Science.gov (United States)

Progress on Ultrasensitive fluorescence detection of DNA is briefly described. (CBS)

Energy Technology Data Exchange (ETDEWEB)

Brief item.

Energy Technology Data Exchange (ETDEWEB)

We propose a novel method for ultrasensitive isotope analysis that combines magnetic mass selection, resonant charge-exchange neutralization, and resonant laser ionizaion. Our method attains high isotopic abundance selectivity by means of continuous multistage separation of ions stored in a small ring. For the environmentally interesting case of /sup 90/Sr versus /sup 88/Sr we estimate that sensitivity better than 10/sup -15/ for a throughput of 10/sup 13/ atoms/sec and an efficiency (after the ion source) greater than 10% are readily achievable.

KoreaScience (Korea)

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UK PubMed Central (United Kingdom)

The objective of this study was to develop a specific immunological diagnostic assay for yellow disease in hyacinths, using monoclonal antibodies (MAbs). Mice were immunized with a crude cell wall preparation...Full Text Available

KoreaScience (Korea)

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UK PubMed Central (United Kingdom)

Anti-TAG-72 monoclonal antibodies target the tumor-associated glycoprotein (TAG)-72 in various solid tumors. This study evaluated the use of anti-TAG-72 monoclonal antibodies, both murine CC49...Full Text Available

UK PubMed Central (United Kingdom)

The success of monoclonal antibodies in clinical practice is dependent on good design. Finding a suitable target is the most important part as other properties of the antibody can be altered by genetic...Full Text Available

UK PubMed Central (United Kingdom)

Two monoclonal antibodies, TAL-1B5 and TAL-3C3, specific for human Ia alpha-chain subunits have been produced by fusing P3/NSI/1-Ag4-1 mouse myeloma cells with spleen cells from a BALB/c mouse immunized...Full Text Available

UK PubMed Central (United Kingdom)

Monoclonal antibodies (mAb) to ovine T-lymphocyte molecules SBU-T8 (Maddox, Mackay & Brandon, 1985), the cytotoxic T lymphocyte, human CD8 equivalent, and SBU-T6 (Mackay et al., 1985), the immature...Full Text Available

International Nuclear Information System (INIS)

Antibodies directed against markers on cancer cells are gaining in importance for the purpose of targeting diagnostic and therapeutic agents. In the past, this approach has had very limited success principally because the classical methods for producing antibodies from blood serum of animals immunized with cancer cells or extracts were unsatisfactory. The situation has changed dramatically since 1975 following the design of procedures for 'immortalizing' antibody-producing cells (lymphocytes) by fusing them with cultured myeloma cells to form hybridomas which continuously secrete antibodies. Since these hybridomas produce antibodies coded for by a single antibody-producing cell, the antibodies are called monoclonal. Building on these advances in biomedical research, it is now possible to reproducibly manufacture monoclonal antibodies on a scale suitable for use in cancer detection and therapy.

UK PubMed Central (United Kingdom)

A monoclonal antibody raised against carboxyl-linked IAA was used in Western blot analysis of storage proteins from kernels of Avena sativa, Pennisetum americanum, Sorghum bicolor,...Full Text Available

UK PubMed Central (United Kingdom)

Epidermal growth factor receptor (EGFR) related therapies – mainly tyrosine kinase inhibitors (TKIs) such as erlotinib and gefitinib, but also monoclonal antibodies targeting EGFR, for example,...Full Text Available

UK PubMed Central (United Kingdom)

An immunoglobulin Mk monoclonal (F8IVE9) antibody raised against oat (Avena sativa cv Garry) root homogenate has been produced and characterized. The predominant target...Full Text Available

UK PubMed Central (United Kingdom)

Colonies of toxin-producing Pasteurella multocida were detected with peroxidase-labeled monoclonal antibodies by a membrane assay. Examination of the specificity of the assay with 29 P. multocida cultures...Full Text Available

UK PubMed Central (United Kingdom)

SummaryMonoclonal antibodies are standard therapeutics for several cancers including the anti-CD20 antibody rituximab for B cell non-Hodgkin lymphoma (NHL). Rituximab and other...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundFeature selection is an important pre-processing task in the analysis of complex data. Selecting an appropriate subset of features can improve classification or clustering...Full Text Available

Science.gov (United States)

7.5.6 Conclusions of the Generic Metroplex Queueing Simulation . ...... the systemwide arrival delays incurred at the metroplex terminal-area ...... assignment rules, estimated nominal transit speeds or times by domain, and stochastic ...

British Library Electronic Table of Contents (United Kingdom)

In mammals, primordial germ cells (PGCs) are generated in the extra-embryonic epiblast, and thereafter migrate into the developing gonads. Following the development of the gonads to the testes or ovaries, germ cells mature into sperms or eggs. In the present study, we report production and characterization of monoclonal antibodies (MAb) that recognize PGCs. Extracts from E12.5 mouse embryonic gonads were immunized as an antigen, and hybridomas were generated using the rat medial iliac lymph node method. The hybridoma supernatants were screened by immunohistochemical analyses of E12.5 mouse embryonic sections. The antibody, referred to herein as MAb 5B5, provided strong signals on PGCs. Moreover, immunofluorescence analyses using a variety of the tissue sections of mouse embryos revealed th...

Energy Technology Data Exchange (ETDEWEB)

W have introduced template-synthesized metal phosphate nanoparticle labels for electrochemical immunoassay. Such use of an apoferritin template offers a simple and convenient route to prepare metallic nanoparticle labels for electrochemical immunoassays and avoid the complicated and time-consuming nanoparticle synthesis process (QD synthesis). Releasing metal ions from metal phosphate in an acetate buffer (pH 4.6) eliminates the harsh condition in the traditional metallic nanoparticle dissolution (e.g., strong acid dissolution of QDs and gold nanoparticles). This method is ultrasensitive and its DL is low to 77fM. The simultaneous detection of multiple protein targets is easily performed by using different metal phosphate nanoparticle labels (cadmium phosphate and lead phosphate). This approach can be extended to prepare multiple metal (such as zinc, lead, cadmium, copper, indium, gold, silver) phosphate nanoparticle labels or hybrid metal (bimetallic or ...

International Nuclear Information System (INIS)

Lead-203 [52.1 h, 279 (80.1%) KeV] has been recognized as a potentially useful tracer for tumor specific radiopharmaceuticals due to its favorable nuclear and chemical properties. This paper reports the cyclotron production of lead-203 and the labelling of monoclonal antibody B72.3, conjugated with 2-(p-isothiocyanatobenzyl)DOTA, with lead-203 in 30% yield. In vivo biodistribution and stability studies in mice are being conducted.

UK PubMed Central (United Kingdom)

Ocular and urogenital tract infections with Chlamydia trachomatis can progress to chronic inflammatory diseases that produce blindness and tubal infertility. The pathophysiology of these chronic disease...Full Text Available

International Nuclear Information System (INIS)

The term 'health/functional food' (HFF) refers to food supplements containing nutrients or other substances (in a concentrated form) that have a nutritional or physiological effect whose purpose is to supplement the normal diet. The Korean Health/Functional Food Act that came into effect in 2004 requires these products to be marketed in measured doses, such as in pills, tablets, capsules, and liquids. HFFs are of two types: generic and product-specific. There are 37 ingredients listed in the act for generic HFFs, and if an HFF contains a new active ingredient that is not included in the generic 37 products, it is considered a product-specific HFF. The standardization, safety, and efficacy of a new active ingredient are reviewed by the Korean Food and Drug Administration in order to receive approval as a product-specific HFF. Conforming with international standards and protecting public health requires constant upgrading of ...

CERN Document Server

The study of quantum walk process has been widely divided into the two standard variants, the discrete-time quantum walk (DTQW) and the continuous-time quantum walk (CTQW). The connection between the two variants has been established by considering limiting value of the coin operation parameter in the DTQW and the coin degree of freedom is show to be unnecessary [26]. But the coin degree of freedom is an additional resource which can be exploited to control the dynamics of the QW process. In this paper we present a generic quantum walk (QW) model using a quantum coin-embedded unitary shift operation U_{C}. The standard version of the DTQW and the CTQW can be conveniently retrieved from this generic model retaining the features of the coin degree of freedom in both the variants.

International Nuclear Information System (INIS)

The paper gives a generic idea of the solutions that the neuronal nets contribute to the robotics. The advantages and the inconveniences are exposed that have regarding the conventional techniques. It also describe the more excellent applications as the pursuit of trajectories, the positioning based on images, the force control or of the mobile robots management, among others

UK PubMed Central (United Kingdom)

PurposeTo develop a generic instrument for measuring short-term health status in the recovery period among patients undergoing abdominal and pelvic surgery.Full Text Available

Science.gov (United States)

Adaptive Neural Augmentation , AIAA Guidance, Navigation, and. Control Conference, Aug. 1998. [2] J. T. Kaneshige, J. Bull, and J. J. Totah, Generic Neural ...

Energy Technology Data Exchange (ETDEWEB)

We consider the dynamics toward the initial singularity of Bianchi type IX vacuum and orthogonal perfect fluid models with a linear equation of state. The 'Bianchi type IX attractor theorem' states that the past asymptotic behavior of generic type IX solutions is governed by Bianchi type I and II vacuum states (Mixmaster attractor). We give a comparatively short and self-contained new proof of this theorem. The proof we give is interesting in itself, but more importantly it illustrates and emphasizes that type IX is special, and to some extent misleading when one considers the broader context of generic models without symmetries.

CERN Document Server

We consider the dynamics towards the initial singularity of Bianchi type IX vacuum and orthogonal perfect fluid models with a linear equation of state. The `Bianchi type IX attractor theorem' states that the past asymptotic behavior of generic type IX solutions is governed by Bianchi type I and II vacuum states (Mixmaster attractor). We give a comparatively short and self-contained new proof of this theorem. The proof we give is interesting in itself, but more importantly it illustrates and emphasizes that type IX is special, and to some extent misleading when one considers the broader context of generic models without symmetries.

International Nuclear Information System (INIS)

Of the radionuclides with physical properties most suited for use with monoclonal antibody for tumor imaging or therapy, few are more available or desirable than Pb-203, 212 and Bi-212. Yet no clinical studies have as yet been possible solely due to the lability in vivo of known complexes. We now report that bismuth complexes of the ligands p-SCN-Bz-DOTA and p-SCN-Bz-trans-cyclohexylDTPA are effective at protecting Bi-206 from release when linked to immunoproteins. Practicable, efficient ligand syntheses will be reported. Initial studies reveal that antibody is labeled efficiently with radiolead DOTA complexes. Preliminary studies indicate stability in vivo.

International Nuclear Information System (INIS)

The detection and quantification of defined reaction products of chemical mutagens and carcinogens (and of many cancer chemotherapeutic agents) with DNA require highly sensitive analytical techniques. The exceptional capability of immunoglobulins to recognize subtle alterations of molecular structure (especially when monoclonal antibodies are used to maximize specificity), outstanding sensitivity of immunoanalysis by high-affinity antibodies, and the fact that radioactively-labelled agents are not required suggest the utility of a radioimmunoassay to recognize and quantitate alkylated DNA products. We have recently developed a set of high-affinity monoclonal antibodies (secreted by mouse x mouse as well as by rat x rat hybridomas; antibody affinity constants, 10"9 to > 10"1"0 lmol) specifically directed against several DNA alkylation products with possible relevance in relation to both mutagenesis and malignant transformation of mammalian ...

International Nuclear Information System (INIS)

To accomplish the environmental radiological surveillance need of India's ambitious nuclear power programme, Health Physics Division is infusing new technologies and improved analytical techniques for day to day measurements of various radionuclides in different environmental matrices. It is essential to have techniques for measuring the concentration of radionuclides just above the background level since the discharges from the nuclear facilities are very low i.e. in the range of 5-10% of the prescribed discharge limits by the regulatory bodies. In view of developing ultra-sensitive techniques, the aim of ongoing programmes of the division is to meet the challenges of measuring ultra trace level of radioactivity by adopting state of art new instrumentation and improved sample processing techniques. This will allow us to measure the lowest level of radioactivity (3H, 90Sr, 137Cs, 239+240Pu, etc.) in the environment and thereby estimating the lowest doses to the ...

Energy Technology Data Exchange (ETDEWEB)

This report identifies individual contaminants and contaminant mixtures that have been measured in the ground at 91 waste sites at 18 US Department of Energy (DOE) facilities within the weapons complex. The inventory of chemicals and mixtures was used to identify generic chemical mixtures to be used by DOE's Subsurface Science Program in basic research on the subsurface geochemical and microbiological behavior of mixed contaminants (DOE 1990a and b). The generic mixtures contain specific radionuclides, metals, organic ligands, organic solvents, fuel hydrocarbons, and polychlorinated biphenyls (PCBs) in various binary and ternary combinations. The mixtures are representative of in-ground contaminant associations at DOE facilities that are likely to exhibit complex geochemical behavior as a result of intercontaminant reactions and/or microbiologic activity stimulated by organic substances. Use of the generic mixtures ...

Energy Technology Data Exchange (ETDEWEB)

Radium is known to be taken up by aquatic animals, and tends to accumulate in bone, shell and exoskeleton. The most common approach to estimating the uptake of a radionuclide by aquatic animals for use in health and environmental risk assessments is the concentration factor method. The concentration factor method relates the concentration of a contaminant in an organism to the concentration in the surrounding water. Site specific data are not usually available, and generic, default values are often used in risk assessment studies. This paper describes the concentration factor method, summarizes some of the variables which may influence the concentration factor for radium, reviews reported concentration factors measured in marine environments and presents concentration factors derived from data collected in a study in coastal Louisiana. The use of generic default values for the concentration factor is also discussed.

British Library Electronic Table of Contents (United Kingdom)

Motivation: High-throughput transcriptomics, proteomics and metabolomics methods have revolutionized our knowledge of biological systems. To gain knowledge from comparative omics studies, strong data integration and visualization features are required. Knowledge gained from these studies is often available in the form of graphs, and their visualization is especially useful in a wide range of systems biology topics, including pathway analysis, interaction networks or gene models. Especially, it is necessary to compare biological models with measured data. This allows the identification of new models and new insights into existing ones. Results: We present MGV, a versatile generic graph viewer for multiomics data. MGV is integrated into Mayday (Battke et al., 2010). It extends Maydays visual...

International Nuclear Information System (INIS)

Objective: To establish a computer program for rapid calculation of internal committed effective close through inhalation and ingestion pathways under radiological emergency. Methods: Visual Basic 6.0 is used to compile the generic procedures of internal committed effective dose by inhalation and ingestion in IAEA-TECDOC-1162, Generic Procedures for Assessment and Response during a Radiological Emergency. Results: The assessment methodology of internal committed effective dose by inhalation and ingestion under radiological emergency in the report IAEA-TECDOC-1162 can be coded into a computer program. Conclusions: This research provides a rapid method of assessment for internal committed effective dose by inhalation and ingestion under radiological emergency, and it may provide needed dosimetry data for treatment under emergency response. (authors)

Energy Technology Data Exchange (ETDEWEB)

This compilation contains 50 ACRS reports submitted to the Commission, Executive Director for Operations, or to the Office of Nuclear Regulatory Research, during calendar year 1992. It also includes a report to the Congress on the NRC Safety Research Program. All reports have been made available to the public through the NRC Public Document Room and the US Library of Congress. The reports are divided into two groups: Part 1: ACRS Reports on Project Reviews, and Part 2: ACRS Reports on Generic Subjects. Part I contains ACRS reports alphabetized by project name and by chronological order within project name. Part 2 categorizes the reports by the most appropriate generic subject area and by chronological order within subject area.

Energy Technology Data Exchange (ETDEWEB)

This compilation contains 41 Advisory Committee on Reactor Safeguards (ACRS) reports submitted to the Commission, Executive Director for Operations, or to the Office of Nuclear Regulatory Research, during calendar year 1991. It also includes a report to the Congress on the NRC Safety Research Program. All reports have been made available to the public through the NRC Public Document Room and the US Library of Congress. The reports are divided into two groups: Part 1: ACRS Reports on Project Reviews, and Part 2: ACRS Reports on Generic Subjects. Part 1 contains ACRS reports alphabetized by project name and by chronological order within project name. Part 2 categorizes the reports by the most appropriate generic subject area and by chronological order within subject area.

Energy Technology Data Exchange (ETDEWEB)

This compilation contains 54 ACRS reports submitted to the Commission or to the Executive Director for Operations during calendar year 1989. It also includes a report to the Congress on the NRC Safety Research Program. All reports have been made available to the public through the NRC Public Document Room and the US Library of Congress. The reports are divided into two groups: Part 1 -- ACRS Reports on Project Reviews, and Part 2 -- ACRS Reports on Generic Subjects. Part 1 contains ACRS reports alphabetized by project name and within project name by chronological order. Part 2 categorizes the reports by the most appropriate generic subject area and within subject area by chronological order.

Energy Technology Data Exchange (ETDEWEB)

This compilation contains 47 ACRS reports submitted to the Commission or to the Executive Director for Operations during calendar year 1987. It also includes a report to the Congress on the NRC Safety Research Program for FY 1988. All reports have been made available to the public through the NRC Public Document Room and the US Library of Congress. The reports are divided into two groups: Part 1: ACRS Reports on Project Reviews, and Part 2: ACRS Reports on Generic Subjects. Part 1 contains ACRS reports alphabetized by project name and within project name by chronological order. Part 2 categorizes the reports by the most appropriate generic subject area and within subject area by chronological order.

British Library Electronic Table of Contents (United Kingdom)

Abstract: We present a generic scoring system that compares the impact of alien species among members of large taxonomic groups. This scoring can be used to identify the most harmful alien species so that conservation measures to ameliorate their negative effects can be prioritized. For all alien mammals in Europe, we assessed impact reports as completely as possible. Impact was classified as either environmental or economic. We subdivided each of these categories into five subcategories (environmental: impact through competition, predation, hybridization, transmission of disease, and herbivory; economic: impact on agriculture, livestock, forestry, human health, and infrastructure). We assigned all impact reports to one of these 10 categories. All categories had impact scores that ranged f...

International Nuclear Information System (INIS)

A simple and rapid procedure was developed for the purification of cyclotron-produced "2"0"3Pb via the "2"0"3Tl(d,2n) "2"0"3Pb reaction. A Pb(II) selective ion-exchange resin, with commercial name Pb Resin from Eichrom Technologies, Inc., was used to purify "2"0"3Pb from the cyclotron-irradiated Tl target with excellent recovery of the enriched Tl target material. The purified "2"0"3Pb was used to radiolabel the monoclonal antibody Herceptin. The in vitro and in vivo properties of the "2"0"3Pb radioimmunoconjugate were evaluated.

International Nuclear Information System (INIS)

The human erythrocyte (RBC) Rh blood group system consists of a complex of distinct integral membrane polypeptides with physical properties common to the aminophospholipid transporter responsible for the transbilayer movement of phosphatidylserine (PS) in RBC. To assess the involvement of Rh polypeptides in PS translocation, the aminophospholipid translocase was labeled with a photoactivatable PS analogue, "1"2"5I-azido-PS, and with an inhibitor of PS transport, "1"2"5I-labeled 2-(2-pyridyldithio)ethylamine. The ability of monoclonal Rh antibodies to immunoprecipitate the labeled transporter was determined. Immunoprecipitated Rh polypeptides were found to be labeled with the aminophospholipid translocase markers, suggesting that Rh proteins are involved in the transbilayer movement of PS.

Energy Technology Data Exchange (ETDEWEB)

A chicken model was prepared that provides a simple and economical method of evaluating the use of fibrin-specific monoclonal antibody 64C5 in the detection of peripheral vascular thrombi. Human fibrin was clotted in segments of a chicken's femoral artery and vein prior to intravenous injection of radioiodinated antibody 64C5. After a 3-hr perfusion time, the thrombosed and contralateral control segments of the vessels were excised and counted for radioactivity. The radiolabeled 64C5 uptake ratio of the thrombosed segment to the control segment was 5.4 +/- 1.2 (p less than 0.007) in the femoral artery, and 3.8 +/- 1.1 (p less than 0.02) in the femoral vein. This in vivo chicken model may also find application in studies of targeting agents for human fibrin.

British Library Electronic Table of Contents (United Kingdom)

Abstract One of the most significant problems in industrial bioprocessing of recombinant proteins using engineered mammalian cells is the phenomenon of cell line instability, where a production cell line suffers a loss of specific productivity (qP). This phenomenon occurs with unpredictable kinetics and has been widely observed in Chinese hamster ovary (CHO) cell lines and with all commonly used gene expression systems. The underlying causes (both genetic and physiological) and the precise molecular mechanisms underpinning cell line instability have yet to be fully elucidated, although recombinant gene silencing and loss of recombinant gene copies have been shown to cause qP loss. In this work we have investigated the molecular mechanisms underpinning qP instability over long-term sub-cult...

Energy Technology Data Exchange (ETDEWEB)

We analyze spin correlations between top quark and anti-top quark produced at polarized e{sup +} e{sup -} and {gamma}{gamma} colliders. We consider a generic spin basis to find a strong spin correlation. Optimal spin decompositions for top quark pair are presented for e{sup +}e{sup -} and {gamma}{gamma} colliders. We show the cross- section in these bases and discuss the characteristics of results.

Energy Technology Data Exchange (ETDEWEB)

In 1991 the Federal Energy Regulatory Commission (FERC) continued it efforts to restructure the electric utility industry, emphasizing market-based pricing of wholesale power transactions and transmission access and pricing. Other issues covered in this report include pricing and policy initiatives, filing procedures, the generic rate of return on common equity, the price squeeze, contract interpretation, and legislative developments.

Energy Technology Data Exchange (ETDEWEB)

A generic insensitive fuze train to initiate insensitive high explosives, such as PBXW-124. The insensitive fuze train uses a slapper foil to initiate sub-gram quantities of an explosive, such as HNS-IV or PETN. This small amount of explosive drives a larger metal slapper onto a booster charge of an insensitive explosive, such as UF-TATB. The booster charge initiates a larger charge of an explosive, such as LX-17, which in turn, initiates the insensitive high explosive, such as PBXW-124.

Science.gov (United States)

Research programs in coal liquefaction are briefly discussed. The following projects are addressed: coal desulfurization by bioprocessing; materials characterization study of liquefaction processes; novel approaches to catalysis in coprocessing and in direct coal liquefaction; liquefaction research in pyrolysis catalysis, and coal dissolution; enhanced reactivity and selectivity in coal liquefaction and coprocessing systems. (CBS)

International Nuclear Information System (INIS)

Afterheat represents an important consideration in design of conceptual fusion power reactors, particularly during normal or unplanned shutdown. Afterheat calculations have been undertaken for various generic designs, but with special reference to the Culham DEMO reactor. These calculations have included the redistribution of heating by gamma ray transport. Selected temperature response calculations have been undertaken. (author).

Science.gov (United States)

Humoral immune response to human epidermal growth factor receptor 2 (HER-2/neu or ErbB-2) has been detected in sera of breast cancer patients and shown to be an appropriate prognostic marker (Taylor et al., 2007). However, since Trastuzumab (Herceptin) is a widely used monoclonal antibody as cancer therapy agent for tumors over-expressing HER-2, there is a need for an efficient way to detect host-generated antibodies against HER-2 without the confounding effect of Herceptin. Here we describe a screening method developed to decipher between host antibodies against HER-2 and that of Herceptin. By producing a series of truncation mutants within the epitope of Herceptin, we were able to inhibit this binding. We demonstrated also that by a three amino acid substitution (PPF?SSS) we were able to abrogate Herceptin binding while generating a highly conserved HER-2 extracellular domain (ECD). By producing a stable cell line that expresses this mutated form of the human ...

Energy Technology Data Exchange (ETDEWEB)

We have compared the kinetics for repair of UV-induced cyclobutane pyrimidine dimers in the DNA of keratinocytes in human skin and in cell culture. A small area of the buttocks of volunteers was exposed to UVB-irradiation and biopsies were taken at various time intervals. Epidermal keratinocytes in culture from the same subjects were exposed to UVC with doses chosen to elicit comparable yields of dimers in cellular DNA. The initial density of pyrimidine dimers and the kinetics of their removal were assessed utilizing the dimer-specific T4 endonuclease V and sedimentation of the unlabeled DNA through alkaline sucrose gradients. The position of DNA in the gradients was determined using a monoclonal antibody against random sequences of single-stranded DNA in a sensitive immunoassay. The initial dimer frequency was 3.9-6.7 per 10(8) daltons DNA. About 40% of the dimers were removed within 1 h, 70% in 6 h, and 90% in 24 h for both in vivo and in vitro samples. The early ...

Science.gov (United States)

A factor produced by the plerocercoid stage of S. mansonoides mimics some, but not all, of the actions reported for hGH. The biological actions of plerocercoid growth factor (PGF) suggest structural similarity to human GH (hGH). Plerocercoid membranes were solubilized, and PGF was purified more than 1000-fold by hGH receptor affinity chromatography. The ability of purified PGF to displace [125I]hGH from monoclonal antibodies specific for four distinct nonoverlapping antigenic determinants of hGH and from an anti-hGH polyclonal antibody was tested in liquid phase RIA. All of the hGH antibodies cross-reacted with PGF, with potencies ranging from more than 60% to less than 1% that of the hGH standard. Of the four major epitopes of hGH defined by the monoclonal antibodies used in this study, only one is not represented to a significant extent in PGF. The epitope of hGH that is only marginally present in PGF is highly conformationally dependent, and ...

Energy Technology Data Exchange (ETDEWEB)

Since the late 1970s, the Babcock & Wilcox (B & W) Owners Group (BWOG) has sponsored significant activities that address technical, economic, and licensing issues to ensure that the B & W nuclear steam supply system (NSSS) power plants operate until the end of their current plant licensed life and to preserve the license renewal option. It should be no surprise that the BWOG decided in late 1992 to aggressively pursue a license renewal effort. This effort, the Generic License Renewal Program (GLRP), has over the past 18 months contributed significantly to the industry`s license renewal initiative. The GLRP was established as a project with a full-time management organization within the BWOG structure. Its primary objective was the development and demonstration of an integrated plant assessment (IPA) process that would meet the requirements of the License Renewal Rule, published by the US Nuclear Regulatory Commission (NRC) in December 1991. The BWOG ...

International Nuclear Information System (INIS)

We consider realisations of Zamolodchikov's nonlinear W_3 algebra at the classical and quantum level. Recent work has produced gaugings of the classical W_3 algebra starting from a theory of n scalar fields #PHI#"i, given the existence of a set of coefficients d_i_j_k satisfying a certain algebraic identity. We note that a solution exists for each Jordan algebra determined by a cubic norm form, leading to an infinite family of 'generic' models for all n, plus four special cases with n = 5, 8, 14 and 26. Taking free-field ansaetze for the spin-two and spin-three currents, we then formulate the conditions for the quantum W_3 algebra to be satisfied. We show how the generic classical models may be extended to the quantum case for every n, reducing to the construction of Fateev and Zamolodchikov for n = 2. These models are seen to be examples of a completely general construction, which produces a realisation of W_3 from an arbitrary realisation of ...

Energy Technology Data Exchange (ETDEWEB)

Verification and validation issues have been perceived as important factors in the large scale deployment of knowledge-based digital systems for plant transient diagnostics and management. Research and development (R&D) is being performed on the IGENPRO package to resolve knowledge base issues. The IGENPRO approach is to structure the knowledge bases on generic thermal-hydraulic (T-H) first principles and not use the conventional event-basis structure. This allows for generic comprehensive knowledge, relatively small knowledge bases and above all the possibility of T-H system/plant independence. To demonstrate concept feasibility the knowledge structure has been implemented in the diagnostic module PRODIAG. Promising laboratory testing results have been obtained using data from the full scope Braidwood PWR operator training simulator. This knowledge structure is now being implemented in the transient management module PROMANA to treat ...

International Nuclear Information System (INIS)

The quantum behavior of the vacuum Bianchi type-IX universe with the cosmological constant is investigated in terms of the Ashtekar variables. An exact solution to the quantum Hamiltonian constraint in the holomorphic representation is given. This solution reduces to the Hartle-Hawking wave function in the spatially isotropic sector and extends in the triad representation to the classically forbidden region where the determinant of the spatial metric becomes negative. The analysis of the quantum Robertson-Walker universe indicates that if the superspace is extended to such a classically forbidden region, the holomorphic representation picks up some restricted class of solutions in general. This observation leads to a new ansatz on the boundary condition of the Universe. In particular, the behavior of the Lorentzian and Euclidean WKB orbits corresponding to the solution suggests a new picture on the semiclassical behavior of the quantum Universe: that the Universe is created from an ...

International Nuclear Information System (INIS)

The release rate of a nuclide from a reactor or a radioactive waste disposal plant at the accident is not steady, but varies with time. The various parameters of a nuclide migration into environment vary also day after day, or with the seasons. In such cases, dynamic behavior of the nuclide in the environment must be taken into consideration. It is difficult for a mathematical model to involve all of mechanisms for the nuclide migration. The environment for evaluation of doses are usually divided into some of compartments in which a nuclide concentration is uniform. Time variations of the nuclide concentration in the compartment are described in simultaneous differential equations. The nuclide concentration can be solved as a time function, and the radiation doses, therefore, can be estimated as a time function. Generic analysis code for dynamic compartment model (GACOM) is developed for the nuclide migration and the evaluation of doses in terrestrial biosphere. ...

Energy Technology Data Exchange (ETDEWEB)

A generic reactor model is used to examine the economic viability of electricity generation by magnetic fusion. The simple model uses components which are representative of those used in previous reactor studies of deuterium-tritium burning tokamaks, stellarators, bumpy tori, reverse field pinches and tandem mirrors. Conservative costing assumptions are made. The generic reactor is not a tokamak but rather it is intended to emphasize what is common to all magnetic fusion reactors. The reactor uses a superconducting toroidal coil set to produce the dominant magnetic field. To this extent it is a less good approximation to systems, such as the reversed field pinch in which the main field is produced by a plasma current. The main output of the study is the cost of electricity as a function of the weight and size of the fusion core - blanket, shield, structure and coils. The model shows that a 1200 MW/sub e/ power plant with a fusion core weight of ...

British Library Electronic Table of Contents (United Kingdom)

The Dynamic Analog Scale (DAS) is introduced as a technique for generating single-item measures of personality traits. The DAS is comprised of extensive trait definitions and an analog scale on which respondents simultaneously rate themselves and others. In two studies the Big Five personality traits were assessed with the DAS and compared to a multiple-item questionnaire that measured the same traits. Statistical analysis supported the validity of the DAS for predicting self-reported behavioral acts, drinking behaviors, affect, and religiosity in ways similar to the multiple-item questionnaire. Consistent with previous research, both studies supported the viability of measuring personality traits with single items.

CERN Document Server

Convexity/concavity properties of symbol error rates (SER) of the maximum likelihood detector operating in the AWGN channel (non-fading and fading) are studied. Generic conditions are identified under which the SER is a convex/concave function of the SNR. Universal bounds for the SER 1st and 2nd derivatives are obtained, which hold for arbitrary constellations and are tight for some of them. Applications of the results are discussed, which include optimum power allocation in spatial multiplexing systems, optimum power/time sharing to decrease or increase (jamming problem) error rate, and implication for fading channels.

Energy Technology Data Exchange (ETDEWEB)

The objective of the Korean Next Generation Reactor(KNGR) seismic design is to develop a standard design that can cover most of site characteristics in the world with the possible exception of areas of high seismicity. This seismic design was based on the current state-of-the-art as well as the current Nuclear Regulatory guidance. This paper provides a summary on the design parameters used in the KNGR seismic design. In addition, this paper discusses seismic design requirements, selection of generic soil sites, selection of design control motions, and soil-structure interaction(SSI) analyses for the KNGR Nuclear Island(NI) structures. (author). 16 refs., 8 figs.

CERN Document Server

We study non-standard interactions (NSIs) at reactor neutrino experiments, and in particular, the mimicking effects on \\theta_13. We present generic formulas for oscillation probabilities including NSIs from sources and detectors. Instructive mappings between the fundamental leptonic mixing parameters and the effective leptonic mixing parameters are established. In addition, NSI corrections to the mixing angles \\theta_13 and \\theta_12 are discussed in detailed. Finally, we show that, even for a vanishing \\theta_13, an oscillation phenomenon may still be observed in future short baseline reactor neutrino experiments, such as Double Chooz and Daya Bay, due to the existences of NSIs.

Energy Technology Data Exchange (ETDEWEB)

The technology based portion of the Advanced Turbine Systems Program (ATS) contains several subelements which address generic technology issues for land-based gas-turbine systems. One subelement is the Materials/ Manufacturing Technology Program which is coordinated by DOE Oak Ridge Operations and Oak Ridge National Laboratory (ORNL). The work in this subelement is being performed predominantly by industry with assistance from universities and the national laboratories. Projects in this sub-element are aimed toward hastening the incorporation of new materials and components in gas turbines.

Wastenet

...May 2011, 693-709 On the valuation of fader and discrete barrier options in Heston's stochastic volatility model by Susanne Griebsch & Uwe Wystup [Downloadable!... (restricted)] 863-881 Nonlinearities in stochastic clocks: trades and volume as subordinators of electronic markets by Rafael Velasco-Fuentes & Wing Lon Ng [...and estimation of stock prices and trading volume in Barndorff-Nielsen and Shephard stochastic volatility models by Friedrich Hubalek & Petra Posedel [Downloadable!... (restricted)] 665-691 Generic pricing of FX, inflation and stock options under stochastic interest rates and stochastic volatility by Alexander van Haastrecht & Antoon ...

International Nuclear Information System (INIS)

Conceptual fusion reactor studies over the past 10 to 15 years have projected systems that may be too large, complex, and costly to be of commercial interest. One main direction for improved fusion reactors points towards smaller, higher-power-density approaches. First-order economic issues (i.e., unit direct cost and cost of electricity) are used to support the need for more compact fusion reactors. A generic fusion physics/engineering/costing model is used to provide a quantiative basis for these arguments for specific fusion concepts.

Science.gov (United States)

Results of research programs in coal liquefaction are presented. Areas of research include: desulfurization by bioprocessing; characterization of coal liquefaction processes by XAFS spectroscopy; coprocessing of coal with heavy oil and petroleum residuals; liquefaction research in pyrolysis, catalysis and coal dissolution; novel catalysts; data base development; resource evaluation; depolymerization; solvent extraction and chromatography; correlations of liquefaction yields and coal structure. Individual projects are processed separately for the data bases. (CBS)

International Nuclear Information System (INIS)

The long term objective of the Oil Sands Business Unit of Alberta Energy is to pave the way for Alberta's bitumen production to reach 3 million barrels per day by 2020. This presentation described the national government's role in resource development. It was emphasized that since the Crown is the owner of the oil sands resource, it would benefit by providing strategic leadership and by generating a larger royalty base. The oil sands fiscal regime was described with reference to generic royalty, risk sharing, investment, and project economics. Business rule principles were also outlined along with criteria for project expansions. Both upstream and downstream challenges and opportunities were listed. 4 figs.

Energy Technology Data Exchange (ETDEWEB)

This compilation contains 47 ACRS reports submitted to the Commission, or to the Executive Director for Operations, during calendar year 1996. It also includes a report to the Congress on the NRC Safety Research Program. All reports have been made available to the public through the NRC Public Document Room, the U.S. Library of Congress, and the Internet at http://www.nrc.gov/ACRSACNW. The reports are divided into two groups: Part 1 contains ACRS reports by project name and by chronological order within project name. Part 2 categorizes the reports by the most appropriate generic subject area and by chronological order within subject area.

Energy Technology Data Exchange (ETDEWEB)

Fetal nucleated cells within maternal blood represent a potential source of fetal genes obtainable by venipuncture. The authors used monoclonal antibody against the transferrin receptor (TIR) to identify nucleated erythrocytes in the peripheral blood of pregnant women. Candidate fetal cells from 19 pregnancies were isolated by flow sorting at 12 1/2-17 weeks gestation. The DNA in these cells was amplified for a 222-base-pair (bp) sequence present on the short arm of the Y chromosome as proof that the cells were derived from the fetus. The amplified DNA was compared with standardized DNA concentrations. In the case of the female fetus, DNA prepared from samples at 32 weeks of gestation and cord blood at delivery also showed the presence of the Y chromosomal sequence, suggesting Y sequence mosaicism or translocation. In 10/12 cases where the 222-bp band was absent, the fetuses were female. Thus, they were successful in detecting the Y chromosomal sequence in 75% of ...

Energy Technology Data Exchange (ETDEWEB)

Monoclonal antibodies (MAbs) 19-9 and 73-3 specific for human colon adenocarcinoma were labelled with a high number of gadolinium atoms. Twenty five DTPA were chelated per MAb, with only slight loss of immunoreactivity. The NMR contrast agent Gd-25 DTPA-MAb 19-9 or 73-3 ((Gd) 17 mumole/kg, (MAb) 60 microM) was injected into nude mice bearing human colon adenocarcinoma (SW948). Tumors were removed 24 hr after injection and T1 was measured in vitro. T1 relaxation time varied according to MAb specificity against tumour targets; T1 decreased 20% for MAb 19-9 and MAb 73-3 with SW948 tumor. Imaging was performed with this model. Very good contrast was obtained 24 hr after Gd-25 DTPA-MAb injection.

Energy Technology Data Exchange (ETDEWEB)

The overall objective of this project has been to develop immunochemical methods to quantitate unique DNA base damages in order to facilitate studies on radiation-induced damage production and repair. Specifically, we have been using antibodies raised to damaged bases to quantitate unique lesions in model systems in order to evaluate their potential biological consequences. Our approach has been to synthesize modified nucleotides or nucleosides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits or to prepare monoclonal antibodies. We have been studying damages that are stable radiolysis products found in X-irradiated DNA and thus of potential biological consequence. Our aim is to build an in vitro and in vivo data base on the interactions between model DNA lesions and such cellular enzymes as DNA polymerases and repair endonucleases. Initial studies have focused on pyrimidine ring saturation products (thymine glycol.and ...

International Nuclear Information System (INIS)

We have previously shown that avian reovirus (ARV) #sigma#A and #sigma#NS proteins possess dsRNA and ssRNA binding activity and suggested that there are two epitopes on #sigma#A (I and II) and three epitopes (A, B, and C) on #sigma#NS. To further define the location of epitopes on #sigma#A and #sigma#NS proteins and to further elucidate the biological functions of these epitopes by using monoclonal antibodies (MAbs) 62, 1F9, H1E1, and 4A123 against the ARV S1133 strain, the full-length and deletion fragments of S2 and S4 genes of ARV generated by polymerase chain reaction (PCR) were cloned into pET32 expression vectors and the fusion proteins were overexpressed in Escherichia coli BL21 strain. Epitope mapping using MAbs and E. coli-expressed deletion fragments of #sigma#A and #sigma#NS of the ARV S1133 strain, synthetic peptides, and the cross reactivity of MAbs to heterologous ARV strains demonstrated that epitope II on #sigma#A was located at amino acid residues ...

Energy Technology Data Exchange (ETDEWEB)

The purpose of this project was to compile a bibliography of references containing environmental transuranic radionuclide data. The authors intent was to identify those parameters affecting transuranic radionuclide transport that may be generic and those that may be dependent on chemical form and/or environmental conditions. An understanding of the unique characteristics and similarities between source terms and environmental conditions relative to transuranic radionuclide transport and cycling will provide the ability to assess and predict the long term impact on man and the environment. An additional goal of the literature review, was to extract the ranges of environmental transuranic radionuclide data from the identified references for inclusion in a data base. Related to source term, these ranges of data can be used to calculate the dose to man from the radionuclides, and to perform uncertainty analyses on these dose assessments.

International Nuclear Information System (INIS)

This paper discusses how the U.S. Liquid Metal Reactor Development Program has been restructured to carry out R and D on advanced reactor technology. The program gives particular emphasis to improvements to reactor safety. The new directions are based on the technology of the integral fast reactor (IFR). Much of the basis for superior safety performance using IFR technology has been experimentally verified and aggressive programs continue in EBR-II and TREAT. Progress has been made in demonstrating both the metallic fuel and the new electrochemical processes of the IFR. The FFTF facility is converting to metallic fuel; however, FFTF also maintains a considerable U.S. program in oxide fuels. In addition, generic programs are continuing in steam generator testing, materials development, and with international cooperation, aqueous reprocessing.

CERN Document Server

This is a thought piece on data-intensive science requirements for databases and science centers. It argues that peta-scale datasets will be housed by science centers that provide substantial storage and processing for scientists who access the data via smart notebooks. Next-generation science instruments and simulations will generate these peta-scale datasets. The need to publish and share data and the need for generic analysis and visualization tools will finally create a convergence on common metadata standards. Database systems will be judged by their support of these metadata standards and by their ability to manage and access peta-scale datasets. The procedural stream-of-bytes-file-centric approach to data analysis is both too cumbersome and too serial for such large datasets. Non-procedural query and analysis of schematized self-describing data is both easier to use and allows much more parallelism.

CERN Document Server

We describe an analytic continuation of the Euclidean Grosse-Wulkenhaar and LSZ models which defines a one-parameter family of duality covariant noncommutative field theories interpolating between Euclidean and Minkowski space versions of these models, and provides an alternative regularization to the usual Feynman prescription. This regularization allows for a matrix model representation of the field theories in terms of a complex generalization of the usual basis of Landau wavefunctions. The corresponding propagators are calculated and identified with the Feynman propagators of the field theories. The regulated quantum field theories are shown to be UV/IR-duality covariant. We study the asymptotics of the regularized propagators in position and matrix space representations, and confirm that they generically possess a comparably good decay behaviour as in the Euclidean case.

CERN Document Server

We study perturbations of a Schwarzschild black hole in Chern-Simons modified gravity. We begin by showing that Birkhoff's theorem holds for a wide family of Chern-Simons coupling functions, a scalar field present in the theory that controls the strength of the Chern-Simons correction to the Einstein-Hilbert action. After decomposing the perturbations in spherical harmonics, we study the linearized modified field equations and find that axial and polar modes are coupled, in contrast to general relativity. The divergence of the modified equations leads to the Pontryagin constraint, which forces the vanishing of the Cunningham-Price-Moncrief master function associated with axial modes. We analyze the structure of these equations and find that the appearance of the Pontryagin constraint yields an overconstrained system that does not allow for generic black hole oscillations. We illustrate this situation by studying the case characterized by a canonical choice of the ...

CERN Document Server

In the paper we investigate a mathematical model describing the growth of tumor in the presence of immune response of a host organism. The dynamics of tumour and immune cells is based on the generic Michaelis-Menten kinetics describing interaction and competition between the tumour and the immune system. The appropriate phenomenological equation modeling cell-mediated immune surveillance against cancer is of the predator-prey form and within a given choice of parameters exhibits bistability. Under the influence of spontaneous weak fluctuations, the model may be analyzed in terms of a stochastic differential equation bearing the form of an overdamped Langevin-like dynamics in the external quasi-potential represented by a double well. We analyze properties of the system within the range of parameters for which the potential wells are of the same depth and when the additional perturbation describing a periodic treatment is insufficient to overcome the barrier height ...

Energy Technology Data Exchange (ETDEWEB)

We consider the dynamics towards the initial singularity of Bianchi type IX vacuum and orthogonal perfect fluid models with a linear equation of state. Surprisingly few facts are known about the 'Mixmaster' dynamics of these models, while at the same time most of the commonly held beliefs are rather vague. In this paper, we use Mixmaster facts as a base to build an infrastructure that makes it possible to sharpen the main Mixmaster beliefs. We formulate explicit conjectures concerning (i) the past asymptotic states of type IX solutions and (ii) the relevance of the Mixmaster/Kasner map for generic past asymptotic dynamics. The evidence for the conjectures is based on a study of the stochastic properties of this map in conjunction with dynamical systems techniques. We use a dynamical systems formulation, since this approach has so far been the only successful path to obtain theorems, but we also make comparisons with the 'metric' ...

CERN Document Server

The junction conditions for General Relativity in the presence of domain walls with intrinsic spin are derived in three and higher dimensions. A stress tensor and a spin current can be defined just by requiring the existence of a well defined volume element instead of an induced metric, so as to allow for generic torsion sources. In general, when the torsion is localized on the domain wall, it is necessary to relax the continuity of the tangential components of the vielbein. In fact it is found that the spin current is proportional to the jump in the vielbein and the stress-energy tensor is proportional to the jump in the spin connection. The consistency of the junction conditions implies a constraint between the direction of flow of energy and the orientation of the spin. As an application, we derive the circularly symmetric solutions for both the rotating string with tension and the spinning dust string in three dimensions. The rotating string with tension ...

CERN Document Server

ATLAS Experiment is an international collaboration where more than 37 countries, 172 institutes and laboratories, 2900 physicists, engineers, and computer scientists plus 700 students participate. The management of this teamwork involves several aspects such as institute contribution, employment records, members' appointment, authors' list, preparation and publication of papers and speakers nomination. Previously, most of the information was accessible by a limited group of people and the system used was not designed to handle new requirements easily. Moreover, developers had to face problems such as different terminology, diverse data modeling, heterogeneous databases and unlike users needs. Besides that, the maintenance has to be an easy task considering the long lifetime experiment and professionals turnover. The Glance system, a generic mechanism for accessing any database, acts as an intermediate layer isolating the user from the particularities of each ...

CERN Document Server

We study N=2 SuperVirasoro SCFT for the generic value of the central charge. The main tool is the nonstandard bosonisation suggested in \\ref\\rRoz{L. Rozansky a letter to M. Bershadsky, 1989}, \\ref\\rSeBGR{B. Gato-Rivera, A. Semikhatov Phys. Letts. B293 (1992) 72},\\ref\\rBLNW{M. Bershadsky, W. Lerche, D. Nemeshansky, N. Warner N=2 Extended superconformal structure of Gravity and W Gravity coupled to Matter HUTP-A034/92}. The free field resolutions for the irreducible representations are obtained; the characters of these representations are computed. The quantum hamiltonian reduction from the Kac-Moody $\\hat{sl}_k(2|1)$ to N=2 $SVir$ is constructed.

CERN Document Server

In these lecture notes we derive a generic holographic string theory realization of a p-wave superconductor and superfluid. For this purpose we also review basic D-brane physics, gauge/gravity methods at finite temperature, key concepts of superconductivity and recent progress in distinct realizations of holographic superconductors and superfluids. Then we focus on a D3/D7-brane construction yielding a superconducting or superfluid vector-condensate. The corresponding gauge theory is 3+1-dimensional N=2 supersymmetric Yang-Mills theory with SU(N) color and SU(2) flavor symmetry. It shows a second order phase transition to a phase in which a U(1) subgroup of the SU(2) symmetry is spontaneously broken and typical superconductivity signatures emerge, such as a conductivity (pseudo-)gap and the Meissner-Ochsenfeld effect. Condensates of this nature are comparable to those recently found experimentally in p-wave superconductors such as a ruthenate compound. A string ...

International Nuclear Information System (INIS)

The risks from mining and processing of ores is reviewed on a generic basis with particular reference to some of the confusions which can arise due to lack of consistency or common logic in the use of exclusion, exemption and clearance. The difference in exclusion and exemption are challenged by comparing doses received in high background radiation areas and the doses received from a mining practice. The common principle of risk to the human species is not applied consistently. The differences between IAEA recommendations and local regulatory conditions are compared, and the use of exemption levels as clearance levels is considered. A case study on management of mine tailings is presented with special focus on the use of clearance levels. In all areas of review the interpretation of regulation is subject to confusion resulting from inconsistencies which can distort free market economics. (author).

Energy Technology Data Exchange (ETDEWEB)

The commercialization of geothermal energy resources consists of a sequence of exploration, development, and utilization activities. Each of these activities are beset by both generic and project specific technical, environmental, and institutional constraints which must be adequately resolved before geothermal operations can be conducted. This report presents a summary of selected environmental activities conducted during the early planning stages of geothermal resource commercialization. Three representative activities are elaborated upon. These include preliminary environmental planning for geothermal energy development in the Medicine Lake Highlands of California; potential alternatives for non-electric use of the geothermal resource at East Mesa in Imperial County, California; and site specific studies of the impacts from using East Mesa geothermal fluids to irrigate selected crops and indigenous climax vegetation.

CERN Document Server

This paper discusses the application of L1-regularized maximum entropy modeling or SL1-Max [9] to multiclass categorization problems. A new modification to the SL1-Max fast sequential learning algorithm is proposed to handle conditional distributions. Furthermore, unlike most previous studies, the present research goes beyond a single type of conditional distribution. It describes and compares a variety of modeling assumptions about the class distribution (independent or exclusive) and various types of joint or conditional distributions. It results in a new methodology for combining binary regularized classifiers to achieve multiclass categorization. In this context, Maximum Entropy can be considered as a generic and efficient regularized classification tool that matches or outperforms the state-of-the art represented by AdaBoost and SVMs.

British Library Electronic Table of Contents (United Kingdom)

Phreatic groundwater pumping is affecting water availability for crops in areas with a shallow water table. This can reduce crop growth and so affect farm income. There is a need for a generic and transparent method to assess the agricultural damage caused by water table drawdown. This paper proposes such a method that consists of 'damage tables' relating agricultural production losses to the groundwater regime for different soil/crop combinations found in Northern Belgium. The damage tables are constructed based on numerous simulations with the agrohydrological model SWAP, in which the bottom boundary conditions are gradually changed to reflect different groundwater regimes. The credibility of the resulting metamodel is assessed in three ways: using (1) field data, (2) an existing local e...

Energy Technology Data Exchange (ETDEWEB)

The Consortium for Fossil Fuel Liquefaction Science (CFFLS) is a research consortium that includes five universities and a state energy laboratory. The membership is comprised of Auburn University, the University of Kentucky, the University of Pittsburgh, the University of Utah, West Virginia University, and the Kentucky Energy Cabinet Laboratory. The Consortium was formed in 1984 in response to the concern of the faculty and scientists at these institutions over the decline of coal liquefaction research in the United States, particularly long-range, basic research. Significant progress towards these goals was made in the current contract period. Major research accomplishments are presented on coal desulfurization, coprocessing, pyrolysis, enhanced reactivity, characterization, resource evaluation and database development. 108 refs., 90 figs., 38 tabs.

CERN Document Server

Magnetic fields appear to be a generic feature of the early universe and are a natural source of secondary CMB non-Gaussianity. In recent years the statistical nature of the stresses of a primordial magnetic field has been well studied. In this paper we confirm and extend these studies at one- and two-point level, and present analytical results for a wide range of power-law spectra. We also consider two non-power law cases of interest: a blue spectrum with an extended damping tail on small scales, which could be generated by the non-linear mixing of density and vorticity; and a red spectrum with a damping tail on large scales. We then briefly consider the CMB impacts that result from such fields. While this paper focuses on the one- and two-point moments, the techniques we employ are designed to ease the analysis of the full bispectra induced by primordial magnetic fields.

Energy Technology Data Exchange (ETDEWEB)

The objective of this work is to improve the process for CO{sub 2} capture by alkanolamine absorption/stripping by developing an alternative solvent, aqueous K{sub 2}CO{sub 3} promoted by piperazine. Thermodynamic modeling predicts that the heat of desorption of CO{sub 2} from 5m K+/2.5 PZ from 85 kJ/mole at 40 C to 30 kJ/mole at 120 C. Mass transfer modeling of this solvent suggests that carbonate and general salt concentration play a major role in catalyzing the rate of reaction of CO{sub 2} with piperazine. Stripper modeling suggests that with the multipressure stripper, the energy consumption with a generic solvent decreases by 15% as the heat of desorption is decreased from 23.8 to 18.5 kcal/gmol. A second pilot plant campaign with 5m K+/2.5 PZ was successfully completed.

British Library Electronic Table of Contents (United Kingdom)

The present paper concerns the development of a polymer electrolyte membrane (PEM) fuel cells model in order to analyse the behaviour of the cell varying its operating parameters such as temperature (70-120 ^oC), pressure (1-3 atm), relative humidity (35-100%) and CO content (0-200 ppm) in the feeding gas. The voltage output and the relative current of a generic PEM fuel cell has been predicted through a mathematical method based on semi-empirical correlations derived from the experimental data available in literature. The model has been implemented in a commercial process simulator (AspenPlus) and it has been validated by comparing the obtained results with further experimental data (not utilized for the model development). The comparison has underlined a good agreement with the experimen...

International Nuclear Information System (INIS)

Since the publication by the International Commission on Radiological Protection of revised recommendations which set out some general principles for intervention, some ideas have emerged which address interventions in the case of chronic exposure from contaminated lands. In the past there have been interventions proposed or carried out to rehabilitate land contaminated during the era of atmospheric nuclear weapon testing. Some of these interventions are reviewed in the context of these ideas and it is concluded that, by and large, reasonable outcomes have been achieved. The concept of a 'generic action level' (an effective dose of the order of 10 mSv#centre dot#a"-"1 to representative individuals in the critical group) may be useful in future to aid decision makers in determining whether intervention is appropriate. (author)

Science.gov (United States)

In the Advance Coal Liquefaction Concept Proposal (ACLCP) carbon monoxide (CO) and water have been proposed as the primary reagents in the pretreatment process. The main objective of this project is to develop a methodology for pretreating coal under mild conditions based on a combination of existing processes which have shown great promise in liquefaction, extraction and pyrolysis studies. The aim of this pretreatment process is to partially depolymerise the coal, eliminate oxygen and diminish the propensity for retograde reactions during subsequent liquefaction. The desirable outcome of the CO pretreatment step should be: (1) enhanced liquefaction activity and/or selectivity toward products of higher quality due to chemical modification of the coal structure; (2) cleaner downstream products; (3) overall improvement in operability and process economics.

Energy Technology Data Exchange (ETDEWEB)

Abstracts are presented for about 40 papers. The Fossil Energy Advanced Research and Technology Development Materials program is an integrated materials research activity of the fossil energy coal program, whose objective is to conduct R and D for all advanced coal conversion and utilization technologies. The program is aimed at understanding materials behavior in coal system environments and the development of new materials for improving plant operations and reliability. A generic approach is used for addressing multiple coal technologies; for example, the hot-gas particulate filter development is applicable to pressurized fluidized bed combustion, integrated coal gasification combined-cycle, coal combustion, and indirectly fired combined-cycle systems.

Energy Technology Data Exchange (ETDEWEB)

We perform a recursive reduction of one-loop n-point rank R tensor Feynman integrals [in short: (n,R)-integrals] for n{<=}6 with R{<=}n by representing (n,R)-integrals in terms of (n,R-1)- and (n-1,R-1)-integrals. We use the known representation of tensor integrals in terms of scalar integrals in higher dimension, which are then reduced by recurrence relations to integrals in generic dimension. With a systematic application of metric tensor representations in terms of chords, and by decomposing and recombining these representations, we find the recursive reduction for the tensors. The procedure represents a compact, sequential algorithm for numerical evaluations of tensor Feynman integrals appearing in next-to-leading order contributions to massless and massive three- and four-particle production at LHC and ILC, as well as at meson factories. (orig.)

British Library Electronic Table of Contents (United Kingdom)

IntroductionFocusing on people and organizations, this paper aims to contribute to offshore safety assessment by proposing a methodology to model causal relationships.MethodThe methodology is proposed in a general sense that it will be capable of accommodating modeling of multiple risk factors considered in offshore operations and will have the ability to deal with different types of data that may come from different resources. Reason's ?Swiss cheese?? model is used to form a generic offshore safety assessment framework, and Bayesian Network (BN) is tailored to fit into the framework to construct a causal relationship model. The proposed framework uses a five-level-structure model to address latent failures within the causal sequence of events. The five levels include Root causes level, Tr...

Energy Technology Data Exchange (ETDEWEB)

During LOCA (Loss of Coolant Accident) in design bases accident (DBA), emergency core coolant supplements form a recirculation sump and cooled core and containment. When the double ended guillotine Break (DEGB) at the hot leg near steam generator, due to the jet impingement discharge flow, the debris could be potentially generated at pipe or wall nearby steam generator and be transported to the recirculation sump. Therefore, the debris, such as insulations and paint chips, could be accumulated and be clogged in the recirculation sump screen. If debris is blocked the sump strainer, the pressure drop is increased at the screen so as to increase the pressure loss of ECCS (Emergency Core Cooling System) pump NPSH (Net positive suction head). It is potentially influenced to decrease the long-term cooling capability of the recirculation sump. The recirculation sump screen clogging accident has happened in BWR of USA and Sweden. Considering the important to safety, US NRC (Nuclear Safety ...

Science.gov (United States)

Up to the present, the generic values of the Common cause failure (CCF) event parameters have been used in most PSA projects for the Korean NPPs. However, the CCF analysis should be performed with plant specific information to meet Category II of the ASME PRA Standard. Therefore, we estimated the Alpha factor parameters of the emergency diesel generator (EDG) for Ulchin Unit 3 by using the International Common-Cause Failure data Exchange (ICDE) database. The ICDE database provides the member countries with only the information needed for an estimation of the CCF parameters. The Ulchin Unit A3, pressurized water reactor, has two onsite EDGs and one alternate AC (AAC) diesel generator. The onsite EDGs of Unit 3 and 4 and the AAC are manufactured by the same company, but they are designed differently. The estimation procedure of the Alpha factor used in this study follows the approach of the NUREG/CR-5485. Since we did not find any qualitative difference between the ...

Energy Technology Data Exchange (ETDEWEB)

Seven generic types of collectors, together with associated subsystems for electric power generation, were considered. The collectors can be classified into three categories: (1) two-axis tracking (with compound-curvature reflecting surfaces); (2) one-axis tracking (with single-curvature reflecting surfaces); and (3) nontracking (with low-concentration reflecting surfaces). All seven collectors were analyzed in conceptual system configurations with Rankine-cycle engines. In addition, two of the collectors were analyzed with Brayton-cycle engines, and one was analyzed with a Stirling-cycle engine. With these engine options, and the consideration of both thermal and electrical storage for the Brayton-cycle central receiver, 11 systems were formulated for analysis. Conceptual designs developed for the 11 systems were based on common assumptions of available technology in the 1990 to 2000 time frame. No attempt was made to perform a detailed optimization of each ...

Energy Technology Data Exchange (ETDEWEB)

A {lambda}gt11 cDNA library was constructed from poly(U)-Spharose-selected Entamoeba histolytica trophozoite RNA in order to clone and identify surface antigens. The library was screened with rabbit polyclonal anti-E. histolytica serum. A 700-base-pair cDNA insert was isolated and the nucleotide sequence was determined. The deduced amino acid sequence of the cDNA revealed a cysteine-rich protein. DNA hybridizations showed that the gene was specific to E. histolytica since the cDNA probe reacted with DNA from four axenic strains of E. histolytica but did not react with DNA from Entamoeba invadens, Acanthamoeba castellanii, or Trichomonas vaginalis. The insert was subcloned into the expression vector pGEX-1 and the protein was expressed as a fusion with the C terminus of glutathione S-transferase. Purified fusion protein was used to generate 22 monoclonal antibodies (mAbs) and a mouse polyclonal antiserum specific for the E. histolytica portion of the fusion protein. ...

Energy Technology Data Exchange (ETDEWEB)

Radioisotopes of Pb(II) have been of some interest in radioimmunotherapy and radioimmunoimaging (RII). However, the absence of a kinetically stable bifunctional chelating agent for Pb(II) has hampered its use for these applications. {sup 203}Pb (T{sub 1/2}=52.02 h) has application potential in RII, with a {gamma}-emission that is ideal for single photon emission computerized tomography, whereas {sup 212}Pb (T{sub 1/2}=10 h) is a source of highly cytotoxic {alpha}-particles via its decay to its {sup 212}Bi (T{sub 1/2}=60 min) daughter. The synthesis of the novel bifunctional chelating agent 2-(4-isothiocyanotobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoyl methyl)-cyclododecane (4-NCS-Bz-TCMC) is reported herein. The Pb[TCMC]{sup 2+} complex was less labile to metal ion release than Pb[DOTA]{sup 2-} at pH 3.5 and below in isotopic exchange experiments. In addition to increased stability to Pb{sup 2+} ion release at low pH, the bifunctional TCMC ligand was found to have many other ...

International Nuclear Information System (INIS)

The authors have used limited proteolysis of affinity-labeled estrogen receptors (ER), coupled with antireceptor antibody immunoreactivity, to assess structural features of ER and the relatedness of ER from MCF-7 human breast cancer and rat uterine cells. MCF-7 ER preparations covalently labeled with ["3H]tamoxifen aziridine (["3H]TAZ) were treated with trypsin (T), #alpha#-chymotrypsin (C), or Staphylococcus aureus V8 protease prior to electrophoresis on sodium dodecyl sulfate gels. Fluorography revealed a distinctive ladder of ER fragments containing TAZ for each protease generated from the M/sub r/ 66,000 ER. Immunoblot detection with the primate-specific antibody D75P3#gamma# revealed that all immunoreactive fragments corresponded to TAZ-labeled fragments but that some small TAZ-labeled fragments were no longer immunoreactive. In contrast, use of the antibody H222SP#gamma# revealed a correspondence between TAZ-labeled and immunoreactive fragments down to the smallest fragments ...

Science.gov (United States)

Multicellular tumor spheroids (MCTS) are three dimensional cell culture systems induced by suspension culture. MCTS are widely used in cancer research because of their similarity to solid tumors. CaSki cells are derived from a metastatic cervical cancer containing human papillomavirus 16 (HPV16). Cell death of CaSki cells in MCTS has been previously reported, and our model is used to better characterize the mechanisms of cell death of HPV16-positive keratinocytes. In this study, we found that apoptosis of CaSki cells was induced by suspension culture along with the formation of MCTS after 24 h of incubation. In suspended CaSki cells, monoclonal antibodies blocking E-cadherin function inhibited MCTS formation and suppressed suspension-induced apoptosis in a dose-dependent manner. Western blot for E-cadherin detected upregulation of the authentic 120 kDa band from MCTS of CaSki cells as well as a shorter 100 kDa band. Addition of EGF, whose receptor is known to form ...

International Nuclear Information System (INIS)

Radioimmunotherapy (RIT) is a new treatment option for patients with non-Hodgkin lymphoma (NHL). Response to RIT currently remains difficult to predict using conventional prognostic factors and could be refined using functional imaging. The goal of this work is to evaluate the value of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in predicting response to Yttrium 90-labeled monoclonal antibodies for patients with NHL. Thirty-five patients with NHL who had undergone 18F-FDG PET prior to RIT with either 90Y-ibritumomab tiuxetan (group A; n=17) or 90Y-epratuzumab tetraxetan (group B; n=18) were included in this retrospective study. Four functional criteria were determined for each tumour lesion in a given patient: maximum and mean standard uptake values (SUVmax and SUVmean), functional lesion volume (LVol) and total lesion glycolysis (TLG, product of the volume and the SUVmean). For each patient, we determined highest SUVmax and SUVmean, cumulative ...

International Nuclear Information System (INIS)

High liver uptake and slow body clearance presently limit the usefulness of "1"1"1In labeled antibodies for tumor imaging. We have investigated "2"0"3Pb as an alternate and better antibody label. The DTPA and cyclohexyl EDTA (CDTA) conjugates of an anticolon carcinoma antibody, 17-1A were labeled (bicyclic anhydride method) with "2"0"3Pb and "1"1"1In with 60 and 90% labeling yields, respectively. The biodistribution of "2"0"3Pb-17-1A conjugates was compared with the corresponding "1"1"1In-labeled preparations and with "2"0"3Pb-DTPA, "2"0"3Pb-nitrate and nonrelevant antibody controls in normal and human tumor (SW948) xenografted nude mice at 24, and 96 hr. Lead-203-labeled CDTA and DTPA antibody conjugates gave similar in vivo distributions. Even though the lead bound to these chelate-antibody conjugates was more labile in serum and in vivo, compared to indium, it cleared much faster from the liver and the whole body. A new series of chelating agents based on the incorporation of a ...

Energy Technology Data Exchange (ETDEWEB)

Anti-carcinoembryonic antigen monclonal antibody (MAb) CEA 102 was produced by immunization with purified CEA and the specific accumulation of radiolabeled CEA 102 in colorectal cancers was investigated by autoradiography of sugical specimens using Fuji Computed Radiography (FCR). Five patients with colorectal cancer were injected intravenously with {sup 131}I-labeled intact CEA 102 or its F(ab'){sub 2}. Primary tumor and liver metastases were successfully detected by external scanning with a gamma camera in 4 cases. Autoradiographic study of the surgical specimens using FCR showed predominant localization of {sup 131}I-labeled CEA 102 in primary tumors and liver metastases in all cases. Even a small liver metastasis (0.5 cm) was clearly visualized in the autoradiogram by FCR. The pixel distribution curves of the density of the respective tissues in the autoradiograms by FCR showed the heterogeneity of the distribution of administreted radiolabeled MAb in individual tumors, ...

Energy Technology Data Exchange (ETDEWEB)

The control problem associated to a class of horizontal-axis fixed-pitch variable-speed low-power wind energy conversion systems, working in the partial load region, consisting in the energy conversion maximization, is approached here under the assumption that the wind turbine model and its parameters are poorly known. Using a new approach derived from the optimum seeking methods category, generically called Maximum Power Point Tracking (MPPT), the proposed control solution aims at driving the average position of the operating point near to optimality. Instead of inducing sinusoidal search signals, the wind turbulence is here used as search disturbance. The high-speed shaft's average rotational speed is slowly adjusted using the Fast Fourier Transform processing of some available measures from the system as an estimate of the operating point's position/distance to optimality. Numerical simulations are used for preliminary checking the control law ...

Energy Technology Data Exchange (ETDEWEB)

We revisited the quantum Zeno paradox, which claims that a generic quantum system prepared in a state which is not an eigenstate of the Hamiltonian operator and is continuously observed never decays. Since any perfectly isolated quantum system always interact with a vacuum field, we analyze the possibility of using this fact to solve the above mentioned conceptual problem. Therefore we discuss a two-level system or qubit-Bose field interaction Hamiltonians. We consider the quantum dynamics of this two-level system, prepared in the excited state interacting with a Bose field prepared in the Poincare invariant vacuum state. Using a first-order approximation in time-dependent perturbation theory, we evaluate the probability of spontaneous decay of the two-level system driven by the vacuum field. This probability is evaluated for a finite time interval. Using the standard argument to obtain the quantum Zeno paradox, we consider N measurements where N {yields} ...

Energy Technology Data Exchange (ETDEWEB)

The Nuclear Regulatory Commission (NRC) is conducting an enhanced participatory rulemaking to establish radiological criteria for site cleanup and decommissioning of NRC-licensed facilities. Open public meetings were held during 1993 in Chicago, IL, San Francisco, CA, Boston, MA, Dallas, TX, Philadelphia, PA, Atlanta, GA, and Washington, DC. Interested parties were invited to provide input on the rulemaking issues before the NRC staff develops a draft proposed rule. This report summarizes 3,635 comments categorized from transcripts of the seven workshops and 1,677 comments from 100 NRC docketed letters from individuals and organizations. No analysis or response to the comments is included. The comments reflect a broad spectrum of viewpoints on the issues related to radiological criteria for site cleanup and decommissioning. The NRC also held public meetings on the scope of the Generic Environmental Impact Statement (GEIS) during July 1993. The GEIS meetings were ...

CERN Document Server

We study the Sunyaev-Zel'dovich (SZ) effect potentially generated by relativistic electrons injected from dark matter (DM) annihilation or decay in the Galaxy, and check whether it could be observed by Planck or ALMA, or even imprint the current CMB data as e.g. the specific fluctuation excess claimed from an recent re-analysis of the WMAP-5 data. We focus on high-latitude regions to avoid contamination of the Galactic astrophysical electron foreground, and consider the annihilation or decay coming from the smooth DM halo as well as from subhalos, further extending our analysis to a generic modeling of spikes arising around intermediate-mass-black-holes (IMBHs). We show that all these dark Galactic components are unlikely to produce any observable SZ effect. For a self-annihilating DM particle of 10 GeV with canonical properties, the largest optical depth we find is $\\tau_e \\lesssim 10^{-7}$ for massive isolated subhalos hosting IMBHs. We conclude that dark ...

Energy Technology Data Exchange (ETDEWEB)

This report is an overview of Pacific Northwest Laboratory's (PNL) research on how hydroelectric generation affects aquatic biota and environments. The major accomplishments of this research are described, and additional work needed to permit optimal use of available data is identified. The research goals are to: (1) identify impacts of hydroelectric generation, (2) provide guidance in allocating scarce water resources, and (3) develop techniques to avoid or reduce the impacts on aquatic communities or to compensate for unavoidable impacts. Through laboratory and field experiments, an understanding is being developed of the generic impacts of hydrogeneration. Because PNL is located near the Columbia River, which is extensively developed for hydroelectric generation, it is used as a natural laboratory for studying a large-scale operating system. Although the impacts studied result from a particular system of dams and operating procedures and occur within a ...

Energy Technology Data Exchange (ETDEWEB)

More than 30 environmental concerns were analyzed for the transportation of coal by rail, roads (trucks), high voltage transmission lines (that is, from mine-mouth generating plants to distribution networks), coal slurry pipelines, and barges. The following criteria were used to identify these problems: (1) real physical environmetal impacts for which control technologies must be developed, or regulation made effective where control technologies presently exist; (2) the level of impact is uncertain, although the potential impact may be moderate to high; (3) the concerns identified by the first two criteria are specific to or exacerbated by coal transportation. Generic transportation problems are not included. The significant environmental problems identified as a result of this study are: (1) rail transport - community traffic disruption and human health, safety, and habitat destruction; (2) coal haul roads - road degradation, traffic congestion and safety, air ...

International Nuclear Information System (INIS)

To facilitate potential cost savings in pipe whip protection design, TVA conducted a 1'' high pressure line break test to investigate the pipe whip behavior. The test results are available to EPRI as a data base for a generic study on nonlinear dynamic behavior of piping systems and pipe whip phenomena. This paper describes a nonlinear dynamic analysis of the TVA high energy line tests using ABAQUS-EPGEN code. The analysis considers the effects of large deformation and high strain rate on resisting moment and energy absorption capability of the analyzed piping system. The numerical results of impact forces, impact velocities, and reaction forces at pipe supports are compared to the TVA test data. The pipe whip impact time and forces have also been calculated per the current NRC guidelines and compared. The calculated pipe support reaction forces prior to impact have been found to be in good agreement with the TVA test data except for some peak values at the very ...

Energy Technology Data Exchange (ETDEWEB)

We study the condensation of localized closed string tachyons in C{sup 3}/Z{sub N} non-supersymmetric noncompact orbifold singularities via renormalization group flows that preserve supersymmetry in the worldsheet conformal field theory and their interrelations with the toric geometry of these orbifolds. We show that for worldsheet supersymmetric tachyons, the endpoint of tachyon condensation generically includes 'geometric' terminal singularities (orbifolds that do not have any marginal or relevant Kahler blowup modes) as well as singularities in co-dimension two. Some of the various possible distinct geometric resolutions are related by flip transitions. For Type II theories, we show that the residual singularities that arise under tachyon condensation in various classes of Type II theories also admit a Type II GSO projection. We further show that Type II orbifolds entirely devoid of marginal or relevant blowup modes (Kahler or otherwise) cannot ...

International Nuclear Information System (INIS)

A sum-over-histories generalized quantum theory is developed for homogeneous minisuperspace type A Bianchi cosmological models, focusing on the particular example of the classically recollapsing Bianchi type-IX universe. The decoherence functional for such universes is exhibited. We show how the probabilities of decoherent sets of alternative, coarse-grained histories of these model universes can be calculated. We consider in particular the probabilities for classical evolution defined by a suitable coarse graining. For a restricted class of initial conditions and coarse grainings we exhibit the approximate decoherence of alternative histories in which the universe behaves classically and those in which it does not. For these situations we show that the probability is near unity for the universe to recontract classically if it expands classically. We also determine the relative probabilities of quasiclassical trajectories for initial states of WKB form, recovering for such states a ...

Environmental Research Database

Objectives- Investigate the potential for the use of enzymes to bring about improvements in the recycling of recovered waste paper sources~%~~%~- Optimise enzyme formulations and process conditions to maximise benefits. - Produce recovered fibre at lower energy and chemical costs than is currently achievable using 'classical' de-inking techniques.~%~~%~- Improve recycled fibre quality and~%~~%~- All of the above will allow a greater use of recovered paper resources, which would otherwise be diposed of by [continued...]DescriptionThe project proposes to carry out an initial literature review to update the consortium on the currently available publications relating to the use of enzymes in de-inking.. This will be followed by an intensive laboratory study in an upgraded facility which will allow enzyme formulations and mechanisms to be studied. This work will also eliminate the need for an initial round of pilot plant ...

Science.gov (United States)

Large-scale invariant sets such as chaotic attractors undergo bifurcations as a parameter is varied. These bifurcations include sudden changes in the size and/or type of the set. An explosion is a bifurcation in which new recurrent points suddenly appear at a non-zero distance from any pre-existing recurrent points. We discuss the following. In a generic one-parameter family of dissipative invertible maps of the plane there are only four known mechanisms through which an explosion can occur: (1) a saddle-node bifurcation isolated from other recurrent points, (2) a saddle-node bifurcation embedded in the set of recurrent points, (3) outer homoclinic tangencies, and (4) outer heteroclinic tangencies. (The term ``outer tangency'' refers to a particular configuration of the stable and unstable manifolds at tangency.) In particular, we examine different types of tangencies of stable and unstable manifolds from orbits of pre-existing invariant sets. This leads to a ...

International Nuclear Information System (INIS)

A complete power plant design of a 1200-MWe ELMO Bumpy Torus Reactor (EBTR) is presented. An emphasis is placed on those features that are unique to the EBT confinement concept, with subsystems and balance-of-plant items that are more generic to magnetic fusion being adapted from past, more extensive tokamak reactor designs. Similar to the latter tokamak studies, this conceptual EBTR design also emphasizes the use of conventional or near state-of-the-art engineering technology and materials. An emphasis is also placed on system accessibility, reliability, and maintainability, as these crucial and desirable characteristics relate to the unique high-aspect-ratio configuration of EBTs. Equal and strong emphasis is given to physics, engineering/technology, and costing/economics components of this design effort. Parametric optimizations and sensitivity studies, using cost-of-electricity as an object function, are reported. Based on these results, the direction for ...

International Nuclear Information System (INIS)

Plasma surface interactions in tokamaks are known to create significant quantities of dust, which settles onto surfaces and accumulates in the vacuum vessel. In ITER, a loss of vacuum accident may result in the release of dust which will be radioactive and/or toxic, and provides increased surface area for chemical reactions or dust explosion. A new method of analysis has been developed for modeling dust resuspension and transport in loss of vacuum accidents. The aerosol dynamic equation is solved via the user defined scalar (UDS) capability in the commercial CFD code Fluent. Fluent solves up to 50 generic transport equations for user defined scalars, and allows customization of terms in these equations through user defined functions (UDF). This allows calculation of diffusion coefficients based on local flow properties, inclusion of body forces such as gravity and thermophoresis in the convection term, and user defined source terms. The code accurately reproduces ...

International Nuclear Information System (INIS)

The collision of the Earth with extra-terrestrial ice-volatile bodies is proposed as a mechanism to produce rapid changes in the geologic record. These bodies would be analogs of the ice satellites found for the Jovian planets and suspected for comets and certain low density bodies in the Asteroid belt. Five generic end-members are postulated: (1) water ice; (2) dry ice: carbon-carbon dioxide rich, (3) oceanic (chloride) ice; (4) sulfur-rich ice; (5) ammonia hydrate-rich ice; and (6) clathrate: methane-rich ice. Due to the volatile nature of these bodies, evidence for their impact with the Earth would be subtle and probably best reflected geochemically or in the fossil record. Actual boloids impacting the Earth may have a variable composition, generally some admixture with water ice. However for discussion purposes, only the effects of a dominant component will be treated. The general geological effects of such collisions, as a function of the dominant component ...

Energy Technology Data Exchange (ETDEWEB)

On February 1, 1984, the US Nuclear Regulatory Commission issued Generic Letter 84-04 on the subject of postulated pipe breaks in pressurized water reactor (PWR) primary coolant loops, opening the way for pipe-whip restraint exemptions. The letter substitutes the leak-before-break (LBB) criteria for the double-ended guillotine break regarding PWR primary reactor coolant system (RCS) piping and asymmetric blowdown loads. The LBB criterion refers to the fact that a piping flaw will leak before it breaks. The current requirement to provide pipe-whip restraints is applied within the plant to all high-energy piping with a potential for damaging structures, systems, and components essential to safe reactor shutdown. This includes primary RCS piping 30 in. and larger as well as smaller piping systems. A study was performed to evaluate the applicability of the LBB criteria proposed in NUREG-1061 to the latter set. The costs and benefits of this kind of application were ...

CERN Document Server

Probabilistic broadcast has been widely used as a flooding optimization mechanism to alleviate the effect of broadcast storm problem (BSP) in mobile ad hoc networks (MANETs). Many research studies have been carried-out to develop and evaluate the performance of this mechanism in an error-free (noiseless) environment. In reality, wireless communication channels in MANETs are an error-prone and suffer from high packet-loss due to presence of noise, i.e., noisy environment. In this paper, we propose a simulation model that can be used to evaluate the performance of probabilistic broadcast for flooding in noisy environment. In the proposed model, the noise-level is represented by a generic name, probability of reception (pc) (0<=pc<=1), where pc=1 for noiseless and <1 for noisy environment. The effect of noise is determined randomly by generating a random number \\zeta (0<=\\zeta<1); if \\zeta<=pc means the packet is successfully delivered to the ...

International Nuclear Information System (INIS)

Complete calculations of the accelerator related background in the muon spectrometer of the CMS detector at the Large Hadron Collider are presented. The simulations have been performed with the STRUCT multi-turn tracking code and the MARS and FLUKA cascade codes taking into account latest information of the LHC lattice, vacuum conditions, beam cleaning system and the shielding and layout of the CMS experiment. Beam loss distributions in the interaction regions and their vicinities and their contribution to the background levels in the muon spectrometer of CMS are analyzed. The studies show that hadronic and electromagnetic components of machine background are efficiently suppressed by the proposed CMS shielding. High energy muons penetrate through the shielding, but in positions of significance they do not contribute more than a few percent compared to the background generated by the pp-collisions. It is anticipated that the relative contribution of accelerator background will be ...

Energy Technology Data Exchange (ETDEWEB)

The onshore Potiguar basin has nowadays around 5.000 artificial lifting petroleum wells, distributed into 80 fields located on the states of Rio Grande do Norte and Ceara, representing approximately 8% of the national oil production. For that, well maintenance service, realized by Workover Rigs, is essential to preserve the oil productivity of the reservoirs on these fields. However, as the number of rigs is lower than to the number of wells needing maintenance, the task of administrating the management of such equipment according to the demand created by the wells, generates an optimization problem. The decision for a rig intervention on a well depends on parameters such as flow rate, depth, wasted time on intervention, distance from the rig to the next well, type of operation, rig capacity, environmental risks, etc. The objective of this paper is to present an interactive Computational System for Support Decision to the optimized management of the wells attended by the rig fleet. ...

International Nuclear Information System (INIS)

Purpose: To assess the prognostic value of biologic (p53, Ki-67) and clinical factors in squamous cell carcinoma of the oropharynx after radical surgery and postoperative radiotherapy (RT). Methods and Materials: Between 1985 and 1995, a total of 102 patients with 104 tumor sites were entered onto the study. Fifty-five primary tumors (53%) involved the tonsils, 26 (25%) the soft palate, and 23 (22%) the base of the tongue. Median age was 53 years (range 36-80 years). The clinical T- and N-categories (UICC 1997) were: T1 (30), T2 (47), T3 (22), T4 (5), N0 (33), N1 (28), N2 (42), and N3 (1). Histologically-clear margins were achieved in all patients by initial surgery. Postoperative RT to the primary and regional lymphatics was given, to a total of 60 Gy in 6 weeks, and single daily fractions of 2 Gy. The expression of the nuclear p53- and Ki-67-labeling index (LI) was investigated by immunostaining using the monoclonal antibodies DO-7 and MIB 1. The nuclear ...

International Nuclear Information System (INIS)

Eddy current testing (ECT) method is widely used as the non-destructive evaluation (NDE) of the various kinds of material degradation occurring in nuclear power plants (NPPs) components including steam generator (SG) tubes. Detection of any defects or flaws in the steam generator tubes in the early stage is very important in maintenance of NPP for its primary role as the pressure boundary with thin wall thickness. Although the ECT technique provides lots of information for a SG management, it has a generic problem in its reliability due to a low ability in detect of small defects and some difficulty in a signal analysis. For the improvement of these shortcomings in conventional ECT, profile-MRPC (motorized rotating pancake coil) ECT technology was developed in KAERI. The key of this new technology is the development of new eddy current probes, designated as a diagnostic probe (D-probe). The D-probe is furnished with a simultaneous dual function of a defect ...

International Nuclear Information System (INIS)

We revisit our original papers on the burst mode of accretion by incorporating a detailed energy balance equation into a thin-disk model for the formation and evolution of circumstellar disks around low-mass protostars. Our model includes the effect of radiative cooling, viscous and shock heating, and heating due to stellar and background irradiation. Following the collapse from the prestellar phase allows us to model the early embedded phase of disk formation and evolution. During this time, the disk is susceptible to fragmentation, depending upon the properties of the initial prestellar core. Globally, we find that higher initial core angular momentum and mass content favors more fragmentation, but higher levels of background radiation can moderate the tendency to fragment. A higher rate of mass infall onto the disk than that onto the star is a necessary but not a sufficient condition for disk fragmentation. More locally, both the Toomre Q-parameter needs to be below a critical value ...

Energy Technology Data Exchange (ETDEWEB)

When a plasma becomes contaminated by foreign particles, generically referred to as dust, the result is called a dusty plasma. At the present time there is a great deal of interest in dusty plasmas because of their roles in terrestrial and extra-terrestrial processes - semiconductor processing, high temperature fusion experiments, stellar formation and the rings of Saturn. This thesis is concerned with the role of dust in processing type plasmas. In the following experiments, artificial dust is introduced into a parallel electrode plasma chamber. Ions and electrons in the plasma charge the dust particles and they become suspended in the plasma due to the balancing of electric and gravitational forces. By illuminating the suspended dust with laser light and using an extremely high speed camera fitted with a macro lens to look at the scattered light, the dust particles are observed directly. Specially written computer software is then able to track and analyse the ...

International Nuclear Information System (INIS)

We evaluate the neutrino fluxes to be expected from neutralino lightest supersymmetric particle (LSP) annihilations inside the Sun, within the minimal supersymmetric extension of the standard model with supersymmetry-breaking scalar and gaugino masses constrained to be universal at the grand unified theory scale [the constrained minimal supersymmetric standard model (CMSSM)]. We find that there are large regions of typical CMSSM (m_1_/_2,m_0) planes where the LSP density inside the Sun is not in equilibrium, so that the annihilation rate may be far below the capture rate. We show that neutrino fluxes are dependent on the solar model at the 20% level, and adopt the AGSS09 model of Serenelli et al. for our detailed studies. We find that there are large regions of the CMSSM (m_1_/_2,m_0) planes where the capture rate is not dominated by spin-dependent LSP-proton scattering, e.g., at large m_1_/_2 along the CMSSM coannihilation strip. We calculate neutrino fluxes above various threshold ...

Energy Technology Data Exchange (ETDEWEB)

Aging degradation is a phenomenon we all experience throughout life, both on a personal basis and in business. Many industries have been successful in postponing the inevitable impact on their related systems and components through programs to maintain long-term reliability, maintainability and safety. However, this has not always been the case for nuclear power. While all power plants are experiencing the world trend of increasing operating costs with age, few (if any) have been able to fully define the parameters that solve the aging equation, particularly in relation to major components. Inspection and preventive maintenance have not been effective in predicting life-limiting degradation and failure. In CANDU nuclear plants, utilities are taking a comprehensive approach in dealing with the aging problem. Programs have been established to identify the current condition and degradation mechanisms of critical components, the failure of which would impact negatively on station ...

Energy Technology Data Exchange (ETDEWEB)

The increasing complexity of the real-time data acquisition and processing systems (TDAQ: the so called Trigger and Data AcQuisition systems) in high energy physics calls for an appropriate evolution of development tools. This work is about the interplay between in principle specifications of TDAQ systems and their actual design and realization on a concrete hardware and software platform. The basis of our work is to define a methodology for the development of TDAQ systems that meets the specific demands for the development of such systems. The result is the detailed specification of a 'methodological framework' based on the Unified Modeling Language (UML) and designed to manage a development process. The use of this UML-based methodological framework progressively leads to the setting up of a 'home-made' framework, i.e. a development tool that comprises reusable components and generic architectural elements adapted to TDAQ ...

International Nuclear Information System (INIS)

This paper describes the unique challenges involved in achieving compliance with the Resource Conservation and Recovery Act (Public Law 94-580) Land Disposal Restrictions (LDR) treatment standards for four types of mixed wastes generated throughout the U.S. Department of Energy (DOE) complex: (1) radioactively contaminated lead acid batteries; (2) radioactively contaminated cadmium-, mercury-, and silver-containing batteries; (3) mercury-bearing mixed wastes; and (4) radioactive lead solids. For each of these mixed waste types, the paper identifies the strategy pursued by DOE's Office of Pollution Prevention and Resource Conservation Policy and Guidance (EH-43) in coordination with other DOE elements and the U.S. Environmental Protection Agency (EPA) to meet the compliance challenge. Specifically, a regulatory interpretation was obtained from EPA agreeing that the LDR treatment standard for wastes in the D008 'Radioactive Lead Solids' sub-category applies to radioactively contaminated ...

International Nuclear Information System (INIS)

This is the 1st revision of the INIS/ETDE Joint Thesaurus. It contains 20 953 valid descriptors and 8 600 forbidden terms. It was last updated in December 2003. The Joint Thesaurus contains the controlled terminology for indexing all information within the subject scope of both INIS (International Nuclear Information System) and ETDE (Energy Technology Data Exchange) information systems. The terminology is intended for use in subject description for input or retrieval of information in those systems. The thesaurus is a terminological control device used in translating from the natural language of documents, indexers or users into a more constrained system language It is also a controlled and dynamic vocabulary of semantically and generically related terms which covers a specific domain of knowledge. The domain of knowledge covered by this Thesaurus includes physics (in particular, plasma physics, atomic and molecular physics, and especially nuclear and high-energy ...

Energy Technology Data Exchange (ETDEWEB)

Modern high-resolution electron microscopy (HREM) instruments, which are capable of a point-to-point resolution of better than 0.2 nm, have allowed atomic-scale observations of a variety of internal interfaces. The application of the HREM technique to fcc model systems for the purpose of addressing a number of interface issues will be examined in this paper. Atomic structure observations for heterophase interfaces of metal/metal and metal/metal-oxide systems as well as HREM studies of grain boundaries in NiO and Au will be discussed with emphasis on generic structural features and the role of the interface plane. Comparisons between observed interface structures and atomistic computer modeling results have shown agreements for some interfaces, as well as certain differences in others. A number of structural features are common to both metal and oxide grain boundaries, as well as certain heterophase boundaries. Of particular importance in close-packed solids appears ...

International Nuclear Information System (INIS)

This third tome about energy systems completes the two previous ones by showing up advanced thermodynamical cycles, in particular having a low environmental impact, and by dealing with two other questions linked with the study of systems with a changing regime operation: - the time management of energy, with the use of thermal and pneumatic storage systems and time simulation (schedule for instance) of systems (solar energy type in particular); - the technological dimensioning and non-nominal regime operation studies. Because this last topic is particularly complex, new functionalities have been implemented mainly by using the external classes mechanism, which allows the user to freely personalize his models. This tome is illustrated with about 50 examples of cycles modelled with Thermoptim software. Content: foreword; 1 - generic external classes; 2 - advanced gas turbine cycles; 3 - evaporation-concentration, mechanical steam compression, desalination, hot gas ...

Energy Technology Data Exchange (ETDEWEB)

This paper extends the analytical procedure described in another paper in these proceedings to analyze a variety of compact and light-weight OSC-designed radioisotope-heated generators. Those generators employed General Purpose Heat Source (GPHS) modules and a converter containing sixteen AMTEC cells of OSC`s revised five-tube design with enhanced cell wall reflectivity described in a companion paper in these proceedings. OSC found that the performance of the generator is primarily a function of the thermal insulation between the outside of the generator`s 16 cells and the inside of its wall. After examining a variety of insulation options, it was found that the generator`s performance is optimized by employing a hybrid insulation system, in which the space between the cells is filled with fibrous Min-K insulation, and the generator walls are lined with tapered (i.e., graded-length) multifoil insulation. The OSC design results in a very compact generator, with eight AMTEC cells on each ...

Energy Technology Data Exchange (ETDEWEB)

The sulfur-iodine (SI) thermochemical cycle is one of the main candidate methods to produce hydrogen from non-fossil sources like nuclear (GEN IV reactor) or solar thermal power. A major issue for the successful implementation of the SI cycle is the selection of technically viable and economic materials for construction of process components, particularly heat exchangers. Challenging conditions are encountered in each of the three sections of the SI cycle due to the corrosive chemicals present, including sulfuric acid, iodine, hydroiodic acid, sulfur dioxide, hydrogen, oxygen, and others. In Section I, aqueous, non-aqueous (liquid iodine), and gaseous multi-component phases are present at about 120 {sup o}C and 0.7 MPa. Section II involves gaseous and aqueous phases of sulfuric acid, sulfur dioxide, and oxygen at up to about 830 {sup o}C and 3.6 MPa. In Section III , aqueous, non-aqueous, and gaseous phases, at up to 310 {sup o}C and 2.2 MPa, containing iodine, hydroiodic acid, ...

Energy Technology Data Exchange (ETDEWEB)

This document presents a conceptual design for a contingency interim measure (IM) for treatment of the public water supply system at Barnes, Kansas, should this become necessary. The aquifer that serves the public water supply system at Barnes has been affected by trace to low concentrations of carbon tetrachloride and its degradation product, chloroform. Investigations conducted on behalf of the CCC/USDA by Argonne National Laboratory (Argonne 2008a) have demonstrated that groundwater at the Barnes site is contaminated with carbon tetrachloride at concentrations exceeding the Kansas Tier 2 risk-based screening level (RBSL) and the EPA maximum contaminant level (MCL) of 5.0 {micro}g/L for this compound. The Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) formerly operated a grain storage facility in Barnes, approximately 800 ft east-southeast of the public water supply wells. Carbon tetrachloride was used in the treatment of grain. Another potential source ...

Energy Technology Data Exchange (ETDEWEB)

In addition to the goal of ensuring waste disposal, thermal waste treatment has always been aimed at the energy-efficient utilisation of wastes. Developments in waste management have led to an increase in high-calorific waste arisings. This is attributable to the use of mechanical-biological waste treatment as well as to segregated waste collection systems. High-calorific wastes are equivalent to fossil fuels in terms of their calorific content. Furthermore, they fulfil the legal requirements for conversion to energy. Another source of high-calorific wastes suitable for conversion to energy can be made available through the segregated disposal of industrial wastes, in many cases at low cost. These high-calorific fractions of varying origin and composition are referred to generically as substitute fuels, a term which implies quality and availability by reference to other fuels. Specifically, the term substitute fuel implies that it can be used for energy production ...

Energy Technology Data Exchange (ETDEWEB)

We find that tachyonic orbifold examples of AdS/CFT have corresponding instabilities at small radius, and can decay to more generic gauge theories. We do this by computing a destabilizing Coleman-Weinberg effective potential for twisted operators of the corresponding quiver gauge theories, generalizing calculations of Tseytlin and Zarembo and interpreting them in terms of the large-N behavior of twisted-sector modes. The dynamically generated potential involves double-trace operators, which affect large-N correlators involving twisted fields but not those involving only untwisted fields, in line with large-N inheritance arguments. We point out a simple reason that no such small radius instability exists in gauge theories arising from freely acting orbifolds, which are tachyon-free at large radius. When an instability is present, twisted gauge theory operators with the quantum numbers of the large-radius tachyons acquire VEVs, leaving a gauge theory with fewer ...

International Nuclear Information System (INIS)

Full text: Full text: The incomplete understanding of the complex mechanisms connected with the interaction between thermal-hydraulic and neutron kinetics still challenges the design and the operation of nuclear reactors and imposes the adoption of conservatism in the evaluation of safety limits. The recent availability of powerful computer and computational techniques together with the continuing increase in operational experience suggests the revisiting of those areas and the identification of design/operation requirements that can be relaxed. So far, almost all of the safety analyses of research reactors have been performed using conservative computational tools such as channel codes but, nowadays, the application of Best-Estimate (BE) methods constitutes a real necessity. The global aim of the current work is an attempt to apply the best-estimate system thermal-hydraulic code Relap5. For this purpose, the generic IAEA research reactor Benchmark problem is ...

International Nuclear Information System (INIS)

Calibration-Free Laser-Induced Breakdown Spectroscopy (CF-LIBS) has been proposed several years ago as an approach for quantitative analysis of Laser-Induced Breakdown Spectroscopy spectra. Recently developed refinement of the spectral processing method is described in the present work. Accurate quantitative results have been demonstrated for several metallic alloys. However, the degree of accuracy that can be achieved with Calibration-Free Laser-Induced Breakdown Spectroscopy analysis of generic samples still needs to be thoroughly investigated. The authors have undertaken a systematic study of errors and biasing factors affecting the calculation in the Calibration-Free Laser-Induced Breakdown Spectroscopy spectra processing. These factors may be classified in three main groups: 1) experimental aberrations (intensity fluctuations and inaccuracy in the correction for spectral efficiency of a detection system), 2) inaccuracy in theoretical parameters used for ...

Energy Technology Data Exchange (ETDEWEB)

After several years of planning and workshop meetings, a decision was reached in late 2008 to organize PICMG xTCA for Physics Technical Subcommittees to extend the ATCA and MTCA telecom standards for enhanced system performance, availability and interoperability for physics controls and applications hardware and software. Since formation in May-June 2009, the Hardware Technical Subcommittee has developed a number of ATCA, ARTM, AMC, MTCA and RTM extensions to be completed in mid-to-late 2010. The Software Technical Subcommittee is developing guidelines to promote interoperability of modules designed by industry and laboratories, in particular focusing on middleware and generic application interfaces such as Standard Process Model, Standard Device Model and Standard Hardware API. The paper describes the prototype design work completed by the lab-industry partners to date, the timeline for hardware releases to PICMG for approval, and the status of the software ...

Energy Technology Data Exchange (ETDEWEB)

In the groundwater flow modelling part of this work the effective dilution volume in the well scenario was estimated by means of transient simulations of groundwater flow and transport, which are coupled due to the varying salinity. Both deep, drilled wells and shallow surface wells in the vicinity of the repository were considered. The simulations covered the time period from the present to 1000 years after the present. Conceptually the fractured bedrock consists of planar fracture zones (with a high fracture density and a greater ability to conduct water) and the intact rock (in which the fracture density and the hydraulic conductivity are low). For them the equivalent-continuum model was applied separately. Thus, the fractured bedrock was considered as piecewise homogeneous (except for the depth dependence) and isotropic continuum with representative average characteristics. A generic simulation model for groundwater flow and solute transport was developed on ...

International Nuclear Information System (INIS)

In summary, a scaling analysis of a water-cooled Reactor Cavity Cooling System (RCCS) system was performed based on generic information on the RCCS design of PBMR. The analysis demonstrates that the water-cooled RCCS can be simulated at the ANL NSTF facility at a prototypic scale in the lateral direction and about half scale in the vertical direction. Because, by necessity, the scaling is based on a number of approximations, and because no analytical information is available on the performance of a reference water-cooled RCCS, the scaling analysis presented here needs to be 'validated' by analysis of the steady state and transient performance of a reference water-cooled RCCS design. The analysis of the RCCS performance by CFD and system codes presents a number of challenges including: strong 3-D effects in the cavity and the RCCS tubes; simulation of turbulence in flows characterized by natural circulation, high Rayleigh numbers and low Reynolds numbers; validity ...