with bilateral salpingo-oophorectomy, pelvic lymph node dissection, and para-aortic lymph node sampling. Pathologic findings were consistent with a basaloid squamous cell carcinoma confined to the cervix without an extracervical tumor. No further treatment was administered and there was no clinical evidence of recurrence during the 12 months of follow-up. Follow-up for the patient is ongoing. Although basaloid squamous cell carcinoma of the uterine cervix is thought to behave aggressively, accumulation of data on these rare tumors is necessary to determine whether their behavior differs significantly from that of conventional cervical squamous cell carcinoma of similar clinical stage. These data would be useful for defining the best diagnosis and treatment for these rare tumors. PMID:19543425

Kwon, Yong Soon; Kim, Yong Man; Choi, Ga Won; Kim, Young Tak; Nam, Joo-Hyun

2009-06-01

395

Cervical Radiculopathy (Pinched Nerve)  

Science.gov (United States)

... by the American Academy of Orthopaedic Surgeons. Cervical Radiculopathy (Pinched Nerve) Some people have neck pain that ... The medical term for this condition is cervical radiculopathy. Understanding your spine and how it works can ...

396

ICSN - Cervical Cancer  

Science.gov (United States)

Skip to Main Content Search International Cancer Screening Network Sponsored by the National Cancer Institute Home | About ICSN | Collaborative Projects | Meetings | Cancer Sites | Publications | Contact Us Cervical Cancer (Archived Tables): Home Cervical

397

Biometric analysis of uterine cervix during pregnancy using trans vaginal ultrasonography and magnetic resonance imaging  

International Nuclear Information System (INIS)

Objective: To evaluate the uterine cervix length with magnetic resonance imaging in comparison with findings at trans vaginal ultrasonography. Materials and methods: Twenty pregnant women between the 19th and 30th gestational weeks underwent magnetic resonance imaging and trans vaginal ultrasonography for evaluation of their uterine cervix. Measurements by means of magnetic resonance imaging were performed by two specialists in imaging diagnosis for calculating the interobserver variability of the method. Results: Calculation of the Pearson's correlation coefficient between measurements of the cervical length demonstrated a significant correlation between the results of both methods (r=0.628; p<0.01). The paired t test demonstrated no statistically significant difference between measurements obtained by trans vaginal ultrasonography and magnetic resonance imaging (p=0.068). Interobserver agreement in cervical measurements by magnetic resonance imaging was high (?=0.96), demonstrating the reliability of the method. Conclusion: The comparison between both imaging methods in the evaluation of cervical biometry showed no statistically significant difference thus reinforcing the utilization of ultrasonography. However, in some cases where trans vaginal ultrasonography is contraindicated, magnetic resonance imaging can be alternatively utilized for measurement of the cervical length. (author)

398

Biometric analysis of uterine cervix during pregnancy using trans vaginal ultrasonography and magnetic resonance imaging  

Energy Technology Data Exchange (ETDEWEB)

Objective: To evaluate the uterine cervix length with magnetic resonance imaging in comparison with findings at trans vaginal ultrasonography. Materials and methods: Twenty pregnant women between the 19th and 30th gestational weeks underwent magnetic resonance imaging and trans vaginal ultrasonography for evaluation of their uterine cervix. Measurements by means of magnetic resonance imaging were performed by two specialists in imaging diagnosis for calculating the interobserver variability of the method. Results: Calculation of the Pearson's correlation coefficient between measurements of the cervical length demonstrated a significant correlation between the results of both methods (r=0.628; p<0.01). The paired t test demonstrated no statistically significant difference between measurements obtained by trans vaginal ultrasonography and magnetic resonance imaging (p=0.068). Interobserver agreement in cervical measurements by magnetic resonance imaging was high ({alpha}=0.96), demonstrating the reliability of the method. Conclusion: The comparison between both imaging methods in the evaluation of cervical biometry showed no statistically significant difference thus reinforcing the utilization of ultrasonography. However, in some cases where trans vaginal ultrasonography is contraindicated, magnetic resonance imaging can be alternatively utilized for measurement of the cervical length. (author)

Brandao, Rosieny Souza; Maciel Junior, Francisco da Silva [Centro de Diagnostico por Imagem (CDI), Vitoria, ES (Brazil)]. E-mail: rosienysbrandao@terra.com.br; Pires, Claudio Rodrigues [Cetrus - Centro de Treinamento de Ultra-Sonografia, Sao Paulo, SP (Brazil); Souza, Eduardo de; Moron, Antonio Fernandes; Mattar, Rosiane [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil). Dept. of Obstetrics

2008-07-15

399

Potential diagnostic value of P16 expression in premalignant and malignant cervical lesions  

Science.gov (United States)

Background: The goal of this study was to evaluate the results of the expression of p16INK4a in normal uterine cervical epithelium, low-grade cervical intraepithelial neoplasia (CIN), high-grade CIN, squamous cell carcinoma (SCC), and adenocarcinoma of the cervix, in order to help draw a distinction between low risk and high risk patients with cervical lesions. Materials ans Methods: P16INK4a expression was evaluated by immunohistochemistry in 78 paraffin-embedded tissue samples including 39 normal cervical tissues, 11 low-grade CINs, 11 high-grade CINs, 22 cervical SCCs and 8 cervical adenocarcinomas. Two parameters in immunohistochemical p16 expression were evaluated: percentage of p16-positive cells, and reaction intensity. Results: The p16INK4a expression rate was 81.8% in low-grade CINs, 91% in high-grade CINs, 90% in SCCs and 75% in cervical adenocarcinomas. 10% of normal cervical samples expressed p16. Moreover, there was a significant relationship between the histological diagnoses and percentage of positive cells and reaction intensity of p16 (p < 0.005). The intensity of the reaction was the