Science.gov (United States)

Seed dormancy is an adaptive mechanism and an important agronomic trait. Temperature during seed development strongly affects seed dormancy in wheat (Triticum aestivum) with lower temperatures producing higher levels of seed dormancy. To identify genes important for seed dormancy, we used a wheat microarray to analyze gene expression in embryos from mature seeds grown at lower and higher temperatures. We found that a wheat homolog of MOTHER OF FT AND TFL1 (MFT) was upregulated after physiological maturity in dormant seeds grown at the lower temperature. In situ hybridization analysis indicated that MFT was exclusively expressed in the scutellum and coleorhiza. Mapping analysis showed that MFT on chromosome 3A (MFT-3A) colocalized with the seed dormancy quantitative trait locus (QTL) QPhs.ocs-3A.1. MFT-3A expression levels in a dormant cultivar used for the detection of the QTL were higher after physiological maturity; this increased expression correlated with a single nucleotide ...

UK PubMed Central (United Kingdom)

Molecular Misreading (MM) is the inaccurate conversion of genomic information into aberrant proteins. For example, when RNA polymerase II transcribes a GAGAG motif it synthesizes at low frequency RNA...Full Text Available

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Candoxin (PDB #1JGK), a three-finger neurotoxin from Bungarus candidus venom, inhibits post-synaptic neuromuscular and neuronal alpha7nACh-receptors, and induces delayed cell-death throughout the glial population. When applied to cultured human glial cell lines, candoxin (CDX) induced cell death in a concentration (EC(50) approximately 1muM) and time dependent manner. Results of TUNEL-histochemistry further confirm CDX-induced brain (hippocampus, frontal cortex, and temporal regions) damage when administered intracerebroventricularly (i.c.v) in adult mice. In this study, we explored differential gene expression profiles following exposure of human glial (Hs 683) cell lines to CDX at various time intervals using Affymetrix-GeneChips. By means of MAS and GeneSpring analyses, 105 genes whose expression was significantly (P<0.01) altered by at least 3-fold were selected. Results of the genome analysis reveal that the potential role of CDX at molecular level involves the regulation of ...

UK PubMed Central (United Kingdom)

The ubiquitin–proteasome pathway is the principal system for extralysosomal protein degradation in eukaryotic cells, and is essential for the regulation and maintenance of basic cellular processes,...Full Text Available

International Nuclear Information System (INIS)

The Risk Evaluation System (RES) is an integrated approach to determining safeguards and security effectiveness and risk. RES combines the planning and technical analysis into a format that promotes an orderly development of protection strategies, planning assumptions, facility targets, vulnerability and risk determination, enhancement planning, and implementation. In addition, the RES computer database program enhances the capability of the analyst to perform a risk evaluation of the facility. The computer database is menu driven using data input screens and contains an algorithm for determining the probability of adversary defeat and risk. Also, base case and adjusted risk data records can be maintained and accessed easily.

Energy Technology Data Exchange (ETDEWEB)

Three abiotic systems are described that catalyze the reductive dehalogenation of heavily halogenated environmental pollutants, including carbon tetrachloride, trichloroethene, and perchloroethene. These systems include (a) an electrolytic reactor in which the potential on the working electrode (cathode) is fixed by using a potentiostat, (b) a light-driven system consisting of a semiconductor and (covalently attached) macrocycle that can accept light transmitted via an optical fiber, and a light-driven, two-solvent (isopropanol/acetone) system that promotes dehalogenation reactions via an unknown mechanism. Each is capable of accelerating reductive dehalogenation reactions to very high rates under laboratory conditions. Typically, millimolar concentrations of aqueous-phase targets can be dehalogenated in minutes to hours. The description of each system includes the elements of reaction mechanism (to the extent known), ...

International Nuclear Information System (INIS)

One of the characteristic safety features of a pool type research reactor is a safety flapper valve. The valve enables natural convection cooling mechanism in one of the following events. (a) Opening flapper valve promote decay heat removal following reactor's shutdown. (b) Also the valve is gravity driven. There is a possibility that the valve fails to open when it is required to do so. In the present paper the cooling characteristics of the core are analyzed for this event. A steady state study was performed for 5 MW power and 18 FE following a reactor shutdown. It is shown that enough margin exists to assure adequate reactor core cooling should the safety flapper valve fails to open. (authors)

UK PubMed Central (United Kingdom)

Environmental and occupational exposures to heavy metals such as methylmercury (MeHg) and cadmium (Cd) pose significant health risks to humans, including neurotoxicity. The underlying mechanisms of...Full Text Available

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The R&D in satellite communications in Korea has been driven mainly by KCC (Korea Communications Commission) but in a small scale compared to Korea space development program organized by MEST (Ministry of Education, Science and Technology). Public and civilian satcom sector R&D has been led mainly by ETRI with small/medium companies contrary to rare investment in private sector while military sector R&D has been orchestrated by ADD with defense industry. By the COMS (Communication, Ocean and Meteorological Satellite) experimental Ka-band payload, Korea pursues a space qualification of own technology for national infrastructure evolution as well as industrialization of space R&D results. Once COMS launched and space qualified in 2009, subsequent application experiments and new technology R&D like UHDTV will entail service and industry promotion. The payload technology is expected for the next Korean commercial satellites or ...

Norwegian Open Research Archives (NORA)

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A methodology and toolkit are described which enable the automated metadata-driven creation of datamarts from clinical data warehouses. The software uses schema-to-schema transformation driven by an...Full Text Available

KoreaScience (Korea)

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Abstract The heterotetrameric K++-channel KCNQ1/KCNE1 is expressed in heart, skeletal muscle, liver and several epithelia including the renal proximal tubule. In the heart, it contributes to the repolarization of cardiomyocytes. The repolarization is impaired in ischemia. Ischemia stimulates the AMP-activated protein kinase (AMPK), a serine/threonine kinase, sensing energy depletion and stimulating several cellular mechanisms to enhance energy production and to limit energy utilization. AMPK has previously been shown to downregulate the epithelial Na++ channel ENaC, an effect mediated by the ubiquitin ligase Nedd4-2. The present study explored whether AMPK regulates KCNQ1/KCNE1. To this end, cRNA encoding KCNQ1/KCNE1 was injected into Xenopus oocytes with and without additional injection o...

UK PubMed Central (United Kingdom)

Promoters are important regulatory elements that contain the necessary sequence features for cells to initiate transcription. To functionally characterize a large set of human promoters, we measured...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The Sunshine Project of Japan was inaugurated in 1974. Since 1980 it has been promoting priority projects such as coal liquefaction. Japan is now promoting the basic and applied research that underpins this development and is increasing the efficiency of technical development. With regard to risk dispersion, the expansion of international cooperation such as the IEA is being promoted.

Science.gov (United States)

Spike-timing-dependent plasticity (STDP), a form of Hebbian plasticity, is inherently stabilizing. Whether and how GABAergic inhibition influences STDP is not well understood. Using a model neuron driven by converging inputs modifiable by STDP, we determined that a sufficient level of inhibition was critical to ensure that temporal coherence (correlation among presynaptic spike times) of synaptic inputs, rather than initial strength or number of inputs within a pathway, controlled postsynaptic spike timing. Inhibition exerted this effect by preferentially reducing synaptic efficacy, the ability of inputs to evoke postsynaptic action potentials, of the less coherent inputs. In visual cortical slices, inhibition potently reduced synaptic efficacy at ages during but not before the critical period of ocular dominance (OD) plasticity. Whole-cell recordings revealed that the amplitude of unitary IPSCs from parvalbumin positive (Pv+) interneurons to pyramidal neurons ...

UK PubMed Central (United Kingdom)

Homologous to bacteriorhodopsin and even more to proteorhodopsin, xanthorhodopsin is a light-driven proton pump that, in addition to retinal, contains a noncovalently bound carotenoid with a function...Full Text Available

KoreaScience (Korea)

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... Examples are when carbon dioxide and volcanic ash emitted into the atmosphere by volcanic eruptions ...

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Subcritical source-driven noise measurements are simultaneous Rossia and randomly pulsed neutron measurements that provide measured quantities that can be related to the subcritical neutron multiplication factor. In fact, subcritical source-driven noise measurements should be performed in lieu of Rossia measurements because of the additional information that is obtained from noise measurements such as the spectral ratio and the coherence functions. The basic understanding of source-driven noise analysis measurements can be developed from a point reactor kinetics model to demonstrate how the measured quantities relate to the subcritical neutron multiplication factor.

Science.gov (United States)

Cytosine methylation in DNA is a major epigenetic signal, and plays a central role in propagating chromatin status during cell division. However the mechanistic links between DNA methylation and histone methylation are poorly understood. A multi-domain protein UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is required for DNA CpG maintenance methylation at replication forks, and mouse UHRF1-null cells show enhanced susceptibility to DNA replication arrest and DNA damaging agents. Recent data demonstrated that the SET and RING associated (SRA) domain of UHRF1 binds hemimethylated CpG and flips 5-methylcytosine out of the DNA helix, whereas its tandom tudor domain and PHD domain bind the tail of histone H3 in a highly methylation sensitive manner. We hypothesize that UHRF1 brings the two components (histones and DNA) carrying appropriate markers (on the tails of H3 and hemimethylated CpG sites) ready to be assembled into a nucleosome after ...

International Nuclear Information System (INIS)

The inducible transcription factor NF-#kappa#B regulates divergent signaling pathways including inflammatory response and cancer development. Selective inhibitors for NF-#kappa#B signaling are potentially useful for treatment of inflammation and cancer. NF-#kappa#B is canonically activated by preferential disposal of its inhibitory protein; I#kappa#B, which suppresses the nuclear translocation of NF-#kappa#B. I#kappa#B#alpha# (a major member of I#kappa#B family proteins) is phosphorylated with an I#kappa#B kinase (IKK) and subsequently polyubiquitylated by SCF"#beta#"T"r"C"P"1 ubiquitin-ligase in the presence of E1 and E2 prior to proteasomal degradation. Here, we describe a novel inhibitor termed GS143, which suppressed I#kappa#B#alpha# ubiquitylation, but not I#kappa#B#alpha# phosphorylation, MDM2-directed p53 ubiquitylation, and proteasome activity in vitro. GS143 markedly suppressed the destruction of I#kappa#B#alpha# stimulated by TNF#alpha# and a set of ...

UK PubMed Central (United Kingdom)

We have previously reported the construction and characterization of an autonomously replicating plasmid in Trypanosoma brucei. In this plasmid the procyclic acidic repetitive protein (PARP) gene promoter...Full Text Available

UK PubMed Central (United Kingdom)

A continuous stream of activating and repressing signals is processed by the transcription complex paused at the promoter of the c-myc proto-oncogene. The general transcription factor...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo study informal skill transfer via staff networks as a complement to formal training among afterschool childcare providers implementing a health promotion...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundWith rates of childhood obesity increasing, physical activity (PA) promotion especially in young children has assumed greater importance. Given the limited effectiveness...Full Text Available

UK PubMed Central (United Kingdom)

ObjectivesThis feasibility study developed and pilot tested an intervention to: (1) increase knowledge about prostate cancer (CaP) screening; and (2) promote self-efficacy...Full Text Available

KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

Promoted antimony phosphate oxide complexes are excellent catalysts for the ammoxidation of methanol to HCN especially at high methanol throughputs.

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The proposed short wavelength coherent light source driven by the SLAC 3 km linac might be used to induce transitions between nuclear isomeric states. If an isotope were found with energetically adjacent isomeric states, one short-lived and one long-lived, and it were possible to separate and concentrate the long-lived species, and other nuclear and solid-state parameters were favorable, it might be possible to convert sufficient population to the short-lived state to realize [gamma]-ray lasing. Even if the x-ray intensity were insufficient, study of such driven transitions would be quite valuable.

Science.gov (United States)

single star evolution. To understand the evolution of massive stars and their role in shaping the galaxy, understanding of the distribution of ...

Science.gov (United States)

Evolution in Space Radio Telescopes Reveal Youngest Stellar Corpse Gas Clouds in Whirlpool Galaxy Yield Important Clues Supporting Theory on Spiral Arms Starbust-driven Winds...

British Library Electronic Table of Contents (United Kingdom)

Turbulent shear flows on shallow continental shelves (here shallow means that the interaction with the solid, no-slip bottom is important) are of great importance because tide- and wind-driven flows on the shelf are drivers of the transfer of momentum, heat, and mass (gas) across the air?sea interface. These turbulent flows play an important role because vertical mixing and current are vectors for the transport of sediment and bioactive material on continental shelves. Understanding the dynamics of this class of flows presents complications because of the presence of a free surface and also because the flow can be driven by a pressure gradient (a tidal current), a stress at the free surface (a wind-driven current), or a combination of both. In addition, the flow can be modified by the pres...

Science.gov (United States)

... Wheeled Vehicle) equipped with a MILSTAR terminal was driven ... textbooks including Ronald W. Wolff, Stochastic Modeling and The ... Queue Length ...

Science.gov (United States)

Fire-driven deforestation is the major source of carbon emissions from Amazonia. Recent expansion of mechanized agriculture in forested regions of Amazonia ...

Energy Technology Data Exchange (ETDEWEB)

In this work, a comprehensive model has been developed for the absorption of carbon dioxide into promoted hot potassium carbonate solution. The model, which is based on penetration theory, incorporates an extensive set of important reactions and takes into account the coupling between mass transfer and chemical kinetics. The penetration theory provides an appropriate absorption rate and enhancement factor for the chemical absorption. Operating data for carbon dioxide absorption into DEA-hot potassium carbonate solution has been compared with model predictions. The impact of parameters such inlet temperature of lean solution, promoter concentration, liquid split fraction, hot feed location and type of promoter on the performance of a split-flow absorber have been examined. The use of other promoters is an efficient way to enhance the carbon dioxide absorption, which has been discussed in this paper.

Energy Technology Data Exchange (ETDEWEB)

Since 1998, The Pennsylvania State University successfully managed the Consortium for Premium Carbon Products from Coal (CPCPC), which was a vehicle for industry-driven research on the promotion, development, and transfer of innovative technologies on premium carbon products from coal to the U.S. industry. The CPCPC was an initiative led by Penn State, its cocharter member West Virginia University (WVU), and the U.S. Department of Energy's (DOE) National Energy Technology Laboratory (NETL), who also provided the base funding for the program, with Penn State responsible for consortium management. CPCPC began in 1998 under DOE Cooperative Agreement No. DE-FC26-98FT40350. This agreement ended November 2004 but the CPCPC activity continued under cooperative agreement No. DE-FC26-03NT41874, which started October 1, 2003 and ended December 31, 2010. The objective of the second agreement was to continue the successful operation of the CPCPC. ...

Energy Technology Data Exchange (ETDEWEB)

This investigation concerns the nonlinear dynamics of heat transfer from a surface using an upstream eddy promoter. A numerical model is developed for the coupled fluid flow and heat transfer process based on a modified MacCormack scheme. Numerical simulations are carried out to determine the response and heat transfer enhancement due to the promoter. The average heat transfer from a cavity floor is seen to be increased by a factor of approximately five over the unpromoted'' flow. Another interesting feature of the study is the nonlinear viscous flow dynamics from the cylinder-wall interaction which differ significantly from the familiar cylinder-free stream patterns.

UK PubMed Central (United Kingdom)

In this article, transhumanism is considered to be a quasi‐medical ideology that seeks to promote a variety of therapeutic and human‐enhancing aims. Moderate conceptions are distinguished...Full Text Available

DEFF Research Database (Denmark)

Udgivelsesdato: 2008-null

Science.gov (United States)

Recent Reviews in Carcinogenesis is a service of the International Cancer Research Data Bank (ICRDB) Program of the National Cancer Institute, intended to facilitate and promote the exchange of information between cancer scientists. It contains abstracts ...

UK PubMed Central (United Kingdom)

While autophagy has been shown to act as an anti-viral defense, the Picornaviridae avoid and, in many cases, subvert this pathway to promote their own replication. Evidence indicates...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

In tomato crop, the induction of resistance emerges as an important alternative for achieving the reduction of chemicals in disease control. This study aimed to evaluate the ability of 28 Trichoderma isolates to promote the growth of tomato seedlings and to induce systemic resistance (ISR) against Xanthomonas euvesicatoria and Alternaria solani, the causal agents of bacterial spot and early blight, respectively. Twelve isolates promoted the increase of plant dry matter mass (DMM) above 100%, showing the great potential of these strains. All isolates were able to colonize the root system of tomato plants. The plant growth-promoting isolates were further evaluated for potential elicitation of ISR. Treatment of the soil with all Trichoderma isolates provided protection in tomato plants from 2...

UK PubMed Central (United Kingdom)

The importance of cancer metabolism has been appreciated for many years, but the intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully understood. With a clear understanding...Full Text Available

Science.gov (United States)

... Ground, Maryland 21005 Brigadier General Edwin P. Smith Assistant Division Commander 82nd Airborne Division Fort Bragg, North Carolina ...

UK PubMed Central (United Kingdom)

BackgroundThe evaluation of interventions and policies designed to promote resilience, and research to understand the determinants and associations, require reliable and valid measures...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Ethnopharmacological relevance: Ethnobotanically driven drug-discovery programs include data related to many aspects of the preparation of botanical medicines, from initial plant collection to chemical extraction and fractionation. The Traditional Medicine Collection Tracking System (TM-CTS) was created to organize and store data of this type for an international collaborative project involving the systematic evaluation of commonly used Traditional Chinese Medicinal plants. Materials and methods: The system was developed using domain-driven design techniques, and is implemented using Java, Hibernate, PostgreSQL, Business Intelligence and Reporting Tools (BIRT), and Apache Tomcat. Results: The TM-CTS relational database schema contains over 70 data types, comprising over 500 data fields. Th...

CERN Document Server

We analyze the driven resonantly coupled Jaynes-Cummings model in terms of a quasienergy approach by switching to a frame rotating with the external modulation frequency and by using the dressed atom picture. A quasienergy surface in phase space emerges whose level spacing is governed by a rescaled effective Planck constant. Moreover, the well-known multiphoton transitions can be reinterpreted as resonant tunneling transitions from the local maximum of the quasienergy surface. Most importantly, the driving defines a quasienergy well which is nonperturbative in nature. The quantum mechanical quasienergy state localized at its bottom is squeezed. In the Purcell limited regime, the potential well is metastable and the effective local temperature close to its minimum is uniquely determined by the squeezing factor. The activation occurs in this case via dressed spin flip transitions rather than via quantum activation as in other driven nonlinear ...

Energy Technology Data Exchange (ETDEWEB)

It is shown that a gun similar to that in the SSPX could demonstrate the high fields required for Pulsed Spheromak reactors merely by prolonging the pulse. Important considerations are choosing the voltage to exceed ohmic losses; designing the gun to avoid wasteful short-circuiting of current within the gun; and the injection efficiency factor, f, determined by the ''sag'' in the profile of {lambda} = {mu}{sub o}j/B. Typically f = 0.75 in experiments, giving an overall efficiency > 50 % if short-circuiting is avoided. Theoretical transport models agree qualitatively with the need for a finite gradient in h to pump in helicity by current-driven tearing modes and suggest that pressure-driven resistive modes would not compete with current-driven modes during a buildup to ohmic ignition.

International Nuclear Information System (INIS)

Thermoacoustics deals with the conversion of heat energy into sound energy and vice versa. It is a new and emerging technology which has a strong potential towards the development of sustainable and renewable energy systems by utilizing waste heat or solar energy. Although simple to fabricate, the designing of thermoacoustic devices is very challenging. In the present study, a comprehensive design and optimization algorithm is developed for designing thermoacoustic devices. The unique feature of the present algorithm is its ability to design thermoacoustically-driven thermoacoustic refrigerators that can serve as sustainable refrigeration systems. In addition, new features based on the energy balance are also included to design individual thermoacoustic engines and acoustically-driven thermoacoustic refrigerators. As a case study, a thermoacoustically-driven thermoacoustic refrigerator has been designed and optimized based ...

UK PubMed Central (United Kingdom)

One of the requirements for a federated information system is interoperability, the ability of one computer system to access and use the resources of another system. This feature is particularly...Full Text Available

UK PubMed Central (United Kingdom)

SUMMARYThe biologic and clinical significance of KIT overexpression that associates with KIT gain-of- function mutations occurring in subsets...Full Text Available

UK PubMed Central (United Kingdom)

Electrospinning, a flexible jet-based fiber, scaffold, and membrane fabrication approach, has been elucidated as having significance to the heath sciences. Its capabilities have been most impressive...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

For supersonic plasma flow velocities, instead of the usual shelf-step profile seen for subsonic flow, an overdense bump and cavity is observed. The profile is stable for long times even for moderate power microwaves.

UK PubMed Central (United Kingdom)

Computational prediction of microRNA targets remains a challenging problem. The existing rule-based, data-driven and expression profiling approaches to target prediction are mostly approached from the...Full Text Available

UK PubMed Central (United Kingdom)

In Lepidoptera, forewings and hindwings are mechanically coupled and flap in synchrony. Flight is anteromotoric, being driven primarily by action of the forewings. Here we report that lepidopterans...Full Text Available

UK PubMed Central (United Kingdom)

We introduce in this paper a new method for reducing neurodynamical data to an effective diffusion equation, either experimentally or using simulations of biophysically detailed models. The dimensionality...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This report describes Northern Indiana Public Service Co. project efforts to develop an automated energy distribution and reliability system. The purpose of this project was to implement a database-driven GIS solution that would manage all of the company's gas, electric, and landbase objects.

ScienceCinema

...global warming problem became undeniable ...as global warming are a number also review they world energy ...global warming temperatures on the models and people take what's called ...? story combat global warming conservation ...

UK PubMed Central (United Kingdom)

Transcription for a hybrid SV40 promoter-beta globin coding sequence recombinant initiates from both early-early (EE) and late-early (LE) SV40 start sites (EES and LES) in the absence of DNA replication....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Current information suggests that chemical carcinogenesis is a multistep process with one of the best studied models in this regard being the two-stage carcinogenesis system using mouse skin. The effects of several carcinogens and tumor promoters in various sequences of application were studied to examine the nature of the process. The actions of several tumor inhibitors were compared. (ACR)

International Nuclear Information System (INIS)

The heat transfer augmentation is reviewed in view of high temperature heat exchangers illuminating the contribution of radiative heat transfer. A number of means and/or devices are presented as well as the sophisticated concept which will be promoted to the extended applications in matured industries such as iron and steel, oir refinery, petro-chemical. It should be emphasized that the more creative and innovatory technology has to be promoted in order to stimulate and refresh the foregoing industries, recognizing the increasing importance of the energy resources.

Energy Technology Data Exchange (ETDEWEB)

The centroid and envelope dynamics of a high-intensity charged particle beam are investigated as a beam smoothing technique to achieve uniform illumination over a suitably chosen region of the target for applications to ion-beam-driven high energy density physics and heavy ion fusion. The motion of the beam centroid projected onto the target follows a smooth pattern to achieve the desired illumination, for improved stability properties during the beam-target interaction. The centroid dynamics is controlled by an oscillating "wobbler", a set of electrically-biased plates driven by RF voltage. __________________________________________________

Energy Technology Data Exchange (ETDEWEB)

The authors report experimental results of heat transfer in the region of transition to turbulence. The augmentation was induced through deployment of periodically placed cylindrical eddy promoters in parallel plane channel flows. Eight different configurations were used. The presence of eddy promoters displaced the point of transition from Reynolds number values of 1500 for the plane channel to around 400 for the least stable case. The value of Nusselt number at the transition for eddy promoters cases was up to 2.5 times higher than the one for the plane channel at the transition. Furthermore, the lower the transition Reynolds number, the higher the Nusselt number at the transition. For the cases where the diameter of the promoters was small and/or the pitch large, the heat transfer results in the transition region were consistent with values obtained from the Reynolds analogy when the analogy was ...

British Library Electronic Table of Contents (United Kingdom)

Increasing evidence has been accumulated indicating the important role of epigenetic regulation in tumor genesis. Previously, we observed that the transfection of hepatitis C virus core (HCVc) protein led to malignant transformation in normal biliary cells, and that tumor suppressor gene RASSF1A was downregulated in many hilar cholangiocarcinoma patients by hypermethylation in the promoter region. In the present study, we found SET and MYND domain-containing protein 3 (SMYD3), a novel histone methyltransferase, was overexpressed in cholangiocarcinoma patients especially in those with HCV infection. Transfection of HCVc into hilar cholangiocarcinoma cell lines QBC939 and FRH0201 could upregulate the expression of SMYD3 and promote cell growth, which was consistent with the results of our cl...

Science.gov (United States)

The Plasma and Ion Source Technology Group at the Lawrence Berkeley National Laboratory have been developing rf-driven ion sources for the last two decades. These sources are being used to generate both positive and negative ion beams. Some of these sources are operating in particle accelerators such as the Spallation Neutron Source (SNS) at Oak Ridge, while others are being employed in various industrial ion beam systems. There are four areas where the rf-driven ion sources are commonly used in industry. (1) In semiconductor manufacturing, rf-driven sources have found important applications in plasma etching, ion beam implantation, and ion beam lithography. (2) In material analysis and surface modification, miniature rf-ion sources can be found in focused ion beam systems. They can provide ion beams of essentially any element in the Periodic Table. The newly developed combined rf ion-electron beam unit improves greatly the ...

Wastenet

CLIMATE CHANGE Copenhagen: seal the deal ...2 OUR PLANET SEAL THE DEAL UNEP promotes environmentally sound practices globally and in its own activities. ...PaGE 30OUR PLANET SEAL THE DEAL 3

UK PubMed Central (United Kingdom)

In the decade before the discovery of insulin, the prominent American physicians Frederick Allen and Elliott Joslin advocated severe fasting and undernutrition to prolong the lives of diabetic patients....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundProlylcarboxypeptidase (Prcp) gene, along with altered PRCP and kallikrein levels, have been implicated in inflammation pathogenesis. PRCP regulates angiotensin...Full Text Available

UK PubMed Central (United Kingdom)

Mitochondria and peroxisomes execute some analogous, nonredundant functions including fatty acid oxidation and detoxification of reactive oxygen species, and, in response to select metabolic cues, undergo...Full Text Available

UK PubMed Central (United Kingdom)

Hypoxia inducible factor-1 (HIF-1) promotes tumor cell adaptation to microenvironmental stress. HIF-1 is up-regulated in irradiated tumors and serves as a promising target for radiosensitization....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundIn Pseudomonas fluorescens ST, the promoter of the styrene catabolic operon, PstyA, is induced by styrene and is subject to catabolite...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundFree nitric oxide (NO) reacts with sulphydryl residues to form S-nitrosothiols, which act as NO reservoirs. We sought to determine whether thiol-preserving...Full Text Available

UK PubMed Central (United Kingdom)

As the Medical Library Association (MLA) enters its second century, its role in providing leadership and focus for the education of health information professionals in a changing environment will be...Full Text Available

UK PubMed Central (United Kingdom)

Recent clinical trials demonstrate that combined oral dosing with estrogen and progestin increases the incidence of breast cancer in post-menopausal women. Similarly, in a rat model system of...Full Text Available

UK PubMed Central (United Kingdom)

Background:Encouragement of stroke patients to resume driving is important to promote their reintegration into the community. Limited rehabilitation has been performed in this regard,...Full Text Available

Science.gov (United States)

To promote more efficient use of small-diameter timber, research efforts are being focused on the development and evaluation of connection methods that can be easily applied to non-standard round wood profiles. This report summarizes an evaluation of a 'd...

UK PubMed Central (United Kingdom)

The length polymorphism of the serotonin (5-HT) transporter gene promoter region has been implicated in altered 5-HT function and, in turn, neuropsychiatric illnesses, such as anxiety and depression....Full Text Available

UK PubMed Central (United Kingdom)

A DNA sequence encoding the A chain of ricin toxin (RTA) from the castor bean plant, Ricinus communis, was placed under GAL1 promoter control and transformed into Saccharomyces cerevisiae. Induction...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Subjects covered in this section are: (1) PCAST panel promotes energy research cooperation; (2) Letter issued by ANS urges funding balance in FFTF restart consideration and (3) FESAC panel releases report on priorities and balance.

UK PubMed Central (United Kingdom)

Most genetic changes that promote tumorigenesis involve dysregulation of G1 cell cycle progression. A key regulatory site in G1 is a growth factor–dependent restriction point (R) where cells...Full Text Available

UK PubMed Central (United Kingdom)

Continuing Medical Education (CME) is a requirement among practicing physicians to promote continuous enhancement of clinical knowledge to reflect new developments in medical care. Previous research...Full Text Available

UK PubMed Central (United Kingdom)

Minoxidil induces hair growth in male pattern baldness and prolongs the anagen phase. All-trans retinoic acid (ATRA) has been reported to act synergistically with minoxidil in vivo:...Full Text Available

UK PubMed Central (United Kingdom)

This program focused on practice-level service change as a means of improving patient care and developing leadership skills of 19 general practitioners (GPs) and aimed to: promote and support change...Full Text Available

UK PubMed Central (United Kingdom)

The Salmonella PmrA-PmrB system controls the expression of genes necessary for polymyxin B resistance. Four loci were previously identified as part of the regulon, and interaction of...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundDespite considerable efforts to promote and support guideline use, adherence is often suboptimal. Barriers to adherence vary not only across guidelines but also across...Full Text Available

UK PubMed Central (United Kingdom)

Several studies have raised the possibility that exposure to electrical and/or magnetic fields may be injurious to health in particular by the promotion or initiation of cancer. To investigate whether...Full Text Available

UK PubMed Central (United Kingdom)

The Far UpStream Element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, the FBP transcriptional activator binds to the FUSE DNA element upstream...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundAgricultural practices such as the use of irrigation during rice cultivation, the use of ponds for fish farming and the storage of water in tanks for livestock provide...Full Text Available

UK PubMed Central (United Kingdom)

Red cell transfusions are associated with the development of acute lung injury in the critically ill. Recent evidence suggests that storage induced alterations of the red blood cell (RBC) collectively...Full Text Available

UK PubMed Central (United Kingdom)

Decitabine, an epigenetic modifier that reactivates genes otherwise suppressed by DNA promoter methylation, is effective for some, but not all cancer patients, especially those with solid tumors. It...Full Text Available

UK PubMed Central (United Kingdom)

The definition of “minor” veins in leaves is arbitrary and of uncertain biological significance. Generally, the term refers to the smallest vein classes in the leaf, believed to function...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Taiwan has completed a very successful five-year industrial waste minimization (IWM) demonstration and promotion project sponsored by the government. From 1990 to 1995, the project successfully disseminated the IWM concept of pollution prevention (P2) to industries. It effectively reduced industrial waste while significantly benefitting the economy by assisting industries in implementing in-plant IWM programs. In July 1995, the second stage of the five-year IWM and ISO 14000 promotion project was initiated for further promoting the IWM, P2, and cleaner production and, in particular, coping with the upcoming international environmental management standards (ISO 14000). To assist industries in establishing an environmental management system (EMS) and accumulating related experience, an EMS pilot demonstration project of five model industries and an ISO 14001 EMS demonstration and promotion project for 22 ...

UK PubMed Central (United Kingdom)

Tetrabutylammonium fluoride will remove phenyl, trichloroethyl and cyanoethyl groups from nucleotides. In addition to the desired nucleotide products other results including chain cleavage, phosphofluoridates...Full Text Available

UK PubMed Central (United Kingdom)

Enrichment cultures were used to determine the conditions promoting fastest methanogenic propionate degradation and growth by adapting the cultures to various physical and chemical conditions and measuring...Full Text Available

UK PubMed Central (United Kingdom)

Cholera outbreaks continue to occur regularly in Africa. Cholera has been associated with proximity to lakes in East Africa, and Vibrio cholerae has been found experimentally to concentrate...Full Text Available

UK PubMed Central (United Kingdom)

Japanese medaka (Oryzias latipes) embryos exposed to ethanol have developed craniofacial, cardiovascular and skeletal defects which can be compared with the phenotypic features...Full Text Available

UK PubMed Central (United Kingdom)

Health education and awareness involves providing knowledge about causes of illness and choices to promote a change in individual behaviour and, thus, improves survival of individuals. Studies have,...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundLeukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of ...Full Text Available

International Nuclear Information System (INIS)

A series of lab and greenhouse studies were undertaken to understand how Cu and Zn toxicity influences Bromus carinatus (Hook and Arn.) growth, to what degree an organic amendment (yard waste compost) may reduce Cu and Zn bioavailability in Cu-Zn minespoil and promote plant growth in combination with fertilizer, and how the vertical distribution of compost in the minespoil influences rooting depth. Root Cu and Zn toxicity thresholds were determined to be 1 mg L"-"1 and 10 mg L"-"1 in solution, respectively. The compost amendment had exceptionally high Cu and Zn binding capacities (0.17 and 0.08 g metal g C"-"1, for Cu and Zn, respectively) that were attributed to high compost humic and fulvic acid concentrations. Maximum plant biomass was achieved when minespoil was amended with compost and fertilizer in combination. Fertilizer alone had no effect on plant growth. Mixing compost into the minespoil was essential to promote adequate rooting ...

UK PubMed Central (United Kingdom)

BackgroundInterest in lycopene metabolism and regulation is growing rapidly because accumulative studies have suggested an important role for lycopene in human health promotion....Full Text Available

UK PubMed Central (United Kingdom)

This article addresses the problem of how to ensure consistency in messages communicating public health recommendations on environmental health and on child health. The World Health Organization states...Full Text Available

UK PubMed Central (United Kingdom)

SummaryMonoclonal antibodies are standard therapeutics for several cancers including the anti-CD20 antibody rituximab for B cell non-Hodgkin lymphoma (NHL). Rituximab and other...Full Text Available

UK PubMed Central (United Kingdom)

Pharmacologic or genetic deletion of components of the renin-angiotensin system leads to postnatal kidney injury, but the roles of these components in kidney development are unknown. To test the hypothesis...Full Text Available

UK PubMed Central (United Kingdom)

Part one of this study investigated the effect of aging on social-cognitive characteristics related to physical activity (PA) among adults in the baseline phase of a health promotion...Full Text Available

UK PubMed Central (United Kingdom)

IntroductionMale circumcision is being promoted for HIV prevention in high-risk heterosexual populations. However, there is a concern that circumcision may impair...Full Text Available

UK PubMed Central (United Kingdom)

Siderophores are essential factors for iron (Fe) acquisition in bacteria during colonization and infection of eukaryotic hosts, which restrain iron access through iron-binding protein, such as lactoferrin...Full Text Available

UK PubMed Central (United Kingdom)

Background/AimTobacco use reduces the effect of non-surgical periodontal therapy. Host-modulation with low-dose doxycycline (LDD) might favour repair and promote...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Experiments with fresh PWR fuel assemblies were performed to assess the {sup 252}Cf-source-driven frequency analysis method for measuring the subcriticality of spent fuel. The measurements at the Babcox and Wilcox Critical Experiments Facility mocked up between 17x17 fuel pins (single assembly) and a full array of 4961 fuel pins (about 17 fuel assemblies) in borated water with a fixed B concentration. For the full array, the B content of the water was varied from 1511 at delayed criticality to 4303 ppM. Measurements were done for various source-detector-fuel pin configurations; they showed high sensitivity of frequency analysis parameters to B content and fissile mass. Parameters such as auto and cross power spectral densities can be calculated directly by a more general model of the Monte Carlo code (MCNP-DSP). Calculation-measurement comparisons are presented. This model permits the validation of neutron and gamma ray transport calculational methods with ...

Energy Technology Data Exchange (ETDEWEB)

This paper describes recent measurements of the subcritical neutron multiplication factor using the /sup 252/Cf source-driven neutron noise analysis method. This work was supported by a program of collaboration between the United States Department of Energy and the Power Reactor and Nuclear Fuel Development Corporation of Japan related to the development of fast breeder technology. The experiment reported consists of a configuration of two interacting tanks of uranyl nitrate aqueous solution with different uranium concentrations in each tank. The /sup 252/Cf-source-driven neutron noise analysis method obtains the subcriticality from the signals of three detectors: the first, a parallel plate ionization chamber with /sup 252/Cf electroplated on one of its plates that is located in or near the system containing the fissile material, and produces an electrical pulse for every spontaneous fission that occurs and thereby serves as a timed source of ...

International Nuclear Information System (INIS)

In partnership with the US Navy, high-technology corporations, and research universities, Jefferson Lab is building a superconducting radio-frequency (SRF) accelerator-driven free-electron laser (FEL) and is outfitting an FEL user facility. This first fourth-generation light source - a 1 kW, 3 #mu#m infrared (IR) laser - is the first step in a program to develop high-average-power SRF-based IR and ultraviolet (UV) FELs for multiple manufacturing applications as well as for defense-related applied research and basic scientific research. This initial FEL will be driven by a 42 MeV, 5 m A recirculating SRF linac similar to the much larger SRF linac in Jefferson Lab's 4 GeV, 200 #mu#A Continuous Electron Beam Accelerator Facility (CEBAF). The FEL is expected to demonstrate 75% energy recovery. Its linac will be cooled by the existing CEBAF cryogenic system. At Jefferson Lab, an infrastructure of facilities and people already supports the advance of ...

Science.gov (United States)

Vascular endothelial growth factor (VEGF) is a mitogen that is critically involved in vasculogenesis, angiogenesis, and hematopoiesis. However, what and how transcription factors participate in the regulation of vegf gene expression are not fully understood. Here we report the cloning and sequencing of the zebrafish vegf promoter which revealed that the promoter contains a number of bone morphogenetic protein (BMP)-activated Smad binding elements (SBE), implicating Smad1 and Smad5 in the regulation of BMP-induced expression of vegf. Electrophoretic mobility shift assays of adding recombinant Smad proteins to the SBE-containing DNA oligonucleotides that represent portions of zebrafish vegf promoter resulted in mobility shift of the oligonucleotides. These changes demonstrate potential interactions between Smad1/5 and the vegf promoter. Reporter activity assays using the wild-type or SBE-deleted vegf ...

CERN Document Server

Jet-driven shocks are responsible for an important fraction of the emission of the narrow-line regions (NLRs) in many classes of AGN. However, this cannot explain all observations. It is clear that the remaining sources are photoionised by the active nucleus. The 2-d hydrodynamic models from the RSAA group support an evolutionary scenario whereby the shock-excited NLRs are initially jet-driven but later, ionizing photons from the central engine replace shocks as the main excitation mechanism and shock induced star formation may also become important. In their photoionized phase, dusty and radiation-pressure dominated evolution produces a self-regulated NLR spectrum. This model aso explains the coronal emission lines and fast (3000 km s$^{-1}$) outflows seen in some Seyferts.

International Nuclear Information System (INIS)

Supernova explosions within wind-driven bubbles are studied with 2D hydrodynamical calculations. Two different density distributions for the ejecta are considered: (i) a smooth, unfragmented power-law stratification, and (ii) a fragmented distribution. As in 1D models, the presence of the shell of interstellar swept-up matter causes the rapid evolution of the remnant to the radiative phase. The main 2D effects, for both fragmented and unfragmented ejecta, include: (i) substantial chaotic deviations from a purely radial flow in the remnant interior, (ii) efficient turbulent mixing between the ejecta and the shocked wind, resulting in homogenization of the former wind cavity, and (iii) severe distortion of the wind-driven shell by cooling and Rayleigh-Taylor instabilities. (author).

Energy Technology Data Exchange (ETDEWEB)

Making use of a back-to-back type double fission chamber and a lead slowing-down spectrometer driven by a 46 MeV electron linear accelerator, the fission cross sections of Am-241, Am-242m and Am-243 have been measured relative to that of U-235 from 0.1 eV to 10 keV with the energy resolution of about 40 % full width at half maximum. Each of the measured result has been compared with (1) the evaluated nuclear data in ENDF/B-VI and JENDL-3.2, and (2) the existing experimental data, whose evaluated and measured data were broadened by the energy resolution function of the spectrometer.

British Library Electronic Table of Contents (United Kingdom)

Abstract A large number of massive stars are known to rotate rapidly, resulting in a significant distortion and variation in surface temperature from the pole to the equator. Radiatively driven mass-loss is temperature-dependent, so rapid rotation produces a variation in the mass-loss and angular momentum loss rates across the surface of the star, which is expected to affect the evolution of rapidly rotating massive stars. In this work, we use zero-age main-sequence (ZAMS) stellar models to investigate the two-dimensional effects of rotation on stellar mass-loss, using two common prescriptions for radiatively driven mass-loss. The associated loss of angular momentum from these models is also considered. Using 2D stellar models, which give the variation in surface parameters as a function o...

Energy Technology Data Exchange (ETDEWEB)

A design of a compact free-electron laser (FEL), generating ultra-fast, high-peak flux, XUV pulses is presented. The FEL is driven by ahigh-current, 0.5 GeV electron beam from the Lawrence Berkeley National Laboratory (LBNL) laser-plasma accelerator, whose active acceleration length is only a few centimeters. The proposed ultra-fast source (~;;10 fs) would be intrinsically temporally synchronized to the drive laser pulse, enabling pump-probe studies in ultra-fast science. Owing to the high current (>10 kA) of the laser-plasma-accelerated electron beams, saturated output fluxes are potentially greater than 10^13 photons/pulse. Devices based both on self-amplified spontaneous emission and high-harmonic generated input seeds, to reduce undulator length and fluctuations, are considered.

International Nuclear Information System (INIS)

TAPP-3 and 4 reactors use large number of Self Powered Neutron Detectors (SPNDs) for Neutronic lower measurement and control. To perform in-situ calibration of these detectors in select locations and to validate the reactor physics codes which predict flux at various points in the core, traveling in-core probes (TIP) are required. The TIP assembly consists of a miniature neutron sensitive detector. The detector is driven in and out of core using a mechanism which facilitates positioning of the detector anywhere inside a vertical tube (Central carrier tube of any of the six select Vertical Flux Units) in the core. TIP is driven through retractable feed mechanism for a stroke of 13 m. This paper describes the developmental efforts and the operational feedback of the retractable feed mechanism for the stroke of 13 m used at TAPP 3 and 4 reactor. (author)

Energy Technology Data Exchange (ETDEWEB)

In order to study nuclear criticality safety related to the development of fast breeder technology, /sup 252/Cf-source-driven neutron noise analysis measurements were performed with a Pu-U nitrate solution in a slab tank of various heights and thickness varying 11.43 cm to 19.05 cm. The results and conclusions of these experiments are (1) a capability to measure the subcriticality of a multiplying system of slab geometry to a k/sub eff/ as low as 0.7 was demonstrated, (2) calculated neutron multiplication factors agreed with those from the experiments within approx.0.02, and (3) the applicability of the method for plutonium solution systems was demonstrated. This paper describes measurements in which the height of the slab was varied for a fixed thickness and the thickness varied for a fixed height, which are the first applications of this measurement method to slab geometry.

Energy Technology Data Exchange (ETDEWEB)

This patent describes a turbocharger for a two-cycle engine having an oil mist containing crankcase and burning a mixture of liquid fuel containing lubricating oil therein wherein the turbocharger comprises a shaft mounted in a housing for rotation by an exhaust-driven turbine on one end to a drive compressor on the other end connected to supply pressurized air for the fuel/air mixture of the engine, the improvement to supply lubrication to the shaft and automatically enrichen the fuel/air mixture during high speed turbocharging.

Energy Technology Data Exchange (ETDEWEB)

This paper deals with the control of an electromechanical valves engine. The control uses neural networks in order to build a non-linear model of engine filing which depends on the driven inlets. The aim is to build this real-time model and to integrate this model to a control system which performs an iterative inversion. (J.S.)

Energy Technology Data Exchange (ETDEWEB)

Biological motors generally fall into two categories: (1) those that convert chemical into mechanical energy via hydrolysis of a nucleoside triphosphate, usually adenosine triphosphate, regarded as life's chemical currency of energy and (2) membrane bound motors driven directly by an ion gradient and/or membrane potential. Here we argue that electrostatic interactions play a vital role for both types of motors and, therefore, the tools of physics can greatly contribute to understanding biological motors.

Energy Technology Data Exchange (ETDEWEB)

The invention deals with a pumping plant for oil filled power cables. An air driven piston type pump is used as primary pump. A PLS (Programmable Logic control System) is used to control the oil flow to the cable(s). Improvements of the pump includes means for ensuring that the pump piston is operated also at low pressure and flow, and means for sealing off the piston rod to ensure maximum life of seals, to facilitate detection of possible leakages and to avoid contamination of the cable oil. 3 figs.

Energy Technology Data Exchange (ETDEWEB)

This paper will describe the application of power generation by the use of microturbine technology by Capstone Turbine Corporation throughout South America. The purpose of this paper is to describe the technology and the experience gained over the last six years. The microturbines are power generation systems that produce energy from a diverse range of liquid or gaseous fuels. The generator is driven by a small gas turbine with a common shaft for the rotors of the generator and the engine. (author)

UK PubMed Central (United Kingdom)

Mice lacking Kv1.1 Shaker-like potassium channels encoded by the Kcna1 gene exhibit severe seizures and die prematurely. The channel is widely expressed in...Full Text Available

CERN Document Server

We propose a scheme able to generate stationary continuous variable entanglement between an optical and a microwave cavity mode by means of their common interaction with a micro-mechanical resonator. We show that when both cavities are intensely driven one can generate bipartite entanglement between any pair of the tripartite system, and that, due to entanglement sharing, optical-microwave entanglement is efficiently generated at the expense of microwave-mechanical and opto-mechanical entanglement.

Energy Technology Data Exchange (ETDEWEB)

Some 200 visitors attended the official opening of a new diesel engine driven cogeneration plant in the city of Hamburg at the end of March. The dual fuel engine built by Blohm+Voss will supply 7.7 MW of electricity to the grid and 8.26 MW of thermal power to generate steam and hot water. (author)

Energy Technology Data Exchange (ETDEWEB)

At HMC, fundamental research on the hydrogen fueled engine and vehicle has been carried out. For this engine, solenoid driven injector is used to supply gaseous hydrogen into the cylinder and various operating parameters have been changed to study the combustion characteristics of hydrogen. After these experiments on the engine, a hydrogen fueled vehicle has been constructed and it is controlled by an ECU. The amount of emission from the hydrogen vehicle with stoichiometric operation is less than 1/3 of the ULEV legislation.

UK PubMed Central (United Kingdom)

In this study, the expression patterns of zif268 and arc were investigated in the basolateral amygdala (BLA) and dorsal hippocampal (dHPC) subregions during context-induced...Full Text Available

UK PubMed Central (United Kingdom)

HMGA2 is a DNA minor-groove binding protein. We previously demonstrated that HMGA2 binds to AT-rich DNA with very high binding affinity where the binding of HMGA2 to poly(dA-dT)₂ is enthalpy-driven...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Toroidicity Alfven Eigenmodes (TAE) in ITER can be driven unstable by two groups of energetic particles, the 3.5 MeV {alpha}-particle fusion products and the tangentially injected 1MeV beam ions. Stability conditions are established using the perturbative NOVA/NOVA-K codes. A quasi-linear diffusion model is then used to assess the induced redistribution of energetic particles.

CERN Document Server

Leveraging the potential power of even small handheld devices able to communicate wirelessly requires dedicated support. In particular, collaborative applications need sophisticated assistance in terms of querying and exchanging different kinds of data. Using a concrete example from the domain of mobile learning, the general need for information dissemination is motivated. Subsequently, and driven by infrastructural conditions, realization strategies of an appropriate middleware service are discussed.

DEFF Research Database (Denmark)

Now, more than ever, there are serious health concerns for obese and overweight children. Schools are the perfect setting for children to learn, and this influence can play an important role in preventing children from becoming obese and overweight. The study concerns the behaviors of Health Promoting School (HPS) according to a broad definition of HPS in World Health Organization (WHO), or dependent on schools own health promoting policies. The purpose of study research is to examine whether promoting physical activity among the children at schools in relation to a school health policy such as Food and Nutrition Policy (FNP). This was determined through the comparisons between the FNP based schools and non policy based schools. The study undertook surveys among school food coordinators in the selected Danish primary schools through a web-based questionnaire. The questions in the survey were more focused on physical ...

Energy Technology Data Exchange (ETDEWEB)

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the JC virus (JCV), a human papovavirus. PML is a relatively rare disease seen predominantly in immunocompromised individuals and is a frequent complication observed in AIDS patients. The significantly higher incidence of PML in AIDS patients than in other immunosuppressive disorders has suggested that the presence of human immunodeficiency virus type 1 (HIV-1) in the brain may directly or indirectly contribute to the pathogenesis of this disease. In the present study the authors have examined the expression of the JCV genome in both glial and non-glial cells in the presence of HIV-1 regulatory proteins. They find that the HIV-1-encoded trans-regulatory protein tat increases the basal activity of the JCV late promoter, JCV{sub L}, in glial cells. They conclude that the presence of the HIV-1-encoded tat protein may positively affect the JCV lytic cycle ...

International Nuclear Information System (INIS)

This study is a task of ''Comprehensive study'' in ''nuclear energy basic technology research'', which is promoted under cooperation of four research institutes. The Electrotechnical Laboratory conducted, in 1991 in the first period of colaboration, on successful oscillation at visible region (598 nm) as the first case in Japan, construction of small type accumulation ring NIJI-IV for FEL, successful oscillation of visible range from 595 to 488 nm by installing optical krystron with maximum frequency in the world, and successful emittance lowering of accumulation beam by wide improvement of the ring. In the optical resonator, studies on minute loss measuring technique and on recovery from mirror deterioration were promoted. In the second period started from fiscal year of 1994, studies on FEL oscillation technique in short wavelength and upgrading of FEL corresponding to a frontier area were started, to succeed an oscillation experiment at 350 ...

Science.gov (United States)

In this study, four API X80 pipeline steels were fabricated by varying Mo, Cr, and V additions, and their microstructures and crystallographic orientations were analyzed to investigate the effects of their alloying compositions on tensile properties and Charpy impact properties. Because additions of Mo and V promoted the formation of fine acicular ferrite (AF) and granular bainite (GB) while prohibiting the formation of coarse GB, they increased the strength and upper-shelf energy (USE) and decreased the energy transition temperature (ETT). The addition of Cr promoted the formation of coarse GB and hard secondary phases, thereby leading to an increased effective grain size, ETT, and strength, and a decreased USE. The addition of V resulted in a higher strength, a higher USE, a smaller effective grain size, and a lower ETT, because it promoted the formation of fine and homogeneous of AF and GB. The steel that contains 0.3 wt ...

British Library Electronic Table of Contents (United Kingdom)

Amyloid precursor protein (APP), a key protein in pathogenesis of Alzheimer's disease (AD), is a type I transmembrane protein which can be cleaved by b- and g-secretase to release the amyloidogenic b-amyloid peptides (Ab) and the APP intracellular domain (AICD). While Ab has been widely believed to initiate pathogenic cascades culminating AD, the physiological functions and regulations of AICD remain elusive. In present study, endogenous AICD was demonstrated to be increased by canonical Wnt signal. Instead of due to g-secretase activity, enhanced AICD expression was found due to the increased protein stability by Wnt/b-catenin. b-Catenin was demonstrated to be an associating partner of AICD, capable of promoting AICD mediated transcriptional activity. Investigation by AICD mutants proved ...

British Library Electronic Table of Contents (United Kingdom)

Schools have increasingly been targeted as appropriate sites for mental health promotion and teachers are considered well placed to identify issues concerning students' social and emotional well-being. Whilst teachers are now expected to be responsive to a wide range of student needs and circumstances, they receive little in their pre-service and subsequent teacher education to adequately prepare them for such realities. This paper reports the findings of a study that investigated teacher perspectives on student mental health and mental health education, including their sense of self-efficacy in relation to promoting and supporting children's mental well-being in schools. These findings highlight a complex interplay between teachers' constructions of 'mental health', the importance they pl...

Energy Technology Data Exchange (ETDEWEB)

Polyethylene (UHMWPE) wear in current knee prosthesis causes prosthesis loosening after no more than 15 years. In this work, a steady state one-dimensional lubrication model with non- Newtonian fluid, porous elastic layer on tibial component, ultra-filtration mechanism of fluid and some features of the surface roughness is studied through a numerical technique based on the Finite Element Method. The results show that the UHMWPE stiffness makes difficult the lubrication mechanism of the artificial joint and promotes abrasive and fatigue wear. Nevertheless, the use of compliant porous materials on the tibial component could reduce friction and wear. Moreover, the ultra-filtration mechanism promotes efficiency on the joint.

British Library Electronic Table of Contents (United Kingdom)

Abstract Policy-makers are increasingly recognising that the promotion of more sustainable consumption patterns is an indispensable prerequisite for achieving sustainable development in the long term. Policy documents and action plans have been published, and a wide array of policy instruments has been implemented with the aim of reducing the environmental and social burdens of consuming goods and services. But what are the latest trends and innovative approaches in sustainable consumption (SC) policies? What could be learnt for future policy-making? Based on an overview of European policy instruments and several case studies, the paper discusses instructive examples of SC policy instruments, in particular the Danish information campaign "One Tonne Less", the Dutch tax incentive scheme "Gr...

British Library Electronic Table of Contents (United Kingdom)

This article analyses the process of preparing the proposal for a new Finnish National Waste Plan (NWP 2007-2016). The focus of this study is on the use of the alternative concepts of waste prevention or material efficiency and on the shift in discourse from the former to the latter concept. The strengths and weaknesses of these competing concepts were analysed using criteria such as synergy, semantic aspects, legal context and applicability to monitoring. The discourse presented by different stakeholder groups was analysed. The implications of choosing either of the concepts were illustrated. The author concludes that waste prevention can be promoted just as well, or even better from the perspective of improving material efficiency. The concept must be complemented by policy instruments w...

British Library Electronic Table of Contents (United Kingdom)

It is uncertain if downregulation of ?-adrenoceptor signaling pathway is promoted by an enhanced adrenergic tone at an early stage of cardiac disease, or it develops secondary to detrimental local myocardial changes in advanced heart failure. We examined the integrity of ?-adrenoceptor signaling pathway upon chronic infusion of isoproterenol, a ?-adrenoceptor agonist, at a dose producing no structural left ventricular (LV) remodeling and systolic dysfunction. Subcutaneous isoproterenol infusion (400??g?kg?1?h?1 over 16?days) to guinea pigs using osmotic minipumps produced no change in cardiac weights, LV internal dimensions, myocyte cross-sectional area, extent of interstitial fibrosis, and basal contractile function. Isolated, perfused heart preparations from isoproterenol-treated guinea ...

British Library Electronic Table of Contents (United Kingdom)

Several challenges currently exist for rational design of functional tissue engineering constructs within the host, which include appropriate cellular integration, avoidance of bacterial infections, and low inflammatory stimulation. This work describes a novel class of biodegradable, amphiphilic polyanhydrides with many desirable protein-material and cell-material attributes capable of confronting these challenges. The biocompatible amphiphilic polymer films were shown to release laminin in a stable and controlled manner, promote neural cell adhesion and differentiation, and evade inflammatory responses of the immune system. Using high-throughput approaches, it was shown that polymer chemistry plays an integral role in controlling cell?film interactions, which suggests that these polyanhyd...

CERN Document Server

The collapse of a massive star's core, followed by a neutrino-driven, asymmetric supernova explosion, can naturally lead to pulsar recoils and neutron star kicks. Here, we present a two-dimensional, radiation-hydrodynamic simulation in which core collapse leads to significant acceleration of a fully-formed, nascent neutron star (NS) via an induced, neutrino-driven explosion. During the explosion, a ~10% anisotropy in the low-mass, high-velocity ejecta lead to recoil of the high-mass neutron star. At the end of our simulation, the NS has achieved a velocity of ~150 km s$^{-1}$ and is accelerating at ~350 km s$^{-2}$, but has yet to reach the ballistic regime. The recoil is due almost entirely to hydrodynamical processes, with anisotropic neutrino emission contributing less than 2% to the overall kick magnitude. Since the observed distribution of neutron star kick velocities peaks at ~300-400 km s$^{-1}$, recoil due to anisotropic core-collapse ...

Science.gov (United States)

We investigate the features of the spontaneous emission spectra in a coherently driven cold five-level atomic system by means of a radio frequency (rf) or microwave field driving a hyperfine transition within the ground state. It is shown that a few interesting phenomena such as spectral-line narrowing, spectral-line enhancement, spectral-line suppression, and spontaneous emission quenching can be realized by modulating the frequency and intensity of the rf-driving field in our system. In the dressed-state picture of the coupling and rf-driving fields, we find that this coherently driven atomic system has three close-lying levels so that multiple spontaneously generated coherence (SGC) arises. Our considered atomic model can be found in real atoms, such as rubidium or sodium, so a corresponding experiment can be done to observe the expected phenomena related to SGC reported by Fountoulakis et al. [Phys. Rev. A 73, 033811 (2006)], since no ...

Energy Technology Data Exchange (ETDEWEB)

The dynamics of many natural and technical systems are essentially influenced by a periodic forcing. Analytic solutions of the equations of motion for periodically driven systems are generally not known. Simulations, numerical solutions or in some limiting cases approximate analytic solutions represent the known approaches to study the dynamics of such systems. Besides the regime of weak periodic forces where linear response theory works, the limit of a slow driving force can often be treated analytically using an adiabatic approximation. For this approximation to hold all intrinsic processes must be fast on the time-scale of a period of the external driving force. We developed a perturbation theory for periodically driven Markovian systems that covers the adiabatic regime but also works if the system has a single slow mode that may even be slower than the driving force. We call it the semi adiabatic approximation. Some results of this ...

International Nuclear Information System (INIS)

There has been a growing interest in new laser systems for use at mid-infra-red wavelengths, driven by requirements for a number of diverse applications. Developments in mid-IR coating technology are following three major thrusts. In the first, the potential of ion-assisted process is being exploited and the technology is already becoming well established in the optical coating industry. In the second, the benefits of using gas-phase precursors are being explored, driven by the potential of avoiding the generation of second phase inclusion in the coatings with associated reduction in laser damage threshold. Research is also addressing the use of nanocomposite materials with an engineered microstructure to produce coatings with dielectric properties of choice. This paper presents a review of progress in some of these areas with special emphasis on the comparison of the properties of materials at DF laser wavelengths. Evidence is presented which ...

Energy Technology Data Exchange (ETDEWEB)

The {sup 252}Cf-source-driven noise analysis method is a versatile measurements tool that has been applied to measurements for initial loading of reactors, quality assurance of reactor fuel elements, fuel processing facilities, fuel reprocessing facilities, fuel storage facilities, zero-power testing of reactors, verification of calculational methods, process monitoring, characterization of storage vaults, and nuclear weapons identification. This method`s broad range of application is due to the wide variety of time- and frequency domain signatures, each with unique properties, obtained from the measurement. The following parameters are obtained from this measurement: average detector count rates, detector multiplicities, detector autocorrelations, cross-correlation between detectors, detector autopower spectral densities, cross-power spectral densities between detectors, coherences, and ratios of spectral densities. All of these measured parameters can also be ...

Energy Technology Data Exchange (ETDEWEB)

During the past decades polymer membrane technology has been applied in various industries for a myriad of separation duties. They are also an important candidate for the solution of separation problems associated with the recovery of carbon dioxide in power plants. The application of membrane technology for carbon dioxide removal is discussed for two different ways of operation in present and future power plants. First, pressure driven operations are discussed, followed by a discussion of the use of membranes in absorbers. The pressure driven processes based on currently available gas separation membranes are shown to have poor separation characteristics. Further membrane development work appears to be necessary, especially in the area of temperature resistant membranes. Membrane selectivity goals are presented for present and future power plants. Membrane absorbers making use of commercially available absorption liquids and membranes possess ...

CERN Document Server

The term ``dynamo'' means different things to the laboratory fusion plasma and astrophysical plasma communities. To alleviate the resulting confusion and to facilitate interdisciplinary progress, we pinpoint conceptual differences and similarities between laboratory plasma dynamos and astrophysical dynamos. We can divide dynamos into three types: 1. magnetically dominated helical dynamos which sustain a large scale magnetic field against resistive decay and drive the magnetic geometry toward the lowest energy state, 2. flow-driven helical dynamos which amplify or sustain large scale magnetic fields in an otherwise turbulent flow, and 3. flow-driven nonhelical dynamos which amplify fields on scales at or below the driving turbulence. We discuss how all three types occur in astrophysics whereas plasma confinement device dynamos are of the first type. Type 3 dynamos requires no magnetic or kinetic helicity of any kind. Focusing on type 1 and 2 ...

Energy Technology Data Exchange (ETDEWEB)

This research focuses on the development and application of high order statistical analyses applied to measurements performed with subcritical fissile systems driven by an introduced neutron source. The signatures presented are derived from counting statistics of the introduced source and radiation detectors that observe the response of the fissile system. It is demonstrated that successively higher order counting statistics possess progressively higher sensitivity to reactivity. Consequently, these signatures are more sensitive to changes in the composition, fissile mass, and configuration of the fissile assembly. Furthermore, it is shown that these techniques are capable of distinguishing the response of the fissile system to the introduced source from its response to any internal or inherent sources. This ability combined with the enhanced sensitivity of higher order signatures indicates that these techniques will be of significant utility in a variety of ...

International Nuclear Information System (INIS)

The tremendous heat generated in a computer chip or very large scale integrated circuit raises many challenging issues to be solved. Recently, liquid metal with a low melting point was established as the most conductive coolant for efficiently cooling the computer chip. Here, by making full use of the double merits of the liquid metal, i.e. superior heat transfer performance and electromagnetically drivable ability, we demonstrate for the first time the liquid-cooling concept for the thermal management of a computer chip using waste heat to power the thermoelectric generator (TEG) and thus the flow of the liquid metal. Such a device consumes no external net energy, which warrants it a self-supporting and completely silent liquid-cooling module. Experiments on devices driven by one or two stage TEGs indicate that a dramatic temperature drop on the simulating chip has been realized without the aid of any fans. The higher the heat load, the larger will be the ...

Energy Technology Data Exchange (ETDEWEB)

The feasibility study on conceptual design methodology for accelerator-driven sodium-cooled sub-critical transmutation reactors has been conducted to optimize the design parameters from the scale laws and validates the reactor performance with the integrated code system. A 1000 MWth sodium-cooled sub-critical transmutation reactor has been scaled and verified through the methodology in this paper, which is referred to Advanced Liquid Metal Reactor (ALMR). A Pb-Bi target material and a partitioned fuel are the liquid phases, and they are cooled by the circulation of secondary Pb-Bi coolant and by primary sodium coolant, respectively. Overall key design parameters are generated from the scale laws and they are improved and validated by the integrated code system. Integrated Code System (ICS) consists of LAHET, HMCNP, ORIGEN2, and COMMIX codes and some files. Through ICS the target region, the core region, and thermal-hydraulic related regions are analyzed ...

Energy Technology Data Exchange (ETDEWEB)

Air flow and the buoyancy-driven flow through a building`s horizontal openings was discussed. Horizontal openings occur in staircases, stairwells, ventilation shafts and chimneys. Mass and energy transfer through them have important implications regarding energy saving, thermal comfort, control of contaminants and micro-organisms and spread of fire and smoke. The analysis of the buoyancy-driven flow was attained using computational fluid dynamics (CFD). Use was made of the CFD code FLUENT which integrated the Navier-Stokes equations by a time-dependent, finite volume method. Good agreement was achieved between predicted and experimental measurements of flow rate. Results showed that flow patterns in horizontal openings were transient and unstable. The air exchange through the openings occurred in intermittent pulses. The flow rate through the opening increased with the temperature difference between zones in buildings and the size of the ...

Energy Technology Data Exchange (ETDEWEB)

The /sup 252/Cf-source-driven neutron noise analysis method has been tested in a wide variety of experiments that have indicated the broad range of applicability of the method. The neutron multiplication factor k/sub eff/ has been satisfactorily detemined for a variety of materials including uranium metal, light water reactor fuel pins, fissile solutions, fuel plates in water, and interacting cylinders. For a uranyl nitrate solution tank which is typical of a fuel processing or reprocessing plant, the k/sub eff/ values were satisfactorily determined for values between 0.92 and 0.5 using a simple point kinetics interpretation of the experimental data. The short measurement times, in several cases as low as 1 min, have shown that the development of this method can lead to a practical subcriticality monitor for many in-plant applications. The further development of the method will require experiments oriented toward particular applications including dynamic ...

International Nuclear Information System (INIS)

The method of treatment of uteral cancer by the brake irradiation of 25 MeV betatrone using original devices which promote forming therapeutic figured bunches is presented. The binding of the protective blocks with a special adjusting frame within the aperture of the diaphragm provided for low relative entering dose which is the advantage of high energy irradiation bunch. The use of the forming devices makes it possible to practice individual treatment and decrease the levels of irradiation doses for intact organs and tissues.

UK PubMed Central (United Kingdom)

In both type 1 and type 2 diabetes, pancreatic islet dysfunction results in part from cytokine-mediated inflammation. The ubiquitous eukaryotic translation initiation factor 5A (eIF5A), which is the...Full Text Available

International Nuclear Information System (INIS)

The petroleum and petroleum products increase offer a real development opportunity to the alternative fuels. In the context of the french energy accounting increase, the energy independence notion incites the government to promote these new fuels. If the LPG seems declining because of the accident risks fear, the fuel cell is not for today. Near these two sectors what is the future of the biofuels and the natural gas vehicle or the electric cars? (A.L.B.)

Energy Technology Data Exchange (ETDEWEB)

A multiple metal oxide sorbent supported on a zeolite of substantially silicon oxide is used for the desulfurization of process gas streams, such as from a coal gasifier, at temperatures in the range of about 1200.degree. to about 1600.degree. F. The sorbent is provided by a mixture of copper oxide and manganese oxide and preferably such a mixture with molybdenum oxide. The manganese oxide and the molybdenum are believed to function as promoters for the reaction of hydrogen sulfide with copper oxide. Also, the manganese oxide inhibits the volatilization of the molybdenum oxide at the higher temperatures.

Wastenet

...Korea 2008 NOx charges as feebate in Sweden Pilot Project on Solid Waste Management in Khulna City: Community Organisation and Management Plastic Bag ban in Dhaka City, Bangladesh Policies on Conservation of the DMZ District Ecosystem Ministry of Environment Republic of Korea 2007 Policies on Promoting Environmental Industries and International Cooperation ...

UK PubMed Central (United Kingdom)

The Wnt signaling pathway is a robust regulator of skeletal homeostasis. Gain-of-function mutations promote high bone mass, whereas loss of Lrp5 or Lrp6 co-receptors decrease bone mass. Similarly, mutations...Full Text Available

CERN Document Server

This comprehensive guide offers several tried and true steps to help you successfully manage the complex process of developing free software. Topics include project management, developer motivation, technical infrastructure to support collaboration, and project promotion. Producing Open Source Software is ideal for developers starting their own free software projects, or people who simply want to participate in the process.

UK PubMed Central (United Kingdom)

The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical aspects of cell motility including FA disassembly and protrusion of the...Full Text Available

Wastenet

... Complete Wasters An exciting range of recycled, re-used, fairtrade and sustainable gifts as well as low cost recycled computer systems. Visit our mini eco centre, gift shop and wildlife garden. Since 1997 Complete Wasters has... recycled 700 tonnes of paper, card, cans, and bottles; refurbished 2000 PCs; planted 600 trees and promoted recycling to over 700,000 people at over ...

UK PubMed Central (United Kingdom)

BackgroundIn an effort to promote healthy ageing and preserve health and function, the government of Chile has formulated a package of actions into the Programme for Complementary...Full Text Available

UK PubMed Central (United Kingdom)

The leukocyte-enriched p110γ and p110δ isoforms of PI3K have been shown to control in vitro degranulation of mast cells induced by cross-linking...Full Text Available

UK PubMed Central (United Kingdom)

LRP1 is a type-1 transmembrane receptor that mediates the endocytosis of diverse ligands. LRP1 β-chain proteolysis results in release of sLRP1 that is present in human plasma. In this study,...Full Text Available

UK PubMed Central (United Kingdom)

We have developed a new expression vector, pcI^ts ind⁺, based upon the powerful rightward promoter of bacteriophage lambda, which is controlled by a temperature-sensitive...Full Text Available

Science.gov (United States)

Receptor interacting protein 140 (RIP140) is a coregulator for numerous nuclear receptors and transcription factors and primarily exerts gene-repressive activities on various target genes. We previously identified a spectrum of posttranslational modifications on RIP140 that augment its property and biological activity. In T(3)-triggered biphasic regulation of cellular retinoic acid binding protein 1 (Crabp1) gene along the course of fibroblast-adipocyte differentiation, we found TRAP220(MED1) critical for T(3)-activated chromatin remodeling whereas RIP140 essential for T(3)-repressive chromatin remodeling of this gene promoter. In this current study, we aim to examine whether and how RIP140 replaces TRAP220(MED1) on the CrabpI promoter in differentiating adipocyte cultures. We find increasing recruitment of RIP140 to this promoter, with corresponding reduction in TRAP220(MED1) recruitment during the T(3)-repressive phase. ...

International Nuclear Information System (INIS)

In the case of a release of residual power and fragmenting following a hypothetical accident the applied powers are small. The boiling in the fluid in the bed promotes leveling and the angles of repose obtained are very small. For a specific power in water of 3.1 W/cm_3 a limiting angle of repose of less than 2 degrees is obtained after a time interval of between 1 and 3 hours. EDULCOREE-and ETABUL-research programs are carried out. (DG).

Science.gov (United States)

A method of simultaneously removing SO.sub.2 and NO from oxygen-containing flue gases resulting from the combustion of carbonaceous material by contacting the flue gas with an aqueous scrubber solution containing an aqueous sulfur dioxide sorbent and an active metal chelating agent which promotes a reaction between dissolved SO.sub.2 and dissolved NO to form hydroxylamine N-sulfonates. The hydroxylamine sulfonates are then separated from the scrubber solution which is recycled.

UK PubMed Central (United Kingdom)

AIM: To evaluate the biological and clinical characteristics of miR-622 in gastric cancer.METHODS: We analyzed the expression of miR-622 in 57 pair matched gastric neoplastic and adjacent non-neoplastic...Full Text Available

UK PubMed Central (United Kingdom)

Cordycepin has been shown to interfere with a myriad of molecular processes from RNA elongation to kinase activity, and prevents numerous inflammatory processes in animal models. Here we show in a mouse...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The US Department of Energy, Office of Technical and Financial Assistance (OTFA) promotes the application of renewable energy and energy efficiency technologies and practices by working cooperatively with state and local governments and private and nonprofit organizations, providing technical and financial assistance and serving as network for sharing information. This report is an overview of some of the programs designed to aid in solving our national energy problems.

International Nuclear Information System (INIS)

The involvement and relationship of carbon steel corrosion products in the tube denting phenomenon promoted an intensive research effort to: 1) understand, reproduce, and arrest the denting process, and 2) evaluate alternative tube support materials to provide additional corrosion resistance. The paper summarizes a corrosion testing program for the verification of type 405 stainless steel under acid or all volatile treatment conditions.

Energy Technology Data Exchange (ETDEWEB)

Many commercial processes for the removal of carbon dioxide from high-pressure gases use aqueous potassium carbonate systems promoted by secondary amines. This paper presents thermodynamic and kinetic data for aqueous potassium carbonate promoted by piperazine. Research has been performed at typical absorber conditions for the removal of CO{sub 2} from flue gas. Piperazine, used as an additive in 20-30 wt% potassium carbonate, was investigated in a wetted-wall column using a concentration of 0.6 m at 40-80{sup o}C. The addition of 0.6 m piperazine to a 20 wt% potassium carbonate system decreases the CO{sub 2} equilibrium partial pressure by approximately 85% at intermediate CO{sub 2} loading. The distribution of piperazine species in the solution was determined by proton NMR. Using the speciation data and relevant equilibrium constants, a model was developed to predict system speciation and equilibrium. The addition of 0.6 m piperazine to 20 ...

UK PubMed Central (United Kingdom)

Cadmium (Cd) exposure causes glucosuria (glucose in the urine). Previously, it was shown that Cd exposure of primary cultures of mouse kidney cells (PMKC) decreased mRNA levels of the glucose...Full Text Available

UK PubMed Central (United Kingdom)

A chimeric recombinant, containing the 270 bp left-terminal fragment of Adenovirus-2 (Ad2) inserted upstream from the -34 to +33 Ad2 major late promoter (Ad2MLP) element, has been used to characterize...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This patent describes an automatic loading roller for transmitting torque in traction drive devices in manipulator arm joints includes a two-part camming device having a first cam portion rotatable in place on a shaft by an input torque and a second cam portion coaxially rotatable and translatable having a rotating drive surface thereon for engaging the driven surface of an output roller with a resultant force proportional to the torque transmitted. Complementary helical grooves on the respective cam portions interconnected through ball bearings interacting with those grooves effect the rotation and translation of the second cam portion in response to rotation of the first.

CERN Document Server

The energy fed by active galactic nuclei to the surrounding diffuse baryons changes the latter's amount, temperature, and distribution; so in groups and in member galaxies it affects the X-ray luminosity and also the Sunyaev-Zel'dovich effect. Here we compute how the latter is enhanced by the transient blastwave driven by a shining quasar, and is depressed when the equilibrium is recovered with a depleted density. We constrain such depressions and enhancements with the masses of relic black holes in galaxies and the X-ray luminosities in groups. We discuss how all these linked observables can tell the quasar contribution to the thermal history of the baryons pervading galaxies and groups.

Energy Technology Data Exchange (ETDEWEB)

Using the past diffusion trends of four renewable energy technologies for irrigation water pumping in India (SPV pumps, windmill pumps and biogas/producer gas driven dual fuel engine pumps), results of an attempt to project their future dissemination levels, have been presented in this study. The likely contribution of the renewable energy options considered in the study to the projected energy demand for irrigation water pumping in India has been estimated. Estimates of the associated investment requirements taking into account the learning effect have also been presented. (author)

Science.gov (United States)

Convective losses arising from buoyancy driven flow were calculated for a two-dimensional model simulating a solar cavity receiver. The TEMPEST code, capable of fully three-dimensional coupled thermal-hydraulic transient calculations, was used for the simulation. Predicted velocity and temperature results for a 2.59 m deep by 2.88 m high rectangular cavity with an aperture opening of 1.72 m were used to determine convective losses for prescribed interior wall temperatures and cavity orientation. Velocity vector and temperature isotherm plots were used to analyze flow characteristics.

Energy Technology Data Exchange (ETDEWEB)

ABB has developed an electric drive system featuring a high-energy, sodium-sulphur battery. The energy-to-weight ratio of this battery is four times that achieved with conventional lead-acid batteries. To recharge the battery, a charger mounted next to the motor has only to be connected to a household power socket. Road testing of electric cars is already under way, with production of commercially significant series planned for the early 1990s. The drive system will enable a typical family saloon to be driven at 120 km/h and allow a range of action of 200 km in urban traffic. (authors).

Energy Technology Data Exchange (ETDEWEB)

In response to the need of the Strategic Defence Initiative (SDI) and long range space exploration and extra-terrestrial basing by the National Air and Space Administration (NASA), concepts for nuclear power systems in the multi-megawatt levels are being evaluated. The requirements for these power systems are being driven primarily by the need to minimize weight and maximize safety and reliability. This paper discusses the present requirements for space based advanced power systems, technological issues associated with the development of these advanced nuclear power systems, and some of the concepts proposed for generating large amounts of power in space. (author).

Energy Technology Data Exchange (ETDEWEB)

Liberalisation of the power sector is on the increase on a global scale. Corporate-driven reforms are portrayed by international financial institutions and multilateral development banks as means of improving efficiency and attracting foreign investment for national economic growth. Most countries across the world are taking steps towards liberalisation, often to meet the conditions imposed by international donors or comply with regional or global trade agreements. This first issue of Power and Society attempts to look beyond the promised benefits of this trend and debunk some myths about privatisation and deregulation of the electricity sector.

Energy Technology Data Exchange (ETDEWEB)

An LPP ignition timing control is described for an internal combustion engine including a combustion chamber, means effective to ignite a combustible charge within the combustion chamber and power output apparatus including a rotating crankshaft driven in response to the expansion of the combustible charge following the ignition thereof and having a predefined TDC rotational reference position, the engine being of the type having a normal combustion mode characterized by combustion pressure peaks compatible with closed loop LPP ignition timing control and an abnormal combustion mode which may not be so compatible.

International Nuclear Information System (INIS)

We theoretically investigate the features of two-photon absorption in a coherently driven four-level atomic system with closed-loop configuration. It is found that two-photon absorption can be completely suppressed just by properly adjusting the relative phase of four coherent low-intensity driving fields and the atomic system becomes transparent against two-photon absorption. From a physical point of view, we explicitly explain these results in terms of quantum interference induced by two different two-photon excitation channels.

International Nuclear Information System (INIS)

Coherent x-ray production by a seeded free electron laser (FEL) is important for next generation synchrotron light sources. The authors examine the feasibility and features of FEL emission seeded by a high-order harmonic generation (HHG) of an infrared laser. In addition to the intrinsic FEL chirp, the longitudinal profile and spectral bandwidth of the HHG seed are modified significantly by the FEL interaction well before saturation. This smears out the original attosecond pulselet structure. The authors introduce criteria for this smearing effect on the pulselet and the stretching effect on the entire pulse. They discuss the noise issue in such a seeded FEL.

Energy Technology Data Exchange (ETDEWEB)

The effect of the electric field on an exciton confined in a pair of vertically coupled quantum dots is studied. We use a single-band approximation and a parabolic model potential. As a result of these idealizations, we obtain a numerically solvable model, which is used to describe the influence of the electron-hole interaction on the Stark effect for the lowest-energy photoluminescence lines. We show that for intermediate tunnel coupling between the dots this interaction leads to an anomalous Stark effect with an essential deviation of the recombination energy from the usual quadratic dependence on the electric field.

Energy Technology Data Exchange (ETDEWEB)

Closed string tachyons have long been somewhat mysterious. We note that there is often a regime in the classical moduli space in which one can systematically compute the effective action for such fields. In this regime, the tachyon is light, and cannot be integrated out. Instead, one must consider the combined dynamics of gravitons, moduli, tachyons and other light fields. We compute the action and find that the quartic term for the tachyon is positive in the field definition where the tachyon has no derivative coupling to the radion. We study the evolution of isotropic, homogeneous configurations and find that typically the system is driven to regions where the calculation is no longer under control. (author)

Energy Technology Data Exchange (ETDEWEB)

A back-up system is provided for a pumping plant or a pressure reservoir system used to maintain insulating oil under pressure in high voltage submarine power cables which includes a gas driven membrane pump to insure a small outflow of oil at a rupture point in the power cable to prevent water from penetrating the cable. The proper operation of the membrane pump is insured by introducing degasified oil at the drive side of the pump during the stand-by and test modes of operation of the back-up system. 11 drawings.

Energy Technology Data Exchange (ETDEWEB)

The approach-to-critical measurements reported were for a plate-type fuel element where the height of the water moderator and side and top reflector were increased. Measurements were also performed with each of the two annuli of the fuel element to verify both the presence of boron in the fuel plates and the proper uranium loading prior to assembly of the two annuli for full submersion measurements. Measurements were also performed with detectors external to the reflector (> 15 cm of water on top, bottom, and side) for the assembled, submerged HFIR fuel element.

Energy Technology Data Exchange (ETDEWEB)

Desiccant cooling is a potentially environmentally friendly technology that can be used to condition the internal environment of buildings. Unlike conventional air conditioning systems, which rely on electrical energy to drive the cooling cycle, desiccant cooling is a heat-driven cycle. This paper follows on from an initial study by the authors, and uses real meteorological data to evaluate the potential in the United Kingdom of using solar energy to drive the desiccant cooling cycle. Through the use of parametric studies, the paper investigates the energy consumption and costs associated with desiccant cooling. (author)

Energy Technology Data Exchange (ETDEWEB)

By contrast to the large mass, complexity and recirculating power of conventional drivers for inertial confinement fusion (ICF), antiproton annihilation offers a specific energy of 90MJ/{micro}g and thus a unique form of energy packaging and delivery. In principle, antiproton drivers could provide a profound reduction in system mass for advanced space propulsion by ICF. We examine the physics underlying the use of antiprotons ({bar p}) to drive various classes of high-yield ICF targets by the methods of volumetric ignition, hotspot ignition and fast ignition. The useable fraction of annihilation deposition energy is determined for both {bar p}-driven ablative compression and {bar p}-driven fast ignition, in association with 0-D and 1-D target burn models. Thereby, we deduce scaling laws for the number of injected antiprotons required per capsule, together with timing and focal spot requirements. The kinetic energy of the injected antiproton ...

Energy Technology Data Exchange (ETDEWEB)

Previous experiments in fast critical assemblies demonstrated a method of determining reactivity from power spectral density measurements with /sup 252/Cf. This method determines reactivity from properties of the reactor only at the subcritical state of interest, thus it does not require a calibration near delayed criticality. The interpretation of the measured data to obtain reactivity does not require knowledge of the relative or absolute values of the source intensity, knowledge of the detection efficiencies, or knowledge of the detection instrumentation frequency responses. An experiment was performed at the Pool Critical Assembly to evaluate the possibility of /sup 252/Cf source driven neutron noise spectral density measurements in light water moderated reactors. This experiment showed that using commercially available detectors, such measurements can be performed in a reasonable time, that is, the measurement of the quantity of interest (the ratio of spectral ...

Wastenet

...Events Archive Worldwide Africa Programme Arab Programme Asia and Pacific Programme Europe and NIS Programme Latin American and Caribbean Programme Least-Developed Countries South-South Cooperation Human Security Directory of Offices Research & Statistics Publications Research and Statistics Subsites Annual Report Evaluation Group Investment and Technology Promotion Policymaking Organs Legal Resources Goodwill Ambassadors Industrial Competitiveness and Trade Private Sector Development Environmental Management Energy and Climate Change Research and Statistics Financial Institutions Partnerships Thematic ...Events Archive Worldwide Africa Programme Arab Programme Asia and Pacific Programme Europe and NIS Programme Latin American and Caribbean Programme Least-Developed Countries South-South Cooperation Human Security Directory of Offices Research & Statistics Publications Research and Statistics Subsites Annual Report Evaluation Group Investment and ...

Science.gov (United States)

The Pawtucket Heart Health Program is one of the community studies examining whether population-based efforts to lower cardiovascular risk factors will reduce cardiovascular morbidity and mortality. The Pawtucket Heart Health Program intervention is based on a blend of social learning theory, community organization models, community psychology tenets, and diffusion research. This model allows for multifaceted programs that target individuals, groups, organizations, and the entire community to alter their cardiovascular risk through managing blood pressure, lowering blood cholesterol, quitting smoking, increasing fitness, and maintaining desirable weight levels. A dominant feature of the intervention is the emphasis that it places on volunteers for program delivery. The role of volunteers in providing direct services to help citizens lower their blood pressure and lose weight is highlighted to demonstrate the feasibility and effectiveness of these services. In addition, church-based ...

Science.gov (United States)

The effects of high-intensity pulsed electromagnetic stimulation (HIPEMS) on proliferation and differentiation of neonatal rat neural stem cells in vitro were investigated. Neural stem cells derived from neonatal rats were exposed to 0.1 Hz, 0.5-10 Tesla (T) [8 groups of B-I, respectively], 5 stimuli of HIPEMF. The sham exposure controls were correspondingly established. Inverted phase contrast microscope was used to observe the cultured cells, MTT assay to detect the viability of the cells as expressed by absorbance (A) value, and flow cytometry to measure differentiation of neural stem cells. The results showed that A values of neural stem cells in both 3.0 T and 4.0 T groups were significantly higher than the other groups 24 to 168 h post HPEMS, indicating a strong promotion of the growth of neural stem cells (PHPEMS groups was the same as that in control group (P>0.05). It was suggested that 0.1 Hz, 5 pulses stimulation of HPEMS within certain scale of ...

Energy Technology Data Exchange (ETDEWEB)

Hydrogenation of carbon monoxide at 101.3 kPa has been studied over a series of ion-exchanged Ru catalysts supported on NaX, NaY, KL, Na mordenite, and HY zeolites. The type of zeolite had pronounced effects on the activity and selectivity of the Ru. The specific activity would appear to be related to the dispersion of reduced ruthenium in the zeolite. Methane selectivity, however, seems to be strongly influenced by the type and concentration of alkali cations remaining in the ion-exchanged zeolite. These cations appear to promote chain growth much as traditional alkali promoters would, though perhaps more indirectly. Due to bifunctional properties of the zeolite-supported catalysts, a significant fraction of C/sub 4/ was in the form of isobutane. Formation of isobutane seems to be related to either the Si/Al ratio in the zeolites or the concentration of the remaining alkali cations, but not to the OH concentration. In addition, H/sub 2/ ...