ultrastructural cytotoxic effects: Topics by WorldWideScience.org

A congenital lethal form of hypophosphatasia: histologic and ultrastructural study.

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2007-10-01

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Ultrastructural effect of gamma radiation on grass shrimps (Penaeus monodon Fabricius)

PMID:8677780

1996-05-01

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Ultrastructural effect of gamma radiation on grass shrimps (Penaeus monodon Fabricius)

The effect of ionizing radiation (2, 5, and 10 KGy of gamma rays) on muscle ultrastructure of grass shrimps (Penaeus monodon Fabricius) tails at ambient or frozen (-18{sup 0}C) temperature was investigated by transmission electron microscopy (TEM). No significant change was found in muscle ultrastructure of shrimp meat irradiated at doses of 2 or 5 KGy and then stored at 4{sup 0}C for 0 and 8 days. However, in shrimps which were irradiated at ambient temperature at a dose of 10 KGy, the margin of A-band of the myofibrils in longitudinal sections exhibited an irregular zig-zag pattern. In cross section some myosin filaments in the A-band regions were missing. A possible interpretation of these results would be that 10 KGy gamma irradiation dose at ambient temperature depolymerized myosin in the A-band from the tail of thick filament. Actin damage was also observed in some cross sections. Irradiation damage of sarcoplasmic ...

1990-01-01

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Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells

The effect of ionizing radiation (2, 5, and 10 KGy of gamma rays) on muscle ultrastructure of grass shrimps (Penaeus monodon Fabricius) tails at ambient or frozen (-18"0C) temperature was investigated by transmission electron microscopy (TEM). No significant change was found in muscle ultrastructure of shrimp meat irradiated at doses of 2 or 5 KGy and then stored at 4"0C for 0 and 8 days. However, in shrimps which were irradiated at ambient temperature at a dose of 10 KGy, the margin of A-band of the myofibrils in longitudinal sections exhibited an irregular zig-zag pattern. In cross section some myosin filaments in the A-band regions were missing. A possible interpretation of these results would be that 10 KGy gamma irradiation dose at ambient temperature depolymerized myosin in the A-band from the tail of thick filament. Actin damage was also observed in some cross sections. Irradiation damage of sarcoplasmic membranes ...

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Nickel induced structural and functional alterations in mouse Leydig cells in vitro

The temporal development of the effect of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) on the ultrastructure composition and GABA receptor expression in cerebellar granule cells was investigated by quantitative electron microscopy (morphometric analysis) and GABA binding assays. It was found that the cytoplasmic density of smooth endoplasmic reticulum was decreased, while the cytoplasmic density of rough endoplasmic reticulum, Golgi apparatus, vesicles and coated vesicles was greatly enhanced after exposure of the cells to THIP (150 microM) for only 1 hr. In cerebellar granule cells exposed to THIP (150 microM) for 3 hr low affinity GABA receptors were induced. These findings show that the effect of THIP on the ultrastructure composition and GABA receptor expression in cultured cerebellar granule cells may be interrelated and moreover it is likely that the turn-over of GABA receptors is ...

1987-01-01

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British Library Electronic Table of Contents (United Kingdom)

The present study was aimed at investigating effects of nickel (NiCl2) on secretion of testosterone (T), cell viability, ultrastructure and apoptosis in mouse Leydig cells. Testosterone release was measured after 48h of culture with 15.67, 31.25, 62.5, 125, 250, 500 and 1000mmol/L NiCl2 or without NiCl2 using radioimmunoassay. Cell viability was assessed by a MTT (metabolic activity assay). Quantification of apoptotic cells was performed using TUNEL assay and the ultrastructural changes were analyzed using transmission electron microscopy. The viability was decreased after addition of >=250mmol/L NiCl2. A concentration-dependent depression of T production was observed. The percentage of apoptotic cells was significantly increased only after addition of 125, 250 and 1000mmol/L NiCl2. After ...

2011-01-01

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B chain is a functional subunit of beta-bungarotoxin for inducing apoptotic death of human neuroblastoma SK-N-SH cells.

The ultrastructure of conjunctival melanocytic tumors.

beta-Bungarotoxin (beta-Bgt), a presynaptic phospholipase A(2) (PLA(2)) neurotoxin isolated from the venom of Bungarus multicinctus, consists of A chain and B chain. The goal of the present study is to explore the functional contribution of the two subunits to the toxicity of beta-Bgt. beta-Bgt was found to induce apoptotic death of SK-N-SH cells via elevating intracellular Ca(2+) and intracellular ROS production. Moreover, an activation of p38 MAPK was associated with the cytotoxicity of beta-Bgt. SB202190 (p38 MAPK inhibitor), N-acetylcysteine (antioxidant reagent), 1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid (BAPTA) (Ca(2+) chelator) and the inhibitors of Ca(2+) release from intracellular depots (ruthenium red and 2-aminoethoxydiphenyl borate) effectively attenuated the cytotoxicity of beta-Bgt. In sharp contrast to the inability of A chain, B chain was able to induce cytotoxic ...

2007-10-13

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Activation of Cytotoxic and Regulatory Functions of NK Cells by Sindbis Viral Vectors

The ultrastructure of conjunctival melanocytic lesions in 49 patients was evaluated to find significant differences between benign and malignant cells. The patients studied included 9 with benign epithelial...Full Text Available

1984-01-01

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Low cytotoxicity effect of dendrosome as an efficient carrier for rotavirus VP2 gene transferring into a human lung cell line

Oncolytic viruses (OVs) represent a relatively novel anti-cancer modality. Like other new cancer treatments, effective OV therapy will likely require combination with conventional treatments. In order...Full Text Available

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British Library Electronic Table of Contents (United Kingdom)

The efficiency of dendrosome (a gene porter) was assessed in transferring recombinant human rotavirus VP2 cDNA into A549, a human lung cell line. After gene transferring, transmission electron microscopy showed core-like particles (CLPs) formation in the transfected cells both with dendrosome and lipofectamine porters. In addition, western blotting analysis showed that the expression of VP2 gene was almost equal in the dendrosome and lipofectamine-transfected cells. Also, the cytotoxicity studies revealed that dendrosome had a lower cytotoxicity than lipofectamine. Therefore, our study may introduce dendrosome as a possible carrier for gene transferring into the human lung cell line, especially, for intranasally administration of DNA vaccines.

2009-01-01

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Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin.

Genetical approach to oxygen toxicity. [Saccharomyces cerevisiae

Pancreatic amyloid deposits of amylin are a hallmark of Type II diabetes and considerable evidence indicates that amylin oligomers are cytotoxic to beta-cells. Many efforts are presently spent to find out naturally occurring molecules, or to design synthetic ones, able to hinder amylin aggregation or to protect cells against aggregate cytotoxicity. In this context, a protective effect of some polyphenols against amyloid cytotoxicity was reported. Actually dietary polyphenols are endowed with multiple health benefits, and extra virgin olive oil is attracting increasing interest as a source of these substances. Here, we investigated the effects on amylin aggregation and cytotoxicity of the secoiridoid oleuropein aglycon, the main phenolic component of extra virgin olive oil. We found that oleuropein, when present during the aggregation of amylin, consistently ...

2009-07-18

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Cytotoxic Sesquiterpenoid from the Seeds of Amomum xanthioides

The role of intermediate products of dioxygen reduction in cytotoxic effects ascribed to oxygen molecules was studied in vivo using various yeast mutants with changed response to oxygen stress. It has been documented that superoxide radical exerts its deleterious effects on yeast cells directly and the role of other oxygen species derived from it is hardly detectable. Yeast Saccharomyces cerevisiae, however, cannot be considered as a typical eukaryotic organism due to its inability of synthesizing polyunsaturated fatty acids (pufa). These fatty acids are known as main target molecules during oxidative stress and their peroxidation leads to cytotoxic effects. As fatty acid content could be easily manipulated in yeast, this organism was used to evaluate the contribution of pufa peroxidation process to the cytotoxic effects of oxygen. Results ...

1986-01-01

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Enhanced cadmium cytotoxicity in A549 cells with reduced glutathione levels is due to neither enhanced cadmium accumulation nor reduced metallothionein synthesis

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2011-03-01

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Biochemical and ultrastructural processing of ["1"2"5I]epidermal growth factor in rat epidermis and hair follicles: accumulation of nuclear label

Glutathione (GSH) depletion sensitizes human lung carcinoma (A549-T27) cells to the cytotoxic effects of Cd++. The effects of GSH depletion on Cd++ accumulation and Cd++-induced metallothionein (MT) content were investigated to determine the possible role of these Cd++ responses in the sensitization process. Cellular GSH was depleted to 20% to 25% of control levels with buthionine sulfoximine (BSO), or diethyl maleate (DEM), respectively. Neither treatment significantly affected Cd++-induced accumulation of exogenous 35s-cysteine into intracellular MT in a dose-dependent fashion. The results indicate that neither enhanced Cd++ accumulation nor reduced MT synthesis plays a primary role in affecting enhanced Cd++ cytotoxicity in A549 cells with reduced GSH levels. Although BSO inhibition of GSH synthesis enhanced MT synthesis, it sensitized the cells to Cd++, which suggests an additive ...

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Biochemical and ultrastructural processing of (/sup 125/I)epidermal growth factor in rat epidermis and hair follicles: accumulation of nuclear label

Although the intracellular ultrastructural processing of epidermal growth factor (EGF) and its receptor have been described in cell culture systems, very few studies have examined this phenomenon in intact tissues. We have examined the ultrastructural and biochemical handling of ["1"2"5I]EGF in the epidermis and hair follicle bulb of intact, viable, 3- to 5-day-old rat skin the EGF receptor distribution of which has already been documented and in which EGF has been shown to be biologically active. After incubation of explants with 10 nM ["1"2"5I]EGF for 2.5 h at 25 degrees or 37 degrees C, radiolabel was detected over the basal cells of the epidermis and hair follicle outer root sheath, confirming previous light microscope observations. More specifically, silver grains were observed near coated and uncoated plasma membrane and coated membrane invaginations, Golgi apparatus, lysosomal structures, and nuclei. Sodium azide inhibited ...

1987-01-01

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Evaluation of heavy-metal ion toxicity in fish cells using a combined stress protein and cytotoxicity assay

Although the intracellular ultrastructural processing of epidermal growth factor (EGF) and its receptor have been described in cell culture systems, very few studies have examined this phenomenon in intact tissues. We have examined the ultrastructural and biochemical handling of (/sup 125/I)EGF in the epidermis and hair follicle bulb of intact, viable, 3- to 5-day-old rat skin the EGF receptor distribution of which has already been documented and in which EGF has been shown to be biologically active. After incubation of explants with 10 nM (/sup 125/I)EGF for 2.5 h at 25 degrees or 37 degrees C, radiolabel was detected over the basal cells of the epidermis and hair follicle outer root sheath, confirming previous light microscope observations. More specifically, silver grains were observed near coated and uncoated plasma membrane and coated membrane invaginations, Golgi apparatus, lysosomal structures, and nuclei. Sodium azide inhibited ...

1987-03-01

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Cytotoxic effects of WR-2721 on mouse testicular cells

All organisms, from bacteria and yeast to humans, respond to physical and chemical stressors by increasing the synthesis of a small group of cellular stress proteins.'' The authors have developed a simple in vitro system for quickly screening environmentally relevant stressors to detect stress-induced proteins that are good candidates for biomarkers. Polyacrylamide gel electrophoresis was used to detect stressor-induced, concentration-dependent changes in cellular stress protein levels in two fish cell culture systems, whereas simultaneous in vitro neutral red uptake cytotoxicity assays measured the stressors effect on cellular physiology. There was a direct concentration-dependent relationship between sublethal cytotoxic effects and the increases in stress protein levels. Increases of 50 to 200% were detected in stress proteins from desert topminnow, Poeciliopsis lucida, ...

1994-08-01

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Genotoxicity of 2-alkylcyclobutanones, markers for an irradiation treatment in fat-containing food--Part I: cyto- and genotoxic potential of 2-tetradecylcyclobutanone

WR-2721 (S-2-(3-aminopropylamino)ethylphosphorothioic acid) has been demonstrated to be cytotoxic to stem spermatogonia in the mouse. Five and 10 injections of 300 mg/kg killed sufficient numbers of stem cells to reduce sperm production 56 days after treatment by 16 and 43%, respectively. Single injections of 300 or 400 mg/kg of WR-2721 given 15 min after irradiation produced negligible toxicity to stem cells as measured by counts of repopulated tubules; 600 mg/kg reduced stem cell survival by 47%. Four daily injections of 300 mg/kg given 4, 3, 2, and 1 days prior to irradiation reduced stem cell survival by about 60%. The cytotoxic effects of WR-2721 on testicular stem cells at least partially explains the reduced protection factors observed in the testis with low doses of radiation and during fractionated treatments involving multiple injections of drug.

1984-09-01

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Liposome encapsulation of lipophilic N-alkyl-propanediamine platinum complexes: impact on their cytotoxic activity and influence of the carbon chain length

Previous experiments had indicated a slight genotoxic potential both in rat and in human colon cells of a sample of 2-dodecylcyclobutanone, a compound formed by irradiation of food containing palmitic acid in its triglycerides. Up to date, there is no evidence that 2-alkylcyclobutanones occur in non-irradiated foodstuffs, consequently it is prudent to test several members of the class of 2-alkylcyclobutanones which are produced by treatment of fat-containing food with ionising radiation. In this work, 2-tetradecylcyclobutanone (derived from stearic acid) has been tested for its cytotoxic and genotoxic potential. Human colon tumor cell lines, i.e. HT 29 and HT 29 clone 19A, were employed as models for in vitro experiments for cytotoxicity and genotoxicity tests. Cytotoxicity was measured by tetrazolium salt reduction assays (MTT and WST-1) and genotoxicity by determining DNA damage using the Comet Assay. Neither ...

2002-03-01

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Preparation of biodegradable PLA/PLGA membranes with PGA mesh and their application for periodontal guided tissue regeneration

Antitumor platinum(II) complexes derived from N-alkyl-propanediamine differing in the length of their carbon chain (C8, C10, C12 and C14) were incorporated in liposomes and the cytotoxic activity of these formulations was evaluated against tumor (A{sub 549}, MDA-MB-231, B16-F1 and B16-F10) and non-tumor (BHK-21 and CHO) cell lines. Stable and monodisperse liposome suspensions incorporating the platinum complexes were obtained from the lipid composition consisting of distearoyl-sn-glycero-3-phosphocholine, cholesterol and 1,2-distearoyl-sn-glycero- 3-phosphoethanolamine-N-(methoxy(polyethylene glycol)-2000) at 5:3:0.3 molar ratio. The entrapment efficiency (EE%) of the platinum complexes in liposomes increased with the carbon chain length. EE% was higher than 80% in C12- and C14-derivatives. The effect of liposome encapsulation on the cytotoxic activity of the complexes was found to depend on the carbon chain length. These ...

2010-07-01

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Cancer-cell-specific cytotoxicity of non-oxidized iron elements in iron core-gold shell NPs

A biodegradable polylactic acid (PLA)/poly(glycolide-co-lactide) copolymer (PLGA) membrane with polyglycolic acid (PGA) mesh was prepared to aid the effective regeneration of defective periodontal tissues. The microporous membrane used in this study consists of biodegradable polymers, and seems to have a structure to provide appropriate properties for periodontal tissue regeneration. Based on the albumin permeation test, it is known that the biodegradable membrane exhibits the suitable permeability of nutrients. The membrane maintained its physical integrity for 6-8 weeks, which could be sufficient to retain space in the periodontal pocket. Cell attachment and cytotoxicity tests were performed with respect to the evaluation of biocompatibility of the membrane. As a result, the membrane did not show any cytotoxicity. The safety and therapeutic efficacies of the biodegradable membranes were confirmed in animal tests.

2009-10-01

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British Library Electronic Table of Contents (United Kingdom)

Gold-coated iron nanoparticles (NPs) selectively and significantly (P <0.0001) inhibit proliferation of oral- and colorectal-cancer cells in vitro at doses as low as 5 mg/mL, but have little adverse effect on normal healthy control cells. The particle treatment caused delay in cell-cycle progression, especially in the S-phase. There was no significant difference in the NP uptake between cancer and control cells, and cytotoxicity resulted primarily from the iron core, before oxidation, rather than from the Fe ions released from the core. In contrast with magnetic NPs that usually serve as drug carriers, diagnostic probes or hyperthermia media, the iron, before oxidation, in the NPs selectively suppressed cancer cell growth and left healthy control cells unaffected in vitro and in vivo. This...

2011-01-01

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Antitumor and Antiviral Activity of Colombian Medicinal Plant Extracts

Scientific Electronic Library Online (English)

Abstract in english Extracts of nine species of plants traditionally used in Colombia for the treatment of a variety of diseases were tested in vitro for their potential antitumor (cytotoxicity) and antiherpetic activity. MTT (Tetrazolium blue) and Neutral Red colorimetric assays were used to evaluate the reduction of viability of cell cultures in presence and absence of the extracts. MTT was also used to evaluate the effects of the extracts on the lytic activity of herpes simplex virus type (more) 2 (HSV-2). The 50% cytotoxic concentration (CC50) and the 50% inhibitory concentration of the viral effect (EC50) for each extract were calculated by linear regression analysis. Extracts from Annona muricata, A. cherimolia and Rollinia membranacea, known for their cytotoxicity were used as positive controls. Likewise, acyclovir and heparin were used as positive controls of antiherpetic ...

1999-07-01

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Biological Research for Radiation Protection

Induction of biotransformation in the liver of Eel (Anguilla anguilla L. ) by sublethal exposure to dinitro-o-cresol: An ultrastructural and biochemical study

The work scope of 'Biological Research for the Radiation Protection' had contained the research about ornithine decarboxylase and its controlling proteins, thioredoxin, peroxiredoxin, S-adenosymethionine decarboxylase, and glutamate decarboxylase 67KD effect on the cell death triggered ionizing radiation and H_2O_2(toxic agents). In this study, to elucidate the role of these proteins in the ionizing radiation (or H_2O_2)-induced apoptotic cell death, we utilized sensesed (or antisensed) cells, which overexpress (or down-regulate) RNAs associated with these proteins biosynthesis, and investigated the effects of these genes on the cytotoxicity caused by ionizing radiation and H_2O_2(or paraquat). We also investigated whether genisteine(or thiamine) may enhance the cytotoxic efficacy of tumor cells caused by ionizing radiation (may enhance the preventing effect radiation or ...

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Intracellular Calcium Concentration in the Glutamate-induced Cytotoxicity in PCl2 Cell

Structural and functional alterations in hepatocytes of the European eel, Anguilla anguilla, following a 4-week-exposure to 5, 50, and 250 micrograms/liter dinitro-o-cresol (DNOC) were investigated by means of electron microscopy and biochemistry and compared to liver pathology in eels exposed to the chemical spill into the Rhine river at Basle in November 1986. Whereas phenological parameters (growth, condition factor) are unaffected, ultrastructural and biochemical alterations are detectable at greater than or equal to 50 and 5 micrograms/liter DNOC, respectively. Structural modifications include: rounding-up of the nuclei; fractionation and reduction of the rough endoplasmic reticulum; proliferation of the smooth endoplasmic reticulum (SER), mitochondria, peroxisomes, and lysosomes; bundles of rod-shaped SER profiles; annulate lamellae; membrane whorls within mitochondria; crystallization of the peroxisomal matrix and glycogen bodies; glycogen depletion and ...

1991-04-01

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Surgical adjuvant therapy in colon carcinoma: a human tumor spheroid model for evaluating radiation sensitizing agents

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2002-12-01

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Stereospecific ligands and their complexes. Part VII. Synthesis, characterization and in vitro antitumoral activity of platinum(II) complexes with O,Oprime-dialkyl esters of (S,S)-ethylenediamine-N,Nprime-di-2-(4-methyl)pentanoic acid

HT-29 human colon tumor cells growing as spheroids have been evaluated as a model system for measuring the response of human colon tumor cell to antineoplastic agents. HT-29 cells have been capacity to form spheroids up to 1 mm or more in diameter when grown in spinner culture. The multicellular HT-29 spheroids develop hypoxic centers reflecting the cellular conditions found in human cancer treatment, i.e., nutritionally deficient hypoxic cells that are felt to be a significant source of both radiation and chemotherapy clinical treatment failures. Spheroids of increasing size were radiated and then dispersed into single cells for colony survival assay. Compared with irradiated single cell suspensions, the spheroid cells demonstrated a significant increase in radioresistance. Growing spheroids developed a complex radiation survival curve which was variable with respect to size of the spheroid. The drug 5-Fu was studied to examine in a preliminary fashion its interaction with these ...

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British Library Electronic Table of Contents (United Kingdom)

Platinum(II) complexes (1-4) with bidentate N,Nprime-ligands, O,Oprime-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,Nprime-di-2-(4-methyl)pentanoic acid were synthesized and characterized by IR, 1H NMR and 13C NMR spectroscopy and elemental analysis. DFT calculations were performed for the complexes and it was found that only one diastereoisomer could be formed. Cytotoxic activity of complexes 1-4 was determined against chronic lymphocytic leukemia cells (CLL) and compared to the activity of ligand precursors L12HCl-L42HCl and corresponding palladium(II) complexes, [PdCl2L] (L = L1-L4). The complexes were found to exhibit significantly higher antitumor activities than cisplatin on CLL cells. Cytotoxic effect of platinum(II) complexes on CLL cel...

2011-01-01

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Inhalation of tobacco smoke induces increased proliferation of urinary bladder epithelium and endothelium in female C57BL/6 mice

A?(1-42) Aggregates into non-Toxic Amyloid Assemblies in the Presence of the Natural Polyphenol Oleuropein Aglycon.

Cigarette smoking is the major environmental risk factor for bladder cancer in humans. Aromatic amines, potent DNA-reactive bladder carcinogens present in cigarette smoke, contribute significantly. However, increased cell proliferation, caused by direct mitogenesis or in response to cytotoxicity, may also play a role since urothelial hyperplasia has been observed in human cigarette smokers. We examined the urothelial effects of cigarette smoke (whole body inhalation exposure (Teague) system) in female C57BL/6 mice at various times in two studies, including reversibility evaluations. In both studies, no urothelial hyperplasia was observed by light microscopy in any group. However, in study 1, the Ki-67 labeling index (LI) of the urothelium was significantly increased in the smoke exposed group compared to controls through 3 months, but was not present at 6, 9 or 12 months even with continued exposures. In the groups that discontinued smoke ...

2007-11-20

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A surface acoustic wave electric field strength meter for environmental studies of HV transmission lines

Amyloid aggregation starts with the initial misfolding of peptide/protein precursors, with subsequent structural rearrangement into oligomers and protofibrils; the latter eventually organize into fibrils with shared basic structural features, found deposited in amyloid diseases. Mounting evidence indicates early oligomers as the most toxic amyloid species; accordingly, the search of inhibitors of their growth is considered a promising target to prevent amyloid toxicity. We recently showed that oleuropein aglycon, a polyphenol abundant in the extra virgin olive oil, interferes with the aggregation of amylin (involved in type-2 diabetes), eliminating its cytotoxicity. Here we report that oleuropein aglycon also hinders amyloid aggregation of A?(1-42) and its cytotoxicity, suggesting a general effect of such polyphenol. In particular, by using a wide panel of different spectroscopic, immunologic, cell viability and imaging ...

2011-05-18

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Differential immunotoxic effects of inorganic and organic mercury species in vitro

In recent years, there has been a significant increase in concern over the health and safety aspects of high voltage transmission lines (HVTL). The majority of research has focused on effects directly or indirectly involved with the central nervous system, including physiological, ultrastructural, and biochemical alterations, changes in blood composition, behaviour, reproduction, and development. Several recent epidemiological reports have presented preliminary data suggesting an increase in the incidence of cancer among children and adults exposed to magnetic fields through living close to various types of electrical power lines or devices. With the increase in environmental concerns there has been a concomitant consideration of biological effects and health implications related to presently existing HVTL and those planned in the future. It was concluded that the electric and magnetic field strengths and the electrical ...

1988-04-01

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British Library Electronic Table of Contents (United Kingdom)

Despite the fact that humans are exposed to multiple forms of mercury (elemental, inorganic, and organic), most research on mercury toxicity has focused on methylmercury (MeHg) and on neurotoxic outcomes and mechanisms. Recent work has indicated that the immunotoxic effects of mercury compounds may be significant contributors to human disease as well as mechanistically relevant to other target organ toxicities. In this study, we compared the effects of inorganic Hg (iHg) to organic Hg species (MeHg and ethylmercury, EtHg) in human peripheral blood mononuclear cells (PBMCs) in vitro at sub-cytotoxic concentrations, using methods developed to characterize response of human PBMCs to iHg in vitro. PBMCs were isolated from six volunteer blood donors (three males and three females) and cultured ...

2010-01-01

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Mutagenic and cytotoxic activity of doxorubicin and daunorubicin derivatives on prokaryotic and eukaryotic cells.

The expression profile of TLR9 mRNA and CpG ODNs immunostimulatory actions in the teleost gilthead seabream points to a major role of lymphocytes

The mutagenic and cytotoxic activity of two newly synthesized doxorubicin derivatives and of one daunorubicin derivative were studied in V79 Chinese hamster cells and bacteria (Salmonella typhimurium...Full Text Available

1984-07-01

34

British Library Electronic Table of Contents (United Kingdom)

Abstract. The potential effects of synthetic unmethylated oligodeoxynucleotides (ODN) containing CpG motifs, mimicking bacterial DNA, has never been evaluated on the immune response in the teleost fish gilthead seabream (Sparus aurata), the most important fish species in Mediterranean aquaculture. First, binding and competition studies have demonstrated that binding is saturated and promiscuous, suggesting the participation of several receptors. Moreover, leucocyte cytotoxic (NCC) activity, production of ROIs (reactive oxygen intermediates), and expression of immune-relevant genes was greatly primed by ODNs. Focusing on the mechanism, the TLR9 gene is widely distributed in seabream tissues and differently regulated in vitro by several stimuli. Moreover, and for the first time in fish, TLR9...

2008-01-01

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Report on NCI symposium: comparison of mechanisms of carcinogenesis by radiation and chemical agents. II. Cellular and animal models

Inflammatory Biomarkers of Sulfur Mustard Analog 2-Chloroethyl Ethyl Sulfide-Induced Skin Injury in SKH-1 Hairless Mice

The point at which the common final pathway for induction of cancer by chemical carcinogens and ionizing radiation has not been identified. Although common molecular targets are suggested by recent findings about the role of oncogenes, the mechanism by which the deposition of radiation energy and the formation of adducts or other DNA lesions induced by chemicals affects the changes in the relevant targets may be quite different. The damage to DNA that plays no part in the transformation events, but that influences the stability of the genome, and therefore, the probability of subsequent changes that influence tumorigenesis may be more readily induced by some agents than others. Similarly, the degree of cytotoxic effects that disrupt tissue integrity and increase the probability of expression of initiated cells may be dependent on the type of carcinogen. Also, evidence was presented that repair of the initial lesions could be demonstrated after ...

1984-05-20

36

British Library Electronic Table of Contents (United Kingdom)

Sulfur mustard (HD) is an alkylating and cytotoxic chemical warfare agent, which inflicts severe skin toxicity and an inflammatory response. Effective medical countermeasures against HD-caused skin toxicity are lacking due to limited knowledge of related mechanisms, which is mainly attributed to the requirement of more applicable and efficient animal skin toxicity models. Using a less toxic analog of HD, chloroethyl ethyl sulfide (CEES), we identified quantifiable inflammatory biomarkers of CEES-induced skin injury in dose- (0.05-2 mg) and time- (3-168 h) response experiments, and developed a CEES-induced skin toxicity SKH-1 hairless mouse model. Topical CEES treatment at high doses caused a significant dose-dependent increase in skin bi-fold thickness indicating edema. Histopathological e...

2009-01-01

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A variable gene delivery carrier-biotinylated chitosan/polyethyleneimine

Ultrastructural Evidence of Dermal Gadolinium Deposits in a Patient with Nephrogenic Systemic Fibrosis and End-Stage Renal Disease

A variable gene delivery system has been developed based on conjugating chitosan to biotin through a functionalized poly(ethylene glycol) (PEG) spacer, which can be used to further bind different molecules on the outer layer of a polymer/DNA complex by streptavidin (SA)-biotin linkage. In this study, TAT-conjugated SA was used as the model molecule to prove the conjugation function of the prepared complex. In addition, low-molecular-weight poly(ethyleneimine) (PEI) was added into the polymer/DNA complex to increase the transfection efficiency. The results of the luciferase assay show that the transfection efficiency of the prepared complex was significantly correlated with the amount of PEI and was further enhanced when TAT was conjugated to the complex by SA-biotin linkage. Considered to have negligible cytotoxic effects, the variable gene delivery complex prepared in this study would be of considerable potential as carriers for in vitro ...

2010-12-01

38

Nitrogen nutrient status induces sexual differences in responses to cadmium in Populus yunnanensis

Background and objectives: The pathogenesis of acquired nephrogenic systemic fibrosis recently described for patients with renal insufficiency and a history of exposition to gadolinium-based magnetic...Full Text Available

2008-07-01

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Morphology and Ultrastructure of Maternal Seed Tissues of Soybean in Relation to the Import of Photosynthate

Populus yunnanensis was employed as a model species to detect sexual differences in growth, physiological, biochemical, and ultrastructural responses to cadmium (Cd) stress, nitrogen...Full Text Available

2011-10-01

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Impact of physical training on the ultrastructure of midthigh muscle in normal subjects and in patients treated with glucocorticoids.

Cytological observations were made on developing seeds of soybean (Glycine max (L.) Merr. “Amsoy 71”) using scanning and transmission electron microscopy and light microscopy....Full Text Available

1981-05-01

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Cytochemical localisation and characterisation of proteoglycans (glycosaminoglycans) in the epithelial-stromal interface of the seminal vesicle of the guinea pig.

Exercise-training might be a logical method to reverse muscle atrophy and weakness in patients treated with glucocorticoids. The purpose of the present investigation was to establish whether a treatment...Full Text Available

1987-04-01

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Cogan's microcystic dystrophy of the cornea: ultrastructure and photomicroscopy.

The proteoglycans (PGs) in the guinea pig seminal vesicle were demonstrated ultrastructurally by both cuprolinic blue (CB) and ruthenium red (RR) staining. The PGs appeared as electron-dense granules...Full Text Available

1992-02-01

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The skin of Osedax (Siboglinidae, Annelida): An ultrastructural investigation of its epidermis

Corneal biopsy specimens from 3 patients with Cogan's microcystic corneal dystrophy were examined by light and electron microscopy. Specimens were taken from corneas showing microcysts, geographic or...Full Text Available

1978-12-01

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British Library Electronic Table of Contents (United Kingdom)

The symbiotic polychaetes of the genus Osedax living on the bones of whale carcasses have become known as bone-eating worms. It is believed that whale bones are the source of nutrition for those gutless worms and that fatty acids are produced by their symbionts and transferred to the host. However, the symbionts are of the heterotrophic group Oceanospirillales and as such are not able to synthesize organic carbon de novo. Also, they are not housed in close contact to the bone material. We studied the ultrastructure of the integument overlying the symbiont housing trophosome in the ovisac region and the roots region and of the symbiont-free trunk region of Osedax to investigate the hosts possible contribution in feeding for the whole symbiosis. The epidermis differs conspicuously between th...

2010-01-01

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Physiological responses of Pinus sylvestris to changing carbon dioxide and ozone concentrations

Effective use of optimized, high-dose (50 kGy) gamma irradiation for pathogen inactivation of human bone allografts.

The objective of this research is to study the effects of elevated ozone, carbon dioxide and their combination on ultrastructural, physiological and biochemical responses of Scots pine needles and how these effects are reflected to photosynthesis, carbohydrate and nutrient allocation and finally to shoot and root growth of trees. In addition the interactions of the studied trees and mycorrhizal fungi as well as insect herbivores are studied. The exposures have been running only for two growing periods and it seems necessary to continue the experiment over the third growing season in 1996. Since the analyses are partially incomplete, only preliminary conclusions are possible at the moment. The slightly increased shoot growth and needle width and increased amount of starch in chloroplasts point to the slight stimulating effect of elevated CO{sub 2} among the chamber treatments. Altogether the growth of ...

1996-12-31

46

Novel Cytotoxic Vectors Based on Adeno-Associated Virus

The safety of tissue allografts has come under increased scrutiny due to recent reports of allograft-associated bacterial and viral infections in tissue recipients. We report that 50 kGy of gamma irradiation, nearly three times the dose currently used, is an effective pathogen inactivation method when used under optimized conditions that minimize damage to the tissue. Cancellous bone dowels treated with a radioprotectant solution and 50 kGy of optimized irradiation had an ultimate compressive strength and modulus of elasticity equal to conventionally irradiated (18 kGy) and non-irradiated control bone grafts. We subjected bone dowels treated with this pathogen inactivation method to an in vitro cytotoxicity test using three different mammalian cell lines and concluded that the treated grafts were not cytotoxic. The log reduction of nine pathogens spiked into radioprotectant-treated bone irradiated to 50 kGy was also tested. ...

2005-05-01

47

Alpha-toxin of Staphylococcus aureus.

positive primary PymT breast cancer cells in primary co-cultured tumor tissue, suggesting target specificity of

48

Rapid toxicity testing based on mitochondrial respiratory activity

Alpha-toxin, the major cytotoxic agent elaborated by Staphylococcus aureus, was the first bacterial exotoxin to be identified as a pore former. The protein is secreted as a single-chain, water-soluble...Full Text Available

1991-12-01

49

Programmed cell death during pigment gland formation in Gossypium hirsutum leaves

The need exists for rapid and inexpensive methods to determine the health effects of environmental contaminants on biological systems. One of the current research approaches for assessing cytotoxicity is to monitor the respiratory activity of the mitochondrion, a sensitive, nonspecific subcellular target site. Detected changes in mitochondrial function after the addition of a test chemical could be correlated to toxic effects. Mitochondrial respiration can be characterized by three indices: state 3 and state 4 respiratory rates, and the respiratory control ratio (RCR). State 4, the idle or resting state, results when coupled mitochondrial respire in a medium containing inorganic phosphate and a Kreb's cycle substrate in the absence of a phosphate acceptor such as adenosine diphosphate (ADP). In the presence of ADP the respiration rate increases to a maximum (state 3), accompanied by phosphorylation of ADP to ...

1990-05-01

50

British Library Electronic Table of Contents (United Kingdom)

Abstract Ultrastructural studies have shown that the formation of pigment glands in Gossypium hirsutum L. leaves is a lysigenous process, originating from a cluster of cells in the ground meristem. Various techniques were used here to investigate whether programmed cell death (PCD) plays a critical role in this developmental process. Nuclei of internal cells in the pigment gland-forming tissue were TUNEL-positive and DAPI-negative, suggesting that DNA cleavage is an early event and complete DNA degradation is a late event. Smeared bands and a lack of laddering after gel electrophoresis indicate that DNA cleavage is random. Ultrastructurally, secretory cells in the pigment glands become distorted, nuclei are densely stained, and chromosomes become condensed until completely degraded at late...

2010-01-01

51

Photochemically and Pharmacological studies of Maytenus Frosskaoliana

In vitro corrosion, cytotoxicity and hemocompatibility of bulk nanocrystalline pure iron

Column chromatography of the petroleum ether and chloroformic extracts of Maytenus Forsskaoliana afforded four compounds: friedilin1, B-amyrin 2, B-sitosterol 3 and betulin 4. The structure of these compounds were established on bases of spectral (IR,MS,H and C-NMR)as well as physical data. Antimicrobial activity for extracts indicated weak potency (200ug/ml) while betulin4 showed a pronounced activity (MIC and MBC 20ug/ml).The cytotoxic activity of beutalin4 significantly indicated promising activity (IC50 40ug/ml) on both HeLa and Hep-2 cells. The pharmacological activity of diferent extracts showed sedative effect, slowing respiration, dose -dependent decrease in the arterial blood pressure by 40.1mm Hg (at adose 200mg /kg),decrease in the heart rate 67.3% (at a dose 50mg /kg)and decrease in the body temperature by 4.2C after 2 hrs (at a dose 200mg /kg). (author)

52

Evaluating the cytotoxicity of palladium/magnetite nano-catalysts intended for wastewater treatment

Bulk nanocrystalline pure iron rods were fabricated by the equal channel angular pressure (ECAP) technique up to eight passes. The microstructure and grain size distribution, natural immersion and electrochemical corrosion in simulated body fluid, cellular responses and hemocompatibility were investigated in this study. The results indicate that nanocrystalline pure iron after severe plastic deformation (SPD) would sustain durable span duration and exhibit much stronger corrosion resistance than that of the microcrystalline pure iron. The interaction of different cell lines reveals that the nanocrystalline pure iron stimulates better proliferation of fibroblast cells and preferable promotion of endothelialization, while inhibits effectively the viability of vascular smooth muscle cells (VSMCs). The burst of red cells and adhesion of the platelets were also substantially suppressed on contact with the nanocrystalline pure iron in blood circulation. A clear ...

2010-12-01

53

A new method for quantifiable and controlled dosage of particulate matter for in vitro studies: the electrostatic particulate dosage and exposure system (EPDExS).

Palladium/magnetite nanoparticulate catalysts were developed for efficient elimination of halogenated organic pollutants from contaminated wastewater. Particle recovery from treated water can be ensured via magnetic separation. However, in worst-case scenarios, this catalyst removal step might fail, leading to particle release into the environment. Therefore, a toxicological study was conducted to investigate the impact of both pure magnetite and palladium/magnetite nanoparticle exposure upon human skin (HaCaT) and human colon (CaCo-2) cell lines and a cell line from rainbow trout gills (RTgill-W1). To quantify cell viability after particle exposure, three endpoints were examined for all tested cell lines. Additionally, the formation of reactive oxygen species was studied for the human cells. The results showed only minor effects of the particles on the tested cell systems and support the assumption that palladium/magnetite nano-catalysts can be implemented for a ...

2010-01-01

54

Coir fibre toxicity: in vivo and in vitro studies.

An exposure chamber is described for the quantifiable addition of fine and ultrafine aerosol particulate matter directly to cells and used to demonstrate the in vitro cytotoxicity of fine 1,4-naphthoquinone particles to murine lung epithelial cells. The electrostatic particulate dosage and exposure system (EPDExS) operates on the principle of electrostatic precipitation and is shown to deposit fine and ultrafine aerosol particles directly to cells with 100% efficiency for particle diameters in the range of 40-530nm. This range is not limited by the EPDExS, but rather by the aerosolization method used for this study. Numbers of particles deposited onto the cells are counted with a condensation particle counter, negating any need to calculate or estimate particle exposure. The process of particle introduction, assessed using Trypan blue dye exclusion, had no effect on cell viability. In combination with a differential mobility classifier, the ...

2008-06-08

55

Photobiological activity of marmesin (5-B-hydroxyisopropyl-4-5 dihydrofurocoumarin) in Chinese hamster V79 cells

The biological activity of coir fibre, coir ash and their components were investigated in vitro by measuring the haemolytic activity and macrophage cytotoxicity. In vivo studies carried out by injecting guinea pigs intratracheally with coir fibres resulted in resolving granulomas. The observed haemolytic activity and macrophage cytotoxicity was more marked with coir ash compared with coir fibres. Chemical analysis of coir ash revealed the presence of toxic chemical constituents in appreciable amounts. PMID:6283694

1982-03-01

56

Needle aspiration biopsy in the diagnosis of lytic bone lesions in histiocytosis X, Ewing's sarcoma and neuroblastoma

Marmesin was isolated from the medicinal plant, Afraegle paniculata. Its cytotoxicity and mutagenicity in Chinese hamster V79 cells when sensitized to near ultraviolet (NUV) and long wavelength ultraviolet light or black light (BL) were assayed. Marmesin was extremely cytotoxic in the dark. This cytotoxicity was photoenhanced in NUV and BL; the photoenhanced lethality being higher in NUV than in BL. The LD/sub 50/ of marmesin under NUV and BL photosensitization were 0.002 ..mu..M and (0.012 ..mu..M), respectively. In the absence of NUV and BL, marmesin's LD/sub 50/ was 0.013 ..mu..M.NUV and BL without marmesin were not significantly cytotoxic at the fluence rates of 0.29 W/m/sup 2/ and 4.2 W/m/sup 2/, respectively, for up to 20 min. In contrast to the observed high cytotoxicity of marmesin, its mutagenicity at the HGPRT locus (Asub(z)Gsup(r)) was weak. The implication of ...

1983-10-01

57

Morphological, Histochemical, Immunohistochemical, and Ultrastructural Characterization of Tumors and Dysplastic and Non-Neoplastic Lesions Arising in BK Virus/tat Transgenic Mice

Cytologic smears obtained by needle aspiration biopsy of lytic bone lesions in 15 patients with histiocytosis X, Ewing's sarcoma and neuroblastoma were reviewed. After conventional staining, histiocytosis X could be diagnosed and differentiated from small cell tumours such as Ewing's sarcoma and neuroblastoma. The need for sampling material for cytochemical and ultrastructural analysis of these small cell tumours by needle aspiration is emphasized. (Auth.).

58

Nonphotochemical Hole-Burning Imaging Studies of in vitro Carcinoma and Normal Cells Utilizing a Mitochondrial Specific Dye

To study the role in AIDS pathogenesis of the human immunodeficiency virus type 1 (HIV-1) Tat protein, a transactivator of viral and cellular genes, we generated transgenic mice with a recombinant DNA...Full Text Available

1999-04-01

59

Nonphotochemical Hole-Burning Imaging Studies of In Vitro Carcinoma and Normal Cells Utilizing a Mitochondrial Specific Dye

Low temperature Nonphotochemical Hole Burning (NPHB) Spectroscopy of the dye rhodamine 800 (MF680) was applied for the purpose of discerning differences between cultured normal and carcinoma ovarian surface epithelial (OSE) cells. Both the cell lines were developed and characterized at the Mayo Clinic (Rochester, MN), with the normal cell line having been transfected with a strain of temperature sensitive Simian Virus 40 Large T Antigen (SV40) for the purpose of extending the life of the cell culture without inducing permanent changes in the characteristics of the cell line. The cationic lipophilic fluorophore rhodamine 800 preferentially locates in in situ mitochondria due to the high lipid composition of mitochondria and the generation of a large negative membrane potential (relative to the cellular cytoplasm) for oxidative phosphorylation. Results presented for NPHB of MF680 located in the cells show significant differences between the two cell lines. The results are interpreted on ...

2002-06-27

60

Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice

Low temperature Nonphotochemical Hole Burning (NPHB) Spectroscopy of the dye rhodamine 800 (MF680) was applied for the purpose of discerning differences between cultured normal and carcinoma ovarian surface epithelial (OSE) cells. Both the cell lines were developed and characterized at the Mayo Clinic (Rochester, MN), with the normal cell line having been transfected with a strain of temperature sensitive Simian Virus 40 Large T Antigen (SV40) for the purpose of extending the life of the cell culture without inducing permanent changes in the characteristics of the cell line. The cationic lipophilic fluorophore rhodamine 800 preferentially locates in in situ mitochondria due to the high lipid composition of mitochondria and the generation of a large negative membrane potential (relative to the cellular cytoplasm) for oxidative phosphorylation. Results presented for NPHB of MF680 located in the cells show significant differences between the two cell lines. The results are interpreted on ...

2002-08-01

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61

Relationship of DNA repair processes to mutagenesis and carcinogenesis in mammalian cells. Progress report, November 1, 1979-October 31, 1980

Olfactory tract has been demonstrated to be an important portal for inhaled solid nanoparticle transportation into the central nervous system (CNS). We have previously demonstrated that intranasally instilled Fe_2O_3 nanoparticles could transport into the CNS via olfactory pathway. In this study, we investigated the neurotoxicity and size effect of repeatedly low-dose (130 #mu#g) intranasal exposure of nano- and submicron-sized Fe_2O_3 particles (21 nm and 280 nm) to mice. The biomarkers of oxidative stress, activity of nitric oxide synthases and release of monoamine neurotransmitter in the brain were studied. Our results showed that significant oxidative stress was induced by the two sizes of Fe_2O_3 particles. The activities of GSH-Px, Cu,Zn-SOD, and cNOS significantly elevated and the total GSH and GSH/GSSG ratio significantly decreased in the olfactory bulb and hippocampus after the nano- and submicron-sized Fe_2O_3 particle treatment (p < 0.05). The ...

2009-01-01

62

Regulatory compliance | Mott MacDonald

The objective of this research is to determine the role of DNA repair in mutagenesis and carcinogenesis in mammalian cells. Use of the host-cell reactivation viral suicide enrichment procedure was initiated in the isolation of repair-deficient mutants. Lightly mutagenized BHK cells were infected with irradiated Herpes simplex virus (HSV); several radiation-sensitive strains were isolated among the survivors of the infection. The characterization of these strains is progressing and the enrichments are continuing. That alterations in the frequency of mutation of C3H/10T 1/2 cells, occurring as a result of holding the cells in a confluent state following treatment with ethylmethane sulfonate, parallel the alterations in the frequency of neoplastic transformation was found. The repair capabilities of BHK cells were found to be intermediate in comparison to repair-proficient and -deficient human cells with regard to the reactivation of HSV treated with various inactivating agents. The ...

63

Osteoblast response to dimethacrylate composites varying in composition, conversion and roughness using a combinatorial approach

...broad range of experience in designing and building research and development laboratories for products such as vaccines, blood and sera, biological products, medical devices, solid dosage forms , highly potent products and cytotoxic material. We also have experience in a range of modular laboratories for TSE research, ...

64

Novel platinum(II) complexes of long chain aliphatic diamine ligands with oxalato as the leaving group: Comparative cytotoxic activity relative to chloride precursors

Dimethacrylate polymers and composites are seeing increased usage in orthopedics. As these applications require the material to integrate with the surrounding tissues, direct contact cytotoxicity...Full Text Available

2009-09-01

65

Non-cytotoxic, In Situ Gelable Hydrogels Composed of N-carboxyethyl Chitosan and Oxidized Dextran

Platinum complexes play an important role in the development of anticancer drugs. Their cytotoxicity can be influenced by the nature of the leaving ligands, due to the hydrolysis reaction that occurs prior to the binding of the platinum complex to DNA. Also, non-leaving groups such as lipophilic diamines may affect cellular uptake. In this work, we describe the synthesis of platinum(II) complexes having oxalato and long chain aliphatic N-alkyl ethylenediamines as ligands. The products were characterized by elemental analyses, infrared spectroscopy and {sup 1}H, {sup 13}C and {sup 195}Pt NMR spectroscopy. Biological activity was assessed against tumor cell lines (A{sub 549}, B16-F1, B16-F10, MDA-MB-231) and non-tumor cell lines (BHK-21 and CHO). The length of the carbon chain affects the cytotoxicity and the oxalato complexes were less cytotoxic than the respective chloride-containing analogues. (author)

2010-07-01

66

Mechanism of cell death resulting from DNA interstrand cross-linking in mammalian cells

A series of in situ gelable hydrogels were prepared from oxidized dextran (Odex) and N-carboxyethyl chitosan (CEC) without any extraneous crosslinking agent. The gelation readily...Full Text Available

2008-10-01

67

Malignant Catarrhal Fever of Cattle Is Associated with Low Abundance of IL-2 Transcript and a Predominantly Latent Profile of Ovine Herpesvirus 2 Gene Expression

DNA interstrand cross-links (ICLs) are critical cytotoxic lesions produced by cancer chemotherapeutic agents such as the nitrogen mustards and platinum drugs; however, the exact mechanism of ICL-induced...Full Text Available

2011-08-01

68

Identification of Genes Affecting the Toxicity of Anti-Cancer Drug Bortezomib by Genome-Wide Screening in S. pombe

BackgroundMalignant catarrhal fever (MCF) is a lethal disease of cattle, characterized by vasculitis, necrosis, and accumulation of activated, dysregulated cytotoxic lymphocytes...Full Text Available

69

Development and cytotoxicity evaluation of SiAlONs ceramics

Bortezomib/PS-341/Velcade, a proteasome inhibitor, is widely used to treat multiple myeloma. While several mechanisms of the cytotoxicity of the drug were proposed, the actual mechanism remains elusive....Full Text Available

70

Dengue virus protein recognition by virus-specific murine CD8+ cytotoxic T lymphocytes.

SiAlONs are ceramics with high potential as biomaterials due to their chemical stability, associated with suitable mechanical properties, such as high fracture toughness and fracture resistance. The objective of this work was to investigate the mechanical properties and the cytotoxicity of these ceramic materials. Three different compositions were prepared, using silicon nitride, aluminum nitride and a rare earth oxide mixture as starting powders, yielding Si_3N_4-SiAlON composites or pure SiAlON ceramics, after hot-pressing at 1750 deg. C, for 30 min. The sintered samples were characterized by X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). Furthermore, hardness and fracture toughness were determined using the Vicker's indentation method. The biological compatibility was evaluated by in vitro cytotoxicity tests. Ceramic with elevated hardness, ranging between 17 and 21 GPa, and high fracture toughness of 5 to 6 MPa ...

2007-01-01

71

Cytotoxicity of Atriplex confertifolia

The identification of the protein targets for dengue virus-specific T lymphocytes may be useful for planning the development of subunit vaccines against dengue. We studied the recognition by murine...Full Text Available

1993-02-01

72

Cytoprotective Activity of Glycyrrhizae radix Extract Against Arsenite-induced Cytotoxicity

The search for cancer treatment continues to be a global effort. As part of this global effort, many natural products have been tested against cancer cell lines, mostly from tropically located plants....Full Text Available

2010-01-01

73

Comparison of a Commercial Multiplex Real-Time PCR to the Cell Cytotoxicity Neutralization Assay for Diagnosis of Clostridium difficile Infections?

Licorice, Glycyrrhizae radix, is one of the herbal medicines in East Asia that has been commonly used for treating various diseases, including stomach disorders. This study investigated...Full Text Available

2008-06-01

74

Cerebellar cell surface antigens of mouse brain.

A commercial multiplex real-time PCR assay (Cepheid Xpert C. difficile assay) for the diagnosis of Clostridium difficile infection was evaluated. The sensitivity and...Full Text Available

2009-11-01

75

Capacity of deoxycytidine to selectively antagonize cytotoxicity of 5-halogenated analogs of deoxycytidine without loss of antiherpetic activity.

Reaggregated cells from 6- to 8-day-old mouse cerebella have been used to raise antibodies in rabbits. The interaction of these antibodies with cerebellar cell surface components was assessed by cytotoxicity...Full Text Available

1975-10-01

76

Ab binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism

Enzyme kinetic studies from this laboratory (M. Dobersen and S. Greer, Biochemistry 17:920-928, 1978) suggested that deoxycytidine could antagonize the toxicity of 5-halogenated analogs of deoxycytidine...Full Text Available

1982-09-01

77

A Substructure Combination Strategy to Create Potent and Selective Transthyretin Kinetic Stabilizers that Prevent Amyloidogenesis and Cytotoxicity

Abs facilitate humoral immunity via the classical mechanisms of opsonization, complement activation, Ab-dependent cellular cytotoxicity, and toxin/viral neutralization. There is also evidence that some...Full Text Available

2010-04-01

78

A Humanin Derivative Reduces Amyloid Beta Accumulation and Ameliorates Memory Deficit in Triple Transgenic Mice

Transthyretin aggregation-associated proteotoxicity appears to cause several human amyloid diseases. Rate-limiting tetramer dissociation and monomer misfolding of transthyretin (TTR) occur before...Full Text Available

2010-02-03

79

Diffusion-weighted MRI suggests the coexistence of cytotoxic and vasogenic oedema in a case of deep cerebral venous thrombosis

Humanin (HN), a 24-residue peptide, was identified as a novel neuroprotective factor and shows anti-cell death activity against a wide spectrum of Alzheimer's disease (AD)-related cytotoxicities, including...Full Text Available

80

In vitro toxicity of silica nanoparticles in human lung cancer cells

We report a 20-year-old woman who suffered headaches before presenting with a state of fluctuating vigilance. MRI showed diffuse high signal in the basal ganglia bilaterally on diffusion- and T2-weighted images, which had areas of both low and high apparent diffusion coefficient, presumed to correspond to cytotoxic and vasogenic oedema. MR venography showed no flow in the deep cerebral veins or straight sinus. Heparin was given, with clinical recovery. On follow-up MRI, the appearances became normal. (orig.)

2000-10-01

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81

Morphological and ultrastructural analysis of Turritopsis nutricula during life cycle reversal.

The cytotoxicity of 15-nm and 46-nm silica nanoparticles was investigated by using crystalline silica (Min-U-Sil 5) as a positive control in cultured human bronchoalveolar carcinoma-derived cells. Exposure to 15-nm or 46-nm SiO_2 nanoparticles for 48 h at dosage levels between 10 and 100 #mu#g/ml decreased cell viability in a dose-dependent manner. Both SiO_2 nanoparticles were more cytotoxic than Min-U-Sil 5; however, the cytotoxicities of 15-nm and 46-nm silica nanoparticles were not significantly different. The 15-nm SiO_2 nanoparticles were used to determine time-dependent cytotoxicity and oxidative stress responses. Cell viability decreased significantly as a function of both nanoparticle dosage (10-100 #mu#g/ml) and exposure time (24 h, 48 h, and 72 h). Indicators of oxidative stress and cytotoxicity, including total reactive oxygen species (ROS), glutathione, malondialdehyde, ...

2006-12-15

82

Tests for the diagnosis of Clostridium difficile infection: the next generation.

The hydrozoa life cycle is characterized, in normal conditions, by the alternation of a post-larval benthic polyp and an adult pelagic medusa; however, some species of Hydrozoa react to environmental stress by reverting their life cycle: i.e. an adult medusa goes back to the juvenile stage of polyp. This very uncommon life cycle could be considered as some sort of inverted metamorphosis. A morphological study of different stages during the reverted life cycle of Turritopsis nutricula led to the characterization of four different stages: healthy medusa, unhealthy medusa, four-leaf clover and cyst. The ultrastructural study of the cellular modifications (during the life cycle reversion of T. nutricula) showed the presence of both degenerative and apoptotic processes. Degeneration was prevalent during the unhealthy medusa and four-leaf clover stages, while the apoptotic rate was higher during the healthy medusa and cyst stages. The significant presence of degenerative ...

2003-06-01

83

Pituitary gland height evaluated by MR in patients with {beta}-thalassemia major: a marker of pituitary gland function

Clostridium difficile (C. difficile) causes 25-30% of cases of antibiotic associated diarrhea and most cases of pseudomembranous colitis. Patients presenting with diarrhea after hospitalization for 3 or more days should be tested for C. difficile. There are many options available for testing, each of which has inherent advantages and disadvantages. Most laboratories perform toxin testing using an enzyme immunoassay method. In general these tests have sensitivities ranging from 60 to 70% and specificities of 98%. When using these methods, symptomatic patients with negative tests should be tested by another more sensitive method. Until recently, cell culture cytotoxicity neutralization assays (CCNAs) were considered the gold standard in the U.S. A two-step algorithm using an EIA for glutamate dehydrogenase detection followed by testing positives using CCNA, offered an improved alternative until the availability of molecular assays. Although early studies that ...

2011-03-03

84

Optimizing the Protocol for Pulmonary Cryoablation: A Comparison of a Dual- and Triple-Freeze Protocol

In transfusion-dependent {beta}-thalassemia major, increased iron deposition in the pituitary gland has a cytotoxic effect leading mainly to hypogonadotropic hypogonadism. Our purpose was to assess in these patients the height of the pituitary gland and to evaluate whether it represents a marker of pituitary gland function. In 29 patients with {beta}-thalassemia major and 35 age- and gender-matched controls the pituitary gland height was evaluated in a midline sagittal scan using a spin echo T1-weighted (500/20 TR/TE) sequence. In all patients, an extensive endocrine evaluation was performed, including measurements of spontaneous and stimulated levels of gonadotropins, thyroid hormones, growth hormone, insulin-like growth factor, and adrenal hormones. The pituitary gland height was lower in thalassemic patients with hypogonadotropic hypogonadism (n=15) (mean 3.48; SD 0.46) than in the age- and gender-matched controls (mean 6.29; SD 0.77), ...

2001-12-01

85

Inhibitor of DNA synthesis is present in normal chicken serum

The purpose of this study was to compare a double freeze-thaw protocol to a triple freeze-thaw protocol for pulmonary cryoablation utilizing an in vivo porcine lung model. A total of 18 cryoablations were performed in normal porcine lung utilizing percutaneous technique with 9 each in a double- (10-5-10) and triple-freeze (3-3-7-7-5) protocol. Serial noncontrast CT images were obtained during the ablation. CT imaging findings and pathology were reviewed. No imaging changes were identified during the initial freeze cycle with either protocol. However, during the first thaw cycle, a region of ground glass opacity developed around the probe with both protocols. Because the initial freeze was shorter with the triple freeze-thaw protocol, the imaging findings were apparent sooner with this protocol (6 vs. 13 min). Also, despite a shorter total freeze time (15 vs. 20 min), the ablation zone identified with the triple freeze-thaw protocol was not significantly different from the double ...

2010-12-01

86

Does tea tree oil have a place in the topical treatment of burns?

The authors have found that heat-inactivated serum (57/sup 0/C for 1 hour) from normal chickens reduces the proliferation of mitogen-stimulated chicken and murine splenocytes as well as some transformed mammalian lymphoblastoid cell lines. Greater than a 50% reduction in /sup 3/H-thymidine incorporation was observed when concanavalin A (Con A)-activated chicken splenocytes that were cultured in the presence of 10% autologous or heterologous serum were compared to mitogen-stimulated cells cultured in the absence of serum. Normal chicken serum (10%) also caused greater than 95% suppression of /sup 3/H-thymidine incorporation by bovine (EBL-1 and BL-3) and gibbon ape (MLA 144) transformed lymphoblastoid cell lines. The only cell line tested that was not inhibited by chicken serum was an IL-2-dependent, murine cell line. Chicken serum also inhibited both /sup 3/H-thymidine incorporation and IL-2 synthesis by Con A-activated murine splenocytes. Suppression was caused by actions other than ...

1986-03-05

87

Cytotoxic evaluation of N-isopropylacrylamide monomers and temperature-sensitive poly(N-isopropylacrylamide) nanoparticles

Burnaid is a sorbalene-based cream containing 40 mg/g of tea tree oil and 1 mg/g of triclosan. This investigation was carried out to determine the effect of Burnaid, a commercial tea tree oil preparation, against Enterococcus faecalis (ATCC29212), Staphylococcus aureus (ATCC29213), Escherichia coli (ATCC25922), and Pseudomonas aeruginosa (ATCC27853), with the activity of the base product in the commercial preparation. The organisms were suspended in sterile saline (0.5 McFarland Standard) and inoculated onto horse blood agar (E. faecalis and S. aureus) or Mueller-Hinton agar (E. coli and P. aeruginosa). One hundred microliters of Burnaid unsterilized, Burnaid sterilized and the base product (Tinasolve) were placed in duplicate in wells cut into the agar plates. Sterility and inactivation cultures were also performed on the samples. None of the samples were found to be contaminated with bacteria prior to testing. Only S. aureus and E. coli showed zones of growth ...

1997-06-01

88

Cytotoxic Naphtho--pyrones from the Mangrove Endophytic Fungus Aspergillus tubingensis (GX1-5E)

The objective of this research project is to investigate the biocompatibility of N-isopropylacrylamide (NIPAAm) monomers and poly(N-isopropylacrylamide) (PNIPAAm) nanoparticles in vitro. PNIPAAm nanoparticles of different sizes were synthesized and characterized by transmission electron microscopy and dynamic light scattering. Cytotoxicity studies using MTS assays were conducted on fibroblasts, smooth muscle cells, and endothelial cells. In addition, the concentration of NIPAAm monomers remaining on PNIPAAm nanoparticles was determined using bromination and spectrophotometry. The cytotoxicity results did not show a significant difference in cell survival when cells were exposed to different particle sizes (100, 300, and 500 nm). Dose studies showed that all three cell types exposed to 100 nm PNIPAAm nanoparticles at concentrations less than or equal to 5 mg/mL were compatible, while cells exposed to NIPAAm monomers exhibited toxicity even at ...

2009-08-15

89

British Library Electronic Table of Contents (United Kingdom)

Abstract Four new dimeric naphtho--pyrones, named rubasperone D (1), rubasperone E (2), rubasperone F (3), and its atropisomer rubasperone G (4), together with four known monomeric naphtho--pyrones, TMC 256 A1 (5), rubrofusarin B (6), fonsecin (7), and flavasperone (8), were isolated from the mangrove endophytic fungus Aspergillus tubingensis (GX1-5E) cultivated in solid rice medium. Their structures were elucidated by spectroscopic methods, including IR, 1D- and 2D-NMR, and MS. In the in vitro cytotoxicity assays, 5 displayed inhibitory activities against tumor cell lines of MCF-7, MDA-MB-435, Hep3B, Huh7, SNB19, and U87-MG with IC50 values between 19.92 and 47.98-M. Compounds 1, 6, and 8 also showed mild cytotoxic activity.

2011-01-01

90

Non-toxigenic Clostridium sordellii: Clinical and microbiological features of a case of cholangitis-associated bacteremia

British Library Electronic Table of Contents (United Kingdom)

Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or the tcsH gene for TcsH. In addition, the strain was neither cytotoxic in vitro nor lethal in a murine...

2011-01-01

91

In vitro evaluation of mineral cytotoxicity and inflammatory activity

Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae

Health risks associated with inhalation of mineral dusts have been identified to a great extent through epidemiology studies, but also have been assessed by conducting subchronic and chronic inhalation studies typically on rodents. However, in vivo studies are softly, time-consuming, requiring complex technologies, and may not yield information on cellular and molecular mechanisms of response. As a result, the use of in vitro cell culture systems has played an important role in studying the toxicology of mineral dusts and providing insight into action mechanisms. This article reviews selected in vitro approaches that are used to investigate the cytotoxic and inflammatory properties of mineral particles and fibers. In addition key findings as they relate to understanding the toxicology of mineral dusts are presented. 165 refs., 1 fig., 5 tab.

1993-12-31

92

British Library Electronic Table of Contents (United Kingdom)

Ethnobotanical and chemotaxonomical studies for antiparasitic activity of Colombian Annonaceae were carried out. In vitro antiprotozoal activity of 36 extracts obtained from six different species was determined against promastigotes of three Leishmania species, epimastigotes of Trypanosoma cruzi and both chloroquine sensitive (F32) and resistant (W2) Plasmodium falciparum. Cytotoxic activity was evaluated in U-937 cells. Active extracts were selected according their selectivity index (SI). Extracts from Annona muricata, Rollinia exsucca, Rollinia pittieri and Xylopia aromatica were active against Leishmania spp. and Trypanosoma cruzi showing IC50 values lower than 25mg/ml. Hexane extract from Rollinia pittieri leaves was the most selective against Trypanosoma cruzi and Leishmania spp. (IS=...

2007-01-01

93

Ultrastructure of the spermatozoon of the digenean Cricocephalus albus (Kuhl & van Hasselt, 1822) Looss, 1899 (Platyhelminthes, Pronocephaloidea, Pronocephalidae), parasite of ''the hawksbill sea turtle''Eretmochelys imbricata (Linnaeus, 1766) in Senegal

British Library Electronic Table of Contents (United Kingdom)

The mature spermatozoon of Cricocephalus albus is filiform, tapered at both ends and shows the following features: 2 axonemes of different lengths presenting the 9+''1'' trepaxonematan pattern, 2 bundles of parallel cortical microtubules, a mitochondrion and a nucleus. Nevertheless, the particularity of the spermatozoon of C. albus is its anterior extremity with an apical electron-dense material associated with extramembranar ornamentation, a cytoplasmic dorsolateral expansion and spine-like bodies. To our knowledge, such an anterior extremity of the spermatozoon has not previously been described from a species of the superfamily Pronocephaloidea. Our study provides new data on the mature gamete of C. albus in order to improve our understanding of the pronocephaloidean phylogenetic relatio...

2011-01-01

94

Paralysis due to a glomangioma in a Macaca mulatta. Final report

Extracellular matrix of plant callus tissue visualized by ESEM and SEM

Glomangioma have many synonyms including: glomus tumors, tumors of neuromyoarterial glomi, angioneuromas, angioneuromyomas, neuromyoarterial glomi, painful subcutaneous tubercles, Popoff tumors or subcotaneous glomal tumors. They are common in humans, rare in nonhuman primates and to the best of our knowledge, have only been reported in irradiated rhesus. The neoplasms originate in arterial-venous shunts known as neuromyoarterial glomi which are commonly found beneath fingernails and fingertips, but have been reported in many locations both superficial and deep. The neoplasm can be confused with hemangiopericytomas, hemangiomas, paragangliomas, and leiomyomas, and must be definitely diagnosed ultrastructurally. A glomangioma at the 6-7 thoracic intervertebral space caused compression of the spinal cord with posterior paralysis in an irradiated 20-year-old female rhesus monkey (Macaca mulatta).

1984-01-01

95

British Library Electronic Table of Contents (United Kingdom)

Actinidia deliciosa endosperm-derived callus culture is stable over a long period of culture. This system was used to investigate the ultrastructure of extracellular matrix occurring in morphogenic tissue. Specimens were prepared by different biological techniques (chemical fixation, liquid nitrogen fixation, glycerol substitution, critical-point drying, lyophilization) and observed by scanning electron microscopy (SEM). Fresh and wet samples were analyzed with the use of environmental scanning electron microscopy (ESEM). Extracellular matrix was observed on the surface of cell clusters as a membranous layer or reticulated network, shrunken or wrinkled, depending on the procedure. Generally, shrunken membranous layers with a globular appearance and fibrils were noted after critical-point d...

2010-01-01

96

Establishment of functional primary cultures of heart cells from the clam Ruditapes decussatus

British Library Electronic Table of Contents (United Kingdom)

Heart cells from the clam Ruditapes decussatus were routinely cultured with a high level of reproducibility in sea water based medium. Three cell types attached to the plastic after 2?days and could be maintained in vitro for at least 1?month: epithelial-like cells, round cells and fibroblastic cells. Fibroblastic cells were identified as functional cardiomyocytes due to their spontaneous beating, their ultrastructural characteristics and their reactivity with antibodies against sarcomeric ?-actinin, sarcomeric tropomyosin, myosin and troponin T-C. Patch clamp measurements allowed the identification of ionic currents characteristic of cardiomyocytes: a delayed potassium current (I K?slow) strongly suppressed (95%) by tetraethylammonium (1?mM), a fast inactivating potassium current (I K?fas...

2011-01-01

97

Efficient elimination of sweetpotato little leaf phytoplasma from sweetpotato by cryotherapy of shoot tips

British Library Electronic Table of Contents (United Kingdom)

Shoot tips with 3-4 leaf primordia were excised from in vitro-grown sweetpotato plants (Ipomoea batatas) infected with little leaf phytoplasma (Candidatus Phytoplasma aurantifolia) and subjected to cryotherapy. All plants regenerated from the cryo-treated shoot tips were free of phytoplasma, whereas shoot tip culture or dehydration of shoot tips without subsequent cryotherapy resulted in phytoplasma-free plants at a frequency of only 7-10%. Histological and ultrastructural studies with light and transmission electron microscopy, respectively, indicated that cryotherapy was lethal to all cells except those in the apical dome of the meristem and the two youngest leaf primordia. These surviving parts of the shoot tip contained vascular tissue and sieve elements, but electron microscopy showed...

2008-01-01

98

Biological and morphological characterization of human neonatal fibroblast cell culture B-HNF-1

British Library Electronic Table of Contents (United Kingdom)

In the present study, human neonatal fibroblasts were isolated from a two-month-old human male. The purpose of the present investigation was the analysis of the morphology (light and transmission electron microscopy), karyotype and growth characteristics of the human neonatal fibroblast cell culture B-HNF-1. Moreover, STR typing and mitochondrial DNA amplification and sequencing was also performed. Analysis of chromosomes count showed that B-HNF-1 cell culture is diploid and has normal male karyotype 46, XY, which was stable during cultivation. The transmission electron microscopy demonstrated the ultra-structure of the B-HNF-1 cells; they have typical morphological features of proteosynthesis-active cells. Large number of fibroblasts bearing different shapes and surface characteristics ad...

2010-01-01

99

Studies with 1,2-dithiole-3-thione as a chemoprotector of hydroquinone-induced toxicity to DBA/2-derived bone marrow stromal cells.

Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes.

Stromal cells from DBA/2 mouse bone marrow have been shown to be susceptible to cytotoxicity induced by several redox-active metabolites of benzene, including hydroquinone (HQ). Treatment with HQ also...Full Text Available

1993-06-01

100

NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma

While a great deal of evidence has directly implicated the importance of O6-alkylation of guanine in the mutagenicity of alkylating agents, evidence demonstrating the oncogenic potential of this lesion...Full Text Available

1992-12-01

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101

Monoclonal antibodies to ovine SBU-T8 and SBU-T6 bind analogous molecules on bovine lymphocytes.

Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is an aggressive non-Hodgkin lymphoma of T/null immunophenotype that is most prevalent in children and young adults. The...Full Text Available

2011-02-15

102

Induction of an abortive and futile DNA repair process in E. coli by the antitumor DNA bifunctional intercalator, ditercalinium: role in polA in death induction.

Monoclonal antibodies (mAb) to ovine T-lymphocyte molecules SBU-T8 (Maddox, Mackay & Brandon, 1985), the cytotoxic T lymphocyte, human CD8 equivalent, and SBU-T6 (Mackay et al., 1985), the immature...Full Text Available

1989-06-01

103

Biodegradable Tri-Block Copolymer Poly(lactic acid)-poly(ethylene glycol)-poly(l-lysine)(PLA-PEG-PLL) as a Non-Viral Vector to Enhance Gene Transfection

Ditercalinium, an antitumor bifunctional intercalator which forms a high affinity reversible complex with DNA, was found to be specifically cytotoxic for polA and lig7 E. coli strains. In the polA strain,...Full Text Available

1988-02-11

104

AQ4N: an alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo.

Low cytotoxicity and high gene transfection efficiency are critical issues in designing current non-viral gene delivery vectors. The purpose of the present work was to synthesize the novel biodegradable...Full Text Available

105

??⁺ T-Lymphocyte Cytotoxicity against Envelope-Expressing Target Cells Is Unique to the Alymphocytic State of Bovine Leukemia Virus Infection in the Natural Host

AQ4N (1,4-bis([2-(dimethylamino-N-oxide)ethyl]amino)5,8-dihydroxy- anthracene-9,10-dione) is a novel alkylaminoanthraquinone N-oxide which, on reduction, forms a stable DNA affinic cytotoxic compound...Full Text Available

1995-07-01

106

Structure determination and investigation on cytotoxicity of potassium dichlorido(l-prolinato)platinate(II) versus chlorido(dimethyl sulfoxide)(l-prolinato)platinum(II) complex -In vitro antitumor deactivation by Cl^-/dmso ligand exchange

Bovine leukemia virus (BLV) is a complex B-lymphotrophic retrovirus of cattle and the causative agent of enzootic bovine leukosis. Serum antibody in infected animals does not correlate with protection...Full Text Available

2000-09-01

107

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Potassium dichlorido(l-prolinato)platinate(II), K[PtCl"2(l-pro"?"H)] (1), and chlorido(dimethyl sulfoxide)(l-prolinato)platinum(II), [PtCl(l-pro"?"H)(dmso)] (2), were synthesized by ligand substitution reactions. Both complexes were characterized by ^1H, ^1^3C, and ^1^9^5Pt NMR spectroscopy, elemental analysis, and HR-ESI-MS. The molecular structures of 1 and 2 were determined by single crystal X-ray diffraction, proving bidentate coordinated l-prolinato ligand and SP-4-4 configuration of 2a. With the help of DFT calculations stability of possible isomers of 1 and 2 was studied. A considerable difference in the in vitro cytotoxicity of 1 versus 2a (exchange of one chlorido ligand by dmso) against four human cancer cell lines was found.

2011-01-01

108

Cellular uptake of Aib-containing amphipathic helix peptide.

A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1a-mediated signaling

Cell-penetrating peptides (CPPs) are useful tools for the delivery of hydrophilic bioactive molecules, such as peptides, proteins, and oligonucleotides, across the cell membrane. To realize the delivery of therapeutic macromolecules by CPPs, the CPPs are required to show resistance to protease and no cytotoxicity. In order to produce potent non-toxic and protease-resistant CPPs with high cellular uptake, we designed an amphipathic helix peptide using ?-aminoisobutyric acid (Aib, U) and named it MAP(Aib). In the MAP(Aib) molecule, five Aib residues are aligned on the hydrophobic face of the helix and five lysine (K) residues are aligned on the hydrophilic face. MAP(Aib) showed potent resistance to trypsin and pronase compared with MAP, an amphipathic helix peptide formed by usual amino acids. Fluorescein-labeled MAP(Aib) efficiently traversed the A549 cell membrane, diffusing into the cytoplasm and slightly into the nucleus without exerting any ...

2011-08-11

109

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Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) chemicals are antitumor antibiotics inhibiting nucleic acid synthesis. An indole carboxylate-PBD hybrid with six-carbon spacer structure (IN6CPBD) has been previously demonstrated to induce melanoma cell apoptosis and reduce metastasis in mouse lungs. This study aimed at investigating the efficacy of the other hybrid compound with four-carbon spacer (IN4CPBD) and elucidating its anti-metastatic mechanism. Human melanoma A375 cells with IN4CPBD treatment underwent cytotoxicity and apoptosis-associated assays. Transwell migration assay, Western blotting, and ELISA were used for mechanistic study. IN4CPBD exhibited potent melanoma cytotoxicity through interrupting G1/S cell cycle progression, increasing DNA fragmentation and hypodipoidic DNA contents, a...

2011-01-01

110

Two new paeciloxocins from a mangrove endophytic fungus Paecilomyces sp.

British Library Electronic Table of Contents (United Kingdom)

Paeciloxocins A and B (2-(1-hydroxy-3-methylbutyl)- and 2-(1-acetoxy-3-methylbutyl)- 11-hydroxy-9-methyl-1-methoxy-5H,7H-dibenzo[b,g]-1,5-dioxocin-5-ones), viz., two new metabolites, were isolated from the mangrove fungus Paecilomyces sp. collected from the Taiwan Strait. Their structures were elucidated by spectral methods. Paeciloxocin A exhibited strong cytotoxicity against the hepG2 cell line.

2010-01-01

111

Topoisomerases of kinetoplastid parasites: why so fascinating?

British Library Electronic Table of Contents (United Kingdom)

Summary DNA topoisomerases are the key enzymes involved in carrying out high precision DNA transactions inside the cells. However, they are detrimental to the cell when a wide variety of topoisomerase-targeted drugs generate cytotoxic lesions by trapping the enzymes in covalent complexes on the DNA. The discovery of unusual heterodimeric topoisomerase I in kinetoplastid family added a new twist in topoisomerase research related to evolution, functional conservation and their preferential sensitivity to Camptothecin. On the other hand, structural and mechanistic studies on kinetoplastid topoisomerase II delineate some distinguishing features that differentiate the parasitic enzyme from its prokaryotic and eukaryotic counterparts. This review summarizes the recent advances in research in kin...

2006-01-01

112

Synthesis and Biophysical Characterization of Chlorambucil Anticancer Ether Lipid Prodrugs

Solid-phase synthesis and pharmacological evaluation of novel nucleoside-tethered dinuclear platinum(II) complexes

The synthesis and biophysical characterization of four prodrug ether phospholipid conjugates are described. The lipids are prepared from the anticancer drug chlorambucil and have C16 and C18 ether chains with phosphatidylcholine or phosphatidylglycerol headgroups. All four prodrugs have the ability to form unilamellar liposomes (86-125 nm) and are hydrolyzed by phospholipase A2, resulting in chlorambucil release. Liposomal formulations of prodrug lipids displayed cytotoxicity toward HT-29, MT-3, and ES-2 cancer cell lines in the presence of phospholipase A2, with IC50 values in the 8-36 ?M range.

2009-01-01

113

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Three novel inosine-based dinuclear platinum complexes have been synthesized via a solid-phase strategy. In these compounds, the metal is linked both to the N-7 of the purine nucleus and to the terminal amine group of a hexylamine side chain installed on N-1. Cis- or trans- diamine as well as ethylenediamine ligands are coordinated to platinum along with a chloride. The synthesised complexes were tested against four different human tumor cell lines. One of these complexes proved to be more cytotoxic than cisplatin against the MCF7 cancer cell line in a short-term exposure assay.

2011-01-01

114

Monoclonal antibodies to antigens on human neutrophils, activated T lymphocytes, and acute leukemia blast cells

Antitumor activity of platinum(II) complexes with histamine and radioiodinated histamine in a transplantable murine adenocarcinoma model

The authors describe the production of two mouse hybridomas secreting monoclonal antibodies to antigenic determinants of the surface membranes of human neutrophils, activated T lymphocytes, and acute leukemic blast cells. The degree of lymphocyte stimulation was estimated from incorporation of /sup 3/H-thymidine with parallel microculture. Monoclonal antibodies of supernatants of hybridoma cultures shown here reacted in both immunofluorescence test and cytotoxicity test with surface membrane antigens on the majority of neutrophils and PHA-activated peripheral blood lymphocytes from healthy subjects, but did not give positive reactions with unactivated lymphocytes, adherent monocytes, erythrocytes, and alloantigen-stimulated lymphocytes.

1987-11-01

115

Morphological and molecular redescription of the myxozoan Unicapsula pflugfelderi from two teleost hosts in the Mediterranean. A review of the genus Unicapsula Davis 1924

Purpose: Antitumor activity of the dichloroplatinum(II)-histamine complexes labeled with I-125 or I-131 was investigated in a transplantable murine adenocarcinoma (MA) model. Methods: The tumor model was obtained in C3H/W female mice after subcutaneous inoculation of the tumor cells derived from the mice bearing a mammary tumor of spontaneous origin. Antitumor activities of the platinum-histamine complexes were investigated in three independent experiments, which differed in applied doses of preparations (PtCl{sub 2}Hist, PtCl{sub 2}[{sup 125}I]Hist, PtCl{sub 2}[{sup 131}I]Hist, PtCl{sub 2}Hist/PtCl{sub 2}[{sup 125}I]Hist and PtCl{sub 2}Hist/PtCl{sub 2}[{sup 131}I]Hist), treatment schedules as well as stages of the disease progress in the animals used. Experiment 1 included long-term, multidose treatment with low single doses (treatment duration 31-32 days; 8-10 doses of ca. 0.25{center_dot}MTD{sub Pt} each). Experiment 2 included short-term, multidose treatment with higher single ...

2008-07-15

116

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Abstract Elongate plasmodia with myxosporean spores belonging to the genus Unicapsula, Davis, 1924 were found in the skeletal muscle of the striped seabream, Lithognathus mormyrus (L.), a candidate for the mediterranean aquaculture. The only species of Unicapsula described from the Mediterranean is Unicapsula pflugfelderi Schubert et al. 1975, which occurs in the picarel, Spicara smaris (L.). For morphological and molecular comparison of U. pflugfelderi from S. smaris with Unicapsula sp. from L. mormyrus measurements of plasmodia and spores, ultrastructural details and 18S and 28S rDNA sequences were analysed. Whereas plasmodia were 2-3 times larger in S. smaris than in L. mormyrus (length 2.47-0.81 mm; width 0.22-0.09 mm; P = 0.000), spore morphology showed minor differences and both 18S ...

2009-01-01

117

Influence of substrates on nitrogen removal performance and microbiology of anaerobic ammonium oxidation by operating two UASB reactors fed with different substrate levels.

Erratum to: Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica

Both ammonium and nitrite act as substrates as well as potential inhibitors of anoxic ammonium-oxidizing (Anammox) bacteria. To satisfy demand of substrates for Anammox bacteria and to prevent substrate inhibition simultaneously; two strategies, namely high or low substrate concentration, were carefully compared in the operation of two Anammox upflow anaerobic sludge blanket (UASB) reactors fed with different substrate concentrations. The reactor working at relatively low influent substrate concentration (NO(2)(-)-N, 240 mg-NL(-1)) was shown to avoid the inhibition caused by nitrite and free ammonia. Using the strategy of low substrate concentration, a record super high volumetric nitrogen removal rate of 45.24 kg-Nm(-3) day(-1) was noted after the operation of 230 days. To our knowledge, such a high value has not been reported previously. The evidence from transmission electron microscopy (TEM) showed that the morphology and ultrastructure of the Anammox cells in ...

2010-04-13

118

British Library Electronic Table of Contents (United Kingdom)

A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of drug metabolism. The cytochrome P450 (CYP 450) enzyme pathway was inhibited using ketoconazole (KTZ) to see whether a TCBZ-resistant isolate could be made more sensitive to TCBZ action. The Oberon TCBZ-resistant and Cullompton TCBZ-susceptible isolates were used for these experiments. The CYP 450 system was inhibited by a 2-h pre-incubation in ketoconazole (40??M), then incubated for a further 22?h in NCTC medium containing either KTZ, KTZ?+?nicotinamide adenine dinucleotide phosphate (NADPH) (1?nM), KTZ?+?NADPH?+?TCBZ (15??g/ml), or KTZ?+?NADPH?+?triclabendazole sulphoxide (TCBZ.SO; 15??g/ml). Changes to fluke ultrastructure following drug treatmen...

2011-01-01

119

Tumor necrosis factor-? is associated with positive lymph node status in patients with recurrence of colorectal cancer?indications for anti-TNF-? agents in cancer treatment

British Library Electronic Table of Contents (United Kingdom)

Introduction The progressive growth of malignancies is accompanied by a decline in the immune response through mechanisms which are poorly understood. Apoptosis and induction of inflammation by tumor released cytokines as tumor escape mechanisms have been proposed to play an important role in colorectal carcinogenesis. Methods Expression of Tumor necrosis factor-alpha (TNF-?) was analyzed in colorectal cancer specimen and the cancer cell line HT-29 by immunohistochemistry and RT-PCR. TNF-? expression on protein and mRNA level were correlated with clinical characteristics and impact on survival. TNFR-1 was co-labelled with TNF-? and CD8+ cytotoxic T cells in immunofluorescence double staining experiments. Results: 94% (n?=?98/104) of the patients with CRC expressed TNF-?. High TNF-? express...

2011-01-01

120

Stress-induced martensitic transformation of metastable #beta#-titanium alloy

Resveratrol Potentiates the Cytotoxic Oxidative Stress Induced by Chemotherapy in Human Colon Cancer Cells

The constituent phases and associated deformed microstructure of the quenched Ti-xNb-(0.5-1.5) at.% Si alloy consisting of non-cytotoxicity elements, where x = 24-30 at.%, were investigated to provide pseudoelasticity for biomedical and sensor applications. Optical microscopy revealed that stress-induced martensitic transformation takes place during the deformation in the present alloys. It is confirmed from the X-ray diffraction results of the deformed specimens that the crystal structure of the stress-induced martensite phase is the orthorhombic so-called #alpha#'' structure. Within the alloys having #beta#(bcc) phase studied Nb-poor region appeared to exhibit a dominant behavior for stress-induced martensitic transformation than Nb-rich region. This result suggests that metastable #beta# phase is superior to stable #beta# phase for the occurrence of stress-induced martensitic transformation in the present alloy system.

2007-03-25

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Abstract The treatment of advanced colorectal cancer with 5-fluorouracil has two major problems: development of tumor resistance and toxicity toward normal tissues. The aim of this study was to investigate the possible advantages of combining 5-fluorouracil (5-FU) with resveratrol (trans-3, 4prime, 5-trihydroxystilbene) for treating HT-29 and SW-620 colorectal carcinoma cell lines. Since combined treatment using 5-FU with resveratrol resulted in a significant decrease in long-term cell survival, we investigated the possible basis of this synergistic interaction at a molecular level, focusing on oxidative stress as a possible mediator of cell death. Resveratrol established interactions with the mitochondria of cancer cells and induced an imbalance in cellular antioxidant activities, leading...

2011-01-01

122

Premnalatifolin A, a novel dimeric diterpene from Premna latifolia Roxb

British Library Electronic Table of Contents (United Kingdom)

Premnalatifolin A (1), a unique icetexane diterpene dimer was isolated from the stem-bark of Indian medicinal plant, Premna latifolia. Its structure and relative stereochemistry were elucidated on the basis of detailed spectroscopic analysis, including HRESIMS and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectra. The compound has dimeric carbon skeleton composed of two icetexane skeletal diterpenes linked via ether bond. Further, premnalatifolin A (1) was also evaluated for its cytotoxicity against cancer cell lines (HT-29, A-431, MCF-7, Hep-G2, PC-3, A-549, B-16 F10, and ACHN), which displayed potent activity against HT-29 and MCF-7 cell lines with the IC50 values of 12.15 and 1.11mg/mL, respectively.

2011-01-01

123

Ovis aries CR4 is involved in Mannheimia haemolytica leukotoxin-induced cytotoxicity

British Library Electronic Table of Contents (United Kingdom)

Pneumonia caused by Mannheimia haemolytica is an important disease of domestic sheep (DS, Ovis aries) and cattle (BO). M. haemolytica is a normal commensal of the upper respiratory tract in ruminants, but during stress and viral infection it breaches the host innate mucosal defense and descents into lungs causing fibrinous pleuropneumonia. Leukotoxin (Lkt) produced by M. haemolytica is cytolytic to all subsets of ruminant leukocytes. Earlier, we and others have shown that DS and BO LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) can mediate Lkt-induced cytolysis. It is not clear whether CR4 (CD11c/CD18), which is involved in chemotaxis, phagocytosis and regulates host immune response can also mediate Lkt-induced cytolysis in ruminants. The host innate immune response to M. haemolytica is poorly ...

2010-01-01

124

Decreased semen quality in a male infected with malaria.

Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi.

A 33-year-old male of proven fertility suffered six attacks of malaria while resident in an African country. For this he received anti-malarial drugs. Semen analysis performed after the fourth attack, and repeated during the following 2 years after his return to Israel, revealed severe oligozoospermia, necrozoospermia and occasionally even azoospermia. Immunological examination of the patient revealed an inverse ratio of T-cell subsets and mast cell degranulation in response to palludrin. Twenty-five months after the last attack of malaria a significant improvement was found in semen quality and there was an increase in the ratio of T-helper to T-suppressor cytotoxic cells. These observations indicate that although malaria and its treatment may affect spermatogenesis, recovery may be expected eventually. PMID:3500921

1987-10-01

125

A new method for quantifiable and controlled dosage of particulate matter for in vitro studies: The electrostatic particulate dosage and exposure system (EPDExS)

In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC(50) values of 3.17 and 3.21 microM to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed. PMID:20479985

2010-04-23

126

British Library Electronic Table of Contents (United Kingdom)

An exposure chamber is described for the quantifiable addition of fine and ultrafine aerosol particulate matter directly to cells and used to demonstrate the in vitro cytotoxicity of fine 1,4-naphthoquinone particles to murine lung epithelial cells. The electrostatic particulate dosage and exposure system (EPDExS) operates on the principle of electrostatic precipitation and is shown to deposit fine and ultrafine aerosol particles directly to cells with 100% efficiency for particle diameters in the range of 40-530nm. This range is not limited by the EPDExS, but rather by the aerosolization method used for this study. Numbers of particles deposited onto the cells are counted with a condensation particle counter, negating any need to calculate or estimate particle exposure. The process of par...

2008-01-01

127

A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens, and carp

British Library Electronic Table of Contents (United Kingdom)

T-2 toxin, a highly toxic member of the type-A trichothecenes, is produced by various Fusarium moulds that can potentially affect human health. It is strongly cytotoxic for human hematopoietic progenitors. Alimentary toxic aleukia (ATA), a disease typically associated with human, is primarily induced by T-2 toxin. A comparison of the metabolism of T-2 toxin incubated with hepatocytes of rats, piglets, chickens, and the hepatic subcellular fractions (microsomes and cytosol) of piglets, chickens, rats, and carp (common carp and grass carp) was carried out. The activities of the recombinant pig CYP3A29 on the transformation of T-2 and HT-2 toxins were preliminary studied. Metabolites were identified by novel LC/MS-IT-TOF. Qualitative similarities and differences across the species were observ...

2011-01-01

128

A Hypothesis: Supplementation with Mushroom-Derived Active Compound Modulates Immunity and Increases Survival in Response to Influenza Virus (H1N1) Infection.

Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat

We hypothesize that the mushroom-derived active compound may be a potential strategy for increasing survival in response to influenza virus (H1N1) infection through the stimulation of host innate immune response. The validity of the hypothesis can be tested by immune response to influenza infection as seen through survival percentage, virus clearance, weight loss, natural killer cell cytotoxicity, Tumor Necrosis Factor-? (TNF-?) and Interferon-gamma (IFN-?) levels, lytic efficiency in the spleens of mice and inducible nitric oxide synthase mRNA expressions in RAW 264.7 murine macrophage cells. The hypothesis may improve people's quality of life, reduce the medical cost of our healthcare system and eliminate people's fears of influenza outbreak. PMID:21660092

2011-03-20

129

Primary gonadal damage following treatment of brain tumors in childhood

Paraquat (1,1'-dimethyl-4,4'-bipyridinium) is a widely used herbicide known to induce skin toxicity. This is thought to be due to oxidative stress resulting from the generation of cytotoxic reactive oxygen intermediates (ROI) during paraquat redox cycling. The skin contains a diverse array of antioxidant enzymes which protect against oxidative stress including superoxide dismutase (SOD), catalase, glutathione peroxidase-1 (GPx-1), heme oxygenase-1 (HO-1), metallothionein-2 (MT-2), and glutathione-S-transferases (GST). In the present studies we compared paraquat redox cycling in primary cultures of undifferentiated and differentiated mouse keratinocytes and determined if this was associated with oxidative stress and altered expression of antioxidant enzymes. We found that paraquat readily undergoes redox cycling in both undifferentiated and differentiated keratinocytes, generating superoxide anion and hydrogen peroxide as well as increased protein oxidation which ...

2008-09-15

130

New Lactone and Xanthone Derivatives Produced by a Mangrove Endophytic Fungus Phoma sp. SK3RW1M from the South China Sea

Gonadal function was studied in two groups of children previously treated for medulloblastoma with surgery followed by postoperative craniospinal irradiation. In group 1 but not in group 2, the children also received adjuvant chemotherapy for one to two years. All children in group 1 received a nitrosourea (BCNU or CCNU), plus vincristine in four and procarbazine in three patients. The nine children in group 1 showed clinical and biochemical evidence of gonadal damage with elevated serum FSH concentrations and, in the boys, small testes for their stage of pubertal development. In group 2 (n . 8), each child had completed pubertal development normally, the boys had adult sized testes and the girls regular menses. Gonadotropin values were normal in all eight children. We conclude that nitrosoureas were responsible for the gonadal damage in the children in group 1, with procarbazine also contributing to the damage in the three children who received this drug. In view of the limited proved ...

1983-10-01

131

British Library Electronic Table of Contents (United Kingdom)

A new lactone, 1,8-dihydroxy-10-methoxy-3-methyldibenzo[b,e]oxepine-6,11-dione (1), and two new xanthones, 1-hydroxy-8-(hydroxymethyl)-6-methoxy-3-methyl-9H-xanthen-9-one (2) and 1-hydroxy-8-(hydroxymethyl)-3-methoxy-6-methyl-9H-xanthen-9-one (3), were isolated from a mangrove endophytic fungus Phoma sp. SK3RW1M collected from the South China Sea. This is the first report on xanthone derivatives isolated as secondary metabolites from Phoma species. Their structures were elucidated by spectroscopic methods, mainly 1D- and 2D-NMR techniques, and the structure of compound 2 was confirmed by X-ray crystallography. Cytotoxicity assays showed that compounds 1-3 were inactive against KB and KBv200 cells.

2010-01-01

132

Highly Porous, Water-Soluble, Superparamagnetic, and Biocompatible Magnetite Nanocrystal Clusters for Targeted Drug Delivery.

Formation of colloidal silver nanoparticles stabilized by Na+-poly(gamma-glutamic acid)-silver nitrate complex via chemical reduction process.

Magnetic particles have become very promising materials for drug delivery. However, preparation of magnetite particles with high surface area, biocompatibility, strong magnetic response, and suitable particle size still remains a major challenge. In this report, magnetite nanocrystal clusters with high surface areas were fabricated through a solvothermal process by introducing ammonium acetate as a porogen and trisodium citrate as a surface modification agent. The porosity, which was controlled by the reactant concentration, has been investigated in detail. The surface area of the nanocrystal clusters was as high as 141?m(2) g(-1) . Ibuprofen, as a model drug, was entrapped into the magnetite carriers. The interfacial interaction between the carboxylic groups on the drug molecules and the carboxylate groups on the carriers enhanced the loading efficiency. Low cytotoxicity in MCF-7 cell and in vitro constant drug release behavior combined with the high drug loading ...

2011-09-27

133

Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells

Macromolecular and polyanionic Na(+)-poly(gamma-glutamic acid) (PGA) silver nitrate complex acted as both a metal ion provider and a particle protector to fabricate nanosized silver colloids under chemical reduction by dextrose. The formation and size of particles have been characterized from transmission electron microscopy (TEM), dynamic light scattering analysis and UV-vis spectrophotometer. The results showed that the average particle size was 17.2+/-3.4 to 37.3+/-5.5 nm, apparently depending on the complex concentration. It was found that the rate constant and conversion of silver nanoparticles were proportional to the concentration of PGA. The growth mechanism of nanosized silver colloid was fully discussed. In addition, the in vitro cytotoxicity evaluated by L929 fibroblasts proliferation and antibacterial activity against Gram-positive strain (methicillin-resistant S. aureus (MRSA)) and Gram-negative strain (P. aeruginosa) bacteria have been assessed. ...

2007-05-18

134

British Library Electronic Table of Contents (United Kingdom)

Aims: In this study we investigated whether attenuation of endoplasmic reticulum stress (ER stress) could protect HepG2 cells from free fatty acid (FFA)-induced apoptosis. Main methods: Human liver cell line HepG2 cells were exposed to Sodium Palmitate (Pa) or Sodium Oleate (Ol). Apoptosis and ER stress of HepG2 cells were analyzed with flow cytometry, real-time RT-PCR and Western Blotting. An expression plasmid encoding for the ER chaperone immunoglobulin heavy chain-binding protein (Bip) was transfected into HepG2 cells to attenuate ER stress. Small interfering RNA siCHOP was used to knockdown the expression of C/EBP Homologous Protein (CHOP) in HepG2. Key findings: Pa led to cytotoxicity and apoptosis in HepG2 cells in a dose-dependent pattern and also induced ER stress indicated by inc...

2010-01-01

135

Antioxidant and toxicity tests of roasted noni (Morinda citrifolia) leaf infusion

British Library Electronic Table of Contents (United Kingdom)

Summary The antioxidant properties and toxicity profile of roasted noni (Morinda citrifolia L.) leaf infusion were evaluated. The 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging activity was greater than green tea infusion (81.6 +- 0.9% vs. 57.5 +- 1.8%, P < 0.001). The mean quercetin and kaempferol contents of roasted noni leaf infusion, as prepared by the consumer, were 0.24 +- 0.01 and 0.14 +- 0.01 mg mL-1, respectively. Tannic acid content was 10 +- 1 mg mL-1. The infusion was non-mutagenic in the reverse mutation test in Salmonella typhimurium and did not induce primary DNA damage in E. coli PQ37. Further, no significant primary DNA damage was induced by 5,15-dimethylmorindol, which was the only detectable anthraquinone in noni leaves. The infusion was not cytotoxic in the 24 h b...

2009-01-01

136

A CD33-specific single-chain immunotoxin mediates potent apoptosis of cultured human myeloid leukaemia cells.

The characteristics of a hydroxyapatite-chitosan-PMMA bone cement.

A novel single-chain immunotoxin was constructed by combining a CD33-specific single chain Fv (scFv) antibody fragment with an engineered variant of Pseudomonas exotoxin A (ETA). The variant toxin carries the KDEL peptide at its C-terminus, a cellular peptide mediating improved retrograde transport to the endoplasmic reticulum. The purified recombinant fusion protein induced potent apoptosis of the human myeloid cell lines U937, HL-60 and THP-1. Up to 98% of U937 cells were eliminated after treatment for 72 h with a single dose of 500 ng/ml (c. 7 nmol/l). Killing was antigen-specific and occurred by apoptosis. A control protein, consisting of a CD19-specific scFv antibody fragment fused to the ETA-KDEL toxin, failed to induce death of the CD19-negative cell lines U937, HL-60 and THP-1. The CD33-ETA toxin also mediated apoptosis of fresh patient-derived acute myeloid leukaemia cells from bone marrow and peripheral blood. The pronounced antigen-restricted ...

2006-04-01

137

Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes {sup 203}Pb and {sup 212}Pb

In this study, we propose a new bioactive bone cement (BBC), composed of natural bone powder (hydroxyapatite; HA), chitosan powder, and the currently available polymethylmethacrylate (PMMA) bone cement, for use in orthopedic surgeries such as vertebroplasty or as bone filler. Three types of BBCs (BBC I, BBC II, and BBC III) were prepared with different composition ratios. In vitro tests and animal studies were performed with the new BBCs, and with a currently available commercial PMMA bone cement. Surface morphology, chemical composition, changes in pH over time, exothermic temperatures, intrusion, and cellular responses were investigated in vitro. Scanning electron microscopy (SEM) and radiological and histological examinations were performed in animal studies. The results showed that the major components of the BBCs were C, O, Ca, P, Cl, Si, S, Ba, and Mg. The pH values of the BBCs decreased after 1 day, but eventually recovered to 7.2-7.4. The water absorbency, weight loss, and ...

2004-11-01

138

Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes "2"0"3Pb and "2"1"2Pb

Radioisotopes of Pb(II) have been of some interest in radioimmunotherapy and radioimmunoimaging (RII). However, the absence of a kinetically stable bifunctional chelating agent for Pb(II) has hampered its use for these applications. {sup 203}Pb (T{sub 1/2}=52.02 h) has application potential in RII, with a {gamma}-emission that is ideal for single photon emission computerized tomography, whereas {sup 212}Pb (T{sub 1/2}=10 h) is a source of highly cytotoxic {alpha}-particles via its decay to its {sup 212}Bi (T{sub 1/2}=60 min) daughter. The synthesis of the novel bifunctional chelating agent 2-(4-isothiocyanotobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoyl methyl)-cyclododecane (4-NCS-Bz-TCMC) is reported herein. The Pb[TCMC]{sup 2+} complex was less labile to metal ion release than Pb[DOTA]{sup 2-} at pH 3.5 and below in isotopic exchange experiments. In addition to increased stability to Pb{sup 2+} ion release at low pH, the bifunctional TCMC ligand was ...

2000-01-01

139

Status of lead and bismuth for radioimmunoimaging and radioimmunotherapy

Radioisotopes of Pb(II) have been of some interest in radioimmunotherapy and radioimmunoimaging (RII). However, the absence of a kinetically stable bifunctional chelating agent for Pb(II) has hampered its use for these applications. "2"0"3Pb (T_1_/_2=52.02 h) has application potential in RII, with a #gamma#-emission that is ideal for single photon emission computerized tomography, whereas "2"1"2Pb (T_1_/_2=10 h) is a source of highly cytotoxic #alpha#-particles via its decay to its "2"1"2Bi (T_1_/_2=60 min) daughter. The synthesis of the novel bifunctional chelating agent 2-(4-isothiocyanotobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoyl methyl)-cyclododecane (4-NCS-Bz-TCMC) is reported herein. The Pb[TCMC]"2"+ complex was less labile to metal ion release than Pb[DOTA]"2"- at pH 3.5 and below in isotopic exchange experiments. In addition to increased stability to Pb"2"+ ion release at low pH, the bifunctional TCMC ligand was found to have many other ...

2000-01-01

140

Preparation of a high specific activity I-125 labeled styryl dye for leukocyte membrane labeling

Tumor-targeted monoclonal antibodies (mAb) might be useful as diagnostic or therapeutic agents when linked to cytotoxic or imaging reagents. Our group is working to test this hypothesis by linking cytocidal and image-producing isotopes to mAb and testing the utility of the radioimmunoconjugates formed in animal model systems. Radioiodines were first employed for these purposes,but unfavorable nuclear properties (half-lives, #gamma#-ray and #beta#-particle energies) and chemical reactivity (deiodination in vivo) limit their utility. Labeling immunoproteins with metallic radionuclides offers more versatility in that the selection of potentially useful radiometals spans the periodic table.Of the metallic radionuclides with physical properties most suited for use with mAb in nuclear medicine, few are more available or desirable than those of bismuth ("2"1"2Bi) and lead ("2"0"3Pb, "2"1"2Pb), as listed in Table 1. "2"1"2Bi or "2"1"2Pb could serve as sources for highly ...

1990-08-26

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

141

Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening.

The purpose of this work was to develop a high specific activity radioiodinated cell membrane probe for tracking lymphocytes in-vivo to replace the nucleus localizing, cytotoxic lipophilic chelates (In-111 oxine and Tc-99m HMPAO) currently used. Alkylation of parent dye 4-[2-[-N,N-didecylamino]phenyl]ethenyl pyridine with E-1-tributylstannyl-3-tosylpropene (prepared form E-1-tributylstannyl-1-propene-3-ol), gave a tributyltin precursor 1. Radiolabeled 3-[4-[2-[4-(N,N-didecylamino)phenyl]ethenyl]pyridino] E-[I-125]-1-iodopropene (2), was prepared from 1 using peracetic acid in acetonitrile/water. Labeling yields and specific activities achieved were 26% (#approx#2170 Ci/mmol), 40% (1220 Ci/mmol), and 55% (200 Ci/mmol) for nca, 0.4, and 2 nanomole carrier iodide runs respectively. Canine mixed leukocytes (0.5-1.0 x 10"8 cells) were labeled with 2 (67% and 42% yields for 200 Ci/mol and 1220 Ci/mmol preparations) and showed blood clearance similar to In 111 oxine. ...

1994-08-21

142

Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers.

The steroidogenic factor 1 (SF-1, also known as NR5A1) is a transcription factor belonging to the nuclear receptor superfamily. Whereas most of the members of this family have been extensively characterized, the therapeutic potential and pharmacology of SF-1 still remains elusive. Described here is the identification and characterization of selective inhibitory chemical probes of SF-1 by a rational ultra-high-throughput screening (uHTS) strategy. A set of 64,908 compounds from the National Institute of Health's Molecular Libraries Small Molecule Repository was screened in a transactivation cell-based assay employing a chimeric SF-1 construct. Two analogous isoquinolinones, ethyl 2-[2-[2-(2,3-dihydro-1,4-benzodioxin-7-ylamino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoate (SID7969543) and ethyl 2-[2-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoate and (SID7970631), were identified as potent submicromolar inhibitors, yielding IC(50) values of 760 and ...

2008-03-11

143

Cytopathic Effects of Viruses Protocols

Autoreactive cytotoxic CD8 T-cells (CTLs) play a key pathogenic role in the destruction of insulin-producing beta-cells resulting in type 1 diabetes. However, knowledge regarding their targets is limited, restricting the ability to monitor the course of the disease and immune interventions. In a multi-step discovery process to identify novel CTL epitopes in human preproinsulin (PPI), PPI was digested with purified human proteasomes, and resulting COOH-fragments aligned with algorithm-predicted HLA-binding peptides to yield nine potential HLA-A1, -A2, -A3 or -B7-restricted candidates. An UV-exchange method allowed the generation of a repertoire of multimers including low-affinity HLA-binding peptides. These were labeled with quantum dot-fluorochromes and encoded in a combinatorial fashion, allowing parallel and sensitive detection of specific, low-avidity T-cells. Significantly increased frequencies of T-cells against four novel PPI epitopes (PPI(4-13)/B7, ...

2011-05-31

144

Gastric stromal tumors. CT findings; Tumori stromali gastrici. Aspetti con Tomografia Computerizzata

Protocols for using Cytopathic Effects of Viruses

2007-09-29

145

Effect of Pressures up to 2.0 GPa on the Mechanical ...

Gastric stromal tumors are an ill-defined group of lesions arising from muscle wall cells and characterized by extremely variable biological patterns. Thanks to modern immunohistochemical and ultrastructural techniques, four main classes of these lesions have been identified, namely: (1) tumors with differentiation toward smooth muscle cells; (2) tumors with differentiation toward neural elements; (3) tumors with differentiation toward neural elements; (3) tumors with dual differentiation toward either cell type. It was investigated the yield of CT in diagnosing and characterizing gastric stromal tumors. It was retrospectively reviewed the CT findings of 38 patients (15 men and 23 women; mean age 51 years) with pathologically proven gastric stromal tumors, namely 31 of myoid origin, 4 of neural origin, 2 with both muscle and neural differentiation, 1 lacking differentiation with either cell type. The myoid tumors involved gastric fundus in 9/13 and 5/7 benign ...

2000-02-01

146

[Effect of disulfiram on liver function].

... hydrostatic pressures up to 700 MPa. The effect of pressure on the ultimate compressive strength is shown. The effect of size on ...

147

Trust on Superiors and Organizational Effectiveness

PMID:3726630

1986-01-01

148

Irradiation effects on electronic functional materials

Full Text Available

2007-03-01

149

Irradiation effect of laser on salivary glands

No abstract prepared

1998-01-01

150

Effects and side-effects of integrating care: the case of mental health care in the Netherlands

Short communication.

1995-04-01

151

Solar wind effect on the muon flux at sea level

PurposeDescription and analysis of the effects and side-effects of integrated mental health care in the Netherlands.Context of caseDue...Full Text Available

152

Solar wind effect on the muon flux at sea level

2005-01-01

153

New Effective Pesticides

The Effect of Morpholine/Boric Acid/Hydrazine Chemistry on ...

Development the New Effective Pesticides in the Series of Pyrimine and Sym-Triazine Derivatives

154

Electromagnetic Effects Requirements for Systems.

... the effect of MBH on steam generator crevice corrosion; model boiler test results show that MBH is effective against denting corrosion and Alloy 600 ...

155

A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine

This standard establishes requirements, verification criteria, and contractor tasks for electromagnetic effects protection of airborne, ground, and support systems. These effects include electromagnetic compatibility, electromagnetic interference, lightni...

1993-01-01

156

[Occupational harmful effects in descalers and deburrers in the metallurgical industry].

RationaleProcedures for studying the effects of medications on satiation will assist the development of obesity medications.ObjectivesFull Text Available

2008-09-01

157

Thermal Effects on Thin Laser-Peened Ferritic-Martensitic Samples

PMID:5089231

1971-03-01

158

The effects of nozzle geometry on waterjet breakup at high Reynolds numbers

Abstract not provided

2007-05-17

159

The effectiveness of storage and relocation options in renewable energy systems

Not Available

2003-01-01

160

The Emergence of Behavioral Testing of Fishes to Measure Toxicological Effects

Udgivelsesdato: JUL

2008-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

The Effects of Drying Conditions on the Germination Properties of Rapeseed

Full Text Available

2009-03-01

162

The Effect of Simulated Acid Rain on the Growth of Important Crops

Full Text Available

2009-02-01

163

The Destruction Effects of Semiconductors by High Power Electromagnetic Wave

Full Text Available

1998-04-01

164

Synthesis and antimicrobial effects of colloidal silver nanoparticles in chitosan by?-irradiation

Full Text Available

2007-09-01

165

Superconductors for Power Transmission and Distribution

Not Available

2010-04-01

166

ScienceCinema

...the effects of global warming ...

167

Studies on the Effect of Spices and Flavoring on Ascorbic Acid content

Some effects of the plasma nitriding process on layer properties

Full Text Available

1974-03-01

168

Search for Medicinal Plants on Improvable Effect of Intestinal Microflora

Not Available

1992-09-01

169

Screening of Multifunctional Bacteria with Biocontrol and Biofertilizing Effects

Full Text Available

2007-02-01

170

Remifentanil-induced pronociceptive effect and its prevention with pregabalin.

Full Text Available

2011-08-01

171

Remark on the effect of varying density of states in superconducting A-15 compounds

Full Text Available

2011-03-01

172

Recoil Effects of Neutron-Irradiated Metal Permanganates

Not Available

1982-03-01

173

Physical Characteristics and Antagonistic Effect of Ampelomyces

Full Text Available

1988-06-01

174

Monitoring station for medical effects of exposure during radiation accidents

Full Text Available

2009-12-01

175

Evaluation of Subway Induced Vibration Effects on Building Structures

Short communication.

1995-04-06

176

Effects of Preemptive Gabapentin on Postoperative Pain after Mastectomy

Full Text Available

2008-10-01

177

Effects of Opuntia ficus-indica on Lipidperoxide and cholesterol level

Full Text Available

2004-10-01

178

Effects of Licorice on Embryonic and Fetal Development in Rats

Full Text Available

2003-12-01

179

Effects of Antioxidant and Flavor Compionents of Zingiber mioga Rosc

Full Text Available

2005-12-01

180

Effectiveness of Selective Peripheral Denervation for the Treatment of Spasmodic Torticollis

Full Text Available

2007-06-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

181

Effect of processing route on the composition and properties of hemp fibre

Full Text Available

2005-11-01

182

Effect of chelate rigidity on in vivo radioimmunoconjugate distribution

Full Text Available

183

Effect of Spices on the Growth of Pathogenic Bacteria

Short note.

1991-01-01

184

Effect of Spices on hepatic microsomal enzyme function in mice

Full Text Available

1997-08-01

185

Effect of Garlic on the Digestion of Beef Protein during Storage

Full Text Available

1984-06-01

186

Effect of Electromagnetic Fields on Growth of Human Cell Lines

Full Text Available

1991-10-01

187

Distribution of Photovoltaic Energy Including Topography Effect

Full Text Available

2001-10-01

188

Development of a Cost Effective Radio Communication System for UAS

Full Text Available

2011-04-01

189

Clinical effectiveness of antidepressants and antipsychotics in chronic benign pain.

Full Text Available

2008-06-01

190

Antioxidative Effects of Chitosan Meat Sausage

PMID:1354044

1992-01-01

191

Antioxidative Effect of Ethanol Extract for 5 Kinds of Spice

Full Text Available

2001-06-01

192

An Effective Grid Resource Management Model Based on Cloud Computing Platform

Full Text Available

2004-11-01

193

An Aplication Effect of UV-Absorbent on The Indigo Dyed Products

Not Available

2011-02-01

194

14 MeV neutron irradiation effects on window materials

Full Text Available

1999-08-01

195

The effects of organosulfur compounds upon the storage stability of Jet A fuel

No abstract prepared

1998-01-01

196

The Effects of Flame Retardant Combinations in PVC ...

This study examined the effect of sulfur-containing compounds on the storage stability of Jet A

1981-01-01

197

The Effect of the Temperature to Which the Material is Heated ...

... Title : The Effects of Flame Retardant Combinations in PVC-Epoxidised Natural Rubber Miscible Blends: Antimony Trioxide in Combination with ...

1989-03-01

198

Heavy Metals Effect on Animal Cells

... The Effect of the Temperature to Which the Material is Heated on the Process of Formation of Intermetallic Compounds in Magnetic Pulse Welding,. ...

1980-09-01

199

Effects of Pentobarbital Anesthesia on Survival, 'Escherichia ...

Studies of the Superheavy-metal Effect as a Stress-factor on Protein Biosynthesis and Cytoskeleton Integrity in Animal Cells

200

Effect of dietary constituents on the absorption of lead in the human

... Title : Effects of Pentobarbital Anesthesia on Survival, 'Escherichia coli' Clearance, Glucose and Leukocyte Concentration in Dogs Subjected to ...

1978-08-28

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

201

Effect of Yttrium on the Microstructure of Titanium Alloys,

... biological effects body burden diet intestinal absorption lead lead 203 man

1983-03-01

202

EFFECTS OF SHIELDING ON PROPERTIES OF EDDY ...

... Title : Effect of Yttrium on the Microstructure of Titanium Alloys,. ... The yttrium was added in the melting stage as an oxide or in the elemental form. ...

203

Diaphragm Rupture Effects on an Expanding Flow in a Tube.

... Accession Number : ADD323869. Title : EFFECTS OF SHIELDING ON PROPERTIES OF EDDY CURRENT PROBES WITH FERRITE CUP CORES. ...

1986-08-01

204

Coherency Effects on Retinal Neural Processes (ERG) of ...

... The fundamental problem of diaphragm rupture was studied experimentally to determine the effects on an expanding flow in an evacuated tube. ...

1972-08-01

205

Learning Effect and Standardization Effect in NPP's Construction

... Accession Number : ADA111683. Title : Coherency Effects on Retinal Neural Processes (ERG) of Pseudemys. Descriptive ...

1981-12-01

206

Effective medium theory of the one-dimensional resonance phononic crystal

This paper describes the learning effect and standardization effect in the nuclear power construction, analyses their influence degree on nuclear power economics. Furthermore, the paper provides the ideas on how to improve the economics of nuclear power through implementing the learning effect and standardization effect. The paper also concludes that the learning rate in China is better than the average value in the world by analysis actual example. (authors)

2009-09-01

207

Physical mechanism in the free-electron laser

A general theoretical scheme to describe the effective modulus and mass density for acoustic metamaterials is presented. For such a purpose, an effective medium theory of a one-dimensional acoustic waveguide containing subwavelength-sized Helmholtz resonators is formulated. It is shown that, when the wavelength is much larger than the periodic length and the size of the resonators, the whole composite structure can be treated as an effective homogeneous medium in accounting for its acoustic properties. It is also shown that the acoustic characteristics, such as the effective modulus and the effective mass density, can be determined precisely from the transmission and the reflection data. The calculated effective modulus and effective mass density confirm that this structure behaves as a homogeneous metamaterial with a negative ...

2008-02-06

208

Ionising radiation. Part 2

In this paper some physical mechanisms are described, which determine some new free-electron laser configurations. These mechanisms comprise some physical effects of the radiant emission of an electron beam at the interaction with the medium it is crossing. They are based on the Cherenkov effect, Smith-Purcell effect, optical klystron, Rumakhov effect and limited interaction effect. (Author).

1992-09-21

209

Effects of gamma irradiation on physiological effectiveness of Korean medicinal herbs

A brief tutorial on the health effects of ionising radiation is presented. The distinction between somatic and genetic health effects is explained. The two types of somatic health effects, i.e., acute and chronic effects, are discussed, as well as the concepts of ''deterministic'' and ''stochastic'' (also called ''probabilistic'') health effects. The possibility of cancer caused by DNA damage is discussed. The document ends with the definition of some key radiation terms.

2000-11-01

210

The effects of exercise and stress on the survival and maturation of adult-generated granule cells

Effects of gamma irradiation on the physiological effectiveness of Korean medicinal herbs were investigated. The physiological effectiveness including antioxidant and anticomplement function, nitrite scavenging and electron donating ability of Korean medicinal herbs by gamma irradiation at 10 kGy did not differ from that of the nonirradiated control.

1999-03-01

211

TJ-41 Induces Apoptosis and Potentiates the Apoptotic Effects of 5-FU in Breast Cancer Cell Lines

Stress strongly inhibits proliferation of granule cell precursors in the dentate gyrus, while voluntary running has the opposite effect. Few studies, however, have examined the possible effects...Full Text Available

2009-10-01

212

Mouse model predicts effects of smoking and varenicline on event-related potentials in humans

Recent studies suggest that TJ-41, a herbal drug, possesses chemotherapeutic effects. Accordingly, this study was undertaken to investigate the anticarcinogenic effects of TJ-41 on human breast cancer...Full Text Available

2009-01-01

213

Memory effect in air in the presence of vacuum breakdown mechanism

Background:Nicotine alters auditory event-related potentials (ERPs) in rodents and humans and is an effective treatment for smoking cessation. Less is known about the effects of...Full Text Available

2010-06-01

214

Health effects of urea formaldehyde foam insulation: evidence of causation.

Investigation of memory effects in air at 0.7 mbar pressure in the presence of vacuum electrical breakdown mechanism has been performed in this paper. The memory effect has been followed using the time delay method.

2008-07-01

215

Epidemiological survey of the effects of low level radiation dose: a comparative assessment

Studies of health effects of urea formaldehyde foam insulation (UFFI) were critically reviewed by means of accepted rules for evidence of causation. Three categories of health effects were examined:...Full Text Available

1986-04-01

216

Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials

This volume presents the collations tables of a six volume comparative epidemiological survey of the effects of low level radiation dose. Data are collated for the effects observed in the following irradiated groups:- Preconception irradiation, intra-uterine irradiation, childhood irradiation, adult irradiation. (UK).

1993-10-01

217

Cost-Effectiveness of an Opportunistic Screening Programme and Brief Intervention for Excessive Alcohol Use in Primary Care

Objectives To assess the effectiveness of calcium supplementation for improving bone mineral density in healthy children and to determine if any effect is modified by other factors and...Full Text Available

2006-10-14

218

Cost-Effectiveness Analysis of Proposed Effluent Limitations Guidelines and Standards for the Metal Products and Machinery Industry (Phase 1).

BackgroundEffective prevention of excessive alcohol use has the potential to reduce the public burden of disease considerably. We investigated the cost-effectiveness of Screening...Full Text Available

219

Beneficial Effect of a Short-Acting NO Donor for the Prevention of Neointimal Hyperplasia

This cost-effectiveness analysis supports the proposed effluent limitations guidelines and standards for the Metal Products and Machinery Industry (MP and M) Phase I Industry. The report assesses the cost-effectiveness of five regulatory options for indir...

1995-01-01

220

Assessing the effectiveness and cost effectiveness of adaptive e-Learning to improve dietary behaviour: protocol for a systematic review

Nitric oxide (NO)-based therapies effectively inhibit neointimal hyperplasia in animal models of arterial injury and bypass grafting, but are not available clinically. We created a simple, effective,...Full Text Available

2008-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

221

Adding effect sizes to a systematic review on interventions for promoting physical activity among European teenagers

BackgroundThe composition of habitual diets is associated with adverse or protective effects on aspects of health. Consequently, UK public health policy strongly advocates dietary...Full Text Available

222

New concepts in risk assessment for patients with radiological treatment

This commentary adds effect sizes to the recently published systematic review by De Meester and colleagues and provides a more detailed insight into the effectiveness of interventions to promote physical...Full Text Available

223

CT colonography and cost-effectiveness

In radiation risk assessment it must be differentiated between somatic and genetic effect on the one hand as well as between stochastic and non-stochastic effect on the other. According to definitions of the ICRP report 26 the limit for the dose equivalent of all tissues prevents non-stochastic radiation effects. With stochastic radiation effects probably exist no threshold doses; therefore the ALARA principle must be applied concerning radiation protection. The individual risk by stochastic radiation effects in its linear, linear-quadratic and quadratic extrapolations, respectively, is discussed in detail. The effective stochastic dose equivalent (H/sub eff/) as well as collective dose and collective damage are outlined.

1986-01-01

224

VIGILANCE, PREDATION RISK, AND THE ALLEE EFFECT IN DESERT BIGHORN SHEEP

CT colonography (CTC) is increasingly advocated as an effective initial screening tool for colorectal cancer. Nowadays, policy-makers are increasingly interested in cost-effectiveness issues. A number of studies assessing the cost-effectiveness of CTC have been published to date. The majority of findings indicate that CTC is probably not cost-effective when colonoscopy is available, but this conclusion is sensitive to a number of key parameters. This review discusses the findings of these studies, and considers those factors which most influence final conclusions, notably intervention costs, compliance rates, effectiveness of colonoscopy, and the assumed prevalence and natural history of diminutive advanced polyps. (orig.)

2008-11-15

225

Toxicological properties of lead.

... 2004)068[0519:VPRATA]2.0.CO;2 VIGILANCE, PREDATION RISK, AND THE ALLEE EFFECT IN DESERT ... revealed that predation risk (as es...

226

Technology Improvement Pathways to Cost-Effective Vehicle Electrification: Preprint

The pathological effects of lead on the renal, nervous, reproductive, endocrine, and immune systems have been reviewed. Emphasis is placed on reported subclinical effects due to chronic, low-level lead...Full Text Available

1977-08-01

227

THE BALDWIN EFFECT AND GENETIC ASSIMILATION: REVISITING TWO MECHANISMS OF EVOLUTIONARY CHANGE MEDIATED BY PHENOTYPIC ...

This paper evaluates several approaches aimed at making plug-in electric vehicles (EV) and plug-in hybrid electric vehicles (PHEVs) cost-effective.

2010-02-01

228

Strong-interaction effect measurements in sigma hyperonic atoms of W and Pb

... 1111/j.1558-5646.2007.00203.x THE BALDWIN EFFECT AND GENETIC ASSIMILATION: REVISITING TWO MECHANISMS OF ... to phenotypic plast...

229

Size Effects in Impact Damage of Composite Sandwich Panels Alan ...

Strong-interaction effects have been observed in the x-ray spectra of atoms formed with [Sigma][sup [minus

1993-03-01

230

Saturation effects at LHC energies

Wade. Jackson. - Army. VTD at NASA. Langley. ABSTRACT. Panel size has a large effect on the impact response and resultant damage level of honeycomb sandwich ...

231

Possible health effects of working with VDUs.

Within the framework of a modified Balitsky-Kovchegov equation, we calculated and provide estimates of non-linear saturation effects expected in the LHC range of energies.

2005-01-01

232

Mechanism of viscosity effect on magnetic island rotation

A summary of the effects presented here is given in the table. The designation "factor present" implies that there is knowledge (from human or animal studies, or both) of a specific factor(s) present...Full Text Available

1989-04-01

233

Influence of nebivolol on anticonvulsant effect of lamotrigine

It is shown that plasma viscosity does not influence the magnetic island rotation directly. Nevertheless, it leads to nonstationarity of the plasma velocity. This nonstationarity is the reason of the viscosity effect on island rotation. (author)

2000-04-01

234

Objective:The present study describes the effect of nebivolol (NBV) either alone or in combination with lamotrigine (LTG) using increasing current electroshock seizures...Full Text Available

2009-02-01

235

Human factors

Flame Retardant Effects in PVC-Epoxidised Natural Rubber ...

This is a presentation on Human Factors in reactor operations. It discusses issues that deal with power plant operations, training and design, operational effectiveness and safety, supporting people to achieve effective and error free performance.

2002-07-01

236

Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects, and ...

... Title : Flame Retardant Effects in PVC-Epoxidised Natural Rubber Miscible Blends: Halogen and Non-Halogen Based Additives,. Corporate Author : ...

1989-03-01

237

Efficacy and adverse effects of intravenous lignocaine therapy in fibromyalgia syndrome

... Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects, and Genomic InstabilityMary Helen Barcellos-Hoff1a ... ...

238

Effects of phenoxybenzamine on bladder neck opening1

BackgroundTo investigate the effects of intravenous lignocaine infusions (IV lignocaine) in fibromyalgia.MethodsProspective study...Full Text Available

239

Effects of Yttrium Microalloying on the Epitaxial Grain Growth ...

A study of the effects of the action of phenoxybenzamine on bladder neck opening during micturition is reported. Twenty patients with symptoms of prostatism but minimal prostatic enlargement were studied....Full Text Available

1980-05-01

240

Effect of ginger on gastric motility and symptoms of functional dyspepsia

... Accession Number : ADA137272. Title : Effects of Yttrium Microalloying on the Epitaxial Grain Growth in Ti-6Al-4V Weld Fusion Zones. ...

1983-10-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

241

Effect of gamma radiation and bag packaging materials on the development of Dermestes maculatus De Geer (Coleoptera: Dermestidae) in sword fish

AIM: To evaluate the effects of ginger on gastric motility and emptying, abdominal symptoms, and hormones that influence motility in dyspepsia.METHODS: Eleven patients with functional dyspepsia...Full Text Available

2011-01-07

242

Effect of Roller Profile on Cylindrical Roller Bearing ... - GLTRS - NASA

... EFFECT OF GAMMA RADIATION AND BAG PACKAGING MATERIALS ON

1998-06-01

243

Effect of Registration on Cyclical Kinematic Data

J.V. Poplawski and Associates, Bethlehem, Pennsylvania. Effect of Roller Profile on Cylindrical. Roller Bearing Life Prediction. NASA/TM2000-210368 ...

244

Effect of Deforestation on a Southwest Ghana Dung Beetle Assemblage (Coleoptera: Scarabaeidae) at the Periphery of ...

Given growing interest in Functional Data Analysis (FDA) as a useful method for analyzing human movement data, it is critical to understand the effects of standard FDA procedures, including...Full Text Available

2010-08-26

245

Diagnostics of Radionuclides Effects Results

... 1081:EODOAS]2.0.CO;2 Effect of Deforestation on a Southwest Ghana Dung Beetle Assemblage (Coleoptera: ... The survey provided a...

246

Cooperative Effects on Transient Spectral Hole Burning

Development of New Methods and Means of Assessing of Consequences of Radionuclide and Heavy Metal Salt Effect, Criteria of Forecasting Physiological State and Productivity of the Farm Animals under Conditions of Ecological Pollution of Environment

247

Cooperative Charging Effects of Fibers From Electrospinning ...

... of Dist SpeA tI/ __LLL5' Page 5. 3 the coherent effects on the spontaneous radiation, we calculate the pump- field-induced ...

1992-06-01

248

Contamination Effects of Satellite Material Outgassing ...

... In the Proceedings of INTC 2003, we studied charging effects on target coverage during electrospinning (16). ... of Fibers from Electrospinning of ...

2005-01-05

249

Camouflage Patterns-Effects of Size and Color.

... A detailed analysis of QCM errors is ... Surface Effects of Satellite Outgassing Products." AIAA Journal ... 9. Rauschenbach, H. S. Solar Cell Array Design ...

1990-12-01

250

Biological radiation effects

... CAMOUFLAGE PATTERS- EFFECTS OFSIZE AND COL0R.-(U I'. * ... Camouflage, survei.Ilance, countersurveiliance, vi~sion, color ...

1979-07-01

251

Atmospheric Scintillation Effects on Electromagnetic Weapons

The stages of processes leading to radiation damage are studied, as well as, the direct and indirect mechanics of its production. The radiation effects on nucleic acid and protein macro moleculas are treated. The physical and chemical factors that modify radiosensibility are analysed, in particular the oxygen effects, the sensibilization by analogues of nitrogen bases, post-effects, chemical protection and inherent cell factors. Consideration is given to restoration processes by excision of injured fragments, the bloching of the excision restoration processes, the restoration of lesions caused by ionizing radiations and to the restoration by genetic recombination. Referring to somatic effects of radiation, the early ones and the acute syndrome of radiation are discussed. The difference of radiosensibility observed in mammalian cells and main observable alterations in tissues and organs are commented. ...

1976-01-01

252

An Intrinsic Baldwin Effect in the H Beta Broad Emission Line in the Spectrum of NGC 5548

... 4. TITLE AND SUBTITLE Atmospheric Scintillation Effects on Electromagnetic Weapons 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. ...

2008-12-01

253

A framework for evolutionary systems biology

We investigate the possibility of an intrinsic Baldwin effect (i.e., nonlinear emission-line

2003-01-01

254

http://jr.chemwatch.net/ausmud/msds.exe?mode=SAP&cwno=4902-93&c

BackgroundMany difficult problems in evolutionary genomics are related to mutations that have weak effects on fitness, as the consequences of mutations with large effects are often...Full Text Available

255

[The effect of ascorbic acid on a new urine test strip for the detection of erythrocytes].

CHRONIC HEALTH EFFECTS

256

[Effects of anaerobic and aerobic exercises in athletes on the variation of the parameters of oxygen transport systems during different seasons of the year].

PMID:7177024

1982-11-01

257

Water-Soluble Prodrug of Anti-Microtubule Agent Plinabulin: Effective Strategy with Click Chemistry.

PMID:18472586

258

Therapeutic effects of topical application of ozone on acute cutaneous wound healing.

PMID:21956869

2011-09-29

259

Therapeutic Effects of Bergenin and Acetylbergenin on Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Full Text Available

2009-06-01

260

The intrinsic nature of the Baldwin effect

Full Text Available

2000-12-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

261

The effect of Allium sativum L. extract on hepatic function in rats with $CCl_4$-induced (hepatic) injury

The relationship between the fluxes of the two strongest UV emission lines and flux in the continuum

1992-01-01

262

The anti-inflammatory effects of ulinastatin in trauma patients with hemorrhagic shock.

Full Text Available

2010-05-01

263

The Essentials of Mathematics, Grades 7-12 Effective Curriculum, Instruction, and Assessment

Full Text Available

2010-01-01

264

The Enzymatic Regulatory Effects of Laninaria japonica Fucoidan Extract in Hepatotoxicity

The Essentials of Mathematics, Grades 7-12

2006-01-01

265

The Effects of Integrated Environmental Experience Program on Environmental Attitude of Elementary Schoolers

Full Text Available

2006-12-01

266

The Effects of Additions of In & Sb on Resistivity & Sensitivity in Tin Oxide Gas Sensors

Full Text Available

2010-12-01

267

The Effect of Self-esteem, Academic Achievement and Family Functioning of Adolescents on Hope

Full Text Available

1992-11-01

268

The Effect of Radiated Electromagnetic Wave by Digital Modulation Signals on the Electronic Devices

Full Text Available

2001-01-01

269

The Effect of Garlic and Medicinal Plants Extracts on the Liver Function and Lipid Metabolism of Rats Administered with Alcohol

Full Text Available

2011-02-01

270

The Effect of Additional Mobilization with Conservative Physical Therapy in Patients with Frozen Shoulder on ROM and Subjective Pain Scale

Full Text Available

2009-05-01

271

The Damage of Microcontroller Devices due to Coupling Effects under High Power Electromagnetic Wave by Magnetron

Full Text Available

2009-11-01

272

The Acute Effect of Trimetazidine on the High Frequency Fatigue in the Isolated Rat Diaphragm Muscle

Full Text Available

2008-12-01

273

Temperature and vital effect controls on Bamboo coral (Isididae) isotopegeochemistry: A test of the "lines method"

Full Text Available

2004-06-01

274

THE EFFECTS OF ONE MEGACYCLE ULTRASONIC ...

Abstract not provided

2011-03-01

275

THE EFFECT OF FIBRE MISALIGNMENT ON THE ...

... ULTRASONIC VIBRATION TO PORTLAND CEMENT-WATER PASTE REDUCES THE ULTIMATE COMPRESSIVE STRENGTH OF MORTARS ...

1959-09-09

276

Symposium (International) (4th) on DETONATION Held at ...

... and testing of unidirectional composites, there are serious doubts about the possibility of obtaining a true ultimate compressive strength for this kind ...

277

Surface radiation effects on natural convection cooling of discrete heat source in an open-top cavity

... 442 RHF Stresau CONFINEMENT EFFECTS IN EXPLODING BRIDGEWIRE INITIATION OF DETONATION ..... ...

1965-10-15

278

Statistical cut-off criterion

Short communication.

1995-08-14

279

Some comments on BEIR III

... radiation effects human populations low dose irradiation neoplasms radiation

1980-01-01

280

SAXS studies of the injection molding effects on the nanostructure of polyesters. I. Polybutylene terephthalate (Pbt)

... organizations irradiation radiation doses radiation effects RADIATIONS.

1982-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

281

Regrinding Effect of Flat End-Mill Tool for Recycling of Tungsten Carbide (WC-Co) Material

No abstract prepared.

2004-07-01

282

Reaction-diffusion effects on species mixing rates in turbulent premixed methane-air combustion

Full Text Available

2008-12-01

283

Radioprotective effect of fish products

No abstract prepared.

2009-06-01

284

Radiological equipment for emergencies

New fish cans were prepared in the Institute of Fish Industry, Burgas (BG), containing pectin and additives. A biological experimental study was conducted to investigate the decontaminating effect of the new products. The results demonstrated no decontaminating effect in relation to radiocesium and radiostrontium. A pronounced prophylactic effect was observed in case of external irradiation, judged by endogenous spleen colonies. (author).

1993-12-02

285

Radiative Heat Transfer Augmentation in Gas-Fired Radiant Tube Burners by Porous Inserts: Effect of Insert Geometry

A brief guide to training and equipment needed to effectively manage victims of radiation accidents. (DT)

1985-01-01

286

Radiation technology of wood-plastic composite materials

Not Available

1993-07-01

287

Radiation effects on the shoot tip culture of chrysanthemum

... radiation effects RADIATIONS. WOOD-PLASTIC COMPOSITES.

1981-10-02

288

RESEARCH PAPERS : AN EFFECT OF THE REDUCTION OF TOXICITY USING BICARBONATE CATALYST ON WASTEWATER

Japanese (Mar 1974). Japan Mabuchi, Toshio Kuwada, Hikaru . Kagawa Univ.,

289

Protective effects of Opuntia ficus-indica on Glutathione and Antioxidative Enzyme

Full Text Available

2004-06-01

290

Protective and therapeutic effects of swimming exercise training on diabetic peripheral neuropathy of streptozotocin-induced diabetic rats.

Full Text Available

2003-12-01

291

Protective Effects of Acetylbergenin against Carbon Tetrachloride Induced Hepatotoxicity in Rats

PMID:19169052

2008-11-01

292

Protective Effect of Some Medicinal Plants on tert-Butyl Hydroperoxide-Induced Oxidative Stress in Human Keratinocytes

Full Text Available

2001-04-01

293

Prevention of Alloxan-induced Diabetes by Se-Methylselenocysteine Pretreatment in Rats: The Effect on Antioxidant System in Pancreas

Full Text Available

2008-12-01

294

Potentiation of Antitumor Effect of Radiotherapy by Recombinant Tumor Necrosis Factor-$\\alpha$

Full Text Available

2009-06-01

295

Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures.

Full Text Available

1998-09-01

296

Peristaltic flow of a couple stress fluid under the effect of induced magnetic field in an asymmetric channel

PMID:17276750

2007-02-15

297

Not Available

2011-01-01

298

PRODUCT NAME BARITE

POTENTIATION BY PENTOBARBITAL OF THE PROTECTIVE ...

the low levels of crystalline silica in this product, chronic health effects are not anticipated with normal

299

On the effects of boron and phosphorus primary impurities in p-type silicon material for solar cells

... Accession Number : AD0268549. Title : POTENTIATION BY PENTOBARBITAL OF THE PROTECTIVE EFFECT OF AET AGAINST GAMMA RAYS. ...

1961-10-01

300

On the Relationship between Typhoon Intensity and Formation Region: Effect of Developing and Decaying ENSO

Not Available

1979-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

New physics effects on Higgs production at #gamma##gamma# colliders

Full Text Available

2008-02-01

302

Magnetic field effect on fluid flow characteristics in a pipe for laminar flow

We study heavy physics effects on the Higgs production in #gamma##gamma# fusion using the effective Lagrangian approach. We find that the effects coming from new physics may enhance the standard model predictions for the number of events expected in the final states b-barb, WW, and ZZ up to one order of magnitude, whereas the corresponding number of events for the final state t-bart may be enhanced up to two orders of magnitude.

1996-02-20

303

Linear Analysis of the In-Phase and Out-of-Phase Stability Behavior of a Natural Circulation Reactor: Upscaling Effects

Full Text Available

2011-02-01

304

Influences of B Number Effect on the Burning Rate of Solid Fuel in Single Port Hybrid Rocket

Not Available

2007-02-01

305

Inertial Dynamic Effect on the Rates of Diffusion-Controlled Ligand-Receptor Reactions

Full Text Available

2008-03-01

306

Individual or combined effects of enalapril and verapamil on chronic cyclosporine nephrotoxicity in rats.

Full Text Available

2011-08-01

307

In-vivo study on the harmful effect of the extremely low frequency unipolar pulsating magnetic field in mice.

Full Text Available

1999-12-01

308

Implantation-plasma treatment of martensitic steel and titanium alloy

Full Text Available

1997-04-01

309

Impairing Effects of Acute Glucose Overload on Calcium Homeostasis in Vascular Endothelial Cells

One of the effective methods of deep modification of the surface of steels and alloys is the combination of ion implantation and plasma nitriding. In this work, the long-range effect is demonstrated in the case of combination of the effect of high- and low-energy ions of nitrogen on a martensitic steel for each ion implantation is usually not effective, and a titanium alloy used widely in industry.

2001-07-01

310

Ignition and Flame Propagation of Solid Fuel with Radiation Effect in a Cylindrical Combustor

Full Text Available

1998-12-01

311

Flood Routing Analysis Considering the Effects of Dams in Han River

Full Text Available

2001-02-01

312

Ferromagnetism in Mn-doped GaAs layers: Effects of laser annealing

Full Text Available

2005-09-01

313

Epoxidised natural rubber/silica hybrid nanocomposites by sol-gel technique: Effect of reactants on the structure and the properties

The properties of Mn-doped GaAs layers grown by laser deposition were investigated with measurements of Hall effect and magneto-optical Kerr effect (MOKE). The electrical and magnetic parameters of the layers were defined by growth temperature and quantity of sputtered Mn. It was shown that room-temperature ferromagnetism is revealed by MOKE and, after ruby laser 25 ns pulse annealing, by Hall effect measurements.

2006-05-15

314

Environmental Effects on Oil Pipelines

Not Available

2005-01-01

315

Enhancement of Whitening Effects of Lithospermum erythrorhizon Extracts by Ultra High Pressure

Determination of the Ecology Factor for the Magistral Oil Pipelines, Working in Difficult Hilly and Geology Conditions

316

Enhancement of Antioxidant Activities and Whitening Effect of Acer mono Sap Through Nano Encapsulation Processes

Full Text Available

2011-04-01

317

Effects of thyroxine on hyperkalemia and renal cortical Na+, K+ - ATPase activity induced by cyclosporin A.

Full Text Available

2011-06-01

318

Effects of the Feeding Mixture of Mushrooms and Vegetables Oils on the Lipid Component and Fatty Acid Composition of Liver in Rats

Full Text Available

2002-10-01

319

Effects of the Excitation Level on the Dynamic Characteristics of Electrical Cabinets of Nuclear Power Plants

Full Text Available

1994-10-01

320

Effects of season and body condition score on lipid metabolism and oxidative status of periparturient dairy cows

Full Text Available

2010-06-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

Effects of positive and negative stretching on the structure and properties of polyacrylonitrile fibers in the pre-oxidation process

No abstract prepared.

2005-07-01

322

Effects of extracts of medicinal plants in the parasitaemia of Trypanosoma cruzi and in the biodistribution of the technetium-{sup 99m}

Full Text Available

2011-06-01

323

Effects of Treatment According to Tattoo Color, Site and Duration with the Q-Switched Alexandrite Laser

No abstract prepared.

2008-10-15

324

Effects of Traditional Salt on the Quality Characteristics and Growth of Microorganisms from Kimchi

Full Text Available

325

Effects of Single or Mixed Supplements of Plant Extract, Fermented Medicinal Plants and Lactobacillus on Growth Performance in Broilers

Full Text Available

2010-02-01

326

Effects of Simulated Acid Rain on Growth, Pigments and Leaf Surface Morphology of the Seedlings of Amaranthus tricolor L.

Full Text Available

2007-09-01

327

Effects of Restricted Feeding during Growing Period on Laying Performance and Egg Quality in Layers

Full Text Available

1994-08-01

328

Effects of Polymerization and Spinning Conditions on Mechanical Properties of PAN Precursor Fibers

Full Text Available

2008-03-01

329

Effects of Oxygen Enrichment on the Structure of Premixed Methane/Fluorinated Compound Flames

Full Text Available

2010-09-01

330

Effects of Nitric Oxide Donor Supplementation on Copper Deficient Embryos and Nitric Oxide-Mediated Downstream Signaling

Full Text Available

2011-08-01

331

Effects of Medicinal Plants on the Quality and Physiological Functionalities of Traditional Ginseng Wine

Full Text Available

2008-12-01

332

Effects of MeV ion irradiation on crystallization of amorphous Ge films

Full Text Available

2007-06-01

333

Effects of Liming on Uptake to Crops of Heavy Metals in Soils amended with Industrial Sewage Sludge

Short communication.

1995-12-31

334

Effects of Horseback Riding Simulation Machine Training on Gross Motor Function for the Children with Cerebral Palsy

Full Text Available

2002-03-01

335

Effects of Gas Flow Ratio on the Properties of Tool Steel Treated by a Direct Current Flasma Nitriding Process

Full Text Available

2010-05-01

336

Effects of Fish Oil and Some Seed Oils on Lipid Composition of Serum in Rats

Full Text Available

2005-10-01

337

Effects of Fish Oil and Some Seed Oils on Fatty Acid Compositions of Liver and Brain Tissue in Rats

Full Text Available

1991-08-01

338

Effects of Exposure Period on the Developmental Toxicity of 2-Bromopropane in Sprague-Dawley Rats

Full Text Available

1991-10-01

339

Effects of Elevated Atmospheric $CO_2$ Concentrations on Soil Microorganisms

Full Text Available

2008-12-01

340

Effects of Electric Current Stimuli and High-Voltage Electric Field Treatments on Brown Rice Germination

Full Text Available

2004-12-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

Effects of Dissolved Oxygen on Fungal Morphology and Process Rheology During Fed-Batch Processing of Ganoderma lucidum

Full Text Available

2010-04-01

342

Effects of Different Dietary Oils on Hepatic Mitochnodial Lipid Composition and Adenine Nucleotide Translocase Activity in Rat

Full Text Available

2010-04-01

343

Effects of Dietary Korean Mistletoe on Performance and Blood Characteristics in Broilers

Full Text Available

1993-07-01

344

Effects of Dietary ?-Fatty Acids on the Fatty Acid Composition of Pork and Plasma Lipids in Swine

Full Text Available

2007-06-01

345

Effects of Dehydration Methods and Storage Conditions on Germinability of Pelleted Carrot Seeds

Full Text Available

2007-05-01

346

Effects of Coulomb and kaon nuclear potentials on soft K{sup +} production from nuclei

Full Text Available

2009-04-01

347

Effects of Concrete and Wood Building Environments on Pregnant Dams and Embryo-Fetal Development in Rats

No abstract prepared.

2002-03-01

348

Effects of Callophyllis japonica powder on carbon tetrachloride-induced liver injury in rats

Full Text Available

2009-12-01

349

Effects of Calcium Supplementations on Mineral Metabolism during Pregnancy with Calcium-Deficient Young Adult Rats

Full Text Available

2005-09-01

350

Effects of Ca Supplementation on Mineral Metabolism during Pregnancy and Lactation of Calcium-Deficient Young Adult Rats

Full Text Available

2003-06-01

351

Effective dose equivalent in nuclear medicine investigations

Full Text Available

2004-07-01

352

Effect on the Quality Characteristics of Korean Traditional Wines with the Addition of Rosemary (Rosmarinus officinalis L.)

... radiation hazards hazards health hazards MEDICINE. SOMATICALLY

1984-05-07

353

Effect of the medicinal plant Echinacea purpurea on the bioavailability of the radiopharmaceutical {sup 99M}TC-sodium pertechnetate

Full Text Available

2006-12-01

354

Effect of the Toluene Administration on the Liver Damage in Rats Fed Low or Standard Protein Diet

No abstract prepared.

2008-10-15

355

Effect of the Mixing Extraction of Perilla Seed and Peanut on Physicochemical Characteristics and Oxidative Stability of Perilla Oil

Full Text Available

1996-12-01

356

Effect of simulated Acid Rain on the Morphology and Enzyme of Perilla frutescens var. japonica Hara

Full Text Available

1999-12-01

357

Effect of outside air ventilation rate on volatile organic compound concentrations in a call center

Full Text Available

1996-04-01

358

Effect of nitric oxide on endoplasmic reticulum calcium homeostasis, protein synthesis and energy metabolism

No abstract prepared.

2003-04-01

359

Effect of equal channel angular pressing on the deformation behaviour of magnesium alloy AZ31 under uniaxial compression

ATPase, endoplasmic reticulum, calcium, ischaemia

2000-01-01

360

Effect of Zinc-Enriched Yeast Supplementation on Serum Zinc and Testosterone Concentrations in Ethanol Feeding Rats

No abstract prepared.

2006-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Effect of Weight and Apllied Force on the Friction Coefficient of the Spunlace Nonwoven Fabrics

Full Text Available

2008-07-01

362

Effect of TIBA, PCIB and phloroglucinol on somatic embryo maturation and germination in Japanese larch (Larix leptolepis)

Full Text Available

2010-04-01

363

Effect of Supplementation with Docosahexaenoic Acid from Gestation to Adulthood on Spatial Learning Performance in Rat

Full Text Available

2009-09-01

364

Effect of Ondansetron Alone and Combination of Naltrexone and Ondansetron on Alcohol Intake in C57BL/6 Mice

Full Text Available

2007-10-01

365

Effect of Nitrite and Nitrate as the Source of OH Radical in the O3/UV Process with or without Benzene

Full Text Available

2007-11-01

366

Effect of Milling Medium Materials on Mechanical Alloying of Mo-65.8at%Si Powder Mixture

Full Text Available

2011-08-01

367

Effect of Low Night Temperature on Reproductive Organ Development in Relation to Pollen Viability of Bell Pepper

Full Text Available

1997-09-01

368

Effect of Lotus (Nelumbo nucifera) Leaf Powder on the Quality Characteristics of Chicken Patties in Refrigerated Storage

Full Text Available

2009-05-01

369

Effect of KI on improving copper corrosion inhibition efficiency of benzotriazole in sulfuric acid electrolytes

Full Text Available

2011-02-01

370

Effect of Inorganic Fillers on the Properties of Hydrated PAN Melt(I) -Rheological Properties of Hydrated PAN Melt-

A synergistic effect exists when benzotriazole (BTAH) and iodide ions are used together to prevent the corrosion of copper in sulfuric acid. The nature of this effect has been studied systematically by using electrochemical techniques and X-ray photoelectron spectroscopy. The synergistic effect is due largely to the formation of a film of Cu(IBTA) complex and is probably polymeric in nature. This new complex film greatly depresses copper dissolution.

1993-10-01

371

Effect of High Omega-3 Fish Intake on Lipid Peroxidation

Full Text Available

2000-10-01

372

Effect of Heat Treatment on CO2 Adsorption of Ammonized Graphite Nanofibers

Omega-3 Fatty Acids; Lipid Peroxidation

2011-05-31

373

Effect of Heat Treatment of Garlic Added Diet on the Blood of Spontaneously Hypertension Rat

Full Text Available

2010-03-01

374

Effect of Garlic and Medicinal Plants Composites on Antioxidant Activity and Lipid Levels of Liver in Hypercholesterolemic Rats

Full Text Available

1997-02-01

375

Effect of Extracelluar Matrix on Cell-Surface Interactions and Growth of Cardiomyocyte(HL-1)

Full Text Available

2009-12-01

376

Effect of Ethanol-pretreatment on the Liver Xanthine Oxidase Activity in Xylene-treated Rats

Full Text Available

2010-01-01

377

Effect of Dietary Supplementation of Acanthopanax senticosus and Eucommia ulmoides on Antioxidant Defense System in Laying Hens

Full Text Available

1998-08-01

378

Effect of Dietary Protein on the Changes of Lipoprotein Fractions in Carbon Tetrachloride-Treated Rats

Full Text Available

2010-03-01

379

Effect of Dietary Energy, Protein on Growth and Blood Composition of Cross Bred Chicks

Full Text Available

1993-04-01

380

Effect of Dietary Anti-oxidant Supplementation on Telomere Length and Egg Quality in Laying Hens

Full Text Available

2008-09-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

381

Effect of Di-(2-ethylhexyl)-phthalate on Sphingolipid Metabolic Enzymes in Rat Liver

Full Text Available

2008-09-01

382

Effect of Cyclohexanone Treatment on the Activities of Oxygen Free Radical Metabolizing Enzyme in the Liver Damaged Rats

Full Text Available

2011-09-01

383

Effect of Cyclohexane Treatment on the Liver Damage in CCl4-Pretreated Rats

Full Text Available

2002-06-01

384

Effect of Cyclohexane Treatment on Serum Level of Glutathione S-Transferase Activity in Liver Damaged Rats

Full Text Available

2003-06-01

385

Effect of Circadian Rhythms on the Xylene Metabolizing Enzyme Activities in Rats

Full Text Available

2003-06-01

386

Effect of Chitosan Solution on the Inhibition of Pseudomonas fluorescens Causing Bacterial Head Rot of Broccoli

Full Text Available

2001-06-01

387

Effect of Chemical Treatment of Teflon Powder on the Properties of Polyamide 66/Teflon Composites Prepared by Melt Mixing

Full Text Available

2010-06-01

388

Effect of Carbon Source Consumption Rate on Lincomycin Production from Streptomyces lincolnensis

Full Text Available

2011-06-01

389

Effect of COY(Cooking Oil and Yolk Mixture) on Control of Tetranychus urticae

Full Text Available

2004-06-01

390

Effect of Bubbles on Liquid Nitrogen Breakdown in Plane-Plane Electrode Geometry From 100-250 kPa

Full Text Available

2008-09-01

391

Effect of Bisphenol A Administration on Reproductive Toxicant of Dam and Sex Ratio of Pups in Pregnant Mice

Not Available

2011-06-01

392

Effect of Angiotensin-I Converting Enzyme Inhibitory from Hydrolysate of Soybean Protein Isolate

Full Text Available

2005-06-01

393

EFFECT OF SHIP ATTITUDE AND SHIP MOTION ON PRIMARY COOLANT SYSTEM FLOW RATES. Appendix A: DERIVATION OF EFFECT OF ANGULAR ACCELERATION ON DRIVING HEAD IN A NATURAL CIRCULATION REACTOR

Full Text Available

2010-01-01

394

EFFECT OF MICROSTRUCTURE ON THE STRENGTH ...

Analytical techniques for analyzing the effects of ship motion and attitude on the primary coolant system flow rates are presented. Design data for minimizing these effects are given. (C.J.G.)

1960-01-24

395

Conversion gain in a Josephson effect mixer

... THE STRENGTH, TOUGHNESS, AND STRESS-CORROSION CRACKING SUSCEPTIBILITY OF A METASTABLE BETA TITANIUM ALLOY (Ti-11. ...

1970-02-01

396

Contribution to the radiation preparation of wood-plastic materials. Pt. 7

United States Taur, Y. Claassen, JH Richards, PL Department of Physics,

397

Contribution to the radiation preparation of wood-plastic materials. Pt. 6

... odd nuclei organic compounds radiation effects radioisotopes synthesis

1974-01-01

398

Contribution to the radiation preparation of wood-plastic materials Pt. 3

... compounds polymers polyolefins polyvinyls radiation effects SYNTHESIS.

1974-01-01

399

Continuous Strategy Development for Effects-Based ...

... compounds plants radiation effects radioisotopes reaction kinetics trees

1974-01-01

400

Climate Change: The Role of Particles and Gases

... BAE Systems Advanced Information Technologies, Inc. APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. ...

2006-02-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

ScienceCinema

...global warming ...the effects of global warming ...also the ? that global warming ...

402

Capsaicin induced apoptosis and the enhanced anticancer effect of anticancer drugs in cancer cells

Calculation of some energetic parameters of astatine compounds

Full Text Available

2008-03-01

403

CRC handbook of biological effects of electromagnetic fields

... astatine complexes astatine compounds coulomb energy effective charge

404

Biophotonics and Bone Biology

This book presents the current knowledge about the effects of electromagnetic fields on living matter. The three-part format covers dielectric permittivity and electrical conductivity of biological materials; effects of direct current and low frequency fields; and effects of radio frequency (including microwave) fields. The parts are designed to be consulted independently or in sequence, depending upon the needs of the reader. Useful appendixes on measurement units and safety standards are also included.

1986-01-01

405

Antiproliferation Effects of Germinated-Korean Rough Rice Extract on Human Cancer Cells

One of the more-serious side effects of extended space flight is an accelerated bone loss

2004-01-01

406

Antiproliferation Effects of Ethanol and Water Extracts from Germinated Rough Rice

Full Text Available

2010-03-01

407

Antioxidative Activity and Nitrite Scavenging Effect of the Composites Containing Medicinal Plant Extracts

Full Text Available

2010-08-01

408

Antioxidant and Anticancer Effects of Agrimony (Agrimonia pilosa L.) and Chinese Lizardtail (Saururus chinensis Baill)

Full Text Available

2007-08-01

409

Antioxidant Effect of Oil Containing Cellulase-Treated Red Ginseng.

Full Text Available

2008-06-01

410

Antimutagenic effects of browning products reacted with polyphenol oxidase extracted from peach

Full Text Available

2008-03-01

411

Antimicrobial Effect of Medicinal Plants against Methicillin-Resistant Staphylococcus aureus (MRSA)

Full Text Available

1992-04-01

412

Antihyperglycemia Effect of Medicinal Plants Mixture in Streptozotocin-Induced Diabetic Rats

Full Text Available

2007-03-01

413

Antidiabetic Effects of Leaves Extracts of Psidium guajava L. and Lagerstroemia speciosa L. in STZ-induced Rats

Full Text Available

2008-12-01

414

Anti-Oxidative Effects of Ulva lactuca Extract Fractions Against CCl4 Toxification

Full Text Available

2009-01-01

415

Analysis of the Effect of Water Budget Elements on Flow Duration Characteristics using SWAT-Nak Dong

Full Text Available

2006-12-01

416

An analytical study of linear and non-linear double diffusive convection with Soret and Dufour effects in couple stress fluid

Full Text Available

2007-03-01

417

Ameliorating Effect of Capsaicin on Alterations in Lipid Metabolism during Mice Lung Carcinoma

Not Available

2007-09-01

418

Addition of electronic prescription transmission to computerized prescriber order entry: Effect on dispensing errors in community pharmacies.

Full Text Available

2009-02-01

419

APOPTOSIS INDUCER HAVING NEW INHIBITORY EFFECT ON INTRACELLULAR PARASITIC MICROORGANISM

PMID:21200064

2011-01-15

420

J-STORE (Japan)

Full Text Available

2006-11-10

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421

ADULT ACQUIRED TOLERANCE TO HOMOGRAFTS.

A study of the Baldwin effect in the IUE data set

... The effectiveness of immune suppression with both 6-mercaptopurine and methotrexate was insufficient to permit induction of a clinically useful ...

1967-07-31

422

A numerical analysis of reaction-diffusion effects on species mixing rates in turbulent premixed methane-air combustion

The paper investigates the controversial relation between the continuum luminosity and the C IV 1550 emission-line strength in the spectra of quasars, commonly referred to as the Baldwin effect, as a possible indicator of absolute luminosity. It is concluded that the Baldwin effect does represent a physical correlation between the continuum and the C IV 1550 equivalent width rather than a consequence of selection effects. In addition to the C IV results, a similar relation is found for the Lyman-alpha emission line. 38 refs.

1990-07-01

423

A Study of the Histological Effects of Garlic Extract in a Liver-damage Rat Model

No abstract prepared.

2009-05-01

424

A STUDY ON THE AIR SCREEN IN WATER 1. Experiments on the Air Screen Effects for Driving and Intercepting Fish School

Full Text Available

2010-08-01

425

A Numerical Study on a Circulation Control Foil using Coanda Effect

Full Text Available

1972-06-01

426

A Comparative Study About the Effect of Nonablative Laser and Thermal energy on Rabbit Knee Joint Capsular Properties

Full Text Available

2000-05-01

427

The importance of axial effects for borehole design of geothermal heat-pump systems

Full Text Available

2001-06-01

428

Numerical analysis of methane-air combustion considering radiation effect

This paper studies the effects of axial heat conduction in boreholes used in geothermal heat pump systems. The axial effects are examined by comparing the results obtained using the finite and infinite line source methods. Using various practical design problems, it is shown that axial effects are relatively important. Unsurprisingly, short boreholes and unbalanced yearly ground loads lead to stronger axial effects. In one example considered, it is shown that the borehole length is 15% shorter when axial conduction effects are considered. In another example dealing with underground water freezing, the amount of energy that has to be removed to freeze the ground is three times higher when axial effects are considered. (author)

2010-04-15

429

Numerical analysis of methane-air combustion considering radiation effect

Turbulent premixed methane-air combustion in a cylindrical chamber is numerically simulated considering radiation effect. Reaction rates are considered as minimum rates between Arrhenius rates and eddy break up rates. A five step reduced mechanism is used. Turbulent modeling is done via standard k-{epsilon} model imposed by empirical inlet boundary conditions. Source terms of energy equation consist of reaction rates and radiation effects. The discrete ordinate method (DOM) is employed to solve the radiative transfer equation (RTE) and the weighted sum of gray gas model (WSGGM) is imposed to consider radiation effect of non-gray gases. The results indicate that in the case of turbulent combusting flows, the effect of radiation of gases can affect the temperature and species concentrations. The numerical results obtained considering radiation effect are closer to the experimental ...

2008-12-15

430

Biological effects of electromagnetic radiation in the microwave range

Turbulent premixed methane-air combustion in a cylindrical chamber is numerically simulated considering radiation effect. Reaction rates are considered as minimum rates between Arrhenius rates and eddy break up rates. A five step reduced mechanism is used. Turbulent modeling is done via standard k-? model imposed by empirical inlet boundary conditions. Source terms of energy equation consist of reaction rates and radiation effects. The discrete ordinate method (DOM) is employed to solve the radiative transfer equation (RTE) and the weighted sum of gray gas model (WSGGM) is imposed to consider radiation effect of non-gray gases. The results indicate that in the case of turbulent combusting flows, the effect of radiation of gases can affect the temperature and species concentrations. The numerical results obtained considering radiation effect are closer to the experimental data than ...

2008-12-01

431

Afferent mechanisms of microwave-induced biological effects. Annual report, 1 June 1985-31 May 1986

The book examines current experimental and clinical knowledge concerning the biological and biophysical effects of electromagnetic radiation, particularly that in the microwave range. The biophysical bases of the interaction of electromagnetic radiation with matter are reviewed with emphasis on biological systems, and the effects of radiation on critical biological systems, including the nervous, reproductive, visual and blood-forming systems are compared. Data concerning the lethal effects of nonionizing radiation is presented and characteristics of the effects of electromagnetic radiation on the whole mammalian organisms are examined. Various reactions of the neuroendocrine system to electromagnetic radiation are described, with particular attention given to the adrenal system, and the combined effects of ionizing and microwave radiation in the flight environment are discussed. ...

1980-01-01

432

Effect of humidity in a mixture on combustion (Part 1). Effect on laminar burning velocity

Effects of 2450-MHz circularly polarized microwave irradiation on central nervous system functions were studied. Pulsed (microsecond, 500 pps) microwaves decreased high-affinity sodium-dependent choline uptake in the hippocampus and frontal cortex of the rat. The effect on hippocampal choline uptake was blocked by pretreatment with narcotic antagonists. Continuous-wave microwaves of the same power density decreased choline uptake in the frontal cortex only. Furthermore, it was found that the effects of pulsed microwaves on central cholinergic activity are classically conditionable to cues in the exposure environment. The hypothesis that some of the neurological effects of pulsed microwave irradiation are caused by its effect on the auditory system was investigated. Effects of pink noise and pulsed microwaves were compared.

1986-07-01

433

The benefits of low level radiation

In order to investigate the effect of humidity on laminar burning velocity(S), the effect of humidity on the combustion reaction and radiation intensity was studied, taking account of dilution gases such as CO/sub 2/ and Ar which has the approximately identical characteristics to exhaust gas circulation(EGR) gas used to prevent NOx discharge from engines. According to the heat reaction theory, mean specific heat(C) of mixture, mean molecular weight(M) and adiabatic flame temperature(T) etc. were said to affect S but from experimental results, the effect of M and C could be ignored, compared with the effect of T. The relationship between S and H/sub 2/O, Ar of CO/sub 2/% in mixture of diluted gases was clarified. The effect of H/sub 2/O on S was mainly caused by changes of T. The effect of radical C/sub 2/, CH and OH on radiation intensity was similar to that of ...

1987-08-25

434

Nucleon and meson effective masses in the relativistic mean-field theory

The assumed linear relationship between exposure to radiation and cancer incidence is questioned in this article. The current research data on radiation effects at the cellular level is reviewed, as are epidemiological studies of background radiation effects and health effects of populations exposed to low levels of radiation exposure via employment or medical treatments. Statistics reveal that threshold levels currently in force need to be reviewed. Some evidence of beneficial effects of low level radiation exposure effects of low level radiation exposure is also presented, and so regulations should be reviewed at an international level. (UK).

1997-06-01

435

Nucleon and meson effective masses in the relativistic mean-field theory

Nucleon and meson effective masses in the nonlinear relativistic mean-field theory introducing a nonlinear {omega}-{rho} and {sigma} coupling motivated by the quark-meson coupling model is explored. It is shown that, in contrast to the usual Walecka model, not only the effective nucleon mass m{sub eff,N} but also the effective {sigma},{rho} meson masses (m{sub eff{sigma}},m{sub eff,{rho}}) and the effective {omega} meson mass m{sub eff,{omega}} are nucleon density dependent. (author)

2001-10-01

436

Gravitational Waves and the Sagnac Effect

Nucleon and meson effective masses in the nonlinear relativistic mean-field theory introducing a nonlinear #omega#-#rho# and #sigma# coupling motivated by the quark-meson coupling model is explored. It is shown that, in contrast to the usual Walecka model, not only the effective nucleon mass m_e_f_f_,_N but also the effective #sigma#,#rho# meson masses (m_e_f_f_#sigma#,m_e_f_f_,_#rho#) and the effective #omega# meson mass m_e_f_f_,_#omega# are nucleon density dependent. (author)

2001-10-01

437

Effects of focused ion beam milling on the nanomechanical behavior of a molybdenum-alloy single crystal

We consider light waves propagating clockwise and other light waves propagating counterclockwise around a closed path in a plane (theoretically with the help of stationary mirrors). The time difference between the two light propagating path orientations constitutes the Sagnac effect. The general relativistic expression for the Sagnac effect is discussed. It is shown that a gravitational wave incident to the light beams at an arbitrary angle will not induce a Sagnac effect so long as the wave length of the weak gravitational wave is long on the length scale of the closed light beam paths. The gravitational wave induced Sagnac effect is thereby null.

2003-01-01

438

Transuranium isotopes production and their effect on the three-dimensional core calculation

Nanoindentation was performed on a Mo-alloy single crystal to investigate effects of focused ion beam (FIB) milling on mechanical behavior. On a non-FIB-milled surface, pop-ins were observed on all load-displacement curves corresponding to a transition from elastic to plastic deformation. Similar pop-ins were not detected on surfaces subjected to FIB milling. This difference indicates that FIB milling introduces damage that obviates the need for dislocation nucleation during subsequent deformation. A second effect of FIB milling is that it increased the surface hardness. Together, these effects could be the source of the size effects reported in the literature on micropillar tests.

2007-09-10

439

Transuranium isotopes production and their effect on the three-dimensional core calculation

The operation of a nuclear power reactor necessarily implies the consumption or burnup of reactor fuel by fission and capture, which gives rise to a decrease in the reactivity of the reactor. The effect of americium formation on the criticality of a thermal power reactor using two types of fuel is studied. The three-dimensional core calculation is used to calculate the production of the transuranium isotopes and their effect on the effective multiplication factor (K[sub eff]). This effect cannot be neglected for thermal power reactors with UO[sub 2]-PuO[sub 2] fuel (3.11% after 70 weeks of operation). The effect of the transuranium isotopes on the K[sub eff] for a thermal power reactor with UO[sub 2] fuel is about 0.0018% and can be ignored. (author).

1993-02-01

440

Psychological ownership and affective reaction: Emotional attachment process variables and the endowment effect

The operation of a nuclear power reactor necessarily implies the consumption or burnup of reactor fuel by fission and capture, which gives rise to a decrease in the reactivity of the reactor. The effect of americium formation on the criticality of a thermal power reactor using two types of fuel is studied. The three-dimensional core calculation is used to calculate the production of the transuranium isotopes and their effect on the effective multiplication factor (K_e_f_f). This effect cannot be neglected for thermal power reactors with UO_2-PuO_2 fuel (3.11% after 70 weeks of operation). The effect of the transuranium isotopes on the K_e_f_f for a thermal power reactor with UO_2 fuel is about 0.0018% and can be ignored. (author).

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441

British Library Electronic Table of Contents (United Kingdom)

This research proposes that the concept of emotional attachment, and specifically the independent constructs of psychological ownership and affective reaction, can help explain many of the endowment effect findings documented in the literature. We define these constructs and then test them across a set of nine studies in which we both replicate previous and generate new endowment effect findings, and then show that psychological ownership and affective reaction can mediate the effects. In doing so, we offer direct empirical support for the idea of emotional attachment as a driver of loss aversion while also providing practitioners and future endowment effect researchers with new insights about the psychological processes that underlie the endowment effect.

2011-01-01

442

Optical effects of fine-particle carbon on urban atmospheres

Numerical evaluation of effective unsaturated hydraulic properties for fractured rocks

The effects of fine-particle C, such as diesel soot, on the optical properties of urban haze in the visible wavelength range were explored to determine the dominant effects and to see if simple parameters (such as visual range in green) provide an adequate measure of these effects. It is known that fine-particle C absorbs more strongly in the blue than in the red, so that when it is mixed with a white pigment, the resulting gray can appear somewhat brown. The possibility of a similar effect in urban hazes was investigated, but found not to occur. When the sun is overhead, the near-horizon sky chromaticities caused by mixtures of fine-particle C and non-absorbing aerosol can also be produced by non-absorbing aerosols alone. It is shown that absorbing aerosol will darken the horizon sky, and a simple equation for the radiance of the horizon sky is derived. The effect of absorbing ...

1986-01-01

443

Locally resonant acoustic metamaterials with 2D anisotropic effective mass density

To represent a heterogeneous unsaturated fractured rock by its homogeneous equivalent, Monte Carlo simulations are used to obtain upscaled (effective) flow properties. In this study, we present a numerical procedure for upscaling the van Genuchten parameters of unsaturated fractured rocks by conducting Monte Carlo simulations of the unsaturated flow in a domain under gravity-dominated regime. The simulation domain can be chosen as the scale of block size in the field-scale modeling. The effective conductivity is computed from the steady-state flux at the lower boundary and plotted as a function of the averaging pressure head or saturation over the domain. The scatter plot is then fitted using van Genuchten model and three parameters, i.e., the saturated conductivity K{sub s}, the air-entry parameter {alpha}, the pore-size distribution parameter n, corresponding to this model are considered as the effective K{sub s}, ...

2009-01-01

444

British Library Electronic Table of Contents (United Kingdom)

A two-dimensional (2D) lattice model with anisotropic resonant microstructures is found to provide an anisotropic band gap structure. A 2D continuum with anisotropic effective mass density is introduced to represent this lattice system. Two methods are proposed to derive the equivalent continuum. In the first method, the effective mass density of the equivalent continuum is obtained by matching the dispersion relations for harmonic waves propagating in the principal directions. The second approach employs an approximate estimation of the effective mass density by volume-averaging an effective mass that represents the resonant microstructure. For both equivalent continuum models, the effective mass density is frequency-dependent and may become negative in certain frequency ranges. Subsequen...

2011-01-01

445

Hepatoprotective and anti-hepatocarcinogenic effects of glycyrrhizin and matrine

British Library Electronic Table of Contents (United Kingdom)

Matrine (Mat), a component extracted from Sophora flavescens Ait, has a wide spectrum of pharmacological effects. Glycyrrhizin (Gly), a major active constituent of licorice (Glycyrrhiza glabra) root, has various pharmacological effects. Gly and Mat are ancillary drugs used clinically in China for protection of liver function and treatment of tumors. However, habitual administration of Gly may cause adverse effects marked by the development of pseudohypercorticosteroidism. This work was designed to see whether combination use of Gly and Mat could offer better liver protective and anti-hepatocarcinogenic effects than Gly or Mat alone, and whether it could reduce the adverse effects of Gly alone by acetaminophen-induced hepatotoxicity, diethylnitrosamine-induced hepatocarcinogenesis, inductio...

2009-01-01

446

Field tests on partial embedment effects (embedment effect tests on soil-structure interaction)

Effective dose equivalent concept in radiopharmaceutical dosimetry

A series of Model Tests of Embedment Effect on Reactor Buildings has been carried out by the Nuclear Power Engineering Corporation (NUPEC), under the sponsorship of the Ministry of International Trade and lndustry (MITI) of Japan. The nuclear reactor buildings are partially embedded due to conditions for the construction or building arrangement in Japan. It is necessary to verify the partial embedment effects by experiments and analytical studies in order to incorporate the effects in the seismic design. Forced vibration tests, therefore, were performed using a model with several types of embedment. Correlated simulation analyses were also performed and the characteristics of partial embedment effects on soil-structure interaction were evaluated. (author)

1993-08-15

447

Effective dose equivalent concept in radiopharmaceutical dosimetry

The Effective Dose Equivalent Concept defined by the International Commission on Radiological Protection in 1977 considers the risk from irradiation including both hereditary and somatic effects. This paper will deal with the definition of a concept for somatic effects only, the somatically significant dose equivalent. This is defined as the dose equivalent which if received by every member of the population, would be expected to produce the same total somatic injury to the population as does the actual dose equivalent received by various individuals. The somatically effective dose equivalent for a particular radiopharmaceutical is the weighted sum of the average dose equivalent to various organs. The dose equivalent to various organs can be derived from an extended MIRD formalism also considering the rest of body excluding the source volumes and the re iden e times in total body and the target organs. ...

1981-06-01

448

Cost-effectiveness analysis for proposed effluent limitations guidelines and standards for the coastal subcategory of the oil and gas extraction point source category

The Effective Dose Equivalent Concept defined by the International Commission on Radiological Protection in 1977 considers the risk from irradiation including both hereditary and somatic effects. This paper will deal with the definition of a concept for somatic effects only, the somatically significant dose equivalent. This is defined as the dose equivalent which if received by every member of the population, would be expected to produce the same total somatic injury to the population as does the actual dose equivalent received by various individuals. The somatically effective dose equivalent for a particular radiopharmaceutical is the weighted sum of the average dose equivalent to various organs. The dose equivalent to various organs can be derived from an extended MIRD formalism also considering the rest of body excluding the source volumes and the re iden e times in total body and the target organs. ...

449

A hybrid solar desalination process of the multi-effect humidification dehumidification and basin-type unit

The analysis is submitted in support of the effluent limitations guidelines and standards for the Coastal Oil and Gas Industry. The report analyzes the cost-effectiveness of 10 regulatory options organized by three wastestreams. The document compares the total annualized cost incurred for each of the regulatory options within each wastestream to the corresponding effectiveness of that option in reducing the discharge of pollutants. Section Two discusses the cost-effectiveness methodology used and identifies the pollutants included in the analysis, presenting their toxic weighting factors and removal efficiencies. Section Three presents the results of the analysis. In Section Four, the cost-effectiveness values are compared to cost-effectiveness values for other promulgated rules. Appendix A presents data on pollutants, pollutant removals, annualized costs, and other, more detailed ...

1995-01-01

450

British Library Electronic Table of Contents (United Kingdom)

This paper presents a hybrid solar desalination process of the multi-effect humidification dehumidification and the basin-type unit. The sketch of the hybrid solar desalination process is given. The solar vacuated tube collector is employed in the desalination system, multi-effect humidification dehumidification desalination (HDD) process is plotted according to pinch technology, and then the water rejected from multi-effect HDD process is reused to desalinate in a basin-type unit further. The gain output ratio (GOR) of this system will rise by 2?3 at least through reusing the rejected water. The research proves that the multi-effect HDD has much room to be improved. A hybrid solar desalination process of the multi-effect humidification dehumidification and the basin-type unit should be no...

2008-01-01

451

Health effects models for nuclear power plant accident consequence analysis. Modification of models resulting from addition of effects of exposure to alpha-emitting radionuclides: Revision 1, Part 2, Scientific bases for health effects models, Addendum 2

X-ray dose enhancement effects

The Nuclear Regulatory Commission (NRC) has sponsored several studies to identify and quantify, through the use of models, the potential health effects of accidental releases of radionuclides from nuclear power plants. The Reactor Safety Study provided the basis for most of the earlier estimates related to these health effects. Subsequent efforts by NRC-supported groups resulted in improved health effects models that were published in the report entitled {open_quotes}Health Effects Models for Nuclear Power Plant Consequence Analysis{close_quotes}, NUREG/CR-4214, 1985 and revised further in the 1989 report NUREG/CR-4214, Rev. 1, Part 2. The health effects models presented in the 1989 NUREG/CR-4214 report were developed for exposure to low-linear energy transfer (LET) (beta and gamma) radiation based on the best scientific information available at that time. Since the 1989 report was ...

1993-05-01

452

The impact of water intake on energy intake and weight status: a systematic review

A brief description of the physical process of dose enhancement effects produced by X-ray radiation on materials is given, with emphasis on the influence on electronic devices. The damages caused by X-ray radiation dose enhancement is more serious than that of #gamma#-ray with higher energy.

453

The effects of thiamin on lead metabolism: organ distribution of lead 203.

The effects of consuming water with meals rather than drinking no beverage or various other beverages remains under-studied. This systematic review of English language studies compared the effects...Full Text Available

2010-09-01

454

The Effect of Reference Signals in a Visual Vigilance Task.

The effect of thiamin on the organ distribution of lead was evaluated in CD-1 mice exposed intragastrically or intraperitoneally to a single dose of lead acetate (100 micrograms) containing 100 microCi...Full Text Available

1992-07-01

455

The Effect of Live Classical Piano Music on the Vital Signs of Patients Undergoing Ophthalmic Surgery

The effect of reference signals on performance in a visual vigilance task was studied under three conditions. Reference signals were presented on the same display as the real signals. In condition 1 (control), no reference signals were displayed. Sugbject...

1969-01-01

456

The Effect of Different Timber Harvesting Techniques on Plethadontid Salamander Populations.

ContextMusic and surgery.ObjectiveTo determine the effect of live classical piano music on vital signs of patients undergoing ophthalmic surgery.DesignRetrospective...Full Text Available

457

THE EFFECTS OF RESPONSE EFFORT ON SAFE PERFORMANCE BY THERAPISTS AT AN AUTISM TREATMENT FACILITY

This investigation will explore the effect that current timber extraction techniques have on plethadontid salamander populations in ... group selection, and two-age harvest. Broad scale timber extraction can d...

458

Some aspects of the pharmacology of an homologous series of choline esters of fatty acids

The effects of response effort on safe behaviors (i.e., glove wearing, hand sanitizing, and electrical outlet replacement) exhibited by therapists at an autism treatment center were examined. Participants...Full Text Available

2010-01-01

459

Sexual differentiation of the zebra finch song system: potential roles for sex chromosome genes

The pharmacological effects of a series of fatty acid-choline esters have been studied on the isolated rabbit heart, the isolated guinea-pig ileum and the rat stomach. The effect changed with increasing...Full Text Available

1957-03-01

460

Sequential effects in two-choice reaction time tasks: Decomposition and synthesis of mechanisms

BackgroundRecent evidence suggests that some sex differences in brain and behavior might result from direct genetic effects, and not solely the result of the organizational effects...Full Text Available

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461

Reproductive Success of Cavity-nesting Birds Breeding under High-voltage Powerlines

Performance on serial tasks is influenced by first- and higher-order sequential effects, respectively due to the immediately previous and earlier trials. As response-to-stimulus interval (RSI)...Full Text Available

2009-09-01

462

Project resumes: biological effects from electric fields associated with high-voltage transmission lines

... biological effects of electromagnetic fields (EMFs) produced by high-voltage transmission lines have come under intense scrutiny, mostly with respect ... biological effects of electromagnetic fields (EMFs...

463

On the temperature dependence of the level density parameter and its effect upon neutron evaporation spectra

Abstracts of research projects are presented in the following areas: measurements and special facilities; cellular and subcellular studies; physiology; behavior; environmental effects; modeling, scaling and dosimetry; and high voltage direct current. (ACR)

1980-01-01

464

On the chiral effective meson-baryon Lagrangian at third order{sup *}

Effects associated with the temperature dependence of the level density parameter, a(T), are investigated in connection with neutron evaporation processes. Different approximations, for this temperature dependence, are compared for the case of neutron emission from the compound nucleus /sup 209/Pb.

1987-07-01

465

Near-infrared spectroscopy technique to evaluate the effects of red blood cell transfusion on tissue oxygenation

We show that the recently constructed complete and ''minimal'' third-order meson-baryon effective chiral Lagrangian can be further reduced from 84 to 78 independent operators. (orig.)

2006-09-15

466

Healthy worker effect in the total Finnish population.

IntroductionThe aim of this study was to evaluate the effects of red blood cell (RBC) transfusions on muscle tissue oxygenation, oxygen metabolism and microvascular reactivity in...Full Text Available

2009-01-01

467

H-1152 Effects on Intraocular Pressure and Trabecular Meshwork Morphology of Rat Eyes

The selection due to the "healthy worker effect" was estimated from a random sample of the total Finnish population. The sample of 20 000 people was followed for changes in occupations from 1960 to...Full Text Available

1980-05-01

468

AbstractPurposeThe aim of this study was to elucidate the effects of the Rho-kinase inhibitor, H-1152, on cultured human trabecular meshwork (HTM) cells, TM morphology,...Full Text Available

2008-08-01

469

Guidelines on exchangers

Genetic association between the COMT genotype and urinary levels of tea polyphenols and their metabolites among daily green tea drinkers

Experience has shown that a list of tips provides designers and engineers with an effective guide in their areas of duties and concern. This list contains new and rare information on heat exchangers and heat recovery systems. The information presented can be used effectively with personal computers and pocket calculators and also conveniently translated into computer programs and nomographs.

1985-08-01

470

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

Available in vitro and animal studies have shown cancer protective effects of tea polyphenols. Recent study suggests a greater protective effect of green tea intake on breast cancer...Full Text Available

471

Flucton model with scaling breaking: EMC effect and lepton pair production on nuclei

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It is possible that the life-prolonging effects...Full Text Available

472

Female rats display dose-dependent differences to the rewarding and aversive effects of nicotine in an age-, hormone-, and sex-dependent manner

The EMS effect is explained in the flucton model as a consequence of scale invariance violation. Nontrivial behaviour of the ratio between structural functions and production cross sections for lepton pairs for different nuclei at x > 1 is predicted.

473

Exposure to nitroaromatic explosives and health effects during disposal of military waste

IntroductionThe objective of this study was to examine age-, hormone-, and sex-dependent differences to the behavioral effects of nicotine using place-conditioning...Full Text Available

2009-10-01

474

Erythrocyte transketolase activity in suspected cases of Leigh's disease, or subacute necrotising encephalomyelopathy.

Aims: To investigate the exposure to dinitrotoluene (DNT) and trinitrotoluene (TNT) and the resulting effects in workers which occur during the disposal of military waste. Methods:...Full Text Available

2003-07-01

475

Effects of acute dieldrin exposure on neurotransmitters and global gene transcription in largemouth bass (Micropterus salmoides) hypothalamus

Erythrocyte transketolase activity and the effect of adding thiamine pyrophosphate (% thiamine pyrophosphate effect) were measured in 111 subjects suspected to suffer from Leigh's disease (subacute...Full Text Available

1980-10-01

476

Effects of a community mental health service on the practice and attitudes of general practitioners.

Exposure to dieldrin induces neurotoxic effects in the vertebrate CNS and disrupts reproductive processes in teleost fish. Reproductive impairment observed in fish by dieldrin is likely the...Full Text Available

2010-08-01

477

Effects of Daily Morphine Administration and Deprivation on Choice and Demand for Remifentanil and Cocaine in Rhesus Monkeys

Recent years have seen closer links developing between general practitioners and mental health specialists. A study was undertaken in Manchester to determine the effects of a new community mental health...Full Text Available

1993-12-01

478

Effects of Age on Optical Coherence Tomography Measurements of Healthy Retinal Nerve Fiber Layer, Macula and Optic Nerve Head

Choice procedures have indicated that the relative reinforcing effectiveness of opioid drugs increases during opioid withdrawal. The demand curve, an absolute measure of reinforcer value, has not been...Full Text Available

2011-01-01

479

Effective Reduced Diffusion-Models: A Data Driven Approach to the Analysis of Neuronal Dynamics

PurposeTo determine the effects of age on global and sectoral peripapillary retinal nerve fiber layer (RNFL), macular thicknesses and optic nerve head (ONH) parameters...Full Text Available

2009-06-01

480

Effect of lead on erythrocyte membranes.

We introduce in this paper a new method for reducing neurodynamical data to an effective diffusion equation, either experimentally or using simulations of biophysically detailed models. The dimensionality...Full Text Available

2009-12-01

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481

Effect of household and village characteristics on financial catastrophe and impoverishment due to health care spending in Western and Central Rural China: A multilevel analysis

The effect of blood lead on erythrocyte membrane proteins was studied in 28 workers from a scrap lead refining factory and in 18 controls working in railway construction. Sodium dodecyl sulphate-polyacrylamide...Full Text Available

1983-05-01

482

Effect of forced swimming stress on in-vivo fertilization capacity of rat and subsequent offspring quality

ObjectiveThe study aimed to examine the effect of household and community characteristics on financial catastrophe and impoverishment due to health payment in Western and Central...Full Text Available

483

Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice

AIMS:This study aimed to determine the effect of 50 days of forced swimming stress on fertilization capacity of rat and subsequent offspring quality.SETTING...Full Text Available

2010-01-01

484

Effect of association processes on polymerization of N-[3-(dimethylamino)propyl]methacrylamide salts in aqueous solutions

Chemoprevention strategies to prevent the development of lung cancer in at-risk individuals are a key component in disease management. In addition to being highly effective, an ideal chemopreventive...Full Text Available

2008-08-01

485

British Library Electronic Table of Contents (United Kingdom)

The effect of associative interactions of monomers and propagating macroradicals in homopolymerization of N-[3-(dimethylamino)propyl]methacrylamide salts and their copolymerization with acrylonitrile and acrylamide in aqueous solution was studied.

2010-01-01

486

Effect of Heat Treatment on Some Mechanical Properties of Laminated Window Profiles Manufactured Using Two Types of Adhesives

Effect of #gamma#-irradiation on relaxation properties of sealants on organosilicon rubber base

The mechanical properties of laminated window profiles manufactured using two types of adhesives were determined. The objective of this study is to evaluate the effects of heat treatment on some mechanical...Full Text Available

487

Ecological relevance of air pollution abatement measures as a decision aid

The dielectrical properties of organosilicon sealants have been studied in the wide range of temperatures in the low and radio frequencies range. The effect of thermal treatment and #gamma#-irradiation on these properties is discussed.

488

EFFECT OF THE DIGENEAN PARASITE PROTEROMETRA MACROSTOMA ON HOST MORPHOLOGY IN THE FRESHWATER SNAIL ELIMIA LIVESCENS

Air pollution abatement measures are not an end in themselves, and undesirable side effects should be taken into account. The proposed emission index takes into account the total emissions caused by a technical project as well as the effects of the individual pollutants.

1983-01-01

489

Comparison of the Maturation of the Adrenergic and Serotonergic Neurotransmitter Systems in the Brain: Implications for Differential Drug Effects on Juveniles and Adults

... 1984; Martin-Mora et al., 1995), and parasitism (Rothschild and Rothschild, 1939; Pesigan et al., 1958; Moose, 1963; Pan, ... effects of digeneans are variable; they may enhance (Rothschild and Rothschild...

490

Characterization of the stimulatory effect of high-fat diets on peroxisomal beta-oxidation in rat liver.

Our understanding of the development of neurotransmitter systems in the central nervous system has increased greatly over the past three decades and it has become apparent that drug effects...Full Text Available

2007-04-15

491

Biomarkers Signal Contaminant Effects on the Organs of English Sole (Parophrys vetulus) from Puget Sound

1. The effect on rat liver peroxisomal beta-oxidation of feeding diets containing various amounts of dietary oils was investigated. With increasing amounts (5-25%, w/w) of soya-bean oil an apparent,...Full Text Available

1982-08-15

492

Attenuation of Cocaine's Reinforcing and Discriminative Stimulus Effects via Muscarinic M₁ Acetylcholine Receptor StimulationS?

Fish living in contaminated environments accumulate toxic chemicals in their tissues. Biomarkers are needed to identify the resulting health effects, particularly focusing on early changes at a subcellular...Full Text Available

2006-06-01

493

Assessing and Compensating for Zero-lag Correlation Effects in Time-lagged Granger Causality Analysis of fMRI

Muscarinic cholinergic receptors modulate dopaminergic function in brain pathways thought to mediate cocaine's abuse-related effects. Here, we sought to confirm and ...Full Text Available

2010-01-01

494

An argument for the chicken embryo as a model for the developmental toxicological effects of the polyhalogenated aromatic hydrocarbons (PHAHs)

Effective connectivity in brain networks can be studied using Granger causality analysis which is based on temporal precedence, while functional connectivity is usually derived using zero-lag...Full Text Available

2010-06-01

495

Actual and Potential Effects of Medical Resident Coverage on Reimbursement for Inpatient Visits by Attending Physicians

This article will present the argument that the chicken embryo is especially appropriate as an animal model for studying the mechanism of the developmental toxicological effects of the polyhalogenated aromatic hydrocarbons (PHAHs). The PHAHs are a group of toxicologically related compounds including, in part, the polychlorinated dibenzodioxins, dibenzofurans and biphenyls. The chicken (Gallus gallus) embryo is relatively sensitive to the toxicological effects of the PHAHs being approximately two orders of magnitude more sensitive than the mature bird. The chicken embryo has been used to demonstrate general toxicological teratogeneicity, hepatotoxicity and neurotoxicity. Many of these effects, or analogous effects, have also been observed in mammals and fish. Thus, most animals appear to respond to the PHAHs with a similar toxicological profile, indicating that many of the biomarkers used for the PHAHs ...

1996-12-31

496

Access Intervention in an Integrated, Prepaid Group Practice: Effects on Primary Care Physician Productivity

CONTEXTThe impact of residents on hospital finance has been studied; there are no data describing the economic effect of residents on attending physicians.OBJECTIVEIn...Full Text Available

2002-06-01

497

A tool to balance benefit and harm when deciding about adjuvant therapy

ObjectiveTo estimate the joint effect of a multifaceted access intervention on primary care physician (PCP) productivity in a large, integrated prepaid group practice.Data...Full Text Available

2008-10-01

498

A Motivation-Focused Weight Loss Maintenance Program is an Effective Alternative to a Skill-Based Approach

Adjuvant therapy aims to prevent outgrowth of residual disease but can induce serious side effects. Weighing conflicting treatment effects and communicating this information with patients is not elementary....Full Text Available

2009-03-24

499