ulcerative colitis role: Topics by WorldWideScience.org

Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis.

The sequential events and the inflammatory mediators that characterize disease onset and progression of ulcerative colitis (UC) are not well known. In this study, we evaluated the early pathologic events...Full Text Available

2

The Role of Nutrition in the Etiology of Inflammatory Bowel Disease

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with a high incidence of colon cancer. Dysplasia is a precursor to carcinoma and a predictor of malignant potential; epithelia...Full Text Available

1994-02-01

3

British Library Electronic Table of Contents (United Kingdom)

Many foods have been implicated in theories about the etiology of inflammatory bowel disease. While evidence has accumulated that nutritional factors as part of overall lifestyle changes may play a role in the growing incidence, no specific dietary recommendations except the promotion of breastfeeding can currently be given to decrease the risk of developing Crohn's disease or ulcerative colitis. For the treatment of Crohn's disease in children and adolescents, however, enteral feeding with a semi-elemental diet seems to be as effective as corticosteroids in inducing and maintaining remission. In the meta-analyses, advantages of one formula over the other are evened out, and more research is warranted into the anti-inflammatory properties of different nutrients, such as polyunsaturated fat...

2011-01-01

4

Physiologic aspects of continence after colectomy, mucosal proctectomy, and endorectal ileo-anal anastomosis.

DNFB-DNS hapten-induced colitis in mice should not be considered a model of inflammatory bowel disease

We examined the physiology of continence in 12 patients at least four months after colectomy, mucosal proctectomy, and endorectal ileo-anal anastomosis for ulcerative colitis and familial polyposis....Full Text Available

1982-04-01

5

British Library Electronic Table of Contents (United Kingdom)

AbstractBackground: The dinitrofluorobenzene/dinitrosulfonic acid (DNFB/DNS) model was originally described as an experimental model of intestinal inflammation resembling human ulcerative colitis (UC). Due to the absence of acceptable UC experimental models for pharmacological preclinical assays, here we examine the immune response induced in this model. Methods: Balb/c mice were sensitized by skin application of DNFB on day 1, followed by an intrarectal challenge with DNS on day 5. We further expanded this model by administering a second DNS challenge on day 15. The features of colonic inflammation and immune response were evaluated. Results: The changes observed in colonic tissue corresponded, in comparison to the trinitrobenzene sulfonic acid (TNBS) colitis model, to a mild mucosal effe...

2011-01-01

6

Role of Intravenous Omeprazole in Patients with High-Risk Peptic Ulcer Bleeding After Successful Endoscopic Epinephrine Injection: A Prospective Randomized Comparative Trial

British Library Electronic Table of Contents (United Kingdom)

BACKGROUND: Epinephrine injection is the most common endoscopic therapy for peptic ulcer bleeding. Controversy exists concerning the optimal dose of proton pump inhibitors (PPI) for patients with bleeding peptic ulcers after successful endoscopic therapy. The objective of this study was to determine the optimal dose of PPI after successful endoscopic epinephrine injection in patients with bleeding peptic ulcers. METHODS: A total of 200 peptic ulcer patients with active bleeding or nonbleeding visible vessels (NBVV) who had obtained initial hemostasis with endoscopic injection of epinephrine were randomized to receive omeprazole 40 mg infusion every 6 h, omeprazole 40 mg infusion every 12 h or cimetidine (CIM) 400 mg infusion every 12 h. Outcomes were checked at 14 days after enrollment. RE...

2006-01-01

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Selective downregulation of retinoic acid-inducible gene I within the intestinal epithelial compartment in crohn's disease

British Library Electronic Table of Contents (United Kingdom)

AbstractBackground: A defective innate immune response may contribute to the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). Employing a global gene expression analysis, this study was aimed at identifying specifically regulated genes within the epithelial compartment in inflammatory bowel disease (IBD). Methods: The epithelial fraction of human ileal mucosa samples from surgical specimens was obtained by laser microdissection. Gene expression was examined by global expression profiling (n = 18, Affymetrix), quantitative reverse-transcription polymerase chain reaction (RT-PCR) (n = 35), immunoblot analysis (n = 9), and immunohistochemistry (n = 25). Results: Global expression profiling revealed a pronounced downregulation of the retinoic acid-inducible gene I (RIG-I) with...

2011-01-01

8

The role of autonomic neuropathy in diabetic foot ulceration.

Seasonal and Regional Dynamics of M. ulcerans Transmission in Environmental Context: Deciphering the Role of Water Bugs as Hosts and Vectors

Five standard, non-invasive tests of cardiovascular, autonomic function were performed in each of four groups of 30 subjects: controls, group 1, diabetics without clinical evidence of neuropathy; group...Full Text Available

1986-09-01

9

Interdisciplinary Mobility Team Approach To Reduction Of Facility-Acquired Pressure Ulcers

BackgroundBuruli ulcer, the third mycobacterial disease after tuberculosis and leprosy, is caused by the environmental mycobacterium M. ulcerans. Various modes of...Full Text Available

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The First Case of Antibiotic-associated Colitis by Clostridium difficile PCR Ribotype 027 in Korea

Pressure Ulcers

2011-03-29

11

Outbreak of acute colitis on a horse farm associated with tetracycline-contaminated sweet feed.

Clostridium difficile (C. difficile) is a common causative agent of pseudomembranous colitis (PMC). C. difficile-associated diarrhea (CDAD) ranges...Full Text Available

2009-06-01

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[A giant ulcer of the stomach with perforation into the liver simulating cancer].

Exposure of a group of horses to tetracycline-contaminated feed resulted in acute colitis and subsequent death in one horse and milder diarrhea in 3 others. The most severely affected animal demonstrated...Full Text Available

1999-10-01

13

Pectins from medicinal plants and their anti-ulcer activity

PMID:9163165

1996-01-01

14

No abstract prepared.

2008-07-01

15

Giant duodenal ulcers

Placebo effect in the treatment of duodenal ulcer

Giant duodenal ulcers (GDUs) are a subset of duodenal ulcers that have historically resulted in greater morbidity than usual duodenal ulcers. Until recently, few cases had been successfully treated...Full Text Available

2008-08-28

16

Laser Photobiomodulation of Wound Healing: A Review of Experimental Studies in Mouse and Rat Animal Models

AimsTo assess whether frequency of placebo administration is associated with duodenal ulcer healing.MethodsA systematic literature...Full Text Available

1999-12-01

17

British Library Electronic Table of Contents (United Kingdom)

Abstract Objectives: This investigation reviewed experimental studies of laser irradiation of wound healing in mice and rats published from 2003 to August 2008, respectively, to assess putative stimulatory effects of this treatment. Background: Animal models, including rodents, attempt to reflect human wound healing and associated problems such as dehiscence, ischemia, ulceration, infection, and scarring. They have played a key role in furthering understanding of underlying mechanisms involved in impaired wound healing, and in testing new therapeutic strategies including laser irradiation. Method: Original research papers investigating effects of laser or monochromatic light therapy on wound healing in mice and rats and published from January 2003 to August 2008 were retrieved from library...

2010-01-01

18

The direct comparison of health and ulcerated stomach tissue: A multiple probe microdialysis sampling approach

Intravenous proton pump inhibitors for peptic ulcer bleeding: Clinical benefits and limits

The ability to directly compare gastric ulcerated and healthy tissue would aid in the understanding of the physiological differences between these tissue types. Presently, these comparisons...Full Text Available

2008-09-10

19

Giant Lipoma of Posterior Neck with Bleeding Decubitus Ulcer: A Rare Entity

Peptic ulcer bleeding is a common disease and recurrent bleeding is an independent risk factor of mortality. Infusion with proton pump inhibitors (PPIs) prevents recurrent bleeding after successful...Full Text Available

2011-03-16

20

Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate?

Giant lipomas are benign soft tissue tumours. They are found relatively rarely on the posterior part of the neck. Bleeding pressure ulcer in this giant tumour is a rare presentation. Surgical interventions...Full Text Available

2010-05-01

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Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity

Cimetidine 1 g daily is often continued for a fixed period beyond the time of healing of duodenal ulcer on the assumption that it might reduce the subsequent relapse rate. To test this, 194 patients...Full Text Available

1982-02-27

22

Serum ferritin in recurrent oral ulceration

Maytenus ilicifolia Mart. ex Reissek is traditionally used in Brazil for treatment of gastric ulcers. Here we report the phytochemical investigation of an ethanol extract of M. ilicifolia leaves (EEMIL) aiming at the isolation of constituents which were used as chemical markers to monitor an activity-guided fractionation of a lyophilized aqueous extract of M. ilicifolia leaves (LAEMIL). From EEMIL, four flavonoids were isolated, namely the tri-flavonoid glycosides mauritianin (1), trifolin, (2) hyperin (4), and epi-catechin (5). Fractionation of LAEMIL led to 5 fractions which afforded the tetra-glycoside kaempferol derivative (3), and galactitol (6). LAEMIL and its fractions were evaluated in rats for their effects on gastric secretion volume and pH. HPLC (High Performance Liquid Chromatography) analysis revealed that only fractions containing the tri- and tetra-flavonoid glycosides 1 and 3 caused significant increase of gastric volume and pH, thus indicating that ...

23

Recurrent corneal ulceration in presence of synthetic microfibrils

A sensitive radio-assay for ferritin was developed and used to examine serum ferritin levels in 105 patients with recurrent oral ulceration (ROU), 41 patients with Behcet's syndrome (BS), 42 with other ulcerative oral lesions, 35 patients with non-ulcerative oral lesions and in 78 controls. Ferritin levels increased with age and were significantly higher in males than females. The mean ferritin concentrations in male patients with ROU, BS or with other oral ulcers were significantly reduced in comparison with controls, and in female patients were significantly reduced in those with major aphthous ulcers. The prevalence of low serum ferritin levels was about 8% in patients with ROU, 15% in BS and 9.5% in patients with other ulcerative oral lesions, compared with less than 3% in patients with non-ulcerative oral disorders and in ...

1983-01-01

24

Necrotizing sialometaplasia of tongue

Recurrence of microbial keratitis in the presence of protozoal infection is very rare and infrequently reported unless predisposing factors are present. The association of recurrent microbial keratitis...Full Text Available

2011-01-01

25

Necrotizing sialometaplasia, is a benign inflammatory lesion primarily involving the minor salivary glands of the hard palate. The lesion often presents itself as a deep-seated palatal ulcer with clinical...Full Text Available

2009-01-01

26

Critical Limb Ischemia

Instrument of millimetre wave radiation and its effect on malignant tumor in mice and its application in clinic

Opinion statementCritical limb ischemia (CLI), defined as chronic ischemic rest pain, ulcers, or gangrene attributable to objectively proven arterial occlusive disease, is the most advanced...Full Text Available

2010-06-01

27

Phaeoisaria clematidis as a Cause of Keratomycosis

An animated test is made for mice with malignant tumors irradiated by a self-made millimetre wave radiator for medical purpose. It is observed that S-180 sarcomas in mice after irradiation has been distinctly suppressed. And remarkable effects are shown through a lot of clinical practices on peptic ulcer, skin-deep ulcer, acute and chromic soft tissue injuries etc.

1995-12-31

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Partial Purification and Characterization of Biological Effects of a Lipid Toxin Produced by Mycobacterium ulcerans

We report the first case of human infection by Phaeoisaria clematidis. This fungus caused a corneal ulcer in a Brazilian man who had previously suffered an eye injury. Diagnosis was...Full Text Available

2000-06-01

29

Oxygen deprivation inhibits basal keratinocyte proliferation in a model of human skin and induces regio-specific changes in the distribution of epidermal adherens junction proteins, aquaporin-3, and glycogen

Organisms in the genus Mycobacterium cause a variety of human diseases. One member of the genus, M. ulcerans, causes a necrotizing skin disease called Buruli ulcer....Full Text Available

1998-02-01

30

Infected foot ulcers in male and female diabetic patients: a clinico-bioinformative study

It is generally accepted that hypoxia and recovery from oxygen deprivation contribute to the breakdown and ulceration of human skin. The effects of these stresses on proliferation, differentiation...Full Text Available

2009-01-01

31

Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis

BackgroundThe study aimed at (i) characterizing the mode of transmission of bla_CTX-Mand bla_TEM-1among extended-spectrum-β-lactamase...Full Text Available

32

Genomic Diversity and Evolution of Mycobacterium ulcerans Revealed by Next-Generation Sequencing

Chronic colonization of the human stomach by Helicobacter pylori, a Gram-negative bacterium, is the major cause of chronic gastritis, peptic ulcers and gastric cancer. Recent...Full Text Available

2010-05-01

33

Distribution Frequency of Pathogenic Bacteria Isolated from Cutaneus Leishmaniasis Lesions

Mycobacterium ulcerans is the causative agent of Buruli ulcer, the third most common mycobacterial disease after tuberculosis and leprosy. It is an emerging infectious disease that...Full Text Available

2009-09-01

34

Anti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) whole fruit ethanolic extract in laboratory animals

Cutaneous leishmaniasis (CL) is a parasitic disease characterized by single or multiple ulcerations. Secondary bacterial infections are one of the complications that can increase the tissue destruction...Full Text Available

2008-09-01

35

Tetracycline ulcers of the oesophagus

Background:The present study was undertaken to evaluate the anti-ulcer and antioxidant activities of the ethanol extract of Lagenaria breviflora (EELB)...Full Text Available

2011-01-01

36

Primary cutaneous Ewing's sarcoma/primitive neuroectodermal tumor manifesting numerous small and huge ulcerated masses: its complete remission by chemotherapy and magnetic resonance imaging findings

Two cases of tetracycline ulcers of the oesophagus are reported and compared with thirteen other cases from the literature. In most cases, the patients had taken their capsules with little or no fluid just before going to bed. Some hours later they developed retrosternal pain that was intensified by swallowing. Endoscopy showed sharply demarcated greyish-white areas of mucosal damage which represented layers of stratified squamous cells, separated by oedema, and a dense neutrophilic infiltration of the lamina propria and the muscularis mucosa. Roentgenology was unsuitable to detect the lesions. They healed without complications within one to six weeks. Prolonged retention of the capsules in the oesophagus is thought to cause the mucosal damage. Patients on oral tetracycline or doxycycline treatment should therefore be instructed to take their capsules with a meal or with copious water and not just before going to bed.

1981-11-01

37

Kundur [Benincasa hispida (Thunb.) Cogn.]: A potential source for valuable nutrients and functional foods

Extraskeletal Ewing's sarcoma (ES) and primitive neuroectodermal tumor (PNET) are widely regarded as clinically and histologically identical tumors which consist of small blue round cells. Extraskeletal ESs/PNETs usually occur in the deep soft tissues of the paraspinal region, chest wall, or lower extremities. However, superficially located cases, so-called cutaneous ESs/PNETs, are exceedingly rare, and the vast majority of the reported cases present as a single small mass. We present magnetic resonance imaging (MRI) findings and clinical course of a unique case of primary cutaneous ES/PNET presenting as numerous huge masses with severe ulceration on them. (orig.)

2010-06-01

38

British Library Electronic Table of Contents (United Kingdom)

Kundur [Benincasa hispida (Thunb.) Cogn.], a member of the family Cucurbitaceae, is one of the famous crops that are grown primarily for its fruits and usually recognized with its nutritional and medicinal properties especially in Asian countries. Kundur fruit has been valued as a nutritious vegetable as it provides a good source for natural sugars, amino acids, organic acids, mineral elements and vitamins. A number of medicinal properties such as anti-diarrheal, anti-obesity, anti-ulcer, and antioxidant and diuretic have been ascribed to this fruit of high economic value. As a rich source of functionally important bioactives and therapeutics such as triterpenes, phenolics, sterols, and glycosides, the fruit has been widely used for the treatment of epilepsy, ulcer, and other nervous disor...

2011-01-01

39

A prospective randomised open label study to evaluate the potential of a new silver alginate/carboxymethylcellulose antimicrobial wound dressing to promote wound healing

British Library Electronic Table of Contents (United Kingdom)

The aim of this study was to observe both the clinical signs and symptoms of wounds at risk of infection, that is critically colonised (biofilm infected) and antimicrobial-performance of an ionic silver alginate/carboxymethylcellulose (SACMC) dressing, in comparison with a non silver calcium alginate fibre (AF) dressing, on chronic venous leg and pressure ulcers. Thirty-six patients with venous or pressure ulcers, considered clinically to be critically colonised (biofilm infected), were randomly chosen to receive either an SACMC dressing or a non silver calcium AF dressing. The efficacy of each wound dressing was evaluated over a 4-week period. The primary study endpoints were prevention of infection and progression to wound healing. The SACMC group showed a statistically significant (P = ...

2010-01-01

40

Role-based access control

CERN Document Server

Role-based access control

2007-01-01

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41

Detection of abnormalities in febrile AIDS patients with In-111-labeled leukocyte and Ga-67 scintigraphy

Treatment of proliferative haemangiomas with the 585 nm pulsed dye laser.

Thirty-six patients with acquired immunodeficiency syndrome (AIDS), who were febrile but without localizing signs, underwent indium-111 leukocyte scintigraphy 24 hours after injection of labeled white blood cells (WBCs) and were restudied 48 hours after injection of gallium-67 citrate. Fifty-six abnormalities were identified as possible sources of the fever; 27 were confirmed with biopsy. Of these 27, 15 were identified only on In-111 WBC scans (including colitis, sinusitis, and focal bacterial pneumonia); six, only on Ga-67 scans (predominantly Pneumocystis carinii pneumonia and lymphadenopathy); and six, on both studies (predominantly pulmonary lesions). In-111 WBC scanning revealed 21 of 27 abnormalities (78%) and gallium scanning, 12 of 27 (44%). If only one scintigraphic study has been performed, particularly with Ga-67, a significant number of lesions would not have been detected. The authors believe radionuclide evaluation of the febrile AIDS patient without ...

42

Tissue-engineered product: allogeneic cultured dermal substitute composed of spongy collagen with fibroblasts.

Haemangiomas usually develop within the first few weeks of life, most regressing spontaneously before the age of 7 years. Some may ulcerate or compromise a vital function, in which case systemic corticosteroids, surgery or radiotherapy may be helpful. All of these treatment modalities are associated with significant morbidity. Treatment with the 585 nm flashlamp pulsed dye laser is safe and effective in the management of superficial vascular malformations. We report seven patients, under 12 months of age, who presented with proliferative haemangiomas, causing functional impairment. Ulcerated lesions were present in four patients. The patients were treated with the 585 nm pulsed dye laser (fluences 7.0-9.25 J/cm2), at intervals of 4-8 weeks. All of the lesions showed a significant reduction in size, together with improvement in the colour and integrity of the overlying skin. Treatment with the 585 nm pulsed dye laser should be considered in the ...

1996-04-01

43

Stereotactic body radiotherapy for unresectable cholangiocarcinoma

Recently, various types of allogeneic skin substitutes including cultured epidermal substitute (CES), cultured dermal substitute (CDS), and cultured skin substitute (CSS), which are composed of keratinocytes and/or fibroblasts as the cellular component(s), have been used as biological wound dressings. In our study, the allogeneic CDS was prepared by plating fibroblasts on a spongy collagen. The clinical evaluation was conducted using fresh or cryopreserved allogeneic CDS. In 145 of our clinical cases, 95% (138/145) of various wounds were evaluated as achieving good or excellent results, including 96% (22/23) of deep dermal burns (DDB) and dermal burns (DB), 100% (53/53) of partial-thickness donor wounds, 91% (21/23) of traumatic skin defects, 100% (5/5) of pressure ulcers, 82% (9/11) of chronic skin ulcers, 100% (6/6) of coverage for debrided DB, and 92% (22/24) of coverage for autologous meshed graft. The results obtained in our study suggest ...

2001-03-01

44

A prospective randomised open label study to evaluate the potential of a new silver alginate/carboxymethylcellulose antimicrobial wound dressing to promote wound healing.

Purpose: To report outcomes of a single institution study of stereotactic body radiotherapy (SBRT) for unresectable cholangiocarcinoma. The dose-volume dependency of the observed gastrointestinal toxicity is explored. Methods and materials: Twenty-seven patients with unresectable cholangiocarcinoma (n = 26 Klatskin tumours and one intrahepatic cholangiocarcinoma (IHCC)) were treated by linac-based SBRT. The dose schedule was 45 Gy in three fractions prescribed to the isocenter. Results: The median progression-free survival and overall survival were 6.7 and 10.6 months, respectively. With a median follow-up of 5.4 years, 6 patients had severe duodenal/pyloric ulceration and 3 patients developed duodenal stenosis. Duodenal radiation exposure was higher in patients developing moderate to high-grade gastrointestinal toxicity with the difference in mean maximum dose to 1 cm"3 of duodenum reaching statistical significance. A statistically significant association between ...

2010-01-01

45

Is there a role for financial investors in carbon markets?

The aim of this study was to observe both the clinical signs and symptoms of wounds at risk of infection, that is critically colonised (biofilm infected) and antimicrobial-performance of an ionic silver alginate/carboxymethylcellulose (SACMC) dressing, in comparison with a non silver calcium alginate fibre (AF) dressing, on chronic venous leg and pressure ulcers. Thirty-six patients with venous or pressure ulcers, considered clinically to be critically colonised (biofilm infected), were randomly chosen to receive either an SACMC dressing or a non silver calcium AF dressing. The efficacy of each wound dressing was evaluated over a 4-week period. The primary study endpoints were prevention of infection and progression to wound healing. The SACMC group showed a statistically significant (P = 0.017) improvement to healing as indicated by a reduction in the surface area of the wound, over the 4-week study period, compared with AF controls. In ...

2010-05-31

46

Opportunistic esophagitis in AIDS: Radiographic diagnosis

No abstract prepared.

2009-07-01

47

Is there a benefit to sentinel lymph node biopsy in patients with T4 melanoma?

Between 1983 and 1986, 35 of 90 patients with acquired immunodeficiency syndrome (AIDS) had double-contrast esophagograms to rule out opportunistic esophagitis. The radiographs were reviewed without knowledge of the clinical or endoscopic findings. Candida esophagitis was diagnosed radiographically in 17 patients who had varying degrees of plaque formation and viral esophagitis in three who had discrete ulcers without plaques. All three patients with viral esophagitis (herpes in 2 and cytomegalo virus in one) and 15 of 17 with Candida esophagitis had endoscopic and/or clinical corroboration of the radiographic diagnosis. Thus, the authors' experience suggests that fungal and viral esophagitis can often be differentiated on double-contrast esophagography, so that appropriate antifungal or antiviral therapy can be instituted without need for endoscopic intervention.

48

British Library Electronic Table of Contents (United Kingdom)

BACKGROUND: Controversy exists as to whether patients with thick (Breslow depth >4 mm), clinically lymph node-negative melanoma require sentinel lymph node (SLN) biopsy. The authors examined the impact of SLN biopsy on prognosis and outcome in this patient population. METHODS: A review of the authors institutional review board-approved melanoma database identified 293 patients with T4 melanoma who underwent surgical excision between 1998 and 2007. Patient demographics, histologic features, and outcome were recorded and analyzed. RESULTS: Of 227 T4 patients who had an SLN biopsy, 107 (47%) were positive. The strongest predictors of a positive SLN included angiolymphatic invasion, satellitosis, or ulceration of the primary tumor. Patients with a T4 melanoma and a negative SLN had a significa...

2009-01-01

49

Aluminium Phosphide-Induced Esophageal Stricture Palliation with Polyflex Stent

British Library Electronic Table of Contents (United Kingdom)

A 21-year-old woman developed midesophageal stricture two weeks after ingestion of aluminium phosphide (AlP) tablets. Aluminium phosphide is a lethal protoplasmic toxin and is also the most common cause of suicidal poisoning in northern India. Upper gastrointestinal endoscopy (UGIE) showed a tight esophageal stricture 29?cm from the incisors with a circumferential ulcer. Dilatation up to 17?mm was done using Savary-Gilliard dilators. She had repeated dilatations three times at nearly two-week intervals. In view of the resistant stricture, a silicone Polyflex stent was placed across the stricture and removed after 3?months; there was no recurrence of stricture even after three months of follow-up. Patients with recurrent esophageal stricture and those with fistula may benefit from silicone ...

2008-01-01

50

Tests for the diagnosis of Clostridium difficile infection: the next generation.

Results of electron beam therapy using intra-oral cone for carcinoma of the oral tongue

Clostridium difficile (C. difficile) causes 25-30% of cases of antibiotic associated diarrhea and most cases of pseudomembranous colitis. Patients presenting with diarrhea after hospitalization for 3 or more days should be tested for C. difficile. There are many options available for testing, each of which has inherent advantages and disadvantages. Most laboratories perform toxin testing using an enzyme immunoassay method. In general these tests have sensitivities ranging from 60 to 70% and specificities of 98%. When using these methods, symptomatic patients with negative tests should be tested by another more sensitive method. Until recently, cell culture cytotoxicity neutralization assays (CCNAs) were considered the gold standard in the U.S. A two-step algorithm using an EIA for glutamate dehydrogenase detection followed by testing positives using CCNA, offered an improved alternative until the availability of molecular assays. Although early studies that ...

2011-03-03

51

Cultured epidermal allografts as biological wound dressings.

Retrospective analyses were performed to evaluate the therapeutic efficacy of intra-oral cone (IOC) radiation therapy for carcinoma of the oral tongue, especially about its faculty of local control and complications. Thirty-nine patients with squamous cell carcinoma of the oral tongue were treated with IOC radiation therapy alone or in combination with external irradiation. IOC radiation therapy was given not only for T1 and T2, but also for T3 tumors. Hypofractionation was used for IOC radiation therapy. The 2 year local control rates, including surgical salvage, for T1, T2, T3 and T4 were 100%, 73.3%, 40% and 0%, respectively. The 5 year actuarial survival rates for Stage I, II, III and IV were 100%, 65.3%, 35.4% and 0%, respectively. The incidences of radiation complications, i.e. soft tissue ulceration and osteoradionecrosis, were 42.9% and 2.9%, respectively. It is suggested that relatively high rate of soft tissue ulceration was due to ...

1992-07-01

52

[Role of the radiohepatography and liver scanning in diagnosis of chronic alcoholic hepatitis].

Recent advances in cell culture technology permit the generation of large stratified epithelial sheets appropriate for wound coverage. Autografts (sheets prepared from the patient's own skin) have proven life-saving in the treatment of large third-degree burns and have been successfully employed in the management of chronic ulcers. Allografts (sheets prepared from the skin of an unrelated donor) have also been used. In our experience, cultured allografts derived from neonatal foreskin provide a potent stimulus to healing in a variety of partial thickness wounds. Their application is a simple outpatient procedure which involves no discomfort for the patient. In contrast to autografting, no biopsy is necessary and use of cultured allogenic cells permits immediate grafts availability and possibility of stockpiling and preserving grafts for future use. Preparation of epithelial sheets suitable for grafting is also faster and easier with newborn than with adult donor ...

1991-01-01

53

The role of maternal immunity for prevention of allergy in offspring

PMID:339527

1977-09-01

54

Norwegian Open Research Archives (NORA)

Full Text Available

55

Redefining the health information management privacy and security role.

Housing and capital accumulation : on the role of taxes

PMID:20052319

2009-09-16

56

Norwegian Open Research Archives (NORA)

Full Text Available

57

Complementary roles of PET and MR spectroscopy in the management of brain tumors

Transformation and Transition: DARPA's Role in Fostering an ...

Short communication.

1990-12-01

58

Role of organic acids in promoting colloidal transport of mercury from mine tailings

Transformation and Transition: DARPA's Role in Fostering an Emerging Revolution ... IDA Paper P-3698 Transformation and Transition: DARPA's ...

2003-11-01

59

CERN Document Server

Role of organic acids in promoting colloidal transport of mercury from mine tailings

2005-01-01

60

Recognizing Signposts: Anticipating the Future Role of the ...

Study on the stability of the Maytenus aquifolium Martius chemical components submitted to ionizing radiation (X-ray and #gamma#)

... The second section describes the role and functions of a corps as a joint task force headquarters and uses Operation Uphold Democracy ...

2011-05-19

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61

Severe rectal injury following radiation for prostatic cancer

The interest for medicinal plants has raised again in the last decades, after overcoming a declination period caused by the advances in the researches and development of the synthetic drugs industries. This growing interest has been stimulated mainly by searching cheap and accessible alternative therapies. However, in order to have natural products based treatment in an efficient and safety way, it is necessary to guarantee the plant authenticity, finding adulterations and to assure a low level of microbiological contaminations to avoid damages to consumer's health. The decontamination method should be chosen for eliminating or reduce the microorganisms level without loss of the plant active constituents that would destroy its therapeutic action. At the present work, the possibility of using #gamma# and X electromagnetic radiations to sterilize a Brazilian medicinal plant (Maytenus aquifolium Martius, Celastraceae), which shows anti-ulcer activity, was studied by ...

62

T lymphocytes in aortic and coronary intimas. Their potential role in atherogenesis.

Between 1970 and 1981, 348 patients underwent definitive irradiation. Of these patients 6 (1.7 per cent) sustained severe rectal injury as manifest by major rectal bleeding, rectal stricture, rectal mucosal slough and rectal ulceration. Severe rectal injury was observed in 0 of 13 patients (0 per cent) treated with 125iodine, 3 of 329 (1 per cent) treated with 6,400 to 6,800 rad external irradiation, 2 of 39 (5 per cent) treated with 7,000 to 7,300 rad external irradiation, and 1 of 7 (14 per cent) treated with 198gold and external irradiation. The impact of radiation dose, radiation therapy technique and surgical trauma was assessed. Rectal injury was managed by supportive measures in 2 patients and by diverting colostomy in 3 with benefit. One patient underwent abdominoperineal resection. A small bowel fistula and an intra-abdominal abscess developed, and the patient died.

1984-04-01

63

Role of mast cells in the pathogenesis of hypersensitivity pneumonitis.

In order to investigate the role of mononuclear cells in infiltrates during the initial stages of atherogenesis, the authors have studied by immunohistochemical methods the aortas and coronary vessels...Full Text Available

1988-02-01

64

Overall evaluation of training programmes and processes. Role of evaluation in the QA process

To examine the possibility that mast cells have a central role in the pathogenesis of hypersensitivity pneumonitis, 20 patients with this disease were studied with the aim of seeking evidence for mast...Full Text Available

1987-08-01

65

A Critical Reassessment of the Role of Mitochondria in Tumorigenesis

Different aspects of overall evaluation of training programmes and processes as well as role of evaluation in the quality assurance process are considered.

1994-03-21

66

The role of succinylcholine in the prevention of the obturator nerve reflex during transurethral resection of bladder tumors.

BackgroundMitochondrial DNA (mtDNA) is being analyzed by an increasing number of laboratories in order to investigate its potential role as an active marker of tumorigenesis...Full Text Available

2005-11-01

67

The Role of Opioid Receptor on the Analgesic Action of Intrathecal Sildenafil in Rats

PMID:18454211

2008-05-01

68

The Role of Na-Montmorillonite on Thermal Characteristics and Morphology of Electrospun PAN Nanofibers

Full Text Available

2007-06-01

69

Role of hormone and nutrition in radiation-induced rat mammary carcinogenesis

Full Text Available

2010-08-01

70

Role of congenital rubella reference laboratory: 21-months-surveillance in Liguria, Italy.

Published in summary form only.

71

Role of B2 Adrenergic Receptors in Labor Pain

PMID:20812517

2009-12-01

72

On the Asymmetrical Role of Intrinsic Defects in the Complementary/Opposing Oxide Formation/Dissolution Reactions.

Pain; Pain Threshold; Labour Pain

2010-10-01

73

Czech Academy of Sciences Repository

Full Text Available

1994-01-01

74

Obsidian under fire: considering the role of raw material variation in obsidian hydration analysis

Neutrino processes and pair formation in massive stars and supernovae.

No abstract prepared.

2000-07-01

75

NO Generation from Inorganic Nitrate and Nitrite: Role in Physiology, Nutrition and Therapeutics

Neutrino processes role in star evolution and onset of supernovae explosion

1964-01-01

76

Minimally Invasive Endoscopic Pituitary Surgery

Full Text Available

2009-08-01

77

Medline Plus

... There has been a role for placement of yttrium or radioactive phosphorous in a tumor called craniopharyngioma, ...

78

Further Evidence for the Role of Cantharidin in the Mating Behaviour of Blister Beetles (Coleoptera: Meloidae)

Formation and role of the community for water chemistry engineering in Japan

Full Text Available

2007-12-01

79

Distinct roles for dystroglycan, beta1 integrin and perlecan in cell surface laminin organization.

... 1343-3563 v. 57(1) SPECIFIC NUCLEAR REACTORS AND ASSOCIATED

2011-01-01

80

DEFF Research Database (Denmark)

Udgivelsesdato: 2001-Mar

2001-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

81

Climate Change: The Role of Particles and Gases

ScienceCinema

...global warming ...the effects of global warming ...also the ? that global warming ...

82

Transarterial Chemoembolization (TACE) for Inoperable Intrahepatic Cholangiocarcinoma

Peak "1"4CO_2 excretion, symptoms and eradication of H.Pylori (HP) in patients with duodenal ulcer (DU)

The aim of this retrospective study was to determine the safety and efficacy of chemoembolization (TACE) as palliative treatment for patients with unresectable intrahepatic cholangiocarcinoma (CCA) and to compare the results with those in the literature. Fifteen patients with histology-proven CCA (5 men, 10 women) had received palliative treatment with TACE over a 6-year period. The treatment protocol comprised repeated TACE at a minimum of 8-week intervals. TACE was performed with a mixture of 10 ml Lipiodol and 10 mg mitomycin C injected into the tumor-supplying vessels. Follow-up investigations after 8-10 weeks comprised contrast-enhanced multislice spiral CT and laboratory control. Statistical evaluation included survival analysis using the Kaplan-Meier method. During the investigation period 58 TACEs (3.9 #+-# 3.8; 1-15) were performed in 15 patients. Mean tumor size was 10.8 #+-# 4.6 cm (range, 2.0-18.0 cm). Unifocal tumor disease was diagnosed in eight patients, and multifocal ...

2007-11-01

83

Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby

Full text: Many factors including drug efficacy, compliance and antibiotic resistance may influence HP eradication rates. The "1"4C urea breath test is a sensitive method of confirming HP colonisation and eradication. The aim was to study the relationships between the peak "1"4CO_2 counts on the breath test prior to treatment, smoking and HP eradication, and to assess if persistent or recurrent symptoms implied failure of eradication. 117 patients with DU and HP colonisation proved on biopsy or rapid urease test who underwent "1"4C urea breath tests at least one month after eradication treatment was ceased were studied (69 male, 48 female, mean age 41, range 26-87 y). Questionnaire assessment of treatment regimen, smoking history and dyspeptic symptoms was made at the time of the breath test. A sub-group of 43 patients who had pre- and post-treatment breath tests was studied to assess if high peak "1"4CO_2 counts on the pre-treatment breath test related to treatment success. The mean ...

1997-12-01

84

Thermodynamic and structural analysis of microtubule assembly: the role of GTP hydrolysis.

BackgroundThe thymus plays a critical role in the development and maturation of T-cells. Humans have a single thoracic thymus and presence of a second thymus is considered an anomaly....Full Text Available

85

The role of the social worker in the accident and emergency department of a district general hospital

Different models have been proposed that link the tubulin heterodimer nucleotide content and the role of GTP hydrolysis with microtubule assembly and dynamics. Here we compare the thermodynamics of...Full Text Available

1997-03-01

86

The Role of an Online Community for People With a Rare Disease: Content Analysis of Messages Posted on a Primary Biliary Cirrhosis Mailinglist

This is a retrospective study of the development of the social worker role within the multi-disciplinary team setting of the Accident and Emergency (A&E) Department at Burnley General Hospital...Full Text Available

1994-03-01

87

The Medical Library Association: promoting new roles for health information professionals

BackgroundThis study focuses on the role of an Internet-based group for people who have an autoimmune liver disease, primary biliary cirrhosis. Primary biliary...Full Text Available

88

Species-specific microRNA roles elucidated following astrocyte activation

As the Medical Library Association (MLA) enters its second century, its role in providing leadership and focus for the education of health information professionals in a changing environment will be...Full Text Available

2002-01-01

89

Roles of curli, cellulose and BapA in Salmonella biofilm morphology studied by atomic force microscopy

MicroRNAs (miRNAs) are short non-coding RNAs that play a central role in regulation of gene expression by binding to target genes. Many miRNAs were associated with the function of the central nervous...Full Text Available

2011-05-01

90

Roles of (Z)-3-hexenol in plant-insect interactions

BackgroundCurli, cellulose and the cell surface protein BapA are matrix components in Salmonella biofilms. In this study we have investigated the roles of these...Full Text Available

91

Role-Reversal Exercise with Deaf Strong Hospital to Teach Communication Competency and Cultural Awareness

Green leaf C6-volatiles are among the most important herbivore-induced plant volatiles (HIPVs). They play important roles in mediating the behavior of herbivores and their natural enemies, and in triggering...Full Text Available

2011-03-01

92

Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin.

ObjectiveTo implement a role-reversal exercise to increase first-year pharmacy students' awareness of communication barriers in the health care setting, especially for deaf and hard-of-hearing...Full Text Available

2011-04-11

93

Role of plasma membrane calcium ATPase 2 in spinal cord pathology

To investigate the role of thyroxine-binding globulin (TBG) and albumin in the availability of thyroid hormones to peripheral tissues, comprehensive kinetic studies of thyroxine (T4) and triiodothyronine...Full Text Available

1987-08-01

94

Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease

A number of studies have indicated that plasma membrane calcium ATPases (PMCAs) are expressed in the brain and spinal cord and could play important roles not only in the maintenance of cellular calcium...Full Text Available

2010-05-26

95

Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth

Accumulated lines of evidence suggest that hyperimmune responses to periodontal bacteria result in the destruction of periodontal connective tissue and alveolar bone. The etiological roles of periodontal...Full Text Available

96

Role of IgG and complement component C5 in the initial course of experimental cryptococcosis.

MicroRNAs (miRs) can regulate many cellular functions, but their roles in regulating responses of vascular endothelial cells (ECs) to mechanical stimuli remain unexplored. We hypothesize that the physiological...Full Text Available

2010-02-16

97

Role of Group A Streptococcal Virulence Factors in Adherence to Keratinocytes

Although cellular immunity has a crucial role during cryptococcosis, several in vitro studies have pointed out the importance of IgG anti-Cryptococcus neoformans antibodies and complement components...Full Text Available

1989-12-01

98

Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

To evaluate the role of putative group A streptococcal virulence factors in the initiation of skin infections, we compared the adherence of a wild-type M49-protein skin-associated strain to that of...Full Text Available

2000-03-01

99

Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2

The secreted Bv8 protein has been recently characterized as a regulator of myeloid cell mobilization and a neutrophil-derived mediator of tumor angiogenesis in several xenografts, but its role in tumor...Full Text Available

2008-02-19

100

Presence of preactivated T cells in hemodialyzed patients: their possible role in altered immunity.

BackgroundThe lactogenic hormones prolactin (PRL) and placental lactogens (PL) play central roles in reproduction and mammary development. Their actions are mediated via binding...Full Text Available

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101

Masculine Gender Roles Associated with Increased Sexual Risk and Intimate Partner Violence Perpetration among Young Adult Men

Interleukin 2 (IL-2) and B-cell growth factors I and II (BCGF I and BCGF II) are lymphokines produced by T cells that play a major role in T- and B-cell cooperation. Peripheral blood lymphocytes from...Full Text Available

1986-10-01

102

Hsp12.6 Expression Is Inducible by Host Immunity in Adult Worms of the Parasitic Nematode Nippostrongylus brasiliensis

This study sought to assess the association between traditional masculine gender role ideologies and sexual risk and intimate partner violence (IPV) perpetration behaviors in young men's heterosexual...Full Text Available

2006-07-01

103

Genome-Wide Analysis Reveals a Major Role in Cell Fate Maintenance and an Unexpected Role in Endoreduplication for the Drosophila FoxA Gene Fork Head

Heat shock proteins (Hsp) are a family of stress-inducible molecular chaperones that play multiple roles in a wide variety of animals. However, the roles of Hsps in parasitic nematodes remain largely...Full Text Available

104

Gene-silencing reveals the functional significance of pheromone biosynthesis activating neuropeptide receptor (PBAN-R) in a male moth

Transcription factors drive organogenesis, from the initiation of cell fate decisions to the maintenance and implementation of these decisions. The Drosophila embryonic salivary gland...Full Text Available

105

Effects of job rotation and role stress among nurses on job satisfaction and organizational commitment

The role of pheromone biosynthesis activating neuropeptide (PBAN) in the regulation of pheromone biosynthesis of several female moth species is well elucidated, but its role in the males has been a...Full Text Available

2010-09-28

106

Critical role of SDF-1?-induced progenitor cell recruitment and macrophage VEGF production in the experimental corneal neovascularization

BackgroundThe motivation for this study was to investigate how role stress among nurses could affect their job satisfaction and organizational commitment, and whether the job rotation...Full Text Available

107

Betaxanthins as Substrates for Tyrosinase. An Approach to the Role of Tyrosinase in the Biosynthetic Pathway of Betalains1

PurposeTo address the roles of the stromal derived factor-1 (SDF-1) α in the course of experimental corneal neovascularization (CNV).MethodsCNV...Full Text Available

108

The protein truncation caused by fusion of PEP-1 peptide and protective roles of transduced PEP-1-MsrA in skin cells

Tyrosinase or polyphenol oxidase (EC 1.14.18.1) is the key enzyme in melanin biosynthesis and in the enzymatic browning of fruits and vegetables. The role of tyrosinase in the secondary metabolism of...Full Text Available

2005-05-01

109

The Sustainment Management Support Project

Full Text Available

2011-04-01

110

The Effects of Needs for Affiliation and Needs for Self-Presentation on Digital Item Purchase Intention: The Moderating Roles of Gender and Purchase Experience

... due to the evolving nature of the Strategy Maps and the changing priority roles, it was decided not to link the SMSP directly with any Strategic Plans. ...

2010-09-01

111

Role of the #DELTA#(1232)-resonance at the systematic reduction of magnetic isovector transitions

Full Text Available

2008-09-01

112

Regulation of the expression of the apolipoprotein(a) gene : Evidence for a regulatory role of the 5' distal ACR enhancer in YAC transgenic mice

... electron reactions electrons excitation inelastic scattering m1-transitions proton

113

National Ignition Facility Management Descriptions Revision 4

No abstract prepared.

2003-01-30

114

Lessons from the past and prospects for the future

The purpose of this document is to describe the NIF Project Organization and the roles and responsibilities of the managers charged with executing the Project.

2000-08-01

115

Interaction Of Human La Protein With The Internal Ribosome Entry Site Of Hepatitis C Virus : Functional Role In Mediating Internal Initiation Of Translation

The author presents his impressions of the conference - that is - major lessons as presented in the talks on nonlinearities and their role in condensed matter physics. (WRF)

1986-05-04

116

Indian Institute of Science Theses & Dissertations (India)

Full Text Available

2004-07-01

117

Information Technology (IT) Management: The Clinger-Cohen ...

... Information Technology (IT) Management: ... The role of information technology figures prominently in the Homeland Security Act of 2002. ...

2005-02-03

118

Forging Space Warriors

Army Symposium: 'Leadership Challenges of the 21st Century ...

... These three roles are critical to de- fending the Nation through the control Milstar satellite on Titan IV at Cape Canaveral. ...

2011-05-15

119

Explicit representations of problem-solving strategies to support knowledge acquisition

... or the Noncommissioned Officer Efficiency Report (NCOER) for promotion ... Providing effective coaching, delegating, counseling, and role modeling ...

1996-05-01

120

The behavioral management of pain: a criticism of a response.

Role-limiting approaches support knowledge acquisition (KA) by centering knowledge base construction on common types of tasks or domain-independent problem-solving strategies. Within a particular problem-solving strategy, domain-dependent knowledge plays specific roles. A KA tool then helps a user to fill these roles. Although role-limiting approaches are useful for guiding KA, they are limited because they only support users in filling knowledge roles that have been built in by the designers of the KA system. EXPECT takes a different approach to KA by representing problem-solving knowledge explicitly, and deriving from the current knowledge base the knowledge gaps that must be resolved by the user during KA. This paper contrasts role-limiting approaches and EXPECT`s approach, using the propose-and-revise strategy as an example. EXPECT not only supports users in ...

1996-12-31

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121

Role of corporate memory in the global supply chain environment

In response to an earlier published paper by Fordyce, some assumptions underlying the behavior management paradigm of chronic pain are critically discussed. While operant treatment has proved successful, the conclusion that operant factors play an important role in the development and maintenance of chronic benign pain is debated. Some empirical studies, regularly used to demonstrate this role, are re-evaluated. An alternative theory is proposed for chronic pain behavior, in which the role of a lower tolerance to proprioceptive stimuli, which may include more than just pain stimuli, is emphasized. PMID:3313200

1987-09-01

122

British Library Electronic Table of Contents (United Kingdom)

Critical knowledge is proliferated among different knowledge owners of a corporate system through the individuals lying inside or outside the system. Extraction of such knowledge is a very crucial requirement for all organisations. This paper presents the role of critical knowledge in the proper functioning of a system by representing it in the form of eXtensible Markup Language to develop a corporate memory. In order to demonstrate the role of corporate memory in the organisation, a real-world problem of a global supply chain is considered. The problem utilises the concept of corporate memory for the selection of potential suppliers from a set of available suppliers, and further to select the best route from a set of available alternative routes. The objective deals with the minimisation ...

2009-01-01

123

Probable role of trace elements of some medicinal plants in cardio-vascular diseases

Nutrition and Physical Activity in Aging, Obesity, and Cancer

A number of herbal drugs are used in the Unani (Greco-Arab) System of Medicine for cardiovascular diseases. The herbs were analyzed by flame AAS and ICP-AES to determine if their therapeutic actions can be associated with the elements present in them. Cadmium, cobalt, chromium, copper, iron, potassium, magnesium, manganese, sodium, nickel, phosphorus, lead and zinc were some of the elements which play various roles in cardiovascular affections. An effort was made to correlate the role of these elements in cardiac diseases. (Auth.). 2 tabs., 32 refs.

124

British Library Electronic Table of Contents (United Kingdom)

The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH-STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH-STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH-STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.

2011-01-01

125

X-ray Emission as a Probe of the Wind-Driven Shock in WR 140

Vitamin D and respiratory health

single star evolution. To understand the evolution of massive stars and their role in shaping the galaxy, understanding of the distribution of ...

126

Vitamin D and Serum Cytokines in a Randomized Clinical Trial

Vitamin D is now known to be of physiological importance outside of bone health and calcium homeostasis, and there is mounting evidence that it plays a beneficial role in the prevention and/or treatment...Full Text Available

2009-10-01

127

Viruses and thyroiditis: an update

Background. The role of vitamin D in the body's ability to fight influenza and URI's may be dependent on regulation of specific cytokines that participate in the host inflammatory...Full Text Available

2010-01-01

128

Traditional Medicine in Oman: Its Role in Ophthalmology

Viral infections are frequently cited as a major environmental factor involved in subacute thyroiditis and autoimmune thyroid diseases This review examines the data related to the role of viruses in...Full Text Available

129

The role of information technologies in development of new conceptions of crystal chemistry

Aim:To present three patients with ocular disease who developed a range of complications following use of traditional medications.Settings...Full Text Available

2009-04-01

130

The role of fatty acid desaturases in epidermal metabolism

Russian Oct 2009 p. 130-131 Tajikistan Safiev, KI Saidov, P.Kh. Bozorov,

2009-10-01

131

The role of contagious disease in udder health

The lipid composition of skin is important to a variety of functions served by this organ. Therefore, skin expresses multiple enzymes that synthesize and metabolize lipids. An important class of lipid...Full Text Available

2011-04-01

132

The multiple roles of autophagy in cancer

Contagious diseases are a threat to animal health and productivity, both nationally and at the farm level. This makes implementation of biosecurity measures to prevent their introduction and...Full Text Available

2009-10-01

133

The Role of Military Workingn> Dogs in Low Intensity Conflict

Autophagy is an evolutionarily conserved, catabolic process that involves the entrapment of cytoplasmic components within characteristic vesicles for their delivery to and degradation within lysosomes....Full Text Available

2011-07-01

134

The Basics of Global Warming - Fight Global Warming - Environmental Defense Fund

... 8 Page 15. Military working Dogs. Dogs that are required by the using DOD Component for a specific purpose, mission, or combat capability. ...

1990-02-01

135

Teaching Secure Programming

Information about the greenhouse effect, the role of greenhouse gases in global climate change, levels of greenhouse gases in the atmosphere, and references....

136

Stars, their evolution and their stability

This article discusses issues in teaching secure coding in the context of both academic institutions and training organizations. The emphasis is on the importance of assurance. There is also some discussion of the role of checklists.

2005-09-01

137

Solution structure and dynamics of sugarcane defensin 5: the role of dynamics in the interaction with lipid membranes

The Nobel lecture of Chandrasekhar is printed in which he describes the basic processes that determine the life history of a star with particular emphasis on the roles of stellar mass and radiation pressure. (AIP)

1984-04-01

138

Site-Specific Methylation of the Promoter Alters Deoxyribonucleic Acid-Protein Interactions and Prevents ...

English 2009 p. 161-162 Brazil Paula, Viviane Silva de Almeida, Fabio

2009-05-04

139

Roles of ER, Src-1, and CBP Phosphorylation in Estrogen ...

... and R. L. Momparler. DNA methylation of retinoic acid receptor beta in breast cancer and possible therapeutic role of ... ...

140

Role of the 5HT3 Receptor in Alcohol Drinking and ...

... from a mouse carcinogen-induced mammary gland tumor model indicated that it is overexpressed in 12 out of 13 tumors ...

1998-06-01

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141

Role of spinal cyclooxygenase in human postoperative and chronic pain

... Proc Natl Acad Sci USA 97:11032-7 27. Duman RS 2002 Genetics of childhood disorders: XXXIX. Stem cell research, part 3: ...

2005-09-01

142

Role of Positron Emission Mammography (PEM) Flex Solo II Positron Emission Tomography (PET) Scanner in Evaluating Neoadjuvant Chemotherapy Response in Patients With Breast Cancer

BackgroundNonsteroidal anti-inflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest these drugs act in part by blocking...Full Text Available

2010-05-01

143

Role of Orvosi Hetilap in the development of Hungarian gastroenterology

Breast Cancer

2011-06-14

144

Role of Obesity in Prostate Cancer Development

AIM: To analyze the contribution of Orvosi Hetilap (Hungarian Medical Journal) to the field of gastroenterology.METHODS: All issues of the journal between 1857 and 2008 and identified...Full Text Available

2010-05-14

145

Role of MeV ion implantation in limiting transient enhanced diffusion of boron atoms in silicon

... estrogen receptor status. Cancer Lett., 253, 291-300. 39. Xin,X ... and resistant mice. Brain Res.Bull., 52, 235-242. 40. Foster,BA ...

2011-04-01

146

Role of Mast Cells in Early and Delayed Radiation Injury in Rat Intestine

English Jul 2001 p. 143-144 China Liu Changlong Academia Sinica,

2001-07-01

147

Relationship of source and sink in determining kernel composition of maize

... mast cell staining; ref. 16). The severity of structural radiation injury was assessed using a histopathological radiation injury score ... ...

148

Regulatory T cells in human disease and their potential for therapeutic manipulation

The relative role of the maternal source and the filial sink in controlling the composition of maize (Zea mays L.) kernels is unclear and may be influenced by the genotype and the N...Full Text Available

2010-01-01

149

Read Code Quality Assurance

Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory...Full Text Available

2006-05-01

150

Orbital lymphoma: Role of radiation

As controlled clinical vocabularies assume an increasing role in modern clinical information systems, so the issue of their quality demands greater attention. In order to meet the resulting stringent...Full Text Available

1998-07-01

151

Nutating Mechanical Transmission (Maroth Drive Principle)

The purpose of this article is to review the literature for clinical presentation, treatment, outcome and complications of using radiotherapy for the treatment of orbital lymphoma. For this, MEDLINE,...Full Text Available

2009-03-01

152

Nascent Aneurysm Formation at the Basilar Terminus Induced by Hemodynamics

... d Diameter of ro.'ling element of a cylindrical roller bearing ... L Life (B-10) of a cyl.ndrical roller bearing LACA Contact ratio ...

1974-01-01

153

NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 10: The NASA/DOD Aerospace Knowledge Diffusion Research Project

Background and PurposeHemodynamic insults at arterial bifurcations are hypothesized to play a key role in intracranial aneurysm formation. This study investigates...Full Text Available

2008-07-01

154

Metals and kidney autoimmunity.

The role of the NASA/DOD Aerospace Knowledge DIffusion Research Project in helping to maintain U.S.

1991-01-01

155

MYELIN, COPPER, AND THE CUPRIZONE MODEL OF SCHIZOPHRENIA

The causes of autoimmune responses leading to human kidney pathology remain unknown. However, environmental agents such as microorganisms and/or xenobiotics are good candidates for that role. Metals,...Full Text Available

1999-10-01

156

Lens-induced glaucoma in the elderly

In recent years increasing evidence is pointing toward white matter abnormalities in schizophrenia and other psychiatric disorders. The present paper will provide an overview over the role of...Full Text Available

157

Kitasato symposium 2010: new prospects for cytokines

Lens-induced glaucoma comprises a number of different glaucomatous processes occurring in the elderly that share in common the role of the crystalline lens in the mechanism of increase in intraocular...Full Text Available

2009-01-01

158

Iron Therapy for Preterm Infants

The Second Kitasato Symposium: New Prospects for Cytokines brought together researchers and rheumatologists to consider the essential role of cytokines in health and their contributions to autoimmunity....Full Text Available

2010-01-01

159

Inverse Scattering and Applications. Proceedings of ...

SYNOPSISPreterm infants are at risk for both iron deficiency and iron overload. The role of iron in multiple organ functions suggests that iron supplementation is essential for...Full Text Available

2009-03-01

160

Informational Element of Power: The Role of Public Diplomacy ...

... Richrd Bals andLina PrissJames Lepowsky and Mirko Primc Richard Beaals, and Linda Preiss Rothschild, Editors 47 Linear algebra and its role in ...

2011-05-14

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161

Imbibition of Swietenia macrophylla (Meliaceae) Seeds: The Role of Stomata

... 26 Department of National Security and Strategy, Elements of National Power Model or MID-LIFE Model, US Army War College, 2004. 27 Ibid. ...

2005-03-18

162

Identification of Contractile Vacuole Proteins in Trypanosoma cruzi

• Background and Aims The occurrence of stomata in seed coats is uncommon and there is limited information about their function(s). The aim of this study was to verify the distribution...Full Text Available

2006-07-01

163

Healthy aging and disease: role for telomere biology?

Contractile vacuole complexes are critical components of cell volume regulation and have been shown to have other functional roles in several free-living protists....Full Text Available

164

Environmental chemical-induced macrophage dysfunction.

Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease,...Full Text Available

2011-05-01

165

Distinct sensory representations of wind and near-field sound in the Drosophila brain

Immunomodulation by environmental chemical contaminants and the role immune parameters play in toxicity and risk assessment studies is of increasing concern. Although considerable evidence has indicated...Full Text Available

1981-06-01

166

Deforestation Plays Critical Climate Change Role - NASA Earth ...

Behavioral responses to wind are thought to play a critical role in controlling the dispersal and population genetics of wild Drosophila species1,Full Text Available

2009-03-12

167

Current Projects - Human Nutrition Research Center on Aging ...

May 11, 2007 ... "Deforestation in the tropics accounts for nearly 20 per cent of carbon emissions due to human activities," Dr. Canadell says. ...

168

Cancer cells cause vascular endothelial cell (vEC) retraction via 12(S)HETE secretion; the possible role of cancer cell derived microparticle.

diet and genetic obesity metabolic defects and inflammation. To determine the role of adipocyte death in promoting adipose tissue inflammation and insulin resistance in animal...

2011-08-31

169

PMID:17103063

2006-11-12

170

CURRICULUM VITAE

CERN scientists confront data deluge

... 84. Fields BS, Haupt T, Davis JP, Arduino MJ, Butler JC. Pontiac fever due to Legionella micdadei from a whirlpool spa: Possible role of bacterial endotoxin. ...

171

CERN Multimedia

The next generation of particle accelerator is currently being designed at CERN. An understanding of the market forces in the computer industry will play a crucial role in the success of the project.

1998-01-01

172

Bacterial flora-typing with targeted, chip-based Pyrosequencing

Atmospheric chemistry in volcanic plumes

BackgroundThe metagenomic analysis of microbial communities holds the potential to improve our understanding of the role of microbes in clinical conditions. Recent, dramatic improvements...Full Text Available

173

Approaches to the evaluation of chemical-induced immunotoxicity.

Recent field observations have shown that the atmospheric plumes of quiescently degassing volcanoes are chemically very active, pointing to the role of chemical cycles involving halogen species and...Full Text Available

2010-04-13

174

Antioxidents and the costs of egg production: Studies in the Green Turtle (Chelonoa mydas)

The immune system plays a crucial role in maintaining health; however, accumulating evidence indicates that this system can be the target for immunotoxic effects caused by a variety of chemicals including...Full Text Available

1995-12-01

175

Environmental Research Database

DescriptionThis Studentship will focus on the implications of material nutrition and health for reproduction in green turtles, and specifically the role played by dietary carotenoids.

2009-01-30

176

APOPTOSIS BY DIETARY AGENTS FOR PREVENTION AND TREATMENT OF CANCER

A Role for the Army Medical Specialist Corps in Nation ...

The role of apoptosis or programmed cell death in the regulation of development and maintenance of homeostasis in multicellular organisms is well established. During the last decade, naturally...Full Text Available

2008-12-01

177

"1"5N-"1"4N study of the role of the leaf in the nitrogen nutrition of the seed of Datura stramonium L

... in MEDCAP "the level of interface was left up ... of these patients had peripheral nerve injuries, head ... with poorly constructed prosthesis or waiting for ...

1993-04-13

178

The ecological role of bacteriocins in bacterial competition.

... amino acids carbon 14 glutamine leaves nitrogen 14 nitrogen 15 nutrition

179

The India-Pakistan-China strategic triangle and the role of nuclear weapons

Bacteriocins are an abundant class of antimicrobial molecules that appear to mediate population dynamics within species. The bacteriocins of Escherichia coli have served as a model for exploring the ecological role of these potent toxins. Studies suggest that colicins provide a competitive edge in nutrient-poor environments and that there might be a trade-off between the costs and benefits of colicin production. PMID:10203843

1999-03-01

180

Tachyons: may they have a role in elementary particle physics

This paper presents the Asian landscape with its regional balances and imbalances and its changes after September 11 and subsequent events. The nuclear posture and the role of nuclear weapons inside the China-India-Pakistan triangle is analyzed with respect to the US non-proliferation policy and its expanding military presence over the Asian continent. (J.S.)

2002-07-01

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181

Role of mechanical vibration in preventive maintenance programmes

The possible role of space-like objects in elementary particle physics (and in quantum mechanics) is reviewed and discussed, mainly by exploiting the explicit consequences of the peculiar relativistic mechanics of Tachyons. Particular attention is paid: (i) to tachyons as the possible carriers of interactions; (ii) to the possibility of ''vacuum decays'' at the classical level; (iii) to a Lorentz-invariant bootstrap model; (iv) to the apparent shape of the tachyonic elementary particles and its possible connection with the de Broglie wave-particle dualism. (author).

182

Gamma interferon induces rapid and coordinate activation of mitogen-activated protein kinase (extracellular signal-regulated kinase) and calcium-independent protein kinase C in human monocytes.

Vibration of machinery plays an important role in preventive maintenance programs of machinery. It can be applied in different phases ranging from simple to computerized programs. The advantages of applying machine condition monitoring programs are numerous since vibration measurement and analysis leads to the early detection of component deterioration. The cost, savings and some details of the vibration preventive maintenance program are discussed.

1989-11-01

183

Elucidating novel pathways and regulation of nitrogen assimilation in alpha proteobacteria exemplified by the soil organism Paracoccus denitrificans

Gamma interferon plays an important role in regulating the functional properties of mononuclear phagocytes. In the present study, the role of activated protein kinases in the mechanism of action of...Full Text Available

1994-07-01

184

Environmental Research Database

DescriptionThe importance of inorganic nitrate for the nutrition and growth of marine and freshwater autotrophic phytoplankton has long been recognised, in particularly because of the 'blooms' formed in nitrate and phosphate polluted water and their possible roles as carbon dioxide sinks. By contrast, the utilisation of nitrate by heterotrophic bacteria has historically received less attention. Up until now, the primary role of heterotrophic bacteria has classically been considered to be the decomposition [continued...

2010-01-31

185

Cumulative hadron production in quark models of flucton fragmentation

Comparative analysis of the ATRX promoter and 5' regulatory region reveals conserved regulatory elements which are linked to roles in neurodevelopment, alpha-globin regulation and testicular function

Quark models of cumulative particle production and EMS effect are analyzed. All the models are characterized by a universal relationship between the spectrum of cumulative nucleons and the cross section of cumulative particles containing valence nuclear quarks. This relationship is tested for a deuteron. The role is discussed played by secondary nuclear processes for heavy nuclei. A special role of ''sea'' cumulative particles (K"-, p-bar) is pointed out in understanding the nature of the difference between the structure functions of a nucleus and of free nucleon.

186

Role of natural organic matter (NOM), colloidal particles, and solution chemistry on ultrafiltration performance

BackgroundATRX is a tightly-regulated multifunctional protein with crucial roles in mammalian development. Mutations in the ATRX gene cause ATR-X syndrome, an X-linked...Full Text Available

187

British Library Electronic Table of Contents (United Kingdom)

Mechanistic studies on a charged ultrafiltration (UF) membrane fouled with natural organic matter (NOM) and colloidal particles are systematically investigated to understand the relative role of each NOM fraction and the presence of colloidal particulate to membrane fouling. Humic acid (HA), dextran, and kaolin were employed as surrogate model foulants representing the organic hydrophobic acid NOM, hydrophilic neutral NOM, and inorganic colloidal materials, respectively. The results obtained showed that the organic NOM of hydrophilic surrogate (dextran) plays a primary role in promoting membrane fouling, followed by hydrophobic acids and inorganic kaolin, but to a lesser extent than organic NOM compounds. Significant differences in the extent of fouling between dextran and HA have been obs...

2011-01-01

188

Proceedings of the PHEV 2007 conference : where the grid meets the road

Investigation by physical methods of the possible role of telomeres in DNA in aging process

This conference examined the potential role of plug-in hybrid electric vehicles (PHEVs) which are gaining interest around the world. Emerging PHEV technologies were reviewed along with the role that biofuels and electricity play in their widespread use. It was attended by members of industry, academia, utilities, government and institutions to review on-going research and demonstrations of PHEV projects across North America. The purpose was to understand how PHEV technologies can be integrated into current and future transportation systems and the electrical power grid. Other objectives were to establish a primarily-Canadian network focused on PHEV-related issues to promote public engagement for the plug-in highway. The possible role of government support for PHEV research, development and commercialization was also discussed. In addition to workshops and poster sessions, this conference featured 75 presentations, of which ...

2007-11-01

189

CERN Document Server

The interaction energies between the different types of bases of a single strand of DNA molecule have been calculated. Using these original values of energies the harmonic behavior of a number of base patterns of DNA has been studied. In view of the great interest aroused by the discovery of the role of the telomere segment of the DNA in the replication process and its possible link with the aging process, we have investigated, with simple models, the harmonic behavior of the telomeric pattern of bases as well as the thermodynamic response in the biological system. With these results a conclusion on the probable role of the telomeric pattern on aging has also been drawn. Here the calculated values of harmonic frequencies of the telomeric pattern of bases and of other possible patterns show that the telomeric pattern is associated with the highest vibrational frequency among all patterns of base combinations at the replication end of DNA. This ...

2003-01-01

190

metabotropic glutamate receptor 5 (mGluR5) has a critical role in inhibitory learning

Workshop on stems and trunks in plant form and function. Final report

The mechanisms that contribute to the extinction of previously acquired memories are not well understood. These processes, often referred to as inhibitory learning, are thought to be parallel...Full Text Available

2009-03-25

191

What is the next step in patient decision support?

This document is the final report on the workshop on stems and trunks in plant form and function relating to DOE grant DE-FG06-93ER20128 which took place at Oregon State University in February 1994. The resulting book is organized into four sections and a synthesis: roles of stem architecture in plant performance, roles of stems in transport and storage of water, roles of live stem cells in plant performance, and the roles of stems in preventing or reacting to response to plant injury. The synthesis stemmed from debated and discussion by the authors and a few dozen other workshop participants. The authors cover many stem functions, although the list is not exhaustive, and the focus is on terrestrial woody tree stems, primarily of temperate and boreal zones. More research on trunks, branches and twigs is important for a baseline understanding of plant biology. In the face of anticipated human-caused ...

1995-03-01

192

Virtual adult ears reveal the roles of acoustical factors and experience in auditory space map development

Patient decision support systems have a promising role in the delivery of health care. However, the best approach for further development of these systems is a matter of speculation. To help chart a...Full Text Available

2000-01-01

193

Virological and serological surveillance for type A influenza in the black-legged kittiwake (Rissa tridactyla)

Auditory neurons in the superior colliculus (SC) respond preferentially to sounds from restricted directions to form a map of auditory space. The development of this representation is shaped...Full Text Available

2008-11-05

194

Variants in Inflammation Genes and the Risk of Biliary Tract Cancers and Stones: A Population-based Study in China

BackgroundThe epidemiology of avian influenza viruses (AIVs) in gulls is only partially known. The role of the world's most numerous gull species, the black-legged kittiwake (Rissa...Full Text Available

195

Variant influenza virus hemagglutinin that induces fusion at elevated pH.

To evaluate the role of chronic inflammation in the development of gallstones and biliary tract cancer, we examined the risk associated with 62 single nucleotide polymorphisms (SNPs), including...Full Text Available

2008-08-01

196

Use of Forward Genetics to Discover Novel Regulators of NF-?B

The hemagglutinin (HA) glycoprotein of influenza virus performs two critical roles during infection: it binds virus to cell surface sialic acids, and under mildly acidic conditions it induces fusion...Full Text Available

1986-02-01

197

Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?

Forward and reverse genetic experiments have both played important roles in revealing critical aspects of mammalian signal transduction pathways in cell culture experiments. Only recently have we begun...Full Text Available

2010-06-01

198

Update on the Role of Substantia Nigra Pars Reticulata in the Regulation of Seizures

The oxidative stress theory of aging predicts that manipulations that alter oxidative stress/damage will alter aging. The gold standard for determining whether aging is altered is lifespan,...Full Text Available

2010-03-01

199

Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects

The substantia nigra pars reticulata (SNR) represents an endogenous seizure suppressing system, which may be targeted to develop treatments for generalized or multifocal epilepsies. This review summarizes...Full Text Available

2006-05-01

200

UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications

For an enzyme functioning predominantly in a seemingly housekeeping role of 5′ tRNA maturation, RNase P displays a remarkable diversity in subunit make-up across the three domains of...Full Text Available

2010-01-21

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201

Type IVB Secretion Systems of Legionella and Other Gram-Negative Bacteria

Cytosine methylation in DNA is a major epigenetic signal, and plays a central role in propagating chromatin status during cell division. However the mechanistic links between DNA methylation...Full Text Available

2009-01-01

202

Tumour-stromal interactions: Phenotypic and genetic alterations in mammary stroma - implications for tumour progression

Type IV secretion systems (T4SSs) play a central role in the pathogenicity of many important pathogens, including Agrobacterium tumefaciens, Helicobacter pylori, and...Full Text Available

203

Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice

In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in...Full Text Available

2001-01-01

204

Transient Hoogsteen Base Pairs in Canonical Duplex DNA

BackgroundThe dynorphin-kappa opioid receptor (KOR) system regulates glial proliferation after sciatic nerve injury. Here, we investigated its role in cell proliferation following...Full Text Available

205

Transcriptome Profiling of a Toxic Dinoflagellate Reveals a Gene-Rich Protist and a Potential Impact on Gene Expression Due to Bacterial Presence

Sequence-directed variations in the canonical DNA double helix structure that retain Watson-Crick base-pairing play important roles in DNA recognition, topology, and nucleosome positioning....Full Text Available

2011-02-24

206

Trans-Species Polymorphism and Selection in the MHC Class II DRA Genes of Domestic Sheep

BackgroundDinoflagellates are unicellular, often photosynthetic protists that play a major role in the dynamics of the Earth's oceans and climate. Sequencing of dinoflagellate nuclear...Full Text Available

207

Towards computational prediction of microRNA function and activity

Highly polymorphic genes with central roles in lymphocyte mediated immune surveillance are grouped together in the major histocompatibility complex (MHC) in higher vertebrates. Generally, across vertebrate...Full Text Available

208

Tone-Specific and Nonspecific Plasticity of the Auditory Cortex Elicited by Pseudoconditioning: Role of Acetylcholine Receptors and the Somatosensory Cortex

While it has been established that microRNAs (miRNAs) play key roles throughout development and are dysregulated in many human pathologies, the specific processes and pathways regulated by individual...Full Text Available

2010-08-01

209

Three-Dimensional Traction Force Microscopy: A New Tool for Quantifying Cell-Matrix Interactions

Experience-dependent plastic changes in the central sensory systems are due to activation of both the sensory and neuromodulatory systems. Nonspecific changes of cortical auditory neurons elicited by...Full Text Available

2008-09-01

210

The underestimated role of olfaction in avian reproduction ?

The interactions between biochemical processes and mechanical signaling play important roles during various cellular processes such as wound healing, embryogenesis, metastasis, and cell migration. While...Full Text Available

211

The structural design of the bat wing web and its possible role in gas exchange

Until the second half of the 20^th century, it was broadly accepted that most birds are microsmatic if not anosmic and unable to detect and use olfactory information. Exceptions were...Full Text Available

2009-06-25

212

The role of the immune system in hexachlorobenzene-induced toxicity.

The structure of the skin in the epauletted fruit bat (Epomophorus wahlbergi) wing and body trunk was studied with a view to understanding possible adaptations for gas metabolism and...Full Text Available

2007-12-01

213

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

Hexachlorobenzene (HCB) is a persistent environmental pollutant. The toxicity of HCB has been extensively studied after an accidental human poisoning in Turkey and more recently it has been shown that...Full Text Available

1999-10-01

214

The role of skin absorption as a route of exposure for volatile organic compounds (VOCs) in drinking water.

Purpose of ReviewThe vertebrate cap’n’collar family transcription factor Nrf2 and its invertebrate homologs SKN-1 (in worms) and CncC (in flies) function...Full Text Available

2011-01-01

215

The role of metallothionein IIa in defending lens epithelial cells against cadmium and TBHP induced oxidative stress

Assessments of drinking water safety rely on the assumption that ingestion represents the principal route of exposure. A review of the experimental literature revealed that skin penetration rates for...Full Text Available

1984-05-01

216

The role of grain boundary chemistry and structure in the environmentally-assisted intergranular cracking of nickel-base alloys. Progress report, August 1, 1991--July 31, 1992

PurposeHeavy metals and other forms of oxidative stress have been implicated as key factors in the formation of age-related cataract in humans. Metallothioneins are...Full Text Available

217

The role of grain boundary chemistry and structure in the environmentally-assisted intergranular cracking of nickel-base alloys

Stress corrosion cracking tests in constant extension rate tensile (CERT) and constant load tensile (CLT) tests were conducted on Ni-xCr- 9Fe-yC in Ar, water, and a LiOH-boric acid solution. Cr and C improve the resistance of Ni-base alloys to IG cracking in both Ar and water at 360C. Since creep plays a role in IG cracking, one possible explanation for the role of the environment involves its effect on the creep. Experiments were conducted on the role of C in the deformation behavior and failure mode of Ni-16Cr-9Fe. Constant load experiments were conducted on Ni-16Cr-9Fe to determine if the CLT test is more aggressive than CERT. The electron backscattering technique in a SEM is being developed in order to extend the IG cracking studies to grain sizes typical of commercial alloys, 20-30 microns.

1992-07-01

218

The role of gene expression in ecological speciation

Stress corrosion cracking tests in constant extension rate tensile (CERT) and constant load tensile (CLT) tests were conducted on Ni-xCr- 9Fe-yC in Ar, water, and a LiOH-boric acid solution. Cr and C improve the resistance of Ni-base alloys to IG cracking in both Ar and water at 360C. Since creep plays a role in IG cracking, one possible explanation for the role of the environment involves its effect on the creep. Experiments were conducted on the role of C in the deformation behavior and failure mode of Ni-16Cr-9Fe. Constant load experiments were conducted on Ni-16Cr-9Fe to determine if the CLT test is more aggressive than CERT. The electron backscattering technique in a SEM is being developed in order to extend the IG cracking studies to grain sizes typical of commercial alloys, 20-30 microns.

1992-07-01

219

The role of cryoanalgesia for chronic thoracic pain: results of a long-term follow up.

Ecological speciation is the process by which barriers to gene flow between populations evolve due to adaptive divergence via natural selection. A relatively unexplored area in ecological speciation...Full Text Available

2010-09-01

220

The role of calcium ions and calcium channel entry blockers in experimental ischemia-reperfusion-induced liver injury.

Cryoanalgesia (the use of cold to provide anesthesia or analgesia) is the oldest anesthetic and analgesic still in current clinical use. Its intraoperative use in providing postoperative analgesia for...Full Text Available

2002-08-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

221

The role of Holliday junction resolvases in the repair of spontaneous and induced DNA damage

Verapamil administered before treatment, but not after treatment, had a beneficial effect on a 90-minute warm ischemia-reperfusion rat liver injury model. The possible activation of proteases converting...Full Text Available

1991-02-01

222

The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome

DNA double-strand breaks (DSBs) and other lesions occur frequently during cell growth and in meiosis. These are often repaired by homologous recombination (HR). HR may result in the formation of DNA...Full Text Available

2011-09-01

223

The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe Disease

FRAXA is one of a number of fragile sites in human chromosomes that are induced by agents like fluorodeoxyuridine (FdU) that affect intracellular thymidylate levels. FRAXA coincides with a >200...Full Text Available

2009-07-01

224

The relative roles of bipolar disorder and psychomotor agitation in substance dependence

Krabbe disease (KD) is an inherited neurological disorder caused by the deficiency of galactocerebrosidase activity resulting in accumulation of psychosine, which leads to energy depletion,...Full Text Available

2008-06-01

225

The relationship between the rate of melatonin excretion and sleep consolidation for locomotive engineers in natural sleep settings

Previous studies have shown that both bipolar disorder (BPD) and psychomotor agitation (PMA) are associated with substance dependence. These two findings have yet to be integrated, despite evidence...Full Text Available

2010-06-01

226

The region encompassing the procyclic acidic repetitive protein (PARP) gene promoter plays a role in plasmid DNA replication in Trypanosoma brucei.

BackgroundThe aim of the study was to examine the role that melatonin production plays in the regulation of sleep consolidation in a population of shiftworkers working and sleeping...Full Text Available

227

The potential role of phrenic nucleus glutamate receptor subunits in mediating spontaneous crossed phrenic activity in neonatal rat

We have previously reported the construction and characterization of an autonomously replicating plasmid in Trypanosoma brucei. In this plasmid the procyclic acidic repetitive protein (PARP) gene promoter...Full Text Available

1994-10-11

228

The physics of automatic letter sorting

Cervical spinal cord hemisection rostral to the phrenic nucleus leads to paralysis of the ipsilateral hemidiaphragm in adult rats. Respiratory function can be restored to the paralyzed hemidiaphragm...Full Text Available

2009-08-01

229

The olympic brain. Does corticospinal plasticity play a role in acquisition of skills required for high-performance sports?

The astronomical number of letters handled by the Post Office makes automatic sorting technology essential. Key roles are played by the postcode system and an ink-jet printer that has been developed to use phosphorescent inks.

1988-07-01

230

The kiwifruit lycopene beta-cyclase plays a significant role in carotenoid accumulation in fruit

Non-invasive electrophysiological and imaging techniques have recently made investigation of the intact behaving human brain possible. One of the most intriguing new research areas that have developed...Full Text Available

2008-01-01

231

The RpoT Regulon of Pseudomonas putida DOT-T1E and Its Role in Stress Endurance against Solvents?

The composition of carotenoids, along with anthocyanins and chlorophyll, accounts for the distinctive range of colour found in the Actinidia (kiwifruit) species. Lutein and beta-carotene...Full Text Available

2009-09-01

232

The Role of the Pattern Edge in Goldfish Visual Motion Detection

Pseudomonas putida encodes 20 extracytoplasmic sigma factors (ECFs). In this study, we show that one of these ECFs, known as ECF-Pp12...Full Text Available

2007-01-01

233

The Role of Thyroid Hormone in Testicular Development and Function

To understand the function of edges in perception of moving objects, we defined four questions to answer. Is the focus point in visual motion detection of a moving object: (1) the body or the edge of...Full Text Available

2010-12-01

234

The Role of Shoe Design in Ankle Sprain Rates Among Collegiate Basketball Players

Thyroid hormone is a critical regulator of growth, development and metabolism in virtually all tissues, and altered thyroid status affects many organs and systems. Although for many years testis...Full Text Available

2008-12-01

235

The Role of Placental Homeobox Genes in Human Fetal Growth Restriction

Context:Much of the recent focus in shoe design and engineering has been on improving athletic performance. Currently, this improvement has been in the form of “cushioned...Full Text Available

2008-05-01

236

The Role of Anticipatory Postural Adjustments in Compensatory Control of Posture: 2. Biomechanical Analysis

Fetal growth restriction (FGR) is an adverse pregnancy outcome associated with significant perinatal and paediatric morbidity and mortality, and an increased risk of chronic disease later in adult life....Full Text Available

2011-01-01

237

The Regulation of Aging and Longevity

The central nervous system (CNS) utilizes anticipatory (APAs) and compensatory (CPAs) postural adjustments to maintain equilibrium while standing. It is known that these postural adjustments...Full Text Available

2010-06-01

238

The QseC Adrenergic Signaling Cascade in Enterohemorrhagic E. coli (EHEC)

p53 plays a critical role in tumor suppression. As a transcription factor, in response to stress signals, p53 regulates its target genes and initiates stress responses, including cell cycle arrest,...Full Text Available

2011-04-01

239

The Pseudoreceptor BMP and Activin Membrane-bound Inhibitor Positively Modulates Wnt/?-Catenin Signaling*

The ability to respond to stress is at the core of an organism's survival. The hormones epinephrine and norepinephrine play a central role in stress responses in mammals, which require the synchronized...Full Text Available

2009-08-01

240

The Promise of Prevention: The Effects of Four Preventable Risk Factors on National Life Expectancy and Life Expectancy Disparities by Race and County in the United States

The canonical Wnt/β-catenin pathway plays a pivotal role in regulating embryogenesis and tumorigenesis by promoting cell proliferation. BAMBI (BMP and activin membrane-bound inhibitor) has...Full Text Available

2008-11-28

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

241

The Functional Role of Calcineurin in Hypertrophy, Regeneration, and Disorders of Skeletal Muscle

BackgroundThere has been substantial research on psychosocial and health care determinants of health disparities in the United States (US) but less on the role of modifiable risk...Full Text Available

2010-03-01

242

The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence

Skeletal muscle uses calcium as a second messenger to respond and adapt to environmental stimuli. Elevations in intracellular calcium levels activate calcineurin, a serine/threonine phosphatase, resulting...Full Text Available

2010-01-01

243

The ATP-Binding Cassette Transporter ABCA4: Structural and Functional Properties and Role in Retinal Disease

The fungal pathogen Candida albicans is one of the leading causative agents of death in immunocompromised individuals. It harbors an arsenal of cell wall anchored factors that are implicated...Full Text Available

2011-01-01

244

Test-retest reliability of knee kinesthesia in healthy adults

ATP-binding cassette transporters (ABC transporters) utilize the energy of ATP hydrolysis to translocate an unusually diverse set of substrates across cellular membranes. ABCA4, also known as...Full Text Available

2010-01-01

245

Targeting the p53 Pathway in Ewing Sarcoma

BackgroundSensory information from mechanoreceptors in the skin, muscles, tendons, and joint structures plays an important role in joint stability. A joint injury can lead to disruption...Full Text Available

246

Targeted Deletion of Somatotroph Insulin-Like Growth Factor-I Signaling in a Cell-Specific Knockout Mouse Model

The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent antitumour surveillance mechanisms of p53 through mutation of the TP53...Full Text Available

2011-01-01

247

Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis

The role of IGF-I in the negative regulation of GH expression and release is demonstrated by in vitro and in vivo models; however, the targets and mechanisms of IGF-I...Full Text Available

2010-05-01

248

THE ROLE OF SALIVA IN TICK FEEDING

SYNOPSISRhomboid proteases are a fascinating class of enzymes that combine a serine protease active site within the core of an integral membrane protein. Despite having key roles...Full Text Available

249

Synthetic substrates for measuring activity of autophagy proteases

When attempting to feed on their hosts, ticks face the problem of host hemostasis (the vertebrate mechanisms that prevent blood loss), inflammation (that can produce itching or pain and thus...Full Text Available

250

Synthesis and Phosphorylation of Maize Acidic Ribosomal Proteins1

Atg4 cysteine proteases (autophagins) play crucial roles in autophagy by proteolytic activation of Atg8 paralogs for targeting to autophagic vesicles by lipid conjugation, as well as in subsequent deconjugation...Full Text Available

2010-10-01

251

Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation

The objective of this research was to determine the role of acidic ribosomal protein (ARP) phosphorylation in translation. Ribosomes (Rbs) from germinated maize (Zea mays L.) axes had...Full Text Available

1998-01-01

252

Studies on the mechanism of 1,3-butadiene-induced leukemogenesis: the potential role of endogenous murine leukemia virus.

The CCR4-NOT complex is the main enzyme catalyzing the deadenylation of mRNA. We have investigated the composition of this complex in Drosophila melanogaster by immunoprecipitation...Full Text Available

2010-07-01

253

Studies on micellar fatty acid uptake by rat intestine in vitro with reference to the role of bile

Previous studies have revealed marked differences in the incidence of leukemia between rats and mice exposed to 1,3-butadiene that do not appear to be readily explained on the basis of pharmacokinetics...Full Text Available

1990-06-01

254

Structure and Reaction Mechanism of Basil Eugenol Synthase

1. The uptake and esterification to trigylceride of oleic acid in micellar form was studied in rat intestine in vitro. Sacs of the upper half of the everted intestine taken from bile...Full Text Available

1973-03-01

255

Stereocomplexed PLA-PEG Nanoparticles with Dual-Emissive Boron Dyes for Tumor Accumulation

Phenylpropenes, a large group of plant volatile compounds that serve in multiple roles in defense and pollinator attraction, contain a propenyl side chain. Eugenol synthase (EGS) catalyzes the reductive...Full Text Available

256

Spread of a highly mucoid Streptococcus pyogenes emm3/ST15 clone

Responsive biomaterials play important roles in imaging, diagnostics, and therapeutics. Polymeric nanoparticles (NPs) containing hydrophobic and hydrophilic segments are one class of biomaterial...Full Text Available

2010-09-28

257

Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors

BackgroundHyaluronic acid capsule plays a key role in Streptococcus pyogenes virulence. Circulation of mucoid or highly encapsulated strains has been related to...Full Text Available

258

Socioeconomic Status and Depressive Syndrome: The Role of Inter- and Intra-generational Mobility, Government Assistance, and Work Environment*

BackgroundPeroxiredoxins (Prxs) have recently been suggested to have a role in tumorigenesis.MethodsWe studied the expression of Prx I-VI and their...Full Text Available

259

Sociodemographic factors in a pediatric chronic pain clinic: The roles of age, sex and minority status in pain and health characteristics

This paper assesses the hypothesis that depressive syndrome is associated with socioeconomic status, using longitudinal data from the Baltimore Epidemiologic Catchment Area Followup. Socioeconomic...Full Text Available

2001-09-01

260

Social Work Role in Pain Management with Hospice Caregivers: A National Survey

Little is known about how sociodemographic factors relate to children’s chronic pain. This paper describes the pain, health, and sociodemographic characteristics of a cohort of children...Full Text Available

2010-07-01

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261

SirT3 suppresses hypoxia inducible factor 1? and tumor growth by inhibiting mitochondrial ROS production

This article reports on an exploratory study of hospice social workers’ assessment and collaborative practices related to pain management; especially caregiver concerns about patient...Full Text Available

2009-01-01

262

SirT1 brings stemness closer to cancer and aging

It has become increasing clear that alterations in cellular metabolism have a key role in the generation and maintenance of cancer. Some of the metabolic changes can be attributed to the activation...Full Text Available

2011-06-30

263

Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism

Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of...Full Text Available

264

Short RNA half-lives in the slow-growing marine cyanobacterium Prochlorococcus

BackgroundMicrovascular injury plays a key role in normal tissue radiation responses. Statins, in addition to their lipid-lowering effects, have vasculoprotective...Full Text Available

2007-08-01

265

Sexual differentiation of the zebra finch song system: potential roles for sex chromosome genes

BackgroundRNA turnover plays an important role in the gene regulation of microorganisms and influences their speed of acclimation to environmental changes. We investigated whole-genome...Full Text Available

2010-01-01

266

Serum protein binding and the role of increased alpha 1-acid glycoprotein in moderately obese male subjects.

BackgroundRecent evidence suggests that some sex differences in brain and behavior might result from direct genetic effects, and not solely the result of the organizational effects...Full Text Available

267

Serum RANKL, osteoprotegerin (OPG), and RANKL/OPG ratio in nephrotic children

Serum protein and lipid concentrations as well as the serum protein binding of propranolol, diazepam and phenytoin were measured in normal weight and obese volunteers. Concentrations of alpha 1-acid...Full Text Available

1984-12-01

268

Safety Nets and Scaffolds: Parental Support in the Transition to Adulthood

Receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) play key roles in the pathogenesis of glucocorticoid-induced osteoporosis (GIO). The aim of our study was to determine whether the...Full Text Available

2010-10-01

269

Rolling tachyons in string cosmology

Using longitudinal data from the Youth Development Study (analytic sample N = 712), we investigate how age, adult role acquisition and attainments, family resources, parent-child relationship...Full Text Available

2011-04-01

270

Roles of lead-binding proteins in mediating lead bioavailability.

We study the role of rolling tachyons in the cosmological model with dilatonic gravity. In the string frame, flat space solutions of both initial-stage and late-time are obtained in closed form. In the Einstein frame, we show that every expanding solution is decelerating.

2003-01-23

271

Role of vasopressin in regulation of renal kinin excretion in Long-Evans and diabetes insipidus rats.

The intracellular bioavailability of lead (Pb) at low dosage levels in major target organs such as the kidney and brain appears to be largely determined by complexation with a group of low molecular...Full Text Available

1998-12-01

272

Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits.

To study the relationship between vasopressin and the renal kallikrein-kinin system we measured the rate of excretion of kinins into the urine of anesthetized rats during conditions of increased and...Full Text Available

1984-03-01

273

Role of the nac gene product in the nitrogen regulation of some NTR-regulated operons of Klebsiella aerogenes.

A regulatory locus on the Staphylococcus aureus chromosome, designated sar, is involved in the expression of cell wall proteins, some of which are potentially important in the pathogenesis of endocarditis....Full Text Available

1994-05-01

274

Role of the Domestic Chicken (Gallus gallus)in the Epidemiology of Urban Visceral Leishmaniasis in Brazil

A positive, genetic selection against the activity of the nitrogen regulatory (NTR) system was used to isolate insertion mutations affecting nitrogen regulation in Klebsiella aerogenes. Two classes...Full Text Available

1990-12-01

275

Role of surface degrees of freedom in grazing heavy ion collisions

Zoonotic visceral leishmaniasis (ZVL) is a serious public health problem in several Brazilian cities. Although the proximity of chicken houses is often cited as a risk factor in studies of urban ZVL,...Full Text Available

2002-12-01

276

Role of surface degrees of freedom in grazing heavy ion collisions

A survey is given of the influence of surface deformations on heavy ion reactions. Emphasis is put on the effect of zeropoint fluctuations in the entrance channel and on the effect on grazing collisions in terms of an imaginary part of the scattering potential.

1983-11-14

277

Role of sodium in the growth of a ruminal selenomonad.

A survey is given of the influence of surface deformations on heavy ion reactions. Emphasis is put on the effect of zeropoint fluctuations in the entrance channel and on the effect on grazing collisions in terms of an imaginary part of the scattering potential. (orig.).

278

Role of ocular involvement in the prediction of visual development and clinical prognosis in Aicardi syndrome.

The ruminal selenomonad strain H18 grew rapidly (mu = 0.50 h-1) in a defined medium containing glucose, ammonia, purified amino acids, and sodium (95 mM); little if any ammonia was utilized as a nitrogen...Full Text Available

1991-06-01

279

Role of nitroso radicals as drug targets in circulatory shock

AIMS/BACKGROUND: This study was undertaken to document visual function and acuity in patients with Aicardi syndrome, and to determine whether there is any relation between ocular features of the syndrome...Full Text Available

1996-09-01

280

Role of narK2X and narGHJI in Hypoxic Upregulation of Nitrate Reduction by Mycobacterium tuberculosis

A vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially, superoxide and hydroxyl radical) and high-energy oxidants [such as peroxynitrite (OONO⁻)]...Full Text Available

2009-06-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

281

Role of interferon-gamma in interleukin 12-induced pathology in mice.

Mycobacterium tuberculosis is one of the strongest reducers of nitrate in the genus Mycobacterium. Under microaerobic conditions, whole cells exhibit upregulation of...Full Text Available

2003-12-01

282

Role of histone methylation and demethylation in adipogenesis and obesity

Interleukin 12 (IL-12) activates natural killer (NK) and T cells with the secondary synthesis and release of interferon-gamma (IFN-gamma) and other cytokines. IL-12-induced organ alterations are reported...Full Text Available

1995-12-01

283

Role of copper resistance in competitive survival of Pseudomonas fluorescens in soil.

Adipocyte differentiation is a complex developmental process that involves the coordinated interplay of numerous transcription factors. PPARγ has emerged as a master regulator of adipogenesis...Full Text Available

2010-01-01

284

Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells

A copper-resistant strain (09906) of Pseudomonas fluorescens that was isolated from a citrus grove soil is being investigated as a biological control agent for Phytophthora root rot. Since citrus grove...Full Text Available

1993-02-01

285

Role of ankle taping and bracing in the athlete.

BackgroundGlycochenodeoxycholate (GCDA) is one of the major human bile salts. Bile salts stimulate cell survival and proliferation through the mitogen-activated protein kinase, but...Full Text Available

286

Role of adenosine in regulating glucose uptake during contractions and hypoxia in rat skeletal muscle

Adhesive tape is often used to help athletes recover from ligament sprains of the ankle or to prevent further injury. The choice of taping technique or material is often decided by personal preference,...Full Text Available

1997-06-01

287

Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage

The effect of A₁-adenosine receptor antagonism via 8-cyclopentyl-1,3-dipropyl-xanthine (CPDPX) on the stimulation of skeletal muscle glucose uptake by...Full Text Available

1999-02-15

288

Role of Respiratory Nitrate Reductase in Ability of Pseudomonas fluorescens YT101 To Colonize the Rhizosphere of Maize

Acetaminophen (N-acetyl-para-aminophenol (APAP), paracetamol) is a commonly used analgesic and antipyretic agent. Although considered safe at therapeutic doses, accidental or intentional...Full Text Available

2011-06-01

289

Role of Quantitative Bone Scanning in the Assessment of Bone Turnover in Patients With Charcot Foot

Selection of the denitrifying community by plant roots (i.e., increase in the denitrifier/total heterotroph ratio in the rhizosphere) has been reported by several authors. However, very few studies...Full Text Available

2000-09-01

290

Role of Military Workingn> Dogs in Low Intensity Conflict.

OBJECTIVETo assess the new quantitative bone scan parameters as markers of Charcot neuroosteoarthropathy (CNO) activity.RESEARCH DESIGN AND METHODSForty-two...Full Text Available

2010-02-01

291

Role of Methoxypolyethylene Glycol on the Hydration, Activity, Conformation and Dynamic Properties of a Lipase in a Dry Film

This paper examines the current military working dogs (MWD) program, its historical roots, and the possibility for expansion of the program. Current service MWD programs will be discussed, as well as possible models for change. The primary focus is on the...

1990-01-01

292

Role of Estrogen Receptor-? in the Regulation of Claudin-6 Expression in Breast Cancer Cells

A combined approach based on the use of ATR-FT/IR and steady-state fluorescence spectroscopy allowed to shed light on the effects of the additive methoxypolyethylene glycol (MePEG) on the hydration,...Full Text Available

2008-10-01

293

Role of Cytokinin and Auxin in Shaping Root Architecture: Regulating Vascular Differentiation, Lateral Root Initiation, Root Apical Dominance and Root Gravitropism

PurposeIn our previous studies we showed that upregulating claudin-6 (CLDN6) expression may contribute to preventing breast cancer, and that 17β-estradiol induces a concentration-...Full Text Available

2011-03-01

294

Role of Conserved Salt Bridges in Homeodomain Stability and DNA Binding*

• Background and Aims Development and architecture of plant roots are regulated by phytohormones. Cytokinin (CK), synthesized in the root cap, promotes cytokinesis, vascular...Full Text Available

2006-05-01

295

Role of Calcium in Serine Transport into Tobacco Cells

The sequence information available for homeodomains reveals that salt bridges connecting pairs 19/30, 31/42, and 17/52 are frequent, whereas aliphatic residues at these sites are rare and mainly restricted...Full Text Available

2009-08-28

296

Role of Calcitonin Gene-Related Peptide in Bone Repair after Cyclic Fatigue Loading

The transport of serine into tobacco (Nicotiana tabacum L. var. Xanthi) cells grown in liquid medium was studied. Serine transport was maximal below pH 4.0. A time-dependent stimulation...Full Text Available

1978-12-01

297

Role in Virulence of a Brucella abortus Protein Exhibiting Lectin-Like Activity

BackgroundCalcitonin gene related peptide (CGRP) is a neuropeptide that is abundant in the sensory neurons which innervate bone. The effects of CGRP on isolated bone cells have been...Full Text Available

298

Rhythmic expression of an egr-1 transgene in rats distinguishes two populations of photoreceptor cells in the retinal outer nuclear layer

Brucella abortus is a facultative, intracellular zoonotic pathogen which can cause undulant fever in humans and abortions in cattle. A 14-kDa protein of B. abortus...Full Text Available

2006-01-01

299

Rhizosphere Acidification by Iron Deficient Bean Plants: The Role of Trace Amounts of Divalent Metal Ions

PurposeNocturnal rhythms of gene expression in the retina are known to be both darkness- and circadian clock-dependent, but their role and cellular location are not well defined....Full Text Available

300

Regulatory T Cells in Many Flavors Control Asthma

Rhizosphere acidification by Fe-deficient bean (Phaseolus vulgaris L.) plants was induced by trace amounts of divalent metal ions (Zn, Mn). The induction of this Fe-efficiency reaction...Full Text Available

1989-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

Regulation of rat hepatic low density lipoprotein receptors. In vivo stimulation by growth hormone is not mediated by insulin-like growth factor I.

That regulatory T cells (Tregs) have a crucial role in controlling allergic diseases such as asthma is now undisputed. The cytokines most commonly implicated in Treg-mediated suppression of...Full Text Available

2010-05-01

302

RasGrf1 deficiency delays aging in mice

Growth hormone (GH) has an important role in the regulation of hepatic LDL receptor expression and plasma lipoprotein levels. This investigation was undertaken to evaluate if these effects of GH on...Full Text Available

1996-01-15

303

Rapid oscillations in omental lipolysis are independent of changing insulin levels in vivo

RasGRF1 is a Ras-guanine nucleotide exchange factor implicated in a variety of physiological processes including learning and memory and glucose homeostasis. To determine the role of RASGRF1 in aging,...Full Text Available

304

RNA polymerase II trigger loop residues stabilize and position the incoming nucleotide triphosphate in transcription

Abnormal fat metabolism plays an important role in the pathogenesis of obesity-related type 2 diabetes mellitus. This study examined whether free fatty acid levels (FFAs), like insulin levels, oscillate...Full Text Available

2000-08-01

305

Purpose and regulation of stem cells: a systems-biology view from the Caenorhabditis elegans germ line

A structurally conserved element, the trigger loop, has been suggested to play a key role in substrate selection and catalysis of RNA polymerase II (pol II) transcription elongation. Recently resolved...Full Text Available

2010-09-07

306

Pulmonary metabolism of foreign compounds: its role in metabolic activation.

Stem cells are expected to play a key role in the development and maintenance of organisms, and hold great therapeutic promises. However, a number of questions must be answered to achieve an...Full Text Available

2009-01-01

307

Pseudomonas aeruginosa-Candida albicans Interactions: Localization and Fungal Toxicity of a Phenazine Derivative?

The lung has the potential of metabolizing many foreign chemicals to a vast array of metabolites with different pharmacological and toxicological properties. Because many chemicals require metabolic...Full Text Available

1990-04-01

308

Propranolol ameliorates the development of portal-systemic shunting in a chronic murine schistosomiasis model of portal hypertension.

Phenazines are redox-active small molecules that play significant roles in the interactions between pseudomonads and diverse eukaryotes, including fungi. When Pseudomonas aeruginosa...Full Text Available

2009-01-01

309

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation

We investigated the role of early portal hypotensive pharmacotherapy in preventing the development of portal-systemic shunting in a portal hypertensive model of chronic murine schistosomiasis induced...Full Text Available

1991-03-01

310

Prognostic evaluation of metallothionein expression in human colorectal neoplasms.

The parathyroid hormone receptor (PTHR) is a class B G protein-coupled receptor that plays critical roles in bone and mineral ion metabolism. Ligand binding to the PTHR involves interactions to both...Full Text Available

2008-10-28

311

Probiotic Lactobacillus spp. Diminish Helicobacter hepaticus-Induced Inflammatory Bowel Disease in Interleukin-10-Deficient Mice

AIM: To investigate the role of metallothionein in colorectal tumours and the possible relation with other factors associated with tumour progression: expression of cathepsin D (CD), CD44, p53, Rb,...Full Text Available

1999-12-01

312

Preterm low birthweight and the role of oral bacteria

Clinical and experimental evidence has demonstrated the potential role of probiotics in the prevention or treatment of inflammatory bowel disease. Probiotic clones with direct immunomodulatory activity...Full Text Available

2005-02-01

313

Predictors of healthcare professionals' intention and behaviour to encourage physical activity in patients with cardiovascular risk factors

Preterm and low birthweight (PTLBW) continues to be a major cause of mortality and morbidity across the world. In recent years, maternal periodontal disease has been implicated as a risk factor for...Full Text Available

314

Pre- and Postnatal Nutritional Histories Influence Reproductive Maturation and Ovarian Function in the Rat

BackgroundHealthcare professionals can play a crucial role in optimizing the health status of patients with cardiovascular risk factors (abdominal obesity, high blood pressure, low...Full Text Available

315

Platelets in Hyperacute Rejection of Heterotopic Cardiac Allografts in Presensitized Dogs

BackgroundWhile prepubertal nutritional influences appear to play a role in sexual maturation, there is a need to clarify the potential contributions of maternal and childhood influences...Full Text Available

316

Phytoestrogens: epidemiology and a possible role in cancer protection.

Experiments were carried out to determine whether platelet aggregation plays a primary role in cardiac allograft hyperacute rejection, as has been observed in renal allograft hyperacute rejection....Full Text Available

1973-02-01

317

Phytochrome, Nitrate Movement, and Induction of Nitrate Reductase in Etiolated Pea Terminal Buds ¹

Because many diseases of the Western Hemisphere are hormone-dependent cancers, we have postulated that the Western diet, compared to a vegetarian or semivegetarian diet, may alter hormone production,...Full Text Available

1995-10-01

318

Phylometabonomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice

The role of phytochrome in the induction of nitrate reductase of etiolated field peas (Pisum arvense L.) was examined. Terminal bud nitrate concentration increased in darkness, and...Full Text Available

1975-06-01

319

Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice

Insulin resistance plays a central role in type 2 diabetes and obesity, which develop as a consequence of genetic and environmental factors. Dietary changes including high fat diet (HFD) feeding promotes...Full Text Available

320

Pharmacologic interventions in aging hair

OBJECTIVENicotinamide adenine dinucleotides (NAD⁺ and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD⁺-to-NADH ratio is implicated...Full Text Available

2009-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

Patient organisations and the reimbursement process for medicines: an exploratory study in eight European countries

The appearance of hair plays an important role in people’s overall physical appearance and self-perception. With today’s increasing life-expectations, the desire to look youthful plays...Full Text Available

2006-06-01

322

Pathogenic Role of NKT and NK Cells in Acetaminophen-Induced Liver Injury is Dependent on the Presence of DMSO

BackgroundLittle is known about the role European patient organisations play in the process of deciding on reimbursement for medicines. Therefore we explore the...Full Text Available

323

Palindromic Sequence Plays a Critical Role in Human Foamy Virus Dimerization

Dimethyl sulfoxide (DMSO) is commonly used in biological studies to dissolve drugs and enzyme inhibitors with low solubility. While DMSO is generally thought of as being relatively inert, it...Full Text Available

2008-09-01

324

PLESIOTHERAPY FOR NON-MELANOMA SKIN CANCER: INNOVATING TO OVERCOME!

The retroviral RNA genome is dimeric, consisting of two identical strands of RNA linked near their 5′ ends by a dimer linkage structure. Previously it was shown that human foamy virus (HFV)...Full Text Available

2001-04-01

325

P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the Aurora-B Kinase Inhibitor barasertib-hQPA

Background:The non-surgical management of non-melanoma skin cancers is an area requiring clinical investigation. Radiotherapy has a role in treatment for a defined subset...Full Text Available

2010-10-01

326

Only Slight Impact of Predicted Replicative Capacity for Therapy Response Prediction

BackgroundAurora kinases play an essential role in orchestrating chromosome alignment, segregation and cytokinesis during mitotic progression, with both aurora-A and B frequently...Full Text Available

327

Objective assessment of deformable image registration in radiotherapy: A multi-institution study

BackgroundReplication capacity (RC) of specific HIV isolates is occasionally blamed for unexpected treatment responses. However, the role of viral RC in response to antiretroviral...Full Text Available

328

Nucleoside Drugs Induce Cellular Differentiation by Caspase-Dependent Degradation of Stem Cell Factors

The looming potential of deformable alignment tools to play an integral role in adaptive radiotherapy suggests a need for objective assessment of these complex algorithms. Previous studies in this area...Full Text Available

2008-12-01

329

Nucleocapsid and Matrix Protein Contributions to Selective Human Immunodeficiency Virus Type 1 Genomic RNA Packaging

BackgroundStem cell characteristics are an important feature of human cancer cells and play a major role in the therapy resistance of tumours. Strategies to target cancer stem cells...Full Text Available

330

Nuclear Organization and Dynamics of 7SK RNA in Regulating Gene Expression

The nucleocapsid protein (NC) of retroviruses plays a major role in genomic RNA packaging, and some evidence has implicated the matrix protein (MA) of certain retroviruses in viral RNA binding. To further...Full Text Available

1998-03-01

331

Nuclear ? catenin as a potential prognostic and diagnostic marker in patients with colorectal cancer from Hong Kong

Noncoding RNAs play important roles in various aspects of gene regulation. We have identified 7SK RNA to be enriched in nuclear speckles or interchromatin granule clusters (IGCs), a subnuclear domain...Full Text Available

2010-12-01

332

Noise Susceptibility of Cochlear Implant Users: The Role of Spectral Resolution and Smearing

Aims: To study the expression of nuclear β catenin in patients with colorectal cancer, colorectal adenoma, and colorectal polyps to elucidate its role in carcinogenesis, and its...Full Text Available

2003-12-01

333

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

The latest-generation cochlear implant devices provide many deaf patients with good speech recognition in quiet listening conditions. However, speech recognition deteriorates rapidly as the level of...Full Text Available

2005-03-01

334

Natural variation in life history and aging phenotypes is associated with mitochondrial DNA deletion frequency in Caenorhabditis briggsae

Adipose tissue is central to the regulation of energy balance. Two functionally different types of fat are present in mammals: white adipose tissue (WAT), the primary site of triglyceride storage,...Full Text Available

2008-08-21

335

NASA/DOD Aerospace Knowledge Diffusion Research Project. Phase 2: Respondents Including Frequency Distributions.

BackgroundMutations that impair mitochondrial functioning are associated with a variety of metabolic and age-related disorders. A barrier to rigorous tests of the role of mitochondrial...Full Text Available

336

NASA/CR--- _'j_.,- 207636 - NASA Technical Report Server (NTRS)

Phase 2 of the four phase NASA/DoD Aerospace Knowledge Diffusion Research Project was undertaken to study the transfer of scientific and technical information (STI) from government to the aerospace industry and the role of librarians and technical informa...

1991-01-01

337

Molecular dynamics of a ?B DNA element: base flipping via cross-strand intercalative stacking in a microsecond-scale simulation

adenines, like adenine itself, may fllerefore have played an important role in the. RNA world. Griffin, B.E., Haslam, W.J., Reese, C. B.: 1964, J. Mo/. ...

338

Modulation of leg muscle function in response to altered demand for body support and forward propulsion during walking

The sequence-dependent structural variability and conformational dynamics of DNA play pivotal roles in many biological milieus, such as in the site-specific binding of transcription factors to target...Full Text Available

2008-09-01

339

Modulation of Expression of the ToxR Regulon in Vibrio cholerae by a Member of the Two-Component Family of Response Regulators

A number of studies have examined the functional roles of individual muscles during normal walking, but few studies have examined which are the primary muscles that respond to changes in external...Full Text Available

2009-05-11

340

Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus Latent Membrane Protein-1

The ToxRS system in Vibrio cholerae plays a central role in the modulation of virulence gene expression in response to environmental stimuli. An integration of multiple signalling inputs...Full Text Available

1998-12-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

Modulation of Aire regulates the expression of tissue-restricted antigens

BackgroundCalcium signaling plays an important role in B lymphocyte survival and activation, and is critically dependent on the inositol-1,4,5-tris-phosphate-induced...Full Text Available

342

Modulation of ASK1 expression during overexpression of Trx and HSP70 in stressed fish liver mitochondria

AbstractIntrathymic expression of tissue-restricted antigens (TRAs) has been viewed as the key element in the induction of central tolerance and recently, a central role for the autoimmune...Full Text Available

2008-01-01

343

Mitochondrial function and redox control in the aging eye: Role of MsrA and other repair systems in cataract and macular degenerations

Mitochondrial heat shock protein 70 (mtHSP70) is found to play a primary role in cellular defense against physiological stress like exposure to environmental contaminants and helpful in the maintenance...Full Text Available

2009-09-01

344

Minocycline Synergizes with N-Acetylcysteine and Improves Cognition and Memory Following Traumatic Brain Injury in Rats

Oxidative stress occurs when the level of prooxidants exceeds the level of antioxidants in cells resulting in oxidation of cellular components and consequent loss of cellular function. Oxidative...Full Text Available

2009-02-01

345

Micturition in conscious rats with and without bladder outlet obstruction: role of spinal alpha 1-adrenoceptors.

BackgroundThere are no drugs presently available to treat traumatic brain injury (TBI). A variety of single drugs have failed clinical trials suggesting a role for drug combinations....Full Text Available

346

Metastasis-Inducing S100A4 and RANTES Cooperate in Promoting Tumor Progression in Mice

1. In normal rats and rats with bladder hypertrophy secondary to outflow obstruction, undergoing continuous cytometry, we examined the responses to the selective alpha 1-adrenoceptor antagonist doxazosin...Full Text Available

1996-03-01

347

Metabolic labeling and direct imaging of choline phospholipids in vivo

BackgroundThe tumor microenvironment has been described as a critical milieu determining tumor growth and metastases. A pivotal role of metastasis-inducing S100A4 in the development...Full Text Available

348

Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision

Choline (Cho)-containing phospholipids are the most abundant phospholipids in cellular membranes and play fundamental structural as well as regulatory roles in cell metabolism and signaling. Although...Full Text Available

2009-09-08

349

Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (NPY) gene

Using the photopigment melanopsin, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light to drive circadian clock resetting and pupillary constriction. We now...Full Text Available

2010-07-15

350

BackgroundNeuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and...Full Text Available

351

Manganese

Management of patients with newly diagnosed malignant primary brain tumors with a focus on the evolving role of temozolomide

Sources of manganese are identified. Uptake and distribution of manganese in plants and man are discussed, and the role of manganese in metabolism is described. The epidemiology of manganese toxicity is outlined, permissible air concentrations are listed, and the symptoms of manganese toxicity and deficiency are described. 555 references, 32 tables.

1973-01-01

352

Management and outcome of abdominal shotgun wounds. Trauma score and the role of exploratory laparotomy.

The prognosis for patients with newly diagnosed malignant gliomas remains poor; however there have been some recent advances in treatment that have generated optimism. Medical management usually includes...Full Text Available

2007-12-01

353

Mammalian end binding proteins control persistent microtubule growth

OBJECTIVE: The management and outcome of 138 abdominal shotgun wounds were examined over a 5-year period. SUMMARY BACKGROUND DATA: It has been proposed that exploratory laparotomy may be unnecessary...Full Text Available

1995-03-01

354

Malfunction of a Heimlich flutter valve causing tension pneumothorax: case report of a rare complication

End binding proteins (EBs) are highly conserved core components of microtubule plus-end tracking protein networks. Here we investigated the roles of the three mammalian EBs in controlling microtubule...Full Text Available

2009-03-09

355

Lymphocytes, neuropeptides, and genes involved in alopecia areata

BackgroundThoracic injuries play an important role in major trauma patients due to their high incidence and critical relevance. A serious consequence of thoracic trauma is pneumothorax,...Full Text Available

356

Long-lasting inhibition of presynaptic metabolism and neurotransmitter release by protein S-nitrosylation

Many lessons in autoimmunity — particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology — can be learned from the study of alopecia...Full Text Available

2007-08-01

357

Long-Lasting Adaptations of the NR2B-containing NMDA Receptors in the Dorsomedial Striatum Play a Crucial Role in Alcohol Consumption and Relapse

Nitric oxide (NO) and related reactive nitrogen species (RNS) play a major role in the pathophysiology of stroke and other neurodegenerative diseases. One of the poorly understood consequences...Full Text Available

2010-09-01

358

Local inhibition of nitric oxide generation in man reduces blood flow in finger pulp but not in hand dorsum skin.

A growing number of studies suggest that the development of compulsive drug seeking and taking depends on dorsostriatal mechanisms. We previously observed that ex vivo acute...Full Text Available

2010-07-28

359

Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2

1. Nitric oxide generation is important in the regulation of resistance vessel tone. Until now, however, there has been no evidence of such a role for basal generation of nitric oxide in the skin microcirculation...Full Text Available

1996-01-15

360

Lnk constrains myeloproliferative diseases in mice

In addition to its role in megakaryocyte production, signaling initiated by thrombopoietin (TPO) activation of its receptor, myeloproliferative leukemia virus protooncogene (c-Mpl, or Mpl), controls...Full Text Available

2008-08-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration

Hematopoietic stem and progenitor cell (HSPC) expansion is regulated by intrinsic signaling pathways activated by cytokines. The intracellular kinase JAK2 plays an essential role in cytokine signaling,...Full Text Available

2010-06-01

362

Lineage-specific co-evolution of the Egf receptor/ligand signaling system

BackgroundLipocalin 2 (Lcn2) is a bacteriostatic factor that may also modulate cellular function, however, little is known concerning the expression or role of Lcn2 in CNS inflammation....Full Text Available

363

Life Span Extension in Mice by Food Restriction Depends on an Energy Imbalance12

BackgroundThe epidermal growth factor receptor (Egfr) with its numerous ligands has fundamental roles in development, cell differentiation and physiology. Dysfunction of the receptor-ligand...Full Text Available

364

Lesions of the posterior bed nucleus of the stria terminalis eliminate opposite-sex odor preference and delay copulation in male Syrian hamsters: role of odor volatility and sexual experience

In this study, our main objective was to determine whether energy restriction (ER) affects the rate of oxygen consumption of mice transiently or lastingly and whether metabolic rate plays a role in...Full Text Available

2009-03-01

365

Lectin Binding of the Major Polar Tube Protein (PTP1) and its Role in Invasion

In Syrian hamsters (Mesocricetus auratus), the expression of reproductive behavior requires the perception of social odors. The behavioral response to these odors is mediated...Full Text Available

2010-08-01

366

Latent Tricuspid Valve Rupture after Motor Vehicle Accident and Routine Echocardiography in All Chest-Wall Traumas

... 2003)050[0600:LBOTMP]2.0.CO;2 Lectin Binding of the Major Polar Tube Protein (PTP1) ... PTP1. We, therefore, undertook a study ...

367

Large-scale Analysis of Thermo-stable, Mammalian Proteins Provides Insights into the Intrinsically Disordered Proteome

Blunt chest-wall trauma is common; however, resultant tricuspid valve rupture is rare and can be subtle in its presentation. Transthoracic echocardiography plays a key role in diagnosis.Herein,...Full Text Available

2009-01-01

368

Isolation and partial characterization of a specific alpha-fetoprotein receptor on human monocytes.

Intrinsically disordered proteins are predicted to be highly abundant and play broad biological roles in eukaryotic cells. In particular, by virtue of their structural malleability and propensity...Full Text Available

2009-01-01

369

Is There a Role for Patent Medicine Vendors in Tuberculosis Control in Southern Nigeria?

Since a large body of data has suggested a significant role for alpha-fetoprotein (AFP) in the regulation of the immune response at a number of levels, we examined the possibility of a specific receptor...Full Text Available

1992-10-01

370

Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis

Patent medicine vendors (PMVs) are a ubiquitous feature of the informal health sector in Nigeria. A previous study on healthcare-seeking behaviour of persons with chronic cough in southern Nigeria found...Full Text Available

2010-12-01

371

Investigating the spatial variability in incidence of coronary heart disease in the Gazel cohort: the impact of area socioeconomic position and mediating role of risk factors

AMP-activated-protein-kinase (AMPK) is a key sensor and regulator of cellular and whole-body energy metabolism and plays a key role in regulation of lipid metabolism. Since lipid metabolism...Full Text Available

2010-09-03

372

Intravascular ultrasound to guide the management of intracoronary thrombus: a Case Report

Study objectiveThe study aim was to improve our understanding of the relationships between contextual socioeconomic characteristics and coronary heart disease (CHD)...Full Text Available

2011-02-01

373

Intact A?-fibers up-regulate TRPA1 and contribute to cold hypersensitivity in neuropathic rats

Percutaneous coronary intervention can be associated with distal embolization of thrombotic material causing myocardial necrosis and infarction.We discuss the role of intravascular imaging to...Full Text Available

374

Influence of major histocompatibility complex genotype on mating success in a free-ranging reptile population

Mechanisms underlying cold hypersensitivity in neuropathic states are unclear. Recent data indicate both TRPM8 and TRPA1 play a role. In relation to TRPA1, there are reported increases in mRNA....Full Text Available

2008-06-26

375

Increased prevalence of antibodies to enteropathogenic Yersinia enterocolitica virulence proteins in relatives of patients with autoimmune thyroid disease

Major histocompatibility complex (MHC) genes are highly polymorphic components of the vertebrate immune system, which play a key role in pathogen resistance. MHC genes may also function as odour-related...Full Text Available

2009-05-07

376

Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus

Infections have been implicated in the pathogenesis of a number of autoimmune diseases, and Yersinia enterocolitica (YE) might play a role in the development of autoimmune thyroid disease...Full Text Available

2003-05-01

377

Increased degradation of MYPT1 contributes to the development of tolerance to nitric oxide in porcine pulmonary artery

To gain insight into ATP-binding cassette transporter A1 (ABCA1) function and its potential role in AD pathology, we analyzed the expression of the cholesterol transporter ABCA1...Full Text Available

2010-03-08

378

Immune-Based Therapies for Sarcoma

Myosin phosphatase target subunit 1 (MYPT1) is the regulatory subunit of myosin light chain phosphatase (MLCP). It plays a critical role in vasodilatation induced by cGMP-elevating agents such as nitric...Full Text Available

2010-07-01

379

Immune activation and IL-12 production during acute/early HIV infection in the absence and presence of highly active, antiretroviral therapy

Immunotherapy has shown promise in a number of tumor types, but its exact role in sarcoma remains to be defined. Advanced bone and soft tissue sarcomas are challenging diseases to treat with an unmet...Full Text Available

2011-01-01

380

Identification of Achaete-scute complex-like 1 (ASCL1) target genes and evaluation of DKK1 and TPH1 expression in pancreatic endocrine tumours

Suppressed IL-12 production and maladaptive immune activation, both of which are ameliorated by successful highly active antiretroviral therapy (HAART), are thought to play important roles in the immunopathogenesis...Full Text Available

2008-12-01

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381

Identification and validation of heavy metal and radionuclide hyperaccumulating terrestrial plant species. Quarterly technical progress report, March 20, 1995--June 20, 1995

BackgroundASCL1 role in pancreatic endocrine tumourigenesis has not been established. Recently it was suggested that ASCL1 negatively controls expression of the...Full Text Available

382

Identification and Characterization of Retinoid-Active Short-Chain Dehydrogenases/Reductases in Drosophila melanogaster

The biological accumulation of heavy metals and cesium, strontium, and uranium in plants is discussed. The role of nutrient deficiencies and foliar treatments of manganese and iron compounds is described.

1995-12-01

383

ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine

BackgroundIn chordates, retinoid metabolism is an important target of short-chain dehydrogenases/reductases (SDRs). It is not known whether SDRs play a role in retinoid...Full Text Available

2009-10-01

384

Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription

BackgroundAnimals carrying genetic mutations have provided powerful insights into the role of interstitial cells of Cajal (ICC) in motility. One classic model is...Full Text Available

2010-05-01

385

Human spumaretrovirus-related sequences in the DNA of leukocytes from patients with Graves disease.

Cellular hypertrophy is regulated by coordinated pro- and antigrowth machineries. Foxo transcription factors initiate an atrophy-related gene program to counter hypertrophic growth. This study was designed...Full Text Available

2008-09-01

386

Human Pol II promoter recognition based on primary sequences and free energy of dinucleotides

Viruses, and more particularly retroviruses, have been postulated to play a role in the pathogenesis of autoimmune diseases. In a search for spumaretrovirus infection markers, we screened a group of...Full Text Available

1992-11-01

387

Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence12

BackgroundPromoter region plays an important role in determining where the transcription of a particular gene should be initiated. Computational prediction of eukaryotic Pol II promoter...Full Text Available

388

High Outcrossing in the Annual Colonizing Species Ambrosia artemisiifolia (Asteraceae)

BACKGROUND: Although the importance of lymphatic function is well recognized, the lack of real-time imaging modalities limits our understanding of its role in many diseases. In a phase...Full Text Available

389

HPV16 E2 could act as down-regulator in cellular genes implicated in apoptosis, proliferation and cell differentiation

Background and AimsVariation in mating patterns may be particularly evident in colonizing species because they commonly experience wide variation in plant density. Here, the role...Full Text Available

2008-06-01

390

HCN polymers characterized by solid state NMR: Chains and sheets formed in the neat liquid

BackgroundHuman Papillomavirus (HPV) E2 plays several important roles in the viral cycle, including the transcriptional regulation of the oncogenes E6 and E7, the regulation of the...Full Text Available

391

Global protected area impacts

Hydrogen cyanide polymerizes readily under a variety of conditions and significant prebiotic roles have been suggested for these polymers due to the abundance of HCN in universe. However, the structures...Full Text Available

2009-04-07

392

German connections behind EFL's Zn-air

Protected areas (PAs) dominate conservation efforts. They will probably play a role in future climate policies too, as global payments may reward local reductions of loss of natural land cover. We estimate...Full Text Available

2011-06-07

393

Genome-wide linkage scan for contraction velocity characteristics of knee musculature in the Leuven Genes for Muscular Strength Study

This paper describes a new concept in zinc-air battery technology and provides and insight into the role of the German Post Office and its former chairman in its commercial promotion. (UK)

1994-10-01

394

Genetical approach to oxygen toxicity. [Saccharomyces cerevisiae

The torque-velocity relationship is known to be affected by ageing, decreasing its protective role in the prevention of falls. Interindividual variability in this torque-velocity relationship is partly...Full Text Available

2008-09-01

395

Genetic Susceptibility for Individual Cooperation Preferences: The Role of Monoamine Oxidase A Gene (MAOA) in the Voluntary Provision of Public Goods

The role of intermediate products of dioxygen reduction in cytotoxic effects ascribed to oxygen molecules was studied in vivo using various yeast mutants with changed response to oxygen stress. It has been documented that superoxide radical exerts its deleterious effects on yeast cells directly and the role of other oxygen species derived from it is hardly detectable. Yeast Saccharomyces cerevisiae, however, cannot be considered as a typical eukaryotic organism due to its inability of synthesizing polyunsaturated fatty acids (pufa). These fatty acids are known as main target molecules during oxidative stress and their peroxidation leads to cytotoxic effects. As fatty acid content could be easily manipulated in yeast, this organism was used to evaluate the contribution of pufa peroxidation process to the cytotoxic effects of oxygen. Results obtained show, that yeast cells containing linolenic acid as the main constituent of phospholipids are ...

1986-01-01

396

Gender and risk of autoimmune diseases: possible role of estrogenic compounds.

In the context of social dilemmas, previous research has shown that human cooperation is mainly based on the social norm of conditional cooperation. While in most cases individuals behave according...Full Text Available

397

From Rapid Place Learning to Behavioral Performance: A Key Role for the Intermediate Hippocampus

A striking common feature of many autoimmune diseases in humans and experimental animals, despite differences in pathology, is that females are highly susceptible to autoimmune conditions compared to...Full Text Available

1999-10-01

398

Food deprivation and the role of estradiol in mediating sexual behaviors in meadow voles

Rapid place encoding by hippocampal neurons, as reflected by place-related firing, has been intensely studied, whereas the substrates that translate hippocampal place codes into behavior have received...Full Text Available

2009-04-01

399

FIRST TRIMESTER BACTERIAL VAGINOSIS, INDIVIDUAL MICROORGANISM LEVELS AND RISK OF SECOND TRIMESTER PREGNANCY LOSS AMONG URBAN WOMEN

Female mammals are particularly sensitive to changes in food availability. The mechanisms that affect sexual behavior and food intake are closely related to one another; chief among the mechanisms...Full Text Available

2007-02-28

400

Excessive TV viewing and cardiovascular disease risk factors in adolescents. The AVENA cross-sectional study

ObjectiveTo examine the role of first trimester bacterial vaginosis (BV) and level of BV-associated microorganisms diagnosed using the Nugent’s Gram stain...Full Text Available

2007-11-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

Evidence for an association between TSH and IGF-1 receptors

BackgroundExcessive television (TV) viewing might play an important role in the development of cardiovascular disease (CVD). The aim of this study was to examine the independent...Full Text Available

402

Evaluation of support groups for women with breast cancer: importance of the navigator role

TSH receptor (TSHR) plays a central role in regulating thyroid function and is targeted by IgGs in Graves’ disease (GD-IgG). Whether TSHR is involved in the pathogenesis of thyroid associated...Full Text Available

2008-09-15

403

Evaluation of protector potential of extracts from Cymbopogon citratus, Maytenus ilicifolia, Baccharis genistelloides against the effects of stannous chloride: role of exonuclease III enzyme

BackgroundAt least some forms of breast cancer are increasingly being viewed as a chronic illness, where an emphasis is placed on meeting the various ongoing needs of people living...Full Text Available

404

Essential Role of Phox2b-Expressing Ventrolateral Brainstem Neurons in the Chemosensory Control of Inspiration and Expiration

Portuguese 2003 [1 p.] Brazil Soares, SF Melo, SF Costa, RF Silva, CR

2003-11-20

405

Epidemiologic studies of electric and magnetic fields and cancer: strategies for extending knowledge.

Phox2b-expressing neurons of the retrotrapezoid nucleus (RTN) located in the ventrolateral brainstem are sensitive to changes in PCO₂/pH, have excitatory projections...Full Text Available

2010-09-15

406

Environmental-induced acquisition of nuptial plumage expression: a role of denaturation of feather carotenoproteins?

Epidemiologic research concerning electric and magnetic fields in relation to cancer has focused on the potential etiologic roles of residential exposure on childhood cancer and occupational exposure...Full Text Available

1993-12-01

407

Environmental and yield aspects of heat provision

Several avian species show a bright carotenoid-based coloration during spring and following a period of duller coloration during the previous winter, despite carotenoids presumably being fully deposited...Full Text Available

2005-09-22

408

Enhancing Patient Safety by Reducing Healthcare-Associated Infections: The Role of Discovery and Dissemination

The advantages of district heating as an environmental-friendly and energy-saving technique are reviewed. The role of district heating as part of the Dutch national plan to reduce the emission of acidification and greenhouse gases by respectively 50 and 25 percent is clarified. 12 Tabs. (A.S.).

1994-01-01

409

Endogenous Nitric Oxide Protects Bacteria Against a Wide Spectrum of Antibiotics

Healthcare-associated infections (HAIs) take a major human toll on society and reduce public confidence in the healthcare system. The current convergence of scientific, public, and legislative...Full Text Available

2010-02-01

410

Encephalitis lethargica and the influenza virus. III. The influenza pandemic of 1918/19 and encephalitis lethargica: neuropathology and discussion*

Bacterial nitric oxide synthases (bNOS) are present in many Gram-positive species and have been demonstrated to synthesize NO from arginine in vitro and in vivo. However, the physiological role...Full Text Available

2009-09-11

411

Emergence of Switch-Like Behavior in a Large Family of Simple Biochemical Networks

This is the second of two papers which critically examine the relationship between the 1918/19 influenza pandemic and encephalitis lethargica (EL). The role of influenza in the etiology of EL...Full Text Available

2009-10-01

412

Electromagnetic and hadronic properties of tachyons

Bistability plays a central role in the gene regulatory networks (GRNs) controlling many essential biological functions, including cellular differentiation and cell cycle control. However, establishing...Full Text Available

2011-05-01

413

Electrochemical roles of precipitates on uniform corrosion and hydrogen pickup of zirconium alloys, 2. Roles on hydrogen pickup

After some preliminary comments on prevailing attitudes about tachyons, the author discusses superluminal transformations and the electromagnetic properties of tachyons. Their role in quantum mechanics is examined and a relativistically invariant hadron bootstrap model, which appears to account for many hadron states, is presented. (W.D.L).

414

Electrochemical roles of precipitates on uniform corrosion and hydrogen pickup of zirconium alloys, 2. Roles on hydrogen pickup

Substantial roles of precipitates such as Zr-Fe-Cr type intermetallic compounds on uniform corrosion and hydrogen pickup of zirconium alloys in pure water autoclave tests were investigated from an electrochemical point of view. In the previous paper, corrosion mechanism was elucidated by the anodic protection-precipitates degradation model. This paper describes the roles on hydrogen pickup. 633 K pure water autoclave test was performed on high purity zirconium, Zr-0.2Fe, Zr-0.2Cr, and Zr-0.1Fe-0.1Cr alloys. Hydrogen analysis after the corrosion test showed that hydrogen pickup ratio of Zr-0.2Fe alloy was about 80%. It was much higher than about 30% of pure Zr and about 10% of both Zr-0.2Cr and Zr-0.1Fe-0.1Cr alloys. Larger hydrogen content was introduced into Zr-0.2Fe alloy than the other ones by the cathodic hydrogen charging under coulombic equivalence. The precipitates at metal-oxide interface could act not only as cathodic sites in the ...

2000-08-01

415

Electrochemical roles of precipitates on uniform corrosion and hydrogen pickup of zirconium alloys, 1. Roles on corrosion

Substantial roles of precipitates such as Zr-Fe-Cr type intermetallic compounds on uniform corrosion and hydrogen pickup of zirconium alloys in pure water autoclave tests were investigated from an electrochemical point of view. In the previous paper, corrosion mechanism was elucidated by the anodic protection-precipitates degradation model. This paper describes the roles on hydrogen pickup. 633 K pure water autoclave test was performed on high purity zirconium, Zr-0.2Fe, Zr-0.2Cr, and Zr-0.1Fe-0.1Cr alloys. Hydrogen analysis after the corrosion test showed that hydrogen pickup ratio of Zr-0.2Fe alloy was about 80%. It was much higher than about 30% of pure Zr and about 10% of both Zr-0.2Cr and Zr-0.1Fe-0.1Cr alloys. Larger hydrogen content was introduced into Zr-0.2Fe alloy than the other ones by the cathodic hydrogen charging under coulombic equivalence. The precipitates at metal-oxide interface could act not only as cathodic sites in the ...

2000-08-01

416

Electrochemical roles of precipitates on uniform corrosion and hydrogen pickup of zirconium alloys, 1. Roles on corrosion

Substantial roles of precipitates such as Zr-Fe-Cr type intermetallic compounds on uniform corrosion and hydrogen pickup of zirconium alloys in pure water autoclave tests were investigated from an electrochemical point of view. This paper describes the roles on corrosion. A corrosion test on precipitate-containing and precipitate-free materials made from pure zirconium and a small quantity of iron and chromium, rest potential measurements on an intermetallic compound of Zr(FeCr){sub 2} and zirconium matrix, and a galvanic coupling test of those were performed. Results showed that corrosion behavior of zirconium alloys could be attributed to the electrochemical properties of intermetallic compounds precipitated in each alloy. Namely, the cathodic and anodic polarization characteristics were associated with anodic protection provided by the precipitates on the alloys and the precipitates degradation in the oxide films, respectively. The mechanism ...

2000-07-01

417

Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats

Substantial roles of precipitates such as Zr-Fe-Cr type intermetallic compounds on uniform corrosion and hydrogen pickup of zirconium alloys in pure water autoclave tests were investigated from an electrochemical point of view. This paper describes the roles on corrosion. A corrosion test on precipitate-containing and precipitate-free materials made from pure zirconium and a small quantity of iron and chromium, rest potential measurements on an intermetallic compound of Zr(FeCr)_2 and zirconium matrix, and a galvanic coupling test of those were performed. Results showed that corrosion behavior of zirconium alloys could be attributed to the electrochemical properties of intermetallic compounds precipitated in each alloy. Namely, the cathodic and anodic polarization characteristics were associated with anodic protection provided by the precipitates on the alloys and the precipitates degradation in the oxide films, respectively. The mechanism was ...

2000-07-01

418

Effects of Environmental Factors on Microbial Populations in Brackish Waters off the Southern Coast of Finland

Dysregulation of glutamate neurotransmission may play a role in cognitive deficits in schizophrenia. Manipulation of glutamate signaling using drugs acting at metabotropic glutamate receptors...Full Text Available

2010-08-10

419

Effect of orientation on the in vitro fracture toughness ofdentin: The role of toughening mechanisms

The roles played by environmental factors in seasonal changes in microbial populations were investigated in the Tvärminne area, off the southern coast of Finland. Surface-layer samples were...Full Text Available

1980-07-01

420

EFFECT OF AGE ON THE ROLE OF RHO-KINASE IN SHORT TERM PARTIAL BLADDER OUTLET OBSTRUCTION

A micro-mechanistic understanding of bone fracture thatencompasses how cracks interact with the underlying microstructure anddefines their local failure mode is lacking, despite extensive research nthe response of bone to a variety of factors like aging, loading, and/ordisease.

2003-01-28

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

421

EARLY BILATERAL SENSORY DEPRIVATION BLOCKS THE DEVELOPMENT OF COINCIDENT DISCHARGE IN RAT BARREL CORTEX

ObjectivesWe examined the expression of Rho Kinase (ROK) isoforms in young and old rabbit’s detrusor smooth muscles (SM) during the progression of short term...Full Text Available

2008-03-01

422

Dual Roles of Nrf2 in Cancer

Several theories have proposed a functional role for synchronous neuronal firing in generating the neural code of a sensory perception. Synchronous neural activity develops during a critical...Full Text Available

2009-02-25

423

Downregulation of Serum Gonadotropins is as Effective as Estrogen Replacement at Improving Menopause-Associated Cognitive Deficits

In response to oxidative stress, the transcription factor NF-E2-related factor 2 (Nrf2) controls the fate of cells through transcriptional upregulation of antioxidant response element (ARE)-bearing...Full Text Available

2008-01-01

424

Does school attendance reduce the risk of youth homelessness in Tanzania?

While estrogen (E2) is thought to play an important role in age-related cognitive decline, neuronal plasticity, as well as the pathogenesis of Alzheimer disease (AD), the mechanisms by which...Full Text Available

2010-02-01

425

Does physical anhedonia play a role in depression? A 20-year longitudinal study

BackgroundThis paper is based on data gathered from a 2006 survey of 1,098 "street children" in Northern Tanzania. It examines the role that school may play in preventing the migration...Full Text Available

426

Does Damage to DNA and Other Macromolecules Play a Role in Aging? If So, How?

BackgroundAnhedonia towards physical or sensory experiences (i.e., physical anhedonia) has most often been examined as a differentia of schizophrenia and not depression,...Full Text Available

2010-01-01

427

Do the Obese Have Lower Body Temperatures? A New Look at a Forgotten Variable in Energy Balance

One of the most pervasive ideas regarding the causes of aging is that longevity is constrained in large measure by damage to macromolecules. An increasing body of cellular and molecular data, generated...Full Text Available

2009-02-01

428

Divergent Regulation of Angiopoietin-1 and -2, Tie-2, and Thrombospondin-1 Expression by Estrogen in the Baboon Endometrium

Understanding the pathogenesis of obesity is now more important than ever, given the remarkable world-wide epidemic. This paper explores the potential role of core temperature in energy balance, and...Full Text Available

2009-01-01

429

Disruption of Putative Regulatory Loci in Listeria monocytogenes Demonstrates a Significant Role for Fur and PerR in Virulence

SUMMARYEstrogen has an important role in the reconstruction of a new vascular network in the endometrium during each menstrual cycle; however, the underlying mechanisms...Full Text Available

2010-05-01

430

Discovering Networks of Perturbed Biological Processes in Hepatocyte Cultures

The ability to adapt to adverse environmental conditions encountered in food and during host infection is a sine qua non for a successful Listeria monocytogenes infection. This ability...Full Text Available

2004-02-01

431

Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae.

The liver plays a vital role in glucose homeostasis, the synthesis of bile acids and the detoxification of foreign substances. Liver culture systems are widely used to test adverse effects of drugs...Full Text Available

432

Developmental Changes in Pituitary Adenylate Cyclase Activating Polypeptide Expression during the Perinatal Period: Possible Role in Fetal Gonadotroph Regulation

We have isolated a second gene (MLS1), which in addition to DAL7, encodes malate synthase from S. cerevisiae. Expression of the two genes is specific for their physiological roles in carbon and nitrogen...Full Text Available

1992-11-11

433

Development of rat CA1 neurones in acute Versus organotypic slices: role of experience in synaptic morphology and activity

Normal reproductive functioning may require secretion of LH independently of FSH. Variation in GnRH pulse frequency and inhibin negative feedback are mechanisms for differential gonadotropin regulation;...Full Text Available

2009-10-01

434

Development of circadian rhythmicity and light responsiveness in the rat suprachiasmatic nucleus: a study using the 2-deoxy[1-14C]glucose method.

Despite their wide use, the physiological relevance of organotypic slices remains controversial. Such cultures are prepared at 5 days postnatal. Although some local circuitry remains intact, they develop...Full Text Available

2003-07-01

435

Development of a Selective Modulator of Aryl Hydrocarbon (Ah) Receptor Activity that Exhibits Anti-Inflammatory Properties

The suprachiasmatic nucleus (SCN) of the hypothalamus is thought to play a critical role in circadian rhythm generation and entrainment to the light/dark cycle. In adult rats, the SCN shows a circadian...Full Text Available

1980-02-01

436

Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. However, the role of the AHR...Full Text Available

2010-05-17

437

Deposition and retention of inhaled fibres: effects on incidence of lung cancer and mesothelioma.

Large-conductance voltage- and calcium-activated potassium (BK) channels have been shown to play a role in detrusor overactivity (DO). The goal of this study was to determine whether bladder outlet...Full Text Available

2010-06-01

438

Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence

A review of the literature on chronic inhalation studies in which rats were exposed to mineral fibres at known fibre number concentrations was undertaken to examine the specific roles of fibre length...Full Text Available

1994-12-01

439

Deglutathionylation of 2-Cys Peroxiredoxin Is Specifically Catalyzed by Sulfiredoxin*

The Gram-negative bacterium Francisella tularensis is the causative agent of tularemia. Interest in this zoonotic pathogen has increased due to its classification as a category A agent...Full Text Available

2006-08-22

440

DOD (Department of Defense) Acquisition: Case Study of the MILSTAR (Military Strategic and Tactical Relay) Satellite Communications System.

Reversible protein glutathionylation plays a key role in cellular regulation and cell signaling and protects protein thiols from hyperoxidation. Sulfiredoxin (Srx), an enzyme that catalyzes the reduction...Full Text Available

2009-08-28

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase

The study of the Military Strategic and Tactical Relay (MILSTAR) program focuses on the role of the program manager and contracting officer in developing the acquisition strategy.

1986-01-01

442

Cyberpharmacies and the role of the US Food And Drug Administration

CDC7 is an essential gene required for DNA replication in Saccharomyces cerevisiae. Cdc7p homologs have recently been identified in vertebrates, but their role in DNA...Full Text Available

1999-03-16

443

Current Role and Future Perspectives of Magnetic Resonance Spectroscopy in Radiation Oncology for Prostate Cancer

The sale of consumer products over the Internet has grown rapidly, including the sale of drugs. While the growth in online drug sales by reputable pharmacies is a trend that may provide benefits to...Full Text Available

444

Crystallization and preliminary X-ray analysis of human liver ?-enolase

Prostatic neoplasms are not uniformly distributed within the prostate volume. With recent developments in three-dimensional intensity-modulated and imageguided radiation therapy, it is possible to treat...Full Text Available

2007-06-01

445

Critical nucleus size for disease-related polyglutamine aggregation is repeat length dependent

Enolase is a multifunctional enzyme that plays important roles in many biological and disease processes. α-Enolase from human liver (hENO1) was expressed as a soluble protein and purified by...Full Text Available

446

Computing needs of the superconducting super collider

Since polyglutamine (polyQ) aggregate formation has been implicated as playing an important role in expanded CAG repeat diseases, it is important to understand the biophysics underlying the...Full Text Available

2011-03-01

447

Computational approaches to discovering semantics in molecular biology

Following a brief description of the SSC, the computing needs are discussed for both the accelerator design and the experimentation. The computing power required is considerably beyond that being used at present facilities, and parallel processing is expected to play an important role in supplying these needs.

1984-01-01

448

Complexity of the microRNA repertoire revealed by next-generation sequencing

One of the central questions of molecular biology is the discovery of the semantics of DNA. This discovery relies in a critical way on a variety of expensive computations. In order to solve these computations, both parallel computers and special-purpose hardware play a major role.

1989-07-01

449

Comparing and Contrasting the Roles of AMPK and SIRT1 in Metabolic Tissues

MicroRNAs (miRNAs) have been implicated to play key roles in normal physiological functions, and altered expression of specific miRNAs has been associated with a number of diseases. It is of great interest...Full Text Available

2010-11-01

450

Comparative transcripts profiling reveals new insight into molecular processes regulating lycopene accumulation in a sweet orange (Citrus sinensis) red-flesh mutant

The ability to adapt and respond to nutrients is an ancient cellular function, conserved from unicellular to the most complex multicellular organisms, including mammals. Mammals adapt to changes...Full Text Available

2008-12-01

451

Chronobiological analysis and mass spectrometric characterization of pigment-dispersing factor in the cockroach Leucophaea maderae

BackgroundInterest in lycopene metabolism and regulation is growing rapidly because accumulative studies have suggested an important role for lycopene in human health promotion....Full Text Available

452

Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons

Pigment-dispersing factor (PDF) is a neuropeptide that plays a prominent role in the circadian clock of several insects. The cockroach Leucophaea maderae...Full Text Available

453

China pursues major role in particle physics

The mitogen-activated protein kinase/extracellular regulated kinase (MAPK/ERK) pathway plays a key role in mediating estrogen actions in the brain and neuronal sensitization during inflammation....Full Text Available

2009-12-29

454

CERN Multimedia

Mao Zedong dreamed of splitting an electron; this was no idle diversion. According to natural dialectics, which formed the philosophical underpinnings of Marxism, the entire universe, from top to bottom, was seething with tension and change. (1 page)

2006-01-01

455

Chemoprevention of Nonmelanoma Skin Cancer With Celecoxib: A Randomized, Double-Blind, Placebo-Controlled Trial

Characterizing and estimating rice brown spot disease severity using stepwise regression, principal component regression and partial least-square regression*

BackgroundPreclinical studies indicate that the enzyme cyclooxygenase 2 plays an important role in ultraviolet-induced skin cancers. We evaluated the efficacy and safety of celecoxib,...Full Text Available

2010-12-15

456

Changes in the surface fine structure of ependyma of the rat third ventricle following operative leakage of cerebrospinal fluid.

Detecting plant health conditions plays a key role in farm pest management and crop protection. In this study, measurement of hyperspectral leaf reflectance in rice crop (Oryzasativa...Full Text Available

2007-10-01

457

Caveolin-1 as a Novel Indicator of Wound-Healing Capacity in Aged Human Corneal Epithelium

The role of the ventricular ependyma in the elaboration of cerebrospinal fluid under resting conditions is well documented. In an attempt to elucidate its response to cerebrospinal fluid leakage, male...Full Text Available

1985-01-01

458

Calcium Effects on Stomatal Movement in Commelina communis L. ¹

Excess caveolin-1 has been reported to play a role in age-dependent hyporesponsiveness to growth factors in vitro. Therefore, we hypothesized that caveolin-1–dependent hyporesponsiveness...Full Text Available

2010-11-01

459

CRF receptors in the nucleus accumbens modulate partner preference in prairie voles

Stomatal movements depend on both ion influx and efflux; attainment of steady state apertures reflects modulation of either or both processes. The role of Ca²⁺ in those two processes was...Full Text Available

1988-07-01

460

Breast Cancer Diagnosis Using a Microfluidic Multiplexed Immunohistochemistry Platform

Recent evidence suggests a role for corticotropin-releasing factor (CRF) in the regulation of pair bonding in prairie voles. We have previously shown that monogamous and non-monogamous vole...Full Text Available

2007-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

Blowing in the Wind: Unanchored Patient Information Work during Cancer Care

BackgroundBiomarkers play a key role in risk assessment, assessing treatment response, and detecting recurrence and the investigation of multiple biomarkers may also prove useful...Full Text Available

462

Bacterial Competition for Human Nasal Cavity Colonization: Role of Staphylococcal agr Alleles

Patients do considerable information work. Technologies that help patients manage health information so they can play active roles in their health-care, such as personal health records, provide...Full Text Available

2010-01-01

463

Auxin Biosynthesis during Seed Germination in Phaseolus vulgaris¹

We examined the bacterial aerobic nasal flora of 216 healthy volunteers to identify potential competitive interactions among different species, with special emphasis on the influence of staphylococcal...Full Text Available

2003-01-01

464

Astrocyte-Derived Vascular Endothelial Growth Factor Stabilizes Vessels in the Developing Retinal Vasculature

The relative roles of de novo biosynthesis of indoleacetic acid (IAA) and IAA conjugates stored in mature seeds (Phaseolus vulgaris L.) in supplying auxin to germinating bean seedlings...Full Text Available

1992-09-01

465

Association of Protein Phosphatase 1?₁ with Spinophilin Suppresses Phosphatase Activity in a Parkinson Disease Model*

Vascular endothelial growth factor (VEGF) plays a critical role in normal development as well as retinal vasculature disease. During retinal vascularization, VEGF is most strongly expressed by not yet...Full Text Available

466

Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women

Sustained nigrostriatal dopamine depletion increases the serine/threonine phosphorylation of multiple striatal proteins that play a role in corticostriatal synaptic plasticity, including Thr²⁸⁶...Full Text Available

2008-05-23

467

Association Study of Serine Racemase Gene with Methamphetamine Psychosis

Background and aims: Serotonin (5-hydroxtryptamine, 5-HT) is an important factor in gut function, playing key roles in intestinal peristalsis and secretion, and in sensory...Full Text Available

2004-10-01

468

Assessing the Left Ventricular Systolic Function at the Bedside: The Role of Transpulmonary Thermodilution-Derived Indices

Experimental studies have demonstrated that not only dopaminergic signaling but also glutamatergic/NMDA receptor signaling play indispensable roles in the development of methamphetamine psychosis. Our...Full Text Available

2011-03-01

469

Arabidopsis and Tobacco SUPERMAN regulate hormone signalling and mediate cell proliferation and differentiation

Evaluating the systolic function of the left ventricle (LV) is important in the hemodynamic management of the critically ill patients with circulatory failure. Echocardiography is considered the standard...Full Text Available

2011-01-01

470

Antibodies to synthetic peptides from the tubulin regulatory domain interact with tubulin and microtubules.

Arabidopsis thaliana SUPERMAN (SUP) plays an important role during flower development by maintaining the boundary between stamens and carpels in the inner two whorls....Full Text Available

2011-01-01

471

Anti-Apoptotic Genes in the Survival of Monocytic Cells During Infection

The carboxyl-terminal region of tubulin alpha and beta subunits plays a major role in regulating its assembly into microtubules and constitutes an essential domain for the selective interaction of microtubule-associated...Full Text Available

1988-09-01

472

Angiotensin II Promotes Development of the Renal Microcirculation through AT₁ Receptors

Macrophages are cells of the immune system that protect organisms against invading pathogens by fulfilling critical roles in innate and adaptive immunity and inflammation. They originate from circulating...Full Text Available

2009-08-01

473

Analysis of Quantitative Interactions between Two Species of Arbuscular Mycorrhizal Fungi, Glomus mosseae and G. intraradices, by Real-Time PCR

Pharmacologic or genetic deletion of components of the renin-angiotensin system leads to postnatal kidney injury, but the roles of these components in kidney development are unknown. To test the hypothesis...Full Text Available

2010-03-01

474

Amygdala projections to central amygdaloid nucleus subdivisions and transition zones in the primate

Arbuscular mycorrhizal fungi (AMF) are obligate biotrophs, known to play an important role in ecological processes. Conventional light microscopy is the most common method used to detect their presence...Full Text Available

2006-06-01

475

Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network

In rats and primates, the central nucleus of the amygdala (CeN) is most known for its role in responses to fear stimuli. Recent evidence also shows that the CeN is required for directing attention...Full Text Available

2009-03-17

476

A remarkable discovery of recent years is that, despite the complexity of ageing, simple genetic interventions can increase lifespan and improve health during ageing in laboratory animals. The pathways...Full Text Available

2011-05-01

477

Affective and Personality Risk and Cognitive Mediators of Initial Adolescent Alcohol Use*

The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity. Apart from its role as ...Full Text Available

478

Advanced MRI Methods for Assessment of Chronic Liver Disease

Objective:This study examined the role of cognitive factors—such as expectancies regarding the consequences of not drinking and perceptions of peer drinking—in...Full Text Available

2010-07-01

479

Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses

MRI plays an increasingly important role for assessment of patients with chronic liver disease. MRI has numerous advantages, including lack of ionizing radiation and the possibility of performing...Full Text Available

2009-07-01

480

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis*

BackgroundThe successful interaction of bacterial pathogens with host tissues requires the sensing of specific chemical and physical cues. The human gut contains a huge number of...Full Text Available

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

481

Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1? Have an Antagonistic Connection

Adipocyte death has been reported in both obese humans and rodents. However, its role in metabolic disorders, including insulin resistance, hepatic steatosis, and inflammation associated with obesity...Full Text Available

2010-01-29

482

Abnormalities of GATA-1 in Megakaryocytes from Patients with Idiopathic Myelofibrosis

The tumor suppressor adenomatous polyposis coli (APC) is mutated in the majority of colorectal cancers and is best known for its role as a scaffold in a Wnt-regulated protein complex that determines...Full Text Available

2010-11-01

483

Abciximab: a reappraisal of its use in coronary care

The abnormal megakaryocytopoiesis associated with idiopathic myelofibrosis (IM) plays a role in its pathogenesis. Because mice with defective expression of transcription factor GATA-1 (GATA-1^low...Full Text Available

2005-09-01

484

A simple method to systematically study oxidatively-modified proteins in biological samples and its applications

Platelet reactivity plays a pivotal role in the pathogenesis of ischemic adverse events during and after acute coronary syndromes (ACS), and percutaneous coronary intervention (PCI). Glycoprotein (GP)...Full Text Available

2008-03-01

485

A role of ygfZ in the Escherichia coli response to plumbagin challenge

Increased oxidative stress with elevated levels of reactive oxygen and nitrogen species (ROS/RNS) plays an important role in the pathophysiology of many disease states. Increased ROS/RNS can...Full Text Available

2010-01-01

486

A possible role of decreased relaxation mediated by beta-adrenoceptors in bladder outlet obstruction by benign prostatic hyperplasia.

Plumbagin is found in many herbal plants and inhibits the growth of various bacteria. Escherichia coli strains are relatively resistant to this drug. The mechanism of resistance is...Full Text Available

487

A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention

1. To explore mechanisms of urinary obstruction in benign prostatic hyperplasia (BPH), the features of contraction and relaxation in human hyperplastic and non-hyperplastic (control) prostatic tissues...Full Text Available

1992-11-01

488

A novel approach for predicting the uptake and toxicity of metallic and metalloid ions

BackgroundCentrosome aberrations can cause genomic instability and correlate with malignant progression in common human malignancies such as breast and prostate cancer. Deregulation...Full Text Available

489

A non-radioactive dot-blot assay for transglutaminase activity

Electrostatic nature of plant plasma membrane (PM) plays significant roles in the ion uptake and toxicity. Electrical potential at the PM exterior surface (ψ₀^o) influences...Full Text Available

2011-03-01

490

A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors

Aberrant transglutaminase (TG) activity has been implicated in the pathology of numerous diseases including Huntington disease and Alzheimer disease. To fully characterize the role of TGs in...Full Text Available

2009-07-01

491

A haplotype map of the human genome

The ventromedial hypothalamus (VMH) plays a central role in the regulation of the female reproductive behavior lordosis, a behavior dependent upon the sequential activation of receptors for the ovarian...Full Text Available

2000-11-07

492

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells

Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million...Full Text Available

2005-10-27

493

A direct role for serum albumin in the cellular uptake of long-chain fatty acids.

KLF1 regulates a diverse suite of genes to direct erythroid cell differentiation from bipotent progenitors. To determine the local cis-regulatory contexts and transcription factor networks...Full Text Available

2010-08-01

494

A Strong Case for Viral Genetic Factors in HIV Virulence

The interaction of long-chain fatty acids with cells is important for their uptake and metabolism, as well as their involvement in signalling processes. The majority of long-chain fatty acids circulating...Full Text Available

1995-05-15

495

A Review of the Biochemistry, Metabolism and Clinical Benefits of Thiamin(e) and Its Derivatives

HIV infections show great variation in the rate of progression to disease, and the role of viral genetic factors in this variation had remained poorly characterized until recently. Now a series of four...Full Text Available

496

A Predictive Risk Probability Approach for Microarray Data with Survival as an Endpoint

Thiamin(e), also known as vitamin B1, is now known to play a fundamental role in energy metabolism. Its discovery followed from the original early research on the ‘anti-beriberi factor’...Full Text Available

2006-03-01

497

A Population-Based, Longitudinal Study of Erectile Dysfunction and Future Coronary Artery Disease

Gene expression profiling has played an important role in cancer risk classification and has shown promising results. Since gene expression profiling often involves determination of a set of...Full Text Available

2008-01-01

498

A Dominant Role for the Immunoproteasome in CD8⁺ T Cell Responses to Murine Cytomegalovirus

OBJECTIVE: To assess the association between erectile dysfunction (ED) and the long-term risk of coronary artery disease (CAD) and the role of age as a modifier of this association.PARTICIPANTS...Full Text Available

2009-02-01

499

A Conserved Role for Phosphoinositide-3-Kinase but Not Akt Signaling in Mitochondrial Adaptations that Accompany Physiological Cardiac Hypertrophy

Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates...Full Text Available

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