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Sample records for uterine cervical erosion

  1. Carbon ion therapy for uterine cervical cancer

    International Nuclear Information System (INIS)

    Between June 1995 and August 2003, the four phase I/II dose escalation studies of carbon ion radiotherapy for locally advanced uterine cancer have been performed. Forty-four patients received carbon ion radiotherapy in 24 fixed fractions over 6 weeks (9403 and 9702) and 36 patients received in 20 fixed fractions over 5 weeks (9704 and 9902). The median tumor size in this population was 6.5 cm in diameter. In the beginning of these studies, 8 patients developed grade 4 late morbidity of the rectum and sigmoid colon. These patients underwent colostomy and they are all alive with disease free except one local recurrence. The technique of cone down irradiation to the primary lesion was improved and now there are no severe morbidity in the rectum and sigmoid colon. On the other hand, the tumor control rate increased as the total dose was escalated. The overall local control rate were 71% and 63% at 5 year for stage IIIB and IVA cervical squamous cell carcinoma, and 54% at 4 year for stage III and IVA cervical adenocarcinoma. Carbon ion radiotherapy is considered to be effective for the bulky squamous cell carcinoma and adenocarcinoma which are hard to cure in conventional radiotherapy. (author)

  2. Radiotherapy for postoperative recurrent uterine cervical carcinoma

    International Nuclear Information System (INIS)

    From January 1980 to December 1985, a total of 110 patients with postoperative recurrent uterine cervical carcinoma were treated with radiotherapy. The mean age was 53 years. Ten patients were excluded due to incomplete treatment. The population was grouped according to the classification by Ciatto et al. into patients with central recurrence (n=48), with peripheral limited recurrence (n=43), and with peripheral massive recurrence (n=9). The midpelvic dose given to patients with central recurrence was 40 to 45 Gy, followed by a boost given either by perineal teletherapy with 30 Gy or brachytherapy with 30 Gy at 0.5 cm beneath the vaginal mucosa. For the peripheral group, the midpelvic dose was 50 Gy followed by a boost of 10 Gy through reduced portals. Further boost to the vaginal mucosa was given by either of the two methods mentioned above. The overall 5-year survival rate was 28%. In the group with central recurrence, it was 42% and in the group with peripheral recurrence 15%. Sixteen patients had persistent local tumor and 15 patients developed distant metastasis. Complications noted were proctitis (5%), cystitis (2%), vesicovaginal fistula (2%) and rectovaginal fistula (2%). Our data clearly indicate that radiotherapy was effective in controlling central recurrence, but for peripheral recurrence, control rate and prognosis were less favorable. (orig.)

  3. A Case of Uterine Cervical Cancer Presenting with Granulocytosis

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    Ahn, Heui June; Park, Yeon Hee; Chang, Yoon Hwan; Park, Sun Hoo; Kim, Min-Suk; Ryoo, Baek Yeol; Yang, Sung Hyun

    2005-01-01

    Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients with renal cell carcinoma. Granulocytosis occurs because of production of G-CSF, GM-CSF and IL-6. Uterine cervical carcinoma with granulocytosis as a paraneoplastic syndrome, however, has been rarely reported. We recently witnessed a case of invasive squamous cell carcinoma of the uterine cervix with granul...

  4. Short-course palliative radiotherapy for uterine cervical cancer

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    Kim, Dong Hyun; Lee, Ju Hye; Ki, Yong Kan; Kim, Won Taek; Park, Dahl; Kim, Dong Won [Dept. of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital, Busan (Korea, Republic of); Nam, Ji Ho; Jeon, Sang Ho [Dept. of Radiation Oncology, Pusan National University Yangsan Hospital, Yangsan (Korea, Republic of)

    2013-12-15

    The purpose of this retrospective study was to evaluate the efficacy and feasibility of short-course hypofractionated radiotherapy (RT) for the palliation of uterine cervical cancer. Seventeen patients with cancer of the uterine cervix, who underwent palliative hypofractionated 3-dimensional conformal radiotherapy between January 2002 and June 2012, were retrospectively analyzed. RT was delivered to symptomatic lesions (both the primary mass and/or metastatic regional lymph nodes). The total dose was 20 to 25 Gy (median, 25 Gy) in 5 Gy daily fractions. The median follow-up duration was 12.2 months (range, 4 to 24 months). The median survival time was 7.8 months (range, 4 to 24 months). Vaginal bleeding was the most common presenting symptom followed by pelvic pain (9 patients). The overall response rates were 93.8% and 66.7% for vaginal bleeding control and pelvic pain, respectively. Nine patients did not have any acute side effects and 7 patients showed minor gastrointestinal toxicity. Only 1 patient had grade 3 diarrhea 1 week after completion of treatment, which was successfully treated conservatively. Late complications occurred in 4 patients; however, none of these were of grade 3 or higher severity. Short-course hypofractionated RT was effective and well tolerated as palliative treatment for uterine cervical cancer.

  5. Uterine cervical cancer with brain metastasis as the initial site of presentation.

    Science.gov (United States)

    Sato, Yumi; Tanaka, Kei; Kobayashi, Yoichi; Shibuya, Hiromi; Nishigaya, Yoshiko; Momomura, Mai; Matsumoto, Hironori; Iwashita, Mitsutoshi

    2015-07-01

    Brain metastasis from uterine cervical cancer is rare, with an incidence of 0.5%, and usually occurs late in the course of the disease. We report a case of uterine cervical cancer with brain metastasis as the initial site of presentation. A 50-year-old woman with headache, vertigo, amnesia and loss of appetite was admitted for persistent vomiting. Contrast enhanced computed tomography showed a solitary right frontal cerebral lesion with ring enhancement and uterine cervical tumor. She was diagnosed with uterine cervical squamous cell carcinoma with parametrium invasion and no other distant affected organs were detected. The cerebral lesion was surgically removed and pathologically proved to be metastasis of uterine cervical squamous cell carcinoma. The patient underwent concurrent chemoradiotherapy, followed by cerebral radiation therapy, but multiple metastases to the liver and lung developed and the patient died 7?months after diagnosis of brain metastasis. PMID:25656985

  6. Air in vagina: significance in the staging of uterine cervical carcinoma

    International Nuclear Information System (INIS)

    To evaluate the significance of vaginal air seen on CT scan in preoperative staging of uterine cervical carcinoma. A comparison was made between CT findings of vaginal fir and true vaginal involvement status in 85 patients with uterine cervical carcinoma. CT findings were analyzed in terms of the presence or absence of vaginal air, number of CT slices in which vaginal air was seen, shape of vaginal air, and relation of vaginal air to cervical mass. Vaginal air was present in 35 patients and was absent in 50. Although the mere presence of vaginal air or multiplicity of CT slices showing vaginal air did not signify the presence of vaginal involvement, vaginal air with irregular margin or vaginal air adjacent to uterine cervical mass was suggestive of vaginal involvement. These observation of vaginal air in interpreting CT may be helpful in the preoperative staging of uterine cervical carcinoma

  7. EARLY POSTOPERATIVE OUTCOMES IN PATIENTS WITH UTERINE CERVICAL CANCER

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    M?d?lina Gavrilescu

    2013-09-01

    Full Text Available BACKGROUND: Uterine cervical cancer still presents high percentages of locally advanced tumors on diagnosis due to the lack of screening programs. The multidisciplinary approach in these cases requires neoadjuvant radio-chemotherapy followed in selected cases by surgery. The aim of this study was the assessment of early postoperative outcomes in a consecutive series of cervical cancer patients. METHODS: We performed a comparative analysis in terms of patients and tumor characteristics, type of surgery and postoperative complications on 83 patients with radical surgery divided in terms of neoadjuvant treatment protocol. Two groups were designed: group A, patients who underwent neoadjuvant therapy (n=38; 45.78% and group B, patients operated without neoadjuvant therapy (n=45; 54.22%. RESULTS: The patients mean age was 54.1±11.6 years old. Most cases on diagnosis were stage IIB (41 cases, 49.39% followed by stage IB (24 cases, 28.9%. Neoadjuvant treatment was performed in 38 patients (45.78% (stage IIA – 1 patient, IIB – 31 patients, IIIA – 1 patient and IIIB – 5 patients, with a complete response in 16 (42.1%. Most common intervention was type II radical hysterectomy with pelvic lymphadenectomy in 54 cases (65%. There was no difference in terms of deep vein thrombosis, postoperative urinary and medical morbidity. Digestive complications were relatively higher in neoadjuvant group (28.94% in group A vs. 6.66% in group B, P=0.008 with a longer hospitalization (8.1±2.7 days for group A vs. 6.6±1.6 for group B, P=0.01. CONCLUSION: Radical hysterectomy is a relatively safe technique in terms of postoperative morbidity for patients with cervical cancer despite the use of neoadjuvant therapy. This provides the chance for cure in early stages and a local control for more advanced cases.

  8. Radiotherapy results for recurrent uterine cervical cancer after surgery

    International Nuclear Information System (INIS)

    To evaluate prognostic factors and survival rates of the patients who received radiation therapy for locally recurrent uterine cervical cancer after curative surgery. Between October 1983 and July 1996, fifty three patients who received radiation therapy for locally recurrent cervical cancer after curative surgery at the Department of Therapeutic Radiology, Kangnam St. Mary's Hospital, The Catholic University of Korea were analysed retrospectively. Age at diagnosis ranged from 33 to 69 years (median 53 years). Pathological analysis showed that forty five (84.9%) patients had squamous cell carcinoma, seven (13.2%) patients had adenocarcinoma, and one (1.9%) patient had adenosquamous cell carcinoma. The interval between hysterectomy and tumor recurrence ranged from 2 months to 25 years (mean 34.4 months). The recurrent sites were vaginal stump in 41 patients (77.4%) and pelvic side wall in 12 patients (22.6%). Recurrent tumor size was divided into two groups: less than 3 cm in 43 patients (81.1%) and more than 3 cm in 10 patients (18.9%). External beam irradiation of whole pelvis was done first up to 46.8 Gy to 50.4 Gy in 5 weeks to 6 weeks, followed by either external beam boost to the recurrent site in 18 patients (34%) or intracavitary irradiation in 24 patients (45.3%). Total dose of radiation ranged from 46.8 Gy to 111 Gy (median 70.2 Gy). Follow up period ranged from 2 to 153 months with a median of 35 months. Overall response rate was 66% (35/53). Among them, sixonse rate was 66% (35/53). Among them, six patients (17.1%) relapsed between 7 months and 116 months after radiation therapy (mean 47.7 months). Therefore overall recurrence rate was 45.3%. Overall five-year actuarial survival rate was 78.9% and distant failure rate was 10% (5/50). The significant prognostic factors affecting survival rate were interval between primary surgery and tumor recurrence (p=0.0055), recurrent tumor size (p=0.0039), and initial response to radiation therapy (p=0.0428). Complications were observed in 10 (20%) patients, which included mild to moderate lower gastrointestinal, genitourinary, or skin manifestations. One patient died of pulmonary embolism just after intracavitary irradiation. Radiation therapy is the effective treatment for the patients with locally recurrent cervical cancer after curative surgery. These results suggest that interval between primary surgery and tumor recurrence, recurrent tumor size, and initial response to radiation therapy were significant prognostic factors for recurrent cervical cancer

  9. High-dose-rate brachytherapy in uterine cervical carcinoma

    International Nuclear Information System (INIS)

    Purpose: High-dose-rate (HDR) brachytherapy is in wide use for curative treatment of cervical cancer. The American Brachytherapy Society has recommended that the individual fraction size be <7.5 Gy and the range of fractions should be four to eight; however, many fractionation schedules, varying from institution to institution, are in use. We use 9 Gy/fraction of HDR in two to five fractions in patients with carcinoma of the uterine cervix. We found that our results and toxicity were comparable to those reported in the literature and hereby present our experience with this fractionation schedule. Methods and Materials: A total of 121 patients with Stage I-III carcinoma of the uterine cervix were treated with HDR brachytherapy between 1996 and 2000. The total number of patients analyzed was 113. The median patient age was 53 years, and the histopathologic type was squamous cell carcinoma in 93% of patients. The patients were subdivided into Groups 1 and 2. In Group 1, 18 patients with Stage Ib-IIb disease, tumor size <4 cm, and preserved cervical anatomy underwent simultaneous external beam radiotherapy to the pelvis to a dose of 40 Gy in 20 fractions within 4 weeks with central shielding and HDR brachytherapy of 9 Gy/fraction, given weekly, and interdigitated with external beam radiotherapy. The 95 patients in Group 2, who had Stage IIb-IIIb disease underwent external beam radiotherapy to the pelvis to a dose of 46 Gy in 23 fractions within 4.5 weeks followed by two sactions within 4.5 weeks followed by two sessions of HDR intracavitary brachytherapy of 9 Gy each given 1 week apart. The follow-up range was 3-7 years (median, 36.4 months). Late toxicity was graded according to the Radiation Therapy Oncology Group criteria. Results: The 5-year actuarial local control and disease-free survival rate was 74.5% and 62.0%, respectively. The actuarial local control rate at 5 years was 100% for Stage I, 80% for Stage II, and 67.2% for Stage III patients. The 5-year actuarial disease-free survival rate was 88.8% for Stage I, 76.52% for Stage II, and 50.4% for Stage III patients. Local failure occurred in 2 (11.1%) of the 18 Group 1 patients and in 20 (21.0%) of the 95 Group 2 patients. Distant failure occurred in none of the Group 1 patients and in 8 (8.4%) of the 95 Group 2 patients. None of the patients developed Grade 3 rectal toxicity. Grade 3 bladder toxicity was observed in 2 patients. The actuarial risk of Grade 3 or worse late toxicity was 3.31%. Conclusion: The results of our study indicate that HDR brachytherapy at 9 Gy/fraction is both safe and effective in the management of carcinoma of the cervix, with good local control and a minimum of normal tissue toxicity

  10. Therapeutic Results of Postoperative Radiation Therapy for Uterine Cervical Cancer

    International Nuclear Information System (INIS)

    This is a retrospective analysis of 64 patients who was treated with postoperative radiation therapy after radical hysterectomy and bilateral pelvic lymphadenectomy (53 patients) or total abdominal hysterectomy(11 patients) for uterine cervix cancer between May 1980 and September 1991 at the Department of Radiation Oncology, Kyung Hee University Hospital. Most patients were FIGO IB (31 patients) and IIA (25 patients), and median period of follow-up was 5.1 years. Of these patients, 24 received adjuvant whole pelvis irradiation of 6000 cGy and 40 received 5000-5500 cGy whole pelvis irradiation and/or intracavitary radiation (7 patients). The actuarial overall and relapse free 5 year survival rate were 71.0%, 68.3% respectively. The survival rates by stage were 79.1% in stage I, and 61.2% in stage II. Treatment failure was noted in 18 of 64 patients (28.1%), locoregional failure in 8(12.5%), distant metastasis in 8(12.5%), paraaortic node metastasis in 1 and one patient had concurrent locoregional and distant metastasis. The univariate analysis of prognostic factors affecting to overall survival rate represented lymph node status, the number and site of metastatic lymph node, parametrial invasion, the thickness of cervical wall invasion, and size of cancer mass. Histology, vessel invasion, endometrial extension, hemoglobin level, resection margin status, age, radiation dose were not significant prognostic factors. Complication relating to operation and postoperative radelating to operation and postoperative radiation were variable according to radiation therapy method: 6000 cGy RT group 8/24(33.3%), 5000-5500 cGy+ICR 3/7(42.9%), 5000-5500 cGy external RT only group 3/33(9.1%). In conclusion, the results suggest that postoperative radiotherapy is necessary in high risk patients for locoregional control and improving survival rate, and higher dose not improve results but only increases complication

  11. Obstetric performance of a patient with multiple uterine and cervical fibroids and expectant management of retained placenta.

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    Begum, Mahfuza H.; Mustafa, Mohamed S.

    2002-01-01

    ABSTRACT The aim of this case report is to describe the obstetric performance of a patient with multiple uterine and supravaginal cervical fibroids. A 36-year-old, gravida 3 para 0+2 with multiple uterine and cervical fibroids presented with inevitable abortion at 17 weeks gestation. She had a spontaneous rupture of membranes followed by expulsion of fetus as breech with entrapment of aftercoming head by a cervical fibroid. Oxytocin infusion and digital traction were able to deliver the fe...

  12. Ex-vivo ultrasound attenuation coefficient for human cervical and uterine tissue from 5 – 10 MHz

    OpenAIRE

    Kiss, Miklos Z.; Varghese, Tomy; Kliewer, M. A.

    2010-01-01

    Attenuation estimation and imaging in the cervix has been utilized to evaluate the onset of cervical ripening during pregnancy. This feature has also been utilized for the acoustic characterization of leiomyomas and myometrial tissue. In this paper, we present direct narrowband substitution measurement values of the variation in the ultrasonic attenuation coefficient in ex vivo human uterine and cervical tissue, in the 5–10 MHz frequency range. At 5 MHz, the attenuation coefficient values a...

  13. Utility of the broccoli sign in the distinction of prolapsed uterine tumor from cervical tumor

    International Nuclear Information System (INIS)

    Objective: To describe the utility, histopathological basis, and clinical correlates of the broccoli sign. Methods: The committee on human research approved this HIPAA compliant study and waived written informed consent. Based on the records of the senior author and our multidisciplinary Gynecologic Oncology Tumor Board, we retrospectively identified thirteen women (mean age of 48.8 years; range, 34–74) with a cervical mass seen at MR imaging (n = 13) or CT (n = 5) that demonstrated the previously reported broccoli sign (i.e., a soft tissue stalk connecting the cervical mass to the uterine cavity) on one or other modality. All available clinical, imaging, and histopathological records were reviewed, with particular emphasis on initially suspected diagnosis, final proven diagnosis, and outcome. Results: Cervical cancer was the initial clinically suspected diagnosis in 6 of 13 patients. Surgical resection demonstrated prolapsed uterine tumor in all patients, consisting of endometrioid adenocarcinoma (n = 7), carcinosarcoma (n = 2), adenosarcoma (n = 1), and leiomyoma (n = 3). Excluding the three patients with leiomyomas, currently, 7 patients with malignant tumors are disease free after a mean interval of 15 months (range, 3–45) and 3 patients have been lost to follow-up. Conclusion: A stalk connecting an apparent cervical mass seen at CT or MR imaging to the endometrial cavity (“broccoli sign”) favors the diagnosis of a prolapsed uterine tumor; these prolapsed uterine tumors can often be malignant but appear to have a good prognosis.

  14. Primary cervical and uterine corpus lymphoma; a case report and literature review.

    Czech Academy of Sciences Publication Activity Database

    Anagnostopoulos, A.; Mouzakiti, N.; Ruthven, S.; Herod, J.; Kotsyfakis, Michalis

    2013-01-01

    Ro?. 6, ?. 4 (2013), s. 298-306. ISSN 1940-5901 R&D Projects: GA ?R GAP502/12/2409 Institutional support: RVO:60077344 Keywords : Non-Hodgkin's lymphoma * extra-nodal lymphoma * uterine/cervical lymphoma Subject RIV: EC - Immunology Impact factor: 1.422, year: 2013

  15. Value of intramuscular methotrexate and bilateral uterine artery embolization for treating cervical ectopic pregnancy

    International Nuclear Information System (INIS)

    Objective: To assess the clinical value of bilateral uterine artery chemotherapy embolization (UACE) for cervical ectopic pregnancy analyzed. Methods: Clinical records of 40 patients with cervical ectopic pregnancy treated using UACE were retrospectively analyzed. Results: 8 patients with severe active vaginal bleeding after curettage were treated urgently with UACE. The remaining 32 patients were treated with UACE combined with sequential ultrasound-guided curettage. Active vaginal bleeding was stopped after UACE. There was no recurrent hemorrhage with the sequential ultrasound-guided curettage procedure. The ?-HCG levels of all patients were normalized after 1 month. Conclusion: Bilateral uterine artery chemotherapy embolization is valuable as emergency treatment for patients with severe vaginal bleeding from cervical ectopic pregnancy. UACE combined with sequential ultrasound-guided curettage may be more effective. (authors)

  16. Uterine cervical cancer. Usefulness of MR imaging after the initial radiation therapy

    International Nuclear Information System (INIS)

    To evaluate the usefulness of magnetic resonance imaging (MRI) in diagnosing residual or recurrent tumors of cervical cancer after radiation therapy, we investigated the time difference between MRI and gynecologic findings in the diagnosis of residual or recurrent tumor in 12 patients with invasive cervical cancer. We defined a positive finding for residual or recurrent tumor as an uterine cervical mass isointense to muscle on T1-weighted images and hyperintense on T2-weighted images, and when a positive biopsy specimen was obtained. Two patients were diagnosed as having a residual or recurrent tumor by MRI. Positivity was demonstrated four and seven months later, respectively. MRI was more useful in the earlier diagnosis of residual or recurrent tumor of cervical cancer after radiation therapy than uterine biopsy. There was one patient whose differentiation from residual tumor or radiation-induced necrosis or inflammation on MRI was difficult. MRI and gynecologic check-up at a regular interval after radiation therapy was needed to distinguish them. One patient was diagnosed as having a recurrent tumor by gynecologic finding three months earlier than by MRI. Follow-up MRI examinations at a regular interval in addition to gynecologic examination is necessary for the early detection of recurrent cervical cancer after radiation therapy. (author)

  17. Expression of vascular endothelial growth factor (VEGF) and its mRNA in uterine cervical cancers

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    Fujimoto, J.; Sakaguchi, H.; Hirose, R.; Ichigo, S.; Tamaya, T.

    1999-01-01

    To know the potential of growth, invasion and metastasis of uterine cervical cancer associated with neovascularization, localization of vascular endothelial growth factor (VEGF) and microvessel density in tumours were determined by immunohistochemical staining, the levels of VEGF subtypes were determined by Western blot analysis and by a sandwich enzyme immunoassay, and the levels of VEGF subtype mRNAs were determined by reverse transcription polymerase chain reaction (RT-PCR) – Southern bl...

  18. Incidencia y mortalidad por cáncer cervicouterino / Incidence and mortality due to cervical uterine cancer

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    Yesika Isabel, Reyes Zuñiga; José Guillermo, Sanabria Negrín; Raydel, Marrero Fernández.

    2014-10-01

    Full Text Available Introducción: existe un desconocimiento del impacto del Programa de Detección Precoz del cáncer cervicouterino en el área de salud del policlínico Pedro Borrás Astorga. Objetivo: evaluar el impacto del Programa de Detección Precoz del Cáncer Cervicouterino en el área de salud del Policlínico Univers [...] itario "Pedro Borrás Astorga", Pinar del Río, 2004-2011. Material y método: se realizó una investigación observacional, descriptiva y retrospectiva, utilizando la base automatizada de datos de la Consulta Provincial de Patología de Cuello, del Registro Provincial de Cáncer y del Registro de Mortalidad de la provincia y el área de salud del Policlínico Universitario "Pedro Borrás Astorga" de Pinar del Río en el período considerado, y la Oficina Municipal de Estadísticas para año en particular. Se determinó la tasa de incidencia anual de lesiones en general, específicas por severidad y por grupos de edades, así como la frecuencia de muertes por esta causa. Resultados: el mayor número frecuencias de lesiones cervicales diagnosticadas fue detectado en el año 2010 (72 mujeres), la mayor frecuencia correspondió a neoplasias intraepiteliales cervicales grado I (de bajo grado) (203 NIC I). A medida que aumentaba el grado de severidad de las lesiones se observaba una disminución de las frecuencias y por tanto de las tasas de incidencias promedio anuales. La mortalidad por cáncer cervicouterino fue escasa. Conclusiones: incremento de las lesiones premalignas y de las tasas de incidencia anuales. Incremento de las lesiones premalignas en mujeres jóvenes (menores de 35 años) con respecto a las de 35 años y más. Incremento del carcinoma in situ en el tiempo. Tendencia decreciente de los casos de carcinomas invasores de cuello uterino y de la mortalidad por cáncer cervicouterino. Abstract in english Introduction: there is lack of knowledge about the impact of the Cervical Uterine Cancer Early Screening Program in the health area of Pedro Borrás Astorga University Outpatient Polyclinic. Objective: to evaluate the impact of the Cervical Uterine Cancer Early Screening Program in the health area of [...] Pedro Borrás Astorga University Outpatient Polyclinic, Pinar del Río, years 2004-2011. Material and method: an observation, retrospective and descriptive research was carried out, using the automatized database of the Provincial Medical Office of Cervical Pathology, from the Provincial Records of Cancer and the Province Mortality Records and the health area of Pedro Borrás Astorga University Outpatient Polyclinic in the considered period, and the Province Office of Statistics for a particular year. The annual incidence rate of lesions was determined, specifically by severity and age groups, and also the mortality rate for this cause. Results: the highest number of frequencies of cervical lesions diagnosed was detected in the year 2010 (72 women), the highest frequency corresponded to cervical intraepithelial neoplasias in stage I (low stage) (203 CIN I). The higher the lesions' degree of severity, the lower the frequencies, and thus the annual incidence rates. Mortality for cervical uterine cancer was acarce. Conclusions: increase in the number of premalignant lesions and the annual incidence rates. Increase in the number of premalignant lesions in young women (under 35 years of age) in comparison to those at age 35 or older. Increase in the number of in situ carcinoma within the time period. There was a decreasing tendency in the cases of invading cervical uterine carcinomata and the mortality for cervical uterine cancer.

  19. Liquid-based slice cervical cytology test in radiation treated cancer of the uterine cervix

    International Nuclear Information System (INIS)

    Objective: To observe the cervical cytological change after radiation therapy of cancer of uterine cervix and the clinical significance of Liquid-based cytology test (LCT). Methods: From 196 uterine cervical carcinoma patients, a total of 489 specimens of LCT were collected. All tests were performed one month after the conclusion of radiation treatment. Results: Detection rate of abnormal squamous epithelial cells was 40.3% (197/489), of which the findings of atypical squamous cells of undetermined significance (ASCUS), low grade squamous intraepithelial lesion (LSIL), high grade squamous intraepithelial lesion (HSIL) and squamous cell carcinoma(SCC) were observed in 20.1%, 5.3 %, 10.8% and 3.1% respectively. In benign reactive cervical cell detection, this article mainly describes the detection rate of inflammatory reactive cells which was 42.5%, of which the mild 6.34% inflammation took place, 19.4% moderate and 6.8% severe inflammation. All kinds of abnormal cell detection rates showed differences among each of the groups from 1 to 18 months of follow-up observation. Conclusions: Liquid-based cytology test may also be one of the predicting observation indexes if there is recrudescence locally in the future. (authors)

  20. Pelvic insufficiency fracture after definitive radiotherapy for uterine cervical cancer. Retrospective analysis of risk factors

    International Nuclear Information System (INIS)

    The purpose of this study is to determine the incidence, clinical characteristics and risk factors of postradiation pelvic insufficiency fracture (PIF) in women with uterine cervical cancer. We reviewed the medical records of 126 patients who received definitive radiotherapy (RT) for uterine cervical cancer between 2003 and 2009 at our institution. Among them, 99 patients who underwent at least one computed tomography (CT) or magnetic resonance imaging of the pelvis during their follow-up at more than 6 months were included in this analysis. The relationship between the incidence of PIF and several patient- and treatment-related factors was analyzed. The median follow-up period was 21 months. Of the 126 patients, 33 (with a total of 50 lesions) were diagnosed with PIF. The 2-year cumulative incidence was 32%. Univariate analysis showed that age ?70 years (P= 0.0010), postmenopausal state (P = 0.0013), and lower CT density of bone and bone marrow (P = 0.020) significantly related to PIF. In a multivariate analysis, of the 59 patients whose CT densities were evaluable, lower CT density was the only significant factor associated with PIF (P = 0.0026). In conclusion, postradiation PIFs were detected in a considerable number of patients after definitive RT for cervical cancer. Predisposing factors were older age, postmenopausal state, and decreased density of bone and bone marrow on CT. (author)

  1. Can MRI predict local control rate of uterine cervical cancer immediately after radiation therapy?

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate the utility of measuring the volumes of areas of high signal intensity on T2-weighted magnetic resonance (MR) images immediately after irradiation for predicting the local control rate of uterine cervical cancer. From our departmental database, we identified 109 patients with cervical cancer who underwent MR imaging before irradiation and just before or just after completion of radiation therapy from 1994 to 2007. We included 46 of the 109 patients in this study, 5 patients with local recurrence and 41 patients who were free of disease for more than 2 years. Fifteen received radiation therapy alone, and 28 patients received concurrent chemoradiation therapy. We measured the volumes of areas of high signal intensity involving the uterine cervix on T2-weighted MR images before radiation therapy and just before or just after its completion. We measured the 3 orthogonal diameters to calculate the volume as an ellipsoid and evaluated proportional tumor volume and the rate of reduction. We analyzed statistics with Student's t-test. In patients with local recurrence, the mean volume of the areas of high signal intensity on T2-weighted MR images just before completion of irradiation therapy or just after was 19.70 cm3, which was significantly larger than that in patients without recurrence (1.77 cm3, P2-weighted MR images include acute radiation change, their volume and the proportional tumor volume after irradiation can be useful clues in predicting the local control rate of uterine cervical cancer. (author)

  2. Usage of CT and tumor markers in the management of a patient with cervical cancer after colpocleisis for uterine prolapse

    International Nuclear Information System (INIS)

    A 79-year-old woman developed stage IIIb cervical carcinoma 13 years after colpocleisis for uterine prolapse. The patient was treated with external irradiation of 60 Gy and chemotherapy with 5-FU (100 mg/day) and Ok-432. The response of tumor could be monitored by serial changes in tumor markers, such as SCC, IAP, TPA, CEA, LDH, and ALP, and CT findings. Considering that colpocleisis makes it impossible to visualize the uterine cervix, the adequate selection of surgical procedure for uterine prolapse is required. (Namekawa, K.)

  3. A Hertzian contact mechanics based formulation to improve ultrasound elastography assessment of uterine cervical tissue stiffness.

    Science.gov (United States)

    Briggs, Brandi N; Stender, Michael E; Muljadi, Patrick M; Donnelly, Meghan A; Winn, Virginia D; Ferguson, Virginia L

    2015-06-25

    Clinical practice requires improved techniques to assess human cervical tissue properties, especially at the internal os, or orifice, of the uterine cervix. Ultrasound elastography (UE) holds promise for non-invasively monitoring cervical stiffness throughout pregnancy. However, this technique provides qualitative strain images that cannot be linked to a material property (e.g., Young's modulus) without knowledge of the contact pressure under a rounded transvaginal transducer probe and correction for the resulting non-uniform strain dissipation. One technique to standardize elastogram images incorporates a material of known properties and uses one-dimensional, uniaxial Hooke's law to calculate Young's modulus within the compressed material half-space. However, this method does not account for strain dissipation and the strains that evolve in three-dimensional space. We demonstrate that an analytical approach based on 3D Hertzian contact mechanics provides a reasonable first approximation to correct for UE strain dissipation underneath a round transvaginal transducer probe and thus improves UE-derived estimates of tissue modulus. We validate the proposed analytical solution and evaluate sources of error using a finite element model. As compared to 1D uniaxial Hooke's law, the Hertzian contact-based solution yields significantly improved Young's modulus predictions in three homogeneous gelatin tissue phantoms possessing different moduli. We also demonstrate the feasibility of using this technique to image human cervical tissue, where UE-derived moduli estimations for the uterine cervix anterior lip agreed well with published, experimentally obtained values. Overall, UE with an attached reference standard and a Hertzian contact-based correction holds promise for improving quantitative estimates of cervical tissue modulus. PMID:26003483

  4. The association of uterine cervical microbiota with an increased risk for cervical intraepithelial neoplasia in Korea.

    Science.gov (United States)

    Oh, H Y; Kim, B-S; Seo, S-S; Kong, J-S; Lee, J-K; Park, S-Y; Hong, K-M; Kim, H-K; Kim, M K

    2015-07-01

    Recent studies have suggested potential roles of the microbiome in cervicovaginal diseases. However, there has been no report on the cervical microbiome in cervical intraepithelial neoplasia (CIN). We aimed to identify the cervical microbiota of Korean women and assess the association between the cervical microbiota and CIN, and to determine the combined effect of the microbiota and human papillomavirus (HPV) on the risk of CIN. The cervical microbiota of 70 women with CIN and 50 control women was analysed using pyrosequencing based on the 16S rRNA gene. The associations between specific microbial patterns or abundance of specific microbiota and CIN risk were assessed using multivariate logistic regression, and the relative excess risk due to interaction (RERI) and the synergy index (S) were calculated. The phyla Firmicutes, Actinobacteria, Bacteroidetes, Proteobacteria, Tenericutes, Fusobacteria and TM7 were predominant in the microbiota and four distinct community types were observed in all women. A high score of the pattern characterized by predominance of Atopobium vaginae, Gardnerella vaginalis and Lactobacillus iners with a minority of Lactobacillus crispatus had a higher CIN risk (OR 5.80, 95% CI 1.73?19.4) and abundance of A. vaginae had a higher CIN risk (OR 6.63, 95% CI 1.61?27.2). The synergistic effect of a high score of this microbial pattern and oncogenic HPV was observed (OR 34.1, 95% CI 4.95?284.5; RERI/S, 15.9/1.93). A predominance of A. vaginae, G. vaginalis and L. iners with a concomitant paucity of L. crispatus in the cervical microbiota was associated with CIN risk, suggesting that bacterial dysbiosis and its combination with oncogenic HPV may be a risk factor for cervical neoplasia. PMID:25752224

  5. Nomogram Prediction of Overall Survival After Curative Irradiation for Uterine Cervical Cancer

    International Nuclear Information System (INIS)

    Purpose: The purpose of this study was to develop a nomogram capable of predicting the probability of 5-year survival after radical radiotherapy (RT) without chemotherapy for uterine cervical cancer. Methods and Materials: We retrospectively analyzed 549 patients that underwent radical RT for uterine cervical cancer between March 1994 and April 2002 at our institution. Multivariate analysis using Cox proportional hazards regression was performed and this Cox model was used as the basis for the devised nomogram. The model was internally validated for discrimination and calibration by bootstrap resampling. Results: By multivariate regression analysis, the model showed that age, hemoglobin level before RT, Federation Internationale de Gynecologie Obstetrique (FIGO) stage, maximal tumor diameter, lymph node status, and RT dose at Point A significantly predicted overall survival. The survival prediction model demonstrated good calibration and discrimination. The bootstrap-corrected concordance index was 0.67. The predictive ability of the nomogram proved to be superior to FIGO stage (p = 0.01). Conclusions: The devised nomogram offers a significantly better level of discrimination than the FIGO staging system. In particular, it improves predictions of survival probability and could be useful for counseling patients, choosing treatment modalities and schedules, and designing clinical trials. However, before this nomogram is used clinically, it should be externally validatednically, it should be externally validated.

  6. CT and ultra low field (0.02 T) MR imaging of uterine cervical carcinoma

    International Nuclear Information System (INIS)

    Nineteen pelvic MR and 21 CT examinations were performed in 21 patients with uterine cervical carcinoma. The results were compared with clinical (FIGO) staging in all patients, and with the histopathologic results after operation in 8. In the evaluation of local tumor growth CT agreed with clinical staging in 29%, MR imaging with clinical staging in 47% and CT with MR in 53%. The greatest discrepancy between the imaging methods and clinical examination was in the evaluation of parametrial extension. From 8 Stage I tumors with surgical confirmation the local tumor growth was overestimated with CT in 3 cases, with clinical examination in 2 and with MR imaging in 2 cases. CT and MR imaging at 0.02 T did not differ in the evaluation of parametrial tumor growth. Clinical examination overestimated parametrial growth but was relatively accurate in detecting vaginal wall involvement. MR imaging at 0.02 T is a convenient, inexpensive and accurate method for the local staging of early uterine cervical carcinoma. (orig.)

  7. Radiotherapy of Uterine Cervical Cancer Using Fletcher-Suit-Delclos Cesium Applicator

    International Nuclear Information System (INIS)

    From Nov. 1983 through Feb. 1986, 35 patients of uterine cervical cancer were treated by external radiation therapy and intracavitary radiation therapy using Fletcher-Sult-Delclos applicator. Age of the patients ranged from 32 to 70 years (median age:53 years). All patients had follow up from 9 to 34 months and median follow up of 20 months. 4 patients were in stage I, 25 were in stage II, 5 were in stage III and I was in stage IV. Overall regression rate was 80% and uncorrected actuarial 2 year survival rate was 88%. The incidence of rectal complications were analyzed. There was no rectal complication in the patients who received less than 7000 rad maximal rectal dose, but 2 out of 17 patients who received more than 7000rad developed moderate degree (grade 2) of rectal complication. In viewing of our results, Fletcher-Suit-Delclos applicator (3M) seemed to be an appropriate instrument for intracavitary radiation therapy in the patients of uterine cervical cancer

  8. Cytopathological and immunohistochemical study for estimating radiotherapeutic effects in uterine cervical cancer

    International Nuclear Information System (INIS)

    In order to estimate the effects of radiation on cancer tissue, cytopathological findings, BrdU labelling index (L.I), tumor markers and C-myc oncogene products were examined in 30 patients of uterine cervical cancer, before radiation, at around 10 Gy, 30 Gy, 50 Gy and at the end of the therapy. In order to assess the radiotherapeutic effects, the cytological, histological, immunohistological findings were evaluated by Papanicolaou's classification, Oboshi and Shimasato's grading system and BrdU L.I. In the cytology, the radiation effect, such as the enlargement and vacuolation of the nuclei and cytoplasm, was observed at around 10 Gy of radiation, and significantly increased at around 30 Gy showing lysis of the cells and pyknosis of the nuclei. The histological observation recorded remarkable change in the cancer tissue at around 30 Gy of radiation. The BrdU L.I. showed a meaningful decrease around 30 Gy in the radiosensitive cases compared with the radioresistant cases. Moreover, immunohistochemical investigation indicated the location of SCC and SLX in the cytoplasm of the cancer cells and of C-myo oncogene product at around 10 Gy. Ras oncogene was not found in the adenocarcinoma cases investigated. From these findings it is concluded that BrdU L.I., revealed by immunohistological study, is the most suitable indicator to estimate the response of radiation in cancer cells of the uterine cervix and that C-myc oncogene product has the potentiality to be used as a prog has the potentiality to be used as a prognostic factor in uterine cervical cancer treated by radiation therapy. (author)

  9. Uterine cervical cancer. Preoperative staging with magnetic resonance imaging; Zervixkarzinom. Praeoperatives Staging mittels Magnetresonanztomographie

    Energy Technology Data Exchange (ETDEWEB)

    Collettini, F.; Hamm, B. [Charite-Universitaetsmedizin Berlin, Campus Charite Mitte, Klinik fuer Radiologie, Berlin (Germany)

    2011-07-15

    The treatment of uterine cervical carcinoma is largely dependent on the tumor stage. Despite significant inaccuracies in the clinical examination, uterine cervical cancer remains the only gynecological form of cancer still largely staged according to clinical findings. Although imaging is still not included in the staging the recently published revised FIGO (Federation International de Gynecologie et d'Obstetrique) system encourages the use of modern cross-sectional imaging (magnetic resonance imaging MRI and computed tomography CT). Due to its high soft tissue contrast MRI allows excellent non-invasive assessment of the cervix with direct tumor delineation as well as assessment of the prognosis based on morphological factors. Studies in the literature report an accuracy of 93% for MRI in the preoperative assessment of tumor size and in the differentiation of operable from advanced cervical cancer. Therefore MRI is considered to be the optimal modality for diagnostic evaluation starting from FIGO stage IB1, for radiation therapy planning, and for exclusion of recurrence in follow-up. In this paper we give an overview of the role of magnetic resonance imaging in preoperative staging of uterine cervical cancer. (orig.) [German] Die Therapieplanung beim Zervixkarzinom ist weitgehend von der Stadieneinteilung nach FIGO (Federation International de Gynecologie et d'Obstetrique) abhaengig, die trotz erheblicher Ungenauigkeiten bei der klinischen Stadieneinteilung weiterhin aufgrund klinischer Untersuchungsbefunde erfolgt. Obwohl bildgebende Verfahren nach wie vor fuer die Stadieneinteilung nicht vorgesehen sind, wird im kuerzlich erschienen revidierten Stagingsystem der FIGO zum ersten Mal die Verwendung moderner Schnittbilddiagnostik (MRT und CT) befuerwortet. Die MRT ermoeglicht dank ihres hohen Weichteilkontrasts ein ausgezeichnetes nichtinvasives Staging des Zervixkarzinoms mit direkter Tumordarstellung sowie einer Prognoseabschaetzung anhand bildmorphologischer Faktoren. Nach Ergebnissen in der Literatur betraegt die Genauigkeit der MRT bei der praeoperativen Abschaetzung der Tumorgroesse sowie der Differenzierung operabler Zervixkarzinome von fortgeschrittenen Karzinomen 93%. Sie wird daher nicht nur als das Verfahren der Wahl zur diagnostischen Beurteilung ab FIGO-Stadium IB1 angesehen, sondern auch zur Strahlentherapieplanung sowie zum Rezidivausschluss im Rahmen der Nachsorge. In der folgenden Arbeit geben wir einen Ueberblick ueber die Rolle der MRT bei der praeoperativen Stadieneinteilung des Zervixkarzinoms. (orig.)

  10. Protein profiling underscores immunological functions of uterine cervical mucus plug in human pregnancy

    DEFF Research Database (Denmark)

    Lee, Deug-Chan; Hassan, Sonia S

    2011-01-01

    The cervical mucus plug (CMP) differs from the cervical secretions of non-pregnant women, and is the ultimate sealant of the uterine cavity during pregnancy. Although several studies have analyzed biochemical properties of large glycoproteins in the CMP, comprehensive information about its protein composition is yet unavailable. We hypothesized that protein profiling of the CMP could provide key clues to its physiological functions in pregnancy. For this purpose, five CMPs obtained from women in labor at term were analyzed by LC-MS/MS. Out of 291 total proteins identified, 137 were detected in two or more samples, which included S100A8, S100A9, and complement proteins (C3, C4a, C4b, C6, and C8g). Several proteins, which have not been described in the cervical mucus of non-pregnant women or in cervicovaginal fluids, such as CD81 antigen and pregnancy zone protein, were also identified. Gene ontology analysis of identified proteins showed significant enrichment of 28 biological processes such as 'activation of plasma proteins involved in acute inflammatory response' and 'positive regulation of cholesterol esterification'. We report the proteome of CMPs from pregnant women at term for the first time, and the overall findings strongly suggest an important role for the CMP in the maintenance of pregnancy and parturition.

  11. Clinical significations of G2-M stage partial synchronization on radiation therapies of uterine cervical carcinomas

    International Nuclear Information System (INIS)

    The present study revealed that irradiation-induced changes of repopulation and redistribution played an important role in radiosensitivity and cure process of human uterine cervical carcinoma. DNA measurements by a microspectrophotometer were made on Feulgen stained biopsy specimens obtained from 20 patients. On the other hand, flow-microfluorometric measurements with Fried's computed cell cycle analysis were made on transplanted human cervical carcinomas. The mean nuclear DNA amount of human cervical carcinoma cells increased according as the irradiation doses increase until 2,000 rad. Moreover, as regards with the mean nuclear diameter of cancer cells the same phenomenon was recognized, and there was an interrelation between the increase of mean nuclear DNA amount and that of mean nuclear diameter. This phenomenon was proved in nuclear DNA analysis by flow-microfluorometric measurements on transplanted human cervical carcinoma in nude mice. Computed cell cycle analysis of F.M.F. data demonstrated that this phenomenon was due to irradiation-induced changes of repopulation and redistribution. That is to say, irradiation induces the increase of cycling cells and then partial synchronization to G2-M stage. Examination of the interrelation between this phenomenon at 500 rad and 5 years survival rate demonstrated that there was more increase of nuclear DNA amount in the good prognosis group than in the poor prognosis group. Estimation of residual cells near the G1 stage ation of residual cells near the G1 stage at 2,000 rad demonstrated that there were more residual cells near the G1 stage in the poor prognosis group than in the good prognosis group. (author)

  12. Dynamic contrast-enhanced MRI in the diagnosis of uterine cervical cancer

    International Nuclear Information System (INIS)

    Objective: To investigate the imaging characteristics of dynamic contrast-enhanced MR imaging (DCE-MRI) in uterine cervical cancer(UCC), and to evaluate the efficacy of DCE-MRI in the diagnosis of UCC. Methods: A total of 39 cases of scratch-pathologically confirmed UCC patients with MRI data were analyzed (one case of carcinoma in sim being negative on MRI was excluded in this study). Time- intensity curves of ROI in pathological regions and adjacent normal regions were obtained and the enhanced rates at different times (16,32,48,64 and 300 s) were calculated. The ARSI% and MRSI% of various groups were compared with t test. Results: All the 39 lesions enhanced at 16 s in DCE, and there was maximum signal contrast between lesions and the surrounding normal tissue in the early arterial phase. ARSI% of tumor (1.97 ± 0.55)% was higher than normal tissue (1.22 ± 0.56 )%, and there was statistically significant difference between them (t=151.000, P3 cm group[(1.70 ± 0.25)% and (2.26 ± 0.18)%] were higher than ?3 cm group [(0.57 ± 0.16)% and (0.73 ± 0.04)%]. ARSI% and MRSI% were higher in the peri-uterine tissue infiltration group [(1.69 ± 0.21)% and (2.26 ± 0.11)%] than that of confined group [(0.63 ± 0.23)% and (0.83 ± 0.03)%] with statistically significant difference (P<0.05). The TIC of the 39 cases with UCC included type I in 25 cases(25/39), type II in 14 cases (14/39), and there was no type III cases. The TICs of the se III cases. The TICs of the surrounding normal tissue were of type III (26/39) and type II (11/39), and only 2 cases type I. Conclusions: The DCE-MRI can reflect the blood supply of the UCCs quantitatively. The early arterial phase in DCE-MRI can improve the detection rate of small lesions. The ARSI% and MRSI% may be helpful in some degree in prognostic assessment and staging of the uterine cervical cancer. (authors)

  13. [Assessment of the penetration of culture media in uterine cavity as an effect of cervical lavage before embryo transfer: prospective and observational study of samples obtained in hysterectomy].

    Science.gov (United States)

    Kably, A; Karchmer, S; Grosso, J M; Quesnel, C; Barroso, G

    2001-10-01

    Cervical lavage used to remove and cleaning some of the scale elements as well as cervical mucous during embryo transfer has been a regular practice in many reproductive centers worldwide. However, the microenvironment influence using these techniques will or not be detrimental in the embryo development. Under this issue, a prospective study was doing in 16 patients (underwent hysterectomy). A cervical lavage was performed previous to the procedure similar to the embryo's transfer step, subsequently cervical invasion was checking. The age was 36.4 +/- 8.6 years, preoperatory diagnosis was abnormal uterine bleeding (n = 4), myomata (n = 4), adenomiosis (n = 4), endometrial polyp (n = 3) and chronic pelvic pain (n = 1). Uterine weight was 127.5 +/- 55.4 g with a surgical time of 48.8 +/- 12.5 minutes. Medium in the uterine cavity was founded in only one case. We believe that cervical lavage is a secure technique in embryo transfer. PMID:11816524

  14. Changes in Bone Mineral Density in Uterine Cervical Cancer Patients After Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: To prospectively investigate the changes in bone mineral density (BMD) after pelvic radiation therapy in patients with uterine cervical cancer. Methods and Materials: Of 52 cervical cancer patients who received pelvic RT in our university hospital between 2009 and 2011, 46 patients without recurrence and who were followed up for more than 12 months were included in the study. The BMD of the irradiated region and nonirradiated regions, serum estradiol, tartrate-resistant acid phosphatase-5b, and N-terminal cross-linking telopeptide of collagen 1 were measured before, at 3 months after, and at 12 months after RT. The patient cohort was divided into 2 groups according to estradiol level before RT, and the groups were defined as postmenopausal (2 before RT and 0.746 and 0.841 g/cm2 12 months after RT, respectively. Significant decreases were observed in both groups (P2 before RT and were significantly decreased to 0.706 and 0.921 g/cm2 12 months after RT (P<.01 and P<.05, respectively). Estradiol significantly decreased 3 months after RT, whereas tartrate-resistant acid phosphatase-5b and N-terminal cross-linking telopeptide of collagen 1 continued to increase over time in the premenopausal group. Conclusions: A decrease in BMD in the irradiated region after RT was observed within 1 year, regardless of menopausal status. Furthermore, in premenopausal patients, pelvic RT caused a decrease in systemic BMD

  15. Distribution of Uterin Cervical Lesions and Relation Between Age and Parity Rates in the Mardin Province

    Directory of Open Access Journals (Sweden)

    Gülay AYDO?DU

    2013-01-01

    Full Text Available Objective: The aim of this study is to evaluate the incidence and distribution of cervical lesions and compare characteristics such as parity and age of the women in Mardin province.Material and Method: Pap smears were drawn from the women screened at Mardin Gynecology and Pediatric Diseases Hospital from 2008 to 2011. All cervicovaginal smears were conventional Pap smear samples evaluated according to the 2001 Bethesda system.Results: There were 3.332 patients in total, whose smears showed no lesions in 3.125 patients. The mean age and number of parities of those patients were 37.34±11.25 and 4.78±3.28. There were 207 smears showing any lesions in cervix; ASC-US, ASC-H, LSIL, HSIL, AGC, squamous cell carcinoma and endocervical adenocarcinoma in 151 (72.94%; 16 (7.72%; 20 (9.66%; 8 (3.86%; 10 (4.83%; 1 (0.48% and 1 (0.48% patient, respectively. The mean age and the parities of the patients were 37.63±10.77 years and 4,74±2,92. Although there was no difference between the control and lesion groups, the parity and the age of patients who had ?4 births in both the control and lesion groups were significantly higher than the patients with parities <4 births (p=0.000. There was no difference within the cervical lesion group comparing the ASC-US group with the total of the other lesions.Conclusion: High parity was one of the risk factor for having a lesion in uterine cervix in this population. This study represents an initial attempt to reflect the prevalence and the distribution of cervical lesions and their relation with the parity rates in the eastern regions in Turkey.

  16. Radiotherapy for uterine cervical cancer. Results of the 1995-1997 patterns of care process survey in Japan

    International Nuclear Information System (INIS)

    The aim of this study is to establish Japanese national practice patterns for uterine cervical cancer patients who received radiotherapy without surgery. The Japanese Patterns of Care Study (JPCS) conducted a national survey of 73 institutions using two-stage cluster sampling, and collected specific information on 591 patients with uterine cervical cancer treated by radiotherapy without planned surgery between 1995 and 1997. The median age of the patients was 70 years. Karnofsky performance status (KPS) was ?90 for 37%. Most patients (95%) had histology of squamous cell carcinoma. Ten percent were stage I, 29% stage II, 48% stage III and 13% stage IVA. Photon beams of 10-14 MV were the most used for external beam radiotherapy (EBRT). The beam energy utilized varied significantly by institution strata. Midline block was used in ?70% of institutions. Intracavitary brachytherapy (ICBT) was performed in 77%. Institution strata correlated significantly with the ICBT application. The majority of patients (89%) were treated with high-dose-rate (HDR) ICBT. The median single point A dose of HDR-ICBT was 600 cGy. The median summated point A dose from EBRT and HDR-ICBT was 5800 cGy (range: 1196-8600). The median overall treatment time including ICBT was 49 days. Twenty-four percent of the patients received chemotherapy. Concurrent chemoradiation was performed in 5%. The JPCS established the Japanese national practice patterns of care for uterine cervical cancer patients trea uterine cervical cancer patients treated with radiotherapy without planned surgery between 1995 and 1997. This survey demonstrated that the institutional strata significantly affected several practice patterns. (author)

  17. A thermosensitive gel formulation of an empirical traditional Chinese prescription for treating cervical erosion

    Directory of Open Access Journals (Sweden)

    Shuqing Zhou

    2012-10-01

    Full Text Available Cervical erosion, a pathological change associated with chronic cervicitis, is a common condition that is difficult to cure. Many patients particularly those with mild or medium infection and those preparing for pregnancy require a simple but effective medication. In this study, extracts of an empirical herbal prescription composed of six Chinese traditional drugs viz Cortex Phellodendri, Rhizoma Coptidis, Olibanum, Myrrha, borneol and catechu were formulated to facilitate intravaginal administration and improve efficacy. An extract of the first four components was formulated with borneol as a thermosensitive gel (TG while an extract of catechu used to prepare a regular gel (CG because of a chemical incompatibility. The optimized TG was prepared using poloxamer 407 and poloxamer 188. The CG was prepared using glycerin, carbopol and triethanolamine. The gels were characterized in vitro in terms of release of berberine (TG and total catechins (CG and in vivo in a rat model of cervical erosion. Treatment by once daily application of the TG for 7 days followed by once daily application of the CG for 3 days produced a restoration of normal tissues. Gel formulation of the empirical Chinese traditional remedy appears to provide a promising treatment for cervical erosion.

  18. Quality of life in conventional and conformal pelvic radiotherapy for cervical and uterine cancer

    International Nuclear Information System (INIS)

    Aim of the study. The development of modern radiotherapy techniques requires focusing attention on potential side effects and on the quality of life. The aim of the study was to assess radiation toxicity and quality of life in patients with cervical and endometrial cancer treated with conventional and conformal pelvic radiotherapy and to assess the impact of radiation toxicity on the latter. Material and methods. 50 patients treated with conventional and 50 patients treated with conformal pelvic radiotherapy in Clinical Department of Gynecological Radiotherapy in Lower Silesian Oncology Center between November 2004 and October 2005 entered a prospective study. We estimated the side- effects of radiotherapy according to EORTCI RTOG scales and quality of life according to the EORTC QLQ-C30 questionnaire. Results. There were no differences in physical, cognitive, emotional and role functions between the two study groups. Social functions were assessed as worse in the conformal radiotherapy group. Pain was more frequent in the conformal arm and nausea in the conventional arm. Global health and quality of life were better in the conformal arm. The performance status according to WHO affected global health and quality of life and physical functions. Late side-effects from the gastrointestinal system impaired physical, cognitive, emotional and social functions and global health and quality of life. Genitourinary late side- effects impaired physical functions and global qualipaired physical functions and global quality of life. Conclusions. We observed no important differences in the quality of life in patients with cervical and uterine cancer receiving conventional and conformal external beam pelvic radiotherapy. Performance status according to WHO and gastrointestinal and genitourinary late side-effects affect quality of life. (authors)

  19. Changes in Bone Mineral Density in Uterine Cervical Cancer Patients After Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Okonogi, Noriyuki; Saitoh, Jun-ichi; Suzuki, Yoshiyuki, E-mail: syoshi@gunma-u.ac.jp; Noda, Shin-ei; Ohno, Tatsuya; Oike, Takahiro; Ohkubo, Yu; Ando, Ken; Sato, Hiro; Nakano, Takashi

    2013-12-01

    Purpose: To prospectively investigate the changes in bone mineral density (BMD) after pelvic radiation therapy in patients with uterine cervical cancer. Methods and Materials: Of 52 cervical cancer patients who received pelvic RT in our university hospital between 2009 and 2011, 46 patients without recurrence and who were followed up for more than 12 months were included in the study. The BMD of the irradiated region and nonirradiated regions, serum estradiol, tartrate-resistant acid phosphatase-5b, and N-terminal cross-linking telopeptide of collagen 1 were measured before, at 3 months after, and at 12 months after RT. The patient cohort was divided into 2 groups according to estradiol level before RT, and the groups were defined as postmenopausal (<40 pg/mL) and premenopausal (?40 pg/mL). Results: The mean BMDs within the irradiation field (lumbar vertebra 5) in the postmenopausal and the premenopausal groups were 0.825 and 0.910 g/cm{sup 2} before RT and 0.746 and 0.841 g/cm{sup 2} 12 months after RT, respectively. Significant decreases were observed in both groups (P<.05 and P<.01, respectively). In addition, in the premenopausal group the mean BMDs of the nonirradiated regions at thoracic vertebrae 9-12 and lumbar vertebrae 2-4 were 0.753 and 0.958 g/cm{sup 2} before RT and were significantly decreased to 0.706 and 0.921 g/cm{sup 2} 12 months after RT (P<.01 and P<.05, respectively). Estradiol significantly decreased 3 months after RT, whereas tartrate-resistant acid phosphatase-5b and N-terminal cross-linking telopeptide of collagen 1 continued to increase over time in the premenopausal group. Conclusions: A decrease in BMD in the irradiated region after RT was observed within 1 year, regardless of menopausal status. Furthermore, in premenopausal patients, pelvic RT caused a decrease in systemic BMD.

  20. Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy

    International Nuclear Information System (INIS)

    Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of 69 Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

  1. The Prevalence and pattern of HPV-16 immunostaining in uterine cervical carcinomas in Ethiopian women: a pilot study

    Directory of Open Access Journals (Sweden)

    Mona M Rashed

    2011-03-01

    Full Text Available INTRODUCTION: Cancer of the cervix uteri is the second most common cancer among women worldwide. The association of human papillomavirus (HPV infection with cervical carcinogenesis is well documented. This is a pilot study aiming to studying the prevalence and the pattern of Human Papilloma Virus Type 16 (HPV16 by immunostaining in the tissues of cervical carcinomas of Ethiopian women. METHODS: 20 specimens of uterine cervical carcinomas were studied histopathologically and immunohistochemically for HPV16. RESULTS: Histologically the specimens were classified as: Ten cases were Non Keratinized Squamous cell carcinoma (NKSCC, six cases were Keratinized Squamous Cell Carcinoma (KSCC and four cases were Adenocarcinoma (ADC. Immunohistochemistry study showed positivity in eleven cases (55%; seven cases (35% were non-keratinized squamous cell carcinoma; three cases (15% were keratinized squamous cell carcinoma and one case (5% belonged to the adenocarcinomas. CONCLUSION: This study reveals a significant detection of HPV in Ethiopian women by the use of advanced techniques such as Immunohistochemistry (IHC. The data of this study suggested that the marked expression of the HPV 16 was in the less differentiated uterine cervix carcinomas

  2. Pre-invasive cervical disease and uterine cervical cancer in Brazilian adolescents: prevalence and related factors Doença cervical pré-invasiva e câncer cérvico-uterino em adolescentes brasileiras: prevalência e fatores associados

    OpenAIRE

    Denise Leite Maia Monteiro; Alexandre José Baptista Trajano; Kátia Silveira da Silva; Fábio Bastos Russomano

    2006-01-01

    The objective was to describe the prevalence and factors associated with uterine cervical cancer (CA) and high-grade squamous intraepithelial lesions (HSIL) in adolescents. A cross-sectional study was carried out with 702 sexually active adolescents treated at a general hospital in Rio de Janeiro, Brazil, from 1993 to 2002. Screening was performed by cytopathology and colposcopy and confirmation by biopsy. Exposure variables were socio-demographic characteristics and those related to reproduc...

  3. Therapeutic Results of Postoperative Radiation Therapy for Early Stage Uterine cervical Cancer

    International Nuclear Information System (INIS)

    This is a retrospective analysis of 67 patients with histologically proven invasive carcinoma of uterine cervix treated with surgery followed by adjuvant radiotherapy at Inje University Seoul Paik Hospital between october 1983 and september 1991. Postoperative radiotherapy was carried out in patients with high risks of locoregional recurrence such as positive pelvic lymph node (38 pts), large tumor size more than 3 cm (22 pts), cervical stromal invasion more than 2/3 (46 pts), parametrial involvement (9 pts), positive resection margin (147ts), endo/myometrial extension (10 pts), and angiolymphatic invasion (13 pts). Stage IA, IB, and IIA were 2(3%), 39(58.2%), and 26(38.8%), respectively. Median follow-up period was 48 months with ranges from 13 to 115 months. All 67 patients were treated externally with standard pelvic field with radiation dose ranging from 4080 to 6120 cGy in 4-6 weeks period of time. Of these, 45 patients received intracavitary radiotherapy. The overall survival rate and disease free survival rate at 5-year were 88.0% and 82.1%, respectively. The survival rates by stage were 87.l% in IB and 88.4% in IIA. Local control rate was 86.6%(58 pts). The treatment failure was noted in 12 of 67 Patients(17.9%): locoregional failure in 7(10.4%), distant metastasis in 3(4.5%), and locoregional and distant metastasis in 2 (3%). The univariate analysis of prognostic factors disclosed endo/myometrial extension as a significant factor of survival and recurrence (7icant factor of survival and recurrence (70.0% vs 91.l% P<0.05 and 30.0% vs 15.8%, respectively). The complication of postoperative radiotherapy was not significant and all patient were well tolerated. In conclusion, postoperative radiotherapy in patients with high risks of locoreginal recurrence is relatively well tolerated and it gives significantly improved survival rate especially in patients with positive lymph nodes, bulky tumor size( 3 cm), parametrial involvement, cervical stromal invasion more than 2/3, positive resection margin and angiolymphatic invasion

  4. Role of CD24 Protein in Predicting Metastatic Potential of Uterine Cervical Squamous Cell Carcinoma in Patients Treated With Radiotherapy

    International Nuclear Information System (INIS)

    Purpose: The protein CD24 is a cell surface protein that appears to function as an adhesion molecule; its expression has been shown to correlate with prognosis in a variety of tumors. The aim of this study was to evaluate the immunoreactivity of uterine cervical squamous cell carcinoma to CD24 and determine whether CD24 is associated with clinical and pathologic parameters, including prognosis. Methods and Materials: The expression of CD24 protein was immunohistochemically studied in 73 cases of uterine cervical squamous cell carcinoma. All patients were treated with definitive radiotherapy alone or with concurrent chemoradiotherapy. Two pathologists independently analyzed the immunostaining; they did not have knowledge of the patient outcomes and evaluated any changes according to the percentage of tumor cells stained as follows: negative, 5% reactive. Results: Positive staining was found in 43 cases (58.9%). The immunoreactivity did not correlate with age, International Federation of Gynecology and Obstetrics stage, lymph node metastasis, or tumor size. For patients who were CD24 negative, the total failure and distant metastasis rates were decreased about 20% compared with the rates for patients who were CD24 positive. On univariate analysis, the 5-year distant metastasis-free survival rate of CD24-negative patients was significantly greater than that of the CD24-positive patients (84.7% vs. 66.7%, respectively, p = 0.0497). The Interna7%, respectively, p = 0.0497). The International Federation of Gynecology and Obstetrics stage and CD24 expression were significantly associated with distant metastasis-free survival on multivariate analysis. Conclusions: CD24 expression was a significant independent prognostic factor for distant metastasis-free survival in patients with uterine cervical squamous cell carcinoma. In the future, prospective determination of CD24 expression might aid clinical practice in the selection of the appropriate therapy for individual patients

  5. Postoperative radiotherapy for uterine cervical cancer. Results of the 1995-1997 patterns of care process survey in Japan

    International Nuclear Information System (INIS)

    The objective of this study was to determine the average national practice of postoperative radiotherapy (RT) for uterine cervical cancer in Japan. The Japanese Patterns of Care Study (PCS) reviewed the process of care employed for 455 uterine cervical cancer patients who were treated with surgery followed by postoperative RT during 1995-1997. Cases with missing data were excluded from calculations of percentage and significance for each of the surveyed items. According to International Federation of Gynecology and Obstetrics (FIGO) stages, 198 patients (45%) were in stage I, 52 patients (12%) were in stage IIA, 146 patients (33%) were in stage IIB and 46 patients (10%) were in stage III/IVA. The most common surgical procedure among the patients was radical hysterectomy (73%). Three hundred and seventy patients (82%) were treated with external beam RT (ERT) alone, and 74 patients (17%) were treated with a combination of ERT and intracavitary RT (ICRT). A midline block was used for the pelvic field in 63 patients (14%). Only seven patients (2%) were treated with extended field ERT. Pelvic ERT was most often performed using anterior posterior-posterior anterior (AP-PA) opposed fields for 431 patients (97%). A majority of the patients (312 patients, 70%) were treated with a total dose of 45.0-50.4 Gy for ERT. Chemotherapy (CT) was administered to 178 patients (40%), neoadjuvant preoperative CT was administered to 80 patients (22%) and concurrent CT with postoperative RT ) and concurrent CT with postoperative RT was administered to 29 patients (8%). This PCS established the national practice average of postoperative RT for uterine cervical cancer. Follow-up studies need to be conducted to determine whether the observed differences in treatment processes affect outcomes. (author)

  6. Predictive role of post-treatment [18F]FDG PET/CT in patients with uterine cervical cancer

    International Nuclear Information System (INIS)

    Objective: To evaluate the efficacy of post-treatment positron emission tomography (PET)/computed tomography (CT) for identification of tumor recurrence, and to determine whether [18F]fluorodeoxyglucose (FDG) uptake measured as the maximum standardized uptake value (SUVmax) has predictive role regarding survival in patients with uterine cervical cancer. Methods: Medical records from 276 women with uterine cervical cancer who had post-treatment [18F]FDG PET/CT performed were retrospectively reviewed. Results of PET/CT scans were compared with histological or clinical examination. Results: Ninety-five (34.4%) of the 276 patients had documented recurrence by either surgical biopsy or clinical and imaging follow-up. Median duration from treatment to PET/CT scan was 24 months (range, 6–307). The overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of post-treatment PET/CT were 94.7%, 87.8%, 80.4%, 97%, and 90.2%, respectively. The PET/CT scan modified both the diagnostic or treatment plan in 67 patients (24.3%). Patients were divided into two groups according to cut-off SUVmax established on the basis of ROC analysis (<5.25 vs. ?5.25), and there was a significant difference in OS between groups (p = 0.001). In addition, the 5-year progression-free survival (PFS) and OS rates of patients with a negative PET/CT scan for recurrence were significantly better than those with a positive PET/CT (98.62% vs. 17.83%, p < 0.0001 for PFS, 99.31% vs. 85.38%, p = 0.0015 for OS). Conclusion: Post-treatment PET/CT scan is a sensitive and accurate surveillance modality, and provides prognostic information in uterine cervical cancer. Furthermore, it may allow individualization of patient care.

  7. Combined therapy of intra-arterial reservoir and radiotherapy on advanced uterine cervical cancer

    International Nuclear Information System (INIS)

    The efficacy of combined therapy of intra-arterial reservoir and radiotherapy was studied on 12 patients with advanced cervical uterine cancer. The patients were classified into two groups according to the agents used: Group A, intra-arterial administration of CDDP (10 mg/body/day) and 5-FU (250 mg/body/day) for 10 days; Group B, oral administration of Vp-16 (25 mg/body/day) for 7 days, followed by intra-arterial infusion of CDDP (100 mg/m2) for the first day and ADM (50 mg/m2) for the third day and intravenous infusion of CPM (200 mg/body/day) for 3 days. The size of tumor was reduced by several courses of chemotherapy preoperatively, then radiotherapy was performed. Whole-pelvis irradiation (40 Gy) was performed on 11 patients postoperatively, and internal irradiation (20 Gy) was performed preoperatively on 3 to control genital hemorrhage and postoperatively in 6. The reduced tumor size was evaluated by CT and MR. The efficacy rate was 75% (CR, 1; PR, 5; NC, 2)in the Group A and 50% (PR, 2; NC, 2) in the Group B, showing that intra-arterial infusion alone is enough to reduce the tumor size. Occlusion of the anterior raminus of left internal iliac artery was observed in one in the Group A. Transient leukopenia was observed in 2 in the Group A, which did not required any special treatment, and all patients in the Group B showed bone marrow suppression. The selection of irradiation field is still controversial, which needs to be further studied. (sial, which needs to be further studied. (S.Y.)

  8. An assessment of interfractional uterine and cervical motion: Implications for radiotherapy target volume definition in gynaecological cancer

    International Nuclear Information System (INIS)

    Purpose: To assess interfractional movement of the uterus and cervix in patients with gynaecological cancer to aid selection of the internal margin for radiotherapy target volumes. Methods and materials: Thirty-three patients with gynaecological cancer had an MRI scan performed on two consecutive days. The two sets of T2-weighted axial images were co-registered, and the uterus and cervix outlined on each scan. Points were identified on the anterior uterine body (Point U), posterior cervix (Point C) and upper vagina (Point V). The displacement of each point in the antero-posterior (AP), supero-inferior (SI) and lateral directions between the two scans was measured. The changes in point position and uterine body angle were correlated with bladder volume and rectal diameter. Results: The mean difference (±1SD) in Point U position was 7 mm (±9.0) in the AP direction, 7.1 mm (±6.8) SI and 0.8 mm (±1.3) laterally. Mean Point C displacement was 4.1 mm (±4.4) SI, 2.7 mm (±2.8) AP, 0.3 (±0.8) laterally, and Point V was 2.6 mm (±3.0) AP and 0.3 mm (±1.0) laterally. There was correlation for uterine SI movement in relation to bladder filling, and for cervical and vaginal AP movement in relation to rectal filling. Conclusion: Large movements of the uterus can occur, particularly in the superior-inferior and anterior-posterior directions, but cervical displacement is less marked. Rectal filling may affect cervical position, while bladder filling has more impact on uterineilling has more impact on uterine body position, highlighting the need for specific instructions on bladder and rectal filling for treatment. We propose an asymmetrical margin with CTV-PTV expansion of the uterus, cervix and upper vagina of 15 mm AP, 15 mm SI and 7 mm laterally and expansion of the nodal regions and parametria by 7 mm in all directions

  9. Analysis of High Dose Rate Intracavitary Radiotherapy (HDR-ICR) Treatment Planning for Uterine Cervical Cancer

    International Nuclear Information System (INIS)

    Purpose: This study was done to confirm the reference point variation according to variation in applicator configuration in each fractionation of HDR ICR. Materials and Methods: We analyzed the treatment planning of HDRICR for 33 uterine cervical cancer patients treated in department of therapeutic radiology from January 1992 to February 1992. Analysis was done with respect to three view points-Interfractionation A point variation, interfractionation bladder and rectum dose ratio validation, interfractionation treatment volume variation. Interfractionation A point variation was defined as difference between maximum and minimum distance from fixed rectal point to A point in each patient. Interfractionation bladder and rectum dose ration variation was defined as difference between maximum and minimum dose ratio of bladder or rectum to A point dose in each patient.. Interfractionation treatment volume variation was defined as difference between maximum and minimum treatment volume which absorbed over the described dose that is, 350 cGy or 400 cGy-in each patient. Results: The mean of distance from rectum to A point was 4.44cm , and the mean of interfractionation distance variation was 1.14cm in right side, 1.09cm in left side. The mean of bladder and rectum dose ratio was 63.8% and 63.1% and the mean of interfractionation variation was 14.9% and 15.8% respectively. With fixed planning administration of same planning to all fractionations as in first fractionation planninonations as in first fractionation planning mean of bladder and rectum dose ration was 64.9% and 72.3% and the mean of interfraction variation was 28.1% and 48.1% respectively. The mean of treatment volume was 84.15cm3 and the interfractionation variation was 21.47 cm3. Conclusion: From these data, it was confirmed that there should be adapted planning for every fractionation, and that confirmation device installed in ICR room would reduce the interfractionation variation due to more stable applicator configuration

  10. Uterine Cancer Statistics

    Science.gov (United States)

    ... Research AMIGAS Fighting Cervical Cancer Worldwide Stay Informed Statistics for Other Kinds of Cancer Breast Cervical Colorectal ( ... Skin Vaginal and Vulvar Cancer Home Uterine Cancer Statistics Language: English Español (Spanish) Recommend on Facebook Tweet ...

  11. High dose-rate brachytherapy for elderly patients with uterine cervical cancer

    International Nuclear Information System (INIS)

    The need for radiotherapy (RT) in cancer treatment for the elderly patient is growing. The purpose of this study was to analyze the efficacy and complication rate for radiotherapy, using external-beam irradiation (EBRT) and high dose-rate intracavitary brachytherapy (HDRICB), for patients aged 70 years or older with carcinoma of the uterine cervix. From September 1992 to December 1997, 295 patients diagnosed with uterine cervical cancer completed RT at the Shin Kong Memorial Hospital and China Medical College Hospital. Two hundred and fifty-eight patients [International Federation of Gynecology and Obstetrics (FIGO) stage distribution: 35 Ib, 26 IIa, 122 IIb, 10 IIIa, 58 IIIb, 7 IVa] who had undergone at least two courses of HDRICB and a minimum of 3 years of follow-up, were evaluated. A retrospective analysis was conducted to compare the outcome of radiation therapy for the 179 patients under 70 years of age (younger group) and the 79 patients aged 70 years or older (older group). The RT consisted of EBRT followed by HDRICB. After a total EBRT dose of 40-45 Gy/20 in 25 fractions, irradiating the whole pelvis over 4-5 weeks, dosage for patients diagnosed as FIGO stage IIb-IVa bilateral parametrial disease was boosted to 54-58 Gy, with central shielding. HDRICB was administered at 1-week intervals using an Ir-192 remote after-loading technique. Ninety-nine patients (38.4%) received three fractions of HDRICB, while 156 patients (60.5%) had four fractions. Total prescrib(60.5%) had four fractions. Total prescribed Point A dosages (EBRT+HDRICB) ranged from 58 to 71.6 Gy (median, 65.6 Gy) for stage IB-IIA, while for larger lesions (stage IIB-IVA) analogous dosages were 59-75.6 Gy (median, 65.6 Gy). Median follow-up durations for the older and younger groups were 56/55 months, respectively. The respective 5-year actuarial survivals (AS) for the older and younger groups were 82/85% for stage Ib, 65/65% for IIa, 61/71% for IIb and 35/59% for IIIa-b. The 5-year cause-specific survivals (CSS) for the older and younger groups were 100/95% for stage Ib, 85/75% for IIa, 78/72% for IIb and 42/61% for IIIa-b. The 5-year pelvic relapse-free survivals (PRFS) for the older and younger groups were 100/100% for stage Ib, 91/93% for IIa, 91/90% for IIb and 67/80% for IIIa-b. The 5-year distant metastasis-free survivals (DMFS) for older and younger groups were 100/100% for stage Ib, 92/88% for IIa, 84/73% for IIb and 55/75% for IIIa-b. There was no statistically significant survival difference on comparing the two groups according to stage. The gross tumor-free ratios after EBRT (NRT) for the older and younger groups were 44.3/24.5% (P=0.001). The 5-year CSS for the 35 NRT patients was 88% for the older group, while for the 44 patients diagnosed with gross residual tumor after EBRT (GRT) it was 64% (P=0.001). Twelve (15.0%) of the 79 older patients and 14 (7.8%) of the 179 younger patients developed Radiation Therapy Oncology Group (RTOG) grade 3-4 rectal complications (P=0.12), while seven (8.9%) of the 79 older patients and 10 (5.6%) of the 179 younger patients developed RTOG grade 3-4 small bowel complications (P=0.34). Radiation therapy, consisting of a combination of EBRT and three or four fractions of HDRICB, proved to be effective for older patients. Further optimization of treatment policy is essential by changing the HDRICB fractionation strategy, shortening the treatment time and designing combination drug regimens that are both effective and tolerable during radiotherapy. (author)

  12. Expression of Bmi-1, P16, and CD44v6 in Uterine Cervical Carcinoma and Its Clinical Significance

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    Mei-ying Weng

    2012-03-01

    Full Text Available Objective: Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The p16 protein negatively regulated cell proliferation, whereas CD44v6 is associated with proliferation as an important protein. Additionally, CD44v6 is an important nuclear antigen closely correlated to tumor metastasis. The present study aims to investigate the expression and significance of Bmi-1, p16, and CD44v6 in uterine cervical carcinoma (UCC. Methods: A total of 62 UCC, 30 cervical neoplasic, and 20 normal cervical mucosal tissues were used in the current study. The expression of Bmi-1, p16, and CD44v6 in these tissues was determined using immunohistochemical assay. The relationships among the expression of these indices, the clinicopathologic features of UCC, and the survival rate of UCC patients were also discussed. The correlation between Bmi-1 protein expression and p16 or CD44v6 protein in UCC was analyzed. Results: The expression of Bmi-1, p16, and CD44v6 was significantly high in cervical carcinoma compared with that in the cervical neoplasia and normal colorectal mucosa (P0.05. The Kaplan–Meier survival analysis showed that the over-expression of Bmi-1 significantly decreased the survival rate of UCC patients (P<0.05. A strong correlation indicated that there was statistical significance between the expression of Bmi-1 and CD44V6 proteins in UCC (r=0.419, P=0.001. Conclusions: The over-expression of Bmi-1 and CD44v6 protein closely correlate to the tumorigenesis, metastasis, and prognosis of UCC. Bmi-1 and CD44v6 may be used to predict the prognosis of cervical carcinoma. Bmi-1 may indirectly regulate the expression of CD44v6 in UCC patients. The positive expression of p16 protein is possibly associated with the tumorigenesis, but not with the metastasis or prognosis of UCC.

  13. Effects of radiotherapy combined with daily intramuscular injection of bleomycin for uterine cervical cancer

    International Nuclear Information System (INIS)

    A total of 103 cases of cancer of the uterine cervix, untreated previously, were treated with radiotherapy combined with daily intramuscular injection of Bleomycin 30 minutes before irradiation (BR therapy) in 12 institutions. Result showed that especially in cases of stage III, BR therapy was superior in primary local control rate (89.6%), recurrence rate (20.8%) and crude 5-year survival rate (56.5%) to that of nationwide statistics. No severe side effects were found. It was concluded that external radiotherapy could control advanced cancers of uterine cervix combining with intramuscular injection of Bleomycin. (author)

  14. Local lymphocytes and nitric oxide synthase in the uterine cervical stroma of patients with grade III cervical intraepithelial neoplasia

    Scientific Electronic Library Online (English)

    Cléber Sergio da, Silva; Marcia Antoniazi, Michelin; Renata Margarida, Etchebehere; Sheila Jorge, Adad; Eddie Fernando Candido, Murta.

    Full Text Available OBJECTIVES: Precancerous and cancerous cells can trigger an immune response that may limit tumor development and can be used as a prognostic marker. The aims of the present study were to quantify the presence of B and T lymphocytes, macrophages and cells expressing inducible nitric oxide synthase (i [...] NOS) in the cervical stroma of women with grade III cervical intraepithelial neoplasia (CIN III) or in the intratumoral and peritumoral tissue of women with stage I invasive carcinoma. METHODS: Cervical tissue specimens were obtained from 60 women (20 each from control tissues, CIN III and invasive carcinomas). The average ages in the control, CIN III and invasive groups were 43.9 (± 4.3), 35.5 (± 9.5), and 50 (± 11.2) years, respectively. The specimens were immunohistochemically labeled with antibodies to identify T lymphocytes (CD3), cytotoxic lymphocytes (CD8), B lymphocytes (CD20), macrophages (CD68) and iNOS. We evaluated the markers in the stroma above the squamocolumnar junction (control), at the intraepithelial lesion (CIN cases), and in the nfiltrating tumor. Two independent observers performed the immunohistochemical analysis. RESULTS: T lymphocytes, B lymphocytes, macrophages and iNOS were present more frequently (P

  15. A study of high-dose-rate intracavitary brachytherapy boost for curative treatment of uterine cervical cancer

    Science.gov (United States)

    Yamashita, Hideomi; Kobayashi, Reiko; Nakagawa, Keiichi

    2015-01-01

    Purpose This study assessed the trial of boost intracavitary brachytherapy (ICBT) for the patients of uterine cervical cancer with residual malignant cells detected at the final stage of ICBT. Material and methods This is a retrospective analysis of 75 patients with cervical cancer treated radically with external beam radiotherapy and high-dose-rate intracavitary brachytherapy between August 2004 and December 2008. Eighteen patients (24%) out of 75 received one additional ICBT and five patients (7%) had two additional ICBT. All 75 patients were retrospectively analyzed. The median follow-up time was 30 months. The median age was 59 years (range 28-85 years). There were 12 patients (16%) in stage IB, 27 (36%) stage II, 22 (29%) stage III, and 14 (19%) stage IV. Results The 5-year overall survival rate was 65%. Non-hematological toxicities greater than grade 2 occurred in 12 patients (16%). Of these, only two patients received on additional ICBT. No significant difference was found in grade 3 toxicity between patients who did and did not receive additional ICBT (p = 0.8). Conclusions The method to perform dose escalation should be examined depending on the treatment response.

  16. Metastatic cervical lymphadenopathy from uterine leiomyosarcoma with good local response to radiotherapy and chemotherapy

    International Nuclear Information System (INIS)

    The metastasis of uterine leiomyosarcoma to the neck node has not been reported previously and the radiotherapy has been rarely used for the metastatic lesion of the other sites. We report a case of neck metastasis from a uterine leiomyosarcoma, which developed 10 months after surgery and postoperative pelvic radiotherapy. It also involved the parapharyngeal space, adjacent spine, and spinal canal. The metastatic neck mass was inoperable, and was treated by neck radiotherapy (6,000 cGy) and chemotherapy including taxol and carboplatin. The mass has regressed progressively to a nearly impalpable state. She has never developed spinal cord compression syndrome, and has maintained good swallowing for eight months since the neck radiotherapy and chemotherapy. Since the extensive metastatic neck mass showed good local response to high dose radiotherapy and chemotherapy, both treatments may be considered for an unresectable metastatic leiomyosarcoma

  17. Computed tomographic findings in pelvic cavity after radiation therapy for uterine cervical carcinoma

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    Park, Jun Sang; Jeon, Woo Ki; Han, Chang Yul; Lee, Kwan Seh [School of Medicine, Inje University, Paik Hospital, Seoul (Korea, Republic of)

    1989-10-15

    The effect of pelvic irradiation may be seen mainly in the perirectal area related with the irradiating field. It is important to differentiate the postirradiation change from the recurrency or residual tumor of cervical cancer in the clinical prognostic view of the patient. The prominent postirradiation changes may be difficult to differentiate from the recurrency or residual tumor of cervical cancer. The authors analysed the computed tomographic findings of 35 patients who had received radiation therapy of cervical cancer at Inje University Seoul Paik Hospital. The radiation changes were compared with pre, and postirradiative CT findings in sequential follow-up course. The result were as follows: 1. Significant changes could be observed at least 3 months after irradiation. 2. Postirradiation changes included: Symmetrical thickening of perirectal fascia 28 cases 77%. Increased perirectal fat 26 cases 75%. Fibrous connection between sacrum and rectum 20 cases 57%. Widening of presacral space 14 cases 42%. Irregular thickening of rectal wall 5 cases 14%.

  18. Computed tomographic findings in pelvic cavity after radiation therapy for uterine cervical carcinoma

    International Nuclear Information System (INIS)

    The effect of pelvic irradiation may be seen mainly in the perirectal area related with the irradiating field. It is important to differentiate the postirradiation change from the recurrency or residual tumor of cervical cancer in the clinical prognostic view of the patient. The prominent postirradiation changes may be difficult to differentiate from the recurrency or residual tumor of cervical cancer. The authors analysed the computed tomographic findings of 35 patients who had received radiation therapy of cervical cancer at Inje University Seoul Paik Hospital. The radiation changes were compared with pre, and postirradiative CT findings in sequential follow-up course. The result were as follows: 1. Significant changes could be observed at least 3 months after irradiation. 2. Postirradiation changes included: Symmetrical thickening of perirectal fascia 28 cases 77%. Increased perirectal fat 26 cases 75%. Fibrous connection between sacrum and rectum 20 cases 57%. Widening of presacral space 14 cases 42%. Irregular thickening of rectal wall 5 cases 14%

  19. Apparent rarity of asymptomatic herpes cervicitis in a woman with intra-uterine contraceptive device

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    Adeola Fowotade

    2013-12-01

    Full Text Available Infection with genital herpes simplex virus (HSV remains a common viral sexually transmitted disease, often subclinical and a major worldwide problem of women of reproductive age group. Herpes cervicitis is an unusual presentation of Herpes simplex virus infection in females. The finding of herpes cervicitis on routine pap smear of an asymptomatic woman on Intrauterine contraceptive device still further supports the need for increased awareness on the possibility of Herpes simplex virus infection among women, particularly those on Intrauterine contraceptive device. The index case is a 28 years old Nigerian female who was referred to our Special Treatment Clinic on account of an abnormal pap smear cytology which was in keeping with Herpes cervicitis. There was no history of genital ulcer in this patient; however ELISA for HSV 2 IgM was positive in her. We therefore describe a case of herpes cervicitis in an asymptomatic woman on intrauterine contraceptive device. This case highlights to clinicians the need to be aware of the possibility of this association and to carry out relevant investigations so as to identify and treat these patients appropriately. Therefore, there is a need to put in place adequate public health intervention strategy to prevent genital herpes in women of reproductive age group with a view to preventing the possibility of congenital herpes in subsequent pregnancy.

  20. El cáncer cervicouterino y las lesiones precursoras: revisión bibliográfica / Cervical-uterine cancer and precursor lesions: a literature review

    Scientific Electronic Library Online (English)

    José Guillermo, Sanabria Negrín; Zoila C, Fernández Montequín; Inalvis de la Caridad, Cruz Hernández; Leonardo Oriolo, Pérez; Margarita, Llanuch Lara.

    2011-12-01

    Full Text Available Con el objetivo de actualizar el estado del arte sobre el cáncer cervicouterino y las lesiones precursoras se realizó una revisión bibliográfica de los artículos publicados en los últimos 5 años, y de otros originales teniendo en cuenta su nivel de evidencia médica I - II. Se utilizaron los buscador [...] es de la biblioteca Cochrane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, J Clinical Oncology, Medscape, PubMed, PubMed Central y artículos de la Agencia Internacional del Cáncer de Francia. Se revisaron los siguientes aspectos: Definiciones, epidemiología, etiología, factores de riesgo, citología, colposcopia, histopatología, clasificaciones, estadios clínicos, tratamientos, prevención, promoción de salud y problemas sociales. El cáncer cervicouterino es una enfermedad prevenible y curable, multifactorial, trasmitida sexualmente por el Virus del Papiloma Humano, con alta incidencia y prevalencia, y a pesar de los programas de pesquisaje continúa siendo un problema de salud. Se necesita de monitoreo permanente del programa de detección precoz en todos los ámbitos y alternativas de pesquisaje, adecuadas localmente a las necesidades, y de fuertes prevención y tratamiento para poder disminuir la carga social y económica que de este problema se derivan. Abstract in english Aimed at knowing the state of the art of cervical-uterine cancer and precursor lesions a literature review was carried out supported on the articles published in the last five years and from other original sources considering the levels I-II of medical evidences. Health information sources from Coch [...] rane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, Journal of Clinical Oncology, Medscape, PubMed, Central PubMed and French International Cancer Agency were used to revise the following aspects: definitions, epidemiology, etiology, risk factors, cytology, colposcopy, histopathology, classifications, clinical stages, treatments, prevention, health promotion and social problems. Cervical-uterine is a preventable, curable and multifactorial disease that is sexually transmitted by Human Papilloma Virus, presenting a high incidence and prevalence. Despite continuing screening programs, it is a health problem. Permanent monitoring programs to the early detection of this entity from all scopes must be carried out, along with screening alternatives that should be adjusted to the local needs, as well as the design of prevention and treatment programs to reduce social and economic burden resulting from this health problem.

  1. Clinical study on protective of glutathione from radiation injuries in uterine cervical cancer

    International Nuclear Information System (INIS)

    The protective effects of glutathione (GSH) against radiation were studied by the single, blind method in patients with carcinoma of the uterine cervix treated by radiotherapy. The background factors were same in the GSH group as in the control group. The results revealed that the occurrence of abnormal values of WBC, PLT, GOT, GPT and hematocrit in the GSH group were significantly lower than those in the control group by signed rank test, which suggests a possibility that GSH prevents these blood findings from becoming abnormal. In subjective or objective symptoms, the appearance of general lassitude was significantly reduced in the GSH group. Blood findings were studied in relation to NSD. (auth.)

  2. A fusion-based approach for uterine cervical cancer histology image classification

    OpenAIRE

    De, Soumya; Stanley, R. Joe; Cheng LU; Long, Rodney; Antani, Sameer; Thoma, George; Zuna, Rosemary

    2013-01-01

    Expert pathologists commonly perform visual interpretation of histology slides for cervix tissue abnormality diagnosis. We investigated an automated, localized, fusion-based approach for cervix histology image analysis for squamous epithelium classification into Normal, CIN1, CIN2, and CIN3 grades of cervical intraepithelial neoplasia (CIN). The epithelium image analysis approach includes medial axis determination, vertical segment partitioning as medial axis orthogonal cuts, individual verti...

  3. Central cervical fibroid mimicking as chronic uterine inversion: a case report

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    Swati Singh

    2013-08-01

    Full Text Available Leiomyomas are most common benign gynaecological tumor. Most of the fibroids are situated in the body of the uterus, but only in 1-2% cases, they are confined to cervix. We report a case of 33 years old women, para 2 live 2 diagnosed as myomatous polyp on ultrasound and clinically as chronic inversion of uterus. On surgery, we found it as central cervical fibroid with uterus sitting on the fibroid i.e. lantern on the St. Paul?s. [Int J Reprod Contracept Obstet Gynecol 2013; 2(4.000: 687-688

  4. A case report with typical acute radiation cystitis by postoperative external irradiation to uterine cervical cancer

    International Nuclear Information System (INIS)

    A patient with stage IIb cervical cancer who was treated with radical operation and postoperative external irradiation suffered from typical severe acute radiation cystitis at the radiation dose of 4200 rads. This complication is rare at present. Even though this complication is rare but cannot be completely ruled out, periodic urinalysis is necessary during radiation therapy. It is important to diagnose this complication and stop the radiotherapy as soon as possible. As adrenal cortical hormone is thought to be effective, the administration of it should be recommended. (Kumagai, M.)

  5. Uterine Sarcoidosis: A Rare Extrapulmonary Site of Sarcoidosis

    OpenAIRE

    Marak, Creticus P.; Narendrakumar Alappan; Amit Chopra; Olena Dorokhova; Sumita Sinha; Guddati, Achuta K

    2013-01-01

    Sarcoidosis is a multisystem disease which is most commonly manifested in the pulmonary system. However, extrapulmonary manifestations have also been frequently reported. Isolated occurrence of sarcoidosis in the genital system is rare and poses a diagnostic and therapeutic dilemma. Uterine sarcoidosis can present with cervical erosions, endometrial polypoid lesions, and recurrent serometra. In majority of cases, it is diagnosed by endometrial curettage, but it has also been detected by exami...

  6. Cytotoxic effect and radiation enhancement of artemisinin in uterine cervical carcinoma cell line HeLa

    International Nuclear Information System (INIS)

    Objective: To investigate cytotoxic and radiosensitizing effect of Artemisinin on cervical carcinoma cell line HeLa. Methods: In order to measure the optimized effective time, cytotoxic effect of Artemisinin on HeLa cell line was investigated with MTT assay. The radiosensitization effect of different doses and different treatment duration of Artemisinin on HeLa cell line were evaluated by MTT test, the SER is 1.17 and radiosensitizing effect was measured with multi-target single hit model through SER of HeLa cell. Cell cycles in different groups were calculated by flow cytometry. Results: The 50% inhibition concentration of Artemisinin interacted with HeLa cells for 24 h is 600.19 nmol/ml, and for 48 h is 160.71 nmol/ml. The HeLa cells'surival ratio is 93.51%, 91.87%, and 87.28% after adding Atemisinin of 110.69 nmol/ml and 1 Gy radiation exposure. There are three groups: the chemotherapy only group, the radiotherapy only group and the combination group. The result of the cell cycles showed that cells in G2/M period decreased in the combination group. Conclusion: Artemisinin has radiosensitization effect on cervical carcinoma HeLa cells, whichshows dose and time dependent. Artemisinin can inhibit the G2/M block by ionizing radiation. (authors)

  7. Pre-invasive cervical disease and uterine cervical cancer in Brazilian adolescents: prevalence and related factors Doença cervical pré-invasiva e câncer cérvico-uterino em adolescentes brasileiras: prevalência e fatores associados

    Directory of Open Access Journals (Sweden)

    Denise Leite Maia Monteiro

    2006-12-01

    Full Text Available The objective was to describe the prevalence and factors associated with uterine cervical cancer (CA and high-grade squamous intraepithelial lesions (HSIL in adolescents. A cross-sectional study was carried out with 702 sexually active adolescents treated at a general hospital in Rio de Janeiro, Brazil, from 1993 to 2002. Screening was performed by cytopathology and colposcopy and confirmation by biopsy. Exposure variables were socio-demographic characteristics and those related to reproductive health, habits, and sexual behavior. Adjusted odds ratios were estimated using multivariate logistic regression analysis. Based on histopathology, the prevalence of HSIL/CA was 3% (95%CI: 1.8-4.6. There was one case of invasive cancer. With each additional pregnancy, the odds of HSIL/CA increased by 2.2 (95%CI: 1.1-4.4. Age was also associated with this outcome, doubling the odds of acquiring this degree of disease with each year of age (OR = 2.0; 95%CI: 1.2-3.4. The prevalence of lesions suggests the importance of including sexually active adolescent females in cervical cancer screening programs aimed at early detection and treatment of these lesions.O objetivo foi descrever a freqüência e os fatores associados ao câncer cervical (CA e lesões escamosas intra-epiteliais de alto grau (HSIL entre adolescentes. Realizou-se estudo transversal com 702 adolescentes sexualmente ativas, assistidas em um hospital geral no Rio de Janeiro, Brasil, entre 1993 e 2002. A investigação foi realizada através de citopatologia e colposcopia, e a confirmação por biópsia cervical. As variáveis de exposição foram características sociais e demográficas, e aquelas relacionadas à saúde reprodutiva, hábitos e comportamento sexual. Baseado nos achados histopatológicos, a freqüência de HSIL/CA foi 3% (IC95%: 1,8-4,6. Houve um caso de câncer invasivo. A cada nova gestação, a chance de HSIL/CA aumentava 2,2 vezes (IC95%: 1,1-4,4. A idade também esteve associada com este resultado (OR = 2,0; IC95%: 1,2-3,4, dobrando a cada ano de idade a chance de adquirir este nível da doença. A freqüência de lesões cervicais intra-epiteliais sugere a importância de incluir adolescentes sexualmente ativas nos programas de prevenção do câncer cervical, com o objetivo de detectar e assegurar o tratamento precoce destas lesões.

  8. Knowledge, attitudes and practices on cervical cytology-uterine in women from sincelejo and Cartagena, colombia

    Directory of Open Access Journals (Sweden)

    Barrrios-Garcia Lia

    2011-12-01

    Full Text Available Although in Colombia screening programs of cervical cancer have achieved high levelsof coverage, cervical cancer has the first places in incidence and mortality. There isthe need to identify factors influencing it, among them is to investigate the level ofawareness of women about the screening test, their attitudes to screening and itspractices. For this we made a survey of 505 women 13 to 60 years who have had sexual life, living in the cities of Cartagena and Sincelejo (Colombia.The results showthat virtually all women have knowledge of cervical cytology, 94.5% of women havemade at least once. This percentage is higher in the range of 40 to 60 years where itreaches 99% in younger women this percentage decrease. In defining its usefulness,only 73.8% responded accurately. 50% reported unpleasant aspects related to themaking of the cytology, such as fear, and fear of a cancer diagnosis. A fail to rememberis the main factor for not claiming the results.These data show that the percentage ofwomen with sexual life that ignores the usefulness of cytology or never have practicedis minimal, which leads to the conclusion that ineffective screening programs to reducecervical cancer rates depends on other factors that should be investigated.RESUMEN:Aunque en Colombia los programas de prevención del cáncer de cérvix han alcanzadoaltos niveles de cobertura, todavía este ocupa los primeros lugares en incidencia ymortalidad. Existe la necesidad de identificar los factores que influyen en ello, por tantoes importante investigar el nivel de conocimiento de las mujeres sobre la prueba detamizaje, su actitud frente a la misma y sus prácticas relacionadas. Se realizó encuestaa 505 mujeres entre 13 y 60 años edad, que habían tenido vida sexual, residentes en lasciudades de Cartagena y Sincelejo (Colombia. Los resultados revelan que prácticamentetodas las mujeres tienen conocimientos sobre citología cérvico-uterina. El 94.5% delas mujeres se la han realizado por lo menos una vez. Este porcentaje es mayor en elrango de 40 a 60 años donde alcanza el 99%, y en las de menor edad este porcentajedisminuye. Al definir su utilidad: solo el 73.8% respondió de manera acertada. El 50%refieren aspectos desagradables en relación con la toma de la citología, como el miedoy el temor a un diagnóstico de cáncer y el olvido es el principal factor para no reclamarlos resultados. Estos datos demuestran que el porcentaje de mujeres con vida sexualque desconocen la utilidad de la citología o nunca se la han practicado es mínimo, locual permite concluir que la ineficacia de los programas de tamizaje para disminuir lascifras de cáncer de cérvix en nuestro medio depende de otros factores que deben serevaluados.

  9. Melanosis of the uterine cervix: a case report and literature review / Melanose cervical uterina: relato de caso e revisão da literatura

    Scientific Electronic Library Online (English)

    Daniel, Chang; Gerusa Biagione, Tiburzio.

    2013-06-01

    Full Text Available A melanose cervical uterina representa lesão melanocítica extremamente rara, devendo ser diferenciada do melanoma. Trata-se de uma hiperpigmentação melanocítica das células da camada basal da mucosa escamosa do colo uterino sem aumento no número de melanócitos. Apresenta-se, neste artigo, um caso ca [...] racterístico dessa entidade, além da discussão acerca das possíveis origens dos melanócitos nessa região, bem como sua relação com a síndrome de Laugier-Hunziker e o complexo de Carney. Abstract in english Melanosis of the uterine cervix is an extremely rare melanocytic lesion and should be differentiated from melanoma. It is a melanocytic hyperpigmentation of basal layer cells from the squamous mucosa of the uterine cervix without an increase in the number of melanocytes. We present a typical case of [...] this entity. Furthermore, we discuss the possible origins of melanocytes in this region and their association with Laugier-Hunziker syndrome and Carney complex.

  10. RAPIDARC (RA) in the uterine cervical cancer; dosimetric gain vs 3D-Crt

    International Nuclear Information System (INIS)

    This work aims to quantitatively assess RAPIDARC (RA) treatments versus three dimensional-Conformal Radiation Therapy with field to field technique (3D-Crt-Fin F). 11 patients with cervical cancer treated at our institution radically or adjuvant clinical stages I-III B were evaluated. The prescribed dose was 50 Gy (2 Gy / Fr). The RA plans consisted of two isocentric complete arcs and conformational plans of 4 isocentric fields (previous, subsequent, right side and left side) with 3D-Crt-Fin F technique; both cases carried out ??in the Eclipse version 10 planner with calculation algorithm analytical anisotropic algorithm (AAA) and volumetric optimization software (for VMAT plans). Homogeneity indices (Hi), conformity indices (CI) Sigma indices (S-Index), monitor units (MU) and the time required for each treatment were compared. The mean age was 52 years (32-65) of the 11 patients 9 were clinical stages I-II B. The Hi varied from 0.052 for RA to 0.163 for 3D-Crt-Fin F (p = 0.009), and the CI between 1.005 and 1.35 (p = 0.26), the S-index from 1.2 to 3.7 (p = 0.001) and the H-index of 1.08 to 1.15 (p = 0.24). All dose limits in risk organs were met with a significant difference in the RA plans versus 3D-Crt-Fin F. In patients with cervical cancer the treatment plans quality with the indices aforementioned seems to be better with the RA technique, being observed a significant reduction of radiation to surrounding organs. (author)

  11. Pre-treatment diffusion-weighted MR imaging for predicting tumor recurrence in uterine cervical cancer treated with concurrent chemoradiation: Value of histogram analysis of apparent diffusion coefficients

    International Nuclear Information System (INIS)

    To evaluate the value of apparent diffusion coefficient (ADC) histogram analysis for predicting tumor recurrence in patients with uterine cervical cancer treated with chemoradiation therapy (CRT). Our institutional review board approved this retrospective study and waived informed consent from each patient. Forty-two patients (mean age, 56 ± 14 years) with biopsy-proven uterine cervical squamous cell carcinoma who underwent both pre-treatment pelvic magnetic resonance imaging with a 3.0 T magnetic resonance scanner and concurrent CRT were included. All patients were followed-up for more than 6 months (mean, 36.4 ± 11.9 months; range 9.0-52.8 months) after completion of CRT. Baseline ADC parameters (mean ADC, 25th percentile, 50th percentile, and 75th percentile ADC values) of tumors were calculated and compared between the recurrence and no recurrence groups. In the recurrence group, the mean ADC and 75th percentile ADC values of tumors were significantly higher than those of the no recurrence group (p = 0.043 and p = 0.008, respectively). In multivariate analysis, the 75th percentile ADC value of tumors was a significant predictor for tumor recurrence (p = 0.009; hazard ratio, 1.319). When the cut-off value of the 75th percentile ADC (0.936 x 10-3 mm2/sec) was used, the overall recurrence free survival rate above the cut-off value was significantly lower than that below the cut-off value (51.9% vs. 91.7%, p = 0.003, log-rank test). Pre-CRT ADC histogram analysis may serve as a biomarker for predicting tumor recurrence in patients with uterine cervical cancer treated with CRT.

  12. Preoperative PET/CT FDG standardized uptake value of pelvic lymph nodes as a significant prognostic factor in patients with uterine cervical cancer

    International Nuclear Information System (INIS)

    Using integrated PET/CT, we evaluated the prognostic relevance in uterine cervical cancer of preoperative pelvic lymph node (LN) [18F]FDG uptake. Patients with FIGO stage IB to IIA uterine cervical cancer were imaged with FDG PET/CT before radical surgery. We used Cox proportional hazards regression to examine the relationship between recurrence and the FDG maximum standardized uptake value (SUVmax) in the pelvic LN (SUVLN) on PET/CT. Clinical data, treatment modalities, and results in 130 eligible patients were reviewed. The median postsurgical follow-up was 34 months (range 6 to 109 months). Receiver operating characteristic analysis identified SUVLN 2.36 as the most significant cut-off value for predicting recurrence. SUVLN was correlated with SUVtumour (P = 0.002), primary tumour size (P = 0.004), and parametrial invasion (P = 0.013). Univariate analyses showed significant associations between recurrence and SUVLN (P = 0.001), SUVtumour (P = 0.007), pelvic LN metastasis (P = 0.002), parametrial invasion (P LN (P = 0.013, hazard ratio, HR, 4.447, 95 % confidence interval, CI, 1.379 - 14.343) and parametrial invasion (P = 0.013, HR 6.728, 95 % CI 1.497 - 30.235) as independent risk factors for recurrence. Patients with SUVLN ?2.36 and SUVLN <2.36 differed significantly in terms of recurrence (HR 15.20, P < 0.001). Preoperative pelvic LN FDG uptake showed a strong significant association with uterine cervical cancer recurrence. (orig.)

  13. Pre-treatment diffusion-weighted MR imaging for predicting tumor recurrence in uterine cervical cancer treated with concurrent chemoradiation: Value of histogram analysis of apparent diffusion coefficients

    Energy Technology Data Exchange (ETDEWEB)

    Heo, Suk Hee; Kim, Jin Woong; Lim, Hyo Soon; Jeong, Yong Yeon; Kang, Woo Dae; KIm, Seok Mo; Kang, Heong Keun [Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun (Korea, Republic of); Shin, Sang Soo [Chonnam National University Hospital, Chonnam National University Medical School, Gwangju (Korea, Republic of)

    2013-08-15

    To evaluate the value of apparent diffusion coefficient (ADC) histogram analysis for predicting tumor recurrence in patients with uterine cervical cancer treated with chemoradiation therapy (CRT). Our institutional review board approved this retrospective study and waived informed consent from each patient. Forty-two patients (mean age, 56 ± 14 years) with biopsy-proven uterine cervical squamous cell carcinoma who underwent both pre-treatment pelvic magnetic resonance imaging with a 3.0 T magnetic resonance scanner and concurrent CRT were included. All patients were followed-up for more than 6 months (mean, 36.4 ± 11.9 months; range 9.0-52.8 months) after completion of CRT. Baseline ADC parameters (mean ADC, 25th percentile, 50th percentile, and 75th percentile ADC values) of tumors were calculated and compared between the recurrence and no recurrence groups. In the recurrence group, the mean ADC and 75th percentile ADC values of tumors were significantly higher than those of the no recurrence group (p = 0.043 and p = 0.008, respectively). In multivariate analysis, the 75th percentile ADC value of tumors was a significant predictor for tumor recurrence (p = 0.009; hazard ratio, 1.319). When the cut-off value of the 75th percentile ADC (0.936 x 10{sup -3} mm{sup 2}/sec) was used, the overall recurrence free survival rate above the cut-off value was significantly lower than that below the cut-off value (51.9% vs. 91.7%, p = 0.003, log-rank test). Pre-CRT ADC histogram analysis may serve as a biomarker for predicting tumor recurrence in patients with uterine cervical cancer treated with CRT.

  14. Preoperative PET/CT FDG standardized uptake value of pelvic lymph nodes as a significant prognostic factor in patients with uterine cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Hyun Hoon [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea, Republic of); Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Seoul (Korea, Republic of); Cheon, Gi Jeong; Kang, Keon Wook [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul (Korea, Republic of); Kim, Jae Weon; Park, Noh-Hyun [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea, Republic of); Song, Yong Sang [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea, Republic of); Seoul National University, WCU Biomodulation Major, Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul (Korea, Republic of)

    2014-04-15

    Using integrated PET/CT, we evaluated the prognostic relevance in uterine cervical cancer of preoperative pelvic lymph node (LN) [{sup 18}F]FDG uptake. Patients with FIGO stage IB to IIA uterine cervical cancer were imaged with FDG PET/CT before radical surgery. We used Cox proportional hazards regression to examine the relationship between recurrence and the FDG maximum standardized uptake value (SUV{sub max}) in the pelvic LN (SUV{sub LN}) on PET/CT. Clinical data, treatment modalities, and results in 130 eligible patients were reviewed. The median postsurgical follow-up was 34 months (range 6 to 109 months). Receiver operating characteristic analysis identified SUV{sub LN} 2.36 as the most significant cut-off value for predicting recurrence. SUV{sub LN} was correlated with SUV{sub tumour} (P = 0.002), primary tumour size (P = 0.004), and parametrial invasion (P = 0.013). Univariate analyses showed significant associations between recurrence and SUV{sub LN} (P = 0.001), SUV{sub tumour} (P = 0.007), pelvic LN metastasis (P = 0.002), parametrial invasion (P < 0.001), primary tumour size (P = 0.007), suspected LN metastasis on MRI (P = 0.024), and FIGO stage (P = 0.026). Multivariate analysis identified SUV{sub LN} (P = 0.013, hazard ratio, HR, 4.447, 95 % confidence interval, CI, 1.379 - 14.343) and parametrial invasion (P = 0.013, HR 6.728, 95 % CI 1.497 - 30.235) as independent risk factors for recurrence. Patients with SUV{sub LN} ?2.36 and SUV{sub LN} <2.36 differed significantly in terms of recurrence (HR 15.20, P < 0.001). Preoperative pelvic LN FDG uptake showed a strong significant association with uterine cervical cancer recurrence. (orig.)

  15. Interfractional change of high-risk CTV D90 during image-guided brachytherapy for uterine cervical cancer

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate interfractional changes of the minimum dose delivered to 90% of the high-risk clinical target volume (HR-CTV D90) and D2cc of the bladder and rectum during brachytherapy for uterine cervical cancer patients. A total of 52 patients received external beam radiotherapy and high-dose-rate intracavitary brachytherapy (ICBT). For each of four ICBT applications, a pelvic CT scan was performed and the HR-CTV was delineated. Retrospectively, these patients were divided into two groups: (1) the standard dose group with 6 Gy to point A in each ICBT, and (2) the adaptive dose group with a modified dose to point A to cover the HR-CTV with the 6-Gy isodose line as much as possible. The HR-CTV D90 was assessed in every session, and analyzed as interfractional changes. In the standard dose group, the interfractional changes of the HR-CTV D90 showed a linear increase from the first to the third of the four ICBT (average 6.1, 6.6, 7.0 and 7.1 Gy, respectively). In contrast, those of the adaptive dose group remained almost constant (average 7.2, 7.2, 7.3 and 7.4 Gy, respectively). Especially, in the case of a large HR-CTV volume (?35 cm3) at first ICBT, the total HR-CTV D90 of the adaptive dose group with brachytherapy was significantly higher than that of the standard dose group. There were no significant differences in total D2cc in bladder and rectum between the two groups. Image-guided adaptive brachytherapy based on interfractional tumor volume change improves the dose to the HR-CTV while keeping rectal and bladder doses within acceptable levels. (author)

  16. Do clinicians and patients agree regarding symptoms? A comparison after definitive radiochemotherapy in 223 uterine cervical cancer patients

    International Nuclear Information System (INIS)

    Background: In clinical cancer research of morbidity, low associations between clinician-assessed toxicity/morbidity and patient-reported symptoms are consistently described in the literature. While morbidity grading systems are supposed to follow more or less objective criteria, patient reported symptoms inherently are based on a subjective self-evaluation of the impact on quality of life. The aim of this study was to focus on major discrepancies with high clinical relevance and to evaluate its impact with regard to underreporting of morbidity. Material and methods: Early morbidity assessed by clinicians with CTCAEv.3 and patient reported quality of life (EORTC-QLQ-C30/CX24) were compared regarding 12 overlapping symptoms in 223 patients with uterine cervical cancer 3 months after definitive radio(chemo)therapy in the ongoing EMBRACE study. Mismatches showing discrepancies between both grading systems were classified, if patients reported substantial symptoms (quite a bit/very much) and CTCAE grading was rated G0. Results: In total, 360 substantial symptoms were reported by patients by EORTC-QLQ; 159 (44%) of those were not recognized by CTCAE. Symptoms with the highest occurrence of mismatches overall are urinary frequency, fatigue, and insomnia. Large institutional differences were found, showing two centers with 4 vs. 71% of patients with at least one mismatch. Conclusion: Analysis of mismatches indicated a high risk of underestimation of early morbidity. Thus, nederestimation of early morbidity. Thus, nearly half of the patient-reported substantial symptoms were not recognized by CTCAE scoring (G0) 3 months after treatment. Prospective assessment of morbidity in clinical studies should, therefore, integrate patient reported symptoms to receive a complete and comprehensive picture. (orig.)

  17. Do clinicians and patients agree regarding symptoms? A comparison after definitive radiochemotherapy in 223 uterine cervical cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Kirchheiner, K.; Poetter, R. [Medical Univ. Vienna (Austria). Dept. of Radiotherapy; Nout, R. [University Medical Center Leiden (Netherlands). Dept. of Clinical Oncology; Lindegaard, J. [University Hospital Aarhus (Denmark). Dept. of Oncology; Petric, P. [Institute of Oncology Ljubljana (Slovenia). Dept. of Radiotherapy; Limbergen, E.V. [University Hospital Leuven (Belgium). Dept. of Radiotherapy; Juergenliemk-Schulz, I.M. [University Medical Center Utrecht (Netherlands). Dept. of Radiation Oncology; Haie-Meder, C. [Institut Gustave-Roussy, Villejuif (France). Dept. of Radiotherapy; Doerr, W. [Technische Univ. Dresden (Germany). Dept. of Radiotherapy and Radiooncology

    2012-10-15

    Background: In clinical cancer research of morbidity, low associations between clinician-assessed toxicity/morbidity and patient-reported symptoms are consistently described in the literature. While morbidity grading systems are supposed to follow more or less objective criteria, patient reported symptoms inherently are based on a subjective self-evaluation of the impact on quality of life. The aim of this study was to focus on major discrepancies with high clinical relevance and to evaluate its impact with regard to underreporting of morbidity. Material and methods: Early morbidity assessed by clinicians with CTCAEv.3 and patient reported quality of life (EORTC-QLQ-C30/CX24) were compared regarding 12 overlapping symptoms in 223 patients with uterine cervical cancer 3 months after definitive radio(chemo)therapy in the ongoing EMBRACE study. Mismatches showing discrepancies between both grading systems were classified, if patients reported substantial symptoms (quite a bit/very much) and CTCAE grading was rated G0. Results: In total, 360 substantial symptoms were reported by patients by EORTC-QLQ; 159 (44%) of those were not recognized by CTCAE. Symptoms with the highest occurrence of mismatches overall are urinary frequency, fatigue, and insomnia. Large institutional differences were found, showing two centers with 4 vs. 71% of patients with at least one mismatch. Conclusion: Analysis of mismatches indicated a high risk of underestimation of early morbidity. Thus, nearly half of the patient-reported substantial symptoms were not recognized by CTCAE scoring (G0) 3 months after treatment. Prospective assessment of morbidity in clinical studies should, therefore, integrate patient reported symptoms to receive a complete and comprehensive picture. (orig.)

  18. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... We don't want to treat people with history of cervical cancer or uterine cancer. We have ... slow blood flow. Jim? All right, so that's perfect, Alex. So what we saw here was a ...

  19. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... We don't want to treat people with history of cervical cancer or uterine cancer. We have ... it has that rich blood supply. And, of course, that's what causes part of the symptoms. And ...

  20. Reporting radiotherapeutic complications in patients with uterine cervical cancer. The importance of latency and classification system

    DEFF Research Database (Denmark)

    Pedersen, D; Bentzen, SØren M

    1993-01-01

    Radiotherapeutic morbidity is reported according to our own system (AADK) and the Franco-Italian glossary (FI) in 442 patients with cervical cancer FIGO stage IIB (139), IIIA (10), IIIB (221), and IVA (72). The AADK system records each symptom, date of appearance, the required therapy, and its initial date. FI describes the maximal damage in 4 grades. Actuarial estimates of moderate or worse complications in the rectosigmoideum differed significantly in relation to stage, while frequencies did not differ. Frequencies were up to 25% lower than the actuarial estimates. Moderate AADK complications in the rectosigmoideum occurred from 1 to more than 24 months in 42% of stage IIIB patients finally developing severe FI complications, and during more than 2 years in 24% of the patients dying from rectosigmoid complications. An analysis of the probability of being alive without moderate or worse AADK complications indicated that survival and complications were unrelated. It is concluded that, with any classification system for reporting morbidity, each symptom and required therapy used in the definition of each complication grade and the date of appearance should be registered regularly to allow (1) reporting of the real risk of organ damage, (2) rescoring of complication grades, (3) separation of early and late morbidity, and (4) reporting of actuarial estimates. If these minimum requirements are met, underestimation of morbidity is avoided.

  1. Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer

    Science.gov (United States)

    2014-12-29

    Lymphedema; Stage 0 Cervical Cancer; Stage 0 Uterine Corpus Cancer; Stage 0 Vulvar Cancer; Stage I Uterine Corpus Cancer; Stage I Vulvar Cancer; Stage IA Cervical Cancer; Stage IB Cervical Cancer; Stage II Uterine Corpus Cancer; Stage II Vulvar Cancer; Stage IIA Cervical Cancer; Stage IIB Cervical Cancer; Stage III Cervical Cancer; Stage III Uterine Corpus Cancer; Stage III Vulvar Cancer; Stage IV Uterine Corpus Cancer; Stage IVA Cervical Cancer; Stage IVB Cervical Cancer; Stage IVB Vulvar Cancer

  2. Transition of Ki-67 index of uterine cervical tumors during radiation therapy. Immunohistochemical study

    International Nuclear Information System (INIS)

    Histopathologic and Ki-67-staining features of cancer cells were investigated in biopsy specimens before and during radiation therapy in 29 patients with cervical squamous cell carcinoma. No morphologic changes were observed up to doses of 540 cGy. A few intact cancer cells remained up to doses of 2700 cGy. Moderate changes in the cancer cells were noticed in patients who received 900 cGy or more, i.e., multinuclei, swollen nuclei and cytoplasms, and prominent large nucleoli. At doses of 1800 cGy or greater, many cancer nests had severely damaged cancer cells with features such as cytolysis, karyolysis, karyorrhexis, pyknosis, and bizarre giant cells. There was no mitosis in the cells of patients who received doses greater than 1800 cGy. The Ki-67-positive cancer cells showed diffuse nuclear-stainings and dot-stainings before radiation therapy. Radiation doses more than 900 cGy changed the staining pattern of the Ki-67 antibody; large irregular spot-stainings and ring-stainings were observed predominantly. The Ki-67 index initially increased with the radiation dose; the mean Ki-67 indices before radiation therapy and at radiation doses of 180 cGy, 540 cGy, and 900 cGy were 41%, 50%, 63%, and 68%, respectively. The indices decreased when the dose was increased further, and they were 39% and 20% at doses of 1800 cGy and 2700 cGy, respectively. Possible explanations, including recruitment of quiescent cells, for the change in Ki-67 staining are discussed67 staining are discussed

  3. Vírus HPV e câncer de colo de útero / Human Papillomavirus (HPV) and uterine cervical cancer / Virus HPV y el cáncer del cuello uterino

    Scientific Electronic Library Online (English)

    Janete Tamani Tomiyoshi, Nakagawa; Janine, Schirmer; Márcia, Barbieri.

    2010-04-01

    Full Text Available Este artigo refere-se a uma revisão de literatura sobre o vírus HPV e câncer de colo de útero, com o objetivo de levantar aspectos da infecção do vírus que influenciam no curso natural do câncer de colo de útero tais como: a tipologia do vírus, a duração e a persistência da infecção além de associar [...] com as manifestações das lesões precursoras até a evolução da neoplasia. Foi possível constatar a forte associação da infecção com a evolução da neoplasia cervical, no entanto, ainda são necessários estudos que elucidem melhor certos aspectos da infecção do vírus HPV que agem sobre o colo do útero para que as ações de prevenção e combate a doença sejam mais eficazes. Abstract in spanish Este artículo se refiere a una revisión de literatura sobre el virus HPV y la neoplasia cervical, con el objetivo de levantar aspectos de la infección del virus que influye en el curso natural del cáncer de cuello del útero tales como: la tipologia del virus, la duración y la persistencia de la infe [...] cción además de asociarlo a las manifestaciones de las lesiones precursoras hasta la evolución de la neoplasia. Ha sido posible constatar la fuerte asosiación de la infección con la evolución de la neoplasia cervical, entretanto, aún son necesarios estudios que eluciden mejor ciertos aspectos de la infección del virus HPV que actúa sobre el cuello del útero para que las acciones de prevención y combate a la enfermedad sean más eficaces. Abstract in english This article refers to a review of literature about the HPV virus and the cervical neoplasia, aiming at raising aspects of the virus infection which influences in the natural development of the uterine cervical cancer such as: the type of virus, the duration and the persistence of the infection and [...] also the association with the manifestations of the preceding lesions up to the evolution of the neoplasia. It was possible to notice the strong association of the infection with the evolution of the cervical neoplasia, however, studies to better elucidate certain aspects of the infection of the HPV virus that acts on the uterine cervix are still necessary so that the actions of prevention and fight against the disease will be more efficient.

  4. Therapeutic comparison of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages I b2-II a cervical cancer

    International Nuclear Information System (INIS)

    Objective: To compare the short-term and long-term therapeutic response of uterine artery chemoembolization with internal iliac anterior trunk arterial chemotherapy performed before radical hysterectomy in patients with stages I b2-II a cervical cancer. Methods: One hundred and fifty-one patients with stages I b2-II a cervical cancer were treated with preoperative intra-arterial chemotherapy before radical hysterectomy was carried out. Patients in study group (n = 113) received uterine artery chemoembolization (UACE), while patients control group(n = 38) received internal iliac anterior trunk arterial chemotherapy. Radical hysterectomy was carried out in all patients within 2-4 weeks after UACE or chemotherapy. The tumor size was measured before and after the procedure,and the survival rate at 2 and 5 years after treatment was calculated. Results: The mean maximum diameter of the tumors was (4.58 ± 0.37) cm before interventional therapy, and it was (2.11 ± 0.24) cm in two weeks after interventional therapy. The complete response rate of study group and control group was 31.9% and 21.1% respectively. The total effective rate of study group and control group was 94.7% (107/113) and 76.3% (29/38) respectively. The effective rate of study group two weeks after therapy was significantly higher than that of control group. No surgical margin infiltration was observed in both groups. Pathological findings in study group included vascular invasion around surgical margin (n =lar invasion around surgical margin (n = 3), parametrial invasion (n = 5) and pelvic lymph node metastasis (n = 6), while in control group vascular invasion around surgical margin, parametrial invasion and pelvic lymph node metastasis were found in one, two and one cases respectively. The two-year and five-year survival rate in study group were 80.9% (68/84) and 73.4% (47/64) respectively, while the two-year and five-year survival rate in control group were 81.3% (26/32) and 75.0% (18/24) respectively. No significant difference in survival rate existed between two groups. Conclusion: Uterine artery chemoembolization can markedly reduce the volume of cervical cancer,which is very helpful for surgical resection. The therapeutic effectiveness of UACE is superior to internal iliac anterior trunk arterial chemotherapy, therefore, UACE should be regarded as neo-adjuvant intra-arterial chemotherapy of first choice for patients with stages I b2-II a cervical cancer. (authors)

  5. EVALUATION OF P16INK4A PROTEIN AS A BIOMARKER FOR CERVICAL INTRAEPITHELIAL NEOPLASIA AND SQUAMOUS CELL CARCINOMA OF THE UTERINE CERVIX

    Directory of Open Access Journals (Sweden)

    Biljana ?or?evi?

    2011-06-01

    Full Text Available The association of human papilloma virus (HPV infection and cervical intraepithelial neoplasia (CIN is well known. Interaction of HPV proteins with cellular regulatory proteins leads to up regulation of p16INK4A. The aim of this study was to evaluate p16INK4A protein as a biomarker for CIN lesions and squamous cell carcinoma on biopsy specimens of patients who underwent biopsy of the uterine cervix due to abnormal cytological finding.The authors analyzed biopsies from 50 patients with CIN and invasive squamous cell carcinoma of the uterine cervix. Expression of p16INK4A in CIN and invasive squamous cell carcinoma was immunohistochemically analyzed by using monoclonal anti-p16INK4A antibody.A total of 50 patients with CIN and invasive squamous cell carcinoma of the uterine cervix (mean age 40.2±11.5 years, range 20-74 years were analyzed. CIN I lesions were found in 27 (54%, CIN II/CIN III lesions in 9 (18%, and invasive squamous cell carcinoma in 14 (28% patients. Differences in the expression of p16INK4A between CIN I, CIN II/CIN III and squamous cell carcinoma were statistically significant (p<0.0001. Expression of p16INK4A showed low sensitivity (7%, specificity (8%, positive predictive value (8%, and negative predictive value (7% for CIN I. Sensitivity, specificity, positive predictive value, and negative predictive value of p16INK4A were 78%, 61%, 30%, and 93% for CIN II/CIN III, and 100%, 75%, 61%, and 100% for squamous cell carcinoma, respectively.Results of this study suggest that p16INK4A protein may be a sensitive biomarker for CIN II/CIN III lesions and invasive squamous cell carcinoma of the uterine cervix.

  6. Análisis de expresión global del cáncer cérvico uterino: rutas metabólicas y genes alterados / Global expression analysis in uterine cervical cancer: Metabolic pathways and altered genes

    Scientific Electronic Library Online (English)

    Guelaguetza, Vázquez-Ortíz; Patricia, Piña-Sanchez; Alfredo, Hidalgo; Minerva, Lazos; José, Moreno; Isabel, Alvarado; Fernando, Cruz; Dulce M, Hernández; Carlos, Pérez-Plascencia; Mauricio, Salcedo.

    2005-06-01

    Full Text Available La infección por virus de papiloma de alto riesgo (VPH) es considerada como el factor etiológico más importante del cáncer cérvico uterino (CaCU). Con el fin de determinar el patrón de expresión global e identificar algunos posibles genes marcadores del CaCU, se utilizaron microhileras de DNA que co [...] ntenían 8,000 secuencias que codificaban para transcritos diferentes, para estudiar los perfiles de expresión de cinco líneas celulares derivadas de CaCU, tres muestras tumorales conteniendo VPH 16 y tres muestras normales negativas para la presencia de VPH. Se identificaron los niveles de expresión de genes relacionados con diferentes rutas metabólicas. Se llevó a cabo el análisis de agrupamiento jerárquico y posteriormente se confirmó la sobrexpresión de dos genes mediante RT-PCR. Estos dos genes se encontraron sobrexpresados en biopsias tumorales cervicales. Uno de ellos, el gen de IL6, que ha sido previamente reportado en relación con CaCU, así como el gen de la matriz-metaloproteasa 10 (MMP10) por primera vez relacionado con esta neoplasia. El análisis de agrupamiento jerárquico, además, reveló que las muestras que contienen el mismo tipo viral están asociadas, sugiriendo posibles diferencias en expresión entre tipos virales. Abstract in english High risk human papillomavirus (HPV) infection is considered to be the most important etiological factor of Cervical Uterine Cancer. In order to determine the global expression pattern and to identify possible molecular markers of cervical cancer, cDNA arrays with probe sets complementary to 8,000 h [...] uman genes were used to examine the expression profiles among 5 cell lines derived from human cervical cancer, three HPV16(+) tumor samples and three normal cervical tissues HPV(-). The levels of expression of different cellular processes were identified. Hierarchical clustering was performed and the gene expression using RT-PCR was confirmed. Two genes were found to be consistently overexpressed in invasive cervical cancer biopsies; one of them, IL-6 was previously reported to be overexpressed in cervical cancer and one novel gene, MMP10, previously not known to be related to cervical cancer. Hierarchical clustering of the expression data revealed that samples with common HPV type infection grouped together, maybe this could mean that differences between HPV types could be indirectly determined by expression profiles.

  7. Increase in rectal dose by variance in administration of Fletcher-Suit applicator during intracavitary high dose rate brachytherapy for uterine cervical cancer

    International Nuclear Information System (INIS)

    To assess variability of the radiation dose to the rectum in manual applicator insertion for uterine cervical cancer treatment, we retrospectively surveyed the dose at the rectal evaluation point (RED) presumed in 175 planning sessions of intracavitary high dose rate brachytherapy performed in 43 patients. A wide variation was found in RED from 52 to 308% of the prescribed dose with a mean of 144%. Posterior flexure of the tandem increased RED 16% in average, and lack of vaginal gauge packing did 19%. The distance of colpostats had a significantly negative relationship with RED. In this study we found significant variation in the rectal exposure by the manual insertion procedure, and it may induce late intractable side effects. (author)

  8. Características clínico patológicas del cáncer de cérvix uterino recurrente después de cirugía radical primaria. / Clinical and pathological features of recurrent uterine cervical cancer after primary radical surgery

    Scientific Electronic Library Online (English)

    Pedro, Aguilar; Henry, Valdivia.

    2012-03-01

    Full Text Available Objetivo: Describir las características clínico patológicas del cáncer de cérvix uterino recurrente, sitio y tiempo de recurrencia, y sobrevida después de la recurrencia de acuerdo a las variables de pronóstico en pacientes con cirugía radical primaria. Material y métodos: Estudio descriptivo, obser [...] vacional y retrospectivo, tipo serie de casos, realizado en el Instituto Nacional de Enfermedades Neoplásicas de Lima Perú entre 1990 y 2005. Se incluyeron todas las pacientes con cáncer de cérvix uterino estadios IB1 y IIA a quienes se les realizó cirugía radical primaria y que tuvieron recurrencia. Las curvas de sobrevida fueron construidas con el método de Kaplan-Meier. Resultados: Se realizaron 609 histerectomías radicales tipo III, 53(8,7%) tuvieron recurrencia. La edad promedio al diagnóstico de la recurrencia fue 44,5 años, el tiempo medio desde la cirugía hasta la recurrencia 18,9 meses y el sitio de recurrencia más frecuente fue a distancia (41,5%) seguido por recurrencia central y pélvica. El sitio de recurrencia y los márgenes quirúrgicos tuvieron significancia estadística con respecto al tiempo de recurrencia. La terapia de salvataje más frecuente fue la radioterapia (45%). La sobrevida promedio después de la recurrencia fue 26,9 meses y la tasa de sobrevida a 5 años 9,4%. Conclusiones: El cáncer cervical recurrente es poco frecuente, afecta a mujeres jóvenes y el sitio de recurrencia más frecuente es metástasis a distancia. El tiempo de recurrencia es más corto cuando la recurrencia es central y los márgenes quirúrgicos están afectados. La sobrevida después de la recurrencia en cáncer cervical tratado con cirugía radical es baja. Abstract in english Objective: To describe clinical and pathological features of recurrent uterine cervical cancer, including site and time to recurrence and survival after primary radical surgery. Methods: Descriptive, observational case series study conducted at the Instituto Nacional de Enfermedades Neoplásicas in L [...] ima between 1990 and 2005. Patients with recurrent uterine cervical cancer stages IB1 and IIA who had been treated with primary surgical resection were included. Kaplan-Meir survival curves were constructed. Results: 609 radical hysterectomies type II were performed; 53 (8.7%) had a recurrence. Mean age at diagnosis of recurrence was 44.5 years; mean time from surgery to recurrence was 18.9 months, and the most common site for recurrence was distant recurrence (415%), followed by central recurrence and pelvic recurrence. Site of recurrence and surgical margins had statistical association with time to recurrence. The most frequent salvage therapy was radiotherapy (45%). Mean survival time after recurrence was 26.9 months, and survival rate at 5 years was 9.4%. Conclusions: Recurrent uterine cervical cancer is not frequent, its affects young females causing distant metastasis mainly. Time to recurrence is shorter when recurrence is central and surgical margins are involved. Survival time after recurrence in patients treated surgically is short.

  9. Dose to the non-involved uterine corpus with MRI guided brachytherapy in locally advanced cervical cancer

    DEFF Research Database (Denmark)

    Sapru, Shantanu; Mohamed, Sandy

    2013-01-01

    BACKGROUND AND PURPOSE: This study evaluates the impact of MRI guided adaptive brachytherapy (BT) on uterine corpus dose. MATERIAL AND METHODS: 84 patients with median follow-up of 18 months were analysed. MRI based BT was done according to GEC-ESTRO guidelines. Non-involved uterine corpus at the time of BT was contoured and the uterine corpus dose (D90 and D98) was evaluated for (1) standard loading pattern with source loading to the tip of the tandem and (2) optimised dose plan. Tandem lengths and heights of the 85 Gy isodose were recorded. RESULTS: Dose optimisation resulted in a reduction of active tandem length of 0.4±0.4 cm leading to lowering the D90 to the non-involved uterine corpus from 63.8±9.5 Gy to 56.7±7.5 Gy EQD2 (p<0.0001). Mean active tandem length was 5.0±1.0 cm, and the height of the 85 Gy isodose was 5.7±1.0 cm in optimised plans. CONCLUSIONS: MRI guided dose optimisation lowered the dose to the uterine corpus. However, a total EBRT+BT dose larger than 50 Gy was obtained in 99% of patients. Assuming that 45-50 Gy is sufficient to eradicate microscopic disease, the lowering of uterus corpus dose is not expected to induce additional uterine corpus recurrences in the setting of MRI guided adaptive BT. This hypothesis should be tested in a larger number of patients as e.g. the EMBRACE study.

  10. Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino / Human papillomavirus genotyping of cervical uterine preneoplastic lesions in a high risk area

    Scientific Electronic Library Online (English)

    JAIME, LÓPEZ M; CARMEN GLORIA, ILI G; PRISCILLA, BREBI M; PATRICIA, GARCÍA M; ITALO, CAPURRO V; PABLO, GUZMÁN G; EUGENIO, SUÁREZ P; JOSÉ MANUEL, OJEDA F; JUAN CARLOS, ROA S.

    1343-13-01

    Full Text Available [...] Abstract in english The relationship between human papillomavirus (HPV) and uterine cervical cancer (UCC) is widely known and accepted. Aim: To determine the frequency of genotypes of HPV in cervical preneoplastic lesions in a high risk area of UCC. Material and Methods: Using a combination of PCR and Reverse Line Blot [...] technique, 235 formalin fixed paraffin embedded samples, with diagnosis of low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL) were genotyped. Results: HPV was detected in 61.2% of LSIL and 78.1% of HSIL. The main genotypes found were HPV 16, 18, 31, 45, 56 y 58. HPV 16 was the most common in both LSIL (18.1%) and HSIL (36.9%). HPV 16 or 18 were present in 25.1% and 47.1% of the LSIL and HSIL respectively. In both LSIL and HSIL, the predominant viral genotypes were those types classified as with a high oncogenic risk. Conclusions: HPV genotypes 16, 18, 31, 45, 56 y 58 were the most common in our series. HPV 16 and 18, viral types with high oncogenic risk and included in commercial vaccines, were found in 25.1% and 47.1% of LSIL and HSIL, respectively.

  11. Human papilloma virus early proteins E6 (HPV16/18-E6) and the cell cycle marker P16 (INK4a) are useful prognostic markers in uterine cervical carcinomas in Qassim Region--Saudi Arabia.

    Science.gov (United States)

    Omran, O M; AlSheeha, M

    2015-01-01

    Cervical cancer is a common and an important public health problem for adult women in developing countries. In contrast, cervical cancer incidence is low in Saudi Arabia. High-risk types of human papilloma viruses (HPV16 and HPV18) are the most significant risk factors for cervical cancer. HPV16/18-E6 oncoprotein is associated with HPV etiology, viral persistence and epithelial transformation. Cell cycle protein p16 INK4a (p16) plays an important role in the pathophysiology of cervical carcinomas. The aims of this study were to investigate the expression of HPV16/18-E6 and p16 in uterine cervical carcinomas in Qassim Region--Saudi Arabia, and to relate the results to the established clinicopathological prognostic parameters (age of the patient, educational level, birth control methods, number of pregnancy, smoking status, degree of histological differentiation, clinical stage, and lymph node metastasis) The study included 40 specimens of uterine cervical squamous cell carcinomas diagnosed and confirmed by biopsy. Histopathological classification of cervical tumors cases was performed according to the International Federation of Gynecology and Obstetrics (FIGO). Immunohistochemical analysis for HPV16/18-E6 and p16 were carried out on formalin-fixed paraffin-embedded sections of cervical tissues using avidin-biotin peroxidase method. There was a significant statistical correlation between HPV16/18-E6 expression in cervical carcinoma and nationality, smoking status and size of the tumor. HPV16/18-E6 oncoprotein expression in normal lymphocytes and endothelial cells in the tumor tissues and the adjacent normal cervical tissues suggest the possibility that HPV infection might spread to other organs through blood circulation. P16 expression has been correlated with high grade, stage of cervical SCC and HPV16/18-E6 expression. The current study supports the critical function of p16 and HPV16/18-E6 as specific markers for cervical carcinoma. However the potential for usage of p16 and HPV16/18-E6 as prognostic markers will require detailed follow data for a larger group of patients. PMID:24925218

  12. Studies on combined effect of irradiation with CDDP and BLM in cultured cells from uterine cervical cancer

    International Nuclear Information System (INIS)

    The purpose is to examine the combined effect of irradiation with anticancer drugs on uterine cancer, SKG-IIIb cells, cultured from squamous cell carcinoma of uterine cervix, were used in this study. Anticancer drugs were CDDP 1 ?g/ml, BLM 10 ?g/ml, and the radiation was 60Co 0.5 Gy. The results were as follows: The growth of cells was the most strongly suppressed by the exposure to radiation after CDDP administration. By the exposure to radiation after anticancer drugs administration, the morphorogic damage of cells was revealed both by a light microscope and a scanning electron microscope. Flow cytometric measurement revealed that anticancer drugs changed DNA distributions of cells: the accumulation of exposed cells in S phase was showed and the cell cycle progression was delayed. DNA histograms showed no accumulation of cells in G2+M phase that were most effective phase to irradiation in 24 hours after anticancer drugs administration, but partial synchronization in G2+M phase in 48 hours after BLM administration. These results indicate that the combined therapy of anticancer drugs and irradiation on uterine cancer is effective and timely irradiation will be more effective. (author)

  13. La promoción de salud dirigida a reducir los factores de riesgo de cáncer cérvico uterino / Health promotion aimed to reducing uterine cervical cancer risk factors

    Scientific Electronic Library Online (English)

    Misleny, Martínez Pérez; Juan Carlos, de la Concepción Cárdenas; Ariel, Pérez González.

    2014-06-01

    Full Text Available La primera Conferencia Internacional sobre la Promoción de la Salud celebrada en Ottawa, el 21 de noviembre de 1986, definió la promoción de la salud como “el proceso de permitir a la gente aumentar su control sobre su salud y por lo tanto mejorarla”. Se reconoce claramente que la promoción de la sa [...] lud va más allá de los estilos de vida, en la cual la educación para la salud constituye, junto a la comunicación y a la participación social, herramientas necesarias para su instrumentación en el primer nivel de atención. En la práctica cotidiana se desconoce de forma reiterada el valor que tiene el reconocimiento adecuado de las dimensiones de la promoción de salud, desde una perspectiva holística, dirigidas a reducir los factores de riesgo de cáncer cérvico uterino. El propósito del estudio fue realizar una contribución teórica a la promoción de salud para contribuir al fortalecimiento del Programa Nacional de Diagnóstico Precoz del Cáncer Cérvico Uterino. Al considerar el valor de esta disciplina desde sus dimensiones, el profesional de la salud dispone de una base teórica que guíe las acciones dirigidas a la reducción de factores de riesgos de este tipo de cáncer en la población femenina. Abstract in english The first International Conference on Health Promotion celebrated in Ottawa on November 21st, 1986, defined health promotion as “the process allowing people to increase the control on their health and therefore to improve it”. It is clearly understood that health promotion goes beyond life styles, a [...] nd also includes education for health, communication and social participation, necessary tools for its instrumentation in the first health care level. In every day practice it is continually not recognized the value of the adequate acknowledgement of health promotion dimensions, from a holistic perspective, aimed to reducing the uterine cervical cancer risk factors. The purpose of the research was theoretically contributing to the strengthening of the National Program of Uterine Cervical Cancer Precocious Diagnosis. When considering the value of this discipline in all its dimensions, the health care professional has a theoretical base to guide the actions aimed to reducing the risk factors of this kind of cancer among the female population.

  14. Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy; Aberracoes cromossomicas instaveis em linfocitos de pacientes com cancer de colo de utero

    Energy Technology Data Exchange (ETDEWEB)

    Magnata, Simey de Souza Leao Pereira

    2002-09-01

    Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of {sup 69} Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

  15. Cerebral metastasis of cervical uterine cancer: report of three cases / Metástases cerebrais de câncer de colo de útero: relato de três casos

    Scientific Electronic Library Online (English)

    Joacir Graciolli, Cordeiro; Daniel Monte-Serrat, Prevedello; Léo Fernando da Silva, Ditzel; Carlos Umberto, Pereira; João Cândido, Araújo.

    2006-06-01

    Full Text Available Tumores do cólo uterino se disseminam por contigüidade ou via hematogênica (pulmão, fígado e ossos). Metástases para sistema nervoso central são incomuns. Apenas cerca de 80 casos são citados na literatura. Manifestações clínicas são devidas à hipertensão intracraniana e a déficits focais. A sobrevi [...] da varia de 3 a 6 meses. Três casos são relatados sendo um infratentorial e dois supratentoriais. No primeiro, o diagnóstico da metástase antecedeu o da lesão uterina. No segundo, houve 5 anos sem recidiva após a cirurgia, fato este inédito. O tratamento foi cirurgia, radioterapia e/ou quimioterapia. A discussão enfatiza manejo multidisciplinar destas raras lesões. Abstract in english Cervical uterine cancer (CUC) spreads locally (pelvis and paraortic lymphnodes) or distantly (lungs, liver and bones). Metastasis to central nervous system (CNS) are rare. There are about 80 cases reported in the literature. Outcome is poor and survival varies from 3 to 6 months. Three cases of CNS [...] metastasis from CUC are reported, one infratentorial and two supratentorials in location. In one patient, the initial manifestation was due to the cerebral lesion, a feature reported for the first time. All cases were treated by surgery, radiotherapy and/or chemotherapy. Clinical findings and treatment options of these rare lesions are reviewed.

  16. Cerebral metastasis of cervical uterine cancer: report of three cases Metástases cerebrais de câncer de colo de útero: relato de três casos

    Directory of Open Access Journals (Sweden)

    Joacir Graciolli Cordeiro

    2006-06-01

    Full Text Available Cervical uterine cancer (CUC spreads locally (pelvis and paraortic lymphnodes or distantly (lungs, liver and bones. Metastasis to central nervous system (CNS are rare. There are about 80 cases reported in the literature. Outcome is poor and survival varies from 3 to 6 months. Three cases of CNS metastasis from CUC are reported, one infratentorial and two supratentorials in location. In one patient, the initial manifestation was due to the cerebral lesion, a feature reported for the first time. All cases were treated by surgery, radiotherapy and/or chemotherapy. Clinical findings and treatment options of these rare lesions are reviewed.Tumores do cólo uterino se disseminam por contigüidade ou via hematogênica (pulmão, fígado e ossos. Metástases para sistema nervoso central são incomuns. Apenas cerca de 80 casos são citados na literatura. Manifestações clínicas são devidas à hipertensão intracraniana e a déficits focais. A sobrevida varia de 3 a 6 meses. Três casos são relatados sendo um infratentorial e dois supratentoriais. No primeiro, o diagnóstico da metástase antecedeu o da lesão uterina. No segundo, houve 5 anos sem recidiva após a cirurgia, fato este inédito. O tratamento foi cirurgia, radioterapia e/ou quimioterapia. A discussão enfatiza manejo multidisciplinar destas raras lesões.

  17. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... people with history of cervical cancer or uterine cancer. We have to make sure that your symptoms are from your fibroids and they're not from other things such as endometriosis and other types of polyps and tumors that can occur in ...

  18. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... We don't want to treat people with history of cervical cancer or uterine cancer. We have to make sure that your symptoms are from your fibroids and they're not from other things such as endometriosis and other types of polyps ...

  19. Tendência da mortalidade por câncer do útero no Município de São Paulo entre 1980 e 1999 Mortality trends from uterine cervical cancer in the city of São Paulo from 1980 to 1999

    Directory of Open Access Journals (Sweden)

    Luiz Augusto Marcondes Fonseca

    2004-02-01

    Full Text Available O câncer do colo do útero apresenta grande incidência em algumas cidades brasileiras e considerável mortalidade em países em desenvolvimento, não obstante a disponibilidade já antiga de teste de rastreamento. O presente estudo visou avaliar a tendência da mortalidade por câncer de colo do útero, de corpo do útero e por câncer do útero não especificado, no Município de São Paulo, entre 1980 e 1999, por meio do exame das taxas brutas, idade-específica e ajustadas por idade. Os resultados mostraram discreta redução da mortalidade por câncer do colo do útero, queda da mortalidade por câncer de útero não especificado e aumento da mortalidade por câncer do corpo do útero. Conclui-se que a queda da mortalidade por câncer do útero não especificado sinaliza uma melhora na precisão do diagnóstico clínico e na qualidade do preenchimento do atestado de óbito, e indica aumento de cobertura do teste de Papanicolaou.Uterine cervical cancer shows a higher incidence in some Brazilian cities. It is a common cause of death in women from developing countries, despite the longstanding availability of an effective screening test, the Pap smear. This study aimed to evaluate the temporal trends of crude, age-adjusted, and age-specific mortality rates from cervical cancer, endometrial cancer, and cancer of the uterus not otherwise specified (NOS in the city of São Paulo from 1980 to 1999. Results showed a slight reduction in cervical cancer rates, a decrease in NOS uterine cancer rates, and an increase in endometrial cancer mortality rates. The fall in mortality from NOS uterine cancer indicates an improvement in diagnostic accuracy and quality of information on death certificates and may point to an increase in coverage of cervical cancer screening using the Pap smear.

  20. Mulheres vivenciando o adoecer em face do câncer cérvico-uterino Mujeres que viven la experiencia de enfermedad en la presencia de cáncer cervical-uterino Women living the experience of illness in the presence of cervical-uterine cancer

    Directory of Open Access Journals (Sweden)

    Mariza Silva de Oliveira

    2005-06-01

    Full Text Available O câncer cérvico-uterino é uma doença de alta incidência e prevalência no país. Com este estudo objetivou-se compreender as vivências de mulheres em face do processo de adoecer por câncer cérvico-uterino. Estudo descritivo exploratório realizado durante o primeiro trimestre de 2002 em serviço de referência ao atendimento de neoplasias de Fortaleza-CE. Foram pesquisadas vinte mulheres com câncer cérvico-uterino mediante entrevista semi-estruturada, cujas respostas foram assim categorizadas: 1. barreiras que dificultaram a prevenção; 2. enfrentamentos: da consulta ao diagnóstico de câncer; 3. desconhecimento sobre a evolução da doença; e 4. apego às pessoas e à religiosidade. Segundo evidenciaram os resultados, a maioria era proveniente do interior do Estado, com idade entre 30 e 50 anos; 75% possuíam ensino médio; 85% viviam com um a dois salários mínimos e 45% não haviam realizado o Papanicolaou. Diante da doença, indicaram sentimentos como ansiedade, medo e pânico. Também referiram desinformação e disseram recorrer à religião como estratégia para enfrentar o câncer. Alguns fatores de risco foram mencionados, sobressaindo: ausência e não adesão ao exame preventivo, convívio com escassos recursos socioeconômicos e dificuldades de acesso aos serviços de saúde.El cáncer cervical-uterino es una enfermedad de incidencia alta y predominio en Brasil. El objetivo del estudio presente era entender qué mujeres experimentan al enfrentar el proceso de volverse la deuda enferma al cáncer cervical-uterino. Un estudio exploratorio descriptivo se llevó a cabo en el primer trimestre de 2002 a una referencia repare para el cuidado de cáncer en Fortaleza-CE. Se investigaron veinte mujeres con el cáncer cervical-uterino por medio de una entrevista semi-estructurada, con las contestaciones a categorizándose como sigue: 1. barreras que dañan la prevención; 2. cubriendo: de la visita al diagnóstico de cáncer; 3. falte de conocimiento sobre el curso de la enfermedad; y 4. la atadura a las personas y a la religiosidad. Los resultados mostraron que la mayoría de las mujeres era del interior del Estado y era 30 a 50 años viejo; 75% tenían la media educación escolar; 85% vivieron encendido a dos salario mínimo, y 45% no habían sometido a una prueba de Papanicolaou. Al enfrentar la enfermedad, ellos indicaron sentimientos de ansiedad, miedo y pánico. Ellos también informaron falta de información y declararon que ellos se repitieron a la religión como una estrategia cubrir con el cáncer. Algunos factores de riesgo fueron mencionados, el más importante entre ellos: la ausencia de un examen preventivo o falta de complacencia con él, viviendo con las personas de recursos socio-económicos escasos, y dificultad de acceso a los servicios de salud.Cervical-uterine cancer is a disease of high incidence and prevalence in Brazil. The objective of the present study was to understand what women experience when facing the process of becoming ill due to cervical-uterine cancer. A descriptive exploratory study was carried out in the first trimester of 2002 at a reference service for cancer care in Fortaleza-CE. Twenty women with cervical-uterine cancer were investigated by means of a semi-structured interview, with the responses being categorized as follows: 1. barriers that impair prevention; 2. coping: from the visit to the diagnosis of cancer; 3. lack of knowledge about the course of the disease; and 4. attachment to people and to religiosity. The results showed that most women were from the interior of the State and were 30 to 50 years old; 75% had middle school education; 85% lived on one to two minimum wages, and 45% had not submitted to a Papanicolaou test. When facing the disease, they indicated feelings of anxiety, fear and panic. They also reported lack of information and stated that they recurred to religion as a strategy to cope with cancer. Some risk factors were mentioned, the most important among them: absence of a preventive examination or lack of compliance wi

  1. Results of radiotherapy for stage III uterine cervical carcinomas and preliminary study of combined radiotherapy and transarterial infusion chemotherapy

    International Nuclear Information System (INIS)

    This is a retrospective analysis of 55 patients with stage III carcinoma of the uterine cervix treated with radiation from November 1984 through December 1991. Eleven of the patients were treated with radiation and transarterial infusion chemotherapy (TAI), using cis-platinum and pepleomycin. The 3- and 5-year cumulative survival rates for all patients were 61% and 58%, respectively, and the 3-year cumulative survival rate for the group with combined radiation and TAI was 47%. According to initial failure site, the locoregional recurrence rate was 36.8%, and that for para-aortic lymph node metastasis and distant metastasis was 31.6%. The failure pattern was similar between the irradiation only group and the group with combined radiation and TAI. The incidence of intestinal complications of grades 1 and 2 was 20%. Irradiation combined with TAI did not increase the incidence of complications. (author)

  2. Cervical adenocarcinoma

    International Nuclear Information System (INIS)

    Glandular neoplasms of the uterine cervix represent a small but important group of cervical carcinomas. Included in the present study were 68 cases of primary adenocarcinomas of the uterine cervix seen from 1972 to 1986 in our Radiation Oncology Center. The complete data set for all patients was analyzed with regard to symptoms, histologic patterns, diagnostic procedures, treatment methods, and prognosis. The authors stress the importance of establishing the primary origin of the lesion in the cervix and of completely investigating patients with an abnormal bleeding pattern, even those with an apparently normal exocervix

  3. Changes in tumor oxygen tension during radiotherapy of uterine cervical cancer: relationships to changes in vascular density, cell density, and frequency of mitosis and apoptosis

    International Nuclear Information System (INIS)

    Purpose: Changes in oxygen tension (pO2) during the early phase of fractionated radiotherapy were studied in 22 patients with uterine cervical cancer. The aims were to investigate (a) whether possible changes in pO2 differed among and within tumors and (b) whether the changes could be attributed to changes in vascular density, cell density, and frequency of mitosis and apoptosis. Methods and Materials: The pO2 was measured polarographically in four regions of the tumors before treatment and after 2 weeks of radiotherapy. The vascular density, cell density, and frequency of mitosis and apoptosis were determined from biopsies taken from the tumor regions after each pO2 measurement. Results: The changes in pO2 during therapy differed among the tumors and were correlated to pO2 before treatment (p 2 and vice versa. The tumors with increased pO2 (n = 10) had a large decrease in cell density and a significant increase in apoptotic frequency. In contrast, the tumors with decreased pO2 (n = 10) had a smaller decrease in cell density (p = 0.014) and no significant increase in apoptotic frequency. Vascular density and mitotic frequency showed no change during therapy; however, vascular damage other than decreased vascular denr damage other than decreased vascular density was observed. Conclusion: These results indicate that the oxygenation of cervix tumors generally changes during the early phase of radiotherapy. The change depends on the balance between the factor leading to an increase and that leading to a decrease in oxygenation; i.e., decreased cell density and vascular damage, respectively. Increased apoptotic frequency may contribute to a large decrease in cell density and hence increased oxygenation during therapy

  4. Ganglio centinela para estadios tempranos en cáncer de cuello uterino / Sentinel lymph node detection in early uterine cervical cancer

    Scientific Electronic Library Online (English)

    Henry, Valdivia; Rossana, Morales; Luis, Taxa; Manuel, Álvarez; Carlos, Santos; Albert, Zevallos; Carlos, Velarde; Marco, Sánchez; Aldo, López; Absalón, Montoya.

    Full Text Available Objetivo: Determinar la factibilidad y seguridad del ganglio centinela (GC) con el uso combinado del mapeo linfático con Tc 99 y la inyección de colorante azul (patent blue) en pacientes con cáncer de cérvix temprano sometidas a histerectomía radical con linfadenectomía pélvica bilateral. Diseño: Es [...] tudio prospectivo. Institución: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú. Participantes: Pacientes con cáncer temprano de cuello uterino. Intervenciones: Entre diciembre de 2003 y diciembre de 2006, 66 pacientes con cáncer temprano de cuello estadios IA2 (n=2), IB1 (n=63) y IIA (n=1) fueron sometidas a detección del ganglio linfático centinela con linfoscintigrafía el día previo a la operación y mapeo linfático intraoperatorio con colorante azul y sonda detectora de radiación gama. El tratamiento quirúrgico se completó con la realización de la histerectomía radical y linfadenectomía pélvica bilateral, por laparotomía. Principales medidas de resultados: Detección de ganglios centinelas. Resultados: En las 66 pacientes estudiadas se detectó 136 ganglios centinelas, con un promedio de 2,06 por paciente. Se utilizó el método combinado (Tc 99 y patent blue). La localización más frecuente fue la región obturatriz con un 69,9% (n=95). Se halló metástasis en los ganglios pélvicos en 11 pacientes, que fueron correctamente localizadas en el ganglio centinela con una sensibilidad de 100%. Cuando el ganglio centinela fue negativo, no se encontró metástasis en los ganglios no centinela (VPN 100%). Conclusiones: La identificación del ganglio centinela con tecnecio-99 combinado con la inyección de colorante azul es factible y mostró un valor predictivo negativo de 100%. Abstract in english Objective: To determine sentinel node (SN) detection feasibility and safety by using lymphatic mapping with 99m Tc Dextrán and injection of blue dye (patent blue) in patients with early cervical cancer undergoing radical hysterectomy with bilateral pelvic lymphadenectomy. Design: Prospective study. [...] Setting: Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru. Participants: Patients with early cervical cancer. Interventions: Between December 2003 and December 2006, 66 patients with early cervical cancer stages IA2 (n = 2), IB1 (n = 63) and IIA (n = 1) underwent sentinel lymph node detection with lymphoscintigraphy the day before operation and intraoperative lymphatic mapping with blue dye and gamma radiation detection probe. Surgical treatment was completed with radical hysterectomy and bilateral pelvic lymphadenectomy by laparotomy. Main outcome measures: Sentinel node detection. Results: One hundred and thirty-six sentinel nodes were detected in all 66 patients, average 2.06 per patient, by using the combined method 99m Tc dextrán and patent blue. Most common location was the obturator region in 69.9% of cases (n = 95). Pelvic lymph node metastases were found by the sentinel node in 11 patients (sensitivity of 100%). In negative sentinel node cases (55 patients) no metastases were encountered (negative predictive value, NPV = 100%). Conclusions: Sentinel node identification using 99m technetium Dextrán and blue dye injection is feasible and had a negative predictive value of 100%.

  5. Critérios de positividade para cervicografia digital: melhorando a sensibilidade do diagnóstico do câncer cervical Digital cervicography criteria: improving sensitivity in uterine cervical cancer diagnosis

    Directory of Open Access Journals (Sweden)

    Eugênio Santana Franco

    2008-11-01

    Full Text Available O objetivo deste trabalho foi validar critérios de positividade para cervicografia digital. Estudo realizado com 300 mulheres submetidas a protocolo clínico composto por exame citológico, uma avaliação por meio de cervicografia digital sem ampliação de imagem (Avaliação 1, e outra avaliação também usando cervicografia digital mas com ampliação adicional de imagem e os critérios de positividade propostos neste estudo (Avaliação 2. A idade média das mulheres foi de 27,6 anos. Os critérios de positividade para cervicografia digital foram identificados em 111 casos (100% dos testes positivos para lesões precursoras do câncer do colo uterino e em 8 casos (2,6% considerados falso-positivos. As avaliações 1 e 2 classificaram os exames como positivos (163; 54,3% e suspeitos (146; 48,6%, respectivamente. Os resultados revelam que a cervicografia digital foi mais sensível (99,1% e a citologia mais específica (100%. O desempenho alcançado pela cervicografia digital, quando aplicado os critérios de positividade, alcançou sensibilidade 4,5 vezes superior ao desempenho da citologia oncológica, além do baixo custo, sugerindo ser uma técnica factível.This study aimed to validate the scoring criteria for digital cervicography. The study enrolled 300 women submitted to a clinical protocol using cytological examination alone, digital cervicography without image magnification (Evaluation 1, and digital cervicography plus additional image magnification and considering the positive criteria (Evaluation 2. Women's mean age was 27.6 years. Positive criteria for digital cervicography were identified in 111 positive cases with pre-cancerous cervical lesions (100% and in 8 cases classified as false positives (2.6%. Evaluations 1 and 2 classified the tests as positive (163; 54.3% and suspected (146; 48.6%, respectively. According to the findings, digital cervicography was more sensitive (99.1% and cytology more specific (100%. Digital cervicography sensitivity increased by 4.5 times when the positive criteria were applied as compared to cytology alone, besides involving low cost, thus suggesting that it is a viable technique.

  6. Radioterapia: percepção de mulheres com câncer cérvico-uterino / Radiotherapy: perception of women with uterine-cervical cancer / Radioterapia: percepción de mujeres con cáncer cérvico-uterino

    Scientific Electronic Library Online (English)

    Lúcia Helena Rios Barbosa de, Almeida; Yarla Brena Araújo de Sousa, Pereira; Thais Alexandre de, Oliveira.

    2008-08-01

    Full Text Available Realizou-se um estudo qualitaitvo com objetivo de conhecer a percepção das mulheres com câncer cérvico-uterino sobre a radioterapia, descrevendo as alterações físicas e cotidianas sofridas e evidenciando meios de enfrentamento e expectativas em relação ao tratamento. Foram entrevistadas 20 mulheres [...] em um hospital especializado, localizado na cidade de Teresina-PI. Os resultados mostraram que elas percebem a radioterapia como um bom tratamento, apesar do medo diante do desconhecido e das limitações no cotidiano, devido aos efeitos colaterais, que são enfrentados com suporte na religiosidade e no âmbito sócio-familiar, aumentando a expectativa de cura. Revelou-se a importância da orientação a essas mulheres pela equipe multiprofissional, especialmente o Enfermeiro, em todas as fases do tratamento. Abstract in spanish Se realizó un estudio con abordaje cualitativo objetivando conocer la percepción de las mujeres con cáncer cérvico-uterino sobre la radioterapia, describiendo las alteraciones físicas y cotidianas sufridas y evidenciando el medio utilizado para que enfrenten esas adversidades y sus expectativas con [...] relación al tratamiento. Fueron entrevistadas 20 mujeres en un hospital especializado, localizado en la ciudad de Teresina-PI. Los resultados mostraron que ellas perciben la radioterapia como un buen tratamiento, a pesar del miedo delante de lo desconocido y de las limitaciones en el cotidiano, debido a los efectos colaterales, que son enfrentados con base en la religiosidad y en el ámbito socio-familiar, aumentando la expectativa de cura. Se reveló la importancia de la orientación a esas mujeres por el equipo multiprofesional, especialmente el Enfermero, en todas las fases del tratamiento. Abstract in english This is a qualitiative study that aimed to know the perception of women with uterine-cervical cancer on the radiotherapy, describing the physical and daily alterations they suffered and evidencing the their coping to face these adversities and their expectations about the treatment. 20 women in a sp [...] ecialized hospital had been interviewed, located in the city of Teresina-PI. The results showed that they perceive the radiotherapy as a good treatment, although the fear ahead of the stranger and the limitations in the daily one, had to the side-effects, that are faced with support in the religious and the social-familiar scope, increasing the cure expectation. The importance of the orientation to these women for the multiprofessional team showed, especially the Nurse, in all the phases of the treatment.

  7. Optimum radiotherapy schedule for uterine cervical cancer based-on the detailed information of dose fractionation and radiotherapy technique

    International Nuclear Information System (INIS)

    The best dose-fractionation regimen of the definitive radiotherapy for cervix cancer remains to be clearly determined. It seems to be partially attributed to the complexity of the affecting factors and the lack of detailed information on external and intra-cavitary fractionation. To find optimal practice guidelines, our experiences of the combination of external beam radiotherapy (EBRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT) were reviewed with detailed information of the various treatment parameters obtained from a large cohort of women treated homogeneously at a single institute. The subjects were 743 cervical cancer patients (Stage IB 198, IIA 77, IIB 364, IIIA 7, IIIB 89 and IVA 8) treated by radiotherapy alone, between 1990 and 1996. A total external beam radiotherapy (EBRT) dose of 23.4 ? 59.4 Gy (Median 45.0) was delivered to the whole pelvis. High-dose-rate intracavitary brachytherapy (HDR-ICBT) was also performed using various fractionation schemes. A Midline block (MLB) was initiated after the delivery of 14.4? 43.2 Gy (Median 36.0) of EBRT in 495 patients, while in the other 248 patients EBRT could not be used due to slow tumor regression or the huge initial bulk of tumor. The point A, actual bladder and rectal doses were individually assessed in all patients. The biologically effective dose (BED) to the tumor (? / ? = 10) and late-responding tissues (? /? = 3) for both EBRT and HDR-ICBT were calculated. The total BED values to poilated. The total BED values to point A, the actual bladder and rectal reference points were the summation of the EBRT and HDR-ICBT. In addition to all the details on dose-fractionation, the other factors (i.e. the overall treatment time, physicians preference) that can affect the schedule of the definitive radiotherapy were also thoroughly analyzed. The association between MD-BED Gy3 and the risk of complication was assessed using serial multiple logistic regressions models. The associations between R-BED Gy3 and rectal complications and between V-BED Gy3 and bladder complications were assessed using multiple logistic regression models after adjustment for age, stage, tumor size and treatment duration. Serial Coxs proportional hazard regression models were used to estimate the relative risks of recurrence due to MD-BED Gy10 and the treatment duration. The overall complication rate for RTOG Grades 1 ? 4 toxicities was 33.1%. The 5-year actuarial pelvic control rate for all 743 patients was 83%. The midline cumulative BED dose, which is the sum of external midline BED and HDR-ICBT point A BED, ranged from 62.0 to 121.9 Gy10 (median 93.0) for tumors and from 93.6 to 187.3 Gy3 (median 137.6) for late responding tissues. The median cumulative values of actual rectal (R-BED Gy3) and bladder point BED (V-BED Gy3) were 118.7 Gy3 (range 48.8 ? 265.2) and 126.1 Gy3 (range: 54.9? 267.5), respectively. MD-BED Gy3 showed a good correlation with rectal (? =0.003), but not with bladder complications (? = 0.095), R-BED Gy3 had a very strong association (? = 3, B-BED Gy3 also showed significance in the prediction of bladder complications in a trend test (? = 0.0298). No statistically significant dose-response relationship for pelvic control was observed. The Sandwich and Continuous techniques, which differ according to when the ICR was inserted during the EBRT and due to the physicians preference, showed no differences in the local control and complication rates; there were also no differences in the 3 vs. 5 Gy fraction size of HDR-ICBT. The main reasons optimal dose-fractionation guidelines are not easily established is due to the absence of a dose-response relationship for tumor control as a result of the high-dose gradient of HDR-ICBT, individual differences in tumor responses to radiation therapy and the complexity of affecting factors. Therefore, in our opinion, there is a necessity for individualized tailored therapy, along with general guidelines, in the definitive radiation treatment for cervix cancer. This study also demonstrated the strong predictive valu

  8. Optimum radiotherapy schedule for uterine cervical cancer based-on the detailed information of dose fractionation and radiotherapy technique

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jae Ho; Kim, Hyun Chang; Suh, Chang Ok [Yonsei University Medical School, Seoul (Korea, Republic of)] (and others)

    2005-09-15

    The best dose-fractionation regimen of the definitive radiotherapy for cervix cancer remains to be clearly determined. It seems to be partially attributed to the complexity of the affecting factors and the lack of detailed information on external and intra-cavitary fractionation. To find optimal practice guidelines, our experiences of the combination of external beam radiotherapy (EBRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT) were reviewed with detailed information of the various treatment parameters obtained from a large cohort of women treated homogeneously at a single institute. The subjects were 743 cervical cancer patients (Stage IB 198, IIA 77, IIB 364, IIIA 7, IIIB 89 and IVA 8) treated by radiotherapy alone, between 1990 and 1996. A total external beam radiotherapy (EBRT) dose of 23.4 {approx} 59.4 Gy (Median 45.0) was delivered to the whole pelvis. High-dose-rate intracavitary brachytherapy (HDR-ICBT) was also performed using various fractionation schemes. A Midline block (MLB) was initiated after the delivery of 14.4{approx} 43.2 Gy (Median 36.0) of EBRT in 495 patients, while in the other 248 patients EBRT could not be used due to slow tumor regression or the huge initial bulk of tumor. The point A, actual bladder and rectal doses were individually assessed in all patients. The biologically effective dose (BED) to the tumor ({alpha} / {beta} = 10) and late-responding tissues ({alpha} /{beta} = 3) for both EBRT and HDR-ICBT were calculated. The total BED values to point A, the actual bladder and rectal reference points were the summation of the EBRT and HDR-ICBT. In addition to all the details on dose-fractionation, the other factors (i.e. the overall treatment time, physicians preference) that can affect the schedule of the definitive radiotherapy were also thoroughly analyzed. The association between MD-BED Gy{sub 3} and the risk of complication was assessed using serial multiple logistic regressions models. The associations between R-BED Gy{sub 3} and rectal complications and between V-BED Gy{sub 3} and bladder complications were assessed using multiple logistic regression models after adjustment for age, stage, tumor size and treatment duration. Serial Coxs proportional hazard regression models were used to estimate the relative risks of recurrence due to MD-BED Gy{sub 10} and the treatment duration. The overall complication rate for RTOG Grades 1 {approx} 4 toxicities was 33.1%. The 5-year actuarial pelvic control rate for all 743 patients was 83%. The midline cumulative BED dose, which is the sum of external midline BED and HDR-ICBT point A BED, ranged from 62.0 to 121.9 Gy{sub 10} (median 93.0) for tumors and from 93.6 to 187.3 Gy{sub 3} (median 137.6) for late responding tissues. The median cumulative values of actual rectal (R-BED Gy{sub 3}) and bladder point BED (V-BED Gy{sub 3}) were 118.7 Gy{sub 3} (range 48.8 {approx} 265.2) and 126.1 Gy{sub 3} (range: 54.9{approx} 267.5), respectively. MD-BED Gy{sub 3} showed a good correlation with rectal ({rho} =0.003), but not with bladder complications ({rho} = 0.095), R-BED Gy{sub 3} had a very strong association ({rho} = <0.0001), and was more predictive of rectal complications than A-BED Gy{sub 3}, B-BED Gy{sub 3} also showed significance in the prediction of bladder complications in a trend test ({rho} = 0.0298). No statistically significant dose-response relationship for pelvic control was observed. The Sandwich and Continuous techniques, which differ according to when the ICR was inserted during the EBRT and due to the physicians preference, showed no differences in the local control and complication rates; there were also no differences in the 3 vs. 5 Gy fraction size of HDR-ICBT. The main reasons optimal dose-fractionation guidelines are not easily established is due to the absence of a dose-response relationship for tumor control as a result of the high-dose gradient of HDR-ICBT, individual differences in tumor responses to radiation therapy and the complexity of affecting factors. Therefore, in our opinion, there is a necessity f

  9. A percepção da mulher sobre o exame preventivo do câncer cérvico-uterino: estudo de caso Women's perceptions of preventive examinations for cervical-uterine cancer: a case study

    Directory of Open Access Journals (Sweden)

    Lucélia Maria Duavy

    2007-06-01

    Full Text Available O câncer cérvico-uterino é uma das doenças crônico-degenerativas mais temidas, em razão do seu alto grau de letalidade e morbidade. Nesse sentido, realizamos um estudo para descrever a percepção das mulheres ante o exame de prevenção de câncer cérvico-uterino. Optamos por um estudo de caso tendo a observação e a entrevista semi-estruturada como técnicas de coleta das informações. Foram entrevistadas vinte e quatro mulheres, entre 18 e 60 anos, que buscaram o serviço de prevenção em uma unidade básica de saúde de Fortaleza-CE, entre abril e agosto de 2004. O estudo revelou que a mulher geralmente só procura fazer o exame de prevenção quando surgem sintomas, por ter vivenciado este exame com apreensão e medo pela possibilidade de um diagnóstico positivo de um câncer cérvico-uterino; sente-se constrangida em expor seu corpo e tê-lo examinado, sobretudo, quando o profissional de saúde é do sexo masculino; não tem conhecimento do corpo e tampouco de sua sexualidade. Esse resultado aponta para a necessidade de o profissional de saúde desenvolver atividades educativas junto às mulheres, no sentido de melhorar a relação profissional de saúdeusuária e, conseqüentemente, diminuir a incidência deste tipo de câncer, pela maior freqüência aos exames de prevenção.Cervical-uterine cancer is among the most feared chronic degenerative diseases, due its high mortality and morbidity rates. This study describes women's feelings before a preventive examination for cervical-uterine cancer, through a case study based on observations and semi-structured interviews as data collection techniques. A total of 24 women were interviewed, between eighteen and sixty years old, who attended the cancer prevention unit at a basic healthcare clinic in Fortaleza, Ceará State between April and August 2004. This study shows that women generally request these preventive examinations only when symptoms appear. They view this procedure with apprehension and fear, due to the possibility of a positive diagnosis of cervical-uterine cancer; they feel embarrassed at exposing their bodies for examination, particularly by male physicians; and they are poorly informed about their own bodies and even their own sexuality. These findings highlight the need for healthcare practitioners to conduct educational activities for women, in order to enhance professional relationships between healthcare providers and users, helping lower the rate of this type of cancer through more frequent preventive examinations.

  10. Uterine Fibroids

    Science.gov (United States)

    ... Content What are uterine fibroids? Uterine fibroids are growths made of smooth muscle cells and other tissue that develop within the ... Haneke, K., Vahdat, H. L., et al. (2008). Growth of uterine leiomyomata among premenopausal black and white women. Proceedings of the National Academy of Sciences of ...

  11. Extreme cervical elongation

    OpenAIRE

    Pb, Hiremath; Nidhi Bansal; Reshma Hiremath

    2014-01-01

    Uterine prolapse is a condition which has commonly affected women of all times. The problem of genital prolapse and its remedies is described in the oldest medical literature, the Egyptian Papyri. The normal length of the cervix is about 2.5 cm. The vaginal and supravaginal parts are of equal length. The elongation may affect either part of the cervix. The length of the uterocervical canal is measured by introduction of the uterine sound. Cervical elongation plays an important role in decidin...

  12. Micronúcleos em células do colo uterino em mulheres HIV+ segundo sua condição de imunidade / Micronuclei in uterine cervical cells of women HIV+ according to immunocompetence markers

    Scientific Electronic Library Online (English)

    Camila Figueira, Mendes; Gildo, Gardinalli Filho; Renato Marinho, Furoni; Luís Vicente Vélez, Miranda; Júlio, Boschini Filho; Luiz Ferraz De, Sampaio Neto.

    2011-10-01

    Full Text Available OBJETIVO: investigar a micronucleação (MN) em células esfoliadas do colo uterino de mulheres HIV+ observando as condições de imunidade aferidas pelos níveis de linfócitos CD4+ e da carga viral para o HIV (CV). MÉTODOS: foram obtidas coletas citológicas da junção escamocolunar de 23 pacientes HIV+ de [...] Ambulatório de DST/AIDS. O grupo controle foi composto por mulheres assintomáticas do Ambulatório de Prevenção de Câncer Ginecológico do mesmo serviço. O material foi submetido a processamento citológico para leitura em microscopia de luz, com objetiva de imersão em 2.000 células por paciente. Para avaliação da condição imunitária das pacientes HIV+ investigamos os níveis de linfócitos CD4+ e CV. A análise estatística dos resultados se fez com os testes do ?2 e Kolmogorov-Smirnov. RESULTADOS: vinte e três pacientes compuseram o grupo de mulheres HIV+ e 19 formaram o grupo controle. Em todas as pacientes HIV+ e em 84,2% do grupo controle detectamos MN. Dezessete pacientes HIV+ (73,9%) tiveram mais de 7 MN. No grupo controle tivemos apenas 1 caso (5,2%) com mais de 7 MN. Houve tendência na associação de maiores quantidades de MN em mulheres com baixos níveis de linfócitos CD4+ e maiores níveis de CV, sem caracterizar correlação estatística. CONCLUSÕES: pacientes HIV+ em fase de AIDS têm maior ocorrência de MN que o grupo controle e, também, a frequência com que são detectados MN parece estar associada a piores condições clínicas da imunossupressão. Abstract in english PURPOSE: to investigate the micronucleation (MN) of exfoliated cells from the uterine cervix of HIV+ women according to immunocompetence status. We investigated the clinical conditions of immunocompetence by analyzing the levels of CD4+ lymphocytes and viral count for HIV (VC). METHODS: biological m [...] aterial was collected from 23 HIV+ patients whose cervical oncologic cytology results were negative. They were patients from the STD/AIDS-FCMS-PUCSP who underwent a cytobrush collection in the squamous columnar junction. Similar material was obtained from 19 healthy control women. The material, about 2000 cells per patient, was processed for cytology using light microscopy and an immersion objective. To analyze the immunological status of HIV+ patients we used CD4+ count and VC. Statistical analysis was performed using the ?2 and Kolmorogov-Smirnov tests. RESULTS: twenty-three pacients composed the group of HIV+ women and 19 composed the control group. We found micronuclei (MN) in all HIV+ patients and in 84.2% of the control group. In 17 73.9% of the HIV+ patients and in 5.2% of the control group we found more than 7 MN cells. MN tended to occur more among women with poorer immunological status in the HIV+ group. CONCLUSIONS: HIV+ patients in the AIDS phase have a higher prevalence of micronucleated cells, as opposed to a control group. Also, the frequency of MN was associated with worse conditions of immunosuppression.

  13. Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile / Detection and genotyping of human papillomavirus in biopsies of uterine cervical adenocarcinoma

    Scientific Electronic Library Online (English)

    Priscilla, Brebi M; Carmen Gloria, Ili G; Jaime, López M; Patricia, García M; Angélica, Melo A; Sonia, Montenegro H; Pamela, Leal R; Pablo, Guzmán G; Juan Carlos, Roa S.

    2009-03-01

    Full Text Available [...] Abstract in english Background: The genotyping of Human Papillomavirus (HPV) will improve knowledge about the local epidemiological association of this virus with adenocarcinoma. Aim: To determine the frequency of HPV genotypes in biopsies of women with uterine cervical adenocarcinoma in a geographic region of Chile. M [...] aterials and Methods: Forty-one cervical biopsies with a pathological diagnosis of adenocarcinoma, corresponding to all women diagnosed with this cancer between 2002 and 2004, were analyzed. Viral gene Ll was amplified by PCRfor viral detection. HPV genotyping was carried out by a Reverse Line Blot technique. Results: Seventy one percent of biopsies were positive for HPV. The most common genotypes found were HPV 16 (61%), followed by HPV 18 (19.5%). Eighty seven percent of biopsies had a single HPV infection. Three patients had a multiple HPV infection. All of the latter were infected by HPV 16, associated with other three viral genotypes (45, 52 and 66). No low-risk HPV genotypes were found. Conclusions: In this sample of biopsies, there was a high prevelence of HPV 16 and a low prevalence of HPV 18, which historically has been related to adenocarcinoma. The genotypes found correspond to those described in South America.

  14. Giant prolactinoma presenting as a skull base tumor with erosion of the cervical vertebrae: pronounced responsiveness to dopamine agonist treatment.

    Science.gov (United States)

    Bjerg, Mia L; Rosendal, Frederikke; Nielsen, Edith; Ulhøi, Benedikte Palm; Jørgensen, Jens O L

    2014-08-27

    Giant prolactinomas are rare and usually associated with symptoms attributable to hypopituitarism and compression of juxtasellar structures such as the cranial nerves of the cavernous sinus and the optic chiasm. Occasionally, they masquerade as skull base tumors with atypical symptoms. We describe a patient who presented with a low-energy trauma in the neck region that led to the initial diagnosis of a large skull base tumor eroding the cervical vertebrae. After stabilizing surgery, the patient responded to dopamine agonist therapy with normalization of serum prolactin levels and pronounced reduction in tumor volume. PMID:25162753

  15. Possible evidence that dehydroepiandrosterone sulfate (DHA-S) stimulates cervical ripening by a membrane-mediated process: Specific binding-sites in plasma membrane from human uterine cervix

    International Nuclear Information System (INIS)

    Fetal adrenal steroid, dehydroepiandrosterone sulfate (DHA-S) is well known to promote cervical ripening in late pregnancy. The presence of sites specifically binding the DHA-S in plasma membrane was studied in human cervical fibroblasts prepared from pregnant uterus. The fibroblasts were incubated with 3H DHA-S and then fractionated into plasma membranes, cytosol, nuclei, and other organella debris. The specific activity of 3H-count in the plasma membrane fraction was enriched ? 7-fold compared with the whole homogenate. When the isolated plasma membrane preparations from the fibroblasts were exposed to 3H DHA-S, the binding showed saturation kinetics; an apparent equilibrium dissociation constant (Kd) of 12 nM, and the binding capacity (Bmax) of 1.25 pmol/mg protein. The present results suggest that DHA is bound to and recognized by components in plasma membrane, and may exert its action on cervical ripening through the membrane-mediated processes

  16. Cervical syphilitic lesions mimicking cervical cancer: a rare case report

    Directory of Open Access Journals (Sweden)

    Xiaoqing Zhu

    2015-02-01

    Full Text Available A woman presented to the hospital due to postcoital vaginal bleeding. The patient was initially diagnosed with cervical carcinoma by clinicians at a local hospital. However, a biopsy of the cervical lesions revealed chronic inflammation and erosion of the cervical mucosa, and the rapid plasma reagin ratio titer was 1:256. The patient was eventually diagnosed with syphilitic cervicitis and treated with minocycline 0.1 g twice a day. The patient was cured with this treatment.

  17. Avaliação do Comprimento do Colo Uterino nas Posições Ortostática e Decúbito Horizontal nas Gestações Gemelares Uterine Cervical Length Evaluation in the Standing and Recumbent Positions in Twin Pregnancies

    Directory of Open Access Journals (Sweden)

    Tatiana Bernáth

    2002-05-01

    Full Text Available Objetivo: avaliação ultra-sonográfica e comparação da medida do comprimento do colo uterino nas gestações gemelares com as pacientes nas posições de decúbito dorsal horizontal (DDH e ortostática. Métodos: 50 gestações gemelares foram submetidas a avaliações ultra-sonográficas para medida do comprimento do colo uterino no período de maio de 1999 a dezembro de 2000. Os exames foram realizados pela via transvaginal com periodicidade de 4 semanas totalizando 136 avaliações. A cérvice uterina foi avaliada, segundo técnica normatizada, com a paciente nas posições de decúbito dorsal horizontal e ortostática. Resultados: as medidas do colo uterino nas posições DDH e ortostática na primeira avaliação apresentaram correlação inversa com a idade gestacional (DDH: r=-0,60; pPurpose: to compare cervical length measurements in twin pregnancies obtained by transvaginal ultrasound examination in the recumbent and standing positions. Methods: fifty twin pregnancies underwent transvaginal ultrasound examinations to measure the cervical length with the women in recumbent and standing positions. The study was carried out between May 1999 and December 2000. The scans were repeated every 4 weeks and the total number of evaluations was 136. Two groups were analyzed: one included only the first ultrasound examinations carried out in each woman and the second group included all evaluations. Results: in the first group, cervical length measurements in the standing and recumbent positions correlated inversely with the gestational age (recumbent: r=-0.60; p<0.001; standing: r=-0.46; p=0.008. The mean measure in the recumbent position was 35.2 mm (SD=9.9 mm and 33.4 mm (SD=9.5 mm in the standing position. When the difference between the measure obtained in the standing and recumbent positions was expressed as percentage of the measure in the recumbent position, there was no significant association with gestational age (p=0.07. When all evaluations were considered, there was a significant association between cervical length in the recumbent and standing positions (r=0.79; p<0.001. The measures in recumbent and standing positions were inversely correlated with gestational age (recumbent: p<0.0001; standing: p<0.0001. The mean cervical length in the recumbent position was 33.5 mm (SD=10.8 mm and 31.8 mm (SD=9.6 mm in the standing position. There was no significant association between cervical length difference expressed as percentage of the measure in the recumbent position and gestation. Conclusion: cervical length measure obtained with the patients in the recumbent and standing positions provided similar information.

  18. Magnetic resonance imaging of cancer of uterine cervix and body. Preliminary study in 9 cases of body cancer and 20 of cervical cancer

    International Nuclear Information System (INIS)

    We studied nine cases of endometrial carcinoma and twenty of cervix carcinoma. Correlation with histology is made after curietherapy in 8 cases of endometrial carcinoma. Tumor is not always seen and particularly when there is no mass effect on macroscopic examination. Myometral invasion is not seen with accuracy: the interruption of junctional zone is not a good sign. The cervix tumors are well seen on T2 sequences before any treatment. There extra uterine extension is difficult to appreciate. The best results of RMI were in the follow-up after radiotherapy. Therefore it appears actually to us the best indication of RMI

  19. Preliminary Experience with Locoregional Intraarterial Chemotherapy of Uterine Cervical or Endometrial Cancer Using the Peripheral Implantable Port System (PIPSTM): A Feasibility Study

    International Nuclear Information System (INIS)

    The purpose of this study was to assess the suitability of a percutaneously implantable catheter port system (PIPS)for repeated intraarterial locoregional chemotherapy (ILC) for cervical and endometrial carcinoma. In 30 patients with advanced, recurrent, or high-risk cervical (n 23) or endometrial(n = 7) carcinoma, PIPS for ILC was implanted via a femoral access, the catheter localized in the infrarenal abdominal aorta. Chemotherapy was performed adjuvantly after surgery(n = 14) or neo-adjuvantly to enable surgery, or for palliation (n = 16). Port implantation, catheter placement, and repeated port puncture was uneventful in all patients.Complications included catheter dislocation (n = 1),catheter thrombosis (n = 2), subcutaneous infection(n = 1), port-bed skin atrophy (n = 1),requiring port explantation in 3 patients. At 2 years follow-up,complete remission was observed in 7/14 patients with adjuvant chemotherapy, partial remission in 3/14. Successful down-staging could be achieved in 4/8 patients with neo-adjuvant chemotherapy. The PIPS is suitable for repeated ILC which may be a valuable method for pre- and post-surgical therapy of advanced or high-risk cervical and endometrial cancer, for adjuvant chemotherapy as well as neo-adjuvantly for down-staging, or for palliation

  20. Avaliação do Comprimento do Colo Uterino nas Posições Ortostática e Decúbito Horizontal nas Gestações Gemelares / Uterine Cervical Length Evaluation in the Standing and Recumbent Positions in Twin Pregnancies

    Scientific Electronic Library Online (English)

    Tatiana, Bernáth; Maria de Lourdes, Brizot; Adolfo Wenjaw, Liao; Luciana, Cury; Jorge Demétrio, Banduki; Marcelo, Zugaib.

    2002-05-01

    Full Text Available Objetivo: avaliação ultra-sonográfica e comparação da medida do comprimento do colo uterino nas gestações gemelares com as pacientes nas posições de decúbito dorsal horizontal (DDH) e ortostática. Métodos: 50 gestações gemelares foram submetidas a avaliações ultra-sonográficas para medida do comprim [...] ento do colo uterino no período de maio de 1999 a dezembro de 2000. Os exames foram realizados pela via transvaginal com periodicidade de 4 semanas totalizando 136 avaliações. A cérvice uterina foi avaliada, segundo técnica normatizada, com a paciente nas posições de decúbito dorsal horizontal e ortostática. Resultados: as medidas do colo uterino nas posições DDH e ortostática na primeira avaliação apresentaram correlação inversa com a idade gestacional (DDH: r=-0,60; p Abstract in english Purpose: to compare cervical length measurements in twin pregnancies obtained by transvaginal ultrasound examination in the recumbent and standing positions. Methods: fifty twin pregnancies underwent transvaginal ultrasound examinations to measure the cervical length with the women in recumbent and [...] standing positions. The study was carried out between May 1999 and December 2000. The scans were repeated every 4 weeks and the total number of evaluations was 136. Two groups were analyzed: one included only the first ultrasound examinations carried out in each woman and the second group included all evaluations. Results: in the first group, cervical length measurements in the standing and recumbent positions correlated inversely with the gestational age (recumbent: r=-0.60; p

  1. Uterine Fibroids

    Science.gov (United States)

    Uterine fibroids are the most common benign tumors in women of childbearing age. Fibroids are made of muscle cells and other tissues ... of the uterus, or womb. The cause of fibroids is unknown. Risk factors include being African American ...

  2. Uterine Cancer

    Science.gov (United States)

    ... is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, the lining of the uterus. This type of cancer is sometimes called endometrial cancer. The symptoms of ...

  3. Uterine Fibroids Fact Sheet

    Science.gov (United States)

    ... Our ePublications > Uterine fibroids fact sheet ePublications Uterine fibroids fact sheet Print this fact sheet Uterine fibroids ... fibroids? More information on uterine fibroids What are fibroids? Fibroids are muscular tumors that grow in the ...

  4. Lesões precursoras do câncer cervicouterino: evolução histórica e subsídios para consulta de enfermagem ginecológica Lesiones precursoras del cáncer cervical-útero: evolución histórica consolidando la consulta de enfermería ginecológica Cervical-uterine cancer precursor lesions: historical evolution supporting the gynecological nursing consultation

    Directory of Open Access Journals (Sweden)

    Maria Cristina de Melo Pessanha Carvalho

    2010-09-01

    Full Text Available Estudo emergido de recorte de dissertação de mestrado, ilustrando a evolução histórica das lesões precursoras do câncer cervicouterino (LPCCU. Trata-se da história das LPCCU, delineando a relevância do conhecimento para prática do enfermeiro na área da saúde da mulher. O conceito de LPCCU inicia-se a partir do século XIX, dando início aos estudos das células alteradas. Objetivo: descrever as diversas fases da evolução histórica das alterações cervicais. Estudo qualitativo, descritivo-analítico, recorte temporal no período de 1940 a 2008. Dados levantados mediante bibliografia de fonte primária e recurso BIREME. Pontuaram-se as classificações que já existiram, destacando a Nomenclatura Brasileira, importante para corresponder às necessidades e o perfil da saúde das mulheres do Brasil. Este estudo é o ponto de partida para respaldar as práticas de consulta de enfermagem ginecológica com abordagens educativas, contemplando a população feminina em ações preventivas e incentivo ao tratamento.Estudio emergido de recorte de disertación de máster, ilustrando la evolución histórica de las lesiones precursoras del cáncer cervical-uterino (LPCCU. Se trata de la historia de las LPCCU, delineando la relevancia del conocimiento para la práctica del enfermero en cuidados en la salud de la mujer. El concepto de LPCCU se inicia a partir del siglo XIX, empezando los estudios de las células alteradas. Como objetivo: describir las diversas fases históricas de las alteraciones cervicales. Estudio cualitativo, descriptivo-analítico, recorte temporal en el período de 1940 hasta 2008. Datos acrecentados mediante bibliografía de fuente primaria y recurso BIREME. Se puntuó las diferentes clasificaciones que ya existieron, conde destaque para la nomenclatura brasileña, importante para corresponder a las necesidades y el perfil de la salud de las mujeres del Brasil. Esto estudio es el ponto de partida para respaldar las prácticas de consulta de enfermería ginecológica con abordajes educativas, contemplando la población femenina en acciones preventivas y incentivo al tratamiento.Study emerged from an article of the master degree that illustrates the phases of the historical evolution of the precursor lesions of the cervical-uterine cancer. Thus, it is a question of the history about, delineating the relevance of this knowledge for the nurse's practice in care in the woman's health. The precursor lesions concept of the cervical-uterine cancer, initiates itself from the XIX century, beginning with studies of the cells altered. It had as objective: describe the diverse historical phases of the cervical-uterine cancer. A qualitative, descriptive-analytical study, using time cutting in the period of 1940 to 2008. The data were raised by means of bibliographical reference as primary spring and about the resource BIREME, By means of this study was possible to score the different classifications that already existed, highlighting the Brazilian Nomenclature was important to correspond the needs and the profile of the health of the women of Brazil. This study is the starting point to support the gynecological nursing consultation practices with educational approaches, contemplating the female population in preventive actions and incentive to the treatment.

  5. In Search of Efficacy of Valethamte Bromide, a Cervical Dilator

    OpenAIRE

    Ashok, K. B.

    2011-01-01

    Background: Labour is a normal physiological process, progress of which depends upon the strength andfrequency of uterine contractions and simultaneous active cervical dilatation. But sometimes activecervical dilatation lags behind even though there is presence of uterine contraction and causes painabdomen, prolongation of labour which can hamper both maternal and foetal health. Hence comes theneed to use the cervical dilators to encourage the cervical dilatation to compete with the frequent ...

  6. Laparoscopia quirúrgica en cáncer de cuello uterino, en el Hospital IV Huancayo EsSalud / Surgical laparoscopy in uterine cervical cancer at EsSalud Huancayo Hospital

    Scientific Electronic Library Online (English)

    Ernesto, Molina-Loza; Carlos, Altez-Navarro; Gregorio, Ortiz-Lorenzo.

    Full Text Available Introducción: El cáncer de cérvix es la causa más frecuente de muerte en la sierra central peruana. El tratamiento quirúrgico (histerectomía total laparoscópica e histerectomía radical más linfadenectomía pélvica laparoscópica) es el recurso terapéutico mayormente curativo en los estadios iníciales [...] (Ia1, Ia2 y Ib1). Hace un año en el Servicio de Ginecología del Hospital IV Huancayo iniciamos el tratamiento quirúrgico laparoscópico en estos estadios. Objetivos: Revisar los resultados de histerectomía laparoscópica en cáncer microinvasivo de cuello uterino. Diseño: Estudio retrospectivo. Institución: Servicio de Ginecología, Hospital IV Huancayo, EsSalud, Junín, Perú. Pacientes: Doce mujeres sometidas a histerectomía laparoscópica por carcinoma microinvasivo de cérvix. Intervenciones: En seis mujeres con diagnóstico preoperatorio de cáncer de cérvix por conización cervical y estadio clínico Ia1 se les realizó histerectomía laparoscópica, con un tiempo operatorio de 59,16 minutos y tiempo de estancia hospitalaria de 4,1 días. A otras seis mujeres con estadio clínico Ia2-Ib1 se les realizó histerectomía radical más linfadenectomía pélvica laparoscópica, con un tiempo operatorio de 3 horas 58 minutos y tiempo de estancia hospitalaria de 10,1 días. Principales medidas de resultados: Curación clínica. Resultados: Todos los diagnósticos fueron confirmados con la pieza operatoria, y todas las pacientes están teóricamente curadas (márgenes libres, ganglios negativos); una paciente presentó complicaciones, requiriendo estancia prolongada (8,3%). Conclusiones: La histerectomía total laparoscópica y la histerectomía radical más linfadenectomía pélvica laparoscópica pueden ser realizadas de manera más rápida y radical con respecto a la histerectomía convencional por laparotomía. Ambas son intervenciones factibles y seguras, que pueden garantizar la curación en el carcinoma microinvasivo de cuello uterino. Abstract in english Introduction: Cervical cancer is the most common cause of death in Peruvian central highlands. Surgical treatment (hysterectomy and total laparoscopic radical hysterectomy plus pelvic lymphadenectomy) is the best therapeutic resource in the early cancer stage (IA1, IA2 and IB1). One year ago we star [...] ted laparoscopic surgical treatment in these stages at Hospital IV Huancayo Gynecology Department. Objectives: To review outcomes of laparoscopic hysterectomy for microinvasive cervical cancer. Design: Retrospective study. Setting: Gynecology Service, Hospital IV Huancayo, EsSalud, Junin, Peru. Patients: Twelve women subjected to laparoscopic hysterectomy for cervical microinvasive carcinoma. Interventions: Six women with preoperative diagnosis by cervical conization and clinical stage IA1 underwent laparoscopic hysterectomy with 59.16 minutes operative time and 4.1 days hospital stay. Other six women with clinical stage Ia2-Ib1 underwent laparoscopic radical hysterectomy plus pelvic lymphadenectomy with operative time 3 hours and 58 minutes, and hospital stay of 10.1 days. Main outcome measures: Clinical cancer cure. Results: All diagnoses were confirmed by the surgical specimen and all were theoretically cured (negative margins, negative lymph nodes); one patient had complications that required prolonged stay (8.3%). Conclusions: Total laparoscopic hysterectomy and laparoscopic radical hysterectomy plus pelvic lymphadenectomy can be performed faster and more radically compared with conventional laparotomy. Both are feasible and safe interventions that ensure cure in microinvasive cervical carcinoma.

  7. Can ABCF2 protein expression predict the prognosis of uterine cancer?

    OpenAIRE

    Nishimura, S.; Tsuda, H.; Miyagi, Y.; Hirasawa, A.; Suzuki, A.; Kataoka, F.; Nomura, H.; Chiyoda, T.; Banno, K.; Fujii, T.; Susumu, N.; Aoki, D.

    2008-01-01

    Uterine cervical and endometrial cancers are common malignant solid neoplasms for which there are no useful prognostic markers. In this study, we evaluate the relationship between ATP-binding cassette superfamily F2 (ABCF2) expression and clinical factors including clinical stage, histologic type, grade and prognosis in uterine cervical and endometrial cancer. Two hundred and sixty seven cervical and 103 endometrial cancers were studied. ATP-binding cassette superfamily F2 cytoplasmic express...

  8. A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy

    OpenAIRE

    Kim Tae Hyun; Kim Joo-Young; Sohn Dae Kyung; Kim Yeon-Joo; Lee Yoon-Seok; Moon Sung Ho; Kim Sang Soo; Kim Dae Yong

    2013-01-01

    Abstract Purpose We assessed the value of dose-volumetric parameters predicting rectosigmoid mucosal changes (RMC) and late rectosigmoid complications (LRC). Methods Between January 2004 and February 2006, 77 patients with stage IB-IIIB cervical cancer underwent external beam radiotherapy and computed tomography (CT)-based intracavitary irradiation. Total dose to the rectal point and several dose-volumetric parameters for rectosigmoid colon (D20cc, D15cc, D10cc, D5cc, D2cc, D1cc, and D0.1cc ,...

  9. Prevalence of micronuclei in exfoliated uterine cervical cells from patients with risk factors for cervical cancer / Prevalência de micronúcleos em células esfoliativas do colo uterino de pacientes com fatores de risco para o câncer de colo uterino

    Scientific Electronic Library Online (English)

    Lízia Maria Franco dos Reis, Campos; Francisca da Luz, Dias; Lusânia Maria Greggi, Antunes; Eddie Fernando Candido, Murta.

    2008-11-01

    Full Text Available CONTEXTO E OBJETIVO: O câncer do colo uterino é uma das mais freqüentes neoplasias na mulher. O exame de Papanicolaou é o método mais comum e econômico para rastreamento. As células esfoliativas epiteliais podem ser úteis para o monitoramento de pacientes expostas a fatores de risco para o câncer. O [...] objetivo foi analisar a prevalência de micronúcleos em células esfoliativas da mucosa cervical uterina e associar com fatores de risco para o câncer de colo uterino. TIPO DE ESTUDO E LOCAL: Estudo transversal analítico, no Instituto de Pesquisa em Oncologia (IPON). MÉTODOS: Células esfoliativas do colo uterino foram obtidas de 101 pacientes ambulatoriais entre setembro/2004 e novembro/2005. As células foram coletadas usando espátula de Ayre e transferidas para um tubo de ensaio com soro fisiológico 0,9% para o teste do micronúcleo. Informações obtidas das pacientes foram: idade, hábitos (fumo e número de parceiros sexuais), métodos contraceptivos, história de doença sexualmente transmissível e uso de terapia hormonal. Células foram analisadas com magnificação de 1000 X e os micronúcleos contados em 1.000 células epiteliais por paciente. RESULTADOS: A comparação do grupo de pacientes fumantes ativas (7,9 ± 7,8) e passivas (7,2 ± 10,6) versus não fumantes (3,7 ± 5,1); alcoolismo e não alcoolismo (7,8 ± 1,4 e 6,9 ± 10,1); citologia inflamatória e citologia normal (10,7 ± 10,5 e 1,3 ± 1,7); neoplasia intraepitelial cervical (NIC) I, II e III e a ausência de NIC, respectivamente, (4,3 ± 4,3; 10,6 ± 5,3; 22,7 ± 11,9 e 1.3 ± 1.4) mostrou maior prevalência de micronúcleos (P Abstract in english CONTEXT AND OBJECTIVE: Pap smears are the most common and inexpensive screening method for cervical cancer. We analyzed micronucleus prevalence in exfoliated cervical mucosa cells, to investigate associations between increased numbers of micronuclei and risk factors for cervical cancer. DESIGN AND S [...] ETTING: Analytical cross-sectional study, at Instituto de Pesquisa em Oncologia (IPON). METHODS: Exfoliated cervical cells were obtained from 101 patients between September 2004 and November 2005. Patients' ages, habits (passive or active smoking, alcoholism and numbers of sexual partners), age at first sexual intercourse, contraceptive methods used, histories of sexually transmitted diseases, use of hormone replacement therapy, numbers of pregnancies and abortions, inflammatory cytology and cervical intraepithelial neoplasia (CIN) were obtained. Cells were collected using Ayre spatulas, transferred to vials containing 0.9% saline solution for micronucleus tests and analyzed at 1000x magnification. The number of micronuclei in 1,000 epithelial cells per patient sample was counted. RESULTS: Comparisons between groups with active (7.9 ± 7.8) and passive (7.2 ± 10.6) smoking versus no smoking (3.7 ± 5.1); with/without alcoholism (7.8 ± 1.4 and 6.9 ± 10.1); with/without inflammatory cytology (10.7 ± 10.5 and 1.3 ± 1.7); and with CIN I, II and III and no CIN (respectively 4.3 ± 4.3, 10.6 ± 5.3, 22.7 ± 11.9 and 1.3 ± 1.4) found elevated micronucleus prevalence (P

  10. Antimicrobial factors in the cervical mucus plug

    DEFF Research Database (Denmark)

    Hein, Merete; Valore, Erika V

    2002-01-01

    The cervical mucus plug is positioned between the microbe-rich vagina and the normally sterile uterine cavity, which suggests a host defense function, but few relevant data are available. We analyzed the composition and antimicrobial activity of cervical mucus plugs.

  11. Insufficiency Fractures After Pelvic Radiation Therapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG)

    International Nuclear Information System (INIS)

    Purpose: To investigate pelvic insufficiency fractures (IF) after definitive pelvic radiation therapy for early-stage uterine cervical cancer, by analyzing subjects of a prospective, multi-institutional study. Materials and Methods: Between September 2004 and July 2007, 59 eligible patients were analyzed. The median age was 73 years (range, 37-84 years). The International Federation of Gynecologic Oncology and Obstetrics stages were Ib1 in 35, IIa in 12, and IIb in 12 patients. Patients were treated with the constant method, which consisted of whole-pelvic external-beam radiation therapy of 50 Gy/25 fractions and high-dose-rate intracavitary brachytherapy of 24 Gy/4 fractions without chemotherapy. After radiation therapy the patients were evaluated by both pelvic CT and pelvic MRI at 3, 6, 12, 18, and 24 months. Diagnosis of IF was made when the patients had both CT and MRI findings, neither recurrent tumor lesions nor traumatic histories. The CT findings of IF were defined as fracture lines or sclerotic linear changes in the bones, and MRI findings of IF were defined as signal intensity changes in the bones, both on T1- and T2-weighted images. Results: The median follow-up was 24 months. The 2-year pelvic IF cumulative occurrence rate was 36.9% (21 patients). Using Common Terminology Criteria for Adverse Events version 3.0, grade 1, 2, and 3 IF were seen in 12 (21%), 6 (10%), and 3 patients (5%), respectively. Sixteen patients had multiple fractures, so IF were idents had multiple fractures, so IF were identified at 44 sites. The pelvic IF were frequently seen at the sacroileal joints (32 sites, 72%). Nine patients complained of pain. All patients' pains were palliated by rest or non-narcotic analgesic drugs. Higher age (>70 years) and low body weight (<50 kg) were thought to be risk factors for pelvic IF (P=.007 and P=.013, Cox hazard test). Conclusions: Cervical cancer patients with higher age and low body weight may be at some risk for the development of pelvic IF after pelvic radiation therapy.

  12. Prospective Multi-Institutional Study of Definitive Radiotherapy With High-Dose-Rate Intracavitary Brachytherapy in Patients With Nonbulky (<4-cm) Stage I and II Uterine Cervical Cancer (JAROG0401/JROSG04-2)

    Energy Technology Data Exchange (ETDEWEB)

    Toita, Takafumi, E-mail: b983255@med.u-ryukyu.ac.jp [Department of Radiology, Graduate School of Medical Science, University of Ryukyus, Okinawa (Japan); Kato, Shingo [Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Niibe, Yuzuru [Department of Radiology, School of Medicine, Kitasato University, Sagamihara (Japan); Ohno, Tatsuya [Gunma University Heavy Ion Medical Center, Maebashi (Japan); Kazumoto, Tomoko [Department of Radiology, Saitama Cancer Center, Saitama (Japan); Kodaira, Takeshi [Department of Radiation Oncology, Aichi Cancer Center, Nagoya (Japan); Kataoka, Masaaki [Department of Radiology, National Shikoku Cancer Center, Ehime (Japan); Shikama, Naoto [Department of Radiation Oncology, Saku Central Hospital, Saku (Japan); Kenjo, Masahiro [Department of Radiation Oncology, Graduate School of Medical Science, Hiroshima University, Hiroshima (Japan); Tokumaru, Sunao [Department of Radiology, Saga University, Saga (Japan); Yamauchi, Chikako [Department of Radiation Oncology, Shiga Medical Center for Adults, Moriyama (Japan); Suzuki, Osamu [Department of Radiation Oncology, Osaka Medical Center for Cancer, Osaka (Japan); Sakurai, Hideyuki [Proton Medical Research Center and Tsukuba University, Tsukuba (Japan); Numasaki, Hodaka; Teshima, Teruki [Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Suita, Osaka (Japan); Oguchi, Masahiko [Department of Radiation Oncology, Cancer Institute Hospital, Tokyo (Japan); Kagami, Yoshikazu [Radiation Oncology Division, National Cancer Center Hospital, Tokyo (Japan); Nakano, Takashi [Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi (Japan); Hiraoka, Masahiro [Department of Radiation Oncology and Image-applied Therapy, Kyoto University, Graduate School of Medicine, Kyoto (Japan); Mitsuhashi, Norio [Department of Radiation Oncology, Tokyo Women' s Medical University, Tokyo (Japan)

    2012-01-01

    Purpose: To determine the efficacy of a definitive radiotherapy protocol using high-dose-rate intracavitary brachytherapy (HDR-ICBT) with a low cumulative dose schedule in nonbulky early-stage cervical cancer patients, we conducted a prospective multi-institutional study. Methods and Materials: Eligible patients had squamous cell carcinoma of the intact uterine cervix, Federation of Gynecologic Oncology and Obstetrics (FIGO) stages Ib1, IIa, and IIb, tumor size <40 mm in diameter (assessed by T2-weighted magnetic resonance imaging), and no pelvic/para-aortic lymphadenopathy. The treatment protocol consisted of whole-pelvis external beam radiotherapy (EBRT) of 20 Gy/10 fractions, pelvic EBRT with midline block of 30 Gy/15 fractions, and HDR-ICBT of 24 Gy/4 fractions (at point A). The cumulative biologically effective dose (BED) was 62 Gy{sub 10} ({alpha}/{beta} = 10) at point A. The primary endpoint was the 2-year pelvic disease progression-free (PDPF) rate. All patients received a radiotherapy quality assurance review. Results: Between September 2004 and July 2007, 60 eligible patients were enrolled. Thirty-six patients were assessed with FIGO stage Ib1; 12 patients with stage IIa; and 12 patients with stage IIb. Median tumor diameter was 28 mm (range, 6-39 mm). Median overall treatment time was 43 days. Median follow-up was 49 months (range, 7-72 months). Seven patients developed recurrences: 3 patients had pelvic recurrences (2 central, 1 nodal), and 4 patients had distant metastases. The 2-year PDPF was 96% (95% confidence interval [CI], 92%-100%). The 2-year disease-free and overall survival rates were 90% (95% CI, 82%-98%) and 95% (95% CI, 89%-100%), respectively. The 2-year late complication rates (according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer of Grade {>=}1) were 18% (95% CI, 8%-28%) for large intestine/rectum, 4% (95% CI, 0%-8%) for small intestine, and 0% for bladder. No Grade {>=}3 cases were observed for genitourinary/gastrointestinal late complications. Conclusions: These results suggest that definitive radiotherapy using HDR-ICBT with a low cumulative dose schedule (BED, 62 Gy{sub 10} at point A) can provide excellent local control without severe toxicity in nonbulky (<4-cm) early-stage cervical cancer.

  13. Extreme cervical elongation

    Directory of Open Access Journals (Sweden)

    Hiremath PB

    2014-06-01

    Full Text Available Uterine prolapse is a condition which has commonly affected women of all times. The problem of genital prolapse and its remedies is described in the oldest medical literature, the Egyptian Papyri. The normal length of the cervix is about 2.5 cm. The vaginal and supravaginal parts are of equal length. The elongation may affect either part of the cervix. The length of the uterocervical canal is measured by introduction of the uterine sound. Cervical elongation plays an important role in deciding the surgical treatment. We had a case of extreme cervical elongation and we faced difficulties during the surgery. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 777-779

  14. Radiation therapy of the uterine cancer

    International Nuclear Information System (INIS)

    Cervical and endometrial cancer of the uterus, and ovarian cancer are three major malignant diseases in gynecology in Japan. These diagnosis and therapy are almost established. In uterine cervical cancer, radiation therapy and surgery of these diseases are two main treatment methods, and both treatment results are almost the same. And radiation therapy is also used as postoperative treatment to patients with high risk factors. In endometrial cancer, surgery is main therapy. Radiation therapy is undergone only to medically inoperable cases preoperative radiation is widely carried out in Europe and America, but almost none in Japan. Postoperative irradiation is adapted to the cases with high risk factors. But recent advance of chemotherapy changes the importance of radiation therapy in such patients. I review the literatures of radiation therapy of uterine cervical cancer and of endometrial cancer. (author)

  15. Radiation therapy of the uterine cancer

    Energy Technology Data Exchange (ETDEWEB)

    Noguchi, Hiroshi [Matsumoto National Hospital, Nagano (Japan)

    1999-02-01

    Cervical and endometrial cancer of the uterus, and ovarian cancer are three major malignant diseases in gynecology in Japan. These diagnosis and therapy are almost established. In uterine cervical cancer, radiation therapy and surgery of these diseases are two main treatment methods, and both treatment results are almost the same. And radiation therapy is also used as postoperative treatment to patients with high risk factors. In endometrial cancer, surgery is main therapy. Radiation therapy is undergone only to medically inoperable cases preoperative radiation is widely carried out in Europe and America, but almost none in Japan. Postoperative irradiation is adapted to the cases with high risk factors. But recent advance of chemotherapy changes the importance of radiation therapy in such patients. I review the literatures of radiation therapy of uterine cervical cancer and of endometrial cancer. (author)

  16. High-dose-rate intra-cavitary brachytherapy combined with external beam radiation therapy for under 40-year-old patients with invasive uterine cervical carcinoma. Clinical outcomes in 118 patients in a Japanese multi-institutional study, JASTRO

    International Nuclear Information System (INIS)

    The current study was designed to evaluate the clinical outcomes of curative intent radiation therapy for young patients with invasive uterine cervical carcinoma in Japan. One hundred and eighteen patients aged ?40 were registered in the multi-institutional study of the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) from 26 major institutions in Japan. The age range was 24-39 years and the maximum tumor diameter was 2.0-9.2 cm. The International Federation of Gynecology and Obstetrics clinical stages were Ib, IIa, IIb, IIIa, IIIb and IVa in 17, 6, 40, 2, 50 and 3, respectively. Curative intent radiation therapy consisted of the combination of external beam radiation therapy and high-dose rate intra-cavitary brachytherapy. The total dose of external beam radiation therapy ranged between 44 and 68 Gy. Both the median and mode of total high-dose-rate intra-cavitary brachytherapy dose to point A were 24 Gy in four fractions. Ninety-six patients (58%) received chemotherapy. The 5-year overall survival rate and local control rate of all patients were 61 and 65%, respectively. The 5-year overall survival rates of International Federation of Gynecology and Obstetrics Stage Ib, IIa, IIb, IIIa, IIIb and IVa were 88, 100, 75, 100, 37 and 0%, respectively. The 5-year local control rates of International Federation of Gynecology and Obstetrics Stage Ib, IIa, IIb, IIIa, IIIb and IVa were 82, 75, 75, 100, 51 and 0%, respectively. Sixteen patients experienced gradevely. Sixteen patients experienced grade 3 or greater late radiation morbidity. The 5-year overall survival rate of young patients with Stage IIIb was comparatively low at 37%. (author)

  17. A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy

    Directory of Open Access Journals (Sweden)

    Kim Tae Hyun

    2013-01-01

    Full Text Available Abstract Purpose We assessed the value of dose-volumetric parameters predicting rectosigmoid mucosal changes (RMC and late rectosigmoid complications (LRC. Methods Between January 2004 and February 2006, 77 patients with stage IB-IIIB cervical cancer underwent external beam radiotherapy and computed tomography (CT-based intracavitary irradiation. Total dose to the rectal point and several dose-volumetric parameters for rectosigmoid colon (D20cc, D15cc, D10cc, D5cc, D2cc, D1cc, and D0.1cc , defined as the minimal doses received by the highest irradiated volumes of 20, 15, 10, 5, 2, 1, and 0.1 cc, respectively, were calculated using the equivalent dose in 2 Gy fractions (?/??=?3, Gy3. The RMC and LRC were graded by rectosigmoidoscopy and Radiation Therapy Oncology Group criteria every 6 months, respectively. Results Of 77 patients, 27 (35.1% patients developed RMC???score 3 and 22 (28.6 % patients developed LRC???grade 2. There was a positive correlation between RMC score and LRC grade (r?=?0.728, p?5cc, among the dose-volumetric parameters, was significant parameter for the risks of RMC???score 3 and LRC???grade 2 (p??0.05. Conclusions D5cc may be a more reliable estimate than other dose-volumetric parameters for predicting the risk of RMC???score 3 and LRC???grade 2 in CT-based brachytherapy.

  18. Sterility of the uterine cavity.

    DEFF Research Database (Denmark)

    MØller, B R; Kristiansen, F V

    1995-01-01

    In a prospective open study the sterility of the uterine cavity was evaluated in 99 women admitted for hysterectomy. The indications for hysterectomy were in most cases persistent irregular vaginal bleeding and fibromyomas of the uterus. Samples for both aerobic and anaerobic bacteria, Chlamydia trachomatis, yeasts and viruses were taken preoperatively from the apex of the vagina and cervical os. Immediately after hysterectomy the uterus was opened under sterile conditions and samples obtained from the isthmus and fundus of the uterine cavity for microbiological examination. Wet smears were taken from the same sites. Nearly a quarter of all the patients harbored one or more microorganisms in the uterus, mostly Gardnerella vaginalis, Enterobacter and Streptococcus agalactiae. We found that in a significant number of cases, the uterine cavity is colonized with potentially pathogenic organisms which may play a causative role in endometritis. The results indicate that inflammation of the uterine cavity should be evaluated by hysteroscopic examination before hysterectomy is undertaken in patients with persistent irregular vaginal bleeding. Udgivelsesdato: 1995-Mar

  19. [Uterine inversion].

    Science.gov (United States)

    Dirken, J J; Vlaanderen, W

    1994-01-01

    Inversion of the uterus is a rare complication of childbirth. A primigravida aged 21 and a multigravida aged 32, hospitalized as emergency cases because of inversion of the uterus with major blood loss, were treated with infusion of liquids (to combat shock), repositioning of the uterus under anaesthesia and prevention of reinversion by uterine tonics. Inversion of the uterus should be part of the differential diagnosis in every case of fluxus post partum. PMID:8289958

  20. HYSTEROSCOPY, A MINIMALLY INVASIVE METHOD FOR DIAGNOSIS AND TREATMENT OF UTERINE INFERTILITY

    OpenAIRE

    Nora (Dumitriu) Miron; Ivona Anghelache-Lupa?cu; Demetra Socolov; Cristina David; R.Socolov

    2011-01-01

    Hysteroscopy is an endoscopic procedure which consists of introducing a telescope connected to a camera through the dilated cervical canal into the uterine cavity for the visualisation of the cervical canal, uterine cavity and tubal ostiums. It is a minimally invasive method that allows diagnosis and / or treatment of a wide variety of pathologies affecting the proper functionality of internal female genitalia (menstrual and reproductive function). Objectives: It seeks to examine both the fre...

  1. Malignant Müllerian Mixed Tumor of the Uterine Cervix with a Small Cell Neuroendocrine Carcinoma Component

    OpenAIRE

    Munakata, Satoru; Iwai, Emi; Tanaka, Tomohito; Nakamura, Michihiko; Kanda, Takayoshi

    2013-01-01

    Malignant Müllerian mixed tumors (MMMTs) of the uterine cervix are extremely rare, accounting for 0.005% of all cervical malignancies. To date, only approximately 50 well-documented cases have been reported. Although several epithelial components have been described in cervical MMMTs, small cell neuroendocrine carcinoma (SCC) has not appeared in the English literature. We present a 43-year-old woman, para 2 gravida 2, who had MMMT with SCC and rhabdomyosarcoma components in the uterine cervi...

  2. Uterine Fibroid Embolization

    OpenAIRE

    Malek, R.; Padidar, A.

    2003-01-01

    Uterine fibroids are commonly asymptomatic. They often cause pelvic pain, abnormal and increased vaginal bleeding, etc. Traditional treatment of symptomatic uterine fibroids was trans-abdominal hysterectomy. Nowadays, uterine artery embolization (UAE), also called uterine fibroid embolization, is considered as a safe and highly-effective nonsurgical treatment for women with symptomatic uterine fibroid tumors. Advantages of UAE over conventional hormonal suppression and surgical procedures inc...

  3. Uterine metastasis of invasive ductal breast carcinoma diagnosed by cytological examination in an asymptomatic patient: an unusual case report

    Directory of Open Access Journals (Sweden)

    Ça?da? Türky?lmaz

    2007-10-01

    Full Text Available Uterine metastasis of malignant tumors occurs very rarely. Despite abnormal uterine bleeding is the most common symptom of metastatic uterine disease, less than 5% of patients may have not any gynecologic symptoms and diagnosis is made usually following abnormal cervical cytology. Here we present a case of uterine metastasis of invasive ductal breast carcinoma that was diagnosed by cervical cytological examination during breast cancer follow up. Even if there are not any gynecologic symptoms and findings in a patient who has breast cancer history, a detail systematic pelvic examination of these patients must be done yearly.

  4. Use of uterine electromyography to diagnose term and preterm labor

    OpenAIRE

    Lucovnik, Miha; Kuon, Ruben J.; Chambliss, Linda R.; Maner, William L.; Shi, Shao-qing; Shi, Leili; Balducci, James; Garfield, Robert E.

    2010-01-01

    Current methodologies to assess the process of labor, such as tocodynamometry or intrauterine pressure catheters, fetal fibronectin, cervical length measurement and digital cervical examination, have several major drawbacks. They only measure the onset of labor indirectly and do not detect cellular changes characteristic of true labor. Consequently, their predictive values for term or preterm delivery are poor. Uterine contractions are a result of the electrical activity within the myometrium...

  5. Runoff erosion

    OpenAIRE

    EVELPIDOU, NIKI; Cordier, Stephane; Merino, Agustin; Figueiredo, Tomás; Centeri, Csaba

    2013-01-01

    Table of Contents PART I – THEORY OF RUNOFF EROSION CHAPTER 1 - RUNOFF EROSION – THE MECHANISMS CHAPTER 2 - LARGE SCALE APPROACHES OF RUNOFF EROSION CHAPTER 3 - MEASURING PRESENT RUNOFF EROSION CHAPTER 4 - MODELLING RUNOFF EROSION CHAPTER 5 - RUNOFF EROSION AND HUMAN SOCIETIES: THE INFLUENCE OF LAND USE AND MANAGEMENT PRACTICES ON SOIL EROSION PART II - CASE STUDIES CASE STUDIES – INTRODUCTION: RUNOFF EROSION IN MEDITERRANEAN AREA CASE STUDY 1: Soil Erosio...

  6. Application of PDT for Uterine Cervical Cancer

    OpenAIRE

    Muroya, T.; Kawasaki, K.; Suehiro, Y.; Kunugi, T.; Umayahara, K.; Akiya, T; Iwabuchi, H.; Sakunaga, H.; Sakamoto, M; Sugishita, T.; Tenjin, Y.

    1999-01-01

    We have been performing PDT using Excimer Dye Laser (EDL) or YAG-OPO laser, a type of low power laser, both of which have a considerably higher degree of tissue penetration even when compared to PDT using Argon Dye Laser (ADL).

  7. Immature uterine teratoma associated with uterine inversion.

    Science.gov (United States)

    Souza, Karla Teixeira; Negrão, Marcelo Vailati; da Silva Rocha, Lucila Soares; Di Favero, Giovanni; da Costa, Samantha Cabral Severino; Diz, Maria Del Pilar Estevez

    2014-07-30

    Teratomas are the most commonly diagnosed germ cell tumors and occur primarily in testes and ovaries. Platinum-based therapy followed by surgical resection of the residual lesion is generally the recommended treatment. In contrast, immature uterine teratomas are rare, with few cases reported in the literature. Moreover, there is no standard treatment for these tumors. Non-puerperal uterine inversion is also rare in women younger than 45 years of age, and neoplastic lesions are responsible for this condition. Here, we report a case of an immature uterine teratoma associated with uterine inversion. The patient underwent surgery followed by adjuvant chemotherapy and continues to be monitored. PMID:25276328

  8. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available Uterine Fibroid Embolization Baptist Health South Florida Miami, FL March 25, 2010 Good afternoon, and welcome to the Baptist ... is going to be an embolization of uterine fibroids. So we're going to show you the ...

  9. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... old. She has very symptomatic uterine fibroids, very heavy menstrual periods. Her periods last on the order ... we see in women with uterine fibroids is heavy bleeding. In fact, some of our patients have ...

  10. Applicator for use of cesium-137 miniaturized tube sources in the treatment of uterine cervix cancer.

    Science.gov (United States)

    Kumar, P P; Good, R R; McCaul, G F

    1990-06-01

    A modified afterloading Kumar Cervical Applicator with a 3 mm diameter central tandem permits insertion of the afterloading tandem into the uterus without need of manual cervical dilatation. While general anesthesia is required for insertion of standard cervical applicators, this is eliminated because the central tandem is no larger than a uterine sound, and the tandem may be painlessly inserted into the uterus while the patient is awake. PMID:2370201

  11. Vaginal misoprostol for cervical priming before hysteroscopy

    Directory of Open Access Journals (Sweden)

    Valadan M

    2008-11-01

    Full Text Available "nBackground: As an important diagnostic and therapeutic procedure for patients with intrauterine diseases, hysteroscopy permits a good view of the uterine cavity, thereby increasing diagnostic accuracy. Complications often encountered during hysteroscopy primarily concern problems with cervical dilatation and include uterine perforation, cervical tears, and the creation of false tracts. In this study, we investigate the utility of vaginal misoprostol for cervical dilatation in women undergoing hysteroscopy. "nMethods: This triple-blind, randomized, placebo-controlled study was carried out at Mirza Khoochak Khan Hospital, Tehran, Iran. We excluded women who were pregnant, had genital tract infection, or history of cervical trauma. We randomly assigned 80 women with abnormal uterine bleeding or intrauterine lesions to receive either 200 ?g vaginal misoprostol or placebo. Ten to twelve hours prior to hysteroscopy, the placebo or misoprostol was administered to the posterior vaginal fornix. Data regarding cervical response and outcome of operative hysteroscopy, as well as complications, were analyzed. "nResults: The mean cervical width, as estimated by Hegar dilator, was significantly greater in the treated group (7.8±1.6mm than that in the control group (5.6±2.2mm, p<0.001. In the misoprostol group, 28 (70% patients required cervical dilatation, compared with 38(95% in the placebo group (p=0.001. A significantly shorter median time of cervical dilatation to Hegar number 9 was found in the treated subjects than in the controls (60 vs. 180 seconds, p<0.001. The mean operative time was significantly shorter in the treated group (8.8±8.7 minutes compared with that of the control group (13.1±10.1 minutes, p=0.043. "nConclusions: Vaginal misoprostol before operative hysteroscopy lessens the need for cervical dilatation, facilitating hysteroscopic surgery.

  12. Cervical wedge resection for treatment of pyometra secondary to transluminal cervical adhesions in six mares.

    Science.gov (United States)

    Arnold, Carolyn E; Brinsko, Steven P; Varner, Dickson D

    2015-06-15

    Case Description-6 mares with pyometra secondary to transluminal cervical adhesions were examined. Clinical Findings-Reasons for hospital admission included infertility (5 mares) and acute colic (1 mare). In the 6 mares, palpation per rectum of the reproductive tract revealed uterine distention, and transrectal ultrasonography confirmed the presence of echogenic fluid accumulation within the uterus. Cervical palpation during vaginal speculum examination indicated transluminal cervical adhesions. Three mares had severe distortion of the cervix as a result of diverticula and fibrosis. All 6 mares had a diagnosis of pyometra secondary to transluminal cervical adhesions. Treatment and Outcome-Initially, the cervical adhesions were manually broken down to establish a patent cervical lumen to accommodate a uterine lavage catheter. A sample of the uterine content was obtained for bacteriologic culture and antimicrobial susceptibility testing, and the uterus was lavaged with 0.05% povidone-iodine solution to remove the mucopurulent exudate. Once the uterus was evacuated, cervical surgery was performed in standing mares following sedation and caudal epidural anesthesia. A full-thickness wedge-shaped defect was made in the dorsolateral aspect of the cervix that created a permanent opening to the uterus. Postoperative care included applying topical medication to the cervix to reduce the recurrence of adhesion formation. All 6 mares had patent cervices and resolution of pyometra following surgery. Conclusions and Clinical Relevance-Cervical wedge resection enabled treatment of pyometra in mares with transluminal cervical adhesions, without the need for ovariohysterectomy. (J Am Vet Med Assoc 2015;246:1354-1357). PMID:26043134

  13. Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis

    Scientific Electronic Library Online (English)

    José Roosevelt, Cavalcante; João Paulo Aguiar, Sampaio; João Tarcísio Alves, Maia Filho; Renato Braga, Vieira; José, Eleutério Júnior; Roberto César Pereira, Lima Júnior; Ronaldo Albuquerque, Ribeiro; Paulo Roberto Carvalho, Almeida.

    2014-10-01

    Full Text Available PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases [...] of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer.

  14. Malignant mixed mullerian tumor arising from the uterine cervix: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Jong Joon; Shim, Jae Chan; Lee, Kyoung Eun; Lee, Ghi Jai; Kim, Ho Kyun; Suh, Jung Ho; Lee, Hye Kyung [Seoul Paik Hospital/Inje Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-10-15

    Malignant mixed mullerian tumors (MMMTs) are a rare uterine tumor and contribute to approximately 1-3% of all corpus malignant tumors. MMMTs are usually in the uterine corpus, but can also arise from the uterine cervix, vagina, ovaries and fallofian tubes. MMMTs of the uterine cervix are extremely rare. MMMTs are highly malignant and tend to maintain a rapid growth and exhibit a high rate of recurrence. Therefore, the prognosis of patients diagnosed with these types of tumors is extremely poor. We report a rare case of a malignant mixed mullerian tumor arising from the uterine cervix and introduce CT and MRI findings. CT and magnetic resonance findings of the uterine cervical MMMT in our case show highly aggressive features, such as parametrial involvement, pelvic and paraaortic lymphadenopathy, and distant metastasis and high enhancement.

  15. Uterine cervical carcinoma: a comparison of two- and three-dimensional T2-weighted turbo spin-echo MR imaging at 3.0 T for image quality and local-regional staging

    International Nuclear Information System (INIS)

    To compare three-dimensional (3D) T2-weighted turbo spin-echo (TSE) with multiplanar two-dimensional (2D) T2-weighted TSE for the evaluation of invasive cervical carcinoma. Seventy-five patients with cervical carcinoma underwent MRI of the pelvis at 3.0 T, using both 5-mm-thick multiplanar 2D (total acquisition time = 12 min 25 s) and 1-mm-thick coronal 3D T2-weighted TSE sequences (7 min 20 s). Quantitative analysis of signal-to-noise ratio (SNR) and qualitative analysis of image quality were performed. Local-regional staging was performed in 45 patients who underwent radical hysterectomy. The estimated SNR of cervical carcinoma and the relative tumour contrast were significantly higher on 3D imaging (P < 0.0001). Tumour conspicuity was better with the 3D sequence, but the sharpness of tumour margin was better with the 2D sequence. No significant difference in overall image quality was noted between the two sequences (P = 0.38). There were no significant differences in terms of the diagnostic accuracy, sensitivity, and specificity of parametrial invasion, vaginal invasion, and lymph node metastases. Multiplanar reconstruction 3D T2-weighted imaging is largely equivalent to 2D T2-weighted imaging for overall image quality and staging accuracy of cervical carcinoma with a shorter MR data acquisition, but has limitations with regard to the sharpness of the tumour margin. circle 3D T2-weighted MR sequence is equivalent to 2D for cervical carcinoma staging. (orig.)cervical carcinoma staging. (orig.)

  16. Uterine artery embolization to treat uterine fibroids

    International Nuclear Information System (INIS)

    The first reported application of uterine artery embolization, in 1979, was to treat life-threatening hemorrhage after a failed hysterectomy. Since then, uterine artery embolization has been used very successfully to control acute or delayed post-partum hemorrhage, post-surgical hemorrhage and hemorrhage from ectopic pregnancy, to treat uterine arteriovenous malformations and as prophylaxis before high-risk surgery, such as cesarean delivery in women with placenta previa. In contrast to these proven but underutilized applications, uterine embolization for fibroids has, in a short time, achieved significant notice in the lay press and is being widely offered. Ravina and colleagues, first reported uterine fibroid shrinkage after embolization for the treatment of acute bleeding. Since then, his group has performed over 100 procedures with up to a 6-year follow-up. The cumulative clinical success rate for the treatment of abnormal uterine bleeding due to fibroids is reported to be approximately 85% and for treatment of pain or pressure symptoms, about 75%. Six-month follow-up sonography reveals an average reduction of fibroid size of approximately 40%. However, to date, no studies have compared patients who undergo embolization with a nontreatment cohort or with surgical intervention. (author)

  17. Uterine artery embolization to treat uterine fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Machan, L.; Martin, M. [Univ. of British Columbia Hospital, Dept. of Radiology, Vancouver, BC (Canada)

    2001-06-01

    The first reported application of uterine artery embolization, in 1979, was to treat life-threatening hemorrhage after a failed hysterectomy. Since then, uterine artery embolization has been used very successfully to control acute or delayed post-partum hemorrhage, post-surgical hemorrhage and hemorrhage from ectopic pregnancy, to treat uterine arteriovenous malformations and as prophylaxis before high-risk surgery, such as cesarean delivery in women with placenta previa. In contrast to these proven but underutilized applications, uterine embolization for fibroids has, in a short time, achieved significant notice in the lay press and is being widely offered. Ravina and colleagues, first reported uterine fibroid shrinkage after embolization for the treatment of acute bleeding. Since then, his group has performed over 100 procedures with up to a 6-year follow-up. The cumulative clinical success rate for the treatment of abnormal uterine bleeding due to fibroids is reported to be approximately 85% and for treatment of pain or pressure symptoms, about 75%. Six-month follow-up sonography reveals an average reduction of fibroid size of approximately 40%. However, to date, no studies have compared patients who undergo embolization with a nontreatment cohort or with surgical intervention. (author)

  18. Cervical Cancer

    Centers for Disease Control (CDC) Podcasts

    2007-03-06

    Did you know that cervical cancer rates differ by race/ethnicity and region? Or that cervical cancer can usually be prevented if precancerous cervical lesions are found by a Pap test and treated? Find out how getting regular Pap tests can save a woman's life.  Created: 3/6/2007 by National Breast and Cervical Cancer Early Detection Program.   Date Released: 4/25/2007.

  19. Abnormal Uterine Bleeding

    Science.gov (United States)

    ... bleeding? • Glossary Abnormal Uterine Bleeding • Use of some birth control methods, such as an intrauterine device (IUD) or birth control pills • Infection of the uterus or cervix • Fibroids • ...

  20. ANALISIS CRITICO DEL MANEJO DE LA INCOMPETENCIA CERVICAL

    Scientific Electronic Library Online (English)

    Víctor, Miranda H; Jorge A, Carvajal C.

    Full Text Available La incompetencia cervical se caracteriza por la dilatación progresiva del cuello uterino en ausencia de contracciones uterinas. Esta condición es causa de aborto de segundo trimestre y parto prematuro. Clásicamente el tratamiento ha sido el cerclaje cervical, cuya utilidad, sin embargo, no ha sido d [...] emostrada. La evidencia disponible, y el uso clínico habitual sugiere que el grupo de pacientes con historia clínica característica de incompetencia cervical (abortos repetidos de segundo trimestre secundarios a dilatación cervical pasiva), se beneficiarían del cerclaje cervical en forma electiva entre las 12-14 semanas. Sin embargo, la evidencia no es concluyente respecto de cuál es la mejor opción terapéutica para las pacientes sin historia característica, pero en riesgo de incompetencia cervical (acortamiento cervical ecográfico o antecedente de parto prematuro). Se requiere de estudios randomizados de buen diseño para resolver la pregunta en cada grupo Abstract in english Cervical Incompetence is characterized by progressive cervical dilation in the absence of uterine contractions, leading to second trimester abortion and preterm birth. Cerclage has been used for Cervical Incompetence however its efficacy has not been confirmed. The best evidence and clinical judge s [...] uggest that those patients with classical history of cervical incompetence (recurrent painless dilation and spontaneous midtrimester abortion) will benefit of elective cerclage at 12-14 weeks. However, the evidence is not conclusive for patients with no history, but at risk of cervical incompetence (cervical shortening evidenced by ultrasound or antecedents of preterm birth). Randomized trials are needed to answer this question for each group

  1. ANALISIS CRITICO DEL MANEJO DE LA INCOMPETENCIA CERVICAL

    Directory of Open Access Journals (Sweden)

    Víctor Miranda H

    2003-01-01

    Full Text Available La incompetencia cervical se caracteriza por la dilatación progresiva del cuello uterino en ausencia de contracciones uterinas. Esta condición es causa de aborto de segundo trimestre y parto prematuro. Clásicamente el tratamiento ha sido el cerclaje cervical, cuya utilidad, sin embargo, no ha sido demostrada. La evidencia disponible, y el uso clínico habitual sugiere que el grupo de pacientes con historia clínica característica de incompetencia cervical (abortos repetidos de segundo trimestre secundarios a dilatación cervical pasiva, se beneficiarían del cerclaje cervical en forma electiva entre las 12-14 semanas. Sin embargo, la evidencia no es concluyente respecto de cuál es la mejor opción terapéutica para las pacientes sin historia característica, pero en riesgo de incompetencia cervical (acortamiento cervical ecográfico o antecedente de parto prematuro. Se requiere de estudios randomizados de buen diseño para resolver la pregunta en cada grupoCervical Incompetence is characterized by progressive cervical dilation in the absence of uterine contractions, leading to second trimester abortion and preterm birth. Cerclage has been used for Cervical Incompetence however its efficacy has not been confirmed. The best evidence and clinical judge suggest that those patients with classical history of cervical incompetence (recurrent painless dilation and spontaneous midtrimester abortion will benefit of elective cerclage at 12-14 weeks. However, the evidence is not conclusive for patients with no history, but at risk of cervical incompetence (cervical shortening evidenced by ultrasound or antecedents of preterm birth. Randomized trials are needed to answer this question for each group

  2. Uterine cervical carcinoma: a comparison of two- and three-dimensional T2-weighted turbo spin-echo MR imaging at 3.0 T for image quality and local-regional staging

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Y.R. [The Catholic University of Korea, Department of Radiology, Seoul St. Mary' s Hospital, College of Medicine, 222, Banpo-daero, Seocho-gu, Seoul (Korea, Republic of); The Catholic University of Korea, Department of Radiology, Incheon St. Mary' s Hospital, College of Medicine, Bupyeong 6-dong, Bupyeong-gu, Incheon (Korea, Republic of); Rha, S.E.; Choi, B.G.; Oh, S.N.; Park, M.Y.; Byun, J.Y. [The Catholic University of Korea, Department of Radiology, Seoul St. Mary' s Hospital, College of Medicine, 222, Banpo-daero, Seocho-gu, Seoul (Korea, Republic of)

    2013-04-15

    To compare three-dimensional (3D) T2-weighted turbo spin-echo (TSE) with multiplanar two-dimensional (2D) T2-weighted TSE for the evaluation of invasive cervical carcinoma. Seventy-five patients with cervical carcinoma underwent MRI of the pelvis at 3.0 T, using both 5-mm-thick multiplanar 2D (total acquisition time = 12 min 25 s) and 1-mm-thick coronal 3D T2-weighted TSE sequences (7 min 20 s). Quantitative analysis of signal-to-noise ratio (SNR) and qualitative analysis of image quality were performed. Local-regional staging was performed in 45 patients who underwent radical hysterectomy. The estimated SNR of cervical carcinoma and the relative tumour contrast were significantly higher on 3D imaging (P < 0.0001). Tumour conspicuity was better with the 3D sequence, but the sharpness of tumour margin was better with the 2D sequence. No significant difference in overall image quality was noted between the two sequences (P = 0.38). There were no significant differences in terms of the diagnostic accuracy, sensitivity, and specificity of parametrial invasion, vaginal invasion, and lymph node metastases. Multiplanar reconstruction 3D T2-weighted imaging is largely equivalent to 2D T2-weighted imaging for overall image quality and staging accuracy of cervical carcinoma with a shorter MR data acquisition, but has limitations with regard to the sharpness of the tumour margin. circle 3D T2-weighted MR sequence is equivalent to 2D for cervical carcinoma staging. (orig.)

  3. Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia

    Directory of Open Access Journals (Sweden)

    Yaliana Tafurt-Cardona

    2012-02-01

    Full Text Available Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron entrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %, 36 citología anormal (2 % y 638 cambios celulares reactivos asociados a inflamación (37 %. Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país.Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire to collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %, 36 abnormal cytology (2 % and 638 reactive cellular changes associated with inflammation (37 %. The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

  4. Prevalencia de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en el Cauca, Colombia / The prevalence of abnormal cytology and inflammation and their association with risk factors for uterine cervical neoplasms in Cauca, Colombia

    Scientific Electronic Library Online (English)

    Yaliana, Tafurt-Cardona; Claudia P., Acosta-Astaiza; Carlos H., Sierra-Torres.

    2012-02-01

    Full Text Available Objetivos Establecer la prevalencia del resultado de citología anormal e inflamación y su asociación con factores de riesgo para neoplasias del cuello uterino en mujeres del departamento del Cauca, Colombia. Metodología Después de la Arma voluntaria del consentimiento informado, las mujeres fueron e [...] ntrevistadas a través de un cuestionario para colectar variables de tipo sociodemográfico y clínico, incluyendo historia reproductiva, actividad sexual, historia de citología y hábito de fumar. Posteriormente, se procedió a la toma de la citología para su análisis y clasificación según el sistema Bethesda 2001. Un total de 1735 mujeres fueron reclutadas para este estudio. Resultados Acorde con el resultado de citología, 1061 mujeres presentaron citología normal (61 %), 36 citología anormal (2 %) y 638 cambios celulares reactivos asociados a inflamación (37 %). Los resultados indican que tener relaciones sexuales a temprana edad, la multiparidad, el uso de anticonceptivos hormonales y no realizarse la citología anualmente fueron factores de riesgo asociados a citología anormal. Conclusiones Estos resultados brindan información valiosa a las instituciones de salud pública para desarrollar mejores programas de cribado para la prevención de neoplasias del cuello uterino en mujeres de la región y el país. Abstract in english Objectives Establishing the prevalence of abnormal and inflammation cytology reports and its association with risks factors for uterine cervical neoplasms amongst females from the Cauca department in Colombia. Methodology After signing a consent-form, females were interviewed using a questionnaire t [...] o collect socio-demographic and clinical data, including reproductive history, sexual activity, cytology history and smoking habits. Cytology was then taken for analysis and classification according to the 2001 Bethesda System. A total of 1,735 females were recruited for the study. Results According to the cytology report, 1061 women had normal cytology (61 %), 36 abnormal cytology (2 %) and 638 reactive cellular changes associated with inflammation (37 %). The results indicated that having sexual intercourse at an early age, multiparity, using hormonal contraceptives and not having annual cytology screening were associated with abnormal cytology reports. Conclusions These results provided valuable information for public health institutions for developing better screening programmes to prevent risks of uterine cervical neoplasms amongst females from our region and throughout Colombia.

  5. Importancia de los estudios de inmunohistoquímica en el diagnóstico y la evaluación pronóstica de la neoplasia intraepitelial y el cáncer cervical: Revisión / Importance of immunohistochemical studies in the diagnosis and the prognostic evaluation of cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix: Review

    Scientific Electronic Library Online (English)

    Jorge, García-Tamayo; Julia, Molina; Eduardo, Blasco-Olaetxea.

    2009-06-01

    Full Text Available Se evaluó la expresión de proteínas dependientes de genes en el epitelio cervical, en la neoplasia intraepitelial cervical (NIC) y en el carcinoma del cuello uterino (CC) a través de diversos estudios de inmunohistoquímica (IHQ). Se examinó la detección de ciertas proteínas como p53, bcl2, C-Myc, Ki [...] 67, Ciclinas, P16 INK4a, p21, p27, b-catenina, Wnt y MCM, en relación con la evolución de la neoplasia intraepitelial, el carcinoma cervical y la infección con el virus del papiloma humano (VPH). Se señaló como la actividad transcripcional de diversos genes provoca alteraciones de la heterocigosis y pérdida de regiones cromosómicas que influyen en la sobrexpresión de proteínas o en la pérdida parcial de la expresión de algunas glicoproteínas en la superficie celular por la activación de genes del VPH. Abstract in english Immunohistochemical studies in cervical intraepithelial neoplasia and cervical carcinoma are evaluated in this review. A variety of proteíns like p53, bcl2, C-Myc, Ki 67, Cyclines, P16 INK4a, p21, p27, b-catenin, Wnt and MCM, have been related to the development of cervical neoplasia and human papil [...] loma virus infection. It is described how transcriptional factors of genes induce loss of heterozygosity, numerical chromosome abnormality and inactivation of gene products or the partial loss of some membrane glycoproteins induced by oncogenic human papillomaviruses (HPV).

  6. Avaliação da medida do comprimento do colo e da ausência do eco glandular endocervical para predição do parto pré-termo / Evaluation of risk for preterm delivery by measurement of uterine cervix and cervical gland area

    Scientific Electronic Library Online (English)

    Claudio Rodrigues, Pires; Antonio Fernandes, Moron; Rosiane, Mattar; Luiz, Kulay Júnior.

    2004-04-01

    Full Text Available OBJETIVO: verificar a prevalência do sinal eco glandular endocervical (EGE) e o comprimento cervical menor ou igual a 20 mm em gestantes entre a 21ª e a 24ª semana e comparar estes sinais ecográficos como fatores indicadores de parto pré-termo espontâneo. MÉTODOS: estudo prospectivo transversal no q [...] ual foram incluídas 361 gestantes da população geral, para realização de exame ultra-sonografico em idade gestacional entre a 21ª a 24ª semana. Os critérios de exclusão do estudo foram malformações müllerianas, gestações múltiplas, malformações fetais, óbito fetal, alterações da quantidade de líquido amniótico, placenta com inserção segmentar, antecedentes de cirurgia no colo uterino (conização, amputação, cerclagem) e procedimentos cirúrgicos durante a gestação. Após a realização do exame ultra-sonográfico obstétrico morfológico efetuado por via abdominal, seguiu-se o exame ecográfico por via vaginal para observação de uma faixa hipoecóica ou hiperecóica adjacente ao canal endocervical correpondente às glândulas do epitélio endocervical (EGE) e mensuração do comprimento cervical. As variáveis qualitativas são representadas por freqüência absoluta e relativa, ao passo que as variáveis quantitativas, por média, desvio-padrão, mediana e valores mínimo e máximo. A associação entre as variáveis qualitativas foi avaliada pelo teste c² ou teste exato de Fisher. Para cada variável estudada, foi calculado o risco relativo seguido do intervalo com 95% de confiança. A técnica de análise de regressão logística univariada foi utilizada para verificar, entre as variáveis estudadas, quais foram indicativas de parto pré-termo espontâneo. O nível de significância adotado foi de 95% (alfa = 5%) e descritivos (p) iguais ou inferiores a 0,05 foram considerados significantes. RESULTADOS: a incidência do parto pré-termo espontâneo foi de 5,0%. O comprimento do colo uterino revelou-se igual ou inferior a 20 mm em 3,3% da população estudada e em 27,8% das pacientes que apresentaram parto pré-termo espontâneo. A ausência do EGE foi detectada em 2,8% das pacientes estudadas e em 44,4% das pacientes que evoluíram para parto pré-termo espontâneo. A associação entre ausência do EGE e presença do colo curto revelou-se estatisticamente significante (p Abstract in english PURPOSE: to verify the prevalence of two sonographic findings, the cervical gland area (CGA) feature and the cervical length of less than 20 mm, and to compare these with the risk for premature delivery in pregnant women between 21 and 24 weeks' gestation. METHOD: this was a prospective, cross-secti [...] onal study in which 361 women were consecutively examined by transvaginal ultrasonography. Müllerian or other malformations, multiple gestations, fetal death, olygo- or polyhydramnios, marginal placenta previa, and conization, cerclage, amputation or other surgical procedures in the cervix, prior to or during pregnancy, were exclusion criteria. After the abdominal ultrasonographic morphological examination, we used transvaginal ultrasonography to measure the cervical length and to observe the presence of hyper- or hypoechoic area next to the endocervical canal, a feature characteristic of endocervical epithelium glands which is called CGA (cervical gland area). Qualitative variables are expressed as absolute and relative frequency. Quantitative variables are expressed as mean, median, standard deviation, minimum, and maximum values. Association between qualitative variables was detected by the c² test or by the Fisher exact test. For each variable, the relative risk and the 95% confidence interval (CI) were calculated. Logistic regression analysis was used to calculate the predictive values for premature delivery. Significance level was 95% (alpha = 5%), with descriptive (p) values equal or lower than 0.05 considered significant. RESULTS: spontaneous preterm delivery occurred in 5.0% of the patients. Cervical length was up to 20 mm in 3.3% of all studied patients and i

  7. Uterine leiomyosarcoma: A case report

    OpenAIRE

    Kaur, Khushpreet; Kaur, Parneet; Kaur, Arvinder; Singla, Atish

    2014-01-01

    Uterine leiomyosarcoma is a rare uterine malignancy that arises from the smooth muscles of uterine wall. It accounts for only 1-2% of uterine malignancies. We report a case of a 60-year-old female who presented with postmenopausal bleeding and was diagnosed later to be a case of leiomyosarcoma of uterus. The diagnosis of leiomyosarcoma is made by histopathological examination, and surgery is the only treatment. The prognosis for female with uterine sarcoma primarily depends on the extent of d...

  8. Uterine Fibroid Embolization

    Directory of Open Access Journals (Sweden)

    "R. Malek

    2003-06-01

    Full Text Available Uterine fibroids are commonly asymptomatic. They often cause pelvic pain, abnormal and increased vaginal bleeding, etc. Traditional treatment of symptomatic uterine fibroids was trans-abdominal hysterectomy. Nowadays, uterine artery embolization (UAE, also called uterine fibroid embolization, is considered as a safe and highly-effective nonsurgical treatment for women with symptomatic uterine fibroid tumors. Advantages of UAE over conventional hormonal suppression and surgical procedures include avoidance of the side effects of drug therapy and surgery-related physical and psychological trauma. These patients commonly resume their normal activities within a week after the procedure; weeks earlier than that for trans-abdominal hysterectomy. Over the past 30 years, interventional radiologists have done UAE for treatment of emergency uterine bleeding. Since 1995, interventional radiologists have turned their attention to treatment of uterine fibroids with a similar procedure. The first fibroid embolization in Iran was done approximately three years ago. So far, more than 100 cases have been treated by this method and it is going to be quickly accepted as a safe alternate for surgery.

  9. Normal uterine activity on a sup(99m)Tc-glucoheptonate renal scan

    International Nuclear Information System (INIS)

    Uterine radioactivity uptake has previously been reported for a variety of radionuclide agents in the presence of uterine pathological disorders, such as leiomyomata as well as uterine and cervical neoplasma and infections. Activity within the normal uterus has also been reported in Meckel's scans using sup(99m)Tc-pertechnetate, but this has not been reported for other radionuclide agents. We report a case exhibiting radioactivity uptake within a normal uterus on a sup(99m)Tc-glucoheptonate scan of a renal transplant. Awareness of the possibility of radioactivity uptake in a normal uterus is important in order to avoid potential confusion with abnormal pelvic masses or fluid occumulations. (orig.)

  10. Uterine Leiomyoma: Hysterosalpingographic Appearances

    Directory of Open Access Journals (Sweden)

    Firoozeh Ahmadi

    2008-01-01

    Full Text Available Uterine leiomyoma is the most common benign tumor of genital tract. The etiology of myomasis unknown. Leiomyoma shows a broad spectrum of radiographic appearances depending on thenumber, size, and location of the tumor. The diagnostic method for uterine leiomyomas is basedprimarily on the clinical situation. Despite of the varied diagnostic options such as; transvaginalsonography, sonohysterography, hysteroscopy, laparoscopy and MRI; hysterosalpingography isstill one of the valuable imaging methods for identification of uterine leiomyoma.The various features of the proved leiomyoma are illustrated in this pictorial review. The incidence,risk factors and clinical features will also be discussed briefly.

  11. A Case of Adenoid Basal Carcinoma of the Uterine Cervix

    OpenAIRE

    Kim, Hwi-gon; Song, Yong Jung; Na, Yong Jin; Choi, Ook-hwan

    2013-01-01

    Adenoid basal carcinoma of the uterine cervix is uncommon neoplasia mostly occurring in postmenopausal women. It has excellent prognosis and a favorable clinical course. In addition, adenoid basal carcinoma is differentiated from adenoid cystic carcinoma by histologic and cellular morphologies, and immunohistochemistry. In this paper, we present the case of a 22 year old Korean female. She initially had a high-grade squamous intraepithelial lesion (HSIL) on Pap smear and a subsequent cervical...

  12. Sexual behaviour of women with human papillomavirus (HPV) lesions of the uterine cervix.

    OpenAIRE

    Syrjänen, K.; Väyrynen, M; Castrén, O; Yliskoski, M; Mäntyjärvi, R; Pyrhönen, S; Saarikoski, S.

    1984-01-01

    To analyse the epidemiological aspects contributing to the transmission of human papillomavirus (HPV) lesions (flat, inverted, and papillomatous condylomas) of the uterine cervix, we recorded the sexual behaviour of 146 women who consecutively attended the department of obstetrics and gynaecology of Kuopio University Central Hospital with a cervical HPV lesion (with or without concomitant cervical intraepithelial neoplasia (CIN]. Similar data were collected from an age matched group of women ...

  13. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... And what we see here is a very abnormal uterine artery, the very rich blood supply. And ... the uterus. But, by and large, that very abnormal area that we saw going to the fibroids ...

  14. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... Cardiac and Vascular Institute, we've performed almost 1,000 uterine fibroid embolizations. Fibroids are common, benign ... embolization procedure. More contrast, please. Thanks, Dr. Powell. One thing I did want to mention. You heard ...

  15. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... and fall into the uterine cavity, in which case we would refer you back to your gynecologist ... through the sheath. And we're using a series of small wires and these catheters that fit ...

  16. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... parts of it can actually break off and fall into the cavity. And a small percentage of ... fibroid, instead of shrinking, may break off and fall into the uterine cavity, in which case we ...

  17. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... has very symptomatic uterine fibroids, very heavy menstrual periods. Her periods last on the order of eight days, four ... painful intercourse, and very heavy and crampy menstrual periods. If we can come to our diagram here, ...

  18. Subserous Uterine Leiomyoma

    OpenAIRE

    Rusda, Muhammad; Adrian

    2010-01-01

    Uterine fibroids are the most common pelvic tumor. The growth of a fibroid seems to depend on the hormone estrogen. As long as a woman with fibroids is menstruating, the fibroids will probably continue to grow, usually slowly. Management of uterine myomas may involve one of the following approaches or a combination thereof: expectant management, medical management. A case of subserous leiomyoma in a 20-year old, virgin is hereby presented. She underwent myomectomy for a preoperative adnexal m...

  19. Cervical thymoma

    Scientific Electronic Library Online (English)

    Abrão, Rapoport; Claudiane Ferreira, Dias; João Paulo Aché de, Freitas; Ricardo Pires de, Souza.

    1999-05-06

    Full Text Available CONTEXTO: O timoma cervical é neoplasia primitiva do timo. Sua incidência é muito rara. Esta doença apresenta maior incidência em pacientes do sexo feminino, entre a quarta e sexta décadas. RELATO DE CASO: Apresentamos o caso de uma paciente do sexo feminino, 54 anos, com timoma cervical. Durante o [...] período de dois anos e meio de investigação teve evolução assintomática com crescimento progressivo do nódulo cervical, próximo à tireóide. A paciente não apresentou alterações dos exames de função tireoidiana ou dos exames subsidiários realizados. O diagnóstico de timoma cervical foi realizado no intra-operatório sendo conclusivo com o estudo anatomopatológico da peça retirada. O timoma cervical é raro, com difícil diagnóstico pré-operatório. Atualmente utiliza-se métodos complementares para o diagnóstico preciso como: a cintilografia com Tálio 201, o Tecnésio 99 e o Iodo 131, além da ressonância nuclear magnética e, principalmente, realizando o estudo e classificação histopatológica. Abstract in english CONTEXT: Cervical thymoma is a primitive thymic neoplasia. It is very rare. This disease presents higher incidence in female patients in their 4th to 6th decade of life. We present a case report of a cervical thymoma CASE REPORT: 54-year-old female patient, caucasian, with no history of morbidity, p [...] resenting a left cervical nodule close to the thyroid gland. During the 30 months of investigation a left cervical nodule grew progressively next to the thyroid while the patient showed no symptoms, making accurate diagnosis difficult. Tests on her thyroid function did not show changes, nor were there changes in any subsidiary tests. The diagnosis of the disease was made intra-operatively through total thyroid individualization. The results were confirmed by the histological findings from the ressected material. Cervical thymoma is a very rare disease, with difficult preoperatory diagnosis. Some additional study methods which are employed today are thallium 201, technetium 99 and iodine 131 scintigraphy, magnetic nuclear resonance and especially histopathological findings and classification.

  20. MRI of the occipito-cervical junction in rheumatoid arthritis

    International Nuclear Information System (INIS)

    Magnetic resonance imaging and conventional radiographs and tomograms were correlated in 61 patients with chronic polyarthritis. Radiographs of the occipito-cervical junction only demonstrated bone lesions, erosions were detected on conventional tomograms. MRI was adequate for demonstration of bone abnormalities and soft tissue lesion and was especially suitable for detection of complications at the cervical spinal cord. (orig.)

  1. Unusual presentation of uterine leiomyoma.

    Science.gov (United States)

    Al Hadidi, Samer; Shaik Mohammed, Tabrez; Bachuwa, Ghassan

    2015-01-01

    Uterine leiomyoma is the most common pelvic tumour in women. The presentation of uterine leiomyoma varies. Symptoms may include abnormal uterine bleeding or abdominal pressure and heaviness; however, most cases are asymptomatic. We report a case with renal impairment as the first presentation of uterine leiomyoma in a patient who presented with extensive bilateral lower limb oedema and no menstrual symptoms. Imaging studies, a subsequent Papanicolaou test and uterine biopsy were suggestive of uterine leiomyoma, which was confirmed by pathological examination after hysterectomy. The patient's kidney impairment resolved completely after the procedure. PMID:25858937

  2. Adenocarcinoma of the Uterine Cervix

    International Nuclear Information System (INIS)

    Survival data, prognostic factors, and patterns of failure were retrospectively analyzed for a total of 76 patients with adenocarcinoma of the uterine cervix treated between January 1981 and December 1987, which represents 4.1% of all primary cervical carcinomas treated, at Department of Radiation Oncology, Yensei Cancer Center, Yonsei University College of Medicine. The mean age of the patients was 49years(range, 27-79years) and the peak incidence was in the group 50 to 59years of age. More half of the patients were postmenopausal (46/76=60.5%). Most patients(76%)had abnormal vaginal bleeding either alone or in combination with other symptoms. The proportion of stage Iib was 43.4%. There were 4 major histologic subtypes: pure adenocarcinoma(48/76=63.2%), adenosquamous carcinoma(20/76=26.3%), papillary (5/76=6.6%) and clear cell carcinoma(3/76=3.9%). Of the many clinicopathologic variables evaluated for prognosis, the most significant prognostic factors were stage of disease and the size of tumor. The overall 5-year survival rate was 68%, and the 5-year survival rates for stage Ib, II and III were 90%, 66% and 54%, respectively. Control of pelvic tumors was achieved in 938%, 90.2% and 50.0% of cases of stage Ib, II and III disease, respectively. In present study, treatment modalities (radiation therapy alone/combined operative and radiation therapy) did not affect the local control of tumor and the survival

  3. Dosimetric comparison of IMRT and modulated arc-therapy techniques in the treatment of cervical cancers; Comparaison dosimetrique des techniques de RCMI et d'arctherapie modulee dans le traitement des cancers du col uterin

    Energy Technology Data Exchange (ETDEWEB)

    Renard-Oldrini, S.; Charra-Brunaud, C.; Tournier-Rangeard, L.; Huger, S.; Marchesi, V.; Bouziz, D.; Peiffert, D. [Centre Alexis-Vautrin, Nancy (France)

    2011-10-15

    The authors report the dosimetric comparison of two techniques used for the treatment of cervical cancers: the intensity-modulated conformational radiotherapy (IMRT) with static beams and modulated arc-therapy with RapidArc. The treatment plans of 15 patients have been compared. The clinical target volume (CTV) comprises the gross target volume, the cervix, the upper third of the vagina, and ganglionary areas. The previsional target volume comprises the clinical target volume and a one centimetre margin. Organs at risk are rectum, bladder, intestine and bone marrow. Arc-therapy seems to provide a better sparing of intestine that IMRT, while maintaining a good coverage of the previsional target volume and decreasing treatment duration. Short communication

  4. RAPIDARC (RA) in the uterine cervical cancer; dosimetric gain vs 3D-Crt; RAPIDARC (RA) en el cancer de cervix uterino; ganancia dosimetrica vs 3D-CRT

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, J.; Garcia, B.; Quispe, K.; Gonzales, A.; Marquina, J., E-mail: jose.ramirez@aliada.com.pe [Clinica Aliada, Oncologia Integral, Av. Jose Galvez Barrenechea 1044, San Isidro, Lima (Peru)

    2014-08-15

    This work aims to quantitatively assess RAPIDARC (RA) treatments versus three dimensional-Conformal Radiation Therapy with field to field technique (3D-Crt-Fin F). 11 patients with cervical cancer treated at our institution radically or adjuvant clinical stages I-III B were evaluated. The prescribed dose was 50 Gy (2 Gy / Fr). The RA plans consisted of two isocentric complete arcs and conformational plans of 4 isocentric fields (previous, subsequent, right side and left side) with 3D-Crt-Fin F technique; both cases carried out ??in the Eclipse version 10 planner with calculation algorithm analytical anisotropic algorithm (AAA) and volumetric optimization software (for VMAT plans). Homogeneity indices (Hi), conformity indices (CI) Sigma indices (S-Index), monitor units (MU) and the time required for each treatment were compared. The mean age was 52 years (32-65) of the 11 patients 9 were clinical stages I-II B. The Hi varied from 0.052 for RA to 0.163 for 3D-Crt-Fin F (p = 0.009), and the CI between 1.005 and 1.35 (p = 0.26), the S-index from 1.2 to 3.7 (p = 0.001) and the H-index of 1.08 to 1.15 (p = 0.24). All dose limits in risk organs were met with a significant difference in the RA plans versus 3D-Crt-Fin F. In patients with cervical cancer the treatment plans quality with the indices aforementioned seems to be better with the RA technique, being observed a significant reduction of radiation to surrounding organs. (author)

  5. How Are Uterine Fibroids Diagnosed?

    Science.gov (United States)

    ... Clinical Trials Resources and Publications How are uterine fibroids diagnosed? Skip sharing on social media links Share ... probably won’t know that you have uterine fibroids. Sometimes, health care providers find fibroids during a ...

  6. Conhecimento das mulheres sobre o câncer cérvico-uterino - DOI: 10.4025/actascihealthsci.v26i2.1582 Women’s knowledge of cervical uterine cancer - DOI: 10.4025/actascihealthsci.v26i2.1582

    Directory of Open Access Journals (Sweden)

    Maria Dalva de Barros Carvalho

    2004-04-01

    Full Text Available O objetivo deste estudo foi verificar o conhecimento que as mulheres têm sobre o exame preventivo do câncer cérvico-uterino, sua importância e os sentimentos delas em relação ao exame, em uma tentativa de melhor compreender a prática da prevenção. Trata-se de estudo descritivo exploratório. As mulheres demonstraram que, em relação ao exame, o medo e a vergonha são os maiores sentimentos. Em relação à importância do exame, a maioria relatou ser a prevenção e a descoberta precoce da doença o fator mais importante. Sobre o conhecimento da doença, relataram ter ouvido falar, visto na TV, mas o medo da doença e até do nome câncer é maior que a necessidade de realizar o exame.O que impede a realização do exame é o medo do resultado e a falta de tempo. Os dados permitiram concluir que é necessário aumentar a cobertura dos exames; orientar as mulheres através de campanhas e, ainda, desmistificar a técnica e os resultados dos mesmos.The aim of this work was to verify women’s knowledge of cervical uterine cancer prevention exam, its importance and women’s feelings towards it. This was done in order to better understand the prevention practice. This is an exploratory descriptive study. The women’s major feelings towards this exam are fear and shame. Regarding this exam importance, most of them said that the prevention and the precocious discovery of the illness are the most important factors. Knowledge of the disease was acquired through conversations and TV programs, even though fear of the disease is greater than the need to undertake the exams. The latter is impaired by fear regarding their result and by lack of time to undertake them. Data show that exam coverage should be broadened; more orientation should be given through campaigns; technique and exam results should be demystified.

  7. A rare case of minimal deviation adenocarcinoma of the uterine cervix in a renal transplant recipient.

    LENUS (Irish Health Repository)

    Fanning, D M

    2009-02-03

    INTRODUCTION: We report the first described case of minimal deviation adenocarcinoma of the uterine cervix in the setting of a female renal cadaveric transplant recipient. MATERIALS AND METHODS: A retrospective review of this clinical case was performed. CONCLUSION: This rare cancer represents only about 1% of all cervical adenocarcinoma.

  8. A rare case of minimal deviation adenocarcinoma of the uterine cervix in a renal transplant recipient.

    LENUS (Irish Health Repository)

    Fanning, D M

    2012-02-01

    INTRODUCTION: We report the first described case of minimal deviation adenocarcinoma of the uterine cervix in the setting of a female renal cadaveric transplant recipient. MATERIALS AND METHODS: A retrospective review of this clinical case was performed. CONCLUSION: This rare cancer represents only about 1% of all cervical adenocarcinoma.

  9. Mucoepidermoid Carcinoma of Uterine Cervix: A Distinct Pathological and Clinical Entity.

    Science.gov (United States)

    Selcuk, Ilker; Ozdal, Bulent; Turker, Mengu; Usubutun, Alp; Gungor, Tayfun; Meydanli, Mehmet Mutlu

    2015-01-01

    Mucoepidermoid carcinoma of uterine cervix is a rare tumor that has some individual features. Defining risk factors after surgery shape the postoperative treatment modality on cervical cancer patients. Although there is not a well-known strategy for the postoperative follow-up of mucoepidermoid carcinoma, the aggressive behaviour of this tumor makes the gynecological oncologists choose liberal therapies on these patients. PMID:26064727

  10. Radiculopatía cervical

    Scientific Electronic Library Online (English)

    Adriana, Murillo Calderón.

    2012-09-01

    Full Text Available La patología cervical traumática y su relación con el quehacer de la medicina legal tiene gran importancia y vigencia, principalmente cuando se hace necesario realizar valoraciones a pacientes con alteraciones cervicales y se debe definir si estas están en relación a un trauma determinado o repetiti [...] vo en el tiempo como puede ocurrir en algunos casos de riesgos de trabajo. El médico forense debe estar muy bien preparado, conocer la anatomía cervical y de los miembros superiores, realizar un interrogatorio y un examen físico neurológico exhaustivo para orientar las posibilidades diagnósticas; es fundamental además el análisis de los estudios diagnósticos. En este caso en particular se realizará una revisión de la radiculopatía cervical, su fisiopatología, mecanismos de producción y las implicaciones médico legales al realizar la valoración en pacientes con cervicobraquialgia Abstract in english Traumatic cervical pathology and its relationship to the work of forensic medicine is of great importance and relevance, especially when it is necessary to make assessments in patients with cervical changes and must be defined if they are in relation to a specific trauma or repetitive in time as may [...] occur in some cases of occupational hazards. The medical examiner must be very well prepared, know the anatomy of the cervical and upper limbs, perform an examination and a thorough neurological physical examination to guide the diagnostic possibilities, it is also fundamental analysis of diagnostic studies. In this particular case there will be a review of cervical radiculopathy, pathophysiology, mechanisms of production and the medico-legal implications when doing the assessment in patients with cervical braquial pain

  11. Can we rely on cancer mortality data? Checking the validity of cervical cancer mortality data for Slovenia

    International Nuclear Information System (INIS)

    Background. Valid inference on cervical cancer mortality is very difficult since - on the basis of death certificates - it is not always possible to distinguish between cervix, corpus and unspecified uterine cancer deaths. Our aim was to estimate the extent to which cervical cancer as the official cause of death reflects the true mortality from cervical cancer in Slovenia. Material and methods. The data on 2245 deaths from cervix, corpus uteri, and uterus-unspecified cancers for the period 1985-1999 were linked to the Cancer Registry of Slovenia database from the mortality database of Slovenia. Results. Officially, in the period 1985-1999, there were 878 cervical cancer deaths. The comparison of these causes of death with the cancer sites registered in the Cancer Registry revealed that they include only 87.7% patients with a previous diagnosis of cervical cancer. Of 650 corpus uteri cancer deaths, 17. 1 % of patients were registered to have cervical cancer, and of 717 unspecified uterine cancer deaths, 31.4% were registered. Taking into account the correctly identified cervical cancer cases among cervical cancer deaths and misclassified cervical cancer deaths as corpus uteri and unspecified uterine, the corrected number of deaths would be 1106. Conclusions. When evaluating the impact of cervical cancer mortality from national mortality rates, the stated underestimation should be taken into account. However, this does not hold for some other cancers. (author)for some other cancers. (author)

  12. Prolactin and prolactin receptor expression in cervical intraepithelial neoplasia and cancer.

    Science.gov (United States)

    Ascencio-Cedillo, Rafael; López-Pulido, Edgar Ivan; Muñoz-Valle, José Francisco; Villegas-Sepúlveda, Nicolás; Del Toro-Arreola, Susana; Estrada-Chávez, Ciro; Daneri-Navarro, Adrian; Franco-Topete, Ramón; Pérez-Montiel, Delia; García-Carrancá, Alejandro; Pereira-Suárez, Ana Laura

    2015-04-01

    Prolactin receptor (PRLR) overexpression could play a role in tumorigenesis. The aim of this study was to determine prolactin (PRL) and PRLR expression in biopsies from patients with precursor lesions and uterine cervical cancer. PRLR expression was analyzed in 63 paraffin-embedded biopsies of uterine cervical tissue. In total, eleven low-grade squamous intraepithelial lesions (LSIL), 23 high-grade squamous intraepithelial lesions (HSIL), 21 uterine cervical cancers (UCC) and 8 normal epithelium (NE) were examined using immunoperoxidase staining and Western blot analysis. Additionally, PRL expression was identified in human cervical cancer serum and tissues. The PRLR expression was found to be significantly increased in cervical cancer in comparison with normal tissue and precursor lesions (P?cervical cancer tissues. Serum PRL levels were normal in all samples and local prolactin expression was similar in precursor lesions and cervical cancer by Western blot analysis. Our data suggest a possible role for PRLR in the progression of cervical cancer. PMID:24990775

  13. Surgical Methods for the Treatment of Uterine Fibroids – Risk of Uterine Sarcoma and Problems of Morcellation: Position Paper of the DGGG

    Science.gov (United States)

    Beckmann, M. W.; Juhasz-Böss, I.; Denschlag, D.; Gaß, P.; Dimpfl, T.; Harter, P.; Mallmann, P.; Renner, S. P.; Rimbach, S.; Runnebaum, I.; Untch, M.; Brucker, S. Y.; Wallwiener, D.

    2015-01-01

    The appropriate surgical technique to treat patients with uterine fibroids is still a matter of debate as is the potential risk of incorrect treatment if histological examination detects a uterine sarcoma instead of uterine fibroids. The published epidemiology for uterine sarcoma is set against the incidence of accidental findings during surgery for uterine fibroids. International comments on this topic are discussed and are incorporated into the assessment by the German Society for Gynecology and Obstetrics (DGGG). The ICD-O-3 version of 2003 was used for the anatomical and topographical coding of uterine sarcomas, and the “Operations- und Prozedurenschlüssel” (OPS) 2014, the German standard for process codes and interventions, was used to determine surgical extirpation methods. Categorical qualifiers were defined to analyze the data provided by the Robert Koch Institute (RKI), the German Federal Bureau of Statistics (DESTATIS; Hospital and Causes of Death Statistics), the population-based Cancer Register of Bavaria. A systematic search was done of the MEDLINE database and the Cochrane collaboration, covering the period from 1966 until November 2014. The incidence of uterine sarcoma and uterine fibroids in uterine surgery was compared to the literature and with the different registries. The incidence of uterine sarcoma in 2010, standardized for age, was 1.53 for Bavaria, or 1.30 for every 100?000 women, respectively, averaged for the years 2002–2011, and 1.30 for every 100?000 women in Germany. The mean incidence collated from various surveys was 2.02 for every 100?000 women (0.35–7.02; standard deviation 2.01). The numbers of inpatient surgical procedures such as myoma enucleation, morcellation, hysterectomy or cervical stump removal to treat the indication “uterine myoma” have steadily declined in Germany across all age groups (an absolute decrease of 17?% in 2012 compared to 2007). There has been a shift in the preferred method of surgical access from an abdominal/vaginal approach to endoscopic or endoscopically assisted procedures to treat uterine fibroids, with the use of morcellation increasing by almost 11?000 coded procedures in 2012. Based on international statements (AAGL, ACOG, ESGE, FDA, SGO) on the risk of uterine sarcoma as an coincidental finding during uterine fibroid surgery and the associated risk of a deterioration of prognosis (in the case of morcellation procedures), this overview presents the opinion of the DGGG in the form of four Statements, five Recommendation and four Demands. PMID:25797958

  14. Fatores de risco para câncer de colo do útero segundo resultados de IVA, citologia e cervicografia Factores de riesgo para cáncer de cuello uterino según resultados de IVA, citología y cervicografía Risk factors for uterine cervical cancer according to results of VIA, cytology and cervicography

    Directory of Open Access Journals (Sweden)

    Saiwori de Jesus Silva Bezerra dos Anjos

    2010-12-01

    Full Text Available Este estudo objetivou avaliar a associação entre fatores de risco para câncer de colo do útero e lesões cervicais por HPV comparando-se os resultados da inspeção visual com o ácido acético (IVA, a citologia e a cervicografia. Realizou-se pesquisa de prevalência com 157 mulheres de um centro de saúde de Fortaleza, no período de junho a setembro de 2006. Utilizou-se o SPSS para codificar os dados. Realizaram-se inferências por meio de testes estatísticos (?2= quiquadrado e RV= razão de verossimilhança. IVA, cervicografia e citologia obtiveram 43,3%, 10,19% e 3,2% de resultados alterados, respectivamente. As variáveis com importante associação às lesões cervicais na IVA foram: idade menor de 20 anos (p= 0,0001; um ou mais parceiros nos últimos três meses (p= 0,015; uso de contraceptivos (p= 0,0008; presença de corrimento vaginal (p= 0,0001; e processo inflamatório moderado ou acentuado (p= 0,0001. Na citologia: baixa escolaridade (p= 0,0001 e elevado pH (p= 0,001. Não se encontrou associação significante na cervicografia.Este estudio objetivó evaluar la asociación entre factores de riesgo para cáncer de cuello de útero y lesiones cervicales por HPV, según comparación entre los resultados de la inspección visual con ácido acético (IVA, citología y cervicografía. Se realizó investigación de prevalencia, con 157 mujeres en un centro de salud de Fortaleza-CE-Brasil, en el período de junio a setiembre de 2006. Se utilizó el SPSS para codificar los datos. Se realizaron inferencias a través de tests estadísticos (?2 = Qui-cuadrado y RV= razón de verosimilitud. La IVA, cervicografía y citología obtuvieron 43,3%, 10,19% y 3,2% de resultados alterados. Las variables con importante asociación a lesiones cervicales en la IVA fueron: edad menor a 20 años (p=0,0001, uno o más parejas en los últimos tres meses (p=0,015, uso de anti-conceptivos (p=0,0008, presencia de vaginitis (p=0,0001 y pH elevado (p=0,001. No se encontró asociación significativa en la cervicografía.This study aimed to evaluate the association between risk factors for uterine cervical neoplasms and cervical lesions by HPV by comparison of the visual inspection with acetic acid (VIA, cytology and cervicography results. A prevalence research was made with 157 women in a health center of Fortaleza in the period of June to September 2006. The SPSS program was used to codify the data. Inferences were made through statistical tests (?2= chi square and LR= likelihood ratio. The VIA, cervicography and cytology obtained 43.3%, 10.19% and 3.2% of altered results. The variables with important association to cervical lesions in the VIA were: aged less than 20 years old (p= 0.0001; one or more partners in the last three months (p= 0.015; use of contraceptives (p = 0.0008; presence of vaginal discharge (p= 0.0001 and moderate or accentuated inflammatory process (p= 0.0001. In the cytology: low instructional level (p= 0.0001 and high pH (p= 0.001. It wasn't found any significant association in the cervicography.

  15. Incidencia y tendencia de lesiones cervicouterinas en mujeres pinareñas de 10-24 años. 2003-2012 / Incidence and tendency of cervical-uterine lesions in Pinar del Río 10-to-14-year-old women, 2003-2012

    Scientific Electronic Library Online (English)

    José Guillermo, Sanabria Negrín; Victor Enrique, Salgueiro Medina; Magalys Brígida, Abreu Mérida; Agustín, Lemus Sarracino; Raydel, Marrero Fernández.

    2014-02-01

    Full Text Available Introducción: se han detectado lesiones premalignas y malignas en mujeres menores de 25 años, pero no se conoce exactamente la magnitud del problema en Pinar del Río. Objetivo: evaluar la incidencia y la tendencia de lesiones premalignas y malignas del cuello uterino en mujeres pinareñas menores de [...] 25 años según características demográficas en el período 2003-2012. Material y método: se realizó un estudio retrospectivo, longitudinal para conocer la incidencia anual de lesiones premalignas y malignas del cuello uterino en mujeres pinareñas menores de 25 años. La muestra estuvo conformada por el resultado de las biopsias realizadas a estas jóvenes en ese período. Resultados: la incidencia anual por 10000 mujeres 10-24 años fue de 8.8 para las NIC I; 3,1 en NIC II; 1,6 para las NIC III + CIS, 0.07 para el microinvasor, 0.03 para el invasor Ib y 0.02 para el invasor estadio II. No se detectaron ni estadios superiores de la variedad epidermoide y adenocarcinomas endocervicales. La incidencia anual para cada una de las lesiones mostró una tendencia al incremento sobre todo para las NIC I. De 1198 biopsias realizadas en este grupo etario solamente se detectaron 7 carcinomas epidermoides invasores cervicales en 10 años, 0.7 anuales, con tasa de 5.8 x cada 1000 mujeres de 10-24 años. Conclusiones: la incidencia detectada de lesiones malignas en este grupo no justificaría comenzar la realización del pesquisaje citológico antes de los 25 años, ya que el costo sería alto y el beneficio mínimo. Abstract in english Introduction: malignant and pre-malignant lesions have been localized in women less than 25 years, but the exact enormity of the problem in Pinar del Río is not known. Objective: to evaluate the tendency and incidence of malignant and pre-malign cervical lesions in Pinar women less than 25 years old [...] according to demographic characteristics, in the period 2003-2012. Material and method: a retrospective, cross-sectional study was carried out, in order to know the annual incidence of malign and pre-malign cervical lesions in Pinar women younger than 25 years. The sample comprised the results of biopsies made of those women in that period. Results: the annual incidence in 10,000 women from 10-24 years old was 8.8 for CIN1, 3.1 for CIN2, 1.6 for CIN3 + CIS (carcinoma in situ), 0.07 for de micro-invasive, 0.03 for the invasive Ib, and 0.02 for the invasive stage II. Stages over neither epidermoidal nor endocervical adenocarcinomas were detected. The annual incidence in each lesion proved increasing particularly for NIC1 cases. Out of 1,198 biopsies made on this age group, only 10 invasive epidermoidal carcinomas were detected in ten years, 0.7 annually, with a proportion of 5.8 per 1,000 women between 10-24 years of age. Conclusions: The tendency of malignant lesions detected in this group would not justify starting the cytological screening before the 25 years of age, since the cost would high and the benefit would be minimal.

  16. Evidence for benefits from treating cervical ectopy: literature review / Evidências de benefícios no tratamento de ectopia do colo do útero: revisão de literatura

    Scientific Electronic Library Online (English)

    Luís Carlos, Machado Junior; Ana Sílvia Whitaker, Dalmaso; Heráclito Barbosa de, Carvalho.

    2008-03-01

    Full Text Available CONTEXTO E OBJETIVO: A ectopia do colo do útero é hoje considerada um fenômeno fisiológico, mas parece ainda haver uma forte tendência no sentido da intervenção (tratamento). Este estudo se propõe a realizar revisão da literatura buscando evidências de benefícios conseqüentes ao tratamento da ectopi [...] a. MÉTODOS: Pesquisa nas bases Medical Literature Analysis and Retrieval Sysem Online (Medline), Excerpta Medica Database (Embase), Literatura Latino-Americane e do Caribe em Ciências da Saúde (Lilacs), Biblioteca Cochrane e seis livros especializados. RESULTADOS: A revisão mostrou que: 1) existe provavelmente associação de ectopia com infecção cervical por Chlamydia trachomatis, pelo vírus HPV e maior risco de soroconversão para HIV; 2) existe provavelmente associação entre ectopia e neoplasia intra-epitelial cervical; 3) existe associação com mucorréia e nictúria; 4) não existem evidências sobre associação entre ectopia e câncer de colo do útero nem sobre proteção contra este câncer proporcionada pelo tratamento da ectopia. CONCLUSÕES: 1) Não foram encontrados na literatura dados que justifiquem o tratamento rotineiro da ectopia; 2) O tratamento pode ser utilizado para tratar sintomas associados à ectopia, porém mais sintomas são atribuídos à ectopia do que se pôde confirmar em um estudo controlado; 3) Seriam necessários novos estudos para testar a hipótese de proteção contra o câncer de colo proporcionada pelo tratamento. Abstract in english CONTEXT AND PURPOSE: Uterine cervical ectopy (cervical erosion) is today considered to be a physiological condition, but there still seems to be a strong tendency towards treating it. The purpose of this study was to review the medical literature for evidence regarding benefits from treating cervica [...] l ectopy. METHODS: The following databases were reviewed: Medical Literature Analysis and Retrieval System Online (Medline), Excerpta Medica Database (Embase), Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) and Cochrane Library databases. In addition, six medical textbooks were consulted. RESULTS: The review showed that: 1) there is probably an association between ectopy and higher risk of Chlamydia trachomatis, human papillomavirus and human immunodeficiency virus infection; 4) there is probably an association between ectopy and cervical intraepithelial neoplasia; 5) there is an association between ectopy and mucous discharge and nocturia; and 6) there is no evidence of an association between ectopy and cervical cancer, or of protection against cervical cancer associated with ectopy treatment. CONCLUSIONS: 1) No data were found in the medical literature to support routine treatment for ectopy; 2) Treatment could be recommended for symptom relief, but more symptoms are attributed to ectopy than could be demonstrated in a controlled study; 3) Further studies to test the hypothesis of protection against cervical cancer associated with treatment are necessary.

  17. Uterine Fibroid Embolization

    Medline Plus

    Full Text Available ... part, the patient's out bed the same day, home the next day, back to work in a week, okay. OR Live bah 2777 show 5 If we come back to our chart here, I want to just show you again schematically what Dr. Powell is doing next door. So, he's got his catheter way down in the uterine artery. And these ...

  18. Cervical Cancer – A Review Article

    Directory of Open Access Journals (Sweden)

    Gunjan Jadon

    2012-07-01

    Full Text Available Cervical Cancer is malignant Carcinoma type of cancer originate in cervix region. The cervix is the narrow portion of the uterus where it joins with the top of the vagina. Most cervical cancers are squamous cell carcinomas, arising in the squamous (flattened epithelial cells that line the cervix. Adenocarcinoma, arising in glandular epithelial cells is the second most common type. Very rarely, cancer can arise in other types of cells in the cervix. Cancer refers to a class of diseases in which a cell or a group of cells divide and replicate uncontrollably, intrude into adjacent cells and tissues (invasion and ultimately spread to other parts of the body than the location at which they arose (metastasis (National Cancer Institute 2009. In cervical cancer, (cancer of the uterine cervix, cancer develops in the tissues of the cervix, which is a part of the female reproductive system. The cervix connects the upper body of the uterus to the vagina. The endocervix (the upper part which is close to the uterus is covered by glandular cells, and the ectocervix (the lower part which is close to the vagina is covered by squamous cells. The transformation zone refers to the place where these two regions of the cervix meet (American Cancer Society 2009.

  19. Staging of carcinoma of the uterine cervix and endometrium

    International Nuclear Information System (INIS)

    Carcinoma of the uterine cervix and endometrium are common gynecologic malignancies. Both carcinomas are staged and managed by means of the International Federation of Gynecology and Obstetrics (FIGO) staging system. In uterine cervical cancer, the FIGO staging system is determined preoperatively by limited conventional procedures. Although this system is effective for early stage disease, it has inherent inaccuracies in advanced stage diseases and does not address nodal involvement. CT and MR imaging are widely used as comprehensive imaging modalities to evaluate tumor size and extent, and nodal involvement. MR imaging is an excellent modality for depicting invasive cervical carcinoma and can provide objective measurement of tumor volume, and provides high negative predictive value for parametrial invasion and stage IVA disease. In contrast, endometrial cancer is surgically staged. Beside recognition of the important prognostic factors, including histologic subtype and grade, accurate assessment of the tumor extent on preoperative MR imaging is expected to greatly optimize surgical procedure and therapeutic strategy. Contrast-enhanced MR imaging can offer ''one stop'' examination for evaluating the depth of myometrial invasion cervical invasion and nodal metastases. Evaluation of myometrial invasion on MR imaging may be an alternative to gross inspection of the uterus during the surgery. (orig.)

  20. Splenic Metastasis of Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature

    OpenAIRE

    Shigeki Taga; Mari Sawada; Aya Nagai; Dan Yamamoto; Ryoji Hayase

    2014-01-01

    Metastasis from various neoplasms to the spleen is very rare and most of the cases are found at autopsy. We report a patient presenting with uterine cervical cancer with splenic metastases. A 49-year-old woman presenting with genital bleeding was referred to our hospital and diagnosed with stage IIB cervical cancer. She underwent concomitant chemoradiotherapy (CCRT) consisting of 50?Gy whole pelvis irradiation, high-dose-rate intracavitary brachytherapy 24?Gy/4 fractions and six weeks of ...

  1. Transient Occlusion of Uterine Arteries in Laparoscopic Uterine Surgery

    Science.gov (United States)

    Kwon, Yong-Soon; Roh, Hyun Jin; Ahn, Jun Woo; Lee, Sang-Hun

    2015-01-01

    Background and Objectives: This study was conducted to determine the feasibility and effectiveness of transient occlusion of the uterine arteries (TOUA) during laparoscopic surgery for benign uterine tumors, with preservation of fertility. Methods: Patients with uterine myoma or adenomyoma underwent laparoscopic uterine surgery, with or without TOUA, performed by a single surgeon (Y.-S.K.). Surgical outcomes included operative time; occurrence of intraoperative injury of blood vessels, nerves, and pelvic organs; and intraoperative blood loss. Results: Of the 168 surgical patients included in this study, 144 were enrolled consecutively during the study period, and 24 had undergone adenomectomy before the study period. A total of 104 women (70 with myoma; 34 with adenomyoma) seeking uterine preservation underwent laparoscopic surgery with TOUA for benign uterine tumors. Sixty-four women (40 with myoma; 24 with adenomyoma) underwent surgery without TOUA. The mean total surgical time of the TOUA groups was 74.85 minutes for uterine myoma and 84.09 minutes for uterine adenomyoma. The mean estimated blood loss during laparoscopic myomectomy and adenomyomectomy was less in the TOUA groups than in the non-TOUA groups (109 vs. 203.4 mL in myomectomy, P < .05; 148.1 vs. 158.9 mL in adenomyomectomy; P < .05). Time to perform TOUA was 13.9 minutes in laparoscopic myomectomy and 7.33 minutes in laparoscopic adenomyomectomy. The hospital stay of the TOUA groups was 3.32 days for uterine myoma and 3.82 days for uterine adenomyoma. No intraoperative conversion to laparotomy was necessary, and no major complications occurred during any of the procedures. Conclusion: Laparoscopic uterine surgery with TOUA could be a safe and effective surgical method for women with symptomatic benign uterine tumors who wish to preserve fertility. PMID:25848179

  2. Low-cost technology for screening uterine cervical cancer / Technique peu coûteuse de dépistage du cancer du col utérin / Tecnología de bajo costo para el cribado del cáncer cervicouterino

    Scientific Electronic Library Online (English)

    Aditya, Parashari; Veena, Singh; Ashok, Sehgal; Labani, Satyanarayana; Pushpa, Sodhani; Madan M., Gupta.

    2000-08-01

    Full Text Available El cáncer cervicouterino es el tumor maligno más frecuente entre las mujeres de la India. En los países en desarrollo no es posible emprender programas de cribado citológico de ámbito nacional debido a la escasez de personal adiestrado y a la falta de la infraestructura necesaria. La simple inspecci [...] ón visual del cuello uterino detecta los cánceres tempranos con una menor sensibilidad y especificidad que los estudios citológicos. En nuestros estudios anteriores hallamos una tasa de detección relativamente baja de las lesiones cervicouterinas precancerosas. A raíz de ello desarrollamos el Magnivisualizador, un dispositivo de iluminación y aumento cuyo precio es de Rs 1500 (US$ 36). Pretendíamos así mejorar la sensibilidad de la inspección visual simple en la detección de lesiones precancerosas o indicativas de cáncer temprano.De fácil manejo, este instrumento portátil funciona con una pila recargable de 12 V. Consiste en una cámara de luz con un reflector en un lado y un condensador en el otro, equipada con una bombilla halógena de 12 V y 50 W. La cámara tiene en la parte superior, en el extremo del condensador, un cristal de aumento de 2,5 dioptrías y 100 mm de diámetro. Los resultados de la inspección visual simple realizada mediante el Magnivisualizador fueron comparados con los de la colposcopia y/o los informes histológicos en una muestra de 402 mujeres. En total se diagnosticaron histológicamente 73 displasias leves, 76 displasias avanzadas y 59 carcinomas in situ o cánceres invasivos en sus primeras fases. En el caso de las displasias leves, la sensibilidad del análisis citológico fue del 75,3%, y la del Magnivisualizador, del 57,5%. En lo que atañe a las displasias graves y los carcinomas in situ o los cánceres invasivos tempranos, en cambio, la sensibilidad fue del 94,9% con los dos métodos. La tasa de falsos positivos fue del 1,0% en los estudios citológicos, frente al 5,7% con el Magnivisualizador. La especificidad del cribado alcanzó el 94,3% con este último, y el 99% en el análisis citológico.El Magnivisualizador aumentó considerablemente la sensibilidad conseguida mediante la inspección visual simple, no sólo en la detección de carcinomas in situ o de cánceres invasivos tempranos, sino también en el caso de las lesiones precancerosas. Su sensibilidad en la detección de las displasias avanzadas y las lesiones más graves precitadas fue comparable a la del análisis citológico, y disminuyó la tasa de falsos positivos. Además, el costo del examen con Magnivisualizador fue de US$ 0,55, mientras que el del análisis citológico fue de US$ 1,10. La sencilla inspección visual que permite el dispositivo puede realizarse incluso en un centro de atención primaria, sin más requisito que una mesa de exploración Abstract in english We report on an illuminated, low-cost (Rs 1500 (US$ 36)) magnifying device (Magnivisualizer) for detecting precancerous lesions of the uterine cervix. A total of 403 women attending a maternal and child health care clinic who had abnormal vaginal discharge and related symptoms were referred for deta [...] iled pelvic examination and visual inspection by means of the device after the application of 5% (v/v) acetic acid. Pap smears were obtained at the same time. The results were compared with those obtained using colposcopy and/or histology. The Magnivisualizer improved the detection rate of early cancerous lesions from 60%, for unaided visual inspection, to 95%. It also permitted detection of 58% of cases of low-grade dysplasia and 83% of cases of high-grade dysplasia; none of these cases were detectable by unaided visual inspection. For low-grade dysplasia the sensitivity of detection by means of the Magnivisualizer was 57.5%, in contrast with 75.3% for cytological examination. However, the two methodologies had similar sensitivities for higher grades of lesions. The specificity of screening with the Magnivisualizer was 94.3%, while that of cytology was 99%. The cost per screening was approximately US$ 0.55 for the M

  3. Should helical tomotherapy replace brachytherapy for cervical cancer? Case report

    Directory of Open Access Journals (Sweden)

    Chen Yu-Jen

    2010-11-01

    Full Text Available Abstract Background Stereotactic body radiation therapy (SBRT administered via a helical tomotherapy (HT system is an effective modality for treating lung cancer and metastatic liver tumors. Whether SBRT delivered via HT is a feasible alternative to brachytherapy in treatment of locally advanced cervical cancer in patients with unusual anatomic configurations of the uterus has never been studied. Case Presentation A 46-year-old woman presented with an 8-month history of abnormal vaginal bleeding. Biopsy revealed squamous cell carcinoma of the cervix. Magnetic resonance imaging (MRI showed a cervical tumor with direct invasion of the right parametrium, bilateral hydronephrosis, and multiple uterine myomas. International Federation of Gynecology and Obstetrics (FIGO stage IIIB cervical cancer was diagnosed. Concurrent chemoradiation therapy (CCRT followed by SBRT delivered via HT was administered instead of brachytherapy because of the presence of multiple uterine myomas with bleeding tendency. Total abdominal hysterectomy was performed after 6 weeks of treatment because of the presence of multiple uterine myomas. Neither pelvic MRI nor results of histopathologic examination at X-month follow-up showed evidence of tumor recurrence. Only grade 1 nausea and vomiting during treatment were noted. Lower gastrointestinal bleeding was noted at 14-month follow-up. No fistula formation and no evidence of haematological, gastrointestinal or genitourinary toxicities were noted on the most recent follow-up. Conclusions CCRT followed by SBRT appears to be an effective and safe modality for treatment of cervical cancer. Larger-scale studies are warranted.

  4. Caracterização da demanda de pacientes com carcinoma de colo uterino no Hospital das Clínicas da Universidade Federal de Uberlândia, Minas Gerais, Brasil, 1984-1988 / Characterization of uterine cervical carcinoma cases in the Hospital das Clínicas, Universidade Federal de Uberlândia, Minas Gerais, Brazil, from 1984 to 1988

    Scientific Electronic Library Online (English)

    Eliane Regina, Pioli; Neide M. de, Oliveira; Alonso G. de, Rezende.

    1993-12-01

    Full Text Available Foi realizado um estudo retrospectivo de 180 casos de carcinoma de colo uterino internados no Hospital das Clínicas da Universidade Federal de Uberlândia, no período de 1984 a 1988, segundo variáveis pessoais e de tempo. Encontrou-se um aumento gradativo com o tempo e uma maior freqüência entre 35 e [...] 60 anos de idade. Aproximadamente 51% das pacientes eram provenientes de outras cidades e estados. Verificou-se uma maior freqüência em multíparas e em mulheres que iniciaram sua vida sexual antes dos 20 anos. Grande parte das mulheres (45%) ainda não tinha tido a menopausa. As manifestações clínicas mais freqüentes foram sangramento genital irregular e dor em baixo ventre. A citopatologia evidenciou Papanicolaou de graus III em 60,5% dos casos. A proporção de carcinoma in situ (20,6%) foi pequena em relação aos estágios mais avançados IIb (31,6%), Ib (14,5%), e IIIa, IIIb e IV (18,9%), os quais, havendo uma orientação mais sistematizada de prevenção, podem ser encontrados com menor freqüência. A relação carcinoma invasor/carcinoma in situ foi de 2,52 no período de 1984 a 1986, aumentando para 4,75 entre 1987 e 1988, o que indica não terem sido atingidos níveis satisfatórios de prevenção da doença na cidade e na região no período estudado. Abstract in english This is a retrospective survey of 180 cases of uterine cervical carcinoma in women admitted to the Hospital de Clínicas da Universidade Federal de Uberlândia, from 1984 to 1988, with regard to personal and temporal factors. There was a gradual increase in frequency over time and a greater frequency [...] among women from 35 to 60 years of age. Half of the women came from other cities and states. The conditions was more frequent in multiparous women and in women who initiated sexual intercourse before the age of 20. A major proportion of women (45.0 %) had not reached menopause. Genital bleeding and abdominal pain were the most frequent clinical manifestations. Cytopathological study revealed a percentage of 60.5 % of stages III and IV. There was a low frequency of in situ cancer (20.6 %), when compared to the frequency of more advanced stages (71.6 %). The proportion of advanced stages as compared to in situ cancer increased over time, which may indicate that an optimal level of prevention was far reality in this region during the study period.

  5. Uterine fibroid embolization

    International Nuclear Information System (INIS)

    Full text: Introduction: Today, after numerous lengthy randomized trials embolization of uterine fibroids has become a standard treatment. Percutaneous embolization of myomas is a micro - invasive surgery, which can be regarded as an alternative to traditional surgery. Although these data 2/3 of the patients were not informed about this treatment option. What you will learn: The uterine embolization is minimal invasive non-surgical procedure. It is an alternative treatment to surgery. Under local anesthesia in the femoral artery puncture reaches the internal iliac artery and uterine arteries. Reached selectively by the catheter and chemicals, which causes clogging, are injected into them. In the vessels that feed fibroids occur a process like an attack, the feeding stops, it starts to shrink and it is replaced by fibrous tissue. The blood vessels of the healthy tissue are different in size and have a plurality of collateral connections as opposed to those of the myoma and thus the blood supply to the normal tissue of the uterus is not distorted. Discussion: Nowadays there are more well- calibrated materials for embolization and those with a particle size of about 700µ are proven as the most successful. The procedure is well tolerated, but after a pain occurs, which has to be covered with anesthetics. Usually pain and metrorrhagia disappear immediately. The fibroids themselves shrink to varying degrees. Hospital stay was significantly shorter than that after surgery, and remained fertile power. Complications are few and rare require further treatment. Multiple nodes are problematic and it is difficult to detect the primary one. A three and six months tracking by MRI is desirable. Conclusion: Embolization of uterine myoma is an established method of treatment primarily on clinical symptoms resulting therefrom. In all patients rapidly disappear metrorrhagia symptoms and morbidity, the volume of the assembly decrease, which together with shorter hospital stays and fertility preservation is well accepted by patients and therefore it is a good alternative to surgery

  6. Uterine fibroids: current perspectives

    OpenAIRE

    At, Khan; Shehmar M; Jk, Gupta

    2014-01-01

    Aamir T Khan,1 Manjeet Shehmar,1 Janesh K Gupta21Birmingham Women's Hospital, Edgbaston, Birmingham, UK; 2Academic Department of Obstetrics and Gynaecology, University of Birmingham, Birmingham, UKAbstract: Uterine fibroids are a major cause of morbidity in women of a reproductive age (and sometimes even after menopause). There are several factors that are attributed to underlie the development and incidence of these common tumors, but this further corroborates their relatively unkno...

  7. Detection of Human Papillomavirus in Chronic Cervicitis, Cervical Adenocarcinoma, Intraepithelial Neoplasia and Squamus Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Elahe Mirzaie-Kashani

    2014-05-01

    Full Text Available Background: Cervical cancer is the second most common cancer in women worldwide. Recent studies show that human papillomavirus (HPV DNA is present in all cervical carcinomas and in some cervicitis cases, with some geographical variation in viral subtypes. Therefore determination of the presence of HPV in the general population of each region can help reveal the role of these viruses in tumors. Objectives: This study aimed to estimate the frequency of infection with HPV in cervicitis, cervical adenocarcinoma, intraepithelial neoplasia and squamus cell carcinoma samples from the Isfahan Province, Iran. Patients and Methods: One hundred and twenty two formalin fixed paraffin embedded tissue samples of crevicitis cases and different cervix tumors including cervical intraepithelial neoplasia (CIN (I, II, III, squamus cell carcinoma (SCC and adenocarcinoma were collected from histopathological files of Al-Zahra Hospital in Isfahan. Data about histopathological changes were collected by reexamination of the hematoxylin and eosin stained sections. DNA was extracted and subjected to Nested PCR using consensus primers, MY09/MY11 and GP5+/GP6+, designed for amplification of a conserved region of the genome coding for L1 protein. Results: In total 74.5% of the tested samples were positive for HPV. Amongst the tested tumors 8 out of 20 (40% of CIN (I, II, III, 5 out of 21 (23.8% of adenocarcinoma cases and 78 out of 79 chronic cervicitis cases were positive for HPV. Conclusions: The rate of different carcinomas and also the rate of HPV infection in each case were lower than other reports from different countries. This could be correlated with the social behavior of women in the area, where they mostly have only one partner throughout their life, and also the rate of smoking behavior of women in the studied population. On the other hand the rate of HPV infection in chronic cervicitis cases was much higher than cases reported by previous studies. This necessitates more attention to the role of human papillomaviruses in the their induction in the studied area. Keywords: Polymerase Chain Reaction; Uterine Cervical Neoplasms; Uterine Cervicitis

  8. [Radiotherapy for cervical cancer: a multi-institutional comparison].

    Science.gov (United States)

    Ito, H

    1999-11-01

    Radiotherapy has long been recognized as a successful treatment modality for all stages of carcinoma of the uterine cervix. In Japan, however, radiotherapists mainly have had to treat patients with far advanced cancer. Recently, however, the incidence of patients with early-stage cervical cancer who undergo surgery has increased, whereas that of patients with advanced disease has decreased significantly. As a result, the number of cervical cancer patients who visit radiotherapy departments has decreased significantly. Radiotherapy is useful for early cervical cancer, and radiotherapists need to make every effort to treat patients with early-stage cancer. Radiotherapy alone for cervical cancer consists mainly of external irradiation and intracavitary brachytherapy. Two modalities are used for brachytherapy, low dose rate and high dose rate. The latter modality, which was developed about three decades ago, spread rapidly and was improved in Japan and Europe. In 1983, the standard method of treating cervical cancer with Co-60 RALS was proposed by Arai et al. in Japan. Most institutes accepted this method with some modifications and have reported treatment results based on it. Currently, several modalities of radiotherapy are available for cervical cancer. JASTRO organized a study group to reconsider the treatment proposed by Arai et al. and reviewed the outcomes from nine institutions in Japan. Chemotherapy combined with radiotherapy previously was considered ineffective for cervical cancer. However, this February NCI suggested concomitant chemoradiotherapy was effective for improving the survival rates of most cervical cancer patients. This suggestion is introduced. PMID:10614104

  9. Surgical uterine drainage and lavage as treatment for canine pyometra

    Scientific Electronic Library Online (English)

    K G M, De Cramer.

    2010-09-01

    Full Text Available Pyometra is a common post-oestral syndrome in bitches. Classical treatment consists of either ovariohystorectomy or medical intervention. Surgical uterine drainage and lavage via direct trans-cervical catheterisation using a 5 % povidone-iodine in saline solution was performed successfully in 8 bitc [...] hes with pyometra. All bitches conceived and whelped without complications subsequent to this treatment. It is concluded that this method offers an effective alternative treatment for canine pyometra with shorter recovery times as well as good clinical recovery and pregnancy rates in bitches destined for further breeding.

  10. Cervical Spondylotic Myelopathy (CSM)

    Science.gov (United States)

    MENU Return to Web version Cervical Spondylotic Myelopathy Overview What is cervical spondylotic myelopathy? Cervical spondylotic myelopathy (CSM) is a compression of the spinal cord in the neck. (When ...

  11. MR features of isolated uterine relapse in an adolescent with acute lymphoblastic leukaemia

    Energy Technology Data Exchange (ETDEWEB)

    Novellas, Sebastien; Fournol, Maude; Geoffray, Anne; Chevallier, Patrick [Regional Hospital Centre and University of Nice, Medical Imaging Service, Archet 2 Hospital, 151 route de Saint Antoine de Ginestiere, B.P. 3079, Nice Cedex 3 (France); Deville, Anne [Regional Hospital Centre and University of Nice, Paediatric Service, Archet 2 Hospital, Nice (France); Kurzenne, Jean-Yves [Regional Hospital Centre and University of Nice, Paediatric Surgery Service, Archet 2 Hospital, Nice (France)

    2008-03-15

    Relapses of lymphoblastic leukaemia traditionally involve the central nervous system and testes in boys. Involvement of the female pelvic organs is frequently found at autopsy; however, involvement of the cervical uterus is rare and even less commonly symptomatic. A 13-cm uterine mass was discovered in a 15-year-old adolescent with a history of lymphoblastic leukaemia during childhood. Pelvic MRI was the best tool to assess the size, characteristics and invasive nature of this lesion of the uterine cervix. To our knowledge, this is a unique case in that we describe the MRI appearance of a relapsing lymphoblastic leukaemic mass both before and after treatment. (orig.)

  12. MR features of isolated uterine relapse in an adolescent with acute lymphoblastic leukaemia

    International Nuclear Information System (INIS)

    Relapses of lymphoblastic leukaemia traditionally involve the central nervous system and testes in boys. Involvement of the female pelvic organs is frequently found at autopsy; however, involvement of the cervical uterus is rare and even less commonly symptomatic. A 13-cm uterine mass was discovered in a 15-year-old adolescent with a history of lymphoblastic leukaemia during childhood. Pelvic MRI was the best tool to assess the size, characteristics and invasive nature of this lesion of the uterine cervix. To our knowledge, this is a unique case in that we describe the MRI appearance of a relapsing lymphoblastic leukaemic mass both before and after treatment. (orig.)

  13. [Cervical spondylosis].

    Science.gov (United States)

    Iwanami, Akio; Toyama, Yoshiaki

    2014-10-01

    Japan has now become an aging society. In 2014, people aged more than 65 years old accounted for 25.1% of Japan's entire population. Aging is associated with an increased risk of problems related to the locomotive organs. Deterioration of locomotive ability causes falls or tumbles, which would be a threat to good health and longevity of aged people. To maintain the locomotive ability of the elderly, therefore, the Japanese Orthopaedic Association starts a campaign to promote awareness and prevention of "locomotive syndrome". Cervical spondylosis is a disorder for age-related wear affecting the disks and vertebrae of cervical spine. It would also be a cause of "locomotive syndrome". Here, we give an outline of this disease and introduce its diagnosis and treatment. PMID:25509798

  14. Erosion sculptures

    Science.gov (United States)

    Ristroph, Leif; Moore, M. N. J.; Childress, Stephen; Shelley, Michael; Zhang, Jun

    2012-11-01

    Erosion by flowing fluids carves the striking landscapes imprinted on the Earth and on the surfaces of our neighboring worlds. In these processes, solid boundaries both influence and are shaped by the surrounding fluid, but the emergence of morphology as a result of this interaction is not well understood. We study the coevolution of shape and flow in the context of clay bodies immersed in fast flowing water. Although commonly viewed as a smoothing process, we discover that erosion sculpts surprisingly sharp points and corners that persist as the body shrinks. These features result from a natural tendency to form surfaces that erode uniformly, and we argue that this principle may also apply to the more complex scenarios that occur in nature.

  15. Morphoproteomic Evidence of Constitutively Activated and Overexpressed mTOR Pathway in Cervical Squamous Carcinoma and High Grade Squamous Intraepithelial Lesions

    OpenAIRE

    Feng, Wei; Duan, Xiuzhen; Liu, Jinsong; Xiao, Jianguo; Brown, Robert E.

    2008-01-01

    Human papilloma virus (HPV) infection of the uterine cervix is linked to the pathogenesis of cervical cancer. Preclinical in vitro and in vivo studies using HPV-containing human cervical carcinoma cell lines have shown that the mammalian target of rapamycin (mTOR) inhibitor, rapamycin, and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, erlotinib, can induce growth delay of xenografts. Activation of Akt and mTOR are also observed in cervical squamous cell carcinoma and, the...

  16. Neuroendocrine differentiation in a case of cervical cancer

    Directory of Open Access Journals (Sweden)

    Mona Mohamed Rashed

    2010-07-01

    Full Text Available Neuroendocrine neoplasms may occur in the uterine cervix, although rarely; it accounts for 0.5-1% of all malignant tumors of the uterine cervix. A case report of an Ethiopian female presented at the Gynecology Out-Patient Clinic at Jimma University Hospital, complaining from irregular vaginal bleeding over the previous three months. Clinically there was a cauliflower cervical mass; histopathologically it was formed of sheets of small cell tumor; that further showed neuroendocrine differentiation, as demonstrated by chromogranin-A positivity. It is important to differentiate small cell carcinoma from other malignant tumors of the uterine cervix. Morphological features play an important role in making a diagnosis and the immunohistochemistry study can offer an additional useful assistance

  17. Current Evidence on Uterine Embolization for Fibroids

    OpenAIRE

    Spies, James B.

    2013-01-01

    Strong evidence for both safety and effectiveness of uterine fibroid embolization has been generated since the procedure's introduction. This review will focus on the key articles representing the best evidence to summarize the outcomes from uterine embolization. This review will attempt to answer three important questions associated with uterine embolization. First, does uterine embolization relieve symptoms caused by uterine fibroids? Second, how well does the improvement in symptoms and qu...

  18. Induction of labor using double balloon cervical device in women with previous cesarean section: Experience and review

    OpenAIRE

    N. Nassif; E. Ebeid

    2013-01-01

    Induction of labour remains one of the most challenging interventions in current obstetrics. Different pharmaceuticals have been used for cervical ripening such as prostaglandins; however they can lead to a number of potential inconvenient risks namely uterine tachysystole and pathological fetal cardiotocography (CTG). In cases of women with previous caesarean births, using prostaglandins would pose even higher risks such as uterine rupture and perinatal mortality. A mechanical method of cer...

  19. Clinical efficiency investigation of laparoscopic uterine artery occlusion combined with myomectomy for uterine fibroids

    OpenAIRE

    Yin, Xiang-Hua; Gao, Ling-ling; Gu, Yang; Song, Jing-Zhe; Gao, Jing; Ji, Xiao-Ping

    2014-01-01

    To investigate the effectiveness of laparoscopic uterine artery occlusion combined with myomectomy for uterine fibroids. From August 2008 to August 2009, forty-eight women with uterine fibroids desiring to preserve their uteri underwent laparoscopic myomectomy. Among them, 18 women received laparoscopic uterine artery occlusion before uterine myomectomy while the others received laparoscopic myomectomy only. All of the 48 cases with uterine fibroids underwent laparoscopic myomectomy successfu...

  20. Immunologic treatments for precancerous lesions and uterine cervical cancer

    OpenAIRE

    Vici, Patrizia; Mariani, Luciano; Pizzuti, Laura; Sergi, Domenico; Di Lauro, Luigi; Vizza, Enrico; Tomao, Federica; Tomao, Silverio; Cavallotti, Claudia; Paolini, Francesca; Venuti, Aldo

    2014-01-01

    Development of HPV-associated cancers not only depends on efficient negative regulation of cell cycle control that supports the accumulation of genetic damage, but also relies on immune evasion that enable the virus to go undetected for long periods of time. In this way, HPV-related tumors usually present MHC class I down-regulation, impaired antigen-processing ability, avoidance of T-cell mediated killing, increased immunosuppression due to Treg infiltration and secrete immunosuppressive cyt...

  1. Integrative review of the nursing interventions used for the early detection of cervical uterine cancer / Revisión integradora de las intervenciones de enfermería utilizadas para detección precoz del cáncer cervicouterino / Revisão integrativa das intervenções de enfermagem utilizadas para detecção precoce do câncer cérvico-uterino

    Scientific Electronic Library Online (English)

    Camila Teixeira Moreira, Vasconcelos; Marta Maria Coelho, Damasceno; Francisca Elisângela Teixeira, Lima; Ana Karina Bezerra, Pinheiro.

    2011-04-01

    Full Text Available Em um programa nacional de combate ao câncer cérvico-uterino (CCU) devem existir quatro elementos básicos: prevenção primária, detecção precoce, diagnóstico/tratamento e cuidados paliativos. Desses, a detecção precoce é a modalidade mais efetiva. Um dos propósitos da Prática Baseada em Evidências é [...] encorajar a utilização de resultados de pesquisa junto à assistência prestada, reforçando a importância da pesquisa para a prática clínica. Esse estudo objetivou avaliar as evidências disponíveis na literatura sobre as intervenções de enfermagem eficazes na detecção precoce do CCU. A seleção dos artigos foi realizada nas bases: Scopus, PubMed, CINAHL, LILACS e Cochrane. A amostra desta revisão constitui-se de 7 artigos, com níveis de evidência 1, 2 ou 3. Tanto as intervenções comportamentais como as cognitivas e sociais mostraram efeitos positivos na detecção precoce do CCU, com destaque para as intervenções cognitivas interativas. Sugere-se, quando adequado, utilizar combinação das intervenções para se obter resultado mais eficaz. Abstract in spanish En un programa nacional de combate al cáncer cervicouterino (CCU) deben existir cuatro elementos básicos: prevención primaria, detección precoz, diagnóstico/tratamiento y cuidados paliativos. De estos, la detección precoz es la modalidad más efectiva. Uno de los propósitos de la Práctica Basada en E [...] videncias es incentivar la utilización de resultados de investigación junto a la asistencia prestada, reforzando la importancia de la investigación para la práctica clínica. Este estudio objetivó evaluar las evidencias disponibles en la literatura sobre las intervenciones de enfermería eficaces en la detección precoz del CCU. La selección de los artículos fue realizada en las bases: Scopus, Pubmed, CINAHL, LILACS y Cochrane. La muestra de esta revisión se constituye de 7 artículos, con niveles de evidencia 1, 2 o 3. Tanto las intervenciones comportamentales, como las cognitivas y sociales mostraron efectos positivos en la detección precoz del CCU, con destaque para las intervenciones cognitivas interactivas. Se sugiere, cuando adecuado, utilizar una combinación de las intervenciones para obtener un resultado más eficaz. Abstract in english In a national program to combat cervical uterine cancer (CUC) four basic elements should exist: primary prevention, early detection, diagnosis/treatment and palliative care. Of these, early detection is the most effective modality. One of the purposes of Evidence-Based Practice (EBP) is to encourage [...] the use of research results with the assistance provided, reinforcing the importance of research for clinical practice. This study aimed to evaluate the evidence available in the literature regarding effective nursing interventions for the early detection of CUC. The selection of articles was performed in the databases: Scopus, PubMed, CINAHL, Lilacs and Cochrane. The sample of this review consisted of seven articles, with evidence levels 1, 2 or 3. The behavioral, cognitive and social interventions, showed positive effects in the early detection of CUC, especially the interactive cognitive interventions. It is suggested, when appropriate, to use a combination of interventions in order to obtain a more effective result.

  2. Erosion protection

    International Nuclear Information System (INIS)

    All earth dams require protection against erosion due to wave action on the upstream slope and protection against runoff from rain, snowmelt or wave splash on the downstream shell. Erosion protection is a major cost factor in embankment dams, typically varying from 5-15% of the dam cost, although it can approach 50% of embankment cost for long low dikes. The most common type of erosion protection is dumped rock riprap. Current practice in riprap design is based on rational analysis of factors affecting riprap stability, and the performance of existing riprap protection. Historical development of riprap design is reviewed, beginning with U.S. Army Corps of Engineers dams in the 1940s. Riprap design parameters are based on slope steepness and severity of wave action, which depends on reservoir geometry and location. A common cause of riprap deterioration is loss of underlying bedding as a result of inadequate design or segregation of riprap and bedding during construction. The most common form of riprap failures include: loss of filter material through riprap if it is too fine; inadequate rock size to resist wave action, resulting in beaching; segregation during construction, resulting in pockets of undersized rock which can expose the underlying filter, and pockets of oversized rock through which bedding can wash out; breakdown of poor quality stone due to prolonged exposure and wave action; and failure to extend the primary riprap far enough downslope to be below the prap far enough downslope to be below the level of wave action at low reservoir levels. 26 refs., 8 figs

  3. Uterine Artery Anatomy Relevant to Uterine Leiomyomata Embolization

    International Nuclear Information System (INIS)

    To categorize the anatomic variants of uterine arteries, and determine the incidence of menopausal symptoms where the tubo-ovarian branches were seen prior to embolization. Between July 1997 and June 2000, 257 (n = 257) uterine fibroid embolizations were performed at our institution. Arteriograms were retrospectively evaluated. Uterine arteries were classified into groups: type I (the uterine artery as first branch of the inferior gluteal artery), type II (the uterine artery as second or third branch of the inferior gluteal artery), type III (the uterine artery, the inferior gluteal and the superior gluteal arteries arising as a trifurcation), type IV (the uterine artery as first branch of the hypogastric artery), inconclusive, or not studied. Tubo-ovarian branches were recorded if visualized prior to and/or after embolization. Menopausal symptoms were recorded (n = 175 at 3 months, n = 139 at 6 months, n = 98 at 1 year, n = 22 at 2 years) using written questionnaires. Five hundred and fourteen uterine arteries (n = 514) were evaluated. There were 38% classifiable types, 23% inconclusive, and 39% not studied. Classification was as follows: type I, 45%; type II, 6%; type III, 43%; type IV, 6%. Among 256 patients, tubo-ovarian arteries were seen in 36 prior to embolization, but not afterwards. In this group, 25 patients reported transient menopausal symptoms (hot flashes, amenorrhea). Five patients did not report any menopausal symptoms. Six patients did not answer the symptoms. Six patients did not answer the questionnaires. Type I is the most common type of anatomy, followed by type III. The tubo-ovarian arteries may be visualized prior to and/or after embolization. The embolization was monitored to avoid embolization of the tubo-ovarian branches. Menopausal symptoms were transient all patients when the tubo-ovarian branches were seen prior to embolization

  4. Implementation of hysteroscopy in an infertility clinic: The one-stop uterine diagnosis and treatment.

    Science.gov (United States)

    Campo, R; Meier, R; Dhont, N; Mestdagh, G; Ombelet, W

    2014-01-01

    Magnetic Resonant Imaging (MRI) has demonstrated that we can differentiate the uterus in 3 important functional areas. Exploration of the uterus in the infertile patient should implement the evaluation of the endometrium, the Junctional zone myometrium (JZ), the outer myometrium and the cervical canal. Especially the JZ myometrium should receive our close attention in the exploration and treatment of the infertile patient. MRI cannot be implemented as a screening examination but also limiting the imaging of the womb to a 2 or 3 D ultrasound exam only does not meet the scientific requirements of sensitivity and specificity. Modern ambulatory uterine diagnosis in a one-stop approach includes transvaginal ultrasound, fluid mini Hysteroscopy, contrast sonography and endomyometrial tissue sampling. Transvaginal Ultrasound being the gold standard for global uterine screening has a cardinal importance for diagnosis of myometrial disorders and uterine congenital malformations whereas hysteroscopy remains the gold standard for the evaluation of the endometrium and cervical canal. The major challenge remains to perform a tissue sampling of the endo-myometrium in an ambulatory, patient friendly and reliable way for which the newly designed Trophy hysteroscope provide a satisfactory answer. This one-stop approach opens a total new and advanced dimension to the screening, diagnosis and treatment of uterine pathology in the infertile patient. PMID:25593699

  5. Uterine arterial embolization for uterine leiomyoma: efficacy and clinical outcome

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jeong Seon; Lee, Do Yon; Kim, Yong Tae; Park, Ki Hyun; Park, Yong Won; Cho, Jae Sung; Kim, Myung Jun [Yonsei Univ. College of Medicine, Seoul (Korea, Republic of); Won, Je Hwan [Ajou Univ. College of Medicine, Suwon (Korea, Republic of); Kang, Byung Chul [Ewha Womans Univ. College of Medicine, Seoul (Korea, Republic of)

    1999-09-01

    To determine the efficacy and clinical outcome of uterine arterial embolization as a new approach to the management of uterine leiomyomas. Uterine arterial embolization was performed in 21 patients aged 26-62(mean, 42) years. Twenty of these had menorrhagia, dysmenorrhea, and mass-related symptoms (low abdominal discomfort, backache, urinary frequency, etc.) and one was diagnosed incidentally. Bilateral uterine arteries were selected individually and polyvinyl alcohol and/or gelfoam was used as an embolic material. Nineteen patients were followed up after embolization. Seventeen (89.5 %)reported satisfactory improvement of symptoms and follow-up sonography three months later showed a 58.5 % reduction in mean myoma volume. In 17 patients (89.5 %), the menstrual cycle returned to normal. All patients experienced pain after the procedure and other complications were vaginal bleeding (26.3 %) and fever (23.8 %). Uterine arterial embolization represents a new approach to the management of uterine leiomyoma-related symptoms. Further investigations and long-term follow-up are, however, enquired.

  6. Uterine arterial embolization for uterine leiomyoma: efficacy and clinical outcome

    International Nuclear Information System (INIS)

    To determine the efficacy and clinical outcome of uterine arterial embolization as a new approach to the management of uterine leiomyomas. Uterine arterial embolization was performed in 21 patients aged 26-62(mean, 42) years. Twenty of these had menorrhagia, dysmenorrhea, and mass-related symptoms (low abdominal discomfort, backache, urinary frequency, etc.) and one was diagnosed incidentally. Bilateral uterine arteries were selected individually and polyvinyl alcohol and/or gelfoam was used as an embolic material. Nineteen patients were followed up after embolization. Seventeen (89.5 %)reported satisfactory improvement of symptoms and follow-up sonography three months later showed a 58.5 % reduction in mean myoma volume. In 17 patients (89.5 %), the menstrual cycle returned to normal. All patients experienced pain after the procedure and other complications were vaginal bleeding (26.3 %) and fever (23.8 %). Uterine arterial embolization represents a new approach to the management of uterine leiomyoma-related symptoms. Further investigations and long-term follow-up are, however, enquired

  7. The relationship between pain and uterine contractions during laser vaporization of the cervix.

    Science.gov (United States)

    Julian, T M; O'Connell, B J; Gosewehr, J A

    1992-05-01

    Laser vaporization of the uterine cervix to treat cervical dysplasia is usually described by patients as moderately painful. Many describe the pain as uterine cramping, but most authorities attribute the pain to heat buildup during the procedure. To specify the mechanism of pain, intrauterine pressures were measured in 16 subjects (randomly divided into placebo and control groups of eight each) before and during cervical laser vaporization for dysplasia. The women were told what to expect during intrauterine pressure recording and laser vaporization and that a study of pain medication during laser vaporization was being conducted. The session began with 5 minutes of baseline intrauterine pressure recording. Subjects were then randomly given oral placebo or ibuprofen, 600 mg. Thirty to 45 minutes later, the intrauterine catheter was reinserted and the pressure recorded during 5 minutes of cervical laser vaporization. Laser vaporization increased significantly the frequency (P less than .025) and amplitude (P less than .03) of contractions in the placebo group but not in subjects given ibuprofen. However, post-procedure pain questionnaires showed no difference in pain perception between the groups. This study shows that pain during laser vaporization of the cervix is not due to increased uterine contractions, and that pain was not significantly relieved by ibuprofen. PMID:1565349

  8. Radiological appearances of uterine fibroids

    OpenAIRE

    Sue, Wilde; Sarah, Scott-barrett

    2009-01-01

    Uterine fibroids, also known as leiomyomas, are the commonest uterine neoplasms. Although benign, they can be associated with significant morbidity and are the commonest indication for hysterectomy. They are often discovered incidentally when performing imaging for other reasons. Usually first identified with USG, they can be further characterized with MRI. They are usually easily recognizable, but degenerate fibroids can have unusual appearances. In this article, we describe the appearances ...

  9. Medical Treatment of Uterine Leiomyoma

    OpenAIRE

    Sabry, Mohamed; Al-hendy, Ayman

    2012-01-01

    Uterine leiomyomas (also called myomata or fibroids) are the most common gynecologic tumors in the United States. The prevalence of leiomyomas is at least 3 to 4 times higher among African American women than in white women. Pathologically, uterine leiomyomas are benign tumors that arise in any part of the uterus under the influence of local growth factors and sex hormones, such as estrogen and progesterone. These common tumors cause significant morbidity for women and they are considered to ...

  10. Endometrial cancer with cervical extension mimicking dual concordant endometrial and cervical malignancy by F18 FDG PET and MRI

    International Nuclear Information System (INIS)

    A 35 year old woman with endometrial cancer and cervical extension underwent F18 FDG PET CT and MRI studies after resection of a cervical mass presumed to be cervical myoma. The patient underwent cervical myomectomy and the histopathologic report revealed poorly differentiated invasive carcinoma. Cervical cancer was ruled out because the patient had no history of sexual intercourse and was negative for human papilloma virus infection. The patient underwent radical hysterectomy, bilateral salpingo oophorectomy, pelvic and para aortic lymph node dissection, and multiple biopsies. F18 FDG PET CT showed intense FDG uptake along the cervix wall. T2 weighted MRI also revealed a mass lesion with high SI involving the anterior and posterior lips of the uterine cervix. Another area of focal increased uptake above the endometrial lesion in the left pelvic cavity was observed on PET CT and MRI, possibly due to a functioning ovary. PET CT and MRI were interpreted as showing a dual concordant malignant lesion due to separated FDG uptakes and high SI without any connection between the cervical and endometrial lesions. F18 FDG PET CT showed intense FDG uptake along the endometrium. Given the patient's history and the fact that she was not menstruating at the time of imaging, this intense uptake was interpreted as another pathologic lesion, suggesting dual primary lesions. A suspected heterogeneous mass lesion along the endometrium suggesting concordant endometrial cancer was found o concordant endometrial cancer was found on MRI. Endometrial cancer with cervical extension is sometimes difficult to differentiate from primary cervical cancer. The final histopathologic report showed poorly differentiated endometrial adenocarcinoma with cervical extension, although the FDG PET CT and MRI findings were suggestive of concordant cervical and endometrial cancer. Although histopathologic confirmation is necessary for final diagnosis, MRI and FDG PET CT studies may aid in the differential diagnosis. A metastatic cervical mass from endometrial cancer clinically presenting as cervical myoma is rare. This case suggests that poorly differentiated endometrial cancer may extend into the cervix, presenting as cervical myoma, and the possibility of a metastatic mass should be considered in the differential diagnosis when dealing with cervical myoma

  11. Endometrial cancer with cervical extension mimicking dual concordant endometrial and cervical malignancy by F18 FDG PET and MRI

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Seok Nam [Kwandong Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-09-15

    A 35 year old woman with endometrial cancer and cervical extension underwent F18 FDG PET CT and MRI studies after resection of a cervical mass presumed to be cervical myoma. The patient underwent cervical myomectomy and the histopathologic report revealed poorly differentiated invasive carcinoma. Cervical cancer was ruled out because the patient had no history of sexual intercourse and was negative for human papilloma virus infection. The patient underwent radical hysterectomy, bilateral salpingo oophorectomy, pelvic and para aortic lymph node dissection, and multiple biopsies. F18 FDG PET CT showed intense FDG uptake along the cervix wall. T2 weighted MRI also revealed a mass lesion with high SI involving the anterior and posterior lips of the uterine cervix. Another area of focal increased uptake above the endometrial lesion in the left pelvic cavity was observed on PET CT and MRI, possibly due to a functioning ovary. PET CT and MRI were interpreted as showing a dual concordant malignant lesion due to separated FDG uptakes and high SI without any connection between the cervical and endometrial lesions. F18 FDG PET CT showed intense FDG uptake along the endometrium. Given the patient's history and the fact that she was not menstruating at the time of imaging, this intense uptake was interpreted as another pathologic lesion, suggesting dual primary lesions. A suspected heterogeneous mass lesion along the endometrium suggesting concordant endometrial cancer was found on MRI. Endometrial cancer with cervical extension is sometimes difficult to differentiate from primary cervical cancer. The final histopathologic report showed poorly differentiated endometrial adenocarcinoma with cervical extension, although the FDG PET CT and MRI findings were suggestive of concordant cervical and endometrial cancer. Although histopathologic confirmation is necessary for final diagnosis, MRI and FDG PET CT studies may aid in the differential diagnosis. A metastatic cervical mass from endometrial cancer clinically presenting as cervical myoma is rare. This case suggests that poorly differentiated endometrial cancer may extend into the cervix, presenting as cervical myoma, and the possibility of a metastatic mass should be considered in the differential diagnosis when dealing with cervical myoma.

  12. An Industrial Dental-Erosion by Chromic Acid: A Case Report

    OpenAIRE

    Du?lgergil, C? Tu?rksel; Erdemir, Ebru Olgun; Ercan, Ertug?rul; Erdemir, Ali

    2007-01-01

    A case of uncommon occupational dental erosion was reported in an individual who had worked in the war industry for twenty years. This occupation involved daily, at least 8 hours, inhalation of chromic acid being used for cleaning of barrel of cannons. The erosion manifested as dental sensitivity with excessive cervical erosion even with pulpal exposure in certain teeth. Moreover, due to the adverse effect of the chemical against to gingival and/or periodontal tissues, the lesions were extrem...

  13. Packing effects on the intracavitary radiation therapy of the uterine cervix cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jung Kun; Lee, Du Hyun; Si, Chang Kun; Choi, Yoon Kyung; Kim, Tae Yoon [Proton Therapy Center, National Cancer Center, Seoul (Korea, Republic of)

    2004-03-15

    Purpose of the radio-therapy is maximize the radiation dose to the tumor while minimizing the dose to the critical organ. Carcinoma of the uterine cervix treatment are external irradiation or an interstitial brachytherapy make use of isotope. Brachytherapy is a method of radiotherapy in advantage to achieve better local control with minimum radiation toxicity in comparison with external irradiation because radiation dose is distributed according to the inverse square low of gamma-ray emitted from the implanted sources. Authors make use of the patients data which {sup 192}Ir gives medical treatment intracavity. Intracavitary radiation of the uterine cervix cancer, critical organ take 20% below than exposure dose of A point in the ICRU report. None the less of the advice, Radiation proctitis and radiation cystitis are frequent and problematic early complications in patients treated with radiation for the uterine cervix cancer. In brachytherapy of uterine cervical cancer using a high dose rate remote afterloading system, it is of prime importance to deliver a accurate dose in each fractionated treatment by minimizing the difference between the pre-treatment planned and post-treatment calculated doses. Use of packing to reduce late complications intracavitary radiation of the uterine cervix cancer. Bladder and rectum changes exposure dose rate by radiotherapy make use of packing.

  14. Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107

    OpenAIRE

    Barbie, Thanh U.; Barbie, David A.; Maclaughlin, David T.; Maheswaran, Shyamala; Donahoe, Patricia K.

    2003-01-01

    In addition to causing regression of the Mullerian duct in the male embryo, Mullerian Inhibiting Substance (MIS) inhibits the growth of epithelial ovarian cancer cells, which are known to be of Mullerian origin. Because the uterine cervix is derived from the same Mullerian duct precursor as the epithelium of the ovary, we tested the hypothesis that cervical cancer cells might also respond to MIS. A number of cervical cancer cell lines express the MIS type II receptor, and MIS inhibits the gro...

  15. An analysis of DSA in uterine arteriography in uterine fibroids

    International Nuclear Information System (INIS)

    Objective: The appearances of 152 cases on DSA were analyzed to evaluate the features of blood supply and the bifurcation angle between the uterine artery and inner iliac artery for providing an interventional management guidance. Methods: All 152 cases were diagnosed by ultrasound, CT and MRI including 74 cases with tumor site in muscle layer, 32 beneath the mucosa and 46 with both of the formers. All cases were performed aortography, of them, 91 cases underwent rotational DSA. The bifurcation angle between the uterine artery and inner iliac artery was measured. The bilateral appearances of various phases on DSA and predominant types of blood supply were analyzed and compared. Results: The successful rate of catheterization with DSA was 100%. There were 81 cases (53.3%) with bifurcation angle less than 30 degree, 52 cases (34.2%) between 30 degree and 60 degree, 19 cases larger than 60 degree (12.5%). 112 cases(73.7%) revealed unilateral dominated blood supply, 98 cases with a sign of tumors wrapped by small arteries. The tumor staining signs were seen in 124 cases (81.6%). The bifurcation morphology was clearly displayed in 89 cases (97.8%). Conclusion: The uterine arteries are commonly enlarged asymmetrically in uterine fibroid with rich blood supply demonstrating contrast stain in later phase. Some of the uterine arteries having a large bifurcation angle with the iliac artery, more attention should be taken during the interventional treatment. (authors)rventional treatment. (authors)

  16. Biometric analysis of uterine cervix during pregnancy using trans vaginal ultrasonography and magnetic resonance imaging

    International Nuclear Information System (INIS)

    Objective: To evaluate the uterine cervix length with magnetic resonance imaging in comparison with findings at trans vaginal ultrasonography. Materials and methods: Twenty pregnant women between the 19th and 30th gestational weeks underwent magnetic resonance imaging and trans vaginal ultrasonography for evaluation of their uterine cervix. Measurements by means of magnetic resonance imaging were performed by two specialists in imaging diagnosis for calculating the interobserver variability of the method. Results: Calculation of the Pearson's correlation coefficient between measurements of the cervical length demonstrated a significant correlation between the results of both methods (r=0.628; p<0.01). The paired t test demonstrated no statistically significant difference between measurements obtained by trans vaginal ultrasonography and magnetic resonance imaging (p=0.068). Interobserver agreement in cervical measurements by magnetic resonance imaging was high (?=0.96), demonstrating the reliability of the method. Conclusion: The comparison between both imaging methods in the evaluation of cervical biometry showed no statistically significant difference thus reinforcing the utilization of ultrasonography. However, in some cases where trans vaginal ultrasonography is contraindicated, magnetic resonance imaging can be alternatively utilized for measurement of the cervical length. (author)

  17. Alterações radiográficas de coluna cervical em artrite reumatoide / Radiographic changes of cervical spine in rheumatoid arthritis

    Scientific Electronic Library Online (English)

    Juan Marcelo Fernandez, Alcala; Diogo, Douat; Diogo Lago, Pinheiro; Douglas Jun, Kamei; Fábio Raimundo M dos, Santos; Marilia B, Silva; Thelma L, Skare.

    2013-10-01

    Full Text Available INTRODUÇÃO: O envolvimento da coluna cervical é comum na artrite reumatoide (AR). OBJETIVO: Estudar a prevalência das alterações radiológicas de coluna cervical em pacientes com AR e sua associação com perfil clinico e sorológico da doença. MÉTODOS: Analisaram-se as radiografias de coluna cervical e [...] m perfil neutro hiperextensão, hiperflexão e transoral de 80 pacientes com AR para presença de subluxação atlanto-axial (LAA), invaginação basilar (IB) e instabilidade subaxial (ISA). Dados de perfil demográfico, clínico (nódulos, pneumonite intersticial, síndrome Sjögren secundária, uso de medicamentos etc.) e sorológico (FR, anti-CCP e FAN) foram obtidos por revisão de prontuários. RESULTADOS: Havia alguma alteração de eixo de coluna cervical em 26/80 (32,5%); em 12/80 (15%) havia LAA; em 6/80(7,5%) existia IB; em 13/80 (16,2%) existia ISA. Erosões em odontoide foram vistas 16/80 (20,0%). As alterações do eixo cervical estavam associadas com idade de início da doença e duração da mesma (P = 0,03 e 0,02, respectivamente). Não se encontrou associação das alterações em coluna cervical com raça, gênero, nódulos, pneumonite intersticial, Sjögren secundário, FR, FAN ou anti-CCP. Pacientes com alterações do eixo cervical apresentavam mais erosões de odontoide (P = 0,03). CONCLUSÕES: Alterações radiológicas em eixo de coluna cervical são comuns e aparecem mais frequentemente em indivíduos com diagnóstico mais precoce de AR e maior tempo de doença. Abstract in english INTRODUCTION: The involvement of the cervical spine is a common feature of rheumatoid arthritis (RA). OBJECTIVE: To study the prevalence of radiographic changes of the cervical spine in patients with RA and their association with clinical and serological profiles of the disease. METHODS: We analysed [...] lateral (neutral position, hyperextension, hyperflexion) and transoral views of cervical spine radiographs from 80 individuals with RA to investigate the presence of atlanto-axial subluxation (AAS), basilar invagination (BI), and subaxial instability (SAI). Demographic, clinical (nodules, interstitial pneumonitis, secondary Sjögren's syndrome, medications etc.), and serologic (rheumatoid factor - RF, cyclic citrullinated peptide antibody - anti-CCP, and antinuclear factor - ANF) data were obtained from the clinical records. RESULTS: Cervical spine misalignments were identified in 26/80 (32.5%) participants; AAS occurred in 12/80 (15%) participants, BI in 6/80 (7.5%), and SAI in 13/80 (32.5%). Odontoid erosions were identified in 16/80 (20.0%) participants. Cervical spine misalignment exhibited associations with age at onset and disease duration (P = 0.03 and 0.02, respectively). No associations were identified between the cervical spine changes and the participants' ethnicity or gender, presence of nodules, interstitial pneumonitis, secondary Sjögren's syndrome, RF, ANF, or anti-CCP. The participants with cervical spine misalignment exhibited higher frequencies of odontoid erosion (P = 0.03). CONCLUSIONS: Cervical spine misalignment was a common radiographic finding and occurred more frequently in participants with earlier onset and longer length of RA.

  18. Uterine Fibroids - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Here: Home ? Multiple Languages ? All Health Topics ? Uterine Fibroids URL of this page: http://www.nlm.nih. ... W XYZ List of All Topics All Uterine Fibroids - Multiple Languages To use the sharing features on ...

  19. What Are the Symptoms of Uterine Fibroids?

    Science.gov (United States)

    ... and Publications What are the symptoms of uterine fibroids? Skip sharing on social media links Share this: Page Content ?Uterine fibroids can cause uncomfortable or sometimes painful symptoms, such ...

  20. Cervical synovial cyst.

    Science.gov (United States)

    Attwell, Lukas; Elwell, Vivian A; Meir, Adam

    2014-12-01

    Synovial cysts of the cervical spine are extremely rare. They can therefore pose a diagnostic challenge. We present an unusual case of acute symptomatology secondary to spontaneous haemorrhage into a cervical facet joint cyst. PMID:24801806

  1. Gemcitabine Hydrochloride, Docetaxel, and Radiation Therapy in Treating Patients With Uterine Sarcoma That Has Been Removed By Surgery

    Science.gov (United States)

    2015-01-16

    Stage IA Uterine Sarcoma; Stage IB Uterine Sarcoma; Stage IC Uterine Sarcoma; Stage IIA Uterine Sarcoma; Stage IIB Uterine Sarcoma; Stage IIIA Uterine Sarcoma; Stage IIIB Uterine Sarcoma; Stage IIIC Uterine Sarcoma; Stage IVA Uterine Sarcoma; Stage IVB Uterine Sarcoma; Uterine Corpus Leiomyosarcoma

  2. Pathological study of uterine fibroids after transcatheter uterine artery embolization

    International Nuclear Information System (INIS)

    Pathological changes of uterine fibroid after transcatheter uterine artery embolization (TUAE) has been proven with regular pathological change during the elapse time after TUAE resulting in fibrotic proliferation. Inflammation took place first, followed by coagulation necrosis and hyaline degeneration but incomplete in most cases and finally with proliferative fibrous tissue formation. These dynamic changes of pathology are basis for fibroid volume reduction and recurrences. The factors affecting the extent of fibroid necrosis included tumor size, position and elapse of duration after TUAE. Inflammation was found in normal uterine tissue after TUAE but no necrosis occurred. The finding of embolization agent in peripheral vessels of adnexa may suggest future possible damage of function in ovary and fallopian tube. (authors)

  3. Innovative Oral Treatments of Uterine Leiomyoma

    OpenAIRE

    Mohamed Sabry; Ayman Al-Hendy

    2012-01-01

    Uterine fibroids (leiomyoma), the benign tumors of the uterine wall, are very common cause of morbidity in reproductive age women usually in the form of excessive vaginal bleeding, chronic pelvic pain, miscarriage and infertility. These tumors are the leading indication for hysterectomy in the United States. Uterine fibroids are about 4 times higher in blacks compared to whites and constitute a major health disparity challenge. The estimated cost of uterine fibroids is up to $34.4 billion ann...

  4. Correlation of Traditional Point a With Anatomic Location of Uterine Artery and Ureter in Cancer of the Uterine Cervix

    International Nuclear Information System (INIS)

    Purpose: Point A, used for dose specification for intracavitary brachytherapy for cervical cancer, is the point at which the uterine artery and ureter cross. This study assessed compatibility of commonly used traditional point A (TPA) and actual anatomic point A (APA). Methods and Materials: We visualized and placed radiopaque clips at the APA during pelvic and paraaortic lymphadenectomy in 11 patients with cervical carcinoma. Orthogonal and oblique radiographs were obtained after insertion of brachytherapy applicators. We measured the distance between the TPA and APA and estimated the brachytherapy dose to each of the two points. Results: A total of 64 brachytherapy treatments were performed. The mean distances between the TPA and APA were 5.2 ± 1.0 cm on the right and 5.4 ± 1.1 cm on the left. The estimated brachytherapy doses delivered to the APA as a percentage of the presumed 500-cGy fraction size to the TPA were 35.2% (176.6 ± 59.0 cGy) on the right and 30.0% (150.2 ± 42.9 cGy) on the left. The marked discrepancy in the position of the two points was not related to individual kinetic variations during brachytherapy treatment, tumor size, or bladder filling. Conclusions: The conventional TPA does not provide an accurate estimate of the APA determined during lymphadenectomy, indicating a need to reevaluate the current practice for determining the brachytherapy prescription for cervical cancer. ( (ClinicalTrials.gov) Identifier, NCT00319462)fier, NCT00319462)

  5. Pregnancy after uterine arterial embolization

    Directory of Open Access Journals (Sweden)

    Cláudio E. Bonduki

    2011-01-01

    Full Text Available OBJECTIVE: To evaluate pregnancy outcomes, complications and neonatal outcomes in women who had previously undergone uterine arterial embolization. METHODS: A retrospective study of 187 patients treated with uterine arterial embolization for symptomatic uterine fibroids between 2005-2008 was performed. Uterine arterial embolization was performed using polyvinyl alcohol particles (500-900 mm in diameter. Pregnancies were identified using screening questionnaires and the study database. RESULTS: There were 15 spontaneous pregnancies. Of these, 12.5% were miscarriages (n = 2, and 87.5% were successful live births (n = 14. The gestation time for the pregnancies with successful live births ranged from 36 to 39.2 weeks. The mean time between embolization and conception was 23.8 months (range, 5-54. One of the pregnancies resulted in twins. The newborn weights (n = 14 ranged from 2.260 to 3.605 kg (mean, 3.072 kg. One (7.1% was considered to have a low birth weight (2.260 kg. There were two cases of placenta accreta (12.5%, treated with hysterectomy in one case [6.3%], one case of premature rupture of the membranes (PRM (6.3%, and one case of preeclampsia (6.3%. All of the patients were delivered via Cesarean section. CONCLUSION: In this study, there was an increased risk of Cesarean delivery. There were no other major obstetric risks, suggesting that pregnancy after uterine arterial embolization is possible without significant morbidity or mortality.

  6. Pregnancy after uterine arterial embolization

    Scientific Electronic Library Online (English)

    Cláudio E., Bonduki; Paulo C., Feldner, Jr.; Juliana da, Silva; Rodrigo A., Castro; Marair G. F., Sartori; Manoel J. B. C., Girão.

    Full Text Available OBJECTIVE: To evaluate pregnancy outcomes, complications and neonatal outcomes in women who had previously undergone uterine arterial embolization. METHODS: A retrospective study of 187 patients treated with uterine arterial embolization for symptomatic uterine fibroids between 2005-2008 was perform [...] ed. Uterine arterial embolization was performed using polyvinyl alcohol particles (500-900 mm in diameter). Pregnancies were identified using screening questionnaires and the study database. RESULTS: There were 15 spontaneous pregnancies. Of these, 12.5% were miscarriages (n = 2), and 87.5% were successful live births (n = 14). The gestation time for the pregnancies with successful live births ranged from 36 to 39.2 weeks. The mean time between embolization and conception was 23.8 months (range, 5-54). One of the pregnancies resulted in twins. The newborn weights (n = 14) ranged from 2.260 to 3.605 kg (mean, 3.072 kg). One (7.1%) was considered to have a low birth weight (2.260 kg). There were two cases of placenta accreta (12.5%, treated with hysterectomy in one case [6.3%]), one case of premature rupture of the membranes (PRM) (6.3%), and one case of preeclampsia (6.3%). All of the patients were delivered via Cesarean section. CONCLUSION: In this study, there was an increased risk of Cesarean delivery. There were no other major obstetric risks, suggesting that pregnancy after uterine arterial embolization is possible without significant morbidity or mortality.

  7. Soil and Sediment Erosion

    Science.gov (United States)

    This brief article discusses the effect of soil and sediment erosion and its significance in social and economic aspects. The methods of measuring erosion and knowledge of past erosion rates are also briefly discussed to use as a predictor of future erosion rates.

  8. Ritidoplastia cervical reversa Reverse cervical rhytidectomy

    Directory of Open Access Journals (Sweden)

    Aristoteles Bersou Junior

    2010-09-01

    Full Text Available Rejuvenescimento da região cervical anterior por técnica usualmente utilizada nas ritidoplastias é indicado para casos de pacientes com problemas de flacidez, associada ou não com bandas de platisma, com ou sem adiposidade localizada ou mesmo generalizada. Nos casos em que estes aspectos estão localizados no terço cervical inferior e, em particular, junto à fúrcula esternal e clavículas, observamos a possibilidade de realizar a ritidoplastia cervical reversa.Neck rejuvenation by technique usually used in rhytidectomy is recommended for cases of patients suffering from sagging either or not associated with platisma bands with or without generalized adiposity. In cases which these areas are located in the lower cervical, and particularly near the sternal notch and clavicles, we observed the possibility of reverse cervical rhytedectomy.

  9. Ritidoplastia cervical reversa / Reverse cervical rhytidectomy

    Scientific Electronic Library Online (English)

    Aristoteles, Bersou Junior; Guilherme, Bersou.

    2010-09-01

    Full Text Available Rejuvenescimento da região cervical anterior por técnica usualmente utilizada nas ritidoplastias é indicado para casos de pacientes com problemas de flacidez, associada ou não com bandas de platisma, com ou sem adiposidade localizada ou mesmo generalizada. Nos casos em que estes aspectos estão local [...] izados no terço cervical inferior e, em particular, junto à fúrcula esternal e clavículas, observamos a possibilidade de realizar a ritidoplastia cervical reversa. Abstract in english Neck rejuvenation by technique usually used in rhytidectomy is recommended for cases of patients suffering from sagging either or not associated with platisma bands with or without generalized adiposity. In cases which these areas are located in the lower cervical, and particularly near the sternal [...] notch and clavicles, we observed the possibility of reverse cervical rhytedectomy.

  10. Wind Erosion Research

    Science.gov (United States)

    2006-02-27

    Wind Erosion Research (WER) provides science-based wind erosion technology for environmentally, economically, and socially sustainable agriculture in the United States. This website introduces the Wind Erosion Equation (WEQ), the first model for estimating soil loss by wind from agricultural fields and the newly developed Wind Erosion Prediction System (WEPS) which provides new capabilities assessing plant damage and calculating suspension loss. Simulation models, multimedia archive and history of wind erosion research are available for educators and students.

  11. Soil Erosion Studies

    OpenAIRE

    Godone, Danilo Francesco; Stanchi, Silvia

    2011-01-01

    Soil erosion affects a large part of the Earth surface, and accelerated soil erosion is recognized as one of the main soil threats, compromising soil productive and protective functions. The land management in areas affected by soil erosion is a relevant issue for landscape and ecosystems preservation. In this book we collected a series of papers on erosion, not focusing on agronomic implications, but on a variety of other relevant aspects of the erosion phenomena. The book is divided into th...

  12. Anterior cervical plating

    Directory of Open Access Journals (Sweden)

    Gonugunta V

    2005-01-01

    Full Text Available Although anterior cervical instrumentation was initially used in cervical trauma, because of obvious benefits, indications for its use have been expanded over time to degenerative cases as well as tumor and infection of the cervical spine. Along with a threefold increase in incidence of cervical fusion surgery, implant designs have evolved over the last three decades. Observation of graft subsidence and phenomenon of stress shielding led to the development of the new generation dynamic anterior cervical plating systems. Anterior cervical plating does not conclusively improve clinical outcome of the patients, but certainly enhances the efficacy of autograft and allograft fusion and lessens the rate of pseudoarthrosis and kyphosis after multilevel discectomy and fusions. A review of biomechanics, surgical technique, indications, complications and results of various anterior cervical plating systems is presented here to enable clinicians to select the appropriate construct design.

  13. Uterine artery Doppler flow velocity waveform analysis following uterine fibroid embolisation.

    Science.gov (United States)

    Haugen, G; Novakovic, Z; Kirste, U; Husby, H; Dorenberg, E

    2015-04-01

    The objective was to evaluate the relation of uterine artery Doppler flow pulsatility index (PI) with total uterine volume reduction following bilateral embolisation of uterine fibroids by injection of polyvinyl alcohol particles. Doppler flow velocity was examined before and within 8 days after embolisation (n = 13). Uterine size was assessed by magnetic resonance imaging (MRI) before, and at 3 and 6 months after, the procedure. Mean PI values (mean of right and left side) obtained before embolisation were negatively related to uterine size (r = -0.68, p = 0.010) but not to uterine volume reduction after the procedure. Mean PI values after the procedure were related to the percentage decrease in uterine volume both at 3 (r = 0.74, p = 0.004) and 6 months (p = 0.73, p = 0.005). Doppler ultrasound measures of the uterine arteries may be used to evaluate reduction of uterine size following fibroid embolisation. PMID:25058042

  14. Tissue and serum fluorescence spectroscopy as a marker to monitor radiation therapy in cancer of human uterine cervix

    International Nuclear Information System (INIS)

    During the development of neoplasia epithelial tissues undergo biochemical and structural changes that can manifest in tissue auto-fluorescence. Several research groups have reported the tissue fluorescence spectroscopy for the discrimination of carcinoma or human uterine cervix. And also there have been several reports on using different biomarkers for the detection of cervical cancer. It is attempted to make use of fluorescence spectroscopy technique to monitor the radiation therapy in patients with squamous cell carcinoma of cervix. The clinical samples from 10 patients with stage II and stage III B cervical cancer were analysed. The results showed significant changes in spectral characteristics in tissue fluorescence before and after radiation

  15. Angioarchitecture and endovascular embolization of uterine fibroids

    International Nuclear Information System (INIS)

    Objective: To investigate the angioarchitecture and the efficacy of endovascular embolization of uterine fibroids. Methods: Bilateral internal iliac and uterine arteriography were performed to demonstrate the angioarchitecture in uterine fibroids with Seldinger technique. The feeding arteries of uterine fibroids were super-selectively embolized. Results: The uterine arteries of 30 patients all originated from the iliac arteries of the ipsilateral side. The feeding arteries of uterine fibroids showed bilateral dominance in 16 cases (53%), unilateral dominance in 11 (37%) and unilateral feeding in only 3(10%). All symptoms disappeared after embolization. The fibroids masses decreased averagely by 40% in size at 3-month with ultrasound follow-up, by 55% at 6 months and by 60% at 12 months with a total clinical efficacy of 100%. Conclusions: The key to efficacy and prevention of relapse is to understand the angioarchitecture in order to occlude all the pathological vessels in uterine fibroids. (authors)

  16. Rheumatoid arthritis: Radiological changes in the cervical spine

    International Nuclear Information System (INIS)

    Objective was to describe the radiographic cervical spine changes in rheumatoid arthritis patients.Forty-nine patients (37 females and 12 males ) diagnosed with rheumatoid arthritis at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between June 1998 and December 2000, were studied for their radiographic cervical spine changes . Their mean age at disease onset was 41.4+ 13.4 years (range of 18-73)and mean duration of disease was 9.1+-6.28 years (range of 2-34). Their demographic data including rheumatoid factor status was obtained. Standard conventional radiographs cervical spine were obtained to study the cervical spine changes. Cervical radiographic changes were found in 34 patients (27 females and 7 males) 10 had subluxation (7 with atlanto-axial subluxation,2 with sub-axial subluxation,and one with lateral subluxation ). No vertical impaction was seen. Erosion of odontoid process was seen in one patient .All were rheumatoid seropositive Cervical spine changes in patients with rheumatoid arthritis are common, in particular subluxation in the upper cervical spine. Our study showed somewhat lesser prevalence of these changes. These were clinically correlated with disease duration, female sex, and rheumatoid factor, but were not clinically significant. (author)

  17. Cervical stiffness evaluated in vivo by endoflip in pregnant women

    DEFF Research Database (Denmark)

    Hee, Lene; Liao, Donghua

    2014-01-01

    OBJECTIVE: To determine the stiffness of the pregnant uterine cervix in vivo. METHOD: Five women in early pregnancy and six women in late pregnancy were included. The EndoFlip is a 1-m-long probe with a 12-cm-long bag mounted on the tip. The tip of the probe was inserted into the cervical canal. Sensors spaced at 0.5-cm intervals along the probe were used to determine 16 serial cross-sectional areas of the bag. The diameter of the cervical canal could thereby be determined during inflation with up to 50 ml saline solution. Tissue stiffness was calculated from the geometric profiles and the pressure-strain elastic modulus (EP) at each sensor site. Three parts of the cervix were defined: the uterus-near part, the middle and the vaginal part. The EPmax was defined as the highest EP detected along the cervical canal. RESULTS: The EPmax was always found in the middle part of the cervix. The median EPmax was 243 kPa (IQR, 67-422 kPa) for the early pregnant women and 5 kPa (IQR, 4-15 kPa) for those at term. In theearly pregnant women the stiffness differed along the cervical length (p<0.05) whereas difference along the cervix was not found for late pregnant women. A positive correlation coefficient (Spearman's rho) was established between the EPs of the uterus-near and the middle part (0.84), between the vaginal and the middle part (0.81), and between the uterus-near and the vaginal part (0.85). CONCLUSION: This new method can estimate the stiffness along the cervical canal in vivo. This method may be useful in the clinical examination of the biomechanical properties of the uterine cervix.

  18. Treatment Option Overview (Uterine Sarcoma)

    Science.gov (United States)

    ... therapy to the pelvis. Treatment with tamoxifen for breast cancer . If you are taking this drug , have a pelvic exam every year and report any vaginal bleeding (other than menstrual bleeding) as soon as possible. Signs of uterine sarcoma include abnormal bleeding. Abnormal bleeding from the vagina ...

  19. Uterine leiomyosarcomas and leiomyomas: Two similar uterine solid tumors, totally different for prognosis

    Directory of Open Access Journals (Sweden)

    Andrea Tinelli

    2011-10-01

    Full Text Available The uterine leiomyosarcoma (LMS is a rare sarcoma arising from the smooth muscle cells found within the myometrium, it is clinically aggressive smooth muscle malignancy, accounting for 2% to 6% of uterine malignancies and an annual incidence of 1.7 per 100,000 women. Although uterine malignancies such as endometrial cancer are common, uterine LMS accounts for only 1% of uterine cancers and is a part of uterine sarcomas’ group, who comprises: carcinosarcoma (formerly known as MMMT, malignant mixed Mullerian tumor (40% to 50%, leiomyosarcoma (30% to 40% and endometrial stromal sarcoma (10% to 15%. Every group has its own risk factors, presenting symptoms, treatment response and prognosis.

  20. Identification of biomechanical properties in vivo in human uterine cervix

    DEFF Research Database (Denmark)

    Liao, Donghua; Hee, Lene

    2014-01-01

    BACKGROUND AND AIMS: The course and outcome of pregnancy is closely correlated to change of biomechanical properties of the uterine cervix. The aim of this study was to build a non-linear, fiber reinforced mechanical model of the cervix for estimation of mechanical characteristics of the cervix in early- and term-pregnant women based on recordings of in vivo pressure and diameter by means of the Functional Luminal Imaging Probe (FLIP) technology. MATERIALS AND METHODS: Five early- and six term-pregnant women were examined with a FLIP probe. The bag on the probe was inserted into the cervical canal for concomitant measurement of diameters at 16 serial locations along the canal and the bag pressure. The bag was inflated to a maximum volume of 50ml. A three-fiber-families model including isotropic elastin-dominated matrix and anisotropic collagen was introduced to describe the mechanical behavior of the cervical canal. The unknown geometric and mechanical parameters were calculated on the basis of the mid-cervical diameters and the intraluminal pressures during the inflation. RESULTS: The wall thickness in the unloaded state (zero pressure applied) and mechanical properties of the matrix material (c) and collagens (c1, c2) were estimated with good fits of the calculated intraluminal pressures to the FLIP recordings during the cervical canal distension. No significant difference in the wall thickness was found between the early- and term-pregnant women (10.3±0.8mm vs. 11.7±2.2mm, p=0.30). The cervical matrix material and the collagen in the early-pregnant women were much stiffer than that in the term-pregnant women (p<0.05). CONCLUSIONS: The cervical mechanical properties can be obtained from recorded pressure and diameter data in vivo via the established mechanical model. Matrix material and collagens of the cervix wall were remodeled during pregnancy. The mechanical model can be applied to other tubular visceral organs where concomitant measures of pressure and diameter can be obtained for better understanding diseases and their evolution or treatment.

  1. Diagnostic Value of Endometrial Sampling with Pipelle Suction Curettage for Identifying Endometrial Lesions in Patients with Abnormal Uterine Bleeding

    OpenAIRE

    Behnamfar, F.; Khamehchian, T.; Mazoochi, T.; Fahiminejad, T.

    2004-01-01

    Background: While determining the cause of abnormal uterine bleeding, sampling from the endometrium is necessary. Considering that pipelle suction curettage can be performed on an out patient basis and does not require hospitalization, using anesthesia and cervical dilatation, we performed this study. The aim of this study was to compare the diagnostic value of dilatation and curettage (D&C) with pipelle suction curettage. Methods: This study was quasiexperimental on 200 pre and postmenop...

  2. Radio chemotherapy for uterine cervix carcinoma

    International Nuclear Information System (INIS)

    Low-stage uterine cervix carcinoma can be treated by either surgery, radiation therapy or combined treatments with high cure rates ranging from 90 to 95 % for stage IB1 tumors. However, the standard treatment, combining external beam plus intracavitary radiation, fails to control the progression of the disease in 35 to 90 % of patients with locally advanced cervical cancer. No substantial improvements have been made in the treatment of these tumors in the past two decades. The addition of concurrent 5-FU in a phase III study failed to improve the results in the overall patient population, but the five-year DFS was significantly better in a subset of patients (tumor > 5 cm and IB/IIA or medial parametrial IIB disease). Concurrent chemo-radiation and adjuvant chemotherapy with epirubicin showed, in a phase III study, a significant longer DFS in patients treated with chemotherapy despite the same long-term local tumor control. After many phase II studies, five phase III studies have recently demonstrated a 40 to 60 % reduction in the relative risk of recurrence with cisplatin containing chemo-radiation. Across these studies, the risk of death was reduced by 30 to 50 %. The benefit was less clear in patients with stages III-IV tumors than in patients with lower stages associated with poor prognostic factors. Hematologic and gastrointestinal toxicity of chemo-radiation was greater than that of radiotherapy alone. However, late side effects were similar in the different tre effects were similar in the different treatment groups. These results must be confirmed with a longer follow-up. The importance of concurrent chemotherapy during the brachytherapy procedure should be analyzed. It has yet to be determined which chemotherapy regimen achieves the most favorable therapeutic ratio. (authors)

  3. Breast cancer in Mexican women: an epidemiological study with cervical cancer control Câncer de mama em mulheres mexicanas: estudo epidemiológico com controles de câncer cervical

    OpenAIRE

    Víctor Tovar-Guzmán; Carlos Hernández-Girón; Eduardo Lazcano-Ponce; Isabelle Romieu; Mauricio Hernández Avila

    2000-01-01

    INTRODUCTION: In Mexico, breast cancer (BC) is one of the main causes of cancer deaths in women, with increasing incidence and mortality in recent years. Therefore, the aim of the study is identify possible risk factors related to BC. METHODS: An epidemiological study of hospital cases of BC and controls with cervical uterine cancer (CUCA) was carried out at eight third level concentration hospitals in Mexico City. The total of 353 incident cases of BC and 630 controls with CUCA were identifi...

  4. Treatment Option Overview (Cervical Cancer)

    Science.gov (United States)

    ... Cancer Prevention Cervical Cancer Screening Research Cervical Cancer Treatment (PDQ®) General Information About Cervical Cancer Key Points ... Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) depends on ...

  5. Seismicity and Erosion

    OpenAIRE

    Hovius, Niels; Meunier, Patrick; Dadson, Simon

    2008-01-01

    Earthquakes build topography but also drive erosion. Erosion, in turn, may control seismicity. Nowhere is this two way feedback more evident than in Taiwan. There, patterns of erosion and seismicity are demonstrably correlated, over decades and also at the scale of individual, large earthquakes. At the scale of the mountain belt, the pattern of erosion shares elements with the distribution of cumulative seismic mo- ment, and the relative importance of typhoons. Are these controls independent,...

  6. Cervical Total Disc Arthroplasty

    OpenAIRE

    Basho, Rahul; Hood, Kenneth A.

    2012-01-01

    Symptomatic adjacent segment degeneration of the cervical spine remains problematic for patients and surgeons alike. Despite advances in surgical techniques and instrumentation, the solution remains elusive. Spurred by the success of total joint arthroplasty in hips and knees, surgeons and industry have turned to motion preservation devices in the cervical spine. By preserving motion at the diseased level, the hope is that adjacent segment degeneration can be prevented. Multiple cervical disc...

  7. On dental erosion and associated factors.

    Science.gov (United States)

    Johansson, Ann-Katrin

    2002-01-01

    The aim of this thesis was to explore aspects of dental erosion by investigating its prevalence among young Saudi men and young children, develop a system for its assessment and to evaluate various tentative background factors that may be associated with its occurrence. Saudi military inductees (n = 95) were subjected to questionnaire and clinical examination, including recordings of severity of dental erosion and a number of other oral health parameters. The system applied for grading the severity of dental erosion showed an intraexaminer agreement of 78%. Around one-fourth of the maxillary anterior tooth surfaces exhibited pronounced dental erosion and the average soft drink consumption was 247 liters/year. High level of soft drink consumption and long retention time of the drink in the mouth before swallowing, intensified oral hygiene, mouth breathing and low gingival bleeding index were found to have significant correlations with the presence of dental erosion. Furthermore, less plaque on maxillary palatal tooth surfaces, increased numbers of buccal cervical defects, first permanent molar "cuppings", missing teeth, and lower salivary urea content had significant correlations with the severity of dental erosion. High intake of acidic drinks and fruits, upper respiratory tract problems and frequent taking of medication were common findings in young Saudi children (n = 16) with severe dental erosion. The clinical diagnosis of erosion in deciduous teeth was confirmed by SEM. Enamel from various healthy teeth were subjected to microhardness measurements before and after in vitro exposure to citric acid. Deciduous enamel was found to be softer and relatively more prone to erosion than permanent enamel but the potential for erosion was about the same regardless of the origin of the teeth. Six methods of drinking a sugar-free cola-type drink were assessed in two groups of healthy volunteers. Intraoral pH was measured at specific locations and at predetermined time points using the microtouch method (n = 12), and continuously by using telemetric measurement (n = 6). Of the six methods tested, those in which the drink was in contact with the tooth surface for a prolonged period of time were found to strongly affect intraoral pH. It may be concluded from this thesis that dental erosion is common among young Saudi men and that erosion is associated with many etiological, aggravating and modifying factors. Consumption of soft drinks, amount of palatal plaque on maxillary anterior teeth and salivary urea concentration are some factors related to erosion. The presence of dental erosion in children is likely to be associated with a number of general health and dietary factors but is also aggravated by the relatively more rapid progression of erosion in the deciduous teeth. Drinking method seems to be an important factor in the risk of developing dental erosion. PMID:12617031

  8. The effect of puerperal uterine disease on uterine involution in cows assessed by Doppler sonography of the uterine arteries

    OpenAIRE

    Heppelmann, M.; Weinert, M.; Bro?mmling, A.; Piechotta, M.; Hoedemaker, M.; Bollwein, H.

    2013-01-01

    The objective of this study was to investigate the effects of puerperal uterine disease on uterine blood flow using trans-rectal Doppler sonography. Lactating Holstein Friesian cows (n = 44) were divided into two groups based on whether they were healthy (UD?; n = 23) or had uterine disease (UD+; n = 21) defined as retained fetal membranes and/or metritis. General clinical examination, vaginoscopy, trans-rectal palpation, and trans-rectal B-Mode sonography were conducted on Days 8, 11, 18, ...

  9. Emergency wind erosion control

    Science.gov (United States)

    February through May is the critical time for wind erosion in Kansas, but wind erosion can happen any time when high winds occur on smooth, wide fields with low vegetation and poor soil structure. The most effective wind erosion control is to ensure a protective cover of residue or growing crop thro...

  10. Vaginal Misoprostol for Cervical Priming before Gynaecological Procedures on Non Pregnant Women

    Science.gov (United States)

    Saha, Shyama Prasad; Bhattacharjee, Nabendu; Baru, Gangotri

    2007-01-01

    Background Misoprostol has been extensively researched for its use in obstetrics and has proved to be a very effective cervical softening agent before termination of pregnancy. The beneficial effects on cervical ripening may make misoprostol a desirable agent for helping cervical dilatation on non pregnant women also. The objective is to study the efficacy of preoperative vaginal application of misoprostol as cervical priming agent before gynaecological procedures on non pregnant women. Methods Design: A randomized controlled trial. Setting: Department of Gynaecology and Obstetrics of two medical colleges. Participants: 468 non pregnant pre-menopausal nulli-parous or parous women scheduled to have diagnostic D&C or diagnostic hysteroscopy operations. Interventions: 400 mcg intravaginal misoprostol (229 women) in the study group and 400 mg intravaginal metronidazole as placebo (231 women) in control group. Outcome Measure: The main outcome measures were baseline cervical width at the beginning of the procedures, the number of women who required further cervical dilatation, time taken for dilatation, side effects and other complications. Results : Base line cervical width in the study group was significantly higher than control group (4.6±0.8 mm vs. 3.8±0.7 mm, p < 0.0001). 141 (61.57%) cases required further cervical dilatation in the study group compared to 206 (89.18%) in the control group (p < 0.0001). Time taken for further cervical dilatation was significantly lower in the study group compared to control group (48.3±18.4 sec vs. 68.6±17.3 sec, p < 0.0001). Cervical injury and uterine perforation occurred in 12 and 3 women respectively in the control group compared to 1 and 0 women respectively in the misoprostol group. Two most common side effects of vaginal misoprostol were mild lower abdominal pain (21%) and slight vaginal bleeding (09.2%) which were within tolerable limit. Conclusion: Preoperative vaginal application of misoprostol before gynaecological procedures on non pregnant women decreases the cervical resistance, facilitates the cervical dilatation and operative procedures minimizing cervical or uterine injuries. PMID:21475427

  11. Multimodal management of a pediatric cervical yolk sac tumor.

    Science.gov (United States)

    Saltzman, Amanda F; Gills, Jessie R R; LeBlanc, Dana M; Velez, Maria C; Craver, Randall D; Roth, Christopher C

    2015-05-01

    Even though vaginal bleeding is an unusual clinical presentation in infants and young children, thorough evaluation by the pediatric urologist requires the recognition and knowledge of less-common conditions, including malignancy. Extragonadal germ cell tumors are rare in children aged <15 years, representing approximately 1% of all cancers. Because of the close collaboration between pediatric oncologists and pediatric urologists, a multidisciplinary approach to the management and treatment of these tumors includes chemotherapy and surgical resection, aiming for fertility preservation when possible. We present a 10-month-old infant with a cervical or uterine germ cell tumor and the challenges found during her treatment. PMID:25818907

  12. Hidden bone erosions

    Directory of Open Access Journals (Sweden)

    F. Salaffi

    2011-09-01

    Full Text Available The aim of this pictorial essay was to demonstrate the diagnostic efficacy of high-resolution sonography in detecting bone erosions in a patient with rheumatoid arthritis. Standard X-Ray of the feet did not reveal clearly evident erosions. Ultrasonography was able to detect the presence of bone erosions of the metatarsal heads of both the first toes and of the V toe of the left foot. Because the appearance of bone erosions on radiographs of a patient with a recent onset arthritis indicates a poor prognosis, the possibility of demonstrating small hidden erosions at the level of the early targets of the disease is of relevant practical value.

  13. [Mass screening for uterine cancer].

    Science.gov (United States)

    Tenjin, Y

    1985-12-01

    Begun in the latter half of the sixties, mass screening for uterine cancer received a fresh impetus with the implementation in February of 1983 of the Health of the Aged Act. Under the latter law, a certain number of problems were also encountered, since autonomous municipalities were newly involved. This report is a description of the Pap test under the new screening system and methods of the uterine cancer mass screening approach or the screening system advanced by Japan Society of obstetrics & gynecology, committee on uterine cancer screening. It covers the primary screening, the secondary screening and detailed screening, their roles and manner in which they are implemented in terms of the local situation. Also, the points deserving the greatest care up through the detailed screening are presented. The importance in particular of the results of the Pap test at the stage of the primary screening, the histological findings, and the reliable transaction of the specimens therefrom, are emphasized. For the mass screening for uterine cancer to result in lower cancer mortality, it is necessary that there be at least 30% of the women aged 30 and over who reside in a given district submitting to the mass screening judging from the results garnered both at home and abroad. The measures needed to reach this goal are introduced. The steps conventionally employed to attain this objective of a higher proportion of women being examined, as well as the mass media propaganda, have their limits. The role of the committees for supervising administration of the screening must be amplified as a concrete means to implement the Health of the Aged Act; the role of the municipalities, which support this realization, must be stressed, the importance of administration policy in the form of periodical examinations, examinations focused on the women of certain ages and the plans for testing with due balance in responsibility between mobile and stationary facility examinations, must be upgraded. Communications with the local medical association and related organizations is also crucial. PMID:4073921

  14. Skeletal muscle metastasis from uterine leiomyosarcoma

    International Nuclear Information System (INIS)

    A case of a 68-year-old woman who presented with a rapidly enlarging painful right thigh mass is presented. She had a known diagnosis of uterine leiomyosarcoma following a hysterectomy for dysfunctional uterine bleeding. She subsequently developed a single hepatic metastatic deposit that responded well to radiofrequency ablation. Whole-body MRI and MRA revealed a vascular mass in the sartorius muscle and a smaller adjacent mass in the gracilis muscle, proven to represent metastatic leiomyosarcoma of uterine origin. To our knowledge, metastatic uterine leiomyosarcoma to the skeletal muscle has not been described previously in the English medical literature. (orig.)

  15. Cervical Discitis in Children.

    Science.gov (United States)

    Scheuerman, Oded; Landau, Daniel; Schwarz, Michael; Hoffer, Vered; Marcus, Nufar; Hoffnung, Liat Ashkenazi; Levy, Itzhak

    2015-07-01

    Cervical discitis, though rare, should be included in the differential diagnosis of torticollis, neck pain and neurodevelopmental regression in motor skills in children and infants. Magnetic resonance imaging is the diagnostic method of choice. Treatment should be conservative with antibiotics only. The aim of this study was to describe the 10-year experience of a tertiary pediatric medical center with cervical discitis. PMID:25886786

  16. Surgical uterine drainage and lavage as treatment for canine pyometra : clinical communication

    Directory of Open Access Journals (Sweden)

    K.G.M. De Cramer

    2012-05-01

    Full Text Available Pyometra is a common post-oestral syndrome in bitches. Classical treatment consists of either ovariohystorectomy or medical intervention. Surgical uterine drainage and lavage via direct trans-cervical catheterisation using a 5% povidone-iodine in saline solution was performed successfully in 8 bitches with pyometra. All bitches conceived and whelped without complications subsequent to this treatment. It is concluded that this method offers an effective alternative treatment for canine pyometra with shorter recovery times as well as good clinical recovery and pregnancy rates in bitches destined for further breeding.

  17. Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer

    OpenAIRE

    Jing Ji; Juan Liu; Haijuan Liu; Yueling Wang

    2014-01-01

    The purpose of this study was to investigate the effect of fermented mushroom of Cordyceps sinensis (CS), rich in selenium (Se-CS), on uterine cervical cancer in mice. The methylcholanthrene- (MCA-) induced tumor model was used in this paper. After the mice were administered Se-CS, the animals showed 40% tumor incidence (P < 0.05). Se-CS also enhanced the immune functions. Se-CS treatment showed significant (P < 0.05–0.01) restoration in the level of glutathione content, lipid peroxidation...

  18. Breast cancer in Mexican women: an epidemiological study with cervical cancer control

    OpenAIRE

    Tovar-Guzmán Víctor; Hernández-Girón Carlos; Lazcano-Ponce Eduardo; Romieu Isabelle; Hernández Avila Mauricio

    2000-01-01

    INTRODUCTION: In Mexico, breast cancer (BC) is one of the main causes of cancer deaths in women, with increasing incidence and mortality in recent years. Therefore, the aim of the study is identify possible risk factors related to BC. METHODS: An epidemiological study of hospital cases of BC and controls with cervical uterine cancer (CUCA) was carried out at eight third level concentration hospitals in Mexico City. The total of 353 incident cases of BC and 630 controls with CUCA were identifi...

  19. Proposal to institutionalize criteria and quality standards for cervical cancer screening within a health care system

    OpenAIRE

    Salmerón-Castro Jorge; Lazcano Ponce Eduardo César; Pérez Cuevas Ricardo; Río Gómez Iliana del; Torres Torija Irene; Hernández Avila Mauricio

    1998-01-01

    The uterine cervix is the most common cancer site for females. Approximately 52,000 new cases occur annually in Latin America, thus the need to improve efficiency and effectiveness of Cervical Cancer Screening Programs (CCSP) is mandatory to decrease the unnecessary suffering women must bear. This paper is addressing essential issues to revamp the CCSP as proposed by the Mexican official norm. A general framework for institutionaling CCSP is outlined. Furthermore, strategies to strengthen CCS...

  20. Inter-individual variance in micronuclei frequency in lymphocytes of patients with cervical insufficiency

    OpenAIRE

    Gruji?i? Darko; Arsenijevi? Slobodan; Marinkovi? Dragoslav; Miloševi?-?or?evi? Olivera

    2013-01-01

    The aim of this work was to explain the inter-individual variance in baseline and induced micronuclei (MN) frequency in peripheral blood lymphocytes (PBLs) of females with uterine cervical insufficiency. The baseline and induced MN response of the PBLs in 32 patients were investigated using the cytokinesis-block micronucleus (CBMN) method. The obtained mean values of induced MN frequency (11.31 ± 4.44/1000 BN cells), were significantly higher (p < 0.001) i...

  1. Ex vivo assessment of mouse cervical remodeling through pregnancy via 23Na MRS

    OpenAIRE

    Xu, Xiang; Akgul, Yucel; MAHENDROO, Mala; Jerschow, Alexej

    2010-01-01

    Preterm birth occurs in 12.5% of births in the United States and can lead to risk of infant death or to lifelong serious health complications due to prematurity. A greater understanding by which the two main processes, uterine contraction and cervical remodeling are regulated is required to reduce rates of preterm birth. The cervix must undergo extensive remodeling through pregnancy in preparation for parturition, the process of labor and delivery of young. One key aspect of this dynamic proc...

  2. Selective artery embolization for treatment of uterine myoma

    International Nuclear Information System (INIS)

    Objective: To assess the clinical effects of selective embolization of uterine arteries in the treatment of uterine myomata. Methods: 15 cases with symptomatic uterine myomata were treated by Seldinger's selective uterine arteries embolization. After a percutaneous femoral arterial puncture, an artery catheter was selectively inserted into bilateral uterine arteries. The insertion silk of fragments and gel form were introduced through catheter to occlude the blood supply of myoma. Results: Arteriography showed that most uterine myomata were supplied by bilateral uterine arteries. When both uterine arteries were embolized, the blood supply of uterine myoma could be occluded. With a mean follow-up of 6 months the menorrhagia and menstrual cycles returned to normal and, pain resolved. Conclusions: Selective uterine artery embolization is a new method for treatment of uterine myomata with less trauma

  3. Analysis of complications for the treatment of uterine fibroids with bilateral uterine artery superselective embolization

    International Nuclear Information System (INIS)

    Objective: To discuss the complications of the bilateral uterine artery superselective embolization for uterine fibroids. Methods: Forty one cases (mean 42 years old) with uterine fibroids were approached by right femoral artery puncture; including thirty six cases of single hysteromyoma (33 cases with diameter 10 cm). and 5 cases of multi hysteromyoma. Bilateral uterine artery super selective 5F catheterization embolization were done along uterine descending artery (neck of uterus to vagina) with PVA particles. Results: Embolization succeeded with 100% and effective ratio was 90.3%. Sixteen of these cases showed post embolization syndrome, with something outflowed from vagina and 10 cases showed changes of emmenia but with no serious complications in all 41 cases. Conclusion: Using bilateral uterine artery superselective embolization for uterine fibroids with PVA grains can decrease the incidence of complications. (authors)

  4. Uterine cervix cancer and pregnancy

    International Nuclear Information System (INIS)

    Objective: Describe a pathology with a high incidence in our means, in association with pregnancy in this case, graphically report they type of cervical malignancy, clinical manifestations, diagnose and treatment according to stage. Clinical case: We present a young patient with cervical pathology (endofitic bleeding lesion) diagnosed during the first trimester of pregnancy, with complete pregnancy, that consult because of genital bleeding, founding an endofitic lesion by colposcopic exam and which biopsy and pap test reported a scamous cell carcinoma, image diagnostic procedures reveal a 6 month product, that after surgical ending of pregnancy, wa treated by radical hysterectomy. Conclusions: It is important to recognize that in cervical pathology; cervical cancer during pregnancy is a great challenge for the specialist, the diagnostic evaluation that includes biopsies, must be realized in the same way, except from the endocervical canal. The treatment of choice for women is early stages of pregnancy is radical hysterectomy, during the last half of pregnancy it is possible to wait the viability of the product planning the childbirth surgically as soon as possible. (The author)

  5. Efficacy of transcatheter uterine artery embolization for treating emergency hemorrhage obstetrics and gynecology

    International Nuclear Information System (INIS)

    Objective: To evaluate the efficacy of selective iliac artery embolization (TAE) or uterine artery embolization (UAE) for treatment of emergency hemorrhage in obstetrics and gynecology. Methods: Selective bilateral TAE or UAE were performed on 59 patients with acute cervical hemorrhage from postpartum hemorrhage (30), cervical cancer (16), endometrial cancer (8), and choriocarcinoma (5). Gelfoam particles were used in postpartum hemorrhage; chemotherapeutics and Iodipin suspension were used in malignancy. Results: Bleeding was stopped completely in all 59 patients with TAE or UAE procedure time of 30-50 minutes (mean: 42.17±4.78 minutes). There were no serious complications. Conclusion: TAE or UAE are effective for treating emergency hemorrhage in obstetrics and gynecology. (authors)

  6. Co-fatores do HPV na oncogênese cervical / HPV Cofactors in cervical carcinogenesis

    Scientific Electronic Library Online (English)

    ÁLVARO P., PINTO; SIUMARA, TULIO; OLÍVIA RUSSO, CRUZ.

    2002-03-01

    Full Text Available O papilomavírus humano (HPV) exerce um papel central na carcinogênese do colo uterino. Em torno a ele orbitam outros fatores que influenciam direta ou indiretamente a instalação deste mecanismo no epitélio escamoso cervical. Investigações a respeito dos mecanismos de atuação e interação desses co-fa [...] tores com os elementos virais encontram-se na literatura dos últimos 20 anos. O presente artigo de revisão explora os possíveis co-fatores do HPV na gênese do carcinoma escamoso do colo uterino, levando em conta apenas os fatores cuja associação com o vírus ou câncer cervical tenha sido documentada experimentalmente, e não apenas clínica ou epidemiologicamente. Dentre os parâmetros abordados estão os fatores imunológicos (resposta imune local e humoral), a associação com a Síndrome da Imunodeficiência Adquirida Humana, fatores genéticos como o polimorfismo da proteína p53, o tabagismo e o uso de contraceptivos orais. Todos estes fatores interagem em menor ou maior intensidade com oncoproteínas e outros elementos do HPV, potencializando a ação do vírus na célula hospedeira e facilitando o desenvolvimento dos processos de imortalização e carcinogênese. Abstract in english Human papillomavirus (HPV) plays a central rule in uterine cervix carcinogenesis. Other factors direct or indirectly influence the installation of this mechanism in cervical squamous epithelium. Investigations regarding mechanisms of interaction of these factors with viral elements are found in the [...] literature of the last 20 years. The present review article discusses possible co-factors of HPV in the genesis of the squamous carcinoma of uterine cervix, taking into account only the factors whose association with the virus or cervical cancer has been documented by experimental studies, and not based just on clinical or epidemiological data. Among the approached parameters are immunological factors (local and humoral immune response), the association with Acquired Immune Deficiency Syndrome, genetic factors as protein p53 polymorphism, tabagism and the use of oral contraceptives. All these factors interact in variable intensity with oncoproteins and other HPV elements, increasing and facilitating the virus action in host cells, leading to the development of immortalization and carcinogenesis.

  7. Technique and methods in uterine leiomyoma embolization

    International Nuclear Information System (INIS)

    Uterine leiomyomas are the most common benign tumors of the female urogenital tract. Beside the classic surgical treatment options the minimal-invasive embolization therapy of the leiomyomas increasingly gains importance world-wide. Technique, complications, and results of uterine leiomyoma embolization will be presented. After careful evaluation of indications for embolization the procedure is mostly performed under conscious sedation. A single-sided femoral access route together with cross-over technique generally allows for a flow-directed embolization via both uterine arteries. After embolizing the vessels supplying the tumor, the uterine arteries should be still patent. The success rate of embolization of uterine leiomyomas ranges between 85 and 100%, whereas a reduction in size of the tumors in 42 to 83% and a relief of symptoms in up to 96% can be achieved. The total complication rate is about 10% with mainly ''minor complications''. Worldwide only three deaths following embolization of uterine leiomyomas were reported. The high technical and clinical success rate together with a low complication rate make the embolization of uterine leiomyomas a minimally-invasive alternative to the classic treatment. As long term results are not available indication to embolization of uterine leiomyomas must be carefully established in consensus with gynecologists. (orig.)

  8. Abnormal uterine bleeding. Diagnostic value of hysteroscopy.

    OpenAIRE

    Madan, S. M.; Al-jufairi, Z. A.

    2001-01-01

    OBJECTIVES To determine the specificity, sensitivity and predictive value of hysteroscopic impression versus histological diagnosis of endometrial curettings in evaluating patients with abnormal uterine bleeding. In addition, to determine whether office hysteroscopy can eliminate hospital diagnostic dilatation and curettage for patients with abnormal uterine bleeding. METHODS A retrospective study of 556 patients who underwent hysteroscopy and dilatation and curettage for abnormal ut...

  9. The impact of Human papilloma virus (HPV infection on the development of cervical neoplasia

    Directory of Open Access Journals (Sweden)

    Vlad Gheorghita

    2008-08-01

    Full Text Available The genesis of uterine cervix carcinoma has as central etiology the active infection of human papilloma virus (HPV, especially high oncogenic risk subtypes. However, this is a necessary, but not sufficient cause of virtually all cases of cervical cancer worldwide. At present, the proportion of cervical carcinomas attributed to HPV infection is estimated at 99%. It is considered that the pathogenesis of cervical carcinoma is the result of the proliferation of one or, at most, a few HPV-infected cells. Invasive cervical cancer arises in cervical intraepithelial neoplasia, which in turn develops preferentially in squamous metaplasia of certain limited areas. These areas represent the most important morphologic characteristic in cervical intraepithelial neoplasia. It is still unknown the precise mechanism for the development of separate fields in HPV-related intraepithelial neoplasia and the variable susceptibility of reserve cells for different HPV genotypes. The goal of any cervical cancer screening test is to identify women who are at risk of cervical cancer development and to reassure others that do not belong to this category. Cervical cytology (Pap smears were the primary screening tests. More recently, carcinogenic HPV DNA testing has been included as adjunctive test or as a primary screening test based on the central role of carcinogenic HPV infection in the development of cervical cancer. New biomarkers, including those that measure the interaction of host and virus, are being considered either as stand-alone molecular assays or in conjunction with cytology or carcinogenic HPV DNA testing to improve its sensitivity or specificity, respectively. .Profilactic HPV vaccination of women who are sexually active may provide protection against HPV-16 or HPV-18 infection which may lead to cytological abnormalities, precancer or cancer.

  10. Impacts of soil erosion

    OpenAIRE

    Dorren, Luuk; La Rosa, Diego; Theocharopoulos, Sid P.

    2004-01-01

    3.1 Definition of soil functions, soil quality and quality targets The identification of soil functions, properties and processes which are affected by soil erosion is needed to evaluate the impacts of erosion on the soil system. Definition of soil loss tolerance according to soil types and environmental characteristics. 3.2 Development of criteria and indicators to assess soil sustainable use and soil protection measures What are the impacts of soil erosion on soil...

  11. [Cervical conization in the diagnosis and treatment of cervical epithelial neoplasms].

    Science.gov (United States)

    Soldà, A; Volonterio, A; Ferutta, P; Canino, A; Ragazzi, G; Cecchini, G; Cicchetti, G

    1989-06-01

    Thirty-seven patients who underwent cone biopsy for cervical intraepithelial neoplasia (CIN) of varying gravity have been considered. The follow-up points to the therapeutic as well as diagnostic value of this intervention (92% success). Analysis of the responses provided by colpocytology in comparison with those provided by biopsy, evidences the poor diagnostic reliability of the pap-test with respect to intraepithelial lesions of the uterine cervix (under-estimated in 51% of cases compared to biopsy). Operation did not substantially modify patients' reproductive capability (5 pregnancies of which 3 developing, during the control period) an extremely important factor in view of the young age of patients (average 31 years). PMID:2771140

  12. Coexistence of early microinvasive endometrioid adenocarcinoma and CIN3 in the uterine cervix in a 32-year-old Japanese woman

    Directory of Open Access Journals (Sweden)

    Terada Tadashi

    2011-06-01

    Full Text Available Abstract Simultaneous occurrence of early microinvasive endometrioid adenocarcinoma (EMEA and CIN 3 in the uterine cervix is very rare in Japan. A 32-year-old Japanese woman was pointed out to have atypical cells in the cervical cytology. Colposcopic examination revealed irregular lesions in the cervix, and a biopsy showed simultaneous EMEA and CIN3. The EMEA was grade I and CIN3 corresponded to severe dysplasia/carcinoma in situ. Hysterectomy and lymph nodes dissection were performed. Grossly, mucosal irregularity and erosion were seen in the cervix. No tumor formation was recognized. The cervix was examined by serial sections. Microscopically, there were a tiny adenocarcinoma (0.5 cm in diameter and 0.3 cm in depth and broad areas of CIN3. The adenocarcinoma was EMEA without mucins. The EMEA was FIGO stage 1A1. Immunohistochemically, the EMEA was positive for pancytokeratins (AE1/2 +++, CAM5.2 ++, cytokeratin (CK 34?E12 +, CK5/6 +, CK7 +, CK18 +++, CK19 ++, CA19-9 +, CA125 +++, p53 +, ER +++, PgR +++, while it was negative for CK8, CK14, CK20, EMA, vimentin, CEA, desmin, smooth muscle actin, p63, chromogranin, synaptophysin, CD56, CD68, HER2/neu, MUC1, MUC2, MUC5AC, and MUC6. The CIN 3 was positive for pancytokeratins (AE1/2 +++, CAM5.2 +, cytokeratin (CK 34?E12 +++, CK5/6 +++, CK7 +, EMA, CA19-9 +, CA125 +, p53 +, p63 +++, ER +++, and MUC1 +, while it was negative for CK8, CK14, CK18, CK19, CK20, vimentin, CEA, desmin, smooth muscle actin, chromogranin, synaptophysin, CD56, CD68, PgR, HER2/neu, MUC2, MUC5AC and MUC6. The lymph nodes showed no metastatic lesions (0/34. In conclusion, the author reported a rare case of simultaneous EMEA and CIN 3 with extensive immunohistochemical findings.

  13. Cervical osteophyte induced dysphagia

    International Nuclear Information System (INIS)

    Although cervical spondylosis is a common disorder, dysphagia induced by osteophyte formation is uncommon. Fewer than one hundred cases of cervical osteophyte induced dysphagia have been reported, with little attention to the diagnosis by barium swallow. The radiological features of two cases treated surgically with good results are described. Both cases complained of dysphagia while one had associated respiratory obstruction on forward flexion of his neck. The features on barium study of cervical osteophytes causing dysphagia include deformity at the level of osteophyte formation, in both AP and lateral projections. Tracheal aspirations due to deformity at the laryngeal inlet and interference with epiglottic retroversion may be present. 8 refs., 3 figs

  14. DNA of HPV and antibodies toward the protein E7 of HPV 16 as prediction factors in women with cervical cancer submitted to radiotherapy

    International Nuclear Information System (INIS)

    The effects of HPV infection on intrinsic tumor cell sensitivity to radiation therapy (RT) are not clear. Antibodies to HPV16-E7 protein are consistently detected in cervical cancer patients, the changes in the levels of these antibodies after RT thus may have prognostic implications. The aim of this study was to evaluate the antibodies to HPV16-E7 protein and the HPV status in cervical cancer patients before and after RT and to correlate these with clinic pathological parameters. Antibodies to peptide E7 and HPV DNA status before and after RT could have prognosis significance for patients with locally advanced uterine cervical carcinoma

  15. Preoperative Uterine Artery Embolization (PUAE) Before Uterine Fibroid Myomectomy

    International Nuclear Information System (INIS)

    Purpose. To evaluate the potential of uterine artery embolization to minimize blood loss and facilitate easier removal of fibroids during subsequent myomectomy. Methods. This retrospective study included 22 patients (median age 37 years), of whom at least 15 wished to preserve their fertility. They presented with at least one fibroid (mean diameter 85.6 mm) and had undergone preoperative uterine artery embolization (PUAE) with resorbable gelatin sponge. Results. No complication or technical failure of embolization was identified. Myomectomies were performed during laparoscopy (12 cases) and laparotomy (9 cases). One hysterectomy was performed. The following were noted: easier dissection of fibroids (mean 5.6 per patient, range 1-30); mean intervention time 113 min (range 25-210 min); almost bloodless surgery, with a mean peroperative blood loss of 90 ml (range 0-806 ml); mean hemoglobin pretherapeutically 12.3 g/dl (range 5.9-15.2 g/dl) and post-therapeutically 10.3 g/dl (range 5.6-13.3 g/dl), with no blood transfusion needed. Patients were discharged on day 4 on average and the mean sick leave was 1 month. Conclusion. Preoperative embolization is associated with minimal intraoperative blood loss. It does not increase the complication rate or impair operative dissection, and improves the chances of performing conservative surgery

  16. The significance of characteristic angiographic uterine artery anatomy for uterine fibroid artery embolization

    International Nuclear Information System (INIS)

    Objective: To study the angiographic characteristics of uterine fibroid and evaluate its clinical significance. Methods: The diagnosis of 75 patients was assumed by clinical symptoms, color Doppler ultrasound and/or CT imaging. Among them, the sites of fibroids were 9 under mucous membranes, 50 in the myometrium, 16 under serous membrane. After puncture the right femoral artery followed by angiography of bilateral uterine arteries, the origin of the uterine artery with its branches especially the ovarian arteries was demonstrated including the angiographic characteristics of uterine fibroids of different types were clearly shown. Then UAE was undertaken. Results: 1. Most of the uterine arteries were originated from the trunk of inferior gluteal and internal pudendal artery and less from the internal iliac artery and superior gluteal artery. 2. The blood supply of the neoplasm was classified by: 1) from both uterine arteries equally; 2) mainly from one uterine artery; 3) simply from one uterine artery. 3. The ovarian artery may be embolized inevitably, and its clinical effects need further evaluation. Conclusions: Treating the uterine fibroid by embolization of uterine artery is an effective method. Being familiar with the local angiographic anatomy is of great importance for improving the successful rate and choosing the method reasonably. (authors)

  17. EMBARAZO ECTÓPICO ÍSTMICO-CERVICAL EN CICATRIZ DE CESÁREA PREVIA

    Scientific Electronic Library Online (English)

    Ricardo, Yáñez M; Pamela, Martínez B; Yasna, Ibáñez D; Carlos, Benavides B; Aníbal, Vega C.

    Full Text Available El embarazo localizado dentro de una cicatriz de cesárea previa es el menos frecuente de los embarazos ectópicos y no existe un tratamiento estándar. Se presenta el caso clínico de una paciente con embarazo ectópico ístmico-cervical sobre una cicatriz de cesárea. Se hospitaliza por el riesgo de rupt [...] ura uterina, evolucionó con invasión trofoblástica de la histerorrafia culminando en muerte embrionaria. No hubo complicaciones maternas. Se trató con metotrexato para evitar la progresión de la invasión trofoblástica, con buen resultado materno Abstract in english The pregnancy within a cesarean scar is the most infrequent of ectopic pregnancy and there are no standard treatments. This is a case of a patient with ectopic pregnancy within the scar of a previous cesarean of isthmic-cervical location. She is admitted for risk of uterine rupture and with uterine [...] scar trofoblastic invasion, ending in an embryonic death, without maternal complications. The treatment was methotrexate, avoiding trofoblastic invasion, with a favorable maternal outcome

  18. Chromosomal imbalances in four new uterine cervix carcinoma derived cell lines

    Directory of Open Access Journals (Sweden)

    Vázquez Guelaguetza

    2003-03-01

    Full Text Available Abstract Background Uterine cervix carcinoma is the second most common female malignancy worldwide and a major health problem in Mexico, representing the primary cause of death among the Mexican female population. High risk human papillomavirus (HPV infection is considered to be the most important risk factor for the development of this tumor and cervical carcinoma derived cell lines are very useful models for the study of viral carcinogenesis. Comparative Genomic Hybridization (CGH experiments have detected a specific pattern of chromosomal imbalances during cervical cancer progression, indicating chromosomal regions that might contain genes that are important for cervical transformation. Methods We performed HPV detection and CGH analysis in order to initiate the genomic characterization of four recently established cervical carcinoma derived cell lines from Mexican patients. Results All the cell lines were HPV18 positive. The most prevalent imbalances in the cell lines were gains in chromosomes 1q23-q32, 3q11.2-q13.1, 3q22-q26.1, 5p15.1-p11.2, this alteration present as a high copy number amplification in three of the cell lines, 7p15-p13, 7q21, 7q31, 11q21, and 12q12, and losses in 2q35-qter, 4p16, 6q26-qter, 9q34 and 19q13.2-qter. Conclusions Analysis of our present findings and previously reported data suggest that gains at 1q31-q32 and 7p13-p14, as well as losses at 6q26-q27 are alterations that might be unique for HPV18 positive cases. These chromosomal regions, as well as regions with high copy number amplifications, coincide with known fragile sites and known HPV integration sites. The general pattern of chromosomal imbalances detected in the cells resembled that found in invasive cervical tumors, suggesting that the cells represent good models for the study of cervical carcinoma.

  19. Vaccinating against cervical cancer

    OpenAIRE

    Jane Parry

    2007-01-01

    Since last year, it has become possible to vaccinate against the human papillomavirus (HPV) that causes most cases of cervical cancer, but countries face tough decisions before making the vaccine widely available.

  20. Smoking and Cervical Cancer

    Science.gov (United States)

    Smoking and Cervical Cancer If you smoke, you have an increased chance of developing precancerous lesions of ... returning for follow-up appointments, and to Stop Smoking! Copyright © 2003, 2008 American Society for Colposcopy and ...

  1. Cervical Cancer Prevention

    Science.gov (United States)

    ... mainly through sexual contact. Women who become sexually active at a young age and who have many sexual partners are at a greater risk of HPV infection and developing cervical cancer. Smoking Smoking cigarettes and breathing in secondhand smoke increase ...

  2. Enzymes of the AKR1B and AKR1C subfamilies and uterine diseases

    Directory of Open Access Journals (Sweden)

    TeaLanisnik Rizner

    2012-03-01

    Full Text Available Endometrial and cervical cancers, uterine myoma, and endometriosis are very common uterine diseases. Worldwide, more than 800,000 women are affected annually by gynecological cancers, as a result of which, more than 360,000 die. During their reproductive age, about 70% of women develop uterine myomas, 10% to 15% suffer from endometriosis, and 35% to 50% from infertility associated with endometriosis. Uterine diseases are associated with aberrant inflammatory responses and concomitant increased production of prostaglandins (PG. They are also related to decreased differentiation, due to low levels of protective progesterone and retinoic acid, and to enhanced proliferation, due to high local concentrations of estrogens. The pathogenesis of these diseases can thus be attributed to disturbed PG, estrogen and retinoid metabolism and actions. Five human members of the aldo-keto reductase 1B (AKR1B and 1C (AKR1C superfamilies, i.e., AKR1B1, AKR1B10, AKR1C1, AKR1C2 and AKR1C3, have roles in these processes and can thus be implicated in uterine diseases. AKR1B1 and AKR1C3 catalyze the formation of PGF2alpha which stimulates cell proliferation. AKR1C3 converts PGD2 to 9alpha,11beta-PGF2, and thus counteracts the formation of 15deoxy-PGJ2, which can activate pro-apoptotic peroxisome-proliferator-activated receptor beta. AKR1B10 catalyzes the reduction of retinal to retinol, and in thus lessens the formation of retinoic acid, with potential pro-differentiating actions. The AKR1C1-AKR1C3 enzymes also act as 17-keto- and 20-ketosteroid reductases to varying extents, and are implicated in increased estradiol and decreased progesterone levels. This review comprises a short introduction to uterine diseases, followed by an overview of the current literature on the AKR1B and AKR1C expression in the uterus and in uterine diseases. The potential implications of the AKR1B and AKR1C enzymes and their pathophysiologies are then discussed, followed by conclusions and future perspectives.

  3. Adjuvant postoperative radiation therapy for carcinoma of the uterine cervix

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Ja; Moon, Hye Seong; Kim, Seung Cheol; Kim, Chong Il; Ahn, Jung Ja [College of Medicine, Ewha Womans Univ., Seoul (Korea, Republic of)

    2003-09-01

    This study was undertaken to evaluate the efficacy of postoperative radiotherapy, and to investigate the prognostic factors for FIGO stages IB-IIB cervical cancer patients who were treated with simple hysterectomy, or who had high-risk factors following radical hysterectomy and pelvic lymph node dissection. Between March 1986 and December 1998, 58 patients, with FIGO stages IB-IIB cervical cancer were included in this study, The indications for postoperative radiation therapy were based on the pathological findings, including lymph node metastasis, positive surgical margin, parametrial extension, Iymphovascular invasion, invasion of more than half the cervical stroma, uterine extension and the incidental finding of cervix cancer following simple hysterectomy. All patients received external pelvic radiotherapy, and 5 patients, received an additional intracavitary radiation therapy. The radiation dose from the external beam to the whole pelvis was 45 - 50 Gy. Vagina cuff irradiation was performed, after completion of the external beam irradiation, al a low-dose rate of CS-137, with the total dose of 4488-4932 chy (median: 4500 chy) at 5 mm depth from the vagina surface. The median follow-up period was 44 months (15-108 months), The 5-yr actuarial local control rate, distant free survival and disease-free survival rate were 98%, 95% and 94%, respectively. A univariate analysis of the clinical and pathological parameters revealed that the clinical stage (p=0.0145), status of vaginal resection margin (p=0.0002) and parametrial extension (p=0.0001) affected the disease-free survival. From a multivariate analysis, only a parametrial extension independently influenced the disease-free survival. Five patients (9%) experienced Grade 2 late treatment-related complications, such as radiation proctitis (1 patient), cystitis (3 patients) and lymphedema of the leg (1 patient). No patient had grade 3 or 4 complications. Our results indicate that postoperative radiation therapy can achieve good local control and survival rates for patients with stages IB-IIB cervical cancer, treated with a simple hysterectomy, as well as for those treated with a radical hysterectomy, and with unfavorable pathological findings. The prognostic factor for disease-free survival was invasion of the parametrium. The prognostic factor identified in this study for treatment failure can be used as a selection criterion for the combined treatment of radiation and chemotherapy.

  4. Sexually Transmitted Cervicitis

    OpenAIRE

    Romanowski, Barbara

    1989-01-01

    Cervical infections with Neisseria gonorrhoeae, Chlamydia trachomatis, and Herpes simplex virus are some of the most common sexually transmitted infections. They are often asymptomatic, and therefore the patient is at risk of developing complications, such as pelvic inflammatory disease. It is important to recognize cervicitis, investigate it appropriately, and provide early treatment. Sexual partners must also be located and offered therapy to prevent re-infection in the index patient.

  5. Cervical spine trauma

    OpenAIRE

    Torretti Joel; Sengupta Dilip

    2007-01-01

    Cervical spine trauma is a common problem with a wide range of severity from minor ligamentous injury to frank osteo-ligamentous instability with spinal cord injury. The emergent evaluation of patients at risk relies on standardized clinical and radiographic protocols to identify injuries; elucidate associated pathology; classify injuries; and predict instability, treatment and outcomes. The unique anatomy of each region of the cervical spine demands a review of each segment individually. Thi...

  6. Coastal Erosion Online Discussion

    Science.gov (United States)

    Sheila Roberts

    The students are given the following: Read the articles below about erosion along the Lake Erie shoreline and discuss them. What causes the erosion? What can be done to prevent erosion? Should people be allowed to build structures to protect their property from erosion? Should people be allowed to live along the shoreline in high erosion areas? Students are expected to have completed the coastal erosion module (read text book, view powerpoint lecture and take a quiz) and read articles regarding coastal erosion along the Lake Erie coastline. In the online discussion, students must show that they understand coastal processes, the impact of man made structures on coastal processes, and can apply their values as they discuss what should be done, if anything, to reduce the impact of coastal erosion. Teaching Tips Adaptations that allow this activity to be successful in an online environment This was designed as an online activity. I have also used it in face-to-face courses (students participate in online discussion prior to in-class discussion). Elements of this activity that are most effective This gets students thinking about how what they learn in class can be used to solve real problems faced by the local community and/or the world. Although some students propose impractical solutions, they are at least thinking. Recommendations for other faculty adapting this activity to their own course: Find local issues and/or global issues that show how geology can be used to solve problems.

  7. Saliva and dental erosion

    Scientific Electronic Library Online (English)

    Marília Afonso Rabelo, Buzalaf; Angélicas Reis, Hannas; Melissa Thiemi, Kato.

    2012-10-01

    Full Text Available Dental erosion is a multifactorial condition. The consideration of chemical, biological and behavioral factors is fundamental for its prevention and therapy. Among the biological factors, saliva is one of the most important parameters in the protection against erosive wear. Objective: This review di [...] scusses the role of salivary factors on the development of dental erosion. Material and Methods: A search was undertaken on MeDLINe website for papers from 1969 to 2010. The keywords used in the research were "saliva", "acquired pellicle", "salivary flow", "salivary buffering capacity" and "dental erosion". Inclusion of studies, data extraction and quality assessment were undertaken independently and in duplicate by two members of the review team. Disagreements were solved by discussion and consensus or by a third party. Results: Several characteristics and properties of saliva play an important role in dental erosion. Salivary clearance gradually eliminates the acids through swallowing and saliva presents buffering capacity causing neutralization and buffering of dietary acids. Salivary flow allows dilution of the acids. In addition, saliva is supersaturated with respect to tooth mineral, providing calcium, phosphate and fluoride necessary for remineralization after an erosive challenge. Furthermore, many proteins present in saliva and acquired pellicle play an important role in dental erosion. Conclusions: Saliva is the most important biological factor affecting the progression of dental erosion. Knowledge of its components and properties involved in this protective role can drive the development of preventive measures targeting to enhance its known beneficial effects.

  8. Radiation Therapy Plus Cisplatin and Gemcitabine in Treating Patients With Cervical Cancer

    Science.gov (United States)

    2014-12-23

    Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Small Cell Carcinoma; Cervical Squamous Cell Carcinoma; Stage IB Cervical Cancer; Stage IIA Cervical Cancer; Stage IIB Cervical Cancer; Stage III Cervical Cancer; Stage IVA Cervical Cancer

  9. The Expression of CD8+ and MHC-I in Cervical Cancer with HPV Infection

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    Suhartono Taat Putra

    2013-05-01

    Full Text Available Introduction: The immunity against cervical cancers is many unknown. Major histocompatability complex class I (MHC-I with the alpha domain has binding site for Cytotoxic T cells (CD8+ to target cells. The objective of this experiment is to know the expression of CD8+ and MHC-I in cervical cancer with HPV infection. Method: DNA was isolated from seventeen sample cervical cancer tissues frozen section. Diagnose related with HPV was made by PCR. Paraffin block of the tissues was cut in thoroughly cleaned cryotome and place in glass plate that covered with poly-elysine. The immuno-histochemistry is done with monoclonal antibody again MHC-I and CD8+ with TSA-indirect method. The power of expression was counted the number of positive cells to express the MHC-I and CD8+ every 100 cells per one view look. Result: The Result of this experiment shows that expression of MHC-I and CD8+ in cervical cancer with HPV infection is in mild category (30% - 70%. Conclusion: Immunity against uterine cancer played by MHC-I and CD8+ is in milt category. The experiment that related with uterine cancer immunology is suggested.

  10. Intrinsic causes of erosion.

    Science.gov (United States)

    Moazzez, Rebecca; Bartlett, David

    2014-01-01

    Gastric juice entering the mouth causes dental erosion. Common causes for the migration of gastric juice through the lower and upper oesophageal sphincters are reflux disease, laryngopharyngeal reflux, eating disorders, chronic alcoholism and pregnancy. Gastroesophageal reflux is a common condition affecting up to 65% of the Western population at some point in their lifetime. A typical clinical sign of acidic gastric juice entering the mouth is palatal dental erosion. As the condition becomes more chronic it becomes more widespread. There have been relatively few randomised studies investigating the aetiology of acids causing erosion. Of the few that have reported their findings, it appears that gastric acids have the potential to induce moderate-to-severe erosion. This literature review reports the conditions associated with the movement of gastric juice and dental erosion using medical and dental sources. PMID:24993266

  11. HYSTEROSCOPY, A MINIMALLY INVASIVE METHOD FOR DIAGNOSIS AND TREATMENT OF UTERINE INFERTILITY

    Directory of Open Access Journals (Sweden)

    Nora (Dumitriu Miron

    2011-02-01

    Full Text Available Hysteroscopy is an endoscopic procedure which consists of introducing a telescope connected to a camera through the dilated cervical canal into the uterine cavity for the visualisation of the cervical canal, uterine cavity and tubal ostiums. It is a minimally invasive method that allows diagnosis and / or treatment of a wide variety of pathologies affecting the proper functionality of internal female genitalia (menstrual and reproductive function. Objectives: It seeks to examine both the frequency and types of endouterine pathology involved in female infertility (intrauterine adhesions, fibroids, polyps, endometritis, adenomiosis. .Material and methods: The study was conducted on 161 infertile patients admitted in "Cuza Voda" Hospital, Iasi, between January 2008 - March 2010. Results: We have investigated patients aged 21-41 years (mean 31 years with primary infertility - 66 cases (40.99% and secondary infertility - 95 cases (59.01%. All patients were examined by hysteroscopy combined with laparoscopy for an infertility investigation protocol under general anaesthesia. There was no recorded incident or complication. Conclusions: Hysteroscopy proved to be a useful and relatively “easy to perform” manoeuvre in the diagnosis and treatment of endouterine pathology. It is important to note that one can identify diseases not diagnosed by ultrasound or hysterosalpingography (endometriosis and filmy adhesions.

  12. Uterine artery embolisation and magnetic resonance-guided focused ultrasound treatment of uterine fibroids

    OpenAIRE

    Sieron?, Dominik; Wiggermann, Philipp; Skupin?ski, Jaros?aw; Kukawska-sysio, Karolina; Lisek, Urszula; Koczy, Aleksandra

    2011-01-01

    Uterine fibroids are the most common benign female tumours during reproductive age. The traditional treatment for this condition is typically hysterectomy. However, there are new technologies on the rise, such as Uterine Artery Embolisation and Magnetic Resonance-guided Focused Ultrasound which are directed towards a minimally invasive or even noninvasive treatment of uterine fibroids. These modern procedures allow for a fast recovery and preservation of fertility. In this work, we presented ...

  13. Uterine vascular lesions: a rare cause of abnormal uterine bleeding, reporting of two cases

    OpenAIRE

    Sunita Arora; Rupneet Kaur; Anju Huria; Ajay Gupta

    2014-01-01

    Uterine vascular lesions in the form of arteriovenous malformation or pseudo aneurysm are rare but potential life-threatening source of bleeding. A high index of suspicion and accurate diagnosis of the condition in a timely manner are essential because instrumentation that is often used for other causes of uterine bleeding can lead to massive hemorrhage. We describe two cases of uterine vascular malformation, one presenting as postabortal hemorrhage and other as postpartum hemorrhage. Case on...

  14. Uterine artery embolisation and magnetic resonance guided focused ultrasound treatment of uterine fibroids

    International Nuclear Information System (INIS)

    Uterine fibroids are the most common benign female tumours during reproductive age. The traditional treatment for this condition is typically hysterectomy. However, there are new technologies on the rise, such as Uterine Artery Embolisation and Magnetic Resonance-guided Focused Ultrasound which are directed towards a minimally invasive or even noninvasive treatment of uterine fibroids. These modern procedures allow for a fast recovery and preservation of fertility. In this work, we presented these alternative procedures and highlighted their and limitations. (authors)

  15. Uterine Segmentation and Volume Measurement in Uterine Fibroid Patients’ MRI Using Fuzzy C-Mean Algorithm and Morphological Operations

    OpenAIRE

    Alireza Fallahi; Mohammad Pooyan; Hassan Hashemi; Hossein Ghanaati; Mohammad Ali Oghabian; Hassan Khotanlou; Madjid Shakiba; Amir Hossein Jalali; Kavous Firouznia

    2011-01-01

    Background: Uterine fibroids are common benign tumors of the female pelvis. Uterine artery embolization (UAE) is an effective treatment of symptomatic uterine fibroids by shrinkage of the size of these tumors. Segmentation of the uterine region is essential for an accurate treatment strategy.Objectives: In this paper, we will introduce a new method for uterine segmentation in T1W and enhanced T1W magnetic resonance (MR) images in a group of fibroid patients candidated for UAE in order to make...

  16. Modifications of relaxation times induced by radiation therapy in cervical carcinoma: preliminary results

    International Nuclear Information System (INIS)

    The mean T1 and T2 values for the normal uterine cervix and cervical carcinoma were evaluated. Mean spin-lattice time for carcinomas were confirmed to be higher than the mean calculated value for the normal cervix, while no significant variation was observed with respect to spin-spin time. A high individual T1 and T2 variability was noted not only in the group of patients affected by cervical carcinoma, but among the healthy subjects too. After radiation therapy a mean T1 time reduction of approximately 20% was found in cervical carcinomas compared with pretreatment measurements, whereas no difference was evident for T2 time. These preliminary results confirm that reduction in spin-lattice time is demonstrated in tumours submitted to radiation therapy. (author)

  17. Uterine artery embolization as a treatment option for uterine myomas.

    Science.gov (United States)

    Marshburn, Paul B; Matthews, Michelle L; Hurst, Bradley S

    2006-03-01

    Information is still being collected on the long-term clinical responses and appropriate patient selection for UAE. Prospective RCTs have not been performed to compare the clinical results from UAE with more conventional therapies for symptomatic uterine leiomyomata. At least three attempts at conducting such RCTs have been unsuccessful because of poor patient accrual that related to differing patient expectation and desires, clinical bias, insurance coverage, and the tendency that patients who have exhausted other treatment options may be disposed more favorably to less invasive treatments. Other comparative studies have serious limitations. For example, the retrospective study that compared outcomes after abdominal myomectomy with UAE suggested that patients who received UAE were more likely to require further invasive treatment by 3 years than were recipients of myomectomy. Lack of randomization introduced a selection bias because women in the group that underwent UAEwere older and were more likely to have had previous surgeries. A prospective study of "contemporaneous cohorts," which excluded patients who had sub-mucosal and pedunculated subserosal myomas, sought to compare quality of life measures and adverse events in patients who underwent UAE or hysterectomy. The investigators concluded that both treatments resulted in marked improvement in symptoms and quality of life scores, but complications were higher in the group that underwent hysterectomy over 1 year. In this study,however, a greater proportion of patients who underwent hysterectomy had improved pelvic pain scores. Furthermore, hysterectomy eliminates uterine bleeding and the risk for recurrence of myomas. Despite the lack of controlled studies that compared UAE with conventional surgery, and despite limited extended outcome data, UAE has gained rapid acceptance, primarily because the procedure preserves the uterus, is less invasive, and has less short-term morbidity than do most surgical options. The cost of UAE varies by region, but is comparable to the charges for hysterectomy and is less expensive than abdominal myomectomy. The evaluation before UAE may entail additional fees for diagnostic testing, such as MRI, to assess the uterine size and screen for adenomyosis. Other centers have recommended pretreatment ultrasonography, laparoscopy, hysteroscopy, endometrial biopsy, and biopsy of large fibroids to evaluate sarcoma. Generally,after UAE the recovery time and time lost from work are less; however, the potential need for subsequent surgery may be greater when compared with abdominal myomectomy. Any center that offers UAE should adhere to published clinical guidelines,maintain ongoing assessment of quality improvements measures, and observe strict criteria for obtaining procedural privileges. After McLucas advocated that gynecologists learn the skill to perform UAE for managing symptomatic myomas, the Society of Interventional Radiology responded with a precautionary commentary on the level of technical proficiency that is necessary to maintain optimum results from UAE. The complexity of pelvic arterial anatomy, the skill that is required to master modern coaxial microcatheters, and the hazards of significant patient radiation exposure were cited as reasons why sound training and demonstration of expertise be obtained before clinicians are credentialed to perform UAE.A collaboration between the gynecologist and the interventional radiologist is necessary to optimize the safety and efficacy of UAE. The primary candidates for this procedure include women who have symptomatic uterine fibroids who no longer desire fertility, but wish to avoid surgery or are poor surgical risks. The gynecologist is likely to be the primary initial consultant to patients who present with complaints of symptomatic myomas. Therefore, they must be familiar with the indications, exclusions, outcome expectations, and complications of UAE in their particular center. When hysterectomy is the only option, UAE should be considered. Appropriate diagnostic testing should ai

  18. UTILITY OF GATA3 IMMUNOHISTOCHEMISTRY IN DIFFERENTIATING UROTHELIAL CARCINOMA FROM PROSTATE ADENOCARCINOMA AND SQUAMOUS CELL CARCINOMAS OF THE UTERINE CERVIX, ANUS, AND LUNG

    OpenAIRE

    Chang, Alex; Amin, Ali; Gabrielson, Edward; Illei, Peter; Roden, Richard B.; Sharma, Rajni; Jonathan I. EPSTEIN

    2012-01-01

    Distinguishing invasive high-grade urothelial carcinoma (UC) from other carcinomas occurring in the genitourinary tract may be difficult. The differential diagnosis includes high-grade prostatic adenocarcinoma, spread from an anal squamous cell carcinoma (SCC), or spread from a uterine cervical SCC. In terms of metastatic UC, the most common problem is differentiating spread of UC to the lung versus a primary pulmonary SCC. Immunohistochemistry (IHC) for GATA binding protein 3 (GATA3), thromb...

  19. Superficial spreading squamous cell carcinoma of the uterine cervix involving the endometrium: Report of two cases with emphasis on the likely molecular mechanism

    OpenAIRE

    Ishida, Mitsuaki; Okabe, Hidetoshi

    2012-01-01

    Squamous cell carcinoma (SCC) of the cervix generally invades directly into the uterine wall, but in rare cases it spreads superficially to the inner surface of the uterus, thereby replacing the endometrium. This type is called superficial spreading SCC. In the present study we report two cases of this unusual form of cervical SCC and discuss the possible molecular mechanism involved. Two females, aged 64 (case 1) and 59 (case 2) years old, presented with post-menopausal vaginal bleeding. His...

  20. Comparative study between the hysteroscopic and histological diagnosis of patients with abnormal uterine bleeding during menacme

    Directory of Open Access Journals (Sweden)

    Reginaldo Guedes Coelho Lopes

    2006-09-01

    Full Text Available Objective: The objective of this research was to evaluate the feasibilityand the diagnostic properties of hysteroscopy in a population of womenduring menacme with the complaint of abnormal uterine bleeding,comparing endoscopic with histological findings. Methods: The studywas retrospectively conducted in 314 outpatients submitted tohysteroscopy. Every woman was submitted to guided endometrialbiopsy, using a 3 or 5mm-diameter Novak curette. The hysteroscopesused were of 3 or 5mm caliber which image was reproduced in ascreen by means of an endocamera. The results of hysteroscopic andhistological exams were compared. Results: There were noabnormalities of the uterine cavity in 151 patients (48%. Submucousmyoma was the most frequent alteration found in 45 women (14.3%.Malignancy was detected in nine patients, out of which seven hadhistological confirmation. Sensibility and specificity of hysteroscopywere respectively: a 86.3% and 75.9% for abnormal uterine cavity; b100% and 99.4% for malignancy, and c 57.7% and 88.5% for endometrialhyperplasia. Five patients (6.6% were not submitted to hysteroscopydue to cervical stenosis. Two percent of the cases presented vagalreactions, such as sweating, nausea and dizziness, with short-timerecovery. Conclusions: For higher sensitivity and specificity, diagnostichysteroscopy should be complemented with histology of theendometrial biopsy. This procedure should be considered in the workupof patients at menacme with complaints of abnormal uterinebleeding.

  1. [Fetal death beyond 14 weeks of gestation: induction of labor and obtaining of uterine vacuity].

    Science.gov (United States)

    Beucher, G; Dolley, P; Stewart, Z; Carles, G; Grossetti, E; Dreyfus, M

    2015-01-01

    The objective of this review was to assess benefits and harms of different management options for induction of labor and obtaining of uterine vacuity in case of fetal death beyond of 14 weeks of gestation. In second-trimester, the data are numerous but low methodological quality. In terms of efficiency (induction-expulsion time and uterine evacuation within 24 hours rate) and tolerance in the absence of antecedent of caesarean section, the best protocol for induction of labor in the second-trimester of pregnancy appears to be mifepristone 200mg orally followed 24-48 hours later by vaginal administration of misoprostol 200 to 400 ?g every 4 to 6 hours. In third-trimester, there is very little data. The circumstances are similar to induction of labor with living fetus. A term or near term, oxytocin and dinoprostone have a marketing authorization in this indication but misoprostol may be an alternative as the Bishop score and dose of induction of labor with living fetus. In case of previous caesarean section, the risk of uterine rupture is increased in case of a medical induction of labor with prostaglandins. The lowest effective doses should be used (100 to 200 ?g every 4 to 6 hours). Prior cervical preparation by the administration of mifepristone and possibly the use of laminar seems essential in this situation. PMID:25511016

  2. Analysis of the factors to affect uterine artery embolization for the treatment of uterine fibroid

    International Nuclear Information System (INIS)

    Objective: To observe the effect of uterine artery embolization for the treatment of uterine fibroids and analyze the influencing factors. Methods: 46 cases with symptomatic uterine myoma were treated by superselective catheterization of the bilateral uterine arteries using PVA particles. All patients were followed up for 6-9 months after uterine artery embolization to observe the improvement about symptoms and the changes of fibroid volume. The different clinical effects and the various factors were analyzed. Results: The clinical symptoms improved significantly, especially the bleeding of uterus. The average volume of fibroids decreased 45.6% in 6 months, 58.4% in 9 months after the proceduce. A lot of factors, including blood vessel anatomy, endocrine secretion, embolization technique and fibroid type can effect the clinical efficacy of uterine artery embolization for the treatment of uterine fibroids. Conclusions: Selective uterine artery embolization is a new safety and effective method for treatment of uterine myoma. Its clinical effect is correlative with a lot of factors, including blood vessel anatomy, endocrine secretion, embolization technique and fibroid type. (authors)

  3. Uterine artery embolization with Pingyangmycin lipiodol emulsion for treatment of symptomatic uterine fibroids

    International Nuclear Information System (INIS)

    Objective: To evaluate the effectiveness and side effects of uterine arterial embolization with Pingyangmycin(a homogenous bleomycin) lipiodol emulsion(PLE) for symptomatic uterine fibroids. Methods: Uterine arterial embolization with PLE was performed in 25 patients. The improvement of symptoms and uterine size changes were followed up in 3-18 months(mean 6 months) after the procedure. Results: All but 2 cases were successfully treated bilaterally. Super-selective angiography showed enlargement of uterine artery, accompanied by tortuous branches. The uterine size was increased. The uterus itself was significantly stained and emptied slowly. Coagulation necrosis was found in resected fibroids after embolization in 3 patients. One month after the procedure, a mean 40% reduction of uterine volume was obtained in 18 followed-up cases. The clinical symptoms were relieved significantly. The main side effects were hypogastric pain(13/25),which was intense in 6 cases. Conclusion: Uterine arterial embolization with PLE is a good non-surgical therapy in symptomatic uterine fibroids with mild side effects

  4. The cytological diagnosis and prognosis of malignization of cervical epithelium of uterus in pregnant women.

    Directory of Open Access Journals (Sweden)

    Sumenko V.V.

    2007-01-01

    Full Text Available The investigation is dedicated to the study of the pathological alterations of cervical epithelium of uterus, proliferative activity in the lesion focuses and the improvement of cytological diagnosis of the state of cervical epithelium of uterus. The correlation between the proliferative processes in abnormal epithelium of uterine cervix and some pathological factors of the pregnant women organism was studied. The criteria for prognosis of the cervical epithelial dysplasia in pregnant women were elaborated on this basis of our data. The pathological processes in cervical epithelium were revealed in 309 pregnant women in the first trimester (mean age of women was 26,17±0,83 years. The hormonal state of pregnant women was studied on the basis of colpocytological picture and the colpocytological types which indicate the unfavorable prognosis with a certain degree of validity were determined. The mathematic model for all cytological groups of pregnant women for prognosis of inflammatory processes, epithelial dysplasia and preinvasive cervical cancer was created. The simple and comprehensible prognostic scheme for diagnosis of epithelial dysplasia and preinvasive cervical cancer was developed.

  5. Role of diagnostic hysteroscopy in evaluation of abnormal uterine bleeding and its histopathological correlation

    Directory of Open Access Journals (Sweden)

    Kamlesh R. Chaudhari

    2014-06-01

    Methods: This is a prospective interventional study conducted in the dept. of obstetrics and gynecology at K.J. Somaiya hospital in the period between January 2010 to December 2012. Women between 20-60 years of age of any parity who presented with complaints of Abnormal Uterine Bleeding (AUB and who did not require any emergency management were enrolled in the study after excluding pregnancy, uterine/cervical infection/PID, cervical malignancy, H/o uterine perforation, patients on Oral Contraceptive Pills (OCPs, and presence of medical contraindication to any invasive procedure. A total of 98 women were included in the study. They were counselled and informed consent was taken. Patients were evaluated with detailed history, thorough examination and investigations. Hysteroscopy was done under total intravenous anaesthesia followed by endometrial biopsy. Hysteroscopic findings were then correlated with histopathology reports. Results: The sensitivity, specificity, Positive Predictive Value (PPV, Negative Predictive Value (NPV and accuracy of diagnostic hysteroscopy in the study was 98.3%, 80.5%, 89.7%, 96.7% and 91.8% respectively. For the diagnosis of endometrial hyperplasia these were 92%, 92%, 89%, 94%, and 92 % respectively. For polyp these figures were 94%, 96%, 87%, 98%, 95% respectively; for endometrial atrophy there were 66%, 95%, 60 %, 98% and 94%; for submucous fibroid 91%, 95%, 78%, 98%, and 94%; for malignancy 75%, 98%, 75%, 98%, 97% respectively. Conclusions: With the above results it can be concluded that hysteroscopy is safe, sensitive and reliable diagnostic procedure. However endometrial biopsy improves the diagnostic accuracy of hysteroscopy. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 666-670

  6. Role of carbon-11 choline PET/CT in the management of uterine carcinoma. Initial experience

    International Nuclear Information System (INIS)

    The present study was conducted to clarify the role of carbon-11 choline (11C-choline) positron emission tomography (PET)/computed tomography (CT) in the management of uterine carcinoma. Twenty-two patients who underwent 11C-choline PET/CT and pelvic MRI were evaluated retrospectively. The images were reviewed by a board-certified radiologist and a nuclear medicine specialist who were unaware of any clinical information, and a consensus was reached. Diagnostic accuracy of PET/CT was evaluated for staging. The reference standard consisted of histological examination (n=17) and follow-up conventional CT (n=5). In five patients with cervical carcinoma, 11C-choline PET/CT was performed before and after treatment that consisted of cisplatin infusion and subsequent radiotherapy. Standardized uptake value (SUV) was compared with unidimensional and volumetric measurements that were made on magnetic resonance images (MRI) before and after treatment. Based on PET/CT interpretations, the reviewers correctly classified tumor (T) stage in 8 patients (47%), nodes (N) stage in 21 patients (96%), metastasis (M) stage in 20 patients (91%), and tumor, nodes and metastasis (TNM) stage in 15 patients (88%). Tumor size, volume, and SUV decreased after treatment in five patients with cervical carcinoma. Using the Pearson correlation test, a significant correlation was found between the reduction rate of SUV and reduction rate of tumor volume. 11Cction rate of tumor volume. 11C-choline PET/CT is an accurate means for the management of patients with uterine carcinoma. The combination of 11C-choline PET/CT and MRI increases the accuracy of staging in patients with uterine carcinoma. (author)

  7. Cervical perineural cyst masquerading as a cervical spinal tumor.

    Science.gov (United States)

    Joshi, Vijay P; Zanwar, Atul; Karande, Anuradha; Agrawal, Amit

    2014-04-01

    Tarlov (perineural) cysts of the nerve roots are common and usually incidental findings during magnetic resonance imaging of the lumbosacral spine. There are only a few case reports where cervical symptomatic perineural cysts have been described in the literature. We report such a case where a high cervical perineural cyst was masquerading as a cervical spinal tumor. PMID:24761204

  8. Cervical Perineural Cyst Masquerading as a Cervical Spinal Tumor

    Science.gov (United States)

    Joshi, Vijay P; Zanwar, Atul; Karande, Anuradha

    2014-01-01

    Tarlov (perineural) cysts of the nerve roots are common and usually incidental findings during magnetic resonance imaging of the lumbosacral spine. There are only a few case reports where cervical symptomatic perineural cysts have been described in the literature. We report such a case where a high cervical perineural cyst was masquerading as a cervical spinal tumor. PMID:24761204

  9. Sets resilient to erosion

    CERN Document Server

    Pegden, Wesley

    2011-01-01

    The erosion of a set in Euclidean space by a radius r>0 is the subset of X consisting of points at distance >/-r from the complement of X. A set is resilient to erosion if it is similar to its erosion by some positive radius. We give a somewhat surprising characterization of resilient sets, consisting in one part of simple geometric constraints on convex resilient sets, and, in another, a correspondence between nonconvex resilient sets and scale-invariant (e.g., 'exact fractal') sets.

  10. Will MR image-guided brachytherapy be a standard of care for cervical cancer in future? An Indian perspective

    International Nuclear Information System (INIS)

    Cancer of the uterine cervix is the leading cancer among the female population in India. Radical external chemoradiotherapy and brachytherapy is the treatment of choice for locally advanced cervical cancers. Brachytherapy plays a pivotal role for its ability to deliver very high dose to the tumor while reducing the dose to the surrounding critical organs. In the last decade, external beam radiotherapy (EBRT) has seen technological advances in terms of intensity modulated radiotherapy (IMRT), image guided radiotherapy (IGRT), etc. However, the advances in brachytherapy for cervical cancers are not as rapid as EBRT, which have shown significant potential to improve local control rates and reduce toxicities

  11. Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma

    Directory of Open Access Journals (Sweden)

    Fukushima Masanori

    2009-02-01

    Full Text Available Abstract Background Lymph node dissection has proven prognostic benefits for patients with ovarian or uterine carcinoma; however, one of the complications associated with this procedure is lymphedema. We aimed to identify the factors that are associated with the occurrence of lymphedema after lymph node dissection for the treatment of ovarian or uterine carcinoma. Methods A total of 694 patients with histologically confirmed ovarian (135 patients or uterine cancer (258 with cervical cancer, 301 with endometrial cancer who underwent lymph node dissection were studied retrospectively. Logistic regression analyses were used to identify the risk factors associated with occurrence of lymphedema. Results Among ovarian and uterine cancer patients who underwent pelvic lymph node dissection, post-operative radiotherapy (odds ratio: 1.79; 95% confidence interval: 1.20–2.67; p = 0.006 was statistically significantly associated with occurrence of lymphedema. Conclusion There was no relationship between any surgical procedure and occurrence of lymphedema among patients undergoing pelvic lymphadenectomy. Our findings are supported by a sound biological rationale because they suggest that limb lymphedema is caused by pelvic lymph node dissection.

  12. Embarazo ectópico cervical tratado con metotrexate: Reporte de un caso Ectopic cervical pregnancy treated with methotrexate: A case report

    Directory of Open Access Journals (Sweden)

    Rodolfo Valentín Martínez Camilo

    2000-08-01

    Full Text Available Se presenta el caso de una paciente con embarazo ectópico cervical, a quien se le administró metotrexate sistémico como alternativa al tratamiento quirúrgico. La terapia medicamentosa consistió en la administración de 50 mg de metotrexate por vía endovenosa en días alternos, en un total de 4 dosis, así como el uso de ácido fólico por vía oral a razón de 1 tableta de 5 mg cada 12 horas, en los días en que no se administró metotrexate. Se controló el caso con láminas periféricas evolutivas y ultrasonografía. Se confirmó la destrucción del embarazo por resultados histológicos. Se considera que en el embarazo ectópico cervical, el uso de metotrexate puede ser utilizado como tratamiento conservador. El embarazo ectópico es una afección muy importante en Ginecología,¹ y constituye una entidad en que el óvulo fecundado se implanta en otro sitio que no es la cavidad uterina.² El embarazo cervical es una forma rara de embarazo ectópico, donde el huevo se implanta en el canal cervical y lo distiende a medida que crece.3,4 La hemorragia indolora es su característica clínica habitual5 y al examen físico se observa un cérvix hipertrófico muy vascularizado, con un tejido que sobresale por el orificio externo.6 Como complementario útil para el diagnóstico se puede usar la ultrasonografía, en la que se demuestra de forma directa la presencia de un saco gestacionalThe case of a patient with ectopic cervical pregnancy that was systematically administered methotrexate as an alternative to surgical treatment is presented. Drug therapy consisted in the administration of 4 doses of. 50 mg of methotrexate by endovenous route every other day. Patients received folic acid at doses of 1 tablet of 500 mg every 12 hours when methotrexate was not administered. The case was controlled with evolutive peripheral plates and ultrasonography. The destruction of pregnancy was confirmed by histological results. It is considered that methotrexate may be used as a conservative treatment in ectopic cervical pregnancy. Ectopic pregnancy is a very important affection in Gynecology,¹ and it is an entity where the fecundated ovum is not implanted in the uterine cavity but in another site.² Cervical pregnancy is a rare form of ectopic pregnancy, in which the egg is implanted in the cervical canal and causes its distension as it grows.3, 4 Painless hemorrhage is its habitual clinical characteristic5 and on the physical examination it is observed a very vascularized hypertrophic cervix with a tissue that surpasses the external orifice.6 Ultrasonography may be used as a useful complementary diagnostic tool to show directly the presence of a gestational sac.

  13. Invasive cervical resorption: treatment challenges

    OpenAIRE

    Kim, Yookyung; Lee, Chan-young; Kim, Euiseong; Roh, Byoung-duck

    2012-01-01

    Invasive cervical resorption is a relatively uncommon form of external root resorption. It is characterized by invasion of cervical region of the root by fibrovascular tissue derived from the periodontal ligament. This case presents an invasive cervical resorption occurring in maxillary lateral incisor, following damage in cervical cementum from avulsion and intracoronal bleaching procedure. Flap reflection, debridement and restoration with glass ionomer cement were performed in an attempt to...

  14. Deep cervical infection?

    Directory of Open Access Journals (Sweden)

    Bernardo T

    2012-06-01

    Full Text Available Introduction: Inflammatory cervical swelling may have several causes. The jugular vein thrombosis is a rare entity, often forgotten. Most frequently arises due to a cervical sepsis by the use of a central venous catheter or intravenous drug abuse (drug addicts. Rarely, is secondary to a hypercoagulability state associated with a visceral carcinoma (Trousseau Syndrome. Material and Methods: The authors present the case of a 65 years old male, who used the ENT Emergency Service due to a painful left cervical swelling with local and systemic inflammatory signs of 3 days duration. Results: An cervical ultrasound suggested a neck abscess. CT was performed and confirmed the ultrasound results. Because of its location in the path of the internal jugular vein, we requested re-evaluation by CT with intravenous contrast and doppler ultrasound, obtaining the diagnosis of thrombosis of the internal jugular vein. Further studies were conduct to clarify the hypercoagulability state, since the patient had no known predisposing factor. Finally the diagnosis of unresectable gastric carcinoma was made. Discussion and Conclusion: The ENT must be aware and be able to understand any cervical imagiologic studies. A deep knowledge of the anatomical imagiología is important for the diagnosis of jugular thrombosis. When we have a case of spontaneous jugular thrombosis, we must look for possible visceral carcinoma.

  15. Abnormal uterine bleeding: a clinicohistopathological analysis

    OpenAIRE

    Anupamasuresh Y; Suresh YV; Prachi Jain

    2014-01-01

    Background: Abnormal uterine bleeding (AUB) is one of the most common problem for the patients and the gynecologists. It adversely effects on the quality of life and psychology of women. It is of special concern in developing country as it adds to the causes of anemia. Management of Abnormal Uterine Bleeding (AUB) is not complete without tissue diagnosis especially in perimenopausal and post-menopausal women. Histological characteristics of endometrial biopsy material as assessed by light mic...

  16. Outcomes following unilateral uterine artery embolisation.

    Science.gov (United States)

    McLucas, B; Reed, R A; Goodwin, S; Rappaport, A; Adler, L; Perrella, R; Dalrymple, J

    2002-02-01

    Uterine artery embolisation has been described as successful only when both arteries are embolised. However, results in patients with one congenitally absent or previously ligated artery are unknown. Women suffering from symptomatic uterine myomata were treated at a university teaching hospital, a community hospital and an outpatient surgery centre. Retrospective review of patient response to embolisation was assessed by chart review and questionnaire. Uterine and dominant fibroid size response was assessed by comparing pre- and post-embolisation ultrasound examinations. This study analysed three patient groups within the general population: those who underwent unilateral embolisation because of technical failure, those who ultimately underwent bilateral embolisation after initial technical failure and those who underwent unilateral embolisation because of an absent uterine artery. 12 patients underwent unilateral embolisation, 4 of whom underwent this procedure because of an absent uterine artery. Three of these four patients had a congenitally absent uterine artery arising from the internal iliac artery and all three experienced successful outcomes. The fourth patient had a previously ligated internal iliac artery and her symptoms worsened after the procedure. Eight patients had unilateral embolisation due to technical failure. Five of these patients underwent a subsequent procedure during which the contralateral uterine artery was embolised. Four of these five patients had successful outcomes and one was lost to follow-up. Another of the eight patients suffered an arterial injury leading to technical failure, and was lost to follow-up. Of the two remaining patients with unilateral technical failure, only one had a successful outcome. This study concluded that patients who undergo unilateral embolisation for technical reasons should be offered a second embolisation procedure shortly after the initial procedure. Patients with a congenitally absent uterine artery may respond with similar success to those who underwent bilateral embolisation. In contrast, the patient with a previously ligated internal iliac artery failed. The numbers in this study are too small for statistical analysis and subsequent studies should be performed to confirm these findings. PMID:11893635

  17. Mifepristone for preoperative treatment of uterine leiomyoma

    OpenAIRE

    Engman, Mikael

    2011-01-01

    AIM: To explore the clinical impact and its molecular regulation on uterine leiomyomas in preoperative treatment with mifepristone, a progesterone receptor modulator (PRM). BACKGROUND: Uterine leiomyomas are highly prevalent in fertile women, increasing with age up to 35-50 % in a population approaching the age of 50. These most often benign tumors, frequently cause menorrhagia, and may interfere with fertility and the outcome of pregnancy. Progesterone and estrogen have a role in leiom...

  18. Advances in the management of uterine fibroids

    OpenAIRE

    Munro, Kirsty I.; Critchley, Hilary Od

    2009-01-01

    Uterine fibroids are extremely common, with major surgery the current main management option; uterine artery embolisation is an alternative, but risks to fertility are unclear. Minimally invasive procedures are becoming more commonly performed via both the hysteroscope and laparoscope, minimising recovery time for patients. Recently, small doses of progesterone receptor modulators (mifepristone and asoprisnil) have been shown to be effective in reducing menstrual blood loss and fibroid size. ...

  19. Detection of Merkel cell polyomavirus in cervical squamous cell carcinomas and adenocarcinomas from Japanese patients

    Directory of Open Access Journals (Sweden)

    Imajoh Masayuki

    2012-08-01

    Full Text Available Abstract Background Merkel cell polyomavirus (MCPyV was identified originally in Merkel cell carcinoma (MCC, a rare form of human skin neuroendocrine carcinoma. Evidence of MCPyV existence in other forms of malignancy such as cutaneous squamous cell carcinomas (SCCs is growing. Cervical cancers became the focus of our interest in searching for potentially MCPyV-related tumors because: (i the major histological type of cervical cancer is the SCC; (ii the uterine cervix is a common site of neuroendocrine carcinomas histologically similar to MCCs; and (iii MCPyV might be transmitted during sexual interaction as demonstrated for human papillomavirus (HPV. In this study, we aimed to clarify the possible presence of MCPyV in cervical SCCs from Japanese patients. Cervical adenocarcinomas (ACs were also studied. Results Formalin-fixed paraffin-embedded tissue samples from 48 cervical SCCs and 16 cervical ACs were examined for the presence of the MCPyV genome by polymerase chain reaction (PCR and sequencing analyses. PCR analysis revealed that 9/48 cervical SCCs (19% and 4/16 cervical ACs (25% were positive for MCPyV DNA. MCPyV-specific PCR products were sequenced to compare them with reference sequences. The nucleotide sequences in the MCPyV large T (LT-sequenced region were the same among MCPyV-positive cervical SCCs and AC. Conversely, in the MCPyV viral protein 1 (VP1-sequenced region, two cervical SCCs and three cervical ACs showed several nucleotide substitutions, of which three caused amino acid substitutions. These sequencing results suggested that three MCPyV variants of the VP1 were identified in our cases. Immunohistochemistry showed that the LT antigen was expressed in tumor cells in MCPyV-positive samples. Genotyping of human HPV in the MCPyV-positive samples revealed that infected HPVs were HPV types 16, 31 and 58 for SCCs and HPV types 16 and 18 for ACs. Conclusions This study provides the first observation that MCPyV coexists in a subset of HPV-associated cervical cancers from Japanese patients. The prevalence of MCPyV in these lesions was close to that observed in the cutaneous SCCs. Further worldwide epidemiological surveys are warranted to determine the possible association of MCPyV with pathogenesis of cervical cancers.

  20. Neglected case of uterine leiomyoma: Case report

    Directory of Open Access Journals (Sweden)

    Nin?i? Dejan

    2008-01-01

    Full Text Available Introduction. Uterine leimyomas are the most common gynaecologacal tumors and represent 30% of all benign gynecological tumors. The vast majority of leiomyomas are asymptomatic and do not need to be treated. Pelvic pain and abnormal uterine bleeding should be considered as the most important reasons for surgical treatment of uterine fibroids. Case report. A female patient, age 69, was treated at the Institute of Oncology in Sremska Kamenica because of a huge abdominal tumor. Major symptoms were increased body temperature, abnormal uterine bleeding and extensive abdominal enlargement. After the clinical, laboratory and imaging evaluation, the offered hysterectomy was performed. The evacuated tumor was 18 kg heavy and 40 cm in length. The pathohystological diagnosis was leiomyoma per magnum. The patient was released after 11 days of hospitalization without any postoperative complications and in good general condition. Discussion. Uterine fibroids can be managed medically and surgically. Hysterectomy should be performed in every case with dominant symptoms like abnormal uterine bleeding, tumor growth and increasing abdominal pain (when other causes are excluded in postmenopausal women. This particular case is an example of low general and health culture of the reported patient and maybe caused by fear from medical and surgical treatment. Sometimes, making a diagnosis of the nature of pelvic tumor is very hard, but by respecting diagnostic procedure an adequate treatment of those patients can be ensured.

  1. Uterine sarcomas: clinical presentation and MRI features.

    Science.gov (United States)

    Santos, Pedro; Cunha, Teresa Margarida

    2015-01-01

    Uterine sarcomas are a rare heterogeneous group of tumors of mesenchymal origin, accounting for approximately 8% of uterine malignancies. They comprise leiomyosarcoma, endometrial stromal sarcoma, undifferentiated endometrial sarcoma, and adenosarcoma. Compared with the more common endometrial carcinomas, uterine sarcomas behave more aggressively and are associated with a poorer prognosis. Due to their distinct clinical and biological behavior, the International Federation of Gynecology and Obstetrics introduced a new staging system for uterine sarcomas in 2009, categorizing uterine carcinosarcoma as a variant of endometrial carcinoma, rather than a pure sarcoma. Magnetic resonance imaging (MRI) has a developing role in the assessment of these malignancies. Features such as tumor localization, irregular or nodular margins, necrosis, rapid growth, intense contrast enhancement, and restriction at diffusion-weighted imaging can suggest the diagnosis and help differentiate from more common leiomyomas and endometrial carcinoma. MRI is therefore extremely useful in preoperative detection and staging and, consequently, in determination of appropriate management. This pictorial review aims to discuss the clinical features of uterine sarcomas, as well as their most common appearances and distinct characteristics in MRI. PMID:25347940

  2. Sodium cavitation erosion testing

    International Nuclear Information System (INIS)

    This paper discusses the consideration leading to the definition and execution of sodium cavitation erosion tests, and describes the first two tests run with 4000C sodium in the cavitation tunnel at the CADARACHE Nuclear Research Center

  3. Naked Dirt: Erosion

    Science.gov (United States)

    This file explains that the United States Department of Agriculture developed the Universal Soil Loss Equation (revised in 1993 to RUSLE) to help farmers, landscapers, and architects decide how to prevent erosion. The equation predicts the rate of erosion for a site based on the annual rainfall, soil type, and degree of slope. The site includes a table that shows how different practices affect erosion rates. It explains that sediment pollution makes swimming and boating less fun, clogs city drinking water systems, fills in lakes, and smothers fish and insect habitat. Sediments often float awhile before settling out, making water cloudy or turbid. There is an explanation of which native grasses are best for holding the soil in place and other suggestions to stop erosion.

  4. Impact of MRI in the management and staging of cancer of the uterine cervix

    Energy Technology Data Exchange (ETDEWEB)

    Stenstedt, Kristina (Centre of Surgical Gastroenterology, Karolinska Univ. Hospital and Karolinska Inst., Stockholm (Sweden)); Hellstroem, Ann-Cathrin (Dept. of Gynecological Oncology, Radiumhemmet, Karolinska Univ. Hospital and Karolinska Inst., Stockholm (Sweden)); Fridsten, Susanne; Blomqvist, Lennart (Dept. of Diagnostic Radiology Karolinska Univ. Hospital and Karolinska Inst., Stockholm (Sweden))

    2011-04-15

    Background. Cervical carcinoma is the only gynecological tumor still being staged mainly by clinical examination and only a limited use of diagnostic radiology. Cross sectional imaging is increasingly used as an aid in the staging procedure. We wanted to assess the impact of magnetic resonance imaging (MRI) in addition to the clinical staging of patients with carcinoma of the uterine cervix. Material and methods. A retrospective single-centre analysis of 183 women referred to a tertiary referral centre for gynecological tumors (<= 65 years old) with cervical cancer diagnosed between January 1, 2003 and December 31, 2006 who have undergone an MRI investigation before start of treatment. Patient records were retrospectively reviewed and any change of the planned treatment after the MRI examination was noted. Results. In patients with cervical carcinoma FIGO stage Ia2-IIa treated surgically, the treatment plan was altered due to MRI results in 10/125 patients. In the smaller group of patients with clinically more advanced disease receiving radio-chemotherapy, the treatment plan was altered in 12/58 patients. Reasons for changing the treatment plan after MRI were findings indicating a higher (n = 8) or lower (n = 5) local tumor stage, findings of para aortic nodal disease (n = 4) or difficulty to clinically examine the patient due to obesity (n = 2). MRI was also an aid in deciding whether or not to offer fertility preserving treatment in three cases. Conclusion. The use of MRI affects treatment planning in patients with cancer of the uterine cervix. The impact is more obvious in more advanced stages of disease and in patients who are difficult to examine clinically due to, for example body constitution. The result of MRI is also an aid in deciding whether or not a fertility preserving operation is feasible

  5. Impact of MRI in the management and staging of cancer of the uterine cervix

    International Nuclear Information System (INIS)

    Background. Cervical carcinoma is the only gynecological tumor still being staged mainly by clinical examination and only a limited use of diagnostic radiology. Cross sectional imaging is increasingly used as an aid in the staging procedure. We wanted to assess the impact of magnetic resonance imaging (MRI) in addition to the clinical staging of patients with carcinoma of the uterine cervix. Material and methods. A retrospective single-centre analysis of 183 women referred to a tertiary referral centre for gynecological tumors (? 65 years old) with cervical cancer diagnosed between January 1, 2003 and December 31, 2006 who have undergone an MRI investigation before start of treatment. Patient records were retrospectively reviewed and any change of the planned treatment after the MRI examination was noted. Results. In patients with cervical carcinoma FIGO stage Ia2-IIa treated surgically, the treatment plan was altered due to MRI results in 10/125 patients. In the smaller group of patients with clinically more advanced disease receiving radio-chemotherapy, the treatment plan was altered in 12/58 patients. Reasons for changing the treatment plan after MRI were findings indicating a higher (n = 8) or lower (n = 5) local tumor stage, findings of para aortic nodal disease (n = 4) or difficulty to clinically examine the patient due to obesity (n = 2). MRI was also an aid in deciding whether or not to offer fertility preserving treatment in three cases. Conclusion. The usement in three cases. Conclusion. The use of MRI affects treatment planning in patients with cancer of the uterine cervix. The impact is more obvious in more advanced stages of disease and in patients who are difficult to examine clinically due to, for example body constitution. The result of MRI is also an aid in deciding whether or not a fertility preserving operation is feasible

  6. Dune erosion above revetments:

    OpenAIRE

    J.S.M. Van Thiel de Vries

    2012-01-01

    In a situation with a narrow dune, the dune base can be protected with a revetment to reduce dune erosion during extreme events. To quantify the effects of a revetment on storm impact, the functionality of the numerical storm impact model XBeach (Roelvink et al., 2009) is extended to account for the complex morphodynamics around revetments. Here the focus is on dune erosion above revetments, which is simulated with a simple avalanching algorithm that is triggered by the combined runup of shor...

  7. Actinides, accelerators and erosion

    OpenAIRE

    Fifield L. K.; Tims S.G.

    2012-01-01

    Fallout isotopes can be used as artificial tracers of soil erosion and sediment accumulation. The most commonly used isotope to date has been 137Cs. Concentrations of 137Cs are, however, significantly lower in the Southern Hemisphere, and furthermore have now declined to 35% of original values due to radioactive decay. As a consequence the future utility of 137Cs is limited in Australia, with many erosion applications becoming untenable within the next 20 years, and there is a need to replace...

  8. Effect of different curvature fletcher of uterine tube on the dose of nomal organs around uterus

    International Nuclear Information System (INIS)

    Objective: To study effect of different curvature Fletcher of uterine tube on the dose of major organs around uterus. The experimental data was provided to help doctors choose suitable Fletcher of uterine tube in afterloading treatment. Methods: Fletcher of uterine tubes produced by Netherlands Nucletron Company had three kinds of curvature (15 degree, 30 degree, 45 degree). We chose three clinical common treated lengths (4 cm, 6 cm, 8 cm). These end points of three lengths of each tube were assumed at cervical orifice, The afterloading plans were designed by Nucletron GENIE TPS (V1.0), we recorded the coordinate and time of all dwelling points. Then anthropomorphic pelvic phantom was scanned by GE LightSpeed16 CT machine and the CT images were transferred to 3D visual after-loading brachytherapy simulating planning system (3DV-TPS). According the coordinate and time of all dwelling points from GENIE TPS, 3DV-TPS rebuilt the dose distribution of three lengths of each tubes. The absorbed dose of some nomal organs in different treatment condition was got from same coordinate. Results: Even if the treated length of three tubes is same, the absorbed dose of some nomal organ was different, the difference of absorbed dose of bladder is biggest (13%-89%). bladder center (4%-38%), rectum (1%-12%), A point (1%-6%), B point (6%-16%), F point (4%-25%), ge outside lymph node (1%-13%), ge total lymph node (2%-16%), ovary (5%-18%), femur (3%-22%). Conclusion: It is necessary to car%-22%). Conclusion: It is necessary to carefully choose suitable Fletcher of uterine tube before the afterloading treatment. (authors)

  9. Laminin-5 is a biomarker of invasiveness in cervical adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Imura Johji

    2012-08-01

    Full Text Available Abstract Background Glandular lesions are often problematic for diagnostic cervical pathology. The survival of patients with adenocarcinoma is significantly poorer than that of patient with squamous cell carcinoma. One reason for this increased risk is the aggressive invasiveness of adenocarcinoma. Therefore additional biomarkers, to supplement morphological diagnosis of adenocarcinoma, are necessary. We have assessed the diagnostic utility of Laminin-5 (Laminin ?2 chain: Lam-5 in the diagnosis of the invasiveness of cervical adenocarcinoma and related glandular lesions. Methods Lam-5 immunohistochemistry was performed on archival specimens from 8 patients with uterine leiomyoma as a negative control group, 6 patients with endocervical gland hyperplasia, 6 patients with adenocarcinoma in situ, 6 patients with microinvasive adenocarcinoma and 24 patients with invasive adenocarcinoma. Results The expression of Lam-5 was not detected in normal mucosa, but was seen along the basement membrane in endocervical gland hyperplasia and adenocarcinoma in situ and was observed in the cytoplasm of tumor cells in microinvasive and invasive adenocarcinoma. Conclusion We conclude that Lam-5 is a useful biomarker in the evaluation of invasiveness in cervical adenocarcinoma. Virtual slides The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7316562925827381

  10. Slurry erosion. STP 946

    Energy Technology Data Exchange (ETDEWEB)

    Miller, J.E.; Schmidt, F.E. Jr. (Eds.)

    1984-01-01

    This volume introduces the growth of a new industry and the need for testing. Papers cover four major areas of concern: 1. Materials; 2. Process (Fuel) Slurries; 3. Applications; 4. Test Methods. The topics covered are: abrasive wear under wet sliding conditions; four coatings tested for abrasion and erosion performance in silica sand and in Alundum slurries; relative erosivity for coal-water, coal-oil, and petroleum coke-oil slurries; an investigation of the erosivity of particles of several different coals and respective vacuum bottoms from the Exxon Donor Solvent (EDS) coal liquefaction pilot plant of the Exxon Coal Liquefaction Process (ECLP); corrosion and erosion in the limestone slurry scrubber module; slurry erosion-corrosion tests on metallic materials of practical use by both a vibratory apparatus and a jet-in-slit apparatus; a new flow-through slurry test developed by the Bureau of Mines; test devices to simulate erosion wear by friction and impact in dense slurry flow; hydraulic transportation of slurries for short-distance.

  11. Radiation effects on DNA content of cervical cancer cells: A rapid evaluation of radiation sensitivity by laser scanning cytometry

    OpenAIRE

    Fujiyoshi, Naoki; Ushijima, Kimio; Kawano, Kouichiro; Fujiyoshi, Keizo; Yamaguchi, Tomohiko; Araki, Yuko; Kakuma, Tatsuyuki; Watanabe, Sumiko; Kaku, Tsunehisa; Nishida, Takashi; Kamura, Toshiharu

    2014-01-01

    Since uterine cervical cancer is regarded as a radiosensive tumor, ionizing radiation is the most frequently used treatment modality against the disease. Although the crucial end-point is radiation-induced cell death, the tumors are not equally sensitive to radiation. Determining the criteria that may be used to predict tumor radiosensitivity is of importance; however, little success has been achieved thus far. In radioresistant cases the therapeutic strategy should be changed, thereby avoidi...

  12. Image-based intracavitary brachytherapy in the treatment of inoperable uterine cancer: individualized dose specification

    International Nuclear Information System (INIS)

    With advances in imaging studies, dose specification of uterine cancer can be defined at the specific sites such as the myometrium or the serosal surface rather than arbitutary points or mghrs. This report presents our experience with image-based brachytherapy for inoperable uterine cancer. Seven patients with organ-confined uterine cancer (2 stage I G1, 2 stage I G2, 3 stage 1 G3) underwent definitive radiation therapy due to poor medical condition. All of the patients underwent a CT or MRI scan of the pelvis prior to intracavitary application. Based on the size of the uterine cavity, a single channel intrauterine applicator was selected for a small uterus and a multiple channel intrauterine applicator was used for a larger uterus as well as colpostats in the upper vagina. All of the patients underwent cervical dilation and insertion of intrauterine device under the guidance of real-time ultrasound in the operating room. A CT or MRI scan of the pelvis was performed with the applicator in place in addition to orthogonal pelvic films. Dose specification was 75 Gy to the mid-myometrium and less than 50 Gy to the serosal surface of the uterus. Three patients with stage I G1-2 disease had intracavitary brachytherapy alone. Four patients with stage I G2-3 disease were treated with a combination of external pelvic radiation and intracavitary brachytherapy. Five patients had low-dose rate brachytherapy and two patients had high-dose rate brachytherapy. Five patients had a sirate brachytherapy. Five patients had a single channel intrauterine brachytherapy and two patients had multiple channel brachytherapy. Based on the CT or MRI measurements of the uterine wall thickness, 75Gy was prescribed at 1.5 cm from the midline of the uterus in 4 patients and at 2.0 cm in 3 patients. The medium follow-up time after radiation treatment was 23 months. Five patients are alive without evidence of disease and two patients died of other causes. All patients had local control without major side effects. Image-based brachytherapy can be done easily and provide an individualized dose specification for inoperable uterine cancer with good local control

  13. CERVICAL NECROTIZING FASCIITIS

    Directory of Open Access Journals (Sweden)

    G. Dimofte

    2009-05-01

    Full Text Available Cervical necrotizing fasciitis is an unusual encounter in the general surgical practice, but is a life-threatening condition requiring early recognition and adequate surgical treatment. We present the case of a 65 year old male patient referred to our department from a General Hospital. Large excisions of both superficial and deep cervical fascia were required together with necrotic skin on a very large surface. Rapid recovery with early sterilization allowed adequate skin grafting with good results. We advocate for aggressive debridment with excision in viable healthy tissue, with no concern for the future reconstruction followe by early grafting of the skin defect.

  14. Uterine Artery Embolization to Treat Uterine Adenomyosis with or without Uterine Leiomyomata: Results of Symptom Control and Health-Related Quality of Life 40 Months after Treatment

    International Nuclear Information System (INIS)

    Purpose: To evaluate the clinical outcome for uterine adenomyosis with or without uterine leiomyomata 40 months after uterine artery embolization (UAE). Methods: Forty women aged 39–56 years (median 46 years) with symptomatic uterine adenomyosis and magnetic resonance imaging findings of uterine adenomyosis with or without combined uterine leiomyomata underwent UAE. Self-perceived changes in clinical symptoms were assessed, and residual symptom severity and health-related quality of life (HRQOL) after UAE were evaluated. Clinical failure was defined as no symptomatic improvement or second invasive therapy after UAE. Results were stratified by the extent of uterine adenomyosis at baseline magnetic resonance imaging. Results: Patients were followed for a median of 40 months (range 5–102 months). UAE led to symptomatic control after UAE in 29 (72.5%) of 40 patients while 11 women underwent hysterectomy (n = 10) or dilatation and curettage (n = 1) for therapy failure. No significant difference between women with pure uterine adenoymosis and women with uterine adenomyosis combined with uterine leiomyomata was observed. Best results were shown for UAE in uterine adenomyosis with uterine leiomyomata predominance as opposed to predominant uterine adenomyosis with minor fibroid disease (clinical failure 0% vs. 31.5%, P = 0.058). Throughout the study group, HRQOL score values increased and symptom severity scores decreased after UAE. Least improvement was noted for women wiast improvement was noted for women with pure adenomyosis. Conclusions: UAE is clinically effective in the long term in most women with uterine adenomyosis. Symptomatic control and HRQOL were highest in patients with combined disease of uterine adenomyosis but leiomyomata predominance.

  15. Clinical prevention and treatment for pain aroused by uterine arterial embolization for uterine myomata

    International Nuclear Information System (INIS)

    Objective: To study the treatment methods of pain aroused by uterine arterial embolization (UAE) for uterine myomata. Methods: Fifty six cases of uterine myomata were undertaken with UAE. After embolization, pain occurred in each case. According to the treatment methods for pain, 56 cases were divided into 2 groups: group A (symptomatic treatment, 31 cases) and group B (preventive treatment, 25 cases). The degrees and durations of pain were analyzed separately in two groups. Results: The clinical symptoms and signs were almost disappeared in two groups after more than 6 months follow up. The degrees of pain in each group showed no significant difference, P>0.05, but the duration of pain was different in group A and B, P<0.05. Conclusions: The active proper effective prompt and preventive treatment could reduce the degree and duration of pain, and elevate the integrated curative effects of uterine arterial embolization for uterine myomata

  16. Determining inter-fractional motion of the uterus using 3D ultrasound imaging during radiotherapy for cervical cancer

    DEFF Research Database (Denmark)

    Baker, Mariwan; Jensen, JØrgen Arendt

    2014-01-01

    Uterine positional changes can reduce the accuracy of radiotherapy for cervical cancer patients. The purpose of this study was to; 1) Quantify the inter-fractional uterine displacement using a novel 3D ultrasound (US) imaging system, and 2) Compare the result with the bone match shift determined by Cone-Beam CT (CBCT) imaging.Five cervical cancer patients were enrolled in the study. Three of them underwent weekly CBCT imaging prior to treatment and bone match shift was applied. After treatment delivery they underwent a weekly US scan. The transabdominal scans were conducted using a Clarity US system (Clarity® Model 310C00). Uterine positional shifts based on soft-tissue match using US was performed and compared to bone match shifts for the three directions. Mean value (±1 SD) of the US shifts were (mm); anterior-posterior (A/P): (3.8±5.5), superior-inferior (S/I) (-3.5±5.2), and left-right (L/R): (0.4±4.9). The variations were larger than the CBCT shifts. The largest inter-fractional displacement was from -2 mm to +14 mm in the AP-direction for patient 3. Thus, CBCT bone matching underestimates the uterine positional displacement due to neglecting internal uterine positional change to the bone structures. Since the US images were significantly better than the CBCT images in terms of soft-tissue visualization, the US system can provide an optional image-guided radiation therapy (IGRT) system. US imaging might be a better IGRT system than CBCT, despite difficulty in capturing the entire uterus. Uterine shifts based on US imaging contains relative uterus-bone displacement, which is not taken into consideration using CBCT bone match.

  17. Determining inter-fractional motion of the uterus using 3D ultrasound imaging during radiotherapy for cervical cancer

    Science.gov (United States)

    Baker, Mariwan; Jensen, Jørgen Arendt; Behrens, Claus F.

    2014-03-01

    Uterine positional changes can reduce the accuracy of radiotherapy for cervical cancer patients. The purpose of this study was to; 1) Quantify the inter-fractional uterine displacement using a novel 3D ultrasound (US) imaging system, and 2) Compare the result with the bone match shift determined by Cone- Beam CT (CBCT) imaging.Five cervical cancer patients were enrolled in the study. Three of them underwent weekly CBCT imaging prior to treatment and bone match shift was applied. After treatment delivery they underwent a weekly US scan. The transabdominal scans were conducted using a Clarity US system (Clarity® Model 310C00). Uterine positional shifts based on soft-tissue match using US was performed and compared to bone match shifts for the three directions. Mean value (+/-1 SD) of the US shifts were (mm); anterior-posterior (A/P): (3.8+/-5.5), superior-inferior (S/I) (-3.5+/-5.2), and left-right (L/R): (0.4+/-4.9). The variations were larger than the CBCT shifts. The largest inter-fractional displacement was from -2 mm to +14 mm in the AP-direction for patient 3. Thus, CBCT bone matching underestimates the uterine positional displacement due to neglecting internal uterine positional change to the bone structures. Since the US images were significantly better than the CBCT images in terms of soft-tissue visualization, the US system can provide an optional image-guided radiation therapy (IGRT) system. US imaging might be a better IGRT system than CBCT, despite difficulty in capturing the entire uterus. Uterine shifts based on US imaging contains relative uterus-bone displacement, which is not taken into consideration using CBCT bone match.

  18. Rainfall erosivity in Europe.

    Science.gov (United States)

    Panagos, Panos; Ballabio, Cristiano; Borrelli, Pasquale; Meusburger, Katrin; Klik, Andreas; Rousseva, Svetla; Tadi?, Melita Per?ec; Michaelides, Silas; Hrabalíková, Michaela; Olsen, Preben; Aalto, Juha; Lakatos, Mónika; Rymszewicz, Anna; Dumitrescu, Alexandru; Beguería, Santiago; Alewell, Christine

    2015-04-01

    Rainfall is one the main drivers of soil erosion. The erosive force of rainfall is expressed as rainfall erosivity. Rainfall erosivity considers the rainfall amount and intensity, and is most commonly expressed as the R-factor in the USLE model and its revised version, RUSLE. At national and continental levels, the scarce availability of data obliges soil erosion modellers to estimate this factor based on rainfall data with only low temporal resolution (daily, monthly, annual averages). The purpose of this study is to assess rainfall erosivity in Europe in the form of the RUSLE R-factor, based on the best available datasets. Data have been collected from 1541 precipitation stations in all European Union (EU) Member States and Switzerland, with temporal resolutions of 5 to 60 min. The R-factor values calculated from precipitation data of different temporal resolutions were normalised to R-factor values with temporal resolutions of 30 min using linear regression functions. Precipitation time series ranged from a minimum of 5 years to a maximum of 40 years. The average time series per precipitation station is around 17.1 years, the most datasets including the first decade of the 21st century. Gaussian Process Regression (GPR) has been used to interpolate the R-factor station values to a European rainfall erosivity map at 1 km resolution. The covariates used for the R-factor interpolation were climatic data (total precipitation, seasonal precipitation, precipitation of driest/wettest months, average temperature), elevation and latitude/longitude. The mean R-factor for the EU plus Switzerland is 722 MJ mm ha(-1) h(-1) yr(-1), with the highest values (>1000 MJ mm ha(-1) h(-1) yr(-1)) in the Mediterranean and alpine regions and the lowest (<500 MJ mm ha(-1) h(-1) yr(-1)) in the Nordic countries. The erosivity density (erosivity normalised to annual precipitation amounts) was also the highest in Mediterranean regions which implies high risk for erosive events and floods. PMID:25622150

  19. Clinical application of uterine artery embolization in treating uterine scar pregnancy

    International Nuclear Information System (INIS)

    Objective: To evaluate uterine artery embolization in treating uterine scar pregnancy. Methods: During the period from November 2007 to February 2010, 11 patients with uterine scar pregnancy were encountered in authors' hospital. All the patients had a history of lower uterine segment cesarean section. Four patients had to receive an emergency uterine artery embolization due to acute massive vaginal bleeding. The other 7 patients received intravenous chemotherapy with MTX (0.4 mg/kg/day, every 5 days as a treatment course). Emergency uterine artery embolization had to be carried out in three patients as they developed acute massive vaginal bleeding (blood loss ? 100 ml/hour) during the course of chemotherapy, while subsequent uterine artery embolization was performed in the remaining 4 patients after they had completed two courses of treatment when their blood HCG showed no significant decrease. The clinical results were analyzed. Results: Remarkable decrease in serum HCG was seen in all 11 patients after interventional management. The vaginal bleeding in 7 patients was significantly reduced within half an hour after uterine artery embolization. The uterus together with intact fertility was successfully preserved in all 11 patients. Conclusion: For the treatment of uterine scar pregnancy complicated by massive vaginal bleeding (blood loss ? 500 ml/24 h) and/or abnormal elevation of serum HCG (blood ?-HCG ? 20000 IU/L), ectopic pregnancy with the mass diameter ? 5 cm, uterine artery embolization treatment is very safe and effective. This technique can well preserve female patient's uterus and fertility ability. It is of value to employ this treatment in clinical practice. (authors)

  20. Rainfall Erosivity in Europe

    DEFF Research Database (Denmark)

    Panagos, Panos; Ballabio, Cristiano

    2015-01-01

    Rainfall is one the main drivers of soil erosion. The erosive force of rainfall is expressed as rainfall erosivity. Rainfall erosivity considers the rainfall amount and intensity, and is most commonly expressed as the Rfactor in the USLE model and its revised version, RUSLE. At national and continental levels, the scarce availability of data obliges soil erosion modellers to estimate this factor based on rainfall data with only low temporal resolution (daily, monthly, annual averages). The purpose of this study is to assess rainfall erosivity in Europe in the form of the RUSLE R-factor, based on the best available datasets. Data have been collected from 1541 precipitation stations in all European Union (EU) Member States and Switzerland, with temporal resolutions of 5 to 60 min. The R-factor values calculated from precipitation data of different temporal resolutions were normalised to R-factor values with temporal resolutions of 30 min using linear regression functions. Precipitation time series ranged from a minimum of 5 years to a maximum of 40 years. The average time series per precipitation station is around 17.1 years, the most datasets including the first decade of the 21st century. Gaussian Process Regression (GPR) has been used to interpolate the R-factor station values to a European rainfall erosivity map at 1 km resolution. The covariates used for the R-factor interpolation were climatic data (total precipitation, seasonal precipitation, precipitation of driest/wettest months, average temperature), elevation and latitude/longitude. The mean R-factor for the EU plus Switzerland is 722 MJ mm ha?1 h?1 yr?1, with the highest values (N1000 MJ mm ha?1 h?1 yr?1) in the Mediterranean and alpine regions and the lowest (b500 MJ mm ha?1 h?1 yr?1) in the Nordic countries.

  1. Relationship of uterine artery with ureter.

    Science.gov (United States)

    Ara, Z G; Khalil, M; Rahman, M H; Mannan, S; Sultana, S Z; Rahman, M M; Ahmed, M S; Zaman, K S; Islam, M S

    2008-07-01

    The study was done to see the relationship of right and left uterine artery with corresponding ureter. Their distance from lateral border of uterus and site of crossing in relation to internal os in Bangladeshi female were observed. Sixty post mortem specimens containing uterus, uterine tube, ureter and surrounding structures were collected from cadavers of different age groups and fixed in 10% formol saline solution. Gross and fine dissections were carried out to study the relationship and distance of uterine artery where it crosses the corresponding ureter and the site of crossing in relation to internal os. In the present study our findings were compared with those of the standard text books. In this study, there were no variations regarding relations of right and left uterine artery with corresponding ureter. In all cases of all age groups, ureters were found to cross the uterine artery anteriorly on both sides. Site of crossing of uterine artery of both sides with ureter at the level of internal os was 50% in 2-12 years (Group A) 20.45% in 13-45 years (Group B) and 12.50% in 46-80 years (Group C) age group. Below the level of the os was found in remaining cases except one which crosses above the level of the os in group B. In this study mean distance of uterine artery where it crosses the ureter from lateral border of uterus was more on right side in all age groups, which was 1.67 cm, 2.30 cm and 2.11 cm in age Group A, B & C respectively. PMID:18626447

  2. Human papillomavirus types 16 and 18 in adenocarcinoma of the uterine cervix

    International Nuclear Information System (INIS)

    Many reports have shown a link between human papillomavirus (HPV) and cervical squamous neoplasia. However, the association of HPV with cervical adenocarcinoma has been studied less extensively. The authors evaluated the presence of HPV-DNA in 106 patients with adenocarcinoma of the uterine cervix by in situ hybridization, using 35S-labeled probes for HPV 16 DNA and HPV 18 DNA. The overall prevalence of HPV-DNA was 18% (19 of 106). HPV 16 was present in 2 (2%) cases, HPV 18 was observed in 15 (14%) cases, and both HPV 16 and HPV 18 were found in 2 (2%) cases. There was a correlation between HPV-DNA positivity and tumor stage (P less than 0.01) and tumor size (P less than 0.05), but there was no relationship between HPV-DNA positivity and tumor differentiation, proliferation (S-phase fraction), ploidy, lymph node metastases, or five-year survival rate. These results suggest that HPV 18 DNA is associated with cervical adenocarcinoma but the presence of HPV 18 has no influence on overall survival

  3. Uteroenteric Fistula Resulting From Fibroid Expulsion After Uterine Fibroid Embolization: Case Report and Review of the Literature

    Energy Technology Data Exchange (ETDEWEB)

    Gutierrez, Luis B., E-mail: lbgutier@stanford.edu [Stanford University, School of Medicine (United States); Bansal, Anshuman K., E-mail: abansal@mednet.ucla.edu [University of California at Los Angeles, Department of Radiology (United States); Hovsepian, David M., E-mail: hovsepian@stanford.edu [Stanford University, School of Medicine (United States)

    2012-10-15

    A 44-year-old woman underwent uncomplicated uterine fibroid embolization (UFE) for menstrual and bulk-related symptoms in an enlarged, myomatous uterus. After surgery, she spontaneously sloughed a large mass of fibroids that arrested in the cervical canal during passage. Four days after gynecological extraction, she developed copious vaginal discharge that contained enteric contents. Contrast-enhanced computed tomography (CT) demonstrated a fistula between the small bowel and the uterus. She subsequently underwent hysterectomy, left oophorectomy, and small-bowel resection. Her postoperative recovery was uneventful.

  4. Uteroenteric Fistula Resulting From Fibroid Expulsion After Uterine Fibroid Embolization: Case Report and Review of the Literature

    International Nuclear Information System (INIS)

    A 44-year-old woman underwent uncomplicated uterine fibroid embolization (UFE) for menstrual and bulk-related symptoms in an enlarged, myomatous uterus. After surgery, she spontaneously sloughed a large mass of fibroids that arrested in the cervical canal during passage. Four days after gynecological extraction, she developed copious vaginal discharge that contained enteric contents. Contrast-enhanced computed tomography (CT) demonstrated a fistula between the small bowel and the uterus. She subsequently underwent hysterectomy, left oophorectomy, and small-bowel resection. Her postoperative recovery was uneventful.

  5. Diffusion Weighted Imaging of the Uterus: Regional ADC Variation with Oral Contraceptive Usage and Comparison with Cervical Cancer

    International Nuclear Information System (INIS)

    Background: There is growing interest in diffusion weighted magnetic resonance imaging (MRI) of cervical carcinoma but normal uterine appearances and effects of the oral contraceptive pill (OCP) have not been described. Purpose: To establish apparent diffusion coefficient (ADC) values for normal regions of uterus, determine the effect of the OCP on these values, and compare them with ADCs from cervical cancer. Material and Methods: Twenty-seven premenopausal women (19 taking the OCP) with cervical intraepithelial neoplasia (CIN) were studied with T2W and diffusion weighted MRI (DW-MRI). Regions of interest were drawn on ADC maps by visual matching with T2W images on different zones of the uterus and values compared between women not taking and taking the OCp.A further group of 25 women with clinically obvious tumors of the cervix were also studied with T2W and DW-MRI and ADC values of tumor were compared with ADC values of cervical epithelium and stroma. Results: The ADC values of adjacent zones of the uterus and cervix were significantly different from one another (P<0.001). The junctional zone was seen as a band of restricted diffusion between endometrium and outer myometrium. The ADC value of the junctional zone of the uterus was significantly greater (P<0.001) in patients taking the OCP than those patients not taking the OCp.There was no significant affect of the OCP on the ADC values of other uterine zones. Conclusion: The zonal anatomy of the uterus is well demoe zonal anatomy of the uterus is well demonstrated by DW-MRI with hormonal effects secondary to the OCP affecting junctional zone alone. ADC of cervical tumor is significantly different to cervical epithelium and stroma indicating a role in cervical cancer detection and local staging

  6. Diffusion Weighted Imaging of the Uterus: Regional ADC Variation with Oral Contraceptive Usage and Comparison with Cervical Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Messiou, Christina; Morgan, Veronica A.; Silva, Sonali S. de; Souza, Nandita M. de (Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey (United Kingdom)); Ind, Thomas E. (Dept. of Gynaecology and Obstetrics, St George' s Hospital NHS Trust, London (United Kingdom))

    2009-07-15

    Background: There is growing interest in diffusion weighted magnetic resonance imaging (MRI) of cervical carcinoma but normal uterine appearances and effects of the oral contraceptive pill (OCP) have not been described. Purpose: To establish apparent diffusion coefficient (ADC) values for normal regions of uterus, determine the effect of the OCP on these values, and compare them with ADCs from cervical cancer. Material and Methods: Twenty-seven premenopausal women (19 taking the OCP) with cervical intraepithelial neoplasia (CIN) were studied with T2W and diffusion weighted MRI (DW-MRI). Regions of interest were drawn on ADC maps by visual matching with T2W images on different zones of the uterus and values compared between women not taking and taking the OCp.A further group of 25 women with clinically obvious tumors of the cervix were also studied with T2W and DW-MRI and ADC values of tumor were compared with ADC values of cervical epithelium and stroma. Results: The ADC values of adjacent zones of the uterus and cervix were significantly different from one another (P<0.001). The junctional zone was seen as a band of restricted diffusion between endometrium and outer myometrium. The ADC value of the junctional zone of the uterus was significantly greater (P<0.001) in patients taking the OCP than those patients not taking the OCp.There was no significant affect of the OCP on the ADC values of other uterine zones. Conclusion: The zonal anatomy of the uterus is well demonstrated by DW-MRI with hormonal effects secondary to the OCP affecting junctional zone alone. ADC of cervical tumor is significantly different to cervical epithelium and stroma indicating a role in cervical cancer detection and local staging

  7. SCHWANNOMA INTRAMEDULAR CERVICAL

    Scientific Electronic Library Online (English)

    OSÉ ANTONIO, CHÁVEZ LÓPEZ; DANIEL, RODRÍGUEZ DÍAZ; YADIRA, CISNEROS MEDINA; HUGO, SÁNCHEZ JERÓNIMO; ANTONIO, ZARATE MÉNDEZ; ARMANDO, GONZÁLEZ VÁZQUEZ; MANUEL, HERNÁNDEZ SALAZAR.

    2004-03-01

    Full Text Available Los schwannomas intramedulares son tumores muy raros, sólo se han reportado 39 casos en la literatura desde 1931. Se reporta el caso de una paciente femenino de 40 años de edad, con una historia de mielopatía cervical progresiva. Se realizó el diagnóstico de tumor intrameduIar cervical por RM y se i [...] ntervino quirúrgicamente con laminectomía de C4 a C6 y resección total de la lesión. Su evolución clínica fué hacia la mejoría hasta la integridad neurológica. La RM de control no mostró lesión residual, solo cambios posquirúrgicos. El examen histopatológico reveló un schwannoma. La existencia de un schwannoma intramedular es difícil de explicar por lo que se reporta el presente caso y se discute sobre la patogenía de estas lesiones, así como se hace hincapié sobre la resección quirúrgica total, ya que puede ser curativa. Abstract in english Intramedullary Schwannomas are rare tumors, only 39 cases have been reported in the literature since 1931. The case of a 40-years-old woman with a history of a progressive cervical myelopathy is reported. A diagnosis of a cervical intramedullary tumor was made by magnetic resonance imaginig, C4-C6 l [...] aminectomy and a total resection were performed. The patient had completely recovered from her preoperative deficit. Postoperative MRI revealed only postsurgical changes without tumor. Pathological examination revealed a Schwannoma. The existence of Intraparenchymal Schwannomas is difficult to explain therefore we reported this case and discussed the literature on the pathogenic and insist in surgical resection.

  8. Prevent Cervical Cancer!

    Centers for Disease Control (CDC) Podcasts

    2015-01-08

    Cervical cancer can be prevented. Listen as two friendsâ??one a doctorâ??talk about screening tests and early detection. Learn what test you might need.  Created: 1/8/2015 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 1/8/2015.

  9. The biology of uterine sarcomas: A review and update

    OpenAIRE

    KOBAYASHI, HIROSHI; UEKURI, CHIAKI; AKASAKA, JURIA; ITO, FUMINORI; SHIGEMITSU, AIKO; KOIKE, NATSUKI; SHIGETOMI, HIROSHI

    2013-01-01

    Uterine sarcoma is a rare neoplasm, accounting for only 5% of uterine malignancies. The pathogenesis of uterine sarcoma remains largely unknown, although recent basic science and pre-clinical animal models have provided a better understanding of tumor biology. The aim of this study was to review the clinical features, imaging characteristics, genetic aberrations and therapeutic approaches in uterine sarcoma. This study reviewed the English-language literature on clinical and basic studies on ...

  10. Bmp2 Is Critical for the Murine Uterine Decidual Response? †

    OpenAIRE

    Lee, Kevin Y.; Jeong, Jae-wook; Wang, Jinrong; Ma, Lijiang; Martin, James F.; Tsai, Sophia Y.; Lydon, John P.; Demayo, Francesco J.

    2007-01-01

    The process of implantation, necessary for all viviparous birth, consists of tightly regulated events, including apposition of the blastocyst, attachment to the uterine lumen, and differentiation of the uterine stroma. In rodents and primates the uterine stroma undergoes a process called decidualization. Decidualization, the process by which the uterine endometrial stroma proliferates and differentiates into large epithelioid decidual cells, is critical to the establishment of fetal-maternal ...

  11. Uterine Epithelioid Angiosarcoma on F-18 FDG PET/CT

    OpenAIRE

    Hwang, Jae Pil; Lim, Sang Moo

    2013-01-01

    Uterine epithelioid angiosarcoma can have conventional imaging characteristics similar to those of other uterine tumors, such as leiomyoma, leiomyosarcomas or hemangioendothelioma. Uterine epithelioid angiosarcoma exhibiting increased fluorine-18 fluorodeoxyglucose (F-18 FDG) activity can be misdiagnosed. A 61-year-old woman who was diagnosed with uterine epithelioid angiosarcoma underwent F-18 FDG positron emission tomography/computed tomography (PET/CT) as a part of the pretreatment work up...

  12. Uterine artery embolization for adenomyosis without fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Kim, M.D. E-mail: mdkim@cha.ac.kr; Won, J.W.; Lee, D.Y.; Ahn, C.-S

    2004-06-01

    AIM: To evaluate the potential usefulness of transcatheter uterine artery embolization as a treatment for symptomatic adenomyosis in patients without uterine fibroids. MATERIALS AND METHODS: Uterine artery embolization using polyvinyl alcohol particles sized 250-710 mm was performed in 43 patients (mean; 40.3 years, range; 31-52 years) with dysmenorrhoea, menorrhagia, or bulk-related symptoms (pelvic heaviness, urinary frequency) due to adenomyosis without fibroids. All patients underwent pre-procedural and 3.5 months (range 1-8 months) follow-up magnetic resonance imaging (MRI) with contrast enhancement. Clinical symptoms were also assessed at the time of MRI before and after embolization. RESULTS: Significant improvement of dysmenorrhoea (95.2%) and menorrhagia (95.0%) was reported in most patients. Contrast-enhanced MRI revealed non-enhancing areas suggesting coagulation necrosis of adenomyosis in 31 patients (72.1%), decreased size without necrosis in 11 patients (25.6%), and no change in one patient (2.3%). The mean volume reduction of the uteri after uterine artery embolization was 32.5% (from 321.7{+-}142.9 to 216.7{+-}130.1 cm{sup 3}). CONCLUSION: Transcatheter uterine artery embolization is an effective therapy for the treatment of symptomatic pure adenomyosis, and may be a valuable alternative to hysterectomy.

  13. Uterine artery embolization for adenomyosis without fibroids

    International Nuclear Information System (INIS)

    AIM: To evaluate the potential usefulness of transcatheter uterine artery embolization as a treatment for symptomatic adenomyosis in patients without uterine fibroids. MATERIALS AND METHODS: Uterine artery embolization using polyvinyl alcohol particles sized 250-710 mm was performed in 43 patients (mean; 40.3 years, range; 31-52 years) with dysmenorrhoea, menorrhagia, or bulk-related symptoms (pelvic heaviness, urinary frequency) due to adenomyosis without fibroids. All patients underwent pre-procedural and 3.5 months (range 1-8 months) follow-up magnetic resonance imaging (MRI) with contrast enhancement. Clinical symptoms were also assessed at the time of MRI before and after embolization. RESULTS: Significant improvement of dysmenorrhoea (95.2%) and menorrhagia (95.0%) was reported in most patients. Contrast-enhanced MRI revealed non-enhancing areas suggesting coagulation necrosis of adenomyosis in 31 patients (72.1%), decreased size without necrosis in 11 patients (25.6%), and no change in one patient (2.3%). The mean volume reduction of the uteri after uterine artery embolization was 32.5% (from 321.7±142.9 to 216.7±130.1 cm3). CONCLUSION: Transcatheter uterine artery embolization is an effective therapy for the treatment of symptomatic pure adenomyosis, and may be a valuable alternative to hysterectomy

  14. Uterine biology in pigs and sheep

    Directory of Open Access Journals (Sweden)

    Bazer Fuller W

    2012-07-01

    Full Text Available Abstract There is a dialogue between the developing conceptus (embryo-fetus and associated placental membranes and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling, implantation, regulation of gene expression by uterine epithelial and stromal cells, placentation and exchange of nutrients and gases. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph required for growth and development of the conceptus and receptivity of the uterus to implantation. Pregnancy recognition signaling mechanisms sustain the functional lifespan of the corpora lutea (CL which produce progesterone, the hormone of pregnancy essential for uterine functions that support implantation and placentation required for a successful outcome of pregnancy. It is within the peri-implantation period that most embryonic deaths occur due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. With proper placentation, the fetal fluids and fetal membranes each have unique functions to ensure hematotrophic and histotrophic nutrition in support of growth and development of the fetus. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. This review addresses the complexity of key mechanisms that are characteristic of successful reproduction in sheep and pigs and gaps in knowledge that must be the subject of research in order to enhance fertility and reproductive health of livestock species.

  15. Evaluation of uterine and fibroid blood supplies before and after uterine artery embolization with dynamic enhanced CT scan

    International Nuclear Information System (INIS)

    Objective: To research the blood supply changes of uterine and fibroid before and after UAE for uterine fibroids. Methods: Sixteen patients with symptomatic uterine myoma were treated by Seldinger's bilateral uterine arteries embolization. The same level dynamic enhanced CT scans were undertaken 7 days before and after the procedure with another one 3 months later. The CT values of uterine and fibroid were measured and analyzed. Results: 16 cases finished the same level dynamic CT enhancement scans successfully. The dynamic enhanced curves and the CT values showed no significant difference in uterine but had significant difference in fibroids. The fibroids were in a state of ischemia after the procedure. Conclusions: Selective uterine arterial embolization is a new safety and effective method for treatment of uterine myoma

  16. Uterine vascular lesions: a rare cause of abnormal uterine bleeding, reporting of two cases

    Directory of Open Access Journals (Sweden)

    Sunita Arora

    2014-06-01

    Full Text Available Uterine vascular lesions in the form of arteriovenous malformation or pseudo aneurysm are rare but potential life-threatening source of bleeding. A high index of suspicion and accurate diagnosis of the condition in a timely manner are essential because instrumentation that is often used for other causes of uterine bleeding can lead to massive hemorrhage. We describe two cases of uterine vascular malformation, one presenting as postabortal hemorrhage and other as postpartum hemorrhage. Case one presented as postabortal hemorrhage after induced abortion following dilatation and curettage. Case two presented as delayed postpartum hemorrhage after six weeks following cesarean section. In both cases diagnosis of uterine arteriovenous malformation was made on Doppler ultrasonography which was subsequently confirmed on pelvic angiography. The embolization of affected uterine arteries was performed successfully in both cases. Uterine vascular lesion should be suspected in patient with abnormal vaginal bleeding, especially who has recent medical history of induced abortion or dilatation and curettage or cesarean section and so on. Although angiography remains the gold standard for making diagnosis, Doppler ultrasonography is also a good noninvasive technique for the same. Uterine artery embolization offers a safe and effective treatment. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 749-753

  17. Uterine arterial methotrexate infusion and embolization in the treatment of uterine adenomyosis

    International Nuclear Information System (INIS)

    Objective: To study the efficacy of treating different types of uterine adenomyosis with transcatheter local infusion of methotrexate (MTX) combined with uterine arterial embolization under guidance of digital subtraction angiography (DSA). Methods: 33 cases were primarily screened out according to clinical symptoms and color Doppler and then further diagnosis as diffuse or local adenomyosis were undertaken with super selective uterine arterial angiography. The patients were then treated with uterine arterial local infusion (50 mg MTX)and embolization with PVA microsphere (diameter 450-650 ?m), individually. Finally, the comparison between the preoperative and postoperative menstruation volumes, the degrees of dysmenorrheal, uterine sizes and the levels of sexual hormones of diffuse and local adenomyosis was carried out. Results: The uterine arterial local infusion of MTX combined with embolization showed no chemotherapeutic side effects. In all cases, there were decrease of menstruation amount, alleviated dysmenorrhea, reduction of uterine size, and the efficacy was more evident in diffuse adenomyosis (P<0.05). Conclusions: Micro-invasive interventional technique combined with drug therapy is promising for diffuse and local adenomyosis especially for the former. (authors)

  18. Clinical efficiency investigation of laparoscopic uterine artery occlusion combined with myomectomy for uterine fibroids.

    Science.gov (United States)

    Yin, Xiang-Hua; Gao, Ling-Ling; Gu, Yang; Song, Jing-Zhe; Gao, Jing; Ji, Xiao-Ping

    2014-01-01

    To investigate the effectiveness of laparoscopic uterine artery occlusion combined with myomectomy for uterine fibroids. From August 2008 to August 2009, forty-eight women with uterine fibroids desiring to preserve their uteri underwent laparoscopic myomectomy. Among them, 18 women received laparoscopic uterine artery occlusion before uterine myomectomy while the others received laparoscopic myomectomy only. All of the 48 cases with uterine fibroids underwent laparoscopic myomectomy successfully, and no patient developed Intraoperative or postoperative complications. The average operation time was (105.6±27.6) min, and the average surgical blood loss was (87.52±18.35) ml. Blocking uterine artery before laparoscopic myomectomy is valuable and feasible for the management of women with symptomatic fibroids. Adopting this method can obtain pleasing therapeutic effect. The method can reduce blood loss thus make the surgical field clean and clear, and it can reduce the operating time and recurrence rate. It can also reduce electro-coagulation on the surgical surface and therefore cause less tissue necrosis and lower incidence of complications. PMID:24995096

  19. Selective uterine artery embolization: its application in treating symptomatic uterine leiomyomas

    International Nuclear Information System (INIS)

    Objective: To discuss the feasibility and safety of uterine artery embolization(UAE) for the treatment of symptomatic uterine leiomyomas. Methods: During the period of Jan. 2005-June 2009, UAE was performed in 85 patients with uterine leiomyomas in the authors' hospital. The main symptoms included hypermenorrhea, delayed menstruation and pelvic pressure symptoms. The bilateral uterine arteries were embolized with polyvinyl alcohol particles (diameter 500-710 ?m) and Gelfoam. The technical success rate and the clinical results were observed. The patients were followed up for 6-36 months. Results: The technical success rate of bilateral uterine artery embolization was 100%. No serious complications occurred. During the follow-up period, menses returned to regular cycle in all patients and the hemoglobin concentration rose up to normal level in patients with anemia. The sizes of uterine leiomyomas were decreased by 57.5% after 6 months of the procedure. Conclusion: UAE is an effective and less-invasive treatment for symptomatic uterine leiomyomas with reliable results and fewer complications. This technique can greatly avoid unnecessary uterectomy and, thus, preserve the fertility of the female patients.(authors)

  20. Regulation of HIV receptor expression in cervical epithelial cells by Gram-negative bacterial lipopolysaccharide

    Scientific Electronic Library Online (English)

    K J, Sales; T, Klein; A A, Katz.

    2015-01-01

    Full Text Available BACKGROUND: Sexually transmitted infections (STIs) caused by the Gram-negative bacteria Chlamydia trachomatis and Neisseria gonorrhoeae are associated with an increased risk of HIV acquisition in South African women. HIV infection involves binding of the virus to CD4+ receptors on host cells and sub [...] sequent binding to a chemokine co-receptor that mediates fusion with the host target cell membrane. OBJECTIVE: To investigate the potential impact of STIs on HIV receptor expression in cervical epithelial cells, and the molecular pathways mediating this effect. METHODS: Expression of Toll-like receptor 4 (TLR4), CD4+ and CCR5 was investigated in HPV type 18-positive (HeLa) and HPV-negative (C33A) cervical epithelial cells, uterine adenocarcinoma cells (Ishikawa), cervical squamous cell carcinoma tissue and normal cervical tissue by real-time polymerase chain reaction (RT-PCR) analysis. HIV receptor expression in HeLa cells was investigated in the presence/absence of 10 ?g/mL bacterial lipopolysaccharide (LPS) and chemical inhibitors of epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK1/2) or cyclo-oxygenase-2 (COX-2) by RT-PCR analysis. RESULTS: TLR4, CD4+ and CCR5 expression was elevated in HeLa, C33A and Ishikawa cell lines and carcinoma tissue, compared with normal cervical tissue. Treatment of HeLa cells with LPS increased expression of the primary HIV chemokine co-receptor CCR5 (p

  1. The clinical application of uterine arterial embolization with dextran microspheres in treating uterine leiomyomas

    International Nuclear Information System (INIS)

    Objective: To prospectively investigate the clinical application of bilateral uterine arterial embolization with dextran microspheres in treating uterine leiomyomas. Methods: A total of 60 patients with uterine leiomyomas, encountered in the authors' hospital during the period from Jan. 2003 to Dec. 2010, were enrolled in this study. The patients were randomly divided into study group and control group with 30 cases in each group. Patients in the study group received bilateral uterine artery embolization by using dextran microspheres (Sephadex, g-50, 100-300 ?m) as embolic agents, while patients in control group received bilateral uterine artery embolization by using KMG (500-700 ?m) as embolic agents. Before and after the treatment, all patients were kept under observation for the menstrual flow, the size of the uterine and the leiomyoma and the changes in sex hormone level. The hospitalization costs were recorded. The results were compared between the two groups. Results: The technical success rate of catheterization and embolization procedure was 100% in both groups. After the therapy, the volumes of both the uterine and the leiomyoma were significantly decreased, but no significant difference in the size reduction existed between the two groups (both P.0.05). The clinical symptoms were markedly improved in all patients. The sex hormone level showed no obvious changes. No serious complications occurred. The hospitalization cost of the study group was significantly lower than that of the control group (P<0.05). Conclusion: For the treatment of uterine leiomyomas, uterine artery embolization with dextran microspheres is very effective and safe. Moreover, the hospitalization cost is lower. Therefore, it is of value to use this technique in clinical practice. (authors)

  2. Effect of mifepristone in cervical ripening for induction of labour

    Directory of Open Access Journals (Sweden)

    Rutuja Athawale

    2013-02-01

    Full Text Available Background: Mifepristone is potentially a method of inducing labour in late pregnancy by increasing uterine contractility and by increasing the sensitivity of the uterus to the actions of prostaglandins. Present study was done to portrait the beneficial of mifepristone induction of labour. The objective was to study the effect of mifepristone in induction of labour with the outcome of induction of labour (IOL. Methods: 100 patients (term were included, after their informed consent. Patients were categorized by BISHOP SCORE at the beginning of induction for comparison of BS, mode of delivery, induction delivery interval (IDI. Women undergoing induction with RU486 (200mg PO were grouped in one and those with placebo control group into another. Statistical analysis of categorical variables was done. Results: Rate of successful IOL or vaginal delivery was 76% in study group and only 36% in control group. After induction with mifepristone for cervical ripening in study group 76% patient who had cervical score 8 within 24 hours, whereas in control group 2% female’s cervical score was>8. Among the babies, 44% in the control group required baby unit admission as compared to 36% in the study group. Conclusions: In the present study, the women who were induced with mifepristone 200 mg per orally showed drastic improvement in cervical score within 24-48 hours and decreased the cesarean rate in the study group and amount of dose requirement of augmentation of labour with Misoprostol or Oxytocin, lesser NICU admission and maternal complication. [Int J Reprod Contracept Obstet Gynecol 2013; 2(1.000: 35-38

  3. Direct measurement of the permeability of human cervical tissue.

    Science.gov (United States)

    Fernandez, Michael; Vink, Joy; Yoshida, Kyoko; Wapner, Ronald; Myers, Kristin M

    2013-02-01

    The mechanical integrity of the uterine cervix is critical for a pregnancy to successfully reach full term. It must be strong to retain the fetus throughout gestation and then undergo a remodeling and softening process before labor for delivery of the fetus. It is believed that cervical insufficiency (CI), a condition in pregnancy resulting in preterm birth (PTB), is related to a cervix with compromised mechanical strength which cannot resist deformation caused by external forces generated by the growing fetus. Such PTBs are responsible for infant developmental problems and in severe cases infant mortality. To understand the etiologies of CI, our overall research goal is to investigate the mechanical behavior of the cervix. Permeability is a mechanical property of hydrated collagenous tissues that dictates the time-dependent response of the tissue to mechanical loading. The goal of this study was to design a novel soft tissue permeability testing device and to present direct hydraulic permeability measurements of excised nonpregnant (NP) and pregnant (PG) human cervical tissue from women with different obstetric histories. Results of hydraulic permeability testing indicate repeatability for specimens from single patients, with an order of magnitude separating the NP and PG group means (2.1?±?1.4×10(-14) and 3.2?±?4.8×10(-13)m(4)/N[middle dot]s, respectively), and large variability within the NP and PG sample groups. Differences were found between samples with similar obstetric histories, supporting the view that medical history may not be a good predictor of permeability (and therefore mechanical behavior) and highlighting the need for patient-specific measurements of cervical mechanical properties. The permeability measurements from this study will be used in future work to model the constitutive material behavior of cervical tissue and to develop in vivo diagnostic tools to stage the progression of labor. PMID:23445069

  4. Contrast enhancement versus vasculature of uterine tumors

    Energy Technology Data Exchange (ETDEWEB)

    Kormano, M.; Kiilholma, P.; Groenroos, M.

    1984-05-01

    The relative contrast enhancement of normal myometrium and small or medium size uterine fibroids and clinical stage I endometrial carcinomas were correlated to their microangiographically demonstrable vascularity. In four cases small uterine fibroids showed contrast enhancement equal to normal myometrium, independent of their vascularity in microangiography. In five, endometrial carcinomas contrast enhancement was always below that of the surrounding myometrium in CT. Intratumour vasculature showed great variability in microangiography. No correlation between the topographic variations in the arrangement or density of tumour blood vessels and the degree of contrast enhancement was found. Contrast enhancement of small uterine fibroids was greater than that of small adenocarcinomas. More contrast material accumulates into the extravascular space of the smooth muscle tissue of the fibroid than into the extravascular space of endometrial carcinoma.

  5. Imaging before and after uterine artery embolization

    International Nuclear Information System (INIS)

    Percutaneous catheter-based embolization treatment of symptomatic uterine fibroids has evolved into the most widely used alternative therapeutic approach to surgical treatment worldwide. Uterine artery embolization (UAE) induces infarction of leiomyomas, resulting in ischemic necrosis, hyaline degeneration, and size reduction with resolution of associated symptoms. Published experience suggests that UAE is an effective and reliable option for treating uterine fibroids with high patient satisfaction. Magnetic resonance imaging (MRI) is superior to ultrasonography for determining the site, size and number of fibroids, which is important for establishing the indication for UAE. Other potential advantages of MRI include the option of performing MR angiography (MRA) and obtaining contrast-enhanced images for monitoring the outcome of UAE and assessing possible complications after UAE. (orig.)

  6. Leprotic cervical spondylodiscitis.

    Science.gov (United States)

    Kim, Sang Jin; Lee, Tae Hoon; Shin, Jun Jae; Chae, Gue Tae

    2010-07-01

    Leprosy is a chronic infectious disease caused by the Mycobacterium leprae that leads to leprotic neuropathy involving the peripheral nerve and several characteristic skin lesions. Skeletal involvement can occur in peripheral joints, such as the wrist and the ankle. However, there is no report of an axial leprotic lesion involving the spine or paraspinal soft tissue. The authors report the first case of a leprotic cervical lesion involving the axial skeletal system. A 48-year-old male presented with neck pain and severe pain in the right suprascapular area and left arm. Preoperative MRI of the cervical spine revealed signal changes in the prevertebral soft tissue at the level of the C3, 4, 5 vertebral bodies. There were a lower signal intensity on T1-weighted image and high signal intensity on T2WI of the bone marrow at the level of the C5 and C6 vertebral bodies, and a C5/6 segmental ossification of the posterior longitudinal ligament. There were herniated cervical disc on the left C5/6 with C6 root and the right side of C6/7 with a C7 root compression. He was previously diagnosed with leprosy when he was 14 years old and received treatment intermittently over the course of 7 years. But patient did not disclose his past history. Surgical intervention was conducted using an anterior cervical approach. An incision was made in the anterior longitudinal ligament at C5/6, and a pinkish gray friable gelatinous material was observed on the C5/6 disc and on the anterior lower one-third surface of the C5 vertebral body. Specimens were obtained and subjected to pathological evaluation and microbiological culture. After C5/6 and C6/7 discectomies, nerve root decompression and autologous iliac bone grafting were performed at the C5/6 and C6/7 levels. The C5-6-7 vertebrae were fixed with an Atlantis cervical locking plate and a screw system. The pathological report indicated chronic inflammation with heavy plasma cell infiltration on the specimen. We sent the specimens to the Institute of Hansen's Disease, and polymerase chain reaction for leprosy tested positive. After surgery, his pain disappeared and he was given a prescription for antileprotic drugs. The authors describe the first case of leprotic cervical spondylodiscitis that was operatively treated in a 48-year-old patient with known leprosy history since his 14 years old. PMID:20372941

  7. The use of castor oil on cervical ripening in pregnancies

    Directory of Open Access Journals (Sweden)

    Z. Saadat

    2008-01-01

    Full Text Available AbstractBackground and Purpose: The role of castor oil on cervical ripening is poorly understood and data in examining its efficacy within clinical trial are limited. This study was performed to evaluate the effect of utilizing castor oil on cervical ripening in pregnancies after 40 weeks.Materials and Methods: A randomized clinical trial study was performed on 200 pregnant women after 40 weeks in Shabikhany Hospital, in the City of Kashan, in 2004 to 2006. Women were divided to two groups (100 women in case group and 100 women in control group. Case group took 60 ml castor oil, while the control group omitted treatment. Comparison was then compared between the two groups for demographic characteristics: increase of Bishop Score, means of Bishop Score at entrance to study and 24 hours after entrance to study, onset of labor within 24 hours, method and time of delivery and newborns Apgar score by X2, followed by Fisher’s exact test, and paired-samples T and T-tests.Results: Results showed that there were no significant differences in mother’s age, education, nationality, gravidity, gestational age, parity between two groups. Paired-sample T test showed significant difference between means of Bishop Score at entrance of study and 24 hours after entrance of study in case and control groups(p=0.00. Furthermore, the mean increase of Bishop score in the case group was 4.5±3.63 versus 0.67±1.25 in the control group during the 24 hour period. During 24 hours after entrance to study, uterine contraction occurred in 70% women in case and 12% women in control groups. Statistical test showed significant difference between the two groups and an increase of Bishop Score at the onset of uterine contractions (P<0.001. There were no significant differences in method of delivery and Apgar score in their newborns between the two groups.Conclusion: The results of this study showed that use of castor oil may lead to cervical ripening in pregnant women after 40 weeks, without increase in complication of pregnancy, such as caesarean, and decrease Apgar score.Key words: Castor oil, Pregnancy, Cervical ripeningJ Mazand Univ Med Sci 2008; 18(63: 11-19 (Persian

  8. Papilomavírus humano e neoplasia cervical Human papillomavirus and cervical neoplasia

    Directory of Open Access Journals (Sweden)

    Maria Inês da Rosa

    2009-05-01

    Full Text Available O papilomavírus humano (HPV é um fator etiológico bem estabelecido para o câncer cervical. Esse vírus de DNA infecta primariamente o epitélio e pode induzir lesões benignas ou malignas na pele e na mucosa. Alguns HPVs são considerados de alto risco, responsáveis pela progressão das lesões precursoras até câncer cervical. A infecção genital pelo HPV é comum em mulheres jovens e geralmente é transitória. Uma pequena proporção de mulheres infectadas desenvolve câncer cervical, implicando o envolvimento de fatores ambientais e fatores genéticos na carcinogênese. Essa revisão aborda a estrutura viral, classificação e patologia do HPV, história natural e fatores de risco para neoplasia cervical e perspectivas futuras com a vacina anti-HPV.Human papillomavirus (HPV has been established as an important etiological factor for the development of cervical cancer. This DNA virus primarily infects the epithelium and can induce benign and malignant lesions of the mucous membranes and skin. Some HPVs are considered high risk due to their role in malignant progression of cervical tumors. Genital HPV infections are common and usually transient among young sexually active women. Only a small fraction of infected women develop cervical cancer, implying the involvement of environmental and genetic cofactors in cervical carcinogenesis. Classification, virology, pathology, natural history, epidemiological features of genital HPV infection, and future prospects for cervical cancer prevention with HPV vaccines will be reviewed here.

  9. Papilomavírus humano e neoplasia cervical / Human papillomavirus and cervical neoplasia

    Scientific Electronic Library Online (English)

    Maria Inês da, Rosa; Lídia Rosi, Medeiros; Daniela Dornelles, Rosa; Mary Clarisse, Bozzeti; Fábio Rosa, Silva; Bruno Rosa, Silva.

    2009-05-01

    Full Text Available O papilomavírus humano (HPV) é um fator etiológico bem estabelecido para o câncer cervical. Esse vírus de DNA infecta primariamente o epitélio e pode induzir lesões benignas ou malignas na pele e na mucosa. Alguns HPVs são considerados de alto risco, responsáveis pela progressão das lesões precursor [...] as até câncer cervical. A infecção genital pelo HPV é comum em mulheres jovens e geralmente é transitória. Uma pequena proporção de mulheres infectadas desenvolve câncer cervical, implicando o envolvimento de fatores ambientais e fatores genéticos na carcinogênese. Essa revisão aborda a estrutura viral, classificação e patologia do HPV, história natural e fatores de risco para neoplasia cervical e perspectivas futuras com a vacina anti-HPV. Abstract in english Human papillomavirus (HPV) has been established as an important etiological factor for the development of cervical cancer. This DNA virus primarily infects the epithelium and can induce benign and malignant lesions of the mucous membranes and skin. Some HPVs are considered high risk due to their rol [...] e in malignant progression of cervical tumors. Genital HPV infections are common and usually transient among young sexually active women. Only a small fraction of infected women develop cervical cancer, implying the involvement of environmental and genetic cofactors in cervical carcinogenesis. Classification, virology, pathology, natural history, epidemiological features of genital HPV infection, and future prospects for cervical cancer prevention with HPV vaccines will be reviewed here.

  10. Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer

    Science.gov (United States)

    2014-12-29

    Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Small Cell Carcinoma; Cervical Squamous Cell Carcinoma; Stage IB Cervical Cancer; Stage IIA Cervical Cancer; Stage IIB Cervical Cancer; Stage III Cervical Cancer; Stage IVA Cervical Cancer

  11. Liquid impingement erosion and cavitation erosion for aging management

    International Nuclear Information System (INIS)

    Both cavitation erosion and liquid impingement erosion are phenomena that can cause pipe wall thinning in power plants. The Code for Power Generation Facilities, Rules on Pipe Wall Thinning Management, was published by the JSME (Japan Society of Mechanical Engineers) in 2005. The code says that cavitation erosion shall be prevented either in the design stage or by daily inspection. On the other hand, liquid impingement erosion can occur in any location where a working fluid attacks a pipe wall at high flow velocities. Therefore, it is very important to evaluate the amount of erosion by liquid impingement for pipe steels quantitatively from the viewpoint of aging management. In this study, we carried out cavitation erosion and liquid impingement erosion tests, and clarified the relation between both erosion rates. As a result, we found that the erosion rate by cavitation increases in proportion with the 5.2nd to 6.8th power of the flow velocity and that by liquid impingement with the 6.0th to 7.4th power. Moreover, a good correlation was obtained between erosion rates by cavitation and by liquid impingement. We also discuss the erosion mechanism with SEM photography, and propose an erosion model. (author)

  12. CDC Vital Signs: Cervical Cancer is Preventable

    Science.gov (United States)

    ... Clips Related Pages Vital Signs Issue details: Cervical Cancer Incidence, Mortality, and Screening — United States, 2007–2012, Morbidity and Mortality Weekly Report (MMWR) Vital Signs – Cervical Cancer [PODCAST - 1:15 minutes] Vital Signs – Cervical Cancer [ ...

  13. Tooth Abrasion and Tooth Erosion

    Science.gov (United States)

    Tooth Abrasion and Tooth Erosion What Is It? Symptoms Diagnosis Expected Duration Prevention Treatment When To Call a Professional Prognosis Additional Info What Is It? Abrasion and erosion are two types of damage that ...

  14. Uterine prolapse: from antiquity to today.

    Science.gov (United States)

    Downing, Keith T

    2012-01-01

    Uterine prolapse is a condition that has likely affected women for all of time as it is documented in the oldest medical literature. By looking at the watershed moments in its recorded history we are able to appreciate the evolution of urogynecology and to gain perspective on the challenges faced by today's female pelvic medicine and reconstructive surgeons in their attempts to treat uterine and vaginal vault prolapse."He who cannot render an account to himself of at least three thousand years of time, will always grope in the darkness of inexperience"-Goethe, Translation of Panebaker. PMID:22262975

  15. Arterial embolisation to treat uterine myomata.

    Science.gov (United States)

    Ravina, J H; Herbreteau, D; Ciraru-Vigneron, N; Bouret, J M; Houdart, E; Aymard, A; Merland, J J

    1995-09-01

    Haemorrhage, probably related to hypervascularisation, is the commonest complication of uterine myomata and is difficult to treat. 16 patients, aged 34-48 years, with symptomatic uterine myomata, for which a major surgical procedure was planned after failure of medical treatment, were treated by selective free-flow arterial embolisation of the myomata with Ivalon particles. With a mean follow-up of 20 months (range 11-48) in the responders, symptoms resolved in 11 patients; menstrual cycles returned to normal in ten of these. Three patients had partial improvement. Two failures required surgery. In 14 cases embolisation caused pelvic pain, which required analgesia in all. PMID:7544859

  16. Radiological appearances of degenerative uterine leiomyomas

    International Nuclear Information System (INIS)

    Uterine fibroids, also known as leiomyomas, are the most common uterine neoplasms. Although benign, they can be associated with significant morbidity and are the commonest indication for hysterectomy. They are often discovered incidentally when performing imaging for other reasons. Usually first identified with US, they can be further characterized with MRI. They are usually easily recognizable, but degenerate fibroids can have unusual appearances. Knowledge of the different appearances of fibroids on imaging is important as it enables prompt diagnosis and thereby guides treatment. (authors)

  17. Optical pen-size reflectometer for monitoring of early dental erosion in native and polished enamels.

    Science.gov (United States)

    Rakhmatullina, Ekaterina; Bossen, Anke; Bachofner, Kai K; Meier, Christoph; Lussi, Adrian

    2013-11-01

    Application of the specular reflection intensity was previously reported for the quantification of early dental erosion. Further development of the technique and assembly of the miniaturized pen-size instrument are described. The optical system was adjusted to fit into a handy device which could potentially access different positions in the oral cavity. The assembled instrument could successfully detect early erosion progression in both polished (n=70) and native (n=20) human enamels. Different severities of enamel erosion were induced by varying incubation time of polished enamel in 1% citric acid (pH=3.60, 0.5 to 10 min), while the native incisors were treated in the commercial orange juice (Tropicana Pure Premium®, pH=3.85, 10 to 60 min). The instrument provided a good differentiation between various severities of the erosion in vitro. The size of the measurement spot affected the erosion monitoring in native enamel (human incisors). The erosion measurement in the 0.7-mm (diameter) cervical spots showed systematically lower reflection intensities compared with the analysis of central and incisal small spots. The application of larger spot areas (2.3 mm) for the erosion monitoring revealed no effect (p>0.05) of the spot position on the reflection signal. High variation of the teeth susceptibility toward in vitro erosion was detected in native enamel. PMID:24247749

  18. Bentonite erosion. Final report

    International Nuclear Information System (INIS)

    Low saline water may reach KBS-3 repository depth, e.g. during periods of glaciation. Under such aqueous conditions, the montmorillonite part of the bentonite buffer might transform into a sol and thereby be transported away with flowing water in fractures. The primary aim with this report is to improve the understanding of the basic principles for this possible montmorillonite particle release. The report includes experimental and theoretical work performed at Clay Technology. Natural bentonite and ion-exchanged purified montmorillonite from three different geographical origins, Wyoming (U.S.), Milos (Greece) and Kutch (India) have been studied. Experimental and/or theoretical investigations have been performed with respect to: - Free swelling ability; - Rheological properties; - Rate of bentonite loss into fractures; - Filtering; - Ion exchange; - Sol formation ability; - Ion diffusion; - Mass loss due to erosion. The performed erosion experiments show that erosion does not occur in a mixed calcium/sodium montmorillonite with at least 20% calcium in exchange positions, when the external solution contains above 4 mM charge equivalents. This result is in agreement with the presented conceptual view of sol formation and measured equilibrium properties in mixed calcium/sodium montmorillonite. The findings imply that the buffer will be stable for non-glacial conditions. However, erosion due to sol formation cannot be ruled out for glacial conditions.

  19. Erosion on a line

    Science.gov (United States)

    Willett, Sean D.

    2010-03-01

    An erosion model is proposed to calculate erosion rates for plane-strain models in which the Earth's surface is represented on a line. The fundamentals of river erosion networks are captured by two principles, Hack's Law, which describes the drainage area structure of river network and a stream-power erosion law, which describes the rate of incision of a river. For a simple morphology of parallel transverse rivers with rectangular drainage basins, this allows the earth's surface to be parameterized by two heights: the trunk stream channel height and the interfluvial ridge height. The resulting expressions are solved for the simple cases of constant uplift rate and a constant mean slope as occurs in critical wedge problems. In the latter case, the uplift rate is variable and changes in space so that the trunk channel elevation and the interfluvial ridge elevation average to maintain a constant mean slope. A general, numerical solution is presented for application to any numerical model with arbitrary surface velocity, variable rock erodibility and precipitation. This algorithm is coupled to a plane-strain, plastic-deformation model to demonstrate the utility of the model.

  20. Bentonite erosion. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Birgersson, Martin; Boergesson, Lennart; Hedstroem, Magnus; Karnland, Ola; Nilsson, Ulf (Clay Technology AB, Lund (Sweden))

    2009-12-15

    Low saline water may reach KBS-3 repository depth, e.g. during periods of glaciation. Under such aqueous conditions, the montmorillonite part of the bentonite buffer might transform into a sol and thereby be transported away with flowing water in fractures. The primary aim with this report is to improve the understanding of the basic principles for this possible montmorillonite particle release. The report includes experimental and theoretical work performed at Clay Technology. Natural bentonite and ion-exchanged purified montmorillonite from three different geographical origins, Wyoming (U.S.), Milos (Greece) and Kutch (India) have been studied. Experimental and/or theoretical investigations have been performed with respect to: - Free swelling ability; - Rheological properties; - Rate of bentonite loss into fractures; - Filtering; - Ion exchange; - Sol formation ability; - Ion diffusion; - Mass loss due to erosion. The performed erosion experiments show that erosion does not occur in a mixed calcium/sodium montmorillonite with at least 20% calcium in exchange positions, when the external solution contains above 4 mM charge equivalents. This result is in agreement with the presented conceptual view of sol formation and measured equilibrium properties in mixed calcium/sodium montmorillonite. The findings imply that the buffer will be stable for non-glacial conditions. However, erosion due to sol formation cannot be ruled out for glacial conditions.

  1. Imaging of cervical carcinomas

    International Nuclear Information System (INIS)

    Recently, magnetic resonance imaging (MRI) and transrectal or transvaginal ultrasound (TRUS, TVUS) had an important place in imaging techniques of cervical carcinomas and raise the question of modifying the imaging strategies. For the diagnosis of primitive tumor, those techniques cannot take the place of clinical examination and gross examination. In the assessment of parametrial involvement, TRUS which has better accuracy than clinical examination, and MRI which is considered as the most accurate technique, have an important role to play. In the follow-up and the detection of recurrences, MRI is actually considered as the best imaging technique. The authors, according to recent data in literature and their own experience, present basic concepts of imaging strategies for staging and follow-up of cervical carcinomas

  2. [Measurement and clinical significance of cervical lordosis].

    Science.gov (United States)

    Zhang, Yu-ting; Wang, Xiang; Zhan, Hong-sheng

    2014-12-01

    Measurement of cervical lordosis is the basic method for evaluating cervical function, and important reference for determine treatment decision. However, how to choose appropriate measurement in accordance with different situation, as well as the relationship among these methods is not clear. An increasing number of studies suggested that different measurements could directly affect the judgment of cervical lordosis. Therefore, comparative study of cervical vertebrae plays an important role in clinical treatment for cervical spondylosis under different cervical curvature conditions. PMID:25638900

  3. Study of cliff shoreline erosion

    OpenAIRE

    Gomez-Pina, Gregorio; Muñoz-Perez, Juan J.; Figueres, Miguel; Garrido, Joaquin; Ponce de Leon, Daniel; Perez, Angela; Velasco, Marta; Lizondo, Susana

    2012-01-01

    In this paper the cliff shoreline erosion on the coastline between Punta Montijo and the Chipiona Port (Cadiz, Spain) is studied. The reasons which cause this erosive phenomenon and the future erosive tendency of these cliffs are estimated, obtaining magnitudes of recession and the rate at which it will occur. Analysis of the current situation has been carried out by determining its plan shape, the study of the theoretical erosion profile of the cliffs and the verification of their failure. T...

  4. Soil erosion and agricultural sustainability

    OpenAIRE

    Montgomery, David R.

    2007-01-01

    Data drawn from a global compilation of studies quantitatively confirm the long-articulated contention that erosion rates from conventionally plowed agricultural fields average 1–2 orders of magnitude greater than rates of soil production, erosion under native vegetation, and long-term geological erosion. The general equivalence of the latter indicates that, considered globally, hillslope soil production and erosion evolve to balance geologic and climate forcing, whereas conventional plow-b...

  5. Erosion of steam turbines elements

    International Nuclear Information System (INIS)

    Reasons for erosion wear of moist-steam turbine blades and elements of power facilities are described, examples of frequently encountered damages are given. Theoretical foundations, methods of calculation and designing of erosion-resistant flow-type part of turbines, subjected to local dynamic loadings with liquid particles, are presented. Methods and devices permitting to decrease the erosion of power facility elements are considered. Calculation technique for turbine blade erosion resistance is presented

  6. Future Directions - Cervical Cancer

    Centers for Disease Control (CDC) Podcasts

    2009-10-15

    Dr. Alan Waxman, a professor of obstetrics and gynecology at the University of New Mexico and chair of the American College of Obstetricians and Gynecologists (ACOG) committee for the underserved, talks about possible changes in cervical cancer screening and management.  Created: 10/15/2009 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Cancer Prevention and Control (DCPC).   Date Released: 6/9/2010.

  7. Case Studies - Cervical Cancer

    Centers for Disease Control (CDC) Podcasts

    2010-10-15

    Dr. Alan Waxman, a professor of obstetrics and gynecology at the University of New Mexico and chair of the American College of Obstetricians and Gynecologists (ACOG) committee for the underserved, talks about several case studies for cervical cancer screening and management.  Created: 10/15/2010 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Cancer Prevention and Control (DCPC).   Date Released: 6/9/2010.

  8. Leprotic cervical spondylodiscitis

    OpenAIRE

    Kim, Sang Jin; Lee, Tae Hoon; Shin, Jun Jae; Chae, Gue Tae

    2010-01-01

    Leprosy is a chronic infectious disease caused by the Mycobacterium leprae that leads to leprotic neuropathy involving the peripheral nerve and several characteristic skin lesions. Skeletal involvement can occur in peripheral joints, such as the wrist and the ankle. However, there is no report of an axial leprotic lesion involving the spine or paraspinal soft tissue. The authors report the first case of a leprotic cervical lesion involving the axial skeletal system. A 48-year-old male present...

  9. MRI Assessment of Uterine Artery Patency and Fibroid Infarction Rates 6 Months after Uterine Artery Embolization with Nonspherical Polyvinyl Alcohol

    Energy Technology Data Exchange (ETDEWEB)

    Das, Raj, E-mail: rajdas@nhs.net; Gonsalves, Michael; Vlahos, Ioannis [St George' s Healthcare NHS Trust, Blackshaw, Department of Radiology (United Kingdom); Manyonda, Issac [St George' s Healthcare NHS Trust, Department of Gynaecology (United Kingdom); Belli, Anna-Maria [St George' s Healthcare NHS Trust, Blackshaw, Department of Radiology (United Kingdom)

    2013-10-15

    Purpose: We have observed significant rates of uterine artery patency after uterine artery embolization (UAE) with nonspherical polyvinyl alcohol (nsPVA) on 6 month follow-up MR scanning. The study aim was to quantitatively assess uterine artery patency after UAE with nsPVA and to assess the effect of continued uterine artery patency on outcomes. Methods: A single centre, retrospective study of 50 patients undergoing bilateral UAE for uterine leiomyomata was undertaken. Pelvic MRI was performed before and 6 months after UAE. All embolizations were performed with nsPVA. Outcome measures included uterine artery patency, uterine and dominant fibroid volume, dominant fibroid percentage infarction, presence of ovarian arterial collaterals, and symptom scores assessed by the Uterine Fibroid Symptom and Quality of Life questionnaire (UFS-QOL). Results: Magnetic resonance angiographic evidence of uterine artery recanalization was demonstrated in 90 % of the patients (64 % bilateral, 26 % unilateral) at 6 months. Eighty percent of all dominant fibroids demonstrated >90 % infarction. The mean percentage reduction in dominant fibroid volume was 35 %. No significant difference was identified between nonpatent, unilateral, and bilateral recanalization of the uterine arteries with regard to percentage dominant fibroid infarction or dominant fibroid volume reduction. The presence of bilaterally or unilaterally patent uterine arteries was not associated with inferior clinical outcomes (symptom score or UFS-QOL scores) at 6 months. Conclusion: The high rates of uterine artery patency challenge the current paradigm that nsPVA is a permanent embolic agent and that permanent uterine artery occlusion is necessary to optimally treat uterine fibroids. Despite high rates of uterine artery recanalization in this cohort, satisfactory fibroid infarction rates and UFS-QOL scores were achieved.

  10. MRI Assessment of Uterine Artery Patency and Fibroid Infarction Rates 6 Months after Uterine Artery Embolization with Nonspherical Polyvinyl Alcohol

    International Nuclear Information System (INIS)

    Purpose: We have observed significant rates of uterine artery patency after uterine artery embolization (UAE) with nonspherical polyvinyl alcohol (nsPVA) on 6 month follow-up MR scanning. The study aim was to quantitatively assess uterine artery patency after UAE with nsPVA and to assess the effect of continued uterine artery patency on outcomes. Methods: A single centre, retrospective study of 50 patients undergoing bilateral UAE for uterine leiomyomata was undertaken. Pelvic MRI was performed before and 6 months after UAE. All embolizations were performed with nsPVA. Outcome measures included uterine artery patency, uterine and dominant fibroid volume, dominant fibroid percentage infarction, presence of ovarian arterial collaterals, and symptom scores assessed by the Uterine Fibroid Symptom and Quality of Life questionnaire (UFS-QOL). Results: Magnetic resonance angiographic evidence of uterine artery recanalization was demonstrated in 90 % of the patients (64 % bilateral, 26 % unilateral) at 6 months. Eighty percent of all dominant fibroids demonstrated >90 % infarction. The mean percentage reduction in dominant fibroid volume was 35 %. No significant difference was identified between nonpatent, unilateral, and bilateral recanalization of the uterine arteries with regard to percentage dominant fibroid infarction or dominant fibroid volume reduction. The presence of bilaterally or unilaterally patent uterine arteries was not associated with inferior clinical outcomes (symptom score or UFS-QOL scores) at 6 months. Conclusion: The high rates of uterine artery patency challenge the current paradigm that nsPVA is a permanent embolic agent and that permanent uterine artery occlusion is necessary to optimally treat uterine fibroids. Despite high rates of uterine artery recanalization in this cohort, satisfactory fibroid infarction rates and UFS-QOL scores were achieved

  11. A terminological matter: paragenesis, antigravitative erosion or antigravitational erosion ?

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    Pasini G.

    2009-07-01

    Full Text Available In the speleological literature three terms are utilized to designate the “ascending erosion”: paragenesis (= paragénésis, coined in1968, antigravitative erosion (= erosione antigravitativa, coined in 1966 and antigravitational erosion (wrong English translation ofthe Italian term erosione antigravitativa, utilized later on. The term paragenesis should be abandoned because of the priority of theterm erosione antigravitativa - on the ground of the “law of priority” – and because of its ambiguous etimology. On the other hand,the term antigravitational erosion should be forsaken in favour of the term antigravitative erosion, given the meaning that the termsgravitation and gravity have in Physics. Therefore, to designate the phenomenon of the “ascending erosion” there would be nothingleft but the term antigravitative erosion.The antigravitative erosion process and its recognizability are illustrated.Examples of caves with evident antigravitative erosion phenomena, developed in different karstifiable rocks and in several partsof the world, are given.It is recalled that the antigravitative erosion is a phenomenon well-known since 1942 and widely proven and supported, and that it isrelatively easy – in many cases - to recognize the antigravitative origin of karstic passages.It is stressed that the antigravitative erosion is an important phenomenon, exclusive of the karstic caves and unique in nature.

  12. A Novel Technique of Uterine Manipulation in Laparoscopic Pelvic Oncosurgical Procedures: “The Uterine Hitch Technique”

    OpenAIRE

    Kulkarni, M. A.; R. M. Sathe; Puntambekar, S. S.; Rayate, N. V.; Patil, A.M.; S. P. Puntambekar

    2010-01-01

    Aim. To describe a new technique of uterine manipulation in laparoscopic management of pelvic cancers. Material and Methods. We used a novel uterine hitch technique in 23 patients from May 2008 to October 2008. These patients underwent pelvic oncologic surgery including laparoscopic radical hysterectomy (n = 7), laparoscopic anterior resection (n = 4), laparoscopic abdominoperineal resection (n = 3), laparoscopic posterior exenteration (n = 4), or laparoscopic anterior exenteration (n = 5). T...

  13. Anastomoses of the Ovarian and Uterine Arteries: A Potential Pitfall and Cause of Failure of Uterine Embolization

    International Nuclear Information System (INIS)

    Four women with symptomatic uterine fibroids were treated by uterine artery embolization (UAE). In all cases both uterine arteries were embolized via a single femoral puncture with polyvinyl alcohol using a selective catheter technique. In three cases, the ovarian artery was not visible on the initial angiogram before embolization, but appeared after the second uterine artery had been treated. In one case of clinical failure following UAE, a repeat angiogram demonstrated filling of the fibroids from the ovarian artery. Anastomoses between uterine and ovarian arteries may cause problems for radiologists performing UAE and are a potential cause of treatment failure

  14. Radiation Therapy and Cisplatin With or Without Epoetin Alfa in Treating Patients With Cervical Cancer and Anemia

    Science.gov (United States)

    2014-12-29

    Anemia; Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Squamous Cell Carcinoma; Drug Toxicity; Radiation Toxicity; Stage IIB Cervical Cancer; Stage III Cervical Cancer; Stage IVA Cervical Cancer

  15. Low-dose rate intracavitary therapy for cancer of the uterine cervix

    International Nuclear Information System (INIS)

    We have treated 661 cases of uterine cervical cancer with a fixed method of low-dose rate intracavitary therapy (Cs-137, 25 to 33 Gy/2-3F after external X-irradiation) since 1973 to 1993. Five-year survival rate was 68% in stage I, 81% in IIa, 63% in IIb, 60% in IIIa, 46% in IIIb and 28% in IV, respectively. Because of high numbers for operated cases in stage I and II, five-year cause specific survival rate for stages I and II was 98% and 80%, respectively. The local control rate was 72.5% and the rate of rectosigmoid colon injury was 7% in 371 cases of stage IIIb. (author)

  16. Small Cell Carcinoma of the Uterine Cervix Misdiagnosed as Squamous Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Aymen Lagha

    2012-11-01

    Full Text Available Small cell carcinoma of the uterine cervix is a rare tumor. It presents clinical and biological features of both cervical neoplasm such as local aggressiveness, and small cell cancer such as early spread and metastases. To date, an effective treatment protocol is not well established. Case: On March 2009, a 44-year-old pregnant woman with small cell carcinoma of the cervix misdiagnosed initially as squamous cell carcinoma, was treated with chemoradiation followed by surgery and brachytherapy. Twenty-three months later, she experienced brain metastases. A metastasectomy lead to an accurate diagnosis. Palliative whole brain radiotherapy was conducted. The patient died of evolutive disease on August 2012. Conclusion: The optimal therapeutic approach of small cell carcinoma of the cervix is still to define. Further studies regarding multimodal treatment are necessary to achieve a significant survival benefit.

  17. MR Reproducibility in the Assessment of Uterine Fibroids for Patients Scheduled for Uterine Artery Embolization

    International Nuclear Information System (INIS)

    Magnetic resonance imaging (MRI) is increasingly applied in the evaluation of uterine fibroids. However, little is known about the reproducibility of MRI in the assessment of uterine fibroids. This study evaluates the inter- and intraobserver variation in the assessment of the uterine fibroids and concomitant adenomyosis in women scheduled for uterine artery embolization (UAE). Forty patients (mean age: 44.5 years) with symptomatic uterine fibroids who were scheduled for UAE underwent T1- and T2-weighted MRI. To study inter- and intraobserver agreement 40 MR images were evaluated independently by two observers and reevaluated by both observers 4 months later. Inter- and intraobserver agreement was calculated using Cohen's ? statistic and intraclass correlation coefficient for categorical and continuous variables, respectively. Inter-observer agreement for uterine volumes (? = 0.99, p 1- and T2-weighted signal intensity of the dominant fibroid there was good agreement between the observers (87%; 95% CI, 71.9%-95.6%) and the intraobserver agreement was good for observer A (95%; 95% CI, 83.1%-99.4%) and moderate for observer B (? = 0.47). The interobserver agreement with respect to the presence of adenomyosis was good (? = 0.73, p < 0.0001), while both intraobserver agreements ile both intraobserver agreements were fair to moderate (observer A, ? = 0.55, p = 0.0003; and observer B, ? = 0.66, p < 0.0001). In conclusion, MRI criteria used for the selection of suitable UAE patients show good inter- and intraobserver reproducibility

  18. Limited uterine artery embolization and the protection of uterine-ovarian artery anastomosis

    International Nuclear Information System (INIS)

    Objective: To investigate how to distinguish and to protect the arterial anastomosis between uterine and ovarian arteries (UA-OAa) during the procedure of embolization of uterine artery for hysteromyoma or solenoma. Methods: DSA findings in 1 056 patients with hysteromyoma or solenoma, who underwent uterine artery embolization (UAE), were retrospectively analyzed. A comparison of imaging findings between pre- and post-procedure was made. Results: Of 1 056 cases receiving UAE, 104 ovarian arteries were displayed in 68 during uterine artery angiography bef6re and/or after embolization, including 47 left ovarian arteries and 57 right ovarian arteries, in accordance with Razavi-I type utero-ovarian anastomosis. Uterine fibroid embolization was achieved while left (n=20) and right (n=27) UA-OAa remained unobstructed. No ovarian failure occurred after UAE in 68 cases during a follow-up of 1-2 years. Ultrasound examination showed that there was no statistically significant difference in shrinking ratio of the tumor between UA-OAa obstructed group (n=9) and UA-OAa unobstructed group (n=24). Conclusion: Limited uterine artery emholization is an effective technique for the treatment of hysteromyoma and solenoma as it can preserve UA-OAa. (authors)

  19. A Cohort Study to Address the Natural History of HPV and Cervical Dysplasia in Trivandrum, South India: Methodological Issues and Initial Results.

    Science.gov (United States)

    Varghese, Cherian; Kalavathy, MC; Amma, NS; Nair, MK

    2001-01-01

    Epidemiological studies, especially cohort studies have many limitations in countries like India. The present population based molecular epidemiolohgical cohort study was planned to address the prevalence, risk factors and natural history of uterine cervical HPV infection in women in an area of suburban dwellings in South India. Epidemiological data, blood samples and cervical scrape smears were collected from women after obtaining an informed consent. A compliance rate of 38% for the first round of screening was noted. More than 70% of women demonstrated evidence of inflammation in their smears. PMID:12718656

  20. Uterine fibroids - clinical presentation and complications

    Directory of Open Access Journals (Sweden)

    Spari? Radmila

    2014-01-01

    Full Text Available Fibroids are the most common benign tumors of the genital organs in women of childbearing age. In some women, fibroids can be present for years without any symptoms and then are discovered accidentally during a gynecological examination. In others, they can cause significant morbidity and necessitate the need for multiple surgical procedures. The scope of this clinical review is to provide information about the clinical data as well as the complications of uterine fibroids and their clinical presentation. The most common symptoms that may occur in women with uterine fibroids include: bleeding (menometrorrhagia, metrorrhagia or intermenstrual bleeding, pain, symptoms of compression of adjacent structures, changed appearance of the abdomen and infertility. Complications of uterine fibroids include: venous thromboembolism, torsion of pedunculated fibroids, acute urinary retention and renal insufficiency, vaginal and intraabdominal bleeding, mesenteric vein thrombosis and gangrene of the intestine. Complications of uterine fibroids fibroids are rare and though they may cause significant morbidity, and rarely, mortality, which indicates the need for further research in this area. Accurate diagnosis is an essential prerequisite for the evaluation of therapeutic options, especially recently, when medical and numerous non-invasive treatment options have become available.

  1. Histogenesis of lipomatous component in uterine lipoleiomyomas

    Directory of Open Access Journals (Sweden)

    Filiz BOLAT

    2007-05-01

    Full Text Available Uterine neoplasms composed of an admixture of smooth muscle and adipose tissue are rare and have been designated as lipoleiomyomas. The origin of this tumor is stil controversial and it has not been sufficiently studied. The aim of our study was to investigate the immunohistochemical phenotype of fat cells in uterine lipoleiomyomas so as to clarify their origin. Archived tissue samples of 10 uterine lipoleiomyomas were selected and analyzed immunohistochemically for vimentin, desmin, and HMB-45 expression. The patients ranged from 31 to 63 years of age (mean age 53.5±9.9. Seven tumors which affected the uterine corpus, showed intramural location; while two cases were subserosal, and one was in the cervix. All tumors were constituted by irregular bundles of smooth cells and mature large adipose cells. The amount of adipose component varied from 5 to 95% of the tumor mass. Cytological atypia and necrosis were not seen. Immunohistochemical investigations revealed obvious reactivity to vimentin and desmin in perivascular immature mesencyhmal cells and tumoral smooth muscle cells. Adipose cells in the tumors demonstrated uniform vimentin expression and inconsistent desmin immunoreactivity. All adipose cells were negative for HMB-45 antigen. However, HMB-45 antigen was weakly positive in spindle shaped tumor cells of two cases. In our study, the immunohistochemical findings suggest a complex histogenesis for these tumors, which may arise from perivascular immature mesencyhmal cells or direct transformation of smooth muscle cells into adipocytes by means of progressive intracellular storage of lipids.

  2. Erosion-corrosion and wear

    OpenAIRE

    Birks, N.; Pettit, F.; Rishel, D.

    1993-01-01

    The basic processes of wear, erosion and erosion-corrosion are reviewed. It is shown that oxide debris can accelerate wear when it is present as particulates, or protect and reduce friction when it is present as a glaze. Erosion-corrosion processes can be understood and organized in a series of regimes that represent a sequence of change in the relative intensities of erosive and corrosive processes. Types of mechanism expected to feature in oxide spallation and in the erosion-corrosion of al...

  3. Rainfall erosivity map for Ghana

    International Nuclear Information System (INIS)

    Monthly rainfall data, spanning over a period of more than thirty years, were used to compute rainfall erosivity indices for various stations in Ghana, using the Fournier index, c, defined as p2/P, where p is the rainfall amount in the wettest month and P is the annual rainfall amount. Values of the rainfall erosivity indices ranged from 24.5 mm at Sunyani in the mid-portion of Ghana to 180.9 mm at Axim in the south western coastal portion. The indices were used to construct a rainfall erosivity map for the country. The map revealed that Ghana may be broadly divided into five major erosion risk zones. The middle sector of Ghana is generally in the low erosion risk zone; the northern sector is in the moderate to severe erosion risk zone, while the coastal sector is in the severe to extreme severe erosion risk zone. (author). 11 refs, 1 fig., 1 tab

  4. Advanced papillary serous carcinoma of the uterine cervix: a case with a remarkable response to paclitaxel and carboplatin combination chemotherapy

    Directory of Open Access Journals (Sweden)

    Tomoyuki Shirase

    2012-01-01

    Full Text Available Papillary serous carcinoma of the uterine cervix (PSCC is a very rare tumor, and is a recently described variant of cervical adenocarcinoma. We experienced a case of stage IV PSCC. The main tumor existed in the uterine cervix and invaded one third of the inferior part of the anterior and posterior vaginal walls. Furthermore, it had metastasized from the para-aortic lymph nodes to bilateral neck lymph nodes. Immnoreactivity for CA125 was positive, whereas the staining for p53 and WT-1 were negative in both the original tumor and the metastatic lymph nodes. We administered six courses of paclitaxel and carboplatin combination chemotherapy against this advanced PSCC. The PSCC therefore dramatically decreased in size. The main tumor of the uterine cervix showed a complete response by magnetic resonance imaging (MRI, and more than 95% of the tumor cells in the cervix had microscopically disapperared. This is the first report of PSCC in which combination chemotherapy was used and showed a remarkable response.

  5. Erosion in Rivers

    Science.gov (United States)

    AMPS GK-12 Program,

    Students learn about water erosion through an experimental process in which small-scale buildings are placed along a simulated riverbank to experience a range of flooding conditions. They learn how soil conditions are important to the stability or failure of civil engineering projects and how a river's turns and bends (curvature, sinuosity) make a difference in the likelihood of erosion. They make model buildings either with a 3D printer or with LEGO® pieces and then see how their designs and riverbank placements are impacted by slow (laminar) and fast (turbulent) water flow over the soil. Students make predictions, observations and conclusions about the stability of their model houses, and develop ideas for how to mitigate damage in civil engineering projects.

  6. Prolapsed Giant Posterior Cervical Leiomyoma

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    Ramya.R

    2013-09-01

    Full Text Available Introduction Leiomyoma of uterus is the most common tumor in women in reproductive age. They are asymptomatic in 50% of cases.1 Cervical fibroids accounts for 0.4% of leiomyomas.2 We hereby present a case of prolapsed giant posterior cervical fibroid which required surgical intervention.

  7. Cervical Spondylotic Myelopathy Mimicking ALS

    OpenAIRE

    Pc, Subramaniam; Kumar R.; Biswas A

    2008-01-01

    Cervical spondylotic myelopathy presenting with muscle wasting in upper extremities and insignificantsensory loss has been termed as cervical spondylotic amyotrophy. This condition has to be differentiatedfrom Amyotrophic lateral sclerosis which also has similar presentation. Here we present a case study ofcervical spondylotic myelopathy resembling Amyotrophic lateral sclerosis clinically.

  8. Cervical Spondylotic Myelopathy Mimicking ALS

    Directory of Open Access Journals (Sweden)

    Subramaniam PC

    2008-10-01

    Full Text Available Cervical spondylotic myelopathy presenting with muscle wasting in upper extremities and insignificantsensory loss has been termed as cervical spondylotic amyotrophy. This condition has to be differentiatedfrom Amyotrophic lateral sclerosis which also has similar presentation. Here we present a case study ofcervical spondylotic myelopathy resembling Amyotrophic lateral sclerosis clinically.

  9. MRI of the uterus, uterine cervix, and vagina: diagnostic performance of dynamic contrast-enhanced fast multiplanar gradient-echo imaging in comparison with fast spin-echo T2-weighted pulse imaging

    International Nuclear Information System (INIS)

    The aim of this study was to compare the diagnostic performance of contrast-enhanced fast multiplanar gradient-echo (GRE) and T2-weighted fast spin-echo (FSE) image sets in the assessment of uterus, cervix, and vagina. Fast (up to 20 contiguous sections in 23 s) multiplanar GRE and FSE images of 45 patients referred for imaging of the female pelvis were evaluated retrospectively with regard to overall image quality and the ability to detect normal anatomic structures, as well as lesion conspicuity. Results were compared with histologic findings (n = 29) or clinical follow-up. Furthermore, a quantitative assessment of contrast-to-noise ratios among normal uterine and cervical structures as well as uterine lesions was performed for both sequences. On GRE images, uterine and cervical differentiation was best seen on the image sets acquired 15 and 60 s following contrast enhancement and results were significantly better compared with delayed images (p 2 test, the difference in diagnostic performance between FSE and GRE revealed no significant deen FSE and GRE revealed no significant difference, whereas the combination of both techniques performed better than FSE imaging alone (p < 0.05). The presented data suggest that dynamic contrast-enhanced GRE imaging should be part of an MR examination of the female pelvis. Combined GRE and FSE imaging provide an excellent sensitivity in the assessment of uterine and vaginal pathologies. (orig.) (orig.)

  10. Interest of the technical detection of the sentinel node applied to uterine cancers: about three cases; Interet de la technique de detection du ganglion sentinelle appliquee aux cancers de l'uterus: a propos de trois cas

    Energy Technology Data Exchange (ETDEWEB)

    Ech charraq, I.; Ben Rais, N. [CHU de Rabat-Sale, Service de Medecine Nucleaire, Rabat-Sale, Rabat (Morocco); Ech charra, I.; Albertini, A.F. [Hopital Saint-Antoine, Service de Medecine Nucleaire, 75 - Paris (France)

    2009-12-15

    Introduction The sentinel node technique (S.N.) was proposed in cervical cancers in order to optimise the diagnosis of metastases and the lymphatic micrometastases in the early stages while avoiding useless wide clearings out. The identification of this node is done by injection of a dye and/or a radioactive colloid and its ablation for pathological examination. Patients and methods We report the case of three patients followed for a uterine cancer having benefited from a lymphoscintigraphy before surgery. During the surgical procedure, the detection of the sentinel node was carried out after cervical injection of blue dye and using a gamma detection probe. Results The lymphoscintigraphy was positive for two cases with a positive detection for the three cases during the operation. The pathological study revealed a node metastasis for one case. The technical of the sentinel node applied to uterine cancers appears realizable essentially for uterine cancers of early stage (I). However the risk of false negative can be observed in advanced cancer (III), as it is the case of our patient having a negative lymphoscintigraphy. Conclusion The nuclear medicine is important in the detection of the sentinel node of various cancers, uterine cancer included, thus allowing an appropriate cardiologic management. (authors)

  11. A randomized comparison of vaginal prostaglandin E2 with oxytocin plus amniotomy for induction of labour in women with intermediately ripe cervices.

    OpenAIRE

    BENEDETTO, Chiara

    1998-01-01

    OBJECTIVE: To compare the effects of oxytocin and amniotomy or vaginal prostaglandin E2 (PGE2) for induction of labour. STUDY DESIGN: We conducted a randomized clinical trial. Eligible for the trial were women with normal pregnancy, parity 0-3, with intact membranes, >40 weeks of gestation documented by ultrasound examination before 20 weeks gestation, observed in a network of 13 general and teaching hospitals in Italy. Inclusion criteria were cervical Bishop's score 5-7, less than six uterin...

  12. A study on radiosensitivity and prognostic factors of cervical adenocarcinoma

    International Nuclear Information System (INIS)

    Investigations were made, with the patient having uterine cervical adenocarcinoma of differentiated type, on the histological damage of tumor cells caused by irradiation, on the time course of the diminution of adenocarcinoma cells and on the reason why the prognosis of patients with adenocarcinoma is usually poorer than those with squamous cell carcinoma. The results obtained are as follows: 1. As to the histological picture of good irradiation effect, the damage of the nucleus, desquamation of adenocarcinoma cells from their bases and the decrease in the number of carcinoma nests are important changes. 2. The time course of the decrease of the number of adenocarcinoma cells due to irradiation was markedly slower than that of squamous cell carcinoma. 3. As important factors affecting the prognosis of patients with adenocarcinoma, the method of treatments, clinical stage, the size of cervical tumor and the degree of histological invasion may be implicated. In particular, regardless to the method of treatments good prognosis may not be expected to the case which is at advanced clinical stage, has hypertrophy of the cervix greater than 4.5 cm in diameter or deep ulcer formation or shows histological picture of severe infiltration. (author)

  13. Human Papillomavirus Genotype as a Major Determinant of the Course of Cervical Cancer

    Directory of Open Access Journals (Sweden)

    Niakan M

    2004-01-01

    Full Text Available Introduction: Certain types of human papillomavrus (HPV are associated with cervical intraepithelial neoplasia (CIN and squamous cell carcinoma (SCC. The aim of theobservations reported here was to determine whether the prognosis for invasive cancers of the uterine cervix is related to the type of human papillomavirus asociated with the tumor. Material and Methods: Twenty Patients with invasive cervical cancer were prospectively registered from 2000 to 2001. HPV typing was performed by insitu hybridization(ISH on DNA extracted from frozen, formal in-fixed, paraffin-embedded tumor specimens. The specimens mostly represented classifications SCC Stage 1 and Stage 2 of the International Federation of Gynecology and Obstetrics (Table 1. HPV- DNA was detected by insituhybridization, using three different DNA Probes: types 6/11, 16/18 and 31/33/51. Results: HPV DNA was detected in the nuclei of SCC tumor cells in 13(65% of 20 cases. Of the 13 HPV-DNA positive cases three reacted only with the HPV 31/33/51 probe, two reacted only with the 16/18 probe, three showed strong hybridization for both 31/33/51 and 6/11probes, four showed 6/11 and 16/18 genotypes and one case reacted with 31/33/51,6/11and16/18probes. Conclusion: The prognosis for invasive cancers of the uterine cervix is dependent on the oncogenic potential of the associated HPV type. HPV typing may provide a prognostic indicator for individual patients and is of potential use in defining specific therapies against HPV harboring tumor cells. These findings are consistent with the hypothesis that HPV infection is the primary cause of cervical neoplasia. Furthermore, they support HPV vaccine research to prevent cervical cancer and efforts to develop HPV DNA diagnostic tests.

  14. Fractures of the cervical spine

    Scientific Electronic Library Online (English)

    Raphael Martus, Marcon; Alexandre Fogaca, Cristante; William Jacobsen, Teixeira; Douglas Kenji, Narasaki; Reginaldo Perilo, Oliveira; Tarcisio Eloy Pessoa de, Barros.

    2013-11-01

    Full Text Available OBJECTIVES: The aim of this study was to review the literature on cervical spine fractures. METHODS: The literature on the diagnosis, classification, and treatment of lower and upper cervical fractures and dislocations was reviewed. RESULTS: Fractures of the cervical spine may be present in pol [...] ytraumatized patients and should be suspected in patients complaining of neck pain. These fractures are more common in men approximately 30 years of age and are most often caused by automobile accidents. The cervical spine is divided into the upper cervical spine (occiput-C2) and the lower cervical spine (C3-C7), according to anatomical differences. Fractures in the upper cervical spine include fractures of the occipital condyle and the atlas, atlanto-axial dislocations, fractures of the odontoid process, and hangman's fractures in the C2 segment. These fractures are characterized based on specific classifications. In the lower cervical spine, fractures follow the same pattern as in other segments of the spine; currently, the most widely used classification is the SLIC (Subaxial Injury Classification), which predicts the prognosis of an injury based on morphology, the integrity of the disc-ligamentous complex, and the patient's neurological status. It is important to correctly classify the fracture to ensure appropriate treatment. Nerve or spinal cord injuries, pseudarthrosis or malunion, and postoperative infection are the main complications of cervical spine fractures. CONCLUSIONS: Fractures of the cervical spine are potentially serious and devastating if not properly treated. Achieving the correct diagnosis and classification of a lesion is the first step toward identifying the most appropriate treatment, which can be either surgical or conservative.

  15. Cervical metastatic glioblastoma multiforme

    International Nuclear Information System (INIS)

    Glioblastoma multiforme (GBM) is the most common and most malignant primary brain tumour in adults. In spite of the hostile nature of glioblastoma multiforme (GBM), extracranial spread is not a common event. With improving management choices and survival times, reports of extracranial occurrence of GBM have increased. Most commonly these metastases are to the lungs, lymph nodes, neck, skull, scalp, liver, and bones; may be evident on routine follow-up images of the original lesion. Head and neck metastasis of GBM can be debilitating. We present a case of cervical metastasis of GBM and discuss possible mechanisms of extraneural spread of this tumour. (author)

  16. Cervical facet joint arthrography

    International Nuclear Information System (INIS)

    We describe a technique for cervical facet joint arthrography; a posterior approach is used. The patient is positioned prone, the neck flexed maximally, and the head turned 60-90 degrees opposite to the side of injection. The x-ray tube is angled cephalad in order to obtain a true tangent to the facet joint. The needle is inserted using fluoroscopic control in a direction parallel to the x-ray beam. Before the therapeutic infiltration, the intraarticular position of the needle is confirmed by injecting 0.3 ml of contrast medium

  17. Odontogenic cervical necrotizing fasciitis

    International Nuclear Information System (INIS)

    Two cases of cervical necrotizing fasciitis, secondary to dental infection, are presented. It is a potentially life threatening severe mixed infection with rapidly progressive inflammation and necrosis of the fascia, muscle and fat. Laboratory and CT features are described. CT scan was also useful for progress monitoring during the treatment. Both cases were complicated by mediastinitis with pleural effusions. A successful non-fatal outcome was achieved following multiple surgical interventions, aggressive culture based antimicrobial therapy, multi-specialty approach and intensive supportive care of the patients. (author)

  18. Challenging the in-vivo assessment of biomechanical properties of the uterine cervix: A critical analysis of ultrasound based quasi-static procedures.

    Science.gov (United States)

    Maurer, M M; Badir, S; Pensalfini, M; Bajka, M; Abitabile, P; Zimmermann, R; Mazza, E

    2015-06-25

    Measuring the stiffness of the uterine cervix might be useful in the prediction of preterm delivery, a still unsolved health issue of global dimensions. Recently, a number of clinical studies have addressed this topic, proposing quantitative methods for the assessment of the mechanical properties of the cervix. Quasi-static elastography, maximum compressibility using ultrasound and aspiration tests have been applied for this purpose. The results obtained with the different methods seem to provide contradictory information about the physiologic development of cervical stiffness during pregnancy. Simulations and experiments were performed in order to rationalize the findings obtained with ultrasound based, quasi-static procedures. The experimental and computational results clearly illustrate that standardization of quasi-static elastography leads to repeatable strain values, but for different loading forces. Since force cannot be controlled, this current approach does not allow the distinction between a globally soft and stiff cervix. It is further shown that introducing a reference elastomer into the elastography measurement might overcome the problem of force standardization, but a careful mechanical analysis is required to obtain reliable stiffness values for cervical tissue. In contrast, the maximum compressibility procedure leads to a repeatable, semi-quantitative assessment of cervical consistency, due to the nonlinear nature of the mechanical behavior of cervical tissue. The evolution of cervical stiffness in pregnancy obtained with this procedure is in line with data from aspiration tests. PMID:25791058

  19. Inactivación de genes supresores de tumores en la carcinogénesis del cuello uterino Inactivation of tumor suppressor genes in uterine cervix carginogenesis

    Directory of Open Access Journals (Sweden)

    Rodrigo Chuaqui F

    1999-12-01

    Full Text Available The importance of inactivation of tumor suppressor genes in the development/progression of carcinomas of the uterine cervix is reviewed. It is well known that HPV-related oncogenes are strongly linked to cervical cancer. However, fewer studies have explored the occurrence of inactivation of tumor suppressor genes in this neoplasia. Genetic deletions affecting tumor suppressor genes are the most common mechanism of inactivation of these genes. Studies using conventional molecular techniques such as restriction fragment length polymorphism (RFLP and Southern Blot showed low frequency of deletions in cervical carcinomas. Detection of deletions by using RFLP and Southern Blot presents several disadvantages, the most important being the difficulty in analyzing pure tumor cells. More sensitive approaches include tissue microdissection and PCR analysis of microsatellites. Using these approaches, it has been shown that genetic deletions are, in fact, frequent events in cervical cancers, being detected in up to 95% of the cases. Multiple genetic loci are involved, including chromosomes 3p, 5p, 6p and 11q. Deletions are detected even in precursor lesions (cervical intraepithelial neoplasia, CIN. Some deletions have been correlated with prognostic parameters, such as stage, depth of invasion, and vascular space involvement. It is concluded that cervical carcinogenesis, like in other tumors, is a multistep process, characterized by the accumulation of events including activation of oncogenes, as well as inactivation of tumor suppressor genes.

  20. The Content of Soluble HLA Class I and HLA-DR Molecules in Serum in Patients with Uterine Cervix and Body Pathology

    Directory of Open Access Journals (Sweden)

    ?.?. Mamaeva

    2014-06-01

    Full Text Available The aim of the investigation was to assess the correlation of the content of soluble HLA (sHLAI class I and HLA-DR (sHLA-DR molecules in blood serum of patients with uterine cervix and body pathologies, and their pathology type, tumor grade, the number and localization of myomatous nodes. Materials and Methods. 142 women with uterine cervix and body pathology aged 31–79 years (median — 52 years were under study. Serum level of sHLAI and sHLA-DR molecules was determined by enzyme immunoassay using monoclonal antibodies. Blood samples were drawn from cubital vein. All tests were performed before and after the treatment course. For enzyme immunoassay we used mouse monoclonal antibodies to reveal soluble differentiated molecules. Results. Malignant pathologies of uterine cervix and body and myomas were found to be accompanied by an increased serum level of sHLAI ? sHLA-DR molecules, its degree depending on the type of pathology diagnosed in patients with cervical cancer and hysterocarcinomas, and differentiation degree of adenocarcinoma in hysterocarcinoma patients, the number and localization of myomatous nodes. Initial concentration of soluble HLA class I and HLA-DR molecules in a preoperative period can serve as an additional diagnostic test in patients with uterine tumors for their further selection for surgery.

  1. A Study of Cavitation Erosion

    International Nuclear Information System (INIS)

    The authors performed experimental study for the purpose of the following two items from a viewpoint of cavitation erosion of a cylindrical orifice in view of a problem at the letdown orifice in PWR (Pressurized Water Reactor). 1. To get the critical cavitation parameter of the cylindrical orifice to establish the design criteria for prevention of cavitation erosion, and 2. to ascertain the erosion rate in such an eventuality that the cavitation erosion occurs with the orifice made of stainless steel with precipitation hardening (17-4-Cu hardening type stainless steel), so that we confirm the appropriateness of the design criteria. Regarding the 1. item, we carried out the cavitation tests to get the critical cavitation parameters inside and downstream of the orifice. The test results showed that the cavitation parameter at inception is independent of the length or the diameter of the orifice. Moreover, the design criteria of cavitation erosion of cylindrical orifices have been established. Regarding the 2. item, we tested the erosion rate under high-pressure conditions. The cavitation erosion actually occurred in the cylindrical orifice at the tests that was strongly resemble to the erosion occurred at the plant. It will be seldom to reproduce resemble cavitation erosion in a cylindrical orifice with the hard material used at plants. We could establish the criteria for preventing the cavitation erosion from the test results. (authors)(authors)

  2. Uterine segmentation and volume measurement in uterine fibroid patients' MRI using fuzzy C-mean algorithm and morphological operations

    International Nuclear Information System (INIS)

    Uterine fibroids are common benign tumors of the female pelvis. Uterine artery embolization is an effective treatment of symptomatic uterine fibroids by shrinkage of the size of these tumors. Segmentation of the uterine region is essential for an accurate treatment strategy. Objectives: In this paper, we will introduce a new method for uterine segmentation in T1W and enhanced T1W magnetic resonance images in a group of fibroid patients candidated for UAE in order to make a reliable tool for uterine volumetry. Patients and Methods: Uterine was initially segmented using Fuzzy C-Mean method in T1W-enhanced images and some morphological operations were then applied to refine the initial segmentation. Finally redundant parts were removed by masking the segmented region in T1W-enhanced image over the registered TlW image and using histogram thresholding. This method was evaluated using a dataset with ten patients' images (sagittal, axial and coronal views). Results: We compared manually segmented images with the output of our system and obtained a mean similarity of 80percent, mean sensitivity of 75.32percentand a mean specificity of 89.5percent. The Pearson correlation coefficient between the areas measured by the manual method and the automated method was 0.99. Conclusions: The quantitative results illustrate good performance of this method. By uterine segmentation, fibroids in the uterine may be segmented fibroids in the uterine may be segmented and their properties may be analyzed.

  3. Confiabilidade e validade das declarações de óbitos por câncer de útero no município de Belém, Pará, Brasil / Reliability and validity of uterine cancer death certificates in the municipality of Belém, Pará, Brazil

    Scientific Electronic Library Online (English)

    Jacira, Nunes; Rosalina Jorge, Koifman; Inês Echenique, Mattos; Gina Torres Rego, Monteiro.

    2004-10-01

    Full Text Available Belém, Pára, Brasil, apresenta taxas de mortalidade por câncer de colo uterino bastante elevadas, justificando-se a análise da confiabilidade e validade da causa básica do óbito declarada. Selecionou-se declarações de óbito de residentes de Belém, de 1998-1999, com causa básica de morte neoplasia do [...] colo, corpo e porção não especificada do útero e aquelas que mencionavam essas neoplasias em qualquer linha do atestado, totalizando 188 declarações de óbito. Efetuou-se nova codificação para análise da confiabilidade, aferida pela concordância simples e pela estatística kappa. A causa básica do óbito, após revisão de prontuários médicos e/ou laudos histopatológicos, foi considerada como padrão-ouro para análise da validade de critério, através do valor preditivo positivo. Observou-se concordância simples de 94,0% e kappa de 0,87, sugerindo alta confiabilidade na codificação da causa básica câncer de útero no sistema oficial. Na análise da validade, confirmou-se 120 das 127 originais como colo de útero, três das quatro codificadas como corpo de útero e 18 das 48 classificadas como porção não especificada. Registrou-se aumento de 11,2 % nas neoplasias de colo uterino e redução de 62,5% nos óbitos de porção não especificada do útero. Abstract in english Belém, Pará State, Brazil, presents high mortality rates for uterine cervical cancer, thus justifying an analysis of the reliability and validity of data on this underlying cause of death. Death certificates for Belém residents who died in 1998-1999 from neoplasms of the uterine cervix, uterine body [...] , or unspecified uterine site, or with mention of such a neoplasm on any line in the death certificate, were selected, amounting to 188 death certificates (DCs). All DCs were submitted to new coding, and reliability analysis was performed by simple agreement and Cohen's kappa. The underlying cause of death, established after review of medical records and/or histopathological findings, was considered the gold standard for analysis of criteria validity, based on the positive predictive value. We observed a simple agreement of 94.0% and kappa of 0.87, suggesting high reliability of the official system's coding of uterine cancer as the underlying cause of death. In the validity analysis, 120 of the 127 deaths originally considered as caused by cancer of the uterine cervix and 3 of the 4 coded as cancer of the uterine body were confirmed. An 11.2% increase in uterine cervical tumors and a reduction of 62.5% in unspecified uterine tumors were observed.

  4. Radiotherapy for cervical cancer. Multi-institute retrospective analysis

    International Nuclear Information System (INIS)

    Radiotherapy has long been recognized as a successful treatment modality for all stages of carcinoma of the uterine cervix. Patients present first at gynecologic clinics, and it is gynecologists in most institutions who determine the treatment modality without additional inputs of radiotherapists. Most gynecologists consider that surgical treatment is superior to radiotherapy, and, as a result, the majority of patients with stage 0-IIb become subjected to modified or radical hysterectomy and lymphadenectomy. Radiotherapists have to mostly treat the patients with far advanced cancer. Periodic check-ups for uterine cancer have become a very common practice for women over the age 30 years. As a result, the incidence of patients with early stages of cervical cancer subjected to surgery has increased, and that with advanced diseases significantly decreased in recent 10 years. Patients who have cervical cancer and visit radiotherapy department decreased to about 1/3, compared to 15 years ago. In 1983, the standard treatment method of cervical cancer with Co-60 RALS was proposed by Arai et al in Japan. Most institutes accepted this method with some modifications. JASTRO organized the study group to reconsider the treatment modality proposed by Arai et al and reviewed the outcomes from 9 major institutes in Japan. The treatment results of stages I and IVA were different in each institute in spite of applying the similar treatment modality. There was large difference of tumor lity. There was large difference of tumor sizes in stage IIIB. Arai et al suggested that stage IIIB must be subclassified into 3 groups according to tumor volumes, those were small, medium and large. The study group certified this subclassification was very useful to compare the treatment results of stage IIIB. Furthermore, the study group suggests that the more objective tumor measurement is necessary to compare the treatment results in a multi-institutional study. As for stage IV, some institutes introduced CT and/or MR imaging to evaluate invasion to the rectum or the bladder, and reported good results. The study group found that the clinical staging system was so confused in Japan and suggested that the definition of the clinical staging system must be reconfirmed. (author)

  5. Radiotherapy for cervical cancer. Multi-institute retrospective analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Hisao [Chiba Univ. (Japan). School of Medicine; Yoshida, Hiroshi; Kikuchi, Yuzo [and others

    2000-06-01

    Radiotherapy has long been recognized as a successful treatment modality for all stages of carcinoma of the uterine cervix. Patients present first at gynecologic clinics, and it is gynecologists in most institutions who determine the treatment modality without additional inputs of radiotherapists. Most gynecologists consider that surgical treatment is superior to radiotherapy, and, as a result, the majority of patients with stage 0-IIb become subjected to modified or radical hysterectomy and lymphadenectomy. Radiotherapists have to mostly treat the patients with far advanced cancer. Periodic check-ups for uterine cancer have become a very common practice for women over the age 30 years. As a result, the incidence of patients with early stages of cervical cancer subjected to surgery has increased, and that with advanced diseases significantly decreased in recent 10 years. Patients who have cervical cancer and visit radiotherapy department decreased to about 1/3, compared to 15 years ago. In 1983, the standard treatment method of cervical cancer with Co-60 RALS was proposed by Arai et al in Japan. Most institutes accepted this method with some modifications. JASTRO organized the study group to reconsider the treatment modality proposed by Arai et al and reviewed the outcomes from 9 major institutes in Japan. The treatment results of stages I and IVA were different in each institute in spite of applying the similar treatment modality. There was large difference of tumor sizes in stage IIIB. Arai et al suggested that stage IIIB must be subclassified into 3 groups according to tumor volumes, those were small, medium and large. The study group certified this subclassification was very useful to compare the treatment results of stage IIIB. Furthermore, the study group suggests that the more objective tumor measurement is necessary to compare the treatment results in a multi-institutional study. As for stage IV, some institutes introduced CT and/or MR imaging to evaluate invasion to the rectum or the bladder, and reported good results. The study group found that the clinical staging system was so confused in Japan and suggested that the definition of the clinical staging system must be reconfirmed. (author)

  6. Eolian erosion of the Martian surface. I - Erosion rate similitude

    Science.gov (United States)

    Iversen, J. D.; White, B. R.; Greeley, R.; Pollack, J. B.

    1975-01-01

    A similitude parameter is derived which is based on theoretical considerations of erosion due to sand in saltation. This parameter has been used to correlate wind tunnel experiments of particle flow over model craters. The characteristics of the flow field in the vicinity and downstream of a crater are discussed and it is shown that erosion is initiated in areas lying under a pair of trailing vortices. The erosion rate parameter is used to calculate erosion rates on Mars, reported in Part 2, to be published later.

  7. Isosorbide Mononitrate versus Misoprostol for Cervical Ripening and Induction of Labour at Term.

    Science.gov (United States)

    Guha, K; Fatema, A; Biswas, P K; Haque, E

    2015-04-01

    To assess the efficacy and safety of isosorbide mononitrate (IMN) compared with misoprostol for cervical ripening and labour induction at term. In this comparative study two hundred term pregnant women with indication for induction of labour were randomly divided to receive either 40 mg IMN tablet vaginally (n=100) or 50 ?g misoprostol tablet vaginally (n=100) every 6 hours interval for a maximum of 4 doses. Progress & outcome of cervical ripening, labour induction and adverse effects were assessed. Change in cervical score was higher in misoprostol group than IMN group. Time from start of medication to vaginal delivery in IMN group was significantly longer, 28.66 ± 5.283 hours, than in misoprostol group, 16.12 ± 5.581 hours. Vaginal delivery occurred in 77% in IMN group and 69% in misoprostol group. There were no tachysystole or uterine hyper stimulation in the IMN group while in misoprostol group it was 17% and 11% respectively. Maternal satisfaction was higher in IMN group. Cervical ripening is satisfactory with IMN. Though misoprostol is singly more effective than IMN but IMN with oxytocin results in more vaginal delivery. Fetal and maternal side effects are less in IMN group. PMID:26007264

  8. Psychological effects of diagnosis and treatment of cervical intraepithelial neoplasia : a systematic review

    DEFF Research Database (Denmark)

    Frederiksen, Maria Eiholm; Njor, Sisse

    2014-01-01

    BACKGROUND: Treatment of cervical intraepithelial neoplasia (CIN) is a common minor surgical procedure to prevent uterine cervical cancer. However, news of an abnormality detected at screening for cancer might cause the woman to worry. OBJECTIVES: To investigate the psychological consequences of CIN diagnosis and treatment in a systematic review. DATA SOURCES: We searched PubMed using Medical Subject Headings (MeSH) terms for articles published from January 1990 to February 2013. We also examined the reference lists of retrieved articles. SELECTION CRITERIA: Quantitative studies measuring psychological outcomes in women with a histological diagnosis or treatment of CIN, and in women having an outcome other than CIN at cervical screening. DATA COLLECTION AND ANALYSIS: We abstracted the data using a pre-specified list of study characteristics and measured outcomes. For studies not reporting statistical testing, we estimated the statistical significance of the differences between the compared groups using unpaired t tests. MAIN RESULTS: From 5099 retrieved abstracts, 16 studies were included. Diagnosis and treatment of CIN were associated with worse psychological outcomes than normal cytology test results, but the impact decreased over time. In several but not all studies, CIN appeared to have similar psychological consequences to abnormal smears. No study showed a difference in psychological outcomes between CIN and cervical cancer diagnosis when these were measured some years after diagnosis. CONCLUSIONS: The studies suggested that CIN diagnosis and treatment have a negative psychological impact. However, this conclusion should be viewed in the context of a paucity of rigorously designed studies.

  9. Papillomavirus genomes in human cervical carcinoma: Analysis of their integration and transcriptional activity

    International Nuclear Information System (INIS)

    Eighty-four biopsies derived from cervical tissues were analyzed for the presence of human papillomavirus (HPV) DNA types 6, 16 and 18 using Southern blot hybridization. HPV 6 was found in none of the cervical biopsies, and HPV types 16 and 18 were found in 44% of them. The rate of HPV 16/18 positive samples increased proportionally to the severity of the lesion. In normal tissue there were no positive samples, in mild and moderate dysplasia HPV 16/18 was present in 20% and in severe dysplasia and invasive carcinomas in 37 and 50%, respectively. In biopsies from 13 cases with squamous cell carcinoma of the uterine cervix and CIN III lesions HPV 16 was integrated within the host genome. It was concluded that the virus could be integrated at variable, presumably randomly selected chromosomal loci and with different number of copies. Transcription of HPV 16 and 18 was detected in one cervical cancer in HeLa cells, respectively. These results imply that HPV types 16 and 18 play an etiological role in the carcinogenesis of human cervical epithelial cells. (author)

  10. Molecular testing of human papillomavirus in cervical specimens

    International Nuclear Information System (INIS)

    Objective was to improve the diagnosis of cervical neoplasia by early detection of human papillomavirus (HPV) in uterine cervix, by adding molecular testing of HPV using hybrid capture 2 (HC2) and polymerase chain reaction (PCR) tests to Papanicoalou (Pap) test. One hundred women were enrolled in this study. The mean age (mean+-SD) was 41.97+- 8.76 years and range was 27-65 years. All women had undergone cervical cytological screening with cervical cytology, HPV DNA testing by HC2 and PCR, during the period from January to December 2006, at King Abdul-Aziz University Hospital (KAAUH) and King Fahd research Center, Jeddah, Saudi Arabia. The results were obtained by HC2 for detection of HPV were 5(5%) high-risk HPV, one low-risk HPV (1%) and 94(94%) negative cases. The PCR detected only 4(4%) cases. Using the HC2 test as a reference, sensitivity, specificity, positive predictive, negative predictive values and accuracy of base line Pap were 50, 85, 17.7, 96.4 and 83%; of final Pap smear were 100, 96.8, 66.7, 100, and 97% and for PCR were 66.7, 100, 100, 97.9 and 98%. The Pap test was repeated within a year for patients with abnormal Pap test with positive HPV DNA. Combined screening by cytology and HPV testing using both HC2 and PCR sensitively detects women with existing disease. The absence of HPV DNA provides reassurance that patients are unlikely to develop cancer for several years. We suggest using Pap with HC2 and PCR in screening programs to ensure that women witcreening programs to ensure that women with the double negative result at baseline might safely be screened at longer intervals. (author)

  11. An unusual presentation of recurrent uterine rupture during pregnancy.

    Science.gov (United States)

    Tan, Shu Qi; Thia, Edwin Wee Hong; Tee, Chee Seng John; Yeo, George Seow Heong

    2015-06-01

    We describe a case of recurrent uterine rupture at the site of a previous rupture. Our patient had a history of right interstitial pregnancy with spontaneous uterine fundal rupture at 18 weeks of pregnancy. During her subsequent pregnancy, she was monitored closely by a senior consultant obstetrician. The patient presented at 34 weeks with right hypochondriac pain. She was clinically stable and fetal monitoring showed no signs of fetal distress. Ultrasonography revealed protrusion of the intact amniotic membranes in the abdominal cavity at the uterine fundus. Uterine rupture is a rare but hazardous obstetric complication. High levels of caution should be exercised in patients with a history of prior uterine rupture, as they may present with atypical symptoms. Ultrasonography could provide valuable information in such cases where there is an elevated risk of uterine rupture at the previous rupture site. PMID:26106245

  12. An unusual presentation of recurrent uterine rupture during pregnancy

    Science.gov (United States)

    Tan, Shu Qi; Thia, Edwin Wee Hong; Tee, Chee Seng John; Yeo, George Seow Heong

    2015-01-01

    We describe a case of recurrent uterine rupture at the site of a previous rupture. Our patient had a history of right interstitial pregnancy with spontaneous uterine fundal rupture at 18 weeks of pregnancy. During her subsequent pregnancy, she was monitored closely by a senior consultant obstetrician. The patient presented at 34 weeks with right hypochondriac pain. She was clinically stable and fetal monitoring showed no signs of fetal distress. Ultrasonography revealed protrusion of the intact amniotic membranes in the abdominal cavity at the uterine fundus. Uterine rupture is a rare but hazardous obstetric complication. High levels of caution should be exercised in patients with a history of prior uterine rupture, as they may present with atypical symptoms. Ultrasonography could provide valuable information in such cases where there is an elevated risk of uterine rupture at the previous rupture site.

  13. Fatores de risco não habituais para metástase linfonodal no câncer do colo do útero Unusual risk factors for lymph node metastasis in cancer of the uterine cervix

    Directory of Open Access Journals (Sweden)

    José Humberto Tavares Guerreiro Fregnani

    2007-08-01

    Full Text Available OBJETIVO: Verificar as variáveis associadas às metástases nos linfonodos pélvicos em pacientes com carcinoma do colo do útero nos estádios IB e IIA. MÉTODOS: Estudaram-se 289 pacientes admitidas no Departamento de Ginecologia do Centro de Tratamento e Pesquisa Hospital do Câncer A. C. Camargo com carcinoma invasor do colo do útero (IB e IIA no período de 1980 a 1999 e que foram submetidas à cirurgia radical. A coleta de dados foi realizada a partir dos prontuários e da revisão de cortes histológicos dos colos de útero e dos linfonodos, sendo registrados dados sociodemográficos (idade ao diagnóstico, cor da pele, clínicos (estádio da doença, taxa de hemoglobina pré-operatória e índice de massa corpórea e histopatológicos (tipo histológico, grau histológico, índice mitótico, embolização em capilares linfáticos e/ou sangüíneos, invasão perineural, profundidade de invasão do tumor no estroma cervical, intensidade da reação inflamatória no colo do útero, necrose tumoral, tamanho do tumor, invasão dos ligamentos cervicais laterais e do corpo do útero e status linfonodal. A associação entre a presença de metástase linfonodal e as diversas variáveis foi avaliada pelo teste de Qui-quadrado, pelo teste exato de Fisher e pela regressão logística múltipla. RESULTADOS: Encontrou-se metástase nos linfonodos pélvicos em 65 pacientes (22,5%. Foram identificados os seguintes fatores de risco para metástase linfonodal na análise multivariada: taxa de hemoglobina OBJECTIVE: To investigate the variables associated with pelvic lymph node metastasis in patients with carcinoma of the uterine cervix at stages IB and IIA. METHODS: The study was carried out with 289 patients with invasive carcinoma of the uterine cervix (IB and IIA who underwent radical surgery, admitted to the Gynecology Department of the Treatment and Research Center of the Hospital do Câncer A. C. Camargo, between 1980 and 1999. Data were collected from patient's records and from review of the histological sections from the uterine cervices and the lymph nodes, including sociodemographic data (age at diagnosis, skin color, clinical data (disease stage, preoperative hemoglobin level, body mass index and histopathological data (histological type, histological grade, blood and/or lymphatic capillary embolization, perineural invasion, depth of tumor invasion into cervical stroma, intensity of inflammatory reaction in the uterine cervix, tumor necrosis, tumor size, invasion of the lateral cervical ligaments and uterine body, and lymph node status. Associations between lymph node metastasis and the different variables were evaluated by means of the chi-square test, Fisher's exact test and multiple logistic regression. RESULTS: Pelvic lymph node metastasis was found in 65 patients (22.5%. The following risk factors for lymph node metastasis were identified by multivariate analysis: hemoglobin level <10.0 g% (OR = 3.6; 95% CI: 1.210.7, tumor invasion of the middle third (OR = 3.3; 95% CI: 1.110.7 and deep third of the uterine cervix (OR = 5.4; 95% CI: 1.717.3, absent or slight inflammatory reaction in the uterine cervix (OR = 2.4; 95% CI: 1.15.2 and keratinizing squamous cell carcinoma (OR = 3.3; 95% CI: 1.47.6. CONCLUSIONS: This study identified four risk factors for pelvic lymph node metastasis in patients with carcinoma of the uterine cervix at stages IB and IIA. Of these, three are not usually described in literature as predictive variables for lymph node metastasis (preoperative anemia, absent or slight inflammatory reaction and keratinizing of squamous cell carcinoma.

  14. Current status, questions and challenges of transcatheter uterine artery embolization for the treatment of uterine fibroids

    International Nuclear Information System (INIS)

    Current status, questions and challenges of transcatheter uterine artery embolization (UAE) in the treatment of uterine fibroids were summarized and analysed. It has been proved that UAE presents a good effectiveness in controlling the symptoms and shrinkage of fibroid and uterine volumes during follow-up of 4 to 6.9 years domestically and abroad, but relapse of the fibroid may however occur in 2 years or longer after UAE. Generally speaking, UAE is safe in the treatment of uterine fibroids but has a possibility of serious complications. UAE has no damage on normal uterine tissues but may affect pregnancy and delivery of patients significantly later on the cause of hypoxia and inertia of uterus. UAE may cause amenorrhea in the minority of women with ovarian failure and endometrium atrophy. The current questions are how to improve long-term efficiency to reduce relapse of tumor and to insure the safety of UAE. It is our further task to exploit more new effective and safe embolic agents by using animal and clinical study on the basic knowledge of pathology, pharmacology, biochemistry, endocrinology and molecular biology. (authors)

  15. Uterine peristalsis-induced stresses within the uterine wall may sprout adenomyosis.

    Science.gov (United States)

    Shaked, Sivan; Jaffa, Ariel J; Grisaru, Dan; Elad, David

    2015-06-01

    Adenomyosis is a disease in which ectopic endometrial glands and stromal cells appear in the uterine myometrium. This pathology is common among women of reproductive age, and in addition to chronic pelvic pain and heavy periods it may also cause infertility. The 'tissue injury and repair' mechanism in response to increased intrauterine pressures was proposed as the etiology for migration of fragments of basal endometrium into the myometrial wall. In order to investigate this mechanism, a conceptual two-dimensional model of the uterine wall subjected to intrauterine pressures was implemented using ADINA commercial software. The stress field within the uterine wall was examined for a variety of intrauterine sinusoidal pressure waves with varying frequencies. The results revealed that: (1) as the wavelength of the subjected pressure wave decreased, high concentration of stresses developed near the inner uterine cavity; (2) as the pressure wave frequency increased, high gradients of the stresses were obtained; (3) at menstrual phase, the highest stresses obtained at the endometrial-myometrial interface. Therefore, increased uterine activity results in high stresses which may lead to tissue lesions and detachment of endometrial cells. PMID:25217062

  16. Impaired Ultrasonographic Cervical Assessment After Voiding

    Science.gov (United States)

    Schnettler, William; March, Melissa; Hacker, Michele R.; Modest, Anna Merport; Rodriguez, Diana

    2013-01-01

    OBJECTIVE To estimate whether the timing of bladder emptying affects focal myometrial contraction development and image adequacy. METHODS Women at 14 0/7–32 0/7 weeks of gestation undergoing a transvaginal ultrasound examination from January 1, 2012, to September 1, 2012, were eligible for this blinded randomized controlled trial. Participants were randomly assigned to undergo transvaginal imaging immediately after urination (within 5 minutes) or to defer the imaging by at least 15 minutes. The primary outcome was focal myometrial contraction development as determined by two independent blinded reviews of the images. Secondary outcomes included image adequacy and the diagnosis of placenta previa. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using repeated-measures log binomial regression. RESULTS Two hundred twenty-one women provided 335 randomized encounters for analysis. Women in the deferred scan group were 30% less likely to experience a focal myometrial contraction (28.1% compared with 40.5%, RR 0.70, 95% CI 0.52–0.93) and 41% less likely to have inadequate images (18.6% compared with 31.5%, RR 0.59, 95% CI 0.40–0.86). The two groups were equally likely to be diagnosed with placenta previa (P=.13). However, participants in the deferred scan group were 76% less likely to have images demonstrating a placenta previa and focal myometrial contraction (3.0% compared with 12.5%, RR 0.24, 95% CI 0.09– 0.62) than participants in the immediate scan group. Eight women would need to defer imaging for 15 minutes from bladder voiding to prevent one focal myometrial contraction of the lower uterine segment or inadequate imaging. CONCLUSIONS A brief interval (at least 15 minutes) between voiding and transvaginal cervical evaluation is associated with decreased risk for focal myometrial contractions and improved imaging. PMID:23635680

  17. The effect of performing corrections on reported uterine cancer mortality data in the city of São Paulo

    Scientific Electronic Library Online (English)

    J.L.F., Antunes; V., Wünsch-Filho.

    2006-08-01

    Full Text Available Reports of uterine cancer deaths that do not specify the subsite of the tumor threaten the quality of the epidemiologic appraisal of corpus and cervix uteri cancer mortality. The present study assessed the impact of correcting the estimated corpus and cervix uteri cancer mortality in the city of São [...] Paulo, Brazil. The epidemiologic assessment of death rates comprised the estimation of magnitudes, trends (1980-2003), and area-level distribution based on three strategies: i) using uncorrected death certificate information; ii) correcting estimates of corpus and cervix uteri mortality by fully reallocating unspecified deaths to either one of these categories, and iii) partially correcting specified estimates by maintaining as unspecified a fraction of deaths certified as due to cancer of "uterus not otherwise specified". The proportion of uterine cancer deaths without subsite specification decreased from 42.9% in 1984 to 20.8% in 2003. Partial and full corrections resulted in considerable increases of cervix (31.3 and 48.8%, respectively) and corpus uteri (34.4 and 55.2%) cancer mortality. Partial correction did not change trends for subsite-specific uterine cancer mortality, whereas full correction did, thus representing an early indication of decrease for cervical neoplasms and stability for tumors of the corpus uteri in this population. Ecologic correlations between mortality and socioeconomic indices were unchanged for both strategies of correcting estimates. Reallocating unspecified uterine cancer mortality in contexts with a high proportion of these deaths has a considerable impact on the epidemiologic profile of mortality and provides more reliable estimates of cervix and corpus uteri cancer death rates and trends.

  18. The effect of performing corrections on reported uterine cancer mortality data in the city of São Paulo

    Directory of Open Access Journals (Sweden)

    J.L.F. Antunes

    2006-08-01

    Full Text Available Reports of uterine cancer deaths that do not specify the subsite of the tumor threaten the quality of the epidemiologic appraisal of corpus and cervix uteri cancer mortality. The present study assessed the impact of correcting the estimated corpus and cervix uteri cancer mortality in the city of São Paulo, Brazil. The epidemiologic assessment of death rates comprised the estimation of magnitudes, trends (1980-2003, and area-level distribution based on three strategies: i using uncorrected death certificate information; ii correcting estimates of corpus and cervix uteri mortality by fully reallocating unspecified deaths to either one of these categories, and iii partially correcting specified estimates by maintaining as unspecified a fraction of deaths certified as due to cancer of "uterus not otherwise specified". The proportion of uterine cancer deaths without subsite specification decreased from 42.9% in 1984 to 20.8% in 2003. Partial and full corrections resulted in considerable increases of cervix (31.3 and 48.8%, respectively and corpus uteri (34.4 and 55.2% cancer mortality. Partial correction did not change trends for subsite-specific uterine cancer mortality, whereas full correction did, thus representing an early indication of decrease for cervical neoplasms and stability for tumors of the corpus uteri in this population. Ecologic correlations between mortality and socioeconomic indices were unchanged for both strategies of correcting estimates. Reallocating unspecified uterine cancer mortality in contexts with a high proportion of these deaths has a considerable impact on the epidemiologic profile of mortality and provides more reliable estimates of cervix and corpus uteri cancer death rates and trends.

  19. Surgical Management of Uterine Fibroids at Aminu Kano Teaching Hospital

    OpenAIRE

    Abiodun Omole-Ohonsi; Francis Belga

    2012-01-01

    Objective. To determine the influence of age and parity on the surgical management of uterine fibroids, clinical presentation, presence of pelvic adhesions, cadre of surgeons, and postoperative complications at the Aminu Kano Teaching Hospital, Kano, Nigeria. Methods. A retrospective analysis of 105 cases of uterine fibroids that were managed between 1st January 2003 and 31st December 2007. Results. The period prevalence of uterine fibroids was 24.7% of all major gynecological operations. The...

  20. The Impact of Uterine Leiomyomas on Reproductive Outcomes

    OpenAIRE

    Cook, Heather; Ezzati, Mohammad; Segars, James H.; Mccarthy, Desiree

    2010-01-01

    Uterine leiomyomas (fibroids, myomas) are a common benign disease of the uterus with a prevalence of 8–18%. Prevalence rates vary with race, and fibroids are most common in African American women. Uterine leiomyomas can also be present during pregnancy, which may occur more frequently than previously suspected, with prevalence rates reported of up to 10%. Recent evidence has emerged to clarify the relationship of uterine fibroids on fertility and obstetrical outcomes. In t...

  1. Successful Pregnancy after Treatment with Ulipristal Acetate for Uterine Fibroids

    OpenAIRE

    Javier Monleón; Alicia Martínez-Varea; Daniela Galliano; Antonio Pellicer

    2014-01-01

    This case report presents a clinical pregnancy after ulipristal acetate (UA) to decrease uterine fibroid size. A 37-year-old patient, gravida 1, abortus 1, with uterine fibroids was treated with 5?mg of UA daily for 13 weeks starting eight months after a multiple laparotomic myomectomy. Fibroid shrinkage and restoration of the morphology of endometrial cavity were evaluated in order to allow a subsequent pregnancy. A decrease of the uterine fibroids and a normal morphology of the endometria...

  2. A rare case of uterine leiomyosarcoma: a case report

    OpenAIRE

    Chinamotu Rao N; Sunkavalli Chinna; Rao Meghana; Vellanki Venkata; Kaja Shailaja

    2010-01-01

    Abstract Introduction Malignant change in a leiomyoma or uterine fibroid is termed leiomyosarcoma. It arises from smooth muscle of the uterus and is a rare tumor that accounts for 2% to 5% of all uterine malignancies. Very few cases are reported in the literature. Our patient did not have any history of genital bleeding, which is the usual presentation in uterine sarcoma. We report an original case report of an unusual presentation of this rare tumor arising from the uterus. Case presentation...

  3. Doppler Assessment of Uterine Blood Flow in Recurrent Pregnancy Loss

    OpenAIRE

    Maryam Barzin; Sepideh Peyvandi; Niaz Nabizadeh Nabizadeh

    2011-01-01

    Recurrent spontaneous abortion affects 2%-5% of"ncouples. Uterine perfusion is considered as one of the"nfactors that influences the success of implantation."nDuring the normal menstrual cycle, the impedance"nto uterine artery blood flow diminishes progressively"nduring the luteal phase, reaching the lowest values"nin the period coinciding with the implantation time."nImpedance of uterine arteries is a good indicator of"nthe possibility of a subsequent ...

  4. Saline infusion sonohysterography versus hysteroscopy for uterine cavity evaluation

    OpenAIRE

    Khan Faryal; Jamaat Sadia; Al-Jaroudi Dania

    2011-01-01

    Background and Objectives: The most frequent procedures performed on women with abnormal uterine bleeding are 2D and 3D ultrasound. The most common accepted approach for the management of abnormal uterine bleeding is 2D TV scan followed by therapeutic hysteroscopy. The purpose of this prospective study was to assess whether 3D saline infusion sonohysterography (3D SIS) could replace diagnostic hysteroscopy (DH) for the diagnosis of endometrial pathology, in patients with abnormal uterine blee...

  5. Severe uterine hemorrhage as first manifestation of acute leukemia

    OpenAIRE

    Bodur, Serkan; Ayaz, Yurdakadim; Topallar, Faruk; Erdem, Galip; Gu?n, I?smet

    2013-01-01

    Abstract. Abnormal uterine bleeding is one of the most common presentations in gynecology practice with too many causes. Acute promyelocytic leukemia is one of the serious causes of uterine hemorrhage. Frequency and severity of hemorrage seen in acute promyelocytic leukemia is often associated with disseminated intravascular coagulation which can be life-threatening. A 37-year-old women was admitted to the emergency room with acute severe uterine bleeding, increasing weakness and weight loss...

  6. Hydraulic erosion of cohesive riverbanks

    Science.gov (United States)

    Julian, Jason P.; Torres, Raymond

    2006-06-01

    This study identifies and assesses the controls on hydraulic erosion of cohesive riverbanks on a 600-m reach of an urban ephemeral stream with active bank erosion. We examined hydraulic bank erosion by separating estimated bank shear stress into four properties: magnitude, duration, event peak, and variability. The values of these independent variables were used as a bank erosion context at three transects. Stepwise regression showed that the event peak (maximum peak) of excess shear stress best predicts cohesive bank erosion at the two transects with moderate critical shear stresses (1.93-4.08 N/m 2), while the variability (all peaks) of excess shear stress best predicts erosion at the transect with low critical shear stress (0.95 N/m 2). These results suggest that the amount of hydraulic erosion of cohesive riverbanks is dictated by flow peak intensities. Finally, the results of this study were combined with results from previous bank erosion studies to produce a conceptual model for estimating bank erosion rates based on their silt-clay content.

  7. Late pulmonary metastasis in uterine PEComa

    OpenAIRE

    Dimmler, A.; Seitz, G.; Hohenberger, W.; Kirchner, T.; Faller, G.

    2003-01-01

    Perivascular epithelioid cell tumours (PEComas) other than angiomyolipoma, clear cell “sugar” tumour of the lung, and lymphangioleiomyomatosis are very rare mesenchymal tumours. The uterus seems to be the most prevalent site of involvement, but only 13 cases of uterine PEComa have been described. Three of these cases exhibited local aggressive behaviour and only one showed metastasis. Because of the extremely small number of cases, PEComas are considered tumours of uncertain malignant pot...

  8. Necrotising granulomas of the uterine corpus.

    OpenAIRE

    Akosa, A. B.; Boret, F.

    1993-01-01

    Necrotising granulomatous inflammation of the uterine corpus associated with transcervical laser ablation of the endometrium occurred in four patients. The abnormalities seen, including extensive necrosis and hyalinisation with foreign body giant cells containing black foreign material, and eosinophilic homogenisation around blood vessels, were due to the effects of tissue fulguration. The presence of black foreign material in loosely organised histiocytes should alert the pathologist even in...

  9. Thermal ablative treatment of uterine fibroids.

    Science.gov (United States)

    Quinn, Stephen Derek; Gedroyc, Wladyslaw M

    2015-05-01

    In addition to surgical methods of treating uterine fibroids, numerous non-invasive treatments have been developed. Many of these involve the use of hyperthermia, the heating of tissue by a variety of methods. These include the use of lasers, radiofrequency, microwave energy and high intensity focused ultrasound, guided by both ultrasound and magnetic resonance imaging. In this review we examine the technology behind these treatment modalities and review the current evidence for their use. PMID:25815582

  10. Angioedema cervical Cervical angioedema. Report of one case

    Directory of Open Access Journals (Sweden)

    CATALINA VALENZUELA V

    2008-10-01

    Full Text Available Se presenta el caso de una mujer en la edad media de la vida, hipertensa en tratamiento, con el antecedente de cirugía bariátrica, que desarrolla cuadro de masa cervical asintomática en la que, luego de descartar otras patologías por imágenes y evolución, se diagnosticó Angioedema cervical, el que tuvo regresión total, prácticamente espontánea, en los días siguientes.We report a 45 years oíd woman with a history of high blood pressure and bariatric surgery that consulted for painless sweiling of the cervical región and upper chest. A CAT sean informed an extensive edema involving the lower neck and the superior anterior mediastinum and lytic lesions in the cervical spine. An angioedema was diagnosed, and edema disappeared in five days. After one month of follow up, the patient is in good conditions.

  11. Cervical lipomyelomeningocele: case Illustration / Lipomielomeningocele cervical: Caso clínico

    Scientific Electronic Library Online (English)

    D., Gürkanlar; M., Gonul.

    2007-12-01

    Full Text Available Cervical lipomyelomeningocele is a rare congenital spinal pathology. Lipomyelomeningocele is the commonest cause of congenital tethering, which causes neurological deterioration due to the conus medullaris and root ischemia. Early intervention is recommended even in cases with normal neurological ex [...] aminations in order to prevent deterioration but our patient with cervical lipomyelomeningocele had a normal neurological examination despite his age (22 year-old) and had no urodynamic dysfunction. Abstract in english El lipomielomeningocele cervical es una patología raquídea congénita rara. El lipomielomeningocele es la causa más frecuente de anclaje medular, que da lugar a deterioro neurológico, debido a isquemia del cono medular y de las raíces. Se recomienda la intervención precoz, incluso en casos con examen [...] neurológico normal, con el fin de prevenir un deterioro, pero nuestro paciente con lipomielomeningocele cervical tenía un examen neurológico normal, a pesar de su edad (22 años) y no tenía ninguna disfunción urinaria.

  12. Biologia molecular do câncer cervical Molecular biology of cervical cancer

    Directory of Open Access Journals (Sweden)

    Waldemar Augusto Rivoire

    2006-01-01

    Full Text Available A carcinogênese é um processo de múltiplas etapas. Alterações no equilíbrio citogenético ocorrem na transformação do epitélio normal a câncer cervical. Numerosos estudos apoiam a hipótese de que a infecção por HPV está associada com o desenvolvimento de alterações malignas e pré-malignas do trato genital inferior. Neste trabalho são apresentadas as bases para a compreensão da oncogênese cervical. O ciclo celular é controlado por proto-oncogenes e genes supressores. Quando ocorrem mutações, proto-oncogenes tornam-se oncogenes, que são carcinogênicos e causam multiplicação celular excessiva. A perda da ação de genes supressores funcionais pode levar a célula ao crescimento inadequado. O ciclo celular também pode ser alterado pela ação de vírus, entre eles o HPV (Human Papiloma Virus, de especial interesse na oncogênese cervical. Os tipos de HPV 16 e 18 são os de maior interesse, freqüentemente associados a câncer cervical e anal. O conhecimento das bases moleculares que estão envolvidas na oncogênese cervical tem sido possível devido a utilização de técnicas avançadas de biologia molecular. A associação destas técnicas aos métodos diagnósticos clássicos, poderão levar a uma melhor avaliação das neoplasias cervicais e auxiliar no desenvolvimento de novas terapias, talvez menos invasivas e mais efetivas.Carcinogenesis involves several steps. Disorders of the cytogenetic balance occur during the evolution from normal epithelium to cervical cancer. Several studies support the hypothesis that the Human Papiloma Virus (HPV infection is associated to development of premalignant and malignant lesions of cervical cancer. In this review we show the basis to understand cervical oncogenesis. The cell cycle is controlled by protooncogenes and supressive genes. This orchestrated cell cycle can be affected by virus such as HPV. Of special interest in the cervical carcinogenesis are the HPV subtypes 16 and 18. How HPV immortalizes cervical cells is not fully understood. Advances have been made in the application of molecular biology techniques in the understanding of this mechanism. Once established, these techniques will lead to a better assessment of cervical neoplasias and help the development of new therapies, hopefully less invasive and more effective.

  13. Evaluation on the safety of transcatheter uterine artery embolization for uterine myoma

    International Nuclear Information System (INIS)

    Objective: To observe complications of transcatheter uterine artery embolization (TUAE) for uterine fibroids and to evaluate its long-term safety. Methods: One hundred and ninety-eight women with uterine fibroids were treated by TUAE. The bilateral TUAE were performed using lipiodol-pingyangmycineemulsion (LPE) and gelatin sponge particles in 186 women. Among them, 138 patients were followed up for 1 to 3 year and complications were observed. Results: Complications included ecchymosis and ulceration on buttock (n=1); ulcer of labia minora (n=1); urinary retention (n=12); urinary tract infection (n=1); expelling of necrotic fibroids via vagina (n=5); secondary infection of chocolate cyst of ovary (n=1); increasing in endometrial thickness and calcification (n=1) and amenorrhea (n=2). Conclusion: TUAE is a treatment with long-term safety, while severe complications or sequelae may occur to a few patients, so strict indication should be insisted in patient selection. (authors)

  14. Inflammatory Bowel Disease and Cervical Neoplasia : A Population-Based Nationwide Cohort Study

    DEFF Research Database (Denmark)

    Rungoe, Christine; Simonsen, Jacob

    2015-01-01

    BACKGROUND & AIMS: We examined the risk of cervical neoplasia (dysplasia or cancer) in women with ulcerative colitis (UC) or Crohn's disease (CD). We also calculated the reverse, the risk for diagnosis with cervical neoplasia before development of inflammatory bowel disease (IBD). METHODS: We established a national cohort of women diagnosed with UC (n = 18,691) or CD (n = 8717) between 1979 and 2011 and a control cohort of individually matched women from the general population (controls, n = 1,508,334). Incidence rate ratios (IRRs) of screening activity and diagnosis of cervical neoplasia in women with IBD were assessed by Cox proportional hazards regression analysis. Odds ratios (ORs) of cervical neoplasia before diagnosis of IBD were calculated by using conditional logistic regression. RESULTS: Women with CD underwent cervical cancer screening as often as women in the general population (IRR, 0.99; 95% confidence interval [CI], 0.96-1.02), whereas screening frequency was slightly increased in women with UC (IRR, 1.06; 95% CI, 1.04-1.08). A total of 561 patients with UC were diagnosed with dysplasia during a median follow-up time of 7.8 years, and 28 patients with UC developed cervical cancer, compared with 1918 controls. A total of 407 patients with CD were diagnosed with dysplasia during a median follow-up time of 8.3 years, and 26 patients with CD developed cervical cancer, compared with 940 controls. Patients with UC had increased risk of low-grade (IRR, 1.15; 95% CI, 1.00-1.32) and high-grade (IRR, 1.12; 95% CI, 1.01-1.25) squamous intraepithelial lesions (SILs), whereas patients with CD had increased risks of low-grade SIL (IRR, 1.26; 95% CI, 1.07-1.48), high-grade SIL (IRR, 1.28; 95% CI, 1.13-1.45), and cervical cancer compared with controls (IRR, 1.53; 95% CI, 1.04-2.27). ORs for cervical cancer were also increased 1-9 years before diagnosis of UC, compared with women without UC (OR, 2.78; 95% CI, 2.12-3.64) or CD (OR, 1.85; 95% CI, 1.08-3.15). CONCLUSIONS: In a population-based nationwide cohort study, we found a 2-way association between IBD, notably CD, and neoplastic lesions of the uterine cervix. This observation is not explained by differences in screening activity.

  15. Increased angiogenesis in the uterine cervix associated with human papillomavirus infection.

    Science.gov (United States)

    Nair, P; Gangadevi, T; Jayaprakash, P G; Nair, M B; Nair, M K; Pillai, M R

    1999-01-01

    We studied the relationship between angiogenesis (using the CD34 antibody), the presence of human papilloma virus (HPV) infection, HPV E6 protein expression and the accumulation of p53 protein at various phases of tumour progression in the uterine cervix. Expression of CD34, p53 and HPV E6 protein was evaluated by immunocytochemistry. Presence of the mutant p53 was detected using a mutant specific ELISA, and the type of HPV was determined by the Polymerase Chain Reaction. A total of 230 cervical tissue samples were analyzed and included 40 cases of apparently normal cervical epithelium, 37 low grade squamous intraepithelial lesions (SILs), 43 high grade SILs, 36 well-differentiated squamous cell carcinomas (DSCC), 31 moderately differentiated (MDSCC) and 43 poorly differentiated carcinomas (PDSCC). There was an excellent correlation between the extent of angiogenesis and histological abnormality (r = 0.912, p = 0.000004). The least extent of angiogenesis was seen in normal cervical tissue and low grade SILs where the mean (low power) intra lesional vascular density (ILVD) was 12 +/- 1.13 and 25.66 +/- 5.20, respectively. In high grade squamous intraepithelial lesions (SILs), the mean ILVD value was 80.84 +/- 25.57. In well-differentiated squamous cell carcinomas (WDSCC's) the mean value was 144.22 +/- 28.67 while in moderately differentiated squamous cell carcinomas (MDSCC's) the mean value was 166.29 +/- 34.95 and in poorly differentiated tumours (PDSCC's) 192.42 +/- 27.98. The extent of angiogenesis also correlated to presence of HPV (r = 0.505, p = 0.00001). Increased CD34 expression was associated with the presence of HPV types 16 and 18. A similar correlation was also evident in HPV, 16/18 infected cases expressing the E6 protein (r = 0.612, p = 0.000001). CD34 expression also correlated well with p53 accumulation (r = 0.859, p = 0.000002). Presence of HPV infection significantly correlated with the extent of histological abnormality (r = 0.467, p = 0.00001). Expression of E6 also showed this significant correlation (r = 0.644, p = 0.00002). Accumulation of p53 was significantly more elevated in HPV 16-infected lesions (r = 0.518, p = 0.00001) and E6-expressing cells (r = 0.650, p = 0.000004). Only 12 of the 230 cases analyzed showed presence of the mutant p53 protein. Angiogenesis appears to increase with histological abnormality in the uterine cervix. Angiogenesis also appears to be influenced by high risk HPV infection, the expression of the E6 transforming protein and the p53 tumour suppressor protein. PMID:10220796

  16. The application of uterine artery embolization for the treatment of uterine scar pregnancy after cesarean section

    International Nuclear Information System (INIS)

    Objective: To assess the clinical value of uterine arterial embolization (UAE) in treating uterine scar pregnancy after cesarean section. Methods: A total of' 35 cases with cesarean scar pregnancy, admitted to authors' hospital during the period from Jan. 2007 to June 2011, were divided into two groups: embolization group (n=21) and non-embolization group (n=14). By using Seldinger technique, UAE was performed via the right femoral access and gelatin sponge particle was used as embolization agent to occlude the uterine artery. In embolization group, sixteen patients received uterine cavity curettage one or two days after UAE, while five patients received laparotomy or perineotomy surgery to remove the lesions after UAE. In non-embolization group, uterine cavity curettage was performed directly in 8 patients, local injection of' methotrexate followed by uterine cavity curettage was carried out in 3 patients, and direct laparotomy to remove the lesions was adopted in the remaining 3 patients. The blood loss during the procedure, the hospitalization days and the time for ?-HCG levels falling to normal were documented. The results were compared between the two groups. Results: UAE was successfully accomplished in all the 21 patients of embolization group and the uterus was preserved in all patients. For the embolization group, the mean hospitalization time was (11.5±3.6) days, and the time for ?-HCG levels falling to normal was (18.6±4.9) days. For the non-embolization group, the mean hospitalization time was(20.4±5.2)days, and the time for ?-HCG levels falling to normal was (28.7±5.6)days. Hysterectomy had to be carried out in two patients of non-embolization group due to the massive bleeding occurred in therapeutic procedures. Conclusion: For the treatment of cesarean scar pregnancy, UAE is very effective and mini-invasive with high success rate. UAE can preserve the patient's reproductive function, and it also plays a significant role in preventing hemorrhage and assisting hemostasis. (authors)

  17. Study of patient's position to reduce late complications in high dose rate intracavitary radiation of the uterine cervix cancer

    International Nuclear Information System (INIS)

    Radiation proctitis and radiation cystitis are frequent and problematic late complications in patients treated with radiation for the uterine cervix cancer. Authors tried to find out the better patient's position in high dose rate intracavitary radiation to reduce the radiation dose of bladder and rectum. In 13 patients, foley catheters were inserted to patients' bladder and rectum and were ballooned with radioopaque dye. After insertion of a tandem and two ovoids, semi-orthogonal anteroposterior and lateral films were taken in both lithotomy and supine position. The rectal point and bladder point were defined according to the criteria recommended in the ICRU Report 38 with modification. Using these films, all patients' bladder and rectal dose were calculated in both positions (the radiation dose of A point was set to 400 cGy). And also, the distance of bladder and rectum from uterine cervical os was calculated in both positions. The average radiation dose of rectum was 240.7 cGy in lithotomy position and 278.3 cGy in lithotomy position and 255.8 cGy in supine position. After the paired t-test, the radiation dose of rectum in lithotomy position was marginally significantly lower than that in supine position, while the radiation dose of bladder in lithotomy position was significantly higher than that in supine position. On the other hand, the average distance between rectum and cervical os was 35.2 mm in lithotomy position and 32.3 mm in supine position and the average32.3 mm in supine position and the average distance between bladder and cervical os was 30.4 mm in lithotomy position and 34.0 mm in supine position. After the paired t-test, the distance between rectum and cervical os in lithotomy position was significantly longer than that in supine position, while the distance was significantly longer than that in supine position, while the distance between bladder and cervical os in lithotomy position was significantly shorter than that in supine position. The radiation dose of bladder can be reduced in supine position and the radiation dose of rectum can be reduced in lithotomy position, so we can choose appropriate position in each patient

  18. Volumetric Imaging by Megavoltage Computed Tomography for Assessment of Internal Organ Motion During Radiotherapy for Cervical Cancer

    International Nuclear Information System (INIS)

    Purpose: To assess the internal organ motion of the cervix and uterus by megavoltage computed tomography (MVCT) during intensity-modulated radiotherapy (IMRT). Methods and Materials: Ten patients with Stage IIB-IVA cervical cancer underwent daily MVCT imaging. Internal organ motion was evaluated on 150 pretreatment MVCT images by measuring shifts in their boundaries between the MVCT and kilovoltage (kV) planning CT scan in the anterior, posterior, left and right lateral, and superior and inferior direction. Additional intrafractional patient movement was evaluated on 50 posttreatment MVCT images. Results: Measured cervical motion (mean ± SD) was 0.4 ± 10.1 mm in the anterior, -3.0 ± 6.9 mm in the posterior direction, -3.5 ± 4.9 mm in the left and 0.2 ± 4.5 mm in the right lateral direction, 2.2 ± 8.0 mm in the superior and 0.5 ± 5.0 mm in the inferior direction. Compared to the cervix, larger uterine motion was observed. Patient movement during treatment was limited to 1.1 ± 1.3 mm, -0.3 ± 1.6 mm, and 0.2 ± 2.3 mm in anteroposterior, laterolateral and superoinferior direction respectively. Conclusions: MVCT imaging can be used to study patient setup accuracy and cervical and uterine motion during IMRT. This data may be used to refine treatment margins.

  19. Uterine restoration after repeated sloughing of fibroids or vaginal expulsion following uterine artery embolization

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hye Ri; Kim, Nack Keun; Lee, Mee Hwa [Pochon CHA University, Department of Obstetrics and Gynecology, Bundang CHA General Hospital, Sungnam-si, Kyonggi-do (Korea); Kim, Man Deuk; Kim, Hee Jin; Yoon, Sang-Wook [Pochon CHA University, Department of Diagnostic Radiology, Bundang CHA General Hospital, Sungnam-si, Kyonggi-do (Korea); Park, Won Kyu [Yeungnam University, Department of Diagnostic Radiology, Kyongson, Dyongbuk (Korea)

    2005-09-01

    The aim of our study is to present our experience with uterine restoration after repeated sloughing of uterine fibroids or transvaginal expulsion following uterine artery embolization (UAE) and to determine its safety and outcome. One hundred and twenty-four women (mean age, 40.3 years; age range, 29-52 years) with symptomatic uterine fibroids were included in this retrospective study. We performed arterial embolization with poly(vinyl alcohol) particles (250-710 {mu}m). Clinical symptoms and follow-up information for each patient were obtained through medical records. At an average of 3.5 months (range, 1-8 months) after embolization, magnetic resonance imaging examinations with T1- and T2-weighted and gadolinium-enhanced T1-weighted images were obtained for all patients. The mean follow-up duration was 120 days (90-240 days). Eight (6.5%) patients experienced uterine restoration after repeated sloughing of uterine fibroids or spontaneous transvaginal expulsion. The locations of the leiomyomas were submucosal (n=5), intramural (n=2) and transmural (n=1). The maximum diameter of the fibroids ranged from 3.5 to 18.0 cm, with a mean of 8.4 cm. The time interval from embolization to the uterine restoration was 7-150 days (mean 70.5 days). The clinical symptoms before and during vaginal sloughing or expulsion were lower abdominal pain (n=4), vaginal discharges (n=3), infection of necrotic myomas (n=2) and cramping abdominal pain (n=1). Gentle abdominal compression (n=1) and hysteroscopic assistance (n=1) were required to remove the whole fibroid. No other clinical sequelae, either early or delayed, were documented. Magnetic resonance images revealed the disappearance of leiomyomas, intracavitary rupture resulting in transformation of intramural or transmural myomas into submucosal myomas and localized uterine wall defects. Although the small size of this study precludes a strict conclusion, there appear to be few serious complications directly related to vaginal expulsion. Vaginal expulsion or fibroid sloughing is a possible course following UAE that is manageable, and the patients should be informed about this possibility. (orig.)

  20. Uterine restoration after repeated sloughing of fibroids or vaginal expulsion following uterine artery embolization

    International Nuclear Information System (INIS)

    The aim of our study is to present our experience with uterine restoration after repeated sloughing of uterine fibroids or transvaginal expulsion following uterine artery embolization (UAE) and to determine its safety and outcome. One hundred and twenty-four women (mean age, 40.3 years; age range, 29-52 years) with symptomatic uterine fibroids were included in this retrospective study. We performed arterial embolization with poly(vinyl alcohol) particles (250-710 ?m). Clinical symptoms and follow-up information for each patient were obtained through medical records. At an average of 3.5 months (range, 1-8 months) after embolization, magnetic resonance imaging examinations with T1- and T2-weighted and gadolinium-enhanced T1-weighted images were obtained for all patients. The mean follow-up duration was 120 days (90-240 days). Eight (6.5%) patients experienced uterine restoration after repeated sloughing of uterine fibroids or spontaneous transvaginal expulsion. The locations of the leiomyomas were submucosal (n=5), intramural (n=2) and transmural (n=1). The maximum diameter of the fibroids ranged from 3.5 to 18.0 cm, with a mean of 8.4 cm. The time interval from embolization to the uterine restoration was 7-150 days (mean 70.5 days). The clinical symptoms before and during vaginal sloughing or expulsion were lower abdominal pain (n=4), vaginal discharges (n=3), infection of necrotic myomas (n=2) and cramping abdominal pain (n=1). Gentle abdominal compression (n=1) and). Gentle abdominal compression (n=1) and hysteroscopic assistance (n=1) were required to remove the whole fibroid. No other clinical sequelae, either early or delayed, were documented. Magnetic resonance images revealed the disappearance of leiomyomas, intracavitary rupture resulting in transformation of intramural or transmural myomas into submucosal myomas and localized uterine wall defects. Although the small size of this study precludes a strict conclusion, there appear to be few serious complications directly related to vaginal expulsion. Vaginal expulsion or fibroid sloughing is a possible course following UAE that is manageable, and the patients should be informed about this possibility. (orig.)

  1. Transvaginal sonography combined with saline contrast sonohysterography in evaluating the uterine cavity in premenopausal patients with abnormal uterine bleeding

    DEFF Research Database (Denmark)

    Dueholm, M; Forman, Axel

    2001-01-01

    To evaluate whether saline contrast sonohysterography (SCSH) adds additional information to that obtained by transvaginal sonography (TVS) for predicting endometrial abnormality in premenopausal patients with abnormal uterine bleeding.

  2. Uterine Segmentation and Volume Measurement in Uterine Fibroid Patients’ MRI Using Fuzzy C-Mean Algorithm and Morphological Operations

    Directory of Open Access Journals (Sweden)

    Alireza Fallahi

    2011-11-01

    Full Text Available Background: Uterine fibroids are common benign tumors of the female pelvis. Uterine artery embolization (UAE is an effective treatment of symptomatic uterine fibroids by shrinkage of the size of these tumors. Segmentation of the uterine region is essential for an accurate treatment strategy.Objectives: In this paper, we will introduce a new method for uterine segmentation in T1W and enhanced T1W magnetic resonance (MR images in a group of fibroid patients candidated for UAE in order to make a reliable tool for uterine volumetry.Patients and Methods: Uterine was initially segmented using Fuzzy C-Mean (FCM method in T1W-enhanced images and some morphological operations were then applied to refine the initial segmentation. Finally redundant parts were removed by masking the segmented region in T1W-enhanced image over the registered T1W image and using histogram thresholding. This method was evaluated using a dataset with ten patients’ images (sagittal, axial and coronal views.Results: We compared manually segmented images with the output of our system and obtained a mean similarity of 80%, mean sensitivity of 75.32% and a mean specificity of 89.5%. The Pearson correlation coefficient between the areas measured by the manual method and the automated method was 0.99.Conclusions: The quantitative results illustrate good performance of this method. By uterine segmentation, fibroids in the uterine may be segmented and their properties may be analyzed.

  3. Expresión de Interferón Gamma (IFN-g), fFactor de Necrosis Tumoral alfa (TNF-a) e Interleucinas 2, 4 y 6 ( IL-2, IL-4, IL-6) en Células de Neoplasias Intraepiteliales de Cuello Uterino: Reporte Preliminar / Gamma Interferon (IFN-g), Tumor Necrosis Factor Alpha (TNF-a) and Interleukins 2, 4 and 6 (IL-2, IL-4, IL-6) in Cervical-Uterine Cells of Intraepithelial Neoplasia: A Preliminary Report

    Scientific Electronic Library Online (English)

    Tatiana, Pardo-Govea; Diana, Callejas; José, Núñez-Troconis; Mary, Araujo; Luciana, Costa; Héctor, Pons; Mariela, Delgado; Francisca, Monsalve.

    2005-03-01

    Full Text Available El presente estudio fue realizado para determinar la expresión de citocinas tipo Th1: IL-2 y IFN-gamma, y Th2: IL-4 e IL-6, así como del TNF-alfa en pacientes con lesiones premalignas del cuello uterino (CU) y su relación con la infección por el Virus del Papiloma Humano (VPH). Se estudiaron 30 paci [...] entes con lesiones pre-malignas del CU; NIC 1: 70%, NCI 2: 16,7% y NIC 3: 13,3%) y 9 controles con CU sanos. A cada paciente se le realizó una historia clínica, evaluación ginecológica que incluyó la toma de la citología cervico-vaginal (CCV) y biopsia de CU para estudio histológico e inmunológico. Se empleó la reacción en cadena de polimerasa (PCR) para el estudio del VPH. La expresión del IFN-gamma se encontró aumentada en pacientes con respecto al grupo control (5,06 ± 4,7 vs 0 media ± DS; p Abstract in english The purpose of this work was to determine the expression of type Th1 cytokines: IL-2 and IFNgamma, and Th2: IL-4 and IL-6, as well as TNF-alpha in patients with precancerous lesions of the uterine cervix and their relationship with the human papiloma virus (HPV). 30 patients with precancerous lesion [...] s (NIC 1: 70%, NIC 2: 16,7% and NIC 3: 1.3%) and 9 normal controls were studied. A clinical history, gynecological evaluation, cytology and an uterine biopsy were carried out in each patient and control. PCR was used for the diagnosis of HPV. IFN-gamma expression (positive cells/field) was increased in patients with NIC (5.06 ± 4.7 vs 0 in the control group; p

  4. Miomatosis uterina gigante Giant uterine myomatosis

    Directory of Open Access Journals (Sweden)

    Miguel Sarduy Nápoles

    2009-09-01

    Full Text Available El gran tamaño de algunos tumores ha sido descrito con asombro a través del tiempo. Entre ellos se incluyen los