ultraviolet irradiated mouse: Topics by WorldWideScience.org

Comparative action spectrum for ultraviolet light killing of mouse melanocytes from different genetic coat color backgrounds

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2011-02-01

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Suppression of pitting corrosion with passive film modification on type 304 stainless steel by ultra-violet light irradiation; Shigaikoshosha ni yoru Type 304 stainless ko no fudotai himaku kaishitsu to koshoku yokusei

The photobiology of mouse melanocyte lines with different pigment genotypes was studied by measuring colony-forming ability after irradiation. The cell lines were wild-type black (melan-a) and the mutants brown (melan-b) and albino (melan-c). Four lamps emitting various UV wavelengths were used. These were germicidal (UVC, 200-280 nm), 82.3% output at 254 nm, TL01 (UVB, 280-320 nm), 64.2% at 310-311 nm, FS20, broadband with peak output at 312 nm and Alisun-S (UVA, 320-400 nm), broadband with peak output at 350-354 nm. Appropriate filtration reduced the contaminating UVC to nonlethal levels for the longer waverange lamps. It is clear from these studies that, in pigment cells, monochromatic results cannot predict polychromatic responses and that cell death from solar irradiations is a complex phenomenon that depends on more than DNA damage. (author).

1997-01-01

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Structural and functional aspects of radiation adrenalopathy

In this study, the effects of 325nm wavelength ultraviolet light irradiation on pitting corrosion behavior of type 340 stainless steel in a neutral chloride solution are studied. Further, the change of passive film with the light irradiation is analyzed using x-ray photoelectron spectroscopy. The mains results obtained therefrom are stated below. Pitting potential can be shifted in noble direction by the ultraviolet light irradiation. The effect of ultraviolet light irradiation is ore prominent in the pitting corrosion process than that in the passive film formation. The result of the analysis in terms of the birth and death stochastic probability process shows that pitting corrosion rate is decreased remarkably by the ultraviolet light irradiation at the formation of passive film, while the ...

1998-06-20

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Effect of UV radiation on the killer phenotype in the wine yeast-saccharomycetes and spontaneous variation of this character

As part of a combined study of the responses of the mouse adrenal gland and kidney to X-irradiation, the weight of adrenal glands, the relative volumes of the cortex and medulla and the aldosterone output were measured at predetermined times after irradiation of the left organs only.

1986-01-01

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Synthesis of ultraviolet curable encapsulating adhesives and their package applications for organic optoelectronic devices

Spontaneous and ultraviolet-induced changeabilities of wine yeasts from the killer state to sensitive one have been studied. Observed often spontaneous changes of killer and neutral phenotypes under laboratory store conditions as well as high mutation frequency of genetic elements responsible for the killer indication on ultraviolet irradiation testify that often encounterability in nature and in the production of sensitive yeasts is attributed to high frequency of mutation changes of the killer and neutral phenotypes to the sensitive state.

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British Library Electronic Table of Contents (United Kingdom)

With conventional heating process, ultraviolet (UV) illumination, and microwave irradiation, we have successfully synthesized UV curable encapsulating adhesives with excellent gas barrier capabilities, good adhesive strength, moderate hardness, and high refractive indices. The experimental results manifest that the physical properties of lab-made encapsulating adhesives are highly dependent on their chemical structures and synthetic procedure. We also discover that the encapsulating adhesive prepared by microwave irradiation (i.e. encapsulating adhesive VI-MW) exhibits better adhesive strength and higher gas resistance than those prepared by conventional heating process and UV illumination. Furthermore, encapsulating adhesive VI-MW has also been applied for the package of organic light emi...

2011-01-01

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Toxicological safety evaluation of biomolecules and materials transformed by gamma irradiation

Cell death (apoptosis) in mouse intestine after continuous irradiation with gamma rays and with beta rays from tritiated water

In the bacterial reversion assay with S. typhimurium TA98, TA100, TA1535 and TA1537, gamma irradiated hyaluronic acid (10 and 50 kGy) did not induce a significant increase in the number of revertant colonies in the presence of S9 metabolic activation system. In chromosomal aberration tests with CHO cells, gamma irradiated hyaluronic acid (10 and 50 kGy) did not result in an increase in the frequency of chromosomal aberrations. In vivo mouse micronucleus assay, gamma irradiated hyaluronic acid (10 and 50 kGy) did not show an increase in the frequency of polychromatic erythrocytes with micronuclei. These results indicate that hyaluronic acids irradiated at 10 and 50 kGy did not show any genotoxic effects under these experimental conditions. In order to evaluate their possible subacute toxicity, the male and female of ICR mouse were given to methanol extract of 50 ...

2010-01-15

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Lamp system for uniform semiconductor wafer heating

Apoptosis is a pattern of cell death involving nuclear pycnosis, cytoplasmic condensation, and karyorrhexis. Apoptosis induced by continuous irradiation with gamma rays (externally given by a 137Cs source) or with beta rays (from tritiated water injected ip) was quantified in the crypts of two portions of mouse bowel, the small intestine and descending colon. The time-course change in the incidence of apoptosis after each type of radiation could be explained on the basis of the innate circadian rhythm of the cells susceptible to apoptotic death and of the excretion of tritiated water (HTO) from the body. For 6-h continuous gamma irradiation at various dose rates (0.6-480 mGy/h) and for 6 h after injection of HTO of various radioactivities (0.15-150 GBq per kg body wt), the relationships between dose and incidence of apoptosis were obtained. Survival curves were then constructed from the curves for dose vs incidence of ...

1989-04-01

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The wavelength dependence of ultraviolet enhanced reactivation in a mammalian cell-virus system

A lamp system with a very soft high-intensity output is provided over a large area by water cooling a long-arc lamp inside a diffuse reflector of polytetrafluorethylene (PTFE) and titanium dioxide (TiO.sub.2) white pigment. The water is kept clean and pure by a one micron particulate filter and an activated charcoal/ultraviolet irradiation system that circulates and de-ionizes and biologically sterilizes the coolant water at all times, even when the long-arc lamp is off.

2001-01-01

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Spectroscopy of color centers in yttrium-aluminium perovskite crystals

The effect of UV radiation in the wavelength region 230 nm to 302 nm on the ability of an irradiated mammalian cell to reactivate UV-irradiated mammalian virus was tested. An action spectrum for radiation enhanced reactivation (RER) is presented. The shape of the action spectrum points to a combined nucleic acid-protein target for UV radiation effects on this cellular parameter. An analysis of the results of others involving the biochemical and photobiological events involved in RER does not allow us to distinguish which macromolecule is the major contributor to this effect. Studies involving an analogous phenomenon in bacteris (Weigle reactivation) imply that RER and WR amy involve similar mechanisms. (author).

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X-ray and UV-light irradiation effects on oxide superconducting thin films

The color centers, which are generated in yttrium-aluminium perovskite (YAP):Nd(1 at.%) and YAP:Er(50 at.%) crystals under the influence of ultraviolet and #gamma#-irradiation, have been studied by absorption spectroscopy. The generated color centers are both stable and transient at room temperature. It is shown that the transient color centers are mainly responsible for the decrease of laser generation efficiency of Nd:YAP and YAP:Er irradiated crystals, although physical mechanisms leading to efficiency decrease are different in these materials. (orig.)

1998-07-24

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Radiation-induced mutations at mouse hemoglobin loci

Oxide superconducting thin films were irradiated with X-rays and ultra-violet (UV) light, and induced radiation effects on electrical and chemical properties were examined by transport measurement, X-ray diffraction analysis (XRD), diamagnetization measurement and X-ray photoemission spectroscopy (XPS). After irradiation for ErBa_2Cu_3O_x films with X-rays emitted from a Rh tube for 100 hours, superconductivity was remarkably damaged, destroying the zero-resistance state. The UV-light irradiation for Bi_2Sr_2CaCu_2O_x films was performed in He gas of about 500 Pa with a low pressure mercury lamp. The superconductivity was gradually degraded with the UV irradiation time up to 70 minutes. In both cases, adequate oxygen-annealing treatments restored superconductivity. The X-ray photoemission spectra showed that the mean Cu valence of the films was decreased approximately from +2 to +1 ...

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Study of proton therapy on malignant tumors. Effects in twenty-four hours after proton irradiation

In experiments designed to detect new mutations affecting hemoglobin, we irradiated the male or female parent in reciprocal crosses of two mouse strains that differ in alleles at the hemoglobin (Hba, Hbb) loci as well as at five other specific loci. Offspring were analyzed for hemoglobin properties (electrophoretic pattern, solubility, crystal pattern), serum albumin differences, erythrocyte lysis, reticulocyte count, and external appearance. Five hemoglobin variants were found among the mutants. In three, the genetic contribution from the irradiated father was not expressed with regard to the #alpha#-chain; one carried a tandem duplication (the first known case in the mouse) involving Hbb; and one probably resulted from double nondisjunction of chromosome 7. The finding that major chromosome aberratios can mimic hemoglobin mutations indicates the need, in similar experiments, to follow F_1 screening ...

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Toxicity of ultraviolet-irradiated halothane in mice

We irradiated proton beams on the ears of rabbits and the Harding-Passey mouse melanoma and observed their morphological change. We used 52 MeV proton beams from the INS-FM cyclotron. We adjusted the energy of the proton beams to be at the plateau part of the Bragg curve, at the half-way point of the Bragg peak, and at the Bragg peak. The amount of radiation was 5000rad in each case. The Harding-Passey mouse melanoma was transplanted into the subcutan of a three week old mouse. In this experiment, we used tumors, the diameter of which grew up to 1.5-2cm in 2-3 weeks after the transplantation. Using the jroscope, we observed both lightly and severely damaged cells. Using proton irradiation with the Bragg peak located at depth of 1mm in the rabbit's ears, we studied the change in the tissue. Irradiated epidermis fell off and was eroded because of ...

1983-01-01

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Ionizing radiation alters beta-endorphin-like immunoreactivity in brain but not blood

One such agent is the widely used anesthetic, halothane. To study the toxicity of u.v. decomposed halothane, mice were exposed to anesthetic concentrations (1.3%) of non- and u.v.-irradiated halothane in oxygen for 90 min. Halothane sleeping times increased from 14.3 min to 72.5 min. Microsomal mixed function oxidase activity decreased, as shown by prolonged pentobarbital sleeping times 1 day after exposure to halothane and irradiated halothane (54.6 min and 149.1 min, respectively, as compared to a 34.6-min control). Quantitative and qualitative differences were found in the amount of (/sup 14/C)-pentobarbital metabolites excreted by u.v. irradiated halothane-exposed mice compared to either oxygen or non-irradiated halothane-exposed groups. In addition, serum glutamic-oxalacetic transaminase (SGOT) of irradiated halothane-exposed mice increased to 233% of the control values, and ...

1982-01-01

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Solid-state ozone synthesis by energetic ions

Previous behavioral and pharmacological studies have implicated endorphins in radiation-induced locomotor hyperactivity of the C57BL/6J mouse. However, the endogenous opiate(s) responsible for this behavioral change have not been identified. The present study measured beta-endorphin-like immunoreactivity (beta-END-LI) in brain, blood, and combined brain and pituitary samples from irradiated and sham-irradiated C57BL/6J mice. After radiation exposure, levels of beta-END-LI decreased significantly in the brain. A similar, but not statistically significant, decline was measured in combined brain and pituitary samples. Concentrations of blood beta-END-LI were not changed by irradiation. These radiogenic changes in beta-END-LI are in some ways similar to those observed after other stresses. However, radiation-induced locomotor hyperactivity may be mediated more by alterations of beta-END-LI in the brain than ...

1983-12-01

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Effects of gamma irradiation on medicinal plants and spices (2): Piper cubeba, piper nigrum, piper retrofractum, amomum cardamomum, and myristica fragrans

We have synthesized ozone by irradiating thin solid films of oxygen and oxygen-water mixtures with 100 keV protons, motivated by recent reports of condensed O_3 on icy satellites in the outer Solar system. We measured the depth of the Hartley absorption band in the ultraviolet by reflectance spectroscopy and used it to quantify the column density of ozone. We analyzed the results using a three-component (O, O_2 and O_3) model that successfully explains the fluence dependence of ozone production.

1999-08-02

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Flowcytometry of {gamma}-ray irradiated mouse ovary

Effects of gamma irradiation on essential oils of five medicinal plants i.e. dried seeds of piper cubeba(cubeb), piper nigrum(black pepper), piper retrofractum, amomum cardamomum(cardamom) and myristica fragrans(mace), packed in low density polyethylene bag of 0.13 mm thickness have been investigated. After being irradiated at doses of 5 and 10 kGy, a part of the samples was analysed, and the rest were stored for six months at temperature of 30 +- 2 degC, and humidity ranging from 70 to 95%. The essential oil characteristics of control, irradiated and six month stored samples were analysed using infrared and ultraviolet spectrophotometers, HPLC, GLC and refractometer. Other parameters observed were moisture content and essential oil content of the samples. Results showed that irradiation up to a dose of 10 kGy do not give any significant effect on these parameters. Significant ...

1983-12-01

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Effects of cell concentrations on the survival and repopulation of haemopoietic stem cells in irradiated bone marrow cell culture in vitro

This study was carried out to evaluate the biochemical and morphological effects of ionizing radiation on ovary. Immature mice (ICR, 3 week-old) were irradiated at a dose of LD{sub 80(30)} at KAERI. The ovaries were collected after 6 hours, 12 hours, 1 day, and 2 days post irradiation. To analyze the morphological changes, histological staining with hematoxylin-eosin, immuno- histochemical preparation using in situ 3'-end labeling was performed. DNA fragmentation analysis and flowcytometric evaluation of DNA extracted from whole ovary were performed. As a result of DNA fragmentation analysis, DNA fragments with 185, 370, and 555 base pairs were clearly shown at 6 hours post irradiation. The percentage of A{sub 0} cell cycle was significantly increased in the irradiated group than control. In situ 3'-end labeled follicles were increased at 6 hours post irradiation. ...

1998-10-01

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Photosensitization by drugs. [Ultraviolet radiation

Effects of cell concentrations on the survival and repopulation of haemopoietic stem cells after irradiation were studied in the long-term culture of mouse bone marrow cells in vitro. No difference was observed in the survival of the stem cells among cultures in which 0 - 10/sup 7/ cells were re-inoculated on the adherent cell colonies in the culture flask. Stem cells showed a significant proliferation within 1 week and the number of the stem cells exceeded the control in 3 weeks after irradiation in the cultures with less than 10/sup 6/ re-inoculated cells per flask. In contrast, there was a considerable delay in the onset of stem cell proliferation after irradiation in the culture with 10/sup 7/ cells per flask. Based on these results, a possibility that a stimulator of stem cell proliferation, released from irradiated stromal cells, is cancelled by an inhibitory factor produced ...

1981-12-01

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Mechanism of the accumulation effect in laser damage to polymers: appearance of microdamage due to an ionization absorption wave

uv irradiation (365 nm) of air-saturated methanol solutions of 20 drugs absorbing in the 300 to 400 nm region gave rise to oxygen uptake, as determined with a polarographic oxygen electrode. The drugs were tested for photosensitizing capability by either a Type I (free radical) or a Type II (single molecular oxygen) mechanism. This testing was done by the inclusion of either acrylamide or 2,5-dimethylfuran in the irradiated drug solution, with observation of the subsequent polymerization or oxidation, respectively. Phenothiazine and thiazide derivatives appear capable of photosensitization by both mechanisms; promethazine, trifluoperazine, and furosemide show relatively high reactivity. Diazepam (weak), hexachlorophene, aminacrine, pyrilamine, tetracycline, demeclocyline, quinine, and anthracene (strong) react only by a Type II mechanism, with a photosensitizing efficiency increasing in the order given. A correlation appears to exist with ...

1977-09-01

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Cytotoxic effects of WR-2721 on mouse testicular cells

An investigation was made of the accumulation of laser damage to transparent polymers irradiated with nanosecond pulses from neodymium and ruby lasers. The damage was investigated by the method of scattering and luminescence in the visible and near ultraviolet parts of the spectrum. It was established that there were two stages in laser damage by repeated irradiation with pulses of intensity below the single-shot damage threshold. An absorbing defect evolved during the first stage in such a way as to create a thermal instability in the surrounding matrix. During the second stage this thermal instability caused spatial growth of laser damage because of propagation of an ionization-inducing absorption wave with a front traveling at the rate governed by the electron component of the thermal conductivity.

1984-04-01

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Some relationships between ultraviolet light and heme-protein-induced peroxidative lipid breakdown in liposomes, as reflected by fluorescence changes: the effect of negative surface charge

WR-2721 (S-2-(3-aminopropylamino)ethylphosphorothioic acid) has been demonstrated to be cytotoxic to stem spermatogonia in the mouse. Five and 10 injections of 300 mg/kg killed sufficient numbers of stem cells to reduce sperm production 56 days after treatment by 16 and 43%, respectively. Single injections of 300 or 400 mg/kg of WR-2721 given 15 min after irradiation produced negligible toxicity to stem cells as measured by counts of repopulated tubules; 600 mg/kg reduced stem cell survival by 47%. Four daily injections of 300 mg/kg given 4, 3, 2, and 1 days prior to irradiation reduced stem cell survival by about 60%. The cytotoxic effects of WR-2721 on testicular stem cells at least partially explains the reduced protection factors observed in the testis with low doses of radiation and during fractionated treatments involving multiple injections of drug.

1984-09-01

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Laser Photobiomodulation of Wound Healing: A Review of Experimental Studies in Mouse and Rat Animal Models

The water soluble, photolabile nitrene precursor, azidonaphthalene-2,7-disulfonic acid (ANDS) was encapsulated in small unilamellar, isoelectric (egg PC) or negatively charged (egg PC + dihexadecylphosphate) liposomes. The individual and combined effects of heme-proteins and UV irradiation on the fluorescence of these vesicles under aerobic conditions were studied. Consistent with the catalytic action of heme-proteins on lipid peroxidation and peroxide decomposition, addition of cytochrome c (positively charged) or catalase (negatively charged) to the vesicles elicited immediate formation of a fluorescence band at 470 nm, characteristic of Schiff bases that form from aldehyde byproducts of decomposing hydroperoxides. Ultraviolet irradiation of liposomes caused no significant changes in the fluorescence spectrum, in spite of the radiolysis of ANDS inside the vesicles with consequent formation of nitrene radicals. When ...

25

British Library Electronic Table of Contents (United Kingdom)

Abstract Objectives: This investigation reviewed experimental studies of laser irradiation of wound healing in mice and rats published from 2003 to August 2008, respectively, to assess putative stimulatory effects of this treatment. Background: Animal models, including rodents, attempt to reflect human wound healing and associated problems such as dehiscence, ischemia, ulceration, infection, and scarring. They have played a key role in furthering understanding of underlying mechanisms involved in impaired wound healing, and in testing new therapeutic strategies including laser irradiation. Method: Original research papers investigating effects of laser or monochromatic light therapy on wound healing in mice and rats and published from January 2003 to August 2008 were retrieved from library...

2010-01-01

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Functional strategies of the hindlimb muscles in the mouse deer

Effects of amifostine on radiation-induced apoptosis in mouse ovary

... were larger in TFLM, BFM, QFM, PM and TSM in the mouse deer than in the two ... ...

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Wastewater treatment; Abwasserreinigung

The present study was designed to assess the radioprotective effects of amifostine on ovarian follicles. Three week-old female mice with or without pretreatment of amifostine were irradiated with 6.42 Gy of #gamma# -ray. Ovaries were collected 0 and 6h after irradiation. DNA fragmentation pattern and expression of genes and activity of proteins related with apoptosis were investigated by means of RT-PCR and Western blot. Proliferation of granulosa cells was reduced and incidence rate of follicular atresia was increased in ovarian follicles in #gamma# -ray irradiated mice compared to those in control or amifostine-treated group. DNA fragmentation was increased in time-dependent manner in granulosa cells of all irradiated groups. However, no difference between amifostine pre-treated group and irradiated groups was found and the expression of p53 as tumor suppressor gene and Bax as one ...

2002-10-20

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Schottky barrier modulation on silicon nanowires

The methods introduced for the field of cleaning waste water can be classified under various processes. Chemical oxidation is done with ozone, hydrogen peroxide and ultraviolet irradiation with subsequent biological decomposition. Another method is ultra-filtration with recovery of valuable materials or waste water ponds with algae biomass to decompose ammonium compounds, nitrates and phosphates. (EF) [Deutsch] Die auf dem Gebiet der Abwasserreinigung vorgestellten Methoden kann man in verschiedene Verfahren einordnen. Die chemische Oxidation erfolgt mit Ozon, Wasserstoff-Peroxid, UV Bestrahlung und anschliessenden biologischen Abbau. Eine andere Methode ist die Ultrafiltration mit Rueckgewinnung von Wertstoffen oder Abwasserteiche mit Algenbiomasse zum Abbau von Ammoniumverbindungen, Nitraten und Phosphaten. (EF)

1994-11-01

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Advanced oxidation process based on ozone/electron beam irradiation for treating groundwater

Oxide charge on the sidewalls of SiO{sub 2} embedded silicon wires with 20x20 nm{sup 2} cross section is shown to influence the Schottky barrier height for Pd{sub 2}Si/Si junctions positioned on the end surfaces of the wires. Compared with results on planar silicon surfaces, the electron barrier height is 0.3 eV lower for wires investigated as fabricated. By increasing the oxide charge through irradiation by ultraviolet light, the electron barrier decreases by an additional 0.15 eV and the hole barrier correspondingly increases by about the same amount. The phenomenon is explained by assuming an oxide charge density in the range of 10{sup 12} cm{sup -2}.

2007-03-26

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RBE and OER measurements on the p(66)+Be neutron beam at Faure, South Africa

There are several methods of generating OH free radicals from ozone and/or hydrogen peroxide and ultraviolet light. They all have in common that the OH free radicals originate in one single source only whereas in the combination of ozone with ionizing radiation two simultaneous working sources for the OH free radicals exist. The resulting higher OH free radical concentration makes this process especially apt for the remediation of low level contaminated groundwater as for example trichloroethylene (TCE) contamination in the sub-ppm range. A cost comparison between O_3/UV and O_3/electron beam for remediation of a groundwater contaminated with 100 ppb TCE indicated that for a throughput of about 5 million gallons/day the O_3/electron beam process is more cost-effective. (authors).

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Organ culture of mammalian skin and the effects of ultraviolet light and testosterone on melanocyte morphology and function

Results reported are for single dose exposures and refer to "6"0Co-#gamma#-irradiation. The RBE determined by V79 cell survival and based on the Do ratio was found to be 1.70#+-#0.4 ranging from 1.5 to 1.8. In the case of the regeneration of mouse jejunal crypts the RBE was calculated at ten cell curvival and was found to be 1.68. The maximum acute mouse skin reaction at a skin score of 2.0 was found to be 2.1 while the average skin reaction was 1.7. Growth retardation of Vicia faba bean roots measured at the level of 50% indicated an average RBE of 3.0 and a range of 2.7 to 3.7. The OER obtained for V79 cell survival was found to be 1.7 to 1.8. Comparison is made with the RBE and OER measurements for the neutron facilities at Clatterbridge, Fermilab and Louvain-la-Neuve which produce neutrons by the same nuclear reaction and whose physical specifications closely resemeble those of the Faure neutrons. This comparison ...

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An in vitro model to test relative antioxidant potential: Ultraviolet-induced lipid peroxidation in liposomes

Scrotal skin of black Long-Evans rats and human thigh skin were maintained in vitro as organ cultures for as long as 14 days, and examined histologically using the combined skin splitting and Dopa techniques. Selected rat skin cultures received testosterone in the culture medium and/or were irradiated with ultraviolet light (290 to 320 nm uvl). With increased time in culture, scrotal melanocytes round up and there is an increase in epidermal pigmentation. Human skin behaves similarly; after eight days in vitro human melanocytes also become rounded, but remain strongly Dopa-positive. Addition of exogenous testosterone to cultured rat skin maintains dendritic morphology of melanocytes, but cell body size is still reduced. uvl irradiation stimulates melanocytes in rat skin cultures, maintaining their dendritic morphology and increasing epidermal and dermal pigmentation. Cultured skin receiving both uvl and testosterone ...

1978-05-01

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Life span of multipotential hematopoietic stem cells in vivo

Since antioxidants have been shown to play a major role in preventing some of the effects of aging and photoaging in skin, it is important to study this phenomenon in a controlled manner. This was accomplished by developing a simple and reliable in vitro technique to assay antioxidant efficacy. Inhibition of peroxidation by antioxidants was used as a measure of relative antioxidant potential. Liposomes, high in polyunsaturated fatty acids (PUFA), were dispersed in buffer and irradiated with ultraviolet (UV) light. Irradiated liposomes exhibited a significantly higher amount of hydroperoxides than liposomes containing antioxidants in a dose- and concentration-dependent manner. Lipid peroxidation was determined spectrophotometrically by an increase in thiobarbituric acid reacting substances. To further substantiate the production of lipid peroxides, gas chromatography was used to measure a decrease in PUFA substrate. In order ...

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Molecular events involved in ionizing radiation induced skin carcinogenesis

The findings reported in this study highlight several important features of the development of hematopoietic stem cells after transplantation into irradiated recipients. First, they demonstrate the existence of a class of primitive multipotential stem cells that can function for a significant portion of the lifetime of a mouse (15 mo). In addition, they clearly show that these primitive stem cells can be infected with recombinant retroviruses and thus would be appropriate targets for gene therapy in somatic tissues. Second, our data indicate that the progeny of some, but not all, of the primitive stem cells have fully expanded into the various hematopoietic lineages by 2 mo after reconstitution. Finally, our analysis of the secondary recipients provides strong evidence suggesting that the primitive stem cell population can actually clonally expand. Our current experiments are aimed at determining the extent to which this expansion can occur and ...

1990-05-01

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Ultraviolet dosimetry characterization from calcium doped borate glass-ceramic

The process of mouse skin tumor formation is subdivided into three operational stages. These stages include initiation, promotion and progression. Ionizing radiation has been found to be a weak initiating agent in the production of malignant squamous cell carcinomas, a complete carcinogen and an agent effective in causing tumor progression. Four skin tumor histologies have been seen with ionizing radiation: benign papillomas, squamous (SCC) and basal (BCC) cell carcinomas and fibrosarcomas. Distinct non-ras transforming genes have been detected in radiation initiated SCCs. A benign papilloma cell line (308) was used as a model system to study ionizing radiation induced progression. A variant 308 cell line (308 10 Gy 5) derived by irradiation of the parental 308 cell has been characterized. The 308 10 Gy 5 cells unlike the parental 308 cells from malignant tumors in athymic nude mice upon subcutaneous injection. The variant 308 10 Gy 5 cells ...

36

Evolution of ultraviolet dwarfs

No abstract prepared.

2006-07-01

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Ovarian cancer mouse models: a summary of current models and their limitations

UV dwarf star evolution, using central and gap star models emphasizing photoneutrino emission

1969-01-01

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Variation in the sensitivity of the mouse spermatogonial stem cell population to fission neutron irradiation during the cycle of the seminiferous epithelium

Development of mouse models representing human spontaneous ovarian cancer has been hampered by the lack of understanding of the etiology of this very complex disease. Mouse models representing the different...Full Text Available

39

Cancer gene discovery in mouse and man

Dose-response studies of the radiosensitivity of spermatogonial stem cells in various epithelial stages after irradiation with graded doses of fission neutrons of 1 MeV mean energy were carried out in the Cpb-N mouse. These studies on the stem cell population in stages IX-XI yielded simple exponential lines characterized by an average D0 value of 0.76 +/- 0.02 Gy. In the subsequent epithelial stages XII-III, a significantly lower D0 value of 0.55 +/- 0.02 Gy was found. In contrast to the curves obtained for stem cells in stages IX-III, the curves obtained in stages IV-VIII indicated the presence of a mixture of radioresistant and radiosensitive stem cells. In stage VII, almost no radioresistant stem cells appeared to be present and a D0 value for the radiosensitive stem cells of 0.22 +/- 0.01 Gy was derived. Previously, data were obtained on the size of colonies (in number of spermatogonia) derived from surviving stem cells. Combining these ...

1986-12-01

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Structural transformations in Sc/Si multilayers irradiated by EUVlasers

AbstractThe elucidation of the human and mouse genome sequence and developments in high-throughput genome analysis, and in computational tools, have made it possible to profile entire...Full Text Available

2009-12-01

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41

Investigations of the green- and infrared-stimulated luminescence using the recuperation effect

Multilayer mirrors for the extreme ultraviolet (EUV) are keyelements for numerous applications of coherent EUV sources such as newtabletop lasers and free-electron lasers. However the field ofapplications is limited by the radiation and thermal stability of themultilayers. Taking into account the growing power of EUV sources thestability of the optics becomes crucial. To overcome this problem it isnecessary to study the degradation of multilayers and try to increasetheir temporal and thermal stability. In this paper we report the resultsof detailed study of structural changes in Sc/Simultilayers when exposedto intense EUV laser pulses. Various types of surface damage such asmelting, boiling, shockwave creation and ablation were observed asirradiation fluencies increase. Cross-sectional TEM study revealed thatthe layer structure was completely destroyed in the upper part ofmultilayer, but still survived below. The layers adjacent tothe substrateremained intact even ...

2007-08-21

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Investigations of the green- and infrared-stimulated luminescence using the recuperation effect

We used the recuperation effect (see also 'Recuperation of infrared stimulated luminescence of feldspars' in this issue) for investigating the connection between infrared- and greenlight-stimulated luminescence (IRSL and GLSL) of feldspars by performing a 'double-bleach recuperation' experiment. A diode system was used for infrared (IR) stimulation, and a filtered-light unit for greenlight (GL) stimulation. Powdered feldspar samples (2 mg each) of known chemical characterisation from a mineral collection were used. After beta-irradiation with 180 Gy and storage in the dark for several weeks feldspar aliquots were bleached down to a residual level of {approx}1% of the initial level, first with IR and subsequently with GL. For both stimulations, detection of the stimulated luminescence was carried out in the near ultraviolet region (around 260-360 nm, peaked at 340 nm). Other aliquots were bleached in reverse ...

2000-12-15

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Radiation 2006. In association with the Polymer Division, Royal Australian Chemical Institute. Incorporating the 21st AINSE Radiation Chemistry Conference and the 18th Radiation Biology Conference, conference handbook

We used the recuperation effect (see also 'Recuperation of infrared stimulated luminescence of feldspars' in this issue) for investigating the connection between infrared- and greenlight-stimulated luminescence (IRSL and GLSL) of feldspars by performing a 'double-bleach recuperation' experiment. A diode system was used for infrared (IR) stimulation, and a filtered-light unit for greenlight (GL) stimulation. Powdered feldspar samples (2 mg each) of known chemical characterisation from a mineral collection were used. After beta-irradiation with 180 Gy and storage in the dark for several weeks feldspar aliquots were bleached down to a residual level of #approx#1% of the initial level, first with IR and subsequently with GL. For both stimulations, detection of the stimulated luminescence was carried out in the near ultraviolet region (around 260-360 nm, peaked at 340 nm). Other aliquots were bleached in reverse order (1st GL, 2nd IR). These ...

2000-12-15

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Two and 8-azido photoaffinity probes. 2. Studies on the binding process of 2-5A synthetase by photosensitive ATP analogues

Full text: The general population is daily exposed to chronic, low doses of ionizing radiation (IR) from both natural and artificial sources. The biological consequences of acute, high dose IR exposure can be readily determined; however, the nature and significance of low dose, low dose-rate IR effects are still the subject of debate. Confounding the issue, are the phenomena collectively referred to as the Radiation-induced Bystander Effect (RIBE). The RIBE describes a collection of in vitro observations that suggest the presence of a soluble, transmissible factor(s) released from irradiated cells that can induce a biological response in un-irradiated cells. The induction, nature and magnitude of the RIBE varies between cell culture systems, radiation sources and end-points measured. Efforts to confirm the presence of the RIBE in vivo have been confined to in vivo-like culture systems and limited work with tumour and bone-marrow transplantation ...

2006-01-01

45

Identification of a nucleoside triphosphate binding site on calf thymus RNA polymerase II

The photoaffinity probes [#gamma#-"3"2P]2-azidoATP (2-N_3ATP) and [#alpha#-"3"2P]8-azido-ATP (8-N_3ATP) were used to investigate the binding of ATP to highly purified 2-5A synthetase. 2-N_3APT and 8-N_3ATP are substrates for 2-5A synthetase. In this study the authors show that 2- and 8-N_3ATP are competitive inhibitors of the enzymatic conversion of ATP to 2-5A. Ultraviolet irradiation results in the photoinsertion of 2-N_3ATP and 8-N_3ATP into the enzyme. The covalent photoinsertion of [#alpha#-"3"2P]8-N_3ATP into the 2-5A synthetase is proportional to the inactivation of the enzyme as UV irradiation is increased. Photolabeling of 2-5A synthetase is saturated at 1.5 mM 2-N_3ATP and 2.0 mM 8-N_3ATP. Computer analysis of the curvilinear Scatchard plots of the 2-5A synthetase suggest the presence of high-affinity and low-affinity binding sites that may correspond to the acceptor and the 2'-adenylation sites of the enzyme. The ...

46

The extracellular calcium sensing receptor is expressed in mouse mesangial cells and modulates cell proliferation.

A nucleoside triphosphate binding site on calf thymus RNA polymerase II was identified by using photoaffinity analogues of adenosine 5'-triphosphate and guanosine 5'-triphosphate. Both radiolabeled 8-azidoadenosine 5'-triphosphate (8-N3ATP) and radiolabeled 8-azidoguanosine 5'-triphosphate (8-N3GTP) bound to a single polypeptide of this enzyme. This polypeptide has a molecular mass of 37 kilodaltons and an isoelectric point of 5.4. Ultraviolet (UV) irradiation was necessary for photolabeling to occur. In addition, no labeling occurred when the probe was prephotolyzed or when the enzyme was inactivated. Furthermore, photolabeling of the enzyme could be decreased by preincubation with natural substrates. To provide evidence that the radiolabeled polypeptide forms a part of the domain of the nucleoside triphosphate binding site, experiments were performed using unlabeled 8-N3ATP. Although this unlabeled analogue ...

1986-01-14

47

Post-transcriptional and post-translational regulation during mouse oocyte maturation

Full Text Available

2005-10-01

48

High-Resolution MRI Study on Mouse Brain Using Micro-Imaging

Full Text Available

2011-03-01

49

Expression of microtubule associated protein of low molecular weight (TAU) in mouse brain development

Full Text Available

2008-12-01

50

Photosynthetic Response of Seagrasses to Ultraviolet-A Radiation and the Influence of Visible Light Intensity ¹

Published in summary form only.

51

A Proteomic Analysis of Leaf Responses to Enhanced Ultraviolet-B Radiation in Two Rice (Oryza sativa L.) Cultivars Differing in UV Sensitivity

Inhibition of photosynthesis by ultraviolet-A radiation (UV-A, 315-380 nanometers) was examined in three marine angiosperms: Halophila engelmannii Aschers, Halodule wrightii...Full Text Available

1982-02-01

52

Radiation, adriamycin, and skin reactions: effects of radiation and drug fractionation, hyperthermia, and tetracycline. [X rays

Full Text Available

53

Influence of the circadian rhythm in cell division on radiation-induced mitotic delay in vivo

The effect of adriamycin in combination with radiation on the skin reactions of mouse feet has been examined under a variety of experimental conditions including: (a) hyperthermic treatment of the foot immediately following adriamycin administration, with the former given either just before or just after x irradiation, and (b) fractionated treatments of drug and radiation in a variety of sequences over an 18-day period. In the case of the most severe hyperthermic treatment, no increased radiation reactions were observed in the presence of adriamycin. However, in the case of the less severe hyperthermic treatment a small but significant increase in skin reactions was observed. In the study of fractionated drug and radiation treatments, an enhancement of reaction in those animals receiving combined modality treatment over those receiving radiation alone was seen in those groups where the initiation of drug treatment succeeded the initiation of ...

1981-06-01

54

The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics

Mitotic delay is described as a classical response to radiation; however, circadian rhythmicity in cell division in vivo has not been considered by many authors. The present study investigated the relation between fluctuations reported as mitotic delay and recovery in vivo and circadian oscillations in mitotic index in mouse corneal epithelium. One aspect involved single doses (approximately 600 rad) given to mice at different circadian stages. The normal circadian rhythm in cell division was never obliterated. Inhibition of mitosis was evident but unpredictable, ranging from 6 to 15 hr after irradiation. Recovery was evident only during the daily increase in mitotic index of controls. The classical interpretation of recovery from mitotic delay may be in an in vitro phenomenon not reflecting in vivo responses, which are apparently strongly circadian stage dependent. The second portion of the study demonstrated a dose-response effect on length ...

1982-01-01

55

Technical approaches for mouse models of human disease

Mouse genetic resources include inbred strains, recombinant inbred lines, chromosome substitution strains, heterogeneous stocks, and the Collaborative Cross (CC). These resources were generated through...Full Text Available

2007-07-01

56

Social Deficits, Stereotypy, and Early Emergence of Repetitive Behavior in the C58/J Inbred Mouse Strain

The mouse is the leading organism for disease research. A rich resource of genetic variation occurs naturally in inbred and special strains owing to spontaneous mutations. However, one can also obtain...Full Text Available

2011-05-01

57

Progression of Neuronal and Synaptic Remodeling in the rd10 Mouse Model of Retinitis Pigmentosa

Mouse lines with behavioral phenotypes relevant to symptoms in neurodevelopmental disorders may provide models to test hypotheses about disease etiology and to evaluate potential treatments....Full Text Available

2010-03-17

58

Profound human/mouse differences in alpha-dystrobrevin isoforms: a novel syntrophin-binding site and promoter missing in mouse and rat

The Pde6b^rd10 (rd10) mouse has a moderate rate of photoreceptor degeneration and serves as a valuable model for human autosomal recessive retinitis pigmentosa...Full Text Available

2010-06-01

59

New strain of mouse hepatitis virus as the cause of lethal enteritis in infant mice.

BackgroundThe dystrophin glycoprotein complex is disrupted in Duchenne muscular dystrophy and many other neuromuscular diseases. The principal heterodimeric partner of dystrophin...Full Text Available

60

Genetically-engineered mouse models for pancreatic cancer: Advances and current limitations

A new strain of mouse hepatitis virus (MHV) was isolated from pooled gut suspensions from an epizootic of lethal enteritis in newborn mice. Negative-contrast electron microscopy showed an abundance...Full Text Available

1979-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

61

Establishment of trophectoderm and inner cell mass lineages in the mouse embryo

Recently, there has been significant progress in the development of genetically-engineered mouse (GEM) models. By introducing genetic alterations and/or signaling alterations of human pancreatic cancer...Full Text Available

2011-05-10

62

Differential expression of prostaglandin-H synthase isoenzymes in normal and activated keratinocytes in vivo and in vitro.

The first cell lineage specification in mouse embryo development is the formation of trophectoderm (TE) and inner cell mass (ICM) of the blastocyst. This article is to review and discuss the...Full Text Available

2009-11-01

63

Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV.

Normal mouse epidermis constitutively expresses prostaglandin-H synthase 1 (PGHS-1) but no PGHS-2. Acute inflammation and epidermal hyperplasia, (hyperplastic transformation), as evoked in adult mouse...Full Text Available

1995-07-01

64

Characterization of Mouse UDP-glucose Pyrosphosphatase, a Nudix Hydrolase encoded by the Nudt14 Gene

The cellular receptor for murine coronavirus mouse hepatitis virus (MHV)-A59 is a member of the carcinoembryonic antigen (CEA) family of glycoproteins in the immunoglobulin superfamily. We isolated...Full Text Available

1991-12-01

65

Cerebellar cell surface antigens of mouse brain.

Recombinant mouse UDP-glucose pyrophosphatase (UGPPase), encoded by the Nudt14 gene, was produced in Escherichia coli and purified close to homogeneity. The...Full Text Available

2009-12-25

66

Cell Polarity Regulator PARD6B Is Essential for Trophectoderm Formation in the Preimplantation Mouse Embryo1

Reaggregated cells from 6- to 8-day-old mouse cerebella have been used to raise antibodies in rabbits. The interaction of these antibodies with cerebellar cell surface components was assessed by cytotoxicity...Full Text Available

1975-10-01

67

Androgens and spermatogenesis: lessons from transgenic mouse models

In preimplantation mouse development, the first cell lineages to be established are the trophectoderm (TE) and inner cell mass. TE possesses epithelial features, including apical-basal cell polarity...Full Text Available

2010-09-01

68

Experimental and theoretical studies of nuclear generation of ozone and its photolysis into singlet delta oxygen

Transgenic mouse models have contributed considerably to our understanding of the cellular and molecular mechanisms by which androgens control spermatogenesis. Cell-selective ablation of the androgen...Full Text Available

2010-05-27

69

Investigation of genomic instability by assay of DNA fingerprint from the offspring of male mice exposed to chronic low-level #gamma#-radiation

A series of measurements of O_3 yield in nuclear induced O_2 and O_2-SF_6 discharges created by bombardment with energetic particles from the "1"0B(n,#alpha#)"7Li reaction are reported. Continuous irradiation at dose ratios of 10"1"5-10"1"7 eV.cm"-"3.s"-"1 and pulsed irradiation (approx.10 ms FWHM) at a peak dose rate of approx.10"2"0 eV.cm"-"3.s"-"1 were conducted. At the lower dose rates, SF_6 addition generally increased the ozone yield, which at the high dose rates, SF_6 addition decreased the observed ozone concentration. A numerical model was developed and applied to experimental conditions. The steady-state ozone concentration was found to be limited by the reaction O_3"- + O_3 #-># 2O_2 + O_2"-. A simplified analytical model of steady-state conditions was used to predict model sensitivity to various parameters. In addition to dose rate effects, pressure and temperature effect on ozone production were discussed. The present study was ...

70

Committed T lymphocyte stem cells of rats. Characterization by surface W3/13 antigen and radiosensitivity

By polymerase chain reaction with arbitrary primer (AP-PCR), the possibility of transmission of genome instability to somatic cells of the offspring (F_1 generation) from male parents of mice exposed to chronic low-dose #gamma#-radiation was studied. Male mice 15 days after exposure to 10-50 cGy were mated with unirradiated females. Biopsies were taken from tale tips of two month-old mice progeny for DNA separation. Primer in the AP-PCR was 20-mer oligonucleotide flanking the micro-satellite locus Atplb2 on chromosome 11 of the mouse. Comparative analysis of individual fingerprints of AP-PCR products on DNA-templates from the offspring of irradiated and unirradiated male mice revealed an increased variability of micro-satellite-associated sequences in the genome of the offspring of males exposed to 25 and 50 cGy. DNA-fingerprints of the offspring of male mice exposed to chronic irradiation doses 10 and 25 cGy. 15 days ...

2000-11-20

71

Biological Effects after Prenatal Irradiation

The existence of stem cells committed to the T lymphoid lineage was deduced from studying how rat T and B stem cells differ in their expression of membrane W3/13 antigen and in their susceptibility in vivo to gamma irradiation. Stem cell activity of rat bone marrow and fetal liver was measured in long-term radiation chimeras using B and T cell alloantigenic surface markers to identify the progeny of donor cells. Monoclonal mouse anti-rat thymocyte antibody W3/13 labeled approximately 40% of fetal liver cells and 60-70% of young rat bone marrow cells (40% brightly, 25% dimly). Bright, dim, and negative cells were separated on a fluorescence-activated cell sorter. All B and T lymphoid stem cells in fetal liver were W3/13 bright, as were B lymphoid stem cells in bone marrow. W3/13 dim bone marrow had over half the T cell repopulating activity of unseparated marrow but gave virtually no B cell repopulation. In further experiments, the ...

1981-01-01

72

Vacuum ultraviolet radiometry of xenon positive column discharges

A Task Group of the International Commission on Radiological Protection (ICRP) has finished a report Biological Effects after Prenatal Irradiation (Embryo and Fetus) which has been approved by the Main Commission and Will be Published. Some new important scientific data shall be discussed in this contribution. During the preimplantation period lethality of the mammalian embryo is the dominating radiation effect. However, in mouse strains with genetic predispositions it has been shown that also malformations can be caused. This effect is genetically determined and its mechanisms is different from the induction of malformations during major organogenesis. Radiation exposures during this prenatal period leads ato an increase of genomic instability of cells in the normal appearing fetuses. These radiation effects can be transmitted to the next generation. A renewed analysis of individuals with severe mental retardation after exposures during the ...

73

f 07821-6004-R0-00 RESEARCH PROGRAM ON HOLOGRAPHIC - NASA ...

In order to judge the potential fluorescent lamp applications of various low-pressure positive column discharges it is necessary to measure the absolute power emitted in the ultraviolet region of the spectrum. For rare-gas discharges the principle emission occurs in the vacuum ultraviolet so that it is difficult to measure the radiant emittance (power per unit area) of the resonance radiation by standard methods. Two independent techniques are discussed for measuring the radiant emittance of positive column discharges in the vacuum ultraviolet. These techniques are used to study xenon positive column discharges at the resonance wavelength of 147 nm. The first method relies on the measurement of the resonance level density by absorption techniques. The effective decay rate of the resonance level is then determined by the simulation of resonance radiation transport. These two quantities are combined to yield the radiant ...

1995-10-01

74

Test and Evaluation of Liquid Polymers for Use in Army ...

in a KDP crystal fed with red light from a Q-s_tched ruby laser. One reason for interest in holograms made with ultraviolet ...

75

Remote Sensor Systems for Unmanned Planetary Missions

... The addition of 0.5 pphr of fine thermal carbon black to the polymers gave good resistance to 500 hours of ultraviolet (UV) xposure in a Weather ...

1972-10-01

76

Photoconductive ultraviolet detectors based on ZnO films

instrument is shown in Figure 4-9 The incoming radiation is focused onto ...... An early rocket-borne ultraviolet spectrometer of the Ebert type by ...

77

British Library Electronic Table of Contents (United Kingdom)

Properties of photoconductive ultraviolet detectors fabricated on ZnO films were presented. Highly c-axis oriented ZnO films were grown on glass substrates by pulsed laser deposition. Ultraviolet photodetectors were fabricated based on metal-semiconductor-metal planar structures. The photoresponsivity and the quantum efficiency are much higher in the ultraviolet range than in the visible range, and the peak values are around 360nm. Photocurrent transients show that the detector has a large photocurrent with the peak value of 2.8mA, and a slow photoresponse with a rise time of 5min and a decay time of 7min. The response curve of the detector is fitted well with exponential curve. The large photocurrent should result from the both effects of the accumulation of conduction electrons and the d...

2006-01-01

78

Three novel mutations responsible for Cockayne syndrome group A

The Sorcerer II Global Ocean Sampling Expedition: Expanding theUniverse of Protein Families

Cockayne syndrome (CS) is a rare autosomal recessive disease, which shows diverse clinical symptoms such as photosensitivity, severe mental retardation and developmental defects. CS cells are hypersensitive to killing by ultraviolet (UV)-irradiation and defective in transcription-coupled repair. Two genetic complementation groups in CS (CS-A and CS-B) have been identified. We analyzed mutations of the CSA gene in 5 CS-A patients and identified 3 types of mutations. Four unrelated CS-A patients (CS2OS, CS2AW, Nps2 and CS2SE) had a deletion including exon 4, suggesting that there is a founder effect on the CSA mutation in Japanese CS-A patients. Patient CS2SE was a compound heterozygote for this deletion and an amino acid substitution at the 106th glutamine to proline (Q106P) in the WD-40 repeat motif of the CSA protein, which resulted in a defective nucleotide excision repair. Patient Mps1 had a large deletion in the upstream region including ...

2003-02-01

79

Exposure of Finnish population to solar UV radiation and consequent carcinogenic effects

Metagenomics projects based on shotgun sequencing of populations of micro-organisms yield insight into protein families. We used sequence similarity clustering to explore proteins with a comprehensive dataset consisting of sequences from available databases together with 6.12 million proteins predicted from an assembly of 7.7 million Global Ocean Sampling (GOS) sequences. The GOS dataset covers nearly all known prokaryotic protein families. A total of 3,995 medium- and large-sized clusters consisting of only GOS sequences are identified, out of which 1,700 have no detectable homology to known families. The GOS-only clusters contain a higher than expected proportion of sequences of viral origin, thus reflecting a poor sampling of viral diversity until now. Protein domain distributions in the GOS dataset and current protein databases show distinct biases. Several protein domains that were previously categorized as kingdom specific are shown to have GOS examples in other kingdoms. About ...

2006-03-23

80

An ultraviolet-inducible adenosine-adenosine cross-link reflects the catalytic structure of the Tetrahymena ribozyme

Depletion of stratospheric ozone increases irradiance of terrestrial ultraviolet (UV) radiation at short wavelengths, which may be harmful to the human health. To understand quantitatively the risks caused by increasing UV radiation to the Finnish population, the actual UV exposure of the population has to be assessed. It was shown that the snow reflection increases the UV exposure to the face and eyes particularly in the northern Finland. In 1993 exceptionally low ozone levels persisted up to the end of May, which resulted in a theoretical increase in the annual UV dose ranging from 8 % to 13 % in Finland. The maximal increase in the measured erythemally effective dose rate was 34 % on 23 April, when compared with the theoretical normal value. During this study exposure models have been developed. The models have been combined them with Green`s radiation transfer model to estimate annual facial UV doses received by different groups of Finnish ...

1996-12-31

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

81

Simultaneous ultraviolet spectrophotometric determination of nitrate and nitrite in water

When a shortened enzymatic version of the Tetrahymena self-splicing intervening sequence (IVS) RNA is placed under catalytic conditions and irradiated at 254 nm, a covalent cross-link forms with high efficiency. The position of the cross-link was mapped by using three independent methods: RNase H digestion, primer extension with reverse transcriptase, and partial hydrolysis of end-labeled RNA. The cross-link is chemically unusual in that it joins two adenosines, A57 and A95. Formation of this cross-link depends upon the identity and concentration of divalent cations present and upon heat-cool renaturation of the IVS in a manner that parallels conditions required for optimal catalytic activity. Furthermore, cross-linking requires the presence of sequences within the core structure, which is conserved among group I intervening sequences and necessary for catalytic activity. Together these correlations suggest that a common folded structure permits cross-linking and ...

1990-06-12

82

Electronic structure of the Ru(0001) surface

A rapid and accurate method for the direct simultaneous determination of nitrate and nitrite is proposed. The method is applied to the determination of nitrate and nitrite in rainwater and wastewater without preliminary separation. The determinations are performed by a CPA matrix method with ultraviolet spectrophotometric detection. The results obtained are in agreement with those obtained by conventional methods for the determination of nitrate and nitrite.

1991-02-01

83

Absolute absorption of ozone in the midinfrared

This paper deals with the electronic structure of ruthenium. Synchrotron radiation in the range from 15 to 45 eV and angle-resolved ultraviolet photoemission are used to map the energies of the electronic states. The Fermi surface of Ru is determined using angle-resolved ultraviolet photoemission spectroscopy. The experimental results are compared with calculated photoemission spectra obtained within the framework of the one-step model of photoemission. (author)

2000-03-13

84

Mechanoluminescence of g-irradiated salt

The absolute absorption of ozone in the midinfrared has been measured relative to 253.7-nm ultraviolet absorption to an accuracy of 1% using a Bruker Fourier transform spectrometer. These new results agree with previous measurements by diode laser measurements after the latter are corrected for more recent infrared calculations and ultraviolet cross sections. They also agree with a determination based on refractive index measurements in the infrared. 16 refs., 4 figs., 3 tabs.

1992-12-20

85

Irradiation effects on electronic functional materials

No abstract prepared.

2002-07-01

86

Irradiation effect of laser on salivary glands

No abstract prepared

1998-01-01

87

Selective absorption of ultraviolet laser energy by human atherosclerotic plaque treated with tetracycline

Short communication.

1995-04-01

88

Population kinetics studies in mouse jejunum exposed prenatally to gamma rays at different dose rates

Tetracycline is an antibiotic that absorbs ultraviolet light at 355 nm and preferentially binds to atherosclerotic plaque both in vitro and in vivo. Tetracycline-treated human cadaveric aorta was compared with untreated aorta using several techniques: absorptive spectrophotometry; and tissue uptake of radiolabeled tetracycline, which showed 4-fold greater uptake by atheroma than by normal vessel. In addition, intravenous tetracycline administered to patients undergoing vascular surgery demonstrated characteristic fluorescence in surgically excised diseased arteries. Because of tetracycline's unique properties, the authors exposed tetracycline-treated and untreated aorta to ultraviolet laser radiation at a wavelength of 355 nm. They found enhanced ablation of tetracycline-treated atheroma compared with untreated atheroma. The plaque ablation caused by ultraviolet laser radiation was twice as extensive in ...

1985-05-01

89

Pregnant Swiss albino mice of 18 days post conception were exposed to 0.80 Gy, 0.40 Gy and 0.20 Gy of gamma rays from a Cobalt-60 source at different dose rates (.0584 Gy/min and .00091 Gy/min). Post irradiation variations in the cell population of crypts and villus of jejunum were studied in the F_1-generation at 1 day, 3 day and 1,2,4,6 and 12 weeks of post-partum age. In all the exposure groups at 1 day post-partum age, crypts show a decrease in total cells, mitotic figures and goblet cells on one hand and an increase in PNNC on the other hand in comparison to coeval controls. At this interval a decrease in the number of total cells as well as goblet cells/villus column was also noticeable. Dead cells which were prominently seen in crypts were totally absent in villi. The first signs of recovery can be observed on day 3 p.p. when total cell population, mitotic activity and goblet cells of crypt registered an increase while percentage of PNNC showed a fall. ...

2001-02-20

90

Wildlife

Visualization of Tumor Angiogenesis Using MR Imaging Contrast Agent Gd-DTPA-anti-VEGF Receptor 2 Antibody Conjugate in a Mouse Tumor Model.

Deer Elk Bighorn Sheep American Pronghorn Moose Deer Mouse Carnivores Bobcat American Badger River Otter Red Fox Long-Tailed Weasel Coyote Grizzly Bear Mountain Lion Amphibians...

2011-10-15

91

Therapeutic cloning in the mouse

Full Text Available

2010-07-01

92

Strain-dependent variation in collateral circulatory function in mouse hindlimb

Nuclear transfer technology can be applied to produce autologous differentiated cells for therapeutic purposes, a concept termed therapeutic cloning. Countless articles have been published on the ethics...Full Text Available

2003-09-30

93

Roles of ER, Src-1, and CBP Phosphorylation in Estrogen ...

The extent (density and diameter) of the native (preexisting) collateral circulation in healthy tissues and the capacity of collaterals to enlarge/remodel in obstructive arterial disease are important...Full Text Available

2010-08-01

94

Production and Characterization of Monoclonal Antibodies to Mouse Germ Cells

... from a mouse carcinogen-induced mammary gland tumor model indicated that it is overexpressed in 12 out of 13 tumors ...

1998-06-01

95

British Library Electronic Table of Contents (United Kingdom)

In mammals, primordial germ cells (PGCs) are generated in the extra-embryonic epiblast, and thereafter migrate into the developing gonads. Following the development of the gonads to the testes or ovaries, germ cells mature into sperms or eggs. In the present study, we report production and characterization of monoclonal antibodies (MAb) that recognize PGCs. Extracts from E12.5 mouse embryonic gonads were immunized as an antigen, and hybridomas were generated using the rat medial iliac lymph node method. The hybridoma supernatants were screened by immunohistochemical analyses of E12.5 mouse embryonic sections. The antibody, referred to herein as MAb 5B5, provided strong signals on PGCs. Moreover, immunofluorescence analyses using a variety of the tissue sections of mouse embryos revealed th...

2010-01-01

96

Molecular cloning and analysis of lymphokines. Volume 13

These proceedings collect papers on the subject of lymphokines. Topics include: DNA-cloning of mouse and human lymphokine genes, inteferons, interleukins, gene expression, tumor necrosis factors, and recombinant DNA.

1987-01-01

97

Guidance for Industry

Early social enrichment shapes adult brain function and increases resilience to depression-like responses in the mouse

... accidentally released from a Soviet military laboratory (Meselson ... Robert Koch and Louis Pasteur worked to introduce ... species (eg, rat, mouse, dog, monkey) for ...

98

Epidemiological survey of the effects of low level radiation dose: a comparative assessment

... brain take place. This highly plastic period offers the possibility for

2008-10-01

99

Contact lens disinfection by ultraviolet light

This volume presents the collations tables of a six volume comparative epidemiological survey of the effects of low level radiation dose. Data are collated for the effects observed in the following irradiated groups:- Preconception irradiation, intra-uterine irradiation, childhood irradiation, adult irradiation. (UK).

1993-10-01

100

A proposed linac cavity rf drive system for the Los Alamos extreme ultraviolet free-electron laser

A 253.7-nm ultraviolet light with an intensity of 1,100 microW/cm2 was tested for its germicidal activity against contact lenses and storage solutions contaminated with various corneal pathogens. The exposure time necessary to reduce a concentration of organisms from 10(6)/ml to less than 10/ml was 30 seconds for Staphylococcus aureus, 60 seconds for Pseudomonas aeruginosa, and 84 seconds for Candida albicans. The time necessary to sterilize a suspension of 10(4)/ml Acanthamoeba polyphaga was less than three minutes with this technique. Four brands of soft contact lenses were exposed to ultraviolet light for over eight hours without changing their appearance, comfort, or refraction.

1989-12-15

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

101

Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens.

Since 1979, scientists and engineers at the Los Alamos National Laboratory have designed, constructed, and operated a radio-frequency (RF) linac free-electron laser (FEL) at wavelengths from 9 to 45 /mu/m. Coupled with success of other research centers investigating wavelengths from the visible to far-infrared, Los Alamos is now proposing a vacuum-ultraviolet and soft x-ray (referred to henceforth as extreme ultraviolet, (XUV)) FEL oscillator/Self-Amplified Spontaneous Emission amplifier with beam energies ranging from 100 MeV to 1 GeV. This paper will focus on the first milestone of the proposed Los Alamos XUV project, i.e., a 250-MeV linac with approximately 50 mA of average current, producing photons with wavelengths below 1000 /angstrom/. 3 refs., 3 figs.

1989-01-01

102

Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels

Two monoclonal antibodies, TAL-1B5 and TAL-3C3, specific for human Ia alpha-chain subunits have been produced by fusing P3/NSI/1-Ag4-1 mouse myeloma cells with spleen cells from a BALB/c mouse immunized...Full Text Available

1983-12-01

103

Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters: Possible reaction of cadmium with the zinc finger domain of Sp1

Genome sequences are essential tools for comparative and mutational analyses. Here we present the short read sequence of mouse chromosome 17 from the Mus musculus domesticus derived...Full Text Available

2009-01-01

104

C57BL/6J, DBA/2J, and DBA/2J.Gpnmb⁺ mice have different visual signal processing in the inner retina

Cadmium (Cd) exposure causes glucosuria (glucose in the urine). Previously, it was shown that Cd exposure of primary cultures of mouse kidney cells (PMKC) decreased mRNA levels of the glucose...Full Text Available

2010-05-01

105

Smooth muscle myosin heavy chain locus (MYH11) maps to 16p13. 13-p13. 12 and establishes a new region of conserved synteny between human 16p and mouse 16

PurposeTo characterize differences in retinal ganglion cell (RGC) function in mouse strains relevant to disease models. C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse...Full Text Available

106

S1 nuclease analysis of #alpha#-globin gene expression in preleukemic patients with acquired hemoglobin H disease after transfer to mouse erythroleukemia cells

The human smooth muscle myosin heavy chain locus (MYH11) was mapped by fluorescence in situ hybridization to the middle of the p arm of chromosome 16 using a genomic cosmid clone containing coding sequences of the gene as probe. Probe from coding sequence, when applied to Southern blots of a panel of hybrids containing different portions of human chromosome 16, localized the gene to 16p13.13-13.12. Coding sequence PCR primers, when used on the DNA from a CHO-mouse hybrid clone mapping panel informative for mouse chromosomes, showed that the gene was located on mouse chromosome 16. These results correct a recent assignment of MYH11 from 16q12.2 to the region of the 16p-arm inversion breakpoint seen in acute myelomonocytic leukemia (AMML) M4Eo and demonstrate that the conflicting data do not result from the presence of additional MYH genes on the q arm of the chromosome. Also, a new region of conserved synteny between human ...

1993-10-01

107

UV renormalons in QCD and their phenomenological implications

The loss of #alpha#-globin gene transcriptional activity rarely occurs as an acquired abnormality during the evolution of myeloproliferative disease or preleukemia. To test whether the mutation responsible for the loss of #alpha#-globin gene expression (hemoglobin H disease) in these patients is linked with the #alpha#-globin genes on chromosome 16, the authors transferred chromosome 16 from preleukemic patients with acquired hemoglobin H disease to mouse erythroleukemia cells and measured the transcriptional activity of the human #alpha#-globin genes. After transfer to mouse erythroleukemia cells, the expression of human #alpha#-globin genes from the peripheral blood or marrow cells of preleukemic patients with acquired hemoglobin H disease was similar to that of human #alpha#-globin genes transferred to mouse erythroleukemia cells from normal donors. These data showed that factor(s) in the mouse ...

108

The Goddard Library - Goddard Projects Directory - NASA

I report on some recent work done in collaboration with E. de Rafael on the connection between ultraviolet renormalons in QCD and Nambu-Jona-Lasinio-like Lagrangians as its effective description at low energies. (orig.)

1998-05-01

109

Sunbed use during adolescence and early adulthood is associated with increased risk of early-onset melanoma

Oct 2, 2007 ... The Payload combines some of the most sensitive particle sensors .... provide state-of-the-art measurements of incoming x-ray, ultraviolet, .... It will be launched into a low-Earth orbit on a Delta 7320 rocket in September 2004. ...

110

Simultaneous Reactivation of Ultraviolet Damage in Xanthium Leaves ¹

Sunbed use is associated with increased risk of melanoma. Younger people might be more susceptible to the carcinogenic effects of ultraviolet radiation. We investigated the association between...Full Text Available

2011-05-01

111

Simulation study of chiral two dimensional ultraviolet (2DUV) spectroscopy of the protein backbone

Experiments on Xanthium leaf discs were carried out to determine whether concomitant photoreactivation could be detected and if so, to compare its effects with photoreactivation due...Full Text Available

1969-12-01

112

Photoelectron spectroscopy of carbonyls: benzoic acid and its derivatives

Amide n –π^* and π-π^* excitations around 200 nm are prominent spectroscopic...Full Text Available

2010-06-09

113

Photoconductive ultraviolet detectors based on ZnO films

The ultraviolet photoelectron spectra of benzoic acid and 20 of its derivatives are presented. The low-energy regions of these spectra are deconvoluted and assigned using chemical substitution effects. 5 figures, 3 tables.

1981-01-01

114

Photoconductive ultraviolet detectors based on ZnO films

Properties of photoconductive ultraviolet detectors fabricated on ZnO films were presented. Highly c-axis oriented ZnO films were grown on glass substrates by pulsed laser deposition. Ultraviolet photodetectors were fabricated based on metal-semiconductor-metal planar structures. The photoresponsivity and the quantum efficiency are much higher in the ultraviolet range than in the visible range, and the peak values are around 360 nm. Photocurrent transients show that the detector has a large photocurrent with the peak value of 2.8 mA, and a slow photoresponse with a rise time of 5 min and a decay time of 7 min. The response curve of the detector is fitted well with exponential curve. The large photocurrent should result from the both effects of the accumulation of conduction electrons and the decrease of the barrier height between crystallites. The relaxation time constant {tau} obtained from the curve fitting represents the ...

2006-12-15

115

Lack of adequate sun protection for children with oculocutaneous albinism in South Africa

Properties of photoconductive ultraviolet detectors fabricated on ZnO films were presented. Highly c-axis oriented ZnO films were grown on glass substrates by pulsed laser deposition. Ultraviolet photodetectors were fabricated based on metal-semiconductor-metal planar structures. The photoresponsivity and the quantum efficiency are much higher in the ultraviolet range than in the visible range, and the peak values are around 360 nm. Photocurrent transients show that the detector has a large photocurrent with the peak value of 2.8 mA, and a slow photoresponse with a rise time of 5 min and a decay time of 7 min. The response curve of the detector is fitted well with exponential curve. The large photocurrent should result from the both effects of the accumulation of conduction electrons and the decrease of the barrier height between crystallites. The relaxation time constant #tau# obtained from the curve fitting represents the ...

2006-12-15

116

In vitro and in vivo estrogenicity of UV screens.

BackgroundChildhood is a high risk time for ultraviolet induced skin damage as this age group has more time and opportunity to be outdoors in the sun. Children in Africa with the...Full Text Available

117

Chemoprevention of Nonmelanoma Skin Cancer With Celecoxib: A Randomized, Double-Blind, Placebo-Controlled Trial

Ultraviolet (UV) screens are increasingly used as a result of growing concern about UV radiation and skin cancer; they are also added to cosmetics and other products for light stability. Recent data...Full Text Available

2001-03-01

118

A rational vision of stratospheric ozone

BackgroundPreclinical studies indicate that the enzyme cyclooxygenase 2 plays an important role in ultraviolet-induced skin cancers. We evaluated the efficacy and safety of celecoxib,...Full Text Available

2010-12-15

119

Radiation 2006. In association with the Polymer Division, Royal Australian Chemical Institute. Incorporating the 21st AINSE Radiation Chemistry Conference and the 18th Radiation Biology Conference, conference handbook

This work deals with a rational vision of stratospheric ozone including the threats on ozone layer, the verifications and the fears. After a recalling on the ozone layer history, the authors treats the question of the ultraviolets particularly the beneficial effects. Then an explanation of the ozone layer decrease is given. (O.L.). 29 refs., 6 figs.

1995-03-01

120

Synthesis and antimicrobial effects of colloidal silver nanoparticles in chitosan by?-irradiation

Full text: An adaptive response is a decreased biological effect induced by a priming radiation dose given prior to a challenge dose. Adaptive responses contradict the linear-nothreshold model of risk estimation. The pKZ1 mouse chromosomal inversion assay is an extremely sensitive assay for studying the mutagenic effect of low dose radiation. A non-linear dose response for chromosomal inversion has been observed in pKZ1 spleen and prostate after a single whole body irradiation with doses between 1?Gy and 10mGy. Doses between 5-10?Gy resulted in an induction in inversions and doses between 1-10mGy resulted in a reduction below endogenous inversion frequency. These results suggest that doses in the 1-10 mGy range cause host responses which overcompensate by not only preventing inversions that would normally occur as a result of the low doses of radiation but also by preventing some of the endogenous inversions that would have occurred in the ...

2006-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

121

Studies on Polyacrylonitrile (3) Irradiation of Polyacrylonitrile

Not Available

2010-04-01

122

Recovery of Tc by annealing of irradiated A-15 compounds

Full Text Available

1967-06-01

123

Recoil Effects of Neutron-Irradiated Metal Permanganates

Not Available

1978-03-01

124

Production of sup 203 Pb by proton irradiation of Bi

Full Text Available

1988-06-01

125

Preparation of colloidal silver nanoparticles in poly(N-vinylpyrrolidone) by ?-irradiation

Short note.

1991-01-01

126

Microorganisms elimination in antiquity paper by gamma irradiation

Not Available

2008-09-01

127

Influence of irradiation on thermally stimulated current in PEEK

No abstract prepared.

2002-07-01

128

Detection of Gamma-Irradiated Spices by ESR Spectroscopy

No abstract prepared

1998-01-01

129

14 MeV neutron irradiation effects on window materials

Full Text Available

2001-04-01

130

Ionizing radiation is a potent inducer of mitotic recombination in mouse embryonic stem cells

No abstract prepared

1998-01-01

131

British Library Electronic Table of Contents (United Kingdom)

Maintenance of genomic integrity in embryonic cells is pivotal to proper embryogenesis, organogenesis and to the continuity of species. Cultured mouse embryonic stem cells (mESCs), a model for early embryonic cells, differ from cultured somatic cells in their capacity to remodel chromatin, in their repertoire of DNA repair enzymes, and in the regulation of cell cycle checkpoints. Using 129XC3HF1 mESCs heterozygous for Aprt, we characterized loss of Aprt heterozygosity after exposure to ionizing radiation. We report here that the frequency of loss of heterozygosity mutants in mESCs can be induced several hundred-fold by exposure to 5-10Gy of X-rays. This induction is 50-100-fold higher than the induction reported for mouse adult or embryonic fibroblasts. The primary mechanism underlying the...

2011-01-01

132

Effect of some chemicals on the radiation-induced lipid peroxidation

Computational mouse atlases and their application to automatic assessment of craniofacial dysmorphology caused by the Crouzon mutation Fgfr2C342Y

The effect of exposure to gamma rays on LPO contents in liver, spleen and kidney of mice and the anti-lipid-peroxidation of preparations of chinonin, tannic acid and squalene were reported. All these preparations were given by intragastric perfusion. For LPO, a modified method of TBA spectrophotometry was used for determination. The results show that LPO contents in tissues increased 72 h after whole-body exposure of mice to gamma rays, that in range of 0-4 Gy, there was a linear relationship between radiation doses and LPO contents, and that all three preparations were effective in reduction of the LPO content in liver, spleen and kidney of mice, with chinonin (at dose of 0.35 mg/mouse#centre dot#day) being more effective than tannic acid (at dose of 15 mg/mouse#centre dot#day) and squalene (at dose of 0.6 mg/mouse#centre dot#day).

133

British Library Electronic Table of Contents (United Kingdom)

Abstract Crouzon syndrome is characterized by premature fusion of sutures and synchondroses. Recently, the first mouse model of the syndrome was generated, having the mutation Cys342Tyr in Fgfr2c, equivalent to the most common human Crouzon/Pfeiffer syndrome mutation. In this study, a set of micro-computed tomography (CT) scannings of the skulls of wild-type mice and Crouzon mice were analysed with respect to the dysmorphology caused by Crouzon syndrome. A computational craniofacial atlas was built automatically from the set of wild-type mouse micro-CT volumes using (1) affine and (2) non-rigid image registration. Subsequently, the atlas was deformed to match each subject from the two groups of mice. The accuracy of these registrations was measured by a comparison of manually placed landma...

2007-01-01

134

Structure of Irradiated Materials

International Science & Technology Center (ISTC)

Fundamental Research of Materials Structure and Properties Changes Resulted from Irradiation by Means of Complex of Modern Physical Methods

135

Isolation of carrier-free tantalum radioisotopes from proton-irradiated hafnium

Intercomparison of irradiance measurements based on WRR and ETL irradiance scales

... carrier-free isotopes hafnium compounds irradiation protons solvent extraction

136

Wild-derived mouse stocks: an underappreciated tool for aging research

We report the corrected intercomparison of the World Radiometer Reference (WRR) irradiance scale and the Electrotechnical Laboratory (ETL) spectral irradiance scale. In addition, we confirm the intercomparison precision using the test facility where the irradiance of ETL 500 W standard lamp can be measured directly with the cavity radiometer. The results showed that the irradiance based on the WRR scale was 0.5-0.7% lower than the one based on the ETL scale

1997-10-14

137

Transposon-based screens for cancer gene discovery in mouse models

Virtually all biomedical research makes use of a relatively small pool of laboratory-adapted, inbred, isogenic stocks of mice. Although the advantages of these models are many, there are a number of...Full Text Available

2008-09-01

138

Topical Application of 5-Aminolevulinic Acid Hexyl Ester and 5-Aminolevulinic Acid to Normal Nude Mouse Skin: ...

Significant emphasis has recently been placed on the characterization of the human cancer genome. This effort has been assisted by the development of new DNA sequencing technologies that allow...Full Text Available

2010-08-01

139

The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model

... J. W. and R. A. de Zeeuw. 1990. Transdermal drug delivery: efficacy and potential applications of the penetration enhancer ... ...

140

Temporal and Tissue-Specific Patterns of Pon3 Expression in Mouse: In situ Hybridization Analysis

Dominant mutations in sarcomere protein genes cause hypertrophic cardiomyopathy, an inherited human disorder with increased ventricular wall thickness, myocyte hypertrophy, and disarray. To understand...Full Text Available

2002-04-15

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141

Targeted Deletion of Somatotroph Insulin-Like Growth Factor-I Signaling in a Cell-Specific Knockout Mouse Model

PON3 is a member of the paraoxonase gene family that includes PON1 and PON2. For example, PON3 and PON1 share...Full Text Available

2010-01-01

142

TLD assessment of mouse dosimetry during microCT imaging

The role of IGF-I in the negative regulation of GH expression and release is demonstrated by in vitro and in vivo models; however, the targets and mechanisms of IGF-I...Full Text Available

2010-05-01

143

Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection

Advances in laboratory animal imaging have provided new resources for noninvasive biomedical research. Among these technologies is microcomputed tomography (microCT) which is widely used to obtain high...Full Text Available

2008-09-01

144

Sodium/Calcium Exchangers Selectively Regulate Calcium Signaling in Mouse Taste Receptor Cells

BackgroundXenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study,...Full Text Available

145

Simple Behavioral Assessment of Mouse Olfaction

Taste cells use multiple signaling mechanisms to generate appropriate cellular responses to discrete taste stimuli. Some taste stimuli activate G protein coupled receptors (GPCRs) that cause calcium...Full Text Available

2010-07-01

146

Short-term regulation of muscarinic acetylcholine receptors: An assessment utilizing mouse brain and mouse neuroblastoma cells

This unit presents two basic protocols that offer rapid assessments of anosmia (the absence of a sense of smell) in mice. The buried food test is used to check for the ability to smell volatile...Full Text Available

2009-07-01

147

Sequential Molecular and Cellular Events during Neoplastic Progression: A Mouse Syngeneic Ovarian Cancer Model1

The effects of muscarinic agonists and diisopropylfluorophosphate (DFP) on muscarinic receptor density and muscarinic receptor-mediated responses was assessed in mouse brain and mouse neuroblastoma cells (clone N1E-115). Utilizing the antagonist ({sup 3}H)quinuclidinyl benzilate (({sup 3}H)QNB), there was no difference in the maximal binding capacity (B{sub max}) or equilibrium dissociation constant (K{sub d}) between untreated and 24 hour DFP-treated mice. However, one administration of DFP produced a 24% and 33% decrease in B{sub max} measured by ({sup 3}H)N-methylscopolamine (({sup 3}H)NMS) after 18 and 24 hours which was rapidly reversible within 36 hours after DFP treatment. The loss of ({sup 3}H)NMS binding sites following acute DFP treatment was not accompanied by a change in a particular muscarinic receptor binding conformation. Furthermore, the magnitude of muscarinic receptor-mediated phosphoinositide hydrolysis was unchanged ...

1988-01-01

148

SELF-RENEWAL AND DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS AS MEASURED BY Oct4 GENE EXPRESSION: EFFECTS OF LIF, ...

AbstractStudies performed to identify early events of ovarian cancer and to establish molecular markers to support early detection and development of chemopreventive regimens have been...Full Text Available

2005-10-01

149

Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2)

... from Dr. Austin Smith of the Institute for Stem Cell Research, University of Edinburgh) was modified from the CGR8 ... to thank Dr. Austin Smith, the Institute for Stem Cell Research, University of Edinbu...

150

QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains

Genomic disorders are conditions that result from DNA rearrangements, such as deletions or duplications. The identification of the dosage-sensitive gene(s) within the rearranged genomic interval is...Full Text Available

2006-11-01

151

Purification and translation of murine mammary tumor virus mRNA's.

The activity of mice in their home cage is influenced greatly by the cycle of light and dark. In addition, home-cage activity shows remarkable time-dependent changes that result in a prominent temporal...Full Text Available

2010-10-01

152

Pulmonary toxicity and carcinogenicity of trichloroethylene: species differences and modes of action.

We have studied the functions of the intracellular RNAs of mouse mammary tumor virus (MMTV) by purification and translation in vitro. Two major size classes of MMTV RNA, 35S and 24S RNA, were isolated...Full Text Available

1981-07-01

153

Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells

Trichloroethylene (TCE) is both acutely toxic and carcinogenic to the mouse lung following exposure by inhalation. In contrast, it is not carcinogenic in the rat lung and is markedly less toxic following...Full Text Available

2000-05-01

154

Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis

Recent reports suggested that phosphatase of regenerating liver (PRL)-3 might be involved in colorectal carcinoma metastasis with an unknown mechanism. Here we demonstrated that PRL-3 expression was...Full Text Available

2004-06-01

155

Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor survival. The identification of therapeutic targets is essential to improving outcomes. Previous studies found that expression...Full Text Available

2011-03-31

156

OLFACTORY CUES ARE SUFFICIENT TO ELICIT SOCIAL APPROACH BEHAVIORS BUT NOT SOCIAL TRANSMISSION OF FOOD PREFERENCE IN C57BL/6J MICE

BackgroundSeasonal influenza A infection affects a significant cohort of the global population annually, resulting in considerable morbidity and mortality. Therapeutic strategies...Full Text Available

2011-05-01

157

Novel Pathologic Findings Associated with Urinary Retention in a Mouse Model of Mucopolysaccharidosis Type IIIB

Mouse models for the study of autistic-like behaviors are increasingly needed to test hypotheses about the causes of autism, and to evaluate potential treatments. Both the automated 3-chambered...Full Text Available

2008-11-21

158

Multivariate analyses reveal common and drug specific genetic influences on responses to four drugs of abuse

Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome type B) is a metabolic disorder with devastating clinical characteristics starting in early childhood and leading to premature death. A...Full Text Available

2009-04-01

159

Multiple integration sites for Moloney murine leukemia virus in productively infected mouse fibroblasts.

Vulnerability to abused drugs is influenced by multiple genes unique to each drug as well as to risk genes for polydrug abuse. If several inbred mouse strains respond to different drugs similarly,...Full Text Available

2008-11-01

160

Multiple Genes on Chromosome 7 Regulate Dopaminergic Amacrine Cell Number in the Mouse Retina

The integration sites for viral DNA in cells infected with Moloney murine leukemia virus (M-MuLV) were studied by restriction endonuclease cleavage of cellular DNA followed by electrophoresis in agarose...Full Text Available

1979-06-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

Mouse model predicts effects of smoking and varenicline on event-related potentials in humans

PurposeThe size of neuronal populations is modulated by gene variants that influence cell production and survival, in turn influencing neuronal connectivity, function,...Full Text Available

2009-05-01

162

Monitoring of Tumor Promotion and Progression in a Mouse Model of Inflammation-Induced Colon Cancer with Magnetic Resonance Colonography1

Background:Nicotine alters auditory event-related potentials (ERPs) in rodents and humans and is an effective treatment for smoking cessation. Less is known about the effects of...Full Text Available

2010-06-01

163

Mesenchymal cell re-modeling during mouse secondary palate re-orientation

Early detection of precancerous tissue has significantly improved survival of most cancers including colorectal cancer (CRC). Animal models designed to study the early stages of cancer are valuable...Full Text Available

2009-03-01

164

Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK

The formation of mammalian secondary palate requires a series of developmental events such as growth, elevation and fusion. Despite recent advances in the field of palate development, the process...Full Text Available

2010-07-01

165

Macrophage-directed immunotherapy as adjuvant to photodynamic therapy of cancer.

BackgroundMacrophages (MΦs) utilize macropinocytosis to integrate immune and metabolic signals in order to initiate an effective immune response. Diabetes is characterized...Full Text Available

166

Longitudinal assessment of lung cancer progression in the mouse using in vivo micro-CT imaging

The effect of Photofrin-based photodynamic therapy (PDT) and adjuvant treatment with serum vitamin D3-binding protein-derived macrophage-activating factor (DBPMAF) was examined using a mouse SCCVII...Full Text Available

1997-01-01

167

Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2

Purpose: Small animal micro-CT imaging is being used increasingly in preclinical biomedical research to provide phenotypic descriptions of genomic models. Most of this imaging is coincident...Full Text Available

2010-09-01

168

Lack of LDL Receptor Enhances Amyloid Deposition and Decreases Glial Response in an Alzheimer's Disease Mouse Model

In addition to its role in megakaryocyte production, signaling initiated by thrombopoietin (TPO) activation of its receptor, myeloproliferative leukemia virus protooncogene (c-Mpl, or Mpl), controls...Full Text Available

2008-08-01

169

Influence of murine leukemia proviral integrations on development of N-methyl-N-nitrosourea-induced thymic lymphomas in AKR mice.

BackgroundApolipoprotein E (ApoE), a cholesterol carrier associated with atherosclerosis, is a major risk factor for Alzheimer's disease (AD). The low-density lipoprotein receptor...Full Text Available

170

Increases in mouse uterine heat shock protein levels are a sensitive and specific response to uterotrophic agents.

The AKR mouse strain is characterized by a high incidence of spontaneous thymic lymphoma that appears in older animals (greater than 6 months of age) and is associated with novel provirus integrations...Full Text Available

1991-11-01

171

Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance

There is increasing consensus that the uterotrophic estrogenicity assay should be coupled with other morphometric or molecular end points that might enhance its sensitivity. We have previously shown...Full Text Available

2002-12-01

172

In Vivo RNAi Screening Identifies Regulators of Actin Dynamics as Key Determinants of Lymphoma Progression

Insulin resistance in skeletal muscle is a key phenotype associated with type 2 diabetes (T2D) for which the molecular mediators remain unclear. We therefore conducted an expression analysis of human...Full Text Available

2011-03-01

173

Identification of tumor-initiating cells in a p53-null mouse model of breast cancer.

Mouse models have dramatically improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic...Full Text Available

2009-10-01

174

Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb development

Using a syngeneic p53-null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified, by limiting dilution transplantation and in vitro mammosphere assay, a Lin(-)CD29(H)CD24(H) subpopulation of tumor-initiating cells. Upon subsequent transplantation, this subpopulation generated heterogeneous tumors that displayed properties similar to the primary tumor. Analysis of biomarkers suggests the Lin(-)CD29(H)CD24(H) subpopulation may have arisen from a bipotent mammary progenitor. Differentially expressed genes in the Lin(-)CD29(H)CD24(H) mouse mammary gland tumor-initiating cell population include those involved in DNA damage response and repair, as well as genes involved in epigenetic regulation previously shown to be critical for stem cell self-renewal. These studies provide in vitro and in vivo data that support the cancer stem cell (CSC) hypothesis. Furthermore, this p53-null mouse mammary ...

2008-06-15

175

BackgroundThe zinc-finger transcription factor GLI3 is an important mediator of Sonic hedgehog signaling and crucial for patterning of many aspects of the vertebrate body plan. In...Full Text Available

176

Functional and Behavioral Restoration of Vision by Gene Therapy in the Guanylate Cyclase-1 (GC1) Knockout Mouse

BackgroundDue to the high morbidity and mortality of fulminant hepatitis, early diagnosis followed by early effective treatment is the key for prognosis improvement. So far, little...Full Text Available

177

Functional Interactions between Retinoblastoma and c-MYC in a Mouse Model of Hepatocellular Carcinoma

BackgroundRecessive mutations in guanylate cyclase-1 (Gucy2d) are associated with severe, early onset Leber congenital amaurosis-1(LCA1). Gucy2d...Full Text Available

178

Fibroblast cell population kinetics in the mouse molar periodontal ligament and tooth eruption.

Inactivation of the RB tumor suppressor and activation of the MYC family of oncogenes are frequent events in a large spectrum of human cancers. Loss of RB function and MYC activation are thought to...Full Text Available

179

Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung Adenocarcinoma

Fibroblast cell population kinetics in the developing molar periodontal ligament was investigated in 10, 12, 16 and 20 days old mice by autoradiography after the administration of [3H]thymidine. Labelled...Full Text Available

1981-09-01

180

Evidence for proteolytic cleavage of brevican by the ADAMTSs in the dentate gyrus after excitotoxic lesion of the mouse entorhinal cortex

BackgroundNon-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize....Full Text Available

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181

Effect of misonidazole pretreatment on nitrogen mustard-induced DNA cross-linking in mouse tissues in vivo.

BackgroundBrevican is a member of the lectican family of aggregating extracellular matrix (ECM) proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in...Full Text Available

182

Drosophila neuroblasts retain the daughter centrosome

In the present study we have used the alkaline elution technique to study the effect of misonidazole (MISO) on the initial amount of DNA cross-linking in various normal and neoplastic tissues of C3H...Full Text Available

1984-12-01

183

Diurnal Variations of Mouse Plasma and Hepatic Bile Acid Concentrations as well as Expression of Biosynthetic Enzymes and Transporters

During asymmetric mitosis, both in male Drosophila germline stem cells and in mouse embryo neural progenitors, the mother centrosome is retained by the self-renewed cell; hence suggesting...Full Text Available

184

Dissecting the Genetic Components of Adaptation of Escherichia coli to the Mouse Gut

BackgroundDiurnal fluctuation of bile acid (BA) concentrations in the enterohepatic system of mammals has been known for a long time. Recently, BAs have been recognized as signaling...Full Text Available

185

Disruption of Bidirectional Oocyte-Cumulus Paracrine Signaling During In Vitro Maturation Reduces Subsequent Mouse Oocyte Developmental Competence1

While pleiotropic adaptive mutations are thought to be central for evolution, little is known on the downstream molecular effects allowing adaptation to complex ecologically relevant environments. Here...Full Text Available

2008-01-01

186

Differing in vitro Survival Dependency of Mouse and Rat NG2⁺ Oligodendroglial Progenitor Cells

Oocyte-cumulus cell bidirectional communication is essential for normal development of the oocyte and cumulus cells (CCs) within the follicle. We showed recently that addition of recombinant growth...Full Text Available

2009-05-01

187

Dietary Ammonium Chloride for the Acidification of Mouse Urine

NG2 chondroitin sulfate proteoglycan is a surface marker of oligodendroglial progenitor cells (OPCs) in various species. In contrast to well-studied rat OPCs, however, we found that purified...Full Text Available

2010-04-01

188

Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice

A novel therapeutic compound was found to induce bladder tumors in male rats. Given the location of the tumors and the increased amounts of calcium- and magnesium-containing solids found in the urine...Full Text Available

2009-03-01

189

Development of a novel mouse tk{sup +/-} embryonic stem cell line for use in mutagenicity studies

Uncoupling protein 2 (UCP2) maps to a region on distal mouse chromosome 7 that has been linked to the phenotypes of obesity and type II diabetes. We recently reported that UCP2 expression is increased...Full Text Available

1998-03-31

190

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse

A tk{sup +/-} mouse embryonic stem (ES) cell line, designated 1G2, has been created in which one allele of the thymidine kinase (tk) gene was inactivated by targeted homologous recombination. This line is an analog of the mouse lymphoma tk{sup +/-} L5178Y cell line, which is used widely to assess the mutagenicity of chemical agents. Treatment of 1G2 cells with the alkylating agent N-ethyl-N-nitrosourea (ENU) resulted in a dose-related increase in tribluorothymidine-resistant colonies. Mutant frequencies of 152 and 296 per 10{sup 6} cells were determined for 0.1 and 0.3 mg/ml doses of ENU, compared with a spontaneous mutant frequency of 15 per 10{sup 6} cells. The data indicate that tk{sup +/-} 1G2 ES cells may be useful for the creation of a transgenic mouse model for assessing in vivo mutation using an endogenous autosomal gene. 45 refs., 2 figs., 1 tab.

1996-12-31

191

De Novo Induction of Genetically Engineered Brain Tumors In Mice Using Plasmid DNA

OBJECTIVEPrevious studies showed that genetic deletion or pharmacological blockade of the receptor for advanced glycation end products (RAGE) prevents the early structural changes...Full Text Available

2010-08-01

192

Controlled Somatic and Germline Copy Number Variation in the Mouse Model

Spontaneous mouse models of cancer show promise to more accurately recapitulate human disease and predict clinical efficacy. Transgenic mice or viral vectors have been required to generate spontaneous...Full Text Available

2009-01-15

193

Conservation of spermatogonial stem cell self-renewal signaling between mouse and rat

Changes in the number of chromosomes, but also variations in the copy number of chromosomal regions have been described in various pathological conditions, such as cancer and aneuploidy, but also in...Full Text Available

2010-09-01

194

Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes

Self-renewal of spermatogonial stem cells (SSCs) is the foundation for maintenance of spermatogenesis throughout life in males and for continuation of a species. The molecular mechanism underlying stem...Full Text Available

2005-10-04

195

Comparison of geographical strains of Schistosoma mansoni in the mouse*

BackgroundMammalian antimicrobial peptides (AMPs) are effectors of the innate immune response. A multitude of signals coming from pathways of mammalian pathogen/pattern recognition...Full Text Available

196

Cloning and mapping of the mouse {alpha}7-neuronal nicotinic acetylcholine receptor

Mice were killed 7, 11, 19, and 27 weeks after infection with strains of Schistosoma mansoni from Puerto Rico, Brazil, St Lucia, and Tanzania. The percentage recovery of adult worms...Full Text Available

1972-01-01

197

Brg1 Is Required for Cdx2-Mediated Repression of Oct4 Expression in Mouse Blastocysts

We report the isolation of cDNA clones for the mouse {alpha}7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind a-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse {alpha}7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The {alpha}7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 {+-}1.7 cM-Gas2-0.9 cM {+-} 0.9 cM-D7Mit70-1.8 {+-} 1.2 cM- Acra7-4.4 {+-}1.0 cM-Hras1-ps11/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14. 26 refs., 3 figs.

1995-03-20

198

Activation of PPAR? induces profound multilocularization of adipocytes in adult mouse white adipose tissues

During blastocyst formation the segregation of the inner cell mass (ICM) and trophectoderm is governed by the mutually antagonistic effects of the transcription factors Oct4 and Cdx2. Evidence indicates...Full Text Available

199

Abrogation of E-Cadherin-Mediated Cellular Aggregation Allows Proliferation of Pluripotent Mouse Embryonic Stem Cells in Shake Flask Bioreactors

We sought to determine the effects of activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) on multilocularization of adipocytes in adult white adipose tissue (WAT). Male...Full Text Available

2009-12-31

200

A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells

BackgroundA fundamental requirement for the exploitation of embryonic stem (ES) cells in regenerative medicine is the ability to reproducibly derive sufficient numbers of cells of...Full Text Available

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201

A Novel Mouse Model of Red Blood Cell Storage and Post-Transfusion in Vivo Survival

Cultured mouse or human embryonic stem (ES) cells provide access to all of the genes required to elaborate the fundamental components and physiological systems of a mammalian cell. Chemical or insertional...Full Text Available

2009-04-01

202

A Mouse Model Expressing a Truncated Form of Ameloblastin Exhibits Dental and Junctional Epithelium Defects

BackgroundStorage of RBCs is necessary for an adequate blood supply. However, reports have identified potential negative sequelae of transfusing stored RBCs. An animal...Full Text Available

2009-08-01

203

A DNA transposon-based approach to validate oncogenic mutations in the mouse

SUMMARYAmeloblastin (AMBN) is the second most abundant extracellular matrix protein produced by the epithelial cells called ameloblasts and is found mainly in forming dental enamel....Full Text Available

2009-06-01

204

The circadian rhythm for the number and sensitivity of radiation-induced apoptosis in the crypts of mouse small intestine

Large-scale cancer genome projects will soon be able to sequence many cancer genomes to comprehensively identify genetic changes in human cancer. Genome-wide association studies have also identified...Full Text Available

2008-12-16

205

The neuronal nicotinic acetylcholine receptor {alpha}7 subunit gene: Cloning, mapping, structure, and targeting in mouse

Survival curves were constructed from dose-incidence curves for apoptosis in the crypts of mouse small intestine, using the number of apoptotic cells after high doses (N{sub M}) as maximum cell population size. The mean lethal doses (D{sub 0}) for the dose range 0-0.5 Gy were calculated for each time of day. A circadian rhythm in both D{sub 0} and N{sub M} values was detected, indicating that both the number and sensitivity of radiation-induced apoptosis were changing throughout the day. (author).

1990-07-01

206

Ultraviolet radiation for the sterilization of contact lenses

The neuronal nicotinic acetylcholine receptor {alpha}7 subunit is a member of a family of ligand-gated ion channels, and is the only subunit know to bind {alpha}-bungarotoxin in mammalian brain. {alpha}-Bungarotoxin binding sites are known to be more abundant in the hippocampus of mouse strains that are particularly sensitive to nicotine-induced seizures. The {alpha}7 receptor is highly permeable to calcium, which could suggest a role in synaptic plasticity in the nervous system. Auditory gating deficiency, an abnormal response to a second auditory stimulus, is characteristic of schizophrenia. Mouse strains that exhibit a similar gating deficit have reduced hippocampal expression of the {alpha}7 subunit. We have cloned and sequenced the full length cDNA for the mouse {alpha}7 gene (Acra-7) and characterized its gene structure. The murine {alpha}7 shares amino acid identity of 99% and 93% with the rat and human {alpha}7 ...

1994-09-01

207

Ultraviolet radiation for the sterilization of contact lenses

Two sources of ultraviolet (UV) radiation with peak wavelengths in the UV-C or UV-B ranges were compared for their ability to sterilize contact lenses infected with Pseudomonas aeruginosa, Streptococcus pneumoniae, Acanthamoeba castellani, Candida albicans, and Aspergillus niger. Also examined was the effect of prolonged UV light exposure on soft and rigid gas permeable (RGP) contact lenses. The UV-C lamp (253.7 nm, 250 mW/cm2 at 1 cm) was germicidal for all organisms within 20 minutes but caused destruction of the soft lens polymers within 6 hours of cumulative exposure. UV-C caused damage to RGP lenses in less than 100 hours. The UV-B lamp (290-310 nm, 500 mW/cm2 at 1 cm) was germicidal for all organisms tested (except Aspergillus) with a 180-minute exposure and caused less severe changes in the soft lens polymers than did the UV-C lamp, although cumulative exposure of 300 hours did substantially weaken the soft lens material. RGP materials were minimally ...

1990-10-01

208

Extreme Ultraviolet Emission from Abell 4059

Two sources of ultraviolet (UV) radiation with peak wavelengths in the UV-C or UV-B ranges were compared for their ability to sterilize contact lenses infected with Pseudomonas aeruginosa, Streptococcus pneumoniae, Acanthamoeba castellani, Candida albicans, and Aspergillus niger. Also examined was the effect of prolonged UV light exposure on soft and rigid gas permeable (RGP) contact lenses. The UV-C lamp (253.7 nm, 250 mW/cm2 at 1 cm) was germicidal for all organisms within 20 minutes but caused destruction of the soft lens polymers within 6 hours of cumulative exposure. UV-C caused damage to RGP lenses in less than 100 hours. The UV-B lamp (290-310 nm, 500 mW/cm2 at 1 cm) was germicidal for all organisms tested (except Aspergillus) with a 180-minute exposure and caused less severe changes in the soft lens polymers than did the UV-C lamp, although cumulative exposure of 300 hours did substantially weaken the soft lens material. RGP materials were minimally ...

209

Ultraviolet-B Phototoxicity and Hypothetical Photomelanomagenesis: Intraocular and Crystalline Lens Photoprotection

We present the results of a search for Extreme Ultraviolet emission in A4059, a cluster with an X-ray emitting cluster gas. Our analysis of Extreme Ultraviolet Explorer (EUVE) Deep Survey observations of this cluster shows that it is associated with diffuse EUV emission. Outside the central 2 arcmin radius the entire EUV emission detected is explained by the low energy tail of the X-ray emitting gas. Within the central 2 arcmin region of the cluster we find a deficit of EUV emission compared to that expected from the X-ray gas. This flux deficit is discussed in the context of the cluster's cooling flow. The results derived for A4059 are compared to EUVE results obtained for other clusters such as Coma, Virgo, A1795, and A2199. As part of the study we have carried out a detailed investigation of the stability of the EUVE Deep Survey detector background. Based on long integrations of blank sky over 27 months we disprove claims of substantial time ...

2000-01-01

210

British Library Electronic Table of Contents (United Kingdom)

Purpose Ultraviolet-B (UV-B) radiation can cause phototoxic macular injuries in young people who have been sunbathing but not sungazing and in welders. Welders have a reportedly increased risk of uveal melanoma. We analyze phakic and pseudophakic risks for solar and welding arc UV-B exposure. Design Optical radiation measurement, analysis, and perspective. Methods Spectral transmittances were measured for UV-transmitting, UV-blocking, and blue-blocking intraocular lenses (IOLs). The photoprotective performances of crystalline and intraocular lenses were analyzed using relevant epidemiologic and laboratory data and action spectra for acute retinal phototoxicity and melanoma photocarcinogenesis. Results Crystalline lens UV-B retinal protection is deficient in children and young adults, incre...

2010-01-01

211

Ultraviolet detectors based on ZnO films by thermal oxidation of Zn metallic films

British Library Electronic Table of Contents (United Kingdom)

Metallic Zn films were deposited on glass substrates by electron-beam evaporation. ZnO films were synthesized by thermal oxidation of Zn metallic films in air. At the annealing temperature of 550 ?C, ZnO nanowires appeared on the surface, which mainly result from the decrease of oxidation rate. A ZnO ultraviolet photodetector was fabricated based on a metal-semiconductor-metal planar structure. The detector showed a large UV photoresponse with an increase of two orders of magnitude. It is concluded that promising UV detectors can be obtained on ZnO films by thermal oxidation of Zn metallic films. The ways of performing spectral response measurements for polycrystalline ZnO films are also discussed.

2008-01-01

212

Thin-film UV detectors based on hydrogenated amorphous silicon and its alloys

The VOISE Algorithm: a Versatile Tool for Automatic Segmentation of Astronomical Images

Thin film ultraviolet detectors based on hydrogenated amorphous silicon alloys are realized with different diode structures (PIN, NIP, PN, and NP). The PIN and NIP detectors exhibit higher sensitivity in the ultraviolet spectrum and a significant lower dark current in comparison to the PN or NP structures. The best detector performance was achieved with a 33 nm thick PIN diode. This detector shows a maximum of quantum efficiency of 36.3% at a wavelength of 310 nm. By varying the thickness of the semi-transparent Ag front contact the selectivity of the detectors with the quantum efficiency peak at 320 nm can be adjusted. Thus, the spectral sensitivity of the detector shifts from a broad UV to a selective UV-B spectrum. (orig.)

2001-05-16

213

Liquid chromatography with ultraviolet and dual parallel mass spectrometric detection for analysis of vitamin D in retail fortified orange juice

The auroras on Jupiter and Saturn can be studied with a high sensitivity and resolution by the Hubble Space Telescope (HST) ultraviolet (UV) and far-ultraviolet (FUV) Space Telescope spectrograph (STIS) and Advanced Camera for Surveys (ACS) instruments. We present results of automatic detection and segmentation of Jupiter's auroral emissions as observed by HST ACS instrument with VOronoi Image SEgmentation (VOISE). VOISE is a dynamic algorithm for partitioning the underlying pixel grid of an image into regions according to a prescribed homogeneity criterion. The algorithm consists of an iterative procedure that dynamically constructs a tessellation of the image plane based on a Voronoi Diagram, until the intensity of the underlying image within each region is classified as homogeneous. The computed tessellations allow the extraction of quantitative information about the auroral features such as mean intensity, latitudinal and longitudinal ...

2009-01-01

214

British Library Electronic Table of Contents (United Kingdom)

Samples of vitamin D fortified orange juice obtained from retail food stores were analyzed for vitamin D3 content using a method developed by combining the best features of two AOAC methods. Detection by ultraviolet absorption at 265nm was compared to detection by selected ion monitoring (SIM) using atmospheric pressure chemical ionization (APCI) mass spectrometry (MS). Furthermore, an ion trap (IT) mass spectrometer was employed in a 'dual parallel MS' arrangement to simultaneously obtain qualitative APCI-ITMS data. The method was applied to 33 samples of 3 national American orange juice brands and 7 samples of 5 other American brands collected using a statistically designed sampling plan as part of the National Food and Nutrient Analysis Program to provide values for the USDA National Nu...

2011-01-01

215

FUV and X-ray absorption in the Warm-Hot Intergalactic Medium

Detection of Free-Living Amoebae in Some Water Sources and its Control by Ultraviolet- Radiation

The Warm-Hot Intergalactic Medium (WHIM) arises from shock-heated gas collapsing in large-scale filaments and probably harbours a substantial fraction of the baryons in the local Universe. Absorption-line measurements in the ultraviolet (UV) and in the X-ray band currently represent the best method to study the WHIM at low redshifts. We here describe the physical properties of the WHIM and the concepts behind WHIM absorption line measurements of H I and high ions such as O VI, O VII, and O VIII in the far-ultraviolet and X-ray band. We review results of recent WHIM absorption line studies carried out with UV and X-ray satellites such as FUSE, HST, Chandra, and XMM-Newton and discuss their implications for our knowledge of the WHIM.

2008-01-01

216

Composition and method for encapsulating photovoltaic devices

Among the numerous free-living amoebae (FLA) of soil and water habitats, certain species belonging to two genera Acanthamoeba and Naegleria are facultative parasites of man.They cause disease called primary amoebic meningoencephalitis where history of contact with water was recorded in most of the cases especially with Naegleria species. The present work aimed to search for presence of free-living amoebae in the water and trials for its control by Ultraviolet-radiation (UV-radiation). Samples from different water sources were examined for the presence of free-living amoebae. These samples were cultured on non-nutrient agar streaked with bacteria. Amoebae were detected and identified by means of their morphological characters. Twelve positive cases of one hundred and twenty examined samples could be detected. The positive samples were exposed to different doses of UV-radiation for different times.

217

Characteristics of lanthanides in pyrochemical systems observed by electrochemical and spectrophotometric measurements

A composition and method for encapsulating a photovoltaic device which minimizes discoloration of the encapsulant. The composition includes an ethylene-vinyl acetate encapsulant, a curing agent, an optional ultraviolet light stabilizer, and/or an optional antioxidant. The curing agent is preferably 1,1-di-(t-butylperoxy)-3,3,5-trimethylcyclohexane; the ultraviolet light stabilizer is bis-(N-octyloxy-tetramethyl) piperidinyl sebacate and the antioxidant is selected from the group consisting of tris (2,4-di-tert-butylphenyl) phosphite, tetrakis methylene (3,5-di-tert-butyl-4-hydroxyhydrocinnamate) methane, octadecyl 3,5-di-tert-butyl-4-hydroxyhydrocinnamate, and 2,2'-ethylidene bis(4,6-di-t-butylphenyl) fluorophosponite. The composition is applied to a solar cell then cured. The cured product contains a minimal concentration of curing-generated chromophores and resists UV-induced degradation.

2000-01-01

218

Irradiation hardening of reduced activation martensitic steels

As research for the chemical properties of lanthanide molecules in the dry system, electrochemical and ultraviolet-visible optical measurements on the chloride molten salt system have been conducted at Research Reactor Institute, Kyoto University. The reduction behavior of Ln(III)-Ln(0) and Ln(II) are measured on La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, and Yb by the cyclic voltammetry. The molar absorption coefficients of the f-f transition are measured by the measurement of ultraviolet-visible absorption spectra on Pr, Nd, Ho and Gd. From the comparison of the optical data between wet and dry systems, the characteristics of photon absorption are discussed in the molten salt. (H. Katsuta)

2001-12-01

219

Concrete peeling off device

Irradiation response on the tensile properties of 9Cr-2W steels has been investigated following FFTF/MOTA irradiations at temperatures between 646 and 873 K up to doses between 10 and 59 dpa. The largest irradiation hardening accompanied by the largest decrease in the elongation is observed for the specimens irradiated at 646 K at doses between 10 and 15 dpa. The irradiation hardening appears to saturate at a dose of around 10 dpa at the irradiation temperature. No hardening but softening was observed in the specimens irradiated at above 703 K to doses of 40 and 59 dpa. Microstructural observation by transmission electron microscope (TEM) revealed that the dislocation loops with the a left angle 100 right angle type Burgers vector and small precipitates which were identified to be M_6C type carbides existed after the ...

220

Neutron irradiation effects on plasma facing materials

The present invention concerns a device for peeling off activated concretes in processing for discarding a reactor of a nuclear reactor facility. The device comprises a gyrotron for generation microwaves, an irradiator for irradiating output microwaves, a reflection mirror for reflecting and converging the microwaves and irradiating them to a material to be irradiated and a first rotating means for rotating the irradiator and the reflection mirror in parallel with the axis of the gyrotron while maintaining the positional relation between the irradiator and the reflection mirror. When the position of the microwaves irradiated on concrete walls are moved in a circumferential direction and the central axes of the rotational axis and the material to be irradiated are aligned, then the intensity of the ...

1997-11-28

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

221

Irradiation damage in superconductors

This paper reviews the effects of neutron irradiation on thermal and mechanical properties and bulk tritium retention of armour materials (beryllium, tungsten and carbon). For each material, the main properties affected by neutron irradiation are described and the specific tests of neutron irradiated armour materials under thermal shock and disruption conditions are summarized. Based on current knowledge, the expected thermal and structural performance of neutron irradiated armour materials in the ITER plasma facing components are analysed.

2000-12-01

222

Differential Effect of Irradiance and Nutrient Nitrate on the Relationship of in Vivo and in Vitro Nitrate Reductase Assay in Chlorophyllous Tissues ¹

Most superconductors are quite sensitive to irradiation defects. Critical temperatures may be depressed, critical currents may be increased, by irradiation, but other behaviours may be encountered. In compounds, the sublattice in which defects are created is of significant importance. 24 refs.

1989-05-08

223

Consideration of radiation effects in the choice of packaging materials

Growth at increasing continuous irradiance (at high nutrient nitrate) and nutrient nitrate concentrations (at high continuous irradiance) furnished increases in the in vivo and in...Full Text Available

1977-04-01

224

The neurological mouse mutations jittery and hesitant are allelic and map to the region of mouse chromosome 10 homologous to 19p13.3

Requirements for food packaging materials include whether there is any interaction between the food and the package during or after the irradiation, and whether as a result of the irradiation, volatile or leachable substances are released from the pack into the food. The performance of cellulose-based materials and plastic films under irradiation are discussed.

225

Study of the effects of a prenatal or postnatal irradiation of 150 rads in adult rats

Jittery (ji) is a recessive mouse mutation on Chromosome 10 characterized by progressive ataxic gait, dystonic movements, spontaneus seizures, and death by dehydration/starvation before fertility. Recently, a viable neurological recessive mutation, hesitant, was discovered. It is characterized by hesitant, uncoordinated movements, exaggerated stepping of the hind limbs, and reduced fertility in males. In a complementation test and by genetic mapping we have shown here that hesitant and jittery are allelic. Using several large intersubspecific backcrosses and intercrosses we have genetically mapped ji near the marker Amh and microsatellite markers D10Mit7, D10Mit21, and D10Mit23. The linked region of mouse Chromosome 10 is homologous to human 19p13.3, to which several human ataxia loci have recently been mapped. By excluding genes that map to human 21q22.3 (Pfkl) and 12q23 (Nfyb), we conclude that jittery is not likely to be a genetic ...

1996-08-01

226

Irradiation effects on passive films formed on a 304 Type stainless steel

Pregnant females and newborn rats were exposed to a gamma irradiation of 150 rads. The stage of gestation at the time of irradiation varied from 14 to 21 days. The newborn rats were irradiated at 0, 1 and 2 days of age. The effect of irradiation of foetus and newborn rats depends on the age of the animal at the time of irradiation. This effect was specially important at the beginning of the foetal life. Neonatal mortality, growth of body weight and adult brain development were investigated. A modification of germ cell radiosensitivity during the period studied, was emphasized.

227

Irradiation effects on passive films formed on a 304 Type stainless steel

The effects of {alpha} particle irradiation on a passive film formed on a 304 type stainless steel are studied in situ. The experimental arrangement minimizes the radiolysis effects due to the electrolyte. Under irradiation, a modification of the electronic structure of the oxide layers is revealed by photo-electrochemistry and impedance measurements. The influence of irradiation on the corrosion resistance of the passive film is investigated. Comparing the rest potential and the breakdown potential respectively under and without irradiation, a drop in the passivity range under irradiation is shown. this is interpreted as a decrease in the corrosion resistance. (author).

1990-01-01

228

Temperature dependence of the performance of ultraviolet detectors

The effects of #alpha# particle irradiation on a passive film formed on a 304 type stainless steel are studied in situ. The experimental arrangement minimizes the radiolysis effects due to the electrolyte. Under irradiation, a modification of the electronic structure of the oxide layers is revealed by photo-electrochemistry and impedance measurements. The influence of irradiation on the corrosion resistance of the passive film is investigated. Comparing the rest potential and the breakdown potential respectively under and without irradiation, a drop in the passivity range under irradiation is shown. this is interpreted as a decrease in the corrosion resistance. (author).

1990-01-01

229

Temperature dependence of the performance of ultraviolet detectors

We present the results of a comprehensive study of the temperature dependences of the quantum efficiency for ultraviolet detectors based on GaAs, GaP and 4H--SiC Schottky structures, and on Si, GaAs p-n structures. For ultraviolet detectors based on Schottky structures, the quantum efficiency increases with increasing temperature for all photon energies, even including the semiconductor intrinsic absorption region. On the other hand, for ultraviolet detectors based on p-n structures, the quantum efficiency is practically temperature independent in the semiconductor intrinsic absorption region. The change in the quantum efficiency for the GaAs and Si detectors is less than 0.01% per degree. To explain the measurements, a variable trap occupancy model is presented. Subsurface imperfections of the semiconductor cause fluctuations in the profile of the conduction band and the valence band edges. In the presence of an electric ...

2003-08-21

230

Spectrophotometric technique quantitatively determines NaMBT inhibitor in ethylene glycol-water solutions

We present the results of a comprehensive study of the temperature dependences of the quantum efficiency for ultraviolet detectors based on GaAs, GaP and 4H--SiC Schottky structures, and on Si, GaAs p-n structures. For ultraviolet detectors based on Schottky structures, the quantum efficiency increases with increasing temperature for all photon energies, even including the semiconductor intrinsic absorption region. On the other hand, for ultraviolet detectors based on p-n structures, the quantum efficiency is practically temperature independent in the semiconductor intrinsic absorption region. The change in the quantum efficiency for the GaAs and Si detectors is less than 0.01% per degree. To explain the measurements, a variable trap occupancy model is presented. Subsurface imperfections of the semiconductor cause fluctuations in the profile of the conduction band and the valence band edges. In the presence of an electric ...

2003-08-21

231

S179D prolactin diminishes the effects of UV light on epidermal gamma delta T cells

Spectrophotometric method, using a ratio-recording ultraviolet-absorption spectrophotometer, permits analysis of NaMBT in ethylene glycol-water solutions with high accuracy. It reduces analysis time, requires smaller samples, and is able to detect extremely small concentrations of mercaptobenzothiazole.

1967-01-01

232

Rayleigh Scattering in Rare Gas Liquids

Epidermal gamma delta T cells (γδ T) and Langerhans cells (LC) are immune cells altered by exposure to ultraviolet radiation (UVB), a powerful stressor resulting in immune suppression....Full Text Available

2008-01-02

233

The Rayleigh scattering length has been calculated for rare-gas liquids in the ultraviolet for the frequencies at which they luminesce. The calculations are based on the measured dielectric constants in the gas phase, except in the case of xenon for which measurements are available in the liquid. The scattering length mayplace constraints on the design of some large-scale detectors, using uv luminescence, being proposed to observe solar neutrinos and dark matter. Rayleigh scattering in mixtures of rare-gas mixtures is also discussed.

2002-01-01

234

Ozone layer

Conductive, spin-cast carbon films from polyacrylonitrile

Governments around the world will soon make decisions on policies that could determine the fate of the ozone layer-the Earth's shield from harmful ultraviolet radiation. The Vienna Convention for the Protection of the Ozone Layer, signed on March 22, 1985, created a framework for scientific cooperation and information exchange that will form the basis for a protocol for controlling substances thought to threaten the ozone layer. As of mid-1987, 29 countries had signed the Convention, including the major producers and users of chlorofluorocarbons (CFCs), the most important of suspect chemicals.

1987-12-01

235

Clinical translation of ultraviolet autofluorescence microscopy towards endomicroscopy for early detection of cancer

Polyacrylonitrile films have been spin cast and pyrolyzed to produce thin (500--1500 A) carbon films. These films have higher electrical conductivities than films produced by other methods at similar temperatures. The conductivity can be varied by at least four orders of magnitude by changing the pyrolysis temperature. Ultraviolet, infrared, and Raman spectroscopies were used to investigate the chemical structure of the films during different stages of processing.

1987-05-18

236

Calculation of general p-adic Feynman amplitude

The non-invasiveness of autofluorescence technology may reduce sampling error and time delay for histopathology diagnosis. We establish biophotonic methods and guidelines to visualize and interpret early epithelial tissue changes that signify disease. Flexible and rigid fiber endomicroscopy instrumentation design parameters feasible for translation towards clinical use are in development.

2010-12-01

237

Yields of Residual Nuclei from Proton-Irradiated Materials

The general n-point massless p-adic Feynman amplitude with arbitrary parameters of analytic regularization for each line is calculated. This result is presented in the form of a sum over hierarchies of a given graph. The structure of ultraviolet and infrared divergences of p-adic Feynman amplitudes is characterized and the star-triangle uniqueness identity in the p-adic case is derived. (orig.).

1992-10-01

238

International Science & Technology Center (ISTC)

Experimental and Theoretical Study of the Residual Nuclide Production in 40-2600 MeV Proton-Irradiated Thin Targets of ADS Basic Materials

239

The sensory quality of irradiated breaded poultry products

Radiation Damage Calculations for the FUBR and BEATRIX Irradiations of Lithium Compounds in EBR-II and FFTF

The colour, odour, flavour and texture of a breaded turkey escalope irradiated at doses of 2 and 4 kGy was assessed using a trained sensory panel. Irradiation did not affect raw appearance but during storage the irradiated breaded products became paler than the control samples. The off odour of the raw irradiated products was stronger than that of the unirradiated samples. Irradiation also affected the odour, flavour and texture of the cooked products. Although the trained panelists were able to detect significant differences between irradiated and unirradiated breaded turkey escalopes, the numerical differences between treatments were often quite small. It is possible that an untrained consumer group would be unable to detect these differences. Further research is needed with consumer groups to establish if irradiated breaded products are ...

1994-07-01

240

Endurance of cultured pearls irradiated with gamma-rays

Radiation Damage Calculations for the FUBR and BEATRIX Irradiations of Lithium Compunds in EBR-II and FFTF

1999-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

241

Dislocation pinning in electron-irradiated copper as a function of electron energy and irradiation

Pearls change their color to grey by #gamma#-ray irradiation. Grey densities were determined from darkness of pearl nuclei and thickness of the pearl layers. The densities are independent of both diameters of nuclei and pearls. The fading rate increases with increasing storage temperature. The rate of fading for irradiated pearls is lower than that for natural blue pearls. Comparison of photomicrographs (x 12) for pearls irradiated and then stored at room temperature for about 6 years revealed that their surfaces are not substantially different from the surfaces of unirradiated cultured pearls, indicating that #gamma# irradiation hardly gives rise to deterioration. #gamma#-Ray irradiation is a technique for coloration of pearls. Irradiated blue pearls seem to have resistivity to fading and to deterioration of the surface, if pearls have been ...

242

Determination of alcohols, esters and organic acids in irradiated sweet potato wine by capillary gas chromatography

Dislocation priming measurements were performed in the kHz range in ASARCO copper. The samples and irradiation facilities are constructed so as to allow successive irradiation of samples both with electrons and gamma rays. The gamma rays were produced by stopping 2.8-MeV electrons in a gold target. The change of the type of irradiation could be achieved without any handling of the sample. Thus it is possible to detect rather small differences between the two types of irradiation. Recovery experiments at 400 deg K after 75 deg K irradiation and pinning rates during irradiation at 400 deg K and 75 deg K were made. (GE)

1973-01-01

243

Determination of absorbed dose in a patient irradiated by beams of x or gamma rays in radiotherapy procedures

This paper presents the analytical results of alcohols, esters and organic acids in sweet potato wine irradiated by #gamma#-rays. (author).

244

Coloring of cultured pearls by gamma-rays irradiation

Determination of absorbed dose in a patient irradiated by beams of x or gamma rays in radiotherapy procedures

1976-01-01

245

cDNA cloning, sequence analysis and organ distribution of horse preproendothelin-2.

Changing cream pearls into bluish-grey by #gamma# ray irradiation is a technique in coloring of pearls. Irradiated pearls are similar in color to cultured blue pearls. The pearl layers hardly change their color but the nuclei change into dark brown by irradiation. Visible light (500 - 700 nm) penetrating the pearl layer is absorbed by dark brown nucleus. The intensity of reflecting light between 400 and 500 nm at pearl surface, therefore, becomes stronger than that between 500 and 700 nm; therefore color of irradiated pearls look bluish-grey. The density of bluish-grey color increases with increasing absorbed doses, but their luster at surface diminishes owing to the deterioration of the pearl layer by prolonged irradiation; high doses irradiation should be avoided. Irradiated pearls show no substantial fading of their color in a year and ...

246

Yeast artificial chromosome libraries containing large inserts from mouse and human DNA

We cloned and characterized horse preproendothelin-2 (PPET-2) cDNA from intestinal tissue. The cDNA encoded 178 amino acids of the PPET-2 polypeptide, in which a 21-amino-acid mature endothelin-2 peptide and a 16-amino acid endothelin-2-like peptide were found. For the open reading frame the correspondence of horse PPET-2 cDNA with those of the ferret, human, dog, mouse and rat was 85.1%, 84.9%, 82.1%, 77.8% and 77.2%, respectively. Analysis of the organ distribution of PPET-2 mRNA by reverse transcription-polymerase chain reaction demonstrated that the kidney, stomach and small intestine are major sites of expression of the PPET-2 gene. Surprisingly, the mRNA is not detected in the large intestine, where high expression is demonstrated in the mouse and rat. This difference may result from the underlying functional differences of the large intestine between a herbivore (horse) and an omnivore (mouse and rat). PMID:15838341

2004-11-01

247

Long-term Retinal Function and Structure Rescue Using Capsid Mutant AAV8 Vector in the rd10 Mouse, a Model of Recessive Retinitis Pigmentosa

Yeast artificial chromosome (YAC) libraries have been difficult to construct with average insert sizes >400 kilobase pairs when DNA is size-fractionated in low-melting-point agarose. By using yeast chromosomes in mock cloning experiments, the authors found that polyamines should be present whenever agarose containing high molecular weight DNA is melted to protect DNA from degradation. By incorporating polyamines during the cloning procedure, they constructed YAC libraries from mouse and human DNA with average insert sizes of 700 and 620 kilobase pairs, respectively. Several genome equivalents of these YAC libraries were replicated onto the surface of many duplicate agar plates using a 40,000 multipin transfer device. High-density filter replicas were screened by hybridization, and 70 mouse YAC clones from 31 loci and 132 human YAC clones from 49 loci were isolated.

1991-05-15

248

British Library Electronic Table of Contents (United Kingdom)

The retinal degeneration 10 (rd10) mouse is a well-characterized model of autosomal recessive retinitis pigmentosa (RP), which carries a spontaneous mutation in the ? subunit of rod cGMP-phosphodiesterase (PDE?). Rd10 mouse exhibits photoreceptor dysfunction and rapid rod photoreceptor degeneration followed by cone degeneration and remodeling of the inner retina. Here, we evaluate whether gene replacement using the fast-acting tyrosine-capsid mutant AAV8 (Y733F) can provide long-term therapy in this model. AAV8 (Y733F)-smCBA-PDE? was subretinally delivered to postnatal day 14 (P14) rd10 mice in one eye only. Six months after injection, spectral domain optical coherence tomography (SD-OCT), electroretinogram (ERG), optomotor behavior tests, and immunohistochemistry showed tha...

2011-01-01

249

Inhibitory effect of minocycline on osteoclastogenesis in mouse bone marrow cells

British Library Electronic Table of Contents (United Kingdom)

Objective: To study the effects of minocycline hydrochloride (MINO) on the formation of tartrate-resistant acid phosphatase (TRAP) staining-positive multinucleated osteoclast-like cells in mouse bone marrow cells (BMCs) treated with 1@a,25(OH)"2D"3 or soluble receptor activator of nuclear factor-@kB ligand (s-RANKL). Materials and methods: Mouse BMCs were cultured in alpha-modified minimum essential medium containing foetal calf serum (10%) and tetracyclines (2.5, 5 and 10@mM), such as MINO, tetracycline hydrochloride (TC), oxytetracycline hydrochloride (OXT) or doxycycline (DOXY) in the presence of 1@a,25(OH)"2D"3 (10nM) or s-RANKL (20ng/ml) for 7 days, and the number of TRAP staining-positive osteoclast-like cells was counted. In RNA isolated from BMCs treated with 1@a,25(OH)"2D"3 or s-R...

2011-01-01

250

Absence of linkage of apparently single gene mediated ADHD with the human syntenic region of the mouse mutant coloboma

Irradiation of spices, packaging materials and luncheon to improve the storability of the end product

Attention deficit disorder (ADHD) is a complex biobehavioral phenotype which affects up to 8% of the general population and often impairs social, academic, and job performance. Its origins are heterogeneous, but a significant genetic component is suggested by family and twin studies. The murine strain, coloboma, displays a spontaneously hyperactive phenotype that is responsive to dextroamphetamine and has been proposed as a genetic model for ADHD. Coloboma is a semi-dominant mutation that is caused by a hemizygous deletion of the SNAP-25 and other genes on mouse chromosome 2q. To test the possibility that the human homolog of the mouse coloboma gene(s) could be responsible for ADHD, we have carried out linkage studies with polymorphic markers in the region syntenic to coloboma (20p11-p12). Five families in which the pattern of inheritance of ADHD appears to be autosomal dominant were studied. Segregation analysis of the traits studied suggested ...

1995-12-18

251

The numerical response of breeding Northern Saw-whet Owls Aegolius acadicus suggests nomadism

Spices and packaging materials were exposed to gamma irradiation at a dose of 10 KGy. Luncheon was prepared with irradiated or non-irradiated spices. Prepared luncheon was packaged in irradiated or non-irradiated packaging materials. Packaged luncheon was treated with 2 KGy. Treated and untreated packaged luncheon were kept in a refrigerator (1-4 Centigrade) for 12 months. Microbiological, nutritive and chemical characteristics of luncheon were evaluated after processing and during storage; whereas, sensory quality was evaluated only after irradiation. Gamma irradiation decreased the microorganisms counts of spices, packaging materials and packed luncheon and increased the shelf-life of packaged luncheon products. No major differences in moisture, protein, fat, ph value, total acidity, lipid peroxide and volatile basic nitrogen were observed ...

252

British Library Electronic Table of Contents (United Kingdom)

We used a 13-year time series of abundance estimates of breeding Northern Saw-whet Owls (Aegolius acadicus), and of small mammals from central Ontario, Canada, to assess the numerical response of the owls to small-mammal prey species. We found that the finite rate of increase of breeding owls was directly related to estimates of red-backed vole (Myodes gapperi) abundance. Thus, it appeared that the owls were nomadic, and made decisions about where to breed based on vole supply. The owls showed a much weaker response to deer mouse (Peromyscus maniculatus) abundance. Across all years, 55% of variation in owl rate of increase could be uniquely attributed to vole abundance, whereas only 3% could be attributed to mouse abundance. Consistent with the model of nomadism, there was only a weak rela...

2010-01-01

253

The effect of the venom of the yellow Iranian scorpion Odontobuthus doriae on skeletal muscle preparations in vitro

British Library Electronic Table of Contents (United Kingdom)

The yellow Iranian scorpion Odontobuthus doriae can cause fatal envenoming, but its mechanism of action is unclear. One of the reported manifestations of envenoming is moderate to severe involuntary tremor of skeletal muscle. In order to understand better the mechanism of action of this venom on skeletal muscle function, we examined the effects of the venom in vitro on chick biventer cervicis (CBC) and mouse hemidiaphragm (MHD) nerve muscle preparations. O. doriae venom (0.3-10mg/ml) initially increased and then decreased twitch height. The venom also caused contracture in both preparations. In mouse triangularis sterni preparations, used for all intracellular recording techniques, the venom enhanced the release of acetylcholine and induced repetitive firing of nerve action potentials and ...

2007-01-01

254

Nickel induced structural and functional alterations in mouse Leydig cells in vitro

British Library Electronic Table of Contents (United Kingdom)

The present study was aimed at investigating effects of nickel (NiCl2) on secretion of testosterone (T), cell viability, ultrastructure and apoptosis in mouse Leydig cells. Testosterone release was measured after 48h of culture with 15.67, 31.25, 62.5, 125, 250, 500 and 1000mmol/L NiCl2 or without NiCl2 using radioimmunoassay. Cell viability was assessed by a MTT (metabolic activity assay). Quantification of apoptotic cells was performed using TUNEL assay and the ultrastructural changes were analyzed using transmission electron microscopy. The viability was decreased after addition of >=250mmol/L NiCl2. A concentration-dependent depression of T production was observed. The percentage of apoptotic cells was significantly increased only after addition of 125, 250 and 1000mmol/L NiCl2. After ...

2011-01-01

255

Mary Lyon and the hypothesis of random X chromosome inactivation

British Library Electronic Table of Contents (United Kingdom)

The 50th anniversary of Mary Lyon?s 1961 Nature paper, proposing random inactivation in early embryonic life of one of the two X chromosomes in the cells of mammalian females, provides an opportunity to remember and celebrate the work of those involved. While the hypothesis was initially put forward by Lyon based on findings in the mouse, it was founded on earlier studies, notably the work of Susumu Ohno; it was also suggested independently by Beutler and colleagues using experimental evidence from a human X-linked disorder, glucose-6-phosphate dehydrogenase deficiency, and has proved to be of as great importance for human and medical genetics as it has for general mammalian genetics. Alongside the hypothesis itself, previous cytological studies of mouse and human chromosomes, and the obse...

2011-01-01

256

Interspecies Trait Genetics Reveals Association of Adcy8 with Mouse Avoidance Behavior and a Human Mood Disorder

British Library Electronic Table of Contents (United Kingdom)

Background Identifying susceptibility genes for endophenotypes by studying analogous behaviors across species is an important strategy for understanding the pathophysiology underlying psychiatric disorders. This approach provides novel biological pathways plus validated animal models critical for selective drug development. One such endophenotype is avoidance behavior. Methods In the present study, novel automated registration methods for longitudinal behavioral assessment in home cages are used to screen a panel of recently generated mouse chromosome substitution strains that are very powerful in quantitative trait loci (QTL) detection of complex traits. In this way, we identified chromosomes regulating avoidance behavior (increased sheltering preference) independent of motor activity lev...

2009-01-01

257

Genomic survey of prepulse inhibition in mouse chromosome substitution strains

British Library Electronic Table of Contents (United Kingdom)

Prepulse inhibition (PPI) is a measure of sensorimotor gating, a pre-attentional inhibitory brain mechanism that filters extraneous stimuli. Prepulse inhibition is correlated with measures of cognition and executive functioning, and is considered an endophenotype of schizophrenia and other psychiatric illnesses in which patients show PPI impairments. As a first step toward identifying genes that regulate PPI, we performed a quantitative trait locus (QTL) screen of PPI phenotypes in a panel of mouse chromosome substitution strains (CSSs). We identified five CSSs with altered PPI compared with the host C57BL/6J strain: CSS-4 exhibited decreased PPI, whereas CSS-10, -11, -16 and -Y exhibited higher PPI compared with C57BL/6J. These data indicate that A/J chromosomes 4, 10, 11, 16 and Y harbor...

2009-01-01

258

Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters

British Library Electronic Table of Contents (United Kingdom)

Research on hematological disorders relies on suitable animal models. We retrospectively evaluated the use of the hematological parameters hematocrit (HCT), hemoglobin (HGB), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), red blood cell count (RBC), white blood cell count (WBC), and platelet count (PLT) in the phenotype-driven Munich N-ethyl-N-nitrosourea (ENU) mouse mutagenesis project as parameters for the generation of novel animal models for human diseases. The analysis was carried out on more than 16,000 G1 and G3 offspring of chemically mutagenized inbred C3H mice to detect dominant and recessive mutations leading to deviations in the levels of the chosen parameters. Identification of animals exhibiting altered valu...

2011-01-01

259

Evidence for Epigenetic Interactions for Loci on Mouse Chromosome 1 Regulating Open Field Activity

British Library Electronic Table of Contents (United Kingdom)

The expression of motor activity levels in response to novel situations is under complex genetic and environmental control. Several genetic loci have been implicated in the regulation of this behavioral phenotype, but their relationship to epigenetic and epistatic interactions is relatively unknown. Here, we report on a quantitative trait locus (QTL) on mouse chromosome 1 for novelty-induced motor activity in the open field, using chromosome substitution strains derived from a high active host strain (C57BL/6J) and a low active donor strain (A/J). The QTL for open field (horizontal distance moved) peaked at the location of Kcnj9, however, QTL detection was initially masked by an interplay of both grandparent genetic origin and genetic co-factors influencing behavior on chromosome 1. Our fi...

2009-01-01

260

Effects of retinoic acid on maturation of immature mouse oocytes in the presence and absence of a granulosa cell co-culture system

British Library Electronic Table of Contents (United Kingdom)

Purpose Evaluation of the all-trans retinoic acid (t-RA) effects on in vitro maturation (IVM) and in vitro fertilization (IVF) of immature mouse oocytes in the presence and absence of granulosa cell monolayer. Methods Denuded oocytes isolated from mice ovaries and matured in IVM medium alone (Control I), IVM medium in the presence of granulosa cells (Control II), IVM medium with t-RA (Experimental I) and IVM medium simultaneously with t-RA and granulosa cells (Experimental II). After 24?h, matured oocytes were fertilized in T6 medium and their development was followed until the blastocyst stage. Metaphase II oocytes ploidy were evaluated by chromosome counting. Results The t-RA group compared to the control groups showed no obvious abnormalities. Additionally maturation and embryo developm...

2011-01-01

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261

Ectopic mineralization of connective tissue in Abcc6-/- mice: effects of dietary modifications and a phosphate binder - a preliminary study

British Library Electronic Table of Contents (United Kingdom)

Please cite this paper as: Ectopic mineralization of connective tissue in Abcc6-/- mice: effects of dietary modifications and a phosphate binder - a preliminary study. Experimental Dermatology 2008; 17: 203-207. Abstract: Pseudoxanthoma elasticum (PXE), a heritable multisystem disorder, is caused by mutations in the ABCC6 gene. We have developed a murine model for PXE by targeted inactivation of the corresponding mouse gene. A feature of this mouse model is ectopic mineralization of connective tissue capsule surrounding the bulb of vibrissae. This study was designed to investigate the effect of dietary sevelamer hydrochloride (Renagel), a phosphate binder, and specific mineral modifications on ectopic mineralization of connective tissue in Abcc6-/- mice. Three groups were fed a specific di...

2008-01-01

262

Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule

British Library Electronic Table of Contents (United Kingdom)

Excessive physical activity plays an important role in the progression of anorexia nervosa (AN) by accelerating weight loss during dietary restriction. To search for mechanisms underlying this trait, a panel of mouse chromosome substitution strains derived from C57BL/6J and A/J strains was exposed to a scheduled feeding paradigm and to voluntary running wheel (RW) access. Here, we showed that A/J chromosomes 4, 12 and 13 contribute to the development of a disrupted RW activity in response to daily restricted feeding. This pattern is characterized by intense RW activity during the habitual rest phase and leads to accelerated body weight loss. Regions on mouse chromosomes 4, 12 and 13 display homology with regions on human chromosomes linked with anxiety and obsessionality in AN cohorts. The...

2010-01-01

263

Characterization of the platelet-aggregating activity of tumor cells. [Mice

Treatment of uteral cancer by the brake irradiation (25 MeV)

Two lines of mouse tumor cells were shown to be capable of aggregating mouse and rabbit platelets in vitro. This process required higher Mg/sup 2 +/ concentrations than were needed by other commonly used platelet-aggregating agents. Platelet-aggregating activity was also found in tumor cell membrane fragments. This membrane-bound platelet-aggregating material contained protein, lipid, and carbohydrate moieties. The presence of all three appeared to be essential for stimulating platelet aggregation. Destruction of any component abolished its activity. Platelet aggregation induced by tumor cell membrane fragments was associated with a secretory release reaction. In this process, growth-promoting activity for tumor cells was also released from platelets. These results underline the importance of platelets in establishing tumor metastases.

1980-04-01

264

Thermal decomposition of gamma irradiated proteins by thermal analysis methods

The method of treatment of uteral cancer by the brake irradiation of 25 MeV betatrone using original devices which promote forming therapeutic figured bunches is presented. The binding of the protective blocks with a special adjusting frame within the aperture of the diaphragm provided for low relative entering dose which is the advantage of high energy irradiation bunch. The use of the forming devices makes it possible to practice individual treatment and decrease the levels of irradiation doses for intact organs and tissues.

265

Study of nuclear fusion materials making use of ion irradiation and ESR microscope

Short communication. 2 figs.

1996-12-31

266

Statistical cut-off criterion

No abstract prepared

1998-01-01

267

Some comments on BEIR III

... radiation effects human populations low dose irradiation neoplasms radiation

1980-01-01

268

Radiation processing used in forestry in Thailand

... organizations irradiation radiation doses radiation effects RADIATIONS.

1982-01-01

269

Potential Detection of Irradiated Dried Agricultural Products by Viscosity Measurement

A summary is presented of research being carried out in Thailand on the preparation of irradiation-impregnated wood.

1981-01-01

270

Market trials of irradiated chicken

Full Text Available

1999-10-01

271

Lung irradiation for paraquat toxicity

The potential market for irradiated chicken breasts was investigated using a mail survey and a retail trial. Results from the mail survey suggested a significantly higher level of acceptability of irradiated chicken than did the retail trial. A subsequent market experiment involving actual purchases showed levels of acceptability similar to that of the mail survey when similar information about food irradiation was provided.

1998-06-01

272

Influencing factors on ESR dose assessment in irradiated chicken legs

(Nov 1985). United Kingdom Williams, MV Addenbrooke's Hospital,

273

Influence of production technology and irradiation conditions on radiation hardening of reactor vessel steels

Electron spin resonance (ESR) dosimetry of irradiated chicken legs is based on the additive dose or the calibration curve methods. In both cases the practical assumption is made that the behaviour of the chicken bone does not depend on factors such as temperature during irradiation, storage conditions and dose rate. So the aim of the present work was to investigate to what extent the above mentioned factors could influence the post-irradiation dose assessment using the ESR technique. (author).

1996-12-31

274

High-resolution infrared spectroscopy of {gamma}-ray irradiated solid parahydrogen

Short communication.

1992-10-27

275

G2 checkpoint siRNA screen in irradiated cancer cells: validation of candidate positive hits

No abstract prepared.

2002-09-01

276

Norwegian Open Research Archives (NORA)

Full Text Available

277

Food irradiation

Evaluation of transient dose in conveyor type low dose irradiator

A brief article examines the controversy over food irradiation regarding the wholesomeness of irradiated food, its microbiological safety, loss of vitamins and changes in flavour. The benefits of food irradiation are also outlined including the destruction of certain food-borne pathogens and the prolongation of the shelf-life of food by killing pests and delaying the deterioration process. (UK).

1987-02-01

278

Evaluation of performance of antioxidant/antioxidant systems in irradiated natural rubber latex

In conveyor type irradiators, the movement of conveyor and the product boxes is not there until the source is fully in the irradiation position. In case the conveyor system fails the source must automatically be returned to its shielded storage vault. The dose received by the product during the movement of the source from or to the shield becomes significant if the total dose to be received by the product is small. A study has been carried out for evaluating the transient dose received by onions in the POTON irradiator. The results of the study are discussed in this paper. (author)

2003-03-05

279

Effects of MeV ion irradiation on crystallization of amorphous Ge films

Short communication.

1993-02-17

280

Detection of Irradiated Model Food Containing Salt by Thermoluminescence Measurement

Short communication.

1995-12-31

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281

Conclusions from the last five years of experiments in the field of food irradiation in Hungary

Full Text Available

1998-03-01

282

CERAMOGRAPHY ANALYSIS OF MOX FUEL RODS AFTER AN IRRADIATION TEST

AGROSTER Co irradiates food packaging material and some types of spices for the meat industry. The step by step strategy of AGROSTER has been very successful. In the last year, its gamma facility was used as much as possible to irradiate food items. The government of Hungary has recognized the benefit of this technology and has given financial assistance to establish a large commercial gamma irradiator in Budapest.

1988-01-01

283

Antimicrobials in the Management of Post-Irradiation Infection

Full Text Available

2010-10-01

284

Analysis of the relationship between metabolic parameters and the low doses irradiation and non-raditaion factors in humans

... develops. An alternative approach is the use of non-absorbable antibiot- ics such as polymyxin, neomycin, and bacitracin. ...

2011-05-13

285

A mechanism for the degradation of superconducting transition temperatures on high energy neutron irradiation in A-15 compounds

Short communication.

1994-10-25

286

Polymers and paper as packaging materials of irradiated food

Electron microscopic observations of neutron irradiated Nb_3Sn revealed the presence of highly disordered regions of size approximately 35 A in a much less disordered matrix. This observation is shown to provide a means of explaining quantitatively many superconducting properties of irradiated A-15 compounds. In particular Tsub(c) of the irradiated materials could be easily predicted using the mathematical formulations developed for the proximity effect. (Auth.).

287

Observation of the microstructural changes in lithium titanate by multi-ion irradiation

Effects of #gamma#-irradiation on synthetic polymers and paper used as packaging materials for irradiated food have been studied by NMR. Polystyrene, polybutadiene and some copolymers were studied before and after the #gamma#-irradiation treatment and in the presence or absence of antioxidants and stabilisers. In the absence of additives, the effect of #gamma#-irradiation on polystyrene is negligible even irradiating at high doses. In turn, the role of antioxidants and stabilisers is crucial in polybutadiene and butadiene-containing copolymers. Wood pulp paper was also studied by NMR. Preliminary measurements on #gamma#-irradiated wood pulp sheets show a shortening in the T_2 relaxation time component due to the bound water, i.e. some of the bound water is lost. (author)

2000-03-01

288

Observation of the microstructural changes in lithium titanate by multi-ion irradiation

The irradiation behavior of Li{sub 2}TiO{sub 3} under a fusion reactor environment was simulated by simultaneous irradiation of Li{sub 2}TiO{sub 3} by the triple ion beams and the respective single ion beams of O{sup 2+}, He{sup +} and H{sup +}. The microstructural changes in Li{sub 2}TiO{sub 3} caused by the irradiation were measured by Raman spectroscopy and FT-IR photoacoustic spectroscopy. The results suggest that the formation of TiO{sub 2} due to displacements by irradiation occurs, and the irradiation defects generated by irradiation trap hydrogen and increase the amount of hydroxyl near the surface. Such phenomena are believed to significantly affect the chemical form of the released tritium and the tritium inventory in the breeding materials of a fusion reactor.

2004-08-01

289

Lipid composition of liver microsomes and mitochondria after acute and chronic {gamma}-irradiation of rats

The irradiation behavior of Li_2TiO_3 under a fusion reactor environment was simulated by simultaneous irradiation of Li_2TiO_3 by the triple ion beams and the respective single ion beams of O"2"+, He"+ and H"+. The microstructural changes in Li_2TiO_3 caused by the irradiation were measured by Raman spectroscopy and FT-IR photoacoustic spectroscopy. The results suggest that the formation of TiO_2 due to displacements by irradiation occurs, and the irradiation defects generated by irradiation trap hydrogen and increase the amount of hydroxyl near the surface. Such phenomena are believed to significantly affect the chemical form of the released tritium and the tritium inventory in the breeding materials of a fusion reactor.

2004-08-01

290

CANDU 6 fuel behaviour in power ramp conditions

Acute {gamma}-irradiation of rats at doses of 100 and 270 Gy stimulates lipid synthesis and changes the lipid composition of liver cell organelles. The content of cholesterol and cholesterol esters in microsomes increased at 100 Gy and decreased at 270 Gy, with total phospholipid content remaining unchanged. The lipid content in mitochondria decreased considerably 1 h after irradiation at 270 Gy. This change was significantly less pronounced 47 h later. Under chronic {gamma}-irradiation (0.129 Gy/day), cholesterol and cardiolipin in mitochondria increased. The changes in lipid content caused by acute irradiation are presumed to be related to activated synthesis of lipids in the liver. The modification of the lipid content of mitochondria observed in chronically irradiated rats may indicate that energy-metabolizing liver cell systems are involved in the adaptation to ...

1994-07-01

291

Preliminary studies on the detection of irradiated prawns using 2-alkylcyclobutanones

The facilities in the Institute for Nuclear Research at Pitesti allow the testing, handling and examination of nuclear fuel and irradiated materials. The most important facilities are the TRIGA Steady State Research and Material Test Reactor and the Post-Irradiation Examination Laboratory (PIEL). The purpose of this work is to determine by post-irradiation examination, the behavior of CANDU fuel, irradiated in 14 MW TRIGA reactor. The fuel was irradiated in power ramp conditions. The results of post-irradiation examination are: - Visual inspection and photography of the outer appearance of sheath; - Profilometry (diameter, bending, ovality) and length measuring; - Determination of axial and radial distribution of the fusion products activity by gamma scanning and tomography; - Microstructural characterization by metallographic and ceramographic analyzes; - ...

2009-10-12

292

Influence of gamma irradiation and storage on the microbial load, chemical and sensory quality of chicken kabab

The use of ionising radiation for the preservation of food has been under investigation for many years but has yet to receive worldwide acceptance. Although irradiation can be carefully controlled, it is generally accepted that the development of a test or tests for the detection of irradiated food would enhance consumer confidence and might help to enforce labelling regulations. The 2-alkylcyclobutanones are reported to be the only cyclic compounds formed as the products of the radiolysis of saturated and unsaturated triglycerides. The synthesis of 2-dodecylcyclobutanone (DCB) and 2-tetradecylcyclobutanone (TCB), which are formed from palmitic and stearic acid respectively following irradiation, has been carried out and using irradiated chicken meat as the model for a high-lipid containing food, both cyclobutanones have been extracted with hexane and then identified using gas chromatography/mass ...

1996-12-31

293

The design of an irradiator for the continuous processing of liquid latex

Influence of gamma irradiation and storage on the microbial load, chemical and sensory quality of chicken kabab was investigated. Chicken kabab was treated with 0, 2, 4 or 6 kGy doses of gamma irradiation. Treated and untreated samples were kept in a refrigerator (1-4 deg. C). Microbiological, chemical and sensory characteristics of chicken kabab were evaluated at 0-5 months of storage. Gamma irradiation decreased the microbial load and increased the shelf-life of chicken kabab. Irradiation did not influence the major constituents of chicken kabab (moisture, protein and fats). No significant differences (p>0.05) were observed for total acidity between non-irradiated (control) and irradiated chicken kabab. Thiobarbitric acid (TBA) values (expressed as mg malonaldehyde (MDA)/kg chicken kabab) and volatile basic nitrogen (VBN) in chicken kabab were not ...

2010-08-15

294

Structural and magnetic studies on the enhancement of the giant magnetoimpedance by ion irradiation

This paper presents anew design concept for a gamma irradiation plant for the continuous processing of pumpable liquids. Typical applications of such a plant include: the irradiation vulcanisation of natural latex rubber; disinfection of municipal sewage sludge for agricultural use; sterilisation of liquids in the pharmaceutical and cosmetics industries; industrial processing of bulk liquids The authors describe the design and operation of the latex irradiator now operating on a small production scale in Malaysia and proposed developments. The design allows irradiation processing to be carried out under an inert or other gaseous environment. State-of-the-art computer control system ensures the fully automatic processing operation needed by industrial computers.

1998-06-01

295

British Library Electronic Table of Contents (United Kingdom)

The mechanism of abrupt increase of the giant magneto impedance (GMI) ratio in the ion irradiated Co-based amorphous ribbon has been investigated. The grazing incident X-ray diffraction and transmission electron microscope were used to characterize the samples before and after ion irradiation. The GMI-ratio considerably increased in the ion irradiated samples and the GMI response showed strong dependence on the driving frequencies. The Barkhausen noise (BN) signals are increased for the Ar ion irradiated sample with dose of 1x10^1^7 ion/cm^2. The results are interpreted in terms of GMI variation associated with domain wall dynamics.

2011-01-01

296

Neutron irradiation effects in austenitic alloys

Irradiation studies of fusion reactor materials utilizing FFTF/MOTA

The post (neutron) -irradiation high-temperature tensile and creep-rupture properties, deformation and fracture characteristics of austenitic alloys, particularly solution annealed Type 316 steel, are surveyed and correlated with the damage structures developed as a function of irradiation temperature (and dose). The mechanisms proposed to explain the irradiation-induced changes in properties and behaviour are summarised. The factors responsible for the observed differences in the post-irradiation and 'in-reactor' creep-rupture properties and behaviour of an austenitic steel are discussed in terms of the helium gas and stress driven growth of small intergranular bubbles and the atom plating associated with their growth and coalescence. (author).

1980-03-01

297

Induction of sterility in adults of Earias vittella Fabricius through late pupal irradiation

The most important and difficult part of materials research for fusion reactor is realized to be irradiation studies of fusion reactor materials. Irradiation studies of fusion reactor materials utilizing FFTF/MOTA, as one of Japan/U.S.A. Fusion Collaboration Programs, have important role to establish fundamental understanding of heavy irradiation effects on materials behavior and properties and to develop methods and technologies for advanced irradiation studies under fusion reactor environment. This paper briefly reviews the history, the state of the art, and the future of the FFTF/MOTA program. (author).

298

ESR study on the reaction of MMA with the radicals in pre-irradiated wood

Studies on pupal irradiation of Earias vittella Fabricius, were undertaken to determine the optimum dose for sterile and competitive adults. Late pupae were irradiated with gamma radiation doses ranging from 150 to 300 Gy. Emerging adults were normal and without malformation. When males that emerged from irradiated pupae were crossed with normal female, fecundity as well as longevity was comparable to control, but there was drastic reduction in percent egg hatch in all the treatments. However, when females emerging from irradiated pupae were crossed with normal male, there was reduction in the fecundity as well as fertility and this effect was dose dependent. (author).

299

Analysis of o-tyrosine as a method for the identification of irradiated chicken and the comparison with other methods (analysis of volatiles and ESR-spectroscopy)

The nature of radicals in wood irradiated in vacuum was studied by ESR method. The decay rate of radicals changes in three temperature ranges. Long-lived radicals are very stable at 298"0K, at which the wood-plastics composite has often been studied. The number of radicals formed by irradiations shows fairly good agreement with the total number of radicals in each isolated wood component. The graft copolymerization of MMA to irradiated wood was also studied by means of ESR, and it was found that PMMA propagating radicals are formed in irradiated wood. These radicals are probably formed by the result of graft copolymerization of MMA of wood. (auth.).

1975-01-01

300

c-Jun N-terminal Kinase 2 Regulates Multiple Receptor Tyrosine Kinase Pathways in Mouse Mammary Tumor Growth and Metastasis

With the mentioned method to analyse O-tyrosine with HPLC/fluorescence-detection, the irradiation of chicken meat can be determined in a simple and fast way. The formation of o-tyrosine is proportional to the applied dose but because it is also depending on the applied dose rate and the temperature during the irradiation, it is not possible to control the irradiation dose. Since unirradiated chicken can contain little amounts of o-tyrosine and to confirm some results, a second method is needed. Together with one of the other mentioned methods (analysis of the volatiles or esr-spectroscopy) it is possible to recognize irradiated chicken with a high security. (author).

1990-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

Transforming growth factor-? signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung

c-Jun N-terminal kinase 2 (JNK2) isoforms are transcribed from the jnk2 gene and are highly homologous with jnk1 and jnk3 transcriptional products....Full Text Available

2011-01-01

302

Tissue tropism and neuroinvasion of West Nile virus do not differ for two mouse strains with different survival rates

Hypoxia causes abnormal neonatal pulmonary artery remodeling (PAR) and inhibition of alveolar development (IAD). Transforming growth factor (TGF)-β is an important regulator of lung development...Full Text Available

2008-07-01

303

Targeted suppression of Has2 mRNA in mouse cumulus cell-oocyte complexes by adenovirus-mediated short-hairpin RNA expression

West Nile virus (WNV) is a mosquito-borne flavivirus that infects the central nervous system of humans and other animals. In this study, we found that C3H/HeN (C3H) mice exhibited a higher morbidity...Full Text Available

2007-11-25

304

Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

RNA interference (RNAi) is an effective tool for studying gene function in oocytes, but no studies have targeted somatic cells of primary cultured cumulus cell-oocyte complexes (COCs). This...Full Text Available

2009-06-01

305

Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines as EGFR and ErbB-2 inhibitors

The management of CNS tumors is limited by the blood-brain barrier (BBB), a vascular interface that restricts the passage of most molecules from the blood into the brain. Here we show that phage particles...Full Text Available

2011-01-04

306

British Library Electronic Table of Contents (United Kingdom)

A novel class of pyrrolidinyl-acetyleneic thieno[3,2-d]pyrimidines has been identified which potently inhibit the EGFR and ErbB-2 receptor tyrosine kinases. Synthetic modifications of the pyrrolidine carbamate moiety result in a range of effects on enzyme and cellular potency. In addition, the impact of the absolute stereochemical configuration on cellular potency and oral mouse pharmacokinetics is described.

2009-01-01

307

Studies with 1,2-dithiole-3-thione as a chemoprotector of hydroquinone-induced toxicity to DBA/2-derived bone marrow stromal cells.

Stearoyl-Coenzyme A Desaturase 1 Deficiency Protects against Hypertriglyceridemia and Increases Plasma High-Density Lipoprotein Cholesterol Induced by Liver X Receptor Activation

Stromal cells from DBA/2 mouse bone marrow have been shown to be susceptible to cytotoxicity induced by several redox-active metabolites of benzene, including hydroquinone (HQ). Treatment with HQ also...Full Text Available

1993-06-01

308

Multistage skin tumor promotion: involvement of a protein kinase

Stearoyl-coenzyme A desaturase (SCD) is the rate-limiting enzyme necessary for the biosynthesis of monounsaturated fatty acids. In this study, we investigated the regulation of mouse SCD1 by liver X...Full Text Available

2006-09-01

309

Feynman diagram drawing made easy

Current information suggests that chemical carcinogenesis is a multistep process with one of the best studied models in this regard being the two-stage carcinogenesis system using mouse skin. The effects of several carcinogens and tumor promoters in various sequences of application were studied to examine the nature of the process. The actions of several tumor inhibitors were compared. (ACR)

1980-01-01

310

Effects of Chronic JP-8 Jet Fuel Exposure on Lung Function.

We present a drawing package optimised for Feynman diagrams. These can be constructed interactively with a mouse-driven graphical interface or from a script file, more suitable to work with a diagram generator. It provides most features encountered in Feynman diagrams and allows to modify every part of a diagram after its creation. Special attention has been paid to obtain a high quality printout as easily as possible. This package is written in Tcl/Tk and in C. (orig.).

311

Cordycepin Blocks Lung Injury-Associated Inflammation and Promotes BRCA1-Deficient Breast Cancer Cell Killing by Effectively Inhibiting PARP

The past three years of work for the Air Force Office of Scientific Research has resulted in the development of a congenic mouse model of JP-8 jet fuel exposure, the role of substance P in the JP-8 jet fuel-induced lung injury process, and development of ...

1997-01-01

312

Cellular DNA region involved in induction of thymic lymphomas (Mlvi-2) maps to mouse chromosome 15.

Cordycepin has been shown to interfere with a myriad of molecular processes from RNA elongation to kinase activity, and prevents numerous inflammatory processes in animal models. Here we show in a mouse...Full Text Available

2011-09-01

313

A comparison of x-ray detectors for mouse CT imaging

Two cellular DNA regions representing common domains for proviral DNA integration ( Mlvi -1 and Mlvi -2) have been identified in Moloney murine leukemia virus-induced rat thymic lymphomas. Cellular...Full Text Available

1984-05-01

314

A System-Based Comparison of Gene Expression Reveals Alterations in Oxidative Stress, Disruption of Ubiquitin-Proteasome System and Altered Cell Cycle Regulation after Exposure to Cadmium and Methylmercury in Mouse Embryonic Fibroblast

There is significant interest in using computed tomography (CT) for in vivo imaging applications in mouse models of disease. Most commercially available mouse x-ray CT scanners utilize a charge-coupled device (CCD) detector coupled via fibre optic taper to a phosphor screen. However, there has been little research to determine if this is the optimum detector for the specific task of in vivo mouse imaging. To investigate this issue, we have evaluated four detectors, including an amorphous selenium (a-Se) detector, an amorphous silicon (a-Si) detector with a gadolinium oxysulphide (GOS) screen, a CCD with a 3:1 fibre taper and a GOS screen, and a CCD with a 2:1 fibre taper and both GOS and thallium-doped caesium iodide (CsI:Tl) screens. The detectors were evaluated by measuring the modulation transfer function (MTF), noise power spectrum (NPS), detective quantum efficiency (DQE), stability over multiple exposures, and noise ...

2004-12-07

315

4.5S RNA is encoded by hundreds of tandemly linked genes, has a short half-life, and is hydrogen bonded in vivo to poly(A)-terminated RNAs in the cytoplasm of cultured mouse cells.

Environmental and occupational exposures to heavy metals such as methylmercury (MeHg) and cadmium (Cd) pose significant health risks to humans, including neurotoxicity. The underlying mechanisms of...Full Text Available

2010-04-01

316

Ultraviolet upconversion luminescence enhancement in Yb3+/Er3+-codoped Y2O3 nanocrystals induced by tridoping with Li+ ions

4.5S RNA is a group of RNAs 90 to 94 nucleotides long (length polymorphism due to a varying number of UMP residues at the 3' end) that form hydrogen bonds with poly(A)-terminated RNAs isolated from...Full Text Available

1986-05-01

317

Ultraviolet radiation in Finland

Ultraviolet (UV) upconversion (UC) luminescence in Yb3+/Er3+-codoped yttrium oxide (Y2O3) nanocrystals can be enhanced by orders of magnitude via tridoping further with Li+ ions under diode laser excitation of 970 nm. Sensitized three-photon UC radiations at 390 and 409 nm, corresponding to the 4G11/2?4I15/2 and 4H9/2?4I15/2 of Er3+ ions, respectively, present an enhancement time of about 33 times, which is larger than the 24 times enhancement for the UC green radiation. The UV UC radiation at 320 nm that corresponds to the 2P3/2?4I15/2 of Er3+ ions has also been greatly enhanced. Theoretical calculations interpret that all the observed enhancement times of UV UC radiations arise from the prolonged lifetimes of their intermediate states.

2009-03-01

318

Space nuclear power requirements for ozone layer modification

Solar ultraviolet radiation is damaging for living organisms due to its high energy pro each photon. The UV radiation is often separated into three regions according to the wavelength: UVC (200-280 nm), UVB (280-320 nm) and UVA (320-400 nm). The most hazardous part, UVC is absorbed completely in the upper atmosphere by molecular oxygen. UVB radiation is absorbed by atmospheric ozone partly, and it is reaching Earth`s surface, as UVA radiation. Besides atmospheric ozone, very important factors in determining the intensity of UVB radiation globally are the solar zenith angle and cloudiness. It may be calculated from global ozone changes that the clear-sky UVB doses may have enhanced by 10-15 % during spring and 5-10 % during summer at the latitudes of Finland, following the decrease of total ozone between 1979-90. The Finnish ozone and UV monitoring activities have become a part of international activities, especially the EU Environment and Climate Programme`s ...

1996-12-31

319

Second Byurakan spectral sky survey. II. Results for region centered on alpha 09h50m, delta +55 deg 00 arcmin

This work estimates the power requirements for using photochemical processes driven by space nuclear power to counteract the Earth's ozone layer depletion. The total quantity of ozone (O_3) in the Earth's atmosphere is estimated to be about 4.7 x 10"3"7 molecules. The ozone production and destruction rates in the stratosphere are both on the order of 4.9 x 10"3"1 molecules/s, differing by a small fraction so that the net depletion rate is about 0.16 to 0.26% per year. The delivered optical power requirement for offsetting this depletion is estimated to be on the order of 3 GW. If the power were produced by satellite reactors at 800 km altitude (orbit decay time #approx# 300 years), some means of efficient power beaming would be needed to deliver the power to stratospheric levels (10--50 km). Ultraviolet radiation at 140--150 nm could have higher absorption rates in O_2 (leading to production of atomic oxygen, which can combine with O_2 to form O_3) than in ozone ...

1992-01-13

320

Photobiological activity of marmesin (5-B-hydroxyisopropyl-4-5 dihydrofurocoumarin) in Chinese hamster V79 cells

The second list of objects in the Second Biurakan Spectral Sky Survey of the region centered on alpha 09h50m, delta +55 deg 00 arcmin is given. The list contains data on 110 objects and galaxies of a peculiar physical nature and 24 blue stars. The observations were made with the 40-52 arcsec Schmidt telescope of the Biurakan Astrophysical Observatory with a set of three objective prisms using Kodak IIIaJ and IIIaF emulsions sensitized in nitrogen. The area is found to contain 20 quasar candidates and four Seyfert galaxies, 27 blue stellar objects, 24 galaxies with an appreciable ultraviolet continuum, and 39 emission galaxies without appreciable ultraviolet radiation. The surface brightness of the quasars and Seyferts on the considered area down to the limiting magnitude 19.5 M is more than 1.5 per square degree with allowance for the already known quasars. The surface density of emission galaxies is about four per square degree. 7 references.

1984-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

Observation of the Far-ultraviolet Continuum Background with SPEAR/FIMS

Marmesin was isolated from the medicinal plant, Afraegle paniculata. Its cytotoxicity and mutagenicity in Chinese hamster V79 cells when sensitized to near ultraviolet (NUV) and long wavelength ultraviolet light or black light (BL) were assayed. Marmesin was extremely cytotoxic in the dark. This cytotoxicity was photoenhanced in NUV and BL; the photoenhanced lethality being higher in NUV than in BL. The LD/sub 50/ of marmesin under NUV and BL photosensitization were 0.002 ..mu..M and (0.012 ..mu..M), respectively. In the absence of NUV and BL, marmesin's LD/sub 50/ was 0.013 ..mu..M.NUV and BL without marmesin were not significantly cytotoxic at the fluence rates of 0.29 W/m/sup 2/ and 4.2 W/m/sup 2/, respectively, for up to 20 min. In contrast to the observed high cytotoxicity of marmesin, its mutagenicity at the HGPRT locus (Asub(z)Gsup(r)) was weak. The implication of this result in the high incidence of skin cancer in Nigeria in ...

1983-10-01

322

Multilayer reflective coatings for extreme-ultraviolet lithography

We present the general properties of the far-ultraviolet (FUV; 1370-1720A) continuum background over most of the sky, obtained with the Spectroscopy of Plasma Evolution from Astrophysical Radiation instrument (SPEAR, also known as FIMS), flown aboard the STSAT-1 satellite mission. We find that the diffuse FUV continuum intensity is well correlated with N_{HI}, 100 $\\mu$m, and H-alpha intensities but anti-correlated with soft X-ray. The strongest correlation is with the H-alpha emission, and the correlation of the diffuse background with the direct stellar flux is weaker than the correlation with other parameters. The continuum spectra are relatively flat. However, a weak softening of the FUV spectra toward some sight lines, mostly at high Galactic latitudes, is found not only in direct-stellar but also in diffuse background spectra. The diffuse background is relatively softer that the direct stellar spectrum. We also find that the diffuse FUV background averaged ...

2010-01-01

323

Mitochondrial genetic damage induced in yeast by a photoactivated furocoumarin in combination with ethidium bromide or ultraviolet light

Multilayer mirror coatings which reflect extreme ultraviolet (EUV) radiation are a key enabling technology for EUV lithography. Mo/Si multilayers with reflectances of 67.5% at 13.4 nm are now routinely achieved and reflectances of 70 2% at 11.4 nm were obtained with MO/Be multilayers. High reflectance is achieved with careful control of substrate quality, layer thicknesses, multilayer materials, interface quality, and surface termination. Reflectance and film stress were found to be stable relative to the requirements for application to EUV lithography. The run-to-run reproducibility of the reflectance peak position was characterized to be better than 0.2%, providing the required wavelength matching among the seven multilayer-coated mirrors used in the present lithography system design. Uniformity of coating was improved to better than 0.5% across 150 mm diameter substrates. These improvements in EUV multilayer mirror technology will enable us to meet the stringent ...

1998-03-10

324

Low-temperature synthesis and room temperature ultraviolet lasing of nanocrystalline ZnO films

Ethidium bromide (EB) and ultraviolet light (UV) in combination are known to produce a synergistic induction of 'petite' mutants in yeast. Two other agents were combined with EB, 3-Carbethoxypsoralene (3 CPs) activated by 365 nm light or #gamma# rays. EB in combination with 3 CPs also resulted in an enhanced production of 'petite' mutants. After the photoaddition of 3 CPs in exponential phase cells, recovery of the 'petite' mutation during dark liquid holding was inhibited by the presence of EB producing an enhanced number of 'petite' mutants. The behavior of mitochondrial antibiotic resistance markers after individual and combined treatments with EB and 3 CPs indicates a random loss of markers after EB and a preferential loss of a certain region for the 3 CPs photoaddition. The combination of the two agents leads to an additivity of total drug marker losses rather than a synergistic loss. The combination of EB with #gamma# rays produced no enhancement in 'petite' ...

325

FT-IR spectroscopic studies of polycyclic aromatic hydrocarbons

Nanocrystalline ZnO films were fabricated via a simple method involving the oxidation of Zn films at a remarkably low temperature of 380 C. X-ray diffraction study confirmed that the Zn films were completely oxidized even at the low temperature of 380 C and the ZnO films fabricated were of polycrystalline wurtzite structure. Room temperature optical pumping using a frequency-quintupled Q-switched Nd:YAG laser ({lambda}=213 nm) exhibited that sharp peaks at around 3.12 eV emerged above excitation powers of {proportional_to}7 MW/cm{sup 2}, demonstrating lasing in the ZnO films. These results represent that the process is a simple, promising approach for fabricating ZnO of sufficient optical performance for use as ultraviolet (UV) light emitters and an alternative UV laser source; both are key components in short-wavelength photonic devices. (orig.)

2005-02-01

326

Detection of H2 Emission from Mira B in UV Spectra from the Hubble Space Telescope

Proper assessment of the hypothesis which correlates polycyclic aromatic hydrocarbons (PAHs) with the unidentified infrared emission bands requires additional experimental laboratory data. In order to address this need, thermal infrared emission studies were performed on a subset of PAHs suggested to be of astrophysical importance. It was proposed that infrared emission from interstellar PAHs occurs following absorption of an ultraviolet photon. Since energy transfer to the ground electronic state can be rapid for a species in which intersystem crossing is negligible, the emission spectrum may be viewed as resulting from an equilibrium vibrational temperature (Leger and d'Hendecourt, 1987). This has been the basis for using infrared absorption spectra to calculate the corresponding emission spectra at various temperatures. These calculations were made using room temperature infrared absorption coefficients instead of those at the temperature of interest because of ...

1990-04-01

327

The radiation hardening and microstructural defect evolution in ion irradiated Fe-Cr alloys with irradiation temperature

We present ultraviolet spectra of Mira's companion star from the Space Telescope Imaging Spectrograph (STIS) instrument on board the Hubble Space Telescope (HST). The companion is generally assumed to be a white dwarf surrounded by an accretion disk fed by Mira's wind, which dominates the UV emission from the system. The STIS UV spectrum is dominated by numerous, narrow H2 lines fluoresced by H I Ly-alpha, which were not detected in any of the numerous observations of Mira B by the International Ultraviolet Explorer (IUE). The high temperature lines detected by IUE (e.g., C IV 1550) still exist in the STIS spectrum but with dramatically lower fluxes. The continuum fluxes in the STIS spectra are also much lower, being more than an order of magnitude lower than ever observed by IUE, and also an order of magnitude lower than fluxes observed in more recent HST Faint Object Camera objective prism spectra from 1995. Thus, the accretion rate onto Mira ...

2001-01-01

328

The dependence of radiation hardening and embrittlement on irradiation temperature

Generally, neutron, ion and electron Irradiations cause a substantial amount of hardening and significantly alter the deformation behavior of metals and alloys at relatively low irradiation temperatures. A radiation hardening is caused by the formation of microstructural defects such as dislocation loops, voids and precipitates under irradiation. Therefore, it is important to have a better knowledge of the irradiation induced microstructural defects under irradiation condition. As a part of the National mid- and long-term atomic energy R and D program, we are dealing with the radiation hardening behavior in Fe-Cr binary alloy. Fe-Cr binary alloy is a base alloy of Ferritic/Martensitic steel(F/M steel) planning to use for the Gen IV nuclear system. In this work, we investigated the radiation hardening and microstructural defect evolution in ion irradiated Fe-Cr ...

2009-05-01

329

The application of irradiation techniques for food preservation and processing improvement

Assessments of the hardening and embrittlement of pressure vessel steels and welds as a function of neutron dose use trend curves derived from surveillance programs and accelerated irradiation data. A temperature dependent factor is incorporated for assessing vessel locations operating at different temperatures. As hardening and embrittlement arise from the sum of matrix damage and copper impurity precipitation, the influence of irradiation temperature on each process needs to be established. For irradiations performed below #approx# 300 C recent data shows that the dose-dependent growth of copper precipitates ceases at a mean diameter of about 2 nm that also corresponds to peak hardening and embrittlement by copper. For doses beyond this peak copper dose the property-dependence on irradiation temperature can be identified with that of matrix damage alone. An analysis of several experiments on plate ...

1994-06-20

330

Study on the variations of molecular structures of some biomolecules induced by free electron laser using FTIR spectroscopy

This project has intended to develop alternative techniques to be used in food industry for food processing and utilization by safe irradiation methods. For improvement of rheology and processing in corn starch by irradiation, the production of modified starch with low viscosity as well as with excellent viscosity stability became feasible by the control of gamma irradiation dose levels and the amount of added inorganic peroxides to starch. Also, this project was developed the improvement methods of hygienic quality and long-term storage of dried red pepper by gamma irradiation. And, in Korean medicinal plants, 10 kGy gamma irradiation was effective for improving sanitary quality and increasing extraction yield of major components. For the sanitization of health and convenience foods, gamma irradiation was more effective than ozone treatment in decontamination ...

1997-09-01

331

Radiation resistance of nylon. [Gamma radiation

In this study, free electron laser (FEL) with selective wavelength was used to induce structure changes of biomolecules, which were characterized by FTIR spectroscopy. For understanding of the interactions between FEL and biomolecules as well as biological tissues, the biomolecules investigated are ATP, ADP, AMP, t-RNA, D-ribose and the complex of SmCl_3-D-ribose. Their FTIR spectra before and after irradiation of FEL show molecular structure variations of the samples after irradiation of FEL, especially the rearrangement of their hydrogen bond networks. Along with the various irradiation wavelengths, irradiation time and molecular structures, the changes after irradiation are different for these molecules. In the FTIR spectra after irradiation, the phenomenon that the bands split into several peaks indicates the existence of several structures, conformations ...

2007-05-01

332

Effects of ionizing radiation on properties of monolayer and multilayer flexible food packaging materials

Various nylons including nylon 6, nylon 66, nylon 610 and nylon 12 in the forms of fiber and film were irradiated with the gamma-ray from Co-60 at the dose rate of 0.12 Mrad/hr in the atmosphere of oxygen at 7 kg/cm/sup 2/ and at the room temperature. The irradiation in vacuum on the same specimens was performed at 0.5 Mrad/hr. The tensile properties and the gel fraction of the irradiated nylon samples were measured, and the radiation resistance of the nylons against the irradiation at low dose rate was estimated. From the experimental results, it became clear that in the case of irradiation in vacuum, all the nylons were durable to the irradiation of 250 Mrad or more, and nylon 6 was more durable than nylon 12, and in the case of irradiation in pressurized oxygen, the radiation resistance of the nylons decreased to one-tenth as compared ...

1983-12-01

333

Effect of gamma irradiation on the antimicrobial and free radical scavenging activities of Glycyrrhiza glabra root

Volatile compounds produced in flexible food packaging materials (LDPE, EVAc, PET/PE/EVOH/PE) during electron beam irradiation were isolated by purge and trap technique and identified by combined gas chromatography-mass spectrometry (GC/MS), after thermal desorption and concentration. For comparison purposes non-irradiated films were also studied. Film samples were irradiated at low (5 kGy, corresponding to cold pasteurization), intermediate (20 kGy, corresponding to cold sterilization) and high (100 kGy) doses. It was observed that a number of volatile compounds are produced after irradiation in all cases. Furthermore the amounts of all volatile compounds increase with increasing irradiation dose. Both primary (methyl-derivatives etc.) as well as secondary i.e. oxidation products (ketones, aldehydes, alcohols, carboxylic acids etc.) are produced upon ...

1999-05-01

334

Vibrational Circular Dichroism: A developing spectroscopic technique for peptide and protein conformational studies

The efficacy of gamma irradiation as a method of decontamination for food and herbal materials is well established. In the present study, Glycyrrhiza glabra roots were irradiated at doses 5, 10, 15, 20 and 25 kGy in a cobalt-60 irradiator. The irradiated and un-irradiated control samples were evaluated for phenolic contents, antimicrobial activities and DPPH scavenging properties. The result of the present study showed that radiation treatment up to 20 kGy does not affect the antifungal and antibacterial activity of the plant. While sample irradiated at 25 kGy does showed changes in the antibacterial activity against some selected pathogens. No significant differences in the phenolic contents were observed for control and samples irradiated at 5, 10 and 15 kGy radiation doses. However, phenolic contents increased in samples treated with 20 ...

2010-04-01

335

Ultraviolet Complete Electroweak Model Without a Higgs Particle

Electronic circular dichroism (ECD) of the n-#pi# and #pi# -#pi# transitions of the amide groups in the ultraviolet has become an indispensable tool for qualitative characterization of proteins in solution. Since the existence of such a spectrum (that is, of natural optical activity) comes from the three dimensional interaction of the chromophores in the molecule, CD is exquisitely sensitive to molecular conformation. However, in proteins, the amide transitions available in the near UV are limited in number and are broads and overlapping. Interactions among them yield information about the polymeric backbone, but since such amide electronic excitation are relatively delocalized, the resulting

1996-11-01

336

Two-Loop Virtual Corrections to Drell-Yan Production at order alpha_s alpha^3

An electroweak model with running coupling constants described by an energy dependent entire function is utraviolet complete and avoids unitarity violations for energies above 1 TeV. The action contains no physical scalar fields and no Higgs particle and the physical electroweak model fields are local and satisfy microcausality. The $W$ and $Z$ masses are compatible with a symmetry breaking $SU(2)_L\\times U(1)_Y \\rightarrow U(1)_{\\rm em}$, which retains a massless photon. The vertex couplings possess an energy scale $\\Lambda_W > 1$ TeV predicting scattering amplitudes that can be tested at the LHC.

2010-01-01

337

Tunable VUV generation by anti-Stokes stimulated Raman conversion of XeCl laser radiation

The Drell-Yan mechanism for the production of lepton pairs is one of the most basic processes for physics studies at hadron colliders. It is therefore important to have accurate theoretical predictions. In this work we compute the two-loop virtual mixed QCD x QED corrections to Drell-Yan production. We evaluate the Feynman diagrams by decomposing the amplitudes into a set of known master integrals and their coefficients, which allows us to derive an analytical result. We also perform a detailed study of the ultraviolet and infrared structure of the two-loop amplitude and the corresponding poles in epsilon.

2011-01-01

338

Photoluminescence and cathodoluminescence properties of Tb3+ activated Sr3AlO4F emitting-color tunable phosphor

This paper reports on the results of experiments into efficient higher-order anti-Stokes Raman conversion of tunable short-pulse XeCl laser radiation. The maximum output energy of the pumping laser, in which the radiation of a frequency-doubled dye laser is amplified by two XeCl laser amplifiers, is 55 mJ with a pulse duration of 1 ns FWHM. Using hydrogen gas as a Raman medium, a series of anti-Stokes lines up to the 12th order (121.5 nm) is generated in the vacuum ultraviolet (VUV) region. 16 references.

1987-06-01

339

British Library Electronic Table of Contents (United Kingdom)

Tb3+-activated Sr3AlO4F phosphors were synthesized by a high-temperature solid-state reaction method. The investigation of photoluminescence and cathodoluminescence indicates that these phosphors can be effectively excited by ultraviolet light and low-voltage electron beam. The phosphors exhibit a tunable-green emission. The luminescence behaviors are explained by the site occupancy of Tb3+ ions in the host crystal and the cross-relaxation of 5D3 to 5D4 state.

2011-01-01

340

Photoluminescence and cathodoluminescence properties of Tb3+ activated Sr3AlO4F emitting-color tunable phosphor

Photochemical generation of E' centre from Si-H in amorphous SiO2 under pulsed ultraviolet laser radiation

Tb3+-activated Sr3AlO4F phosphors were synthesized by a high-temperature solid-state reaction method. The investigation of photoluminescence and cathodoluminescence indicates that these phosphors can be effectively excited by ultraviolet light and low-voltage electron beam. The phosphors exhibit a tunable-green emission. The luminescence behaviors are explained by the site occupancy of Tb3+ ions in the host crystal and the cross-relaxation of 5D3 to 5D4 state.

2011-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

Partial inhibition of in vitro pollen germination by simulated solar ultraviolet-B radiation

In situ optical absorption spectroscopy was used to study the generation of E' centres in amorphous SiO_2 occurring by photo-induced breaking of Si-H groups under 4.7eV pulsed laser radiation. The dependence from laser intensity of the defect generation rate is consistent with a two-photon mechanism for Si-H rupture, while the growth and the saturation of the defects are conditioned by their concurrent annealing due to reaction with mobile hydrogen arising from the same precursor. A rate equation is proposed to model the kinetics of the defects and tested on experimental data.

2006-01-01

342

Optimum plasma conditions for the efficient high-order harmonic generation in platinum plasma

Pollen from four temperate-latitude taxa were treated with UV radiation in a portion of the UV-B (280-320 nm) waveband during in vitro germination. Inhibition of germination was noted in this pollen compared to samples treated identically except for the exclusion of the UV-B portion of the spectrum. Levels similar to maximum solar UV-B found in temperate-latitude areas failed to inhibit pollen germination significantly, while levels similar to maximum solar UV-B found in equatorial alpine locations caused partial inhibition of germination in three of the four taxa examined.

1984-01-01

343

Lasing below 200 nm in the NIJI-IV compact storage-ring-based free electron laser

We studied the optimum plasma conditions that are required for efficient high-order harmonic generation in platinum plume. Harmonics up to the 49th order (?=16.32 nm) are analyzed under various conditions of laser-plasma interaction. Time-resolved ultraviolet spectra of platinum plasma at both optimum and nonoptimum conditions of harmonic generation are presented. We calculated the ionization states of the plasma, free electron density, and singly charged ion density at different prepulse intensities and compared them with experimental results.

2007-06-01

344

Endomicroscopy imaging of epithelial structures using tissue autofluorescence

Laser gain of the NIJI-IV compact storage-ring-based Free Electron Laser (FEL) system at AIST reached #approx#9% at 200 nm for an average beam current of 16.3 mA. In addition to such a drastic gain enhancement, improvement of the laser-cavity performance has led to successful FEL lasing in the vacuum ultraviolet below 200 nm even in a compact system. Temporal and spectral characteristics of the NIJI-IV FEL were examined around 200 nm. FEL performance will be briefly discussed from the application point of view.

2004-08-01

345

Emission Line Spectra in the Soft X-Ray Region 20-75 (Angstrom)

We explore autofluorescence endomicroscopy as a potential tool for real-time visualization of epithelial tissue microstructure and organization in a clinical setting. The design parameters are explored using two experimental systems--an Olympus Medical Systems Corp. stand-alone clinical prototype probe, and a custom built bench-top rigid fiber conduit prototype. Both systems entail ultraviolet excitation at 266 nm and/or 325 nm using compact laser sources. Preliminary results using ex vivo animal and human tissue specimens suggest that this technology can be translated toward in vivo application to address the need for real-time histology.

2011-04-01

346

Development of detection methods for irradiated foods; development of immunological identification of irradiated foods

As part of a project to complete a comprehensive catalogue of astrophysically relevant emission lines in support of new-generation X-ray observatories using the Lawrence Livermore electron beam ion traps EBIT-I and EBIT-II, we studied emission lines of argon and sulfur in the soft X-ray and extreme ultraviolet region. Here we present observations of Ar IX through Ar XVI and S VII through S XIV between 20 and 75 {angstrom} to illustrate our work.

2002-06-18

347

FORMATION EPOCHS, STAR FORMATION HISTORIES, AND SIZES OF MASSIVE EARLY-TYPE GALAXIES IN CLUSTER AND FIELD ENVIRONMENTS AT z = 1.2: INSIGHTS FROM THE REST-FRAME ULTRAVIOLET

Enzyme-linked Immunosorbent assay systems for the identification of irradiated egg, pork and chicken was developed. Eggs were irradiated in their shells to 0.5{approx}7kGy. Pork was irradiated to 0.5{approx}3kGy and chicken irradiated to 0.5kGy{approx}5kGy. The most sensitive proteins to irradiation were screened by SDS-PAGE and purified. Ovalbumin from egg, salt soluble protein(p) from pork, and salt soluble protein(c) from chicken showed the most sensitivity to irradiation. To investigate for a practical use in identifying of irradiated egg, pork and chicken, competitive ELISA was performed. The binding activity of ovalbumin to anti-ovalbumin IgG was reduced in a dose-dependent manner by irradiating up to 7kGy, and considerably lowered after irradiating at 7kGy. The concentration of 50% inhibition ...

2002-04-01

348

Transmutation of americium in fission reactors

We derive stellar masses, ages, and star formation histories (SFHs) of massive early-type galaxies in the z = 1.237 RDCS1252.9-2927 cluster and compare them with those measured in a similarly mass-selected sample of field contemporaries drawn from the Great Observatories Origin Deep Survey South Field. Robust estimates of these parameters are obtained by comparing a large grid of composite stellar population models with 8-9 band photometry in the rest-frame near-ultraviolet, optical, and IR, thus sampling the entire relevant domain of emission of the different stellar populations. Additionally, we present new, deep U-band photometry of both fields, giving access to the critical far-ultraviolet rest frame, in order to empirically constrain the dependence of the most recent star formation processes on the environment. We also analyze the morphological properties of both samples to examine the dependence of their scaling relations on their mass ...

2010-01-20

349

Transmutation of americium in fission reactors

To get a considerable reduction of the radiotoxicity due to americium, a thermal neutron fluence of 2.10{sup 22} cm{sup -2} or a fast neutron fluence of 2.10{sup 24} cm{sup -2} is required. Irradiation in a thermal neutron flux leads to lower masses of {sup 234}U and precursors and of {sup 237}Np and precursors, but to higher curium masses and much higher neutron emission rates than irradiation in a fast neutron flux. Therefore, irradiation in a fast neutron flux has preference when multiple recycling is adopted. When once-through burning is applied, irradiation in a thermal neutron flux can be applied. Then irradiation in a heavy water reactor (HWR) has preference above irradiation in a PWR or in a high temperature gas-cooled reactor (HTGR). (authors) 4 refs.

1995-12-31

350

Studies on application of radiation and radioisotopes -The application of irradiation techniques for food preservation and process improvement-

To get a considerable reduction of the radiotoxicity due to americium, a thermal neutron fluence of 2.10{sup 22} cm{sup -2} or a fast neutron fluence of 2.10{sup 24} cm{sup -2} is required. Irradiation in a thermal neutron flux leads to lower masses of {sup 234}U and precursors and of {sup 237}Np and precursors, but to higher curium masses and much higher neutron emission rates than irradiation in a fast neutron flux. Therefore, irradiation in a fast neutron flux has preference when multiple recycling is adopted. When once-through burning is applied, irradiation in a thermal neutron flux can be applied. Then irradiation in a HWR has preference above irradiation in a PWR or in a HTGR. (orig.).

1995-06-01

351

Radiolysis compounds in bacon and chicken. Final report 18 Sep 81-20 Sep 82

The project was designed to solve the infra structural problem required for commercialization of food irradiation. In improvement of physical properties of corn starch, gamma irradiation was effective for increasing glucose productivity and for substituting traditional modified starches (acid modified starch, oxidized starch). In immobilization of microorganisms, the mass production method of natural red pigment was developed by using immobilized mold pellets. In Korean medicinal plants, 10 kGy gamma irradiation was effective for improving sanitary quality and increasing extraction yield. In evaluation of wholesomeness, gamma irradiated red ginseng could be safe on the genotoxic point of view. And also, six items of irradiated foods approved for human consumption from Korea ministry of health and welfare in May 19, 1995. 30 figs, 20 tabs, 54 refs. (Author).

1995-07-01

352

Photoluminescence Decay of Irradiated Herbs

The results of this study are in agreement with the precepts established in studies published previously on beef, chicken, ham, and pork. The radiolysis compounds from bacon, chicken, ham, and pork are comparable in identity and amounts to those found in irradiated beef for comparable compositions and irradiation parameters (temperature, dose, etc.). The results of this study support the conclusions drawn in the CORC report of 'commonality in chemistry, predictability of products, and extrapolation of results.' Consequently, the same conclusions can be drawn concerning the wholesomeness of irradiated bacon, chicken, ham, and pork as for other irradiated meat products of similar composition and irradiation parameters as reported in the FASEB report and its supplements (I and II) on irradiated beef.

1984-01-01

353

Photoluminescence Decay of Irradiated Herbs

Thermoluminescence of inorganic dust extract from herbs and spices has been demonstrated to be a useful method to discriminate irradiated food products as well as to estimate the total dose exposure. The time evolution of infrared stimulated luminescence has been systematically investigated in potassium feldspar and albite minerals subjected to different doses of gamma irradiation (ranging from 0 to 8 kGy). Experimental results reveal a 300-600 nm signal which is greatly intensified for irradiated samples, following the same irradiation dose dependence observed in thermoluminescence. The luminescence intensity disappears after few seconds of illumination, following a time evolution which is proportional to (1 + Bt){sup -P}. The influence of both B and P factors upon the irradiation dose has been systematically analysed. (author)

1999-07-01

354

Issues in food irradiation

Thermoluminescence of inorganic dust extract from herbs and spices has been demonstrated to be a useful method to discriminate irradiated food products as well as to estimate the total dose exposure. The time evolution of infrared stimulated luminescence has been systematically investigated in potassium feldspar and albite minerals subjected to different doses of gamma irradiation (ranging from 0 to 8 kGy). Experimental results reveal a 300-600 nm signal which is greatly intensified for irradiated samples, following the same irradiation dose dependence observed in thermoluminescence. The luminescence intensity disappears after few seconds of illumination, following a time evolution which is proportional to (1 + Bt)"-"P. The influence of both B and P factors upon the irradiation dose has been systematically analysed. (author)

1998-07-05

355

High energy heavy ion irradiation in semiconductors

This discussion paper has two goals: first, to raise public awareness of food irradiation, an emerging technology in which Canada has the potential to build a new industry, mainly oriented to promising overseas markets; and second, to help build consensus among government and private sector decision makers about what has to be done to realize the domestic and export potential. The following pages discuss the potential of food irradiation; indicate how food is irradiated; outline the uses of food irradiation; examine questions of the safety of the equipment and both the safety and nutritional value of irradiated food; look at international commercial developments; assess the current and emerging domestic scene; and finally, draw some conclusions and offer suggestions for action.

1995-10-01

356

Gamma irradiation induced damage creation on the cation distribution, structural and magnetic properties in Ni-Zn ferrite

Pd/n-Si and Pd/n-GaAs devices have been irradiated from high energy ({approx}100 MeV) heavy ions of Au{sup 7+} (gold) and Si{sup 7+} (silicon) to study the irradiation effects in these junction devices on semiconductor substrates. The devices have been characterized from I-V and C-V studies for electronic flow characterization. It has been found that the devices become high resistive on the irradiation and the substrates change the conductivity type from n- to p- on the irradiation of fluence of {approx}10{sup 12}-10{sup 13} ions/cm{sup 2}. The change in conductivity type has been understood as a result of creation of deep acceptors on the irradiation.

1999-07-02

357

Effect of local irradiation on longitudinal bone growth in the rat. A tetracycline labelling investigation

Ferrite of system, namely Ni_1_-_xZn_xFe_2O_4 with x = (0.0, 0.2, 0.4, 0.6, 0.8, 1.0), have been prepared by solid state reaction to investigate the effect of gamma rays irradiations using Co"6"0 source on the cation distribution, structural and magnetic properties. The unirradiated and irradiated samples were then subjected to characterization techniques such as X-ray diffraction, magnetization and AC susceptibility. The results of these characterizations are found to be different for irradiated from that of the pristine sample. The modifications in respect of irradiated samples are explained in terms of the ion-induced disorder. The important result of #gamma#-irradiation on the cation distribution, structural and magnetic properties is the change of ratio Fe"2"+/Fe"3"+. Possible reasons on the results are proposed.

2010-09-01

358

Effect of #gamma#-irradiation on commercial polypropylene based mono and multi-layered retortable food packaging materials

Young rats were given a single irradiation dose (0.5, 2, 5 or 8 Gy) to the left knee-joint. The right unexposed knee-joint served as control. The animals were decapitated 1.5, 3, 7, 14 or 30 days after the irradiation. Longitudinal bone growth in the tibial epiphysis was established using tetracycline as an intravital marker. During the first 1.5 days after irradiation with 5 and 8 Gy, the growth was slightly inhibited (6-7%). Maximum growth retardation (20%) was found 7 to 14 days after irradiation with 5 and 8 Gy. No consistent effect occurred after 0.5 and 2 Gy. Between 14 to 30 days following irradiation growth was normalized.

1983-01-01

359

Development and Reproduction of grape phylloxera on irradiated in vitro cultured rootstocks

Irradiation processing of food in the prepackaged form may affect chemical and physical properties of the plastic packaging materials. The effect of #gamma#-irradiation doses (2.5-10.0 kGy) on polypropylene (PP)-based retortable food packaging materials, were investigated using Fourier transform infrared (FTIR) spectroscopic analysis, which revealed the changes happening to these materials after irradiation. The mechanical properties decreased with irradiation while oxygen transmission rate (OTR) was not affected significantly. Colour measurement indicated that Nylon 6 containing multilayer films became yellowish after irradiation. Thermal characterization revealed the changes in percentage crystallinity.

2007-07-01

360

#gamma# irradiation of aqueous solutions of human hemoglobin in atmospheres of air and argon

The ability of a local strain of grape phylloxera to develop and reproduce on irradiated in vitro cultured rootstocks (Ru140, R99 and 3309C and one local variety 'Helwani' was determined. The results showed that there was great variation in developmental time and reproduction of phylloxera between irradiated and unirradiated in vitro cultured plants. Survival, number of eggs and mean developmental time were greatly reduced when phylloxera was reared on irradiated rootstocks. Based on the examined biological parameters of phylloxera, all tested rootstocks would be more resistant toward such destructive insect when they were irradiated. Thus, phylloxera resistance was enhanced when in vitro cultured plants were treated with low doses of gamma irradiation. (author)

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Quality Management for Neutron Transmutation Doping of Silicon Ingot in HANARO

In this study, the degrees of destruction of hemoglobin irradiated in atmospheres of air and argon were compared. Hemoglobin preparations were irradiated in the forms: oxyhemoglobin (HbO_2) deoxyhemoglobin (Hb"2"+) and methemoglobin (MetHb) applying doses of 0.5 to 5 Mrad. The degree of hemoglobin destruction was estimate on the basis of changes in the values of the absorption coefficient at the Soret band, the absorption ratio A_5_0_5/A_5_6_3 determined after conversion of irradiated preparations into MetHb, absorption coefficinets for pyridine hemochromogen obtained from irradiated preparations, and changes in parameters characterizing the hemoglobin oxygenation reaction (log p/sub 1/2/O_2 and the Hill n coefficient). The calculated oxygen enhancement ratios S were generally higher than 1 for the parameters estimated. This indicates that the presence of oxygen during irradiation ...

362

Nanoporous structure formations on germanium surfaces by focused ion beam irradiations

By using this doping method, silicon semiconductors with extremely uniform dopant distributions can be produced, and this is the dominant advantage of NTD compared with a conventional chemical doping. Good uniformity of a dopant concentration is usually required for high power applications such as thyristor (SCR), IGBT, IGCT and GTO and for special sensors. Achieving an accurate neutron fluence corresponding to a target resistivity as well as a uniform irradiation is the prime target of a neutron irradiation for NTD. Generally, in order to reach an accurate neutron fluence, a real time neutron flux is monitored by a neutron detector such as a Self-powered Neutron Detector(SPND). And, after an irradiation, the total irradiation fluence is confirmed by measuring the absolute activity of a neutron activation sample that has been irradiated with a silicon ingot, and thus the SPND can be ...

2007-10-15

363

Irradiation hardening and loss of ductility of type 316L(N) stainless steel plate material due to neutron-irradiation

The formation of porous structures of nanometre size (nanoporous structures) on germanium (Ge) surfaces by focused ion beam (FIB) irradiations was investigated using various FIB conditions such as ion species, irradiation energies, total fluences, fluence rates, and incident angles. FIB-irradiated regions were observed using a scanning electron microscope and an atomic force microscope. It is found that, using a focused Ga ion beam (Ga FIB) at an energy of 100 keV, the irradiated Ge surface swelled up to ion fluence of 2 x 10"1"7 cm"-"2 with nanoporous structures and then was etched for larger fluences. The shape of swollen nanoporous structures depended on the fluence rate and the incident angle of the Ga FIB. However, such porous structures were observed neither for low-energy (15-30 keV) FIB irradiations using Si and Au ions nor for high-energy (200 keV), heavy ion (Au) ...

2007-11-07

364

Intraoperative and external beam irradiation for locally advanced colorectal cancer.

Type 316 stainless steel is the primary candidate austenitic structural material for fusion first wall constructions. Here, type 316L(N) stainless steel plate material has been irradiated up to 10 dpa at temperatures of 80, 225, 325, and 425 C in the High Flux Reactor (HFR) of Petten. Tensile tests have been performed in the temperature range from RT to 575 C at a conventional strain rate of 5 x 10"-"4 s"-"1. The results of the tensile tests are analyzed in terms of irradiation hardening and loss of ductility due to irradiation. Tensile properties saturate in the early stage (within 0.65 dpa) at the lowest applied irradiation temperature. It is indicated that the most severe degradation of tensile ductility occurs in the temperature range of 275 to 350 C. Comparison with literature data revealed a large scatter in irradiation hardening at irradiation ...

1994-06-20

365

Inherited sterility induced in progeny of gamma irradiated males and females spiny bollworm, Earias Insulana boisd ,effect on fecundity, fertility and mating

In view of poor local control rates obtained with standard treatment, intraoperative radiation (IORT) using electrons was combined with external beam irradiation and surgical resection, with or without...Full Text Available

1988-01-01

366

Hardening of ion-irradiated A533B steels investigated with nanoindentation technique

adult males and females, less than 24 hours old, of the spiny bollworm, Earias Insulana boisd. were irradiated with sub sterilizing doses of 50,80,100 and 150 gray (Gy). treated moths were out crossed with normal adults and observed for their ability to reproduce. inherited deleterious effects resulting from irradiation of p_1 moths were recorded for several generations. the reduction in both fecundity and egg viability increased by increasing the dose applied to p_1 adult moths .at all tested doses, the females were more radiosensitive than males, as for reduction in fecundity and egg viability. the progeny from irradiated parental females are not as sterile as the progeny from irradiated parental males. the reduction of egg hatching continued in the progeny of irradiated males through F_1 and to lesser extent through F_2 .on the other hand , irradiation of P_1 ...

2004-02-01

367

Experimental studies on reconstruction of peripheral arteries by high voltage cathode ray irradiated allografts

Neutron irradiation embrittlement of reactor pressure vessel (RPV) steels is one of the critical issues on aging management for long term operation of nuclear power plants. Mechanistic understanding of embrittlement is a key to accurate prediction of embrittlement, especially after long term operation where the mechanical test data are sparse. Since matrix hardening is the source of the embrittlement, we focus on matrix hardening of A533B bainitic pressure vessel steel. Bainitic matrix is composed of lath structure made by ferrite and carbides, therefore it is important to understand how this structure affects hardening behavior, and to understand irradiation response of each phase. As the typical dimension of lath structure of A533B is about one micron, nanoindentation technique is suitable for the estimation of hardening of each phase. MV ion accelerators were used for controlled irradiation because MeV ion ...

2008-10-13

368

Effects of gamma irradiation on the physical properties of laminated packaging materials. 2. polypropylene-polypropylene, polypropylene-polyethylene, and polyester-polyethylene

The use of cathode ray irradiated arterial allografts on the reconstruction of small peripheral arteries is described. The fate of irradiated arterial allografts implanted subcutaneously in rats was compared histologically with that of allografts which were fresh, frozen or stored in 70% alcohol. Follow-up studies were made of 10 dogs in which irradiated arterial allografts had been implanted in the femoral artery to be evaluated; long term patency by arteriography, gross and histologic changes of the implanted allografts, and the luminal surface of the implanted allografts by scanning electron microscopic studies. For the purpose of antigenic studies, extracts of canine arteries which had been irradiated, frozen or stored in 70% alcohol, were prepared and tested by the following immunological methods: precipitation, Ouchterlony gel diffusion, and passive cutaneous anaphylaxis. From the results obtained ...

1976-01-01

369

Effects of gamma and electron beam irradiation on the properties of calendered cord fabrics

This experiment was done to determine the effects of irradiation on the physical properties of three kinds of laminated packaging materials, i.e. polypropylene-polypropylene, polypropylene-polyethylene, polyester-polyethylene. Observations were made on pinhole production, leakage, oil resistance, resistance against insect penetration, colour, odour tensile strength, elongation at break, seal strength and tear resistance. The samples were irradiated with doses of 0, 5 and 10 kGy, then stored at room temperature and examined after 0, 3, 6 and 12 months of storage. The results showed that irradiation doses up to 10 kGy, as well as storage up to 12 months, did not create pinholes, or leakage in pouches prepared from laminated films. The resistance of the films to oil and insect penetration, the colour, and the odour were also unchanged. Both irradiation and storage treatments had a significant effect on ...

370

Effect of carbon on irradiation hardening of reduced-activation 10Cr-30Mn austenitic steels

The effects of gamma and e-beam irradiation on mechanical and structural properties of nylon 66 (Ny 66), nylon 6 (Ny 6) and poly(ethylene terephthalate) (PET) fabrics used in tyres were investigated. The untreated (greige), treated cords and calendered fabrics were irradiated at different doses. It is found that the effects of high energy irradiation on greige, treated cords and calendered fabrics are similar. No protective effect of compounds used in calendering was observed against radiation-induced oxidative degradation. The deterioration effect of gamma irradiation on mechanical properties is much higher than that of e-beam irradiation for all types of samples. Limiting viscosity numbers of both gamma and e-beam irradiated nylon 6 and nylon 66 cords were found to decrease with increasing dose. It is concluded that PET calendered fabric has higher resistance ...

2010-03-15

371

Effect of #gamma#-irradiation on relaxation properties of sealants on organosilicon rubber base

Tensile properties of reduced-activation 10Cr-30Mn austenitic steels with carbon levels from 0.003 to 0.55% were investigated over the temperature range from room temperature to 873 K after neutron irradiation in the Japan Materials Testing Reactor at 573 K to 8.5x10"2"2 n/m"2. Irradiation-induced increase in yield stress increased significantly with carbon concentration up to about 0.1% and it was constant above 0.1% carbon. A high density of dislocation loops with small (below 10 nm) and large (20-30 nm) sizes formed during irradiation. The high density, small loops caused a large irradiation hardening, while the large loops contributed only slightly to irradiation hardening. It was considered that carbon atoms formed the small loops together with irradiation defects. The deformation channeling was observed in the irradiated high carbon ...

372

DNA alterations detected in the progeny of paternally irradiated Japanese medaka fish (Oryzias latipes).

The dielectrical properties of organosilicon sealants have been studied in the wide range of temperatures in the low and radio frequencies range. The effect of thermal treatment and #gamma#-irradiation on these properties is discussed.

373

Cerebral calcification and learning disabilities following cranial irradiation for medulloblastoma.

A nonmammalian test system for germ-cell mutagenesis has been developed by using the Japanese medaka fish. We describe a system for detecting DNA alterations in F1 progeny descended from the gamma-irradiated...Full Text Available

1995-01-03

374

Calculations of physical and chemical reactions produced in irradiated water containing DNA

Six children who received craniospinal irradiation for medulloblastoma when they were under 10 years of age developed learning disabilities. Four exhibited associated temporal lobe calcification on...Full Text Available

1990-12-01

375

Antioxidant properties of natural substances in irradiated fresh poultry

Initial results obtained with a Monte Carlo computer program designed to link initial physical events in irradiated liquid water with subsequent chemical and biological events are presented. 10 refs., 4 figs., 3 tabs.

1985-01-01

376

Utilization of the HANARO

This study was undertaken to determine if a combined treatment (marinating in natural plant extracts or vacuum) with irradiation could have a synergistic effect, in order to prevent the lipid oxidation resulting in the development of undesirable flavours. The fresh chicken legs were irradiated at 0,3 and 5 kGy. The fatty acids composition of lipids was identified using gas liquid chromatography. The effect of irradiation treatment combined with a pre-treatment on the fatty acids composition was followed. The day after irradiation, ten panallists were asked to evaluate, using the instruction scaling, the overall appearance, the odor, the flavor and the overall acceptability of the samples. The major fatty acids identified in lipids were oleic acid, palmitic acid, palmitoleic acid and stearic acid. Pre-treatments have a significant effect on linoleic acid (C18:2) and higher fatty acids. The unsaturated ...

1998-06-01

377

Three-dimensional damage distributions in ion-irradiated silicon and pyrolytic graphite as revealed by modified tomography in combination with RBS and NDP

Radioisotope facilities were operated to support research, development and production of radioisotopes. Irradiation facilities were operated to offer irradiation service to the clients. Even though intensive periodical checks and some essential maintenance had been carried out the results of RI facility maintenance seemed to be not much satisfactory due mainly to the shortage of skilled manpower and maintenance expenses. High intensity {gamma} irradiator was normally operated 426 times for overall 3,440 hrs, and the low intensity {gamma} irradiator was operated 157 times for overall 11,092 hrs, respectively. (author)

1998-12-01

378

The role of lesions of DNA in senescence of seeds of Lupinus polyphyllus L. induced by chronic low-intensity irradiation

Short communication.

1995-12-31

379

The pharmacological activity of medical herbs after microbiological decontamination by irradiation

A nonlinear relationship between the time of accelerated aging of Lupine seeds and the indices of its survival as well as the single-strand DNA amount in cells from these seeds is established. The character of this relationship is essentially altered in chronically irradiated lupine seeds from the Chernobyl NPP exclusion zone and seems more complicated. The possible role of repair systems in these effects is discussed. The fact that chronic irradiation in low doses can modify the course of senescence in lupine seeds reflects its high biological efficiency comparing with acute irradiation.

2000-08-01

380

The effects of gamma irradiation of food contact plastics on the extent of migration of hindered phenol antioxidants into fatty food simulants

In the Institute of Nuclear Chemistry and Technology research on microbiological decontamination of medicinal herbs by irradiation has been carried out since 1996. It was shown that using ionizing radiation (a dose of 10 kGy) can obtain satisfactory results of microbiological decontamination of these products. The content of essential biologically active substances such as essential oils, flavonoids, glycosides, anthocyans, antra-compounds, poliphenoloacids, triterpene saponins, oleanosides and plants mucus did not change significantly after irradiation. Pharmacological activity of medicinal herbs has been found satisfactory after microbiological decontamination by irradiation.

2000-03-01

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381

Study of the Behavior of Neutron and gamma Irradiated Double Diffusion Transistors Using the Ibis Model.

In view of the interest in the use of gamma irradiation to extend the storage life of pre-packaged foods a report is made on the effects of gamma radiation on the migration of Irganox 1076 and Irganox 1010, antioxidants present in food packaging plastics, into synthetic triglyceride fatty-food simulant HB307 and iso-octane. The extent of migration was assayed by h.p.l.c. techniques. Migration into HB307 and iso-octane decreased steadily as irradiation progressed suggesting that gamma irradiation of packaging materials helps to prevent the contamination of food by antioxidants in the packaging. (U.K.).

382

Studies on lipids in fractions of spherosomes and mitochondria of #gamma#-irradiated seeds of peanuts and walnuts

For abstract, see NSA 26 23, number 56263.

1972-01-01

383

... chemical radiation effects decomposition extraction columns gamma radiation

1972-01-01

384

SCINTILLATION COUNTERS

Radiotherapeutic methods for Ewing's sarcoma of the long tubular bones in children

... 89 11 August 195Z SCINTILLATION COUNTERS *Subtask uder Effects of Irradiation, AMRL Project No. ... 89 SCINTILLATION COUNTERS* by ...

1952-08-11

385

Low temperature proton irradiation of amorphous Pd/sub 80/Si/sub 20/ prepared by ion implantation

Radiotherapeutic results of the Ewing sarcoma of the long tubular bones in 140 pediatric patients aged 3-16 are analyzed with the respect to different methods of irradiation. Three-field irradiation, the fields being located at 120 deg to one another with daily irradiation of all three fields at a focal dose of 2 Gy, was found superior in treatment of primary neoplasm. It is stressed that the disease termination mainly depends on the efficiency of primary neoplasm treatment, as the neoplasm reccurence generally is followed by metastases. Radiation load is calculated for maximal irradiation area of soft tissues in children.

386

Irradiation of microbial controlling on package tofu

The damage induced by low-temperature proton irradiation in amorphous Pd/sub 80/Si/sub 20/ prepared by ion implantation is studied via electrical resistivity measurements. Our experimental results concerning the initial damage rate and the resistivity saturation are compared to the results obtained for electron and high energy /sup 16/O irradiation of amorphous Pd/sub 80/Si/sub 20/ quenched from the melt. The resistivity curve is analyzed in terms of irradiation-induced point defects.

1984-05-01

387

Irradiation by carbon ions?: why? How?; Irradiation par ions carbone: pourquoi? Comment?

The effects of irradiation on microbiological controlling, nutrient and sensory qualities of packaged tofu (bean curd) stored at commercial condition. Results showed that D10 values of Listeria innocua and Samonella enteritidis inoculated in packaged tofu were 0.225 and 0.240kGy, respectively. Irradiation dose lower than 2.0kGy had no significant effects on content of crude protein and amino acid (p>0.05). ?-irradiation could decrease microbial in packaged tofu and 2.0kGy should be applied to ensure the hygienic quality of the products. (authors)

2009-08-01

388

Influence of dose distribution and flow pattern between irradiation stages on removal of NO{sub x}

The interest of irradiation by carbon ions is in the fact that the carbon ions leave all their energy to a determined depth. ( phenomenon known under the name of Bragg peak)This high diffusion in tissue gives an RBE particularly high. The indications of this therapy are chordomas, and chondrosarcomas of the skull base, some cyst adenoid carcinomas, pulmonary cancer, sarcomas, hepato carcinomas, melanomas. In the light of results in term of efficiency, the place of irradiation by carbon ions should widen. (N.C.)

2006-11-15

389

In-situ polymerization of vinyl pyrrolidinone on nylon 66 by gamma radiation

Short communication. 1 ref., 4 figs.

1996-12-31

390

Formation of oriented nanocrystals in an amorphous alloy by focused-ion-beam irradiation

The polymerization of vinyl pyrrolidinone on nylon 66, with the assistance of aqueous phenol and formic acid, was investigated by mutual and post irradiation procedures. Both solvents were found to greatly facilitate the polymerization with the post irradiation procedure, whereas neither presented any advantage with the mutual irradiation procedure. Tensile properties of the modified fibers were affected in similar ways by both the irradiation procedures and solvents in that the only notable changes were the somewhat higher extensions at yield and at break. The moisture regain values of the treated yarns and fabrics were increased up to three-fold. Surface morphology of the modified fibers was revealed by SEM.

1984-10-01

391

Formation and coarsening of Ga droplets on focused-ion-beam irradiated GaAs surfaces

Structural changes of a Ni-P amorphous alloy under focused-ion-beam (FIB) irradiation have been examined using transmission electron microscopy. On the irradiated plane, the formation of crystallographically orientated nanosized crystals (NCs), with the particle size of approximately 10 nm, was observed. A series of electron diffraction analyses have revealed that NCs have a face-centered-cubic (fcc) structure and the following orientation relationships between the NCs and the FIB direction were found. These are, irradiated plane//(111)_f_c_c and FIB direction//_f_c_c.

2002-12-09

392

Femoral neck fracture after irradiation therapy

We have investigated the formation and coarsening of Ga droplets on focused-ion-beam (FIB) irradiated GaAs surfaces. To separately examine formation and coarsening, Ga droplets were fabricated by Ga"+ FIB irradiation of GaAs substrates with and without pre-patterned holes. We determined the droplet growth rate and size distribution as a function of FIB energy following irradiation. The data suggest a droplet formation mechanism that involves Ga precipitation from a Ga-rich layer, followed by droplet coarsening via a combination of diffusion and Ostwald ripening or coalescence via droplet migration (dynamic coalescence).

2009-10-12

393

Effects of gamma irradiation on the sperm transmission and oviposition response in Helicoverpa armigera (L. NOCTUIDAE)

Japanese Mar 1999 p. 371-372 Japan Shi, Dequan Yamazaki, Takashi

1999-03-01

394

Effect of Radiation Exposure on the Retention of Commercial NAND Flash Memory

Transmissions of sperm by unirradiated and irradiated cotton bollworm, Helicoverpa armigera, were studied by live dissection of females immediately after the initiation of mating. In cotton bollworm the sperm transfer was rather a complex process. In fact unirradiated males failed to transfer sperm in about 19% of their matings. When irradiated with 250 Gy and 400 Gy, aberrations of sperm transmission were about 21% and 50% respectively. The failure of spermatophore 'cap' location was an important reason of sperm transmission aberrations. When females mated to high-dose-irradiated males, their oviposition response appeared abnormal

2002-02-01

395

EFFECTS OF EXCIMER LASER IRRADIATION ON THE ...

We have compared the data retention of irradiated commercial NAND flash memories with that of

2011-01-01

396

Development of equipment for irradiated nuclear fuel reprocessing plant

... Personal Author(s) : ROTHSCHILD, M. ; EHRLICH, DJ ; SHAVER, DC. Report Date : 1989. Pagination or Media Count : 3. ...

397

Detection of Pulsed Photostimulated Luminescene Signals Emitted by Infrared Stimulations of Irradiated spices during Stroage under Two Conditions /

2002 p. 9-10, 83-84 Russian Federation Glagolenko, Yu.V. Dzekun, EG

398

Detection of Pulsed Photostimulated Luminescence Signals Emitted by Infrared Stimulation of Irradiated Spices during Storage under Two Conditions

Full Text Available

399

DNA double strand breakage after UV irradiation of yeast cells; DNA-Doppelstrangbrueche nach UV-Bestrahlung in Hefezellen

Full Text Available

2001-09-01

400

Computer-assisted rotation and multiple stationary irradiation technique

No abstract prepared.

2000-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

Changes in mass density and sound velocity of amorphous Pd{sub 80}Si{sub 20} by low temperature ion irradiation.

A computer-assisted rotation and stationary conformation radiotherapy system with overrunning multileaf collimators has been developed. This system can produce any shape of target volume, including a number of target areas outside the axis of the rotation, regardless of the location of the axis at 360"0 rotation irradiation. In addition, by changing the dose rate and deleting a partial region within a field, multiple stationary irradiation can produce more homogeneous target volumes - thus avoiding excessive irradiation to critical organs - than the rotation technique. (orig.).

402

Cerebral artery replacement by use of arterial graft irradiated with high voltage cathode ray

No abstract prepared.

1998-01-01

403

"2"0"3Pb yields while irradiating thallium with protons and deuterons

Japanese (Sep 1974). Japan Kudo, Susumu . Kansai Medical School,

1974-01-01

404

The recovery of zinc and cadmium following 6.1 MeV alpha particle irradiation at 4.2 K

... data deuteron beams energy dependence errors gamma radiation lead 203

405

The characterization of electron beam and its importance

The paper reports the recovery of zinc and cadmium following 6.1 MeV alpha particle irradiation at 4.2 K as studied by means of electrical reistivity measurements. Specimens of 10 #mu#m thick have been used in order to obtain a homogeneous defect distribution over the whole thickness of the specimen. The pre-irradiation resistivity ratios were 700 and 750 for cadmium and zinc, respectively. (Auth.).

406

Radiation damage on amorphous metals. [Helium ion, neutron and gamma ray irradiation

The necessity of the electron beam machine characterization via dose measurement is discussed. It includes a measurement of comprehensive dose distribution (at known X and Z axis) for verification of the machine performance. The acquired data were then used to develop the irradiation parameters such as energy, current, distance, conveyor speed, exposure rate and depth inside product to be irradiated. These parameters will be used as a guide for the routine irradiations. (Author)

2003-07-22

407

Production of "2"0"3Pb by proton irradiation of Bi

The structural variations of amorphous metals, such as Pd/sub 80/Si/sub 20/, with irradiation of helium ion, neutron, and gamma ray have been mainly pursued by the method of X-ray diffraction and thermal analysis. It should be noticed that the amorphous metals show a radiation resistance, that is, no remarkable structural changes under helium ion, neutron, and gamma ray irradiation.

1982-04-01

408

Preparation of pinewood/polymer/composites using gamma irradiation

Production of lead-203 by proton irradiation of bismuth metal has been investigated as a replacement method for commercially available lead-203. Targets of bismuth metal (0.1 cm thick) were irradiated for periods of 1-3 hours with 90 MeV protons. After processing of the target, the estimated yield of lead-2-3 was 30 millicuries/microamp.

1990-06-24

409

Isolating the effect of radiation-induced segregation in irradiation-assisted stress corrosion cracking of austenitic stainless steels

Wood/polymer composites (WPC) have been prepared from pinewood with different compounds using gamma irradiation: butyl acrylate, butyl methacrylate, styrene, acrylamide, acrylonitrile, and unsaturated polyester styrene resin. The polymer loading was determined with respect to the compound concentration and the irradiation dose. The polymer loading increases generally with increase in the monomer or polymer concentration. Tensile and compression strength have been improved in the four cases, but no improvement was observed using unsaturated polyester styrene resin or acrylamide.

2006-09-15

410

Irradiation effect on properties of passive film formed on an AISI 304 type stainless steel

Post-irradiation annealing was used to help identify the role of radiation-induced segregation (RIS) in irradiation-assisted stress corrosion cracking (IASCC) by preferentially removing dislocation loop damage from proton-irradiated austenitic stainless steels while leaving the RIS of major and minor alloying elements largely unchanged. The goal of this study is to better understand the underlying mechanisms of IASCC. Simulations of post-irradiation annealing of RIS and dislocation loop microstructure predicted that dislocation loops would be removed preferentially over RIS due to both thermodynamic and kinetic considerations. To verify the simulation predictions, a series of post-irradiation annealing experiments were performed. Both a high purity 304L (HP-304L) and a commercial purity 304 (CP-304) stainless steel alloy were irradiated with 3.2 MeV protons at ...

2002-04-01

411

Irradiation effect on properties of passive film formed on an AISI 304 type stainless steel

The study by impedance and photoelectrochemical measurements of passive films formed on an AISI 304 type stainless steel shows that important parameters of the electronic structure of these films are modified under ..cap alpha.. irradiation, namely: width of the space charge region, donors concentration and diffusion length for minority carriers. The consequences of ..cap alpha.. irradiation on localized corrosion processes are discussed.

1989-01-01

412

Industrialization development of food irradiation in China

The study by impedance and photoelectrochemical measurements of passive films formed on an AISI 304 type stainless steel shows that important parameters of the electronic structure of these films are modified under #alpha# irradiation, namely: width of the space charge region, donors concentration and diffusion length for minority carriers. The consequences of #alpha# irradiation on localized corrosion processes are discussed.

1989-01-01

413

Effects of gamma irradiation on physiological effectiveness of Korean medicinal herbs

This report introduces present status on food irradiation at home and abroad in detail. It also introduces the scientific research and application in reducing diseases caused by food borne pathogens, quarantine control of import and export products, grain store and killing insects in traditional Chinese medicine. The report also analyzes the problems in developing food irradiation in China and gives some suggestions

2004-04-01

414

Effects of gamma irradiation on microbial contamination and extraction yields of Korean medicinal herbs

Effects of gamma irradiation on the physiological effectiveness of Korean medicinal herbs were investigated. The physiological effectiveness including antioxidant and anticomplement function, nitrite scavenging and electron donating ability of Korean medicinal herbs by gamma irradiation at 10 kGy did not differ from that of the nonirradiated control.

1999-03-01

415

Developments and potential of radiation processing in the Philippines

Effects of gamma irradiation on hygienic quality and extraction yields in twenty-one kinds of Korean medicinal herbs were investigated. Gamma irradiation at 5-10 kGy inactivated contaminating microorganisms. The total extraction yield in fifteen kinds of the investigated medicinal herbs increased by 5-25% by a dose of 10 kGy. (author)

2000-01-01

416

Development of heavy-ion irradiation technique for single-event in semiconductor devices

This paper describes the research and development activities in three areas of radiation processing, namely: food irradiation, medical product sterilization and wood plastic combination. Plans and efforts exerted to acquire a larger gamma source to augment our present 5,000 curie source are discussed. Cost estimates for a radiation facility are presented on the basis of the market potential of food irradiation and medical product sterilization. Existing local industries that can benefit from the adaptation of irradiation technology in their processing requirements are described.

1981-01-01

417

Decree of the Ministry of Health about conditions of irradiation of food, permissible additional substances or other food components, which can be subjected to ionizing radiation action, their specification, maximum irradiation doses as well as about requirements for marking and introducing into turnover

Heavy-ion irradiation technique has been developed for the evaluation of single-event effects on semiconductor devices. For the uniform irradiation of high energy heavy ions to device samples, we have designed and installed a magnetic beam-scanning system in a JAERI cyclotron beam course. It was found that scanned area was approximately 4 x 2 centimeters and that the deviation of ion fluence from the average value was less than 7%. (author)

1997-03-01

418

Consumer's evaluation of the effects of gamma irradiation and natural antioxidants on general acceptance of frozen beef burger

The decree refers to conditions of irradiation of food and its components for radappertization and radurization using gamma radiation from cobalt 60 or cesium 137, X radiation or electron beam up to maximum total medium absorbed dose 10 kGy.

2003-03-04

419

$gamma$-RAY PROCESSING OF RICE. (IV.) STUDIES ON THE AVAILABILITY OF $gamma$-IRRADIATED RICE FOR KOJI

The effect of addition of rosemary and oregano extracts on the sensory quality of irradiated beef burger was investigated. Batches of beef burgers were prepared with 400 ppm of rosemary or oregano extract and a group prepared with 200 ppm of synthetic butyl-hydroxytoluene (BHT)/butyl-hydroxy-anisol (BHA) was used as a control. Half of each formulation was irradiated at the maximum dose allowed for frozen meat (7 kGy). Samples were kept under frozen conditions (-20 deg. C) during the whole storage period, including during irradiation. Two analyses were performed after 20 and 90 days to verify the influence of the addition of the different types of antioxidants and the effect of irradiation and storage time on the acceptance of the product. Thirty-three and thirty-four untrained panelists were invited to participate in the first and second test, respectively. A structured hedonic scale ranging from 1 to 9 ...

2009-04-01

420

The mouse formin (Fmn) gene: Genomic structure, novel exons, and genetic mapping

The availability of rice, gamma -irradiated up to 4.6 x 10/sup 4/ and 3.5 x 10/sup 5/r for koji was studied. The enzyme activities of koji of the steamed samples were stronger than the unirradiated rice in amylase and protease. The sensory test on the once-steamed irradiated rice was almost the same as the twice-steamed unirradiated rice. (OID)

1961-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

421

Rubidium uptake by mouse pancreatic islets exposed to 6-hydroxydopamine, ninhydrin, or other generators of hydroxyl radicals

Mutations in the mouse formin (Fmn) gene, formerly known as the limb deformity (ld) gene, give rise to recessively inherited limb deformities and renal malformations or aplasia. The Fmn gene encodes many differentially processed transcripts that are expressed in both adult and embryonic tissues. To study the genomic organization of the Fmn locus, we have used Fmn probes to isolate and characterize genomic clones spanning 500 kb. Our analysis of these clones shows that the Fmn gene is composed of at least 24 exons and spans 400 kb. We have identified two novel exons that are expressed in the developing embryonic limb bud as well as adult tissues such as brain and kidney. We have also used a microsatellite polymorphism from within the Fmn gene to map it genetically to a 2.2-cM interval between D2Mit58 and D2Mit103. 36 refs., 6 figs., 1 tab.

1997-02-01

422

Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States.

The purpose was to study the toxicity of drugs known to generate free radicals on isolated pancreatic islets. The accumulattion of "8"6Rb"+ by mouse pancreatic islets was measured in vitro. Exposing the islets to 6-hydroxydopamine, minhydrin, or phenazine methosulphate + NADH inhibited the Rb"+ uptake, whereas paraquat or acetylphenylhydrazine had no effect. This effect of 6-hydroxydopamine was prevented by either of the hydroxyl radical scavengers, sodium benzoate and mannitol, but not by the non-scavenger,urea; ninhydrin was partially protected against by mannitol but not by benzoate. Protection against 6-hydroxydopamine was also afforded by D-glucose but not by L-glucose or 3-O-methyl-D-glucose; none of the sugars protected against ninhydrin. In damaging islet beta-cells and in being protected against by D-glucose, 6-hydroxydopamine closely resembles the diabetogenic drug, alloxan. It is suggested that protection against alloxan may involve both glucose ...

423

Murine respiratory mycoplasmosis (MRM) in C57BL/6N and C3H/HeN mice: strain differences in early host responses and exacerbation by nitrogen dioxide

A rickettsia related to but distinct from the spotted fever agent, Rickettsia rickettsii, has been detected in 167 (18.9%) of 884 Rhipicephalus sanguineus taken off dogs in central and northern Mississippi. The organisms could readily be isolated in male meadow voles (Microtus pennsylvanicus), where it produced massive infections in the tissues of tunica vaginalis. It was practically nonpathogenic for male guinea pigs, although inoculation of these animals with infected tunica vaginalis of voles afforded in 30 of 38 instances solid immunity to challenge with virulent R. rickettsii. The Rhipicephalus rickettsia grew well in monolayers of chicken embryo fibroblast, Vero, mouse L, and HeLa cells. Cytopathogenic effects were minimal unless large concentrations of rickettsiae were used as inocula. It also could be established in embryonated hen eggs but only after injection of massive doses of L cell-propagated organisms. Serological tests (complement fixation, ...

1975-07-01

424

Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32. 1

The studies reported here used genetic differences in susceptibility of C57BL/6N and C3H/HeN mice and exacerbation of the disease by nitrogen dioxide (NO/sub 2/) as tools in assessing the role of early host responses in the pathogenesis of MRM. The two strains did not differ in susceptibility to infection, but C3H/HeN mice were more susceptible to and had increased severity of lung lesions 14 days after intranasal inoculation as determined by 50% biological endpoints and morphometric analysis of tissues. Exposure to NO/sub 2/ for 4 hours prior to exposure to infectious aerosols exacerbated murine respiratory mycoplasmosis (MRM) by 7 days after exposure in both mouse strains. NO/sub 2/ appeared to affect host lung defense mechanisms responsible for limiting mycoplasmal growth in the lungs. The NO/sub 2/ exposure concentration required for this effect varied with the genetic background of the host, the dose of mycoplasmas administered, and the endpoint measured. ...

1987-01-01

425

Mapping cis-Regulatory Domains in the Human Genome UsingMulti-Species Conservation of Synteny

Goosecoid is a homeobox gene first isolated from a Xenopus dorsal lip cDNA library. Homologous genes have been isolated from mouse, zebrafish, and chick. In all species examined, the gene is expressed and plays an important role during the process of gastrulation in early embryonic development. The authors report here the cloning of the human goosecoid (GSC) from a genomic library and the sequence of its encoded protein. The genomic organization and protein sequence of the human gene are highly conserved with respect to those of its Xenopus and mouse counterparts: all three genes consist of three exons, with conserved exon-intron boundaries. The sequence of the homeo-domain is 100% conserved in most vertebrates. Using somatic cell hybrid and chromosomal in situ hybridization, the gene was mapped to chromosome 14q32.1. 30 refs., 3 figs., 2 tabs.

1994-05-15

426

Immunolocalization of endothelin-B receptor in mouse intestinal tract.

Our inability to associate distant regulatory elements with the genes that they regulate has largely precluded their examination for sequence alterations contributing to human disease. One major obstacle is the large genomic space surrounding targeted genes in which such elements could potentially reside. In order to delineate gene regulatory boundaries we used whole-genome human-mouse-chicken (HMC) and human-mouse-frog (HMF) multiple alignments to compile conserved blocks of synteny (CBS), under the hypothesis that these blocks have been kept intact throughout evolution at least in part by the requirement of regulatory elements to stay linked to the genes that they regulate. A total of 2,116 and 1,942 CBS>200 kb were assembled for HMC and HMF respectively, encompassing 1.53 and 0.86 Gb of human sequence. To support the existence of complex long-range regulatory domains within these CBS we analyzed the prevalence and distribution of ...

2005-06-13

427

Genome lability in radiation-induced transformants of C3H 10T1/2 mouse fibroblasts

The endothelin-B (ETB) receptor is a G-protein-coupled receptor that binds endothelin ligands and is essential for the development of epidermal melanocytes and enteric neurons. Recent reports indicate that ETB is localized to nuclei in cardiac ventricular myocytes, although it has been thought that ETB is localized mainly on the plasma membrane. It remains unknown, however, whether this unique distribution of ETB occurs in other tissues. To elucidate the subcellular distribution of ETB in the intestine, we performed immunofluorescence of ETB in mouse intestine using a specific antibody. ETB-like immunoreactivity was detected in both the mucosal and muscle layers. In the mucosal layer, villous epithelial cells, stromal cells of the lamina propria, and cryptic cells were immunostained. Subcellularly, ETB is localized mainly to the nuclei of villous epithelial cells. In the muscle layer, immunoreactivity of ETB was localized to the myenteric plexus. These findings ...

2004-11-01

428

Examination of thermally polluted water for free living amoebae and testing for their possible pathogenic properties

We have been investigating radiation-induced neoplastic transformants of C3H 10T1/2 mouse fibroblasts for evidence of heritable changes. C3H 10T1/2 cells were treated with 8 Gy X rays. After approximately 8 weeks of culture, type II/III foci were isolated from the monolayer using cloning rings. Cell lines developed from these foci, and clones established from these cell lines, were examined for DNA content. The isolated focus-derived populations and derived clones often display aneuploidy and/or polyploidization. In one instance a clone (derived from a single cell) displayed multiple polyploidies. During passage the ploidy of many of the anomalous populations gradually reverted to the ploidy of the non-neoplastically transformed state. The morphological features associated with the neoplastic transformation event were nevertheless retained. The results demonstrate that exposure to radiation can induce, in association with morphological neoplastic transformation, a ...

1994-04-01

429

Effects of epidermal growth factor on bone formation and resorption in vivo

Water and mud samples were collected from canals and rivers which were adjacent to outlets discharging warm water of 3 power plants in Berlin. Downstream samples from 1 bathing resort were also collected. Free living amoebae were isolated from 138 water and 69 mud samples. From these respectively 156 and 73 strains could be cultured and were administered intranasally to mice for pathogenicity tests. Two Acanthamoeba strains from water and 7 from mud could be reisolated from mouse brain and or lungs, although no pathological disorders could be observed. Five Naegleria strains were negative in mouse inoculation tests. Four Acanthamoeba strains which were positive in mice were cultured at + 45 degrees C; no cytopathogenic effects were observed in tissue cultures. Acanthamoeba infective for mice could also be isolated from samples at low water temperatures. Further investigations have to show, whether changes in virulence of amoebic strains are of ...

1982-05-01

430

Doxycycline up-regulates the expression of IL-6 and GM-CSF via MAPK/ERK and NF-kB pathways in mouse thymic epithelial cells

The effects of mouse epidermal growth factor (EGF) on bone formation and resorption were examined in male mice. EGF administration (2-200 ng.g-1.day-1 ip for 7 days) induced a dose-dependent rise in plasma EGF levels that remained within physiological range. Histomorphometric analysis of caudal vertebrae showed that EGF (20 and 200 ng.g-1.day-1) reduced the endosteal matrix and mineral appositional rates after 5 days of treatment as measured by double (3H)proline labeling and double tetracycline labeling, respectively. This effect was transitory and was not observed after 7 days of EGF administration. EGF administered for 7 days induced a dose-dependent increase in the periosteal osteoblastic and tetracycline double-labeled surfaces. At high dosage (200 ng.g-1.day-1) EGF administration increased the osteoclastic surface and the number of acid phosphatase-stained osteoclasts, although plasma calcium remained normal. The results show that EGF administration at ...

1990-02-01

431

British Library Electronic Table of Contents (United Kingdom)

Thymic epithelial cells (TECs) constitute a major component of the thymic stroma which provides a microenvironment critical for developing thymocytes. We have previously demonstrated that doxycycline (Dox), a tetracycline derivative, enhances the proliferation of the mouse thymic epithelial cell line 1 (MTEC1) via MAPK/ERK signal pathway. Herein we provide evidence that Dox also has profound impact on the cytokine production by MTEC1. Specifically, the expression of IL-6 and GM-CSF, both at mRNA and protein levels, was found to be increased in a time- and dose-dependent manner with the addition of Dox. Western blotting analysis revealed that treatment with Dox-induced phosphorylation of the p65 subunit of NF-kB and ERK. Notably, Dox-induced up-regulation of IL-6 and GM-CSF was largely abol...

2011-01-01

432

A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (A{sup y}) mutation

Effects of Multi-ion Irradiation on Microstructural Changes in Lithium Titanate

Lethal yellow (A{sup y}) is a mutation at the mouse agouti locus in chromosome 2 that causes a number of dominant pleiotropic effects, including a completely yellow coat color, obesity, an insulin-resistant type II diabetic condition, and an increased propensity to develop a variety of spontaneous and induced tumors. Additionally, homozygosity for A{sup y} results in preimplantation lethality, which terminates development by the blastocyst stage. The A{sup y} mutation is the result of a 170-kb deletion that removes all but the promoter and noncoding first exon of another gene called Raly, which lies in the same transcriptional orientation as agouti and maps 280 kb proximal to the 3{prime} end of the agouti gene. The authors present a model for the structure of the A{sub y} allele that can explain the dominant pleiotropic effects associated with this mutation, as well as the recessive lethality, which is unrelated to the agouti gene.

1994-03-29

433

Correlation between tensile property and micro-hardness in reduced activation ferritic/martensitic steel irradiated at 573 K

Full text of publication follows: Li{sub 2}TiO{sub 3} is regarded as one of the most suitable candidates for the solid tritium breeder material of D-T fusion reactors. It is known that, in an operating fusion reactor, the radiation damage in Li{sub 2}TiO{sub 3} will be caused by fast neutrons, energetic tritons and helium ions generated in {sup 6}Li(n,{alpha}){sup 3}H reaction. The irradiation damage caused by such radiation may result in the microstructural changes, and the changes may affect the characteristics of Li{sub 2}TiO{sub 3} such as tritium release behavior. Thus the study of irradiation defects and microstructural changes caused by irradiation in Li{sub 2}TiO{sub 3} is essential to evaluate its irradiation performance. Simulation of the fusion reactor environment and hence the study of a synergistic effect of atomic displacement damage in Li{sub 2}TiO{sub 3} are approached by a simultaneous ...

2007-07-01

434

Monoclonal antibodies to antigens on human neutrophils, activated T lymphocytes, and acute leukemia blast cells

Full text of publication follows: Radiation hardening and embrittlement due to high-energy neutron radiation around 623 K are the important issues on reduced-activation ferritic/martensitic (RAF/M) steels. It is expected that the improvement of radiation hardening might be one of effective ways to control the mechanical properties of RAF/M after irradiation. It has been reported that the weld joint has less hardening than the base metal from the tensile test results of TIG weldments irradiated in HFIR. This report indicated that radiation hardening can be reduced by the optimization of heat treatment condition for F82H. The purposes of this study are to establish the condition of heat treatment for minimum of radiation hardening in F82H steel using Neutron/Ion-irradiation and to examine a correlation between tensile property and micro-hardness before/after irradiation. The materials used in this study ...

2007-12-10

435

Experimental models for testing respiratory tract carcinogens

The authors describe the production of two mouse hybridomas secreting monoclonal antibodies to antigenic determinants of the surface membranes of human neutrophils, activated T lymphocytes, and acute leukemic blast cells. The degree of lymphocyte stimulation was estimated from incorporation of /sup 3/H-thymidine with parallel microculture. Monoclonal antibodies of supernatants of hybridoma cultures shown here reacted in both immunofluorescence test and cytotoxicity test with surface membrane antigens on the majority of neutrophils and PHA-activated peripheral blood lymphocytes from healthy subjects, but did not give positive reactions with unactivated lymphocytes, adherent monocytes, erythrocytes, and alloantigen-stimulated lymphocytes.

1987-11-01

436

cost-benefit analysis of legumes irradiation processing in egypt

The usefulness of the mouse, rat, and Syrian golden hamster as experimental models for studies of the development of respiratory tract cancer is considered. Three different application methods for examining the effects of environmental chemicals on the respiratory tract in these species are discussed: implantation, intratracheal instillation, and inhalation. The results of various investigations are presented to demonstrate that each particular method has both advantages and disadvantages. The techniques are also considered in comparison with the human situation and in the light of obtaining the most valid data for extrapolation to man. Brief attention is paid to the relevance to respiratory tract carcinogenesis of more recently developed organ and cell culture systems.

1982-01-01

437

Use of radiosensitivity to identify irradiated fresh poultry products

This paper discusses the economics of legumes irradiation such as Chickpea,Lupin,Kidny Bean and broad and the effect of various parameters on unit processing costs. It provides a model for calculating specific unit processing costs by correlating known capital costs with annual operation cost an annual throughputs. We analysed the cost-benefit of the proposed grain irradiation facility. We took into account the cost of the capital investment, operation and other additional parameters and then estimated the unit processing cost. The investment criteria utilized for commercial evaluation were internal rate of return (I.I.R), pay back period (P.B.P), and average rate of return (A.R.R). The irradiation cost and the additional income are also discussed. The results of this analysis showed that the installation of an irradiation unit for legumes processing in Egypt would be economically feasible.

2004-01-01

438

The influence of electron-beam irradiation on some mechanical properties of commercial multilayer flexible packaging materials

Microbiological comparison between irradiated and non-irradiated foodstuff has been studied for a long time as a way to detect whether a foodstuff has been irradiated or not. Generally, the proposed methods are based on the fact that ionization select species of bacteria which are recognized to be radioresistant. So reduction or elimination of known radiation sensitive microbes from the normal endogenous microflora could give an indication that the foodstuff has been irradiated, predominance of known radioresistant bacteria should be another indication. In the present work, we try to develop a test based on the radiosensitivity of the bacteria independently of their place. These first experiments show that the determination of radiosensitivity of strains isolated from a product or even of global radioresistance of mesophilic microflora could indicate if this product has been previously submitted to ...

1990-02-14

439

Synergistic effect of helium and hydrogen for defect evolution under multi-ion irradiation of Fe-Cr ferritic alloys

The influence of electron-beam irradiation on mechanical properties of commercial multilayer flexible packaging materials based on coextruded and laminated polypropylene (PP), low-density polyethylene (LDPE), ethylene vinyl alcohol copolymer (EVOH) and poly(ethylene terephthalate) (PET), irradiated with doses up to 120 kGy, was studied. The tensile strength and elongation at break of the irradiated PET/PP film increase, while the penetration and sealing resistance decreased. In addition, the irradiated PET/LDPE/EVOH/LDPE film presented increase in the tensile strength on some radiation doses and decrease of the penetration and sealing resistance, except for sealing resistance at radiation dose of 15 kGy that resulted in a slight increase of ca 4%.

2008-09-21

440

Studies on gamma irradiated medicinal plants and spices (1): Myristica argentea, Myristica fragrans, Coriandrum sativum and Foeniculum vulgare

The purpose of this study is to evaluate the synergistic effect of helium and hydrogen on Fe-Cr ferritic model alloys, to provide basic understanding concerning development of fusion reactor components. Single, dual and triple ion-beams consisting of Fe{sup 3+}, He{sup +} and H{sup +} were used for irradiation, at temperatures 470-600 deg. C and dose to 50 dpa at 1 {mu}m. The dual beam irradiation with He enhanced cavity nucleation extensively to swelling of about 0.4%, whereas the dual beam irradiation with H did not significantly affect the microstructure. In the case of triple ion irradiation, the synergistic effect of He and H was confirmed clearly; relative large void formation and enhanced swelling to almost 5%. The synergistic effect suggests that the role of H is important for void growth and dislocation bias.

2004-08-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

Spallation and 14-MeV neutron irradiation of stabilized NbTi superconductors

Medicinal plants i.e. dried seeds of myristica argentea, myristica fragrans, coriandrum sativum and foeniculum vulgare were stored for 0 and 6 months, with and without gamma irradiation at 5 kGy. No detectable changes were seen in infrared and UV spectra, GLC chromatograms and refraction indices of steam distilled, essential oils from the irradiated medicinal plants. The same results were also obtained from irradiated samples stored for 6 months at ambient conditions. Storage for 6 months caused significant changes in the gas liquid chromatograms and UV spectra of all samples compared to non-stored samples. The moisture content of all samples packed in polyethylene bags seems to be constant after 6 months of storage. No measurable changes were found in the amount of essential oil content caused by irradiation.

1981-10-01

442

SP-100 fuel pin performance: Results from irradiation testing

The results on 5 K irradiation available so far may be summarized as follows. (1) Increases of j/sub c/ following neutron irradiation occur only in conductors which are far from the optimal metallurgical treatments. (2) The changes of j/sub c/ following neutron irradiation and a thermal cycle to room temperature are small and in most cases comparable to the results obtained after 77 K irradiation. (3) The data available so far indicate that the degradation of j/sub c/ at 8 T is larger by about 5 to 10% than the corresponding changes at 5 T at a neutron fluence of 1.3 x 10/sup 22/ m/sup -2/ (E > 0.1 MeV). (4) The increase of Cu-resistivity is significant even after a thermal cycle to room temperature and requires design changes for a stable magnet operation.

1983-08-01

443

Radiation imposed limits on superconducting magnets: A data base for copper stabilizers

A total of 86 experimental fuel pins with various fuel, liner, and cladding candidate materials have been irradiated in the Experimental Breeder Reactor-II (EBR-II) and the Fast Flux Test Facility (FFTF) reactor as part of the SP-100 fuel pin irradiation testing program. Postirradiation examination results from these fuel pin are key in establishing performance correlations and demonstrating the lifetime and safety of the reactor fuel system. This paper provides a brief description of the in-reactor fuel pin tests and presents the most recent irradiation data on the performance of wrought rhenium (Re) liner material and high density UN fuel at goal burnup of 6 atom percent (at. %). It also provides an overview of the significant variety of other fuel/liner/cladding combinations which were irradiated as part of this program and which may be of interest to more advanced efforts.

1993-09-01

444

Procedure for radiation dose control in irradiated tissues during electron-beam therapy

Two of eight differently prepared copper stabilizer samples, previously irradiated in the RTNS-II at LLNL, the IPNS-1 and the BSR at ORNL, have been irradiated to a fluence of 1.33 /times/ 10/sup 22/ n/m/sup 2/ at RTNS-II. During the course of the irradiation the samples were periodically removed (without warming) for measurements of the transverse magnetoresistance and returned for continued irradiation. This experiment extends the range of neutron-irradiation-induced resistivity by a factor of five over the previous experiments. A simple model is developed which reproduces the magnetoresistance results of all the experiments to an accuracy of 2.5%. 13 refs., 6 figs.

1987-10-28

445

Patterns of proliferation and differentiation of irradiated haemopoietic stem cells cultured on normal 'stromal' cell colonies in vitro

The invention refers a procedure of radiation dose control in irradiated tissues during electron-beam therapy. It aims at meeting the planned radiation dose for diseased tissues and taking care of the healthy ones. Therefore, the dose distribution required is determined before irradiation in consideration of such factors as energy-dependence of detector sensitivity, self-absorption within the tissue, and relative biological effectiveness. Furthermore, the expected intensity distribution of secondary quantum radiation excited in the irradiated tissue is calculated. A radiation detector for local resolution is used for registration. During irradiation the calculated intensity distribution is compared with the measured one. The invention is applicable in radiation therapy with monoenergetic electron beams.

1984-11-08

446

Packing for food irradiation

Experiments were designed to elucidate whether or not the irradiated bone marrow cells receive any stimulation for the self-replication and differentiation from normal 'stromal' cell colonies in the bone marrow cell culture in vitro. When irradiated or unirradiated bone marrow cells were overlaid on the normal adherent cell colonies, the proliferation of haemopoietic stem cells was supported, the degree of the stimulation depending on the starting cellular concentration. There was, however, no significant changes in the concentration of either CFUs or CFUc regardless of the dose of irradiation on the bone marrow cells overlaid. This was a great contrast to the dose-dependent decrease of CFUs or CFUc within the culture in which both the stem cells and stromal cells were simultaneously irradiated. These results suggest that the balance of self-replication and differentiation of the ...

1981-09-01

447

Microbial pathogens in raw pork, chicken, and beef: benefit estimates for control using irradiation

Joint FAO/IAEA/WHO Expert Committee approved the use of radiation treatment of foods. Nowadays food packaging are mostly made of plastics, natural or synthetic, therefore effect of irradiation on these materials is crucial for packing engineering for food irradiation technology. By selecting the right polymer materials for food packaging it can be ensured that the critical elements of material and product performance are not compromised. When packaging materials are in contact with food at the time of irradiation that regulatory approvals sometimes apply. The review of the R-and-D and technical papers regarding material selection, testing and approval is presented in the report. The most information come from the USA where this subject is well elaborated, the International Atomic Energy Agency (IAEA) reports are reviewed as well. The report can be useful for scientists and food irradiation plants ...

448

Materials for cold neutron sources: Cryogenic and irradiation effects

Various control procedures have been suggested for reducing foodborne infectious diseases. Receiving considerable attention is irradiation. This report estimates the medical and wage (or productivity) benefits associated with prevention of five human diseases transmitted by beef, pork, and chicken. (These diseases can also be transmitted by other vectors, such as eggs, milk, and pets. But these sources are not included in the analysis.) All of these foodborne infectious diseases - salmonellosis, campylobacteriosis, trichinosis, tapeworm, and toxoplasmosis - could be significantly reduced by irradiating meat and poultry. The Food and Drug Administration (FDA) has just approved irradiation of pork to prevent trichinosis (50FR 29658-59) and is considering approval of irradiation of chicken to kill Salmonella. 22 references.

1985-12-01

449

Irradiation of human insulin in aqueous solution, first step towards radiosterilization

Materials for the construction of cold neutron sources must satisfy a range of demands. The cryogenic temperature and irradiation create a severe environment. Candidate materials are identified and existing cold sources are briefly surveyed to determine which materials may be used. Aluminum- and magnesium-based alloys are the preferred materials. Existing data for the effects of cryogenic temperature and near-ambient irradiation on the mechanical properties of these alloys are briefly reviewed, and the very limited information on the effects of cryogenic irradiation are outlined. Generating mechanical property data under cold source operating conditions is a daunting prospect. It is clear that the cold source material will be degraded by neutron irradiation, and so the cold source must be designed as a brittle vessel. The continued effective operation of many different cold sources at a number of ...

1990-01-01

450

British Library Electronic Table of Contents (United Kingdom)

The degradation of irradiated human insulin in aqueous solutions was investigated in order to protect the protein against ionizing radiation. The influence of the drug concentration, excipients and irradiation temperature were studied.Aqueous solutions at pH 2 were irradiated by gamma rays or by accelerated electrons. Two different high-performance liquid chromatography (HPLC) methods were used: reverse-phase high-performance liquid chromatography (RP-HPLC)/UV and size exclusion liquid chromatography (SEC/UV) to investigate both the fragmentation and the formation of higher molecular weight proteins.In solution without excipients irradiated at ambient temperature at 10kGy, the loss of human insulin is almost complete. Addition of radio-protecting excipients (free radicals scavengers) and c...

2007-01-01

451

Irradiation induced dislocation loop and its influence on the hardening behavior of Fe-Cr alloys by an Fe ion irradiation

Influence of B atom diameter on annealing recovery rates of superconducting transition temperatures in irradiated A-15 (A_3B) compounds

Nano indentation analysis and transmission electron microscopy observation were performed to investigate a microstructural evolution and its influence on the hardening behavior in Fe-Cr alloys after an irradiation with 8 MeV Fe4+ ions at room temperature. Nano indentation analysis shows that an irradiation induced hardening is generated more considerably in the Fe-15Cr alloy than in the Fe-5Cr alloy by the ion irradiation. TEM observation reveals a significant population of the a0 dislocation loops in the Fe-15Cr alloy and an agglomeration of the 1/2a0 dislocation loops in the Fe-5Cr alloy. The results indicate that the a0 dislocation loops will act as stronger obstacles to a dislocation motion than 1/2a0 dislocation loops.

2008-11-01

452

Evaluation of induced radioactivity in 10 MeV-electron irradiated spices, (1)

It has recently been shown that the superconducting properties of Nb-base A-15 compounds, A_3B, are severely degraded when exposed to high-energy (E>1 MeV) neutron irradiation at ambient reactor temperatures. In each case, superconducting transition temperatures, Tsub(c), and the Bragg Williams order parameters, S, were observed to decrease steadily with irradiations in excess of 10"1"8 nvt. During irradiation the A-15 structure is retained and subsequent isothermal annealing restores almost completely the compound's original Tsub(c) value. In this letter a correlation between B atom diameter and the recovery rates of Tsub(c) for the irradiated materials Nb_3Ge, Nb_3Ga, Nb_3Al and Nb_3Sn is reported. (Auth.).

453

Detection of irradiated chicken by ESR spectroscopy of bone

Black pepper, white pepper, red pepper, ginger and turmeric were irradiated with 10 MeV electrons from a linear accelerator to a dose of 100 kGy and radioactivity was measured in order to estimate induced radioactivity in the irradiated foods. Induced radioactivity could not be detected significantly by #gamma#-ray spectrometry in the irradiated samples except for spiked samples which contain some photonuclear target nuclides in the list of photonuclear reactions which could produce radioactivity below 10 MeV. From the amount of observed radioactivities of short-lived photonuclear products in the spiked samples and calculation of H_5_0 according to ICRP Publication 30, it was concluded that the induced radioactivity and its biological effects in the 10 MeV electron-irradiated natural samples were negligible in comparison with natural radioactivity from "4"0K contained in the samples. (author).

454

Annual report of JMTR, 1994. April 1, 1994 - March 31, 1995

Ionizing radiation has been used to treat poultry to remove harmful microorganisms, mainly Salmonella, which contaminates chicken, goose and other fresh and frozen poultry. This microorganism is sensitive to low dose radiation. Thus, irradiating these foods with doses between 1 to 7 kGy results in a large reduction of bacteria. Since it is necessary to determine whether irradiation has occurred and to what extend, this work studied the signal produced by ionizing radiation within the hard crystalline matrix of chicken`s bone to establish a control method. Chicken`s drumsticks were irradiated and bones separated from flesh were lyophilized and milled. ESR spectrum was then obtained. The ESR signal increased linearly with dose over the range 0.25 to 8.0 kGy. Free radicals evaluated during 30 days after irradiation showed stable in this period. (Author).

1995-10-01

455

A note on neutron irradiation effects on transition temperature of A-15 superconducting materials

In FY1994, JMTR was in operation during 4 operation cycles with low enriched Uranium(LEU,20%) fuel for irradiation study of nuclear fuels and materials and for radioisotope production. Irradiation studies were carried out using capsules, Oarai Gas Loop-1(OGL-1), Oarai Shroud Facility(OSF-1) and hydraulic rabbits irradiation facilities in support of LWR, FBR, HTTR and thermonuclear reactor. Irradiation studies on blanket materials were intensively carried out. Power ramping tests were carried out and the future program is under consideration. For R and D works, neutron spectrum evaluation technology, re-instrumentation technique for irradiation fuel rod, remote controlled SEM apparatus and examination technique with miniaturized specimens were successfully developed. (author).

1996-03-01

456

The role of the mesenchyme in mouse neural fold elevation. II. Patterns of hyaluronate synthesis and distribution in embryos developing in vitro

The change of superconducting properties after neutron irradiation in A-15 compounds such as Nb_3Sn. Nb_3Al. V_3Ca and V_3Si has been examined. Using the model based on the damage function, the change of transition temperature corresponding to an arbitrary irradiation dose within about 10"2"0n/cm"2 can be predicted with an accuracy of several percent for Nb_3Al. Nb_3Sn and V_3Si if experimental data, namely a pair of irradiation dose and transition temperature, is given. The calculation of transition temperature of neutron irradiated A-15 compounds is much more straightforward than in the case of Pande's model. (author).

457

Manufacture of IRDye800CW-coupled Fe3O4 nanoparticles and their applications in cell labeling and in vivo imaging

Hyaluronate (HA) distribution patterns were examined in the cranial mesenchyme underlying the mesencephalic neural folds of mouse embryos maintained in roller tube culture. Using standard image-processing techniques, the digitized images of Alcian blue-stained or 3H-glucosamine-labeled sections digested with an enzyme specific for HA, were subtracted from adjacent, undigested sections. The resultant difference picture images (DPI) accurately depicted the distribution of stained or labeled HA within the cranial mesenchyme. 3H-glucosamine-labeled HA was distributed uniformly throughout the cranial mesenchyme as 12, 18, and 24 hr of culture. By contrast, the mesenchyme was uniformly stained with Alcian blue at 12 hr, but stain intensity decreased in the central regions of the mesenchyme at 18 and 24 hr. HA distribution patterns were also examined in the cranial mesenchyme of embryos cultured in the presence of diazo-oxo-norleucine (DON), a glutamine analogue that ...

1990-06-01

458

Experimental chemo- and radio-therapy on human cholangiocarcinoma transplanted to nude mice

BackgroundIn recent years, near-infrared fluorescence (NIRF)-labeled iron nanoparticles have been synthesized and applied in a number of applications, including the labeling of human cells for monitoring the engraftment process, imaging tumors, sensoring the in vivo molecular environment surrounding nanoparticles and tracing their in vivo biodistribution. These studies demonstrate that NIRF-labeled iron nanoparticles provide an efficient probe for cell labeling. Furthermore, the in vivo imaging studies show excellent performance of the NIR fluorophores. However, there is a limited selection of NIRF-labeled iron nanoparticles with an optimal wavelength for imaging around 800 nm, where tissue autofluorescence is minimal. Therefore, it is necessary to develop additional alternative NIRF-labeled iron nanoparticles for application in this area.ResultsThis study manufactured 12-nm DMSA-coated Fe3O4 nanoparticles labeled with a near-infrared fluorophore, IRDye800CW (excitation/emission, ...

2010-10-29

459

Evaluation of Beta-Absorbed Fractions in a Mouse Model for 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177Lu Radionuclides

A human cholangiocarcinoma, Ch-1, serially transplanted to nude mice was used for experimental chemotherapy, radiotherapy, and conbination chemoradiotherapy. In the group of chemotherapy with single drug, Mitomycin C (MMC) revealed greater effectiveness than Adriamycin in terms of tumor regression, histological findings, and minor side effects. MMC and radiotherapy by Linac X-ray showed exponential linear dose response curve against tumor weight. Their effects were equivalent at doses of MMC 1 mg/kg and radiation 1,000 rads/mouse in the changes of tumor weight and of histological findings which were similar to each other. Combination chemoradiotherapy showed the synergistic action when the radiation (500 rads/mouse) was performed before MMC (0.5 mg/kg) administration, whereas only the additive effect was observed when the sequence was reversed. The cell kinetic analysis was performed by the impulse cytophotometry, "3H-thymidine uptake labeling ...

460

Comparative tissue distribution and excretion of orally administered ["3H]diacetoxyscirpenol (anguidine) in rats and mice

Several short-lived, high-energy beta emitters are being proposed as the radionuclide components for molecular-targeted potential cancer therapeutic agents. The laboratory mice used to determine the efficacy of these new agents have organs that are relatively small compared to the ranges of these high-energy particles. The dosimetry model developed by Hui et al. was extended to provide realistic beta-dose estimates for organs in mice that received therapeutic radiopharmaceuticals containing 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177 Lu. Major organs in this model included the liver, spleen, kidneys, lungs, heart, stomach, small and large bowel, thyroid, pancreas, bone, marrow, carcass, and a 0.025-g tumor. The study as reported in this paper verifies their results for 90Y and extends them by using their organ geometry factors combined with newly calculated organ self-absorbed fractions from PEREGRINE and MCNP. PEREGRINE and MCNP agree to within 8% for the worst-case organ with average ...

2005-08-01

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461

A high-sensitivity small animal SPECT system

A quantitative comparison of tissue distribution and excretion of an orally administered sublethal dose of [3H]diacetoxyscirpenol (anguidine) was made in rats and mice 90 min, 24 hr, and 7 days after treatment. Total recoveries of 95-100% were obtained. Approximately 90% of the dose was excreted in urine and feces during the first 24 hr with a feces:urine ratio of about 1:4.5 in both species. Carcass and tissue radioactivity dropped rapidly during the first 24 hr but remained relatively constant at low, but detectable, levels over the course of the experiment. Few substantive interspecies differences were noted in tissue distribution. At 90 min the highest percentage of dose was in tissues involved in sequestering diacetoxyscirpenol because of high body water/lipid content or the absorption, metabolism, or excretion of the toxin. The rank order of these tissues was generally stable over the course of the experiment. When data were expressed as specific radioactivity instead, the ...

462

Use of gamma irradiation for microbial inactivation of buckwheat flour and buckwheat food products, 6

Medical imaging using single gamma-ray-emitting radionuclides typically makes use of parallel hole collimators or pinholes in order to achieve good spatial resolution. However, a tradeoff in sensitivity is inherent in the use of a collimator, and modern preclinical single photon emission computed tomography (SPECT) systems detect a very small fraction of emitted gamma rays, often less than 0.1%. A system for small animal SPECT imaging which uses no collimators could potentially achieve very high sensitivity-several tens of percent-with reasonably sized detectors. This would allow two significant improvements in preclinical studies: images could be obtained more rapidly, allowing higher throughput for screening applications, or for dynamic processes to be observed with very good time resolution; and images could be obtained with less radioactive tracer, making possible the in vivo imaging of low-capacity receptor systems, aiding research into new tracer compounds, and reducing the cost ...

2009-03-07

463

Development of an irradiation system for a small size continuous run multipurpose gamma irradiator

The effects of gamma irradiation at 0.2#approx#0.4 Mrad and condition for processing of buckwheat noodles on sensory quality and physical properties were investigated. The results were as follows: (1) Sensory evaluation of buckwheat noodles, prepared with the 70 % ratio of buckwheat flour, was decreased according to an increase of irradiation dose of buckwheat flour. Hardness and adhesiveness of buckwheat noodles caused by irradiation should be given large effect to the texture. Elasticity of buckwheat noodles was linearly decreased with increasing of irradiation dose of buckwheat flour, and elasticity of buckwheat noodles was decreased about 15 % by an increase of irradiation dose at 0.3 Mrad. (2) Maximum torque in Farinograph test was linearly decreased with increasing of irradiation dose of buckwheat flour, and maximum torque was decreased about 3 % by ...

1989-01-01

464

Determination of volatiles produced during radiation processing in food and medicinal herbs; Determinacao de volateis produzidos durante o processamento por radiacao em ervas alimenticias e medicinais

The Radiation Technology Center from IPEN-CNEN/SP, Brazil, developed a revolutionary design and national technology, a small-sized continuous run and multipurpose industrial gamma irradiator, to be used as a demonstration facility for manufacturers and contract service companies, which need economical and logistical in-house irradiation system alternatives. Also, to be useful for supporting the local scientific community on development of products and process using gamma radiation, assisting the traditional and potential users on process validation, training and qualification of operators and radioprotection officers. The developed technology for this facility consists of a continuous tote box transport system, comprising a single concrete vault, where the automated transport system of products inside and outside of the irradiator utilizes a rotating door, integrated with the shielding, avoiding the traditional maze ...

465

WHO wants more use of irradiated food, calls for education programs

In order to protect food from pathogenic microorganisms as well as to increase its shelf life while keeping sensorial properties (e.g. odor and taste), once the latter are one of the main properties required by spice buyers, it is necessary to analyze volatile formation from irradiation of medicinal and food herbs. The aim of the present study was to analyze volatile formation from Co irradiation of Laurus Cinnamomum, Piper Nigrum, Origanum Vulgare and Myristica Fragans. Possible changes on the odor of these herbs are evaluated by characterizing different radiation doses and effects on sensorial properties in order to allow better application of irradiation technology. l he samples have been irradiated in plastic packages by making use of a {sup 60}Co Gamma irradiator. Irradiation doses of 0, 5, 10, 15, 20 and 25kGy have been tested. For the analysis of the ...

2008-07-01

466

Ultrastructural effect of gamma radiation on grass shrimps (Penaeus monodon Fabricius)

Short note. The World Health Organization (WHO) has taken aim at critics of irradiated food, claiming that the process has the potential to reduce the incidence of foodborne diseases such as salmonellosis, to cut postharvest food losses and to provide a wider variety of foods for consumers. 'The unwarranted rejection of this process, often based on lack of understanding of what food irradiation entails, may hamper its use in those countries which may benefit most', Dr. Jean-Paul Jardel, WHO's assistant director-general, argued following a recent international conference on the subject. Critics, including Canadians, has opposed food irradiation for years, claiming that more needs to be known about its effects. WHO said the 'vast majority' of the 54 national delegations at the conference supported use of the technology on foods ranging from grain and potatoes to poultry, tropical fruit and strawberries. WHO wants governments ...

1989-02-01

467

Ultrastructural effect of gamma radiation on grass shrimps (Penaeus monodon Fabricius)

The effect of ionizing radiation (2, 5, and 10 KGy of gamma rays) on muscle ultrastructure of grass shrimps (Penaeus monodon Fabricius) tails at ambient or frozen (-18{sup 0}C) temperature was investigated by transmission electron microscopy (TEM). No significant change was found in muscle ultrastructure of shrimp meat irradiated at doses of 2 or 5 KGy and then stored at 4{sup 0}C for 0 and 8 days. However, in shrimps which were irradiated at ambient temperature at a dose of 10 KGy, the margin of A-band of the myofibrils in longitudinal sections exhibited an irregular zig-zag pattern. In cross section some myosin filaments in the A-band regions were missing. A possible interpretation of these results would be that 10 KGy gamma irradiation dose at ambient temperature depolymerized myosin in the A-band from the tail of thick filament. Actin damage was also observed in some cross sections. Irradiation ...

1990-01-01

468

The fading of irradiated blue-colored pearls

The effect of ionizing radiation (2, 5, and 10 KGy of gamma rays) on muscle ultrastructure of grass shrimps (Penaeus monodon Fabricius) tails at ambient or frozen (-18"0C) temperature was investigated by transmission electron microscopy (TEM). No significant change was found in muscle ultrastructure of shrimp meat irradiated at doses of 2 or 5 KGy and then stored at 4"0C for 0 and 8 days. However, in shrimps which were irradiated at ambient temperature at a dose of 10 KGy, the margin of A-band of the myofibrils in longitudinal sections exhibited an irregular zig-zag pattern. In cross section some myosin filaments in the A-band regions were missing. A possible interpretation of these results would be that 10 KGy gamma irradiation dose at ambient temperature depolymerized myosin in the A-band from the tail of thick filament. Actin damage was also observed in some cross sections. Irradiation damage of ...

469

Initial stage of localized corrosion in artificial pits formed with photon rupture on Zn-5 mass% Al alloy-coated steel

The fading of irradiated and natural blue-colored pearls was investigated in this experiment. Thirty natural blue-colored pearls and sixty irradiated blue-colored pearls were used. Some of them were placed at a light position of RT. Another pearls were placed at a dark position of 50"0C. The irradiated pearls placed at a light position of RT didn't show remarkable fading in their color in 294 days. But the natural blue-colored pearls showed a little recovery from 4% to 8% in reflection factors in 223 days at RT. The irradiated pearls placed at a dark position of 50"0C showed the recovery from 9% to 14% in 264 days independently of irradiation times. The natural blue-colored pearls also showed the bleaching from 5% to 10% in reflection factor in 86 days at 50"0C. Both irradiated and natural blue-colored pearls hardly showed their remarkable changes in their ...

470

Fading of irradiated blue-colored pearls. [Gamma radiation

The photon rupture method, by which oxide film and metal are removed by focused pulsed Nd-YAG laser beam irradiation, was applied to form artificial micro-pits in Zn-5 mass% Al alloy-coated steel. The zinc alloy-coated layer was removed by pulsed laser irradiation treatment for about one second in a neutral buffer solution with NaCl. The rest potential transient with the laser treatment was measured. In the early stage of the laser treatment the rest potential of zinc alloy-coated steel changed to the negative direction immediately after every irradiation of a laser pulse and then returned to the previous value. However, after the steel substrate was exposed to the solution, the rest potential moved to the positive direction immediately after every irradiation of a laser pulse and then returned to the previous value. The amplitude and duration of the potential change after the laser ...

2007-05-01

471

Evaluation of Mechanical Properties and Microstructure in Ion-Irradiated Surface Layer

The fading of irradiated and natural blue-colored pearls was investigated in this experiment. Thirty natural blue-colored pearls and sixty irradiated blue-colored pearls were used. Some of them were placed at a light position of RT. Another pearls were placed at a dark position of 50/sup 0/C. The irradiated pearls placed at a light position of RT didn't show remarkable fading in their color in 294 days. But the natural blue-colored pearls showed a little recovery from 4% to 8% in reflection factors in 223 days at RT. The irradiated pearls placed at a dark position of 50/sup 0/C showed the recovery from 9% to 14% in 264 days independently of irradiation times. The natural blue-colored pearls also showed the bleaching from 5% to 10% in reflection factor in 86 days at 50/sup 0/C. Both irradiated and natural blue-colored pearls hardly showed their ...

1982-03-01

472

Effects of multi-ion irradiation on microstructural changes in lithium titanate

Target vessel materials used in spallation neutron source will be exposed to proton and neutron irradiation and mercury immersion environments. In order to evaluate the surface degradation of the vessel candidate materials due to such environment, the triple-ion beam irradiation taking the spallation reaction into account and mercury immersion tests were carried out. Mechanical properties of the gradient surface layer were evaluated by the inverse analysis with multi-layer model that considers distribution of surface characteristic was applied to the load and depth curves measured by using the instrumented indentation machine. Transmission electron microscopic observations were performed to evaluate the changes of microstructure in irradiated surface layer using focused ion-beam cut micro-specimen. The mechanical properties distributions in the surface layer were evaluated quantitatively and the changes in microstructures ...

2005-01-01

473

Effects of multi-ion irradiation on microstructural changes in lithium titanate

The irradiation behavior of Li{sub 2}TiO{sub 3} under a fusion reactor environment was simulated by simultaneous irradiation of Li{sub 2}TiO{sub 3} by the triple ion beams and the respective single ion beams of O{sup 2+}, He{sup +} and H{sup +}. The microstructural changes in Li{sub 2}TiO{sub 3} caused by the irradiation were measured by FT-IR photoacoustic spectroscopy. The results suggest that the amount of TiO{sub 2} formed is proportional to the dpa and that the method of irradiation does not affect the dependence of formation of TiO{sub 2}. On the other hand, the amount of defects and/or radiolytic products generated by irradiation, which is considered to trap hydrogen near the surface, is found to be affected by the method of irradiation. Such phenomena are believed to affect the tritium release behavior from Li{sub 2}TiO{sub 3}, and durability of Li{sub ...

2009-04-30

474

Effect of helium implantation on the mechanical properties and the microstructure of the martensitic 12% Cr-steel 1. 4914

The irradiation behavior of Li_2TiO_3 under a fusion reactor environment was simulated by simultaneous irradiation of Li_2TiO_3 by the triple ion beams and the respective single ion beams of O"2"+, He"+ and H"+. The microstructural changes in Li_2TiO_3 caused by the irradiation were measured by FT-IR photoacoustic spectroscopy. The results suggest that the amount of TiO_2 formed is proportional to the dpa and that the method of irradiation does not affect the dependence of formation of TiO_2. On the other hand, the amount of defects and/or radiolytic products generated by irradiation, which is considered to trap hydrogen near the surface, is found to be affected by the method of irradiation. Such phenomena are believed to affect the tritium release behavior from Li_2TiO_3, and durability of Li_2TiO_3 and compatibility of Li_2TiO_3 with other components of the ...

2009-04-30

475

Application of the microbiological method DEFT/APC to detect minimally processed vegetables treated with gamma radiation

Tensile specimens of the normalized and tempered fully martensitic steel DIN 1.4914 were helium implanted up to 340 appm within the temperature range 300-720/sup 0/C using a 104 MeV alpha particle beam. The high He/damage ratio of 1850 appm He/dpa allowed to determine the effect of helium on material properties. After irradiation tensile strength and ductility were investigated mainly at test temperatures equal to the irradiation temperatures. While short time irradiations with helium contents up to 100 appm have shown no visible effect on the tensile behaviour at all temperatures investigated, long time irradiations reduced the material strength at irradiation temperatures above about 440/sup 0/C. This irradiation induced softening obscured the predicted minor hardening effect of the observed He-bubbles completely and increases with ...

1988-07-01

476

Use of polarized light microscopy in porcine reproductive technologies

Marketing of minimally processed vegetables (MPV) are gaining impetus due to its convenience, freshness and apparent health effect. However, minimal processing does not reduce pathogenic microorganisms to safe levels. Food irradiation is used to extend the shelf life and to inactivate food-borne pathogens. In combination with minimal processing it could improve safety and quality of MPV. A microbiological screening method based on the use of direct epifluorescent filter technique (DEFT) and aerobic plate count (APC) has been established for the detection of irradiated foodstuffs. The aim of this study was to evaluate the applicability of this technique in detecting MPV irradiation. Samples from retail markets were irradiated with 0.5 and 1.0 kGy using a {sup 60}Co facility. In general, with a dose increment, DEFT counts remained similar independent of the irradiation while APC ...

2009-07-15

477

British Library Electronic Table of Contents (United Kingdom)

The meiotic spindle in the oocyte is composed of microtubules and plays an important role during chromosome alignment and separation at meiosis. Polarized light microscopy (PLM) could be useful for a non-invasive evaluation of the meiotic spindle and may allow removal of nuclear structures without fluorochrome staining and ultraviolet exposure. In this study, PLM was used to assess its potential application in porcine reproductive technologies. The objectives of the present study were to assess the efficiency of PLM to detect microtubule-polymerized protein in in vitro-matured porcine oocytes; to examine its effects on the oocyte developmental competence; to select oocytes based on the presence of the meiotic spindle detected by PLM; and to assess the efficiency oocyte enucleation assisted...

2011-01-01

478

Upper bound for a three-photon excitation cross section in atomic argon in the ultraviolet regime

UV inactivation: Combined effects of UV radiation and xenobiotics in two strains of Saccharomyces

A scheme of evaluating a generalized three-photon excitation cross section #sigma#/sub (3)/ in neutral atomic argon at 3144.67 A is outlined. Three photons at this wavelength can excite the neutral argon atoms from the ground 3p"6 "1S_0 state to the 3p"54s'[1/2]_1"0 state. The fourth photon will ionize the argon atoms. Assuming linear polarization of the incident laser radiation, contributions from several channels in various energy-level schemes are summed in the evaluation of the transition probability. For a laser linewidth of #DELTA##lambda#/sub L/ = 1 A, our maximum numerical value of the computed result for the three-photon excitation cross section is #sigma#/sub (3)/ = 1.414 x 10/sup -80/ cm"6 s"2. .AE.

8800-01-01

479

Stabilizing effect of the electron-beam self-fields on the phase-space trajectory in a self-amplified spontaneous emission free-electron laser operating in ultraviolet and x-ray spectral ranges

The effects of eight chemicals on the inactivation rate of ultraviolet radiation on the colony building capabilities of two strains of Saccharomyces cervisae - a wild type strain and a mutant deficient in excision repair - were studied. The insecticide methoxychlor, the herbicide 2,4-dichlorophenoxyacetic acid, the fungicide pentachlorophenol and its metabolite tetrachlorohydroquinone, as well as the chemicals acrylonitrile and 2,3-dichloro-1-propene have no significant impact on the effects of UV radiation in Saccharomyces cerevisae. Depending on the concentration, trichloroethylene increases the sensitivity to UV radiation. The herbicide paraquat provides efficient protection against UV radiation at concentrations where a toxic effect cannot be observed even without UV. The results were rather similar for both strains. (orig.).

480

Positive effects of UV radiation on a calanoid copepod in a transparent lake: do competition, predation or food availability play a role?

A detailed treatment is introduced to measure the dynamic stability of the relativistic electrons in a self-amplified spontaneous emission free-electron laser (FEL) system, which includes the numerical approach of the Kolmogorov entropy (entropy-like quantity), the general equations of motion for a charged particle and the method of monitoring the simulation accuracy. Numerical experiments reveal a new phenomenon that there exists the possibility of the transition from chaotic to non-chaotic phase-space trajectories of the strongly relativistic electrons due to the effect of their self-fields. The adiabatic magnetic field of a one-dimensional wiggler may have a slight influence on the electron transportation in the absence of the FEL fields, but substantially affects the dynamic stability of the electrons in the process of the FEL interaction. Moreover, the laser fields diminish the dynamic stability of the electrons as the FEL interaction grows exponentially.

2004-02-28

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481

British Library Electronic Table of Contents (United Kingdom)

Zooplankton tolerant to ultraviolet radiation (UVR) could be indirectly affected by UVR through interactions with UV-sensitive species in the same ecosystem. In Lake Giles, Pennsylvania, USA, the calanoid copepod Leptodiaptomus minutus is more UVR tolerant than the cohabiting species Daphnia catawba and Cyclops scutifer. We asked whether L. minutus is affected by UV-induced mortality of a food competitor (D. catawba) or a predator of its nauplii (C. scutifer). We conducted two in situ enclosure experiments with six treatments: L. minutus alone, L . minutus + Daphnia and L. minutus + Cyclops in the presence and absence of UVR. There were few differences in survival among treatments in Experiment 1, which had enhanced food and a cumulative UVR (320 nm) dose of 9.3 kJ m-2. In Experiment 2, wh...

2006-01-01

482

Photohemolytic potency of tetracyclines

Low temperature deposition and characterization of TiO{sub 2} photocatalytic film through cold spray

Hemolysis induced by long-wave ultraviolet radiation (UVA) and 8 different commercial tetracycline derivatives was studied in a model using human red blood cells. Demethylchlortetracycline and doxycycline were shown to have pronounced hemolytic properties causing 88% and 85% hemolysis, respectively, at a concentration of 50 micrograms/ml and 72 J/ cm2 of UVA. Tetracycline, oxytetracycline, and chlortetracycline caused maximally 18% hemolysis at 200 micrograms/ml and lymecycline only 7% at 100 micrograms/ml. Methacycline showed intermediate hemolytic effect of 36% at 200 micrograms/ml. Minocycline had no hemolytic effect whatsoever. These experimental data correlate very well with clinical reports and comparative phototoxicity trials in humans. Photohemolysis may thus be of value for predicting tetracycline phototoxicity.

1985-04-01

483

Kinetics of the methylparathion hydrolysis in aqueous medium; Cinetica de la hidrolisis del metilparation en medio acuoso

Cold spray was employed as a novel low temperature approach to deposit titanium dioxide (TiO{sub 2}) photocatalytic film. The film microstructure was characterized using X-ray diffraction and scanning electron microscopy. The photocatalytic performance was examined through acetaldehyde degradation under ultraviolet illumination. Results showed that TiO{sub 2} film was successfully deposited on substrate surface through cold spray. The film thickness reached up to 15 {mu}m. The film presented a rough surface and porous structure. Owing to the low temperature of spray powder, no phase and particle size changes occurred to TiO{sub 2} during deposition. It was found that the cold-sprayed TiO{sub 2} film was active for photodegradation of acetaldehyde.

2008-04-30

484

Investigating the Ultraviolet Properties of Gravity with a Wilsonian Renormalization Group Equation

The kinetics of alkaline hydrolysis of methylparathion was studied at different temperatures (0-50 Centigrade) in the p H range of 8-12 by ultraviolet-visible absorption spectroscopy. Optimum p H and wavelength conditions were defined to carry out the simultaneous determination of methylparathion and one of its hydrolysis product, paranitrophenol, in buffered aqueous medium. Based on the experimental data and the mathematical equation of the kinetics, a rate constant (k) of first-order and an activation energy (Ea) of 9.2 Kcal/mol, were estimated. (Author) activation energy (Ea) of 9.2 Kcal/mol, were estimated. (Author)

1997-12-31

485

Intrinsic fluorescence of the amniotic fluid

We review and extend in several directions recent results on the asymptotic safety approach to quantum gravity. The central issue in this approach is the search of a Fixed Point having suitable properties, and the tool that is used is a type of Wilsonian renormalization group equation. We begin by discussing various cutoff schemes, i.e. ways of implementing the Wilsonian cutoff procedure. We compare the beta functions of the gravitational couplings obtained with different schemes, studying first the contribution of matter fields and then the so-called Einstein-Hilbert truncation, where only the cosmological constant and Newton's constant are retained. In this context we make connection with old results, in particular we reproduce the results of the epsilon expansion and the perturbative one loop divergences. We then apply the Renormalization Group to higher derivative gravity. In the case of a general action quadratic in curvature we recover, within certain approximations, the known ...

2008-01-01

486

Green synthesis of iron nanoparticles and their application as a Fenton-like catalyst for the degradation of aqueous cationic and anionic dyes

The intrinsic fluorescence of clear amniotic fluid from third-trimester pregnancy is reported. The fluorescence intensity peaked at 405 nm when excited by ultraviolet light in the range of 310 to 360 nm. All of the 33 samples tested fluoresced, and their emission spectrum had the same shape, varying only in magnitude. Changing sample temperature (20 to 50 C) and sample pH (7.2 to 7.7) had little effect on the emission spectrum. The same fluorescence, with higher intensity, was observed when some newborn urine was tested. The fluorescence of amniotic fluid may provide a new tool to determine fetal age, fetal organ maturation, and fetal distress. (author).

1981-01-01

487

British Library Electronic Table of Contents (United Kingdom)

Iron nanoparticles were produced using extracts of green tea leaves (GT-Fe NPs). The materials were characterized using TEM, SEM/EDX, XPS, XRD, and FTIR techniques and were shown to contain mainly iron oxide and iron oxohydroxide. The obtained nanoparticles were then utilized as a Fenton-like catalyst for decolorization of aqueous solutions containing methylene blue (MB) and methyl orange (MO) dyes. The related experiments investigated the removal kinetics and the effect of concentration for both MB and MO. The concentrations of dyes in aqueous solution were monitored using ultraviolet-visible (UV-vis) spectroscopy. The results indicated fast removal of the dyes with the kinetic data of MB following a second order removal rate, while those of MO were closer to a first order removal rate. T...

2011-01-01

488

Determination of molar extinction coefficients #epsilon#_m(Ce"4"+) of Ce"4"+-Ce"3"+ dosimetric system

Design considerations for the magnetic system of a prototype x-ray free electron laser

#epsilon#_m(Ce"4"+) values of the ceric-cereus system have been measured and the experimental procedure is described. Both routine titration method and electrochemical measurement were used. Some interference factors, such as ultraviolet, acidity and temperature, were studied as well. The temperature coefficient of #epsilon#_m(Ce"4"+) value in this experiment is about -0.1% degree C"-"1. A statistic analysis was made for 24 experimental values of #epsilon#_m(Ce"4"+) and a Gaussian distribution was found. Ultimately, an average molar extinction coefficient of 553.2 +- 1.3 m"2#centre dot#mol"-"1 was obtained at #approx#320 nm in 0.4 mol/L H_2SO_4 system, with a relative standard deviation of 0.24% (95% confidence level) and a total uncertainty of 1.5%.

1996-01-01

489

Conceptual design of industrial free electron laser using superconducting accelerator

A number of difficult technical challenges need to be solved in the fields of accelerator and free-electron laser (FEL) technologies in order to build an X-ray FEL. One of the tasks well suited to the Advanced Photon Source Low Energy Undulator Test Line (LEUTL) is to take the intermediate step of solving some of the problems of single-pass FEL operation in the ultraviolet range. The existing Advanced Photon Source (APS) linac, in addition to its role of supply positrons for the APS storage ring, will also be used to generate the particle beam for the LEUTL. Here, the design of the magnetic system for the high gain soft x-ray free electron laser is described.

1997-04-01

490

Clinical and experimental studies of octocrylene's allergenic potency

Paper presents conceptual design of free electron laser (FEL) complex for industrial applications. The FEL complex consists of three. FEL oscillators with the optical output spanning the infrared (IR) and ultraviolet (UV) wave-lengths (#lambda# = 0.3...20 #mu#m) and with the average output power 10 - 20 kW. The driving beam for the FELs is produced by a superconducting accelerator. The electron beam is transported to the FELs via three beam lines (125 MeV and 2 x 250 MeV). Peculiar feature of the proposed complex is a high efficiency of the. FEL oscillators, up to 20 %. This becomes possible due to the use of quasi-continuous electron beam and the use of the time-dependent undulator tapering.

1995-08-21

491

British Library Electronic Table of Contents (United Kingdom)

Background. Reports of positive patch test and photopatch test reactions to the chemical ultraviolet filter octocrylene have increased during the last decade. Little is known about the reason for octocrylene's allergenic activity. Objectives. To present and discuss the results of patch tests and photopatch tests with octocrylene, and to investigate the possible cause of its allergenic properties. Methods. Results of patch tests and photopatch tests with octocrylene in patients with adverse skin reactions to sunscreen products and/or ketoprofen were collected. The allergenic potency of octocrylene was investigated in the murine local lymph node assay (LLNA). Chemical reactivity assays were used to mimic octocrylene's interaction with biomolecules. Results. We report 23 cases of positive tes...

2011-01-01

492

Chemical transformations of organic matter during the composting of wood industry wastes (residues); Transformacoes quimicas da materia organica durante a compostagem de residuos da industria madeireira

Broad-linewidth laser absorption measurements of oxygen between 211 and 235nm at high temperatures

Composting of sawdust and paper mill sludge, using a 'Kneer' process reactor, was studied in an attempt to elaborate upon organic matter transformation during the process and to define parameters to measure the compost maturity level. Temperature, electron paramagnetic resonance data, ash and C, H, N and S contents, and a spectroscopic method using ultraviolet-visible (UV-VIS) for alkaline (pH = 8.5) and solid samples was used to study the maturity of the compost samples. These parameters were measured in 6 humic acids extracted from the compost samples during 29 days. The results of this work show that the 'Kneer' process is efficient in transforming ligno-celulitic residues in a short time (29 days), into an organic fertilizer material with application perspectives (author)

2004-06-01

493

British Library Electronic Table of Contents (United Kingdom)

Absorption coefficient data are presented for molecular oxygen at temperatures between 1100 and 2000K and discrete wavelengths between 211 and 235nm. Measurements were made behind reflected shock waves using broad-linewidth ultraviolet laser radiation generated from a frequency-quadrupled, tunable, pulsed Ti:Sapphire laser. Test mixtures consisting of 15% O"2, 15% He and balance Ar were used to minimize the influence of vibrational relaxation on the reflected shock temperature. The experimental results are in good agreement with theoretical calculations and confirm that discrete features from the Schumann-Runge system dominate between 211 and 235nm at temperatures higher than 1100K.

2011-01-01

494

Asphalt emulsion sealing of uranium mill tailings. 1980 annual report

Application of asphalt emulsion seals to uranium mill tailings

Studies of asphalt emulsion sealants conducted by the Pacific Northwest Laboratory have demonstrated that the sealants are effective in containing radon and other potentially hazardous material within uranium tailings. The laboratory and field studies have further demonstrated that radon exhalation from uranium tailings piles can be reduced by greater than 99% to near background levels. Field tests at the tailings pile in Grand Junction, Colorado, confirmed that an 8-cm admix seal containing 22 wt% asphalt could be effectively applied with a cold-mix paver. Other techniques were successfully tested, including a soil stabilizer and a hot, rubberized asphalt seal that was applied with a distributor truck. After the seals were applied and compacted, overburden was applied over the seal to protect the seal from ultraviolet degradation.

495

Anisotropic forming of magnetic powders mixed with ultraviolet resin; Shigaisen koka jushi wo mochiita jisei funmatsu no haiko seikei

Studies of asphalt emulsion sealants have demonstrated that the sealants are effective in containing radon and other potentially hazardous material within uranium tailings. The laboratory and field studies have further demonstrated that radon exhalation from uranium tailings piles can be reduced by greater than 99% to less than background levels. Field tests at the tailings pile in Grand Junction, Colorado confirmed that an 8-cm admix seal containing 22 wt % asphalt could be effectively applied with a cold-mix paver. Other techniques were successfully tested, including a soil stabilizer and a hot, rubberized asphalt seal that was applied with a distributor truck. After the seals were applied and conpacted, overburden was applied over the seal to protect the seal from ultraviolet degradation. 14 figures.

496