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Sample records for uterine cervical erosion

  1. Intravascular interventional therapy for uterine cervical adenocarcinoma

    International Nuclear Information System (INIS)

    Adenocarcinoma of the uterine cervix shows an upward trend in younger patients with poorer prognosis in comparing with squamous carcinoma. The traditional radiotherapy and intravenous route chemo- therapy are all difficult in treating uterine cervical adenocarcinoma due to different biomolecular characterization with that of the squamous cell carcinoma. Because of long term growth for primary lesion and infiltration with limitation inside the pelvis, provides a reliable clinico-pathologic basis for intra-vascular interventional treatment. This article presents a comprehensive statement of clinico-pathologic, biomolecular investigation and intravascular intervention for uterine cervical carcinoma. (authors)

  2. Uterine artery chemoembolization: its application in treating cervical pregnancy

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    Objective: To discuss the feasibility and safety of uterine artery chemoembolization in the treatment of cervical pregnancy. Methods: During the period of Sep. 2005-Dec. 2007, uterine artery chemoemboliztion was performed in 12 patients with cervical pregnancy in the authors' hospital. Via bilateral uterine arteries 100 mg MTX and 80,000 U Gentamycin were infused separately, after that the bilateral uterine arteries were embolized with gelfoam. Cleaning of the uterus and the cervix uteri was carried out in 24 -72 h after the procedure. Results: The technical success rate of bilateral uterine artery chemoembolization was 100%. The blood loss was 50-100 ml (mean 65 ml) during the procedure of cleaning the uterus and the cervix uteri. No serious complications occurred. Conclusion: Uterine artery chemoembolization is an effective and safe treatment for cervical pregnancy, which can greatly avoid unnecessary uterectomy and preserve fertility function. (authors)

  3. [Current Status and Perspective of Chemoradiotherapy for Uterine Cervical Cancer].

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    Toita, Takafumi; Ariga, Takuro; Kasuya, Goro; Hashimoto, Seiji; Maemoto, Hitoshi; Heianna, Joichi; Kakinohana, Yasumasa; Murayama, Sadayuki

    2015-10-01

    Fifteen years has passed since the NCI announced the clinical importance of concurrent chemoradiotherapy (CCRT) in radiotherapy for patients with locoregionally advanced uterine cervical cancer. Numerous clinical trials have been performed to further improve the outcomes of CCRT. In addition to investigations of chemotherapeutic regimens and schedules, adaptation of novel radiotherapy methods such as image-guided brachytherapy (IGBT) and intensity-modulated radiotherapy (IMRT) is encouraged in CCRT for cervical cancer. PMID:26489545

  4. Preoperative uterine artery embolization and evacuation in the management of cervical pregnancy: report of two cases.

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    Ryu, K. Y.; Kim, S R; Cho, S. H.; S.Y. Song

    2001-01-01

    Preoperative uterine artery embolization and cervical evacuation as conservative management of cervical pregnancy has been tried in recent years. However, cervical suturing, vasoconstrictor injection, or cervical ballooning was frequently used as an ancillary measures in those procedures in most of the previous studies. We report two cases of cervical pregnancy that were successfully treated with preoperative uterine artery embolization and removal of gestational material without ancillary pr...

  5. Pharmacokinetics of adriamycin vaginal suppository on uterine cervical cancer

    International Nuclear Information System (INIS)

    Vaginal suppositories of Adriamycin (ADM, 5 mg), for reducing the capacity for repair from sublethal damage of X-ray-irradiated cells, were prepared using Wipepsol S-55 as the vehicle, and were intravaginally administered to patients with advanced uterine cervical cancer, and their pharmacokinetics and clinical effects were studied. The ADM concentration in the uterine cervical cancer tissues indicated high levels (17 to 566 ?g/g), and migration into the cardinal ligament and regional lymph nodes was noted. However, little ADM was detected in serum (0 to 0.14 ?g/g), probably because of its molecular weight and excellent tissue absorbance, and no side effects, such as cardiotoxicity and myelosuppression due to consecutive administration were detected. Histologically, the effect obtained when administered alone was limited, administration in combination with radiotherapy being more effective. Accordingly, radiotherapy of advanced uterine cervical cancer with concomitant administration of ADM vaginal suppositories seems to bring about a more powerful antitumoral effect with fewer systemic side effects. (author)

  6. Short-course palliative radiotherapy for uterine cervical cancer

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    Kim, Dong Hyun; Lee, Ju Hye; Ki, Yong Kan; Kim, Won Taek; Park, Dahl; Kim, Dong Won [Dept. of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital, Busan (Korea, Republic of); Nam, Ji Ho; Jeon, Sang Ho [Dept. of Radiation Oncology, Pusan National University Yangsan Hospital, Yangsan (Korea, Republic of)

    2013-12-15

    The purpose of this retrospective study was to evaluate the efficacy and feasibility of short-course hypofractionated radiotherapy (RT) for the palliation of uterine cervical cancer. Seventeen patients with cancer of the uterine cervix, who underwent palliative hypofractionated 3-dimensional conformal radiotherapy between January 2002 and June 2012, were retrospectively analyzed. RT was delivered to symptomatic lesions (both the primary mass and/or metastatic regional lymph nodes). The total dose was 20 to 25 Gy (median, 25 Gy) in 5 Gy daily fractions. The median follow-up duration was 12.2 months (range, 4 to 24 months). The median survival time was 7.8 months (range, 4 to 24 months). Vaginal bleeding was the most common presenting symptom followed by pelvic pain (9 patients). The overall response rates were 93.8% and 66.7% for vaginal bleeding control and pelvic pain, respectively. Nine patients did not have any acute side effects and 7 patients showed minor gastrointestinal toxicity. Only 1 patient had grade 3 diarrhea 1 week after completion of treatment, which was successfully treated conservatively. Late complications occurred in 4 patients; however, none of these were of grade 3 or higher severity. Short-course hypofractionated RT was effective and well tolerated as palliative treatment for uterine cervical cancer.

  7. Clinical evaluation of postoperative radiotherapy for uterine cervical cancer

    International Nuclear Information System (INIS)

    Prognostic factors were reviewed in ninety-seven patients who underwent postoperative radiotherapy for uterine cervical cancer. All were treated by radical hysterectomy and pelvic lymphadenectomy. Indications for adjuvant radiotherapy included pelvic lymph node metastases, parametrial infiltration, vascular space involvement, a very close surgical margin, large primary lesion, adenocarcinoma/adenosquamous cell carcinoma, and uninvolved cervical tissue less than 3 mm. They were given 6 MV X ray to the whole pelvic space (ninety-three cases treated with center split). The total dose was 30-60 Gy, and four received intracavitary irradiation. Thirty-seven patients were in clinical stage Ib, fifteen were in IIa, and forty-five were in IIb. The five-year survival rate was 80.4%, 78.8%, 84.1% and the overall rate was 81.5%. There were twenty-five recurrences, four recurrences at local sites, fifteen at distant, and six at both. Of the recurrences, 60% were evident within 2 years, and the one-year survival rate from recurrences was 50%, which was comparatively good. As mentioned, postoperative radiotherapy for uterine cervical cancer appears to be effective. The prognostic factors included the number of pregnancy, abortion, histologic type, parametrial infiltration, and pelvic lymph node metastases. Those with these prognostic factors were in the high risk group. It is necessary for those in the high risk group to receive some adjuvant therapy, such as chemotherapy. (author)

  8. [Current developments in uterine cervical carcinoma prevention and screening].

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    Mathevet, P; Jacot-Guillarmod, M

    2015-10-28

    The causality between the HPV infection and the carcinoma of the uterine cervix is demonstrated. The benefits of the prophylactic HPV vaccine are emerging in the general population. This vaccine has no evident general side effect. So it is proposed for young women and young men. The commercialization of a nonavalent vaccine will increase its preventive activity. Already, international societies recommend using the HPV test for cervical carcinoma screening in replacement of the cytology in women more than 30-35 years old. In case of negative test, the interval between screenings can be increase until 5 years. In case of positive test, the cervical cytology is used for the triage, but other tests are under development. Due to the vaccine efficacy, the future modalities and the cost/benefits ratio of the screening should be questioned. PMID:26672178

  9. Second cancer after radiotherapy of the uterine cervical cancer

    International Nuclear Information System (INIS)

    To study the relative risk of second cancer after radiotherapy, we reviewed 2465 cases of uterine cervical cancer who were treated in our institute from 1962 to 1986 and were followed up for more than 5 years. Among them, 1502 cases were treated by radiotherapy with or without surgery (radiotherapy group), and the remainder were treated by surgery only (surgery only group). We defined second cancer as malignancy that occurred in another organ after an interval of 5 years or more from the end of treatment of the first cancer. The relative risk of second cancer was computed by the person-year method advocated by Schoenberg. Second cancer was observed among 8 cases of the surgery group, whereas 43 cases were observed among the radiotherapy group. The cases were: rectal cancer, 6 cases; bladder cancer, 4 cases. The observed and expected ratio (O/E ratio) was 4.02 in rectal cancer and 7.98 in bladder cancer. This incidence of the both cancers was significantly high in the radiotherapy group. Three of the 6 cases with rectal cancer underwent operation in our institute. The incubation periods between the first and second cancers were from 9 to 21 years. Each case exhibited symptoms of chronic radiation proctitis after radiotherapy for uterine cervical cancer. It is thought necessary to follow up such cases carefully to detect radiation induced cancer. (author)

  10. Late intestinal adverse effects of radiotherapy for uterine cervical cancer

    International Nuclear Information System (INIS)

    We investigated the incidence and clinical appearance of late adverse intestinal effects in 88 patients treated with postoperative radiotherapy and 46 patients treated with radiotherapy alone for uterine cervical cancer. In the postoperative radiotherapy group, colitis, ileus and bowel fistules were seen in 13 patients (14.8%), 8 (9.1%), and 3 (3.4%) of the patients, respectively. Of these patients, 11 (12.5%) needed to have surgical therapy for these adverse effects. In the radiation alone group, 18 patients (39.1%) had colitis and 2 (4.3%) had ileus; of them, 2 patients (4.3%) needed to have surgical therapy. The higher incidence of so severe adverse effects as to require surgical therapy in the postoperative radiotherapy group indicates that adhesion caused by operation might have caused the occurrence of these adverse effects. Four of a total of 134 patients died of causes which might be attributable to irradiation. In 61 patients treated by radical hysterectomy without postoperative radiotherapy, intestinal adverse effects were not found. These results indicate that late intestinal adverse effects after radiotherapy are likely to occur in some cases very severely; therefore, careful consideration is necessary in the decision to use radiotherpay for uterine cervical cancer. (J.P.N.)

  11. Assessment of Cervical Erosion in Hamedan City, Iran

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    Fatemeh Shobeiri

    2007-01-01

    Full Text Available The purpose of this study was to determine the role of socio-economic factors and cytology in cervical erosion. A cross-sectional study involving 410 females in the reproductive age group was conducted in urban health centers in Hamedan city, Iran. Data were collected through interviews with women, gynecological examination in the clinics in the health centers and laboratory tests. Cervical erosion was detected in 68 (16.6% females. Out of these mild dysplasia was seen in (8.8% females. High percentages of inflammatory smears (58.8% were obtained in women with cervical erosion. Cervical erosion was more common in illiterate and women with low literacy status as compared to women with higher education. Majority of cases of cervical erosion were detected in women with high parity. A statistically significant relationship was found between lower socio-economic status and cervical erosion (p< 0.05. Regular cytological screening by Pap smear will help in early detection of carcinoma cervix.

  12. Histological study on radiosensitivity of uterine cervical cancer

    International Nuclear Information System (INIS)

    Primary lesions in 80 cases of uterine cervical cancer were experimentally irradiated with 1000 R of telecobalt, and after 7 days, evaluation of their sensitivity was done. Since histological study of a given dose in a given period is indispensable, the dose of 1000 R and evaluation on the 7th day is clinically useful. A considerable correlation was noted between the level of sensitivity evaluated on the basis of our conventional histological criteria and the prognosis. But on the other hand, some gap was noted and an explanation for this was sought. The relationship between the interstitial reactions and the sensitivity was studied in 50 cases with uterine cervical cancer. In the high-sensitivity group, an abundant formation of granulation with numerous capillaries and a variety of acute exudative inflammations were found, and the lesion in the cancer nest showed a change, a so-called acute necrotic inflammation. Histological criteria for radiosensitivity were established by considering changes in both the parenchyma and stroma of the tumor, as mentioned above. Namely, the change in the parenchyma of the tumor considered to have good sensitivity are as follows: a) swelling and degeneration of the cancer cells are marked and diffuse, b) cancer nest shows the significant decrease in size, and c) viable cells and normal mitosis are few in the fundus of the cancer nest, etc. On the other hand, the changes of the stroma of the tumor are as follows: a) a large number of neutrocytes, acidocytes, histocytes and mast cells are recognized, b) plenty of capillaries exist and fresh reticular granulations are found, and c) destruction of the fundus of the cancer nest and differentiation of the cancer nest are marked, etc. (S. HAMADA)

  13. What is better: cryocautery or electrocautery for cervical erosion?

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    Monika Jindal

    2014-06-01

    Full Text Available Background: Present study was conducted with a background in mind to compare the efficacy of electrocautery and cryocautery for the management of cervical erosion. Aim of this study was to compare the efficacy of electrocautery and cryocautery for the treatment of cervical erosion and to check cost effectiveness. Methods: A comparative study was conducted at Maharishi Markandeshwar medical college and hospital, Kumarhatti (Solan between July'13 to June'14 among 100 patients of reproductive age group with cervical erosion. They were grouped into 2 groups A (Electrocautery and B (Cryocautery and data obtained was analysed by paired t-test. Results: Though in short- term follow-up at 4-6 weeks after cautery, apparently electrocautery was superior to cryocautery in terms of erosion healing rate 92% vs. 76% as P value (0.4557 is not statistically significant, but in long-term follow-up at 12-14 weeks there was no significant difference in erosion healing but electrocautery was cost effective. Conclusions: Both types of cautery were equally good for treatment of cervical erosion in long-term follow-up. But electrocautery occupies less space and there is no chance of gas leakage in electrocautery, so electrocautery is more cost effective. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 715-719

  14. Conservative treatment of cervical pregnancy with selective unilateral uterine artery embolization

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    Tarasevi?ien?, Viktorija; Nadišauskien?, R?ta; Vaicekavi?ius, Edvardas; Simanavi?i?t?, Daiva

    2007-01-01

    Background. Cervical pregnancy is a rare form of ectopic pregnancy, and the most effective method of its treatment is still under investigation. We would like to call attention to selective uterine artery embolization as an effective modern treatment method. Case. A patient with suspected cervical pregnancy and 7-week amenorrhea was admitted to the hospital after unsuccessful use of emergency contraception. Transvaginal ultrasound showed gestational sack located 11 mm from the external cervic...

  15. Postirradiation sarcoma (malignant fibrous histiocytoma) following uterine cervical cancer

    International Nuclear Information System (INIS)

    A case of postirradiation sarcoma, a malignant fibrous histiocytoma, is described. The tumor occurred in the radiation field (the buttock) 8 years after radiation therapy for keratinizing squamous cell carcinoma of the uterine cervix. The 68-year-old female patient with the inital diagnosis of cervical cancer was treated with pelvic irradiation in 1973. She did well after that with no evidence of disease until 1981 when she developed an enlarging mass in the right buttock within the field of the previous radiation therapy. Microscopically, the tumor at biopsy was composed of pleomorphic histiocyte-like cells, spindle-sphaped cells arranged in a storiform pattern and multinucleated giant cells with bizarre nuclei. Cytodiagnostically, two types of cells, fibroblast-like cells ane histiocyte-like cells, were found. And some cells were considered to be transitional forms, intermediate between fibroblast and histiocytes. Multinucleated pleomorphic giant cells were sometimes seen. Ultrastructurally, the same types of cells were confirmed. These cells contained large numbers of rough endoplasmic reticula with dilated lumens, vacuoles, lysosomal structures, and lipid droplets. (author)

  16. A study on prognostic factors of uterine cervical cancer

    International Nuclear Information System (INIS)

    Prognostic factors of cancer of the cervix were studied in 286 cases treated by radiotherapy. The four items started below relating to morphological characteristics and found to be comparatively easy to determine clinically were selected as prognostic factors. The factors are (1) clinical stage, (2) morphology of the uterine cervix, (3) histological type of cancer and (4) radiosensitivity. Each prognostic factor and prognosis indicated in every case by chi-square test (X2 test) a risk rate lower than 0.1%, a significant difference. Furthermore, every prognostic factor was given points according to their grade, and the total points were expressed as a prognostic index. The prognostic index was classified into the mild zone (from 1 to 8 points), the moderate zone (from 9 to 10 points), and the severe zone (from 11 to 18 points), and the five year survival rate of each zone was observed to be 91.5%, 56.1% and 18.9% respectively. Thus, at a risk of less than 0.1%, a significant difference was observed. By setting up the prognostic index, it was possible to estimate the prognosis of every case of cervical carcinoma, which to date had been nearly impossible to estimate by each prognostic factor alone. (author)

  17. Results of irradiation therapy for advanced uterine cervical cancer

    International Nuclear Information System (INIS)

    152 patients with advanced uterine cervical cancer (76 in stage III, 47 in stage IV and 29 in recurrence) were treated at Miyagi Seijinbyo Center in fifteen years (1967-1981). Our standard treatment was a combined therapy of 6 MVX ray whole pelvis irradiation and intracavitary radium irradiation (or simple total hysterectomy) The actuarial 5-year-survival rate was 46.0% in stage III, 9.4% in stage IV and 10.3% in recurrence. In stage III, the actuarial 5-year-survival rate in nine cases with external irradiation alone was (22.2%), in 44 cases with intracavitary irradiation and external irradiation 48.7%; in 14 cases with operation and external irradiation 57.1%. No five year survival was found in nine interrupted-irradation cases. Moderate complications in the rectum and/or the urinary bladder were found in eight of 67 (12%) irradiation-completed patients in stage III. Five 5-year-survival cases (two in stage IV and three in recurrence) were reported. (author)

  18. Electron microscopic studies on radiosensitivity of uterine cervical cancer

    International Nuclear Information System (INIS)

    Forty patients with II or III stage of uterine cervical cancer were given 1000 rads of test irradiation, and radiosensitivity of the tissues was examined electron-microscopically before and 1,3,5 and 7 days after the irradiation. At 24 hours after the irradiation, no changes were observed in the nuclei and the cytoplasm. From 3 days after the irradiation, disturbances of the nuclear membranes (enhancement of sawteeth-like irregularity of the nuclear edge, formation of linear or vacuolar pseudo-enclosures in the nuclei and so on), abnormal distribution of chromatins in the nuclei (agglutination, lightening and so on), enlargement and degeneration of mitochondria, enlargement of endoplasmic reticulum and decrease of ribosomes were observed. These changes were enhanced according to time. In the findings of the cases with good radiosensitivity, marked changes were shown, such as abnormal distribution of chromatins in the nuclei, disturbances of nuclear membranes, decrease of the size of mitochondria, enhancement of electron density of mitochondria, enlargement of endoplasmic reticulum and decrease of ribosomes in the cytoplasm. While in the cases with low radiosensitivity, poor changes were found. Suspected from the findings before the irradiation, small organs in the cells were generally undeveloped, mitochondria were small and few, ribosomes and rude endoplasmic reticulum were poorly found, structure of membrane was weak and intercelluar combination was loose in the cases with good radiosensitivity. Contrariwise, the cases, in which these were fully developed, had poor radiosensitivity in general. (Kanao, N.)

  19. Assessment of Cervical Erosion in Hamedan City, Iran

    OpenAIRE

    Fatemeh Shobeiri; Mansour Nazari

    2007-01-01

    The purpose of this study was to determine the role of socio-economic factors and cytology in cervical erosion. A cross-sectional study involving 410 females in the reproductive age group was conducted in urban health centers in Hamedan city, Iran. Data were collected through interviews with women, gynecological examination in the clinics in the health centers and laboratory tests. Cervical erosion was detected in 68 (16.6%) females. Out of these mild dysplasia was seen in (8.8%) females. Hig...

  20. Is excretory urography necessary in the staging work-up of uterine cervical carcinoma?

    International Nuclear Information System (INIS)

    Excretory urography has been routinely included in the staging work-up of uterine cervical carcinoma in the ear of popular use of computerized tomography (CT). The purpose of this retrospective study was to evaluate the necessity of excretory urography in the staging of uterine cervical carcinoma in addition to the routine CT. In 143 patients with histologically proven uterine cervical carcinoma, we compared excretory urography with CT, in respect to the ability of each study to demonstrated the pelvocalyces and the ureters, the level and the cause of the ureteral obstruction, and the invasion of urinary bladder. The results were as follows: Pelvocalyces and proximal ureters were demonstrated in 95% or more both on excretory urography and on CT, however, middle and distal ureters were demonstrated on CT better than on excretory urography. In 6 patients with ureteral obstruction by the extension of uterine cervical carcinoma, CT was more informative than excretory urography in respect to the level and the cause of the ureteral obstruction. CT was superior to excretory urography to confirm the presence or absence of the bladder invasion. From these results, we suggest that excretory urography can be omitted in the era of routine inclusion of CT in the staging work-up of uterine cervical carcinoma

  1. Role of protease activated receptor-2 in lymph node metastasis of uterine cervical cancers

    International Nuclear Information System (INIS)

    Protease activated receptor-2 (PAR-2) has been implicated in cellular proliferation, invasion and metastasis in various tumors. Lymph node metastasis is an important patient prognostic factor for uterine cervical cancers. This prompted us to study the role of PAR-2 in lymph node metastasis of uterine cervical cancers. Thirty patients underwent surgery for uterine cervical cancers. PAR-2 histoscores and mRNA levels were determined by immunohistochemistry and real-time reverse transcription-polymerase chain reaction, respectively. Patient prognosis was analyzed with a 48-month survival rate. PAR-2 histoscores and mRNA levels significantly (P < 0.05) increased in 12 of 30 metastatic lymph node lesions from the corresponding primary tumor. The 48-month survival rate of the 12 patients with increased PAR-2 levels in metastatic lymph nodes was 42%, while the rate of the other 18 patients with no change in PAR-2 levels was 82%, regardless of histopathological type. PAR-2 might work on lymph node metastasis of uterine cervical cancers, and is considered to be a novel prognostic indicator for uterine cervical cancers

  2. KAMPILLAKADI GHRITA IN GARBHASHAYA GREEVA GATA VRANA (CERVICAL EROSION

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    Dhiman Kamini

    2012-04-01

    Full Text Available Certain diseases may not be life threatening but troublesome and irritating to an individual in day to day routine activity. “Cervical erosion” is one among them increasing day by day and demanding greater concern over it. It is a benign condition but if left untreated may leads up to infertility and predisposes to cervical malignancy. Cauterization is the known treatment for cervical erosion but chances of recurrence of the disease are high. Keeping this fact in mind the present clinical study has been undertaken. The total effect of drug was evaluated on the basis of signs and symptoms after completion of therapy. The data obtained in clinical study before and after treatment was expressed in terms of Mean, Standard Deviation (+SD and Standard Error (+SE. Group-I revealed better results than Group-II over total criteria of assessment.

  3. Electron microscopic study on radiosensitivity of uterine cervical cancer

    International Nuclear Information System (INIS)

    The effects of 1000 R of tele-cobalt upon the changes in the primary lesions of uterine cervical cancer with time were studied with an electron microscope. In addition, twenty cases which were proven to have cancer tissues (10 cases of IInd stage of cancer, 8 cases of IIIrd stage of cancer and 2 cases of IVth stage of cancer) were studied. Four cases were favourably sensitive, 7 cases moderately sensitive and 9 cases unfavourably sensitive to radiation. In favourably radio-sensitive cases, the changes in the cancer cells first appeared in the nucleus. There were other changes such as local clumping of chromatin and, specifically, vacuolization of the nucleus. The changes in the endoplasmic reticulum appeared somewhat late. In addition, the disturbance of mitochondria and the decrease or disappearance of ribosomes were specifically due to radiation injury. From the point of view of changes with time, Golgi's apparatus was enlarged and the membrane of the endoplasmic reticulum was degenerated at the 1st day. At the 3rd day, vacuolization of the nucleus appeared, the nuclear corpuscles were increased, the nucleoplasm became thin, and mitochondria was enlarged and degenerated. At the 5th day, the nuclear membrane disappeared, the nucleus was destroyed, large vacuolization of the endoplasmic reticulum was seen, free ribosomes were decreased, and changes around the endoplasmic reticulum were observed. At the 7th day, collagen around the endoplasmic reticulum appeared. In favourably radiosensitive cases, individual tumor cells showed the same degeneration, which fairly corresponded to that evaluated by the histological observation. The disturbance of the cells was caused by radiation, so-called ''burning'' of the cells. Radiation protection of the cells against burning was considered in terms of their radiosensitivity. (K. SERIZAWA)

  4. Lumber and cervical osseous erosions secondary to herniated disks

    International Nuclear Information System (INIS)

    Only seven cases of lumber vertebral body or lateral recess enlargement have been reported previously in the English-language literature. The authors studied six cases of herniated nucleus pulposus (HNP) that was causing bone erosion. Five were in the lumbar spine, and one was in the cervical spine. All five lumbar HNPs were eroding the osseous contours of the lateral recess (the posterior vertebral body and pedicles). Two of the lumbar disks were sequestered posterolaterally and also were eroding the lamina aggressively. The cervical HNP had resulted in erosion of intervertebral foramen, posterior vertebral body, and pedicle. Myelography, CT, and MR imaging all demonstrated the epidural defect. However, only CT convincingly demonstrated the bone erosion

  5. Super-selective uterine artery chemoembolization for the treatment of cervical cancer: its clinical value

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    Objective: To evaluate super-selective uterine arterial chemoembolization therapy in the treatment of cervical cancer. Methods: Bilateral uterine arterial infusion with DDP, EADM or THP, MMC and 5-Fu was performed in 56 patients with pathologically-proved cervical cancer, which was followed by embolization of uterine arteries with iodine emulsion and Gelfoam particles. Radical hysterectomy was performed in 6 patients after interventional treatment. Results: Embolization of bilateral uterine arteries were successfully carried out in all cases. The angiography conducted during the procedure revealed markedly dilated uterine arteries, spiral tumor-feeding arteries and obvious tumor staining. The total effective rate was up to 94.6%. Six patients received radical hysterectomy 2 weeks after arterial chemoembolization, and the blood loss during the operation was much less than usual and the surgery procedure took shorter time. Ovarian necrosis was found in 1 case. The main adverse effects included leukocytopenia, nausea, vomiting and abdominal pain. Conclusion: Super-selective uterine arterial chemoembolization is a safe and effective supplementary therapy for cervical carcinoma with fewer complications. (authors)

  6. Evaluation of magnetic resonance imaging in the diagnosis of extension in uterine cervical cancer cases

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    To prove the usefulness of magnetic resonance imaging (MRI) in determining the invasion of uterine cervical cancer with imaging planes, we evaluated 44 patients with histologically proved cervical cancer. MRI was performed with a Signa 1.5 T (General Electric), and a T2-weighted image was used. In coronal planes, the accuracy was 75.0% for parametrial invasion. It was impossible to diagnose in 77.8%, 92.1% and 63.2% the invasion of the uterine body, bladder, and rectum, respectively. In axial planes, the accuracy was 76.3%, 92.1% and 78.9% for the invasion of parametrium, bladder and rectum, respectively. It was impossible to diagnose in 72.2% the invasion of the uterine body. In sagittal planes, the accuracy was 80.6%, 97.4% and 89.7% for invasion of the uterine body, bladder and rectum, respectively. In all 39 cases it was impossible to diagnose parametrial invasion. In five cases, MRI failed to detect the tumor in any of the three planes, but in three cases it was able to detect the tumor in at least one of the three. We conclude as follows: MRI is a useful method in determining the invasion of cervical cancer. Coronal planes are recommended for the determination of parametrial invasion, axial planes for the parametrium, bladder and rectum, and sagittal planes for the uterine body, bladder and rectum. All three planes are needed to determine cervical cancer. (author)

  7. Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology

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    Balleyguier, Corinne [Radiology Department, Institut Gustave Roussy, Villejuif (France); Sala, E. [Radiology Department, Addenbrooke' s Hospital, Cambridge (United Kingdom); Cunha, T. da [Radiology Department, Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Lisbon (Portugal); Bergman, A. [Department of Radiology, Uppsala University Hospital (Sweden); Brkljacic, B. [Department of Diagnostic and Interventional Radiology, University Hospital ' ' Dubrava' ' , Zagreb (Croatia); Danza, F. [Dipartimento di Bioimmaginie Scienze Radiologiche, Universita Cattolica del S. Cuore, Rome (Italy); Forstner, R. [Zentralroentgeninstitut, Landeskliniken Salzburg, Salzburg (Austria); Hamm, B. [Department of Radiology, Charite Humboldt Universitaet, Berlin (Germany); Kubik-Huch, R. [Institut Radiologie, Kantonsspital Baden, Baden (Switzerland); Lopez, C.; Manfredi, R. [Department of Radiology, ' ' A. Gemelli' ' University Hospital, Rome (Italy); McHugo, J. [Department of Radiology, Birmingham Women' s Hospital, Birmingham (United Kingdom); Oleaga, L. [Radiology Department, Hospital Clinic, Barcelona (Spain); Togashi, K. [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Graduate School of Medicine, Kyoto (Japan); Kinkel, K. [Institut de Radiologie, Clinique des Grangettes, Geneva (Switzerland)

    2011-05-15

    To design clear guidelines for the staging and follow-up of patients with uterine cervical cancer, and to provide the radiologist with a framework for use in multidisciplinary conferences. Methods: Guidelines for uterine cervical cancer staging and follow-up were defined by the female imaging subcommittee of the ESUR (European Society of Urogenital Radiology) based on the expert consensus of imaging protocols of 11 leading institutions and a critical review of the literature. The results indicated that high field Magnetic Resonance Imaging (MRI) should include at least two T2-weighted sequences in sagittal, axial oblique or coronal oblique orientation (short and long axis of the uterine cervix) of the pelvic content. Axial T1-weighted sequence is useful to detect suspicious pelvic and abdominal lymph nodes, and images from symphysis to the left renal vein are required. The intravenous administration of Gadolinium-chelates is optional but is often required for small lesions (<2 cm) and for follow-up after treatment. Diffusion-weighted sequences are optional but are recommended to help evaluate lymph nodes and to detect a residual lesion after chemoradiotherapy. Expert consensus and literature review lead to an optimized MRI protocol to stage uterine cervical cancer. MRI is the imaging modality of choice for preoperative staging and follow-up in patients with uterine cervical cancer. (orig.)

  8. Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology

    International Nuclear Information System (INIS)

    To design clear guidelines for the staging and follow-up of patients with uterine cervical cancer, and to provide the radiologist with a framework for use in multidisciplinary conferences. Methods: Guidelines for uterine cervical cancer staging and follow-up were defined by the female imaging subcommittee of the ESUR (European Society of Urogenital Radiology) based on the expert consensus of imaging protocols of 11 leading institutions and a critical review of the literature. The results indicated that high field Magnetic Resonance Imaging (MRI) should include at least two T2-weighted sequences in sagittal, axial oblique or coronal oblique orientation (short and long axis of the uterine cervix) of the pelvic content. Axial T1-weighted sequence is useful to detect suspicious pelvic and abdominal lymph nodes, and images from symphysis to the left renal vein are required. The intravenous administration of Gadolinium-chelates is optional but is often required for small lesions (<2 cm) and for follow-up after treatment. Diffusion-weighted sequences are optional but are recommended to help evaluate lymph nodes and to detect a residual lesion after chemoradiotherapy. Expert consensus and literature review lead to an optimized MRI protocol to stage uterine cervical cancer. MRI is the imaging modality of choice for preoperative staging and follow-up in patients with uterine cervical cancer. (orig.)

  9. Variable uterine uptake of FDG in adenomyosis during concurrent chemoradiation therapy for cervical cancer

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    Yu, Jeong Il; Huh, Seung Jae; Kim, Young Il; Kim, Tae Joong; Park, Byung Kwan [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2011-09-15

    To avoid improper tumor volume contouring in radiation therapy (RT) and other invasive procedures, we report a case of uterine adenomyosis showing increased 18F-fl uorodeoxyglucose (FDG) uptake on positron emission tomography (PET)/computed tomography (CT) mimicking malignant tumor in a 44-year-old woman during concurrent chemoradiation therapy (CCRT) for uterine cervical cancer. The adenomyosis was not associated with her menstrual cycle or with normal endometrium uptake, and it resolved one month after completion of RT. This case indicates that uterine adenomyosis in a premenopausal woman may show false positive uptake of 18FDG-PET/CT associated with CCRT.

  10. Role of MRI in detecting involvement of the uterine internal os in uterine cervical cancer: Systematic review of diagnostic test accuracy

    Energy Technology Data Exchange (ETDEWEB)

    Boer, Peter de, E-mail: p.deboer@amc.uva.nl [Department of Radiation Oncology, Academic Medical Centre (AMC), University of Amsterdam (UvA), Meibergdreef 9, 1105 AZ Amsterdam (Netherlands); Adam, Judit A. [Department of Radiology, AMC, UvA (Netherlands); Department of Nuclear Medicine, AMC, UvA (Netherlands); Buist, Marrije R. [Department of Gynaecology and Obstetrics, AMC, UvA (Netherlands); Vijver, Marc J. van de [Department of Pathology, AMC, UvA (Netherlands); Rasch, Coen R. [Department of Radiation Oncology, Academic Medical Centre (AMC), University of Amsterdam (UvA), Meibergdreef 9, 1105 AZ Amsterdam (Netherlands); Stoker, Jaap; Bipat, Shandra [Department of Radiology, AMC, UvA (Netherlands); Stalpers, Lukas J.A. [Department of Radiation Oncology, Academic Medical Centre (AMC), University of Amsterdam (UvA), Meibergdreef 9, 1105 AZ Amsterdam (Netherlands)

    2013-09-15

    Purpose: In patients with uterine cervical cancer, pretreatment recognition of uterine extension is crucial in treatment decision-making for fertility-sparing surgery and for target delineation in radiotherapy. Although MRI is generally considered the most reliable method, its value for detecting involvement of the uterine internal os is unclear. Methods: Medline, Embase and Cochrane databases were systematically searched (January 1997–December 2012) for MRI studies that measured the accuracy of involvement of the uterine internal os compared to histopathology as reference standard in patients with uterine cervical cancer. Data were assessed using the QUADAS tool. Accuracy concerned either involvement (yes/no) of the uterine internal os, or measuring invasion distance toward the uterine corpus. Results: Two retrospective and two prospective studies described 366 patients diagnosed with uterine cervical cancer FIGO stage IIB or below, in whom 64 (17%) had uterine internal os involvement. For three studies the summary estimates of specificity, sensitivity, negative predictive value (NPV), positive predictive value (PPV), and accuracy were 91%, 97%, 99%, 79% and 95%, respectively; one study had an area under the curve (AUC) of 0.8. Conclusion: MRI has a high level of accuracy; however, data are limited and for validation a large prospective study is needed that compares actual measurements on MRI with histopathological examination.

  11. Utility of the broccoli sign in the distinction of prolapsed uterine tumor from cervical tumor

    Energy Technology Data Exchange (ETDEWEB)

    Jha, Priyanka; Chang, Stephanie T. [Department of Radiology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628 (United States); Rabban, Joseph T. [Department of Anatomic Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628 (United States); Chen, Lee-may [Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628 (United States); Yeh, Benjamin M. [Department of Radiology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628 (United States); Coakley, Fergus V., E-mail: Fergus.Coakley@radiology.ucsf.edu [Department of Radiology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628 (United States)

    2012-08-15

    Objective: To describe the utility, histopathological basis, and clinical correlates of the broccoli sign. Methods: The committee on human research approved this HIPAA compliant study and waived written informed consent. Based on the records of the senior author and our multidisciplinary Gynecologic Oncology Tumor Board, we retrospectively identified thirteen women (mean age of 48.8 years; range, 34-74) with a cervical mass seen at MR imaging (n = 13) or CT (n = 5) that demonstrated the previously reported broccoli sign (i.e., a soft tissue stalk connecting the cervical mass to the uterine cavity) on one or other modality. All available clinical, imaging, and histopathological records were reviewed, with particular emphasis on initially suspected diagnosis, final proven diagnosis, and outcome. Results: Cervical cancer was the initial clinically suspected diagnosis in 6 of 13 patients. Surgical resection demonstrated prolapsed uterine tumor in all patients, consisting of endometrioid adenocarcinoma (n = 7), carcinosarcoma (n = 2), adenosarcoma (n = 1), and leiomyoma (n = 3). Excluding the three patients with leiomyomas, currently, 7 patients with malignant tumors are disease free after a mean interval of 15 months (range, 3-45) and 3 patients have been lost to follow-up. Conclusion: A stalk connecting an apparent cervical mass seen at CT or MR imaging to the endometrial cavity ('broccoli sign') favors the diagnosis of a prolapsed uterine tumor; these prolapsed uterine tumors can often be malignant but appear to have a good prognosis.

  12. A randomised comparison of two brachytherapy devices for the treatment of uterine cervical carcinoma

    International Nuclear Information System (INIS)

    Two brachytherapy applicators commonly used in the treatment of uterine cervical carcinoma, the Henschke shielded and Fletcher-Suit-Declos, were randomly and prospectively compared in vivo in 20 patients. Based on two-dimensional planning and the ICRU-38 bladder and rectal reference points, an advantage for the shielded Henschke applicator was demonstrated

  13. Primary cervical and uterine corpus lymphoma; a case report and literature review.

    Czech Academy of Sciences Publication Activity Database

    Anagnostopoulos, A.; Mouzakiti, N.; Ruthven, S.; Herod, J.; Kotsyfakis, Michalis

    2013-01-01

    Ro?. 6, ?. 4 (2013), s. 298-306. ISSN 1940-5901 R&D Projects: GA ?R GAP502/12/2409 Institutional support: RVO:60077344 Keywords : Non-Hodgkin's lymphoma * extra-nodal lymphoma * uterine/cervical lymphoma Subject RIV: EC - Immunology Impact factor: 1.422, year: 2013

  14. Utility of the broccoli sign in the distinction of prolapsed uterine tumor from cervical tumor

    International Nuclear Information System (INIS)

    Objective: To describe the utility, histopathological basis, and clinical correlates of the broccoli sign. Methods: The committee on human research approved this HIPAA compliant study and waived written informed consent. Based on the records of the senior author and our multidisciplinary Gynecologic Oncology Tumor Board, we retrospectively identified thirteen women (mean age of 48.8 years; range, 34–74) with a cervical mass seen at MR imaging (n = 13) or CT (n = 5) that demonstrated the previously reported broccoli sign (i.e., a soft tissue stalk connecting the cervical mass to the uterine cavity) on one or other modality. All available clinical, imaging, and histopathological records were reviewed, with particular emphasis on initially suspected diagnosis, final proven diagnosis, and outcome. Results: Cervical cancer was the initial clinically suspected diagnosis in 6 of 13 patients. Surgical resection demonstrated prolapsed uterine tumor in all patients, consisting of endometrioid adenocarcinoma (n = 7), carcinosarcoma (n = 2), adenosarcoma (n = 1), and leiomyoma (n = 3). Excluding the three patients with leiomyomas, currently, 7 patients with malignant tumors are disease free after a mean interval of 15 months (range, 3–45) and 3 patients have been lost to follow-up. Conclusion: A stalk connecting an apparent cervical mass seen at CT or MR imaging to the endometrial cavity (“broccoli sign”) favors the diagnosis of a prolapsed uterine tumor; these prolapsed uterine tumors can often be malignant but appear to have a good prognosis.

  15. Fractionated high-dose-rate brachytherapy in the management of uterine cervical cancer.

    Science.gov (United States)

    Park, Hee-Chul; Suh, Chang Ok; Kim, Gwi Eon

    2002-12-01

    It is well known that intracavitary radiotherapy (ICR), either alone or in combination with external-beam radiotherapy (EBRT) is an essential component of the radiation treatment of uterine cervical cancer. Although low-dose-rate (LDR) brachytherapy has been successfully applied to the management of such patients, several radiation oncologists have experience of using high-dose-rate (HDR) brachytherapy with promising clinical results over the past 4 decades. However, there has been a considerable reluctance by radiation oncologists and gynecologists in North America to employ the HDR remote afterloading technique instead of the more firmly established LDR treatment modality. In contrast, the HDR-ICR system is rapidly gaining acceptance in Korea since the introduction of the Ralstron, remotely controlled afterloading system using HDR Co-60 sources, at the Yonsei Cancer Center in 1979. According to brachytherapy statistics reported by the Korean Society of Therapeutic Radiology and Oncology, in 1997, brachytherapy was performed upon 1,758 Korean patients with uterine cervical cancer, of whom approximately 83% received HDR brachytherapy. In this review, we present our experiences of HDR-ICR for the treatment of uterine cervical cancer. In addition, we discuss the controversial points, which are raised by those considering the use of HDR-ICR for uterine cervical cancer; these issues include physical and radiobiological considerations, and the prospect of future technical improvements. PMID:12497657

  16. Diagnosis of recurrent uterine cervical cancer: computed tomography versus positron emission tomography

    International Nuclear Information System (INIS)

    To determine the accuracy of CT and positron emission tomography (PET) in the diagnosis of recurrent uterine cervical cancer. Imaging findings of CT and PET in 36 patients (mean age, 53 years) in whom recurrent uterine cervical cancer was suspected were analyzed retrospectively. Between October 1997 and May 1998, they had undergone surgery and/or radiation therapy. Tumor recurrence was confirmed by pathologic examination or follow-up studies. In detecting recurrent uterine cervical cancer, the sensitivity, specificity, and accuracy of CT were 77.8%, 83.3%, and 80.5%, respectively, while for PET, the corresponding figures were 100%, 94.4%, and 97.2%. The Chi-square test revealed no significant difference in specificity (p= .2888), but significant differences in sensitivity (p= .0339) and accuracy (p= .0244). PET proved to be a reliable screening method for detecting recurrent uterine cervical cancer, but to determine the anatomical localization of recurrent tumors, and thus decide an adequate treatment plan, CT was eventually needed

  17. Value of intramuscular methotrexate and bilateral uterine artery embolization for treating cervical ectopic pregnancy

    International Nuclear Information System (INIS)

    Objective: To assess the clinical value of bilateral uterine artery chemotherapy embolization (UACE) for cervical ectopic pregnancy analyzed. Methods: Clinical records of 40 patients with cervical ectopic pregnancy treated using UACE were retrospectively analyzed. Results: 8 patients with severe active vaginal bleeding after curettage were treated urgently with UACE. The remaining 32 patients were treated with UACE combined with sequential ultrasound-guided curettage. Active vaginal bleeding was stopped after UACE. There was no recurrent hemorrhage with the sequential ultrasound-guided curettage procedure. The ?-HCG levels of all patients were normalized after 1 month. Conclusion: Bilateral uterine artery chemotherapy embolization is valuable as emergency treatment for patients with severe vaginal bleeding from cervical ectopic pregnancy. UACE combined with sequential ultrasound-guided curettage may be more effective. (authors)

  18. Superselective uterine artery chemoembolization for the treatment of cervical cancer: a clinical analysis of 33 cases

    International Nuclear Information System (INIS)

    Objective: To discuss the clinical therapeutic effect and side reaction of superselective uterine arterial chemoembolization therapy for the treatment of cervical cancer. Methods: Bilateral uterine arterial chemoembolization was performed in 33 patients with pathologically-proved cervical cancer. The infusion drugs included DDP or L-OHP, EADM, MMC and 5-Fu. The Gelfoam particle was employed as embolic agent. The therapeutic effect evaluated by observing the improvement of clinical symptoms and the volume reduction of the tumor. Results: Of the total 33 patients with pathologically-confirmed cervical cancer, squamous cell carcinoma was seen in 29 and adenocarcinoma in 4. Based on FIGO classification (established by Federation International of Gynecology and Obstetrics), 6, 23 and 4 patients were classified in stage ?, ? and ? respectively. The angiography conducted during the procedure showed that the uterine arteries were markedly dilated, and spiral tumor-feeding arteries as well as tumor stain were also observed. Technical success together with perfect chemoembolization was achieved for 57 uterine arteries in 33 patients. Among the 33 patients, the interventional treatment was carried out three times in 2, two times in 2 and single time in 29. One week after the initial interventional procedure the remission rate of the clinical symptoms was 96% for squamous cell carcinoma and 100% for adenocarcinoma. One month after the treatment, the mean tumor volume was decreased by 30%, the tumor volume reduction for squamous cell carcinoma was 27.6% and was 50.0% for adenocarcinoma. Surgical resection after interventional therapy was carried out in 21 cases and additional radiotherapy after surgery or interventional procedure was adopted in 11 cases. The main adverse reactions after interventional procedure included fever, leucocytopenia, nausea, vomiting, abdominal pain, etc. Conclusion: Superselective uterine arterial chemoembolization is one of effective supplementary measures for the comprehensive treatment of cervical carcinoma. (authors)

  19. Assessment of parturition with cervical light-induced fluorescence and uterine electromyography.

    Science.gov (United States)

    Lucovnik, Miha; Kuon, Ruben J; Garfield, Robert E

    2013-01-01

    Parturition involves increasing compliance (ripening) of the uterine cervix and activation of the myometrium. These processes take place in a different time frame. Softening and shortening of the cervix starts in midpregnancy, while myometrial activation occurs relatively close to delivery. Methods currently available to clinicians to assess cervical and myometrial changes are subjective and inaccurate, which often causes misjudgments with potentially adverse consequences. The inability to reliably diagnose true preterm labor leads to unnecessary treatments, missed opportunities to improve neonatal outcome, and inherently biased research of treatments. At term, the likelihood of cesarean delivery depends on labor management, which in turn depends on accurate assessments of cervical change and myometrial contractility. Studies from our group and others show that noninvasive measurements of light-induced fluorescence (LIF) of cervical collagen and uterine electromyography (EMG) objectively detect changes in the composition of the cervix and myometrial preparedness to labor and are more reliable than clinical observations alone. We present a conceptual model of parturition constructed on cervical LIF and uterine EMG studies. We also explore how these methodologies could be helpful with managing patients experiencing preterm contractions and with optimizing labor management protocols aimed to reduce cesarean section. PMID:24187578

  20. Uterine cervical cancer. Usefulness of MR imaging after the initial radiation therapy

    International Nuclear Information System (INIS)

    To evaluate the usefulness of magnetic resonance imaging (MRI) in diagnosing residual or recurrent tumors of cervical cancer after radiation therapy, we investigated the time difference between MRI and gynecologic findings in the diagnosis of residual or recurrent tumor in 12 patients with invasive cervical cancer. We defined a positive finding for residual or recurrent tumor as an uterine cervical mass isointense to muscle on T1-weighted images and hyperintense on T2-weighted images, and when a positive biopsy specimen was obtained. Two patients were diagnosed as having a residual or recurrent tumor by MRI. Positivity was demonstrated four and seven months later, respectively. MRI was more useful in the earlier diagnosis of residual or recurrent tumor of cervical cancer after radiation therapy than uterine biopsy. There was one patient whose differentiation from residual tumor or radiation-induced necrosis or inflammation on MRI was difficult. MRI and gynecologic check-up at a regular interval after radiation therapy was needed to distinguish them. One patient was diagnosed as having a recurrent tumor by gynecologic finding three months earlier than by MRI. Follow-up MRI examinations at a regular interval in addition to gynecologic examination is necessary for the early detection of recurrent cervical cancer after radiation therapy. (author)

  1. Cerebellar metastases in patients with uterine cervical cancer. Two cases reports and review of the literature

    International Nuclear Information System (INIS)

    Brain metastases from cervical cancer are extremely rare. We report on two patients who developed cerebellar metastases following uterine cervical cancer. The interval between diagnosis of the primary cancer and diagnosis of brain metastasis was 8 months. The main complaint was symptoms of increased intracranial pressure and cerebellar syndrome. Surgical excision of the brain lesion followed by radiation therapy was performed in the first case. The second patient received palliative radiation therapy. The first patient died 8 months after diagnosis. The second patient is alive 2 months after diagnosis. (authors)

  2. Assessment of Parturition with Cervical Light-Induced Fluorescence and Uterine Electromyography

    OpenAIRE

    Miha Lucovnik; KUON, RUBEN J.; GARFIELD, ROBERT E.

    2013-01-01

    Parturition involves increasing compliance (ripening) of the uterine cervix and activation of the myometrium. These processes take place in a different time frame. Softening and shortening of the cervix starts in midpregnancy, while myometrial activation occurs relatively close to delivery. Methods currently available to clinicians to assess cervical and myometrial changes are subjective and inaccurate, which often causes misjudgments with potentially adverse consequences. The inability to re...

  3. Therapeutic effect of intra-arterial chemotherapy with DDP and 5-FU via bilateral uterine arteries for advanced uterine cervical cancer

    International Nuclear Information System (INIS)

    Objective: To evaluate the therapeutic effect of intra-arterial chemotherapy with Ddp and 5-Fu via bilateral uterine arteries for advanced uterine cervical cancer. Methods: During the period of Jan. 2006-Jan. 2009, initial intra-arterial chemotherapy by using a combination of Ddp and 5-Fu via bilateral uterine arteries was performed in 72 patients (mean age 42.9 years) with advanced uterine cervical caner. Of 72 patients, stage I b2 cervical cancer was confirmed in 28, stage II a in 12 and stage II b in 32. Pathologically, cervical squamous cell carcinoma was seen in 56 and cervical adenocarcinoma in 16 patients. Ultrasonography and physical examination were conducted both before and after intra-arterial chemotherapy. The therapeutic results,complications,the surgical resection rate and the pathologic findings were observed and statistically analyzed. Results: Fifty-four patients received one treatment course and 18 patients received two treatment courses. The over all response rate was 77.8%. The response rates of patients with I b2, II a and II b cervical cancer were 92.9%, 83.3% and 62.5% respectively, the difference between three groups was statistically significant (P < 0.05). And the response rates of patients with squamous cell carcinoma and adenocarcinoma were 85.7% and 50.0% respectively, the difference between the two was statistically significant (P < 0.05). The most common side-effects included gastrointestinal symptoms and bone marrow suppression. Thirty-four patients received radical hysterectomy,among them, 22 (78.6%) had stage I b2, 8 (66.7%) had stage II a and 4 (12.5%) had stage II b cervical cancer (P < 0.05). Pathologic exam found no vaginal invasion and ovarian metastasis in all 34 patients. The occurrence of metastasis to lymph nodes and para uterine infiltration were 17.6% and 11.8% respectively. Conclusion: Intra-arterial chemotherapy with a combination of DDP and 5-Fu via bilateral uterine arteries can safely and effectively reduce the tumor volume of advanced cervical cancer, suppress the lymph node metastasis and parametrial infiltration, which is very helpful for creating favorable condition required by the surgery and for reducing the manipulative difficulties of radical hysterectomy. Intra-arterial chemotherapy has better effect on stage Ib2 cervical cancer than on stage II a and II b, and it is quite the same that intraarterial chemotherapy is more effective for cervical squamous cell carcinoma than for adenocarcinoma. (authors)

  4. Knowledge, attitudes and practices about uterine cervical cytology by women of a rural population in Colombia

    Directory of Open Access Journals (Sweden)

    Barrios-García Lía

    2013-06-01

    Full Text Available Introduction: There is concerned in Latin America due to the little or no impact that have had prevention programs in the reduction of cases of uterine cervical neoplasm. Different aspects should be looked at and analyzed.Objective: To determine the knowledge, practice and attitude of women from themunicipality of Pinillos, Colombia, relating to the use of uterine cervical cytology asdiagnostic techniques of early lesions of uterine cervix that entail uterine cervicalneoplasm.Methods: Descriptive study carried out in Pinillos, Bolívar, Colombia. A survey was filledout by 260 women who had had sexual life.Results: 85.4% of the polled patients know what an uterine cervical cytology is.Practically all the polled women know what the usefulness of cytology is. 99.6%recognizes that cytology is important. 88.5% has done the cytology during her life, witha median of 4 done cytologies.Conclusions: The ignorance, the lack of practice and the bad attitude towards therealization of the cytology are not the main causes of that uterine cervical neoplasm hadnot diminished. Rev.cienc.biomed. 2013;4(1:54-59RESUMENIntroducción: existe preocupación en América Latina por el poco o ningún impacto enreducción de casos, que han tenido los programas de prevención del cáncer del cuellouterino. Diferentes aspectos se deben analizar.Objetivo: determinar el conocimiento, práctica y actitud de las mujeres del municipiode Pinillos, Colombia, sobre el uso de la citología cérvico-uterina como método dediagnóstico de las lesiones tempranas del cuello uterino, que conlleven al cáncer decérvix.Metodología: estudio descriptivo realizado en el municipio de Pinillos, Bolívar, Colombia.Se realizó una encuesta a 260 mujeres que habían tenido vida sexual.Resultados: el 85.4% de las pacientes encuestadas saben que es la citología cérvicouterina.Prácticamente todas las mujeres encuestadas saben para qué sirve la citología.El 99.6% reconoce que realizarse la citología es importante. El 88.5% si se ha realizadola citología durante su vida, con una mediana de 4 citologías realizadas.Conclusiones: el desconocimiento, la falta de práctica y la mala actitud hacia larealización de la citología no es la principal causa que el cáncer de cérvix no hayadisminuido. Rev.cienc.biomed. 2013;4(1:54-59

  5. Intracavitary radiotherapy with Cf-252 for uterine cervical carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Fukuda, Koichi (Japanese Foundation for Cancer Research, Tokyo. Hospital)

    1984-02-01

    Cf-252 intracavitary radiotherapy using a remote afterloading system was performed in patients with Stage IIb, IIIb cervical carcinoma. Compared to the control group which was treated with Co-60 high-dose intracavitary radiotherapy, Cf-252 was less effective for squamous cell carcinoma and slightly effective for adenocarcinomas. Recto-sigmoidal injury was frequent in the Cf-252 group so that further study of the Cf-252 effect on the recto-sigmoidal mucosa is required.

  6. Lumboaortic irradiation in uterine cervical cancer: Analysis of the literature

    International Nuclear Information System (INIS)

    Background: Uterine cancer is a prevalent disease in Chile and it is one of the most frequent cancer locations treated in the National Chilean Cancer Institute. It is also common to receive young patients that have advanced tumors in stages IIB and IIIB with high risks of compromises of lymphatic nodes of pelvis and aortic-lumbar zones. The treatment for these kinds of cancers is radio-chemotherapy. Aims: Determinate if the radiotherapy of aortic-lumbar lymph nodes lowers the chance of relapsing or increase the survival rate in patients with evident compromise of aortic-lumbar lymph nodes and in those with high risk of compromise in that level. Method: Exhaustive analysis of the literature about the indication of radiotherapy of aortic-lumbar lymph nodes in cervix cancer which is classified in those where the radiotherapy treatment is done in patients with evident compromise of aortic-lumbar lymph-nodes, and those where de radiotherapy is done in patients with high risk of compromise in that level. Results: In patients with small cervix tumors and positive lymphoid nodes the LA lymphatic nodes treatment would be beneficial. However, patients that suffer massive pelvic disease (IIIB) or that have evidence of the disease, the benefit would not be so important. Conclusion: Patients with controllable pelvic disease and with high risk of having aortic-lumbar lymph nodes compromise are the most benefit of radiotherapy in aortic-lumbar lymph nodes (stages IA-B, IIA-B with positive lymph nodes)

  7. Low-cost technology for screening uterine cervical cancer

    Directory of Open Access Journals (Sweden)

    Aditya Parashari

    2000-08-01

    Full Text Available We report on an illuminated, low-cost (Rs 1500 (US$ 36 magnifying device (Magnivisualizer for detecting precancerous lesions of the uterine cervix. A total of 403 women attending a maternal and child health care clinic who had abnormal vaginal discharge and related symptoms were referred for detailed pelvic examination and visual inspection by means of the device after the application of 5% (v/v acetic acid. Pap smears were obtained at the same time. The results were compared with those obtained using colposcopy and/or histology. The Magnivisualizer improved the detection rate of early cancerous lesions from 60%, for unaided visual inspection, to 95%. It also permitted detection of 58% of cases of low-grade dysplasia and 83% of cases of high-grade dysplasia; none of these cases were detectable by unaided visual inspection. For low-grade dysplasia the sensitivity of detection by means of the Magnivisualizer was 57.5%, in contrast with 75.3% for cytological examination. However, the two methodologies had similar sensitivities for higher grades of lesions. The specificity of screening with the Magnivisualizer was 94.3%, while that of cytology was 99%. The cost per screening was approximately US$ 0.55 for the Magnivisualizer and US$ 1.10 for cytology.

  8. Incidencia y mortalidad por cáncer cervicouterino / Incidence and mortality due to cervical uterine cancer

    Scientific Electronic Library Online (English)

    Yesika Isabel, Reyes Zuñiga; José Guillermo, Sanabria Negrín; Raydel, Marrero Fernández.

    2014-10-01

    Full Text Available Introducción: existe un desconocimiento del impacto del Programa de Detección Precoz del cáncer cervicouterino en el área de salud del policlínico Pedro Borrás Astorga. Objetivo: evaluar el impacto del Programa de Detección Precoz del Cáncer Cervicouterino en el área de salud del Policlínico Univers [...] itario "Pedro Borrás Astorga", Pinar del Río, 2004-2011. Material y método: se realizó una investigación observacional, descriptiva y retrospectiva, utilizando la base automatizada de datos de la Consulta Provincial de Patología de Cuello, del Registro Provincial de Cáncer y del Registro de Mortalidad de la provincia y el área de salud del Policlínico Universitario "Pedro Borrás Astorga" de Pinar del Río en el período considerado, y la Oficina Municipal de Estadísticas para año en particular. Se determinó la tasa de incidencia anual de lesiones en general, específicas por severidad y por grupos de edades, así como la frecuencia de muertes por esta causa. Resultados: el mayor número frecuencias de lesiones cervicales diagnosticadas fue detectado en el año 2010 (72 mujeres), la mayor frecuencia correspondió a neoplasias intraepiteliales cervicales grado I (de bajo grado) (203 NIC I). A medida que aumentaba el grado de severidad de las lesiones se observaba una disminución de las frecuencias y por tanto de las tasas de incidencias promedio anuales. La mortalidad por cáncer cervicouterino fue escasa. Conclusiones: incremento de las lesiones premalignas y de las tasas de incidencia anuales. Incremento de las lesiones premalignas en mujeres jóvenes (menores de 35 años) con respecto a las de 35 años y más. Incremento del carcinoma in situ en el tiempo. Tendencia decreciente de los casos de carcinomas invasores de cuello uterino y de la mortalidad por cáncer cervicouterino. Abstract in english Introduction: there is lack of knowledge about the impact of the Cervical Uterine Cancer Early Screening Program in the health area of Pedro Borrás Astorga University Outpatient Polyclinic. Objective: to evaluate the impact of the Cervical Uterine Cancer Early Screening Program in the health area of [...] Pedro Borrás Astorga University Outpatient Polyclinic, Pinar del Río, years 2004-2011. Material and method: an observation, retrospective and descriptive research was carried out, using the automatized database of the Provincial Medical Office of Cervical Pathology, from the Provincial Records of Cancer and the Province Mortality Records and the health area of Pedro Borrás Astorga University Outpatient Polyclinic in the considered period, and the Province Office of Statistics for a particular year. The annual incidence rate of lesions was determined, specifically by severity and age groups, and also the mortality rate for this cause. Results: the highest number of frequencies of cervical lesions diagnosed was detected in the year 2010 (72 women), the highest frequency corresponded to cervical intraepithelial neoplasias in stage I (low stage) (203 CIN I). The higher the lesions' degree of severity, the lower the frequencies, and thus the annual incidence rates. Mortality for cervical uterine cancer was acarce. Conclusions: increase in the number of premalignant lesions and the annual incidence rates. Increase in the number of premalignant lesions in young women (under 35 years of age) in comparison to those at age 35 or older. Increase in the number of in situ carcinoma within the time period. There was a decreasing tendency in the cases of invading cervical uterine carcinomata and the mortality for cervical uterine cancer.

  9. Problems on the treatment of the uterine cervical cancer

    International Nuclear Information System (INIS)

    The 5 year survival rate of cervical cancer in Japan is 86% in Stage I, 67% in stage II, 37% in Stage III, and 12% in Stage IV separately. In the early cancer as Stage 0 and Stage Ia even 100% and 93% survival rates can be achieved, so in this group, reduction operation for function reservation is recommended. On the other hand in the advanced cancer, the result of the treatment is unsatisfied yet, and better therapy must be considered. This report discuss the effect and the limit of operation therapy and postoperative radiotherapy, as well as the prognosis and side-effect of the radiotherpy in the viewpoint of the doses. (author)

  10. Pelvic insufficiency fracture after definitive radiotherapy for uterine cervical cancer. Retrospective analysis of risk factors

    International Nuclear Information System (INIS)

    The purpose of this study is to determine the incidence, clinical characteristics and risk factors of postradiation pelvic insufficiency fracture (PIF) in women with uterine cervical cancer. We reviewed the medical records of 126 patients who received definitive radiotherapy (RT) for uterine cervical cancer between 2003 and 2009 at our institution. Among them, 99 patients who underwent at least one computed tomography (CT) or magnetic resonance imaging of the pelvis during their follow-up at more than 6 months were included in this analysis. The relationship between the incidence of PIF and several patient- and treatment-related factors was analyzed. The median follow-up period was 21 months. Of the 126 patients, 33 (with a total of 50 lesions) were diagnosed with PIF. The 2-year cumulative incidence was 32%. Univariate analysis showed that age ?70 years (P= 0.0010), postmenopausal state (P = 0.0013), and lower CT density of bone and bone marrow (P = 0.020) significantly related to PIF. In a multivariate analysis, of the 59 patients whose CT densities were evaluable, lower CT density was the only significant factor associated with PIF (P = 0.0026). In conclusion, postradiation PIFs were detected in a considerable number of patients after definitive RT for cervical cancer. Predisposing factors were older age, postmenopausal state, and decreased density of bone and bone marrow on CT. (author)

  11. Staging uterine cervical carcinoma with low-field MR imaging

    International Nuclear Information System (INIS)

    To assess the validity of low-field MR in staging cervical cancer compared to clinical staging. Material and Methods: A total of 95 women entered the study over a 3-year period. MR examinations with a 0.1 T resistive magnet using a body coil and clinical staging according to the FIGO recommendations were performed within 2 weeks from clinical diagnosis. T1- and T2-weighted sequences were obtained in transversal and sagittal acquisitions, and an additional T1 before and after contrast (randomisation to 0.1 or 0.3 mmol/kg b.w. gadodiamide). Treatment decisions on surgery or radiation therapy were made solely on the clinical staging. Results: Sixty-one patients were found to be eligible for surgery. In 5 women, the pathological results revealed a more advanced stage of the disease than assessed by clinical staging. MR correctly staged 4 of the 5 but otherwise tended to overstate the disease. Contrast enhancement significantly reduced this trend (p<0.05) regardless of the contrast medium dose used. Divided into two groups, an operable (less than stage 2b) and an inoperable group (more than stage 2a), the clinical staging correctly classified 57 patients (accuracy 92%) compared to 52 patients with MR using contrast enhancement (accuracy 84%). The specificity was no higher than 31%, whereas the reproducibility of the MR assessment was fairly good with kappa values around 0.65 for both intra- and interobserver variations. Conclusion: In the present set-up, clinical assessment was superior to low-field MR in staging cervical cancer. When using contrast enhancement, the staging accuracies of low-field MR were comparable to the ones reported for techniques with higher tesla values, whereas the specificity and reproducibility errors were lower. The method, therefore, needs to be optimised

  12. Results of Radiotherapy for the Uterine Cervical Cancer

    International Nuclear Information System (INIS)

    One hundred fifty-four patients with the carcinoma of the uterine cervix were studied retrospectively to assess the result and impact of treatment at Department of Radiation Oncology, Korea University, Hae-Wha Hospital from Feb 1981 through Dec. 1986. Prior to radiotherapy, the patients were evaluated and staged by recommendation of FIGO including physical examination, pelvic examination, cystoscopy, rectosigmoidoscopy, chest X-ray, IVP, Ba enema. Also, an additional pelvic CT scan was obtained for some of the patients. The patients were treated by radiotherapy alone or adjuvant postoperative irradiation; In case of radiation therapy only, whole pelvic irradiation was given with C0-69 teletherapy unit via AP and PA parallel opposing fields or 4-oblique fields, 180 cGy per day, 5 days per week and intracavitary insertion was performed. Three dimensional quantitative demonstration of tumor volume is also important in planning radiation therapy. Another advantage of CT scan was detection of recurrent tumor after radiation or surgery. Local control rate of tumor according to the size was 91.3% for less than 5 cm in size and 44.6% in tumor over 5 cm (p<0.0068). Thirty out of 50 recurrent sites has locoregional failures and 17 cases has distant metastases. And the papa-aortic lymph nodes were the most common site for distant metastases. The most common complication was temporal rectal bleeding which was controlled most by conservative management. However, 4 patients required for endoscopic cauterization. The 5-year survival rates showed; stage la and lb 95%, stage lla 81% stage llb 67%, stage llla 37.7%, stage lllb 23%, and 3-year survival rate of stage lVa showed 11.6%, retrospectively

  13. Clinical outcomes of adjuvant radiation therapy and prognostic factors in early stage uterine cervical cancer

    International Nuclear Information System (INIS)

    To evaluate the outcomes of adjuvant radiotherapy (RT) and to analyze prognostic factors of survival in the International Federation of Gynecology and Obstetrics (FIGO) IB-IIA uterine cervical cancer. We retrospectively reviewed the medical records of 148 patients with FIGO IB-IIA uterine cervical cancer who underwent surgery followed by adjuvant RT at the Yonsei Cancer Center between June 1997 and December 2011. Adjuvant radiotherapy was delivered to the whole pelvis or an extended field with or without brachytherapy. Among all patients, 57 (38.5%) received adjuvant chemotherapy either concurrently or sequentially. To analyze prognostic factors, we assessed clinicopathologic variables and metabolic parameters measured on preoperative 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). To evaluate the predictive performance of metabolic parameters, receiver operating characteristic curve analysis was used. Overall survival (OS) and disease-free survival (DFS) were analyzed by the Kaplan-Meier method. The median follow-up period was 63.2 months (range, 2.7 to 206.8 months). Locoregional recurrence alone occurred in 6 patients, while distant metastasis was present in 16 patients, including 2 patients with simultaneous regional failure. The 5-year and 10-year OSs were 87.0% and 85.4%, respectively. The 5-year and 10-year DFSs were 83.8% and 82.5%, respectively. In multivariate analysis, pathologic type and tumor size were shown to be significant prognostic factors associated with both DFS and OS. In subset analysis of 40 patients who underwent preoperative PET/CT, total lesion glycolysis was shown to be the most significant prognostic factor among the clinicopathologic variables and metabolic parameters for DFS. Our results demonstrated that adjuvant RT following hysterectomy effectively improves local control. From the subset analysis of preoperative PET/CT, we can consider that metabolic parameters may hold prognostic significance in early uterine cervical cancer patients. More effective systemic treatments might be needed to reduce distant metastasis in these patients

  14. Minimally Invasive Surgery: A New Approach for Uterine Cervical Cancer

    Directory of Open Access Journals (Sweden)

    Mihaela M?d?lina Gavrilescu

    2015-07-01

    Full Text Available Initially used for diagnostic, laparoscopy has become a method of treatment in the field of gynecological surgery, but also in many other fields. The results of laparoscopic surgery are now comparable with those obtained by laparotomy in benign and malignant pathologies. Laparoscopy provides improved results in the short term and at least equivalent results in terms of long-term recurrence when compared with open surgery. Robotic-assisted laparoscopy was performed to prevent the disadvantages of conventional laparoscopy. It emerged as a revolutionary technology and has spread in less than a decade in many surgical fields, including urology, cardiothoracic surgery, pediatric surgery and general surgery. Minimally invasive techniques provide a lower rate of complications during surgery as compared to open surgery, which is appropriate tissue due to handling and better anatomical views. Laparoscopic treatment of cervical cancer provides benefits on increasing comfort with decreased convalescence time, but these cases should be reserved for surgeons with extensive experience in laparoscopic procedures. One of the most important advantages of minimally invasive surgical techniques is the short duration of hospitalization.

  15. Usage of CT and tumor markers in the management of a patient with cervical cancer after colpocleisis for uterine prolapse

    International Nuclear Information System (INIS)

    A 79-year-old woman developed stage IIIb cervical carcinoma 13 years after colpocleisis for uterine prolapse. The patient was treated with external irradiation of 60 Gy and chemotherapy with 5-FU (100 mg/day) and Ok-432. The response of tumor could be monitored by serial changes in tumor markers, such as SCC, IAP, TPA, CEA, LDH, and ALP, and CT findings. Considering that colpocleisis makes it impossible to visualize the uterine cervix, the adequate selection of surgical procedure for uterine prolapse is required. (Namekawa, K.)

  16. Significance of total hysterectomy for uterine cervical cancer persistent in the uterine cervix after radiotherapy

    International Nuclear Information System (INIS)

    Radiation therapy is an important means for treating advanced cases of cervical cancer. There are cases, however, in which cancer cells persist even after treatment has been completed. We in the Department of Gynecology at the Cancer Institute Hospital actively performed total hysterectomies in such patients with no distant metastases and no extension of the parametrial induration to the pelvic wall, and obtained favorable results. In the present study, the clinical stage, histological type, degree of removal of involved tissue, and relationship between the prognosis and the maximum diameter of the tumor in the extirpated uterus were examined in 28 patients with advanced cervical cancer treated during the thirty-year period from 1957 to 1986. The following results were obtained: 1. The clinical stage and histological type of the cancer prior to radiation therapy did not significantly affect the prognosis after total hysterectomy. 2. The 3-year survival rate for the patients in whom all involved tissue could be removed was 81.0 percent. In contrast, all those in whom complete removal was impossible survived less than 3 years, despite additional therapy. 3. Prognosis was better in the patients who had tumors with a maximum diameter of less than 2 cm than in those who had tumors with a maximum diameter of 2 cm or more (p < 0.05). 4. Patients in whom all involved tissue could be removed and in whom the maximum diameter of the tumor was less than 2 cm had a good prognoses, with 88.9 percent surviving at least 3 years after surgery. (author)

  17. Biological properties and radiation responses of the hamster uterine cervical squamous cell carcinoma

    International Nuclear Information System (INIS)

    Results of initial studies of the growth characteristics, immunogenicity, histopathology, and radiation response of a uterine cervical squamous cell carcinoma of the Syrian hamster are presented. The cervical carcinoma is a relatively loosely knit, undifferentiated, highly cellular tumor without a recognizable architectural pattern but with a gradation in cellular density decreasing from the perimeter to the center of the tumor. The vascular network corresponds with the histologic features such that radially arranged capillaries join a dilated, tortuous network at the perimeter and with a sparse network in the center of the tumor. Tests of the immunogenicity of the cervical carcinoma by either suppressing the immune mechanism(s) or sensitizing the animal to the tumor indicate that this tumor provides little or no stimulus to the host immunologic system. After radiation exposures ranging from 1000 to 7000 R, tumor volume in persisting tumors shows a pattern of retardation and/or regression followed by regrowth which correlates with exposure. Increasing tumor control occurs with exposures of 3000 R and higher producing a TCD50120 days of 5800 +- 1100 R. The cause of death in animals containing persisting tumors could be attributed to extensive pulmonary metastases and/or intercurrent infection relative to ulceration and necrosis of the tumor. The major advantages of the use of the Syrian hamster and the cervical carcinoma as a model system and as an interface for the comparison of data from other established tumor models with that from transplantable xenogenic tumor systems is also presented

  18. Clinical Significance of CENP-H Expression in Uterine Cervical Cancer

    International Nuclear Information System (INIS)

    This work aims to investigate the expression pattern and clinicopathologic significance of centromere protein H (CENP-H) in uterine cervical cancer (UCC). The level of CENP-H expression in the paraffin sections of 62 UCC cases was determined by the SP immunohistochemical method, with complete clinicopathologic data in all cases. Statistical analysis was conducted to evaluate the prognostic and diagnostic significance of CENP-H using SPSS13.0 software package. Immunohistochemical assay showed strong CENP-H expression in 61.29% (38/62) of the paraffin-embedded cervical cancer tissues. Statistical analysis revealed a strong correlation between the CENP-H expression and the clinical classification (P=0.038) of the cervical carcinoma. The expression increased with rise of the stages. The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002) and tumor stage (P=0.001) were independent prognostic markers for the survival of UCC patients. The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001). CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC. It might be used as the important diagnostic and prognostic marker for cervical carcinoma patients, especially for those at early stage

  19. Clinical Significance of CENP-H Expression in Uterine Cervical Cancer

    Directory of Open Access Journals (Sweden)

    Mei-ying Weng

    2012-09-01

    Full Text Available Objective This work aims to investigate the expression pattern and clinicopathologic significance of centromere protein H (CENP-H in uterine cervical cancer (UCC.Methods The level of CENP-H expression in the paraffin sections of 62 UCC cases was determined by the SP immunohistochemical method, with complete clinicopathologic data in all cases. Statistical analysis was conducted to evaluate the prognostic and diagnostic significance of CENP-H using SPSS13.0 software package.Results Immunohistochemical assay showed strong CENP-H expression in 61.29% (38/62 of the paraffin-embedded cervical cancer tissues. Statistical analysis revealed a strong correlation between the CENP-H expression and the clinical classification (P=0.038 of the cervical carcinoma. The expression increased with rise of the stages. The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002 and tumor stage (P=0.001 were independent prognostic markers for the survival of UCC patients. The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001.Conclusions CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC. It might be used as the important diagnostic and prognostic marker for cervical carcinoma patients, especially for those at early stage.

  20. Effect of 5'-DFUR used concurrently in radiotherapy and immunotherapy uterine cervical cancer. Pilot study

    International Nuclear Information System (INIS)

    We conducted a preliminary controlled study in order to evaluate 5'-DFUR dose dependency in efficacy and safety in combination therapy of radiotherapy, 5'-DFUR and SPG for patients with uterine cervical cancer, which was regarded as suitable for cases of radiotherapy. The patients were randomly allocated into group A (5'-DFUR 600 mg/body/day) and group B (5'-DFUR 800 mg/body/day), who underwent radiotherapy with simultaneous administration of 5'-DFUR and SPG (20 mg twice/week or 40 mg/week). Those enrolled were 33 patients in stage II, III or IVa with histologically diagnosed primary squamous cell carcinoma of uterine cervix. CR was shown in 19, PR in 7, NC in 1, and PD in 2 out of 29 efficacy-evaluable cases, so the overall response rate was 89.7% (26/29, 95%CI 72.7%-97.8%). Regarding safety, some side effects were observed in 26 out of 33 safety-evaluable cases (81.3%, 95%CI 63.6%-92.8%), but no serious cases. No significant difference in efficacy and safety was observed between the two treatment groups. These results suggested that the combination therapy of radiotherapy, 5'-DFUR and SPG might be one of the therapies whose effectiveness must be confirmed for advanced squamous cell carcinoma of uterine cervix. To confirm dose dependency of 5'-DFUR, it seems further consideration with more patients is needed. (author)

  1. Cytopathological and immunohistochemical study for estimating radiotherapeutic effects in uterine cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Begum, Matia (Hiroshima Univ. (Japan). School of Medicine)

    1993-06-01

    In order to estimate the effects of radiation on cancer tissue, cytopathological findings, BrdU labelling index (L.I), tumor markers and C-myc oncogene products were examined in 30 patients of uterine cervical cancer, before radiation, at around 10 Gy, 30 Gy, 50 Gy and at the end of the therapy. In order to assess the radiotherapeutic effects, the cytological, histological, immunohistological findings were evaluated by Papanicolaou's classification, Oboshi and Shimasato's grading system and BrdU L.I. In the cytology, the radiation effect, such as the enlargement and vacuolation of the nuclei and cytoplasm, was observed at around 10 Gy of radiation, and significantly increased at around 30 Gy showing lysis of the cells and pyknosis of the nuclei. The histological observation recorded remarkable change in the cancer tissue at around 30 Gy of radiation. The BrdU L.I. showed a meaningful decrease around 30 Gy in the radiosensitive cases compared with the radioresistant cases. Moreover, immunohistochemical investigation indicated the location of SCC and SLX in the cytoplasm of the cancer cells and of C-myo oncogene product at around 10 Gy. Ras oncogene was not found in the adenocarcinoma cases investigated. From these findings it is concluded that BrdU L.I., revealed by immunohistological study, is the most suitable indicator to estimate the response of radiation in cancer cells of the uterine cervix and that C-myc oncogene product has the potentiality to be used as a prognostic factor in uterine cervical cancer treated by radiation therapy. (author).

  2. Cytopathological and immunohistochemical study for estimating radiotherapeutic effects in uterine cervical cancer

    International Nuclear Information System (INIS)

    In order to estimate the effects of radiation on cancer tissue, cytopathological findings, BrdU labelling index (L.I), tumor markers and C-myc oncogene products were examined in 30 patients of uterine cervical cancer, before radiation, at around 10 Gy, 30 Gy, 50 Gy and at the end of the therapy. In order to assess the radiotherapeutic effects, the cytological, histological, immunohistological findings were evaluated by Papanicolaou's classification, Oboshi and Shimasato's grading system and BrdU L.I. In the cytology, the radiation effect, such as the enlargement and vacuolation of the nuclei and cytoplasm, was observed at around 10 Gy of radiation, and significantly increased at around 30 Gy showing lysis of the cells and pyknosis of the nuclei. The histological observation recorded remarkable change in the cancer tissue at around 30 Gy of radiation. The BrdU L.I. showed a meaningful decrease around 30 Gy in the radiosensitive cases compared with the radioresistant cases. Moreover, immunohistochemical investigation indicated the location of SCC and SLX in the cytoplasm of the cancer cells and of C-myo oncogene product at around 10 Gy. Ras oncogene was not found in the adenocarcinoma cases investigated. From these findings it is concluded that BrdU L.I., revealed by immunohistological study, is the most suitable indicator to estimate the response of radiation in cancer cells of the uterine cervix and that C-myc oncogene product has the potentiality to be used as a prognostic factor in uterine cervical cancer treated by radiation therapy. (author)

  3. Prognostic value of podoplanin expression in intratumoral stroma and neoplastic cells of uterine cervical carcinomas

    Directory of Open Access Journals (Sweden)

    Filomena M Carvalho

    2010-01-01

    Full Text Available OBJECTIVE: To investigate the clinicopathological significance of podoplanin expression in the intratumoral stroma and neoplastic cells of early stage uterine cervical cancer. MATERIALS AND METHODS: A total of 143 patients with clinical stage I and IIA uterine cervical carcinomas underwent surgery between 2000 and 2007. Clinicopathological data and slides associated with these cases were retrospectively reviewed. Immunodetection of podoplanin expression in histologic sections of tissue microarray blocks was performed using the monoclonal antibody D2-40. RESULTS: Expression of podoplanin was detected in neoplastic cells in 31/143 (21.6% cases, with 29/31 (93.5% of these cases diagnosed as squamous carcinoma. For all of the cases examined, the strongest signal for podoplanin expression was observed at the proliferating edge of the tumor nests. The rate of positive podoplanin expression for node-positive cases was lower than that of node-negative (18.9% vs. 22.6%, respectively. Furthermore, the rate of positive podoplanin expression in fatal cases was 10.5% vs. 21.6%, respectively. In 27/143 (18.8% cases, podoplanin expression was detected in fibroblasts of the intratumoral stroma, and this expression did not correlate with patient age, clinical stage, tumor size, histologic type, depth of infiltration, or vascular involvement. Moreover, expression of podoplanin in intratumoral stroma fibroblasts was only negatively associated with nodal metastasis. A greater number of fatal cases was observed among negative intratumoral stroma fibroblasts (15.5% vs. 3.7%, respectively, although this difference was not significant. CONCLUSIONS: These preliminary results suggest that podoplanin may have a role in host-tumor interactions and, as a result, may represent a favorable prognostic factor for squamous cervical carcinomas.

  4. Nontuberculous Mycobacterial Infection in the Uterine Cervix Mimics Invasive Cervical Cancer in Immunocompetent Woman.

    Science.gov (United States)

    Ukita, Masayo; Aoki, Masato; Murakami, Kosuke; Takaya, Hisamitsu; Kotani, Yasushi; Shimaoka, Masao; Tobiume, Takako; Nakai, Hidekatsu; Tsuji, Isao; Suzuki, Ayako; Mandai, Masaki

    2016-03-01

    Nontuberculous mycobacterial (NTM) infection is increasing across the world. Although the most common clinical manifestation of NTM disease is lung disease, a rare form of disseminated NTM disease has also been documented. Disseminated NTM usually develops in severely immunocompromised individuals, especially those with advanced AIDS. This manifestation is rare in non-HIV-infected hosts and is associated with immunosuppressed conditions. However, recent reports have suggested that disseminated NTM disease in immunocompetent patients without HIV infection has been increasing. Dissemination may involve any organ system, but a case in the female genital tract has never been reported. We report a case in a 67-yr-old previously healthy woman who presented with a disseminated NTM infection in the uterine cervix. The primary presentation was general fatigue and body weight loss. The patient also presented with a mass formation that mimicked cervical cancer on magnetic resonance imaging. In addition to the cervical mass, the patient presented with a mass formation in the omentum; wall thickening of the vagina, bladder, and ureter; and retention of pleural/peritoneal fluid. Vaginal cytology was negative. A diagnosis was made only after detecting acid-fast bacilli in a biopsy specimen of cervical mass, which was conducted under suspicion of cervical malignancy. Then, Mycobacterium aviumwas confirmed in a polymerase chain reaction test of cervical tissue. After administration of antimycobacterial therapy, the mass and other findings on magnetic resonance imaging disappeared. Infection in multiple organs leads to the diagnosis of disseminated NTM. This case indicates that, for prompt and accurate diagnosis, efforts to detect specific lesions by an imaging study and to confirm diagnosis pathologically are equally important, especially when local cytology is not convincing. The clinical course of this case may serve as a useful reference in the diagnosis and treatment of NTM. PMID:26535986

  5. Pelvic imaging: multicystic uterine cervical lesions. Can magnetic resonance imaging differentiate benignancy from malignancy?

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    Okamoto, Y.; Tanaka, Y.O.; Nishida, M.; Tsunoda, H.; Yoshikawa, H. [National Hospital Tokyo, Disaster Medical Center (Japan). Dept. of Radiology

    2004-02-01

    To evaluate whether magnetic resonance imaging (MRI) can be used to differentiate between malignant and benign multicystic uterine cervical lesions. Twenty-two patients with cervical adenocarcinomas, including minimal deviation adenocarcinoma, and five patients with benign multicystic lesions were classified as a percentage of solid components on MRI. Cystic components were further classified by average cyst diameter and signal intensity of the cyst fluid on T1WI. All nine of the entirely solid lesions were malignant. In contrast, two of the entirely cystic lesions were benign. Ten of the ordinary adenocarcinomas had both solid and cystic components. However, three of the 16 solid and cystic lesions were benign. Lesions composed of cysts smaller than 5mm tended to be malignant; however, some lesions composed of larger cysts were also malignant. Three of 5 lesions with low-signal and 7 of 10 with intermediate-signal fluid were malignant. The malignancy potential was higher in the lesions with a higher percentage of solid components. However, determining whether multicystic lesions were benign or malignant based on the existence of solid components, the average cyst size, and the signal intensity of cyst fluid was impossible. Although a multicystic lesion with solid components in the deep cervical stroma had been reported as a MR finding of a minimal deviation adenocarcinoma, this does not appear to be pathognomonic.

  6. Protein profiling underscores immunological functions of uterine cervical mucus plug in human pregnancy

    DEFF Research Database (Denmark)

    Lee, Deug-Chan; Hassan, Sonia S

    2011-01-01

    The cervical mucus plug (CMP) differs from the cervical secretions of non-pregnant women, and is the ultimate sealant of the uterine cavity during pregnancy. Although several studies have analyzed biochemical properties of large glycoproteins in the CMP, comprehensive information about its protein composition is yet unavailable. We hypothesized that protein profiling of the CMP could provide key clues to its physiological functions in pregnancy. For this purpose, five CMPs obtained from women in labor at term were analyzed by LC-MS/MS. Out of 291 total proteins identified, 137 were detected in two or more samples, which included S100A8, S100A9, and complement proteins (C3, C4a, C4b, C6, and C8g). Several proteins, which have not been described in the cervical mucus of non-pregnant women or in cervicovaginal fluids, such as CD81 antigen and pregnancy zone protein, were also identified. Gene ontology analysis of identified proteins showed significant enrichment of 28 biological processes such as 'activation of plasma proteins involved in acute inflammatory response' and 'positive regulation of cholesterol esterification'. We report the proteome of CMPs from pregnant women at term for the first time, and the overall findings strongly suggest an important role for the CMP in the maintenance of pregnancy and parturition.

  7. Performance of FDG-PET/CT for diagnosis of recurrent uterine cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kitajima, Kazuhiro [Dokkyo University School of Medicine, Departments of Radiology, Shimotuka-gun, Tochigi (Japan); Dokkyo Medical University Hospital, PET Center, Mibu (Japan); Kobe University Graduate School of Medicine, Department of Radiology, Kobe (Japan); Murakami, Koji; Yamasaki, Erena; Domeki, Yasushi [Dokkyo Medical University Hospital, PET Center, Mibu (Japan); Kaji, Yasushi [Dokkyo University School of Medicine, Departments of Radiology, Shimotuka-gun, Tochigi (Japan); Sugimura, Kazuro [Kobe University Graduate School of Medicine, Department of Radiology, Kobe (Japan)

    2008-10-15

    The purpose is to evaluate the accuracy of integrated FDG-PET/CT, compared with PET alone, for diagnosis of suspected recurrence of uterine cervical cancer. Fifty-two women who had undergone treatment for histopathologically proven cervical cancer received PET/CT with suspected recurrence. PET-alone and integrated PET/CT images were evaluated by two different experienced radiologists by consensus for each investigation. A final diagnosis was confirmed by histopathology, radiological imaging, and clinical follow-up for over 1 year. Patient-based analysis showed that the sensitivity, specificity, and accuracy of PET/CT were 92.0% (23/25), 92.6% (25/27), and 92.3% (48/52), respectively, while for PET, the corresponding figures were 80.0% (20/25), 77.8% (21/27), and 78.8% (41/52), respectively. PET/CT resolved the false-positive PET results due to hypermetabolic activity of benign/inflammatory lesions and physiological variants, and was able to detect lung metastasis, local recurrence, peritoneal dissemination, para-aortic lymph node metastasis, and pelvic lymph node metastasis missed by PET alone. However, tiny local recurrence and lymph node metastasis could not be detected even by PET/CT. FDG-PET/CT is a useful complementary modality for providing good anatomic and functional localization of sites of recurrence during follow-up of patients with cervical cancer. (orig.)

  8. Clinical outcomes of adjuvant radiation therapy and prognostic factors in early stage uterine cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Ju; Rhee, Woo Joong; Choi, Seo Hee; Kim, Gwi Eon; Kim, Yong Bae [Dept. of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul (Korea, Republic of); Nam, EunJi; Kim, Sang Wun; Kim, Sung Hoon [Dept. of Radiation Oncology, Obstetrics and Gynecology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2015-06-15

    To evaluate the outcomes of adjuvant radiotherapy (RT) and to analyze prognostic factors of survival in the International Federation of Gynecology and Obstetrics (FIGO) IB-IIA uterine cervical cancer. We retrospectively reviewed the medical records of 148 patients with FIGO IB-IIA uterine cervical cancer who underwent surgery followed by adjuvant RT at the Yonsei Cancer Center between June 1997 and December 2011. Adjuvant radiotherapy was delivered to the whole pelvis or an extended field with or without brachytherapy. Among all patients, 57 (38.5%) received adjuvant chemotherapy either concurrently or sequentially. To analyze prognostic factors, we assessed clinicopathologic variables and metabolic parameters measured on preoperative {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). To evaluate the predictive performance of metabolic parameters, receiver operating characteristic curve analysis was used. Overall survival (OS) and disease-free survival (DFS) were analyzed by the Kaplan-Meier method. The median follow-up period was 63.2 months (range, 2.7 to 206.8 months). Locoregional recurrence alone occurred in 6 patients, while distant metastasis was present in 16 patients, including 2 patients with simultaneous regional failure. The 5-year and 10-year OSs were 87.0% and 85.4%, respectively. The 5-year and 10-year DFSs were 83.8% and 82.5%, respectively. In multivariate analysis, pathologic type and tumor size were shown to be significant prognostic factors associated with both DFS and OS. In subset analysis of 40 patients who underwent preoperative PET/CT, total lesion glycolysis was shown to be the most significant prognostic factor among the clinicopathologic variables and metabolic parameters for DFS. Our results demonstrated that adjuvant RT following hysterectomy effectively improves local control. From the subset analysis of preoperative PET/CT, we can consider that metabolic parameters may hold prognostic significance in early uterine cervical cancer patients. More effective systemic treatments might be needed to reduce distant metastasis in these patients.

  9. Clinical significations of G2-M stage partial synchronization on radiation therapies of uterine cervical carcinomas

    International Nuclear Information System (INIS)

    The present study revealed that irradiation-induced changes of repopulation and redistribution played an important role in radiosensitivity and cure process of human uterine cervical carcinoma. DNA measurements by a microspectrophotometer were made on Feulgen stained biopsy specimens obtained from 20 patients. On the other hand, flow-microfluorometric measurements with Fried's computed cell cycle analysis were made on transplanted human cervical carcinomas. The mean nuclear DNA amount of human cervical carcinoma cells increased according as the irradiation doses increase until 2,000 rad. Moreover, as regards with the mean nuclear diameter of cancer cells the same phenomenon was recognized, and there was an interrelation between the increase of mean nuclear DNA amount and that of mean nuclear diameter. This phenomenon was proved in nuclear DNA analysis by flow-microfluorometric measurements on transplanted human cervical carcinoma in nude mice. Computed cell cycle analysis of F.M.F. data demonstrated that this phenomenon was due to irradiation-induced changes of repopulation and redistribution. That is to say, irradiation induces the increase of cycling cells and then partial synchronization to G2-M stage. Examination of the interrelation between this phenomenon at 500 rad and 5 years survival rate demonstrated that there was more increase of nuclear DNA amount in the good prognosis group than in the poor prognosis group. Estimation of residual cells near the G1 stage at 2,000 rad demonstrated that there were more residual cells near the G1 stage in the poor prognosis group than in the good prognosis group. (author)

  10. Dynamic contrast-enhanced MRI in the diagnosis of uterine cervical cancer

    International Nuclear Information System (INIS)

    Objective: To investigate the imaging characteristics of dynamic contrast-enhanced MR imaging (DCE-MRI) in uterine cervical cancer(UCC), and to evaluate the efficacy of DCE-MRI in the diagnosis of UCC. Methods: A total of 39 cases of scratch-pathologically confirmed UCC patients with MRI data were analyzed (one case of carcinoma in sim being negative on MRI was excluded in this study). Time- intensity curves of ROI in pathological regions and adjacent normal regions were obtained and the enhanced rates at different times (16,32,48,64 and 300 s) were calculated. The ARSI% and MRSI% of various groups were compared with t test. Results: All the 39 lesions enhanced at 16 s in DCE, and there was maximum signal contrast between lesions and the surrounding normal tissue in the early arterial phase. ARSI% of tumor (1.97 ± 0.55)% was higher than normal tissue (1.22 ± 0.56 )%, and there was statistically significant difference between them (t=151.000, P3 cm group[(1.70 ± 0.25)% and (2.26 ± 0.18)%] were higher than ?3 cm group [(0.57 ± 0.16)% and (0.73 ± 0.04)%]. ARSI% and MRSI% were higher in the peri-uterine tissue infiltration group [(1.69 ± 0.21)% and (2.26 ± 0.11)%] than that of confined group [(0.63 ± 0.23)% and (0.83 ± 0.03)%] with statistically significant difference (P<0.05). The TIC of the 39 cases with UCC included type I in 25 cases(25/39), type II in 14 cases (14/39), and there was no type III cases. The TICs of the surrounding normal tissue were of type III (26/39) and type II (11/39), and only 2 cases type I. Conclusions: The DCE-MRI can reflect the blood supply of the UCCs quantitatively. The early arterial phase in DCE-MRI can improve the detection rate of small lesions. The ARSI% and MRSI% may be helpful in some degree in prognostic assessment and staging of the uterine cervical cancer. (authors)

  11. Factores de riesgo para cáncer de cuello uterino Risk factors for uterine cervical cancer

    Directory of Open Access Journals (Sweden)

    Ricardo Ortiz Serrano

    2004-06-01

    Full Text Available El cáncer del cuello uterino es una de las neoplasias malignas de mayor incidencia y mortalidad entre las mujeres de todas partes del mundo, hallazgo que resulta paradójico si se tiene en cuenta que el cuello uterino es de fácil acceso y existen estrategias debidamente probadas que permiten un diagnóstico y tratamiento precoz. En esta revisión se describe detalladamente la epidemiología del cáncer del cuello uterino, en especial los factores de riesgo relacionados con la génesis de la neoplasia y su diagnóstico tardío.Cervical cancer is one of the most frequent neoplasms and one of the most common causes of death among women of reproductive age in the world. These figures are paradoxical if we consider that uterine cervix is easily accessible and that there are proven strategies to early diagnosis and effective treatments. In this paper we provide a detailed review of the epidemiology of cervical cancer, with emphasis on related risk factors associated with carcinogenesis and delayed diagnosis.

  12. Clinical significance of magnetic resonance imaging (MRI) in evaluation of radiotherapeutic effect on uterine cervical cancer

    International Nuclear Information System (INIS)

    Serial magnetic resonance imaging (MRI) studies were performed in 27 patients undergoing primary radiation therapy for invasive cervical carcinoma, to assess the efficacy of this therapy. MRI findings included a high intensity area (HIA) in the uterine cervix and five parameters indicative of extrauterine spreading of the carcinoma: vaginal invasion, parametrial invasion, vesical invasion, rectal invasion and lymph node enlargement. In 26 of the 27 (96%) cases, the HIA was found prior to treatment, and remained in 17 (63%) cases at the end of the treatment. But in 10 of the patients with a residual HIA, this region resolved 3 to 8 months after treatment, and these patients had no evidence of residual tumor in the cervix on pathologic examination. The accuracy was lower in MRI examinations performed less than 6 months after the treatment (49%) than in examinations performed more than 7 months after the treatment (93%), suggesting that the HIA in the early post-treatment phase may be related to inflammatory changes. Findings indicative of extrauterine spreading decreased following treatment, but patients with recurrence had higher scores than those with no evidence of recurrence completion of the primary therapy. Furthermore, in 2 patients with local recurrence more than 1 year after treatment, the abnormal MRI findings reappeared and increased after the initial resolution of these findings with treatment. The present results indicate that MRI is clinically effective in evaluating the effects of radiotherapy in patients with cervical cancer. (author)

  13. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer.

    Science.gov (United States)

    Kawano, Mahiru; Mabuchi, Seiji; Matsumoto, Yuri; Sasano, Tomoyuki; Takahashi, Ryoko; Kuroda, Hiromasa; Kozasa, Katsumi; Hashimoto, Kae; Isobe, Aki; Sawada, Kenjiro; Hamasaki, Toshimitsu; Morii, Eiichi; Kimura, Tadashi

    2015-01-01

    Granulocyte-colony stimulating factor (G-CSF) producing malignant tumor has been reported to occur in various organs, and has been associated with poor clinical outcome. The aim of this study is to investigate the significance of tumor G-CSF expression in the chemosensitivity of uterine cervical cancer. The clinical data of recurrent or advanced cervical cancer patients who were treated with platinum-based chemotherapy were analyzed. Clinical samples, cervical cancer cell lines, and a mouse model of cervical cancer were employed to examine the mechanisms responsible for the development of chemoresistance in G-CSF-producing cervical cancer, focusing on myeloid-derived suppressor cells (MDSC). As a result, the tumor G-CSF expression was significantly associated with increased MDSC frequencies and compromised survival. In vitro and in vivo experiments demonstrated that the increased MDSC induced by tumor-derived G-CSF is involved in the development of chemoresistance. The depletion of MDSC via splenectomy or the administration of anti-Gr-1 antibody sensitized G-CSF-producing cervical cancer to cisplatin. In conclusion, tumor G-CSF expression is an indicator of an extremely poor prognosis in cervical cancer patients that are treated with chemotherapy. Combining MDSC-targeting treatments with current standard chemotherapies might have therapeutic efficacy as a treatment for G-CSF-producing cervical cancer. PMID:26666576

  14. Clinicopathological analysis of 91 cases of uterine cervical cancer (including 38 cases of CIN III)

    International Nuclear Information System (INIS)

    A total of 91 cases of uterine cervical cancer, consisting of 38 cases of carcinoma in situ (CIN III) and 53 cases of stage I-IV cervical cancer, were retrospectively and clinicopathologically analyzed. The standard treatment given to these patients consisted of hysterectomy or conization for CIN III; observation of cases of mild to moderate dysplasia; radical hysterectomy plus pelvic lymph node dissection for stage I and II cervical cancer; and radiotherapy for stage III and IV cervical cancer. Postoperative irradiation consisted of irradiation of the whole pelvis with 40-50 Gy. The patients who were not treated surgically underwent 40 Gy external irradiation of the whole pelvis, followed by an additional 20 Gy with shielding and internal irradiation with an RALS. When lymph node metastasis was present, the nodes were irradiated with 40-50 Gy. The mean age of the 38 patients with CIN III was 45.2 years old, and they were para 0-4. In 24 (63.2%) of them the cancer was detected by cytodiagnosis as part of screening. Radical hysterectomy, simple hysterectomy, and conization were performed in 25 patients, 7 patients, and 6 patients, respectively. No recurrences have been detected, and the survival rate is 100%. The mean age of the 53 patients with cervical cancer stage I-IV was 62.4 years old, and they were para 0-10. There were 25 patients with stage I disease, 15 patients with stage II disease, 6 patients with stage III, and 7 patients with stage IV, and their 5-year survival rate was 82.4%, 68.8%, 66.7%, and 42.9%, respectively. Radioenteritis and radiocystitis occurred as adverse radiation effects. Pathologic factors influencing lymph node metastasis were examined by a multivariate analysis based on the data from 25 patients with stage I and II who underwent hysterectomy. The results of the analysis indicated the importance of screening and the choice of appropriate surgical method/technique, as well as the need for further investigation to determine the effective range of dissection to prevent lymph node metastasis. (K.H.)

  15. Distribution of Uterin Cervical Lesions and Relation Between Age and Parity Rates in the Mardin Province

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    Gülay AYDO?DU

    2013-01-01

    Full Text Available Objective: The aim of this study is to evaluate the incidence and distribution of cervical lesions and compare characteristics such as parity and age of the women in Mardin province.Material and Method: Pap smears were drawn from the women screened at Mardin Gynecology and Pediatric Diseases Hospital from 2008 to 2011. All cervicovaginal smears were conventional Pap smear samples evaluated according to the 2001 Bethesda system.Results: There were 3.332 patients in total, whose smears showed no lesions in 3.125 patients. The mean age and number of parities of those patients were 37.34±11.25 and 4.78±3.28. There were 207 smears showing any lesions in cervix; ASC-US, ASC-H, LSIL, HSIL, AGC, squamous cell carcinoma and endocervical adenocarcinoma in 151 (72.94%; 16 (7.72%; 20 (9.66%; 8 (3.86%; 10 (4.83%; 1 (0.48% and 1 (0.48% patient, respectively. The mean age and the parities of the patients were 37.63±10.77 years and 4,74±2,92. Although there was no difference between the control and lesion groups, the parity and the age of patients who had ?4 births in both the control and lesion groups were significantly higher than the patients with parities <4 births (p=0.000. There was no difference within the cervical lesion group comparing the ASC-US group with the total of the other lesions.Conclusion: High parity was one of the risk factor for having a lesion in uterine cervix in this population. This study represents an initial attempt to reflect the prevalence and the distribution of cervical lesions and their relation with the parity rates in the eastern regions in Turkey.

  16. In vitro analysis of muscular contractile ability and passive biomechanical properties of uterine cervical samples from nonpregnant women

    DEFF Research Database (Denmark)

    Petersen, Lone K; Oxlund, H; Uldbjerg, N; Forman, A

    1991-01-01

    We assessed the maximal muscular contractile ability, the passive biomechanical properties, and the hydroxyproline concentration in uterine cervical tissue samples from 28 nonpregnant women. Circular cervical tissue strips were mounted in organ baths and isometric tension was recorded. The mean (+/- SEM) maximal mechanical responses induced at the length of optimal mechanical performance by K+ (124 mmol/L) equaled 0.16 +/- 0.05 mN/mm2 in the distal cervix and 0.84 +/- 0.47 mN/mm2 in the proximal...

  17. Preterm birth due to cervical insufficiency complicated by placenta accreta and postpartum haemorrhage managed by uterine artery embolisation

    OpenAIRE

    Elina Tetere; Anna Jekabsone; Ieva Kalere; Dace Matule

    2014-01-01

    In this report, we present the case of a young woman undergoing her second pregnancy, with early detected shortened cervix resulting in cervical cerclage procedure. At gestational week 24/25, she presented at a hospital with signs of intra-amniotic infection and spontaneous rupture of membranes. This resulted in pathological preterm delivery with massive postpartum bleeding, which was managed by bilateral uterine artery embolization. Reasons for preterm birth and management options are discus...

  18. Changes in Bone Mineral Density in Uterine Cervical Cancer Patients After Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Okonogi, Noriyuki; Saitoh, Jun-ichi; Suzuki, Yoshiyuki, E-mail: syoshi@gunma-u.ac.jp; Noda, Shin-ei; Ohno, Tatsuya; Oike, Takahiro; Ohkubo, Yu; Ando, Ken; Sato, Hiro; Nakano, Takashi

    2013-12-01

    Purpose: To prospectively investigate the changes in bone mineral density (BMD) after pelvic radiation therapy in patients with uterine cervical cancer. Methods and Materials: Of 52 cervical cancer patients who received pelvic RT in our university hospital between 2009 and 2011, 46 patients without recurrence and who were followed up for more than 12 months were included in the study. The BMD of the irradiated region and nonirradiated regions, serum estradiol, tartrate-resistant acid phosphatase-5b, and N-terminal cross-linking telopeptide of collagen 1 were measured before, at 3 months after, and at 12 months after RT. The patient cohort was divided into 2 groups according to estradiol level before RT, and the groups were defined as postmenopausal (<40 pg/mL) and premenopausal (?40 pg/mL). Results: The mean BMDs within the irradiation field (lumbar vertebra 5) in the postmenopausal and the premenopausal groups were 0.825 and 0.910 g/cm{sup 2} before RT and 0.746 and 0.841 g/cm{sup 2} 12 months after RT, respectively. Significant decreases were observed in both groups (P<.05 and P<.01, respectively). In addition, in the premenopausal group the mean BMDs of the nonirradiated regions at thoracic vertebrae 9-12 and lumbar vertebrae 2-4 were 0.753 and 0.958 g/cm{sup 2} before RT and were significantly decreased to 0.706 and 0.921 g/cm{sup 2} 12 months after RT (P<.01 and P<.05, respectively). Estradiol significantly decreased 3 months after RT, whereas tartrate-resistant acid phosphatase-5b and N-terminal cross-linking telopeptide of collagen 1 continued to increase over time in the premenopausal group. Conclusions: A decrease in BMD in the irradiated region after RT was observed within 1 year, regardless of menopausal status. Furthermore, in premenopausal patients, pelvic RT caused a decrease in systemic BMD.

  19. Quality of life in conventional and conformal pelvic radiotherapy for cervical and uterine cancer

    International Nuclear Information System (INIS)

    Aim of the study. The development of modern radiotherapy techniques requires focusing attention on potential side effects and on the quality of life. The aim of the study was to assess radiation toxicity and quality of life in patients with cervical and endometrial cancer treated with conventional and conformal pelvic radiotherapy and to assess the impact of radiation toxicity on the latter. Material and methods. 50 patients treated with conventional and 50 patients treated with conformal pelvic radiotherapy in Clinical Department of Gynecological Radiotherapy in Lower Silesian Oncology Center between November 2004 and October 2005 entered a prospective study. We estimated the side- effects of radiotherapy according to EORTCI RTOG scales and quality of life according to the EORTC QLQ-C30 questionnaire. Results. There were no differences in physical, cognitive, emotional and role functions between the two study groups. Social functions were assessed as worse in the conformal radiotherapy group. Pain was more frequent in the conformal arm and nausea in the conventional arm. Global health and quality of life were better in the conformal arm. The performance status according to WHO affected global health and quality of life and physical functions. Late side-effects from the gastrointestinal system impaired physical, cognitive, emotional and social functions and global health and quality of life. Genitourinary late side- effects impaired physical functions and global quality of life. Conclusions. We observed no important differences in the quality of life in patients with cervical and uterine cancer receiving conventional and conformal external beam pelvic radiotherapy. Performance status according to WHO and gastrointestinal and genitourinary late side-effects affect quality of life. (authors)

  20. An assessment of interfractional uterine and cervical motion: Implications for radiotherapy target volume definition in gynaecological cancer

    International Nuclear Information System (INIS)

    Purpose: To assess interfractional movement of the uterus and cervix in patients with gynaecological cancer to aid selection of the internal margin for radiotherapy target volumes. Methods and materials: Thirty-three patients with gynaecological cancer had an MRI scan performed on two consecutive days. The two sets of T2-weighted axial images were co-registered, and the uterus and cervix outlined on each scan. Points were identified on the anterior uterine body (Point U), posterior cervix (Point C) and upper vagina (Point V). The displacement of each point in the antero-posterior (AP), supero-inferior (SI) and lateral directions between the two scans was measured. The changes in point position and uterine body angle were correlated with bladder volume and rectal diameter. Results: The mean difference (±1SD) in Point U position was 7 mm (±9.0) in the AP direction, 7.1 mm (±6.8) SI and 0.8 mm (±1.3) laterally. Mean Point C displacement was 4.1 mm (±4.4) SI, 2.7 mm (±2.8) AP, 0.3 (±0.8) laterally, and Point V was 2.6 mm (±3.0) AP and 0.3 mm (±1.0) laterally. There was correlation for uterine SI movement in relation to bladder filling, and for cervical and vaginal AP movement in relation to rectal filling. Conclusion: Large movements of the uterus can occur, particularly in the superior-inferior and anterior-posterior directions, but cervical displacement is less marked. Rectal filling may affect cervical position, while bladder filling has more impact on uterine body position, highlighting the need for specific instructions on bladder and rectal filling for treatment. We propose an asymmetrical margin with CTV-PTV expansion of the uterus, cervix and upper vagina of 15 mm AP, 15 mm SI and 7 mm laterally and expansion of the nodal regions and parametria by 7 mm in all directions

  1. Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy

    International Nuclear Information System (INIS)

    Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of 69 Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

  2. Lexington studies of Cf-252 brachytherapy for advanced cervical and uterine cancer

    International Nuclear Information System (INIS)

    The most important tumors selected for study in the Lexington clinical trial of /sup 252/Cf have been the advanced stages of cervical cancer, i.e. stage III and IV. These tumors are poorly controlled by conventional photon radiotherapy and local persistence or pelvic recurrence of tumor occurs commonly after radiotherapy in 60-90% of treated patients. During 1975-1979, a group of patients were treated using conventional radiotherapy with delayed /sup 137/Cs implants, experimental radiation using a delayed /sup 252/Cf implant instead of /sup 137/Cs, and early /sup 252/Cf implants before pelvic irradiation. These schedules and the clinical responses of tumors were studied in sequential studies in the authors' clinic. The characteristics of tumor responses are reviewed as well as patient survival. The early implant schedule was developed to treat tumors when they were of maximal size and presumably radioresistance, presumed due to hypoxia. 5-year survival rates were determined for the different treatments and was 54% for the Cf implants performed early and approximately 15% when delayed /sup 137/Cs or /sup 252/Cf implants were used. These studies indicate that implant schedule was important to outcome for /sup 252/Cf neutron brachytherapy and that the early implant of cervix cancer conferred an advantage for tumor control. Primary and recurrent uterine carcinomas were also studied and were found to be neutron sensitive

  3. A thermosensitive gel formulation of an empirical traditional Chinese prescription for treating cervical erosion

    Directory of Open Access Journals (Sweden)

    Shuqing Zhou

    2012-10-01

    Full Text Available Cervical erosion, a pathological change associated with chronic cervicitis, is a common condition that is difficult to cure. Many patients particularly those with mild or medium infection and those preparing for pregnancy require a simple but effective medication. In this study, extracts of an empirical herbal prescription composed of six Chinese traditional drugs viz Cortex Phellodendri, Rhizoma Coptidis, Olibanum, Myrrha, borneol and catechu were formulated to facilitate intravaginal administration and improve efficacy. An extract of the first four components was formulated with borneol as a thermosensitive gel (TG while an extract of catechu used to prepare a regular gel (CG because of a chemical incompatibility. The optimized TG was prepared using poloxamer 407 and poloxamer 188. The CG was prepared using glycerin, carbopol and triethanolamine. The gels were characterized in vitro in terms of release of berberine (TG and total catechins (CG and in vivo in a rat model of cervical erosion. Treatment by once daily application of the TG for 7 days followed by once daily application of the CG for 3 days produced a restoration of normal tissues. Gel formulation of the empirical Chinese traditional remedy appears to provide a promising treatment for cervical erosion.

  4. The Prevalence and pattern of HPV-16 immunostaining in uterine cervical carcinomas in Ethiopian women: a pilot study

    Directory of Open Access Journals (Sweden)

    Mona M Rashed

    2011-03-01

    Full Text Available INTRODUCTION: Cancer of the cervix uteri is the second most common cancer among women worldwide. The association of human papillomavirus (HPV infection with cervical carcinogenesis is well documented. This is a pilot study aiming to studying the prevalence and the pattern of Human Papilloma Virus Type 16 (HPV16 by immunostaining in the tissues of cervical carcinomas of Ethiopian women. METHODS: 20 specimens of uterine cervical carcinomas were studied histopathologically and immunohistochemically for HPV16. RESULTS: Histologically the specimens were classified as: Ten cases were Non Keratinized Squamous cell carcinoma (NKSCC, six cases were Keratinized Squamous Cell Carcinoma (KSCC and four cases were Adenocarcinoma (ADC. Immunohistochemistry study showed positivity in eleven cases (55%; seven cases (35% were non-keratinized squamous cell carcinoma; three cases (15% were keratinized squamous cell carcinoma and one case (5% belonged to the adenocarcinomas. CONCLUSION: This study reveals a significant detection of HPV in Ethiopian women by the use of advanced techniques such as Immunohistochemistry (IHC. The data of this study suggested that the marked expression of the HPV 16 was in the less differentiated uterine cervix carcinomas

  5. Predictive role of post-treatment [18F]FDG PET/CT in patients with uterine cervical cancer

    International Nuclear Information System (INIS)

    Objective: To evaluate the efficacy of post-treatment positron emission tomography (PET)/computed tomography (CT) for identification of tumor recurrence, and to determine whether [18F]fluorodeoxyglucose (FDG) uptake measured as the maximum standardized uptake value (SUVmax) has predictive role regarding survival in patients with uterine cervical cancer. Methods: Medical records from 276 women with uterine cervical cancer who had post-treatment [18F]FDG PET/CT performed were retrospectively reviewed. Results of PET/CT scans were compared with histological or clinical examination. Results: Ninety-five (34.4%) of the 276 patients had documented recurrence by either surgical biopsy or clinical and imaging follow-up. Median duration from treatment to PET/CT scan was 24 months (range, 6–307). The overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of post-treatment PET/CT were 94.7%, 87.8%, 80.4%, 97%, and 90.2%, respectively. The PET/CT scan modified both the diagnostic or treatment plan in 67 patients (24.3%). Patients were divided into two groups according to cut-off SUVmax established on the basis of ROC analysis (<5.25 vs. ≥5.25), and there was a significant difference in OS between groups (p = 0.001). In addition, the 5-year progression-free survival (PFS) and OS rates of patients with a negative PET/CT scan for recurrence were significantly better than those with a positive PET/CT (98.62% vs. 17.83%, p < 0.0001 for PFS, 99.31% vs. 85.38%, p = 0.0015 for OS). Conclusion: Post-treatment PET/CT scan is a sensitive and accurate surveillance modality, and provides prognostic information in uterine cervical cancer. Furthermore, it may allow individualization of patient care.

  6. Survival prediction using artificial neural networks in patients with uterine cervical cancer treated by radiation therapy alone

    International Nuclear Information System (INIS)

    We evaluated the usefulness of artificial neural networks (ANNs) for survival prediction in patients with uterine cervical cancer treated by radiotherapy. We used data from 134 patients with uterine cervical cancer treated by combined external and high-dose-rate remote afterloading intracavitary radiotherapy between 1978 and 1993. The ANNs were trained using the data from 67 randomly selected patients. Using the trained ANNs, we predicted the 5-year survival in the remaining 67 patients, and compared it with the known 5-year survival. The performance of the ANNs was evaluated using a receiver operating characteristic (ROC) curve and was compared using the area under the ROC curve (Az). When fundamental factors, such as age, performance status, hemoglobin, total protein, International Federation of Gynecology and Obstetrics (FIGO) stage, and histological type were used as inputs in the ANNs, Az was 0.5483±0.0145 (mean±SD). When the histological grading of radiation effect determined by periodic biopsy examination was used in addition to the fundamental factors, Az was highest (0.7782±0.0105). When the cytological grading of radiation effect by the periodic smear was used in addition to the fundamental factors, Az was 0.5523±0.0135, which was not significantly different from that when only the fundamental factors were used. ANNs allow us to evaluate the importance of prognostic factors, and make it possible to predict the survival of each patient. Using ANNs, the combination of histological grading of radiation effect determined by periodic biopsy examination, in addition to the fundamental factors, is the most effective for prediction of survival in patients with uterine cervical cancer. (author)

  7. Combined therapy of intra-arterial reservoir and radiotherapy on advanced uterine cervical cancer

    International Nuclear Information System (INIS)

    The efficacy of combined therapy of intra-arterial reservoir and radiotherapy was studied on 12 patients with advanced cervical uterine cancer. The patients were classified into two groups according to the agents used: Group A, intra-arterial administration of CDDP (10 mg/body/day) and 5-FU (250 mg/body/day) for 10 days; Group B, oral administration of Vp-16 (25 mg/body/day) for 7 days, followed by intra-arterial infusion of CDDP (100 mg/m2) for the first day and ADM (50 mg/m2) for the third day and intravenous infusion of CPM (200 mg/body/day) for 3 days. The size of tumor was reduced by several courses of chemotherapy preoperatively, then radiotherapy was performed. Whole-pelvis irradiation (40 Gy) was performed on 11 patients postoperatively, and internal irradiation (20 Gy) was performed preoperatively on 3 to control genital hemorrhage and postoperatively in 6. The reduced tumor size was evaluated by CT and MR. The efficacy rate was 75% (CR, 1; PR, 5; NC, 2)in the Group A and 50% (PR, 2; NC, 2) in the Group B, showing that intra-arterial infusion alone is enough to reduce the tumor size. Occlusion of the anterior raminus of left internal iliac artery was observed in one in the Group A. Transient leukopenia was observed in 2 in the Group A, which did not required any special treatment, and all patients in the Group B showed bone marrow suppression. The selection of irradiation field is still controversial, which needs to be further studied. (S.Y.)

  8. Preterm birth due to cervical insufficiency complicated by placenta accreta and postpartum haemorrhage managed by uterine artery embolisation

    Directory of Open Access Journals (Sweden)

    Elina Tetere

    2014-06-01

    Full Text Available In this report, we present the case of a young woman undergoing her second pregnancy, with early detected shortened cervix resulting in cervical cerclage procedure. At gestational week 24/25, she presented at a hospital with signs of intra-amniotic infection and spontaneous rupture of membranes. This resulted in pathological preterm delivery with massive postpartum bleeding, which was managed by bilateral uterine artery embolization. Reasons for preterm birth and management options are discussed. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 746-748

  9. Pre-invasive cervical disease and uterine cervical cancer in Brazilian adolescents: prevalence and related factors Doença cervical pré-invasiva e câncer cérvico-uterino em adolescentes brasileiras: prevalência e fatores associados

    OpenAIRE

    Denise Leite Maia Monteiro; Alexandre José Baptista Trajano; Kátia Silveira da Silva; Fábio Bastos Russomano

    2006-01-01

    The objective was to describe the prevalence and factors associated with uterine cervical cancer (CA) and high-grade squamous intraepithelial lesions (HSIL) in adolescents. A cross-sectional study was carried out with 702 sexually active adolescents treated at a general hospital in Rio de Janeiro, Brazil, from 1993 to 2002. Screening was performed by cytopathology and colposcopy and confirmation by biopsy. Exposure variables were socio-demographic characteristics and those related to reproduc...

  10. Role Of Family Planning Practices In The Control And Prevention of Uterine Cervical Cancer- A Multivariate Analysis

    Directory of Open Access Journals (Sweden)

    Sharma S

    1995-01-01

    Full Text Available Research Question: Does acceptance of family planning reduce the risk of uterine cervical cancer? Objective: To study the association between usage of contraceptive methods and cervical carcinogenesis. Study design: Case control study. Settings: Urban Area â€" Hospital Based. Participants: 160 women having different degrees of dysplasia and 173 women having normal pap smears. Statistical Analysis: Multivariate Analysis. Results: None of the three widely prevalent Family Planning practices viz. IUD condoms and tubectomy turned out to be significant in the development of dysplasia, however, age at consummation of marriage before 18 years and illiteracy were significant. Use of IUD offered protection against carcinoma in situ (CIS and disease of invasive nature. Non- users of condoms were also at risk marginally failing to attain statistical significance.

  11. Prognostic analysis of uterine cervical cancer treated with postoperative radiotherapy: importance of positive or close parametrial resection margin

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yi Jun; Lee, Kyung Ja; Park, Kyung Ran [Dept. of Radiation Oncology, (Korea, Republic of); and others

    2015-06-15

    To analyze prognostic factors for locoregional recurrence (LRR), distant metastasis (DM), and overall survival (OS) in cervical cancer patients who underwent radical hysterectomy followed by postoperative radiotherapy (PORT) in a single institute. Clinicopathologic data of 135 patients with clinical stage IA2 to IIA2 cervical cancer treated with PORT from 2001 to 2012 were reviewed, retrospectively. Postoperative parametrial resection margin (PRM) and vaginal resection margin (VRM) were investigated separately. The median treatment dosage of external beam radiotherapy (EBRT) to the whole pelvis was 50.4 Gy in 1.8 Gy/fraction. High-dose-rate vaginal brachytherapy after EBRT was given to patients with positive or close VRMs. Concurrent platinum-based chemoradiotherapy (CCRT) was administered to 73 patients with positive resection margin, lymph node (LN) metastasis, or direct extension of parametrium. Kaplan-Meier method and log-rank test were used for analyzing LRR, DM, and OS; Cox regression was applied to analyze prognostic factors. The 5-year disease-free survival was 79% and 5-year OS was 91%. In univariate analysis, positive or close PRM, LN metastasis, direct extension of parametrium, lymphovascular invasion, histology of adenocarcinoma, and chemotherapy were related with more DM and poor OS. In multivariate analysis, PRM and LN metastasis remained independent prognostic factors for OS. PORT after radical hysterectomy in uterine cervical cancer showed excellent OS in this study. Positive or close PRM after radical hysterectomy in uterine cervical cancer correlates with poor prognosis even with CCRT. Therefore, additional treatments to improve local control such as radiation boosting need to be considered.

  12. Prognostic analysis of uterine cervical cancer treated with postoperative radiotherapy: importance of positive or close parametrial resection margin

    International Nuclear Information System (INIS)

    To analyze prognostic factors for locoregional recurrence (LRR), distant metastasis (DM), and overall survival (OS) in cervical cancer patients who underwent radical hysterectomy followed by postoperative radiotherapy (PORT) in a single institute. Clinicopathologic data of 135 patients with clinical stage IA2 to IIA2 cervical cancer treated with PORT from 2001 to 2012 were reviewed, retrospectively. Postoperative parametrial resection margin (PRM) and vaginal resection margin (VRM) were investigated separately. The median treatment dosage of external beam radiotherapy (EBRT) to the whole pelvis was 50.4 Gy in 1.8 Gy/fraction. High-dose-rate vaginal brachytherapy after EBRT was given to patients with positive or close VRMs. Concurrent platinum-based chemoradiotherapy (CCRT) was administered to 73 patients with positive resection margin, lymph node (LN) metastasis, or direct extension of parametrium. Kaplan-Meier method and log-rank test were used for analyzing LRR, DM, and OS; Cox regression was applied to analyze prognostic factors. The 5-year disease-free survival was 79% and 5-year OS was 91%. In univariate analysis, positive or close PRM, LN metastasis, direct extension of parametrium, lymphovascular invasion, histology of adenocarcinoma, and chemotherapy were related with more DM and poor OS. In multivariate analysis, PRM and LN metastasis remained independent prognostic factors for OS. PORT after radical hysterectomy in uterine cervical cancer showed excellent OS in this study. Positive or close PRM after radical hysterectomy in uterine cervical cancer correlates with poor prognosis even with CCRT. Therefore, additional treatments to improve local control such as radiation boosting need to be considered

  13. Radiotherapy combined with intracavitary irradiation for uterine cervical cancer. Study of survival rate, patterns of recurrence and complication

    International Nuclear Information System (INIS)

    Survival rates and patterns of recurrence in 137 patients with uterine cervical cancer were determined. These patients were treated by radiotherapy with high-dose rate intracavitary irradiation using remote afterloading system (RALS) at Kyorin University Hospital from Oct. 1987 to Dec. 1992. Age range was from 29 to 87 years. According to clinical staging of UICC, stages I, II, III, and IV were observed in 29, 62, 33, and 13 cases respectively. Cumulative 5-year survival rate of all cases was 72%. Cumulative 5-year survival rates were 100% for stage I, 81% for stage II, 38% for stage III, and 27% for stage IV. Cumulative 5-year survival rates of the postoperative radiotherapy and radical radiotherapy groups were 75% and 90% respectively. There was significant difference of survival rates between the postoperative radiotherapy group and the radical radiotherapy group. As patterns of recurrence, extrapelvic metastasis was more frequent than local recurrence. In stages II and III, recurrent patterns were extrapelvic matastasis in most cases. Of 18 cases with extrapelvic metastasis, there were 10 cases of paraaortic lymph node metastasis. With increase in the control rate of parraortic lymph node metastasis, survival rate of patients with uterine cervical cancer increased. Four of 5 cases with local recurrence controled by intracavitary irradiation is effective for local recurrence control. Rectal and bladder complications following radiotherapy were observed in 25 cases. However, all cases with complication after radiotherapy were treated conservatively, excluding 1 case (vasicorectal fistula). (author)

  14. Uterine Cancer Statistics

    Science.gov (United States)

    ... Research AMIGAS Fighting Cervical Cancer Worldwide Stay Informed Statistics for Other Kinds of Cancer Breast Cervical Colorectal ( ... Skin Vaginal and Vulvar Cancer Home Uterine Cancer Statistics Language: English Español (Spanish) Recommend on Facebook Tweet ...

  15. Tumor volume and uterine body invasion assessed by MRI for prediction of outcome in cervical carcinoma treated with concurrent chemotherapy and radiotherapy

    International Nuclear Information System (INIS)

    The aim of this study was to evaluate the prognostic significance of primary tumor volume and uterine body invasion assessed by pre-treatment MRI for uterine cervical cancer patient treated with concurrent chemotherapy and radiotherapy. A retrospective analysis of 106 patients with IB-IIIB cervical carcinoma was performed. Potential prognostic factors were stage, clinical tumor diameter, histology, age, pelvic lymph node, vaginal extension, parametrial invasion, tumor volume and uterine body invasion status. Multivariate analyses were performed to identify the prognostic factor for overall survival (OS) and disease-free survival (DFS). The 5-year OS, DFS rate were 59.7 and 56.6%. Using multivariate analyses, a large tumor volume (?30 ml; P=0.012) and uterine body invasion (P=0.020) and positive pelvic lymph node (LN) enlargement (P=0.040) showed a significantly unfavorable influence on OS. Using these three factors, patients were divided into four subgroups: the OS rates of patients with risk 0 (volume<30 ml, no uterine body invasion, and negative LN), risk 1 (one of these three factors), risk 2 (two of these three factors) and risk 3 (volume?30 ml, uterine body invasion, and positive LN) were 96.3, 77.5, 53.0 and 14.8%, respectively (P<0.0001). Tumor volume and uterine body invasion determined by MRI were significant prognostic factors for patients with cervical carcinoma. Pelvic lymph node enlargement diagnosed by CT also proved to be a significant prognostic factor in OS. Using these three parameters, we devised a practical and effective model to predict OS. (author)

  16. Neoadjuvant Intra-Arterial Chemotherapy for Locally Advanced Uterine Cervical Cancer: Clinical Efficacy and Factors Influencing Response

    International Nuclear Information System (INIS)

    Purpose: To evaluate the effects of neoadjuvant intra-arterial chemotherapy (NAIC) for locally advanced uterine cervical cancer, and to analyze factors influencing the response to the chemotherapy. Methods: Thirty-four patients with invasive cervical cancer more than 4 cm in diameter were enrolled in this study. NAIC was performed using cisplatin-based regimens. The response was assessed by magnetic resonance imaging (MRI) and examination of surgical specimens. Pretreatment factors involved in the response to NAIC were evaluated and the relationship between the factors and the prognosis was assessed. Results:Clinical response was achieved in 28 (82%) patients. Thirty-one of 49 invasions in the parametrial halves disappeared. Seventeen of 28 lymphnode swellings responded to NAIC. Six of the 14 stage III patients became operable. In the 19 surgical cases, pathologically complete responses were found in four. Twenty-eight of the 38 parametrial halves were free from cancer. No lymph node metastases were found in eight patients. Initial tumor volume was found to be an independent, significant determining factor of the response to NAIC. Patients with initial tumor volumes less than 80 cm3 had a significantly better estimated 5-year disease-free survival rate compared with those with larger tumors. Conclusion: NAIC for locally advanced cervical cancer is useful for preoperative tumor reduction.Tumor volume is a significant determining factor for the response to NAIC

  17. Cerebellar metastases in patients with uterine cervical cancer. Two cases reports and review of the literature; Metastases cerebelleuses chez des patientes atteintes d'un cancer du col uterin. A propos de deux cas et revue de la litterature

    Energy Technology Data Exchange (ETDEWEB)

    El Omari-Alaoui, H.; Gaye, P.M.; Kebdani, T.; El Ghazi, E.; Benjaafar, N.; Mansouri, A.; Errihani, H.; Kettani, F.; El Ouahabi, A.; El Gueddari, B.K. [Institut National d' Oncologie, Service de Radiotherapie, Rabat (Morocco)

    2003-10-01

    Brain metastases from cervical cancer are extremely rare. We report on two patients who developed cerebellar metastases following uterine cervical cancer. The interval between diagnosis of the primary cancer and diagnosis of brain metastasis was 8 months. The main complaint was symptoms of increased intracranial pressure and cerebellar syndrome. Surgical excision of the brain lesion followed by radiation therapy was performed in the first case. The second patient received palliative radiation therapy. The first patient died 8 months after diagnosis. The second patient is alive 2 months after diagnosis. (authors)

  18. Effects of radiotherapy combined with daily intramuscular injection of bleomycin for uterine cervical cancer

    International Nuclear Information System (INIS)

    A total of 103 cases of cancer of the uterine cervix, untreated previously, were treated with radiotherapy combined with daily intramuscular injection of Bleomycin 30 minutes before irradiation (BR therapy) in 12 institutions. Result showed that especially in cases of stage III, BR therapy was superior in primary local control rate (89.6%), recurrence rate (20.8%) and crude 5-year survival rate (56.5%) to that of nationwide statistics. No severe side effects were found. It was concluded that external radiotherapy could control advanced cancers of uterine cervix combining with intramuscular injection of Bleomycin. (author)

  19. Local lymphocytes and nitric oxide synthase in the uterine cervical stroma of patients with grade III cervical intraepithelial neoplasia

    Scientific Electronic Library Online (English)

    Cléber Sergio da, Silva; Marcia Antoniazi, Michelin; Renata Margarida, Etchebehere; Sheila Jorge, Adad; Eddie Fernando Candido, Murta.

    Full Text Available OBJECTIVES: Precancerous and cancerous cells can trigger an immune response that may limit tumor development and can be used as a prognostic marker. The aims of the present study were to quantify the presence of B and T lymphocytes, macrophages and cells expressing inducible nitric oxide synthase (i [...] NOS) in the cervical stroma of women with grade III cervical intraepithelial neoplasia (CIN III) or in the intratumoral and peritumoral tissue of women with stage I invasive carcinoma. METHODS: Cervical tissue specimens were obtained from 60 women (20 each from control tissues, CIN III and invasive carcinomas). The average ages in the control, CIN III and invasive groups were 43.9 (± 4.3), 35.5 (± 9.5), and 50 (± 11.2) years, respectively. The specimens were immunohistochemically labeled with antibodies to identify T lymphocytes (CD3), cytotoxic lymphocytes (CD8), B lymphocytes (CD20), macrophages (CD68) and iNOS. We evaluated the markers in the stroma above the squamocolumnar junction (control), at the intraepithelial lesion (CIN cases), and in the nfiltrating tumor. Two independent observers performed the immunohistochemical analysis. RESULTS: T lymphocytes, B lymphocytes, macrophages and iNOS were present more frequently (P

  20. Long-term outcomes of intracavitary hyperthermia in combination with radiotherapy for locally advanced uterine cervical cancer

    International Nuclear Information System (INIS)

    Objective: To evaluate the long-term clinical efficacy and toxicities of combined intracavitary hyperthermia and radiotherapy for locally advanced uterine cervical cancer. Methods: 310 patients with locally advanced uterine cervical cancer were assigned into intracavitary hyperthermia + radiotherapy group(TRT, 181 patients) and external-beam radiotherapy + traditional intracavitary radiation group (RT,129 patients). The external-beam radiotherapy were given with 60Co ?-ray or 6-8 MV X-ray in traditional fractionation. In TRT group, radiotherapy was 40 Gy using the anterior-posterior pelvic fields and additional 20-25 Gy using the lateral fields. Hyperthermia was delivered by the 915 MHz microwave hyperthermia device within 15-60 min after external radiotherapy for 10-12 times(40 min each time, 1-2 times per week). The temperature of tumor surface was 46-47 degree C. In the RT group, the external-beam radiotherapy of 40 Gy was delivered using the anterior-posterior pelvic fields. The intracavity radiotherapy of radium was delivered before 1989, with 50 mg radium in the vagina and 30 mg in uterine cavity for 24 hours, weekly for 3 times to a total dose of 7200 mg·h. After 1989, intracavity radiotherapy of 192Ir was delivered to a total dose of 30-36 Gy to point A in 5-6 Gy fractions, 2 fractions per week. Results: The 5-year survival of patients in TRT group and RT group was 67.4% versus 52.1% for stage II disease (?2=7.55, P=0.006), and 60.0% versus 32.3% for stage III (?2=7.06, P=0.007). The 10-year survival was 46.5% versus 42.6% for stage II (?2=3.90, P=0.058), and 43.7% versus 20.6% for stage III (?2=17.28, P=0.000). Cox regression analysis showed that the tumor stage(P=0.023) and intracavitary hyperthermia (P=0.019) were prognostic factors. According to the RTOG criteria, the rate of mild to moderate late side effects of rectum and bladder in TRT and RT group was 17.7% and 33.1%, respectively (?2=9.18, P=0.002). Rectovaginal fistula was developed in 5 patients (3.9%) in RT group and 1 patient (0.6%) in TRT group (?2= 4.38,P=0.036). Conclusions: The long-term survival of patients with stage III uterine cervical cancer is better of TRT group than RT group. The TRT is well tolerated and the late toxicity rate is obviously low. it is necessary to carry out large randomized clinical trials to confirm these outcomes. (authors)

  1. A case of radiation-induced cutaneous angiosarcoma 15 years after simultaneously occurring uterine cervical and gastric cancers discovered by autopsy

    International Nuclear Information System (INIS)

    A case of cutaneous angiosarcoma in the skin on the left hip previously irradiated for cervical uterine squamous cell carcinoma is discovered by autopsy. The patient, a 79-year-old woman, at age 64 had been then underwent radiotherapy for the cervical uterine carcinoma. A total dose of 50 Gy was administrated. At 79 years of age, she noticed multiple purple black nodular skin lesions on the left hip and thigh. She was hospitalized for 8 days, but her general condition rapidly deteriorated and she died. An autopsy revealed that the skin lesion was composed of atypical polygonal cell proliferation forming irregularly anastomosing vascularity, together with hemorrhage and necrosis. The tumor cells were positive for both CD34 and factor 8-related antigens. The final diagnosis was angiosarcoma. (author)

  2. The value of prognostic factors for uterine cervical cancer patients treated with irradiation alone

    International Nuclear Information System (INIS)

    The aim of our study was to investigate and evaluate the prognostic value of and correlations between preclinical and clinical factors such as the stage of the disease, blood Hb level before treatment, size of cervix and lymph nodes evaluated by CT, age, dose of irradiation and duration of radiotherapy related to overall survival, disease-free survival, local control and metastases-free survival in cervical cancer patients receiving radiotherapy alone. 162 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIA-IIIB cervical carcinoma treated with irradiation were analysed. Univariate and multivariate analyses using the Cox regression model were performed to determine statistical significance of some tumor-related factors. The Hb level before treatment showed significant influence on overall survival (p = 0.001), desease free survival (p = 0.040) and local control (p = 0.038). The lymph node status (>10 mm) assessed on CT had impact on overall survival (p = 0,030) and local control (p = 0,036). The dose at point A had impact on disease free survival (p = 0,028) and local control (p = 0,021) and the radiotherapy duration had showed significant influence on overall survival (p = 0,045), disease free survival (p = 0,006) and local control (p = 0,033). Anemia is a significant and independent prognostic factor of overall survival, disease-free survival and local control in cervical cancer patients treated with irradiation. The size of lymph nodes in CT is an independent prognostic factor for overall survival and local control in cervical cancer patients. The size of cervix uteri evaluated by CT has no prognostic significance in cervical cancer patients treated with radiotherapy. The prognostic value of FIGO stage of cervical cancer is influenced by other factors, analyzed in this study and is not an independent prognostic factor

  3. Comparison of dose–volume analysis between standard Manchester plan and magnetic resonance image-based plan of intracavitary brachytherapy for uterine cervical cancer

    OpenAIRE

    Takenaka, Tadashi; Yoshida, Ken; Tachiiri, Seiji; Yamazaki,, Hideya; Aramoto, Kazumasa; Furuya, Seiichi; Yoshida, Mineo; Ban, Chiaki; Tanaka, Eiichi; Honda, Kazuya

    2012-01-01

    To investigate the feasibility of image-based intracavitary brachytherapy (IBICBT) for uterine cervical cancer, we evaluated the dose–volume histograms (DVHs) for the tumor and organs at risk (OARs) and compared results from the IBICBT plan and the standard Manchester system (Manchester plan) in eight patients as a simulation experiment. We performed magnetic resonance imaging (MRI) and computed tomography (CT) following MRI-adapted applicator insertion, then superimposed MR images on the pla...

  4. 30 years of preventive studies of uterine cervical cancer 1982-2012

    Directory of Open Access Journals (Sweden)

    Garrido JL

    2014-10-01

    Full Text Available Purpose: To show and describe the clinical evolution of cervical cancer screening patients following the protocol established by the University of Padua. Methods: 12,679 patients were examined using Pap smear, colposcopy and biopsy in cases it was required. Results: From these large group of patients, 6,411 were diagnosed as patients at risk of developing cancer, from which 4,257 only had HPV infection, 1,150 had dysplastic lesions, 210 had cervical cancer and 794 cases were classified as simple oncogenic risk.

  5. Apparent rarity of asymptomatic herpes cervicitis in a woman with intra-uterine contraceptive device

    Directory of Open Access Journals (Sweden)

    Adeola Fowotade

    2013-12-01

    Full Text Available Infection with genital herpes simplex virus (HSV remains a common viral sexually transmitted disease, often subclinical and a major worldwide problem of women of reproductive age group. Herpes cervicitis is an unusual presentation of Herpes simplex virus infection in females. The finding of herpes cervicitis on routine pap smear of an asymptomatic woman on Intrauterine contraceptive device still further supports the need for increased awareness on the possibility of Herpes simplex virus infection among women, particularly those on Intrauterine contraceptive device. The index case is a 28 years old Nigerian female who was referred to our Special Treatment Clinic on account of an abnormal pap smear cytology which was in keeping with Herpes cervicitis. There was no history of genital ulcer in this patient; however ELISA for HSV 2 IgM was positive in her. We therefore describe a case of herpes cervicitis in an asymptomatic woman on intrauterine contraceptive device. This case highlights to clinicians the need to be aware of the possibility of this association and to carry out relevant investigations so as to identify and treat these patients appropriately. Therefore, there is a need to put in place adequate public health intervention strategy to prevent genital herpes in women of reproductive age group with a view to preventing the possibility of congenital herpes in subsequent pregnancy.

  6. A study for diagnosis of uterine cervical carcinoma with squamous cell carcinoma antibody

    International Nuclear Information System (INIS)

    In the past few decades, the presence of tumor-associated antigens has been demonstrated for several human neoplasms. In addition, recent developments in methods of radioimmunoassay have made it possible to detect low antigenic activity. The SCC demonstrated by Kato et al. has been reported to be specific for cervical squamous cell carcinoma. In addition, serial determinations of SCC may provide a useful method for evaluating regression or progression of disease. Another value of SCC in predicting the extent and prognosis has been suggested. From May, 1985. to July 1985. the SCC test were performed in 27 patients with histologically proven diagnosis. And changes of antigenic activities according to the chemotherapy were check only in 2 cases. Results are as follows: 1. 9 of 13 patients(69.2) with cervical squamous cell carcinoma showed positivity. 2. None of 6 control group without malignancy showed positivity. 3. Only three of eight patient with squamous cell carcinoma but cervical squamous cell carcinoma (37.5%) showed negativity. 4. Among the 13 patients with cervical squamous cell carcinoma, 2 of 4 patients with CIS(50%) were positive, 2 of 2 stage II patients(100%) were positive, 4 of 4 stage III or IV patients(100%) were positive and 1 of 3 recurrent cervical carcinoma patients(33.3%) was positive. The means of SCC antigen activities were 1.8 ng/ml, 20.5 ng/ml, 40.8 ng/ml, and 6.0 ng/ml, respectively. 5. 2 of 5 patients with bronchogenic carcinoma (40%) were positive, 2 patients with vaginal carcinoma(100%) were both positive, 1 patients with right ovarian tumor was positive. The means of SCC antigen activities were 2.8 ng/ml, 7.1 ng/ml and 4.9 ng/ml, respectively. 6. 2 patients(cervical carcinoma patient and vaginal carcinoma patient) were checked repeatedly according to chemotherapy. The titer of the patient with cervical carcinoma was decreased from 4.1 ng/ml to 1.9 ng/ml and that of the patient with vaginal carcinoma was also decreased from 6.1 ng/ml to 1.1 ng/ml. (Author)

  7. El cáncer cervicouterino y las lesiones precursoras: revisión bibliográfica / Cervical-uterine cancer and precursor lesions: a literature review

    Scientific Electronic Library Online (English)

    José Guillermo, Sanabria Negrín; Zoila C, Fernández Montequín; Inalvis de la Caridad, Cruz Hernández; Leonardo Oriolo, Pérez; Margarita, Llanuch Lara.

    2011-12-01

    Full Text Available Con el objetivo de actualizar el estado del arte sobre el cáncer cervicouterino y las lesiones precursoras se realizó una revisión bibliográfica de los artículos publicados en los últimos 5 años, y de otros originales teniendo en cuenta su nivel de evidencia médica I - II. Se utilizaron los buscador [...] es de la biblioteca Cochrane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, J Clinical Oncology, Medscape, PubMed, PubMed Central y artículos de la Agencia Internacional del Cáncer de Francia. Se revisaron los siguientes aspectos: Definiciones, epidemiología, etiología, factores de riesgo, citología, colposcopia, histopatología, clasificaciones, estadios clínicos, tratamientos, prevención, promoción de salud y problemas sociales. El cáncer cervicouterino es una enfermedad prevenible y curable, multifactorial, trasmitida sexualmente por el Virus del Papiloma Humano, con alta incidencia y prevalencia, y a pesar de los programas de pesquisaje continúa siendo un problema de salud. Se necesita de monitoreo permanente del programa de detección precoz en todos los ámbitos y alternativas de pesquisaje, adecuadas localmente a las necesidades, y de fuertes prevención y tratamiento para poder disminuir la carga social y económica que de este problema se derivan. Abstract in english Aimed at knowing the state of the art of cervical-uterine cancer and precursor lesions a literature review was carried out supported on the articles published in the last five years and from other original sources considering the levels I-II of medical evidences. Health information sources from Coch [...] rane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, Journal of Clinical Oncology, Medscape, PubMed, Central PubMed and French International Cancer Agency were used to revise the following aspects: definitions, epidemiology, etiology, risk factors, cytology, colposcopy, histopathology, classifications, clinical stages, treatments, prevention, health promotion and social problems. Cervical-uterine is a preventable, curable and multifactorial disease that is sexually transmitted by Human Papilloma Virus, presenting a high incidence and prevalence. Despite continuing screening programs, it is a health problem. Permanent monitoring programs to the early detection of this entity from all scopes must be carried out, along with screening alternatives that should be adjusted to the local needs, as well as the design of prevention and treatment programs to reduce social and economic burden resulting from this health problem.

  8. El cáncer cervicouterino y las lesiones precursoras: revisión bibliográfica Cervical-uterine cancer and precursor lesions: a literature review

    Directory of Open Access Journals (Sweden)

    José Guillermo Sanabria Negrín

    2011-12-01

    Full Text Available Con el objetivo de actualizar el estado del arte sobre el cáncer cervicouterino y las lesiones precursoras se realizó una revisión bibliográfica de los artículos publicados en los últimos 5 años, y de otros originales teniendo en cuenta su nivel de evidencia médica I - II. Se utilizaron los buscadores de la biblioteca Cochrane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, J Clinical Oncology, Medscape, PubMed, PubMed Central y artículos de la Agencia Internacional del Cáncer de Francia. Se revisaron los siguientes aspectos: Definiciones, epidemiología, etiología, factores de riesgo, citología, colposcopia, histopatología, clasificaciones, estadios clínicos, tratamientos, prevención, promoción de salud y problemas sociales. El cáncer cervicouterino es una enfermedad prevenible y curable, multifactorial, trasmitida sexualmente por el Virus del Papiloma Humano, con alta incidencia y prevalencia, y a pesar de los programas de pesquisaje continúa siendo un problema de salud. Se necesita de monitoreo permanente del programa de detección precoz en todos los ámbitos y alternativas de pesquisaje, adecuadas localmente a las necesidades, y de fuertes prevención y tratamiento para poder disminuir la carga social y económica que de este problema se derivan.Aimed at knowing the state of the art of cervical-uterine cancer and precursor lesions a literature review was carried out supported on the articles published in the last five years and from other original sources considering the levels I-II of medical evidences. Health information sources from Cochrane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, Journal of Clinical Oncology, Medscape, PubMed, Central PubMed and French International Cancer Agency were used to revise the following aspects: definitions, epidemiology, etiology, risk factors, cytology, colposcopy, histopathology, classifications, clinical stages, treatments, prevention, health promotion and social problems. Cervical-uterine is a preventable, curable and multifactorial disease that is sexually transmitted by Human Papilloma Virus, presenting a high incidence and prevalence. Despite continuing screening programs, it is a health problem. Permanent monitoring programs to the early detection of this entity from all scopes must be carried out, along with screening alternatives that should be adjusted to the local needs, as well as the design of prevention and treatment programs to reduce social and economic burden resulting from this health problem.

  9. Uterine cervical melanoma presenting with rapid progression detected by PET/CT

    International Nuclear Information System (INIS)

    Malignant melanoma of the uterine cervix is a rare extracutaneous melanoma which develops aggressively and is associated with a bleak prognosis. To our knowledge, no prior published reports have discussed the role of 18F-FDG positron emission tomography/computed tomography (PET/CT) in managing this disease. Our case study involved a 66-year-old woman with a malignant melanoma of the uterine cervix. The patient received PET/CT that identified metastases and lesions which had not been detected from her MRI. Serial PET/CT elucidated that the disease was initially limited to the pelvis, but then metastasized to the abdominal para-aortic lymph nodes, followed by extensive metastases to the brain, lungs, breast, supraclavicular, neck, and other abdominal lymph nodes, as observed at 6-month follow-up. PET/CT was used to complement conventional anatomic imaging modalities, and provided a novel modality for whole body screening. Visualization of the metabolic activity of indeterminate lesions may help in staging, re-staging, treatment planning, and prognostic prediction for patients with this rare disease

  10. Three cases of colorectal cancer after radiotherapy for the uterine cervical cancer

    International Nuclear Information System (INIS)

    Three cases of colorectal cancer that developed after radiotherapy for cervical cancer are reported. In all cases. the pathology of the initial cancers was squamous cell carcinoma, while that of the second cancer was adenocarcinoma. The latency period was more than 5 years in each case. There was no significant difference between observed number and expected number in the incidences of colorectal cancer. Long-term follow-up procedures are necessary because radiation may contribute to the induction of colorectal cancer. (author)

  11. Role of Sentinel Lymph Node in Early Stage of Uterine Cervical Cancer

    Directory of Open Access Journals (Sweden)

    Mihaela M?d?lina Gavrilescu

    2014-07-01

    Full Text Available Cervical cancer is currently the second most common form of neoplasia worldwide and third in the female population. Dissemination can occur directly (isthmus, parametrium, vagina, urinary bladder and/or rectum, through the lymphatic system (parametrium, internal iliac, external iliac, common iliac, obturator lymph nodes and rarely in the inferior gluteus, superior gluteus, superior rectum, sacrum, aortic lymph nodes and through the circulatory system (lung, mediastinum, bones, liver. The risk of pelvic lymph nodes invasion in stage IB (FIGO is 9-17%. The standard surgical treatment, for stages IA2-IIA, is radical hysterectomy with pelvic lymphadenectomy. The risk of intraoperative (vessel or nerve damage or postoperative complications (lymphedema is not negligible. The sentinel node concept refers to the first lymph node in which the cancerous lymphatic drainage takes place. This idea has radically changed the therapeutic approach in the treatment of breast cancer and melanoma. In cervical cancers, this technique is 92% accurate with only an 8% false negative rate. Currently, the sentinel node protocol is not included in the standard treatment for cervical cancer because certain issues need to be addressed (the sensitivity of the frozen section examination, the pathologist’s subjectivity, the uniformity of the protocol, the surgical experience, the size of the tumor.

  12. Sonoporation of Cervical Carcinoma Cells Affected with E6-Oncoprotein for the Treatment of Uterine Cancer

    Science.gov (United States)

    Curiel, Laura; Lee, Kyle; Pichardo, Samuel; Zehbe, Ingeborg

    2010-03-01

    Cervical cancer has been identified as the third leading cause of average years of life lost per person dying of cancer. Since essentially all cervical cancers contain copies of human papillomavirus (HPV) DNA, we propose a treatment that targets HPV-infected cells using strategies that re-introduce normal functions into the infected cells while sparing healthy cells. We propose the use of focused ultrasound in combination with microbubbles as means to deliver antibodies against the E6 protein present only in HPV positive cells. We conducted in vitro studies with cell cultures of SiHa cervical carcinoma cells seeded into Opticell™ chambers. An in-house ultrasound excitation apparatus was used to control and explore the optimal acoustic parameters in order to maximize delivery. We first validated the possibility of delivering the EX-EGFP-M02 vector (Genecopoeia) into the cells; 1.2 ?L of activated microbubbles (Definity®) and 50 ?g of the vector were mixed in media and then injected into the Opticell™ chamber. We used 32 ?s pulses at a central frequency of 930 KHz with a repetition frequency of 1.5 kHz and total exposure duration of 30 s; six pressure values were tested (0 to 1 MPa). Fluorescence imaging was used to determine the levels of intracellular proteins and assess delivery. The delivery of an anti-?-Tubulin antibody was next tested and confirmed that the delivery into HPV16 positive cells was successful.

  13. A consensus-based guideline defining clinical target volume for primary disease in external beam radiotherapy for intact uterine cervical cancer

    International Nuclear Information System (INIS)

    The objective of this study was to develop a consensus-based guideline to define clinical target volume for primary disease (clinical target volume primary) in external beam radiotherapy for intact uterine cervical cancer. The working subgroup of the Japan Clinical Oncology Group (JCOG) Radiation Therapy Study Group began developing a guideline for primary clinical target volume in November 2009. The group consisted of 10 radiation oncologists and 2 gynecologic oncologists. The process started with comparing the contouring on computed tomographic images of actual cervical cancer cases among the members. This was followed by a comprehensive literature review that included primary research articles and textbooks as well as information on surgical procedures. Extensive discussion occurred in face-to-face meetings (three occasions) and frequent e-mail communications until a consensus was reached. The working subgroup reached a consensus on the definition for the clinical target volume primary. The clinical target volume primary consists of the gross tumor volume, uterine cervix, uterine corpus, parametrium, vagina and ovaries. Definitions for these component structures were determined. Anatomical boundaries in all directions were defined for the parametrium. Examples delineating these boundaries were prepared for the posterior border of the parametrium for various clinical situations (id est (i.e.) central tumor bulk, degree of parametrial involvement). A consensus-based guideline defining the clinical target volume primary was developed for external beam radiotherapy for intact uterine cervical cancer. This guideline will serve as a template for radiotherapy protocols in future clinical trials. It may also be used in actual clinical practice in the setting of highly precise external beam radiotherapy, including intensity-modulated radiotherapy. (author)

  14. Optimal overall treatment time in fractionated radiotherapy for head and neck cancers, esophageal cancer, and uterine cervical cancer

    International Nuclear Information System (INIS)

    The effects of overall treatment time (OTT) on local control of radiation therapy (RT) were evaluated to consider optimal OTT in RT. Local control probabilities and acute and late toxicities of esophageal cancer (Stages I-III), glottic laryngeal cancer (Stage I), and uterine cervical cancer (Stage III) treated at Kyoto University Hospital and its affiliated hospitals were analyzed in relation to OTT. For these tumors, local control probabilities decreased when OTT increased. In the multivariate analyses for esophageal cancer and laryngeal cancer, OTT was a significant variable for local control. Only a 1-week interruption of RT due to holidays resulted in a significant reduction of local control probability for T1 glottic tumors. On the other hand, there was no significant difference in local control rates between OTT of 4 weeks and 6 weeks for esophageal cancer. For complications, acute and late toxicities increased when OTT was reduced by accelerated hyperfractionated RT for esophageal cancer. In conclusion, OTT should be kept as short as possible within the limits of tolerance of normal tissues and the patients. We consider that RT must be delivered in the range of 66 to 70 Gy in 6 weeks to obtain optimal local control with minimum complications. (author). 52 refs

  15. Knowledge, attitudes and practices on cervical cytology-uterine in women from sincelejo and Cartagena, colombia

    Directory of Open Access Journals (Sweden)

    Barrrios-Garcia Lia

    2011-12-01

    Full Text Available Although in Colombia screening programs of cervical cancer have achieved high levelsof coverage, cervical cancer has the first places in incidence and mortality. There isthe need to identify factors influencing it, among them is to investigate the level ofawareness of women about the screening test, their attitudes to screening and itspractices. For this we made a survey of 505 women 13 to 60 years who have had sexual life, living in the cities of Cartagena and Sincelejo (Colombia.The results showthat virtually all women have knowledge of cervical cytology, 94.5% of women havemade at least once. This percentage is higher in the range of 40 to 60 years where itreaches 99% in younger women this percentage decrease. In defining its usefulness,only 73.8% responded accurately. 50% reported unpleasant aspects related to themaking of the cytology, such as fear, and fear of a cancer diagnosis. A fail to rememberis the main factor for not claiming the results.These data show that the percentage ofwomen with sexual life that ignores the usefulness of cytology or never have practicedis minimal, which leads to the conclusion that ineffective screening programs to reducecervical cancer rates depends on other factors that should be investigated.RESUMEN:Aunque en Colombia los programas de prevención del cáncer de cérvix han alcanzadoaltos niveles de cobertura, todavía este ocupa los primeros lugares en incidencia ymortalidad. Existe la necesidad de identificar los factores que influyen en ello, por tantoes importante investigar el nivel de conocimiento de las mujeres sobre la prueba detamizaje, su actitud frente a la misma y sus prácticas relacionadas. Se realizó encuestaa 505 mujeres entre 13 y 60 años edad, que habían tenido vida sexual, residentes en lasciudades de Cartagena y Sincelejo (Colombia. Los resultados revelan que prácticamentetodas las mujeres tienen conocimientos sobre citología cérvico-uterina. El 94.5% delas mujeres se la han realizado por lo menos una vez. Este porcentaje es mayor en elrango de 40 a 60 años donde alcanza el 99%, y en las de menor edad este porcentajedisminuye. Al definir su utilidad: solo el 73.8% respondió de manera acertada. El 50%refieren aspectos desagradables en relación con la toma de la citología, como el miedoy el temor a un diagnóstico de cáncer y el olvido es el principal factor para no reclamarlos resultados. Estos datos demuestran que el porcentaje de mujeres con vida sexualque desconocen la utilidad de la citología o nunca se la han practicado es mínimo, locual permite concluir que la ineficacia de los programas de tamizaje para disminuir lascifras de cáncer de cérvix en nuestro medio depende de otros factores que deben serevaluados.

  16. Uterine Sarcoidosis: A Rare Extrapulmonary Site of Sarcoidosis

    OpenAIRE

    Marak, Creticus P; Narendrakumar Alappan; Amit Chopra; Olena Dorokhova; Sumita Sinha; Achuta K. Guddati

    2013-01-01

    Sarcoidosis is a multisystem disease which is most commonly manifested in the pulmonary system. However, extrapulmonary manifestations have also been frequently reported. Isolated occurrence of sarcoidosis in the genital system is rare and poses a diagnostic and therapeutic dilemma. Uterine sarcoidosis can present with cervical erosions, endometrial polypoid lesions, and recurrent serometra. In majority of cases, it is diagnosed by endometrial curettage, but it has also been detected by exami...

  17. Uterine cervical cancer: treatment with megavoltage radiation results and afterloading intracavitary techniques

    International Nuclear Information System (INIS)

    Results were evaluated for 651 consecutive patients with invasive cancer of the intact uterine cervix. From 1963 through 1967 319 patients were treated primarily with the older Los Angeles County Hospital system of orthovoltage radiation and intracavitary radium therapy. Thereafter, 1968 to 1974, 332 patients were treated primarily with a newer modified M. D. Anderson Tumor Institute system of megavoltage radiation and afterloading intracavitary radium therapy. Age distribution and histology were similar for both groups, but clinical stage was slightly more advanced for patients treated earlier. Crude and net 5 year survival rates were 36% and 49% for the early group and 54% and 67% for the later group. Net 5 year survival rates for the earlier group by stage were: stage 1, 74%; II, 62%; III, 23%; and IV, 6%. Survival rates for the later group were: I, 81%; II, 76%; III, 50%; and IV, 15%. We believe this improvement can be attributed to more effective intracavitary radium therapy for handling local cancer and to delivery of cancericidal doses of radiation to regional nodes with the megavoltage radiation apparatus, as well as to the greater cooperative efforts put forth in the management of County Hospital patients

  18. Intracavitary radiotherapy with Cf-252 for uterine cervical carcinomas at the Japan Cancer Institute Hospital

    Energy Technology Data Exchange (ETDEWEB)

    Fukuda, F.; Masubuchi, K.; Kaneta, K.; Tsuya, A.; Irifune, I.; Onai, Y.

    1986-01-01

    Cf-252 intracavitary radiotherapy using a specially designed remote afterloading system and treatment facility was performed in patients with stage IIB and IIIB cervical carcinoma. Cf-252 was effective for both squamous cell carcinoma and adenocarcinoma. For stage IIB 7/7 (100%) had local control, 1/7 (14%) injury, and 6/7 (85%) had long term survival NED. For stage IIIB disease 3/11 (27%) had local control and long term survival. With the varying doses and treatment protocols used, complications were noted, mostly recto-sigmoid. Further study of Cf-252 use in cervix cancer and of its effect on the recto-sigmoid mucosa is required. Both local control and long-term survival (--5 year) were obtained using Cf-252 intracavitary therapy.

  19. Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer

    Science.gov (United States)

    Lyng, Heidi; Brøvig, Runar S; Svendsrud, Debbie H; Holm, Ruth; Kaalhus, Olav; Knutstad, Kjetil; Oksefjell, Halldis; Sundfør, Kolbein; Kristensen, Gunnar B; Stokke, Trond

    2006-01-01

    Background A better understanding of the development of metastatic disease and the identification of molecular markers for cancer spread would be useful for the design of improved treatment strategies. This study was conducted to identify gene expressions associated with metastatic phenotypes of locally advanced cervical carcinomas and investigate whether gains or losses of these genes could play a role in regulation of the transcripts. Gene expressions and copy number changes were determined in primary tumors from 29 patients with and 19 without diagnosed lymph node metastases by use of cDNA and genomic microarray techniques, respectively. Results Thirty-one genes that differed in expression between the node positive and negative tumors were identified. Expressions of eight of these genes (MRPL11, CKS2, PDK2, MRPS23, MSN, TBX3, KLF3, LSM3) correlated with progression free survival in univariate analysis and were therefore more strongly associated with metastatic phenotypes than the others. Immunohistochemistry data of CKS2 and MSN showed similar relationships to survival. The prognostic genes clustered into two groups, suggesting two major metastatic phenotypes. One group was associated with rapid proliferation, oxidative phosphorylation, invasiveness, and tumor size (MRPS23, MRPL11, CKS2, LSM3, TBX3, MSN) and another with hypoxia tolerance, anaerobic metabolism, and high lactate content (PDK2, KLF3). Multivariate analysis identified tumor volume and PDK2 expression as independent prognostic variables. Gene copy number changes of the differentially expressed genes were not frequent, but correlated with the expression level for seven genes, including MRPS23, MSN, and LSM3. Conclusion Gene expressions associated with known metastatic phenotypes of cervical cancers were identified. Our findings may indicate molecular mechanisms underlying development of these phenotypes and be useful as markers of cancer spread. Gains or losses of the genes may be involved in development of the metastatic phenotypes in some cases, but other mechanisms for transcriptional regulation are probably important in the majority of tumors. PMID:17054779

  20. RAPIDARC (RA) in the uterine cervical cancer; dosimetric gain vs 3D-Crt

    International Nuclear Information System (INIS)

    This work aims to quantitatively assess RAPIDARC (RA) treatments versus three dimensional-Conformal Radiation Therapy with field to field technique (3D-Crt-Fin F). 11 patients with cervical cancer treated at our institution radically or adjuvant clinical stages I-III B were evaluated. The prescribed dose was 50 Gy (2 Gy / Fr). The RA plans consisted of two isocentric complete arcs and conformational plans of 4 isocentric fields (previous, subsequent, right side and left side) with 3D-Crt-Fin F technique; both cases carried out ??in the Eclipse version 10 planner with calculation algorithm analytical anisotropic algorithm (AAA) and volumetric optimization software (for VMAT plans). Homogeneity indices (Hi), conformity indices (CI) Sigma indices (S-Index), monitor units (MU) and the time required for each treatment were compared. The mean age was 52 years (32-65) of the 11 patients 9 were clinical stages I-II B. The Hi varied from 0.052 for RA to 0.163 for 3D-Crt-Fin F (p = 0.009), and the CI between 1.005 and 1.35 (p = 0.26), the S-index from 1.2 to 3.7 (p = 0.001) and the H-index of 1.08 to 1.15 (p = 0.24). All dose limits in risk organs were met with a significant difference in the RA plans versus 3D-Crt-Fin F. In patients with cervical cancer the treatment plans quality with the indices aforementioned seems to be better with the RA technique, being observed a significant reduction of radiation to surrounding organs. (author)

  1. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... an excellent choice. Some women may not be candidates for this, and we'll get into that ... want to treat people with history of cervical cancer or uterine cancer. We have to make sure ...

  2. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... We don't want to treat people with history of cervical cancer or uterine cancer. We have ... bed. Tomorrow morning, she'll be home taking oral mediations to control her cramping. And within a ...

  3. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... OR Live bah 2777 show some short-term relief of her symptoms. Her symptoms have come back. ... We don't want to treat people with history of cervical cancer or uterine cancer. We have ...

  4. Melanosis of the uterine cervix: a case report and literature review / Melanose cervical uterina: relato de caso e revisão da literatura

    Scientific Electronic Library Online (English)

    Daniel, Chang; Gerusa Biagione, Tiburzio.

    2013-06-01

    Full Text Available A melanose cervical uterina representa lesão melanocítica extremamente rara, devendo ser diferenciada do melanoma. Trata-se de uma hiperpigmentação melanocítica das células da camada basal da mucosa escamosa do colo uterino sem aumento no número de melanócitos. Apresenta-se, neste artigo, um caso ca [...] racterístico dessa entidade, além da discussão acerca das possíveis origens dos melanócitos nessa região, bem como sua relação com a síndrome de Laugier-Hunziker e o complexo de Carney. Abstract in english Melanosis of the uterine cervix is an extremely rare melanocytic lesion and should be differentiated from melanoma. It is a melanocytic hyperpigmentation of basal layer cells from the squamous mucosa of the uterine cervix without an increase in the number of melanocytes. We present a typical case of [...] this entity. Furthermore, we discuss the possible origins of melanocytes in this region and their association with Laugier-Hunziker syndrome and Carney complex.

  5. Pre-invasive cervical disease and uterine cervical cancer in Brazilian adolescents: prevalence and related factors Doença cervical pré-invasiva e câncer cérvico-uterino em adolescentes brasileiras: prevalência e fatores associados

    Directory of Open Access Journals (Sweden)

    Denise Leite Maia Monteiro

    2006-12-01

    Full Text Available The objective was to describe the prevalence and factors associated with uterine cervical cancer (CA and high-grade squamous intraepithelial lesions (HSIL in adolescents. A cross-sectional study was carried out with 702 sexually active adolescents treated at a general hospital in Rio de Janeiro, Brazil, from 1993 to 2002. Screening was performed by cytopathology and colposcopy and confirmation by biopsy. Exposure variables were socio-demographic characteristics and those related to reproductive health, habits, and sexual behavior. Adjusted odds ratios were estimated using multivariate logistic regression analysis. Based on histopathology, the prevalence of HSIL/CA was 3% (95%CI: 1.8-4.6. There was one case of invasive cancer. With each additional pregnancy, the odds of HSIL/CA increased by 2.2 (95%CI: 1.1-4.4. Age was also associated with this outcome, doubling the odds of acquiring this degree of disease with each year of age (OR = 2.0; 95%CI: 1.2-3.4. The prevalence of lesions suggests the importance of including sexually active adolescent females in cervical cancer screening programs aimed at early detection and treatment of these lesions.O objetivo foi descrever a freqüência e os fatores associados ao câncer cervical (CA e lesões escamosas intra-epiteliais de alto grau (HSIL entre adolescentes. Realizou-se estudo transversal com 702 adolescentes sexualmente ativas, assistidas em um hospital geral no Rio de Janeiro, Brasil, entre 1993 e 2002. A investigação foi realizada através de citopatologia e colposcopia, e a confirmação por biópsia cervical. As variáveis de exposição foram características sociais e demográficas, e aquelas relacionadas à saúde reprodutiva, hábitos e comportamento sexual. Baseado nos achados histopatológicos, a freqüência de HSIL/CA foi 3% (IC95%: 1,8-4,6. Houve um caso de câncer invasivo. A cada nova gestação, a chance de HSIL/CA aumentava 2,2 vezes (IC95%: 1,1-4,4. A idade também esteve associada com este resultado (OR = 2,0; IC95%: 1,2-3,4, dobrando a cada ano de idade a chance de adquirir este nível da doença. A freqüência de lesões cervicais intra-epiteliais sugere a importância de incluir adolescentes sexualmente ativas nos programas de prevenção do câncer cervical, com o objetivo de detectar e assegurar o tratamento precoce destas lesões.

  6. The Results of Curative Radiation Therapy for 49 Patients of the Uterine Cervical Carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Mi Ryeong; Kim, Yeon Sil; Choi, Byung Ock; Yoon, Sei Chul; Shinn, Kyung Sub; Namkoong, Sung Eun; Kim, Seung Jo [Catholic University College of Medicine, Seoul (Korea, Republic of)

    1992-12-15

    Fifty patients with carcinoma of the uterine cervix received curative radiotherapy by external irradiation of the whole pelvis and intracavitary radiation at the Department of Therapeutic Radiology, Kangnam St. Mary Hospital from September,1983 to October, 1986. External beam whole pelvic irradiation was done first up to 4500-5940 cGy in 5 weeks to 6.5 weeks, followed by an intracavitary radiation. Total dose of radiation to point A varied from 6500 cGy to l1344 cGy (average 6764 cGy). Of the 50 patients, one patient was lost to follow up and follow up period of the remaining 49 patients ranged from 3 months to 93 months (median 32 months). According to FIGO classification, 6 (12.2%) were in stage I b, 6(12.2%) in stage I a, 25(51%) in stage II b, 7(14%) in stage III, and 5(10.2%) in stage IV. Age of the patients ranged from 33 to 76 years (Median 60 years). Pathologically, forty six(94%) patients had squamous cell carcinoma, 2 (4% had adenocarcinoma, and 1 (2%) had adenosquamous cell carcinoma. Overall response rate was 84%. 5-year survival rate was 49% for entire group (75% for stage I b, 83% for stage II a, 42.5% for stage II b, 25% for stage III, 40% for stage IV). Complications were observed in 11(22.4%) patients, who revealed rectal complications with most common frequency. Others were self limiting trifle ones such as wet desquamation, fatigue, mild leukopenia, etc. The correlation of the survival rate with various factors (age, dose, Hb level, pelvic lymph node status, performance status, local recurrence) was evaluated but showed no statistical significance except the age and local recurrence in this series; survival of patients less than 50 years of age was worse than that of the older, and the presence of local recurrence had worse prognosis(p< 0.05)

  7. Preoperative PET/CT FDG standardized uptake value of pelvic lymph nodes as a significant prognostic factor in patients with uterine cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Hyun Hoon [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea, Republic of); Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Seoul (Korea, Republic of); Cheon, Gi Jeong; Kang, Keon Wook [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul (Korea, Republic of); Kim, Jae Weon; Park, Noh-Hyun [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea, Republic of); Song, Yong Sang [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea, Republic of); Seoul National University, WCU Biomodulation Major, Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul (Korea, Republic of)

    2014-04-15

    Using integrated PET/CT, we evaluated the prognostic relevance in uterine cervical cancer of preoperative pelvic lymph node (LN) [{sup 18}F]FDG uptake. Patients with FIGO stage IB to IIA uterine cervical cancer were imaged with FDG PET/CT before radical surgery. We used Cox proportional hazards regression to examine the relationship between recurrence and the FDG maximum standardized uptake value (SUV{sub max}) in the pelvic LN (SUV{sub LN}) on PET/CT. Clinical data, treatment modalities, and results in 130 eligible patients were reviewed. The median postsurgical follow-up was 34 months (range 6 to 109 months). Receiver operating characteristic analysis identified SUV{sub LN} 2.36 as the most significant cut-off value for predicting recurrence. SUV{sub LN} was correlated with SUV{sub tumour} (P = 0.002), primary tumour size (P = 0.004), and parametrial invasion (P = 0.013). Univariate analyses showed significant associations between recurrence and SUV{sub LN} (P = 0.001), SUV{sub tumour} (P = 0.007), pelvic LN metastasis (P = 0.002), parametrial invasion (P < 0.001), primary tumour size (P = 0.007), suspected LN metastasis on MRI (P = 0.024), and FIGO stage (P = 0.026). Multivariate analysis identified SUV{sub LN} (P = 0.013, hazard ratio, HR, 4.447, 95 % confidence interval, CI, 1.379 - 14.343) and parametrial invasion (P = 0.013, HR 6.728, 95 % CI 1.497 - 30.235) as independent risk factors for recurrence. Patients with SUV{sub LN} ?2.36 and SUV{sub LN} <2.36 differed significantly in terms of recurrence (HR 15.20, P < 0.001). Preoperative pelvic LN FDG uptake showed a strong significant association with uterine cervical cancer recurrence. (orig.)

  8. Preoperative PET/CT FDG standardized uptake value of pelvic lymph nodes as a significant prognostic factor in patients with uterine cervical cancer

    International Nuclear Information System (INIS)

    Using integrated PET/CT, we evaluated the prognostic relevance in uterine cervical cancer of preoperative pelvic lymph node (LN) [18F]FDG uptake. Patients with FIGO stage IB to IIA uterine cervical cancer were imaged with FDG PET/CT before radical surgery. We used Cox proportional hazards regression to examine the relationship between recurrence and the FDG maximum standardized uptake value (SUVmax) in the pelvic LN (SUVLN) on PET/CT. Clinical data, treatment modalities, and results in 130 eligible patients were reviewed. The median postsurgical follow-up was 34 months (range 6 to 109 months). Receiver operating characteristic analysis identified SUVLN 2.36 as the most significant cut-off value for predicting recurrence. SUVLN was correlated with SUVtumour (P = 0.002), primary tumour size (P = 0.004), and parametrial invasion (P = 0.013). Univariate analyses showed significant associations between recurrence and SUVLN (P = 0.001), SUVtumour (P = 0.007), pelvic LN metastasis (P = 0.002), parametrial invasion (P LN (P = 0.013, hazard ratio, HR, 4.447, 95 % confidence interval, CI, 1.379 - 14.343) and parametrial invasion (P = 0.013, HR 6.728, 95 % CI 1.497 - 30.235) as independent risk factors for recurrence. Patients with SUVLN ?2.36 and SUVLN <2.36 differed significantly in terms of recurrence (HR 15.20, P < 0.001). Preoperative pelvic LN FDG uptake showed a strong significant association with uterine cervical cancer recurrence. (orig.)

  9. Pre-treatment diffusion-weighted MR imaging for predicting tumor recurrence in uterine cervical cancer treated with concurrent chemoradiation: Value of histogram analysis of apparent diffusion coefficients

    International Nuclear Information System (INIS)

    To evaluate the value of apparent diffusion coefficient (ADC) histogram analysis for predicting tumor recurrence in patients with uterine cervical cancer treated with chemoradiation therapy (CRT). Our institutional review board approved this retrospective study and waived informed consent from each patient. Forty-two patients (mean age, 56 ± 14 years) with biopsy-proven uterine cervical squamous cell carcinoma who underwent both pre-treatment pelvic magnetic resonance imaging with a 3.0 T magnetic resonance scanner and concurrent CRT were included. All patients were followed-up for more than 6 months (mean, 36.4 ± 11.9 months; range 9.0-52.8 months) after completion of CRT. Baseline ADC parameters (mean ADC, 25th percentile, 50th percentile, and 75th percentile ADC values) of tumors were calculated and compared between the recurrence and no recurrence groups. In the recurrence group, the mean ADC and 75th percentile ADC values of tumors were significantly higher than those of the no recurrence group (p = 0.043 and p = 0.008, respectively). In multivariate analysis, the 75th percentile ADC value of tumors was a significant predictor for tumor recurrence (p = 0.009; hazard ratio, 1.319). When the cut-off value of the 75th percentile ADC (0.936 x 10-3 mm2/sec) was used, the overall recurrence free survival rate above the cut-off value was significantly lower than that below the cut-off value (51.9% vs. 91.7%, p = 0.003, log-rank test). Pre-CRT ADC histogram analysis may serve as a biomarker for predicting tumor recurrence in patients with uterine cervical cancer treated with CRT.

  10. Do clinicians and patients agree regarding symptoms? A comparison after definitive radiochemotherapy in 223 uterine cervical cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Kirchheiner, K.; Poetter, R. [Medical Univ. Vienna (Austria). Dept. of Radiotherapy; Nout, R. [University Medical Center Leiden (Netherlands). Dept. of Clinical Oncology; Lindegaard, J. [University Hospital Aarhus (Denmark). Dept. of Oncology; Petric, P. [Institute of Oncology Ljubljana (Slovenia). Dept. of Radiotherapy; Limbergen, E.V. [University Hospital Leuven (Belgium). Dept. of Radiotherapy; Juergenliemk-Schulz, I.M. [University Medical Center Utrecht (Netherlands). Dept. of Radiation Oncology; Haie-Meder, C. [Institut Gustave-Roussy, Villejuif (France). Dept. of Radiotherapy; Doerr, W. [Technische Univ. Dresden (Germany). Dept. of Radiotherapy and Radiooncology

    2012-10-15

    Background: In clinical cancer research of morbidity, low associations between clinician-assessed toxicity/morbidity and patient-reported symptoms are consistently described in the literature. While morbidity grading systems are supposed to follow more or less objective criteria, patient reported symptoms inherently are based on a subjective self-evaluation of the impact on quality of life. The aim of this study was to focus on major discrepancies with high clinical relevance and to evaluate its impact with regard to underreporting of morbidity. Material and methods: Early morbidity assessed by clinicians with CTCAEv.3 and patient reported quality of life (EORTC-QLQ-C30/CX24) were compared regarding 12 overlapping symptoms in 223 patients with uterine cervical cancer 3 months after definitive radio(chemo)therapy in the ongoing EMBRACE study. Mismatches showing discrepancies between both grading systems were classified, if patients reported substantial symptoms (quite a bit/very much) and CTCAE grading was rated G0. Results: In total, 360 substantial symptoms were reported by patients by EORTC-QLQ; 159 (44%) of those were not recognized by CTCAE. Symptoms with the highest occurrence of mismatches overall are urinary frequency, fatigue, and insomnia. Large institutional differences were found, showing two centers with 4 vs. 71% of patients with at least one mismatch. Conclusion: Analysis of mismatches indicated a high risk of underestimation of early morbidity. Thus, nearly half of the patient-reported substantial symptoms were not recognized by CTCAE scoring (G0) 3 months after treatment. Prospective assessment of morbidity in clinical studies should, therefore, integrate patient reported symptoms to receive a complete and comprehensive picture. (orig.)

  11. Do clinicians and patients agree regarding symptoms? A comparison after definitive radiochemotherapy in 223 uterine cervical cancer patients

    International Nuclear Information System (INIS)

    Background: In clinical cancer research of morbidity, low associations between clinician-assessed toxicity/morbidity and patient-reported symptoms are consistently described in the literature. While morbidity grading systems are supposed to follow more or less objective criteria, patient reported symptoms inherently are based on a subjective self-evaluation of the impact on quality of life. The aim of this study was to focus on major discrepancies with high clinical relevance and to evaluate its impact with regard to underreporting of morbidity. Material and methods: Early morbidity assessed by clinicians with CTCAEv.3 and patient reported quality of life (EORTC-QLQ-C30/CX24) were compared regarding 12 overlapping symptoms in 223 patients with uterine cervical cancer 3 months after definitive radio(chemo)therapy in the ongoing EMBRACE study. Mismatches showing discrepancies between both grading systems were classified, if patients reported substantial symptoms (quite a bit/very much) and CTCAE grading was rated G0. Results: In total, 360 substantial symptoms were reported by patients by EORTC-QLQ; 159 (44%) of those were not recognized by CTCAE. Symptoms with the highest occurrence of mismatches overall are urinary frequency, fatigue, and insomnia. Large institutional differences were found, showing two centers with 4 vs. 71% of patients with at least one mismatch. Conclusion: Analysis of mismatches indicated a high risk of underestimation of early morbidity. Thus, nearly half of the patient-reported substantial symptoms were not recognized by CTCAE scoring (G0) 3 months after treatment. Prospective assessment of morbidity in clinical studies should, therefore, integrate patient reported symptoms to receive a complete and comprehensive picture. (orig.)

  12. Interfractional change of high-risk CTV D90 during image-guided brachytherapy for uterine cervical cancer

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate interfractional changes of the minimum dose delivered to 90% of the high-risk clinical target volume (HR-CTV D90) and D2cc of the bladder and rectum during brachytherapy for uterine cervical cancer patients. A total of 52 patients received external beam radiotherapy and high-dose-rate intracavitary brachytherapy (ICBT). For each of four ICBT applications, a pelvic CT scan was performed and the HR-CTV was delineated. Retrospectively, these patients were divided into two groups: (1) the standard dose group with 6 Gy to point A in each ICBT, and (2) the adaptive dose group with a modified dose to point A to cover the HR-CTV with the 6-Gy isodose line as much as possible. The HR-CTV D90 was assessed in every session, and analyzed as interfractional changes. In the standard dose group, the interfractional changes of the HR-CTV D90 showed a linear increase from the first to the third of the four ICBT (average 6.1, 6.6, 7.0 and 7.1 Gy, respectively). In contrast, those of the adaptive dose group remained almost constant (average 7.2, 7.2, 7.3 and 7.4 Gy, respectively). Especially, in the case of a large HR-CTV volume (?35 cm3) at first ICBT, the total HR-CTV D90 of the adaptive dose group with brachytherapy was significantly higher than that of the standard dose group. There were no significant differences in total D2cc in bladder and rectum between the two groups. Image-guided adaptive brachytherapy based on interfractional tumor volume change improves the dose to the HR-CTV while keeping rectal and bladder doses within acceptable levels. (author)

  13. Long time effect of combination therapy with irradiation and balloon-occluded arterial infusion of anti-cancer drugs on uterine cervical cancer

    International Nuclear Information System (INIS)

    Long time effect of combination therapy with irradiation and balloon-occluded arterial infusion (BOAI) of anti-cancer drugs on uterine cervical cancer was estimated by retrospective analysis. All 73 cases received radiotherapy, while 39 cases were treated also with BOAI. Cisplatin, adriamycin and pepleomycin were administered by BOAI. In 44 stage III cases, patients with BOAI showed significantly better 5-year survival compared to radiation alone group (p=0.045). Multivariate analysis selected stage, blood hemoglobin content and BOAI as significant predictor of prognosis. No increase of late radiation damage to rectum or to urinary bladder was seen by combination therapy with BOAI. (author)

  14. The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix

    DEFF Research Database (Denmark)

    Hariri, Jalil; Øster, Anne

    2007-01-01

    The immunohistochemical expression of p16 in formalin-fixed and paraffin-embedded histological sections was evaluated in a retrospective study comprising a low-grade group of 100 cases of cervical intraepithelial neoplasia (CIN) 1, a high-grade group of 50 cases of CIN 2 to 3, and a benign group of 50 cases of normal tissue or benign lesions in the uterine cervix. The cases were consecutive within each group and had a minimum follow-up period of 5 years. Positive reaction for p16 was detected in...

  15. Undetected human papillomavirus DNA and uterine cervical carcinoma. Association with cancer recurrence

    International Nuclear Information System (INIS)

    The time course of human papillomavirus (HPV) DNA clearance was studied in patients with carcinoma of the cervix during follow-up after primary radical radiotherapy (RT). This study investigated the relationship between timing of HPV clearance and RT effectiveness. A total of 71 consecutive patients who were treated for cervical cancer with primary radical radiotherapy and high-dose rate intracavitary brachytherapy with or without chemotherapy were enrolled in the study. Samples for HPV DNA examination were taken before (1) treatment, (2) every brachytherapy, and (3) every follow-up examination. The times when HPV DNA was undetected were analyzed for association with recurrence-free survival. HPV DNA was not detected in 13 patients (18 %) before RT. Of the 58 patients with HPV DNA detected before treatment, HPV DNA was not detected in 34 % during treatment and in 66 % after the treatment. Within 6 months after RT, HPV DNA was detected in 0 % of all patients. The patients were followed up for a median period of 43 months (range 7-70 months). In all, 20 patients were found to develop recurrence. The 3-year cumulative disease-free survival (DFS) rate was 71 ± 5.4 % for all 71 patients. In multivariate analysis, DFS was significantly associated with HPV (detected vs. not detected) with a hazard ratio of 0.07 (95 % confidence interval 0.008-0.6, p = 0.009). In this study, patients in whom HPV was not detected had the worst prognosis. Six months after RT, HPV DNA was detected in 0 % of the patients. Patients in whom HPV DNA could not be detected before treatment need careful follow-up for recurrence and may be considered for additional, or alternative treatment. (orig.)

  16. Prognostic Value of Blood Serum Content of Soluble CD50 and CD54 Molecules in Patients with Uterine and Cervical Cancer

    Directory of Open Access Journals (Sweden)

    М.Е. Mamaeva

    2015-12-01

    Full Text Available The aim of the investigation was to reveal the correlation of blood serum content of soluble CD50 and CD54 molecules in patients suffering from uterine and cervical cancer with oncological pathology localization, histological structure of the tumor, degree of tumor differentiation, and the extent of tumor invasion in the surrounding tissues, and to evaluate its significance for the disease prognosis. Materials and Methods. 83 patients aged 31 to 79 years were under observation. The serum level of soluble CD50 and CD54 molecules was determined by enzyme immunoassay with mouse monoclonal antibodies. Blood from the cubital vein was taken to obtain serum samples. Results. The development of malignant pathology of uterine and cervix was found to be accompanied by alteration of the serum level of CD50 and CD54 molecules. This alteration depends on oncological pathology localization, histological structure of the tumor, degree of tumor differentiation, and the extent of tumor invasion in the surrounding tissues. The serum level of soluble CD50 and oligomeric fractions of CD54 molecules was proved to decrease in patients with a worse prognosis. The initial concentration of soluble CD50 and CD54 molecules in the preoperative period can be considered an additional test allowing prediction of the disease progression in patients with uterine tumors.

  17. Postradiation sarcomas of the pelvis after treatment for uterine cervical cancer: review of the CT and MR findings of five cases

    International Nuclear Information System (INIS)

    Objective. To characterize the radiologic features of postradiation sarcomas arising in the pelvic bones following treatment for uterine cervical carcinoma. Design and patients. Five patients who developed postradiation sarcomas in the pelvic bones following radiation therapy for carcinoma of the uterine cervix within the irradiated field were evaluated. Pelvic radiographs, computed tomography (CT) and magnetic resonance (MR) imaging were undertaken in all patients. Histologic confirmation of the tumor type was obtained. Results. Three patients whose tumors were characterized as an osteosarcoma, an angiosarcoma and a malignant fibrous histiocytoma (MFH) showed a large round or oval mass mainly in the sacroiliac joint which extended into the posterior gluteal soft tissues. In a fourth patient an osteosarcoma developed in the central ilium extending widely into the soft tissues both anteriorly and posteriorly, with calcified areas within the extraosseous mass. The fifth patient had a MFH which showed osteolytic destruction of the cortex of the acetabulum, and minimal soft tissue extension. There were no specific features or signal intensity changes on MR imaging to differentiate these cases from primary sarcomas. Conclusion. Postradiation sarcoma must be considered in patients with uterine carcinoma when a soft tissue mass is seen in the previously irradiated field, especially if the mass is posterior to the sacroiliac joint and the latent period is more than 5 years. (orig.)

  18. Postradiation sarcomas of the pelvis after treatment for uterine cervical cancer: review of the CT and MR findings of five cases

    Energy Technology Data Exchange (ETDEWEB)

    Nakanishi, Katsuyuki [Osaka Seamen' s Insurance Hospital (Japan). Dept. of Radiology; Yoshikawa, Hideki [Osaka Univ. Medical School (Japan). Dept. of Orthopaedic Surgery; Ueda, Takafumi; Araki, Nobuhito [Osaka Medical Center for Cancer and Cardiovascular Diseases (Japan). Dept. of Orthopaedic Surgery; Tanaka, Hisashi; Nakamura, Hironobu [Osaka Univ. Medical School (Japan). Dept. of Radiology; Aozasa, Katsuyuki [Osaka Medical School (Japan). Dept. of Pathology

    2001-03-01

    Objective. To characterize the radiologic features of postradiation sarcomas arising in the pelvic bones following treatment for uterine cervical carcinoma. Design and patients. Five patients who developed postradiation sarcomas in the pelvic bones following radiation therapy for carcinoma of the uterine cervix within the irradiated field were evaluated. Pelvic radiographs, computed tomography (CT) and magnetic resonance (MR) imaging were undertaken in all patients. Histologic confirmation of the tumor type was obtained. Results. Three patients whose tumors were characterized as an osteosarcoma, an angiosarcoma and a malignant fibrous histiocytoma (MFH) showed a large round or oval mass mainly in the sacroiliac joint which extended into the posterior gluteal soft tissues. In a fourth patient an osteosarcoma developed in the central ilium extending widely into the soft tissues both anteriorly and posteriorly, with calcified areas within the extraosseous mass. The fifth patient had a MFH which showed osteolytic destruction of the cortex of the acetabulum, and minimal soft tissue extension. There were no specific features or signal intensity changes on MR imaging to differentiate these cases from primary sarcomas. Conclusion. Postradiation sarcoma must be considered in patients with uterine carcinoma when a soft tissue mass is seen in the previously irradiated field, especially if the mass is posterior to the sacroiliac joint and the latent period is more than 5 years. (orig.)

  19. The role o thallium-201 whole body scan with pelvic SPECT in patients with uterine cervical treated by radiation therapy. A preliminary report

    International Nuclear Information System (INIS)

    Evaluation of tumor extent before treatment and its response to therapy is important. The aim of this report is to assess the usefulness with thallium-201 (Tl-201) imaging study including whole body scan and pelvic single photon emission computed tomography (SPECT) in patients with uterine cervical cancers treated by radiation therapy. Before irradiation, eleven patients received detailed physical examination and Tl-201 imaging studies. A 4-score grading system was set for evaluation. The interval between Tl-201 imaging follow-up and completion of radiotherapy is one to four months, and its findings were compared with those from CT scan and clinical evidence. Before radiation, left supraclavicular and paraaortic lymphadenopathy was identified in one patient from whole body scan. Accumulation of Tl-201 uptake is observed from pelvic SPECT in all patients. It seems that patients with more tumor bulk had more intense uptake, except for one case with history of suspected pelvic inflammatory disease (PID). After radiotherapy, complete or partial regression is observed. For 6 patients with complete regression (score=0), no evidence of recurrence is confirmed by follow-up examinations. For three patients with little residual uptake (score=1), one is suspected with residual density and she is under close follow-up, the other two patients seem due to uterine myoma or short latency. These three patients received another Tl-201 scan 6 months after irradiation completion and the score became zero. One patient with residual intense uptake (score=2) suffered from relapse in the pelvis and abdomen. This preliminary report indicates that Tl-201 whole body scan and pelvic SPECT has potential in the assessment of response to radiotherapy in patients with uterine cervical cancers. However, further studies including more cases and longer follow-up are needed. (author)

  20. Therapeutic comparison of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages I b2-II a cervical cancer

    International Nuclear Information System (INIS)

    Objective: To compare the short-term and long-term therapeutic response of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages I b2-II a cervical cancer. Methods: One hundred and fifty-one patients with stages I b2-II a cervical cancer were treated with preoperative intra-arterial chemotherapy before radical hysterectomy was carried out. Patients in study group (n = 113) received uterine artery chemoembolization (UACE), while patients control group(n = 38) received internal iliac anterior trunk arterial chemotherapy. Radical hysterectomy was carried out in all patients within 2-4 weeks after UACE or chemotherapy. The tumor size was measured before and after the procedure,and the survival rate at 2 and 5 years after treatment was calculated. Results: The mean maximum diameter of the tumors was (4.58 ± 0.37) cm before interventional therapy, and it was (2.11 ± 0.24) cm in two weeks after interventional therapy. The complete response rate of study group and control group was 31.9% and 21.1% respectively. The total effective rate of study group and control group was 94.7% (107/113) and 76.3% (29/38) respectively. The effective rate of study group two weeks after therapy was significantly higher than that of control group. No surgical margin infiltration was observed in both groups. Pathological findings in study group included vascular invasion around surgical margin (n = 3), parametrial invasion (n = 5) and pelvic lymph node metastasis (n = 6), while in control group vascular invasion around surgical margin, parametrial invasion and pelvic lymph node metastasis were found in one, two and one cases respectively. The two-year and five-year survival rate in study group were 80.9% (68/84) and 73.4% (47/64) respectively, while the two-year and five-year survival rate in control group were 81.3% (26/32) and 75.0% (18/24) respectively. No significant difference in survival rate existed between two groups. Conclusion: Uterine artery chemoembolization can markedly reduce the volume of cervical cancer,which is very helpful for surgical resection. The therapeutic effectiveness of UACE is superior to internal iliac anterior trunk arterial chemotherapy, therefore, UACE should be regarded as neo-adjuvant intra-arterial chemotherapy of first choice for patients with stages I b2-II a cervical cancer. (authors)

  1. Dose to the non-involved uterine corpus with MRI guided brachytherapy in locally advanced cervical cancer

    DEFF Research Database (Denmark)

    Sapru, Shantanu; Mohamed, Sandy; Fokdal, Lars; Nkiwane, Karen; Swamidas, Jamema; Mahantshetty, Umesh; Kirisits, Christian; Pötter, Richard; Christian Lindegaard, Jacob; Tanderup, Kari

    2013-01-01

    BACKGROUND AND PURPOSE: This study evaluates the impact of MRI guided adaptive brachytherapy (BT) on uterine corpus dose. MATERIAL AND METHODS: 84 patients with median follow-up of 18 months were analysed. MRI based BT was done according to GEC-ESTRO guidelines. Non-involved uterine corpus at the time of BT was contoured and the uterine corpus dose (D90 and D98) was evaluated for (1) standard loading pattern with source loading to the tip of the tandem and (2) optimised dose plan. Tandem lengths...

  2. EVALUATION OF P16INK4A PROTEIN AS A BIOMARKER FOR CERVICAL INTRAEPITHELIAL NEOPLASIA AND SQUAMOUS CELL CARCINOMA OF THE UTERINE CERVIX

    Directory of Open Access Journals (Sweden)

    Biljana ?or?evi?

    2011-06-01

    Full Text Available The association of human papilloma virus (HPV infection and cervical intraepithelial neoplasia (CIN is well known. Interaction of HPV proteins with cellular regulatory proteins leads to up regulation of p16INK4A. The aim of this study was to evaluate p16INK4A protein as a biomarker for CIN lesions and squamous cell carcinoma on biopsy specimens of patients who underwent biopsy of the uterine cervix due to abnormal cytological finding.The authors analyzed biopsies from 50 patients with CIN and invasive squamous cell carcinoma of the uterine cervix. Expression of p16INK4A in CIN and invasive squamous cell carcinoma was immunohistochemically analyzed by using monoclonal anti-p16INK4A antibody.A total of 50 patients with CIN and invasive squamous cell carcinoma of the uterine cervix (mean age 40.2±11.5 years, range 20-74 years were analyzed. CIN I lesions were found in 27 (54%, CIN II/CIN III lesions in 9 (18%, and invasive squamous cell carcinoma in 14 (28% patients. Differences in the expression of p16INK4A between CIN I, CIN II/CIN III and squamous cell carcinoma were statistically significant (p<0.0001. Expression of p16INK4A showed low sensitivity (7%, specificity (8%, positive predictive value (8%, and negative predictive value (7% for CIN I. Sensitivity, specificity, positive predictive value, and negative predictive value of p16INK4A were 78%, 61%, 30%, and 93% for CIN II/CIN III, and 100%, 75%, 61%, and 100% for squamous cell carcinoma, respectively.Results of this study suggest that p16INK4A protein may be a sensitive biomarker for CIN II/CIN III lesions and invasive squamous cell carcinoma of the uterine cervix.

  3. A consensus-based guideline defining the clinical target volume for pelvic lymph nodes in external beam radiotherapy for uterine cervical cancer

    International Nuclear Information System (INIS)

    The objective of this study was to develop a consensus-based guideline as well as an atlas defining pelvic nodal clinical target volumes in external beam radiotherapy for uterine cervical cancer. A working subgroup to establish the consensus-based guideline on clinical target volumes for uterine cervical cancer was formulated by the Radiation Therapy Study Group of the Japan Clinical Oncology Group in July 2008. The working subgroup consisted of seven radiation oncologists. The process resulting in the consensus included a comparison of contouring on CT images among the members, reviewing of published textbooks and the relevant literature and a distribution analysis of metastatic nodes on computed tomography/magnetic resonance imaging of actual patients. The working subgroup defined the pelvic nodal clinical target volumes for cervical cancer and developed an associated atlas. As a basic criterion, the lymph node clinical target volume was defined as the area encompassed by a 7 mm margin around the applicable pelvic vessels. Modifications were made in each nodal area to cover adjacent adipose tissues at risk of microscopic nodal metastases. Although the bones and muscles were excluded, the bowel was not routinely excluded in the definition. Each of the following pelvic node regions was defined: common iliac, external iliac, internal iliac, obturator and presacral. Anatomical structures bordering each lymph node region were defined for six directions; anterior, posterior, lateral, medial, cranial and caudal. Drafts of the definition and the atlas were reviewed by members of the JCOG Gynecologic Cancer Study Group (GCSG). We developed a consensus-based guideline defining the pelvic node clinical target volumes that included an atlas. The guideline will be continuously updated to reflect the ongoing changes in the field. (author)

  4. Uterine Cervical Cancer Metastases to Mediastinal Lymph Nodes Diagnosed by Endoscopic Ultrasound-Guided Fine Needle Aspiration

    OpenAIRE

    Krishna, Somashekar G.; Ghouri, Yezaz A; Suzuki, Rei; Manoop S. Bhutani

    2013-01-01

    Utility of endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) for diagnosis of metastatic mediastinal lymph node (MLN) following an unproductive computed tomography (CT) guided-biopsy in a patient with cervical cancer. A 35-year-old woman with locally invasive cervical cancer was found to have a suspicious paraesophageal posterior MLN during the preliminary staging. Mediastinal metastasis from cervical cancer has been rarely reported. Mediastinal CT-guided-biopsy was non-diagnost...

  5. HPV type 18 is more oncopotent than HPV16 in uterine cervical carcinogenesis although HPV16 is the prevalent type in Chennai, India

    Directory of Open Access Journals (Sweden)

    V M Berlin Grace

    2009-01-01

    Full Text Available Context: The highest incidence of uterine cervical cancer in India is reported in Chennai. The prevalence and oncopotency are to be considered for the development of vaccines and therapeutic agents. Aims: The aim of the present study is to analyze the prevalence and oncopotency of high risk type HPV16 and 18 in cervical lesions. Settings and Design: This study is designed with 130 study subjects for analysis of selected types of HPV 6/11 and 16/18, in four groups, in a course of three years. The Bethesda system of classification is followed for grouping the samples, using histopathologic examination in biopsies. Materials and Methods: The biopsy samples were collected in 10% buffered formalin and were embedded in paraffin within 24 hours, for long-term preservation. The presence of HPV types were tested by PCR using type-specific primers for HPV16 and HPV18 in the DNA isolated from the subject?s biopsies. The stages of cervical lesions were identified by histopathology using the Hematoxylin Eosin stain. Statistical Analysis Used: The data were subjected to statistical analysis, using the SPSS and INSTAT software packages for their associations and risk estimation, respectively. The Graph Pad Prism 2 x 2 contingency table was used for risk estimation and the Kruskel Wallis test was used for analysis of the associations. Results: In the study population, the data indicated a high prevalence of HPV 16. However, during the course of study (1999 - 2003, four (66.6% dysplasia cases with HPV 18, three (21.4% dysplasia cases with HPV 16, and none with low-risk HPV6/11, turned into invasive cancer, within one year. Conclusions: The observation of the study implied that HPV16 had a high prevalence in uterine cervical cancer compared with HPV18 cases. However, the development of invasive cancer from precancerous lesions was more for HPV18 infected cases than for HPV16 during the study period, which indicated the higher oncopotency of HPV type 18.

  6. Japanese patterns of care study of postoperative radiotherapy for uterine cervical cancer. The assessment of treatment process of the 1995-2005 surveys

    International Nuclear Information System (INIS)

    The purpose of the study is to evaluate Japanese national practice patterns for patients undergoing postoperative radiotherapy for uterine cervical cancer. The Japan Patterns of Care Study (JPCS) collected the data of patients who were treated postoperative radiation therapy between 1995-1997 (JPCS 95-97), 1999-2001 (JPCS 99-01) and 2003-2005 (JPCS 03-05). Over 80% of patients were treated with external beam RT (ERT). ERT dose ranged from 45 to 50.4 Gy for over 70% of patients. The utilization rates of CT-simulation, multi-leaf collimator and over 10 MV photon energy were increased among three JPCS surveys. Positive lymph nodes, capillary lymphatic space tumor involvement and deep stromal invasion was the main reasons of adaptation of the postoperative radiotherapy. Compared with the previous 2 PCS studies, the patient who received concurrent chemoradiation was increased in JPCS 03-05 (6, 9% to 25%). (author)

  7. Dose to the non-involved uterine corpus with MRI guided brachytherapy in locally advanced cervical cancer

    DEFF Research Database (Denmark)

    Sapru, Shantanu; Mohamed, Sandy

    2013-01-01

    BACKGROUND AND PURPOSE: This study evaluates the impact of MRI guided adaptive brachytherapy (BT) on uterine corpus dose. MATERIAL AND METHODS: 84 patients with median follow-up of 18 months were analysed. MRI based BT was done according to GEC-ESTRO guidelines. Non-involved uterine corpus at the time of BT was contoured and the uterine corpus dose (D90 and D98) was evaluated for (1) standard loading pattern with source loading to the tip of the tandem and (2) optimised dose plan. Tandem lengths and heights of the 85 Gy isodose were recorded. RESULTS: Dose optimisation resulted in a reduction of active tandem length of 0.4±0.4 cm leading to lowering the D90 to the non-involved uterine corpus from 63.8±9.5 Gy to 56.7±7.5 Gy EQD2 (p<0.0001). Mean active tandem length was 5.0±1.0 cm, and the height of the 85 Gy isodose was 5.7±1.0 cm in optimised plans. CONCLUSIONS: MRI guided dose optimisation lowered the dose to the uterine corpus. However, a total EBRT+BT dose larger than 50 Gy was obtained in 99% of patients. Assuming that 45-50 Gy is sufficient to eradicate microscopic disease, the lowering of uterus corpus dose is not expected to induce additional uterine corpus recurrences in the setting of MRI guided adaptive BT. This hypothesis should be tested in a larger number of patients as e.g. the EMBRACE study.

  8. Características clínico patológicas del cáncer de cérvix uterino recurrente después de cirugía radical primaria. / Clinical and pathological features of recurrent uterine cervical cancer after primary radical surgery

    Scientific Electronic Library Online (English)

    Pedro, Aguilar; Henry, Valdivia.

    2012-03-01

    Full Text Available Objetivo: Describir las características clínico patológicas del cáncer de cérvix uterino recurrente, sitio y tiempo de recurrencia, y sobrevida después de la recurrencia de acuerdo a las variables de pronóstico en pacientes con cirugía radical primaria. Material y métodos: Estudio descriptivo, obser [...] vacional y retrospectivo, tipo serie de casos, realizado en el Instituto Nacional de Enfermedades Neoplásicas de Lima Perú entre 1990 y 2005. Se incluyeron todas las pacientes con cáncer de cérvix uterino estadios IB1 y IIA a quienes se les realizó cirugía radical primaria y que tuvieron recurrencia. Las curvas de sobrevida fueron construidas con el método de Kaplan-Meier. Resultados: Se realizaron 609 histerectomías radicales tipo III, 53(8,7%) tuvieron recurrencia. La edad promedio al diagnóstico de la recurrencia fue 44,5 años, el tiempo medio desde la cirugía hasta la recurrencia 18,9 meses y el sitio de recurrencia más frecuente fue a distancia (41,5%) seguido por recurrencia central y pélvica. El sitio de recurrencia y los márgenes quirúrgicos tuvieron significancia estadística con respecto al tiempo de recurrencia. La terapia de salvataje más frecuente fue la radioterapia (45%). La sobrevida promedio después de la recurrencia fue 26,9 meses y la tasa de sobrevida a 5 años 9,4%. Conclusiones: El cáncer cervical recurrente es poco frecuente, afecta a mujeres jóvenes y el sitio de recurrencia más frecuente es metástasis a distancia. El tiempo de recurrencia es más corto cuando la recurrencia es central y los márgenes quirúrgicos están afectados. La sobrevida después de la recurrencia en cáncer cervical tratado con cirugía radical es baja. Abstract in english Objective: To describe clinical and pathological features of recurrent uterine cervical cancer, including site and time to recurrence and survival after primary radical surgery. Methods: Descriptive, observational case series study conducted at the Instituto Nacional de Enfermedades Neoplásicas in L [...] ima between 1990 and 2005. Patients with recurrent uterine cervical cancer stages IB1 and IIA who had been treated with primary surgical resection were included. Kaplan-Meir survival curves were constructed. Results: 609 radical hysterectomies type II were performed; 53 (8.7%) had a recurrence. Mean age at diagnosis of recurrence was 44.5 years; mean time from surgery to recurrence was 18.9 months, and the most common site for recurrence was distant recurrence (415%), followed by central recurrence and pelvic recurrence. Site of recurrence and surgical margins had statistical association with time to recurrence. The most frequent salvage therapy was radiotherapy (45%). Mean survival time after recurrence was 26.9 months, and survival rate at 5 years was 9.4%. Conclusions: Recurrent uterine cervical cancer is not frequent, its affects young females causing distant metastasis mainly. Time to recurrence is shorter when recurrence is central and surgical margins are involved. Survival time after recurrence in patients treated surgically is short.

  9. Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino / Human papillomavirus genotyping of cervical uterine preneoplastic lesions in a high risk area

    Scientific Electronic Library Online (English)

    JAIME, LÓPEZ M; CARMEN GLORIA, ILI G; PRISCILLA, BREBI M; PATRICIA, GARCÍA M; ITALO, CAPURRO V; PABLO, GUZMÁN G; EUGENIO, SUÁREZ P; JOSÉ MANUEL, OJEDA F; JUAN CARLOS, ROA S.

    2010-11-01

    Full Text Available [...] Abstract in english The relationship between human papillomavirus (HPV) and uterine cervical cancer (UCC) is widely known and accepted. Aim: To determine the frequency of genotypes of HPV in cervical preneoplastic lesions in a high risk area of UCC. Material and Methods: Using a combination of PCR and Reverse Line Blot [...] technique, 235 formalin fixed paraffin embedded samples, with diagnosis of low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL) were genotyped. Results: HPV was detected in 61.2% of LSIL and 78.1% of HSIL. The main genotypes found were HPV 16, 18, 31, 45, 56 y 58. HPV 16 was the most common in both LSIL (18.1%) and HSIL (36.9%). HPV 16 or 18 were present in 25.1% and 47.1% of the LSIL and HSIL respectively. In both LSIL and HSIL, the predominant viral genotypes were those types classified as with a high oncogenic risk. Conclusions: HPV genotypes 16, 18, 31, 45, 56 y 58 were the most common in our series. HPV 16 and 18, viral types with high oncogenic risk and included in commercial vaccines, were found in 25.1% and 47.1% of LSIL and HSIL, respectively.

  10. Uterine fibroids

    Science.gov (United States)

    ... et al. Randomised comparison of uterine artery embolisation (UAE) with surgical treatment in patients with symptomatic uterine ... et+al.+Randomised+comparison+of+uterine+artery+embolisation+(UAE)+with+surgical+treatment+in+patients+with+symptomatic+uterine+ ...

  11. Screening for uterine tumours.

    Science.gov (United States)

    Van den Bosch, Thierry; Coosemans, An; Morina, Memli; Timmerman, Dirk; Amant, Frederic

    2012-04-01

    The most prevalent uterine tumours are leiomyomas, which are benign and have a prevalence of about 50% at menopause. The incidence of endometrial cancer and uterine sarcomas is about 25 per 100,000 and 0.7 per 100,000, respectively. Reported risk factors for endometrial cancer are advanced age, unopposed oestrogen stimulation, late menopause, obesity, diabetes mellitus, nulliparity, feminising ovarian tumours, polycystic ovarian syndrome, tamoxifen and belonging to a hereditary non-polyposis colorectal cancer family. Unopposed oestrogen stimulation and tamoxifen have also been confirmed to induce uterine sarcomas. Cervical cytology, endometrial sampling and ultrasound have been proposed in the early diagnosis of endometrial cancer. No pathognomonic ultrasound, magnetic resonance imaging or computed tomography features are able to differentiate between a leiomyoma and a uterine sarcoma, and reliable serum markers for sarcomas are lacking. To date, mass screening for uterine malignancies is not feasible or effective. PMID:22078749

  12. Cervical Cancer Rates by Race and Ethnicity

    Science.gov (United States)

    ... Associated Lung Ovarian Prostate Skin Uterine Cancer Home Cervical Cancer Rates by Race and Ethnicity Language: English Español ( ... Tweet Share Compartir The rate of women getting cervical cancer or dying from cervical cancer varies by race ...

  13. Conocimientos sobre prevención del cáncer cérvico-uterino en los adolescentes / Knowledge on the prevention of the cervical-uterine cancer in the adolescents

    Scientific Electronic Library Online (English)

    Regla Mercedes, García Rosique; Adelaida, Torres Triana; Marlén, Rendón Quintero.

    2011-04-01

    Full Text Available En Cuba, al igual que en el resto de los países occidentales, el cáncer cérvico-uterino se encuentra en segundo lugar de morbilidad oncológica en mujeres de 20 a 30 años; y a ctualmente está considerado como una infección de transmisión sexual. Hay estudios que revelan información deficiente por par [...] te de los adolescentes en cuanto a las infecciones de transmisión sexual y sus consecuencias. Es por ello, que en el período comprendido entre febrero y noviembre de 2009 se realizó una investigación descriptiva con el objetivo de identificar los conocimientos sobre prevención del cáncer cérvico-uterino en los adolescentes de la ESBU Manuel Sanguily, del municipio Matanzas. El universo estuvo integrado por los alumnos de noveno grado, y para la selección de la muestra se utilizó un muestreo probabilístico por conglomerados monoetápico. Se aplicó un cuestionario, cuyos resultados relevantes indicaron que los varones iniciaron sus primeras relaciones sexuales a los 13 años y las hembras a las edades de 13 y 14 años, representado un 57,1 % y 50 %, respectivamente. Solo el 12,7 % de los adolescentes identificó al virus del papiloma humano como factor de riesgo en la génesis del cáncer cérvico-uterino. El bajo nivel de conocimientos para la prevención de este tipo de cáncer predominó en el 92,7 % de la muestra. Se concluye que en el grupo de adolescentes estudiados, lo más frecuente fue el inicio temprano de las relaciones sexuales, tanto para varones como para hembras, aunque estas últimas representaron solo el 10 %. Se identificó desconocimiento sobre el virus del papiloma humano como agente causal de esta morbilidad, y pobre conocimiento sobre cómo prevenirlo. Abstract in english In Cuba, as in the rest of the Western countries, the cervical-uterine cancer is in the second place of oncologic morbidity in 20-to-30 years-old women; currently it is considered a sexually transmitted infection. There are some studies revealing deficient information on the part of the teenagers as [...] for the sexually transmitted diseases and theirs consequences. That is why, in the period from February to November 2009 we carried out a descriptive investigation with the objective of identifying the knowledge on the prevention of the cervical-uterine cancer the students of the Secondary School Manuel Sanguily, Municipality of Matanzas, have. The universe was formed by the nine grade students, and to select the sample we used a probabilistic sampling by mono-stage conglomerates. A questionnaire was applied and the results indicated that the males began their first sexual relationships to the 13 years and the females to the ages of 13 and 14 years, representing 57,1 % and 50 %, respectively. Only 12,7 % of the teenagers identified the human papilloma virus as a risk factor in the genesis of the cervical-uterine cancer. The low level of knowledge for the prevention of this kind of cancer prevailed in 92,7 % of the sample. We concluded that in the group of teenagers we studied, the most frequent fact was that they began early having sexual relationships, both boys and girls, although the last ones represented only 10 %. We identified ignorance on the human papilloma virus and poor knowledge about how to prevent it as the casual agent of this morbidity.

  14. Conocimientos sobre prevención del cáncer cérvico-uterino en los adolescentes Knowledge on the prevention of the cervical-uterine cancer in the adolescents

    Directory of Open Access Journals (Sweden)

    Regla Mercedes García Rosique

    2011-04-01

    Full Text Available En Cuba, al igual que en el resto de los países occidentales, el cáncer cérvico-uterino se encuentra en segundo lugar de morbilidad oncológica en mujeres de 20 a 30 años; y a ctualmente está considerado como una infección de transmisión sexual. Hay estudios que revelan información deficiente por parte de los adolescentes en cuanto a las infecciones de transmisión sexual y sus consecuencias. Es por ello, que en el período comprendido entre febrero y noviembre de 2009 se realizó una investigación descriptiva con el objetivo de identificar los conocimientos sobre prevención del cáncer cérvico-uterino en los adolescentes de la ESBU Manuel Sanguily, del municipio Matanzas. El universo estuvo integrado por los alumnos de noveno grado, y para la selección de la muestra se utilizó un muestreo probabilístico por conglomerados monoetápico. Se aplicó un cuestionario, cuyos resultados relevantes indicaron que los varones iniciaron sus primeras relaciones sexuales a los 13 años y las hembras a las edades de 13 y 14 años, representado un 57,1 % y 50 %, respectivamente. Solo el 12,7 % de los adolescentes identificó al virus del papiloma humano como factor de riesgo en la génesis del cáncer cérvico-uterino. El bajo nivel de conocimientos para la prevención de este tipo de cáncer predominó en el 92,7 % de la muestra. Se concluye que en el grupo de adolescentes estudiados, lo más frecuente fue el inicio temprano de las relaciones sexuales, tanto para varones como para hembras, aunque estas últimas representaron solo el 10 %. Se identificó desconocimiento sobre el virus del papiloma humano como agente causal de esta morbilidad, y pobre conocimiento sobre cómo prevenirlo.In Cuba, as in the rest of the Western countries, the cervical-uterine cancer is in the second place of oncologic morbidity in 20-to-30 years-old women; currently it is considered a sexually transmitted infection. There are some studies revealing deficient information on the part of the teenagers as for the sexually transmitted diseases and theirs consequences. That is why, in the period from February to November 2009 we carried out a descriptive investigation with the objective of identifying the knowledge on the prevention of the cervical-uterine cancer the students of the Secondary School Manuel Sanguily, Municipality of Matanzas, have. The universe was formed by the nine grade students, and to select the sample we used a probabilistic sampling by mono-stage conglomerates. A questionnaire was applied and the results indicated that the males began their first sexual relationships to the 13 years and the females to the ages of 13 and 14 years, representing 57,1 % and 50 %, respectively. Only 12,7 % of the teenagers identified the human papilloma virus as a risk factor in the genesis of the cervical-uterine cancer. The low level of knowledge for the prevention of this kind of cancer prevailed in 92,7 % of the sample. We concluded that in the group of teenagers we studied, the most frequent fact was that they began early having sexual relationships, both boys and girls, although the last ones represented only 10 %. We identified ignorance on the human papilloma virus and poor knowledge about how to prevent it as the casual agent of this morbidity.

  15. Adenocarcinoma involving the uterine cervix: magnetic resonance imaging findings in tumours of endometrial, compared with cervical, origin

    Energy Technology Data Exchange (ETDEWEB)

    Haider, M.A. [Univ. of Toronto, Dept. of Medical Imaging, Univ. Health Network, Mount Sinai Hospital, Toronto, Ontario (Canada)]. E-mail: mhaider@utoronto.ca; Patlas, M. [McMaster Univ., Dept. of Radiology, Hamilton General Hospital, Hamilton, Ontario (Canada); Jhaveri, K. [Univ. of Toronto, Dept. of Medical Imaging, Univ. Health Network, Mount Sinai Hospital, Toronto, Ontario (Canada); Chapman, W. [Univ. of Toronto, Dept. of Pathology, Univ. of Health Network, Toronto, Ontario (Canada); Fyles, A. [Univ. of Toronto, Dept. of Radiation Oncology, Princess Margaret Hospital, Univ. Health Network, Toronto, Ontario (Canada); Rosen, B. [Univ. of Toronto, Dept. of Obstetrics and Gynecology, Univ. Health Network, Toronto, Ontario (Canada)

    2006-02-15

    To determine the distinctive magnetic resonance imaging (MRI) features of cervical and endometrial adenocarcinoma that present clinically as cervical mass. From 1999 to 2002, 56 patients with adenocarcinoma on the initial biopsy of a cervical mass underwent MRI at our institution. Of these, 42 had a visible mass on MRI. Pathology review of all available tissue was the reference standard. A site of origin was determined by the pathologist in 38 of the 42 patients, and these were the cases evaluated; of these patients, 32 cases had adenocarcinoma and 6 had adenosquamous cancers. Findings were significantly more prevalent in patients with adenocarcinomas of endometrial, compared with cervical, origin for endometrial thickening (11 [73%] and 3 [13%], respectively; P = 0.0003), endometrial mass (11 [73%] and 1 [4%], respectively; P < 0.0001), endometrial cavity expansion by a mass (9 [60%] and 2 [9%], respectively; P = 0.001), and invasion of myometrium from endometrium (9 [60%] and 0, respectively; P < 0.0001). Adenocarcinomas of the endometrium that involve the cervix have MRI features that help distinguish them from primary adenocarcinomas of the cervix. (author)

  16. Value of FDG-PET vs MRI/CT in detection and staging of early uterine cervical cancer

    International Nuclear Information System (INIS)

    This prospective study was performed to define the efficiency of FDG-PET in detecting primaries and in preoperatively assessing lymph node metastases of cervical cancer. Forty one patients with cervical cancer were investigated with PET (370 MBq F-18-FDG, Siemens ECAT EXACT HR+, visual evaluation) and MRI prior radical hysterectomy with pelvic, and additionally 12 cases paraortal, lymphadenectomies. Histopathological evaluation verified in all cases the evidence of cervical cancer except in one case, where the tumor was completely removed by conisation procedure. Sensitivity of PET and MRI were 95% and 85%, respectively. In 16/82 pelvic lymph node sites metastases were histologically detected (7 x micrometastases). Sensitivity, specificity, positive positive and negative predictive value were 50%, 85%, 44% and 88% for PET and 31%, 90%, 40% and 86% for MRI. Out of the 12 cases with dissection of paraortal lymph nodes, metastases were found histologically in 3 cases. PET detected 2/3 truly with no false positive result while CT detected 0/3 cases with no false positive findings. It is concluded that PET can detect cervical cancer with high accuracy. The accuracy of PET and MRI was similar for detection of pelvic metastases. Both methods have limited sensitivity due to the high incidence of micrometastases. PET was more accurate than CT in detection of paraortal metastases

  17. La promoción de salud dirigida a reducir los factores de riesgo de cáncer cérvico uterino / Health promotion aimed to reducing uterine cervical cancer risk factors

    Scientific Electronic Library Online (English)

    Misleny, Martínez Pérez; Juan Carlos, de la Concepción Cárdenas; Ariel, Pérez González.

    2014-06-01

    Full Text Available La primera Conferencia Internacional sobre la Promoción de la Salud celebrada en Ottawa, el 21 de noviembre de 1986, definió la promoción de la salud como “el proceso de permitir a la gente aumentar su control sobre su salud y por lo tanto mejorarla”. Se reconoce claramente que la promoción de la sa [...] lud va más allá de los estilos de vida, en la cual la educación para la salud constituye, junto a la comunicación y a la participación social, herramientas necesarias para su instrumentación en el primer nivel de atención. En la práctica cotidiana se desconoce de forma reiterada el valor que tiene el reconocimiento adecuado de las dimensiones de la promoción de salud, desde una perspectiva holística, dirigidas a reducir los factores de riesgo de cáncer cérvico uterino. El propósito del estudio fue realizar una contribución teórica a la promoción de salud para contribuir al fortalecimiento del Programa Nacional de Diagnóstico Precoz del Cáncer Cérvico Uterino. Al considerar el valor de esta disciplina desde sus dimensiones, el profesional de la salud dispone de una base teórica que guíe las acciones dirigidas a la reducción de factores de riesgos de este tipo de cáncer en la población femenina. Abstract in english The first International Conference on Health Promotion celebrated in Ottawa on November 21st, 1986, defined health promotion as “the process allowing people to increase the control on their health and therefore to improve it”. It is clearly understood that health promotion goes beyond life styles, a [...] nd also includes education for health, communication and social participation, necessary tools for its instrumentation in the first health care level. In every day practice it is continually not recognized the value of the adequate acknowledgement of health promotion dimensions, from a holistic perspective, aimed to reducing the uterine cervical cancer risk factors. The purpose of the research was theoretically contributing to the strengthening of the National Program of Uterine Cervical Cancer Precocious Diagnosis. When considering the value of this discipline in all its dimensions, the health care professional has a theoretical base to guide the actions aimed to reducing the risk factors of this kind of cancer among the female population.

  18. Quality assurance in the prospective multi-institutional trial on definitive radiotherapy using high-dose-rate intracavitary brachytherapy for uterine cervical cancer. The individual case review

    International Nuclear Information System (INIS)

    The objective of this study was to assess compliance with the radiotherapy protocol of a multi-institutional prospective study (JAROG0401/JROSG04-2), which investigated the efficacy and toxicity of definitive radiotherapy using high-dose-rate intracavitary brachytherapy (HDR-ICBT) for early-stage uterine cervical cancer patients. Individual case reviews (ICRs) were performed on all 60 study participants. Radiotherapy data were submitted to the quality assurance (QA) committee, which performed ICRs on 16 QA items according to previously selected criteria. The items focused on quality of external beam radiotherapy (EBRT), HDR-ICBT and both. Each item was determined to be either acceptable or a deviation. The QA committee performed ICR three times as planned, two during the patient accrual and the final one just after the final patient accrued. The QA results of the first and second reviews were reported back to the investigators after each ICR. In 40 cases (67%), all 16 QA items were classified as acceptable. One deviation was found in 16 cases, two deviations were identified in 3 cases and three deviations were noted in 1 case. The most frequently observed deviation was missing the rules for determining point A (10 cases). The items described by quantitative values, such as prescribed doses, certain time intervals and overall treatment time, were well followed. The proportion of deviations gradually decreased during the ICR process. The present ICR demonstrated the favorable radiotherapy compliance with the JAROG0401/JROSG04-2 protocol. The QA process using ICRs can potentially be used to improve the quality of radiotherapy, including HDR-ICBT in the multi-institutional prospective studies for cervical cancer. (author)

  19. Relation of cervical glandular intraepithelial neoplasia to microinvasive and invasive adenocarcinoma of the uterine cervix: a study of 121 cases.

    OpenAIRE

    KURIAN, K; Al-Nafussi, A

    1999-01-01

    AIMS: To examine the relation between invasive adenocarcinoma and its alleged precursor, cervical glandular intraepithelial neoplasia (CGIN), and to assess the management and outcome of CGIN and the validity of using the term "microinvasive adenocarcinoma." METHODS: The clinical and pathological features of 121 cases of glandular neoplasia of the cervix diagnosed between the years 1990 to 1995 were examined for the following: histological diagnosis, smear records, type of treatment, the assoc...

  20. Protein p 16INK4A expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of uterine cervix

    Directory of Open Access Journals (Sweden)

    Gupta Ruchi

    2010-01-01

    Full Text Available The association of human papilloma virus (HPV infection and cervical intraepithelial neoplasia (CIN is well recognized. Interaction of HPV oncogenic proteins with cellular regulatory proteins leads to up regulation of p16 INK4A , a CDK inhibitor, which is a biomarker for HPV infection. We investigated p16 expression in CIN and invasive squamous cell carcinoma (SCC which has not been reported in the Indian population previously. Materials and Methods: Retrospective analysis of 100 cases with 20 cases each of histologically normal cervical epithelium, CIN1, 2, 3 and invasive SCC for p16 expression was performed by immunohistochemistry using commercially available mouse monoclonal antibody to p16 (clone 6H12. Statistical Analysis: For differences in expression among groups, statistical analysis was carried out using ANOVA and post hoc test of Scheffe. Results: p16 immunoreactivity was found to be both nuclear and/or cytoplasmic. The normal cervical epithelium was predominantly negative for p16 (18/20. There was a progressive increase of p16 expression with the grade of CIN. In CIN 1, two cases (20% showed nuclear and nucleocytoplasmic positivity respectively. In contrast, diffuse strong nuclear or nucleocytoplasmic expression was observed in 45 and 55% cases of CIN 2 and CIN 3 respectively. All except one squamous cell carcinoma stained strongly positive for p16. The difference in expression between CIN 2/3 and SCC versus normal cervix was found highly significant (p is equal to 0.008 and p less than 0.001. Conclusions: p16 expression correlates excellently with the grade of CIN and is a sensitive marker of cervical intraepithelial neoplasia.

  1. Diferencias sociales de la detección oportuna de cáncer cérvico uterino en las mujeres trabajadoras de una universidad de la ciudad de México / Social differences in proper detection of cervical uterine cancer among employees at a university in Mexico City

    Scientific Electronic Library Online (English)

    Ulises, Trejo Amador; José Arturo, Granados Cosme; Luis, Ortiz Hernández; Guadalupe, Delgado Sánchez.

    2005-06-01

    Full Text Available Fundamento: En México el cáncer cérvicouterino (CACU) es una de las principales causas de muerte en mujeres; sin embargo, se ha encontrado una baja participación en los programas de su detección oportuna (DOCACU). El objetivo de este estudio fue describir los determinantes sociales del conocimiento [...] sobre el cáncer cérvicouterino y la realización de la detección oportuna estableciendo las diferencias sociales que al respecto muestra una población de mujeres trabajadoras de una universidad pública de México. Métodos: Se realizó un estudio transversal analítico. Entre marzo y abril de 2003 se aplicó una encuesta a una muestra representativa de las trabajadoras que laboraban en una universidad pública (n=228), 110 eran académicas (AC) y 118 administrativas (AD). Se eligió esta población por su elevada diferenciación socioeconómica en función del puesto laboral (AC vs. AD), esto permitió evaluar la influencia de la desigualdad social sobre las conductas en salud. La encuesta exploró tres aspectos: condiciones de vida, conocimiento del CACU y DOCACU. Resultados: Las mujeres académicas mostraron mayores niveles de ingreso, escolaridad, conocimiento del CACU y DOCACU que las administrativas. El ingreso y la escolaridad se relacionaron positivamente con el conocimiento sobre el cáncer cervicouterino, la realización de detección oportuna se relacionó con este último. Conclusiones: La desigualdad socioeconómica entre las mujeres estudiadas se reflejó en diferencias en el grado de conocimiento y en la práctica de la detección oportuna. Estas diferencias se asocian, sobre todo, a las diferencias en el grado de escolaridad. Abstract in english Background: In Mexico, cervical uterine cancer (CUC) is one of the leading causes of death among women, however a low degree of participation in the early detection programs has been found. This study is aimed at describing the social determinants of knowledge related to cervical uterine cancer and [...] proper testing being conducted by establishing the social differences with regard thereto among a population of female employees at a public university in Mexico. Methods: An analytical cross-sectional study was made. During the March-April 2003 period, a survey was conducted of a representative sample of the female employees who were working at a public university (n=228), 110 of whom were professors (PF) and 118 administrative staff (AS). This population was chosen due to the major socioeconomic differentiation thereof in terms of their job positions (PF versus AS), thus affording the possibility of evaluating the bearing social inequality has on health-related behavior. The survey explored three aspects: living conditions, knowledge of CUC and of proper cervical uterine cancer detection testing. Results: The female professors showed higher levels of income, schooling and knowledge of CUC and of cervical uterine cancer detection testing than the administrative staff. Income and schooling were positively related to the knowledge regarding cervical uterine cancer, cervical uterine cancer detection testing being related to the latter. Conclusions: Socioeconomic inequality among the women studied was reflected in differences in the degree of knowledge and in cervical uterine cancer detection testing being undergone. These differences are associated, above all, to the differences in the level of schooling.

  2. Diferencias sociales de la detección oportuna de cáncer cérvico uterino en las mujeres trabajadoras de una universidad de la ciudad de México / Social Differences in Proper Detection of Cervical Uterine Cancer among Employees at a University in Mexico City

    Scientific Electronic Library Online (English)

    Ulises, Trejo Amador; José Arturo, Granados Cosme; Luis, Ortiz Hernández; Guadalupe, Delgado Sánchez.

    2005-06-01

    Full Text Available Fundamento: En México el cáncer cérvicouterino (CACU) es una de las principales causas de muerte en mujeres; sin embargo, se ha encontrado una baja participación en los programas de su detección oportuna (DOCACU). El objetivo de este estudio fue describir los determinantes sociales del conocimiento [...] sobre el cáncer cérvicouterino y la realización de la detección oportuna estableciendo las diferencias sociales que al respecto muestra una población de mujeres trabajadoras de una universidad pública de México. Métodos: Se realizó un estudio transversal analítico. Entre marzo y abril de 2003 se aplicó una encuesta a una muestra representativa de las trabajadoras que laboraban en una universidad pública (n=228), 110 eran académicas (AC) y 118 administrativas (AD). Se eligió esta población por su elevada diferenciación socioeconómica en función del puesto laboral (AC vs. AD), esto permitió evaluar la influencia de la desigualdad social sobre las conductas en salud. La encuesta exploró tres aspectos: condiciones de vida, conocimiento del CACU y DOCACU. Resultados: Las mujeres académicas mostraron mayores niveles de ingreso, escolaridad, conocimiento del CACU y DOCACU que las administrativas. El ingreso y la escolaridad se relacionaron positivamente con el conocimiento sobre el cáncer cervicouterino, la realización de detección oportuna se relacionó con este último. Conclusiones: La desigualdad socioeconómica entre las mujeres estudiadas se reflejó en diferencias en el grado de conocimiento y en la práctica de la detección oportuna. Estas diferencias se asocian, sobre todo, a las diferencias en el grado de escolaridad. Abstract in english Background: In Mexico, cervical uterine cancer (CUC) is one of the leading causes of death among women, however a low degree of participation in the early detection programs has been found. This study is aimed at describing the social determinants of knowledge related to cervical uterine cancer and [...] proper testing being conducted by establishing the social differences with regard thereto among a population of female employees at a public university in Mexico. Methods: An analytical cross-sectional study was made. During the March-April 2003 period, a survey was conducted of a representative sample of the female employees who were working at a public university (n=228), 110 of whom were professors (PF) and 118 administrative staff (AS). This population was chosen due to the major socioeconomic differentiation thereof in terms of their job positions (PF versus AS), thus affording the possibility of evaluating the bearing social inequality has on health-related behavior. The survey explored three aspects: living conditions, knowledge of CUC and of proper cervical uterine cancer detection testing. Results: The female professors showed higher levels of income, schooling and knowledge of CUC and of cervical uterine cancer detection testing than the administrative staff. Income and schooling were positively related to the knowledge regarding cervical uterine cancer, cervical uterine cancer detection testing being related to the latter. Conclusions: Socioeconomic inequality among the women studied was reflected in differences in the degree of knowledge and in cervical uterine cancer detection testing being undergone. These differences are associated, above all, to the differences in the level of schooling.

  3. A case report of anal cancer preceded by perianal Paget's disease after irradiation for uterine cervical cancer and review of perianal Paget's disease in Japan

    International Nuclear Information System (INIS)

    The patient was a 59-year-old woman. Total hysterectomy and irradiation were performed for uterine cervical cancer 25 year previously. Paget's cells resembling signet ring cells were found in the epidermis, and anal cancer was present adjacent to them. The histological diagnosis of the anal cancer was mainly well differentiated adenocarcinoma, but mucinous carcinoma was present containing signet ring cells at sites contiguous with the anal glands, and lymphatic permeation was noted in the dermis. The cancer and the Paget's cells were both positive for PAS and alcian blue staining and were negative for PB/KOH/PAS staining. Furthermore, such findings as atypia of the glandular ducts and endoarteritis were detected in the underlying mucosa. Therefore, it was considered that this patient had anal cancer derived from the anal glands, that the Paget's cells were due to the intraepidermal extension of signet ring cells, and that the cancer may have been related to her previous irradiation. Reports of cancer of the rectum and anus complicated by Paget's lesion in Japan were reviewed and studied with regard to the histogenesis. It was concluded that peri-anal Paget's lesion had a close relationship with anal cancer derived from the anal glands. (author)

  4. Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy; Aberracoes cromossomicas instaveis em linfocitos de pacientes com cancer de colo de utero

    Energy Technology Data Exchange (ETDEWEB)

    Magnata, Simey de Souza Leao Pereira

    2002-09-01

    Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of {sup 69} Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

  5. Cerebral metastasis of cervical uterine cancer: report of three cases Metástases cerebrais de câncer de colo de útero: relato de três casos

    Directory of Open Access Journals (Sweden)

    Joacir Graciolli Cordeiro

    2006-06-01

    Full Text Available Cervical uterine cancer (CUC spreads locally (pelvis and paraortic lymphnodes or distantly (lungs, liver and bones. Metastasis to central nervous system (CNS are rare. There are about 80 cases reported in the literature. Outcome is poor and survival varies from 3 to 6 months. Three cases of CNS metastasis from CUC are reported, one infratentorial and two supratentorials in location. In one patient, the initial manifestation was due to the cerebral lesion, a feature reported for the first time. All cases were treated by surgery, radiotherapy and/or chemotherapy. Clinical findings and treatment options of these rare lesions are reviewed.Tumores do cólo uterino se disseminam por contigüidade ou via hematogênica (pulmão, fígado e ossos. Metástases para sistema nervoso central são incomuns. Apenas cerca de 80 casos são citados na literatura. Manifestações clínicas são devidas à hipertensão intracraniana e a déficits focais. A sobrevida varia de 3 a 6 meses. Três casos são relatados sendo um infratentorial e dois supratentoriais. No primeiro, o diagnóstico da metástase antecedeu o da lesão uterina. No segundo, houve 5 anos sem recidiva após a cirurgia, fato este inédito. O tratamento foi cirurgia, radioterapia e/ou quimioterapia. A discussão enfatiza manejo multidisciplinar destas raras lesões.

  6. Tendência da mortalidade por câncer do útero no Município de São Paulo entre 1980 e 1999 / Mortality trends from uterine cervical cancer in the city of São Paulo from 1980 to 1999

    Scientific Electronic Library Online (English)

    Luiz Augusto Marcondes, Fonseca; Adriana de Souza, Ramacciotti; José, Eluf Neto.

    2004-02-01

    Full Text Available O câncer do colo do útero apresenta grande incidência em algumas cidades brasileiras e considerável mortalidade em países em desenvolvimento, não obstante a disponibilidade já antiga de teste de rastreamento. O presente estudo visou avaliar a tendência da mortalidade por câncer de colo do útero, de [...] corpo do útero e por câncer do útero não especificado, no Município de São Paulo, entre 1980 e 1999, por meio do exame das taxas brutas, idade-específica e ajustadas por idade. Os resultados mostraram discreta redução da mortalidade por câncer do colo do útero, queda da mortalidade por câncer de útero não especificado e aumento da mortalidade por câncer do corpo do útero. Conclui-se que a queda da mortalidade por câncer do útero não especificado sinaliza uma melhora na precisão do diagnóstico clínico e na qualidade do preenchimento do atestado de óbito, e indica aumento de cobertura do teste de Papanicolaou. Abstract in english Uterine cervical cancer shows a higher incidence in some Brazilian cities. It is a common cause of death in women from developing countries, despite the longstanding availability of an effective screening test, the Pap smear. This study aimed to evaluate the temporal trends of crude, age-adjusted, a [...] nd age-specific mortality rates from cervical cancer, endometrial cancer, and cancer of the uterus not otherwise specified (NOS) in the city of São Paulo from 1980 to 1999. Results showed a slight reduction in cervical cancer rates, a decrease in NOS uterine cancer rates, and an increase in endometrial cancer mortality rates. The fall in mortality from NOS uterine cancer indicates an improvement in diagnostic accuracy and quality of information on death certificates and may point to an increase in coverage of cervical cancer screening using the Pap smear.

  7. Srinagarind Hospital experience in concurrent chemoradiation for 100 patients with stage IB2 to IVA uterine cervical cancer

    International Nuclear Information System (INIS)

    The aim of this study was to determine responses, acute adverse effects, and survival outcomes of women with stage IB2 to IVA treated with weekly cisplatin concurrent with pelvic irradiation at Srinagarind Hospital. The medical records of 100 women with cervical cancer stage IB2 to IVA who were treated with weekly cisplatin 40 mg/m2 concurrent with pelvic radiotherapy at Srinagarind Hospital between January 2003 and June 2006 were reviewed and analyzed. During the study period, 100 women were eligible for analysis, with a mean age of 46 years (range 24-60 years). Distribution according to International Federation of Gynecology and Obstetrics (FIGO) staging was IB2 1.0%, IIB 47.0%, IIIB 51.0%, and IVA 1.0%, respectively. A total of 86 patients received five or more cycles of weekly cisplatin. Grade 3 and 4 hematologic toxicities were found in 6.0%. The overall response rate was 97.0%. Complete response was achieved in 86 patients (86.0%) and partial response in 11 patients (11.0%). Stable disease was found in 1 patient (1.0%) but no progressive disease was found. Progression-free survival and overall survival rate were 69.6% and 96.1%, respectively. Weekly cisplatin (40 mg/m2) concurrent with pelvic irradiation for locally advanced cervical cancer was effective with acceptable toxicity in Thai women. (author)

  8. Sensory and motor dysfunction assessed by anorectal manometry in uterine cervical carcinoma patients with radiation-induced late rectal complication

    International Nuclear Information System (INIS)

    Purpose: To investigate the effects of radiation on anorectal function in patients with carcinoma of the uterine cervix. Methods and Materials: Anorectal manometry was carried out on 24 patients (complication group) with late radiation proctitis. All of the manometric data from these patients were compared with those from 24 age-matched female volunteers (control group), in whom radiation treatment had not yet been performed. Results: Regardless of the severity of proctitis symptoms, 25% of patients demonstrated all their manometric data within the normal range, but 75% of patients exhibited one or more abnormal manometric parameters for sensory or motor functions. Six patients (25%) had an isolated sensory dysfunction, eight patients (33.3%) had an isolated motor dysfunction, and four patients (16.7%) had combined disturbances of both sensory and motor functions. The maximum tolerable volume, the minimal threshold volume, and the urgent volume in the complication group were significantly reduced compared with those in the control group. The mean squeeze pressure in the complication group was significantly reduced, whereas the mean resting pressure and anal sphincter length were unchanged. Conclusions: Physiologic changes of the anorectum in patients with late radiation proctitis seem to be caused by a variety of sensory and/or motor dysfunctions in which many different mechanisms are working together. The reduced rectal reservoir capacity and impaired sensory functions were crucial factors for functional disorder in such patients. In addition, radiation damage to the external anal sphincter muscle was considered to be an important cause of motor dysfunction

  9. Ganglio centinela para estadios tempranos en cáncer de cuello uterino / Sentinel lymph node detection in early uterine cervical cancer

    Scientific Electronic Library Online (English)

    Henry, Valdivia; Rossana, Morales; Luis, Taxa; Manuel, Álvarez; Carlos, Santos; Albert, Zevallos; Carlos, Velarde; Marco, Sánchez; Aldo, López; Absalón, Montoya.

    Full Text Available Objetivo: Determinar la factibilidad y seguridad del ganglio centinela (GC) con el uso combinado del mapeo linfático con Tc 99 y la inyección de colorante azul (patent blue) en pacientes con cáncer de cérvix temprano sometidas a histerectomía radical con linfadenectomía pélvica bilateral. Diseño: Es [...] tudio prospectivo. Institución: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú. Participantes: Pacientes con cáncer temprano de cuello uterino. Intervenciones: Entre diciembre de 2003 y diciembre de 2006, 66 pacientes con cáncer temprano de cuello estadios IA2 (n=2), IB1 (n=63) y IIA (n=1) fueron sometidas a detección del ganglio linfático centinela con linfoscintigrafía el día previo a la operación y mapeo linfático intraoperatorio con colorante azul y sonda detectora de radiación gama. El tratamiento quirúrgico se completó con la realización de la histerectomía radical y linfadenectomía pélvica bilateral, por laparotomía. Principales medidas de resultados: Detección de ganglios centinelas. Resultados: En las 66 pacientes estudiadas se detectó 136 ganglios centinelas, con un promedio de 2,06 por paciente. Se utilizó el método combinado (Tc 99 y patent blue). La localización más frecuente fue la región obturatriz con un 69,9% (n=95). Se halló metástasis en los ganglios pélvicos en 11 pacientes, que fueron correctamente localizadas en el ganglio centinela con una sensibilidad de 100%. Cuando el ganglio centinela fue negativo, no se encontró metástasis en los ganglios no centinela (VPN 100%). Conclusiones: La identificación del ganglio centinela con tecnecio-99 combinado con la inyección de colorante azul es factible y mostró un valor predictivo negativo de 100%. Abstract in english Objective: To determine sentinel node (SN) detection feasibility and safety by using lymphatic mapping with 99m Tc Dextrán and injection of blue dye (patent blue) in patients with early cervical cancer undergoing radical hysterectomy with bilateral pelvic lymphadenectomy. Design: Prospective study. [...] Setting: Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru. Participants: Patients with early cervical cancer. Interventions: Between December 2003 and December 2006, 66 patients with early cervical cancer stages IA2 (n = 2), IB1 (n = 63) and IIA (n = 1) underwent sentinel lymph node detection with lymphoscintigraphy the day before operation and intraoperative lymphatic mapping with blue dye and gamma radiation detection probe. Surgical treatment was completed with radical hysterectomy and bilateral pelvic lymphadenectomy by laparotomy. Main outcome measures: Sentinel node detection. Results: One hundred and thirty-six sentinel nodes were detected in all 66 patients, average 2.06 per patient, by using the combined method 99m Tc dextrán and patent blue. Most common location was the obturator region in 69.9% of cases (n = 95). Pelvic lymph node metastases were found by the sentinel node in 11 patients (sensitivity of 100%). In negative sentinel node cases (55 patients) no metastases were encountered (negative predictive value, NPV = 100%). Conclusions: Sentinel node identification using 99m technetium Dextrán and blue dye injection is feasible and had a negative predictive value of 100%.

  10. Radiotherapy quality assurance of the Japanese gynecologic oncology group study (JGOG1066). A cooperative phase II study of concurrent chemoradiotherapy for uterine cervical cancer

    International Nuclear Information System (INIS)

    The background of this study was to assess radiotherapy protocol compliance in a multi-institutional phase II study of concurrent chemoradiotherapy for patients with locally advanced cancer of the uterine cervix (JGOG1066). For study protocol development, various radiotherapy parameters were examined and consensus was reached by Japanese radiation oncologists with cervical cancer treatment expertise. Quality assurance (QA) was also discussed and included in the protocol. A credentialing process was used to select institutions for participation in the study. Individual case reviews referring to 18 QA items were undertaken for each patient. Radiotherapy data were submitted to the Japanese Gynecologic Oncology Group (JGOG) data center and reviewed by the members of the radiotherapy committee. The QA evaluation was classed as per protocol, deviation, and violation. Individual case reviews were performed on 69 of 72 patients entered in the study. In 24 patients (35%), there were no deviations for any QA items. There were also no deviations seen for 5 of the 18 items in 69 patients evaluated. Deviations of 64 QA items were seen in 45 cases, and violations were seen in 4 cases (4 items). The most common deviation concerned appropriate application for the external beam radiotherapy (EBRT) boost to involved nodes or parametrium (32 cases). The 4 violations were identified in the QA items regarding high-dose rate intracavitary brachytherapy. Radiotherapy protocol compliance was favorable except for the EBRT boost indications. The results of this study validate the quality of radiotherapy in JGOG1066, and indicate that the final analysis will provide meaningful results. (author)

  11. Changes in tumor oxygen tension during radiotherapy of uterine cervical cancer: relationships to changes in vascular density, cell density, and frequency of mitosis and apoptosis

    International Nuclear Information System (INIS)

    Purpose: Changes in oxygen tension (pO2) during the early phase of fractionated radiotherapy were studied in 22 patients with uterine cervical cancer. The aims were to investigate (a) whether possible changes in pO2 differed among and within tumors and (b) whether the changes could be attributed to changes in vascular density, cell density, and frequency of mitosis and apoptosis. Methods and Materials: The pO2 was measured polarographically in four regions of the tumors before treatment and after 2 weeks of radiotherapy. The vascular density, cell density, and frequency of mitosis and apoptosis were determined from biopsies taken from the tumor regions after each pO2 measurement. Results: The changes in pO2 during therapy differed among the tumors and were correlated to pO2 before treatment (p 2 and vice versa. The tumors with increased pO2 (n = 10) had a large decrease in cell density and a significant increase in apoptotic frequency. In contrast, the tumors with decreased pO2 (n = 10) had a smaller decrease in cell density (p = 0.014) and no significant increase in apoptotic frequency. Vascular density and mitotic frequency showed no change during therapy; however, vascular damage other than decreased vascular density was observed. Conclusion: These results indicate that the oxygenation of cervix tumors generally changes during the early phase of radiotherapy. The change depends on the balance between the factor leading to an increase and that leading to a decrease in oxygenation; i.e., decreased cell density and vascular damage, respectively. Increased apoptotic frequency may contribute to a large decrease in cell density and hence increased oxygenation during therapy

  12. Critérios de positividade para cervicografia digital: melhorando a sensibilidade do diagnóstico do câncer cervical / Digital cervicography criteria: improving sensitivity in uterine cervical cancer diagnosis

    Scientific Electronic Library Online (English)

    Eugênio Santana, Franco; Silvia Bomfim, Hyppólito; Rosana Gomes de Freitas Menezes, Franco; Mônica Oliveira Batista, Oriá; Paulo César de, Almeida; Lorita Marlena Freitag, Pagliuca; Nelson Fernando Pacheco da, Rocha.

    2008-11-01

    Full Text Available O objetivo deste trabalho foi validar critérios de positividade para cervicografia digital. Estudo realizado com 300 mulheres submetidas a protocolo clínico composto por exame citológico, uma avaliação por meio de cervicografia digital sem ampliação de imagem (Avaliação 1), e outra avaliação também [...] usando cervicografia digital mas com ampliação adicional de imagem e os critérios de positividade propostos neste estudo (Avaliação 2). A idade média das mulheres foi de 27,6 anos. Os critérios de positividade para cervicografia digital foram identificados em 111 casos (100%) dos testes positivos para lesões precursoras do câncer do colo uterino e em 8 casos (2,6%) considerados falso-positivos. As avaliações 1 e 2 classificaram os exames como positivos (163; 54,3%) e suspeitos (146; 48,6%), respectivamente. Os resultados revelam que a cervicografia digital foi mais sensível (99,1%) e a citologia mais específica (100%). O desempenho alcançado pela cervicografia digital, quando aplicado os critérios de positividade, alcançou sensibilidade 4,5 vezes superior ao desempenho da citologia oncológica, além do baixo custo, sugerindo ser uma técnica factível. Abstract in english This study aimed to validate the scoring criteria for digital cervicography. The study enrolled 300 women submitted to a clinical protocol using cytological examination alone, digital cervicography without image magnification (Evaluation 1), and digital cervicography plus additional image magnificat [...] ion and considering the positive criteria (Evaluation 2). Women's mean age was 27.6 years. Positive criteria for digital cervicography were identified in 111 positive cases with pre-cancerous cervical lesions (100%) and in 8 cases classified as false positives (2.6%). Evaluations 1 and 2 classified the tests as positive (163; 54.3%) and suspected (146; 48.6%), respectively. According to the findings, digital cervicography was more sensitive (99.1%) and cytology more specific (100%). Digital cervicography sensitivity increased by 4.5 times when the positive criteria were applied as compared to cytology alone, besides involving low cost, thus suggesting that it is a viable technique.

  13. Critérios de positividade para cervicografia digital: melhorando a sensibilidade do diagnóstico do câncer cervical Digital cervicography criteria: improving sensitivity in uterine cervical cancer diagnosis

    Directory of Open Access Journals (Sweden)

    Eugênio Santana Franco

    2008-11-01

    Full Text Available O objetivo deste trabalho foi validar critérios de positividade para cervicografia digital. Estudo realizado com 300 mulheres submetidas a protocolo clínico composto por exame citológico, uma avaliação por meio de cervicografia digital sem ampliação de imagem (Avaliação 1, e outra avaliação também usando cervicografia digital mas com ampliação adicional de imagem e os critérios de positividade propostos neste estudo (Avaliação 2. A idade média das mulheres foi de 27,6 anos. Os critérios de positividade para cervicografia digital foram identificados em 111 casos (100% dos testes positivos para lesões precursoras do câncer do colo uterino e em 8 casos (2,6% considerados falso-positivos. As avaliações 1 e 2 classificaram os exames como positivos (163; 54,3% e suspeitos (146; 48,6%, respectivamente. Os resultados revelam que a cervicografia digital foi mais sensível (99,1% e a citologia mais específica (100%. O desempenho alcançado pela cervicografia digital, quando aplicado os critérios de positividade, alcançou sensibilidade 4,5 vezes superior ao desempenho da citologia oncológica, além do baixo custo, sugerindo ser uma técnica factível.This study aimed to validate the scoring criteria for digital cervicography. The study enrolled 300 women submitted to a clinical protocol using cytological examination alone, digital cervicography without image magnification (Evaluation 1, and digital cervicography plus additional image magnification and considering the positive criteria (Evaluation 2. Women's mean age was 27.6 years. Positive criteria for digital cervicography were identified in 111 positive cases with pre-cancerous cervical lesions (100% and in 8 cases classified as false positives (2.6%. Evaluations 1 and 2 classified the tests as positive (163; 54.3% and suspected (146; 48.6%, respectively. According to the findings, digital cervicography was more sensitive (99.1% and cytology more specific (100%. Digital cervicography sensitivity increased by 4.5 times when the positive criteria were applied as compared to cytology alone, besides involving low cost, thus suggesting that it is a viable technique.

  14. Arteriovenous malformation in uterine cervix during pregnancy

    OpenAIRE

    Kim, Sung-Mee; Jang, Won Kyu; Park, Joon-Cheol; Rhee, Jeong-Ho; Kim, Jong-In; Bae, Jin-Gon

    2014-01-01

    As the development of Doppler ultrasonography, many cases of uterine arteriovenous malformation (AVM) have beed diagnosed. But there is no case of cervical AVM in pregnant uterus. We present a 33-year-old pregnant woman who was diagnosed with AVM of the uterine cervix during the midtrimester. Color Doppler sonography and magnetic resonance image were used for diagnosis. We performed Cesarean section because of the risk of massive bleeding from the cervical AVM at 34 weeks' gestation. This is ...

  15. Uterine prolapse

    Science.gov (United States)

    Pelvic relaxation - uterine prolapse; Pelvic floor hernia; Prolapsed uterus ... Tightening the pelvic floor muscles using Kegel exercises helps to strengthen the muscles and reduces the risk of uterine prolapse. Estrogen therapy ...

  16. Radioterapia: percepção de mulheres com câncer cérvico-uterino / Radiotherapy: perception of women with uterine-cervical cancer / Radioterapia: percepción de mujeres con cáncer cérvico-uterino

    Scientific Electronic Library Online (English)

    Lúcia Helena Rios Barbosa de, Almeida; Yarla Brena Araújo de Sousa, Pereira; Thais Alexandre de, Oliveira.

    2008-08-01

    Full Text Available Realizou-se um estudo qualitaitvo com objetivo de conhecer a percepção das mulheres com câncer cérvico-uterino sobre a radioterapia, descrevendo as alterações físicas e cotidianas sofridas e evidenciando meios de enfrentamento e expectativas em relação ao tratamento. Foram entrevistadas 20 mulheres [...] em um hospital especializado, localizado na cidade de Teresina-PI. Os resultados mostraram que elas percebem a radioterapia como um bom tratamento, apesar do medo diante do desconhecido e das limitações no cotidiano, devido aos efeitos colaterais, que são enfrentados com suporte na religiosidade e no âmbito sócio-familiar, aumentando a expectativa de cura. Revelou-se a importância da orientação a essas mulheres pela equipe multiprofissional, especialmente o Enfermeiro, em todas as fases do tratamento. Abstract in spanish Se realizó un estudio con abordaje cualitativo objetivando conocer la percepción de las mujeres con cáncer cérvico-uterino sobre la radioterapia, describiendo las alteraciones físicas y cotidianas sufridas y evidenciando el medio utilizado para que enfrenten esas adversidades y sus expectativas con [...] relación al tratamiento. Fueron entrevistadas 20 mujeres en un hospital especializado, localizado en la ciudad de Teresina-PI. Los resultados mostraron que ellas perciben la radioterapia como un buen tratamiento, a pesar del miedo delante de lo desconocido y de las limitaciones en el cotidiano, debido a los efectos colaterales, que son enfrentados con base en la religiosidad y en el ámbito socio-familiar, aumentando la expectativa de cura. Se reveló la importancia de la orientación a esas mujeres por el equipo multiprofesional, especialmente el Enfermero, en todas las fases del tratamiento. Abstract in english This is a qualitiative study that aimed to know the perception of women with uterine-cervical cancer on the radiotherapy, describing the physical and daily alterations they suffered and evidencing the their coping to face these adversities and their expectations about the treatment. 20 women in a sp [...] ecialized hospital had been interviewed, located in the city of Teresina-PI. The results showed that they perceive the radiotherapy as a good treatment, although the fear ahead of the stranger and the limitations in the daily one, had to the side-effects, that are faced with support in the religious and the social-familiar scope, increasing the cure expectation. The importance of the orientation to these women for the multiprofessional team showed, especially the Nurse, in all the phases of the treatment.

  17. Citologia oncológica, captura de híbridos II e inspeção visual no rastreamento de lesões cervicais / Pap smear, hybrid capture II, and visual inspection in screening for uterine cervical lesions

    Scientific Electronic Library Online (English)

    Renata Clementino, Gontijo; Sophie Françoise Mauricette, Derchain; Eliana Borin Lopes, Montemor; Luis Otávio Zanatta, Sarian; Márcia Milena Pivatto, Serra; Luiz Carlos, Zeferino; Kari Juhani, Syrjanen.

    2005-02-01

    Full Text Available Avaliar as alterações na citologia oncológica, na captura híbrida II e na inspeção visual com ácido acético (IVA) a 5% em 684 mulheres atendidas em uma unidade de saúde, e avaliar o desempenho e a concordância entre os exames. Procurar descrever as características sócio-demográficas e reprodutivas ( [...] SDR) destas mulheres e sua associação com a presença de doença. As mulheres foram submetidas à coleta de citologia, captura e IVA, e as com exame positivo foram submetidas à colposcopia com biopsia, se necessário. Foi calculado o desempenho dos testes e a associação dos fatores SDR com o diagnóstico histológico foi avaliada por intermédio do cálculo do odds ratio. Embora 198 mulheres apresentassem pelo menos um teste alterado, apenas 21 apresentaram lesão histológica. A sensibilidade dos testes foi semelhante enquanto as especificidades da IVA e da citologia foram maiores que a da captura híbrida II. Apenas a ausência de citologia esteve associada à presença de doença. O desempenho da citologia foi maior que o da IVA, que foi maior que o da captura. A ausência de citologia foi associada com doença histológica. Abstract in english The objective of this study was to evaluate alterations in Pap smear, hybrid capture II (HCII), and visual inspection with acetic acid (VIA) in 684 women treated at a primary health care unit. The performance and agreement of the exams were evaluated. The study also described social, demographic, an [...] d reproductive factors and their association with uterine cervical lesions. Women had specimens taken for Pap smear, HCII, and VIA. When at least one of the tests was positive, colposcopy was performed and targeted biopsies were taken from any suspicious lesions. Performance of tests was evaluated. Women's distribution in relation to social, demographic, and reproductive factors and histological diagnosis was evaluated using the odds ratio. Among 198 women with at least one positive screening test, only 21 showed histological disease. Sensitivities of the tests were similar. VIA and Pap smear presented higher specificity than HCII. Only absence of a previous Pap smear was associated with the presence of histological disease. Pap smear performed better than VIA and HC II. Absence of previous cytology was associated with histological disease.

  18. Lymphedema After Surgery in Patients With Endometrial Cancer, Cervical Cancer, or Vulvar Cancer

    Science.gov (United States)

    2014-12-23

    Lymphedema; Stage IA Cervical Cancer; Stage IA Uterine Corpus Cancer; Stage IA Vulvar Cancer; Stage IB Cervical Cancer; Stage IB Uterine Corpus Cancer; Stage IB Vulvar Cancer; Stage II Uterine Corpus Cancer; Stage II Vulvar Cancer; Stage IIA Cervical Cancer; Stage IIIA Vulvar Cancer; Stage IIIB Vulvar Cancer; Stage IIIC Vulvar Cancer; Stage IVB Vulvar Cancer

  19. Evaluación del seguimiento de mujeres con cáncer cervicouterino en dos policlínicos. Pinar del Río / Follow-up assessment of women suffering from cervical uterine cancer in two polyclinics, Pinar del Rio

    Scientific Electronic Library Online (English)

    José Guillermo, Sanabria Negrín; Inalvis de la Caridad, Cruz Hernández; Leonardo, Oriolo Pérez; Miguel Angel, Pérez Herrera; Beatriz, Valdés Abreu.

    2012-06-01

    Full Text Available Introducción: A pesar de contar con un programa de detección precoz del cáncer cervicouterino de larga duración aún no se logran los resultados esperados. Objetivo: Caracterizar a las pacientes con cáncer invasor del cuello uterino en dos áreas de salud de Pinar del Río en el quinquenio 2003-2007. M [...] aterial y Método: Estudio observacional, transversal, de cohorte, retrospectivo de mujeres de cualquier edad con diagnóstico de cáncer cervicouterino invasor. La información de las pacientes se tomó de los registros automatizados de las lesiones de cuello uterino de la consulta provincial de Patología de Cuello, del Provincial de Cáncer (Dirección Provincial de Salud), y del de Mortalidad General (Dirección Provincial de Salud) así como de las historias clínicas de la Unidad Oncológica Provincial. Entre las variables estudiadas estuvieron si procedían o no del programa, edad, estadio clínico, tratamiento recibido, incidencia anual y el promedio en la etapa, la mortalidad y la letalidad. Resultados: Se encontró que el 70,6% de casos no se detectó por programa. La tasa de incidencia promedio fue 29.5 por 100000 mujeres de 15 años y más. Todas las pacientes recibieron el tratamiento oncoespecífico según estadio clínico. Las mayores tasas de mortalidad se encontraron en las pacientes en estadio IIIB al diagnóstico. Conclusiones: Se detectan fallas en la Atención Primaria de Salud, por falta de detección. Las tasas de incidencia de esta enfermedad no se han logrado disminuir. Y se siguen diagnosticando casos en estadios avanzados de la enfermedad, lo que acorta la sobrevida de estas pacientes. Abstract in english Introduction: Despite of having a program, for a long time, to the early detection of cervical uterine cancer, the results expected are not as far achieved. Objective: to characterize the patients suffering from invasive cervical uterine cancer in two health areas in Pinar del Rio province throughou [...] t five years (2003-2007). Material and Methods: observational, cross-sectional, cohort, retrospective study including women at every age with invasive cervical-uterine cancer. The information concerning the patients was collected from the automated records of cervical uterine at the provincial office for cervix pathology treatment (Provincial Public Health Direction), general death rate (Provincial Public Health Direction) and from the clinical histories of the Provincial Cancer Unit. Among the variables studied were: coming or not from the program, age, clinical stage, treatment followed, and annual incidence, together with the average of mortality and lethality considering the clinical stages. Results: 70,6% of the cases were not detected by the program. The average incidence rate was 29.5 per 10 0000 women from 15 years old or older. All patients underwent to a specific cancer treatment according to the clinical stage. The greatest mortality rates were found in patients presenting IIIB stage at diagnosis. Conclusion: errors were observed in Primary Health Care leading to deficiencies in the early detection of this type cancer. The incidence rates of this disease have not diminished; cases suffering from advanced stages of the disease are still detected, shortening the survival rate of these patients.

  20. Uterine Cancer

    Science.gov (United States)

    ... is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, the lining of the uterus. This type of cancer is sometimes called endometrial cancer. The symptoms of ...

  1. Uterine Cancer

    Science.gov (United States)

    ... time in your life before starting menopause. • Taking Tamoxifen, a drug used to treat certain types of breast cancer. • Having people in your family with a history of uterine, colon, or ovarian cancer. If one or more ...

  2. Uterine sarcoma

    Science.gov (United States)

    ... cause is unknown, there's no way to prevent uterine sarcoma. If you have had radiation therapy in your pelvic area or have taken tamoxifen for breast cancer, ask your provider how often you should be ...

  3. Uterine transplantation.

    Science.gov (United States)

    Brännström, Mats; Racho El-Akouri, Randa; Wranning, Caiza Almén

    2003-08-15

    Uterine factor infertility is either due to congenital malformation or acquired. Most women with uterine factor infertility have no chance to become genetic mothers, except by the use of gestational surrogacy. The logical but radical approach for treatment would be replacement of the unfunctional or absent uterus. Uterine transplantation could allow these women to become both genetic and gestational mothers. The present work reviews the existing literature on the history and recent development around this topic. We also briefly describe a newly developed model for heterotopic uterine transplantation in the mouse, in which pregnancies have been accomplished. Some specific issues that are required to be solved prior any further attempts to transplant the uterus in humans are also addressed. PMID:12860325

  4. MRI appearances of benign uterine disease

    International Nuclear Information System (INIS)

    Benign uterine disease is a common entity affecting women of all ages. Ultrasound has historically been the predominant imaging method used in the evaluation of benign gynaecological disease, magnetic resonance imaging (MRI) being reserved for use in the staging of malignant uterine and cervical disease. MRI is now increasingly used in the diagnosis of benign uterine disease as well as a tool for problem-solving in cases of diagnostic dilemma. It allows detailed assessment of benign conditions, such as endometrial lesions, leiomyomas, and adenomyosis, and can be helpful in the stratification of patients to different treatment modalities, including surgical resection, uterine artery embolization, and medical therapies. In this article, we review the MRI findings in the common benign uterine diseases

  5. Avaliação do Comprimento do Colo Uterino nas Posições Ortostática e Decúbito Horizontal nas Gestações Gemelares Uterine Cervical Length Evaluation in the Standing and Recumbent Positions in Twin Pregnancies

    Directory of Open Access Journals (Sweden)

    Tatiana Bernáth

    2002-05-01

    Full Text Available Objetivo: avaliação ultra-sonográfica e comparação da medida do comprimento do colo uterino nas gestações gemelares com as pacientes nas posições de decúbito dorsal horizontal (DDH e ortostática. Métodos: 50 gestações gemelares foram submetidas a avaliações ultra-sonográficas para medida do comprimento do colo uterino no período de maio de 1999 a dezembro de 2000. Os exames foram realizados pela via transvaginal com periodicidade de 4 semanas totalizando 136 avaliações. A cérvice uterina foi avaliada, segundo técnica normatizada, com a paciente nas posições de decúbito dorsal horizontal e ortostática. Resultados: as medidas do colo uterino nas posições DDH e ortostática na primeira avaliação apresentaram correlação inversa com a idade gestacional (DDH: r=-0,60; pPurpose: to compare cervical length measurements in twin pregnancies obtained by transvaginal ultrasound examination in the recumbent and standing positions. Methods: fifty twin pregnancies underwent transvaginal ultrasound examinations to measure the cervical length with the women in recumbent and standing positions. The study was carried out between May 1999 and December 2000. The scans were repeated every 4 weeks and the total number of evaluations was 136. Two groups were analyzed: one included only the first ultrasound examinations carried out in each woman and the second group included all evaluations. Results: in the first group, cervical length measurements in the standing and recumbent positions correlated inversely with the gestational age (recumbent: r=-0.60; p<0.001; standing: r=-0.46; p=0.008. The mean measure in the recumbent position was 35.2 mm (SD=9.9 mm and 33.4 mm (SD=9.5 mm in the standing position. When the difference between the measure obtained in the standing and recumbent positions was expressed as percentage of the measure in the recumbent position, there was no significant association with gestational age (p=0.07. When all evaluations were considered, there was a significant association between cervical length in the recumbent and standing positions (r=0.79; p<0.001. The measures in recumbent and standing positions were inversely correlated with gestational age (recumbent: p<0.0001; standing: p<0.0001. The mean cervical length in the recumbent position was 33.5 mm (SD=10.8 mm and 31.8 mm (SD=9.6 mm in the standing position. There was no significant association between cervical length difference expressed as percentage of the measure in the recumbent position and gestation. Conclusion: cervical length measure obtained with the patients in the recumbent and standing positions provided similar information.

  6. MRI findings of small cell neuroendocrime carcinoma of the uterine cervix: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Won, You Sun; Yi, Boem Ha; Lee, Hae Kyung; Lee, Min Hee; Choi, Seo Youn; Kwak, Jeong Ja [Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon (Korea, Republic of)

    2015-10-15

    Small cell neuroendocrine carcinoma of the uterine cervix is a rare primary neoplasm, accounting for less than 5% of all uterine cervical cancers. The tumor is known to have an aggressive behavior and poor prognosis. In this article, we present the MRI findings of 5 cases of pathologically-proven small cell neuroendocrine carcinoma of the uterine cervix, including diffusion-weighted images.

  7. MRI findings of small cell neuroendocrime carcinoma of the uterine cervix: A case report

    International Nuclear Information System (INIS)

    Small cell neuroendocrine carcinoma of the uterine cervix is a rare primary neoplasm, accounting for less than 5% of all uterine cervical cancers. The tumor is known to have an aggressive behavior and poor prognosis. In this article, we present the MRI findings of 5 cases of pathologically-proven small cell neuroendocrine carcinoma of the uterine cervix, including diffusion-weighted images

  8. Magnetic resonance imaging of cancer of uterine cervix and body. Preliminary study in 9 cases of body cancer and 20 of cervical cancer

    International Nuclear Information System (INIS)

    We studied nine cases of endometrial carcinoma and twenty of cervix carcinoma. Correlation with histology is made after curietherapy in 8 cases of endometrial carcinoma. Tumor is not always seen and particularly when there is no mass effect on macroscopic examination. Myometral invasion is not seen with accuracy: the interruption of junctional zone is not a good sign. The cervix tumors are well seen on T2 sequences before any treatment. There extra uterine extension is difficult to appreciate. The best results of RMI were in the follow-up after radiotherapy. Therefore it appears actually to us the best indication of RMI

  9. The benefit of small bowel and pelvic bone sparing in excluding common iliac lymph node region from conventional radiation fields in patients with uterine cervical cancer. A dosimetric study

    International Nuclear Information System (INIS)

    The purpose of this study was to compare dose reduction to the small bowel and sacral bone by two-field and four-field techniques when the common iliac lymph node region is excluded from the radiation field in external beam radiotherapy of uterine cervical cancer. Thirteen patients with cervical cancer were entered into the study. Conventional treatment plans based on bony landmarks were made with parallel-opposed two-field technique (C2F) and four-field box technique (C4F). Modified C2F (M2F) and C4F (M4F) plans of excluding the common iliac lymph node region from the conventional radiation fields were created in reference to the bifurcations of pelvic arteries in computed tomography images. For each patient, the dose volume histograms for the small bowel and sacral bone resulting from the C2F, C4F, M2F, and M4F plans were compared. The volumes were obtained at 10 levels of prescribed dose, at increments of 10%, from 5 Gy to 50 Gy. By sparing both small bowel and sacral bone, the M2F and M4F plans were significantly better than the C2F and C4F plans at any dose level (p<0.05), respectively. In addition, the M4F plan was significantly better than the M2F plan in sparing both small bowel at 10-50% of the prescribed dose (p<0.05) and sacral bone at 40-100% of the prescribed dose (p<0.05). The present study suggests that modified treatment planning could be useful for selected patients for reducing small bowel complications and insufficiency fracture after radiotherapy. (author)

  10. Uterine Lesions

    Directory of Open Access Journals (Sweden)

    A. Kurjak

    2005-08-01

    Full Text Available Transvaginal color and pulsed Doppler ultrasound depicts the endometrium in great details. The texture and thicknessof the endometrium are indicators of endometrial development, while blood flow analysis may be used as a bioassay of the uterine receptivity. This method can non-invasively detect uterine anomalies, endometrial polyps,submucous leiomyomas, intrauterine adhesions and other uterine causes that can lead to poor reproductive performance. Vascularization of the uterine tumors, if used together with analysis of morphology and size, can increase our accuracy in differentiation between uterine sarcoma and leiomyoma. It seems that the multiparameter sonographic approach, which includes morphology and size depicted by transvaginal ultrasonography and color flow imaging withpulsed Doppler analysis of neovascular signals,can help in diagnosis of uterine sarcoma in high-risk groups such as postmenopausal patients with a rapidly enlarging uterus. Therefore, serial measurements are recommended for evaluation of the myometrial density, follow-up of the tumoral growth, and detection of the impedance to blood flow.Only such complex observations can lead to proper diagnosis of these rare tumors with unpredictable prognosis. The application of transvaginal color Doppler to the postmenopausal population for screening of endometrial carcinoma may be a viable option if combined with ovarian screening in the same scan. In this way, the capital costs would be shared, and an oncological preventive medicine for women could be created. The use of this technique could also result in a reduction in dilatation and curettage operations with considerable saving of both the potential risks and economic costs of the operation.

  11. Lesões precursoras do câncer cervicouterino: evolução histórica e subsídios para consulta de enfermagem ginecológica Lesiones precursoras del cáncer cervical-útero: evolución histórica consolidando la consulta de enfermería ginecológica Cervical-uterine cancer precursor lesions: historical evolution supporting the gynecological nursing consultation

    Directory of Open Access Journals (Sweden)

    Maria Cristina de Melo Pessanha Carvalho

    2010-09-01

    Full Text Available Estudo emergido de recorte de dissertação de mestrado, ilustrando a evolução histórica das lesões precursoras do câncer cervicouterino (LPCCU. Trata-se da história das LPCCU, delineando a relevância do conhecimento para prática do enfermeiro na área da saúde da mulher. O conceito de LPCCU inicia-se a partir do século XIX, dando início aos estudos das células alteradas. Objetivo: descrever as diversas fases da evolução histórica das alterações cervicais. Estudo qualitativo, descritivo-analítico, recorte temporal no período de 1940 a 2008. Dados levantados mediante bibliografia de fonte primária e recurso BIREME. Pontuaram-se as classificações que já existiram, destacando a Nomenclatura Brasileira, importante para corresponder às necessidades e o perfil da saúde das mulheres do Brasil. Este estudo é o ponto de partida para respaldar as práticas de consulta de enfermagem ginecológica com abordagens educativas, contemplando a população feminina em ações preventivas e incentivo ao tratamento.Estudio emergido de recorte de disertación de máster, ilustrando la evolución histórica de las lesiones precursoras del cáncer cervical-uterino (LPCCU. Se trata de la historia de las LPCCU, delineando la relevancia del conocimiento para la práctica del enfermero en cuidados en la salud de la mujer. El concepto de LPCCU se inicia a partir del siglo XIX, empezando los estudios de las células alteradas. Como objetivo: describir las diversas fases históricas de las alteraciones cervicales. Estudio cualitativo, descriptivo-analítico, recorte temporal en el período de 1940 hasta 2008. Datos acrecentados mediante bibliografía de fuente primaria y recurso BIREME. Se puntuó las diferentes clasificaciones que ya existieron, conde destaque para la nomenclatura brasileña, importante para corresponder a las necesidades y el perfil de la salud de las mujeres del Brasil. Esto estudio es el ponto de partida para respaldar las prácticas de consulta de enfermería ginecológica con abordajes educativas, contemplando la población femenina en acciones preventivas y incentivo al tratamiento.Study emerged from an article of the master degree that illustrates the phases of the historical evolution of the precursor lesions of the cervical-uterine cancer. Thus, it is a question of the history about, delineating the relevance of this knowledge for the nurse's practice in care in the woman's health. The precursor lesions concept of the cervical-uterine cancer, initiates itself from the XIX century, beginning with studies of the cells altered. It had as objective: describe the diverse historical phases of the cervical-uterine cancer. A qualitative, descriptive-analytical study, using time cutting in the period of 1940 to 2008. The data were raised by means of bibliographical reference as primary spring and about the resource BIREME, By means of this study was possible to score the different classifications that already existed, highlighting the Brazilian Nomenclature was important to correspond the needs and the profile of the health of the women of Brazil. This study is the starting point to support the gynecological nursing consultation practices with educational approaches, contemplating the female population in preventive actions and incentive to the treatment.

  12. Laparoscopia quirúrgica en cáncer de cuello uterino, en el Hospital IV Huancayo EsSalud / Surgical laparoscopy in uterine cervical cancer at EsSalud Huancayo Hospital

    Scientific Electronic Library Online (English)

    Ernesto, Molina-Loza; Carlos, Altez-Navarro; Gregorio, Ortiz-Lorenzo.

    Full Text Available Introducción: El cáncer de cérvix es la causa más frecuente de muerte en la sierra central peruana. El tratamiento quirúrgico (histerectomía total laparoscópica e histerectomía radical más linfadenectomía pélvica laparoscópica) es el recurso terapéutico mayormente curativo en los estadios iníciales [...] (Ia1, Ia2 y Ib1). Hace un año en el Servicio de Ginecología del Hospital IV Huancayo iniciamos el tratamiento quirúrgico laparoscópico en estos estadios. Objetivos: Revisar los resultados de histerectomía laparoscópica en cáncer microinvasivo de cuello uterino. Diseño: Estudio retrospectivo. Institución: Servicio de Ginecología, Hospital IV Huancayo, EsSalud, Junín, Perú. Pacientes: Doce mujeres sometidas a histerectomía laparoscópica por carcinoma microinvasivo de cérvix. Intervenciones: En seis mujeres con diagnóstico preoperatorio de cáncer de cérvix por conización cervical y estadio clínico Ia1 se les realizó histerectomía laparoscópica, con un tiempo operatorio de 59,16 minutos y tiempo de estancia hospitalaria de 4,1 días. A otras seis mujeres con estadio clínico Ia2-Ib1 se les realizó histerectomía radical más linfadenectomía pélvica laparoscópica, con un tiempo operatorio de 3 horas 58 minutos y tiempo de estancia hospitalaria de 10,1 días. Principales medidas de resultados: Curación clínica. Resultados: Todos los diagnósticos fueron confirmados con la pieza operatoria, y todas las pacientes están teóricamente curadas (márgenes libres, ganglios negativos); una paciente presentó complicaciones, requiriendo estancia prolongada (8,3%). Conclusiones: La histerectomía total laparoscópica y la histerectomía radical más linfadenectomía pélvica laparoscópica pueden ser realizadas de manera más rápida y radical con respecto a la histerectomía convencional por laparotomía. Ambas son intervenciones factibles y seguras, que pueden garantizar la curación en el carcinoma microinvasivo de cuello uterino. Abstract in english Introduction: Cervical cancer is the most common cause of death in Peruvian central highlands. Surgical treatment (hysterectomy and total laparoscopic radical hysterectomy plus pelvic lymphadenectomy) is the best therapeutic resource in the early cancer stage (IA1, IA2 and IB1). One year ago we star [...] ted laparoscopic surgical treatment in these stages at Hospital IV Huancayo Gynecology Department. Objectives: To review outcomes of laparoscopic hysterectomy for microinvasive cervical cancer. Design: Retrospective study. Setting: Gynecology Service, Hospital IV Huancayo, EsSalud, Junin, Peru. Patients: Twelve women subjected to laparoscopic hysterectomy for cervical microinvasive carcinoma. Interventions: Six women with preoperative diagnosis by cervical conization and clinical stage IA1 underwent laparoscopic hysterectomy with 59.16 minutes operative time and 4.1 days hospital stay. Other six women with clinical stage Ia2-Ib1 underwent laparoscopic radical hysterectomy plus pelvic lymphadenectomy with operative time 3 hours and 58 minutes, and hospital stay of 10.1 days. Main outcome measures: Clinical cancer cure. Results: All diagnoses were confirmed by the surgical specimen and all were theoretically cured (negative margins, negative lymph nodes); one patient had complications that required prolonged stay (8.3%). Conclusions: Total laparoscopic hysterectomy and laparoscopic radical hysterectomy plus pelvic lymphadenectomy can be performed faster and more radically compared with conventional laparotomy. Both are feasible and safe interventions that ensure cure in microinvasive cervical carcinoma.

  13. Uterine fibromyolipoma

    International Nuclear Information System (INIS)

    Lipomatous tumors of the uterus are uncommon. Because of the fatty nature of those tumors, digital imaging techniques may provide the preoperative diagnosis. A case of uterine fibromyolipoma is reported, documented by both ultrasound (US) and computed tomography (CT), in which the diagnosis was strongly suggested by the US and CT findings. (author). 8 refs.; 2 figs

  14. Impact of curie-therapy timing in the treatment of cervical cancer; Impact du timing de la curietherapie dans le traitement du cancer du col uterin

    Energy Technology Data Exchange (ETDEWEB)

    Kochbati, L.; Bouzid, N.; Saidi, I.; Nasr, C.; Messai, T.; Hentati, D.; Gargouri, W.; Besbes, M.; Maalej, M. [Service de radiotherapie, institut Salah-Azaiz, Tunis (Tunisia)

    2011-10-15

    Curie-therapy conventionally comes before surgery in the treatment of cervical cancer, either alone or after a concomitant chemotherapy. The authors report a study of the impact of a reverse sequence (surgery before curie-therapy) on the exeresis quality and on the evolution of operable tumours. Among women treated between 2004 and 2009, 40 have been identified who had surgery before curie-therapy. Ages, tumour stages, average doses, and treatment procedures are discussed. The notably high rate of vaginal sections could be reduced or avoided by using the conventional protocol (curie-therapy before surgery). Short communication

  15. Prevalence of micronuclei in exfoliated uterine cervical cells from patients with risk factors for cervical cancer / Prevalência de micronúcleos em células esfoliativas do colo uterino de pacientes com fatores de risco para o câncer de colo uterino

    Scientific Electronic Library Online (English)

    Lízia Maria Franco dos Reis, Campos; Francisca da Luz, Dias; Lusânia Maria Greggi, Antunes; Eddie Fernando Candido, Murta.

    2008-11-01

    Full Text Available CONTEXTO E OBJETIVO: O câncer do colo uterino é uma das mais freqüentes neoplasias na mulher. O exame de Papanicolaou é o método mais comum e econômico para rastreamento. As células esfoliativas epiteliais podem ser úteis para o monitoramento de pacientes expostas a fatores de risco para o câncer. O [...] objetivo foi analisar a prevalência de micronúcleos em células esfoliativas da mucosa cervical uterina e associar com fatores de risco para o câncer de colo uterino. TIPO DE ESTUDO E LOCAL: Estudo transversal analítico, no Instituto de Pesquisa em Oncologia (IPON). MÉTODOS: Células esfoliativas do colo uterino foram obtidas de 101 pacientes ambulatoriais entre setembro/2004 e novembro/2005. As células foram coletadas usando espátula de Ayre e transferidas para um tubo de ensaio com soro fisiológico 0,9% para o teste do micronúcleo. Informações obtidas das pacientes foram: idade, hábitos (fumo e número de parceiros sexuais), métodos contraceptivos, história de doença sexualmente transmissível e uso de terapia hormonal. Células foram analisadas com magnificação de 1000 X e os micronúcleos contados em 1.000 células epiteliais por paciente. RESULTADOS: A comparação do grupo de pacientes fumantes ativas (7,9 ± 7,8) e passivas (7,2 ± 10,6) versus não fumantes (3,7 ± 5,1); alcoolismo e não alcoolismo (7,8 ± 1,4 e 6,9 ± 10,1); citologia inflamatória e citologia normal (10,7 ± 10,5 e 1,3 ± 1,7); neoplasia intraepitelial cervical (NIC) I, II e III e a ausência de NIC, respectivamente, (4,3 ± 4,3; 10,6 ± 5,3; 22,7 ± 11,9 e 1.3 ± 1.4) mostrou maior prevalência de micronúcleos (P Abstract in english CONTEXT AND OBJECTIVE: Pap smears are the most common and inexpensive screening method for cervical cancer. We analyzed micronucleus prevalence in exfoliated cervical mucosa cells, to investigate associations between increased numbers of micronuclei and risk factors for cervical cancer. DESIGN AND S [...] ETTING: Analytical cross-sectional study, at Instituto de Pesquisa em Oncologia (IPON). METHODS: Exfoliated cervical cells were obtained from 101 patients between September 2004 and November 2005. Patients' ages, habits (passive or active smoking, alcoholism and numbers of sexual partners), age at first sexual intercourse, contraceptive methods used, histories of sexually transmitted diseases, use of hormone replacement therapy, numbers of pregnancies and abortions, inflammatory cytology and cervical intraepithelial neoplasia (CIN) were obtained. Cells were collected using Ayre spatulas, transferred to vials containing 0.9% saline solution for micronucleus tests and analyzed at 1000x magnification. The number of micronuclei in 1,000 epithelial cells per patient sample was counted. RESULTS: Comparisons between groups with active (7.9 ± 7.8) and passive (7.2 ± 10.6) smoking versus no smoking (3.7 ± 5.1); with/without alcoholism (7.8 ± 1.4 and 6.9 ± 10.1); with/without inflammatory cytology (10.7 ± 10.5 and 1.3 ± 1.7); and with CIN I, II and III and no CIN (respectively 4.3 ± 4.3, 10.6 ± 5.3, 22.7 ± 11.9 and 1.3 ± 1.4) found elevated micronucleus prevalence (P

  16. Radiation therapy of the uterine cancer

    International Nuclear Information System (INIS)

    Cervical and endometrial cancer of the uterus, and ovarian cancer are three major malignant diseases in gynecology in Japan. These diagnosis and therapy are almost established. In uterine cervical cancer, radiation therapy and surgery of these diseases are two main treatment methods, and both treatment results are almost the same. And radiation therapy is also used as postoperative treatment to patients with high risk factors. In endometrial cancer, surgery is main therapy. Radiation therapy is undergone only to medically inoperable cases preoperative radiation is widely carried out in Europe and America, but almost none in Japan. Postoperative irradiation is adapted to the cases with high risk factors. But recent advance of chemotherapy changes the importance of radiation therapy in such patients. I review the literatures of radiation therapy of uterine cervical cancer and of endometrial cancer. (author)

  17. Sterility of the uterine cavity.

    DEFF Research Database (Denmark)

    MØller, B R; Kristiansen, F V

    1995-01-01

    In a prospective open study the sterility of the uterine cavity was evaluated in 99 women admitted for hysterectomy. The indications for hysterectomy were in most cases persistent irregular vaginal bleeding and fibromyomas of the uterus. Samples for both aerobic and anaerobic bacteria, Chlamydia trachomatis, yeasts and viruses were taken preoperatively from the apex of the vagina and cervical os. Immediately after hysterectomy the uterus was opened under sterile conditions and samples obtained from the isthmus and fundus of the uterine cavity for microbiological examination. Wet smears were taken from the same sites. Nearly a quarter of all the patients harbored one or more microorganisms in the uterus, mostly Gardnerella vaginalis, Enterobacter and Streptococcus agalactiae. We found that in a significant number of cases, the uterine cavity is colonized with potentially pathogenic organisms which may play a causative role in endometritis. The results indicate that inflammation of the uterine cavity should be evaluated by hysteroscopic examination before hysterectomy is undertaken in patients with persistent irregular vaginal bleeding. Udgivelsesdato: 1995-Mar

  18. Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2)

    Energy Technology Data Exchange (ETDEWEB)

    Toita, Takafumi, E-mail: b983255@med.u-ryukyu.ac.jp [Department of Radiology, Graduate School of Medical Science, University of Ryukyus, Okinawa (Japan); Kato, Shingo [Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Niibe, Yuzuru [Department of Radiology, School of Medicine, Kitasato University, Sagamihara (Japan); Ohno, Tatsuya [Gunma University Heavy Ion Medical Center, Maebashi (Japan); Kazumoto, Tomoko [Department of Radiology, Saitama Cancer Center, Saitama (Japan); Kodaira, Takeshi [Department of Radiation Oncology, Aichi Cancer Center, Nagoya (Japan); Kataoka, Masaaki [Department of Radiology, National Shikoku Cancer Center, Ehime (Japan); Shikama, Naoto [Department of Radiation Oncology, Saku Central Hospital, Saku (Japan); Kenjo, Masahiro [Department of Radiation Oncology, Graduate School of Medical Science, Hiroshima University, Hiroshima (Japan); Tokumaru, Sunao [Department of Radiology, Saga University, Saga (Japan); Yamauchi, Chikako [Department of Radiation Oncology, Shiga Medical Center for Adults, Moriyama (Japan); Suzuki, Osamu [Department of Radiation Oncology, Osaka Medical Center for Cancer, Osaka (Japan); Sakurai, Hideyuki [Proton Medical Research Center and Tsukuba University, Tsukuba (Japan); Numasaki, Hodaka; Teshima, Teruki [Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Suita, Osaka (Japan); Oguchi, Masahiko [Department of Radiation Oncology, Cancer Institute Hospital, Tokyo (Japan); Kagami, Yoshikazu [Radiation Oncology Division, National Cancer Center Hospital, Tokyo (Japan); Nakano, Takashi [Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi (Japan); Hiraoka, Masahiro [Department of Radiation Oncology and Image-applied Therapy, Kyoto University, Graduate School of Medicine, Kyoto (Japan); Mitsuhashi, Norio [Department of Radiation Oncology, Tokyo Women' s Medical University, Tokyo (Japan)

    2012-01-01

    Purpose: To determine the efficacy of a definitive radiotherapy protocol using high-dose-rate intracavitary brachytherapy (HDR-ICBT) with a low cumulative dose schedule in nonbulky early-stage cervical cancer patients, we conducted a prospective multi-institutional study. Methods and Materials: Eligible patients had squamous cell carcinoma of the intact uterine cervix, Federation of Gynecologic Oncology and Obstetrics (FIGO) stages Ib1, IIa, and IIb, tumor size <40 mm in diameter (assessed by T2-weighted magnetic resonance imaging), and no pelvic/para-aortic lymphadenopathy. The treatment protocol consisted of whole-pelvis external beam radiotherapy (EBRT) of 20 Gy/10 fractions, pelvic EBRT with midline block of 30 Gy/15 fractions, and HDR-ICBT of 24 Gy/4 fractions (at point A). The cumulative biologically effective dose (BED) was 62 Gy{sub 10} ({alpha}/{beta} = 10) at point A. The primary endpoint was the 2-year pelvic disease progression-free (PDPF) rate. All patients received a radiotherapy quality assurance review. Results: Between September 2004 and July 2007, 60 eligible patients were enrolled. Thirty-six patients were assessed with FIGO stage Ib1; 12 patients with stage IIa; and 12 patients with stage IIb. Median tumor diameter was 28 mm (range, 6-39 mm). Median overall treatment time was 43 days. Median follow-up was 49 months (range, 7-72 months). Seven patients developed recurrences: 3 patients had pelvic recurrences (2 central, 1 nodal), and 4 patients had distant metastases. The 2-year PDPF was 96% (95% confidence interval [CI], 92%-100%). The 2-year disease-free and overall survival rates were 90% (95% CI, 82%-98%) and 95% (95% CI, 89%-100%), respectively. The 2-year late complication rates (according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer of Grade {>=}1) were 18% (95% CI, 8%-28%) for large intestine/rectum, 4% (95% CI, 0%-8%) for small intestine, and 0% for bladder. No Grade {>=}3 cases were observed for genitourinary/gastrointestinal late complications. Conclusions: These results suggest that definitive radiotherapy using HDR-ICBT with a low cumulative dose schedule (BED, 62 Gy{sub 10} at point A) can provide excellent local control without severe toxicity in nonbulky (<4-cm) early-stage cervical cancer.

  19. Computed Tomography-Based High-Dose-Rate Intracavitary Brachytherapy for Uterine Cervical Cancer: Preliminary Demonstration of Correlation Between Dose-Volume Parameters and Rectal Mucosal Changes Observed by Flexible Sigmoidoscopy

    International Nuclear Information System (INIS)

    Purpose: To compare the dose-volume histogram (DVH) parameters obtained by three-dimensional gynecologic brachytherapy planning with the rectosigmoid mucosal changes observed by flexible sigmoidoscopy. Methods and Materials: Between January 2004 and July 2005, 71 patients with International Federation of Gynecology and Obstetrics Stage IB-IIIB uterine cervical cancer underwent computed tomography-based high-dose-rate intracavitary brachytherapy. The total dose (external beam radiotherapy [RT] plus intracavitary brachytherapy) to the International Commission of Radiation Units and Measurements rectal point (ICRURP) and DVH parameters for rectosigmoid colon were calculated using the equivalent dose in 2-Gy fractions (?/? = 3 Gy). Sigmoidoscopy was performed every 6 months after RT, with the 6-scale scoring system used to determine mucosal changes. Results: The mean values of the DVH parameters and ICRURP were significantly greater in patients with a score of ?2 than in those with a score RP, 71 Gy?/?3 vs. 66 Gy?/?3, p = 0.02; D0.1cc, 93 Gy?/?3 vs. 85 Gy?/?3, p = 0.04; D1cc, 80 Gy?/?3 vs. 73 Gy?/?3, p = 0.02; D2cc, 75 Gy?/?3 vs. 69 Gy?/?3, p = 0.02). The probability of a score of ?2 showed a significant relationship with the DVH parameters and ICRURP (ICRURP, p = 0.03; D0.1cc, p = 0.05; D1cc, p = 0.02; D2cc, p = 0.02). Conclusion: Our preliminary data have shown that DVH values of the rectosigmoid colon obtained by computed tomography-based three-dimensional brachytherapy planning are reliable and predictive of score ?2 rectosigmoid mucosal changes

  20. A nomogram predicting the risks of distant metastasis following postoperative radiotherapy for uterine cervical carcinoma: A Korean radiation oncology group study (KROG 12-08)

    International Nuclear Information System (INIS)

    Purpose: To develop a nomogram predicting the risks of distant metastasis following postoperative adjuvant radiation therapy for early stage cervical cancer. Materials and methods: We reviewed the medical records of 1069 patients from ten participating institutions. Patients were divided into two cohorts: a training set (n = 748) and a validation set (n = 321). The demographic, clinical, and pathological variables were included in the univariate Cox proportional hazards analysis. Clinically established and statistically significant prognostic variables were utilized to develop a nomogram. Results: The model was constructed using four variables: histologic type, pelvic lymph node involvement, depth of stromal invasion, and parametrial invasion. This model demonstrated good calibration and discrimination, with an internally validated concordance index of 0.71 and an externally validated c-index of 0.65. Compared to FIGO staging, which showed a broad range in terms of distant metastasis, the developed nomogram can accurately predict individualized risks based on individual risk factors. Conclusions: The devised model offers a significantly accurate level of prediction and discrimination. In clinical practice it could be useful for counseling patients and selecting the patient group who could benefit from more intensive/further chemotherapy, once validated in a prospective patient cohort

  1. Antimicrobial factors in the cervical mucus plug

    DEFF Research Database (Denmark)

    Hein, Merete; Valore, Erika V

    2002-01-01

    The cervical mucus plug is positioned between the microbe-rich vagina and the normally sterile uterine cavity, which suggests a host defense function, but few relevant data are available. We analyzed the composition and antimicrobial activity of cervical mucus plugs.

  2. Intracavitary combined with CT-guided interstitial brachytherapy for locally advanced uterine cervical cancer. Introduction of the technique and a case presentation

    International Nuclear Information System (INIS)

    We report a new technique of brachytherapy consisting of intracavitary combined with computed tomography (CT)-guided interstitial brachytherapy for locally advanced cervical cancer. A Fletcher-Suit applicator and trocar point needles were used for performing high-dose rate brachytherapy under in-room CT guidance. First, a tandem and ovoids were implanted into the patient's vagina and uterus by conventional brachytherapy method. Based on clinical examination and MRI/CT imaging, operating radiation oncologists decided the positions of insertion in the tumor and the depth of the needles from the upper surface of the ovoid. Insertion of the needle applicator was performed from the vaginal vault inside the ovoid within the tumor under CT guidance. In treatment planning, dwell positions and time adaptations within the tandem and ovoids were performed first for optimization based on the Manchester system, and then stepwise addition of dwell positions within the needle was continued. Finally, dwell positions and dwell weights were manually modified until dose-volume constraints were optimally matched. In our pilot case, the dose of D90 to high-risk clinical target volume was improved from 3.5 Gy to 6.1 Gy by using our hybrid method on the dose-volume histogram. D1cc of the rectum, bladder and sigmoid colon by our hybrid method was 4.8 Gy, 6.4 Gy and 3.5 Gy, respectively. This method consists of advanced image-guided brachytherapy that can be performed safely and accurately. This approach has the potential of increasing target coverage, treated volume, and total dose without increasing the dose to organs at risk. (author)

  3. Alterações citopatológicas e fatores de risco para a ocorrência do câncer de colo uterino Alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero Citopathological alterations and risk factors for uterine cervical neoplasm

    Directory of Open Access Journals (Sweden)

    Simone Cristina Castanho Sabaini de Melo

    2009-12-01

    Full Text Available O objetivo do estudo foi verificar alterações citopatológicas e fatores de risco para o câncer de colo uterino em mulheres usuárias do Sistema Único de Saúde de um município de pequeno porte do norte do Paraná, de 2001 a 2006. Trata-se de um estudo observacional transversal descritivo. A coleta de dados foi realizada com os resultados dos exames, prontuários e entrevistas. Foram realizados 6.356 exames e 65(1,02% apresentaram alterações. Dos exames realizados, 4.869 (70,8% foram em mulheres de 25 a 59 anos. 38,5% dos exames apresentaram Neoplasia Intraepitelial Cervical (NIC I, 32,3% NIC II e 18,5% NIC I e Papiloma Vírus Humano (HPV. Foram entrevistadas 25 mulheres, a maioria apresentou algum fator de risco como: tabagismo, doenças sexualmente transmissíveis, uso de anticoncepcional hormonal, número de parceiros, início precoce da atividade sexual. Conclui-se pela necessidade de ações educativas mais efetivas no sentido de reduzir as alterações principalmente entre as mulheres adolescentes.El objetivo del estudio fue verificar alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero en mujeres atendidas por el Sistema Único de la Salud de una ciudad de pequeño porte en la Región Norte de la Provincia del Paraná, Brasil en el período de 2001 al 2006. Se trata de un estudio observacional transversal descriptivo. La colección de los datos fue realizada con los resultados de los exámenes, prontuarios y entrevistas. Fueron realizados 6.356 exámenes y 65(1,02% presentaron alteraciones. De los exámenes hechos 4.869 (70,8% fue compuesto de mujeres con edad entre los 25 a los 59 años. Un total de 38,5% de los exámenes presentaron Neoplasia Intra-epitelial del Cuello Uterino (NIC I, 32,3% NIC II y 18,5% NIC I y Virus de Papiloma Humano (HPV. Fueron entrevistadas 25 mujeres, la mayoría presentó factores de riesgo como: tabaquismo, enfermedades de transmisión sexual, uso de anticonceptivo hormonal, número de parejas sexuales, inicio precoz de la actividad sexual. Concluyese ser necesarias acciones educativas para efectivamente producir la reducción de las alteraciones antes de todo entre mujeres más jóvenes.The aim of the present study was to verify the occurrence of citopathological alterations and risk factors of Uterine Cervical Neoplasm in women attended by SUS - the Public Healthcare System - in a district situated in the North of Paraná State, Brazil from 2001 to 2006. It was a descriptive transversal observational study. The data collection consisted in collection of test results from medical records and interviews. It was achieved 6.356 tests and, 1.02% (65 of the women examined presented alterations. From the tests made 4.869 (70,8% were from women aged between 25 and 59 years. And 38,5% of the tests presented Cervical Intraepithelial Neoplasm (CIN I, 32,3% CIN II, 18,5% CIN I and Human Papiloma Virus (HPV. It was interviewed 25 women from the total sample. Most of them presented a risk factor as: smoking habits, sexually transmitted diseases, use of hormonal contraceptive, number of sexual partners, early sexual intercourse. This study concludes that is required educative and more effective actions in order to reduce the alterations, meanly among teenagers.

  4. Alterações citopatológicas e fatores de risco para a ocorrência do câncer de colo uterino / Citopathological alterations and risk factors for uterine cervical neoplasm / Alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero

    Scientific Electronic Library Online (English)

    Simone Cristina Castanho Sabaini de, Melo; Letícia, Prates; Maria Dalva de Barros, Carvalho; Sonia Silva, Marcon; Sandra Marisa, Pelloso.

    2009-12-01

    Full Text Available O objetivo do estudo foi verificar alterações citopatológicas e fatores de risco para o câncer de colo uterino em mulheres usuárias do Sistema Único de Saúde de um município de pequeno porte do norte do Paraná, de 2001 a 2006. Trata-se de um estudo observacional transversal descritivo. A coleta de d [...] ados foi realizada com os resultados dos exames, prontuários e entrevistas. Foram realizados 6.356 exames e 65(1,02%) apresentaram alterações. Dos exames realizados, 4.869 (70,8%) foram em mulheres de 25 a 59 anos. 38,5% dos exames apresentaram Neoplasia Intraepitelial Cervical (NIC) I, 32,3% NIC II e 18,5% NIC I e Papiloma Vírus Humano (HPV). Foram entrevistadas 25 mulheres, a maioria apresentou algum fator de risco como: tabagismo, doenças sexualmente transmissíveis, uso de anticoncepcional hormonal, número de parceiros, início precoce da atividade sexual. Conclui-se pela necessidade de ações educativas mais efetivas no sentido de reduzir as alterações principalmente entre as mulheres adolescentes. Abstract in spanish El objetivo del estudio fue verificar alteraciones citopatológicas y factores de riesgo para la ocurrencia del cáncer de cuello de útero en mujeres atendidas por el Sistema Único de la Salud de una ciudad de pequeño porte en la Región Norte de la Provincia del Paraná, Brasil en el período de 2001 al [...] 2006. Se trata de un estudio observacional transversal descriptivo. La colección de los datos fue realizada con los resultados de los exámenes, prontuarios y entrevistas. Fueron realizados 6.356 exámenes y 65(1,02%) presentaron alteraciones. De los exámenes hechos 4.869 (70,8%) fue compuesto de mujeres con edad entre los 25 a los 59 años. Un total de 38,5% de los exámenes presentaron Neoplasia Intra-epitelial del Cuello Uterino (NIC) I, 32,3% NIC II y 18,5% NIC I y Virus de Papiloma Humano (HPV). Fueron entrevistadas 25 mujeres, la mayoría presentó factores de riesgo como: tabaquismo, enfermedades de transmisión sexual, uso de anticonceptivo hormonal, número de parejas sexuales, inicio precoz de la actividad sexual. Concluyese ser necesarias acciones educativas para efectivamente producir la reducción de las alteraciones antes de todo entre mujeres más jóvenes. Abstract in english The aim of the present study was to verify the occurrence of citopathological alterations and risk factors of Uterine Cervical Neoplasm in women attended by SUS - the Public Healthcare System - in a district situated in the North of Paraná State, Brazil from 2001 to 2006. It was a descriptive transv [...] ersal observational study. The data collection consisted in collection of test results from medical records and interviews. It was achieved 6.356 tests and, 1.02% (65) of the women examined presented alterations. From the tests made 4.869 (70,8%) were from women aged between 25 and 59 years. And 38,5% of the tests presented Cervical Intraepithelial Neoplasm (CIN) I, 32,3% CIN II, 18,5% CIN I and Human Papiloma Virus (HPV). It was interviewed 25 women from the total sample. Most of them presented a risk factor as: smoking habits, sexually transmitted diseases, use of hormonal contraceptive, number of sexual partners, early sexual intercourse. This study concludes that is required educative and more effective actions in order to reduce the alterations, meanly among teenagers.

  5. UTERINE DYDELPHYS WITH PREGNANCY IN RIGHT CORNU

    Directory of Open Access Journals (Sweden)

    Mandavi

    2014-06-01

    Full Text Available Uterus Didelphys is also known as duplicated uterus. It is an embryological abnormality resulting from complete failure of fusion of Mullerian ducts. There is presence of two uterine horns and two cervices with no communication between endometrial and endocervical cavities. We report the case in our institute of single viable pregnancy in right sided uterine body of didelphic uterus. She was an unbooked case and baby was delivered at twenty nine weeks of gestation by caesarean section as she reported to us with preterm labour with breech presentation. She had an uncomplicated post-operative period

  6. Selective uterine arterial embolization of uterine myoma

    International Nuclear Information System (INIS)

    Objective: Study the value of clinical application of Baiji and absorbable Gelatin in embolizing uterine myoma together with its effect, side effect and complication. Methods: 21 women with uterine myoma undergoing selective uterine arterial embolization by Seldinger's technique were studied. After retrograde trans-femoral introduction of a 5 french catheter, the uterine arteries were successively catheterized. Baiji and absorbable Gelatin sponge particles were injected through free flow until devasculariztion. Results: Uterine myomas blood supply came from bilateral uterine arteries demonstrated by angiography. All the supplying artery images disappeared after the embolization. 3-6 months follow-up study showed: a marked reduction in the size of myomata by 38%-90%. Clinical symptoms were improved. There was one failure cas and then underwent uterotomy due to infection. Conclusions: The short-term effect of using Baiji and absorbable Gelatin for embolizing uterine myoma is clinically significant, while long-term effects is still waiting for research

  7. Tendência da mortalidade por câncer do útero no Município de São Paulo entre 1980 e 1999 Mortality trends from uterine cervical cancer in the city of São Paulo from 1980 to 1999

    Directory of Open Access Journals (Sweden)

    Luiz Augusto Marcondes Fonseca

    2004-02-01

    Full Text Available O câncer do colo do útero apresenta grande incidência em algumas cidades brasileiras e considerável mortalidade em países em desenvolvimento, não obstante a disponibilidade já antiga de teste de rastreamento. O presente estudo visou avaliar a tendência da mortalidade por câncer de colo do útero, de corpo do útero e por câncer do útero não especificado, no Município de São Paulo, entre 1980 e 1999, por meio do exame das taxas brutas, idade-específica e ajustadas por idade. Os resultados mostraram discreta redução da mortalidade por câncer do colo do útero, queda da mortalidade por câncer de útero não especificado e aumento da mortalidade por câncer do corpo do útero. Conclui-se que a queda da mortalidade por câncer do útero não especificado sinaliza uma melhora na precisão do diagnóstico clínico e na qualidade do preenchimento do atestado de óbito, e indica aumento de cobertura do teste de Papanicolaou.Uterine cervical cancer shows a higher incidence in some Brazilian cities. It is a common cause of death in women from developing countries, despite the longstanding availability of an effective screening test, the Pap smear. This study aimed to evaluate the temporal trends of crude, age-adjusted, and age-specific mortality rates from cervical cancer, endometrial cancer, and cancer of the uterus not otherwise specified (NOS in the city of São Paulo from 1980 to 1999. Results showed a slight reduction in cervical cancer rates, a decrease in NOS uterine cancer rates, and an increase in endometrial cancer mortality rates. The fall in mortality from NOS uterine cancer indicates an improvement in diagnostic accuracy and quality of information on death certificates and may point to an increase in coverage of cervical cancer screening using the Pap smear.

  8. Uterine health and disorders.

    Science.gov (United States)

    Lewis, G S

    1997-05-01

    Nonspecific uterine infections reduce the reproductive efficiency of cows and the profit potential of dairy farms. Fortunately, most cows do not develop severe uterine infections. The term uterine infection indicates that the uterus is contaminated with pathogenic organisms. Actinomyces pyogenes, either alone or with other bacteria, is often associated with uterine infections. When A. pyogenes was isolated from uterine fluids after d 21 postpartum, cows developed severe endometritis and were infertile at first service. However, the exact causes of uterine infections are unknown but are associated with several factors. Cows with dystocia, retained placenta, twins or still-births, and various metabolic disorders are more likely to develop metritis than are other cows. Aberrant immune function before and after calving seems to predispose cows to severe uterine infections. Few cows die from uterine infections, but cows with uterine infections are more likely to be culled for poor reproductive performance. Also, uterine infections can reduce milk production, and some treatments contaminate milk. Because they are nonspecific, uterine infections are difficult to prevent; attention to sanitation and periparturient hygiene, especially during assisted calving, may be the best defense. Evidence that aberrant immuno function predisposes cows to uterine infections indicates that methods for regulating immune function in periparturient cows have the potential for preventing or treating uterine infections. PMID:9178140

  9. Cervical dysplasia

    Science.gov (United States)

    ... offered to you. This vaccine prevents many cervical cancers. ... Early diagnosis and prompt treatment cures most cases of cervical dysplasia. However, the condition may return. Without treatment, severe cervical dysplasia may change into cervical cancer.

  10. Uterine artery embolization - discharge

    Science.gov (United States)

    Uterine fibroid embolization - discharge; UFE - discharge; UAE - discharge ... You had uterine artery embolization (UAE). UAE is a procedure to treat fibroids using radiology instead of surgery. During the procedure, the blood supply of the fibroids ...

  11. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... old. She has very symptomatic uterine fibroids, very heavy menstrual periods. Her periods last on the order ... we see in women with uterine fibroids is heavy bleeding. In fact, some of our patients have ...

  12. Runoff erosion

    OpenAIRE

    EVELPIDOU, NIKI; Cordier, Stephane; Merino, Agustin (Ed.); Figueiredo, Tomás; Centeri, Csaba

    2013-01-01

    Table of Contents PART I – THEORY OF RUNOFF EROSION CHAPTER 1 - RUNOFF EROSION – THE MECHANISMS CHAPTER 2 - LARGE SCALE APPROACHES OF RUNOFF EROSION CHAPTER 3 - MEASURING PRESENT RUNOFF EROSION CHAPTER 4 - MODELLING RUNOFF EROSION CHAPTER 5 - RUNOFF EROSION AND HUMAN SOCIETIES: THE INFLUENCE OF LAND USE AND MANAGEMENT PRACTICES ON SOIL EROSION PART II - CASE STUDIES CASE STUDIES – INTRODUCTION: RUNOFF EROSION IN MEDITERRANEAN AREA CASE STUDY 1: Soil Erosion Risk...

  13. High signals in the uterine cervix on T2-weighted MRI sequences

    Energy Technology Data Exchange (ETDEWEB)

    Graef, De M.; Karam, R.; Daclin, P.Y.; Rouanet, J.P. [Department of Radiology, C.M.C. Beausoleil, 119 avenue de Lodeve, 34000 Montpellier (France); Juhan, V. [Department of Radiology, C.H.U. Timone, 13000 Marseille (France); Maubon, A.J. [Department of Radiology, C.H.U. Dupuytren, 87000 Limoges (France)

    2003-01-01

    The aim of this pictorial review was to illustrate the normal cervix appearance on T2-weighted images, and give a review of common or less common disorders of the uterine cervix that appear as high signal intensity lesions on T2-weighted sequences. Numerous aetiologies dominated by cervical cancer are reviewed and discussed. This gamut is obviously incomplete; however, radiologists who perform MR women's imaging should perform T2-weighted sequences in the sagittal plane regardless of the indication for pelvic MR. Those sequences will diagnose some previously unknown cervical cancers as well as many other unknown cervical or uterine lesions. (orig.)

  14. High signals in the uterine cervix on T2-weighted MRI sequences

    International Nuclear Information System (INIS)

    The aim of this pictorial review was to illustrate the normal cervix appearance on T2-weighted images, and give a review of common or less common disorders of the uterine cervix that appear as high signal intensity lesions on T2-weighted sequences. Numerous aetiologies dominated by cervical cancer are reviewed and discussed. This gamut is obviously incomplete; however, radiologists who perform MR women's imaging should perform T2-weighted sequences in the sagittal plane regardless of the indication for pelvic MR. Those sequences will diagnose some previously unknown cervical cancers as well as many other unknown cervical or uterine lesions. (orig.)

  15. High signals in the uterine cervix on T2-weighted MRI sequences.

    Science.gov (United States)

    De Graef, M; Karam, R; Juhan, V; Daclin, P Y; Maubon, A J; Rouanet, J P

    2003-01-01

    The aim of this pictorial review was to illustrate the normal cervix appearance on T2-weighted images, and give a review of common or less common disorders of the uterine cervix that appear as high signal intensity lesions on T2-weighted sequences. Numerous aetiologies dominated by cervical cancer are reviewed and discussed. This gamut is obviously incomplete; however, radiologists who perform MR women's imaging should perform T2-weighted sequences in the sagittal plane regardless of the indication for pelvic MR. Those sequences will diagnose some previously unknown cervical cancers as well as many other unknown cervical or uterine lesions. PMID:12541119

  16. Accurate and economical intracavitary endocurietherapy in the treatment of uterine cervix cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, P.P.; Good, R.R.

    1986-01-01

    A modified afterloading cervical applicator and intracavitary endocurietherapy application technique eliminates several problems associated with the Henschke cervical applicator, and conventional preloading technique. The Kumar cervical applicator minimizes patient discomfort, and improves patient mobility while reducing the tendency of the applicator to rotate during the 40 to 50 hours of uterine intracavitary endocurietherapy. The use of hygroscopic laminaria tent for gradual cervical dilatation in place of manual cervical dilatation, and the use of inflatable Foley balloon threaded onto the tandem instead of vaginal packing, to separate the /sup 137/Cesium sources away from the rectum and bladder, eliminate the need of general anesthesia for the majority of patients undergoing intracavitary endocurietherapy.

  17. Accurate and economical intracavitary endocurietherapy in the treatment of uterine cervix cancer

    International Nuclear Information System (INIS)

    A modified afterloading cervical applicator and intracavitary endocurietherapy application technique eliminates several problems associated with the Henschke cervical applicator, and conventional preloading technique. The Kumar cervical applicator minimizes patient discomfort, and improves patient mobility while reducing the tendency of the applicator to rotate during the 40 to 50 hours of uterine intracavitary endocurietherapy. The use of hygroscopic laminaria tent for gradual cervical dilatation in plate of manual cervical dilatation, and the use of inflatable Foley balloon threaded onto the tandem instead of vaginal packing, to separate the 137Cesium sources away from the rectum and bladder, eliminate the need of general anesthesia for the majority of patients undergoing intracavitary endocurietherapy. (orig.)

  18. Modification of conservative treatment of heterotopic cervical pregnancy by Foley catheter balloon fixation with cerclage sutures at the level of the external cervical os: a case report

    Directory of Open Access Journals (Sweden)

    Vujisic Sanja

    2010-07-01

    Full Text Available Abstract Introduction Conservative treatment of a heterotopic cervical pregnancy was performed with a modification of the fixation of a Foley catheter at the level of the external cervical os, followed by the ligature of the descending cervical branches of the uterine arteries and systemic methotrexate application. Case presentation A 34-year-old Caucasian woman was diagnosed with double gestation after 6 weeks of in vitro fertilization treatment. A gynecological examination and color Doppler ultrasound scan revealed intra-uterine and cervical gestational sacs both containing live fetuses. A Foley catheter balloon was inserted into the cervical canal, inflated and fixed by a cerclage suture at the level of the external cervical os, followed by ligation of the descending cervical branches of the uterine arteries. Systemic methotrexate was applied. Three days after removal of the Foley catheter, an evacuation of the intra-uterine gestational sac was performed. Hemorrhage from the implantation site was controlled immediately and a pregnancy termination was successfully performed. The procedure was uneventful and our patient was discharged with a preserved uterus. Conclusions Conservative treatment of cervical pregnancy using a Foley catheter balloon is more efficacious if the Foley catheter balloon is attached in the correct position with a cerclage suture at the level of the external os, followed by ligation of the descending cervical branches of the uterine arteries, thereby exerting maximal pressure on the bleeding vessels.

  19. Estrogen and ER?: Culprits in Cervical Cancer?

    OpenAIRE

    Chung, Sang-Hyuk; Franceschi, Silvia; Paul F. Lambert

    2010-01-01

    Estrogen and its receptors are implicated in the promotion and prevention of various cancers. While the uterine cervix is highly responsive to estrogen, the role of estrogen in cervical cancer, which is strongly associated with human papillomavirus (HPV) infections, is poorly understood. Recent studies in HPV transgenic mouse models provide evidence that estrogen and its nuclear receptor promote cervical cancer in combination with HPV oncogenes. While epidemiological studies further support t...

  20. Progesterone Signaling Inhibits Cervical Carcinogenesis in Mice

    OpenAIRE

    Yoo, Young A; Son, Jieun; Mehta, Fabiola F.; DeMayo, Francesco J; Lydon, John P.; Chung, Sang-Hyuk

    2013-01-01

    Human papillomavirus is the main cause of cervical cancer, yet other nonviral cofactors are also required for the disease. The uterine cervix is a hormone-responsive tissue, and female hormones have been implicated in cervical carcinogenesis. A transgenic mouse model expressing human papillomavirus oncogenes E6 and/or E7 has proven useful to study a mechanism of hormone actions in the context of this common malignancy. Estrogen and estrogen receptor ? are required for the development of cervi...

  1. Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma

    OpenAIRE

    Fukushima Masanori; Teramukai Satoshi; Tada Harue; Sasaki Hiroshi

    2009-01-01

    Abstract Background Lymph node dissection has proven prognostic benefits for patients with ovarian or uterine carcinoma; however, one of the complications associated with this procedure is lymphedema. We aimed to identify the factors that are associated with the occurrence of lymphedema after lymph node dissection for the treatment of ovarian or uterine carcinoma. Methods A total of 694 patients with histologically confirmed ovarian (135 patients) or uterine cancer (258 with cervical cancer, ...

  2. Malignant mixed mullerian tumor arising from the uterine cervix: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Jong Joon; Shim, Jae Chan; Lee, Kyoung Eun; Lee, Ghi Jai; Kim, Ho Kyun; Suh, Jung Ho; Lee, Hye Kyung [Seoul Paik Hospital/Inje Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-10-15

    Malignant mixed mullerian tumors (MMMTs) are a rare uterine tumor and contribute to approximately 1-3% of all corpus malignant tumors. MMMTs are usually in the uterine corpus, but can also arise from the uterine cervix, vagina, ovaries and fallofian tubes. MMMTs of the uterine cervix are extremely rare. MMMTs are highly malignant and tend to maintain a rapid growth and exhibit a high rate of recurrence. Therefore, the prognosis of patients diagnosed with these types of tumors is extremely poor. We report a rare case of a malignant mixed mullerian tumor arising from the uterine cervix and introduce CT and MRI findings. CT and magnetic resonance findings of the uterine cervical MMMT in our case show highly aggressive features, such as parametrial involvement, pelvic and paraaortic lymphadenopathy, and distant metastasis and high enhancement.

  3. A Case of Lymphoepithelioma-like Carcinoma in the Uterine Cervix.

    Science.gov (United States)

    Takebayashi, Kanetoshi; Nishida, Masakazu; Matsumoto, Harunobu; Nasu, Kaei; Narahara, Hisashi

    2015-02-11

    Lymphoepithelioma-like carcinoma occurring in the reproductive organs is a rare variant of squamous cell carcinoma, and this tumor of the uterine cervix accounts for 0.7% of all primary cervical uterine neoplasms. Associations with Epstein-Barr virus (EBV) and human papilloma virus (HPV) have been demonstrated in some studies. Some investigators suggested that EBV has an important role in the initiation of lymphoepitheliomalike carcinoma in Asian women. Here we report the case of a 45-year-old Japanese woman, gravida 2 and parity 2. She was admitted due to severe atypical genital bleeding caused by uterine cervical cancer. A >60-mm tumor was detected at the uterine cervix, and no distal metastasis or swallowing of lymph nodes was revealed by magnetic resonance imaging and a computed tomography scan. The cervical cancer stage FIGO Ib2 was diagnosed, and a radical hysterectomy was performed for this malignant tumor. The in situ hybridization for EBV was negative. HVP infection was strongly suspected because the squamous cell carcinoma was observed macroscopically in the uterine cervix. The prognosis of uterine lymphoepithelioma-like carcinoma is thought to be better than those of other cervical cancer types, but careful follow-up at fixed intervals is recommended. The patient has been followed up for 4 months since her surgery, and no evidence of recurrence has been detected. PMID:25918614

  4. Chemotherapy and immunotherapy for cervical cancer

    International Nuclear Information System (INIS)

    The treatment of uterine cervical cancer with the combined use of radiotherapy and an immunopotentiator, PSK. Clinical experiences suggest that PSK possesses a stimulatory activity on the radiation effect. Although the mechanism is not yet clear, it is speculated that it is due to the host-mediated immunopotentiating activity of PSK. (Auth.)

  5. Prevalence of cervicitis in dairy cows and its effect on reproduction.

    Science.gov (United States)

    Hartmann, D; Rohkohl, J; Merbach, S; Heilkenbrinker, T; Klindworth, H P; Schoon, H A; Hoedemaker, M

    2016-01-15

    The objective of this study was to determine whether cervicitis in dairy cows is an independent disease or occurs concomitantly with inflammation of the uterus, and to clarify possible effects of cervicitis on reproductive performance. Dairy cows (n = 416) from 33 dairy farms were examined by rectal palpation and vaginoscopy between 42 and 50 days postpartum. Inclusion criteria for this study were absence of abnormal vaginal discharge and abnormalities of the uterus (fluctuation) at rectal palpation. Cervicitis was diagnosed when the second cervical fold was swollen and prolapsed with (C2) or without (C1) reddening. Cytobrush samples from the uterus (n = 370) and the cervix (n = 402) were collected, and the percentage of neutrophils in the uterus (PMNU) and the cervix as indicators of inflammation (threshold: ?5%) was determined. In addition, endometrial biopsies for histology were collected, 300 of which were suitable for evaluation. Cervicitis (C1/C2) was diagnosed in 253 of 416 (60.8%) of cows. Of these, the prolapsed cervical mucosa was hyperemic (C2) in 29.1% of cases. Of 370 available uterine cytology samples, 221 cows had a clinical cervicitis; however, 170 (76.9%) had PMNU less than 5%. Of 300 uterine histologic examinations, 82 (27.3%) did not reveal any abnormalities; the remaining cows either had uterine inflammation and/or degenerative uterine changes such as endometriosis and angiosclerosis. Furthermore, of 300 biopsied animals, 184 revealed a cervicitis (C1/C2); however, 30.4% of these animals had no histopathologic uterine findings. For further analysis, only animals either without histopathologic findings and normal uterine cytology or with solely endometritis (defined as PMNU ? 5% and/or positive histopathology of the uterine tissue) were evaluated (n = 157). Of these, 95 cows had cervicitis. Unexpectedly, 63 of 95 (66.3%) cows had cervicitis without endometritis. With regard to reproductive performance, days to first service were not affected by cervicitis. Number of days open in animals with cervicitis but without endometritis tended to be lower than in cows with cervicitis plus endometritis (P = 0.092). Also, number of days open relative to percentage of neutrophils greater than 5% was lower when the cervical compared to the uterine mucosa was affected (P < 0.05). Total conception and pregnancy rates of animals 200 days into lactation decreased significantly in cows with severe cervical inflammation (C2). In conclusion, the results of this study suggested that cervicitis occurs independent of endometritis, and a higher degree of cervicitis is associated with poorer reproductive performance. PMID:26483309

  6. Intra-uterine insemination with prepared sperm vs. unprepared first split ejaculates. A randomized study.

    Science.gov (United States)

    Goldenberg, M; Rabinovici, J; Bider, D; Lunenfeld, B; Blankstein, J; Weissenberg, R

    1992-01-01

    In this randomized prospective study, we determined the conception rate following intra-uterine insemination with washed and prepared sperm, or with the first portion of a split ejaculate, in couples with longstanding male (n = 27, 70 treatment cycles) or cervical infertility (n = 14, 29 treatment cycles). Folliculogenesis and ovulation were induced by human menopausal gonadotropin and human chorionic gonadotropin. Significantly more couples conceived in the male infertility group following intra-uterine insemination with washed sperm, than after intra-uterine insemination with split ejaculate (9 vs. 2; P less than 0.05), while no difference in pregnancy rate (2 vs. 2) was found by the two intra-uterine insemination methods in the cervical infertility group. PMID:1503250

  7. Uterine Leiomyoma: Hysterosalpingographic Appearances

    Directory of Open Access Journals (Sweden)

    Firoozeh Ahmadi

    2008-01-01

    Full Text Available Uterine leiomyoma is the most common benign tumor of genital tract. The etiology of myomasis unknown. Leiomyoma shows a broad spectrum of radiographic appearances depending on thenumber, size, and location of the tumor. The diagnostic method for uterine leiomyomas is basedprimarily on the clinical situation. Despite of the varied diagnostic options such as; transvaginalsonography, sonohysterography, hysteroscopy, laparoscopy and MRI; hysterosalpingography isstill one of the valuable imaging methods for identification of uterine leiomyoma.The various features of the proved leiomyoma are illustrated in this pictorial review. The incidence,risk factors and clinical features will also be discussed briefly.

  8. Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia

    Directory of Open Access Journals (Sweden)

    Yaliana Tafurt-Cardona

    2012-02-01

    Full Text Available Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron entrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %, 36 citología anormal (2 % y 638 cambios celulares reactivos asociados a inflamación (37 %. Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país.Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire to collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %, 36 abnormal cytology (2 % and 638 reactive cellular changes associated with inflammation (37 %. The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

  9. Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis

    Scientific Electronic Library Online (English)

    José Roosevelt, Cavalcante; João Paulo Aguiar, Sampaio; João Tarcísio Alves, Maia Filho; Renato Braga, Vieira; José, Eleutério Júnior; Roberto César Pereira, Lima Júnior; Ronaldo Albuquerque, Ribeiro; Paulo Roberto Carvalho, Almeida.

    2014-10-01

    Full Text Available PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases [...] of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer.

  10. Uterine Didelphys with blind hemivagina, hematocolpos, ipsilateral renal agenesis (UD-BHRA) and bilateral ovarian tumors : a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Young Rae; Choi, Byung Ik; Park, Hae Won; Kook, Shin Ho [Kangbuk Samsung Hospital, Seoul (Korea, Republic of)

    1998-03-01

    Uterine didelphys is a congenital malformation characterized by the presence of two separated hemiuteri and hemivaginas, due to lack of midfusion of the mullerian ducts. We report a case of UD-BHRA (uterine didelphys with blind hemivagina and ipsilateral renal agencies), a rare type of uterine dedelphys characterized by symptomatic unilateral hematocolpos due to blind hemivagina after menarche and ipsilateral renal agenesis. The MRI findings in 22-year-old woman with bilateral ovarian tumors demonstrated two separated uterine horns and cervical and vaginal canals, with left hematocolpos and left agenesis. (author). 7 refs., 1 fig.

  11. Uterine Fibroids Fact Sheet

    Science.gov (United States)

    ... be meeting your needs. Return to top FDA warning on power morcellators in treatment for uterine fibroids ... very heavy bleeding. This can be done with laser, wire loops, boiling water, electric current, microwaves, freezing, ...

  12. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... 000 uterine fibroid embolizations. Fibroids are common, benign tumors in women. They can range in size from ... come into this vessel and block off the tumor. It will then kill the tumor. So if ...

  13. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... uterine fibroids, very heavy menstrual periods. Her periods last on the order of eight days, four of ... I can quickly go back, we have this last image in our mind, if you will, that ...

  14. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... parts of it can actually break off and fall into the cavity. And a small percentage of ... fibroid, instead of shrinking, may break off and fall into the uterine cavity, in which case we ...

  15. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... make sure that we're not going too fast, slowly inject, only going forward into the uterine ... blockage is relieved, we don't inject too fast. And so, typically it's a relatively low-pressure ...

  16. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... a little background. Hysterectomies are the commonest performed surgery in the United States. And the commonest reason that that surgery occurs is for uterine fibroids. Over the past ...

  17. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... Cardiac and Vascular Institute, we've performed almost 1,000 uterine fibroid embolizations. Fibroids are common, benign ... embolization procedure. More contrast, please. Thanks, Dr. Powell. One thing I did want to mention. You heard ...

  18. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... and Vascular Institute, we've performed almost 1,000 uterine fibroid embolizations. Fibroids are common, benign tumors ... really on the order of one in 10,000. And so, for all intents and purposes, it's ...

  19. Radiotherapy in the treatment of a locally advanced cervical cancer: experience of the Casablanca Radiotherapy-Oncology centre; Radiotherapie dans le traitement du cancer du col uterin localement evolue: experience du centre de radiotherapie-oncologie de Casablanca

    Energy Technology Data Exchange (ETDEWEB)

    Bouchbika, Z.; Benchakroun, N.; Sellal, N.; Jouhadi, H.; Tawfiq, N.; Sahraoui, S.; Benider, A. [Service radiotherapie-oncologie, CHU Ibn-Rochd, Casablanca (Morocco)

    2011-10-15

    The authors report the assessment of the local control and relapse rates in a set of 70 patients who had been treated in 2004 and 2005 by radiotherapy associated or not with chemotherapy for a cervical cancer of stage IIbd, III or IVa according to the FIGO classification. The obtained results correspond to that published in literature. The authors expect that the improvement of radiotherapy techniques could improve these results. Short communication

  20. Prostaglandin treatment is associated with a withdrawal of progesterone and androgen at the receptor level in the uterine cervix

    OpenAIRE

    Ekman-Ordeberg Gunvor; Vladic Tomislav; Blesson Chellakkan S; Vladic-Stjernholm Ylva; Sahlin Lena

    2009-01-01

    Abstract Treatment with prostaglandin(PG)-E2 is clinically efficient for cervical priming. The aim of this study was to evaluate the impact of PG-E2 on the expression of the progesterone (PR), androgen (AR) and glucocorticoid (GR) receptors in human uterine cervix in prolonged pregnancy. The study groups were postterm nulliparous women with unripe cervices undergoing cervical priming with PG-E2 before labor induction. Responders (n = 12) who delivered vaginally were compared with non-responde...

  1. Avaliação da medida do comprimento do colo e da ausência do eco glandular endocervical para predição do parto pré-termo / Evaluation of risk for preterm delivery by measurement of uterine cervix and cervical gland area

    Scientific Electronic Library Online (English)

    Claudio Rodrigues, Pires; Antonio Fernandes, Moron; Rosiane, Mattar; Luiz, Kulay Júnior.

    2004-04-01

    Full Text Available OBJETIVO: verificar a prevalência do sinal eco glandular endocervical (EGE) e o comprimento cervical menor ou igual a 20 mm em gestantes entre a 21ª e a 24ª semana e comparar estes sinais ecográficos como fatores indicadores de parto pré-termo espontâneo. MÉTODOS: estudo prospectivo transversal no q [...] ual foram incluídas 361 gestantes da população geral, para realização de exame ultra-sonografico em idade gestacional entre a 21ª a 24ª semana. Os critérios de exclusão do estudo foram malformações müllerianas, gestações múltiplas, malformações fetais, óbito fetal, alterações da quantidade de líquido amniótico, placenta com inserção segmentar, antecedentes de cirurgia no colo uterino (conização, amputação, cerclagem) e procedimentos cirúrgicos durante a gestação. Após a realização do exame ultra-sonográfico obstétrico morfológico efetuado por via abdominal, seguiu-se o exame ecográfico por via vaginal para observação de uma faixa hipoecóica ou hiperecóica adjacente ao canal endocervical correpondente às glândulas do epitélio endocervical (EGE) e mensuração do comprimento cervical. As variáveis qualitativas são representadas por freqüência absoluta e relativa, ao passo que as variáveis quantitativas, por média, desvio-padrão, mediana e valores mínimo e máximo. A associação entre as variáveis qualitativas foi avaliada pelo teste c² ou teste exato de Fisher. Para cada variável estudada, foi calculado o risco relativo seguido do intervalo com 95% de confiança. A técnica de análise de regressão logística univariada foi utilizada para verificar, entre as variáveis estudadas, quais foram indicativas de parto pré-termo espontâneo. O nível de significância adotado foi de 95% (alfa = 5%) e descritivos (p) iguais ou inferiores a 0,05 foram considerados significantes. RESULTADOS: a incidência do parto pré-termo espontâneo foi de 5,0%. O comprimento do colo uterino revelou-se igual ou inferior a 20 mm em 3,3% da população estudada e em 27,8% das pacientes que apresentaram parto pré-termo espontâneo. A ausência do EGE foi detectada em 2,8% das pacientes estudadas e em 44,4% das pacientes que evoluíram para parto pré-termo espontâneo. A associação entre ausência do EGE e presença do colo curto revelou-se estatisticamente significante (p Abstract in english PURPOSE: to verify the prevalence of two sonographic findings, the cervical gland area (CGA) feature and the cervical length of less than 20 mm, and to compare these with the risk for premature delivery in pregnant women between 21 and 24 weeks' gestation. METHOD: this was a prospective, cross-secti [...] onal study in which 361 women were consecutively examined by transvaginal ultrasonography. Müllerian or other malformations, multiple gestations, fetal death, olygo- or polyhydramnios, marginal placenta previa, and conization, cerclage, amputation or other surgical procedures in the cervix, prior to or during pregnancy, were exclusion criteria. After the abdominal ultrasonographic morphological examination, we used transvaginal ultrasonography to measure the cervical length and to observe the presence of hyper- or hypoechoic area next to the endocervical canal, a feature characteristic of endocervical epithelium glands which is called CGA (cervical gland area). Qualitative variables are expressed as absolute and relative frequency. Quantitative variables are expressed as mean, median, standard deviation, minimum, and maximum values. Association between qualitative variables was detected by the c² test or by the Fisher exact test. For each variable, the relative risk and the 95% confidence interval (CI) were calculated. Logistic regression analysis was used to calculate the predictive values for premature delivery. Significance level was 95% (alpha = 5%), with descriptive (p) values equal or lower than 0.05 considered significant. RESULTS: spontaneous preterm delivery occurred in 5.0% of the patients. Cervical length was up to 20 mm in 3.3% of all studied patients and i

  2. Avaliação da medida do comprimento do colo e da ausência do eco glandular endocervical para predição do parto pré-termo Evaluation of risk for preterm delivery by measurement of uterine cervix and cervical gland area

    Directory of Open Access Journals (Sweden)

    Claudio Rodrigues Pires

    2004-04-01

    Full Text Available OBJETIVO: verificar a prevalência do sinal eco glandular endocervical (EGE e o comprimento cervical menor ou igual a 20 mm em gestantes entre a 21ª e a 24ª semana e comparar estes sinais ecográficos como fatores indicadores de parto pré-termo espontâneo. MÉTODOS: estudo prospectivo transversal no qual foram incluídas 361 gestantes da população geral, para realização de exame ultra-sonografico em idade gestacional entre a 21ª a 24ª semana. Os critérios de exclusão do estudo foram malformações müllerianas, gestações múltiplas, malformações fetais, óbito fetal, alterações da quantidade de líquido amniótico, placenta com inserção segmentar, antecedentes de cirurgia no colo uterino (conização, amputação, cerclagem e procedimentos cirúrgicos durante a gestação. Após a realização do exame ultra-sonográfico obstétrico morfológico efetuado por via abdominal, seguiu-se o exame ecográfico por via vaginal para observação de uma faixa hipoecóica ou hiperecóica adjacente ao canal endocervical correpondente às glândulas do epitélio endocervical (EGE e mensuração do comprimento cervical. As variáveis qualitativas são representadas por freqüência absoluta e relativa, ao passo que as variáveis quantitativas, por média, desvio-padrão, mediana e valores mínimo e máximo. A associação entre as variáveis qualitativas foi avaliada pelo teste c² ou teste exato de Fisher. Para cada variável estudada, foi calculado o risco relativo seguido do intervalo com 95% de confiança. A técnica de análise de regressão logística univariada foi utilizada para verificar, entre as variáveis estudadas, quais foram indicativas de parto pré-termo espontâneo. O nível de significância adotado foi de 95% (alfa = 5% e descritivos (p iguais ou inferiores a 0,05 foram considerados significantes. RESULTADOS: a incidência do parto pré-termo espontâneo foi de 5,0%. O comprimento do colo uterino revelou-se igual ou inferior a 20 mm em 3,3% da população estudada e em 27,8% das pacientes que apresentaram parto pré-termo espontâneo. A ausência do EGE foi detectada em 2,8% das pacientes estudadas e em 44,4% das pacientes que evoluíram para parto pré-termo espontâneo. A associação entre ausência do EGE e presença do colo curto revelou-se estatisticamente significante (pPURPOSE: to verify the prevalence of two sonographic findings, the cervical gland area (CGA feature and the cervical length of less than 20 mm, and to compare these with the risk for premature delivery in pregnant women between 21 and 24 weeks' gestation. METHOD: this was a prospective, cross-sectional study in which 361 women were consecutively examined by transvaginal ultrasonography. Müllerian or other malformations, multiple gestations, fetal death, olygo- or polyhydramnios, marginal placenta previa, and conization, cerclage, amputation or other surgical procedures in the cervix, prior to or during pregnancy, were exclusion criteria. After the abdominal ultrasonographic morphological examination, we used transvaginal ultrasonography to measure the cervical length and to observe the presence of hyper- or hypoechoic area next to the endocervical canal, a feature characteristic of endocervical epithelium glands which is called CGA (cervical gland area. Qualitative variables are expressed as absolute and relative frequency. Quantitative variables are expressed as mean, median, standard deviation, minimum, and maximum values. Association between qualitative variables was detected by the c² test or by the Fisher exact test. For each variable, the relative risk and the 95% confidence interval (CI were calculated. Logistic regression analysis was used to calculate the predictive values for premature delivery. Significance level was 95% (alpha = 5%, with descriptive (p values equal or lower than 0.05 considered significant. RESULTS: spontaneous preterm delivery occurred in 5.0% of the patients. Cervical length was up to 20 mm in 3.3% of all studied patients and in 27.8% of those who delivered spontaneously

  3. Cervical Cancer

    Science.gov (United States)

    ... the place where a baby grows during pregnancy. Cervical cancer is caused by a virus called HPV. The ... for a long time, or have HIV infection. Cervical cancer may not cause any symptoms at first. Later, ...

  4. Cervical spondylosis

    Science.gov (United States)

    ... caused by aging and chronic wear on the cervical spine. This includes the disks or cushions between the ... and the joints between the bones of the cervical spine. There may be abnormal growths or spurs on ...

  5. Importancia de los estudios de inmunohistoquímica en el diagnóstico y la evaluación pronóstica de la neoplasia intraepitelial y el cáncer cervical: Revisión / Importance of immunohistochemical studies in the diagnosis and the prognostic evaluation of cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix: Review

    Scientific Electronic Library Online (English)

    Jorge, García-Tamayo; Julia, Molina; Eduardo, Blasco-Olaetxea.

    2009-06-01

    Full Text Available Se evaluó la expresión de proteínas dependientes de genes en el epitelio cervical, en la neoplasia intraepitelial cervical (NIC) y en el carcinoma del cuello uterino (CC) a través de diversos estudios de inmunohistoquímica (IHQ). Se examinó la detección de ciertas proteínas como p53, bcl2, C-Myc, Ki [...] 67, Ciclinas, P16 INK4a, p21, p27, b-catenina, Wnt y MCM, en relación con la evolución de la neoplasia intraepitelial, el carcinoma cervical y la infección con el virus del papiloma humano (VPH). Se señaló como la actividad transcripcional de diversos genes provoca alteraciones de la heterocigosis y pérdida de regiones cromosómicas que influyen en la sobrexpresión de proteínas o en la pérdida parcial de la expresión de algunas glicoproteínas en la superficie celular por la activación de genes del VPH. Abstract in english Immunohistochemical studies in cervical intraepithelial neoplasia and cervical carcinoma are evaluated in this review. A variety of proteíns like p53, bcl2, C-Myc, Ki 67, Cyclines, P16 INK4a, p21, p27, b-catenin, Wnt and MCM, have been related to the development of cervical neoplasia and human papil [...] loma virus infection. It is described how transcriptional factors of genes induce loss of heterozygosity, numerical chromosome abnormality and inactivation of gene products or the partial loss of some membrane glycoproteins induced by oncogenic human papillomaviruses (HPV).

  6. Dermatan sulphate and mucin glycopeptides from the human uterine cervix

    DEFF Research Database (Denmark)

    Uldbjerg, N; Carlstedt, I; Ekman, G; Malmström, A; Ulmsten, U; Wingerup, L

    1983-01-01

    High molecular weight glycopeptides and glycosaminoglycans were isolated from the human uterine cervix. The major part of the material (82%) was derived from cervical mucins. The remainder contained hyaluronic acid (3%), heparan sulphate (2%) and dermatan sulphate (13%). Chondroitin sulphate and keratan sulphate were not present, but chondroitin sulphate-like segments were included in the dermatan sulphate. The composition of the cervix apart from the mucus-filled crypts is similar to that of ot...

  7. Cervical Cancer

    Centers for Disease Control (CDC) Podcasts

    2007-03-06

    Did you know that cervical cancer rates differ by race/ethnicity and region? Or that cervical cancer can usually be prevented if precancerous cervical lesions are found by a Pap test and treated? Find out how getting regular Pap tests can save a woman's life.  Created: 3/6/2007 by National Breast and Cervical Cancer Early Detection Program.   Date Released: 4/25/2007.

  8. The diagnostic value of transvaginal color Doppler ultrasound for cervical diseases

    International Nuclear Information System (INIS)

    Objective: To evaluate the diagnostic value of transvaginal color Doppler ultrasound for the cervical diseases. Method: Cases of cervical disease diagnosed and managed from 2003 to 2006 were included. Transvaginal color Doppler sonographic (TVS) findings, clinical treatments, pathologic results were followed up and analyzed. Results 70 cases of cervical disease were identified, including 40 cases of cervical cyst (35cases of Naboth cyst, 3 cases of endometriosis cyst), 5 cases of cervical polyps, 5 cases of cervical fibroma, 2 cases of uterine submucous myoma projecting to cervix, 2 cases of cervical pregnancy, 3 cases of cervical dysfunction, 15 cases of malignant tumor. The ultrasonic diagnosis was accordant to pathologic results in 97% patients. Conclusion: Transvaginal color Doppler ultrasound can make precise diagnosis for cervical diseases. It is the preferred method for the diagnosis of cervical diseases. (authors)

  9. Prevalência do exame preventivo de câncer do colo do útero em Rio Branco, Acre, Brasil, e fatores associados à não-realização do exame Prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and factors associated with non-participation in screening

    Directory of Open Access Journals (Sweden)

    Maria Fernanda de Sousa Oliveira Borges

    2012-06-01

    Full Text Available O objetivo do estudo foi determinar a prevalência autorreferida do exame preventivo de câncer do colo uterino em Rio Branco, Acre, Brasil, e avaliar fatores associados com a não realização do exame. Trata-se de estudo transversal de base populacional, composto por 772 mulheres de 18 a 69 anos residentes em Rio Branco, no período 2007 a 2008. Os dados foram analisados no programa Stata 10.0 e estimadas razões de prevalências a partir da regressão multivariada de Poisson. O percentual de mulheres na população alvo que relatou pelo menos um exame nos últimos três anos foi de 85,3%, com acentuada utilização do Sistema Único de Saúde (72,8%. Foram encontradas razões de prevalência estatisticamente significativas quanto à ausência do exame em mulheres de 18 a 24 anos, de 60 a 69 anos, solteiras, com menor renda e baixa escolaridade. As magnitudes encontradas nas razões de prevalência foram consistentes com achados de outros estudos, apontando maior necessidade de intervenção no grupo de mulheres mais vulneráveis à incidência e mortalidade por câncer do colo do útero.The objective of the study was to determine the self-reported prevalence of uterine cervical cancer testing in Rio Branco, Acre State, Brazil, and to analyze factors associated with non-participation in screening. A population-based cross-sectional study with a sample of 772 women 18 to 69 years of age and living in Rio Branco was conducted in 2007 and 2008. Data were analyzed with Stata 10.0, and prevalence rates were estimated with Poisson multivariate regression (95%CI. 85.3% of women reported at least one cervical cancer screening test in the previous three years. The majority of women (72.8% were screened in the Brazilian Unified National Health System. After adjusting for selected variables, statistically significant prevalence rates for absence of screening were found in women 18-24 and 60-69 years of age, single, and with low income and low schooling. The prevalence rates were consistent with findings from other studies, highlighting the need for greater intervention in the group of women most vulnerable to cervical cancer incidence and mortality.

  10. Correlation of human papilloma virus presence with precancerous and cancerous lesions of uterine cervix by immunohistochemistry

    Directory of Open Access Journals (Sweden)

    Meenu Pujani

    2012-01-01

    Full Text Available Background : Cancer of cervix is the most common form of cancer in females of developing countries. Cervical cancer is the best example of common human malignancy with a proven infectious etiology. The data linking human papilloma virus (HPV infection with the epidemiology and pathogenesis of cervical neoplasia is convincing. There are various methods for detection of HPV like immunohistochemistry, polymerase chain reaction, liquid phase hybridization (hybrid capture test, in situ hybridization etc. Materials and Methods: We studied the profile of precancerous and cancerous lesions of uterine cervix and correlated human papilloma virus (HPV presence with precancerous and cancerous lesions of uterine cervix by immunohistochemistry. Total 50 cases were first studied, analyzed, and classified histologically and then immunohistochemistry was done. Results : Majority of the cases 36/50 (72% under study are squamous cell carcinomas, which is the most common carcinoma found in the uterine cervix. HPV positivity for all cases of cervical carcinoma was found to be 34.7% (16/46 cases, for carcinoma in situ, it was 50% (2/4 cases. It can be thus hypothesized that with decreasing differentiation, there is loss of expression of HPV in the cervical epithelial cells. Conclusion: To conclude, though this study confirms the correlation of HPV presence with precancerous and cancerous lesions of uterine cervix, it also suggests that there must be other co-factors involved in cervical carcinogenesis as well.

  11. Neuroendocrine differentiation in a case of cervical cancer

    OpenAIRE

    Mona Mohamed Rashed; Alemayehu Bekele

    2010-01-01

    Neuroendocrine neoplasms may occur in the uterine cervix, although rarely; it accounts for 0.5-1% of all malignant tumors of the uterine cervix. A case report of an Ethiopian female presented at the Gynecology Out-Patient Clinic at Jimma University Hospital, complaining from irregular vaginal bleeding over the previous three months. Clinically there was a cauliflower cervical mass; histopathologically it was formed of sheets of small cell tumor; that further showed neuroendocrine differentiat...

  12. Adenocarcinoma of the Uterine Cervix

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Eun Ji; Shin, Hyun Soo; Lee, Hyung Sik; Kim, Gwi Eon; Loh, Juhn Kyu; Suh, Chang Ok [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    1991-12-15

    Survival data, prognostic factors, and patterns of failure were retrospectively analyzed for a total of 76 patients with adenocarcinoma of the uterine cervix treated between January 1981 and December 1987, which represents 4.1% of all primary cervical carcinomas treated, at Department of Radiation Oncology, Yensei Cancer Center, Yonsei University College of Medicine. The mean age of the patients was 49years(range, 27-79years) and the peak incidence was in the group 50 to 59years of age. More half of the patients were postmenopausal (46/76=60.5%). Most patients(76%)had abnormal vaginal bleeding either alone or in combination with other symptoms. The proportion of stage Iib was 43.4%. There were 4 major histologic subtypes: pure adenocarcinoma(48/76=63.2%), adenosquamous carcinoma(20/76=26.3%), papillary (5/76=6.6%) and clear cell carcinoma(3/76=3.9%). Of the many clinicopathologic variables evaluated for prognosis, the most significant prognostic factors were stage of disease and the size of tumor. The overall 5-year survival rate was 68%, and the 5-year survival rates for stage Ib, II and III were 90%, 66% and 54%, respectively. Control of pelvic tumors was achieved in 938%, 90.2% and 50.0% of cases of stage Ib, II and III disease, respectively. In present study, treatment modalities (radiation therapy alone/combined operative and radiation therapy) did not affect the local control of tumor and the survival.

  13. Acute puerperal uterine inversion

    International Nuclear Information System (INIS)

    Objective: To determine the frequency, causes, clinical presentations, management and maternal mortality associated with acute puerperal inversion of the uterus. Materials and Methods: All the patients who developed acute puerperal inversion of the uterus either in or outside the JPMC were included in the study. Patients of chronic uterine inversion were not included in the present study. Abdominal and vaginal examination was done to confirm and classify inversion into first, second or third degrees. Results: 57036 deliveries and 36 acute uterine inversions occurred during the study period, so the frequency of uterine inversion was 1 in 1584 deliveries. Mismanagement of third stage of labour was responsible for uterine inversion in 75% of patients. Majority of the patients presented with shock, either hypovolemic (69%) or neurogenic (13%) in origin. Manual replacement of the uterus under general anaesthesia with 2% halothane was successfully done in 35 patients (97.5%). Abdominal hysterectomy was done in only one patient. There were three maternal deaths due to inversion. Conclusion: Proper education and training regarding placental delivery, diagnosis and management of uterine inversion must be imparted to the maternity care providers especially to traditional birth attendants and family physicians to prevent this potentially life-threatening condition. (author)

  14. Pregnancy after uterine arterial embolization

    OpenAIRE

    Cláudio E. Bonduki; Paulo C. Feldner, Jr.; Juliana da Silva; Rodrigo A. Castro; Marair G. F. Sartori; Girão, Manoel J. B. C.

    2011-01-01

    OBJECTIVE: To evaluate pregnancy outcomes, complications and neonatal outcomes in women who had previously undergone uterine arterial embolization. METHODS: A retrospective study of 187 patients treated with uterine arterial embolization for symptomatic uterine fibroids between 2005-2008 was performed. Uterine arterial embolization was performed using polyvinyl alcohol particles (500-900 mm in diameter). Pregnancies were identified using screening questionnaires and the study database. RESULT...

  15. Modification of conservative treatment of heterotopic cervical pregnancy by Foley catheter balloon fixation with cerclage sutures at the level of the external cervical os: a case report

    OpenAIRE

    Vujisic Sanja; Ujevic Boris; Bauman Renato; Serman Alan; Ivkosic Ivana; Hafner Tomislav; Hafner Daria; Miskovic Berivoj

    2010-01-01

    Abstract Introduction Conservative treatment of a heterotopic cervical pregnancy was performed with a modification of the fixation of a Foley catheter at the level of the external cervical os, followed by the ligature of the descending cervical branches of the uterine arteries and systemic methotrexate application. Case presentation A 34-year-old Caucasian woman was diagnosed with double gestation after 6 weeks of in vitro fertilization treatment. A gynecological examination and color Doppler...

  16. Uterine mesenchymal tumors

    Directory of Open Access Journals (Sweden)

    Nikhil A Sangle

    2011-01-01

    Full Text Available Uterine mesenchymal tumors are a heterogeneous group of neoplasms that can frequently be diagnostically challenging. Differentiation between the benign and malignant counterparts of mesenchymal tumors is significant due to differences in clinical outcome, and the role of the surgical pathologist in making this distinction (especially in the difficult cases cannot be underestimated. Although immunohistochemical stains are supportive toward establishing a final diagnosis, the morphologic features trump all the other ancillary techniques for this group of neoplasms. This review therefore emphasizes the key morphologic features required to diagnose and distinguish uterine mesenchymal tumors from their mimics, with a brief description of the relevant immunohistochemical features.

  17. [Uterine sarcoma. Case report].

    Science.gov (United States)

    Mortara Gómez, Agueda Sofía; González Blanco, Rafael; Arias Loza, Rosa; Sangines Martínez, Augusto; Moreno Lara, Héctor José Manuel; Zertuche Zuani, José Gerardo

    2012-03-01

    55 years female patient who is sent to the New Hospital Durango management fibroids and anemia, why not start the study protocol for hysterectomy, preoperative presenting within normal parameters, transvaginal ultrasound uterine fibroids and endometrial hyperplasia, biopsy endometrium with endometrial hyperplasia without atypia simple, and is scheduled for total abdominal hysterectomy with bilateral salpingo-oophorectomy. Surgical procedure is performed with the incident of tearing the uterine body on the right side with extension to the neck and externalization of endometrial tissue, the event is completed without complications. Histopathologic endometrial stromal sarcoma of high grade. Management in a row by the oncology department by 25 sessions of radio and brachytherapy. PMID:22812179

  18. Dosimetric comparison of IMRT and modulated arc-therapy techniques in the treatment of cervical cancers; Comparaison dosimetrique des techniques de RCMI et d'arctherapie modulee dans le traitement des cancers du col uterin

    Energy Technology Data Exchange (ETDEWEB)

    Renard-Oldrini, S.; Charra-Brunaud, C.; Tournier-Rangeard, L.; Huger, S.; Marchesi, V.; Bouziz, D.; Peiffert, D. [Centre Alexis-Vautrin, Nancy (France)

    2011-10-15

    The authors report the dosimetric comparison of two techniques used for the treatment of cervical cancers: the intensity-modulated conformational radiotherapy (IMRT) with static beams and modulated arc-therapy with RapidArc. The treatment plans of 15 patients have been compared. The clinical target volume (CTV) comprises the gross target volume, the cervix, the upper third of the vagina, and ganglionary areas. The previsional target volume comprises the clinical target volume and a one centimetre margin. Organs at risk are rectum, bladder, intestine and bone marrow. Arc-therapy seems to provide a better sparing of intestine that IMRT, while maintaining a good coverage of the previsional target volume and decreasing treatment duration. Short communication

  19. RAPIDARC (RA) in the uterine cervical cancer; dosimetric gain vs 3D-Crt; RAPIDARC (RA) en el cancer de cervix uterino; ganancia dosimetrica vs 3D-CRT

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, J.; Garcia, B.; Quispe, K.; Gonzales, A.; Marquina, J., E-mail: jose.ramirez@aliada.com.pe [Clinica Aliada, Oncologia Integral, Av. Jose Galvez Barrenechea 1044, San Isidro, Lima (Peru)

    2014-08-15

    This work aims to quantitatively assess RAPIDARC (RA) treatments versus three dimensional-Conformal Radiation Therapy with field to field technique (3D-Crt-Fin F). 11 patients with cervical cancer treated at our institution radically or adjuvant clinical stages I-III B were evaluated. The prescribed dose was 50 Gy (2 Gy / Fr). The RA plans consisted of two isocentric complete arcs and conformational plans of 4 isocentric fields (previous, subsequent, right side and left side) with 3D-Crt-Fin F technique; both cases carried out ??in the Eclipse version 10 planner with calculation algorithm analytical anisotropic algorithm (AAA) and volumetric optimization software (for VMAT plans). Homogeneity indices (Hi), conformity indices (CI) Sigma indices (S-Index), monitor units (MU) and the time required for each treatment were compared. The mean age was 52 years (32-65) of the 11 patients 9 were clinical stages I-II B. The Hi varied from 0.052 for RA to 0.163 for 3D-Crt-Fin F (p = 0.009), and the CI between 1.005 and 1.35 (p = 0.26), the S-index from 1.2 to 3.7 (p = 0.001) and the H-index of 1.08 to 1.15 (p = 0.24). All dose limits in risk organs were met with a significant difference in the RA plans versus 3D-Crt-Fin F. In patients with cervical cancer the treatment plans quality with the indices aforementioned seems to be better with the RA technique, being observed a significant reduction of radiation to surrounding organs. (author)

  20. Cervical Cancer Prevention

    Science.gov (United States)

    ... Treatment Cervical Cancer Prevention Cervical Cancer Screening Research Cervical Cancer Prevention (PDQ®) What is prevention? Cancer prevention is ... to keep cancer from starting. General Information About Cervical Cancer Cervical cancer is a disease in which malignant ( ...

  1. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... to steer our way into the artery that supplies the uterus and supplies the fibroids. And we have a couple of ... very abnormal uterine artery, the very rich blood supply. And that is typical of a woman with ...

  2. Uterine Fibroid Embolization

    Science.gov (United States)

    ... looking at. Again, a typical pattern of a woman with symptomatic uterine fibroids. And we're going to go ahead and, as we did on the left side already, we're going to block it off on this side here. Jim, back you. All right, so Alex, maybe as we come back to ...

  3. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... looking at. Again, a typical pattern of a woman with symptomatic uterine fibroids. And we're going to go ahead and, as we did on the left side already, we're going to block it off on this side here. Jim, back you. All right, so Alex, maybe as we come back to ...

  4. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... to make sure that we're not going too fast, slowly inject, only going forward into the uterine artery. You're watching on your monitor the whole time, right Alex? And that's exactly right. I'm not watching my hands. My eyes are focused on the TV monitor that we, of course, ...

  5. A rare case of minimal deviation adenocarcinoma of the uterine cervix in a renal transplant recipient.

    LENUS (Irish Health Repository)

    Fanning, D M

    2009-02-03

    INTRODUCTION: We report the first described case of minimal deviation adenocarcinoma of the uterine cervix in the setting of a female renal cadaveric transplant recipient. MATERIALS AND METHODS: A retrospective review of this clinical case was performed. CONCLUSION: This rare cancer represents only about 1% of all cervical adenocarcinoma.

  6. A rare case of minimal deviation adenocarcinoma of the uterine cervix in a renal transplant recipient.

    LENUS (Irish Health Repository)

    Fanning, D M

    2012-02-01

    INTRODUCTION: We report the first described case of minimal deviation adenocarcinoma of the uterine cervix in the setting of a female renal cadaveric transplant recipient. MATERIALS AND METHODS: A retrospective review of this clinical case was performed. CONCLUSION: This rare cancer represents only about 1% of all cervical adenocarcinoma.

  7. Development of mixed mesodermal tumor after radiation therapy of uterine cervix

    International Nuclear Information System (INIS)

    A 69 years old female developed mixed mesodermal tumor of the uterine corpus, six years after radiotherapy of cervical cancer. The histology of the tumor was composed of adenocarcinoma and rhabdomyosarcoma. The cytology showed biphasic cellular pattern with cytoplasmic eosinophilic granules in sarcoma type cells. Causal relationship of the development of the tumor and the past radiationtherapy was suspected. (author)

  8. Conhecimento das mulheres sobre o câncer cérvico-uterino - DOI: 10.4025/actascihealthsci.v26i2.1582 Women’s knowledge of cervical uterine cancer - DOI: 10.4025/actascihealthsci.v26i2.1582

    Directory of Open Access Journals (Sweden)

    Maria Dalva de Barros Carvalho

    2004-04-01

    Full Text Available O objetivo deste estudo foi verificar o conhecimento que as mulheres têm sobre o exame preventivo do câncer cérvico-uterino, sua importância e os sentimentos delas em relação ao exame, em uma tentativa de melhor compreender a prática da prevenção. Trata-se de estudo descritivo exploratório. As mulheres demonstraram que, em relação ao exame, o medo e a vergonha são os maiores sentimentos. Em relação à importância do exame, a maioria relatou ser a prevenção e a descoberta precoce da doença o fator mais importante. Sobre o conhecimento da doença, relataram ter ouvido falar, visto na TV, mas o medo da doença e até do nome câncer é maior que a necessidade de realizar o exame.O que impede a realização do exame é o medo do resultado e a falta de tempo. Os dados permitiram concluir que é necessário aumentar a cobertura dos exames; orientar as mulheres através de campanhas e, ainda, desmistificar a técnica e os resultados dos mesmos.The aim of this work was to verify women’s knowledge of cervical uterine cancer prevention exam, its importance and women’s feelings towards it. This was done in order to better understand the prevention practice. This is an exploratory descriptive study. The women’s major feelings towards this exam are fear and shame. Regarding this exam importance, most of them said that the prevention and the precocious discovery of the illness are the most important factors. Knowledge of the disease was acquired through conversations and TV programs, even though fear of the disease is greater than the need to undertake the exams. The latter is impaired by fear regarding their result and by lack of time to undertake them. Data show that exam coverage should be broadened; more orientation should be given through campaigns; technique and exam results should be demystified.

  9. Evaluation of cervical cancer detection with acoustic radiation force impulse ultrasound imaging

    OpenAIRE

    SU, YIJIN; DU, LIANFANG; Wu, Ying,; ZHANG Juan; Zhang, XueMei; JIA, XIAO; CAI, YINGYU; LI, YUNHUA; Zhao, Jing; LIU, Qian

    2013-01-01

    The aim of this study was to evaluate the application of acoustic radiation force impulse (ARFI) ultrasound imaging and its potential value in the characterization of cervical cancer. ARFI ultrasound imaging of the uterine cervix was performed in 58 patients with cervical cancer prior to surgery. The diagnosis of cervical cancer was confirmed by pathological results in each case. eSie Touch elastography imaging (EI), Virtual Touch tissue imaging (VTI) and Virtual Touch tissue quantification (...

  10. Relationships between Mechanical Properties and Extracellular Matrix Constituents of the Cervical Stroma during Pregnancy

    OpenAIRE

    House, Michael; Kaplan, David L.; Socrate, Simona

    2009-01-01

    In normal pregnancy, the cervix maintains its shape during a period of substantial fetal and uterine growth. Hence, maintenance of biomechanical integrity is an important aspect of cervical function. It is known that cervical mechanical properties arise from the extracellular matrix. The most important constituent of the cervical extracellular matrix is fibrillar collagen – it is from collagen protein that the cervix derives its “strength.” Other matrix molecules known to affect the collagen ...

  11. The impact of Human papilloma virus (HPV) infection on the development of cervical neoplasia

    OpenAIRE

    Vlad Gheorghita; Cornelia Amalinei; Ovidu Toma; Raluca Balan; Irina Draga Cruntu

    2008-01-01

    The genesis of uterine cervix carcinoma has as central etiology the active infection of human papilloma virus (HPV), especially high oncogenic risk subtypes. However, this is a necessary, but not sufficient cause of virtually all cases of cervical cancer worldwide. At present, the proportion of cervical carcinomas attributed to HPV infection is estimated at 99%. It is considered that the pathogenesis of cervical carcinoma is the result of the proliferation of one or, at most, a few HPV-infect...

  12. Hysteroscopic Resection of Cervical Nerve Sheath Tumor

    OpenAIRE

    Goldfarb, Robert S; Davidson, Brent N.

    1999-01-01

    Isolated nerve sheath tumors of the uterine cervix are very rare entities. This is especially true for benign nerve sheath tumors. We present, to the best of our knowledge, the first case of a benign nerve sheath tumor resected hysteroscopically. Our patient is a 69 year-old white female with a history of post menopausal bleeding. Initial workup included an endometrial biopsy and an ultrasound. A 4 cm cervical mass was identified on that study.

  13. Erosive gastritis

    International Nuclear Information System (INIS)

    Erosive gastritis is a well-defined radiologic and endoscopic entity. It is one of the common causes of upper gastrointestinal bleeding, yet it is seldom diagnosed and often confused with a number of other diseases. This communication re-emphasizes the characteristic endoscopic and radiologic features of erosive gastritis and its differential diagnosis. Two representative cases are reported. (orig.)

  14. Cervical Cancer

    Science.gov (United States)

    ... cervical cancer: • Smoking. • Having HIV (the virus that causes AIDS) or another condition that makes it hard for your body to fight off health problems. • Using birth control pills for a ... It protects against the types of HPV that most often cause cervical, vaginal, and vulvar cancers. It is given ...

  15. Cervical Cap

    Science.gov (United States)

    ... this tool to play your goals. Hot Topics Stress & Coping Center Writing a Paper Abusive Relationships Dynamic Stretching A Guy's Guide to Body Image Cervical Cap KidsHealth > Teens > Sexual Health > Birth Control > Cervical Cap Print A A A Text ...

  16. Uterine fibroid vascularization and clinical relevance to uterine fibroid embolization.

    Science.gov (United States)

    Pelage, Jean-Pierre; Cazejust, Julien; Pluot, Etienne; Le Dref, Olivier; Laurent, Alexandre; Spies, James B; Chagnon, Sophie; Lacombe, Pascal

    2005-10-01

    Embolization has become a first-line treatment for symptomatic uterine fibroid tumors. Selective catheterization and embolization of both uterine arteries, which are the predominant source of blood flow to fibroid tumors in most cases, is the cornerstone of treatment. Although embolization for treatment of uterine fibroid tumors is widely accepted, great familiarity with the normal and variant pelvic arterial anatomy is needed to ensure the safety and success of the procedure. The uterine artery classically arises as a first or second branch of the anterior division of the internal iliac artery and is usually dilated in the presence of a uterine fibroid tumor. Angiography is used for comprehensive pretreatment assessment of the pelvic arterial anatomy; for noninvasive evaluation, Doppler ultrasonography, contrast material-enhanced magnetic resonance (MR) imaging, and MR angiography also may be used. After the uterine artery is identified, selective catheterization should be performed distal to its cervicovaginal branch. For targeted embolization of the perifibroid arterial plexus, injection of particles with diameters larger than 500 mum is generally recommended. Excessive embolization may injure normal myometrium, ovaries, or fallopian tubes and lead to uterine necrosis or infection or to ovarian failure. Incomplete treatment or additional blood supply to the tumor (eg, via an ovarian artery) may result in clinical failure. The common postembolization angiographic end point is occlusion of the uterine arterial branches to the fibroid tumor while antegrade flow is maintained in the main uterine artery. PMID:16227501

  17. Incidencia y tendencia de lesiones cervicouterinas en mujeres pinareñas de 10-24 años. 2003-2012 / Incidence and tendency of cervical-uterine lesions in Pinar del Río 10-to-14-year-old women, 2003-2012

    Scientific Electronic Library Online (English)

    José Guillermo, Sanabria Negrín; Victor Enrique, Salgueiro Medina; Magalys Brígida, Abreu Mérida; Agustín, Lemus Sarracino; Raydel, Marrero Fernández.

    2014-02-01

    Full Text Available Introducción: se han detectado lesiones premalignas y malignas en mujeres menores de 25 años, pero no se conoce exactamente la magnitud del problema en Pinar del Río. Objetivo: evaluar la incidencia y la tendencia de lesiones premalignas y malignas del cuello uterino en mujeres pinareñas menores de [...] 25 años según características demográficas en el período 2003-2012. Material y método: se realizó un estudio retrospectivo, longitudinal para conocer la incidencia anual de lesiones premalignas y malignas del cuello uterino en mujeres pinareñas menores de 25 años. La muestra estuvo conformada por el resultado de las biopsias realizadas a estas jóvenes en ese período. Resultados: la incidencia anual por 10000 mujeres 10-24 años fue de 8.8 para las NIC I; 3,1 en NIC II; 1,6 para las NIC III + CIS, 0.07 para el microinvasor, 0.03 para el invasor Ib y 0.02 para el invasor estadio II. No se detectaron ni estadios superiores de la variedad epidermoide y adenocarcinomas endocervicales. La incidencia anual para cada una de las lesiones mostró una tendencia al incremento sobre todo para las NIC I. De 1198 biopsias realizadas en este grupo etario solamente se detectaron 7 carcinomas epidermoides invasores cervicales en 10 años, 0.7 anuales, con tasa de 5.8 x cada 1000 mujeres de 10-24 años. Conclusiones: la incidencia detectada de lesiones malignas en este grupo no justificaría comenzar la realización del pesquisaje citológico antes de los 25 años, ya que el costo sería alto y el beneficio mínimo. Abstract in english Introduction: malignant and pre-malignant lesions have been localized in women less than 25 years, but the exact enormity of the problem in Pinar del Río is not known. Objective: to evaluate the tendency and incidence of malignant and pre-malign cervical lesions in Pinar women less than 25 years old [...] according to demographic characteristics, in the period 2003-2012. Material and method: a retrospective, cross-sectional study was carried out, in order to know the annual incidence of malign and pre-malign cervical lesions in Pinar women younger than 25 years. The sample comprised the results of biopsies made of those women in that period. Results: the annual incidence in 10,000 women from 10-24 years old was 8.8 for CIN1, 3.1 for CIN2, 1.6 for CIN3 + CIS (carcinoma in situ), 0.07 for de micro-invasive, 0.03 for the invasive Ib, and 0.02 for the invasive stage II. Stages over neither epidermoidal nor endocervical adenocarcinomas were detected. The annual incidence in each lesion proved increasing particularly for NIC1 cases. Out of 1,198 biopsies made on this age group, only 10 invasive epidermoidal carcinomas were detected in ten years, 0.7 annually, with a proportion of 5.8 per 1,000 women between 10-24 years of age. Conclusions: The tendency of malignant lesions detected in this group would not justify starting the cytological screening before the 25 years of age, since the cost would high and the benefit would be minimal.

  18. Radiologic diagnosis and treatment of iatrogenic acquired uterine arteriovenous malformation

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Jung Hyeok [College of Medicine, Keimyung Univ., Taegu (Korea, Republic of)

    2002-05-01

    To analyze gray-scale US, color and duplex Doppler US, and angiographic findings in patients with acquired uterine arteriovenous malformations (AVMs), and to evaluate the usefulness of these modalities in the diagnosis of this disease and the effect of transcatheter arterial embolization in its treatment. During a recent seven-year period, we diagnosed 21 cases of acquired uterine AVM. Nineteen of these patients had a history of causative D and C (between one and seven D and C procedures per patient), one had a history of causative cesarean section, and one had cervical conization. All patients underwent transabdominal and endovaginal gray-scale, color Doppler, and duplex Doppler US and angiography, with therapeutic embolization of bilateral uterine arteries. The majority underwent follow-up Doppler US after embolization. The gray-scale US morphology of uterine AVMs included subtle myometrial inhomogeneity and multiple distinct, small anechoic spaces in the thickened myometrium or endometrium. Color Doppler US showed a tangle of tortuous vessels with multidirectional, high-velocity arterial flow, which was focally or asymmetrically distributed. Duplex Doppler US depicted a waveform of fast arterial flow with low resistance, while angiography demonstrated a complex tangle of vessels supplied by enlarged uterine arteries, in association with early venous drainage during the arterial phase, and staiss of contrast medium within abnormal vasculature. Where AVMs were combined with a pseudoaneurysm, this finding was observed. Transcatheter arterial embolization provided a complete cure, without recurrence. Color and duplex Doppler US in an appropriate modality for the detection and diagnosis of uterine AVMs and for follow-up after embolization. Transcatheter arterial embolization is a safe and effective method of treating this disease.

  19. Cervical thymoma

    Scientific Electronic Library Online (English)

    Abrão, Rapoport; Claudiane Ferreira, Dias; João Paulo Aché de, Freitas; Ricardo Pires de, Souza.

    1999-05-06

    Full Text Available CONTEXTO: O timoma cervical é neoplasia primitiva do timo. Sua incidência é muito rara. Esta doença apresenta maior incidência em pacientes do sexo feminino, entre a quarta e sexta décadas. RELATO DE CASO: Apresentamos o caso de uma paciente do sexo feminino, 54 anos, com timoma cervical. Durante o [...] período de dois anos e meio de investigação teve evolução assintomática com crescimento progressivo do nódulo cervical, próximo à tireóide. A paciente não apresentou alterações dos exames de função tireoidiana ou dos exames subsidiários realizados. O diagnóstico de timoma cervical foi realizado no intra-operatório sendo conclusivo com o estudo anatomopatológico da peça retirada. O timoma cervical é raro, com difícil diagnóstico pré-operatório. Atualmente utiliza-se métodos complementares para o diagnóstico preciso como: a cintilografia com Tálio 201, o Tecnésio 99 e o Iodo 131, além da ressonância nuclear magnética e, principalmente, realizando o estudo e classificação histopatológica. Abstract in english CONTEXT: Cervical thymoma is a primitive thymic neoplasia. It is very rare. This disease presents higher incidence in female patients in their 4th to 6th decade of life. We present a case report of a cervical thymoma CASE REPORT: 54-year-old female patient, caucasian, with no history of morbidity, p [...] resenting a left cervical nodule close to the thyroid gland. During the 30 months of investigation a left cervical nodule grew progressively next to the thyroid while the patient showed no symptoms, making accurate diagnosis difficult. Tests on her thyroid function did not show changes, nor were there changes in any subsidiary tests. The diagnosis of the disease was made intra-operatively through total thyroid individualization. The results were confirmed by the histological findings from the ressected material. Cervical thymoma is a very rare disease, with difficult preoperatory diagnosis. Some additional study methods which are employed today are thallium 201, technetium 99 and iodine 131 scintigraphy, magnetic nuclear resonance and especially histopathological findings and classification.

  20. Staging of carcinoma of the uterine cervix and endometrium

    Energy Technology Data Exchange (ETDEWEB)

    Koyama, Takashi; Tamai, Ken; Togashi, Kaori [Kyoto University, Department of Diagnostic Radiology, Graduate School of Medicine, Kyoto (Japan)

    2007-08-15

    Carcinoma of the uterine cervix and endometrium are common gynecologic malignancies. Both carcinomas are staged and managed by means of the International Federation of Gynecology and Obstetrics (FIGO) staging system. In uterine cervical cancer, the FIGO staging system is determined preoperatively by limited conventional procedures. Although this system is effective for early stage disease, it has inherent inaccuracies in advanced stage diseases and does not address nodal involvement. CT and MR imaging are widely used as comprehensive imaging modalities to evaluate tumor size and extent, and nodal involvement. MR imaging is an excellent modality for depicting invasive cervical carcinoma and can provide objective measurement of tumor volume, and provides high negative predictive value for parametrial invasion and stage IVA disease. In contrast, endometrial cancer is surgically staged. Beside recognition of the important prognostic factors, including histologic subtype and grade, accurate assessment of the tumor extent on preoperative MR imaging is expected to greatly optimize surgical procedure and therapeutic strategy. Contrast-enhanced MR imaging can offer ''one stop'' examination for evaluating the depth of myometrial invasion cervical invasion and nodal metastases. Evaluation of myometrial invasion on MR imaging may be an alternative to gross inspection of the uterus during the surgery. (orig.)

  1. Clinical assessment of uterine endometrial cancer by magnetic resonance imaging

    International Nuclear Information System (INIS)

    A retrospective review of magnetic resonance (MR) images of 33 patients with surgically proved uterine endometrial cancer was done to define the essential sequence of MR imaging for the purpose of shortening of the scan time. Only T2 weighted sagittal image was studied for cancer staging. The relation between surgical staging and the ratio of tumor width to uterine width in the sagittal plane as well as direct image analysis was evaluated. The cervical involvement was diagnosed by continuity of tumor intensity into cervical canal, adnexal invasion by swelling of adnexa, myometrial invasion by blurring of tumor-myometrial interface. Accuracy of direct MR imaging analysis as for cervical involvement, adnexal invasion, and myometrial invasion were 83.3%, 77.8%, 73.3% respectively. The tumor volume ratio showed a statistically significant difference (p<0.05) between cases with superficial myometrial invasion and with deep invasion, while there was no difference between cases without myometrial invasion and those with superficial invasion. Thus we suggest that when tumor volume ratio was over 75% one must consider the possibility of deep myometrial invasion even if the tumor-myometrial interface was smooth. (author)

  2. Erhversbetinget erosion?

    DEFF Research Database (Denmark)

    Dige, Irene; Gjørup, Hans; Nyvad, Bente

    2012-01-01

    Baggrund – I forbindelse med dental erosion er en grundig udredning af patienten vigtig, således at årsagen til erosionernes opståen findes, og der kan iværksættes adækvat forebyggende indsats. En sådan udredning er ikke mindst vigtig, når arbejdsmiljøet mistænkes. Patienttilfælde – En 30-årig pa...... arbejdsskade, men ikke anerkendt, da erosioner ikke er optaget på Arbejdsskadestyrelsens liste over erhvervssygdomme. En systematisk registrering af lignende tilfælde kunne imidlertid på sigt ændre retspraksis for fremtidige patienter med arbejdsbetinget erosion.......Baggrund – I forbindelse med dental erosion er en grundig udredning af patienten vigtig, således at årsagen til erosionernes opståen findes, og der kan iværksættes adækvat forebyggende indsats. En sådan udredning er ikke mindst vigtig, når arbejdsmiljøet mistænkes. Patienttilfælde – En 30-årig...... patient, der arbejder som pladesmed, blev henvist til Landsdels- og Videnscenter, Århus Sygehus, med henblik på udredning af patientens kraftige slid. Patienten udviste ikke-alderssvarende tandslid af emalje og dentin svarende til erosion forårsaget af syredampe i arbejdsmiljøet, muligvis forstærket af...

  3. Can we rely on cancer mortality data? Checking the validity of cervical cancer mortality data for Slovenia

    International Nuclear Information System (INIS)

    Background. Valid inference on cervical cancer mortality is very difficult since - on the basis of death certificates - it is not always possible to distinguish between cervix, corpus and unspecified uterine cancer deaths. Our aim was to estimate the extent to which cervical cancer as the official cause of death reflects the true mortality from cervical cancer in Slovenia. Material and methods. The data on 2245 deaths from cervix, corpus uteri, and uterus-unspecified cancers for the period 1985-1999 were linked to the Cancer Registry of Slovenia database from the mortality database of Slovenia. Results. Officially, in the period 1985-1999, there were 878 cervical cancer deaths. The comparison of these causes of death with the cancer sites registered in the Cancer Registry revealed that they include only 87.7% patients with a previous diagnosis of cervical cancer. Of 650 corpus uteri cancer deaths, 17. 1 % of patients were registered to have cervical cancer, and of 717 unspecified uterine cancer deaths, 31.4% were registered. Taking into account the correctly identified cervical cancer cases among cervical cancer deaths and misclassified cervical cancer deaths as corpus uteri and unspecified uterine, the corrected number of deaths would be 1106. Conclusions. When evaluating the impact of cervical cancer mortality from national mortality rates, the stated underestimation should be taken into account. However, this does not hold for some other cancers. (author)

  4. Molecular detection of human papillomavirus in 594 uterine cervix samples from moroccan women, 147 biopsies and 447 swabs

    OpenAIRE

    Amrani, M.; Lalaoui, K.; El Mzibri, M.; Lazo, Pedro A; Belabbas, M.A.

    2003-01-01

    Uterine cervix cancer is the second most frequent female cancer after breast cancer in Morocco and represents a public health problem. Cervical cancer is highly linked to human papillomavirus (HPV) especially types 16 and 18 which are the highly oncogenic genotypes. To identify the contribution of HPV testing in the prevention of cervical cancer in Morocco, 147 biopsies collected at the Institut National d’Oncologie and 447 swabs from pathology laboratories and gynaecologist offic...

  5. Small Cell Carcinoma of the Uterine Cervix in a Pregnant Patient Diagnosed with Liquid Based Cytology and Cell Block Immunocytochemistry

    OpenAIRE

    Mawuli F. Attipoe; Charles D. Sturgis

    2014-01-01

    Definitive cytomorphologic diagnosis of small cell carcinoma of the uterine cervix is possible but can be challenging in routine cervicovaginal cancer screening specimens. Several small series of reported cases of cervical small cell carcinoma have shown this uncommon malignancy to represent fewer than 2% of all invasive cervical cancers. This tumor type is associated with poor prognosis and rapid disease progression and can develop to an advanced stage in the interval between screening visit...

  6. Cervical Stenosis

    Science.gov (United States)

    ... abnormalities, such as no periods (amenorrhea), painful periods (dysmenorrhea), and abnormal bleeding. Cervical stenosis can also cause ... cause symptoms. A hematometra or pyometra can cause pain or cause the uterus to ... (menstrual periods have stopped). They have no symptoms and ...

  7. Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women

    OpenAIRE

    Vidal Adriana C; Murphy Susan K; Hernandez Brenda Y; Vasquez Brandi; Bartlett John A; Oneko Olola; Mlay Pendo; Obure Joseph; Overcash Francine; Smith Jennifer S; van der Kolk Mike; Hoyo Cathrine

    2011-01-01

    Abstract Background Infection with human papillomavirus (HPV) is associated with uterine cervical intraepithelial neoplasia (CIN) and invasive cancers (ICC). Approximately 80% of ICC cases are diagnosed in under-developed countries. Vaccine development relies on knowledge of HPV genotypes characteristic of LSIL, HSIL and cancer; however, these genotypes remain poorly characterized in many African countries. To contribute to the characterization of HPV genotypes in Northeastern Tanzania, we re...

  8. Lajjalu treatment of uterine prolapse

    OpenAIRE

    Shivanandaiah, T. M.; Indudhar, T. M.

    2010-01-01

    Mimosa pudica was found useful in cases of uterine prolapse with bleeding, consistent with my experience of working with the condition for more than 45 years, and treating hundreds of such cases of uterine prolapse. Hysterectomy has been avoided up to this date, and is not now expected to be recommended.

  9. PET in uterine malignancies

    OpenAIRE

    Valeria Pirro; Andrea Skanjeti; Ettore Pelosi

    2010-01-01

    Positron Emission Tomography (PET) or integrated PET/Computed Tomography (PET/CT) with 18F-Fluoro-Deoxy-Glucose (18F-FDG) is a functional imaging modality, useful in the characterization of undetermined morphological findings, and in the staging/re-staging of a large number of malignancies. Although its use in uterine malignancies has been poorly investigated, in recent years the employment of this technique has constantly increased. In this review, we evaluate the role of PET (/CT) with 18FF...

  10. Integralidade na assistência à mulher na prevenção do câncer cérvico-uterino: um estudo de caso / Integrality in women's health in the prevention of cervical-uterine cancer: a case study / Integralidad en la atención a la mujer en la prevención del cáncer de cuello uterino: un estudio de caso

    Scientific Electronic Library Online (English)

    Francisco Rosemiro Guimarães, Ximenes Neto; Isabel Cristina Kowal Olm, Cunha.

    2006-09-01

    Full Text Available Realizou-se análise da gestão da atenção, com base na integralidade da assistência à saúde da mulher na prevenção do câncer cérvico-uterino, através de entrevista com duas pacientes atendidas em serviço de saúde da região nordeste do país. Consistiu num estudo de caso onde os dados foram analisados [...] através do Fluxograma Analisador do Modelo de Atenção de um Serviço de Saúde. Em um caso identificou-se a integração dos pontos de atenção, com caráter integral e no outro a fragmentação total desta. No estudo é percebida a importância de maior atenção do gestor no sentido de melhor planejar, organizar e avaliar as ações nos serviços de atenção saúde da mulher, buscando a eficiência, a eficácia e a efetividade, assegurando que os princípios do Sistema Único de Saúde sejam respeitados. Abstract in spanish Este estudio tuvo como objetivo analizar la gerencia de la atención basado en la integralidad de salud de la mujer en la prevención del cáncer de cuello uterino, usando la entrevista con dos pacientes atendidas en un servicio de salud en la región nordeste brasileña. Se constituye en un estudio caso [...] cuyos datos fueron analizados según el Fluxograma Analizador del Modelo de Atención de un servicio de Salud. En uno de los casos se identificó la integración de los puntos de atención; de tipo integral y, en el otro, la fragmentación total de estos. Se percibe en el estudio la importancia de la mayor atención del gerenciador para poder planear mejor, organizar y evaluar las acciones en los servicios de la salud de las mujeres, en la busqueda de los parámetros de la eficiencia, eficacia y efetividad, garantizando que los principios del Sistema Único de Salud sean cumplidos y respetados. Abstract in english This study aimed at analysing attention-based management based upon women's health integration in the prevention of cervical-uterine cancer, using interviews with two patients who were given care in a healthcare service in the northeast region of Brazil. In this case study the data was analysed acco [...] rding to the Analysis Fluxogram of the Healthcare Attention Model. In one of the cases total integration of attention scores was identified; while in the other total fragmentation of attention scores was identified. In this study the relevance of greatest attention was played by the manager in the sense of better planning, organization, and evaluation of the service's interventions in women's healthcare; services that sought efficiency, and effectiveness, assuring that the principles of the Brazilian National Health Care System are respected.

  11. Educação em saúde para prevenção do câncer de colo do útero em mulheres do município de Santo Ângelo/RS Education in health for prevention of uterine cervical cancer in women in Santo Ângelo, state of Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Micheli Renata Casarin

    2011-09-01

    Full Text Available No Brasil, o câncer cérvico-uterino constitui importante problema de saúde, pois apresenta alto índice de letalidade entre mulheres de varias idades. O exame citopatológico foi preconizado como medida de prevenção deste tipo de câncer, devendo ser realizado a partir do início da vida sexual. O estudo teve um caráter prático de promover educação em saúde sexual e conhecer o perfil da saúde sexual de mulheres de Santo Ângelo/RS. As palestras abordaram formas de prevenção e identificação de possíveis sintomas da doença. O levantamento do perfil de saúde sexual das participantes foi realizado através da aplicação de um questionário estruturado. Participaram das palestras 140 mulheres com idades entre 15 e 60 anos. Verificou-se que, mesmo enfrentando dificuldades e medo, a maioria delas realiza exame preventivo, motivada por aparecimento de sintomas e pelo hábito de cuidar da saúde. As participantes referiram a importância da integração entre profissionais e educadores em Saúde. O estudo foi direcionado no sentido de dar relevância à promoção da saúde e à prevenção do câncer, buscando evitar a doença e obter melhores condições de vida para as mulheres.In Brazil, cervical uterine cancer is a major public health problem as it has high mortality rate indices among women of different ages. A cytopathological examination is recommended for preventing this type of cancer from the early stages of a woman's reproductive life. The scope of this study was both to give talks on sexual health education and establish the sexual health profile of women from St. Angelo/RS. The lectures included measures for prevention as well as identification of possible symptoms of the disease. The research into the sexual health profile of the participants was conducted by a structured questionnaire applied to 140 women aged between 15 and 60. It was found that even experiencing difficulties and apprehension, the majority of the women performed the preventive examination. The motivation for taking the exam is the appearance of symptoms and the habit of caring for their health. The participants mentioned the importance of health professionals and educators working together. The study sought to promote health and cancer prevention, seeking to avoid the disease and ensure better living conditions for women.

  12. [The role of biogenic amines in the mechanism of uterine hemorrhage in uterine myoma].

    Science.gov (United States)

    Bel'skaia, G D

    1990-02-01

    Function of the adrenosympathetic system has been assessed in 103 patients with uterine myoma. Levels of biogenic amines (adrenaline, noradrenaline, histamin) were determined in uterine tissues using spectrofluorometry. It was found out that storage of vasoactive mediators in the uterine tissue represents a mechanism of uterine bleedings in patients with uterine myoma. Another determinant is stress experienced by patients with menometrorrhagia. PMID:2339756

  13. Get Tested for Cervical Cancer

    Science.gov (United States)

    ... Print This Topic En español Get Tested for Cervical Cancer Browse Sections The Basics Overview Cervical Cancer Pap ... Cervical Cancer 1 of 7 sections The Basics: Cervical Cancer What is cervical cancer? Cervical cancer is cancer ...

  14. MR features of isolated uterine relapse in an adolescent with acute lymphoblastic leukaemia

    Energy Technology Data Exchange (ETDEWEB)

    Novellas, Sebastien; Fournol, Maude; Geoffray, Anne; Chevallier, Patrick [Regional Hospital Centre and University of Nice, Medical Imaging Service, Archet 2 Hospital, 151 route de Saint Antoine de Ginestiere, B.P. 3079, Nice Cedex 3 (France); Deville, Anne [Regional Hospital Centre and University of Nice, Paediatric Service, Archet 2 Hospital, Nice (France); Kurzenne, Jean-Yves [Regional Hospital Centre and University of Nice, Paediatric Surgery Service, Archet 2 Hospital, Nice (France)

    2008-03-15

    Relapses of lymphoblastic leukaemia traditionally involve the central nervous system and testes in boys. Involvement of the female pelvic organs is frequently found at autopsy; however, involvement of the cervical uterus is rare and even less commonly symptomatic. A 13-cm uterine mass was discovered in a 15-year-old adolescent with a history of lymphoblastic leukaemia during childhood. Pelvic MRI was the best tool to assess the size, characteristics and invasive nature of this lesion of the uterine cervix. To our knowledge, this is a unique case in that we describe the MRI appearance of a relapsing lymphoblastic leukaemic mass both before and after treatment. (orig.)

  15. MR features of isolated uterine relapse in an adolescent with acute lymphoblastic leukaemia

    International Nuclear Information System (INIS)

    Relapses of lymphoblastic leukaemia traditionally involve the central nervous system and testes in boys. Involvement of the female pelvic organs is frequently found at autopsy; however, involvement of the cervical uterus is rare and even less commonly symptomatic. A 13-cm uterine mass was discovered in a 15-year-old adolescent with a history of lymphoblastic leukaemia during childhood. Pelvic MRI was the best tool to assess the size, characteristics and invasive nature of this lesion of the uterine cervix. To our knowledge, this is a unique case in that we describe the MRI appearance of a relapsing lymphoblastic leukaemic mass both before and after treatment. (orig.)

  16. Comparison of MR imaging and CT in the evaluation of uterine tumors

    International Nuclear Information System (INIS)

    The authors compared the usefulness of MR imaging and CT in staging uterine tumors. Forty women with known cervical carcinoma, endometrial cancer, or leiomyosarcoma underwent CT and MR imaging within 1 week prior to surgery. MR imaging was better than CT for localizing tumors to the endometrium of myometrium and in the evaluation of lymph node involvement and extension to the cervix and parametria. MR imaging, with its superior ability to demonstrate pelvic anatomy and its lack of ionizing radiation and risk from iodinated contrast media, has an important place in the staging of uterine tumors

  17. Uterine neoplasms, version 1.2014.

    Science.gov (United States)

    Koh, Wui-Jin; Greer, Benjamin E; Abu-Rustum, Nadeem R; Apte, Sachin M; Campos, Susana M; Chan, John; Cho, Kathleen R; Cohn, David; Crispens, Marta Ann; Dupont, Nefertiti; Eifel, Patricia J; Fader, Amanda Nickles; Fisher, Christine M; Gaffney, David K; George, Suzanne; Han, Ernest; Huh, Warner K; Lurain, John R; Martin, Lainie; Mutch, David; Remmenga, Steven W; Reynolds, R Kevin; Small, William; Teng, Nelson; Tillmanns, Todd; Valea, Fidel A; McMillian, Nicole; Hughes, Miranda

    2014-02-01

    Adenocarcinoma of the endometrium (also known as endometrial cancer or more broadly as uterine cancer or carcinoma of the uterine corpus) is the most common malignancy of the female genital tract in the United States. An estimated 49,560 new uterine cancer cases will occur in 2013, with 8190 deaths resulting from the disease. Uterine sarcomas (stromal/mesenchymal tumors) are uncommon malignancies, accounting for approximately 3% of all uterine cancers. The NCCN Guidelines for Uterine Neoplasms describe malignant epithelial carcinomas and uterine sarcomas; each of these major categories contains specific histologic groups that require different management. This excerpt of these guidelines focuses on early-stage disease. PMID:24586086

  18. Evidence for benefits from treating cervical ectopy: literature review / Evidências de benefícios no tratamento de ectopia do colo do útero: revisão de literatura

    Scientific Electronic Library Online (English)

    Luís Carlos, Machado Junior; Ana Sílvia Whitaker, Dalmaso; Heráclito Barbosa de, Carvalho.

    2008-03-01

    Full Text Available CONTEXTO E OBJETIVO: A ectopia do colo do útero é hoje considerada um fenômeno fisiológico, mas parece ainda haver uma forte tendência no sentido da intervenção (tratamento). Este estudo se propõe a realizar revisão da literatura buscando evidências de benefícios conseqüentes ao tratamento da ectopi [...] a. MÉTODOS: Pesquisa nas bases Medical Literature Analysis and Retrieval Sysem Online (Medline), Excerpta Medica Database (Embase), Literatura Latino-Americane e do Caribe em Ciências da Saúde (Lilacs), Biblioteca Cochrane e seis livros especializados. RESULTADOS: A revisão mostrou que: 1) existe provavelmente associação de ectopia com infecção cervical por Chlamydia trachomatis, pelo vírus HPV e maior risco de soroconversão para HIV; 2) existe provavelmente associação entre ectopia e neoplasia intra-epitelial cervical; 3) existe associação com mucorréia e nictúria; 4) não existem evidências sobre associação entre ectopia e câncer de colo do útero nem sobre proteção contra este câncer proporcionada pelo tratamento da ectopia. CONCLUSÕES: 1) Não foram encontrados na literatura dados que justifiquem o tratamento rotineiro da ectopia; 2) O tratamento pode ser utilizado para tratar sintomas associados à ectopia, porém mais sintomas são atribuídos à ectopia do que se pôde confirmar em um estudo controlado; 3) Seriam necessários novos estudos para testar a hipótese de proteção contra o câncer de colo proporcionada pelo tratamento. Abstract in english CONTEXT AND PURPOSE: Uterine cervical ectopy (cervical erosion) is today considered to be a physiological condition, but there still seems to be a strong tendency towards treating it. The purpose of this study was to review the medical literature for evidence regarding benefits from treating cervica [...] l ectopy. METHODS: The following databases were reviewed: Medical Literature Analysis and Retrieval System Online (Medline), Excerpta Medica Database (Embase), Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) and Cochrane Library databases. In addition, six medical textbooks were consulted. RESULTS: The review showed that: 1) there is probably an association between ectopy and higher risk of Chlamydia trachomatis, human papillomavirus and human immunodeficiency virus infection; 4) there is probably an association between ectopy and cervical intraepithelial neoplasia; 5) there is an association between ectopy and mucous discharge and nocturia; and 6) there is no evidence of an association between ectopy and cervical cancer, or of protection against cervical cancer associated with ectopy treatment. CONCLUSIONS: 1) No data were found in the medical literature to support routine treatment for ectopy; 2) Treatment could be recommended for symptom relief, but more symptoms are attributed to ectopy than could be demonstrated in a controlled study; 3) Further studies to test the hypothesis of protection against cervical cancer associated with treatment are necessary.

  19. Cervical Cancer – A Review Article

    Directory of Open Access Journals (Sweden)

    Gunjan Jadon

    2012-07-01

    Full Text Available Cervical Cancer is malignant Carcinoma type of cancer originate in cervix region. The cervix is the narrow portion of the uterus where it joins with the top of the vagina. Most cervical cancers are squamous cell carcinomas, arising in the squamous (flattened epithelial cells that line the cervix. Adenocarcinoma, arising in glandular epithelial cells is the second most common type. Very rarely, cancer can arise in other types of cells in the cervix. Cancer refers to a class of diseases in which a cell or a group of cells divide and replicate uncontrollably, intrude into adjacent cells and tissues (invasion and ultimately spread to other parts of the body than the location at which they arose (metastasis (National Cancer Institute 2009. In cervical cancer, (cancer of the uterine cervix, cancer develops in the tissues of the cervix, which is a part of the female reproductive system. The cervix connects the upper body of the uterus to the vagina. The endocervix (the upper part which is close to the uterus is covered by glandular cells, and the ectocervix (the lower part which is close to the vagina is covered by squamous cells. The transformation zone refers to the place where these two regions of the cervix meet (American Cancer Society 2009.

  20. Cervical cancer.

    Science.gov (United States)

    Koh, Wui-Jin; Greer, Benjamin E; Abu-Rustum, Nadeem R; Apte, Sachin M; Campos, Susana M; Chan, John; Cho, Kathleen R; Cohn, David; Crispens, Marta Ann; DuPont, Nefertiti; Eifel, Patricia J; Gaffney, David K; Giuntoli, Robert L; Han, Ernest; Huh, Warner K; Lurain, John R; Martin, Lainie; Morgan, Mark A; Mutch, David; Remmenga, Steven W; Reynolds, R Kevin; Small, William; Teng, Nelson; Tillmanns, Todd; Valea, Fidel A; McMillian, Nicole R; Hughes, Miranda

    2013-03-01

    These NCCN Clinical Practice Guidelines in Oncology for Cervical Cancer focus on early-stage disease, because it occurs more frequently in the United States. After careful clinical evaluation and staging, the primary treatment of early-stage cervical cancer is either surgery or radiotherapy. These guidelines include fertility-sparing and non-fertility-sparing treatment for those with early-stage disease, which is disease confined to the uterus. A new fertility-sparing algorithm was added for select patients with stage IA and IB1 disease.. PMID:23486458

  1. Uterine arterial embolization for uterine leiomyoma: efficacy and clinical outcome

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jeong Seon; Lee, Do Yon; Kim, Yong Tae; Park, Ki Hyun; Park, Yong Won; Cho, Jae Sung; Kim, Myung Jun [Yonsei Univ. College of Medicine, Seoul (Korea, Republic of); Won, Je Hwan [Ajou Univ. College of Medicine, Suwon (Korea, Republic of); Kang, Byung Chul [Ewha Womans Univ. College of Medicine, Seoul (Korea, Republic of)

    1999-09-01

    To determine the efficacy and clinical outcome of uterine arterial embolization as a new approach to the management of uterine leiomyomas. Uterine arterial embolization was performed in 21 patients aged 26-62(mean, 42) years. Twenty of these had menorrhagia, dysmenorrhea, and mass-related symptoms (low abdominal discomfort, backache, urinary frequency, etc.) and one was diagnosed incidentally. Bilateral uterine arteries were selected individually and polyvinyl alcohol and/or gelfoam was used as an embolic material. Nineteen patients were followed up after embolization. Seventeen (89.5 %)reported satisfactory improvement of symptoms and follow-up sonography three months later showed a 58.5 % reduction in mean myoma volume. In 17 patients (89.5 %), the menstrual cycle returned to normal. All patients experienced pain after the procedure and other complications were vaginal bleeding (26.3 %) and fever (23.8 %). Uterine arterial embolization represents a new approach to the management of uterine leiomyoma-related symptoms. Further investigations and long-term follow-up are, however, enquired.

  2. Uterine arterial embolization for uterine leiomyoma: efficacy and clinical outcome

    International Nuclear Information System (INIS)

    To determine the efficacy and clinical outcome of uterine arterial embolization as a new approach to the management of uterine leiomyomas. Uterine arterial embolization was performed in 21 patients aged 26-62(mean, 42) years. Twenty of these had menorrhagia, dysmenorrhea, and mass-related symptoms (low abdominal discomfort, backache, urinary frequency, etc.) and one was diagnosed incidentally. Bilateral uterine arteries were selected individually and polyvinyl alcohol and/or gelfoam was used as an embolic material. Nineteen patients were followed up after embolization. Seventeen (89.5 %)reported satisfactory improvement of symptoms and follow-up sonography three months later showed a 58.5 % reduction in mean myoma volume. In 17 patients (89.5 %), the menstrual cycle returned to normal. All patients experienced pain after the procedure and other complications were vaginal bleeding (26.3 %) and fever (23.8 %). Uterine arterial embolization represents a new approach to the management of uterine leiomyoma-related symptoms. Further investigations and long-term follow-up are, however, enquired

  3. Should helical tomotherapy replace brachytherapy for cervical cancer? Case report

    Directory of Open Access Journals (Sweden)

    Chen Yu-Jen

    2010-11-01

    Full Text Available Abstract Background Stereotactic body radiation therapy (SBRT administered via a helical tomotherapy (HT system is an effective modality for treating lung cancer and metastatic liver tumors. Whether SBRT delivered via HT is a feasible alternative to brachytherapy in treatment of locally advanced cervical cancer in patients with unusual anatomic configurations of the uterus has never been studied. Case Presentation A 46-year-old woman presented with an 8-month history of abnormal vaginal bleeding. Biopsy revealed squamous cell carcinoma of the cervix. Magnetic resonance imaging (MRI showed a cervical tumor with direct invasion of the right parametrium, bilateral hydronephrosis, and multiple uterine myomas. International Federation of Gynecology and Obstetrics (FIGO stage IIIB cervical cancer was diagnosed. Concurrent chemoradiation therapy (CCRT followed by SBRT delivered via HT was administered instead of brachytherapy because of the presence of multiple uterine myomas with bleeding tendency. Total abdominal hysterectomy was performed after 6 weeks of treatment because of the presence of multiple uterine myomas. Neither pelvic MRI nor results of histopathologic examination at X-month follow-up showed evidence of tumor recurrence. Only grade 1 nausea and vomiting during treatment were noted. Lower gastrointestinal bleeding was noted at 14-month follow-up. No fistula formation and no evidence of haematological, gastrointestinal or genitourinary toxicities were noted on the most recent follow-up. Conclusions CCRT followed by SBRT appears to be an effective and safe modality for treatment of cervical cancer. Larger-scale studies are warranted.

  4. Should helical tomotherapy replace brachytherapy for cervical cancer? Case report

    International Nuclear Information System (INIS)

    Stereotactic body radiation therapy (SBRT) administered via a helical tomotherapy (HT) system is an effective modality for treating lung cancer and metastatic liver tumors. Whether SBRT delivered via HT is a feasible alternative to brachytherapy in treatment of locally advanced cervical cancer in patients with unusual anatomic configurations of the uterus has never been studied. A 46-year-old woman presented with an 8-month history of abnormal vaginal bleeding. Biopsy revealed squamous cell carcinoma of the cervix. Magnetic resonance imaging (MRI) showed a cervical tumor with direct invasion of the right parametrium, bilateral hydronephrosis, and multiple uterine myomas. International Federation of Gynecology and Obstetrics (FIGO) stage IIIB cervical cancer was diagnosed. Concurrent chemoradiation therapy (CCRT) followed by SBRT delivered via HT was administered instead of brachytherapy because of the presence of multiple uterine myomas with bleeding tendency. Total abdominal hysterectomy was performed after 6 weeks of treatment because of the presence of multiple uterine myomas. Neither pelvic MRI nor results of histopathologic examination at X-month follow-up showed evidence of tumor recurrence. Only grade 1 nausea and vomiting during treatment were noted. Lower gastrointestinal bleeding was noted at 14-month follow-up. No fistula formation and no evidence of haematological, gastrointestinal or genitourinary toxicities were noted on the most recent follow-up. CCRT followed by SBRT appears to be an effective and safe modality for treatment of cervical cancer. Larger-scale studies are warranted

  5. Excessive uterine bleeding.

    Science.gov (United States)

    Talib, Hina J; Coupey, Susan M

    2012-04-01

    Menstrual bleeding that falls outside the range of normal in adolescents is often a cause of great concern for both girls and their families. Often, much of this anxiety can be alleviated with proper anticipatory guidance about menarche and early menstrual bleeding patterns. Eliciting a menstrual history from an adolescent girl is challenging, and the use of concrete methods to chart their patterns and flow, such as menstrual calendars and pictorial bleeding assessment calendar (PBAC) tools, may be helpful. The importance of obtaining a confidential history from the adolescent girl cannot be overestimated. A confidential sexual history is essential so that pregnancy and infectious causes of bleeding are addressed. Not all menstrual bleeding in young girls is attributable to immaturity of the HPO axis. Anovulation and DUB from other clinically relevant conditions in adolescent girls must also be considered. Chief among these is PCOS, which should always be ruled out when a girl presents with excessive bleeding associated with clinical signs of hyperandrogenism, obesity, or insulin resistance. Attention must also be paid to signs or a family history of a bleeding disorder, as vWD is commonly associated with excessive uterine bleeding. Importantly, the laboratory testing for both PCOS and vWD is affected by therapies for the excessive bleeding, and it should be performed before hormonal interventions or blood products are administered or during the placebo phase if treatment has begun. Management goals for excessive uterine bleeding include stabilizing the endometrium and stopping further blood loss, as well as preventing future uncontrolled blood loss. Hormonal stabilization of the endometrium is often helpful regardless of the cause of bleeding and especially in those with hormonally mediated anovulation. New antifibrinolytics, such as tranexamic acid, may also be helpful in the emergent setting and in adolescents with bleeding disorders. PMID:22764555

  6. Uterine inhibitory effect of reticuline.

    Science.gov (United States)

    Martin, M L; Sagredo, J A; Morais, J M; Montero, M J; Sanchez, M T; San Roman, L

    1988-11-01

    Reticuline, the most abundant benzylisoquinoleic alkaloid of Laurobasidium lauri, exerts a uterine inhibitory effect mainly related to a decrease in the concentration of cytosolic calcium available for contraction. PMID:2907562

  7. Carcinoma of the uterine cervix

    International Nuclear Information System (INIS)

    There are few reports on uterine cancer in relation to radiation. This chapter discusses uterine cancer in A-bomb survivors, with special reference to the mortality rate, in a review of the literature. The Atomic Bomb Casualty Commission has first discovered 28 cases of uterine cancer among A-bomb survivors during the period 1953-1957. Since 1970, mortality rate from uterine cancer has been investigated statistically according to the T65D system. The Radiation Effect Research Foundation (RERF) has revealed 282 death cases from uterine cancer during the period 1950-1974. The RERF's data up to 1982 has revealed no radiation-dependent mortality from uterine cancer. More recent data (1950-1985) has revealed that mortality rate was increased by 22% in A-bomb survivors exposed to 1 Gy or more. When mortality of uterine cancer was investigated statistically using the 1968-1982 data for the population of the Research Institute for Nuclear Medicine and Biology, Hiroshima University, it was 1.2 times higher in the entire exposed group and 1.4 times higher in the group of proximally exposed A-bomb survivors (within 2 km from the hypocenter) than the non-exposed group, with statistically significant difference. It tended to be high in the group of distally exposed A-bomb survivors (who entered the city within 3 days after A-bombing) than the non-exposed group. When comparing the group of Hiroshima City with the group of Hiroshima Prefecture, mortality from uterine cancer was 1.3 times higher in the municipal group for proximally exposed A-bomb survivors and 1.3 times higher in the prefectural group for distally exposed A-bomb survivors and the others. Mortality rate was highest within one year after the acquisition of health handbook in the exposed group. (N.K.)

  8. Uterine prolapse in pregnancy: risk factors, complications and management.

    Science.gov (United States)

    Tsikouras, Panagiotis; Dafopoulos, Alexandros; Vrachnis, Nikolaos; Iliodromiti, Zoe; Bouchlariotou, Sofia; Pinidis, Petros; Tsagias, Nikolaos; Liberis, Vasileios; Galazios, Georgios; Von Tempelhoff, Georg Friedrich

    2014-02-01

    Presentation of uterine prolapse is a rare event in a pregnant woman, which can be pre-existent or else manifest in the course of pregnancy. Complications resulting from prolapse of the uterus in pregnancy vary from minor cervical infection to spontaneous abortion, and include preterm labor and maternal and fetal mortality as well as acute urinary retention and urinary tract infection. Moreover, affected women may be at particular risk of dystocia during labor that could necessitate emergency intervention for delivery. Recommendations regarding the management of this infrequent but potentially harmful condition are scarce and outdated. This review will examine the causative factors of uterine prolapse and the antepartum, intrapartum and puerperal complications that may arise from this condition as well as therapeutic options available to the obstetrician. While early recognition and appropriate prenatal management of uterine prolapse during pregnancy is imperative, implementation of conservative treatment modalities throughout pregnancy, these applied in accordance with the severity of the uterus prolapse and the patient's preference, may be sufficient to achieve uneventful pregnancy and normal, spontaneous delivery. PMID:23692627

  9. Erosion protection

    International Nuclear Information System (INIS)

    All earth dams require protection against erosion due to wave action on the upstream slope and protection against runoff from rain, snowmelt or wave splash on the downstream shell. Erosion protection is a major cost factor in embankment dams, typically varying from 5-15% of the dam cost, although it can approach 50% of embankment cost for long low dikes. The most common type of erosion protection is dumped rock riprap. Current practice in riprap design is based on rational analysis of factors affecting riprap stability, and the performance of existing riprap protection. Historical development of riprap design is reviewed, beginning with U.S. Army Corps of Engineers dams in the 1940s. Riprap design parameters are based on slope steepness and severity of wave action, which depends on reservoir geometry and location. A common cause of riprap deterioration is loss of underlying bedding as a result of inadequate design or segregation of riprap and bedding during construction. The most common form of riprap failures include: loss of filter material through riprap if it is too fine; inadequate rock size to resist wave action, resulting in beaching; segregation during construction, resulting in pockets of undersized rock which can expose the underlying filter, and pockets of oversized rock through which bedding can wash out; breakdown of poor quality stone due to prolonged exposure and wave action; and failure to extend the primary riprap far enough downslope to be below the level of wave action at low reservoir levels. 26 refs., 8 figs

  10. Detection of Human Papillomavirus in Chronic Cervicitis, Cervical Adenocarcinoma, Intraepithelial Neoplasia and Squamus Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Elahe Mirzaie-Kashani

    2014-05-01

    Full Text Available Background: Cervical cancer is the second most common cancer in women worldwide. Recent studies show that human papillomavirus (HPV DNA is present in all cervical carcinomas and in some cervicitis cases, with some geographical variation in viral subtypes. Therefore determination of the presence of HPV in the general population of each region can help reveal the role of these viruses in tumors. Objectives: This study aimed to estimate the frequency of infection with HPV in cervicitis, cervical adenocarcinoma, intraepithelial neoplasia and squamus cell carcinoma samples from the Isfahan Province, Iran. Patients and Methods: One hundred and twenty two formalin fixed paraffin embedded tissue samples of crevicitis cases and different cervix tumors including cervical intraepithelial neoplasia (CIN (I, II, III, squamus cell carcinoma (SCC and adenocarcinoma were collected from histopathological files of Al-Zahra Hospital in Isfahan. Data about histopathological changes were collected by reexamination of the hematoxylin and eosin stained sections. DNA was extracted and subjected to Nested PCR using consensus primers, MY09/MY11 and GP5+/GP6+, designed for amplification of a conserved region of the genome coding for L1 protein. Results: In total 74.5% of the tested samples were positive for HPV. Amongst the tested tumors 8 out of 20 (40% of CIN (I, II, III, 5 out of 21 (23.8% of adenocarcinoma cases and 78 out of 79 chronic cervicitis cases were positive for HPV. Conclusions: The rate of different carcinomas and also the rate of HPV infection in each case were lower than other reports from different countries. This could be correlated with the social behavior of women in the area, where they mostly have only one partner throughout their life, and also the rate of smoking behavior of women in the studied population. On the other hand the rate of HPV infection in chronic cervicitis cases was much higher than cases reported by previous studies. This necessitates more attention to the role of human papillomaviruses in the their induction in the studied area. Keywords: Polymerase Chain Reaction; Uterine Cervical Neoplasms; Uterine Cervicitis

  11. Lynch syndrome and cervical cancer.

    Science.gov (United States)

    Antill, Yoland C; Dowty, James G; Win, Aung Ko; Thompson, Tina; Walsh, Michael D; Cummings, Margaret C; Gallinger, Steven; Lindor, Noralane M; Le Marchand, Loïc; Hopper, John L; Newcomb, Polly A; Haile, Robert W; Church, James; Tucker, Katherine M; Buchanan, Daniel D; Young, Joanne P; Winship, Ingrid M; Jenkins, Mark A

    2015-12-01

    Carriers of germline mutations in DNA mismatch repair (MMR) genes are at increased risk of several cancers including colorectal and gynecologic cancers (Lynch syndrome). There is no substantial evidence that these mutations are associated with an increased risk of cervical cancer. A total of 369 families with at least one carrier of a mutation in a MMR gene (133 MLH1, 174 MSH2, 35 MSH6 and 27 PMS2) were ascertained via population cancer registries or via family cancer clinics in Australia, New Zealand, Canada, and USA. Personal and family histories of cancer were obtained from participant interviews. Modified segregation analysis was used to estimate the hazard ratio (incidence rates for carriers relative to those for the general population), and age-specific cumulative risks of cervical cancer for carriers. A total of 65 cases of cervical cancer were reported (including 10 verified by pathology reports). The estimated incidence was 5.6 fold (95% CI: 2.3-13.8; p = 0.001) higher for carriers than for the general population with a corresponding cumulative risk to 80 years of 4.5% (95% CI: 1.9-10.7%) compared with 0.8% for the general population. The mean age at diagnosis was 43.1 years (95% CI: 40.0-46.2), 3.9 years younger than the reported USA population mean of 47.0 years (p = 0.02). Women with MMR gene mutations were found to have an increased risk of cervical cancer. Due to limited pathology verification we cannot be certain that a proportion of these cases were not lower uterine segment endometrial cancers involving the endocervix, a recognized cancer of Lynch syndrome. PMID:26077226

  12. Uncommon sarcomas of the uterine cervix: a review of selected entities

    OpenAIRE

    Fadare Oluwole

    2006-01-01

    Abstract Sarcomas constitute less than 1% of all cervical malignancies. With over 150 reported cases, rhabdomyosarcomas represent the most commonly reported sarcoma at this location. In this report, a select group of the more uncommon sarcomas of the uterine cervix are reviewed, including all previously reported examples of leiomyosarcoma, liposarcoma, alveolar soft part sarcoma, Ewing sarcoma/primitive neuroectodermal tumor, undifferentiated endocervical sarcoma, and malignant peripheral ner...

  13. Cervical Collagen Concentration within Fifteen Months after Delivery

    DEFF Research Database (Denmark)

    Sundtoft, Iben; Uldbjerg, Niels; Sommer, Steffe

    2011-01-01

    OBJECTIVE: Cervical collagen concentration decreases during pregnancy. The increased risk of preterm birth following a short interpregnancy interval may be explained by an incomplete remodeling of the cervix. The objective of this study was to describe the changes in cervical collagen concentration...... over 15 months following delivery. METHODS: The collagen concentrations were determined in cervical biopsies obtained from 15 women at 3, 6, 9, 12, and 15 months after delivery. RESULTS: The mean cervical collagen concentrations were 50, 59, 63, 65, and 65 % of dry weight (SD 4.2 – 6.5). This increase...... was statistically significant until month 9, but not between months 9 and 12. CONCLUSIONS: Low collagen concentrations in the uterine cervix may contribute to the association between a short interpregnancy interval and preterm birth....

  14. Integrative review of the nursing interventions used for the early detection of cervical uterine cancer / Revisión integradora de las intervenciones de enfermería utilizadas para detección precoz del cáncer cervicouterino / Revisão integrativa das intervenções de enfermagem utilizadas para detecção precoce do câncer cérvico-uterino

    Scientific Electronic Library Online (English)

    Camila Teixeira Moreira, Vasconcelos; Marta Maria Coelho, Damasceno; Francisca Elisângela Teixeira, Lima; Ana Karina Bezerra, Pinheiro.

    2011-04-01

    Full Text Available Em um programa nacional de combate ao câncer cérvico-uterino (CCU) devem existir quatro elementos básicos: prevenção primária, detecção precoce, diagnóstico/tratamento e cuidados paliativos. Desses, a detecção precoce é a modalidade mais efetiva. Um dos propósitos da Prática Baseada em Evidências é [...] encorajar a utilização de resultados de pesquisa junto à assistência prestada, reforçando a importância da pesquisa para a prática clínica. Esse estudo objetivou avaliar as evidências disponíveis na literatura sobre as intervenções de enfermagem eficazes na detecção precoce do CCU. A seleção dos artigos foi realizada nas bases: Scopus, PubMed, CINAHL, LILACS e Cochrane. A amostra desta revisão constitui-se de 7 artigos, com níveis de evidência 1, 2 ou 3. Tanto as intervenções comportamentais como as cognitivas e sociais mostraram efeitos positivos na detecção precoce do CCU, com destaque para as intervenções cognitivas interativas. Sugere-se, quando adequado, utilizar combinação das intervenções para se obter resultado mais eficaz. Abstract in spanish En un programa nacional de combate al cáncer cervicouterino (CCU) deben existir cuatro elementos básicos: prevención primaria, detección precoz, diagnóstico/tratamiento y cuidados paliativos. De estos, la detección precoz es la modalidad más efectiva. Uno de los propósitos de la Práctica Basada en E [...] videncias es incentivar la utilización de resultados de investigación junto a la asistencia prestada, reforzando la importancia de la investigación para la práctica clínica. Este estudio objetivó evaluar las evidencias disponibles en la literatura sobre las intervenciones de enfermería eficaces en la detección precoz del CCU. La selección de los artículos fue realizada en las bases: Scopus, Pubmed, CINAHL, LILACS y Cochrane. La muestra de esta revisión se constituye de 7 artículos, con niveles de evidencia 1, 2 o 3. Tanto las intervenciones comportamentales, como las cognitivas y sociales mostraron efectos positivos en la detección precoz del CCU, con destaque para las intervenciones cognitivas interactivas. Se sugiere, cuando adecuado, utilizar una combinación de las intervenciones para obtener un resultado más eficaz. Abstract in english In a national program to combat cervical uterine cancer (CUC) four basic elements should exist: primary prevention, early detection, diagnosis/treatment and palliative care. Of these, early detection is the most effective modality. One of the purposes of Evidence-Based Practice (EBP) is to encourage [...] the use of research results with the assistance provided, reinforcing the importance of research for clinical practice. This study aimed to evaluate the evidence available in the literature regarding effective nursing interventions for the early detection of CUC. The selection of articles was performed in the databases: Scopus, PubMed, CINAHL, Lilacs and Cochrane. The sample of this review consisted of seven articles, with evidence levels 1, 2 or 3. The behavioral, cognitive and social interventions, showed positive effects in the early detection of CUC, especially the interactive cognitive interventions. It is suggested, when appropriate, to use a combination of interventions in order to obtain a more effective result.

  15. Epidemiology of Malignant Cervical, Corpus Uteri and Ovarian Tumours – Current Data and Epidemiological Trends

    OpenAIRE

    Waldmann, A.; Eisemann, N.; Katalinic, A

    2013-01-01

    Cervical, uterine and ovarian cancers are the most common malignancies of the female genital tract. Using current data from population-based cancer registries in Germany, we present the recent figures for the incidence, prevalence, associated mortality and survival for these cancers. In 2009, a total of 23?800 women were newly diagnosed with one of the three gynaecological cancers (cervical cancer: 20.3?%, endometrial cancer: 48.5?%, ovarian cancer: 31.2?%). This figure equa...

  16. Cerebral metastasis of cervical cancer, report of two cases and review of the literature

    OpenAIRE

    Setoodeh, Reza; HAKAM, Ardeshir; Shan, Yuan

    2012-01-01

    Cervical cancers spread locally through the angiolymphatic apparatus and very rarely metastasize to the brain. The intracranial metastasis is a late event and a sign of poor prognosis. We present two cases of uterine cervical carcinomas with brain metastasis presenting with severe headaches in one case and hemiparesis and aphasia in the other one. Palliative craniotomy and debulking of the tumor was performed in both patients.

  17. Cervical Spondylotic Myelopathy (CSM)

    Science.gov (United States)

    MENU Return to Web version Cervical Spondylotic Myelopathy Overview What is cervical spondylotic myelopathy? Cervical spondylotic myelopathy (CSM) is a compression of the spinal cord in the neck. (When ...

  18. Cervical Cancer Stage IIIA

    Science.gov (United States)

    ... My Pictures Browse Search Quick Search Image Details Cervical Cancer Stage IIIA View/Download: Small: 612x612 View Download Add to My Pictures Title: Cervical Cancer Stage IIIA Description: Stage IIIA cervical cancer; drawing ...

  19. Cervical Cancer Stage IA

    Science.gov (United States)

    ... My Pictures Browse Search Quick Search Image Details Cervical Cancer Stage IA View/Download: Small: 720x576 View Download Add to My Pictures Title: Cervical Cancer Stage IA Description: Stage IA1 and IA2 cervical ...

  20. Cervical Cancer Stage IVB

    Science.gov (United States)

    ... My Pictures Browse Search Quick Search Image Details Cervical Cancer Stage IVB View/Download: Small: 594x640 View Download Add to My Pictures Title: Cervical Cancer Stage IVB Description: Stage IVB cervical cancer; drawing ...

  1. Cervical Cancer Stage IIIB

    Science.gov (United States)

    ... My Pictures Browse Search Quick Search Image Details Cervical Cancer Stage IIIB View/Download: Small: 684x636 View Download Add to My Pictures Title: Cervical Cancer Stage IIIB Description: Stage IIIB cervical cancer; drawing ...

  2. Cervical Cancer Stage IB

    Science.gov (United States)

    ... My Pictures Browse Search Quick Search Image Details Cervical Cancer Stage IB View/Download: Small: 774x576 View Download Add to My Pictures Title: Cervical Cancer Stage IB Description: Stage IB1 and IB2 cervical ...

  3. Cervical Cancer Stage IVA

    Science.gov (United States)

    ... Search Quick Search Image Details Cervical Cancer Stage IVA View/Download: Small: 756x576 View Download Add to My Pictures Title: Cervical Cancer Stage IVA Description: Stage IVA cervical cancer; drawing and inset ...

  4. [Cervical radiculopathy].

    Science.gov (United States)

    Kuijper, B

    2014-10-01

    Cervical radiculopathy is a common cause of pain in the arm. It is caused by nerve root compression in the neck, as a consequence of a herniated disc, or spondyliotic foraminal stenosis. It causes severe pain, especially during the first few weeks, and paraesthesias in the forearm and hand. Patients also suffer from neck pain and loss of strength in the relevant arm. The arm pain can be exacerbated by certain movements of the head; these should be avoided as much as possible. Diagnosis can be made on the basis of history and physical examination. The pain generally disappears without active patient treatment. A semi-rigid cervical collar is recommended to accelerate pain relief. In cases of persistent pain, surgery will be considered. In such cases an MRI should be performed to show the cause and level of nerve root compression. PMID:26185991

  5. Pregnancy after uterine arterial embolization

    Directory of Open Access Journals (Sweden)

    Cláudio E. Bonduki

    2011-01-01

    Full Text Available OBJECTIVE: To evaluate pregnancy outcomes, complications and neonatal outcomes in women who had previously undergone uterine arterial embolization. METHODS: A retrospective study of 187 patients treated with uterine arterial embolization for symptomatic uterine fibroids between 2005-2008 was performed. Uterine arterial embolization was performed using polyvinyl alcohol particles (500-900 mm in diameter. Pregnancies were identified using screening questionnaires and the study database. RESULTS: There were 15 spontaneous pregnancies. Of these, 12.5% were miscarriages (n = 2, and 87.5% were successful live births (n = 14. The gestation time for the pregnancies with successful live births ranged from 36 to 39.2 weeks. The mean time between embolization and conception was 23.8 months (range, 5-54. One of the pregnancies resulted in twins. The newborn weights (n = 14 ranged from 2.260 to 3.605 kg (mean, 3.072 kg. One (7.1% was considered to have a low birth weight (2.260 kg. There were two cases of placenta accreta (12.5%, treated with hysterectomy in one case [6.3%], one case of premature rupture of the membranes (PRM (6.3%, and one case of preeclampsia (6.3%. All of the patients were delivered via Cesarean section. CONCLUSION: In this study, there was an increased risk of Cesarean delivery. There were no other major obstetric risks, suggesting that pregnancy after uterine arterial embolization is possible without significant morbidity or mortality.

  6. Pregnancy after uterine arterial embolization

    Scientific Electronic Library Online (English)

    Cláudio E., Bonduki; Paulo C., Feldner, Jr.; Juliana da, Silva; Rodrigo A., Castro; Marair G. F., Sartori; Manoel J. B. C., Girão.

    Full Text Available OBJECTIVE: To evaluate pregnancy outcomes, complications and neonatal outcomes in women who had previously undergone uterine arterial embolization. METHODS: A retrospective study of 187 patients treated with uterine arterial embolization for symptomatic uterine fibroids between 2005-2008 was perform [...] ed. Uterine arterial embolization was performed using polyvinyl alcohol particles (500-900 mm in diameter). Pregnancies were identified using screening questionnaires and the study database. RESULTS: There were 15 spontaneous pregnancies. Of these, 12.5% were miscarriages (n = 2), and 87.5% were successful live births (n = 14). The gestation time for the pregnancies with successful live births ranged from 36 to 39.2 weeks. The mean time between embolization and conception was 23.8 months (range, 5-54). One of the pregnancies resulted in twins. The newborn weights (n = 14) ranged from 2.260 to 3.605 kg (mean, 3.072 kg). One (7.1%) was considered to have a low birth weight (2.260 kg). There were two cases of placenta accreta (12.5%, treated with hysterectomy in one case [6.3%]), one case of premature rupture of the membranes (PRM) (6.3%), and one case of preeclampsia (6.3%). All of the patients were delivered via Cesarean section. CONCLUSION: In this study, there was an increased risk of Cesarean delivery. There were no other major obstetric risks, suggesting that pregnancy after uterine arterial embolization is possible without significant morbidity or mortality.

  7. The treatment of uterine sarcomas.

    Science.gov (United States)

    Reichardt, P

    2012-09-01

    Uterine sarcomas are rare and comprise only 3% of all uterine cancers. Within the group of adult soft tissue sarcomas, they account for ?7% of new cases. They consist of several distinct histological subtypes like leiomyosarcoma, endometrial stromal tumors, undifferentiated sarcomas, pure heterologous sarcomas, and mixed epithelial and mesenchymal tumors. Standard treatment in localized disease is abdominal hysterectomy. Bilateral salpingo-oophorectomy and lymphadenectomy have no proven value in leiomyosarcomas and high-grade undifferentiated sarcomas. However, in endometrial stromal tumors, given the hormonal reponsiveness of most tumors, salpingo-oophorectomy is generally recommended. Carcinosarcomas are treated according to current recommendations for epithelial uterine cancers. In leiomyosarcomas, postoperative radiation does not improve both relapse-free and overall survival. adjuvant chemotherapy seems to improve survival in the context of uncontrolled phase II trials. However, it is currently not considered standard of care in the absence of data from randomized trials. In contrast, adjuvant chemotherapy does improve overall survival in carcinosarcomas and is therefore considered standard of care. Systemic therapy for advanced uterine leiomyosarcomas, undifferentiated uterine sarcomas, and heterologous sarcomas is generally following the recommendations for adult soft tissue sarcomas. Endometrial stromal sarcomas are usually hormonal receptor positive, which allows endocrine therapy in most cases. PMID:22987952

  8. Neuroendocrine differentiation in a case of cervical cancer

    Directory of Open Access Journals (Sweden)

    Mona Mohamed Rashed

    2010-07-01

    Full Text Available Neuroendocrine neoplasms may occur in the uterine cervix, although rarely; it accounts for 0.5-1% of all malignant tumors of the uterine cervix. A case report of an Ethiopian female presented at the Gynecology Out-Patient Clinic at Jimma University Hospital, complaining from irregular vaginal bleeding over the previous three months. Clinically there was a cauliflower cervical mass; histopathologically it was formed of sheets of small cell tumor; that further showed neuroendocrine differentiation, as demonstrated by chromogranin-A positivity. It is important to differentiate small cell carcinoma from other malignant tumors of the uterine cervix. Morphological features play an important role in making a diagnosis and the immunohistochemistry study can offer an additional useful assistance

  9. Evaluating the Feasibility of Acoustic Radiation Force Impulse Shear Wave Elasticity Imaging of the Uterine Cervix With an Intracavity Array: A Simulation Study

    OpenAIRE

    Palmeri, Mark L; Feltovich, Helen; Homyk, Andrew D.; Carlson, Lindsey C.; Hall, Timothy J.

    2013-01-01

    The uterine cervix softens, shortens, and dilates throughout pregnancy in response to progressive disorganization of its layered collagen microstructure. This process is an essential part of normal pregnancy, but premature changes are associated with preterm birth. Clinically, there are no reliable noninvasive methods to objectively measure cervical softening or assess cervical microstructure. The goal of these preliminary studies was to evaluate the feasibility of using an intracavity ultras...

  10. The intra-nucleus integration of mitochondrial DNA (mtDNA)in cervical mucosa cells and its relation with c-myc expression

    OpenAIRE

    Xiang Jinying; Xue Wenqun; Chen Daozhen

    2008-01-01

    Abstract Objective To explore the relationship between the integration of mitochondrial DNA(mtDNA) in the nuclei of cervical epithelium cells and the expression of c-myc. Methods The expression of c-myc protein was measured by immunohistochemical test in 40 cases of the uterine cervix cancer, 30 cases of cervical intraepithelial neoplasia (CIN) and 30 cases of normal cervical epithelium; the sequence of mtDNA in the nuclei was detected by in situ hybridization technique. Results The detection...

  11. Packing effects on the intracavitary radiation therapy of the uterine cervix cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jung Kun; Lee, Du Hyun; Si, Chang Kun; Choi, Yoon Kyung; Kim, Tae Yoon [Proton Therapy Center, National Cancer Center, Seoul (Korea, Republic of)

    2004-03-15

    Purpose of the radio-therapy is maximize the radiation dose to the tumor while minimizing the dose to the critical organ. Carcinoma of the uterine cervix treatment are external irradiation or an interstitial brachytherapy make use of isotope. Brachytherapy is a method of radiotherapy in advantage to achieve better local control with minimum radiation toxicity in comparison with external irradiation because radiation dose is distributed according to the inverse square low of gamma-ray emitted from the implanted sources. Authors make use of the patients data which {sup 192}Ir gives medical treatment intracavity. Intracavitary radiation of the uterine cervix cancer, critical organ take 20% below than exposure dose of A point in the ICRU report. None the less of the advice, Radiation proctitis and radiation cystitis are frequent and problematic early complications in patients treated with radiation for the uterine cervix cancer. In brachytherapy of uterine cervical cancer using a high dose rate remote afterloading system, it is of prime importance to deliver a accurate dose in each fractionated treatment by minimizing the difference between the pre-treatment planned and post-treatment calculated doses. Use of packing to reduce late complications intracavitary radiation of the uterine cervix cancer. Bladder and rectum changes exposure dose rate by radiotherapy make use of packing.

  12. Packing effects on the intracavitary radiation therapy of the uterine cervix cancer

    International Nuclear Information System (INIS)

    Purpose of the radio-therapy is maximize the radiation dose to the tumor while minimizing the dose to the critical organ. Carcinoma of the uterine cervix treatment are external irradiation or an interstitial brachytherapy make use of isotope. Brachytherapy is a method of radiotherapy in advantage to achieve better local control with minimum radiation toxicity in comparison with external irradiation because radiation dose is distributed according to the inverse square low of gamma-ray emitted from the implanted sources. Authors make use of the patients data which 192Ir gives medical treatment intracavity. Intracavitary radiation of the uterine cervix cancer, critical organ take 20% below than exposure dose of A point in the ICRU report. None the less of the advice, Radiation proctitis and radiation cystitis are frequent and problematic early complications in patients treated with radiation for the uterine cervix cancer. In brachytherapy of uterine cervical cancer using a high dose rate remote afterloading system, it is of prime importance to deliver a accurate dose in each fractionated treatment by minimizing the difference between the pre-treatment planned and post-treatment calculated doses. Use of packing to reduce late complications intracavitary radiation of the uterine cervix cancer. Bladder and rectum changes exposure dose rate by radiotherapy make use of packing.

  13. Cervical Laminoplasty for Multilevel Cervical Myelopathy

    OpenAIRE

    Murali Krishna Sayana; Hassan Jamil; Ashley Poynton

    2011-01-01

    Cervical spondylotic myelopathy can result from degenerative cervical spondylosis, herniated disk material, osteophytes, redundant ligamentum flavum, or ossification of the posterior longitudinal ligament. Surgical intervention for multi-level myelopathy aims to decompress the spinal cord and maintain stability of the cervical spine. Laminoplasty was major surgical advancement as laminectomy resulted in kyphosis and unsatisfactory outcomes. Hirabayashi popularised the expansive open door lami...

  14. [Anti-HPV vaccination: preventing cervical cancer].

    Science.gov (United States)

    Simon, P; Dupond, I

    2006-09-01

    Two anti-HPV vaccine will soon be registered on the Belgian market. Providing immunity against the L1 protein of several oncogenic types of Papilloma virus, they aim at protecting against cervical cancer and several precancerous lesions. It has been known for years that oncogenic HPV infection of the uterine cervix is a prerequisite to the development of cervical cancer. This is supported by epidemiological has well as biological observations. That is why vaccines against capsid protein of these viruses had been developed. Two of these vaccines are about to be registered in Belgium. Cervarix (GSK) is directed against HPV 16 and 18 which are associated to ca 70% of the cervical cancers in the world. Gardasil (Sanofi Pasteur MSD) propose a vaccination against L1 protein of HPV 16 and 18, but also against HPV 6 and 11 which are responsible of benign lesions of the ano genital area (condylomas). The results obtained so far are very promising considering their preventive efficacy on persistant infections and cervical dysplasias. Two recent publications must be discussed: first, the protection offered by Cervarix is maintained for 4.5 years at least, second, vaccination by Gardasil of patients already infected by one of the HPV types (16, 18, 6, 11) provides a 100% efficacy in preventing diseases caused by the remaining types. It is therefore probable that HPV vaccination will not only concerns naive patients from any contact with HPV but also patients having already be in contact with these viruses. PMID:17091900

  15. Uterine fibromyolipoma; Uncommon imaging features

    Energy Technology Data Exchange (ETDEWEB)

    Soyer, P.; Masselot, J.; Vanel, D. (Centre de Lutte Contre le Cancer Gustave-Roussy, 94 - Villejuif (France)); Harry, G. (Centre Hospitalier General de Creil (France). Department of Radiology); Cazier, A. (Centre Hospitalier General de Creil (France). Department of Pathology)

    Lipomatous tumors of the uterus are uncommon. Because of the fatty nature of those tumors, digital imaging techniques may provide the preoperative diagnosis. A case of uterine fibromyolipoma is reported, documented by both ultrasound (US) and computed tomography (CT), in which the diagnosis was strongly suggested by the US and CT findings. (author). 8 refs.; 2 figs.

  16. Concurrent chemoradiation therapy for advanced cervical cancer

    International Nuclear Information System (INIS)

    In 2003, we began a clinical application of concurrent chemoradiation therapy (CCR) in patients with cervical cancer in our hospital. We analyzed 14 cases of advanced cervical cancer in stages IIa through IIIb by International Federation of Gynecology and Obstetrics (FIGO) classification. Tumor size of the uterine cervix ranged from 1.5 cm to 8.0 cm in diameter. Patients received radiation therapy (50 Gy of external beam radiotherapy for pelvis and 20 Gy of high-dose rate intracavitary brachytherapy) combined with chemotherapy. Cisplatin was administered intravenously every 3 weeks at a dose of 70 mg/m2 during the radiation therapy. In two cases, CCR was stopped because of the side effects. One case developed acute renal failure and another suffered intolerable exhaustion. As for the antitumor effects of CCR, the response rate was 75% (complete response (CR) 58.3%, partial response (PR) 16.7%). At the end of the CCR, 10 of 12 patients (83.3%) were negative for viable cells by cytology or biopsy of the uterine cervix. The grade 3 adverse effects were leukopenia, diarrhea and anemia. There was no statistical difference in the overall survival between CCR and radiation therapy alone. The CCR response rate in patients with paraaortic lymph node swelling (suspected metastasis) was low, and they had a poor prognosis. Further examinations for the long-term survival benefit of CCR are necessary. (author)

  17. Erosion Effects

    Science.gov (United States)

    2003-01-01

    [figure removed for brevity, see original site] The impact crater in this THEMIS image is a model illustration to the effects of erosion on Mars. The degraded crater rim and several landslides observed in crater walls is evidence to the mass wasting of materials. Layering in crater walls also suggests the presence of materials that erode at varying rates.Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.Image information: VIS instrument. Latitude 31.6, Longitude 44.3 East (315.7 West). 19 meter/pixel resolution.

  18. Radial Erosion

    Science.gov (United States)

    2005-01-01

    [figure removed for brevity, see original site] The ejecta surrounding the crater (off image to the left) in this image has undergone significant erosion by the wind. The wind has stripped the surface features from the ejecta and has started to winnow away the ejecta blanket. Near the margin of the ejecta the wind is eroding along a radial pattern -- taking advantage of radial emplacement. Note the steep margin of the ejecta blanket. Most, if not all, of the fine ejecta material has been removed and the wind in now working on the more massive continuous ejecta blanket. Image information: VIS instrument. Latitude 12.5, Longitude 197.4 East (162.6 West). 37 meter/pixel resolution. Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time. NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

  19. Risks of Cervical Cancer Screening

    Science.gov (United States)

    ... Cervical Cancer Prevention Cervical Cancer Screening Research Cervical Cancer Screening–Patient Version (PDQ®) What is screening? Screening is ... the Pill"). Having a weakened immune system . Cervical Cancer Screening Key Points Tests are used to screen for ...

  20. An Industrial Dental-Erosion by Chromic Acid: A Case Report

    OpenAIRE

    Dülgergil, Ç. Türksel; Erdemir, Ebru Olgun; Ercan, Ertu?rul; Erdemir, Ali

    2007-01-01

    A case of uncommon occupational dental erosion was reported in an individual who had worked in the war industry for twenty years. This occupation involved daily, at least 8 hours, inhalation of chromic acid being used for cleaning of barrel of cannons. The erosion manifested as dental sensitivity with excessive cervical erosion even with pulpal exposure in certain teeth. Moreover, due to the adverse effect of the chemical against to gingival and/or periodontal tissues, the lesions were extrem...

  1. Preprocessing: A Step in Automating Early Detection of Cervical Cancer

    CERN Document Server

    Das, Abhishek; Bhattacharyya, Debasis

    2011-01-01

    Uterine Cervical Cancer is one of the most common forms of cancer in women worldwide. Most cases of cervical cancer can be prevented through screening programs aimed at detecting precancerous lesions. During Digital Colposcopy, colposcopic images or cervigrams are acquired in raw form. They contain specular reflections which appear as bright spots heavily saturated with white light and occur due to the presence of moisture on the uneven cervix surface and. The cervix region occupies about half of the raw cervigram image. Other parts of the image contain irrelevant information, such as equipment, frames, text and non-cervix tissues. This irrelevant information can confuse automatic identification of the tissues within the cervix. Therefore we focus on the cervical borders, so that we have a geometric boundary on the relevant image area. Our novel technique eliminates the SR, identifies the region of interest and makes the cervigram ready for segmentation algorithms.

  2. Preprocessing for Automating Early Detection of Cervical Cancer

    CERN Document Server

    Das, Abhishek; Bhattacharyya, Debasis

    2011-01-01

    Uterine Cervical Cancer is one of the most common forms of cancer in women worldwide. Most cases of cervical cancer can be prevented through screening programs aimed at detecting precancerous lesions. During Digital Colposcopy, colposcopic images or cervigrams are acquired in raw form. They contain specular reflections which appear as bright spots heavily saturated with white light and occur due to the presence of moisture on the uneven cervix surface and. The cervix region occupies about half of the raw cervigram image. Other parts of the image contain irrelevant information, such as equipment, frames, text and non-cervix tissues. This irrelevant information can confuse automatic identification of the tissues within the cervix. Therefore we focus on the cervical borders, so that we have a geometric boundary on the relevant image area. Our novel technique eliminates the SR, identifies the region of interest and makes the cervigram ready for segmentation algorithms.

  3. Psychological effects of diagnosis and treatment of cervical intraepithelial neoplasia

    DEFF Research Database (Denmark)

    Frederiksen, Maria Eiholm; Njor, Sisse; Lynge, Elsebeth; Rebolj, Matejka

    2015-01-01

    statistical testing, we estimated the statistical significance of the differences between the compared groups using unpaired t tests. MAIN RESULTS: From 5099 retrieved abstracts, 16 studies were included. Diagnosis and treatment of CIN were associated with worse psychological outcomes than normal cytology......BACKGROUND: Treatment of cervical intraepithelial neoplasia (CIN) is a common minor surgical procedure to prevent uterine cervical cancer. However, news of an abnormality detected at screening for cancer might cause the woman to worry. OBJECTIVES: To investigate the psychological consequences of...... psychological outcomes in women with a histological diagnosis or treatment of CIN, and in women having an outcome other than CIN at cervical screening. DATA COLLECTION AND ANALYSIS: We abstracted the data using a pre-specified list of study characteristics and measured outcomes. For studies not reporting...

  4. Paraaortic lymph node irradiation in cervical carcinoma without prior lymphadenectomy

    International Nuclear Information System (INIS)

    A study of complications associated with paraaortic irradiation was undertaken in patients with uterine cervical cancer who had not undergone prior lymphadenectomy. Between 1975 and 1984, 29 highly selected patients received paraaortic irradiation as part of their definitive treatment for cervical carcinoma. Paraaortic fields were irradiated to a total dose of 4,200-5,000 rad (42-50 Gy), in fractions of 150-180 rad (1.5-1.8 Gy). An anteroposterior-posteroanterior technique was generally used. All fields were treated every day. There were no instances of small-bowel obstruction or other major complications, surgical procedures, or deaths caused by paraaortic irradiation. Eleven patients (38%) have no evidence of recurrent disease 23-120 months after completion of therapy. Paraaortic irradiation was well tolerated in this patient group without prior staging lymphadenectomy. Thus, in selected patients and with appropriate techniques, paraaortic irradiation for cervical carcinoma may be used with relative safety

  5. Tissue and serum fluorescence spectroscopy as a marker to monitor radiation therapy in cancer of human uterine cervix

    International Nuclear Information System (INIS)

    During the development of neoplasia epithelial tissues undergo biochemical and structural changes that can manifest in tissue auto-fluorescence. Several research groups have reported the tissue fluorescence spectroscopy for the discrimination of carcinoma or human uterine cervix. And also there have been several reports on using different biomarkers for the detection of cervical cancer. It is attempted to make use of fluorescence spectroscopy technique to monitor the radiation therapy in patients with squamous cell carcinoma of cervix. The clinical samples from 10 patients with stage II and stage III B cervical cancer were analysed. The results showed significant changes in spectral characteristics in tissue fluorescence before and after radiation

  6. Papillary thyroid carcinoma with massive metastasis in the uterine corpus: a case report

    International Nuclear Information System (INIS)

    Distant metastases stemming from a papillary thyroid carcinoma (PTC) are quite rare. Here we report an exceptional case of PTC presenting with cervical lymphatic and uterine metastases. This is the first case report of a PTC with uterine involvement. A 60-year-old Chinese woman came to our hospital complaining of discomfort in the throat that she had been experiencing for about half a month. PTC and cervical lymphatic metastasis were diagnosed after ultrasound examinations. A massive heterogeneous mass was found beside the uterus during the pre-operative checkup and a diagnosis of ovarian carcinoma was suspected after a thorough case discussion. However, it proved to be a metastasis from the PTC as determined by pathological and immunohistochemical examinations after the operation. The patient declined further treatments. She was followed for 22 months with no sign of recurrence detected. In this report, an unusual case of PTC was presented. The patient had not only regional lymphatic metastasis, but also had a massive metastasis in the uterine corpus, which was initially misdiagnosed as ovarian carcinoma. This case is of interest because of its rarity and exceptionally good prognosis. The reason for the misdiagnosis was attributed to overlooking the possibility of a distant metastasis coming from a PTC. This case raises the issue that completing an iodine-131 scan before operating on patients with PTC may be warranted

  7. Mapping erosion from space

    OpenAIRE

    Vrieling, A.

    2007-01-01

    Soil erosion by water is the most important land degradation problem worldwide. Spatial information on erosion is required for defining effective soil and water conservation strategies. Satellite remote sensing can provide relevant input to regional erosion assessment. This thesis comprises a review on how satellite data have been used previously for evaluating water erosion. Options include erosion detection and the assessment of controlling factors such as topography, soil, and vegetation. ...

  8. Soil Erosion Studies

    OpenAIRE

    GODONE, DANILO FRANCESCO; STANCHI, SILVIA

    2011-01-01

    Soil erosion affects a large part of the Earth surface, and accelerated soil erosion is recognized as one of the main soil threats, compromising soil productive and protective functions. The land management in areas affected by soil erosion is a relevant issue for landscape and ecosystems preservation. In this book we collected a series of papers on erosion, not focusing on agronomic implications, but on a variety of other relevant aspects of the erosion phenomena. The book is divided into th...

  9. Identification of biomechanical properties in vivo in human uterine cervix

    DEFF Research Database (Denmark)

    Liao, Donghua; Hee, Lene

    2014-01-01

    BACKGROUND AND AIMS: The course and outcome of pregnancy is closely correlated to change of biomechanical properties of the uterine cervix. The aim of this study was to build a non-linear, fiber reinforced mechanical model of the cervix for estimation of mechanical characteristics of the cervix in early- and term-pregnant women based on recordings of in vivo pressure and diameter by means of the Functional Luminal Imaging Probe (FLIP) technology. MATERIALS AND METHODS: Five early- and six term-pregnant women were examined with a FLIP probe. The bag on the probe was inserted into the cervical canal for concomitant measurement of diameters at 16 serial locations along the canal and the bag pressure. The bag was inflated to a maximum volume of 50ml. A three-fiber-families model including isotropic elastin-dominated matrix and anisotropic collagen was introduced to describe the mechanical behavior of the cervical canal. The unknown geometric and mechanical parameters were calculated on the basis of the mid-cervical diameters and the intraluminal pressures during the inflation. RESULTS: The wall thickness in the unloaded state (zero pressure applied) and mechanical properties of the matrix material (c) and collagens (c1, c2) were estimated with good fits of the calculated intraluminal pressures to the FLIP recordings during the cervical canal distension. No significant difference in the wall thickness was found between the early- and term-pregnant women (10.3±0.8mm vs. 11.7±2.2mm, p=0.30). The cervical matrix material and the collagen in the early-pregnant women were much stiffer than that in the term-pregnant women (p<0.05). CONCLUSIONS: The cervical mechanical properties can be obtained from recorded pressure and diameter data in vivo via the established mechanical model. Matrix material and collagens of the cervix wall were remodeled during pregnancy. The mechanical model can be applied to other tubular visceral organs where concomitant measures of pressure and diameter can be obtained for better understanding diseases and their evolution or treatment.

  10. Endometrial cancer with cervical extension mimicking dual concordant endometrial and cervical malignancy by F18 FDG PET and MRI

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Seok Nam [Kwandong Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-09-15

    A 35 year old woman with endometrial cancer and cervical extension underwent F18 FDG PET CT and MRI studies after resection of a cervical mass presumed to be cervical myoma. The patient underwent cervical myomectomy and the histopathologic report revealed poorly differentiated invasive carcinoma. Cervical cancer was ruled out because the patient had no history of sexual intercourse and was negative for human papilloma virus infection. The patient underwent radical hysterectomy, bilateral salpingo oophorectomy, pelvic and para aortic lymph node dissection, and multiple biopsies. F18 FDG PET CT showed intense FDG uptake along the cervix wall. T2 weighted MRI also revealed a mass lesion with high SI involving the anterior and posterior lips of the uterine cervix. Another area of focal increased uptake above the endometrial lesion in the left pelvic cavity was observed on PET CT and MRI, possibly due to a functioning ovary. PET CT and MRI were interpreted as showing a dual concordant malignant lesion due to separated FDG uptakes and high SI without any connection between the cervical and endometrial lesions. F18 FDG PET CT showed intense FDG uptake along the endometrium. Given the patient's history and the fact that she was not menstruating at the time of imaging, this intense uptake was interpreted as another pathologic lesion, suggesting dual primary lesions. A suspected heterogeneous mass lesion along the endometrium suggesting concordant endometrial cancer was found on MRI. Endometrial cancer with cervical extension is sometimes difficult to differentiate from primary cervical cancer. The final histopathologic report showed poorly differentiated endometrial adenocarcinoma with cervical extension, although the FDG PET CT and MRI findings were suggestive of concordant cervical and endometrial cancer. Although histopathologic confirmation is necessary for final diagnosis, MRI and FDG PET CT studies may aid in the differential diagnosis. A metastatic cervical mass from endometrial cancer clinically presenting as cervical myoma is rare. This case suggests that poorly differentiated endometrial cancer may extend into the cervix, presenting as cervical myoma, and the possibility of a metastatic mass should be considered in the differential diagnosis when dealing with cervical myoma.

  11. Endometrial cancer with cervical extension mimicking dual concordant endometrial and cervical malignancy by F18 FDG PET and MRI

    International Nuclear Information System (INIS)

    A 35 year old woman with endometrial cancer and cervical extension underwent F18 FDG PET CT and MRI studies after resection of a cervical mass presumed to be cervical myoma. The patient underwent cervical myomectomy and the histopathologic report revealed poorly differentiated invasive carcinoma. Cervical cancer was ruled out because the patient had no history of sexual intercourse and was negative for human papilloma virus infection. The patient underwent radical hysterectomy, bilateral salpingo oophorectomy, pelvic and para aortic lymph node dissection, and multiple biopsies. F18 FDG PET CT showed intense FDG uptake along the cervix wall. T2 weighted MRI also revealed a mass lesion with high SI involving the anterior and posterior lips of the uterine cervix. Another area of focal increased uptake above the endometrial lesion in the left pelvic cavity was observed on PET CT and MRI, possibly due to a functioning ovary. PET CT and MRI were interpreted as showing a dual concordant malignant lesion due to separated FDG uptakes and high SI without any connection between the cervical and endometrial lesions. F18 FDG PET CT showed intense FDG uptake along the endometrium. Given the patient's history and the fact that she was not menstruating at the time of imaging, this intense uptake was interpreted as another pathologic lesion, suggesting dual primary lesions. A suspected heterogeneous mass lesion along the endometrium suggesting concordant endometrial cancer was found on MRI. Endometrial cancer with cervical extension is sometimes difficult to differentiate from primary cervical cancer. The final histopathologic report showed poorly differentiated endometrial adenocarcinoma with cervical extension, although the FDG PET CT and MRI findings were suggestive of concordant cervical and endometrial cancer. Although histopathologic confirmation is necessary for final diagnosis, MRI and FDG PET CT studies may aid in the differential diagnosis. A metastatic cervical mass from endometrial cancer clinically presenting as cervical myoma is rare. This case suggests that poorly differentiated endometrial cancer may extend into the cervix, presenting as cervical myoma, and the possibility of a metastatic mass should be considered in the differential diagnosis when dealing with cervical myoma

  12. Use of an Intubating Stylet as a Guide to Complete Uterine Curettage Complicated by Uterine Perforation

    OpenAIRE

    Baum, Jonathan D; Douglas J. Sherlock; Atkinson, Andrew L.

    2013-01-01

    Completion of uterine curettage may be challenging following uterine perforation even under sonographic and laparoscopic monitoring. This report illustrates the use of a flexible intubating stylet as a guide to place the suction curette into the uterine cavity when sonography and laparoscopy alone are not successful. Use of a malleable instrument such as an intubating stylet as a guide should be considered an option when insertion of the suction curette into the uterine cavity is complicated ...

  13. Potassium channels and uterine function

    OpenAIRE

    Brainard, Adam M.; Korovkina, Victoria P.; England, Sarah K

    2007-01-01

    Ion channels are effector proteins that mediate uterine excitability throughout gestation. This review will focus primarily on the role of potassium channels in regulating myometrial tone in pregnancy and labor contractions. During gestation, potassium channels maintain the uterus in a state of quiescence by contributing to the resting membrane potential and counteracting contractile stimuli. This review summarizes the current knowledge about the significance of the potassium channels in main...

  14. Second-Trimester Uterine Rupture: Lessons Learnt

    OpenAIRE

    F. ABDULWAHAB, Dalia; ISMAIL, Hamizah; NUSEE, Zalina

    2014-01-01

    Uterine rupture is a rare life-threatening complication. It mainly occurs in the third trimester of pregnancy and is rarely seen during the first or second trimesters. Our centre experienced three important cases of uterine rupture. First case: spontaneous uterine rupture at 14 weeks of pregnancy, which was diagnosed at autopsy. It was misled by the ultrasound finding of an intrauterine pregnancy, and searching for other non-gynaecological causes delayed the urgent obstetric surgical manageme...

  15. True incidence of uterine adenomatoid tumors

    OpenAIRE

    Nakayama, Hirofumi; TERAMOTO, HIDEKI; TERAMOTO, MITSUE

    2013-01-01

    Uterine adenomatoid tumors (UATs) are benign tumors of the uterine serosa and myometrium that originate from the mesothelium and forming gland-like structures. This study was conducted in order to determine the true incidence of UATs, which are usually an incidental finding during uterine surgery performed for other causes. UATs may resemble pre-existing vessels and lymphatic ducts, as well as metastatic adenocarcinomas. A total of 199 consecutive surgical operations (134 hysterectomies and 6...

  16. Review literature on uterine carcinosarcoma.

    Science.gov (United States)

    Singh, Rajendra

    2014-01-01

    Carcinosarcoma of the uterus is a rare gynaecological neoplasm, which is also known as malignant mixed mesodermal tumor. Traditionally this tumour has been regarded as a subtype of uterine sarcoma, and its origin remains controversial. The exact nature and prognosis was not clear in the past. It is believed that uterine carcinosarcoma have a Mullerian duct origin and have a capacity to differentiate into various mesenchymal and epithelial components. Regarding the histogensis, various theories have been given; of which 'conversion theory' was broadly accepted. Carcinosarcoma are mostly of monoclonal origin with the carcinomatous component being the driving force. This type of tumor is broadly divided into two groups, homologous and heterologous, depending on the characteristics of the stroma or mesenchymal components of endometrial tissue. It is more frequent in black women and postmenopausal women. Radiation is a possible etiological factor but the exact etiology is not known yet. However, tamoxifen may induce carcinogenesis in some patients. Its clinical feature is very similar to endometrial carcinoma i.e. postmenopausal vaginal bleeding, have a very aggressive behavior and a poor prognosis. This pelvic malignancy is treated by multimodality therapy including surgery, chemotherapy and radiotherapy. Here we are reviewing old concepts about the disease and modern understandings of the origin, classification, pathogenesis and recent advances in the treatment of the uterine carcinosarcoma. PMID:25313723

  17. Review literature on uterine carcinosarcoma

    Directory of Open Access Journals (Sweden)

    Rajendra Singh

    2014-01-01

    Full Text Available Carcinosarcoma of the uterus is a rare gynaecological neoplasm, which is also known as malignant mixed mesodermal tumor. Traditionally this tumour has been regarded as a subtype of uterine sarcoma, and its origin remains controversial. The exact nature and prognosis was not clear in the past. It is believed that uterine carcinosarcoma have a Mullerian duct origin and have a capacity to differentiate into various mesenchymal and epithelial components. Regarding the histogensis, various theories have been given; of which ?conversion theory? was broadly accepted. Carcinosarcoma are mostly of monoclonal origin with the carcinomatous component being the driving force. This type of tumor is broadly divided into two groups, homologous and heterologous, depending on the characteristics of the stroma or mesenchymal components of endometrial tissue. It is more frequent in black women and postmenopausal women. Radiation is a possible etiological factor but the exact etiology is not known yet. However, tamoxifen may induce carcinogenesis in some patients. Its clinical feature is very similar to endometrial carcinoma i.e. postmenopausal vaginal bleeding, have a very aggressive behavior and a poor prognosis. This pelvic malignancy is treated by multimodality therapy including surgery, chemotherapy and radiotherapy. Here we are reviewing old concepts about the disease and modern understandings of the origin, classification, pathogenesis and recent advances in the treatment of the uterine carcinosarcoma.

  18. A CASE REPORT ON UTERINE AV MALFORMATION IN LOWER UTERINE SEGMENT PLACENTAL IMPLANTATION

    Directory of Open Access Journals (Sweden)

    Hima

    2014-02-01

    Full Text Available Uterine Arterio - venous malformations (AVM are rare and potentially life threatening condition. AV malformations may be congenital or acquired. We report a case of acquired uterine AV malformation at the placental implantation site in the lower uterine segment which complicated the diagnosis

  19. [Chronic renal failure secondary to uterine prolapse].

    Science.gov (United States)

    Peces, R; Canora, J; Venegas, J L

    2005-01-01

    Acute and chronic renal failure secondary to bilateral severe hydroureteronephrosis is a rare sequela of uterine prolapse. We report a case of neglected complete uterine prolapse in a 72-year-old patient resulting in bilateral hydroureter, hydronephrosis, and chronic renal failure. In an attempt to diminish the ureteral obstruction a vaginal pessary was used to reduce the uterine prolapse. Finally, surgical repair of prolapse by means of a vaginal hysterectomy was performed. In conclusion, all patients presenting with complete uterine prolapse should be screened to exclude urinary tract obstruction. If present, obstructive uropathy should be relieved by the reduction or repair of the prolapse before irreversible renal damage occurs. PMID:15912657

  20. Early second trimester uterine scar rupture

    OpenAIRE

    Bharatnur, Sunanda; Hebbar, Shripad; G, Shyamala

    2013-01-01

    Spontaneous uterine scar rupture can be lethal in pregnant women. A spontaneous uterine scar rupture in the early mid-trimester is rare and difficult to diagnose. This is a case of a 30-year-old woman (G2P1L1) at 19?weeks of gestation and having undergone a previous caesarean section presented with acute abdomen in shock. Laparotomy revealed a uterine scar rupture, which was resutured after evacuation of products of conception. This case merits that the uterine rupture should be considered as...

  1. [Uterine rupture: report of 41 cases].

    Science.gov (United States)

    Chennoufi, Mohamed Badis; Ben Temime, Riadh; Chelli, Dalenda; Ben Romdhane, Boutheina; Khemiri, Bechir; Maghrebi, Hayen; Sfar, Ezzeddine; Chelli, Hela

    2002-01-01

    To establish the epidemiological profile, of patients who presented a uterine rupture, as well as the obstetrical follow up, the neonatal outcome and the prognosis factors. A retrospective study of 41 cases of uterine rupture treated in the maternity center of Tunis during a 5-year period. The frequency of uterine rupture was 1.38%@1000 of births. Rupture in scarred uterus was found in 58.5% of the cases against 41.5% in sain uterus. Three risk factors were statistically significant in our series: cesarian section, multiparity and high fetal weight. Uterine rupture is a medico-surgical emergency causing materno-fetal morbidity and mortality. PMID:12071046

  2. Pallidal deep brain stimulation in patients with cervical dystonia and severe cervical dyskinesias with cervical myelopathy

    OpenAIRE

    Krauss, J.; Loher, T; Pohle, T; Weber, S.; Taub, E; Barlocher, C; BURGUNDER, J.

    2002-01-01

    Objectives: Surgical treatment of complex cervical dystonia and of cervical dyskinesias associated with cervical myelopathy is challenging. In this prospective study, the long term effect of chronic pallidal stimulation in cervical dystonia and on combining the technique with spinal surgery in patients with severe cervical dyskinesias and secondary cervical myelopathy is described.

  3. Prevent Cervical Cancer

    Science.gov (United States)

    ... professional printing [PDF-1.5MB] Cancer Home “Prevent Cervical Cancer” Infographic Language: English Español (Spanish) Recommend on Facebook Tweet Share Compartir Prevent Cervical Cancer with the Right Test at the Right Time ...

  4. Smoking and Cervical Cancer

    Science.gov (United States)

    Smoking and Cervical Cancer If you smoke, you have an increased chance of developing precancerous lesions of ... increase in the chance of developing cervical cancer. Smoking greatly increases your risk for dysplasia and cancer ...

  5. Stages of Cervical Cancer

    Science.gov (United States)

    ... Childhood Treatment . Human papillomavirus (HPV) infection is the major risk factor for cervical cancer. Anything that increases ... to collect cells or tissue from the cervical canal using a curette (spoon-shaped instrument). Tissue samples ...

  6. Alterações radiográficas de coluna cervical em artrite reumatoide / Radiographic changes of cervical spine in rheumatoid arthritis

    Scientific Electronic Library Online (English)

    Juan Marcelo Fernandez, Alcala; Diogo, Douat; Diogo Lago, Pinheiro; Douglas Jun, Kamei; Fábio Raimundo M dos, Santos; Marilia B, Silva; Thelma L, Skare.

    2013-10-01

    Full Text Available INTRODUÇÃO: O envolvimento da coluna cervical é comum na artrite reumatoide (AR). OBJETIVO: Estudar a prevalência das alterações radiológicas de coluna cervical em pacientes com AR e sua associação com perfil clinico e sorológico da doença. MÉTODOS: Analisaram-se as radiografias de coluna cervical e [...] m perfil neutro hiperextensão, hiperflexão e transoral de 80 pacientes com AR para presença de subluxação atlanto-axial (LAA), invaginação basilar (IB) e instabilidade subaxial (ISA). Dados de perfil demográfico, clínico (nódulos, pneumonite intersticial, síndrome Sjögren secundária, uso de medicamentos etc.) e sorológico (FR, anti-CCP e FAN) foram obtidos por revisão de prontuários. RESULTADOS: Havia alguma alteração de eixo de coluna cervical em 26/80 (32,5%); em 12/80 (15%) havia LAA; em 6/80(7,5%) existia IB; em 13/80 (16,2%) existia ISA. Erosões em odontoide foram vistas 16/80 (20,0%). As alterações do eixo cervical estavam associadas com idade de início da doença e duração da mesma (P = 0,03 e 0,02, respectivamente). Não se encontrou associação das alterações em coluna cervical com raça, gênero, nódulos, pneumonite intersticial, Sjögren secundário, FR, FAN ou anti-CCP. Pacientes com alterações do eixo cervical apresentavam mais erosões de odontoide (P = 0,03). CONCLUSÕES: Alterações radiológicas em eixo de coluna cervical são comuns e aparecem mais frequentemente em indivíduos com diagnóstico mais precoce de AR e maior tempo de doença. Abstract in english INTRODUCTION: The involvement of the cervical spine is a common feature of rheumatoid arthritis (RA). OBJECTIVE: To study the prevalence of radiographic changes of the cervical spine in patients with RA and their association with clinical and serological profiles of the disease. METHODS: We analysed [...] lateral (neutral position, hyperextension, hyperflexion) and transoral views of cervical spine radiographs from 80 individuals with RA to investigate the presence of atlanto-axial subluxation (AAS), basilar invagination (BI), and subaxial instability (SAI). Demographic, clinical (nodules, interstitial pneumonitis, secondary Sjögren's syndrome, medications etc.), and serologic (rheumatoid factor - RF, cyclic citrullinated peptide antibody - anti-CCP, and antinuclear factor - ANF) data were obtained from the clinical records. RESULTS: Cervical spine misalignments were identified in 26/80 (32.5%) participants; AAS occurred in 12/80 (15%) participants, BI in 6/80 (7.5%), and SAI in 13/80 (32.5%). Odontoid erosions were identified in 16/80 (20.0%) participants. Cervical spine misalignment exhibited associations with age at onset and disease duration (P = 0.03 and 0.02, respectively). No associations were identified between the cervical spine changes and the participants' ethnicity or gender, presence of nodules, interstitial pneumonitis, secondary Sjögren's syndrome, RF, ANF, or anti-CCP. The participants with cervical spine misalignment exhibited higher frequencies of odontoid erosion (P = 0.03). CONCLUSIONS: Cervical spine misalignment was a common radiographic finding and occurred more frequently in participants with earlier onset and longer length of RA.

  7. Induced soft tissue sarcomas following radiation treatment for uterine carcinomas

    International Nuclear Information System (INIS)

    Twenty-two cases of sarcomas arising from irradiated soft tissues were observed in 531 patients operated on for soft tissue sarcomas over 38 years in our Department. Eleven women were initially irradiated for cervical cancer (ce-ca), two for endometrial cancers. The remaining nine patients were irradiated for other lesions, malignant or benign. The median interval between the radiation for uterine cancer and the outcome of clinical symptoms of a sarcoma was 18 years. Sarcomas more frequently arose in the posterior fields (buttock or sacral region in nine patients) than in the anterior (pubis, hypogastrium-four patients). The infiltration of skin was almost always present (10/13), in seven cases with an ulceration (7/13). Histologically, four hemangiosarcomas, four fibrosarcomas, three malignant fibrous histiocytomas and two neurofibrosarcomas were found. The irradiation administered to ce-ca patients consisted of radium (22.0 mcd to 58.0 mcd) and an external radiation from X-ray units (except in one case) from two pairs of two anterior and posterior fields, with skin doses of 3200 cGy to 4200 cGy directly on one field plus several hundreds cGy from the opposite field. Three-year overall survival rate was low (30%) similar to that observed in patients with primary high-grade (G-3) sarcomas. We observed more cases subjected to radiotherapy for cervical cancer than might be expected. (author)

  8. Experimental platform for intra-uterine needle placement procedures

    Science.gov (United States)

    Madjidi, Yashar; Haidegger, Tamás.; Ptacek, Wolfgang; Berger, Daniel; Kirisits, Christian; Kronreif, Gernot; Fichtinger, Gabor

    2013-03-01

    A framework has been investigated to enable a variety of comparative studies in the context of needle-based gynaecological brachytherapy. Our aim was to create an anthropomorphic phantom-based platform. The three main elements of the platform are the organ model, needle guide, and needle drive. These have been studied and designed to replicate the close environment of brachytherapy treatment for cervical cancer. Key features were created with the help of collaborating interventional radio-oncologists and the observations made in the operating room. A phantom box, representing the uterus model, has been developed considering available surgical analogies and operational limitations, such as organs at risk. A modular phantom-based platform has been designed and prototyped with the capability of providing various boundary conditions for the target organ. By mimicking the female pelvic floor, this framework has been used to compare a variety of needle insertion techniques and configurations for cervical and uterine interventions. The results showed that the proposed methodology is useful for the investigation of quantifiable experiments in the intraabdominal and pelvic regions.

  9. Cervical Cancer Screening

    Science.gov (United States)

    ... women. Human papillomavirus (HPV) infection is the major risk factor for cervical cancer. Although most women with cervical cancer have the ... are at increased risk for HPV infections. Other risk factors for cervical cancer include: Giving birth to many children. Smoking cigarettes. ...

  10. Established, emerging and future applications of FDG-PET/CT in the uterine cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kitajima, K., E-mail: kitajima@med.kobe-u.ac.j [PET Diagnosis, Institute of Biomedical Research and Innovation, Kobe (Japan); Murakami, K. [Division of Nuclear Medicine, Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo (Japan); Kaji, Y. [Radiology, Dokkyo University School of Medicine, Mibu (Japan); Sakamoto, S. [PET center, Dokkyo Medical University Hospital, Mibu (Japan); Sugimura, K. [Department of Radiology, Kobe University Graduate School of Medicine, Kobe (Japan)

    2011-04-15

    Integrated positron emission tomography/computed tomography (PET/CT) with 2-[{sup 18}F]fluoro-2-deoxy-D-glucose (FDG) is a useful technique to acquire both glucose metabolic and anatomic imaging data using a single device in a single diagnostic session and has opened a new field in clinical oncologic imaging. FDG-PET/CT has been used successfully for the staging, optimization of treatment, re-staging, therapy monitoring, and prognostic prediction of uterine cervical cancer and endometrial cancer as well as various malignant tumours. The present review discusses the current role of FDG-PET/CT in the management of uterine cancer, discussing its usefulness and limitations in the imaging of these patients.

  11. Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer

    Science.gov (United States)

    2016-03-14

    Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Small Cell Carcinoma; Cervical Squamous Cell Carcinoma; Recurrent Cervical Carcinoma; Stage III Cervical Cancer; Stage IVA Cervical Cancer; Stage IVB Cervical Cancer

  12. Ritidoplastia cervical reversa / Reverse cervical rhytidectomy

    Scientific Electronic Library Online (English)

    Aristoteles, Bersou Junior; Guilherme, Bersou.

    2010-09-01

    Full Text Available Rejuvenescimento da região cervical anterior por técnica usualmente utilizada nas ritidoplastias é indicado para casos de pacientes com problemas de flacidez, associada ou não com bandas de platisma, com ou sem adiposidade localizada ou mesmo generalizada. Nos casos em que estes aspectos estão local [...] izados no terço cervical inferior e, em particular, junto à fúrcula esternal e clavículas, observamos a possibilidade de realizar a ritidoplastia cervical reversa. Abstract in english Neck rejuvenation by technique usually used in rhytidectomy is recommended for cases of patients suffering from sagging either or not associated with platisma bands with or without generalized adiposity. In cases which these areas are located in the lower cervical, and particularly near the sternal [...] notch and clavicles, we observed the possibility of reverse cervical rhytedectomy.

  13. Ritidoplastia cervical reversa Reverse cervical rhytidectomy

    Directory of Open Access Journals (Sweden)

    Aristoteles Bersou Junior

    2010-09-01

    Full Text Available Rejuvenescimento da região cervical anterior por técnica usualmente utilizada nas ritidoplastias é indicado para casos de pacientes com problemas de flacidez, associada ou não com bandas de platisma, com ou sem adiposidade localizada ou mesmo generalizada. Nos casos em que estes aspectos estão localizados no terço cervical inferior e, em particular, junto à fúrcula esternal e clavículas, observamos a possibilidade de realizar a ritidoplastia cervical reversa.Neck rejuvenation by technique usually used in rhytidectomy is recommended for cases of patients suffering from sagging either or not associated with platisma bands with or without generalized adiposity. In cases which these areas are located in the lower cervical, and particularly near the sternal notch and clavicles, we observed the possibility of reverse cervical rhytedectomy.

  14. Uterine cervix cancer and pregnancy

    International Nuclear Information System (INIS)

    Objective: Describe a pathology with a high incidence in our means, in association with pregnancy in this case, graphically report they type of cervical malignancy, clinical manifestations, diagnose and treatment according to stage. Clinical case: We present a young patient with cervical pathology (endofitic bleeding lesion) diagnosed during the first trimester of pregnancy, with complete pregnancy, that consult because of genital bleeding, founding an endofitic lesion by colposcopic exam and which biopsy and pap test reported a scamous cell carcinoma, image diagnostic procedures reveal a 6 month product, that after surgical ending of pregnancy, wa treated by radical hysterectomy. Conclusions: It is important to recognize that in cervical pathology; cervical cancer during pregnancy is a great challenge for the specialist, the diagnostic evaluation that includes biopsies, must be realized in the same way, except from the endocervical canal. The treatment of choice for women is early stages of pregnancy is radical hysterectomy, during the last half of pregnancy it is possible to wait the viability of the product planning the childbirth surgically as soon as possible. (The author)

  15. Selective artery embolization for treatment of uterine myoma

    International Nuclear Information System (INIS)

    Objective: To assess the clinical effects of selective embolization of uterine arteries in the treatment of uterine myomata. Methods: 15 cases with symptomatic uterine myomata were treated by Seldinger's selective uterine arteries embolization. After a percutaneous femoral arterial puncture, an artery catheter was selectively inserted into bilateral uterine arteries. The insertion silk of fragments and gel form were introduced through catheter to occlude the blood supply of myoma. Results: Arteriography showed that most uterine myomata were supplied by bilateral uterine arteries. When both uterine arteries were embolized, the blood supply of uterine myoma could be occluded. With a mean follow-up of 6 months the menorrhagia and menstrual cycles returned to normal and, pain resolved. Conclusions: Selective uterine artery embolization is a new method for treatment of uterine myomata with less trauma

  16. Recurrent Corneal Erosion

    Science.gov (United States)

    ... rashes clinical tools newsletter | contact Share | Recurrent Corneal Erosion Information for adults A A A The irregularity ... patient being the critical difference. Overview Recurrent corneal erosion is the recurrent breakdown of the outermost layer ( ...

  17. Acute Renal Failure after Uterine Artery Embolization

    International Nuclear Information System (INIS)

    Renal failure is a potential complication of any endovascular procedure using iodinated contrast, including uterine artery embolization (UAE). In this report we present a case of acute renal failure (ARF) following UAE performed as a treatment for uterine fibroids. The likely causes of ARF in this patient are explored and the possible etiologies of renal failure in patients undergoing UAE are reviewed

  18. Uterine prolapse in 2 dromedary camels.

    OpenAIRE

    Gutierrez, C; Corbera, J. A.; Morales, I; M Morales; Navarro, R

    2001-01-01

    Two cases of uterine prolapse in dromedary camels in a herd with concomitant cases of white muscle disease are described. Serum selenium and glutathione peroxidase in whole blood were investigated in both patients and showed statistical difference compared with a control group. Results suggest that selenium deficiency could promote uterine prolapse in dromedary camels.

  19. Uterine prolapse in 2 dromedary camels.

    Science.gov (United States)

    Gutierrez, C; Corbera, J A; Morales, I; Morales, M; Navarro, R

    2001-10-01

    Two cases of uterine prolapse in dromedary camels in a herd with concomitant cases of white muscle disease are described. Serum selenium and glutathione peroxidase in whole blood were investigated in both patients and showed statistical difference compared with a control group. Results suggest that selenium deficiency could promote uterine prolapse in dromedary camels. PMID:11665430

  20. Operative and Conservative Treatment of Uterine Sarcomas.

    Science.gov (United States)

    Harter, P; El-Khalfaoui, K; Heitz, F; du Bois, A

    2014-03-01

    Uterine sarcomas are rare, aggressive mesenchymal tumours with a relatively poor prognosis. The term comprises various histological subtypes, such as leiomyosarcoma, endometrial stromal sarcomas as well as undifferentiated uterine sarcomas, which require different operative and systemic/radiation therapy strategies accordingly. The evidence on operative, adjuvant and palliative treatment currently available is presented here. PMID:24882876

  1. Seismicity and Erosion

    OpenAIRE

    Hovius, Niels; Meunier, Patrick; Dadson, Simon

    2008-01-01

    Earthquakes build topography but also drive erosion. Erosion, in turn, may control seismicity. Nowhere is this two way feedback more evident than in Taiwan. There, patterns of erosion and seismicity are demonstrably correlated, over decades and also at the scale of individual, large earthquakes. At the scale of the mountain belt, the pattern of erosion shares elements with the distribution of cumulative seismic mo- ment, and the relative importance of typhoons. Are these controls independent,...

  2. Erosion-corrosion

    International Nuclear Information System (INIS)

    A literature study on erosion-corrosion of pipings in the nuclear industry was performed. Occurred incidents are reviewed, and the mechanism driving the erosion-corrosion is described. Factors that influence the effect in negative or positive direction are treated, as well as programs for control and inspection. Finally, examples of failures from databases on erosion-corrosion are given in an attachment

  3. Early second trimester uterine scar rupture.

    Science.gov (United States)

    Bharatnur, Sunanda; Hebbar, Shripad; Shyamala, G

    2013-01-01

    Spontaneous uterine scar rupture can be lethal in pregnant women. A spontaneous uterine scar rupture in the early mid-trimester is rare and difficult to diagnose. This is a case of a 30-year-old woman (G2P1L1) at 19 weeks of gestation and having undergone a previous caesarean section presented with acute abdomen in shock. Laparotomy revealed a uterine scar rupture, which was resutured after evacuation of products of conception. This case merits that the uterine rupture should be considered as a differential diagnosis in pregnant women presenting with acute abdomen. In this case, although there was uterine rupture in the second trimester and a complete placental separation, fetus was alive which is quite unusual in patients presenting with rupture uterus. PMID:24326433

  4. ADXS11-001 High Dose HPV+ Cervical Cancer

    Science.gov (United States)

    2016-03-02

    Effects of Immunotherapy; Metastatic/Recurrent Cervical Cancer; Cervical Adenocarcinoma; Cervical Adenosquamous Cell Carcinoma; Cervical Squamous Cell Carcinoma; Cervical Small Cell Carcinoma; Stage III Cervical Cancer; Stage IVA Cervical Cancer; Stage IVB Cervical Cancer

  5. Correlation of Traditional Point a With Anatomic Location of Uterine Artery and Ureter in Cancer of the Uterine Cervix

    International Nuclear Information System (INIS)

    Purpose: Point A, used for dose specification for intracavitary brachytherapy for cervical cancer, is the point at which the uterine artery and ureter cross. This study assessed compatibility of commonly used traditional point A (TPA) and actual anatomic point A (APA). Methods and Materials: We visualized and placed radiopaque clips at the APA during pelvic and paraaortic lymphadenectomy in 11 patients with cervical carcinoma. Orthogonal and oblique radiographs were obtained after insertion of brachytherapy applicators. We measured the distance between the TPA and APA and estimated the brachytherapy dose to each of the two points. Results: A total of 64 brachytherapy treatments were performed. The mean distances between the TPA and APA were 5.2 ± 1.0 cm on the right and 5.4 ± 1.1 cm on the left. The estimated brachytherapy doses delivered to the APA as a percentage of the presumed 500-cGy fraction size to the TPA were 35.2% (176.6 ± 59.0 cGy) on the right and 30.0% (150.2 ± 42.9 cGy) on the left. The marked discrepancy in the position of the two points was not related to individual kinetic variations during brachytherapy treatment, tumor size, or bladder filling. Conclusions: The conventional TPA does not provide an accurate estimate of the APA determined during lymphadenectomy, indicating a need to reevaluate the current practice for determining the brachytherapy prescription for cervical cancer. ( (ClinicalTrials.gov) Identifier, NCT00319462)

  6. Uncommon sarcomas of the uterine cervix: a review of selected entities

    Directory of Open Access Journals (Sweden)

    Fadare Oluwole

    2006-09-01

    Full Text Available Abstract Sarcomas constitute less than 1% of all cervical malignancies. With over 150 reported cases, rhabdomyosarcomas represent the most commonly reported sarcoma at this location. In this report, a select group of the more uncommon sarcomas of the uterine cervix are reviewed, including all previously reported examples of leiomyosarcoma, liposarcoma, alveolar soft part sarcoma, Ewing sarcoma/primitive neuroectodermal tumor, undifferentiated endocervical sarcoma, and malignant peripheral nerve sheath tumor (MPNST. Emphasis is placed on any distinctive clinicopathologic features of these entities at this unusual location.

  7. Cervical stiffness evaluated in vivo by endoflip in pregnant women

    DEFF Research Database (Denmark)

    Hee, Lene; Sandager, Puk

    2014-01-01

    OBJECTIVE: To determine the stiffness of the pregnant uterine cervix in vivo. METHOD: Five women in early pregnancy and six women in late pregnancy were included. The EndoFlip is a 1-m-long probe with a 12-cm-long bag mounted on the tip. The tip of the probe was inserted into the cervical canal. Sensors spaced at 0.5-cm intervals along the probe were used to determine 16 serial cross-sectional areas of the bag. The diameter of the cervical canal could thereby be determined during inflation with up to 50 ml saline solution. Tissue stiffness was calculated from the geometric profiles and the pressure-strain elastic modulus (EP) at each sensor site. Three parts of the cervix were defined: the uterus-near part, the middle and the vaginal part. The EPmax was defined as the highest EP detected along the cervical canal. RESULTS: The EPmax was always found in the middle part of the cervix. The median EPmax was 243 kPa (IQR, 67-422 kPa) for the early pregnant women and 5 kPa (IQR, 4-15 kPa) for those at term. In theearly pregnant women the stiffness differed along the cervical length (p<0.05) whereas difference along the cervix was not found for late pregnant women. A positive correlation coefficient (Spearman's rho) was established between the EPs of the uterus-near and the middle part (0.84), between the vaginal and the middle part (0.81), and between the uterus-near and the vaginal part (0.85). CONCLUSION: This new method can estimate the stiffness along the cervical canal in vivo. This method may be useful in the clinical examination of the biomechanical properties of the uterine cervix.

  8. An overview on applications of optical spectroscopy in cervical cancers

    Directory of Open Access Journals (Sweden)

    Chilakapati Murali

    2008-01-01

    Full Text Available Despite advances in the treatment modalities, cervical cancers are one of the leading causes of cancer death among women. Pap smear and colposcopy are the existing screening methods and histopathology is the gold standard for diagnosis. However, these methods have been shown to be prone to reporting errors, which could be due to their subjective interpretation. Radiotherapy is the mainstay of treatment for the locally advanced stages of cervical cancers. The typical treatment regimen spans over 4 months, from the first fraction of radiation to clinical assessment of tumor response to radiotherapy. It is often noticed that due to intrinsic properties of tumors, patients with the same clinical stage and histological type respond differently to radiotherapy. Hence, there exists a need for the development of new methods for early diagnosis as well as for early prediction of tumor radioresponse. Optical spectroscopic methods have been shown to be potential alternatives for use in cancer diagnosis. In this review, we provide a brief background on the anatomy and histology of the uterine cervix and the etiology of cervical cancers; we briefly discuss the optical spectroscopic approach to cervical cancer diagnosis. A very brief discussion on radiation therapy and radiation resistance is also provided. We also share our experiences with the Raman spectroscopic methodologies in cervical cancer diagnosis as well as in the prediction of tumor radioresponse.

  9. Hidden bone erosions

    Directory of Open Access Journals (Sweden)

    F. Salaffi

    2011-09-01

    Full Text Available The aim of this pictorial essay was to demonstrate the diagnostic efficacy of high-resolution sonography in detecting bone erosions in a patient with rheumatoid arthritis. Standard X-Ray of the feet did not reveal clearly evident erosions. Ultrasonography was able to detect the presence of bone erosions of the metatarsal heads of both the first toes and of the V toe of the left foot. Because the appearance of bone erosions on radiographs of a patient with a recent onset arthritis indicates a poor prognosis, the possibility of demonstrating small hidden erosions at the level of the early targets of the disease is of relevant practical value.

  10. Management of disfunctional uterine bleeding

    Directory of Open Access Journals (Sweden)

    Bumin

    2011-03-01

    Full Text Available Dysfunctional uterine bleeding (DUB is defined as abnormal uterine bleeding in the absence of demonstrable structural or organic pathology. Bleeding occurs frequently or irregularly, lasts longer, or is heavier. DUB is the most common cause of abnormal vaginal bleeding during a woman's reproductive years and occurs most commonly at the beginning of the reproductive years in adolescent girls. The frequency is 20% in adolescent girls. DUB is diagnosed when all other possible causes of vaginal bleeding have been excluded such as bleeding disorders, pregnancy, medications, iatrogenic causes, genital tract pathology, malignancy, and systemic disease by appropriate investigations. Approximately 90% of DUB cases result from hypothalamic anovulation in adolescents during early puberty. The goal of therapy should be to arrest bleeding, replace lost iron to avoid anemia, and prevent future bleeding. Conjugated estrogen (Premarin 25 mg IV can be given every 4-6 hours until the bleeding stops for very heavy bleeding. After bleeding stops, low doses of the oral contraceptive may then be prescribed for at least 3 months to prevent the bleeding from recurring. Combination oral contraceptive pills with 35 mcg of ethinyl estradiol may be used or progesterone alone can be used to stabilize an immature endometrium until the bleeding stops for up to 7 days in patients with moderate bleeding. Gonadotropin-releasing hormone agonists may be helpful for short-term use when oral contraceptive pills are contradicated. (Turk Arch Ped 2011; 46 Suppl: 103-6

  11. Rainfall Erosivity in Europe

    DEFF Research Database (Denmark)

    Panagos, Panos; Ballabio, Cristiano; Borrelli, Pasquale; Meusburger, Katrin; Klik, Andreas; Rousseva, Svetlana; Tadic, Melita Percec; Michaelides, Silas; Hrabaliková, Michaela; Olsen, Preben; Aalto, Juha; Lakatos, Mónika; Rymszewicz, Anna; Dumitrescu, Alexandru; Begueria, Santiago; Alewell, Christine

    2015-01-01

    Rainfall is one the main drivers of soil erosion. The erosive force of rainfall is expressed as rainfall erosivity. Rainfall erosivity considers the rainfall amount and intensity, and is most commonly expressed as the Rfactor in the USLE model and its revised version, RUSLE. At national and...... continental levels, the scarce availability of data obliges soil erosion modellers to estimate this factor based on rainfall data with only low temporal resolution (daily, monthly, annual averages). The purpose of this study is to assess rainfall erosivity in Europe in the form of the RUSLE R-factor, based on....... Gaussian Process Regression (GPR) has been used to interpolate the R-factor station values to a European rainfall erosivity map at 1 km resolution. The covariates used for the R-factor interpolation were climatic data (total precipitation, seasonal precipitation, precipitation of driest/wettest months...

  12. Rheumatoid arthritis: Radiological changes in the cervical spine

    International Nuclear Information System (INIS)

    Objective was to describe the radiographic cervical spine changes in rheumatoid arthritis patients.Forty-nine patients (37 females and 12 males ) diagnosed with rheumatoid arthritis at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between June 1998 and December 2000, were studied for their radiographic cervical spine changes . Their mean age at disease onset was 41.4+ 13.4 years (range of 18-73)and mean duration of disease was 9.1+-6.28 years (range of 2-34). Their demographic data including rheumatoid factor status was obtained. Standard conventional radiographs cervical spine were obtained to study the cervical spine changes. Cervical radiographic changes were found in 34 patients (27 females and 7 males) 10 had subluxation (7 with atlanto-axial subluxation,2 with sub-axial subluxation,and one with lateral subluxation ). No vertical impaction was seen. Erosion of odontoid process was seen in one patient .All were rheumatoid seropositive Cervical spine changes in patients with rheumatoid arthritis are common, in particular subluxation in the upper cervical spine. Our study showed somewhat lesser prevalence of these changes. These were clinically correlated with disease duration, female sex, and rheumatoid factor, but were not clinically significant. (author)

  13. HER-2/neu expression in lesions of uterine cervix: Is it reliable and consistent?

    Directory of Open Access Journals (Sweden)

    Gupta Nidhi

    2009-10-01

    Full Text Available This study was conducted to evaluate the expression of HER-2/neu oncogene in the lesions of the uterine cervix and to determine its correlation with histological type of malignancy, grade and clinical stage of presentation. One hundred cervical specimens were included in this study. These comprised cases with diagnosis of benign epithelial lesions, squamous cell carcinoma, adenocarcinoma, carcinoma cervix with glandular differentiation and cervical intraepithelial neoplasia. HER-2/neu immunostaining was performed by streptovidin-biotin peroxidase method. Higher expression of HER-2/neu was noted in malignant lesions as compared to benign lesions. Intensity of staining also correlated with clinical stage of presentation, lymph node metastasis and presence of parametrial extension. The over-expression of HER-2 oncoprotein is associated with poor prognosis, metastatic potential and aggressive biological behavior.

  14. [Possibilities of the TruScreen for screening of precancer and cancer of the uterine cervix].

    Science.gov (United States)

    Zlatkov, V

    2009-01-01

    The classic approach of detection of pre-cancer and cancer of uterine cervix includes cytological examination, followed by colposcopy assessment of the detected cytological abnormalities. Real-time devices use in-vivo techniques for the measurement, computerized analysis and classifying of different types of cervical tissues. The aim of the present review is to present the technical characteristics and to discus the diagnostic possibilities of TruScreen-automated optical-electron system for cervical screening. The analysis of the presented in the literature diagnostic value of the method at different grades intraepithelial lesions shows that it has higher sensitivity (67-70%) and lower specificity (81%) in comparison to the Pap test with the following results (45-69% sensitivity and 95% specificity). This makes the method suitable for independent primary screening, as well as for adding the diagnostic assurance of the cytological method. PMID:20225497

  15. Efficacy of transcatheter uterine artery embolization for treating emergency hemorrhage obstetrics and gynecology

    International Nuclear Information System (INIS)

    Objective: To evaluate the efficacy of selective iliac artery embolization (TAE) or uterine artery embolization (UAE) for treatment of emergency hemorrhage in obstetrics and gynecology. Methods: Selective bilateral TAE or UAE were performed on 59 patients with acute cervical hemorrhage from postpartum hemorrhage (30), cervical cancer (16), endometrial cancer (8), and choriocarcinoma (5). Gelfoam particles were used in postpartum hemorrhage; chemotherapeutics and Iodipin suspension were used in malignancy. Results: Bleeding was stopped completely in all 59 patients with TAE or UAE procedure time of 30-50 minutes (mean: 42.17±4.78 minutes). There were no serious complications. Conclusion: TAE or UAE are effective for treating emergency hemorrhage in obstetrics and gynecology. (authors)

  16. Uterine transplantation: a promising surrogate to surrogacy?

    Science.gov (United States)

    Grynberg, Michael; Ayoubi, Jean-Marc; Bulletti, Carlo; Frydman, Rene; Fanchin, Renato

    2011-03-01

    Infertility due to the inability of the uterus to carry a pregnancy ranks among the most unresolved issues in reproductive medicine. It affects millions of women worldwide who have congenital or acquired uterine affections, often requiring hysterectomy, and potentially represents a considerable fraction of the general infertile population. Patients suffering from severe uterine infertility are currently compelled to go through gestational surrogacy or adoption; both approaches, unfortunately, deprive them of the maternal experience of pregnancy and birth. Uterine transplantation represents an outstanding, yet complex, perspective to alleviating definitive uterine infertility. In the past decades, a number of scientific experiments conducted both in animals and women, focusing on uterine transplantation, have led to promising results. Collectively, these findings undoubtedly constitute a sound basis to clinically apply uterine transplantation in the near future. This paper is, however, an overview not only of the extent and limitations of accumulated scientific knowledge on uterine transplantation, but also its ethical implications, in an effort to define the actual place of such an approach among the therapeutic arsenal for alleviating infertility. PMID:21401629

  17. Uterine artery embolization as a treatment option for uterine myomas.

    Science.gov (United States)

    Marshburn, Paul B; Matthews, Michelle L; Hurst, Bradley S

    2006-03-01

    Information is still being collected on the long-term clinical responses and appropriate patient selection for UAE. Prospective RCTs have not been performed to compare the clinical results from UAE with more conventional therapies for symptomatic uterine leiomyomata. At least three attempts at conducting such RCTs have been unsuccessful because of poor patient accrual that related to differing patient expectation and desires, clinical bias, insurance coverage, and the tendency that patients who have exhausted other treatment options may be disposed more favorably to less invasive treatments. Other comparative studies have serious limitations. For example, the retrospective study that compared outcomes after abdominal myomectomy with UAE suggested that patients who received UAE were more likely to require further invasive treatment by 3 years than were recipients of myomectomy. Lack of randomization introduced a selection bias because women in the group that underwent UAEwere older and were more likely to have had previous surgeries. A prospective study of "contemporaneous cohorts," which excluded patients who had sub-mucosal and pedunculated subserosal myomas, sought to compare quality of life measures and adverse events in patients who underwent UAE or hysterectomy. The investigators concluded that both treatments resulted in marked improvement in symptoms and quality of life scores, but complications were higher in the group that underwent hysterectomy over 1 year. In this study,however, a greater proportion of patients who underwent hysterectomy had improved pelvic pain scores. Furthermore, hysterectomy eliminates uterine bleeding and the risk for recurrence of myomas. Despite the lack of controlled studies that compared UAE with conventional surgery, and despite limited extended outcome data, UAE has gained rapid acceptance, primarily because the procedure preserves the uterus, is less invasive, and has less short-term morbidity than do most surgical options. The cost of UAE varies by region, but is comparable to the charges for hysterectomy and is less expensive than abdominal myomectomy. The evaluation before UAE may entail additional fees for diagnostic testing, such as MRI, to assess the uterine size and screen for adenomyosis. Other centers have recommended pretreatment ultrasonography, laparoscopy, hysteroscopy, endometrial biopsy, and biopsy of large fibroids to evaluate sarcoma. Generally,after UAE the recovery time and time lost from work are less; however, the potential need for subsequent surgery may be greater when compared with abdominal myomectomy. Any center that offers UAE should adhere to published clinical guidelines,maintain ongoing assessment of quality improvements measures, and observe strict criteria for obtaining procedural privileges. After McLucas advocated that gynecologists learn the skill to perform UAE for managing symptomatic myomas, the Society of Interventional Radiology responded with a precautionary commentary on the level of technical proficiency that is necessary to maintain optimum results from UAE. The complexity of pelvic arterial anatomy, the skill that is required to master modern coaxial microcatheters, and the hazards of significant patient radiation exposure were cited as reasons why sound training and demonstration of expertise be obtained before clinicians are credentialed to perform UAE.A collaboration between the gynecologist and the interventional radiologist is necessary to optimize the safety and efficacy of UAE. The primary candidates for this procedure include women who have symptomatic uterine fibroids who no longer desire fertility, but wish to avoid surgery or are poor surgical risks. The gynecologist is likely to be the primary initial consultant to patients who present with complaints of symptomatic myomas. Therefore, they must be familiar with the indications, exclusions, outcome expectations, and complications of UAE in their particular center. When hysterectomy is the only option, UAE should be considered. Appropriate diagnostic testing should ai

  18. Rapid, sensitive, type specific PCR detection of the E7 region of human papillomavirus type 16 and 18 from paraffin embedded sections of cervical carcinoma

    OpenAIRE

    Hamilton-Dutoit Steven; Lidang Marianne; Lesnikova Iana; Koch Jørn

    2010-01-01

    Abstract Human papillomavirus (HPV) infection, and in particularly infection with HPVs 16 and 18, is a central carcinogenic factor in the uterine cervix. We established and optimized a PCR assay for the detection and discrimination of HPV types 16 and 18 in archival formaldehyde fixed and paraffin embedded (FFPE) sections of cervical cancer. Tissue blocks from 35 cases of in situ or invasive cervical squamous cell carcinoma and surrogate FFPE sections containing the cell lines HeLa and SiHa w...

  19. IMOP: randomised placebo controlled trial of outpatient cervical ripening with isosorbide mononitrate (IMN) prior to induction of labour – clinical trial with analyses of efficacy, cost effectiveness and acceptability

    OpenAIRE

    Greer Ian; Reid Margaret; Petrou Stavros; Norrie John; Mackenzie Fiona; Bollapragada Shrikant; Osman Inass; Norman Jane E

    2006-01-01

    Abstract Background There is increasing interest in carrying out pre-induction cervical ripening on an outpatient basis. However, there are concerns about the use of prostaglandins, the agents commonly used in hospital settings for this indication, because prostaglandins induce uterine contractions that may lead to fetal hypoxia. Indeed, in a recent study we demonstrated abnormalities in 9% of fetal heart rate tracings performed following prostaglandin induced cervical ripening at term. In co...

  20. Rapid, sensitive, type specific PCR detection of the E7 region of human papillomavirus type 16 and 18 from paraffin embedded sections of cervical carcinoma

    DEFF Research Database (Denmark)

    Lesnikova, Iana; Lidang, Marianne; Hamilton-Dutoit, Stephen Jacques; Koch, Jørn

    2010-01-01

    ABSTRACT: Human papillomavirus (HPV) infection, and in particularly infection with HPVs 16 and 18 is a central carcinogenic factor in the uterine cervix. We established and optimized a PCR assay for the detection and discrimination of HPV types 16 and 18 in archival formaldehyde fixed and paraffin embedded (FFPE) sections of cervical cancer. Tissue blocks from 35 cases of in situ or invasive cervical squamouscell carcinoma and surrogate FFPE sections containing the cell lines HeLa and SiHa were ...

  1. Diffuse uterine leiomyomatosis in a child

    Energy Technology Data Exchange (ETDEWEB)

    Pai, Deepa; Coletti, Monette C.; Ladino-Torres, Maria; Caoili, Elaine [University of Michigan Health System, Department of Radiology, Section of Pediatric Radiology, Ann Arbor, MI (United States); Elkins, Matthew [University of Michigan Health System, Department of Pathology, Ann Arbor, MI (United States)

    2012-01-15

    Leiomyomas are the most common benign uterine tumor; however, this entity is relatively uncommon in the pediatric population. Although leiomyomas most commonly present as solitary uterine masses, unusual patterns of growth have been described including diffuse leiomyomatosis. In this condition, the myometrium of the uterus is symmetrically expanded by innumerable confluent leiomyomas; this pattern of growth is quite uncommon and has never been reported in a pediatric patient. This case report illustrates the imaging appearance of diffuse uterine leiomyomatosis in an otherwise healthy 16-year-old girl. (orig.)

  2. Diffuse uterine leiomyomatosis in a child

    International Nuclear Information System (INIS)

    Leiomyomas are the most common benign uterine tumor; however, this entity is relatively uncommon in the pediatric population. Although leiomyomas most commonly present as solitary uterine masses, unusual patterns of growth have been described including diffuse leiomyomatosis. In this condition, the myometrium of the uterus is symmetrically expanded by innumerable confluent leiomyomas; this pattern of growth is quite uncommon and has never been reported in a pediatric patient. This case report illustrates the imaging appearance of diffuse uterine leiomyomatosis in an otherwise healthy 16-year-old girl. (orig.)

  3. Cervical Total Disc Arthroplasty

    OpenAIRE

    Basho, Rahul; Hood, Kenneth A.

    2012-01-01

    Symptomatic adjacent segment degeneration of the cervical spine remains problematic for patients and surgeons alike. Despite advances in surgical techniques and instrumentation, the solution remains elusive. Spurred by the success of total joint arthroplasty in hips and knees, surgeons and industry have turned to motion preservation devices in the cervical spine. By preserving motion at the diseased level, the hope is that adjacent segment degeneration can be prevented. Multiple cervical disc...

  4. Adjuvant postoperative radiation therapy for carcinoma of the uterine cervix

    International Nuclear Information System (INIS)

    This study was undertaken to evaluate the efficacy of postoperative radiotherapy, and to investigate the prognostic factors for FIGO stages IB-IIB cervical cancer patients who were treated with simple hysterectomy, or who had high-risk factors following radical hysterectomy and pelvic lymph node dissection. Between March 1986 and December 1998, 58 patients, with FIGO stages IB-IIB cervical cancer were included in this study, The indications for postoperative radiation therapy were based on the pathological findings, including lymph node metastasis, positive surgical margin, parametrial extension, Iymphovascular invasion, invasion of more than half the cervical stroma, uterine extension and the incidental finding of cervix cancer following simple hysterectomy. All patients received external pelvic radiotherapy, and 5 patients, received an additional intracavitary radiation therapy. The radiation dose from the external beam to the whole pelvis was 45 - 50 Gy. Vagina cuff irradiation was performed, after completion of the external beam irradiation, al a low-dose rate of CS-137, with the total dose of 4488-4932 chy (median: 4500 chy) at 5 mm depth from the vagina surface. The median follow-up period was 44 months (15-108 months), The 5-yr actuarial local control rate, distant free survival and disease-free survival rate were 98%, 95% and 94%, respectively. A univariate analysis of the clinical and pathological parameters revealed that the clinical stage (p=0.0145), status of vaginal resection margin (p=0.0002) and parametrial extension (p=0.0001) affected the disease-free survival. From a multivariate analysis, only a parametrial extension independently influenced the disease-free survival. Five patients (9%) experienced Grade 2 late treatment-related complications, such as radiation proctitis (1 patient), cystitis (3 patients) and lymphedema of the leg (1 patient). No patient had grade 3 or 4 complications. Our results indicate that postoperative radiation therapy can achieve good local control and survival rates for patients with stages IB-IIB cervical cancer, treated with a simple hysterectomy, as well as for those treated with a radical hysterectomy, and with unfavorable pathological findings. The prognostic factor for disease-free survival was invasion of the parametrium. The prognostic factor identified in this study for treatment failure can be used as a selection criterion for the combined treatment of radiation and chemotherapy

  5. Adjuvant postoperative radiation therapy for carcinoma of the uterine cervix

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Ja; Moon, Hye Seong; Kim, Seung Cheol; Kim, Chong Il; Ahn, Jung Ja [College of Medicine, Ewha Womans Univ., Seoul (Korea, Republic of)

    2003-09-01

    This study was undertaken to evaluate the efficacy of postoperative radiotherapy, and to investigate the prognostic factors for FIGO stages IB-IIB cervical cancer patients who were treated with simple hysterectomy, or who had high-risk factors following radical hysterectomy and pelvic lymph node dissection. Between March 1986 and December 1998, 58 patients, with FIGO stages IB-IIB cervical cancer were included in this study, The indications for postoperative radiation therapy were based on the pathological findings, including lymph node metastasis, positive surgical margin, parametrial extension, Iymphovascular invasion, invasion of more than half the cervical stroma, uterine extension and the incidental finding of cervix cancer following simple hysterectomy. All patients received external pelvic radiotherapy, and 5 patients, received an additional intracavitary radiation therapy. The radiation dose from the external beam to the whole pelvis was 45 - 50 Gy. Vagina cuff irradiation was performed, after completion of the external beam irradiation, al a low-dose rate of CS-137, with the total dose of 4488-4932 chy (median: 4500 chy) at 5 mm depth from the vagina surface. The median follow-up period was 44 months (15-108 months), The 5-yr actuarial local control rate, distant free survival and disease-free survival rate were 98%, 95% and 94%, respectively. A univariate analysis of the clinical and pathological parameters revealed that the clinical stage (p=0.0145), status of vaginal resection margin (p=0.0002) and parametrial extension (p=0.0001) affected the disease-free survival. From a multivariate analysis, only a parametrial extension independently influenced the disease-free survival. Five patients (9%) experienced Grade 2 late treatment-related complications, such as radiation proctitis (1 patient), cystitis (3 patients) and lymphedema of the leg (1 patient). No patient had grade 3 or 4 complications. Our results indicate that postoperative radiation therapy can achieve good local control and survival rates for patients with stages IB-IIB cervical cancer, treated with a simple hysterectomy, as well as for those treated with a radical hysterectomy, and with unfavorable pathological findings. The prognostic factor for disease-free survival was invasion of the parametrium. The prognostic factor identified in this study for treatment failure can be used as a selection criterion for the combined treatment of radiation and chemotherapy.

  6. Treatment of uterine leiomyoma with magnetic resonance-guided focused ultrasound surgery (MRgFUS)

    International Nuclear Information System (INIS)

    Uterine leiomyoma is the most common pelvic tumor in women. Although hysterectomy has long been the standard treatment for uterine myoma, some uterus-preserving alternatives are available today. Among these, magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a minimally-invasive procedure that uses high intensity ultrasound waves to ablate tissue. The present study investigates the efficacy of MRgFUS in the treatment of uterine myoma and the histopathological features on extirpated myoma tissue, when alternative surgical treatment is requisite. The Ethics Committee of Shinsuma Hospital approved the treatment of uterine myoma by MRgFUS, and written informed consent was obtained from all of the patients in compliance with the principles of good clinical practice. Between June 2004 and March 2007, 81 premenopausal patients with 125 myomas confirmed by T2-weighted MRI were treated by MRgFUS. The myomas were classified into 3 types based on signal intensity of T2-weighted images type I, low intensity; type II, intermediate intensity and type III, high intensity. The ablation (the non-perfused ratio of gadolinium injection) was about 55% in type I and type II, and 38% in type III. There was no correlation between the ablation ratio and the location or the size of the myoma. The uterine muscle was spared ablation when 2 combined myomas were treated as one tumor, suggesting that the vascularity was richer in the uterine muscle layer than in the myoma Sufficient ablation of the myoma near the Os sacrum is not able to attain immediately after the treatment; however, in several cases a complete non-perfusion margin was observed 3 or 6 months after the treatment. These cases yield very satisfactory results and it is meaningful to search for the reason why such good results were induced. Alternative treatment such as hysterectomy, myomectomy, trans cervical resection (TCR) or uterine artery embolization (UAE) was indicated for 13.6% of the patients. Here, we demonstrate a case of leiomyosarcoma disclosed after MRgFUS and display T2-weighted schemas of myoma and leiomyosarcoma before and 6 months after treatment, attesting to the essentiality of follow-up after the procedure. MRgFUS was of little effect in cases of cellular leiomyoma in which regrowth of leiomyoma cells was observed at the periphery of the myoma. Necl-2 and COX-2 were positive in cellular leiomyoma tissue, as are myogenic stem cells in skeletal muscle. Moreover, numerous mast cells and abundant vascularity was found in cellular leiomyomas. These results suggest that cellular leiomyoma and myoma with hypervascularity or degenerative changes are resistant to MRgFUS treatment. (author)

  7. Enzymes of the AKR1B and AKR1C subfamilies and uterine diseases

    Directory of Open Access Journals (Sweden)

    TeaLanisnik Rizner

    2012-03-01

    Full Text Available Endometrial and cervical cancers, uterine myoma, and endometriosis are very common uterine diseases. Worldwide, more than 800,000 women are affected annually by gynecological cancers, as a result of which, more than 360,000 die. During their reproductive age, about 70% of women develop uterine myomas, 10% to 15% suffer from endometriosis, and 35% to 50% from infertility associated with endometriosis. Uterine diseases are associated with aberrant inflammatory responses and concomitant increased production of prostaglandins (PG. They are also related to decreased differentiation, due to low levels of protective progesterone and retinoic acid, and to enhanced proliferation, due to high local concentrations of estrogens. The pathogenesis of these diseases can thus be attributed to disturbed PG, estrogen and retinoid metabolism and actions. Five human members of the aldo-keto reductase 1B (AKR1B and 1C (AKR1C superfamilies, i.e., AKR1B1, AKR1B10, AKR1C1, AKR1C2 and AKR1C3, have roles in these processes and can thus be implicated in uterine diseases. AKR1B1 and AKR1C3 catalyze the formation of PGF2alpha which stimulates cell proliferation. AKR1C3 converts PGD2 to 9alpha,11beta-PGF2, and thus counteracts the formation of 15deoxy-PGJ2, which can activate pro-apoptotic peroxisome-proliferator-activated receptor beta. AKR1B10 catalyzes the reduction of retinal to retinol, and in thus lessens the formation of retinoic acid, with potential pro-differentiating actions. The AKR1C1-AKR1C3 enzymes also act as 17-keto- and 20-ketosteroid reductases to varying extents, and are implicated in increased estradiol and decreased progesterone levels. This review comprises a short introduction to uterine diseases, followed by an overview of the current literature on the AKR1B and AKR1C expression in the uterus and in uterine diseases. The potential implications of the AKR1B and AKR1C enzymes and their pathophysiologies are then discussed, followed by conclusions and future perspectives.

  8. Coexistence of early microinvasive endometrioid adenocarcinoma and CIN3 in the uterine cervix in a 32-year-old Japanese woman

    Directory of Open Access Journals (Sweden)

    Terada Tadashi

    2011-06-01

    Full Text Available Abstract Simultaneous occurrence of early microinvasive endometrioid adenocarcinoma (EMEA and CIN 3 in the uterine cervix is very rare in Japan. A 32-year-old Japanese woman was pointed out to have atypical cells in the cervical cytology. Colposcopic examination revealed irregular lesions in the cervix, and a biopsy showed simultaneous EMEA and CIN3. The EMEA was grade I and CIN3 corresponded to severe dysplasia/carcinoma in situ. Hysterectomy and lymph nodes dissection were performed. Grossly, mucosal irregularity and erosion were seen in the cervix. No tumor formation was recognized. The cervix was examined by serial sections. Microscopically, there were a tiny adenocarcinoma (0.5 cm in diameter and 0.3 cm in depth and broad areas of CIN3. The adenocarcinoma was EMEA without mucins. The EMEA was FIGO stage 1A1. Immunohistochemically, the EMEA was positive for pancytokeratins (AE1/2 +++, CAM5.2 ++, cytokeratin (CK 34?E12 +, CK5/6 +, CK7 +, CK18 +++, CK19 ++, CA19-9 +, CA125 +++, p53 +, ER +++, PgR +++, while it was negative for CK8, CK14, CK20, EMA, vimentin, CEA, desmin, smooth muscle actin, p63, chromogranin, synaptophysin, CD56, CD68, HER2/neu, MUC1, MUC2, MUC5AC, and MUC6. The CIN 3 was positive for pancytokeratins (AE1/2 +++, CAM5.2 +, cytokeratin (CK 34?E12 +++, CK5/6 +++, CK7 +, EMA, CA19-9 +, CA125 +, p53 +, p63 +++, ER +++, and MUC1 +, while it was negative for CK8, CK14, CK18, CK19, CK20, vimentin, CEA, desmin, smooth muscle actin, chromogranin, synaptophysin, CD56, CD68, PgR, HER2/neu, MUC2, MUC5AC and MUC6. The lymph nodes showed no metastatic lesions (0/34. In conclusion, the author reported a rare case of simultaneous EMEA and CIN 3 with extensive immunohistochemical findings.

  9. Rectal sonography before and after radiation treatment in inoperable cervical cancer

    International Nuclear Information System (INIS)

    Transrectal sonography is helpful in the classification of parametrial infiltration prior to treatment as well as in the follow-up. In this study, we performed rectal sonography in cases of inoperable cervical cancer to objectify the reduction of the infiltration of the uterine cervix and of the parametrium. Rectosonography was performed in 10 patients with histologically confirmed cancer of the uterine cervix before and after radiation treatment. The patients were treated with brachytherapy and teletherapy with an average radiation dose of 7680 rad. The whole therapy was finished after 6 to 9 weeks. Rectosonography enabled us to objectify the effect of radiation therapy. The length and width of parametrial infiltration could be measured in relation to the pelvis wall. Furthermore, the configuration of the parametrium could be imaged. Therefore, in cervical cancer, rectosonography is a valuable method to check and the documentate the effect of treatment and to diagnose recurrency. (orig.)

  10. Chromosomal imbalances in four new uterine cervix carcinoma derived cell lines

    International Nuclear Information System (INIS)

    Uterine cervix carcinoma is the second most common female malignancy worldwide and a major health problem in Mexico, representing the primary cause of death among the Mexican female population. High risk human papillomavirus (HPV) infection is considered to be the most important risk factor for the development of this tumor and cervical carcinoma derived cell lines are very useful models for the study of viral carcinogenesis. Comparative Genomic Hybridization (CGH) experiments have detected a specific pattern of chromosomal imbalances during cervical cancer progression, indicating chromosomal regions that might contain genes that are important for cervical transformation. We performed HPV detection and CGH analysis in order to initiate the genomic characterization of four recently established cervical carcinoma derived cell lines from Mexican patients. All the cell lines were HPV18 positive. The most prevalent imbalances in the cell lines were gains in chromosomes 1q23-q32, 3q11.2-q13.1, 3q22-q26.1, 5p15.1-p11.2, this alteration present as a high copy number amplification in three of the cell lines, 7p15-p13, 7q21, 7q31, 11q21, and 12q12, and losses in 2q35-qter, 4p16, 6q26-qter, 9q34 and 19q13.2-qter. Analysis of our present findings and previously reported data suggest that gains at 1q31-q32 and 7p13-p14, as well as losses at 6q26-q27 are alterations that might be unique for HPV18 positive cases. These chromosomal regions, as well as regions with high copy number amplifications, coincide with known fragile sites and known HPV integration sites. The general pattern of chromosomal imbalances detected in the cells resembled that found in invasive cervical tumors, suggesting that the cells represent good models for the study of cervical carcinoma

  11. Concentrated leak erosion

    OpenAIRE

    Bonelli, S.; N. BENAHMED; Fell, R.

    2012-01-01

    Chapter 5, written by Nadia Benahmed, Christophe Chevalier and Stéphane Bonelli, is concerned with flow erosion as it takes place in a pipe. In fact, this chapter thoroughly analyses the “Hole Erosion Test”, which was carried out for hydraulic structures in the United States and Australia, and recently in France. Several laboratory tests show the influence on erosion parameters of the clay nature, of the soil water content and of its density. Finally, this chapter emphasizes the i...

  12. Modeling of Polymer Erosion

    OpenAIRE

    Göpferich, Achim; Langer, Robert S.

    1993-01-01

    The erosion of bioerodible polymers depends on many factors including the polymer chain length, bond cleavage velocity, swellability, crystallinity, and water diffusivity in the polymer matrix. This multitude of parameters makes modeling of erosion difficult. Only a few models exist that describe morphological changes of polymers during erosion qualitatively. In the present approach the polymer matrix was represented as the sum of small individual polymer matrix parts. The factors that determ...

  13. Saliva and dental erosion

    OpenAIRE

    Marília Afonso Rabelo Buzalaf; Angélicas Reis Hannas; Melissa Thiemi Kato

    2012-01-01

    Dental erosion is a multifactorial condition. The consideration of chemical, biological and behavioral factors is fundamental for its prevention and therapy. Among the biological factors, saliva is one of the most important parameters in the protection against erosive wear. Objective: This review discusses the role of salivary factors on the development of dental erosion. Material and Methods: A search was undertaken on MeDLINe website for papers from 1969 to 2010. The keywords used in the re...

  14. Erosion-corrosion; Erosionkorrosion

    Energy Technology Data Exchange (ETDEWEB)

    Aghili, B

    1999-05-01

    A literature study on erosion-corrosion of pipings in the nuclear industry was performed. Occurred incidents are reviewed, and the mechanism driving the erosion-corrosion is described. Factors that influence the effect in negative or positive direction are treated, as well as programs for control and inspection. Finally, examples of failures from databases on erosion-corrosion are given in an attachment 32 refs, 16 figs, tabs

  15. Fluoride in dental erosion

    OpenAIRE

    A. C. Magalhães; Wiegand, A.; D. Rios; Buzalaf, M A R; Lussi, A.

    2011-01-01

    Dental erosion develops through chronic exposure to extrinsic/intrinsic acids with a low pH. Enamel erosion is characterized by a centripetal dissolution leaving a small demineralized zone behind. In contrast, erosive demineralization in dentin is more complex as the acid-induced mineral dissolution leads to the exposure of collagenous organic matrix, which hampers ion diffusion and, thus, reduces further progression of the lesion. Topical fluoridation inducing the formation of a protective l...

  16. Impacts of soil erosion

    OpenAIRE

    Dorren, Luuk; De la Rosa, Diego; Theocharopoulos, Sid. P.

    2004-01-01

    3.1 Definition of soil functions, soil quality and quality targets The identification of soil functions, properties and processes which are affected by soil erosion is needed to evaluate the impacts of erosion on the soil system. Definition of soil loss tolerance according to soil types and environmental characteristics. 3.2 Development of criteria and indicators to assess soil sustainable use and soil protection measures What are the impacts of soil erosion on soil...

  17. Abnormal uterine bleeding: a clinicohistopathological analysis

    OpenAIRE

    Anupamasuresh Y; Suresh YV; Prachi Jain

    2014-01-01

    Background: Abnormal uterine bleeding (AUB) is one of the most common problem for the patients and the gynecologists. It adversely effects on the quality of life and psychology of women. It is of special concern in developing country as it adds to the causes of anemia. Management of Abnormal Uterine Bleeding (AUB) is not complete without tissue diagnosis especially in perimenopausal and post-menopausal women. Histological characteristics of endometrial biopsy material as assessed by light mic...

  18. Progressive genetic aberrations detected by comparative genomic hybridization in squamous cell cervical cancer

    OpenAIRE

    Allen, D.G.; White, D. J.; Hutchins, A-M; Scurry, J P; Tabrizi, S. N.; Garland, S. M.; Armes, J E

    2000-01-01

    Genetic changes orchestrated by human papillomaviruses are the most important known factors in carcinogenesis of the uterine cervix. However, it is clear that additional genetic events are necessary for tumour progression. We have used comparative genomic hybridization to document non-random chromosomal gains and losses within a subset of 37 cervical carcinomas matched for clinical stage Ib, but with different lymph node status. There were significantly more chromosomal changes in the primary...

  19. How valid are current diagnostic criteria for dental erosion?

    OpenAIRE

    Ganss, Carolina

    2008-01-01

    In principle, there is agreement about the clinical diagnostic criteria for dental erosion, basically defined as cupping and grooving of the occlusal/incisal surfaces, shallow defects on smooth surfaces located coronal from the enamel–cementum junction with an intact cervical enamel rim and restorations rising above the adjacent tooth surface. This lesion characteristic was established from clinical experience and from observations in a small group of subjects with known exposure to acids rat...

  20. Intra-arterial infusion chemoradiotherapy for advanced carcinoma of the uterine cervix

    International Nuclear Information System (INIS)

    Prognosis for patients with advanced uterine cervical cancer is still poor. In order to improve the prognosis for such patients, further effort is required. Intra-arterial infusion chemotherapy (IAIC) is considered to be useful for improvement of local control and survival. Many investigations have shown encouraging results for local control, but many reports have shown no definite effect on survival time. We analyzed 29 cases of Stage III squamous cell carcinoma of the uterine cervix treated with radiotherapy and IAIC of cisplatin (CDDP) from 1991 to 2006. Five-year overall survival (OAS) rate for Stage III patients was 62%, cause specific survival (CSS) rate was 70% and local relapse-free survival rate was 89%. Severe late complication rates (Grade 3?) of the bladder, rectum and intestine were 3%, 3% and 10%, respectively. Our study showed good local control, although numerous extra-pelvic distant metastases, especially para-aortic node (PAN) metastases were noted. Therefore, in order to decrease distant metastases, it is thought that some whole body chemotherapies are necessary. We should evaluate the position of the catheter and the drug distribution from the effectiveness and safety points of view. We confirmed excellent drug distribution directly by using angio-CT. To improve the survival rate for advanced cervical cancer, it is advocated that to improve local control IAIC be considered, and to reduce potential systemic disease, systemic chemotherapy be considered. In order to improve the prognosis of these patients, we should furthermore consider a combination of IAIC and systemic chemotherapy. (author)

  1. Definition of Compartment Based Radical Surgery in Uterine Cancer—Part I: Therapeutic Pelvic and Periaortic Lymphadenectomy by Michael Höckel Translated to Robotic Surgery

    Science.gov (United States)

    Kimmig, Rainer; Iannaccone, Antonella; Buderath, Paul; Aktas, Bahriye; Wimberger, Pauline; Heubner, Martin

    2013-01-01

    Objective. To define compartment based therapeutic pelvic and periaortic lymphadenectomy in cervical and endometrial cancer. Compartment based oncologic surgery appears to be favorable for patients in terms of radicality as well as complication rates, and the same appears to be true for robotic surgery. We describe a method of robotically assisted compartment based lymphadenectomy step by step in uterine cancer and demonstrate feasibility data from 35 patients. Methods. Patients with the diagnosis of endometrial (n = 16) or cervical (n = 19) cancer were included. Patients were treated by rTMMR (robotic total mesometrial resection) or rPMMR (robotic peritoneal mesometrial resection) and pelvic or pelvic/periaortic rtLNE (robotic therapeutic lymphadenectomy) with cervical cancer FIGO IB-IIA or endometrial cancer FIGO I-III. Results. No transition to open surgery was necessary. Complication rates were 13% for endometrial cancer and 21% for cervical cancer. Within follow-up time median (22/20) month we noted 1 recurrence of cervical cancer and 2 endometrial cancer recurrences. Conclusions. We conclude that compartment based rtLNE is a feasible and safe technique for the treatment of uterine cancers and is favorable in aspects of radicality and complication rates. It should be analyzed in multicenter studies with extended followup on the basis of the described technique. PMID:23589777

  2. Definition of compartment based radical surgery in uterine cancer-part I: therapeutic pelvic and periaortic lymphadenectomy by Michael höckel translated to robotic surgery.

    Science.gov (United States)

    Kimmig, Rainer; Iannaccone, Antonella; Buderath, Paul; Aktas, Bahriye; Wimberger, Pauline; Heubner, Martin

    2013-01-01

    Objective. To define compartment based therapeutic pelvic and periaortic lymphadenectomy in cervical and endometrial cancer. Compartment based oncologic surgery appears to be favorable for patients in terms of radicality as well as complication rates, and the same appears to be true for robotic surgery. We describe a method of robotically assisted compartment based lymphadenectomy step by step in uterine cancer and demonstrate feasibility data from 35 patients. Methods. Patients with the diagnosis of endometrial (n = 16) or cervical (n = 19) cancer were included. Patients were treated by rTMMR (robotic total mesometrial resection) or rPMMR (robotic peritoneal mesometrial resection) and pelvic or pelvic/periaortic rtLNE (robotic therapeutic lymphadenectomy) with cervical cancer FIGO IB-IIA or endometrial cancer FIGO I-III. Results. No transition to open surgery was necessary. Complication rates were 13% for endometrial cancer and 21% for cervical cancer. Within follow-up time median (22/20) month we noted 1 recurrence of cervical cancer and 2 endometrial cancer recurrences. Conclusions. We conclude that compartment based rtLNE is a feasible and safe technique for the treatment of uterine cancers and is favorable in aspects of radicality and complication rates. It should be analyzed in multicenter studies with extended followup on the basis of the described technique. PMID:23589777

  3. Zearalenone Effect on Uterine Weight of Rats

    Directory of Open Access Journals (Sweden)

    Sejad Mackic

    2012-10-01

    Full Text Available Mycotoxins are today considered one of the main contaminants of food and feed. Widespread zearalenone and its metabolites have potent estrogenic and anabolic activity, proven in numerous studies worldwide. The aim is to investigate influence of zearalenone on the uterine weight of rats depending on the applied dose and duration of the observation period. In a controlled experimental study, 63 adult female Wistar rats were divided into three groups, depending on the oral test dose of zearalenone applied: 0.1, 0.3 and 0.5 mg / kg of body weight. At the end of each of the four observation periods of seven days, animals were sacrificed under general anesthesia with ether, and after an autopsy the mass of the uterus was determined. Zearalenone in the dose of 0.1 mg / kg of body weight has caused a significant increase in uterine weight between the first and fourth observation interval. Doses of 0.3 and 0.5 mg zearalenone/ kg caused a decrease in uterine weight, which was at a dose of 0.5 mg / kg highly significant between all observational intervals. After 7 days of applying of the toxin, uterine weights did not differ significantly with respect to applied dose. After 14, 21 and 28 days, differences in uterine weight were highly significant, depending on the dose of zearalenone. The results show that prolonged application of large doses of zearalenone produced a significant decrease in uterine weights in experimental animals.

  4. The Differentially Expressed Genes by Radiotherapy in the Patients with Uterine Cervix Cancer

    International Nuclear Information System (INIS)

    Purpose : To detect differentially expressed genes in the patients with uterine cervical cancer during the radiation therapy. Materials and Methods : In patients with biopsy proven uterine cervical cancer, we took a tumor tissue just before radiation therapy and at 40 minutes after external irradiation of 1.8 Gy. Total RNAs isolated from non-irradiated and irradiated tumor tissue samples were analyzed using the differential-display reverse transcription-polymerase chain reaction (DDRT-PCR). Complementary DNA (cDNA) fragments corresponding to differentially expressed messenger RNAs(mRNAs) were eluted, and cloned. The differential expression of the corresponding mRNAs was confirmed by reverse northern blot. Differentially expressed cDNA bands were sequenced. Nucleotide sequence data were analyzed in the Gene Bank and EMBL databases via the BLAST network server to identify homologies to known genes or cDNA fragments. Expression pattern of down-regulated clone was examined using RT-PCR in 5 patients undergoing radiotherapy. Results : We identified 18 differentially expressed bands by DDRT-PCR, which were eluted and cloned. There were 10 up-regulated clones and 1 down-regulated clone in reverse northern blot. One cDNA fragment had homology to chemokine receptor CXCR4, four were identified as Human ESTs in the EMBL database in EST clones. Down-regulated CxCa-11 was also down regulated in all patients. Conclusion : Using the DDRT-PCR, we have identified 10 up-regulated and 1 down-regulated clone(s) in the patients with uterine cervix cancer during the radiation therapy. The clinical relevance and the functions of these genes will be further investigated

  5. The Differentially Expressed Genes by Radiotherapy in the Patients with Uterine Cervix Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Eun Young; Cho, Moon June; Lee, Jeung Hoon; Lee, Young Sook; Na, Myung Hoon; Lee, Woong Hee; Kim, Jun Sang; Kim, Jae Sung [Cancer Research Institute, Chungnam National University College of Medicine, Daejeon (Korea, Republic of)

    2001-12-15

    Purpose : To detect differentially expressed genes in the patients with uterine cervical cancer during the radiation therapy. Materials and Methods : In patients with biopsy proven uterine cervical cancer, we took a tumor tissue just before radiation therapy and at 40 minutes after external irradiation of 1.8 Gy. Total RNAs isolated from non-irradiated and irradiated tumor tissue samples were analyzed using the differential-display reverse transcription-polymerase chain reaction (DDRT-PCR). Complementary DNA (cDNA) fragments corresponding to differentially expressed messenger RNAs(mRNAs) were eluted, and cloned. The differential expression of the corresponding mRNAs was confirmed by reverse northern blot. Differentially expressed cDNA bands were sequenced. Nucleotide sequence data were analyzed in the Gene Bank and EMBL databases via the BLAST network server to identify homologies to known genes or cDNA fragments. Expression pattern of down-regulated clone was examined using RT-PCR in 5 patients undergoing radiotherapy. Results : We identified 18 differentially expressed bands by DDRT-PCR, which were eluted and cloned. There were 10 up-regulated clones and 1 down-regulated clone in reverse northern blot. One cDNA fragment had homology to chemokine receptor CXCR4, four were identified as Human ESTs in the EMBL database in EST clones. Down-regulated CxCa-11 was also down regulated in all patients. Conclusion : Using the DDRT-PCR, we have identified 10 up-regulated and 1 down-regulated clone(s) in the patients with uterine cervix cancer during the radiation therapy. The clinical relevance and the functions of these genes will be further investigated.

  6. Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study

    OpenAIRE

    Cooper, Natalie A.M.; Clark, T. Justin; Middleton, Lee; Diwakar, Lavanya; Smith, Paul; Denny, Elaine; Roberts, Tracy; Stobert, Lynda; Jowett, Susan; Daniels, Jane

    2015-01-01

    Objective To compare the effectiveness and acceptability of outpatient polypectomy with inpatient polypectomy. Design Pragmatic multicentre randomised controlled non-inferiority study. Setting Outpatient hysteroscopy clinics in 31 UK National Health Service hospitals. Participants 507 women who attended as outpatients for diagnostic hysteroscopy because of abnormal uterine bleeding and were found to have uterine polyps. Interventions Participants were randomly assigned to either outpatient ut...

  7. Saliva and dental erosion

    Directory of Open Access Journals (Sweden)

    Marília Afonso Rabelo Buzalaf

    2012-10-01

    Full Text Available Dental erosion is a multifactorial condition. The consideration of chemical, biological and behavioral factors is fundamental for its prevention and therapy. Among the biological factors, saliva is one of the most important parameters in the protection against erosive wear. Objective: This review discusses the role of salivary factors on the development of dental erosion. Material and Methods: A search was undertaken on MeDLINe website for papers from 1969 to 2010. The keywords used in the research were "saliva", "acquired pellicle", "salivary flow", "salivary buffering capacity" and "dental erosion". Inclusion of studies, data extraction and quality assessment were undertaken independently and in duplicate by two members of the review team. Disagreements were solved by discussion and consensus or by a third party. Results: Several characteristics and properties of saliva play an important role in dental erosion. Salivary clearance gradually eliminates the acids through swallowing and saliva presents buffering capacity causing neutralization and buffering of dietary acids. Salivary flow allows dilution of the acids. In addition, saliva is supersaturated with respect to tooth mineral, providing calcium, phosphate and fluoride necessary for remineralization after an erosive challenge. Furthermore, many proteins present in saliva and acquired pellicle play an important role in dental erosion. Conclusions: Saliva is the most important biological factor affecting the progression of dental erosion. Knowledge of its components and properties involved in this protective role can drive the development of preventive measures targeting to enhance its known beneficial effects.

  8. Saliva and dental erosion

    Scientific Electronic Library Online (English)

    Marília Afonso Rabelo, Buzalaf; Angélicas Reis, Hannas; Melissa Thiemi, Kato.

    2012-10-01

    Full Text Available Dental erosion is a multifactorial condition. The consideration of chemical, biological and behavioral factors is fundamental for its prevention and therapy. Among the biological factors, saliva is one of the most important parameters in the protection against erosive wear. Objective: This review di [...] scusses the role of salivary factors on the development of dental erosion. Material and Methods: A search was undertaken on MeDLINe website for papers from 1969 to 2010. The keywords used in the research were "saliva", "acquired pellicle", "salivary flow", "salivary buffering capacity" and "dental erosion". Inclusion of studies, data extraction and quality assessment were undertaken independently and in duplicate by two members of the review team. Disagreements were solved by discussion and consensus or by a third party. Results: Several characteristics and properties of saliva play an important role in dental erosion. Salivary clearance gradually eliminates the acids through swallowing and saliva presents buffering capacity causing neutralization and buffering of dietary acids. Salivary flow allows dilution of the acids. In addition, saliva is supersaturated with respect to tooth mineral, providing calcium, phosphate and fluoride necessary for remineralization after an erosive challenge. Furthermore, many proteins present in saliva and acquired pellicle play an important role in dental erosion. Conclusions: Saliva is the most important biological factor affecting the progression of dental erosion. Knowledge of its components and properties involved in this protective role can drive the development of preventive measures targeting to enhance its known beneficial effects.

  9. CURATIVE CONDUCT IN UTERIN CERVIX LESIONS

    OpenAIRE

    Eduard Crauciuc; Dorina Neacsu; Ovidiu Toma; Dragos Crauciuc

    2012-01-01

    When talking about the feminine population, for which cervical cancer is an important problem of publichealth, it is very important to have an activity of detecting and treating preinvasive cervical lesions in the family planningoffices, in collaboration with specialized doctors from specialized services. The study intends to find out the possibilitiesand limitations in diagnosing and treating preinvasive cervical lesions. The study was made on a heterogenic lot ofpatients (n=16732), of which...

  10. Operable stages IB and 2 cervical carcinomas: a retrospective study comparing between preoperative utero vaginal brachytherapy and postoperative radiation therapy; Cancer du col uterin stades IB et 2 operable: comparaison retrospective entre curietherapie uterovaginale preoperatoire et chirurgie premiere suivies d'une radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Atlan, D.; Touboul, E.; Deniaud-Alexandre, E.; Ganansia, V.; Bernard, A. [Hopital Tenon, Oncologie-Radiotherapie, 75 - Paris (France); Lefranc, J.P.; Blondon, J. [Groupe Hospitalier la Pitie-Salpetriere, Chirurgie Gynecologique, 75 - Paris (France); Antoine, J.M.; Uzan, S. [Hopital Tenon, Gyneco-Obstetrique, 75 - Paris (France); Jannet, D.; Milliez, J. [Hopital Saint Antoine, Gyneco-Obstetrique, 75 - Paris (France); Lhuillier, P.E. [Hopital de Fontainebleau, Gyneco-Obstetrique, 77 - Fontainebleau (France); Uzan, M. [Hopital Jean-Verdier, Gyneco-Obstetrique, 93 - Bondy (France); Genestie, C. [Groupe Hospitalier la Pitie-Salpetriere, Anatamo-Pathologie, 75 - Paris (France); Antoine, M. [Hopital Tenon, Anatomopathologie, 75 - Paris (France); Jamali, M. [Hopital Saint-Antoine, Anatomopathologie, 75 - Paris (France)

    2002-06-01

    Purpose. -To identify prognostic factors and treatment toxicity in a series of operable stages IB and II cervical carcinomas. Patients and methods. - Between May 1972 and January 1994, 414 patients (pts) with cervical carcinoma staged according to the 1995 FIGO staging system underwent radical hysterectomy with (n=380) or without (n=34) bilateral pelvic lymph node dissection. Lateral ovarian transposition to preserve ovarian function was performed on 12 pts. The methods of radiation therapy (RT) were not randomized and depended on the usual practices of the surgical teams. Group I:168 pts received postoperative RT (64 pts received vaginal brachytherapy alone (mean total dose (MD): 50 Gy], 93 pts had external beam pelvis RT (EBPRT) [MD: 45 Gy over 5 weeks] followed by vaginal brachytherapy [MD: 20 Gy], and 11 pts had EBPRT alone [MD: 50 Gy over 6 weeks]. Group II: 246 pts received preoperative utero-vaginal brachytherapy [MD: 65 Gy], and 32 of theses 246 pts also received postoperative EBPRT [MD: 45 Gy over 5 weeks] delivered to the parametric and the pelvic lymph nodes with a midline pelvic shield. The mean follow-up was 106 months. Results. - The 10-year disease-free survival (DFS) rate was 80%. From 75 recurrences, 35 were isolated locoregional. Multivariate analysis showed that independent factors decreasing the probability of DFS were: both exo and endo-cervical tumour site (p=0.047), lymph-vascular space invasion (p=0.041), age {<=} 51 yr (p=0.013), 1995 FIGO staging system (stage IB1 vs stage IIA, p=0.004, stage IB1 vs stage IB2, p=0.0009, and stage IB1 vs stage IIB with 1/3 proximal parametrical infiltration, p=0.00002), and histological pelvic involved lymph nodes (p=0.00009). Methods of adjuvant RT did not influence the probability of DFS (group I vs group II, p=0.10). The postoperative complication rate was 10.2% in group I and 8.9% in group II (p=0.7) but the postoperative urethral complication rate necessitating surgical intervention with re-implantation was lower in group I than in group II (0.6% vs 2.3%, respectively, p=0.03). The 10-year rate for grade 3 and 4 late radiation complications according to the LENT-SOMA scoring system was 10.4%. EPRT significantly increased the 10-year rate for grade 3 and 4 late radiation complications (yes vs no: 22% vs 7%, respectively, p=0.0002). Conclusion. - In our series, the methods of adjuvant RT (primary surgery vs preoperative utero-vaginal brachytherapy) do not seem to influence the prognosis of the stage IB, IIA, and IIB - (with 1/3 proximal parametrical involvement only) cervical carcinomas. The postoperative EPRT applied according to histopathological risk factors after surgical treatment increases the risk of late radiation complications. (author)

  11. Definition of Compartment Based Radical Surgery in Uterine Cancer—Part I: Therapeutic Pelvic and Periaortic Lymphadenectomy by Michael Höckel Translated to Robotic Surgery

    OpenAIRE

    Rainer Kimmig; Antonella Iannaccone; Paul Buderath; Bahriye Aktas; Pauline Wimberger; Martin Heubner

    2013-01-01

    Objective. To define compartment based therapeutic pelvic and periaortic lymphadenectomy in cervical and endometrial cancer. Compartment based oncologic surgery appears to be favorable for patients in terms of radicality as well as complication rates, and the same appears to be true for robotic surgery. We describe a method of robotically assisted compartment based lymphadenectomy step by step in uterine cancer and demonstrate feasibility data from 35 patients. Methods. Patients with the diag...

  12. Erosion of a geopolymer.

    Energy Technology Data Exchange (ETDEWEB)

    Goretta, K. C.; Chen, N.; Routbort, J. L.; Lukey, G. C.; van Deventer, J. S. J.

    2002-07-02

    Solid-particle erosion studies were conducted on a representative geopolymer. The test conditions were normal impact of 390-{micro}m angular Al{sub 2}O{sub 3} erodent particles moving at 50, 70, or 100 m/s. Steady-state erosion rates were obtained and the material-loss mechanism was studied by scanning electron microscopy. The geopolymer responded as a classic brittle material. Elastic-plastic indentation events led to formation of brittle cleavage cracks that resulted in spallation of material. The erosion rate was proportional to erodent velocity to the 2.3 power. The erosion rate and mechanism for the geopolymer were nearly identical to what has been observed for erosion of Si single crystals.

  13. Uterine Artery Embolization to Treat Uterine Adenomyosis with or without Uterine Leiomyomata: Results of Symptom Control and Health-Related Quality of Life 40 Months after Treatment

    International Nuclear Information System (INIS)

    Purpose: To evaluate the clinical outcome for uterine adenomyosis with or without uterine leiomyomata 40 months after uterine artery embolization (UAE). Methods: Forty women aged 39–56 years (median 46 years) with symptomatic uterine adenomyosis and magnetic resonance imaging findings of uterine adenomyosis with or without combined uterine leiomyomata underwent UAE. Self-perceived changes in clinical symptoms were assessed, and residual symptom severity and health-related quality of life (HRQOL) after UAE were evaluated. Clinical failure was defined as no symptomatic improvement or second invasive therapy after UAE. Results were stratified by the extent of uterine adenomyosis at baseline magnetic resonance imaging. Results: Patients were followed for a median of 40 months (range 5–102 months). UAE led to symptomatic control after UAE in 29 (72.5%) of 40 patients while 11 women underwent hysterectomy (n = 10) or dilatation and curettage (n = 1) for therapy failure. No significant difference between women with pure uterine adenoymosis and women with uterine adenomyosis combined with uterine leiomyomata was observed. Best results were shown for UAE in uterine adenomyosis with uterine leiomyomata predominance as opposed to predominant uterine adenomyosis with minor fibroid disease (clinical failure 0% vs. 31.5%, P = 0.058). Throughout the study group, HRQOL score values increased and symptom severity scores decreased after UAE. Least improvement was noted for women with pure adenomyosis. Conclusions: UAE is clinically effective in the long term in most women with uterine adenomyosis. Symptomatic control and HRQOL were highest in patients with combined disease of uterine adenomyosis but leiomyomata predominance.

  14. Rainfall erosivity in Europe.

    Science.gov (United States)

    Panagos, Panos; Ballabio, Cristiano; Borrelli, Pasquale; Meusburger, Katrin; Klik, Andreas; Rousseva, Svetla; Tadi?, Melita Per?ec; Michaelides, Silas; Hrabalíková, Michaela; Olsen, Preben; Aalto, Juha; Lakatos, Mónika; Rymszewicz, Anna; Dumitrescu, Alexandru; Beguería, Santiago; Alewell, Christine

    2015-04-01

    Rainfall is one the main drivers of soil erosion. The erosive force of rainfall is expressed as rainfall erosivity. Rainfall erosivity considers the rainfall amount and intensity, and is most commonly expressed as the R-factor in the USLE model and its revised version, RUSLE. At national and continental levels, the scarce availability of data obliges soil erosion modellers to estimate this factor based on rainfall data with only low temporal resolution (daily, monthly, annual averages). The purpose of this study is to assess rainfall erosivity in Europe in the form of the RUSLE R-factor, based on the best available datasets. Data have been collected from 1541 precipitation stations in all European Union (EU) Member States and Switzerland, with temporal resolutions of 5 to 60 min. The R-factor values calculated from precipitation data of different temporal resolutions were normalised to R-factor values with temporal resolutions of 30 min using linear regression functions. Precipitation time series ranged from a minimum of 5 years to a maximum of 40 years. The average time series per precipitation station is around 17.1 years, the most datasets including the first decade of the 21st century. Gaussian Process Regression (GPR) has been used to interpolate the R-factor station values to a European rainfall erosivity map at 1 km resolution. The covariates used for the R-factor interpolation were climatic data (total precipitation, seasonal precipitation, precipitation of driest/wettest months, average temperature), elevation and latitude/longitude. The mean R-factor for the EU plus Switzerland is 722 MJ mm ha(-1) h(-1) yr(-1), with the highest values (>1000 MJ mm ha(-1) h(-1) yr(-1)) in the Mediterranean and alpine regions and the lowest (erosivity density (erosivity normalised to annual precipitation amounts) was also the highest in Mediterranean regions which implies high risk for erosive events and floods. PMID:25622150

  15. Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma

    Directory of Open Access Journals (Sweden)

    Fukushima Masanori

    2009-02-01

    Full Text Available Abstract Background Lymph node dissection has proven prognostic benefits for patients with ovarian or uterine carcinoma; however, one of the complications associated with this procedure is lymphedema. We aimed to identify the factors that are associated with the occurrence of lymphedema after lymph node dissection for the treatment of ovarian or uterine carcinoma. Methods A total of 694 patients with histologically confirmed ovarian (135 patients or uterine cancer (258 with cervical cancer, 301 with endometrial cancer who underwent lymph node dissection were studied retrospectively. Logistic regression analyses were used to identify the risk factors associated with occurrence of lymphedema. Results Among ovarian and uterine cancer patients who underwent pelvic lymph node dissection, post-operative radiotherapy (odds ratio: 1.79; 95% confidence interval: 1.20–2.67; p = 0.006 was statistically significantly associated with occurrence of lymphedema. Conclusion There was no relationship between any surgical procedure and occurrence of lymphedema among patients undergoing pelvic lymphadenectomy. Our findings are supported by a sound biological rationale because they suggest that limb lymphedema is caused by pelvic lymph node dissection.

  16. Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma

    International Nuclear Information System (INIS)

    Lymph node dissection has proven prognostic benefits for patients with ovarian or uterine carcinoma; however, one of the complications associated with this procedure is lymphedema. We aimed to identify the factors that are associated with the occurrence of lymphedema after lymph node dissection for the treatment of ovarian or uterine carcinoma. A total of 694 patients with histologically confirmed ovarian (135 patients) or uterine cancer (258 with cervical cancer, 301 with endometrial cancer) who underwent lymph node dissection were studied retrospectively. Logistic regression analyses were used to identify the risk factors associated with occurrence of lymphedema. Among ovarian and uterine cancer patients who underwent pelvic lymph node dissection, post-operative radiotherapy (odds ratio: 1.79; 95% confidence interval: 1.20–2.67; p = 0.006) was statistically significantly associated with occurrence of lymphedema. There was no relationship between any surgical procedure and occurrence of lymphedema among patients undergoing pelvic lymphadenectomy. Our findings are supported by a sound biological rationale because they suggest that limb lymphedema is caused by pelvic lymph node dissection

  17. [Radiotelemetric studies on uterine motility in cows during the 3d period of labor and the early puerperal period].

    Science.gov (United States)

    Kostov, I; Bodurov, N

    1979-01-01

    The outside appearance of a one-channel radiotelemetric system is presented and a short description of supplementary devices for the study of uterine motility in cows is given. The radiotube consisting of an inductive converter and a two-transistor sound generator is described in short. The tube is placed directly in the uterine cavity through the cervical canal. The numerical values of contractile uterine activity in hours post delivery up to the 120 hour are presented in one table and a graph. Original registering of normal uterine activity and of reflectory inhibition of the same are shown as well as registerings of other functions of the organism through the uterus such as urination, defecation, lowing and belching. The contractile activity of the uterus during a normal course of the third stage of labour and the early puerperium is most strongly expressed during the first day post calving. The duration of this activity in the following days is directly dependent on the individual characteristics of the organism. PMID:545847

  18. Evaluation of cervical cancer detection with acoustic radiation force impulse ultrasound imaging

    Science.gov (United States)

    SU, YIJIN; DU, LIANFANG; WU, YING; ZHANG, JUAN; ZHANG, XUEMEI; JIA, XIAO; CAI, YINGYU; LI, YUNHUA; ZHAO, JING; LIU, QIAN

    2013-01-01

    The aim of this study was to evaluate the application of acoustic radiation force impulse (ARFI) ultrasound imaging and its potential value in the characterization of cervical cancer. ARFI ultrasound imaging of the uterine cervix was performed in 58 patients with cervical cancer prior to surgery. The diagnosis of cervical cancer was confirmed by pathological results in each case. eSie Touch elastography imaging (EI), Virtual Touch tissue imaging (VTI) and Virtual Touch tissue quantification (VTQ; Siemens Medical Solutions, Mountain View, CA, USA) were used to qualitatively and quantitatively analyze the elasticity and hardness of lesions. For statistical analysis, the non-parametric Mann-Whitney U test and the Student’s u test were used to compare the elastic parameters and the results. EI showed that, compared with the surrounding cervical tissue, 72.41% (42 of 58) of the malignant lesions showed 4th or 5th grade images and 27.59% (16 of 58) had 3rd grade images. The EI images showed a significant difference between the malignant lesions and the surrounding normal tissues (P<0.001). VTI showed that compared with the surrounding cervical tissue, 84.48% (49 of 58) of the malignant lesions were stiffer than the surrounding tissues and 15.52% (9 of 58) had black and white honeycomb-like images. The VTI images showed a significant difference between the malignant lesions and normal cervical tissues (P<0.001). The surrounding normal tissues had lower VTQ values, with a mean of 2.11±1.19 m/sec, while the VTQ values in malignant lesions were higher than the surrounding normal tissues (3.41±1.59 m/sec, P<0.001). ARFI ultrasound imaging of the uterine cervix may be an objective method for the assessment of soft tissues. It has high sensitivity and specificity in the evaluation of cervical cancer and therefore has good diagnostic value in clinical applications. PMID:23837060

  19. Clinical application of uterine artery embolization in treating uterine scar pregnancy

    International Nuclear Information System (INIS)

    Objective: To evaluate uterine artery embolization in treating uterine scar pregnancy. Methods: During the period from November 2007 to February 2010, 11 patients with uterine scar pregnancy were encountered in authors' hospital. All the patients had a history of lower uterine segment cesarean section. Four patients had to receive an emergency uterine artery embolization due to acute massive vaginal bleeding. The other 7 patients received intravenous chemotherapy with MTX (0.4 mg/kg/day, every 5 days as a treatment course). Emergency uterine artery embolization had to be carried out in three patients as they developed acute massive vaginal bleeding (blood loss ? 100 ml/hour) during the course of chemotherapy, while subsequent uterine artery embolization was performed in the remaining 4 patients after they had completed two courses of treatment when their blood HCG showed no significant decrease. The clinical results were analyzed. Results: Remarkable decrease in serum HCG was seen in all 11 patients after interventional management. The vaginal bleeding in 7 patients was significantly reduced within half an hour after uterine artery embolization. The uterus together with intact fertility was successfully preserved in all 11 patients. Conclusion: For the treatment of uterine scar pregnancy complicated by massive vaginal bleeding (blood loss ? 500 ml/24 h) and/or abnormal elevation of serum HCG (blood ?-HCG ? 20000 IU/L), ectopic pregnancy with the mass diameter ? 5 cm, uterine artery embolization treatment is very safe and effective. This technique can well preserve female patient's uterus and fertility ability. It is of value to employ this treatment in clinical practice. (authors)

  20. Effects of estradiol on uterine perfusion in anesthetized cyclic mares affected with uterine vascular elastosis.

    Science.gov (United States)

    Esteller-Vico, A; Liu, I K M; Vaughan, B; Steffey, E P; Brosnan, R J

    2016-01-01

    Uterine vascular elastosis in mares is characterized by degeneration of uterine vasculature through thickening of the elastin layers. Factors commonly associated with this degeneration include age, parity, and chronic uterine endometritis. Affected mares have also been shown to exhibit decreases in uterine blood flow and perfusion of the uterus. Due to the increased thickness of the elastin layers, we hypothesize that vasodilatation of the uterine vasculature is also impaired. To test the functionality of these vessels, we evaluated the vasodilatory effects of estradiol on the uterine vascular bed in mares with normal vasculature and mares with severe elastosis. Both groups were tested in estrus and diestrus. Fluorescent microspheres were used to determine basal blood perfusion, followed by the intravenous administration of 1.0?g/kg of 17?-estradiol. After 90min, perfusion was measured once again to determine the vascular response to estradiol. Control mares in estrus displayed a significant increase in total uterine blood flow after the administration of estradiol when compared to baseline levels. No other group had a significant increase in total blood flow and perfusion after estradiol administration. The administration of estradiol in control mares induced regional increases in perfusion in the uterine horns and uterine body during estrus and only in the uterine horns during diestrus. Mares affected by elastosis exhibited no regional differences in perfusion levels post-estradiol administration. The difference in the vasodilatory response induced by estradiol between reproductively healthy mares and mares affected with elastosis indicates that the functionality of the affected vessels is compromised. PMID:26642749

  1. The impact of Human papilloma virus (HPV infection on the development of cervical neoplasia

    Directory of Open Access Journals (Sweden)

    Vlad Gheorghita

    2008-08-01

    Full Text Available The genesis of uterine cervix carcinoma has as central etiology the active infection of human papilloma virus (HPV, especially high oncogenic risk subtypes. However, this is a necessary, but not sufficient cause of virtually all cases of cervical cancer worldwide. At present, the proportion of cervical carcinomas attributed to HPV infection is estimated at 99%. It is considered that the pathogenesis of cervical carcinoma is the result of the proliferation of one or, at most, a few HPV-infected cells. Invasive cervical cancer arises in cervical intraepithelial neoplasia, which in turn develops preferentially in squamous metaplasia of certain limited areas. These areas represent the most important morphologic characteristic in cervical intraepithelial neoplasia. It is still unknown the precise mechanism for the development of separate fields in HPV-related intraepithelial neoplasia and the variable susceptibility of reserve cells for different HPV genotypes. The goal of any cervical cancer screening test is to identify women who are at risk of cervical cancer development and to reassure others that do not belong to this category. Cervical cytology (Pap smears were the primary screening tests. More recently, carcinogenic HPV DNA testing has been included as adjunctive test or as a primary screening test based on the central role of carcinogenic HPV infection in the development of cervical cancer. New biomarkers, including those that measure the interaction of host and virus, are being considered either as stand-alone molecular assays or in conjunction with cytology or carcinogenic HPV DNA testing to improve its sensitivity or specificity, respectively. .Profilactic HPV vaccination of women who are sexually active may provide protection against HPV-16 or HPV-18 infection which may lead to cytological abnormalities, precancer or cancer.

  2. DNA of HPV and antibodies toward the protein E7 of HPV 16 as prediction factors in women with cervical cancer submitted to radiotherapy

    International Nuclear Information System (INIS)

    The effects of HPV infection on intrinsic tumor cell sensitivity to radiation therapy (RT) are not clear. Antibodies to HPV16-E7 protein are consistently detected in cervical cancer patients, the changes in the levels of these antibodies after RT thus may have prognostic implications. The aim of this study was to evaluate the antibodies to HPV16-E7 protein and the HPV status in cervical cancer patients before and after RT and to correlate these with clinic pathological parameters. Antibodies to peptide E7 and HPV DNA status before and after RT could have prognosis significance for patients with locally advanced uterine cervical carcinoma

  3. Abnormal Cervical Cancer Screening Test Results

    Science.gov (United States)

    ... FREQUENTLY ASKED QUESTIONS FAQ187 GYNECOLOGIC PROBLEMS Abnormal Cervical Cancer Screening Test Results • What is cervical cancer screening? • What causes abnormal cervical cancer screening test results? • ...

  4. Uterine adenosarcomas are mesenchymal neoplasms.

    Science.gov (United States)

    Piscuoglio, Salvatore; Burke, Kathleen A; Ng, Charlotte Ky; Papanastasiou, Anastasios D; Geyer, Felipe C; Macedo, Gabriel S; Martelotto, Luciano G; de Bruijn, Ino; De Filippo, Maria R; Schultheis, Anne M; Ioris, Rafael A; Levine, Douglas A; Soslow, Robert A; Rubin, Brian P; Reis-Filho, Jorge S; Weigelt, Britta

    2016-02-01

    Uterine adenosarcomas (UAs) are biphasic lesions composed of a malignant mesenchymal (ie stromal) component and an epithelial component. UAs are generally low-grade and have a favourable prognosis, but may display sarcomatous overgrowth (SO), which is associated with a worse outcome. We hypothesized that, akin to breast fibroepithelial lesions, UAs are mesenchymal neoplasms in which clonal somatic genetic alterations are restricted to the mesenchymal component. To characterize the somatic genetic alterations in UAs and to test this hypothesis, we subjected 20 UAs to a combination of whole-exome (n = 6), targeted capture (n = 13) massively parallel sequencing (MPS) and/or RNA sequencing (n = 6). Only three genes, FGFR2, KMT2C and DICER1, were recurrently mutated, all in 2/19 cases; however, 26% (5/19) and 21% (4/19) of UAs harboured MDM2/CDK4/HMGA2 and TERT gene amplification, respectively, and two cases harboured fusion genes involving NCOA family members. Using a combination of laser-capture microdissection and in situ techniques, we demonstrated that the somatic genetic alterations detected by MPS were restricted to the mesenchymal component. Furthermore, mitochondrial DNA sequencing of microdissected samples revealed that epithelial and mesenchymal components of UAs were clonally unrelated. In conclusion, here we provide evidence that UAs are genetically heterogeneous lesions and mesenchymal neoplasms. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. PMID:26592504

  5. Radical radiation therapy for adenocarcinoma of the uterine cervix

    Energy Technology Data Exchange (ETDEWEB)

    Toita, T. (Dept. of Radiology, Ryukyus Univ. School of Medicine, Okinawa (Japan)); Takizawa, Y. (Dept. of Radiology, Ryukyus Univ. School of Medicine, Okinawa (Japan)); Nakano, M. (Dept. of Radiology, Ryukyus Univ. School of Medicine, Okinawa (Japan)); Sueyama, H. (Dept. of Radiology, Ryukyus Univ. School of Medicine, Okinawa (Japan)); Kushi, A. (Dept. of Radiology, Ryukyus Univ. School of Medicine, Okinawa (Japan)); Kakihana, Y. (Dept. of Radiology, Ryukyus Univ. School of Medicine, Okinawa (Japan)); Ogawa, K. (Dept. of Radiology, Ryukyus Univ. School of Medicine, Okinawa (Japan)); Hara, R. (Dept. of Radiology, Ryukyus Univ. School of Medicine, Okinawa (Japan)); Higashi, M. (Dept. of Obstetrics and Gynecology, Ryukyus Unvi. School of Medicine, Okinawa (Japan)); Sakumoto, K. (Dept. of Obstetrics and Gynecology, Ryukyus Unvi. School of Medicine, Okinawa (Japan)); Moromizato, H. (Dept. of Obstetrics and Gynecology, Ryukyus Unvi. School of Medicine, Okinawa (Japan)); Kanazawa,

    1994-05-01

    20 patients with uterine cervical adenocarcinoma were treated with a combination of external beam and intracavitary irradiation (four patients stage IB, one stage IIA, three stage IIB and twelve patients stage IIIB). Seven patients were treated with high dose-rate (HDR) intracavitary irradiation, eleven with low dose-rate (LDR) intracavitary irradiation and two with HDR and LDR. Six out of the 20 patients experienced pelvic recurrence (all stage IIIB patients). Analysis of the relation between pelvic recurrence and dose rate of intracavitary irradiation revealed that LDR showed a higher pelvic disease control rate than HDR (6/7 vs. 0/4) in stage IIIB patients. Intracavitary irradiation doses of LDR were 1.2 to 1.5 times higher than those of HDR. Three out of the 20 patients developed rectal complication grade 2 (two patients treated with HDR, one with LDR). The five-year cumulative survival rate was 67.2% for all, 100% for stage I and II, and 43.3% for stage IIIB patients. (orig./MG)

  6. Radical radiation therapy for adenocarcinoma of the uterine cervix

    International Nuclear Information System (INIS)

    20 patients with uterine cervical adenocarcinoma were treated with a combination of external beam and intracavitary irradiation (four patients stage IB, one stage IIA, three stage IIB and twelve patients stage IIIB). Seven patients were treated with high dose-rate (HDR) intracavitary irradiation, eleven with low dose-rate (LDR) intracavitary irradiation and two with HDR and LDR. Six out of the 20 patients experienced pelvic recurrence (all stage IIIB patients). Analysis of the relation between pelvic recurrence and dose rate of intracavitary irradiation revealed that LDR showed a higher pelvic disease control rate than HDR (6/7 vs. 0/4) in stage IIIB patients. Intracavitary irradiation doses of LDR were 1.2 to 1.5 times higher than those of HDR. Three out of the 20 patients developed rectal complication grade 2 (two patients treated with HDR, one with LDR). The five-year cumulative survival rate was 67.2% for all, 100% for stage I and II, and 43.3% for stage IIIB patients. (orig./MG)

  7. Impact of MRI in the management and staging of cancer of the uterine cervix

    Energy Technology Data Exchange (ETDEWEB)

    Stenstedt, Kristina (Centre of Surgical Gastroenterology, Karolinska Univ. Hospital and Karolinska Inst., Stockholm (Sweden)); Hellstroem, Ann-Cathrin (Dept. of Gynecological Oncology, Radiumhemmet, Karolinska Univ. Hospital and Karolinska Inst., Stockholm (Sweden)); Fridsten, Susanne; Blomqvist, Lennart (Dept. of Diagnostic Radiology Karolinska Univ. Hospital and Karolinska Inst., Stockholm (Sweden))

    2011-04-15

    Background. Cervical carcinoma is the only gynecological tumor still being staged mainly by clinical examination and only a limited use of diagnostic radiology. Cross sectional imaging is increasingly used as an aid in the staging procedure. We wanted to assess the impact of magnetic resonance imaging (MRI) in addition to the clinical staging of patients with carcinoma of the uterine cervix. Material and methods. A retrospective single-centre analysis of 183 women referred to a tertiary referral centre for gynecological tumors (<= 65 years old) with cervical cancer diagnosed between January 1, 2003 and December 31, 2006 who have undergone an MRI investigation before start of treatment. Patient records were retrospectively reviewed and any change of the planned treatment after the MRI examination was noted. Results. In patients with cervical carcinoma FIGO stage Ia2-IIa treated surgically, the treatment plan was altered due to MRI results in 10/125 patients. In the smaller group of patients with clinically more advanced disease receiving radio-chemotherapy, the treatment plan was altered in 12/58 patients. Reasons for changing the treatment plan after MRI were findings indicating a higher (n = 8) or lower (n = 5) local tumor stage, findings of para aortic nodal disease (n = 4) or difficulty to clinically examine the patient due to obesity (n = 2). MRI was also an aid in deciding whether or not to offer fertility preserving treatment in three cases. Conclusion. The use of MRI affects treatment planning in patients with cancer of the uterine cervix. The impact is more obvious in more advanced stages of disease and in patients who are difficult to examine clinically due to, for example body constitution. The result of MRI is also an aid in deciding whether or not a fertility preserving operation is feasible

  8. Impact of MRI in the management and staging of cancer of the uterine cervix

    International Nuclear Information System (INIS)

    Background. Cervical carcinoma is the only gynecological tumor still being staged mainly by clinical examination and only a limited use of diagnostic radiology. Cross sectional imaging is increasingly used as an aid in the staging procedure. We wanted to assess the impact of magnetic resonance imaging (MRI) in addition to the clinical staging of patients with carcinoma of the uterine cervix. Material and methods. A retrospective single-centre analysis of 183 women referred to a tertiary referral centre for gynecological tumors (? 65 years old) with cervical cancer diagnosed between January 1, 2003 and December 31, 2006 who have undergone an MRI investigation before start of treatment. Patient records were retrospectively reviewed and any change of the planned treatment after the MRI examination was noted. Results. In patients with cervical carcinoma FIGO stage Ia2-IIa treated surgically, the treatment plan was altered due to MRI results in 10/125 patients. In the smaller group of patients with clinically more advanced disease receiving radio-chemotherapy, the treatment plan was altered in 12/58 patients. Reasons for changing the treatment plan after MRI were findings indicating a higher (n = 8) or lower (n = 5) local tumor stage, findings of para aortic nodal disease (n = 4) or difficulty to clinically examine the patient due to obesity (n = 2). MRI was also an aid in deciding whether or not to offer fertility preserving treatment in three cases. Conclusion. The use of MRI affects treatment planning in patients with cancer of the uterine cervix. The impact is more obvious in more advanced stages of disease and in patients who are difficult to examine clinically due to, for example body constitution. The result of MRI is also an aid in deciding whether or not a fertility preserving operation is feasible

  9. Diagnosis and surgical therapy of uterine sarkoma

    Directory of Open Access Journals (Sweden)

    La?evi? N.N.

    2006-01-01

    Full Text Available Introduction: Uterine sarcomas are rare gynecological neoplasms and their classification is complicated. Uterine sarcoma is usually diagnosed in postmenopausal women and the diagnosis is often accidental and postoperative. Aim of this study was to present clinical and pathological characteristics of uterine sarcomas, diagnostic procedures, treatment and two-, three- and five-years cumulative survival rates. Materials and methods: The retrospective study of 61 cases of uterine sarcomas was conducted. Cases were distributed into groups based on definitive diagnosis of uterine sarcoma: group of leiomyosarcomas (LMS, carcinosarcoma (CS, endometrial stromal sarcomas (ESS, adenosarcomas (AS and other rare uterine sarcomas. We investigated patients with clinical and pathological characteristics of uterine sarcomas, diagnostic procedures and treatment. Survival rate was calculated by Kaplan-Meier method. Results: From 61 patients 43 patients (70.49% were postmenopausal. Mean period from menopause until appearance of symptoms was 14,63 years. One or more risk factors were present in 46 (75.4% patients. Diagnosis of uterine sarcoma were established averagely 7.38 months after appearance of symptoms. 50 patients (82.0% underwent one or more diagnostic procedures. Preoperative diagnosis of uterine sarcoma was established in 42.5% of patients. 53 (86.9% of patients were treated operatively. The most used operative procedure (60,7% was total hysterectomy with bilateral salpingooophorectomy. Postoperative pathohistologic analysis showed that low grade (LG leiomyosarcoma were present in 19 (35.9% cases, high grade (HG leiomyosarcoma in 1 (1.9% case, carcinosarcoma in 14 (26.4% cases, low grade (LG endometrial stromal sarcoma in 5 (9.4% cases, high grade (HG endometrial stromal sarcoma in 9 (17.0% cases, adenosarcoma in 2 (3.8% cases, and 2 cases of rare uterine sarcomas: 1 (1.9% MALT HG lymphoma and 1(1.9% malignant hemangiopericytoma. In one case of ESS (1.9% only adenomyosis was found postoperatively suggesting that the whole tumour was removed during diagnostic procedure. Eight patients were not treated operatively. Two-years cumulative survival rate was 74.3%, three-years cumulative survival rate was 71.1%, and five years survival rate was 64.3%. Discussion: Average age, percent of postmenopausal patients and the mean age at the time of menopause in our studied correlate with current data. Clinical presentation of uterine sarcoma is associated with obesity and hypertension in more than 30% of cases, which is approved in our study. For early diagnostics it is important to notice that risk factors are similar to those connected with far more frequent endometrial carcinoma. Postmenopausal abnormal bleeding was the main reason for medical examination, explaining relatively short period for establishing the diagnosis in this group of patients. The variety of clinical findings in our studied group showed that the diagnosis must be based on preoperative pathohistology. Conclusion: Adequate diagnosis and treatment of uterine sarcoma is possible with regular yearly or more frequent follow-up, especially in postmenopausal women with known risk factors present. We need special attention for unclear symptoms and postmenopausal bleeding and we need to use all diagnostic procedures soon as possible including preoperative histology because early metastases are characteristic for uterine sarcomas. Factor of the most important predictive value is histologic grade. .

  10. Cervical osteophyte induced dysphagia

    International Nuclear Information System (INIS)

    Although cervical spondylosis is a common disorder, dysphagia induced by osteophyte formation is uncommon. Fewer than one hundred cases of cervical osteophyte induced dysphagia have been reported, with little attention to the diagnosis by barium swallow. The radiological features of two cases treated surgically with good results are described. Both cases complained of dysphagia while one had associated respiratory obstruction on forward flexion of his neck. The features on barium study of cervical osteophytes causing dysphagia include deformity at the level of osteophyte formation, in both AP and lateral projections. Tracheal aspirations due to deformity at the laryngeal inlet and interference with epiglottic retroversion may be present. 8 refs., 3 figs

  11. MRI and PET Imaging in Predicting Treatment Response in Patients With Stage IB-IVA Cervical Cancer

    Science.gov (United States)

    2015-11-03

    Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Squamous Cell Carcinoma; Cervical Undifferentiated Carcinoma; Recurrent Cervical Carcinoma; Stage IB Cervical Cancer; Stage IIA Cervical Cancer; Stage IIB Cervical Cancer; Stage IIIA Cervical Cancer; Stage IIIB Cervical Cancer; Stage IVA Cervical Cancer

  12. Uterine biology in pigs and sheep

    Directory of Open Access Journals (Sweden)

    Bazer Fuller W

    2012-07-01

    Full Text Available Abstract There is a dialogue between the developing conceptus (embryo-fetus and associated placental membranes and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling, implantation, regulation of gene expression by uterine epithelial and stromal cells, placentation and exchange of nutrients and gases. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph required for growth and development of the conceptus and receptivity of the uterus to implantation. Pregnancy recognition signaling mechanisms sustain the functional lifespan of the corpora lutea (CL which produce progesterone, the hormone of pregnancy essential for uterine functions that support implantation and placentation required for a successful outcome of pregnancy. It is within the peri-implantation period that most embryonic deaths occur due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. With proper placentation, the fetal fluids and fetal membranes each have unique functions to ensure hematotrophic and histotrophic nutrition in support of growth and development of the fetus. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. This review addresses the complexity of key mechanisms that are characteristic of successful reproduction in sheep and pigs and gaps in knowledge that must be the subject of research in order to enhance fertility and reproductive health of livestock species.

  13. Sets resilient to erosion

    OpenAIRE

    Pegden, Wesley

    2011-01-01

    The erosion of a set in Euclidean space by a radius r>0 is the subset of X consisting of points at distance >/-r from the complement of X. A set is resilient to erosion if it is similar to its erosion by some positive radius. We give a somewhat surprising characterization of resilient sets, consisting in one part of simple geometric constraints on convex resilient sets, and, in another, a correspondence between nonconvex resilient sets and scale-invariant (e.g., 'exact fractal') sets.

  14. Steroidal regulation of uterine resistance to bacterial infection in livestock

    OpenAIRE

    Lewis Gregory S

    2003-01-01

    Abstract Postpartum uterine infections reduce reproductive efficiency and have significant animal welfare and economic consequences. Postpartum uterine infections are classified as nonspecific, but Arcanobacterium pyogenes and Escherichia coli are usually associated with them in cattle and sheep. Pyometra is the most common type of uterine infection in dairy cattle, and it is detected almost exclusively in cows with active corpora lutea. Luteal progesterone typically down-regulates uterine im...

  15. Placenta accrete treated with uterine arterial embolization (case report)

    International Nuclear Information System (INIS)

    Objective: To investigate the possibility of interventional treatment of placenta accrete. Methods: One patient with placenta accrete was treated with uterine arterial infusion of cef and MTX followed by embolization. Results: Her placenta discharged through vagina at the 27 th day after uterine arterial embolization. No remnant was found in the uterine by Doppler imaging. The patient uneventfully recovered. Conclusions: Interventional therapy with uterine arterial embolization is a new and reliable method for treatment for placenta accrete

  16. Uterine vascular lesions: a rare cause of abnormal uterine bleeding, reporting of two cases

    Directory of Open Access Journals (Sweden)

    Sunita Arora

    2014-06-01

    Full Text Available Uterine vascular lesions in the form of arteriovenous malformation or pseudo aneurysm are rare but potential life-threatening source of bleeding. A high index of suspicion and accurate diagnosis of the condition in a timely manner are essential because instrumentation that is often used for other causes of uterine bleeding can lead to massive hemorrhage. We describe two cases of uterine vascular malformation, one presenting as postabortal hemorrhage and other as postpartum hemorrhage. Case one presented as postabortal hemorrhage after induced abortion following dilatation and curettage. Case two presented as delayed postpartum hemorrhage after six weeks following cesarean section. In both cases diagnosis of uterine arteriovenous malformation was made on Doppler ultrasonography which was subsequently confirmed on pelvic angiography. The embolization of affected uterine arteries was performed successfully in both cases. Uterine vascular lesion should be suspected in patient with abnormal vaginal bleeding, especially who has recent medical history of induced abortion or dilatation and curettage or cesarean section and so on. Although angiography remains the gold standard for making diagnosis, Doppler ultrasonography is also a good noninvasive technique for the same. Uterine artery embolization offers a safe and effective treatment. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 749-753

  17. Uterine arterial methotrexate infusion and embolization in the treatment of uterine adenomyosis

    International Nuclear Information System (INIS)

    Objective: To study the efficacy of treating different types of uterine adenomyosis with transcatheter local infusion of methotrexate (MTX) combined with uterine arterial embolization under guidance of digital subtraction angiography (DSA). Methods: 33 cases were primarily screened out according to clinical symptoms and color Doppler and then further diagnosis as diffuse or local adenomyosis were undertaken with super selective uterine arterial angiography. The patients were then treated with uterine arterial local infusion (50 mg MTX)and embolization with PVA microsphere (diameter 450-650 ?m), individually. Finally, the comparison between the preoperative and postoperative menstruation volumes, the degrees of dysmenorrheal, uterine sizes and the levels of sexual hormones of diffuse and local adenomyosis was carried out. Results: The uterine arterial local infusion of MTX combined with embolization showed no chemotherapeutic side effects. In all cases, there were decrease of menstruation amount, alleviated dysmenorrhea, reduction of uterine size, and the efficacy was more evident in diffuse adenomyosis (P<0.05). Conclusions: Micro-invasive interventional technique combined with drug therapy is promising for diffuse and local adenomyosis especially for the former. (authors)

  18. Effects on the equine endometrium of cervical occlusion after insemination.

    Science.gov (United States)

    Reilas, Tiina; Rivera Del Alamo, Maria Montserrat; Liepina, Evija; Yeste, Marc; Katila, Terttu

    2016-03-01

    Cervical patency is considered to be important for uterine drainage after mating or artificial insemination (AI), and failure to relax or premature tightening of the cervix can lead to persistent endometritis. This study investigated the hypothesis that cervical occlusion after AI increases accumulation of fluid, polymorphonuclear leukocytes (PMNs), and cytokines in the uterine lumen. Endometrial swabs were obtained from 29 normal cyclic mares during the first, third, and fifth estrus and biopsies during the first and fifth estrus. All mares were inseminated during the second and fourth estrus. In either the second or fourth estrus, a clamped catheter was inserted into the uterus immediately after AI. Accumulation of intrauterine fluid was evaluated by transrectal ultrasonography at 0, 6, 25, and 48 hours. Fluid was drained from the catheter at either 25 hours (TxA) or 6 and 25 hours after AI (TxB). In the control estrus (TxC, no catheters), fluid was obtained by a tampon at 25 hours after AI. The uteri were then lavaged with Ringer's solution, after which the catheters were withdrawn. Sequences of treatments in the second and fourth estrus were A followed by C, C followed by A, B followed by C, and C followed by B in groups AC, CA, BC, and CB, respectively. Five mares lost their catheters and were excluded from the study. Scores for total inflammation, gland dilation, and lymphatic lacunae in the uterine biopsies did not differ significantly between groups or estrous periods. In contrast, periglandular fibrosis scores increased in all groups during the experiment. At 25 hours after AI in the second estrus, the mares with the catheters had larger accumulations of fluid (P insemination results in pronounced inflammation of the mare's endometrium. Furthermore, this kind of severe insult may lead to permanent pathologic changes in the endometrium, including fibrosis. PMID:26586278

  19. Cervical Cancer Screening

    Science.gov (United States)

    ... douching, sexual intercourse, and using vaginal medications or hygiene products for 2 days before your test. You also should not have cervical cancer screening if you have your menstrual period. Glossary Biopsy: A minor surgical procedure to ...

  20. Immunotherapy for Cervical Cancer

    Science.gov (United States)

    In an early phase NCI clinical trial, two patients with metastatic cervical cancer had a complete disappearance of their tumors after receiving treatment with a form of immunotherapy called adoptive cell transfer.

  1. Cervical Cancer Screening

    Science.gov (United States)

    ... the place where a baby grows during pregnancy. Cancer screening is looking for cancer before you have any ... found early may be easier to treat. Cervical cancer screening is usually part of a woman's health checkup. ...

  2. Vaccinating against cervical cancer

    OpenAIRE

    Jane Parry

    2007-01-01

    Since last year, it has become possible to vaccinate against the human papillomavirus (HPV) that causes most cases of cervical cancer, but countries face tough decisions before making the vaccine widely available.

  3. Sodium cavitation erosion testing

    International Nuclear Information System (INIS)

    This paper discusses the consideration leading to the definition and execution of sodium cavitation erosion tests, and describes the first two tests run with 4000C sodium in the cavitation tunnel at the CADARACHE Nuclear Research Center

  4. Giant Uterine Leiomyoma. A Case Report

    Directory of Open Access Journals (Sweden)

    Luis Noel Marrero Quiala

    2014-09-01

    Full Text Available Giant uterine fibromyoma is a benign condition which has a very low incidence. Its management poses a challenge for the surgical team due to the volume of the surgical specimen and the variations in the distribution of the intra-abdominal organs caused by the uterine growth. The case of a 29-year-old patient misdiagnosed with giant hepatomegaly at admission is presented. Her symptoms included hard abdomen and feeling of heaviness. Successful completion of the interview, physical examination and imaging studies led to the correct diagnosis of giant uterine fibromyoma. Surgical treatment was applied. A total abdominal hysterectomy was performed with satisfactory results. This case is presented to the medical community for teaching purposes and due to its rarity.

  5. Giant Uterine Fibromyoma. A Case Report

    Directory of Open Access Journals (Sweden)

    Tahiluma Santana Pedraza

    2013-12-01

    Full Text Available The uterus is the common site for multiple benign and malignant conditions. Giant uterine fibromyoma is a benign tumor of low incidence. Its management poses a challenge for the surgical team because of the volume of the surgical specimen and the variations in the distribution of intra-abdominal organs caused by uterine growth. A case of a 43-year-old patient with a history of bronchial asthma and hypertension who presented with enlargement of the abdomen and vaginal bleeding is reported. The patient was attended by the General Surgery Department of the María Genoveva Guerrero Ramos Comprehensive Diagnostic Center in the Libertador Municipality, Capital District, Venezuela. Total abdominal hysterectomy and complementary appendectomy were performed. The histopathological study showed a giant uterine fibromyoma. Postoperative progress was satisfactory. It was decided to present the case due to its rarity.

  6. Contrast enhancement versus vasculature of uterine tumors

    International Nuclear Information System (INIS)

    The relativ contrast enhancement of normal myometrium and small or medium size uterine fibroids and clinical stage I endometrial carcinomas were correlated to their microangiographically demonstrable vascularity. In four cases small uterine fibroids showed contrast enhancement equal to normal myometrium, independent of their vascularity in microangiography. In five, endometrial carcinomas contrast enhancement was always below that of the surrounding myometrium in CT. Intratumour vasculature showed great variability in microangiography. No correlation between the topographic variations in the arrangement or density of tumour blood vessels and the degree of contrast enhancement was found. Contrast enhancement of small uterine fibroids was greater than that of small adenocarcinomas. More contrast material accumulates into the extravascular space of the smooth muscle tissue of the fibroid than into the extravascular space of endometrial carcinoma. (orig.)

  7. Erosion control of earthworks

    OpenAIRE

    Reiffsteck, P.

    2004-01-01

    Understanding the factors that control superfical stability od eartworks is essential to limit the transport of particles detached by storms. For that, it would be extremely useful to be able, at an early stage of project, knowing the texture of the soil, to foresee its sensitivity to erosion, inorder to choose another type of fill or to anticipate adapted anti-erosive techniques installation. The study presented here, based on laboratory tests with a mobile water jets test apparatus tries to...

  8. Smoking and Cervical Cancer

    OpenAIRE

    José Alberto Fonseca-Moutinho

    2011-01-01

    Cervical cancer (CC) is the third most common cancer in women worldwide; however, CC is a preventable disease, and much effort should be done to prevent it. Persistence of high-risk HPV infection is the strongest epidemiologic risk factor for CC, however it is not sufficient for development of the disease it cofactors should be present. In 2004; IARC listed cervical cancer among those causally related to smoking. Smoking interferes with incidence and prevalence of HPV infection and is associa...

  9. Ovarian and cervical cancer.

    OpenAIRE

    Williams, C

    1992-01-01

    Death rates from cervical cancer have already fallen this century and for patients with invasive cervical cancer five year survival rates are greater than for most solid tumours. Better screening for premalignant changes may further reduce the incidence of invasive cancer; indeed, it has been claimed that the reduction in mortality could be as high as 90%, though estimates of screening efficacy have varied greatly. For those with advanced invasive carcinoma neoadjuvant chemotherapy may reduce...

  10. Sexually Transmitted Cervicitis

    OpenAIRE

    Romanowski, Barbara

    1989-01-01

    Cervical infections with Neisseria gonorrhoeae, Chlamydia trachomatis, and Herpes simplex virus are some of the most common sexually transmitted infections. They are often asymptomatic, and therefore the patient is at risk of developing complications, such as pelvic inflammatory disease. It is important to recognize cervicitis, investigate it appropriately, and provide early treatment. Sexual partners must also be located and offered therapy to prevent re-infection in the index patient.

  11. CERVICAL NECROTIZING FASCIITIS

    OpenAIRE

    G. Dimofte; Gabriela Lozneanu; Pieptu, D; R. Moldovanu; Danciu, M.; E Târcoveanu

    2009-01-01

    Cervical necrotizing fasciitis is an unusual encounter in the general surgical practice, but is a life-threatening condition requiring early recognition and adequate surgical treatment. We present the case of a 65 year old male patient referred to our department from a General Hospital. Large excisions of both superficial and deep cervical fascia were required together with necrotic skin on a very large surface. Rapid recovery with early sterilization allowed adequate skin grafting with good ...

  12. Comparative study of saline infusion sonography and hysteroscopy for evaluation of uterine cavity in abnormal uterine bleeding

    OpenAIRE

    Sowjanya Nallapati; P Pallavee; Seetesh Ghose

    2015-01-01

    Background: Intra-cavitary uterine pathology is the commonest cause of abnormal uterine bleeding. Hysteroscopy is considered as the gold standard for uterine cavity examination. However, in resource limited set-ups saline infusion sonography is an effective alternative to hysteroscopy. The current study aims to compare the accuracy of saline infusion sonography with hysteroscopy in identifying intra-cavitary lesions in women with abnormal uterine bleeding. Methods: 52 patients with abnorma...

  13. Numerical modelling of concentrated leak erosion during Hole Erosion Tests

    OpenAIRE

    Mercier, F.; Bonelli, S.; F. Golay; Anselmet, F.; Philippe, P.; Borghi, R.

    2014-01-01

    This study focuses on the numerical modelling of concentrated leak erosion of a cohesive soil by a turbulent flow in axisymmetrical geometry, with application to the Hole Erosion Test (HET). The numerical model is based on adaptive remeshing of the water/soil interface to ensure accurate description of the mechanical phenomena occurring near the soil/water interface. The erosion law governing the interface motion is based on two erosion parameters: the critical shear stress and the erosion co...

  14. Human papillomavirus types 16 and 18 in adenocarcinoma of the uterine cervix

    International Nuclear Information System (INIS)

    Many reports have shown a link between human papillomavirus (HPV) and cervical squamous neoplasia. However, the association of HPV with cervical adenocarcinoma has been studied less extensively. The authors evaluated the presence of HPV-DNA in 106 patients with adenocarcinoma of the uterine cervix by in situ hybridization, using 35S-labeled probes for HPV 16 DNA and HPV 18 DNA. The overall prevalence of HPV-DNA was 18% (19 of 106). HPV 16 was present in 2 (2%) cases, HPV 18 was observed in 15 (14%) cases, and both HPV 16 and HPV 18 were found in 2 (2%) cases. There was a correlation between HPV-DNA positivity and tumor stage (P less than 0.01) and tumor size (P less than 0.05), but there was no relationship between HPV-DNA positivity and tumor differentiation, proliferation (S-phase fraction), ploidy, lymph node metastases, or five-year survival rate. These results suggest that HPV 18 DNA is associated with cervical adenocarcinoma but the presence of HPV 18 has no influence on overall survival

  15. Assessment of dose distribution at uterine cervix and surrounding organs in high dose rate brachytherapy of uterine cervical cancer

    International Nuclear Information System (INIS)

    Computational and experimental dosimetry of Henschke applicator with respect to high dose rate brachytherapy using a remote control after loader is performed. A comparison of computational dosimetry is made between the simulated Monte Carlo dosimetry and GAMMADOT brachytherapy planning system's dosimetry. Dose measurements of the performance involve using ion chamber in a water phantom. Dose rates are calculated using Monte Carlo code MCNP4B and the GAMMADOT. The computational models include the detailed geometry of Ir-192 source, tandem tube, and shielded ovoids for accurate estimation. And transit dose delivered during source extension to and retraction from a given dwell position is estimated by Monte Carlo simulations. Point doses at ICRU bladder/rectal points which have been recommended by ICRU 38 is assessed. Calculated and measured dose distribution data agreed within 4% each other. The shielding effect of avoids leads to 19% and 20% dose reduction at bladder surface and rectal points

  16. Assessment of dose distribution at uterine cervix and surrounding organs in high dose rate brachytherapy of uterine cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yun Jong

    2003-02-15

    Computational and experimental dosimetry of Henschke applicator with respect to high dose rate brachytherapy using a remote control after loader is performed. A comparison of computational dosimetry is made between the simulated Monte Carlo dosimetry and GAMMADOT brachytherapy planning system's dosimetry. Dose measurements of the performance involve using ion chamber in a water phantom. Dose rates are calculated using Monte Carlo code MCNP4B and the GAMMADOT. The computational models include the detailed geometry of Ir-192 source, tandem tube, and shielded ovoids for accurate estimation. And transit dose delivered during source extension to and retraction from a given dwell position is estimated by Monte Carlo simulations. Point doses at ICRU bladder/rectal points which have been recommended by ICRU 38 is assessed. Calculated and measured dose distribution data agreed within 4% each other. The shielding effect of avoids leads to 19% and 20% dose reduction at bladder surface and rectal points.

  17. Radiation Therapy Plus Cisplatin and Gemcitabine in Treating Patients With Cervical Cancer

    Science.gov (United States)

    2014-12-23

    Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Small Cell Carcinoma; Cervical Squamous Cell Carcinoma; Stage IB Cervical Cancer; Stage IIA Cervical Cancer; Stage IIB Cervical Cancer; Stage III Cervical Cancer; Stage IVA Cervical Cancer

  18. The clinical research for the effects of uterine resection and uterine arterial embolization on the function of ovary

    International Nuclear Information System (INIS)

    Objective: To investigate the effects of uterine resection and uterine arterial embolization on the function of ovary. Methods: The serum concentrations of estrin (E2), progestogen (P), follicle-stimulating hormone (FSH), luteotropic hormone (LH) and prolactin (PRL) were measured in 15 patients with uterine resection and 22 patients with uterine arterial embolization; including 23 patients with uterine leiomyoma and 29 normal women. Authors compared the results of the five hormones in each group. Results: The serum concentrations of E2 and P in the group of uterine resection were lower than the normal control group, there was a significant difference between them. Compared the serum concentrations of E2 and P in the group of uterine arterial embolization and normal control group, there was no significant difference. The serum concentration of PRL in the group of uterine leiomyoma was higher than the normal control group with significant difference. When the uterus was resected or uterine artery was embolized, the serum concentration of PRL decreased remarkably. Conclusions: Uterine resection has effects on the function of ovary, but uterine arterial embolization would not. PRL may be one of the factors causing the formation of uterine leiomyoma

  19. [Cervical fractures in autopsy records].

    Science.gov (United States)

    Pankowski, Rafa?; Wilmanowska, Anita; Gos, Tomasz; Smoczy?ski, Andrzej

    2003-01-01

    We reviewed the autopsy records of 1872 cases of death because of politrauma, gunshot wounds and suicidal hanging. The analysis included causes and frequency of cervical spine fractures, their most common localisation, architecture of bone destruction and their influence on cervical cord. The most common cause of cervical spine injury was motor vehicle accidents. We examined 82 specimens with traumatic fractures of cervical spine obtained from accident victims. About half of the injuries occurred in upper cervical spine. The most common fracture localisation was C2 with dens fracture as the most frequent injury. The most common spinal cord lesion was complete rupture mainly at the upper cervical spine level. PMID:14564791

  20. The cytological diagnosis and prognosis of malignization of cervical epithelium of uterus in pregnant women.

    Directory of Open Access Journals (Sweden)

    Sumenko V.V.

    2007-01-01

    Full Text Available The investigation is dedicated to the study of the pathological alterations of cervical epithelium of uterus, proliferative activity in the lesion focuses and the improvement of cytological diagnosis of the state of cervical epithelium of uterus. The correlation between the proliferative processes in abnormal epithelium of uterine cervix and some pathological factors of the pregnant women organism was studied. The criteria for prognosis of the cervical epithelial dysplasia in pregnant women were elaborated on this basis of our data. The pathological processes in cervical epithelium were revealed in 309 pregnant women in the first trimester (mean age of women was 26,17±0,83 years. The hormonal state of pregnant women was studied on the basis of colpocytological picture and the colpocytological types which indicate the unfavorable prognosis with a certain degree of validity were determined. The mathematic model for all cytological groups of pregnant women for prognosis of inflammatory processes, epithelial dysplasia and preinvasive cervical cancer was created. The simple and comprehensible prognostic scheme for diagnosis of epithelial dysplasia and preinvasive cervical cancer was developed.

  1. Operative Treatment of Cervical Myelopathy: Cervical Laminoplasty

    OpenAIRE

    Donaldson, William F; Chris Cornett; David Lunardini; Brett A. Braly

    2012-01-01

    Cervical spondylotic myelopathy (CSM) is a degenerative process which may result in clinical signs and symptoms which require surgical intervention. Many treatment options have been proposed with various degrees of technical difficulty and technique sensitive benefits. We review laminoplasty as a motion-sparing posterior decompressive method. Current literature supports the use of laminoplasty for indicated decompression. We also decribe our surgical technique for an open-door, or “hinged”, l...

  2. Variation in incidence and outcome of cervical cancer in the Netherlands: Studies based on cancer registry data

    OpenAIRE

    Aa, Maaike Anne

    2008-01-01

    In the Netherlands, approximately 2% of all newly diagnosed malignant tumours in women are cancers of the uterine cervix, corresponding to about 700 new cases of invasive carcinoma per year. A general practitioner sees a patient with newly diagnosed cervical cancer only once in 15 years and this may vary between once in 10 to once in 25 years. Every year about 250 women die from cervical cancer, which is about 1.5% of all deaths in women caused by cancer. However, partly due to the mass scree...

  3. Impact of spontaneous fibroid expulsion of uterine leiomyoma on pregnancy outcome after uterine arteries embolization

    Directory of Open Access Journals (Sweden)

    Medvediev M.V.

    2015-09-01

    Full Text Available Uterine leiomyoma (UL is common benign tumor of female genitals. Uterine artery embolization (UAE is widely used method of organ-sparing UL treatment. Safe ty of this procedure for future fertility and labor is controversial. We present a case of pregnancy in woman who previously underwent uterine artery embolization. During 12-months’ follow-up period patient periodically noted vaginal di¬scharge. No signs of UL have been found on ultrasound in 12 months of follow-up. Normal pregnancy occurred 1.5 years after UAE procedure which ended in normal labor without complications. Most authors report increased risk of pregnancy complications such as postpartum hemorrhage, preterm delivery, malpresentation after UAE. Our point of view is that a lot of pregnancy complications are possibly associated with persistence of necrotic leiomyoma tissue in uterine wall after UAE. Presented case allowed to draw preliminary conclusions that complete disappearance of UL nodule after UAE could improve pregnancy outcomes.

  4. Rainfall Erosivity in Europe

    DEFF Research Database (Denmark)

    Panagos, Panos; Ballabio, Cristiano

    2015-01-01

    Rainfall is one the main drivers of soil erosion. The erosive force of rainfall is expressed as rainfall erosivity. Rainfall erosivity considers the rainfall amount and intensity, and is most commonly expressed as the Rfactor in the USLE model and its revised version, RUSLE. At national and continental levels, the scarce availability of data obliges soil erosion modellers to estimate this factor based on rainfall data with only low temporal resolution (daily, monthly, annual averages). The purpose of this study is to assess rainfall erosivity in Europe in the form of the RUSLE R-factor, based on the best available datasets. Data have been collected from 1541 precipitation stations in all European Union (EU) Member States and Switzerland, with temporal resolutions of 5 to 60 min. The R-factor values calculated from precipitation data of different temporal resolutions were normalised to R-factor values with temporal resolutions of 30 min using linear regression functions. Precipitation time series ranged from a minimum of 5 years to a maximum of 40 years. The average time series per precipitation station is around 17.1 years, the most datasets including the first decade of the 21st century. Gaussian Process Regression (GPR) has been used to interpolate the R-factor station values to a European rainfall erosivity map at 1 km resolution. The covariates used for the R-factor interpolation were climatic data (total precipitation, seasonal precipitation, precipitation of driest/wettest months, average temperature), elevation and latitude/longitude. The mean R-factor for the EU plus Switzerland is 722 MJ mm ha?1 h?1 yr?1, with the highest values (N1000 MJ mm ha?1 h?1 yr?1) in the Mediterranean and alpine regions and the lowest (b500 MJ mm ha?1 h?1 yr?1) in the Nordic countries.

  5. MRI Assessment of Uterine Artery Patency and Fibroid Infarction Rates 6 Months after Uterine Artery Embolization with Nonspherical Polyvinyl Alcohol

    International Nuclear Information System (INIS)

    Purpose: We have observed significant rates of uterine artery patency after uterine artery embolization (UAE) with nonspherical polyvinyl alcohol (nsPVA) on 6 month follow-up MR scanning. The study aim was to quantitatively assess uterine artery patency after UAE with nsPVA and to assess the effect of continued uterine artery patency on outcomes. Methods: A single centre, retrospective study of 50 patients undergoing bilateral UAE for uterine leiomyomata was undertaken. Pelvic MRI was performed before and 6 months after UAE. All embolizations were performed with nsPVA. Outcome measures included uterine artery patency, uterine and dominant fibroid volume, dominant fibroid percentage infarction, presence of ovarian arterial collaterals, and symptom scores assessed by the Uterine Fibroid Symptom and Quality of Life questionnaire (UFS-QOL). Results: Magnetic resonance angiographic evidence of uterine artery recanalization was demonstrated in 90 % of the patients (64 % bilateral, 26 % unilateral) at 6 months. Eighty percent of all dominant fibroids demonstrated >90 % infarction. The mean percentage reduction in dominant fibroid volume was 35 %. No significant difference was identified between nonpatent, unilateral, and bilateral recanalization of the uterine arteries with regard to percentage dominant fibroid infarction or dominant fibroid volume reduction. The presence of bilaterally or unilaterally patent uterine arteries was not associated with inferior clinical outcomes (symptom score or UFS-QOL scores) at 6 months. Conclusion: The high rates of uterine artery patency challenge the current paradigm that nsPVA is a permanent embolic agent and that permanent uterine artery occlusion is necessary to optimally treat uterine fibroids. Despite high rates of uterine artery recanalization in this cohort, satisfactory fibroid infarction rates and UFS-QOL scores were achieved

  6. MRI Assessment of Uterine Artery Patency and Fibroid Infarction Rates 6 Months after Uterine Artery Embolization with Nonspherical Polyvinyl Alcohol

    Energy Technology Data Exchange (ETDEWEB)

    Das, Raj, E-mail: rajdas@nhs.net; Gonsalves, Michael; Vlahos, Ioannis [St George' s Healthcare NHS Trust, Blackshaw, Department of Radiology (United Kingdom); Manyonda, Issac [St George' s Healthcare NHS Trust, Department of Gynaecology (United Kingdom); Belli, Anna-Maria [St George' s Healthcare NHS Trust, Blackshaw, Department of Radiology (United Kingdom)

    2013-10-15

    Purpose: We have observed significant rates of uterine artery patency after uterine artery embolization (UAE) with nonspherical polyvinyl alcohol (nsPVA) on 6 month follow-up MR scanning. The study aim was to quantitatively assess uterine artery patency after UAE with nsPVA and to assess the effect of continued uterine artery patency on outcomes. Methods: A single centre, retrospective study of 50 patients undergoing bilateral UAE for uterine leiomyomata was undertaken. Pelvic MRI was performed before and 6 months after UAE. All embolizations were performed with nsPVA. Outcome measures included uterine artery patency, uterine and dominant fibroid volume, dominant fibroid percentage infarction, presence of ovarian arterial collaterals, and symptom scores assessed by the Uterine Fibroid Symptom and Quality of Life questionnaire (UFS-QOL). Results: Magnetic resonance angiographic evidence of uterine artery recanalization was demonstrated in 90 % of the patients (64 % bilateral, 26 % unilateral) at 6 months. Eighty percent of all dominant fibroids demonstrated >90 % infarction. The mean percentage reduction in dominant fibroid volume was 35 %. No significant difference was identified between nonpatent, unilateral, and bilateral recanalization of the uterine arteries with regard to percentage dominant fibroid infarction or dominant fibroid volume reduction. The presence of bilaterally or unilaterally patent uterine arteries was not associated with inferior clinical outcomes (symptom score or UFS-QOL scores) at 6 months. Conclusion: The high rates of uterine artery patency challenge the current paradigm that nsPVA is a permanent embolic agent and that permanent uterine artery occlusion is necessary to optimally treat uterine fibroids. Despite high rates of uterine artery recanalization in this cohort, satisfactory fibroid infarction rates and UFS-QOL scores were achieved.

  7. Cervical perineural cyst masquerading as a cervical spinal tumor.

    Science.gov (United States)

    Joshi, Vijay P; Zanwar, Atul; Karande, Anuradha; Agrawal, Amit

    2014-04-01

    Tarlov (perineural) cysts of the nerve roots are common and usually incidental findings during magnetic resonance imaging of the lumbosacral spine. There are only a few case reports where cervical symptomatic perineural cysts have been described in the literature. We report such a case where a high cervical perineural cyst was masquerading as a cervical spinal tumor. PMID:24761204

  8. Cervical Perineural Cyst Masquerading as a Cervical Spinal Tumor

    OpenAIRE

    Joshi, Vijay P.; Zanwar, Atul; Karande, Anuradha; Agrawal, Amit

    2014-01-01

    Tarlov (perineural) cysts of the nerve roots are common and usually incidental findings during magnetic resonance imaging of the lumbosacral spine. There are only a few case reports where cervical symptomatic perineural cysts have been described in the literature. We report such a case where a high cervical perineural cyst was masquerading as a cervical spinal tumor.

  9. Intra-uterine hematoma in pregnancy

    DEFF Research Database (Denmark)

    Glavind, K; Nøhr, S; Nielsen, P H; Ipsen, L

    1991-01-01

    In 60 patients with a live fetus and an intra-uterine hematoma (IUH) proven by ultrasonic scanning the outcome of pregnancy was spontaneous abortion in 12% and premature delivery in 10%. No correlation between the outcome of the pregnancy and the maximum size of the hematoma or the week of...

  10. Uterine fibroids - clinical presentation and complications

    Directory of Open Access Journals (Sweden)

    Spari? Radmila

    2014-01-01

    Full Text Available Fibroids are the most common benign tumors of the genital organs in women of childbearing age. In some women, fibroids can be present for years without any symptoms and then are discovered accidentally during a gynecological examination. In others, they can cause significant morbidity and necessitate the need for multiple surgical procedures. The scope of this clinical review is to provide information about the clinical data as well as the complications of uterine fibroids and their clinical presentation. The most common symptoms that may occur in women with uterine fibroids include: bleeding (menometrorrhagia, metrorrhagia or intermenstrual bleeding, pain, symptoms of compression of adjacent structures, changed appearance of the abdomen and infertility. Complications of uterine fibroids include: venous thromboembolism, torsion of pedunculated fibroids, acute urinary retention and renal insufficiency, vaginal and intraabdominal bleeding, mesenteric vein thrombosis and gangrene of the intestine. Complications of uterine fibroids fibroids are rare and though they may cause significant morbidity, and rarely, mortality, which indicates the need for further research in this area. Accurate diagnosis is an essential prerequisite for the evaluation of therapeutic options, especially recently, when medical and numerous non-invasive treatment options have become available.

  11. Histogenesis of lipomatous component in uterine lipoleiomyomas

    Directory of Open Access Journals (Sweden)

    Filiz BOLAT

    2007-05-01

    Full Text Available Uterine neoplasms composed of an admixture of smooth muscle and adipose tissue are rare and have been designated as lipoleiomyomas. The origin of this tumor is stil controversial and it has not been sufficiently studied. The aim of our study was to investigate the immunohistochemical phenotype of fat cells in uterine lipoleiomyomas so as to clarify their origin. Archived tissue samples of 10 uterine lipoleiomyomas were selected and analyzed immunohistochemically for vimentin, desmin, and HMB-45 expression. The patients ranged from 31 to 63 years of age (mean age 53.5±9.9. Seven tumors which affected the uterine corpus, showed intramural location; while two cases were subserosal, and one was in the cervix. All tumors were constituted by irregular bundles of smooth cells and mature large adipose cells. The amount of adipose component varied from 5 to 95% of the tumor mass. Cytological atypia and necrosis were not seen. Immunohistochemical investigations revealed obvious reactivity to vimentin and desmin in perivascular immature mesencyhmal cells and tumoral smooth muscle cells. Adipose cells in the tumors demonstrated uniform vimentin expression and inconsistent desmin immunoreactivity. All adipose cells were negative for HMB-45 antigen. However, HMB-45 antigen was weakly positive in spindle shaped tumor cells of two cases. In our study, the immunohistochemical findings suggest a complex histogenesis for these tumors, which may arise from perivascular immature mesencyhmal cells or direct transformation of smooth muscle cells into adipocytes by means of progressive intracellular storage of lipids.

  12. [Chemotherapy and hormone therapy for uterine sarcomas].

    Science.gov (United States)

    Yamashita, Hiroshi; Arai, Hiroharu; Aoki, Daisuke

    2012-05-01

    Uterine sarcomas are relatively rare mesenchymal malignant neoplasms with poor prognosis, accounting for 8%of all uterine malignant neoplasms. There are only a few moderately active cytotoxic agents for this entity, and therefore, chemotherapy for uterine sarcomas is palliative in most cases. According to traditional classification systems, uterine sarcomas encompass carcinosarcoma(CS), leiomyosarcoma(LMS), and endometrial stromal cell sarcoma(ESS). For carcinosarcoma, ifosfamide, cisplatin, and paclitaxel are reported to be moderately effective single agents. The combination of ifosfamide and cisplatin appeared to improve progression-free survival, but the severe toxicity it induced was not negligible. Paclitaxel and ifosfamide were the only chemotherapy regimen which slightly improved both progression-free and overall survival. For leiomyosarcoma and undifferentiated endometrial sarcoma(formerly named high-grade ESS), doxorubicin, ifosfamide, and gemcitabine are moderately effective single agents. There are several reports showing the effectiveness of gemcitabine plus docetaxel. For endometrial stromal sarcoma(formerly named low-grade ESS), progestins and aromatase inhibitors have been proven beneficial. PMID:22584323

  13. Management of intra uterine growth restriction

    OpenAIRE

    Du Plessis, J.H.; Chauke, H.L.

    2008-01-01

    Intra-uterine growth restriction (IUGR) remains a complex management problem in modern obstetric practise. It is a major cause of perinatal morbidity and mortality in South Africa as well as in the developed world and is a cause of great concern for the patient, her family and doctor.

  14. Cervical Stenosis, Myelopathy and Radiculopathy

    Science.gov (United States)

    ... in certain parts of the arm or leg. Cervical myelopathy refers to a loss of function in the ... between C5 and C6 What are the symptoms? Cervical myelopathy tends to creep up on patients in most ...

  15. Cervical cancer - screening and prevention

    Science.gov (United States)

    Cervical cancer is cancer that starts in the cervix. The cervix is the lower part of the uterus ( ... can do to decrease your chance of having cervical cancer. Also, tests done by your health care provider ...

  16. Spinal surgery -- cervical - series (image)

    Science.gov (United States)

    Cervical spine disease is usually caused by herniated intervertebral discs, abnormal growth of bony processes on the vertebral ... spinal column around the spinal cord. Symptoms of cervical spine problems include: pain that interferes with daily activities ...

  17. Treatment Option Overview (Cervical Cancer)

    Science.gov (United States)

    ... Childhood Treatment . Human papillomavirus (HPV) infection is the major risk factor for cervical cancer. Anything that increases ... to collect cells or tissue from the cervical canal using a curette (spoon-shaped instrument). Tissue samples ...

  18. Doppler indicates of uterine artery Doppler velocimetry by placental location

    Energy Technology Data Exchange (ETDEWEB)

    Han, Sung Shik; Park, Yong Won; Cho, Jae Sung; Kwon, Hye Kyeung; Kim, Jae Wook [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2001-09-15

    Our purpose was to investigate the relation between the vascular resistance of uterine artery and placental location and to establish the reference value of Doppler index in uterine artery by placental location. Placental location and flow velocity waveforms of both uterine arteries in 7,016 pregnant women after 18 weeks gestation were examined using color Doppler ultrasonography. Placental location was classified as central and lateral placental and the uterine artery with lateral placental were divided into ipsilateral uterine artery (same side of the placental) and contralateral uterine artery (opposite side of the placenta). The uterine artery with central placental was classified as the central uterine artery. Systolic-Diastolic ratio (S/D ratio) of uterine arteries by gestational weeks were calculated and compared with the placental location and perinatal outcomes. In the lateral placental group, the S/D ratio of the contralateral uterine artery was higher than the ipsilateral one (mean=2.08+0.34 vs 1.89+0.34, p=0.0001). S/D ratio of the uterine artery decreased during second trimester and the ratio after 27 weeks was a tendency to have a constant values(ipsilateral: 1.85+ 0.34, central : 1.96+ 0.40, contralateral: 2.01+0.54). S/D ratio of the uterine artery was affected by placental location. So when we evaluate Doppler spectrum of uterine artery, placental location should be considered and we established the reference value of Doppler index of uterine artery by placental location.

  19. Detection of Merkel cell polyomavirus in cervical squamous cell carcinomas and adenocarcinomas from Japanese patients

    Directory of Open Access Journals (Sweden)

    Imajoh Masayuki

    2012-08-01

    Full Text Available Abstract Background Merkel cell polyomavirus (MCPyV was identified originally in Merkel cell carcinoma (MCC, a rare form of human skin neuroendocrine carcinoma. Evidence of MCPyV existence in other forms of malignancy such as cutaneous squamous cell carcinomas (SCCs is growing. Cervical cancers became the focus of our interest in searching for potentially MCPyV-related tumors because: (i the major histological type of cervical cancer is the SCC; (ii the uterine cervix is a common site of neuroendocrine carcinomas histologically similar to MCCs; and (iii MCPyV might be transmitted during sexual interaction as demonstrated for human papillomavirus (HPV. In this study, we aimed to clarify the possible presence of MCPyV in cervical SCCs from Japanese patients. Cervical adenocarcinomas (ACs were also studied. Results Formalin-fixed paraffin-embedded tissue samples from 48 cervical SCCs and 16 cervical ACs were examined for the presence of the MCPyV genome by polymerase chain reaction (PCR and sequencing analyses. PCR analysis revealed that 9/48 cervical SCCs (19% and 4/16 cervical ACs (25% were positive for MCPyV DNA. MCPyV-specific PCR products were sequenced to compare them with reference sequences. The nucleotide sequences in the MCPyV large T (LT-sequenced region were the same among MCPyV-positive cervical SCCs and AC. Conversely, in the MCPyV viral protein 1 (VP1-sequenced region, two cervical SCCs and three cervical ACs showed several nucleotide substitutions, of which three caused amino acid substitutions. These sequencing results suggested that three MCPyV variants of the VP1 were identified in our cases. Immunohistochemistry showed that the LT antigen was expressed in tumor cells in MCPyV-positive samples. Genotyping of human HPV in the MCPyV-positive samples revealed that infected HPVs were HPV types 16, 31 and 58 for SCCs and HPV types 16 and 18 for ACs. Conclusions This study provides the first observation that MCPyV coexists in a subset of HPV-associated cervical cancers from Japanese patients. The prevalence of MCPyV in these lesions was close to that observed in the cutaneous SCCs. Further worldwide epidemiological surveys are warranted to determine the possible association of MCPyV with pathogenesis of cervical cancers.

  20. Deep cervical infection?

    Directory of Open Access Journals (Sweden)

    Bernardo T

    2012-06-01

    Full Text Available Introduction: Inflammatory cervical swelling may have several causes. The jugular vein thrombosis is a rare entity, often forgotten. Most frequently arises due to a cervical sepsis by the use of a central venous catheter or intravenous drug abuse (drug addicts. Rarely, is secondary to a hypercoagulability state associated with a visceral carcinoma (Trousseau Syndrome. Material and Methods: The authors present the case of a 65 years old male, who used the ENT Emergency Service due to a painful left cervical swelling with local and systemic inflammatory signs of 3 days duration. Results: An cervical ultrasound suggested a neck abscess. CT was performed and confirmed the ultrasound results. Because of its location in the path of the internal jugular vein, we requested re-evaluation by CT with intravenous contrast and doppler ultrasound, obtaining the diagnosis of thrombosis of the internal jugular vein. Further studies were conduct to clarify the hypercoagulability state, since the patient had no known predisposing factor. Finally the diagnosis of unresectable gastric carcinoma was made. Discussion and Conclusion: The ENT must be aware and be able to understand any cervical imagiologic studies. A deep knowledge of the anatomical imagiología is important for the diagnosis of jugular thrombosis. When we have a case of spontaneous jugular thrombosis, we must look for possible visceral carcinoma.