WorldWideScience
1

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase  

UK PubMed Central (United Kingdom)

The development of new methods for gene addition to mammalian genomes is necessary to overcome the limitations of conventional genetic engineering strategies. Although a variety of DNA-modifying enzymes...Full Text Available

2011-09-01

2

Can intensity-modulated radiation therapy of the paraaortic region overcome the problems of critical organ tolerance?  

International Nuclear Information System (INIS)

Background and purpose: the recent RTOG guidelines for future clinical developments in gynecologic malignancies included the investigation of dose escalation in the paraaortic (PO) region which is, however, very difficult to target due to the presence of critical organs such as kidneys, liver, spinal cord, and digestive structures. The aim of this study was to investigate intensity-modulated radiotherapy's (IMRT) possibilities of either increasing, in a safe way, the dose to 50-60 Gy in case of macroscopic disease or decreasing the dose to organs at risk (OR) when treatment is given in an adjuvant setting. Material and methods: the dosimetric charts of 14 patients irradiated to the PO region at the department of radiation oncology, university hospital of Liege, Belgium, in 2000 were analyzed in order to compare six-field conformal external-beam radio-therapy (CEBR) and five-beam IMRT approaches. Both CEBR and IMRT investigations were planned to ...

2005-03-01

3

Systematics of average radiative width of heavy nuclides  

Energy Technology Data Exchange (ETDEWEB)

Systematics of neutron capture radiative width were studied in the target element range from Th to Cm. Reduced radiative widths were analyzed with a simple radiative width formula based on E1 transition. Average radiative width is presented with the standard deviation of 15%. (author)

1999-03-01

4

Can intensity-modulated radiation therapy of the paraaortic region overcome the problems of critical organ tolerance?  

Energy Technology Data Exchange (ETDEWEB)

Background and purpose: the recent RTOG guidelines for future clinical developments in gynecologic malignancies included the investigation of dose escalation in the paraaortic (PO) region which is, however, very difficult to target due to the presence of critical organs such as kidneys, liver, spinal cord, and digestive structures. The aim of this study was to investigate intensity-modulated radiotherapy's (IMRT) possibilities of either increasing, in a safe way, the dose to 50-60 Gy in case of macroscopic disease or decreasing the dose to organs at risk (OR) when treatment is given in an adjuvant setting. Material and methods: the dosimetric charts of 14 patients irradiated to the PO region at the department of radiation oncology, university hospital of Liege, Belgium, in 2000 were analyzed in order to compare six-field conformal external-beam radio-therapy (CEBR) and five-beam IMRT approaches. Both CEBR and IMRT investigations were ...

2005-03-01

5

Variation in the Definition of Clinical Target Volumes for Pelvic Nodal Conformal Radiation Therapy for Prostate Cancer  

UK PubMed Central (United Kingdom)

PurposeWe conducted a comparative study of Clinical Target Volume (CTV) definition of pelvic lymph nodes by multiple GU radiation oncologists looking at the levels...Full Text Available

2009-06-01

6

Targeted nanoparticles that deliver a sustained, specific release of paclitaxel to irradiated tumors  

UK PubMed Central (United Kingdom)

To capitalize on the response of tumor cells to ionizing radiation, we developed a controlled-release nanoparticle drug delivery system using a targeting peptide that recognizes a radiation-induced...Full Text Available

2010-06-01

7

Heat Shock Protein 27-Targeted Heptapeptide of the PKC? Catalytic V5 Region Sensitizes Tumors With Radio- and Chemoresistance  

International Nuclear Information System (INIS)

Purpose: Previous data suggest that the PKC? catalytic V5 (PKC?-V5) heptapeptide (HEPT) (FEQFLDI) binds HSP27 and blocks HSP27-mediated radio- or chemoresistance. Here we investigated further the in vivo function of the PKC?-V5 HEPT. Methods and Materials: Labeling of HEPT with Cy5.5 or fluorescein isothiocyanate was performed to evaluate in vitro or in vivo distribution of HEPT. A clonogenic survival assay, flow cytometry, and Western blotting of cleaved caspase-3 were performed to determine in vitro sensitization effects of HEPT plus ionizing radiation (IR) versus IR alone or those of HEPT plus cisplatin(Cis) versus Cis alone. A nude mouse xenografting system was also applied to detect in vivo sensitizing effects of HEPT. Results: HEPT efficiently bound to HSP27 and showed sensitization after combined treatment with IR versus treatment with Cis alone in NCI-H1299 lung carcinoma cells, with higher HSP27 expression, which was similar to that of combined treatment ...

2011-05-01

8

Direct Stellar Radiation Pressure at the Dust Sublimation Front in Massive Star Formation: Effects of a Dust-free Disk  

Science.gov (United States)

In massive star formation (gsim 40 M sun) by core accretion, the direct stellar radiation pressure acting on the dust particles exceeds the gravitational force and interferes with mass accretion at the dust sublimation front, the first absorption site. Ram pressure generated by high accretion rates of 10-3 M sun yr-1 is thought to be required to overcome the direct stellar radiation pressure. We investigate the direct stellar irradiation on the dust sublimation front, including the inner accretion disk structure. We show that the ram pressure of the accretion disk is lower than the stellar radiation pressure at the dust sublimation front. Thus, another mechanism must overcome the direct stellar radiation pressure. We suggest that the inner hot dust-free region is optically thick, shielding the dust sublimation front from direct stellar irradiation. Thus, ...

2011-10-01

9

Radiation inactivation target size of rat adipocyte glucose transporters in the plasma membrane and intracellular pools  

Energy Technology Data Exchange (ETDEWEB)

The in situ assembly states of the glucose transport carrier protein in the plasma membrane and in the intracellular (microsomal) storage pool of rat adipocytes were assessed by studying radiation-induced inactivation of the D-glucose-sensitive cytochalasin B binding activities. High energy radiation inactivated the glucose-sensitive cytochalasin B binding of each of these membrane preparations by reducing the total number of the binding sites without affecting the dissociation constant. The reduction in total number of binding sites was analyzed as a function of radiation dose based on target theory, from which a radiation-sensitive mass (target size) was calculated. When the plasma membranes of insulin-treated adipocytes were used, a target size of approximately 58,000 daltons was obtained. For adipocyte microsomal membranes, we obtained ...

1987-06-15

10

Transverse Coherence Properties of the LCLS X-Ray Beam  

Science.gov (United States)

Self-amplifying spontaneous radiation free-electron lasers, such as the LCLS or the European X-FEL, rely on the incoherent, spontaneous radiation as the seed for the amplifying process. Though this method overcomes the need for an external seed source one drawback is the incoherence of the effective seed signal. The FEL process allows for a natural growth of the coherence because the radiation phase information is spread out within the bunch due to slippage and diffraction of the radiation field. However, at short wavelengths this spreading is not sufficient to achieve complete coherence. In this presentation we report on the results of numerical simulations of the LCLS X-ray FEL. From the obtained radiation field distribution the coherence properties are extracted to help to characterize the FEL as a light source.

2007-04-16

11

Experiments to investigate the effects of radiative cooling on plasma jet collimation  

CERN Document Server

Preliminary experiments have been performed to investigate the effects of radiative cooling on plasma jets. Thin (3 um - 5 um) conical shells were irradiated with an intense laser, driving jets with velocities > 100 km/s. Through use of different target materials - aluminium, copper and gold - the degree of radiative losses was altered, and their importance for jet collimation investigated. A number of temporally resoved optical diagnostics was used, providing information about the jet evolution. Gold jets were seen to be narrower than those from copper targets, while aluminium targets produced the least collimated flows.

2010-01-01

12

Measured Temperatures of Solid Rocket Motors Dump Stored ...  

Science.gov (United States)

... TARGET SENSOR-MK 80 SERIES BOMBS ... 5-inch-, and 2.75-inch- diameter rocket motors that ... balance when compared to incoming solar radiation ...

1989-07-01

13

Use of integrin-linked kinase to extend function of encapsulated pancreatic tissue  

Energy Technology Data Exchange (ETDEWEB)

We have studied the impact of overexpression of an intracellular signaling protein, integrin-linked kinase (ILK), on the survival and function of encapsulated islet tissue used for the treatment of type 1 diabetes. The dimensions of the encapsulated tissue can impact the stresses placed on the tissue and ILK overexpression shows the ability to extend function of dissociated cells as well as intact islets. These results suggest that lost cell-extracellular matrix interactions in cell encapsulation systems can lead to decreased insulin secretion and ILK signaling is a target to overcome this phenomenon. (communication)

2010-12-15

14

A He-gas Cooled, Stationary Granular Target  

CERN Document Server

In the CERN approach to the design of a neutrino factory, the repetition frequency of the proton beam is high enough to consider stationary solid targets as a viable solution for multi-MW beams. The target consists of high density tantalum spheres of 2 mm diameter which can efficiently be cooled by passing a high mass flow He-gas stream through the voids between the Ta-granules. Very small thermal shocks and stresses will arise in this fine grained structure due to the relatively long burst of 3.3 ms from the SPL-proton linac. In a quadruple target system where each target receives only one quarter of the total beam power of 4 MW, conservative temperature levels and adequate lifetimes of the target are estimated in its very high radiation environment. A conceptual design of the integration of the target into the magnetic horn-pion-collector ...

2003-01-01

15

Practical applications and feasibility of efflux pump inhibitors in the clinic-A vision for applied use  

British Library Electronic Table of Contents (United Kingdom)

The world of antibiotic drug discovery and development is driven by the necessity to overcome antibiotic resistance in common Gram-positive and Gram-negative pathogens. However, the lack of Gram-negative activity among both recently approved antibiotics and compounds in the developmental pipeline is a general trend despite the fact that the plethora of covered drug targets are well-conserved across the bacterial kingdom. Such intrinsic resistance in Gram-negative bacteria is largely attributed to the activity of multidrug resistance (MDR) efflux pumps. Moreover, these pumps also play a significant role in acquired clinical resistance. Together, these considerations make efflux pumps attractive targets for inhibition in that the resultant efflux pump inhibitor (EPI)/antibiotic combination d...

2006-01-01

16

Conformal radiation therapy: technical requirements and clinical applications  

International Nuclear Information System (INIS)

Conformal radiation therapy represents a considerable and attractive challenge in oncology. Its aim is mainly to improve local control by increasing the dose with an acceptable rate of complications. This work overviews the world literature on this subject. The technical and theoretical requirements are highlighted. These requirements include a precise definition of the target volume by digital imaging (essentially CT scan), but also clear view of the target volume and the organs at risk, a specific collimation of the beam, 3-D dose calculations, optimization procedures, and a rigid immobilization of the patient with verification of his position. Moreover, the clinical applications of conformal radiation therapy are reviewed and discussed. (authors). 80 refs., 1 tab.

1995-01-01

17

Evaluation of the residual radiation field in the proton accelerator facility of the Proton Engineering Frontier Project (PEFP) in Korea  

British Library Electronic Table of Contents (United Kingdom)

In Korea, the Proton Engineering Frontier Project (PEFP) is building a proton linear accelerator facility with energy up to 100MeV and a beam current of 20mA. In this study, a radiation field after shutdown in the accelerator facility of the PEFP was evaluated for the purpose of the radiation shielding by using MCNPX code. A facility modeling was performed for the accelerator tunnel building, accelerator chain, target rooms and beam experiment hall. And radiation source terms were evaluated in the facility. With this facility, model and radiation source terms, the concentration of 41Ar was evaluated and the cooling time satisfying regulation in Korea was calculated.

2007-01-01

18

Assessment of the efficacy of braking radiation beam formation of electron accelerators  

International Nuclear Information System (INIS)

Proceeding from analysis of the influence of parameters of the target-filter system on radiation-physical characteristics of braking radiation, some recommendations were issued for assessment of the forming systems of medical accelerators of electrons. A new criterion - a coefficient of the forming system efficacy - was introduced, characterizing a beam formation tract with relation to a whole set of radiotherapeutic problems.

19

Detached divertor plasmas in JET  

Energy Technology Data Exchange (ETDEWEB)

In simulations with high radiated power fractions, it is possible to produce the drop in ion current to the divertor targets typical of detached plasmas. Despite the fact that these experiments are performed on beryllium target tiles, radiation from deuterium and beryllium cannot account for the measured power losses. The neutral deuterium levels in the SOL in these plasmas are higher than the model predicts. This may be due to leakage from the divertor or to additional wall sources related to the non-steady nature of these plasmas. In contrast, a surprisingly high level of carbon is present in these discharges; higher even than would be predicted are the divertor target tiles pure carbon. This level may well be large enough to produce the measured radiation. (authors). 6 refs., 2 figs., 1 tab.

1994-07-01

20

Ageing of fibre reinforced polymer composite selected as a bearing material for Rams of 540 MWe fuelling machine  

International Nuclear Information System (INIS)

Fibre-reinforced-polymer-composite material has been suggested as a bearing material to overcome tribological problems witnessed during the testing of Ram assembly of the 540 MWe fuelling machine at RTD. After successful trials at B-Ram the composite material has been adapted for B-RAM, C-Ram and RDB head at fuelling machines being tested at RTD, Hall 7 and at Tarapur. Laboratory evaluations were also carried out at Tribology Lab RTD to study effect of radiation on the composite. Paper deals with the various aspects of life prediction of this material in term of wear and radiation damage. (author)

2006-11-01

21

Effects of ion-induced electron emission on magnetron plasma instabilities  

International Nuclear Information System (INIS)

Some magnetron sputtering systems experience rapid oscillations in the current and voltage of the plasma discharge after several hours when equipped with certain targets. These oscillations often lead to the plasma becoming extinguished, a condition known as ''flame-out.'' This article details the study of two 90% W--10% Ti magnetron targets which differed in density. The higher density targets sometimes experienced flame-out after approximately 3 h of sputtering. The less dense material could be sputtered for the entire 15 h life of the target. Scanning electron microscopy pictures and atomic composition depth profiles were obtained using Auger electron spectroscopy. In addition, a Colutron-based ion source with a high vacuum system was used to measure ion-induced secondary electron emission coefficients as a function of energy, ion specie, and gas coverage. Analysis of the sample from the group that ...

22

What's new in target volume definition for radiologists in ICRU Report 71? How can the ICRU volume definitions be integrated in clinical practice?  

UK PubMed Central (United Kingdom)

AbstractThe optimal definition of the size, shape and location of gross tumour volume is one of the most important steps in the planning of radiation therapy, and necessitates a proper...Full Text Available

23

Stem cell niches and other factors that influence the sensitivity of bone marrow to radiation-induced bone cancer and leukaemia in children and adults  

UK PubMed Central (United Kingdom)

Purpose: This paper reviews and reassesses the internationally accepted niches or ‘targets’ in bone marrow that are sensitive to the induction of leukaemia and primary...Full Text Available

2011-04-01

24

Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine  

CERN Document Server

This book examines the applications of Monte Carlo (MC) calculations in therapeutic nuclear medicine, from basic principles to computer implementations of software packages and their applications in radiation dosimetry and treatment planning. It is written for nuclear medicine physicists and physicians as well as radiation oncologists, and can serve as a supplementary text for medical imaging, radiation dosimetry and nuclear engineering graduate courses in science, medical and engineering faculties. With chapters is written by recognised authorities in that particular field, the book covers the entire range of MC applications in therapeutic medical and health physics, from its use in imaging prior to therapy to dose distribution modelling targeted radiotherapy. The contributions discuss the fundamental concepts of radiation dosimetry, radiobiological aspects of ...

2003-01-01

25

Report on NCI symposium: comparison of mechanisms of carcinogenesis by radiation and chemical agents. II. Cellular and animal models  

International Nuclear Information System (INIS)

The point at which the common final pathway for induction of cancer by chemical carcinogens and ionizing radiation has not been identified. Although common molecular targets are suggested by recent findings about the role of oncogenes, the mechanism by which the deposition of radiation energy and the formation of adducts or other DNA lesions induced by chemicals affects the changes in the relevant targets may be quite different. The damage to DNA that plays no part in the transformation events, but that influences the stability of the genome, and therefore, the probability of subsequent changes that influence tumorigenesis may be more readily induced by some agents than others. Similarly, the degree of cytotoxic effects that disrupt tissue integrity and increase the probability of expression of initiated cells may be dependent on the type of carcinogen. Also, evidence was presented that repair of the ...

1984-05-20

26

Radiation therapy and Ewing's sarcoma in childhood  

International Nuclear Information System (INIS)

Despite high local control rate in Ewing's sarcoma the exact indication of radiation therapy is still controversial as well as the choice of the target volume and the optimal dose of radiation. The importance of the quality of radiotherapy has been stressed in recently published data and has shown a significant impact on long term local control with adequate radiation therapy. The dramatic improvement of precision allowed by the conformal therapy and three dimensional dosimetry allow to expect a decrease of late effects expected for second malignancies. However, late sequelae and radio-induced osteosarcoma still remain the major side effects after radiotherapy. The authors discuss the results of the main trials on Ewing's sarcoma on the choice of dose and target volume. Surgery is still the preferred choice for small tumors if the foreseen outcome is identical. (authors). 28 refs.

27

Experimental research on X-ray spectrum emitted from hot laser-produced aluminium plasma  

International Nuclear Information System (INIS)

The hot uniform aluminium plasma was produced by irradiating thin aluminium dotted foil smoothly with the 9th 0.53 ?m laser on Shenguang II laser facility. The emitted spectrum was measured from the front and tangential direction of the target with two crystal spectrometers, and the quantitative spectrum from the front of the target was obtained. The state of laser- produced plasma was simulated with the radiation hydrodynamics code MULTI-1D, and the emitted spectrum was calculated with the spectrum code of Collision-Radiation model under the simulated plasma state. The experimental spectrum accords with the simulated one. (authors)

2007-12-01

28

Implementation of improved interactive image analysis at the Advanced Photon Source (APC) linac.  

Energy Technology Data Exchange (ETDEWEB)

An image-analysis system, based on commercially available data visualization software (IDL [1]), allows convenient interaction with image data while still providing calculated beam parameters at a rate of up to 2 Hz. Image data are transferred from the IOC to the workstation via EPICS [2] channel access. A custom EPICS record was created in order to overcome the channel access limit of 16k bytes per array. The user can conveniently calibrate optical transition radiation (OTR) and fluorescent screens, capture background images, acquire and average a series of images, and specify several other filtering and viewing options. The images can be saved in either IDL format or APS-standard format (SDDS [3]), allowing for rapid postprocessing of image data by numerous other software tools.

1998-09-11

29

Development of functional foods for radiation workers  

Energy Technology Data Exchange (ETDEWEB)

In searching modulators of immunity and hematopoiesis among natural products, being used as foods, six herbs exhibited lymphocyte proliferation in vitro, and six exhibited augmentation of hematopoietic cell growth. The combined treatments showed synergistic effects of lymphocyte proliferation and of hematopoietic cell growth. On the other hand, we found four effective oriental medicinal prescriptions, used as energy tonic or blood-building decoctions, for survival and regeneration of hematopoietic cells and for protection of stem cells of intestinal crypt in irradiated mice. On the basis of these results, extracts from combinations of herbs were made in expectation of higher effects in the three respects. In immuno modulation activity by the two combinations of herbs was confirmed in mice. In culture of bone narrow cells, growth improvement of non-adherent precursor and induction of cytokine expression by herb mixture extracts were observed. In evaluation of fractions, polysaccharide ...

2000-03-01

30

The wavelength dependence of ultraviolet enhanced reactivation in a mammalian cell-virus system  

International Nuclear Information System (INIS)

The effect of UV radiation in the wavelength region 230 nm to 302 nm on the ability of an irradiated mammalian cell to reactivate UV-irradiated mammalian virus was tested. An action spectrum for radiation enhanced reactivation (RER) is presented. The shape of the action spectrum points to a combined nucleic acid-protein target for UV radiation effects on this cellular parameter. An analysis of the results of others involving the biochemical and photobiological events involved in RER does not allow us to distinguish which macromolecule is the major contributor to this effect. Studies involving an analogous phenomenon in bacteris (Weigle reactivation) imply that RER and WR amy involve similar mechanisms. (author).

31

Numerical simulation and experiment research of radiation performance in a dish solar collector system  

British Library Electronic Table of Contents (United Kingdom)

The Monte Carlo ray-tracing method is applied and coupled with optical properties to predict the radiation performance of solar concentrator/cavity receiver systems. Several different cavity geometries are compared on the radiation performance. A flux density distribution measurement system for dish parabolic concentrators is developed. The contours of the flux distribution for target placements at different distances from the dish vertex of a solar concentrator are taken by using an indirect method with a Lambert and a charge coupled device (CCD) camera. Further, the measured flux distributions are compared with a Monte Carlo-predicted distribution. The results can be a valuable reference for the design and assemblage of the solar collector system.

2010-01-01

32

Beam lifetime and emittance growth in RHIC under normal operating conditions with the hydrogen gas jet, the cluster-jet and pellet targets  

International Nuclear Information System (INIS)

The inelastic scattering of the beam and the residual gas molecules in RHIC could represent one of the limitations on the beam life time and emittance growth. This report covers the dominant central nuclear collisions influence on the beam lifetime and transverse emittance growth. The cross sections for the beam-gas electron radiative captures are an order of magnitude smaller. The capture cross sections include the radiative and non-radiative capture, and the capture from the electron-positron pair creation from the 'vacuum capture'.

2010-09-01

33

The ecology of software configuration management  

Energy Technology Data Exchange (ETDEWEB)

This paper discusses how to overcome failures and pitfalls in software configuration management. (LSP)

1988-01-01

34

Measurement of K x-ray intensity ratio of tin, gadolinium and dysprosium  

International Nuclear Information System (INIS)

Full text: Measurement of K_#beta# to K_#alpha# x-ray intensity ratios are important not only in the field of atomic physics, radiation physics and medical physics, but also to test the validity of assumptions made in the theoretical prediction. The intensity ratios can also give information on the effect of physical and chemical environment of the element in the compound. Many investigators have adopted a single and double reflection geometries to measure the K_#beta# to K_#alpha# x ray intensity ratios to understand the effect of physical and chemical environment on x-ray fluorescence. The targets are excited by a radioactive source of having activity of the order 100 MBq. in order to carry out accurate measurement K_#beta# to K_#alpha# x-ray intensity ratios, we have develop 2#pi# geometrical configuration method : placing a target right on the surface of the detector facing the target to measure the ...

2003-11-01

35

Distributed radiation protection console system  

International Nuclear Information System (INIS)

Radiation exposure control is one of the most important aspects in any nuclear facility . It encompasses continuous monitoring of the various areas of the facility to detect any increase in the radiation level and/or the air activity level beyond preset limits and alarm the O and M personnel working in these areas. Detection and measurement of radiation level and the air activity level is carried out by a number of monitors installed in the areas. These monitors include Area Gamma Monitors, Continuous Air Monitors, Pu-In-Air Monitors, Criticality Monitors etc. Traditionally, these measurements are displayed and recorded on a Central Radiation Protection Console(CRPC), which is located in the central control room of the facility. This methodology suffers from the shortcoming that any worker required to enter a work area will have to inquire about the radiation status of the area ...

2004-02-01

36

Is uniform target dose possible in IMRT plans in the head and neck?  

International Nuclear Information System (INIS)

Purpose: Various published reports involving intensity-modulated radiotherapy (IMRT) plans developed using automated optimization (inverse planning) have demonstrated highly conformal plans. These reported conformal IMRT plans involve significant target dose inhomogeneity, including both overdosage and underdosage within the target volume. In this study, we demonstrate the development of optimized beamlet IMRT plans that satisfy rigorous dose homogeneity requirements for all target volumes (e.g., #+-#5%), while also sparing the parotids and other normal structures. Methods and Materials: The treatment plans of 15 patients with oropharyngeal cancer who were previously treated with forward-planned multisegmental IMRT were planned again using an automated optimization system developed in-house. The optimization system allows for variable sized beamlets computed using a three-dimensional convolution/superposition dose ...

2002-04-01

37

Radiation-hardening of magnet coils  

International Nuclear Information System (INIS)

The first essential before embarking on the radiation-hardening of electrical insulation - mostly magnet coils - in any beam line application is to obtain a reliable estimate of the dose to the components. These are examples ( switchyards at SLAC and LAMPF) where the degree of hardness specified was much higher than was required. Although experience shows that the cost premium for substantial radiation - hardening is of the order of 10%, it has also become clear that well - designed beam line have negligible losses: hardening is required only in the vicinity of targets, collimators or other beam - intercepting devices. Where the beam is deliberately scraped, local shielding will minimize the associated radiation in the surroundings. Electron machines have their own special problems due to synchrotron radiation, so certainly coils and other electrical equipment should be kept away ...

1989-03-01

38

Electron beam therapy in carcinoma of the buccal mucosa  

Energy Technology Data Exchange (ETDEWEB)

Electron beam therapy has often been used for radiation therapy of carcinomas of the buccal mucosa, though side effects, including stomatitis and dermatitis, are known to exist. We experimented using the additional back scatter and transit with the phantom under a lead plate within the irradiation field, in order to better focus the dose on the target volume moreover, we fabricated a mouthpiece fitted with a lead plate shaped to the target volume, and with respect to the influence of the mouthpiece on stomatitis and dermatitis, obtained good clinical results. (author).

1990-10-01

39

Electron beam therapy in carcinoma of the buccal mucosa  

International Nuclear Information System (INIS)

Electron beam therapy has often been used for radiation therapy of carcinomas of the buccal mucosa, though side effects, including stomatitis and dermatitis, are known to exist. We experimented using the additional back scatter and transit with the phantom under a lead plate within the irradiation field, in order to better focus the dose on the target volume moreover, we fabricated a mouthpiece fitted with a lead plate shaped to the target volume, and with respect to the influence of the mouthpiece on stomatitis and dermatitis, obtained good clinical results. (author).

40

Study on the stability of the Maytenus aquifolium Martius chemical components submitted to ionizing radiation (X-ray and #gamma#)  

International Nuclear Information System (INIS)

The interest for medicinal plants has raised again in the last decades, after overcoming a declination period caused by the advances in the researches and development of the synthetic drugs industries. This growing interest has been stimulated mainly by searching cheap and accessible alternative therapies. However, in order to have natural products based treatment in an efficient and safety way, it is necessary to guarantee the plant authenticity, finding adulterations and to assure a low level of microbiological contaminations to avoid damages to consumer's health. The decontamination method should be chosen for eliminating or reduce the microorganisms level without loss of the plant active constituents that would destroy its therapeutic action. At the present work, the possibility of using #gamma# and X electromagnetic radiations to sterilize a Brazilian medicinal plant (Maytenus aquifolium Martius, Celastraceae), which shows anti-ulcer ...

41

Donut-shaped high-dose configuration for proton beam radiation therapy  

Energy Technology Data Exchange (ETDEWEB)

Background: the authors report on the conception and first clinical application of a donut-shaped high-dose configuration for proton therapy (PT). This approach allows one to intensify target volume dose coverage for targets encompassing a critical, dose-limiting structure - like here, the cauda equina -, whilst delivering minimal dose to other healthy structures surrounding the target, thereby reducing the integral dose. Methods and results: intensity-modulated PT methods (IMPT) for spot scanning were applied to create and deliver a donut-shaped high-dose configuration with protons, allowing treating > 75% of the target with at least 95% of the prescribed dose of 72.8 CGE, whilst restricting dose to the cauda equina to 60-65 CGE. Integral dose was lower by a factor of 3.3 as compared to intensity-modulated radiotherapy with photons (IMXT). Conclusion: IMPT and spot scanning technology allow a ...

2005-01-01

42

Donut-shaped high-dose configuration for proton beam radiation therapy  

International Nuclear Information System (INIS)

Background: the authors report on the conception and first clinical application of a donut-shaped high-dose configuration for proton therapy (PT). This approach allows one to intensify target volume dose coverage for targets encompassing a critical, dose-limiting structure - like here, the cauda equina -, whilst delivering minimal dose to other healthy structures surrounding the target, thereby reducing the integral dose. Methods and results: intensity-modulated PT methods (IMPT) for spot scanning were applied to create and deliver a donut-shaped high-dose configuration with protons, allowing treating > 75% of the target with at least 95% of the prescribed dose of 72.8 CGE, whilst restricting dose to the cauda equina to 60-65 CGE. Integral dose was lower by a factor of 3.3 as compared to intensity-modulated radiotherapy with photons (IMXT). Conclusion: IMPT and spot scanning technology allow a ...

2005-01-01

43

A proposed scheme for coal fired combined cycle and its concise performance  

Energy Technology Data Exchange (ETDEWEB)

For IGCC, the primary investment is too high due to the demand of high gasification efficiency. For PFBCC, the thermal efficiency is too low due to the relatively low turbine inlet temperature and the hot working medium of the gas turbine is not easy to clean. A new scheme is proposed for coal fired combined cycle to overcome the main drawbacks of IGCC and PFBCC. The research targets are developing a new cycle construction of coal fired combined cycle to raise the efficiency and reduce the primary investment. Actually, the new scheme is a synthesis of some existing proposals. It adopts partial gasification to reduce the primary investment of the gasification equipment. The un-gasified surplus solid is then fed to a pressurized fluidized bed boiler, but adopting Curtiss Wright type external combustion to lower the ash content in the working medium. The gas fuel from the partial gasifier is combusted in a top combustor to further increase the ...

2007-06-15

44

PIC Simulations Of Ion Acceleration By Linearly And Circularly Polarized Laser Pulses  

Science.gov (United States)

Linearly polarized laser radiation accelerates electrons to very high velocities and these electron form a sheath layer on the rear side of thin targets where preferentially protons are accelerated. When mass-limited targets are used, the lateral transport of the absorbed laser energy is reduced and the accelerating field is enhanced. For targets consisting of two ion species, heavier ions facilitate formation of quasi-monoenergetic bunch of lighter ions. For circularly polarized light, fast electron production is suppressed by the absence of the oscillatory component of the ponderomotive force. Ions are accelerated on the front side by the separation field and very thin foil can be accelerated as one massive quasi-neutral block. As all ion species acquire the same velocity, this acceleration mechanism is preferred for heavier ions.

2008-06-24

45

Pulse source of electron and X-ray radiations of subnanosecond duration  

International Nuclear Information System (INIS)

The time and dose characteristics of the electron and X-ray radiations of a tube, connected to a subnanosecond mega volt accelerator, are measured. By the pulse of the accelerating voltage of #>=# 600 kV with duration of #approx =# 0.3 ns the tube generates approximately 5 x 10"1"2 electrons pulse. The current amplitude equals approximately 5 kA/pulse and the radiation dose-about 5 kGy/pulse. The X-ray radiation dose from the tantalum external target constitutes 0.15 Gy/pulse. The prototypes of the electron and X-ray tubes sufficiently lower volumes, opening new applications in the technique and medicine, are developed

46

Free electron laser inertial thermonuclear synthesis  

International Nuclear Information System (INIS)

The paper proposes a concept of power driver for industrial thermonuclear reactor based on inertial thermonuclear synthesis (ITS). The circuit is based on the application of free electron laser (FEL) as a energy source for thermonuclear target compression which becomes feasible due to the application of a radically new circuit of FEL-amplifier. In the project under consideration the FEL-based laser system operates on the wave length of 0.5 micrometer. The full energy of laser radiation equals 1 MJ. This energy is delivered to the target in the pulse whose length is controlled within the range of 0.1-2 ns. The laser system brightness is 4 x 10"2"2 W cm"-"2. The FEL operating pulse repetition frequency is 40 Hz, full efficiency of electricity conversion into the energy of optical radiation is 11%. 9 refs., 3 figs., 2 tabs.

47

Patient doses in the Netherlands. [X-ray diagnosis and radiotherapy  

Energy Technology Data Exchange (ETDEWEB)

Contributions to the population dose due to medical applications of ionising radiation are presented. It appears that contributions due to radiotherapy and X ray diagnosis are of comparable magnitude. To account for the age dependency of the radiation risks, contributions in terms of somatically significant dose equivalent are calculated as 0.3 mSv per caput per annum for X ray diagnosis and as 0.2 mSv per caput per annum for radiotherapy, the latter referring to only doses to organs outside the target volume. (author).

1991-01-01

48

Automatic beam position control at Los Alamos Spallation Radiation Effects Facility (LASREF)  

Energy Technology Data Exchange (ETDEWEB)

Historically the Los Alamos Spallation Radiation Effects Facility (LASREF) has used manual methods to control the position of the 800 kW, 800 MeV proton beam on targets. New experiments, however, require more stringent position control more frequently than can be done manually for long periods of time. Data from an existing harp is used to automatically adjust steering magnets to maintain beam position to required tolerances.

1997-08-01

49

Radiation inactivation target size of rat adipocyte glucose transporter  

Energy Technology Data Exchange (ETDEWEB)

In situ assembly states of rat adipocyte glucose transport protein in plasma membrane (PM) and in microsomal pool (MM) were assessed by measuring target size (TS) of D glucose-sensitive, cytochalasin B binding activity. High energy radiation inactivated the binding in both PM and MM by reducing the total capacity of the binding (B/sub T/) without affecting the dissociation constant (K/sub D/). The reduction in B/sub T/ as a function of radiation dose was analyzed based on classical target theory, from which TS was calculated. TS in the PM of insulin-treated adipocytes was 58 KDa. TS in the MM of noninsulin-treated and insulin-treated adipocytes were 112 and 109 KDa, respectively. With MM, however, inactivation data showed anomalously low radiation sensitivities at low radiation doses showing a shoulder in the semilog plots, which may be due to an interaction ...

1987-05-01

50

Spectroscopic investigation of the charge dynamics of heavy ions penetrating solid and gaseous targets  

Energy Technology Data Exchange (ETDEWEB)

This thesis presents the study of the slowing down process of fast heavy ions inside matter. In the framework of this research, the influence of the target density on the stopping process is investigated. Experiments on the interaction of {sup 48}Ca{sup 6+}-{sup 48}Ca{sup 10+} and {sup 26}Mg{sup 5+} ion beams with initial energies of 11.4 MeV/u and 5.9 MeV/u with solid and gaseous targets have been carried out. A novel diagnostic method, X-ray spectroscopy of K-shell projectile radiation, is used to determine the ion charge state in relation to its velocity during the penetration of fast heavy ions inside the stopping material. A spatially resolved analysis of the projectile and target radiation in solids is achieved for the first time. The application of low-density silica aerogels as stopping media provided a stretching of the ion stopping length by 20 - 100 times in comparison ...

2007-01-15

51

Final report of the specific research. Investigations on the analysis of bio-protective factors against radiation. 1998-2000 FY (Research Group of NIRS)  

Energy Technology Data Exchange (ETDEWEB)

This report concerns investigations in the title conducted by 8 groups of National Institute of Radiological Sciences (NIRS) during the period of 1998-2000. The groups are for investigation of: Effects of p53 tumor suppressor gene in radiation-induced leukemia, Role of atm-gene in dose rate effect of ionizing radiation, Function of DNA-dependent protein kinase catalytic subunit (DNA-PK{sub cs}), Functional complementation of radiation-sensitive mutant M10 cell line by human XRCC4 cDNA expression, Role of radiation-induced apoptosis in digital defects in embryonic mice, Functional analysis of S-phase specific novel nuclear protein NP95 by gene targeting, Role of chemokine in T cell development and lymphomagenesis, and establishment of production techniques of gene-modified mice using embryonic stem cells for genetic analysis of radiation-sensitive genes. The ...

2002-03-01

52

Environmentally-Induced Malignancies: An In Vivo Model to Evaluate the Health Impact of Chemicals in Mixed Waste  

Energy Technology Data Exchange (ETDEWEB)

Occupational and environmental exposure to organic ligands, solvents, fuel hydrocarbons, and polychlorinated biphenyls are linked with increased risk of hematologic malignancies. DOE facilities and waste sites in the U.S. are contaminated with mixtures of potentially hazardous chemicals such as metals, organic ligands, solvents, fuel hydrocarbons, polychlorinated biphenyls and radioactive isotopes. A major goal of this project was to establish linkage between chemical/radiation exposure and induction of genomic damage in target populations with the capability to undergo transformation.

2001-05-04

53

Exercise Decreases Myelin-Associated Glycoprotein Expression in the Spinal Cord and Positively Modulates Neuronal Growth  

UK PubMed Central (United Kingdom)

To successfully grow, neurons need to overcome the effects of hostile environments, such as the inhibitory action of myelin. We have evaluated the potential of exercise to overcome the intrinsic...Full Text Available

2007-07-01

54

Four Forces on a Rocket - NASA  

Science.gov (United States)

On an airplane, the lift force (the aerodynamic force perpendicular to the flight direction) is used to overcome the weight. On a rocket, thrust is used in opposition ...

55

Materials considerations for the National Spallation Neutron Source target  

Energy Technology Data Exchange (ETDEWEB)

The National Spallation Neutron Source (NSNS), in which neutrons are generated by bombarding a liquid mercury target with 1 GeV protons, will place extraordinary demands on materials performance. The target structural material will operate in an aggressive environment, subject to intense fluxes of high energy protons, neutrons, and other particles, while exposed to liquid mercury and to water. Components that require special consideration include the Hg liquid target container and protective shroud, beam windows, support structures, moderator containers, and beam tubes. In response to these demands a materials R and D program has been developed for the NSNS that includes: selection of materials; calculations of radiation damage; irradiations, post irradiation testing, and characterization; compatibility testing and characterization; design and implementation of a plan for monitoring of materials ...

1997-08-01

56

The preliminary success of ALARA implementation in Daya Bay NPP  

International Nuclear Information System (INIS)

Based on the practical condition of the plant and in reference to advanced management experiences worldwide, Daya Bay Nuclear Power Plant has established its own peculiar management system for radiation protection management and ALARA implementation. The characteristics of the system are: radiation protection training to all workers, active involvement of all managers and staffs, and whole process safety control to maintenance activities. The management philosophy of 'workers are responsible for their own radiation safety' is adopted in the plant. A strict, formalized and systematic whole staff radiation protection training, evaluation, authorization and periodically refreshing mechanism had been established and executed in the plant. In the organizational point of view, the responsibilities of line managers were specified in plant procedures, ALARA coordination organization on plant level and for ...

2000-05-01

57

Overview of the recent activities of the RD50 collaboration on radiation hardening of semiconductor detectors for the sLHC  

International Nuclear Information System (INIS)

The RD50 collaboration has been exploring the development of radiation hard semiconductor devices for very high-luminosity colliders since 2002. The target fluence to qualify detectors set by the anticipated dose for the innermost tracking layers of the future upgrade of the CERN large hadron collider (LHC) is 1016 1 MeV neutron equivalent (neq) cm-2. This is about an order of magnitude higher than the maximum dose for the most exposed silicon detectors in the current machine. RD50 investigates the radiation hardening of silicon sensors from many angles: improvement of the intrinsic tolerance of the substrate material, optimisation of the readout geometry and study of novel design of detectors. A review of some of the recent activities within RD50 is here presented.

2009-01-01

58

Overview of the recent activities of the RD50 collaboration on radiation hardening of semiconductor detectors for the sLHC  

British Library Electronic Table of Contents (United Kingdom)

The RD50 collaboration has been exploring the development of radiation hard semiconductor devices for very high-luminosity colliders since 2002. The target fluence to qualify detectors set by the anticipated dose for the innermost tracking layers of the future upgrade of the CERN large hadron collider (LHC) is 1016 1MeV neutron equivalent (neq) cm-2. This is about an order of magnitude higher than the maximum dose for the most exposed silicon detectors in the current machine. RD50 investigates the radiation hardening of silicon sensors from many angles: improvement of the intrinsic tolerance of the substrate material, optimisation of the readout geometry and study of novel design of detectors. A review of some of the recent activities within RD50 is here presented.

2009-01-01

59

X-ray phase imaging using a X-ray tube with a small focal spot. Improvement of image quality in mammography  

International Nuclear Information System (INIS)

Phase contrast X-ray imaging has been studied intensively using X-rays from synchrotron radiation and micro-focus X-ray tubes. However, these studies have revealed the difficulty of this technique's application to practical medical imaging. We have created a phase contrast imaging technique using a molybdenum X-ray tube with a small focal spot size for mammography. We identified the radiographic conditions in phase contrast magnification mammography with a screen-film system, where edge effect due to phase contrast overcomes geometrical unsharpness caused by the 0.1 mm-focal spot of a molybdenum X-ray tube. The edge enhancement due to phase imaging was observed in an image of a plastic tube, and then geometrical configuration of the X-ray tube, the object and the screen-film system was determined for phase imaging of mammography. In order to investigate a potential for medical application of this method, we conducted evaluation of the images of ...

2002-03-01

60

Structural transformations in Sc/Si multilayers irradiated by EUVlasers  

Energy Technology Data Exchange (ETDEWEB)

Multilayer mirrors for the extreme ultraviolet (EUV) are keyelements for numerous applications of coherent EUV sources such as newtabletop lasers and free-electron lasers. However the field ofapplications is limited by the radiation and thermal stability of themultilayers. Taking into account the growing power of EUV sources thestability of the optics becomes crucial. To overcome this problem it isnecessary to study the degradation of multilayers and try to increasetheir temporal and thermal stability. In this paper we report the resultsof detailed study of structural changes in Sc/Simultilayers when exposedto intense EUV laser pulses. Various types of surface damage such asmelting, boiling, shockwave creation and ablation were observed asirradiation fluencies increase. Cross-sectional TEM study revealed thatthe layer structure was completely destroyed in the upper part ofmultilayer, but still survived below. The layers adjacent tothe ...

2007-08-21

61

TLD array for precise dose measurements in stereotactic radiation techniques  

International Nuclear Information System (INIS)

We developed a new TLD array for precise dose measurement and verification of the spatial dose distribution in small radiation targets. It consists of a hemicylindrical, tissue-equivalent rod made of polystyrene with 17 parallel moulds for an exact positioning of each TLD. The spatial resolution of the TLD array was evaluated using the Leskell spherical phantom. Dose planning was performed with KULA 4.4 under stereotactic conditions on axial CT images. In the Leksell gamma unit the TLD array was irradiated with a maximal dose of 10 Gy with an unplugged 14 mm collimator. The doses delivered to the TLDs were rechecked by diode detector and film dosimetry and compared to the computer-generated dose profile. We found excellent agreement of our measured values, even at the critical penumbra decline. For the 14 mm and 18 mm collimator and for the 11 mm collimator combination we compared the measured and calculated data at full width at half maximum. ...

1996-12-01

62

Detection of high-frequency radiation sources during the 2004 Parkfield earthquake by a matched filter analysis  

Science.gov (United States)

Introduction Uchide and Ide [SSA Spring Meeting, 2009] proposed a new framework for studying the scaling and overall nature of earthquake rupture growth in terms of cumulative moment functions. For better understanding of rupture growth processes, spatiotemporally local processes are also important. The nature of high-frequency (HF) radiation has been investigated for some time, but its role in the earthquake rupture process is still unclear. A wavelet analysis reveals that the HF radiation (e.g., 4 - 32 Hz) of the 2004 Parkfield earthquake is peaky, which implies that the sources of the HF radiation are isolated in space and time. We experiment with applying a matched filter analysis using small template events occurring near the target event rupture area to test whether it can reveal the HF radiation sources for a regular large earthquake. Method We design a matched filter for ...

2009-12-01

63

Low temperature partly ionized plasma in magnetic fusion devices: Present status and prospects  

Energy Technology Data Exchange (ETDEWEB)

The most striking achievement in magnetic fusion experiments during last few years was the discovery of plasma detachment from material targets, a much needed effect for plasmas with high power fusion parameters. Due to the very low heat loads on the targets observed in these regimes and potentially low erosion of the targets, detached regimes look attractive from the International Thermonuclear Experimental Reactor (ITER) design point of view. Thus the author has experimental proof for the possibility for a co-existence of fusion relevant hot plasma in the core and a low temperature partly ionized plasma at the edge of magnetic fusion device. Although somewhat similar behavior of edge plasma was considered theoretically even before plasma detachment was found experimentally, it was not clear in the beginning how these theoretical and experimental findings would fit together. Now, after a few years of intensive additional ...

1998-12-31

64

Ion-induced M X-ray emission from heavy lanthanides  

International Nuclear Information System (INIS)

Thick targets of several heavy lanthanide (Ho-Lu) compounds were bombarded by protons and "3He ions of 3 MeV/amu, and M_#alpha# and M_#beta# X-rays were measured with a crystal spectrometer. Ionization probabilities of the N-shell for zero impact parameter were obtained from the X-ray intensity ratio for proton and "3He ion impacts. A shell dependence of the ionization probability was found in a scaling plot. X-ray spectra of lanthanide compounds were compared and no chemical effect was observed. This result is considered to be due to the fact that the main component of M_#alpha# and M_#beta# lines is for radiative transition after the refilling of the 4f orbit (3d"-"14f"n"+"1 #-># 4f"n) where n denotes the number of 4f electrons of the target atom before ionization. (orig.).

1987-12-01

65

Calorimetric sensors for energy deposition measurements  

Energy Technology Data Exchange (ETDEWEB)

A calorimetric sensor with several novel design features has been developed. These sensors will provide an accurate sampling of thermal power density and energy deposition from proton beams incident on target components of accelerator-based systems, such as the Accelerator Production of Tritium Project (APT) and the Spallation Neutron Source (SNS). A small, solid slug (volume = 0.347 cc) of target material is suspended by kevlar fibers and surrounded by an adiabatic enclosure in an insulating vacuum canister of stainless steel construction. The slug is in thermal contact with a low-mass, calibrated, 100-k{Omega} thermistor. Power deposition caused by the passage of radiation through the slug is calculated from the rate of temperature rise of the slug. The authors have chosen slugs composed of Pb, Al, and LiAl.

1998-12-31

66

Adaptive Radiation Therapy for Localized Mesothelioma with Mediastinal Metastasis Using Helical Tomotherapy  

British Library Electronic Table of Contents (United Kingdom)

The purpose of this study was to compare 2 adaptive radiotherapy strategies with helical tomotherapy. A patient having mesothelioma with mediastinal nodes was treated using helical tomotherapy with pretreatment megavoltage CT (MVCT) imaging. Gross tumor volumes (GTVs) were outlined on every MVCT study. Two alternatives for adapting the treatment were investigated: (1) keeping the prescribed dose to the targets while reducing the dose to the OARs and (2) escalating the target dose while maintaining the original level of healthy tissue sparing. Intensity modulated radiotherapy (step-and-shoot IMRT) and 3D conformal radiotherapy (3DCRT) plans for the patient were generated and compared. The primary lesion and nodal mass regressed by 16.2% and 32.5%, respectively. Adapted GTVs and reduced plan...

2009-01-01

67

Quantification of radionuclide transfer in terrestrial and freshwater environments for radiological assessments  

International Nuclear Information System (INIS)

For more than thirty years, the IAEA has published a set of documents aimed at the limitation of the radiation exposure of the population from various nuclear activities. In particular, in 1994 the IAEA published Technical Reports Series No. 364, Handbook of Parameter Values for the Prediction of Radionuclide Transfer in Temperate Environments. Over the years, it has proved to be a valuable reference for radioecologists, modellers and authorities in Member States, and has been quoted in numerous impact assessments. Technical Reports Series No. 364 was based on a review of available data up to the end of 1992. However, a number of high quality critical reviews have been produced in recent years for some of the transfer parameter values which merit consideration. Thus, it was assumed that there is sufficient new information available to warrant reconsideration of a significant proportion of the values given in Technical Reports Series No. 364 and to initiate an ...

1993-04-05

68

X-ray production with sub-picosecond laser pulses  

Energy Technology Data Exchange (ETDEWEB)

The interaction of intense, sub-picosecond laser pulses with solid targets produces intense picosecond x-ray pulses. With focused laser pulses of several 10 {sup 18} W/cm{sup 2}, He-like and H-like line radiation from targets such as aluminum and silicon has been produced. The energy conversion efficiency from the laser pulse energy to the 1--2 keV line x-rays is nearly one percent. The duration of the line x-ray radiation is of the order of ten picoseconds, although this may be an upper estimate because of the temporal resolution of the x-ray streak camera. The spatial extent of the x-ray source region is only slightly larger than the laser focal spot, or about 10 {mu}m in diameter. With these characteristics, such x-ray sources emit an intensity of nearly 10{sup 14} W/cm{sup 2}. Experiments and modeling which led to the above conclusions will be discussed.

1993-12-31

69

Interinstitutional Variations in Planning for Stereotactic Body Radiation Therapy for Lung Cancer  

British Library Electronic Table of Contents (United Kingdom)

Purpose: The aim of this study was to assess interinstitutional variations in planning for stereotactic body radiation therapy (SBRT) for lung cancer before the start of the Japan Clinical Oncology Group (JCOG) 0403 trial.Methods and Materials: Eleven institutions created virtual plans for four cases of solitary lung cancer. The created plans should satisfy the target definitions and the dose constraints for the JCOG 0403 protocol.Results: FOCUS/XiO (CMS) was used in six institutions, Eclipse (Varian) in 3, Cadplan (Varian) in one, and Pinnacle3 (Philips/ADAC) in one. Dose calculation algorithms of Clarkson with effective path length correction and superposition were used in FOCUS/XiO; pencil beam convolution with Batho power law correction was used in Eclipse and Cadplan; and collapsed co...

2007-01-01

70

Characteristics of radiation-induced neoplastic transformation in vitro  

Energy Technology Data Exchange (ETDEWEB)

Data are presented to support the hypothesis that the initial step in the morphologic transformation of irradiated rodent (BALB/3T3) cells is a frequent cellular event involving a large fraction of the irradiated population. This process appears to involve DNA damage, but not to represent a targeted mutation in specific structural gene(s). Morphologic transformation and immortalization appear to be distinct steps in the overall process of transformation. In contradistinction to rodent cells, immortalization is a very rare event in human diploid cells which is induced at extremely low frequencies. The hypothesis is presented that immortality develops among clones of cells bearing stable chromosomal rearrangements which emerge during the proliferation of a population of radiation damaged cells.

1986-01-01

71

Optimizing the radiosensitive liquid-core microcapsules for the targeting of chemotherapeutic agents  

Energy Technology Data Exchange (ETDEWEB)

Microcapsules consisting of alginate and hyaluronic acid that can be decomposed by radiation are currently under development. In this study, the composition of the microcapsule material was optimized by changing the amounts of alginate and hyaluronic acid. Solutions of 0.025%, 0.05%, 0.1%, 0.2%, or 0.4% (wt./vol.) hyaluronic acid were mixed into a 0.2% alginate solution. To these mixtures, carboplatin (0.2 mmol) was added and the resulting material was used for the capsule preparation. The capsules were prepared by spraying the material into a CaCl{sub 2} solution (0.34 mol/l) using a microatomizer. These capsules were irradiated by a single dose of 2, 5, or 10 Gy {sup 60}Co {gamma}-ray radiation. Immediately after irradiation, the releasing of core content of microcapsule was determined, using a micro particle induced X-ray emission (PIXE) camera. The average diameter of the microcapsules was 22.3 {+-} 3.3 {mu}m, and that of the liquid core ...

2007-07-15

72

Interinstitutional Variations in Planning for Stereotactic Body Radiation Therapy for Lung Cancer  

International Nuclear Information System (INIS)

Purpose: The aim of this study was to assess interinstitutional variations in planning for stereotactic body radiation therapy (SBRT) for lung cancer before the start of the Japan Clinical Oncology Group (JCOG) 0403 trial. Methods and Materials: Eleven institutions created virtual plans for four cases of solitary lung cancer. The created plans should satisfy the target definitions and the dose constraints for the JCOG 0403 protocol. Results: FOCUS/XiO (CMS) was used in six institutions, Eclipse (Varian) in 3, Cadplan (Varian) in one, and Pinnacle3 (Philips/ADAC) in one. Dose calculation algorithms of Clarkson with effective path length correction and superposition were used in FOCUS/XiO; pencil beam convolution with Batho power law correction was used in Eclipse and Cadplan; and collapsed cone convolution superposition was used in Pinnacle3. For the target volumes, the overall coefficient of variation was 16.6%, and the ...

2007-06-01

74

Constraints on target chamber first wall and target designs that will enable NIF debris shields to survive  

CERN Document Server

Constraints on target chamber first wall and target designs that will enable NIF debris shields to survive

1999-01-01

75

DNA rearrangements from #gamma#-irradiated normal human fibroblasts preferentially occur in transcribed regions of the genome  

International Nuclear Information System (INIS)

Full text: DNA rearrangement events leading to chromosomal aberrations are central to ionizing radiation-induced cell death. Although DNA double-strand breaks are probably the lesion that initiates formation of chromosomal aberrations, little is understood about the molecular mechanisms that generate and modulate DNA rearrangement. Examination of the sequences that flank sites of DNA rearrangement may provide information regarding the processes and enzymes involved in rearrangement events. Accordingly, we developed a method using inverse PCR that allows the detection and sequencing of putative radiation-induced DNA rearrangements in defined regions of the human genome. The method can detect single copies of a rearrangement event that has occurred in a particular region of the genome and, therefore, DNA rearrangement detection does not require survival and continued multiplication of the affected cell. Ionizing ...

2003-08-17

76

Reprocessing of research reactor spent nuclear fuel at the PA ''Mayak''  

International Nuclear Information System (INIS)

The first Russian reprocessing facility, known as RT-1 (located at PA-Mayak in Ural region) was started on the radiochemical plant base in 1977. Nowadays RT-1 is the sole operating reprocessing plant in Russia. The main features of RT-1 is its broad spectrum of reprocessing spent nuclear fuels (SNF). The following spent fuel types are reprocessed: -) SNF from PWR reactors (WWER-440) and FB reactor (BN-600); -) SNF of transport ship reactors; -) production reactors SNF; -) research reactor spent nuclear fuel. The world-known technological processes are used at RT-1, but there are the following distinctive features. First, the universality of the three technological lines which allows not only the reprocessing of various SNF kinds, but also to implement the combined reprocessing of some types of them. Secondly, extraction of neptunium during SNF reprocessing which is used to implement its separate storage and for radioisotope production. Thirdly, target enrichment of ...

2007-03-11

77

Reprocessing of research reactor spent nuclear fuel at the PA 'Mayak'  

Energy Technology Data Exchange (ETDEWEB)

The first Russian reprocessing facility, known as RT-1 (located at PA-Mayak in Ural region) was started on the radiochemical plant base in 1977. Nowadays RT-1 is the sole operating reprocessing plant in Russia. The main features of RT-1 is its broad spectrum of reprocessing spent nuclear fuels (SNF). The following spent fuel types are reprocessed: -) SNF from PWR reactors (WWER-440) and FB reactor (BN-600); -) SNF of transport ship reactors; -) production reactors SNF; -) research reactor spent nuclear fuel. The world-known technological processes are used at RT-1, but there are the following distinctive features. First, the universality of the three technological lines which allows not only the reprocessing of various SNF kinds, but also to implement the combined reprocessing of some types of them. Secondly, extraction of neptunium during SNF reprocessing which is used to implement its separate storage and for radioisotope production. Thirdly, target enrichment of ...

2007-07-01

78

Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function.  

Science.gov (United States)

Inhibition of the phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is an appealing method for decreasing the immunoresistance and augmenting T cell-mediated immunotherapy. A major impediment to this strategy is the impact of conventional PI3K/mTOR pathway inhibitors on T cell function. In particular, rapamycin, is a well-known immunosuppressant that can decrease the activity of the PI3K/mTOR pathway in tumor cells, but also has a profound inhibitory effect on T cells. Here we show that Honokiol, a natural dietary product isolated from an extract of seed cones from Magnolia grandiflora, can decrease PI3K/mTOR pathway-mediated immunoresistance of glioma, breast and prostate cancer cell lines, without affecting critical proinflammatory T cell functions. Specifically, we show that at doses sufficient to down-regulate levels of phospho-S6 and the negative immune regulator B7-H1 in tumor cells, Honokiol does not significantly impair T cell ...

79

Ionizing radiation target groups of band 3 inserted into egg lecithin liposomes as determined by Raman spectroscopy  

Energy Technology Data Exchange (ETDEWEB)

The purified integral membrane protein, band 3, from human erythrocytes was inserted into egg lecithin liposomes. The insertion of band 3 was determined from thermal transition data from the analysis of the C-H stretching region bands recorded at temperatures from 25 to -22[sup o]C. Raman spectra show that band 3 considerably broadens and lowers the thermal transition of egg lecithin liposomes, suggesting the insertion of band 3. The band 3-inserted liposomes were irradiated with gamma-rays (40 Gy) and the radiation target groups were determined by the analysis of the structural sensitive Raman bands in the 1600-1700 cm[sup -1] (amide I), 1200-1300 cm[sup -1] (amide III) and 550-1030 cm[sup -1] (side chain amino groups) regions. The radiation-sensitive groups as identified from Raman spectra in the region 550-1030 cm[sup -1] are tyrosines and cysteines. The radiation-induced changes in the secondary ...

1993-03-01

80

Ionizing radiation target groups of band 3 inserted into egg lecithin liposomes as determined by Raman spectroscopy  

International Nuclear Information System (INIS)

The purified integral membrane protein, band 3, from human erythrocytes was inserted into egg lecithin liposomes. The insertion of band 3 was determined from thermal transition data from the analysis of the C-H stretching region bands recorded at temperatures from 25 to -22"oC. Raman spectra show that band 3 considerably broadens and lowers the thermal transition of egg lecithin liposomes, suggesting the insertion of band 3. The band 3-inserted liposomes were irradiated with gamma-rays (40 Gy) and the radiation target groups were determined by the analysis of the structural sensitive Raman bands in the 1600-1700 cm"-"1 (amide I), 1200-1300 cm"-"1 (amide III) and 550-1030 cm"-"1 (side chain amino groups) regions. The radiation-sensitive groups as identified from Raman spectra in the region 550-1030 cm"-"1 are tyrosines and cysteines. The radiation-induced changes in the secondary structure were ...

81

A shockproof container for the transport and storage of fragile or reactive target foils  

CERN Document Server

A shockproof container for the transport and storage of fragile or reactive target foils

1971-01-01

82

Measurements of K-shell x-ray production cross sections and K to L and M-shell radiative vacancy transfer probabilities for Nd, Eu, Gd, Dy and Ho at excitation with 59.5 keV photons in an external magnetic field  

International Nuclear Information System (INIS)

The effect of the #+-# 0.75 T external magnetic field on the K_#alpha#_1, K_#alpha#_2, K_#beta#_'_1 and K_#beta#_'_2 x-ray production cross sections and radiative vacancy transfer probabilities from K-shell to L2 and L3 subshells and M-shell for ferromagnetic Nd, Gd and Dy and paramagnetic Eu and Ho have been investigated, using the 59.5 keV incident photons. K-shell fluorescence yields and K x-ray intensity ratios for these elements have been determined in the external magnetic field also. The K x-rays from different targets were detected using a high-resolution Si(Li) semiconductor detector. For B = 0, the present experimental results were compared with the experimental and theoretical data in the literature. The results show that K-shell fluorescence parameters such as photoionization cross section, fluorescence yield, radiation rates, vacancy transfer probabilities and spectral linewidth can change owing to the applied ...

2006-06-19

83

Intensity-Modulated Radiation Therapy with Noncoplanar Beams for Treatment of Prostate Cancer in Patients with Bilateral Hip Prosthesis-A Case Study  

International Nuclear Information System (INIS)

Megavoltage photon intensity-modulated radiation therapy (IMRT) is typically used in the treatment of prostate cancer at our institution. Approximately 1% to 2% of patients with prostate cancer have hip prostheses. The presence of the prosthesis usually complicates the planning process because of dose perturbation around the prosthesis, radiation attenuation through the prosthesis, and the introduction of computed tomography artifacts in the planning volume. In addition, hip prostheses are typically made of materials of high atomic number, which add uncertainty to the dosimetry of the prostate and critical organs in the planning volume. When the prosthesis is bilateral, treatment planning is further complicated because only a limited number of beam angles can be used to avoid the prostheses. In this case study, we will report the observed advantages of using noncoplanar beams in the delivery of IMRT to a prostate cancer patient with bilateral ...

2010-01-01

84

Production of high-q ions by laser bombardment method  

International Nuclear Information System (INIS)

The expanding plasma produced when an intense pulse of laser radiation is focused in vacuum onto a solid target has been used as a source of highly stripped ions for collision cross-section measurements. Usable fluxes of carbon nuclei at energies of a few hundred eV/charge have been obtained by irradiation of graphite with pulses of CO"2 laser radiation at a focused power density of 3 x 10_1_0 W/cm_2. Bombardment of aluminum and iron targets at comparable power levels have yielded ions of maximum charges of 9 and 16 respectively. A time-of-flight apparatus has been constructed to utilize the laser source for measurement of electron capture cross sections for highly stripped ions in gases at energies in the few hundred eV/charge range. Apertures collimate an ion beam from the plasma blowoff, and an electrostatic analyzer selects ions from the expanding plasma which have the same energy per charge. The ...

1981-01-01

85

Beta-delayed proton emission: a new series of precursors, and the measurement of 10"-"1"6 s nuclear lifetimes  

International Nuclear Information System (INIS)

The results of investigation into a new series of Z-even nuclei - precursors of delayed protons (PDP) -"6"5Ge, "8"9Se, "9"3Kr, "8"1Zr, and "8"5Mo are presented. PDP were obtained by irradiation of targets in the following reactions: Zn(He, 2n) "6"5Ge, 22 MeV; "4"0Ca("3"2S, 2 pn) "1"9Se, 100 MeV; "6"0Ni ("1"60, 3 n), "7"3Kr, 75 MeV; "5"2Cr ("3"2S, 3n)"8"1Zr, 110 MeV; "5"6Fe("3"2S, 3n)"8"5Mo, 120 MeV. The targets (self-sustaining foils of thickness approximately 1.2 mg/cm"2) were placed at an angle of 15 deg to the direction of the ion beam. Upon irradiation targets were moved downwards into a measuring position. The spectra of protons, X and gamma-rays, and also the spectra of p - x, p-#gamma#, x - #gamma# coincidences accompanying the decay of "6"5Ge, "6"9Se,"7"3Kr and "8"1Zr, and "8"5Mo were measured. The measured half-lives are equal, to 31.5+-1.9, 27.3+-0.5, 28.5+-1.1, 6.3+-0.5, and 5.6 +-0.9 s respectively. The ...

86

Simulation for position determination of distal and proximal edges for SOBP irradiation in hadron therapy by using the maximum likelihood estimation method  

Energy Technology Data Exchange (ETDEWEB)

In radiation therapy with hadron beams, conformal irradiation to a tumour can be achieved by using the properties of incident ions such as the high dose concentration around the Bragg peak. For the effective utilization of such properties, it is necessary to evaluate the volume irradiated with hadron beams and the deposited dose distribution in a patient's body. Several methods have been proposed for this purpose, one of which uses the positron emitters generated through fragmentation reactions between incident ions and target nuclei. In the previous paper, we showed that the maximum likelihood estimation (MLE) method could be applicable to the estimation of beam end-point from the measured positron emitting activity distribution for mono-energetic beam irradiations. In a practical treatment, a spread-out Bragg peak (SOBP) beam is used to achieve a uniform biological dose distribution in the whole target volume. ...

2005-12-21

87

Role of Fusion Energy in a Sustainable Global Energy Strategy  

Energy Technology Data Exchange (ETDEWEB)

Fusion energy is one of only a few truly long-term energy options. Since its inception in the 1950s, the vision of the fusion energy research program has been to develop a viable means of harnessing the virtually unlimited energy stored in the nuclei of light atoms--the primary fuel deuterium is present as one part in 6,500 of all hydrogen. This vision grew out of the recognition that the immense power radiated by the sun is fueled by nuclear fusion in its hot core. Such high temperatures are a prerequisite for driving significant fusion reactions. The fascinating fourth state of matter at high temperatures is known as plasma. It is only in this fourth state of matter that the nuclei of two light atoms can fuse, releasing the excess energy that was needed to separately bind each of the original two nuclei. Because the nuclei of atoms carry a net positive electric charge, they repel each other. Hydrogenic nuclei, such as deuterium and tritium, must be heated to ...

2001-03-07

88

Quantitative monitoring of the fluorination process by neutron counting  

Energy Technology Data Exchange (ETDEWEB)

Plutonium metal is produced by reducing PuF{sub 4} prepared from PuO{sub 2} by fluorination. Both fluorination and reduction are batch processes at the Los Alamos Plutonium Facility. The conversion of plutonium oxide to fluoride greatly increases the neutron yield, a result of the high cross section for alpha-neutron ({alpha},n) reactions on fluorine targets compared to the (more than 100 times) smaller {alpha},n yield on oxygen targets. Because of the increase, total neutron counting can be used to monitor the conversion process. This monitoring ability can lead to an improved metal product, reduced scrap for recycle, waste reduction, minimized reagent usage, and reduce personnel radiation exposures. A new stirred-bed fluorination process has been developed simultaneously with a recent evaluation of an automated neutron-counting instrument for quantitative process monitoring. Neutrons are counted with ...

1993-12-31

89

Preliminary conceptual design of Siriu, A symmetric illumination, direct drive laser fusion reactor. Final report August 8, 1983-June 1, 1984  

International Nuclear Information System (INIS)

A critical issues study of a symmetric illumination, direct drive laser fusion reactor called SIRIUS has been conducted. In particular, the uniformity requirements for direct drive targets have been assessed and it is shown that respectable gains (more than 60) could be obtained at modest (2MJ) KrF laser energies. Previous ICF cavity designs have been examined for use in a symmetric illumination geometry and features from several designs have been combined into a dry wall cavity design with a radius of 8 meters. Neutronic and photonic analysis shows that the present SIRIUS cavity design can breed sufficient tritium (breeding ratio = 1.17) even with 32 laser ports penetrating the cavity. However, it was found that there are a few critical issues that remain to be solved before a self-consistent reactor design could be initiated. Radiation damage to final optics, thermal performance of SiC tiles on the SIRIUS cavity wall, and performance of ...

1984-01-01

90

Modeling of Fission Neutrons as a Signature for Detection of Highly Enriched Uranium  

Energy Technology Data Exchange (ETDEWEB)

We present the results of modeling intended to evaluate the feasibility of using neutrons from induced fission in highly enriched uranium (HEU) as a means of detecting clandestine HEU, even when it is embedded in absorbing surroundings, such as commercial cargo. We characterized radiation from induced fission in HEU, which consisted of delayed neutrons at all energies and prompt neutrons at energies above a threshold. We found that for the candidate detector and for the conditions we considered, a distinctive HEU signature should be detectable, given sufficient detector size, and should be robust over a range of cargo content. In the modeled scenario, an intense neutron source was used to induce fissions in a spherical shell of HEU. To absorb, scatter, and moderate the neutrons, we place one layer of simulated cargo between the source and target and an identical layer between the target and detector. The resulting neutrons ...

2004-03-09

91

Ion-induced M X-ray emission from heavy lanthanides  

Energy Technology Data Exchange (ETDEWEB)

Thick targets of several heavy lanthanide (Ho-Lu) compounds were bombarded by protons and /sup 3/He ions of 3 MeV/amu, and M/sub ..cap alpha../ and M/sub ..beta../ X-rays were measured with a crystal spectrometer. Ionization probabilities of the N-shell for zero impact parameter were obtained from the X-ray intensity ratio for proton and /sup 3/He ion impacts. A shell dependence of the ionization probability was found in a scaling plot. X-ray spectra of lanthanide compounds were compared and no chemical effect was observed. This result is considered to be due to the fact that the main component of M/sub ..cap alpha../ and M/sub ..beta../ lines is for radiative transition after the refilling of the 4f orbit (3d/sup -1/4f/sup n+1/ -> 4f/sup n/) where n denotes the number of 4f electrons of the target atom before ionization.

1987-12-01

92

Hardness and defect structures in EC316LN austenitic alloy irradiated under a simulated spallation neutron source environment using triple ion-beams  

Energy Technology Data Exchange (ETDEWEB)

For an assessment of the future US spallation neutron source (SNS) target performance, radiation induced hardening and microstructural evolution were investigated as a function of ion dose for EC316LN stainless steel. Irradiation was carried out using 3.5 MeV Fe{sup +}, 360 keV He{sup +}, and 180 keV H{sup +} simultaneous ion-beams at 200 deg. C to simulate the damage, He and H production in the SNS target vessel wall. At low dose (< 1 dpa), the predominant defects were black dots whose number density saturated rapidly within a few dpa. This was followed by the evolution of interstitial loops whose number density saturated below 15 dpa. Although He-bubbles were not visible, severely scalloped loops suggested that the implanted He/H atoms existed in the form of small clusters. Comparison with reported neutron irradiation data showed that hardening and ductility loss occurred mostly in the black dot regime (< 1 ...

2000-04-01

93

Hardness and defect structures in EC316LN austenitic alloy irradiated under a simulated spallation neutron source environment using triple ion-beams  

International Nuclear Information System (INIS)

For an assessment of the future US spallation neutron source (SNS) target performance, radiation induced hardening and microstructural evolution were investigated as a function of ion dose for EC316LN stainless steel. Irradiation was carried out using 3.5 MeV Fe"+, 360 keV He"+, and 180 keV H"+ simultaneous ion-beams at 200 deg. C to simulate the damage, He and H production in the SNS target vessel wall. At low dose (< 1 dpa), the predominant defects were black dots whose number density saturated rapidly within a few dpa. This was followed by the evolution of interstitial loops whose number density saturated below 15 dpa. Although He-bubbles were not visible, severely scalloped loops suggested that the implanted He/H atoms existed in the form of small clusters. Comparison with reported neutron irradiation data showed that hardening and ductility loss occurred mostly in the black dot regime (< 1 dpa), but that good ...

2000-04-01

94

An off-axis Cassegrain optimal design for short focal length parabolic solar concentrators  

Energy Technology Data Exchange (ETDEWEB)

The present work addresses an off-axis Cassegrain optical concentration system. The specific primary collector analyzed, a short focal length parabolic concentrator, is at the University of Florida`s Energy Park. A secondary hyperbolic reflective element was designed to redirect the solar radiation from the primary focal plane to an off-axis target on the polar axis of the primary concentrator. This ground level target will be required for planned experimental work. The analysis was performed using a numerical ray tracing procedure that incorporates both random and systematic errors due to slope and surface irregularities. The optimization process varied secondary element size, curvature, and offset angle, and yielded information required for optimum design. As a single secondary element was found impractical, three elements were designed for use at various time of the year. The numerical analysis predicts that typically 70 ...

1995-02-01

95

Functional and physical molecular size of the chicken hepatic lectin determined by radiation inactivation and sedimentation equilibrium analysis  

Energy Technology Data Exchange (ETDEWEB)

Radiation inactivation and sedimentation equilibrium analysis were used to determine the functional and physical size of the chicken hepatic membrane receptor that binds N-acetylglucosamine-terminated glycoproteins. Purified plasma membranes from chicken liver were irradiated with high energy electrons and assayed for 125I-agalactoorosomucoid binding. Increasing the dose of ionizing radiation resulted in a monoexponential decay in binding activity due to a progressive loss of binding sites. The molecular mass of the chicken lectin, determined in situ by target analysis, was 69,000 +/- 9,000 Da. When the same irradiated membranes were solubilized in Brij 58 and assayed, the binding protein exhibited a target size of 62,000 +/- 4,000 Da; in Triton X-100, the functional size of the receptor was 85,000 +/- 10,000 Da. Sedimentation equilibrium measurements of the purified binding protein yielded a lower ...

1990-03-05

96

Preparation and dosimetry of radiotherapeutic particles for arthropaties; Preparacion y dosimetria de particulas radioterapeuticas para artropatias  

Energy Technology Data Exchange (ETDEWEB)

It was developed a new formulation of macro aggregates of Samarium 153 ({sup 153} Sm-MH) for the arthropaties treatment. The radio pharmaceutic was prepared by reaction of Samarium 153 chloride (SmCl{sub 3}) in aqueous environment with sodium boron hydride in NaOH 0.5 N. The microscopic analysis shown that the particles have an average size of 4% m (range 1-14 {mu} m). The velocity of sedimentation was 0.008 cm/min with high stability in vitro in human serum. The biological studies in healthy rabbits, shown that the complex is retained inside the articulation still eight days after of the administration of the radiopharmaceutical. Likewise, it is presented the data of absorbed dose in the different target organs, which was determined by thermoluminescent dosimetry (TLD) through the use of a REMCAL phantom (radiation equivalent manikin calibration). (Author)

1999-07-01

97

Measurement of induced radioactivity in materials found around a neutron generator  

Science.gov (United States)

The induced radioactivity in the construction materials of a Cockcroft-- Walton type neutron generator was measured. Major activation products (/sup 24/ Na, /sup 28/Al, /sup 56/Mn, /sup 64/Cu, /sup 65/Ni, /sup 69m/Zn, /sup 88/Rb /sup 91/Sr /sup 101/Mo, /sup 187/W/ and resulting doses are tabulated. Results show that the highest gamma activities would be observed in the fluorescent bulbs, copper pipe, aluminum lattice rod, and the aluminum pipe clamp. Thermoluminescent dosimeter readings yield the highest doses for the copper pipe tee, copper pipe, and aluminum lattice rod. Results of measuremerts of the neutron and gamma dose profiles of the facility are shown. However the indication is clearly that the tritium target, compared to other components, is the major source of radiation both during and after shutdown. (UK)

1974-01-01

98

Highly excited spin-1 states in "8"8Sr by the (#gamma#,#gamma#) reaction  

International Nuclear Information System (INIS)

The resonant scattering of bremsstrahlung #gamma#-rays by a SrCO_3 target has been studied for #gamma#-ray energies of 5-11 MeV. Six #gamma#-transitions of energies between 6-8 MeV, which indicate six resonant states in "8"8Sr, were observed. The relative intensities of the resonantly scattered #gamma#-rays at 125 and 150"0 were found to be compatible only with the assignment of spin 1 to the six states. Radiative widths of the resonant states were deduced. The possibility that these states are components of the giant M1 resonance in "8"8Sr is discussed. (orig.).

99

Genes involved in immortalization of human mammary cells  

Energy Technology Data Exchange (ETDEWEB)

Breast cancer progression is characterized by inappropriate cell growth. Normal cells cease growth after a limited number of cell divisions--a process called cellular senescence-while tumor cells may acquire the ability to proliferate indefinitely (immortality). Inappropriate expression of specific oncogenes in a key cellular signaling pathway (Ras, Raf) can promote tumorigenicity in immortal cells, while causing finite lifespan cells to undergo a rapid senescence-like arrest. We have studied when in the course of transformation of cultured human mammary epithelial cells (HMEC), the response to overexpressed oncogenic Raf changes from being tumor-suppressive to tumor enhancing, and what are the molecular underpinnings of this response. Our data indicate: (1) HMEC acquire the ability to maintain growth in the presence of oncogenic Raf not simply as a consequence of overcoming senescence, but as a result of a newly discovered step in the process of immortal ...

2001-09-27

100

Production of rare earth enriched isotopes and americium 242 using metallphthalocyanines  

International Nuclear Information System (INIS)

A technique of producing radioactive isotopes of rare earth elements (r.e.e.) and carrier free "2"4"2Am is suggested. The technique makes use of ''sandwich'' phthalocya=- nine complexes of r.e.e. and americium placed on sorbent. This is a new type of r.e.e. compounds and actinides (C_3_2H_1_6N_8)_2M (M is a metal ion) which are thermally, radiationally and chemically stable, dissolve well in some organic solvents and do not dissolve in water. Radiation and chemically stable activated carbon is used as a sorbent carrier. After irradiation the target is treated by a weakly acid solution or complex-former solution. Radioactive atoms formed due to (n, #gamma#)-reaction and desoleting the complex because of recoil transfer into the solution. When irradiating in the flux of 10"1"3 neutr./cm"2 x s for 1 hour it is possible to produce radioactive isotopes with the yield from 20 to 90%, for example "1"6"0Tb, "1"6"6Ho with enrichment ...

101

Modelling fragmentations of amino-acids after resonant electron attachment: quantum evidence of possible direct -OH detachment  

International Nuclear Information System (INIS)

We investigate some aspects of the radiation damage mechanisms in biomolecules, focusing on the modelling of resonant fragmentation caused by the attachment of low-energy electrons (LEEs) initially ejected by biological tissues when exposed to ionizing radiation. Scattering equations are formulated within a symmetry-adapted, single-center expansion of both continuum and bound electrons, and the interaction forces are obtained from a combination of ab initio calculations and a nonempirical model of exchange and correlation effects developed in our group. We present total elastic scattering cross-sections and resonance features obtained for the equilibrium geometries of glycine, alanine, proline and valine. Our results at those geometries of the target molecules are briefly shown to qualitatively explain some of the fragmentation patterns obtained in experiments. We further carry out a one-dimensional (1D) modeling for the ...

2010-10-01

102

Measuring instrument for radiometric monitoring of solids and heavy metals in water  

International Nuclear Information System (INIS)

A combination of measuring instruments, consisting of a Beta-Sedimeter and a radionuclide X-ray fluorescence instrument, is described. With the Beta-Sedimeter the C-14-radiation is measured. Through direct irradiation with photons of a Pu238-source in an ancillary irradiation chamber and energy dispersing measurement of the K- and L-radiation resp. of the excited heavy metals with the aid of a Si(Li)-semiconductor detector and a 4-channel analyzer the heavy metal concentrations of the heavy metals Zn, Cr, Ni and Pb are determined. For the determination of cadmium the indirect excitation with Am-241 and Dy-targets is described. The system produces records and operates fully automatically in a step-by-step mode with a testing cycle of 45 minutes. In connection with the process monitoring of the wastewater from a zinc plating plant during a period of 8 months the concentration of the solid material and of the metals Cr and Zn, ...

1979-01-01

103

Measurement of L X-ray fluorescence cross-sections for elements with 45 Z50 using synchrotron radiation at 8keV  

British Library Electronic Table of Contents (United Kingdom)

The L shell fluorescence cross-sections of the elements in range 45Z50 have been determined at 8keV using Synchrotron radiation. The individual L X-ray photons, Ll, La, LbI, LbII, LgI and LgII produced in the target were measured with high resolution Si(Li) detector. The experimental set-up provided a low background by using linearly polarized monoenergetic photon beam, improving the signal-to-noise ratio. The experimental cross-sections obtained in this work were compared with available experimental data from Scofield [1,2] Krause [3,4] and Scofield and Puri et al. [5,6]. These experimental values closely agree with the theoretical values calculated using Scofield and Krause data, except for the case of Lg, where values measured of this work are slighter higher.

2011-01-01

104

Laser eye protection. Interim report, July 1989-January 1990  

Energy Technology Data Exchange (ETDEWEB)

Laser applications have proliferated in recent years and, as to be expected, their presence is no longer confined to the laboratory or places where access to their radiation can be easily controlled. One obvious application where this is so is in military operations where various devices such as laser range finders, target designators, and secure communications equipment elevate the risk of exposure, specifically eye exposure, to unacceptable levels. Although the need for eye protection in the laboratory and other controlled areas has been appreciated since the invention of the laser, the use of lasers in circumstances where safety or the risk of temporary loss of vision, which can not always be ensured by administrative procedures, has made adequate eye protection essential. It is the critical nature of many military operations that has driven the search for eye protection against both nuclear and laser radiation. At the ...

1990-01-01

105

Advances in beam physics and technology: Colliders of the future  

International Nuclear Information System (INIS)

Beams may be viewed as directed and focussed flow of energy and information, carried by particles and electromagnetic radiation fields (ie, photons). Often, they interact with each other (eg, in high energy colliders) or with other forms of matter (eg, in fixed targets, sychrotron radiation, neutron scattering, laser chemistry/physics, medical therapy, etc.). The whole art and science of beams revolve around the fundamental quest for, and ultimate implementation of, mechanisms of production, storage, control and observation of beams -- always directed towards studies of the basic structures and processes of the natural world and various practical applications. Tremendous progress has been made in all aspects of beam physics and technology in the last decades -- nonlinear dynamics, superconducting magnets and rf cavities, beam instrumentation and control, novel concepts and collider praradigms, to name a few. We illustrate ...

1994-11-14

106

Some comments on BEIR III  

International Nuclear Information System (INIS)

... organizations irradiation radiation doses radiation effects RADIATIONS.

1982-01-01

107

Radiation technology of wood-plastic composite materials  

International Nuclear Information System (INIS)

... radiation effects RADIATIONS. WOOD-PLASTIC COMPOSITES.

1981-10-02

108
110
112

Computational Challenges in miRNA Target Predictions: To Be or Not to Be a True Target?  

UK PubMed Central (United Kingdom)

All microRNA (miRNA) target—finder algorithms return lists of candidate target genes. How valid is that output in a biological setting? Transcriptome analysis has proven to be a useful approach...Full Text Available

2009-01-01

113
114

Chamber technology concepts for inertial fusion energy: Three recent examples  

Energy Technology Data Exchange (ETDEWEB)

The most serious challenges in the design of chambers for inertial fusion energy (IFE) are 1) protecting the first wall from fusion energy pulses on the order of several hundred megajoules released in the form of x rays, target debris, and high energy neutrons, and 2) operating the chamber at a pulse repetition rate of 5-10 Hz (i.e., re-establishing, the wall protection and chamber conditions needed for beam propagation to the target between pulses). In meeting these challenges, designers have capitalized on the ability to separate the fusion burn physics from the geometry and environment of the fusion chamber. Most recent conceptual designs use gases or flowing liquids inside the chamber. Thin liquid layers of molten salt or metal and low pressure, high-Z gases can protect the first wall from x rays and target debris, while thick liquid layers have the added benefit of protecting structures from fusion neutrons thereby ...

1997-02-27

115

Molecular targeted treatment and radiation therapy for rectal cancer  

Energy Technology Data Exchange (ETDEWEB)

Background: EGFR (epidermal growth factor receptor) and VEGF (vascular endothelial growth factor) inhibitors confer clinical benefit in metastatic colorectal cancer when combined with chemotherapy. An emerging strategy to improve outcomes in rectal cancer is to integrate biologically active, targeted agents as triple therapy into chemoradiation protocols. Material and methods: cetuximab and bevacizumab have now been incorporated into phase I-II studies of preoperative chemoradiation therapy (CRT) for rectal cancer. The rationale of these combinations, early efficacy and toxicity data, and possible molecular predictors for tumor response are reviewed. Computerized bibliographic searches of Pubmed were supplemented with hand searches of reference lists and abstracts of ASCO and ASTRO meetings. Results: the combination of cetuximab and CRT can be safely applied without dose compromises of the respective treatment components. Disappointingly low rates of pathologic ...

2009-06-15

116

Underground cable: Best for cogeneration links  

Energy Technology Data Exchange (ETDEWEB)

This article addresses the connection of cogeneration plants to the utility system. The article provides examples for use in illustrating the problems that must be overcome and the solution chosen. These illustrations include high voltage utility connection, multiple connections to the utility at one location, and dealing with losses and obstructions.

1989-05-01

117

Transarterial injection of H101 in combination with chemoembolization overcomes recurrent hepatocellular carcinoma  

UK PubMed Central (United Kingdom)

Transcatheter arterial chemoembolization (TACE) has become the standard treatment modality for unresectable hepatocellular carcinoma (HCC). Nonetheless, the clinical outcomes in patients with unresectable...Full Text Available

2011-05-14

118

The phase space of tachyons  

International Nuclear Information System (INIS)

The phase space of quantized systems that contain tachyons has been investigated. Interpretation difficulties and unexpected divergences are found when it is considered the volume of Lorentz-invariant phase space. These problems can be overcome, however, at the expense of Lorentz invariance.

119

The human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces  

UK PubMed Central (United Kingdom)

Peripheral subunit binding domains (PSBDs) are integral parts of large multienzyme complexes involved in carbohydrate metabolism. PSBDs facilitate shuttling of prosthetic groups between different catalytic...Full Text Available

2010-09-01

120

The high Andes, gene flow and a stable hybrid zone shape the genetic structure of a wide-ranging South American parrot  

UK PubMed Central (United Kingdom)

BackgroundWhile the gene flow in some organisms is strongly affected by physical barriers and geographical distance, other highly mobile species are able to overcome such constraints....Full Text Available

121

The future of dentistry: new challenges, new directions.  

UK PubMed Central (United Kingdom)

The challenge to our profession today is to improve the quality of oral health while overcoming both extrinsic and intrinsic factors which may adversely affect our progress toward this goal. The combined...Full Text Available

1990-05-01

122

Phase space of tachyons  

Energy Technology Data Exchange (ETDEWEB)

The phase space of quantized systems that contain tachyons has been investigated. Interpretation difficulties and unexpected divergences are found when we consider the volume of Lorentz-invariant phase space. These problems can be overcome, however, at the expense of Lorentz invariance.

1983-12-21

123

PREVENTING TOBACCO USE AMONG YOUNG PEOPLE  

UK PubMed Central (United Kingdom)

Preventing tobacco use in youths may be an easier task than helping adults break the habit of smoking and overcome its ill effects. Using experimental procedures based on social work techniques,...Full Text Available

1986-01-01

124

PRELIMINARY STUDY ON MODIFICATION OF YOLK SAC OF ZEBRAFISH EMBRYOS (DANIO RERIO) USING MICROINJECTION  

UK PubMed Central (United Kingdom)

Low membrane permeability is one of the major obstacles to the successful cryopreservation of zebrafish embryos. The aim of the present study was to explore if this could be overcome by yolk...Full Text Available

2006-01-01

125

PLESIOTHERAPY FOR NON-MELANOMA SKIN CANCER: INNOVATING TO OVERCOME!  

UK PubMed Central (United Kingdom)

Background:The non-surgical management of non-melanoma skin cancers is an area requiring clinical investigation. Radiotherapy has a role in treatment for a defined subset...Full Text Available

2010-10-01

126

Overcoming the challenges of membrane protein crystallography  

UK PubMed Central (United Kingdom)

Membrane protein structural biology is still a largely unconquered area, given that approximately 25% of all proteins are membrane proteins and yet less than 150 unique structures are available. Membrane...Full Text Available

2008-10-01

127

Nitrogen limitation and nitrogen fixation during alkane biodegradation in a sandy soil.  

UK PubMed Central (United Kingdom)

We investigated nutrient limitations during hydrocarbon degradation in a sandy soil and found that fixed nitrogen was initially a limiting nutrient but that N limitation could sometimes be overcome...Full Text Available

1993-09-01

128

Long-lived states to sustain hyperpolarized magnetization  

UK PubMed Central (United Kingdom)

Major breakthroughs have recently been reported that can help overcome two inherent drawbacks of NMR: the lack of sensitivity and the limited memory of longitudinal magnetization. Dynamic nuclear polarization...Full Text Available

2009-11-03

129

Host plant shifts affect a major defense enzyme in Chrysomela lapponica  

UK PubMed Central (United Kingdom)

Chrysomelid leaf beetles use chemical defenses to overcome predatory attack and microbial infestation. Larvae of Chrysomela lapponica that feed on willow sequester plant-derived salicin...Full Text Available

2011-03-22

130

Investigation of respiratory-dependent movements of pulmonary space-occupying lesions with MRI; Untersuchung der atemabhaengigen Bewegungen pulmonaler Raumforderungen mit der MRT  

Energy Technology Data Exchange (ETDEWEB)

Parallel imaging and echo sharing techniques have markedly reduced the acquisition times for MRI of large volumes. Dynamic 2 and 3-dimensional data sets of the chest with high temporal resolution (up to 10 images/s with single slice and 2 volume/s) allow an analysis of respiratory motion of the lungs and tumors. Time-resolved 2D series in preselected planes can be used to observe respiratory motion during free breathing or after respiratory commands, e.g. to exclude chest wall invasion by a tumor or for diagnosing impairment of respiratory mechanics. Time-resolved 3D-series (4D-MRI) allow monitoring of the spatial displacement of the lungs and tumors as a whole volume. Present limitations such as an overestimation of tumor size and an underestimation of displacement due to a limited temporal resolution are expected to be overcome with further technical developments. However, 4D-MRI already appears to be the appropriate tool to select patients for motion-adapted ...

2009-08-15

131

CFD investigation of balcony spill plumes in atria (part II)  

Energy Technology Data Exchange (ETDEWEB)

This paper proposes an integrated method for using experimental data and CFD modeling to develop engineering correlations for atrium smoke management. Part I focused on the experimental program and validation of a CFD model of the experimental facility. Part II describes the extension of this model to a parametric study of balcony spill plumes. Smoke management in buildings during fire events often uses mechanical ventilation systems to maintain smoke layer elevation above a safe evacuation path. Design of these systems requires accurate correlations for the smoke production or mass flow rate of the buoyant fire plume. One design issue is the mass flow rate of fire plumes which spill out from a fire compartment, under a balcony and up through an atrium or other large volume. Current engineering correlations for these balcony spill plumes (BSPs) are based on a combination of one-tenth scale test data and theoretical analysis. The suitability of these correlations for real-scale designs ...

2005-07-01

132

CFD investigation of balcony spill plumes in atria (part II)  

International Nuclear Information System (INIS)

This paper proposes an integrated method for using experimental data and CFD modeling to develop engineering correlations for atrium smoke management. Part I focused on the experimental program and validation of a CFD model of the experimental facility. Part II describes the extension of this model to a parametric study of balcony spill plumes. Smoke management in buildings during fire events often uses mechanical ventilation systems to maintain smoke layer elevation above a safe evacuation path. Design of these systems requires accurate correlations for the smoke production or mass flow rate of the buoyant fire plume. One design issue is the mass flow rate of fire plumes which spill out from a fire compartment, under a balcony and up through an atrium or other large volume. Current engineering correlations for these balcony spill plumes (BSPs) are based on a combination of one-tenth scale test data and theoretical analysis. The suitability of these correlations for real-scale designs ...

133

Accuracy of two heterogeneity dose calculation algorithms for IMRT in treatment plans designed using an anthropomorphic thorax phantom  

International Nuclear Information System (INIS)

With the advent of intensity-modulated radiation therapy (IMRT), the inclusion of heterogeneity corrections is further complicated by the conformal delivery of many small beams forming steep dose gradients. Radiation treatment planning has evolved to take into account even small changes in tissue density so that the dose to tumor can be further optimized. However, different treatment planning systems incorporate different heterogeneity correction algorithms, and it is unclear whether any of these algorithms are superior to others in terms of accurately predicting delivered radiation doses relative to measurement in a clinical setting. The purpose of this study was to determine the accuracy of heterogeneity dose calculations from two widely used IMRT treatment planning systems (Pinnacle and Corvus) against measurement. These two systems handle heterogeneity dose corrections by means of a collapsed-cone convolution ...

2007-05-01

134

Triple ion-beam studies of radiation damage effects in a 316LN austenitic alloy for a high power spallation neutron source  

Energy Technology Data Exchange (ETDEWEB)

Austenitic 316LN alloy was ion-irradiated using the unique Triple Ion Beam Facility (TIF) at ORNL to investigate radiation damage effects relevant to spallation neutron sources. The TIF was used to simulate significant features of GeV proton irradiation effects in spallation neutron source target materials by producing displacement damage while simultaneously injecting helium and hydrogen at appropriately high gas/dpa ratios. Irradiations were carried out at 80, 200, and 350 C using 3.5 MeV Fe{sup ++}, 360 keV He{sup +}, and 180 keV H{sup +} to accumulate 50 dpa by Fe, 10,000 appm of He, and 50,000 appm of H. Irradiations were also carried out at 200 C in single and dual ion beam modes. The specific ion energies were chosen to maximize the damage and the gas accumulation at a depth of {approximately} 1 {micro}m. Variations in microstructure and hardness of irradiated specimens were studied using transmission electron microscopy (TEM) and a ...

1997-09-01

135

Radiosurgery for metastatic brain tumors  

International Nuclear Information System (INIS)

Stereotactic radiosurgery (SRS) precisely delivers high-dose radiation to a small target (usually less than 3-4 cm in diameter), in a single session with steep dose-fall, employing various radiation methods. SRS provides good tumor control for small brain metastases from various primary cancers, with minimal untoward effects on surrounding normal brain. This excellent tumor control prevents neurological death and maintains good activity of daily life. Although surgery with whole-brain radiation therapy (WBRT) remains an important option for patients with a solitary brain metastasis, SRS with or without WBRT should be considered in patients with a limited number of small tumors and a good prognosis. Many reports, as well as both retrospective and prospective reviews, have shown WBRT before or after SRS to improve local control and reduce new distant lesion emergence. However, upfront WBRT does not ...

2009-08-01

136

Predictive model of electron-beam-induced flashblindness. Final report, November 1983-October 1984  

Energy Technology Data Exchange (ETDEWEB)

The spectral characteristics of the Cherenkov radiation have been evaluated and converted to equivalent retinal irradiance from external sources. On the basis of the conversion, electron fluxes have been estimated for 2-sec recovery times from flashblindness. The electrons are assumed to have energies greater than 6 MeV and to be delivered in one or more bursts of 1 microsecond each over 1 sec. It is important to note that very little data exists on recovery times as short as 2 sec for either photopic and scotopic conditions. This situation is a direct result of the lack of definition of the critical tasks and their sensitivity to an interruption of background adaptation. The Cherenkov radiation produced within the eye by relativistic electrons can be compared to light from external sources by the relationships: 1 rad approx. = 4.6 scotopic td-sec and 1 rad approx. = 0.55 photopic td sec. Based on these conversion factors, the following ...

1985-03-01

137

NOx Sensor Development  

Energy Technology Data Exchange (ETDEWEB)

NO{sub x} compounds, specifically NO and NO{sub 2}, are pollutants and potent greenhouse gases. Compact and inexpensive NO{sub x} sensors are necessary in the next generation of diesel (CIDI) automobiles to meet government emission requirements and enable the more rapid introduction of more efficient, higher fuel economy CIDI vehicles. Because the need for a NO{sub x} sensor is recent and the performance requirements are extremely challenging, most are still in the development phase. Currently, there is only one type of NO{sub x} sensor that is sold commercially, and it seems unlikely to meet more stringent future emission requirements. Automotive exhaust sensor development has focused on solid-state electrochemical technology, which has proven to be robust for in-situ operation in harsh, high-temperature environments (e.g., the oxygen stoichiometric sensor). Solid-state sensors typically rely on yttria-stabilized zirconia (YSZ) as the oxygen-ion conducting electrolyte and then ...

2010-11-01

138

The Use of Medical Images in Planning and Delivery of Radiation Therapy  

UK PubMed Central (United Kingdom)

Abstract The authors provide a survey of how images are used in radiation therapy to improve the precision of radiation therapy plans, and delivery of radiation treatment. In contrast...Full Text Available

1997-09-01

140
141

Animal Models for Radiation Injury, Protection and Therapy  

Science.gov (United States)

... radiation during clinical therapy and exposures due to radiation accidents or attacks, in which the doses are uncontrolled ... only be used off-label in victims of radiation accidents or attacks. The idea...

142

Targeting Prostate Cancer Cells In Vivo Using a Rapidly Internalizing Novel Human Single-Chain Antibody Fragment  

UK PubMed Central (United Kingdom)

Human antibodies targeting prostate cancer cell surface epitopes may be useful for imaging and therapy. The objective of this study was to evaluate the tumor targeting of an internalizing human...Full Text Available

2010-03-01

144

Isoform-level microRNA-155 target prediction using RNA-seq  

UK PubMed Central (United Kingdom)

Computational prediction of microRNA targets remains a challenging problem. The existing rule-based, data-driven and expression profiling approaches to target prediction are mostly approached from the...Full Text Available

2011-05-01

145

Delineating Bacteriostatic and Bactericidal Targets in Mycobacteria Using IPTG Inducible Antisense Expression  

UK PubMed Central (United Kingdom)

In order to identify novel high value antibacterial targets it is desirable to delineate whether the inactivation of the target enzyme will lead to bacterial death or stasis. This knowledge is particularly...Full Text Available

146

The result of Alanine/ESR dosimetry at Wolsung unit 1  

International Nuclear Information System (INIS)

It needs accurate estimation of radiation level for verifying machinery and cable in Nuclear Power Plant. Therefore, in this study, we used ESR(Electron Spin Resonance) system for estimate dose of Alanine dosimeter. Alanine/ESR dosimetry, already known as a dosimetric method in medical and industrial field, was applied to estimate dose quantity at cable locations within a nuclear power plant as a part of equipment qualification program. Alanine/ESR dosimetry of absorbed dose range is 1 - 100 KGy. The alanine dosimeter is not significantly affected by temperature and fading is limited to 1% per year. The alanine dosimeters were fixed on the targeted cable or nearest position to measure dose quantity to get accurate value. Alanine dosimeters were scanned by commercially used two different ESR systems, e-scan and EMX series for alanine dosimeters. To estimate more accurate dose, two environmental correction factors, irradiation temperature and ...

2008-10-01

147

Progress at LAMPF, 1992--1993  

Energy Technology Data Exchange (ETDEWEB)

This Progress Report describes the operation of the Los Alamos Meson Physics Facility (LAMPF) and the research programs carried out there for the years 1992 and 1993. The accelerator operated for over 100 days in 1992, providing beams of H{sup +}, H{sup {minus}}, and polarized H{sup {minus}} for a rich and varied research program in nuclear physics. The accelerator had only fair beam availability in 1992 (for example, the average H{sup +} beam availability was 72%), caused largely by problems in the 201-MHz rf system. A major effort was expended to address these problems before the 1993 run. These efforts were rewarded by good beam availability in 1993 and few problems with the 201-MHz system. LAMPF operated remarkably smoothly during 1993, in the midst of a period of great uncertainty in the future of the facility and the downsizing of MP Division, which led to the loss of a large number of key people to positions elsewhere in the Laboratory. The H{sup +} intensity had to be held to ...

1994-07-25

148

Programmed improvements of the alternating gradient synchrotron complex at Brookhaven National Laboratory, Upton, New York. Environmental assessment  

Energy Technology Data Exchange (ETDEWEB)

The purpose and need for DOE to undertake the actions described in this document are to improve the efficiency of the Alternating Gradient Synchrotron (AGS) complex. Benefits would include optimization of the AGS scientific program, increased high-energy and nuclear physics experimentation, improved health and safety conditions for workers and users, reduced impact on the environment and the general public, energy conservation, decreased generation of hazardous and radioactive wastes, and completion of actions required to permit the AGS to be the injector to the Relativistic Heavy Ion Collider (RHIC)., Improved efficiency is defined as increasing the AGS`s capabilities to capture and accelerate the proton intensity transferred to the AGS from the AGS booster. Improved capture of beam intensity would reduce the beam losses which equate to lost scientific opportunity for study and increased potential for radiation doses to workers and the general public. The action ...

1994-03-01

149

Dose planning and dose delivery in radiation therapy  

International Nuclear Information System (INIS)

A method has been developed for calibration of CT-numbers to volumetric electron density distributions using tissue substitutes of known elemental composition and experimentally determined electron density. This information have been used in a dose calculation method based on photon and electron interaction processes. The method utilizes a convolution integral between the photon fluence matrix and dose distribution kernels. Inhomogeneous media are accounted for using the theorems of Fano and O'Connor for scaling dose distribution kernels in proportion to electron density. For clinical application of a calculated dose plan, a method for prediction of accelerator output have been developed. The methods gives the number of monitor units that has to be given to obtain a certain absorbed dose to a point inside an irregular, inhomogeneous object. The method for verification of dose distributions outlined in this study makes it possible to exclude the treatment related variance contributions, ...

2008-08-01

150

Actual and future strategies in interdisciplinary treatment of medulloblastomas, supratentorial PNET and intracranial germ cell tumors in childhood  

International Nuclear Information System (INIS)

Methods: Systemic irradiation of neuroaxis is an essential part in the management of medulloblastoma, stPNET and intracranial germ cell tumors. The introduction of quality assurance programs in radiooncology assures a precise radiotherapy of target volumes and is a prerequisite to improve survival. Results: Hyperfractionated radiotherapy has the potential of increasing dose to tumor more safely without increasing the risk for late adverse effects. Pilot studies revealed excellent tumor control in medulloblastoma with acceptable acute toxicity and a long-term survival of up to 96%. In medulloblastoma stereotactic radiation techniques reveal an acceptable toxicity and promising results in tumor control in recurrent disease or as primary treatment. They are now part of future treatment protocols in case of persisting residual tumor. Radiotherapy alone in pure germinoma is continuously yielding high cure rates. In secreting germ cell tumors ...

2001-09-01

151

Activation of Polymethyl-Methacrylate by Proton Beam  

International Nuclear Information System (INIS)

Activation has been used for many kinds of useful applications, such as use of the radioisotopes for diagnosis and treatment of cancer, and wear (or corrosion) investigation for using thin layer activation (TLA) technique, etc. But activation also has severe problems for the post-processing of the samples; such as time-loss, inconvenience of sample handling, personal radiation safety, etc. For in-vitro experiments, we observed death of tumor cells by proton irradiation. The use of large activated container material can cause erroneous results in this case. To solve these problems, we studied why the samples were activated and how the level of the activation could be reduced. In proton beam irradiation experiments, the target materials could be defined as the container and sample itself. We could easily reduce activation of container material comparing to activation of sample itself. Therefore, we tried to find less activated container material ...

2010-10-01

152

A new plateau in the dose-survival-time response of the golden hamster (Mesocricetus auratus) from whole body irradiation  

International Nuclear Information System (INIS)

The survival time of golden hamsters (Mesocricetus auratus) after whole-body "6"0Co-#gamma#-irradiation in the range of 600 to 200 000 rad was investigated. The two plateaus of the dose-survival curve which correspond to bone marrow and gastrointestinal death are similar to those of other species such as mice, rats and mongolian gerbils. A new plateau occurring 40-57 hours after doses of 30 000-60 000 rad, where there is a little reduction in survival time, has been found. It is in addition to the well recognized central nervous system (CNS) syndrome. This plateau is observed only in golden hamsters, presumably because of their relatively high resistance to CNS syndrome. Experiments involving partial body irradiation of the animals indicate that the target is in the cephalic one-third of abdomen. The new segment may well indicate a new type of acute somatic radiation injury different from the well known bone marrow, gastrointestinal and CNS ...

1981-01-01

153

A convolution/superposition method using primary and scatter dose kernels formed for energy bins of X-ray spectra reconstructed as a function of off-axis distance: a theoretical study on 10-MV X-ray dose calculations in thorax-like phantoms  

British Library Electronic Table of Contents (United Kingdom)

A convolution/superposition method is proposed for use with primary and scatter dose kernels formed for energy bins of X-ray spectra reconstructed as a function of off-axis distance. It should be noted that the number of energy bins is usually about ten, and that the reconstructed X-ray spectra can reasonably be applied to media with a wide range of effective Z numbers, ranging from water to lead. The study was carried out for 10-MV X-ray doses in water and thorax-like phantoms with the use of open-jaw-collimated fields. The dose calculations were made separately for primary, scatter, and electron contamination dose components, for which we used two extended radiation sources: one was on the X-ray target and the other on the flattening filter. To calculate the in-air beam intensities at po...

2011-01-01

154

A thermal hydraulic investigation on ADSR liquid lead target  

Energy Technology Data Exchange (ETDEWEB)

Computational fluid dynamics(CFD) code FLUENT was used to simulate the thermal hydraulic processes occurring in conceptual design of the accelerator-driven subcritical reactor(ADSR) liquid lead target. The purpose of the analysis is to investigate the thermal hydraulic characteristics of liquid lead as ADSR target material with various target geometries and injection locations of proton beam. In the calculation analysis, the local temperature of the liquid lead target rises to the boiling temperature very rapidly. When the proton beam is injected from the bottom of the target system, the duration time to reach the boiling temperature is longer and the temperature distribution is flatter than other cases.

1998-05-01

155

Studies of nuclear processes at the Triangle Universities Nuclear Laboratory. Progress report, 1 September 1995--31 August 1996  

Energy Technology Data Exchange (ETDEWEB)

The Triangle Universities Nuclear Laboratory (TUNL)--a collaboration of Duke University, North Carolina State University, and the University of North Carolina at Chapel Hill--has had a very productive year. This report covers parts of the second and third year of a three-year grant between the US Department of Energy and the three collaborating universities. The TUNL research program focuses on the following areas: precision test of parity-invariance violation in resonance neutron scattering at LANSCE/LANL; parity violation measurements using charged-particle resonances in A = 20--40 targets and the A = 4 system at TUNL; chaotic behavior in the nuclei {sup 30}P and {sup 34}Cl from studies of eigenvalue fluctuations in nuclear level schemes; search for anomalies in the level density (pairing phase transition) in 1f-2p shell nuclei using GEANIE at LANSCE/LANL; parity-conserving time-reversal noninvariance tests using {sup 166}Ho resonances at Geel, ORELA, or ...

1996-09-01

156

The response of small scale rigid targets to shallow buried explosive detonations  

British Library Electronic Table of Contents (United Kingdom)

Experimental and computational investigations were performed in order to better understand the mechanical response of rigid targets with various geometries to the detonation of shallow buried explosives. The motion of the targets was measured by use of high-speed digital video photography. This work involved flat targets, targets that were downwardly convex, and targets that were downwardly concave with explosive charges located at various positions beneath the targets. It was observed that, in general, angled hulls - whether downwardly concave or convex - tended to reduce the amount of momentum imparted to the center of mass of the targets. Computations were performed by use of an arbitrary Langrangian-Eulerian treatment in a nonlinear finite element code. A model based on quasi-static te...

2011-01-01

157

Targeting a Ruthenium Complex to the Nucleus with Short Peptides  

UK PubMed Central (United Kingdom)

In an effort to develop octahedral metal complexes as chemotherapeutic and diagnostic agents targeted to DNA, it is critical to optimize the properties of their cellular uptake. Appending d-octaarginine...Full Text Available

2010-05-15

158

Target stations and beam dumps for the CERN SPS  

International Nuclear Information System (INIS)

The design of the absorber blocks for internal and external dumping of the SPS proton beam is discussed. In addition, the external target stations for slow and fast extracted proton beams are described.

1977-03-16

159

Suitability of a New Plant Invader as a Target for Biological Control in Florida  

Science.gov (United States)

... L. Sutton. 2000. Is the aquatic weed hygrophila, Hygrophila polysperma (Polemoniales: Acanthaceae), a suitable target for classical biological ... ...

160

Nato SCI-12 on Camouflage Evaluation Workshop on Search and Target ...  

Science.gov (United States)

Nato SCI-12 on Camouflage Evaluation Workshop on Search and Target Acquisition The Netherlands, June 1999. Image Discrimination Models for Object Detection ...

161

FOR THIN AND THICK TARGETS - NASA Technical Report Server (NTRS)  

Science.gov (United States)

By W. Wayne Scott. Langley Research Center. SUMMARY. Thin- and thick-target bremsstrahlung spectra are presented for electron energies up to 7.0 MeV. ...

162

Sorbent extraction and high performance liquid chromatography (HPLC) of homidium bromide and isometamidium chloride in bovine plasma  

International Nuclear Information System (INIS)

Homidium bromide and isometamidium chloride are used extensively in the treatment of bovine trypanosomiasis in Africa, but no specific and sensitive method to detect the drug in plasma has been published yet. Comparing the methods of other investigators it was found that they could not overcome the protein binding of these drugs which reduced the available and determined drug to 10% of the real concentrations. These techniques overcome the protein binding by enzyme digestion and an alteration of the pH before adding the sample directly on clean-up columns. Drug recover rates above 80% were obtained. For the detection, the HPLC was employed using a C18 reversed phase analytical column and UV detection, determining both drugs as intact molecules. (author).

1992-01-01

163

Case study: Accelerated schedule for MULTI LIMS installation  

Energy Technology Data Exchange (ETDEWEB)

This presentation focuses on the steps taken by the Westinghouse Hanford Company to meet an accelerated schedule for configuration and implementation of the MULTI LIMS in a multiple laboratory environment. The Westinghouse Hanford Company purchased the MULTI LIMS Laboratory Information Management System in August, 1993. Hardware delivery began in October, 1993. Less than four months later, the initial configuration was released for use in two Westinghouse Hanford Company laboratories. Several major obstacles were overcome during implementation. These include information gathering for base table loading, user training, acceptance of the new system by users of a legacy system, and hardware configuration issues. In summary, steps needed to be taken to meet the accelerated implementation schedule of the MULTI LIMS at the Hanford Site. The obstacles faced were overcome through the in-depth knowledge and help of the vendor and the dedication and ...

1994-05-01

164

Concepts of radiotherapy treatment planning  

International Nuclear Information System (INIS)

Full text: Radiotherapy treatment planning (RTP) relies heavily on medical imaging. Until recently, the most important planning tool was the treatment simulator. The kilovoltage radiographic capabilities in a treatment simulator enabled the boundaries of treatment fields to be visualized with respect to bony anatomic landmarks. Perhaps the most important advance in treatment planning in recent years is the ability to visualize the passage of the beams with respect to a more accurate geometrical representation of the tumor and other soft tissue structures. This 'virtual simulation' uses a computer-based representation of a patient to determine the extent of the disease and the location of radiation sensitive normal tissue. Computer tomographic (CT) imaging produces a high-resolution three-dimensional representation of anatomy that can be correlated with other image sets such as magnetic resonance images (MRI) of function. Positron emission tomographic (PET) imaging ...

2000-12-01

165

Target area chamber system design for the National Ignition Facility  

International Nuclear Information System (INIS)

The National Ignition Facility (NIF) is a proposed Department of Energy facility which will contribute to the resolution of important Defense Program and inertial fusion energy issues for energy production in the future. The NIF will consist of a laser system with 192 independent beamlets transported to a target chamber. The target chamber is a multi-purpose structure that provides the interface between the target and the laser optics. The chamber must be capable of achieving moderate vacuum levels in reasonable times; it must remain dimensionally stable within micron tolerances, provide support for the optics, diagnostics, and target positioner; it must minimize the debris from the x-ray and laser light environments; and it must be capable of supporting external neutron shielding. The chamber must also be fabricated from a low neutron activation material. The fusion reaction in the ...

1994-06-19

166

Statistical cut-off criterion  

International Nuclear Information System (INIS)

... radiation effects human populations low dose irradiation neoplasms radiation

1980-01-01

167

Radiation protection and the management of radioactive waste in the oil and gas industry  

CERN Document Server

Radiation protection and the management of radioactive waste in the oil and gas industry

2003-01-01

169

Higher harmonics of spontaneous radiation of ultrarelativistic channeled particles  

International Nuclear Information System (INIS)

The case of spontaneous radiation of channeled ultrarelativistic particles is considered when the dipolarity condition is not satisfied. The change of the particle longitudinal velocity affecting the maximum radiation frequency is included. The angular and frequency characteristics of the radiation for superhigh energies are studied for the first time. It is shown that there is an optimum energy at which the radiation density is maximum. The influence of the angle at which electrons enter a crystal and of the beam divergence on the radiation is investigated. The problem of quasichanneled particle radiation and also the radiation in axis-plane transitions are considered. (author).

1980-06-01

171

Contribution to the radiation preparation of wood-plastic materials. Pt. 7  

International Nuclear Information System (INIS)

... odd nuclei organic compounds radiation effects radioisotopes synthesis

1974-01-01

172

Contribution to the radiation preparation of wood-plastic materials. Pt. 6  

International Nuclear Information System (INIS)

... compounds polymers polyolefins polyvinyls radiation effects SYNTHESIS.

1974-01-01

173

Contribution to the radiation preparation of wood-plastic materials Pt. 3  

International Nuclear Information System (INIS)

... compounds plants radiation effects radioisotopes reaction kinetics trees

1974-01-01

174

Compact Proton and Carbon Ion Synchrotrons for Radiation Therapy  

CERN Document Server

Compact Proton and Carbon Ion Synchrotrons for Radiation Therapy

2002-01-01

175

? j -  

Science.gov (United States)

duced and spontaneous radiation. The amount of polarization is ... of the induced and spontaneous radiation patterns. Therefore ...

176

Accuracy of patient dose calculation for lung IMRT: A comparison of Monte Carlo, convolution/superposition, and pencil beam computations  

International Nuclear Information System (INIS)

The accuracy of dose computation within the lungs depends strongly on the performance of the calculation algorithm in regions of electronic disequilibrium that arise near tissue inhomogeneities with large density variations. There is a lack of data evaluating the performance of highly developed analytical dose calculation algorithms compared to Monte Carlo computations in a clinical setting. We compared full Monte Carlo calculations (performed by our Monte Carlo dose engine MCDE) with two different commercial convolution/superposition (CS) implementations (Pinnacle-CS and Helax-TMS's collapsed cone model Helax-CC) and one pencil beam algorithm (Helax-TMS's pencil beam model Helax-PB) for 10 intensity modulated radiation therapy (IMRT) lung cancer patients. Treatment plans were created for two photon beam qualities (6 and 18 MV). For each dose calculation algorithm, patient, and beam quality, the following set of clinically relevant dose-volume values was reported: ...

2006-09-01

177

Triple ion-beam studies of radiation damage in 9Cr2WVTa ferritic/martensitic steel  

Energy Technology Data Exchange (ETDEWEB)

To simulate radiation damage under a future Spallation Neutron Source (SNS) environment, irradiation experiments were conducted on a candidate 9Cr-2WVTa ferritic/martensitic steel using the Triple Ion Facility (TIF) at ORNL. Irradiation was conducted in single, dual, and triple ion beam modes using 3.5 MeV Fe{sup ++}, 360 keV He{sup +}, and 180 keV H{sup +} at 80, 200, and 350{degrees}C. These irradiations produced various defects comprising black dots, dislocation loops, line dislocations, and gas bubbles, which led to hardening. The largest increase in hardness, over 63 %, was observed after 50 dpa for triple beam irradiation conditions, revealing that both He and H are augmenting the hardening. Hardness increased less than 30 % after 30 dpa at 200{degrees}C by triple beams, compatible with neutron irradiation data from previous work which showed about a 30 % increase in yield strength after 27.2 dpa at 365{degrees}C. However, the very large concentrations of gas ...

1997-11-01

178

Repeat Stereotactic Radiosurgery for Acoustic Neuromas  

International Nuclear Information System (INIS)

Purpose: To evaluate the outcome of repeat stereotactic radiosurgery (SRS) for acoustic neuromas, we assessed tumor control, clinical outcomes, and the risk of adverse radiation effects in patients whose tumors progressed after initial management. Methods and Materials: During a 21-year experience at our center, 1,352 patients underwent SRS as management for their acoustic neuromas. We retrospectively identified 6 patients who underwent SRS twice for the same tumor. The median patient age was 47 years (range, 35-71 years). All patients had imaging evidence of tumor progression despite initial SRS. One patient also had incomplete surgical resection after initial SRS. All patients were deaf at the time of the second SRS. The median radiosurgery target volume at the time of the initial SRS was 0.5 cc and was 2.1 cc at the time of the second SRS. The median margin dose at the time of the initial SRS was 13 Gy and was 11 Gy at the time of the second ...

2010-02-01

179

Radiation dosimetry of "1"1"1In-oxinate labelled leucocytes  

International Nuclear Information System (INIS)

The patients studied were referred for routine abscess localization with indium-111 labelled autologous leukocytes. One series (n=15) was studied at 1 day after reinjection of labelled cells and a second series (n=9) was studied between 4 hours and 4 days after reinjection of labelled cells. The leukocytes were isolated by a gravity sedimentation method and labelled with In-111 oxinate according to Roevekamp and co-workers. The labelled cell suspension administered to the patient contained between 11 and 15 MegaBq (300-400 microCi). The indium-111 concentration in the liver and spleen was quantitated using a scintillation camera and an on-line computer system. Phantom studies were carried out to obtain conversion factors from geometric mean counts to MegaBq of activity for both liver and spleen. Once determined, the amount of activity in liver and spleen was corrected for physical decay of In-111 and expressed as a percentage of the administered activity. Additionally in the 2nd series ...

1982-06-25

180

Construction and alignment experience of Indus-1 SRS in C.A.T  

International Nuclear Information System (INIS)

A 450 MeV Synchrotron Radiation Source, Indus-1 is being constructed at Centre for Advanced Technology at Indore in central India. This paper narrates our experience in construction and alignment of synchrotron machines which was first of its kind for most of us. Careful design, planning and execution of the work yielded modest results so that alignment accuracies between 0.1 to 0.3 mm could be achieved (in booster synchrotron) and, which have proved to be adequate up till now. The building of the SRS complex was constructed such that machine rings have their foundations isolated from rest of the building. A number of 100 x 150 mm size steel plates were embedded in the concrete of floor and walls to serve as base for reference surveying marks which were established later. The pre-injector and booster ring are enclosed in a radiation shielding zone with separate ventilation system. Dipoles, quadrupoles and a few sextupoles were fiducialised ...

1996-01-01

181

Biokinetic and dosimetric studies of {sup 188}Re-hyaluronic acid: a new radiopharmaceutical for treatment of hepatocellular carcinoma  

Energy Technology Data Exchange (ETDEWEB)

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and has very limited therapeutic options. Recently, it has been found that hyaluronic acid (HA) shows selective binding to CD44 receptors expressed in most cancer histotypes. Since the trend in cancer treatment is the use of targeted radionuclide therapy, the aim of this research was to label HA with rhenium-188 and to evaluate its potential use as a hepatocarcinoma therapeutic radiopharmaceutical. Methods: {sup 188}Re-HA was prepared by a direct labelling method to produce a ReO(O-COO){sub 2}-type coordination complex. {sup 188}Re-HA protein binding and its stability in saline, phosphate buffer, human serum and cysteine solutions were determined. Biokinetic and dosimetric data were estimated in healthy mice (n=60) using the Medical Internal Radiation Dose methodology and mouse model beta-absorbed fractions. To evaluate liver toxicity, alanine aminotranferase (AST) and ...

2009-08-15

182

Target R and D at JAERI  

Energy Technology Data Exchange (ETDEWEB)

We proposed a solid and a mercury target concepts through the preliminary conceptual design. To feasible these concepts, analysis and experimental works are being carried out. This paper introduces an outline of present status of target R and D such as heat transfer augmentation experiments for the solid target, mercury flow tests with a loop of maximum flow rate of 15L/min, flow pattern measurements for a cold source moderator etc. as well as preliminary conceptual design works. (author)

1999-03-01

187

Radiation therapy in Ewing's sarcoma: an update of the CESS 86 trial  

International Nuclear Information System (INIS)

Purpose: We present an update analysis of the multiinstitutional Ewing's sarcoma study CESS 86. Methods and Materials: From January 1986 through June 1991, 177 patients with localized Ewing's sarcoma of bone, aged 25 years or less, were recruited. Chemotherapy consisted of four 9-week courses of vincristine, actinomycin D, cyclophosphamide, and adriamycin (VACA) in low-risk tumors (extremity tumors =# 100 cm"3). Local therapy was an individual decision in each patient and was either radical surgery (amputation, wide resection) or resection plus postoperative irradiation with 45 Gy or definitive radiotherapy with 60 Gy (45 Gy plus boost). Irradiated patients were randomized concerning the type of fractionation in either conventional fractionation (once daily 1.8-2.0 Gy, break of chemotherapy) or hyperfractionated split-course irradiation simultaneously with the VACA/VAIA chemotherapy (twice daily 1.6 Gy, break of 12 days after 22.4 Gy and 44.8 Gy, total dose and treatment time as for ...

1995-07-15

188

Comparison and Physical Interpretation of MCNP and TART Neutron and Gamma Monte Carlo Shielding Calculations for a Heavy-Ion ICF System  

Energy Technology Data Exchange (ETDEWEB)

For heavy-ion beam driven inertial fusion ''liquid-protected'' reactor designs such as HYLIFE-II, a mixture of molten salts made of F{sup 10}, Li{sup -6}, Li{sup 7} and Be{sup 9} (called flibe) allows small chambers and final-focus magnets closer to the target with superconducting coils suffering higher radiation damage, though they can stand only a certain amount of energy deposited before quenching. This work has been primarily focusing on verifying that total energy deposited by fusion neutrons and induced gamma rays remain under such limit values and the final purpose is the optimization of the shielding of the magnetic lens system from the points of view of the geometrical configuration and of the physical nature of the materials adopted. The system is analyzed in terms of six geometrical models going from simplified up to much more realistic representations of a system of 192 beam lines, each focused by ...

2002-07-01

189

Clinical implementation of a convolution based algorithm for 3D treatment planning  

International Nuclear Information System (INIS)

Purpose/Objective: With the advent of computed tomography and magnetic resonance imaging, the three dimensional representation of the patient anatomy has become an invaluable resource for better diagnosis and delineation of the target volume and sensitive structures in radiation therapy. Although the therapeutic linear accelerator industry has made available highly sophisticated equipment, the aggressiveness in dose prescription and delivery has to be complimented by accurate dose computation methods. We have adopted a convolution/superposition algorithm for the calculation of absolute dose that fully accounts for the external shape and internal structure of the patient for photon treatment radiotherapy. In this paper, we will discuss the principles of the convolution algorithm and we will show how the computed dose compares to clinically relevant treatment techniques. Materials and Methods: A computer controlled data acquisition system and a ...

190

Wind tunnel modeling of heat islands in a turbulent boundary layer  

International Nuclear Information System (INIS)

The basic studies of this report, had been done with a wind tunnel. Model similarity with typical atmospheric situations - such as an urban heat island - had to exist. Sufficient heat is needed to generate turbulent convection at the ground. By omitting the Boussinesq-approximation proper similarity parameters could be found to present the results in a dimensionless form. Also the effect of a cross circulation was investigated as well as the question at which conditions the convection is no longer able to overcome the longitudinal momentum of the wind. (KW).

191

Stent-in-stent through a side hole to prevent biliary metallicstent migration  

UK PubMed Central (United Kingdom)

The covered self-expandable metallic stent (SEMS) has been developed to overcome the problem of tissue in­growth, However, stent migration is a well-known com­­plication of covered...Full Text Available

2011-03-16

192

Side chain SAR of bicyclic [beta]-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem  

Energy Technology Data Exchange (ETDEWEB)

Bridged monobactam {beta}-lactamase inhibitors were prepared and evaluated as potential partners for combination with imipenem to overcome class C {beta}-lactamase mediated resistance. The (S)-azepine analog 2 was found to be effective in both in vitro and in vivo assays and was selected for preclinical development.

2010-09-17

193

Program Status | Environmental Information Exchange Network & Grant Program | US EPA  

Wastenet

... Reduce partner costs, save time, and overcome delays in data transmission. Data Exchanges States are currently submitting data to each other and to the EPA in the exchanges listed below. Data Exchanges are typically referred to by their acronyms, which are listed below. To find out more about EPA data exchanges, please follow the links to EPA Web sites. AQS - Air Quality Sub-system (...

194

New designs for Ultra High High-Power Single Transverse Mode Cw fibre lasers  

International Nuclear Information System (INIS)

Overcoming the limiting constraints of stimulated Raman scattering (SRS) and stimulated Brilluoin scattering (SBS) poses serious fibre design challenges for increasing the output power of optical amplifiers and lasers. New fibre amplifier designs are proposed to break out of these limitations to reach several kWs CW powers. (Author)

2009-04-01

195

New applications for plasma nitriding  

International Nuclear Information System (INIS)

Low pressure plasmas have some promising advantages for nitriding The separation of plasma generation from the workpiece overcomes several of the major drawbacks of conventional plasma nitriding and also allows independent control of ion flux and energy This opens the possibility of nitriding at lower temperatures so that the process can be extended to a wider range of materials and applications. Copyright (1999) Materials Australia

1999-06-01

196

LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells  

UK PubMed Central (United Kingdom)

BackgroundAs EBV-associated gastric cancer has unique features that are different from EBV (-) gastric cancer, EBV is considered to have a key role in gastric carcinogenesis. It...Full Text Available

197

Investigation of a thermoplastic-powder metallurgy process for the fabrication of porous niobium rods  

International Nuclear Information System (INIS)

The feasibility of using a thermoplastic-powder metallurgy technique for the fabrication of porous niobium rods was investigated. Some early problems were overcome to successfully extrude the polymer coated niobium powder into long lengths. The effects of certain process variables were investigated. Residual porosity and extrusion pressure were found to be regulated by the polymer fraction. The procedures for taking the extruded polystyrene--niobium rods through the heat treatments to the final, tin infiltrated stage are explained.

1976-04-30

198

How to decorate FIB cross sections using plasma etch for SEM observation  

Energy Technology Data Exchange (ETDEWEB)

The Focused-Ion-Beam (FIB) is a powerful tool for fast, precision cross-sectioning and inspection of submicron defects in multilayered integrated circuit devices. However, the low contrast between the layers in FIB cross-sections can make the feature of interest difficult to observe, which has become a limitation for FIB cross-sectioning. A technique using plasma etch to decorate the FIB cross-sections has proven to be a simple solution to overcome this limitation.

1995-12-31

199

Design and operation of a quadruple effect evaporator with concentrator  

Energy Technology Data Exchange (ETDEWEB)

For the sugar industry, a new system of multiple-effect evaporation consuming minimal steam has been designed by means of a mathematical model and its advantages and characteristics are analysed. A way is found to overcome difficulty in operation and instability of the amount of steam consumed. Statistical data obtained using the new system are compared with the old system and show an economic profit as well as confirming the validity of the model. (author)

1993-02-01

200

Development of internal dose estimation software on radiation protection  

International Nuclear Information System (INIS)

Objective: To develop a computerized method of internal dose estimation on radiation protection. Methods: Based on MIRD mathematic model of the organs and by means of the programming language of MS Visual Basic 6.0, a computer program of dose estimation in internal radiation was developed for radiation protection. Results: The computerized method of dose estimation for internal radiation was completed. Conclusions: This computerized method is very convenient for internal radiation dose estimation of several aspects. It can also be used in radiation accident. (authors)

2008-10-01

201

The evaluation of risks from radiation  

International Nuclear Information System (INIS)

German translation of the publication 'The evaluation of risks from radiation' published in 1965 by the International Commission on Radiological Protection. In a survey, genetic and somatic risks from radiation are presented and explained. (HP).

1977-01-01

203

Role of Mast Cells in Early and Delayed Radiation Injury in Rat Intestine  

Science.gov (United States)

... mast cell staining; ref. 16). The severity of structural radiation injury was assessed using a histopathological radiation injury score ... ...

204

Radionuclide X-ray fluorescence analysis. 1: Excitation of X-ray fluorescense radiation by nuclear radiation  

Science.gov (United States)

The principles of radionuclide excitation of X-ray fluorescence radiation and its application in

1972-01-01

205

Radionuclide X-ray fluorescence analysis. 2: Detection of the X-ray fluorescence radiation excited by radionuclide radiation  

Science.gov (United States)

This investigation describes the technique for the detection of the X-ray fluorescent radiation

1972-01-01

206

Radiation protection - an overview of the concept for radiation protection at work and the concept for environmental radiation protection  

International Nuclear Information System (INIS)

This book gives an overview of the entire field of radiation protection with the subject areas radioactivity, X-rays, UV radiation, laser beams and high-frequency electromagnetic fields. It deals graphically with the most important physical notions, the incidence, origin, properties and biological effects of types of radiation, administrative and practical protection measures and the code of rules governing them. Apart from fundamentals of radiation protection the emphasis on the following: natural radiation exposure, radiation exposure to radon, disaster relief plans in the environment of nuclear plant, the precautionary radiation protection system evolved after Chernobyl, radiation exposure through UV radiation devices, radio, RF communication, radar, microwave ovens and high-voltage transmission ...

1993-01-01

207

Web-based training in radiology - student course in the Virtual University of Bavaria; Web-basiertes Training in der Radiologie - Studentenkurs in der Virtuellen Hochschule Bayern (VHB)  

Energy Technology Data Exchange (ETDEWEB)

Purpose: The nint version of the licensing regulation for medical doctors (Approbation Regulation (AR)) sets a benchmark in terms of practical experience, interdigitation of preclinical and clinical studies, interdisciplinary approach, economic efficiency, independence of students, added new teaching and learning modalities, and ongoing evaluation of the progress of the medical students. It is the aim to implement these major points of the AR in a model course for diagnostic radiology and radiation protection within the scope of the Virtual University of Bavaria and test them in practice. Materials and Methods: In cooperation with residents and board certified radiologists, students developed the virtual course 'Web-Based Training (WBT) Radiology' in diagnostic radiology and radiation protection for students in the first clinical semester. A representative target group taken from the student body was asked ...

2004-06-01

210

THE ENVIRONMENTAL MANAGEMENT AND CO-ORDINATION ACT, 1999  

Wastenet

Subject to the provisions of the Radiation Protection Act, the Authority, on the advice of ...(f) in collaboration with the Radiation Protection Board, conduct an ionising radiation monitoring programme and ...or document kept under the control of the Radiation Protection Board.

218

Application of gamma radiation  

International Nuclear Information System (INIS)

Described and discussed in this paper are radiation processes and their advantages over the conventional techniques. Radiation sterilization of medical products, food irradiation, wood plastic composites, and radiation treatment of sewage and waste waters are presented. The Philippine experience in using these technologies, its problems and barriers are also given. (ELC).

1985-12-10

222

Radiobiology  

International Nuclear Information System (INIS)

This text-book (electronic book - multi-media CD-ROM) constitutes a course-book - author's collection of lectures. It consists of 13 lectures in which the reader acquaints with the basis of radiobiology: Introduction to radiobiology; Physical fundamentals of radiobiology; Radiation of cells; Modification of radiation damage of cells; Reparation of radiation damage of cells; Radiation syndromes and their modification; Radiation injury; Radiation damage of tissues; Effect of radiation on embryo and fetus; Biological effects of incorporated radionuclides; Therapy of acute irradiation sickness; Delayed consequences of irradiation; Radiation oncology and radiotherapy. This course-book may be interesting for students, post-graduate students of chemistry, biology, physics, medicine as well as for teachers, scientific workers ...

223

Radiation Therapy in Treating Patients With Prostate Cancer  

Science.gov (United States)

Prostate Cancer; Psychosocial Effects of Cancer and Its Treatment; Radiation Toxicity; Sexual Dysfunction and Infertility

2011-09-13

225

NAME=\\  

Wastenet

... Radiation Protection Products and Equipment Find and compare a variety of radiation protection products and equipment on the world's largest environmental industry portal. View product ...

227

Standards and guidances for limiting ionizing radiation exposure  

Energy Technology Data Exchange (ETDEWEB)

This chapter is concerned with standards and guidances for limiting radiation exposures. It is divided into three sections, each of which has several parts. Section 1: Ionizing Radiation -- Standards and Guidances Applicable to the Public: Part A, Radiation Protection Standards; Part B, Environmental Radiation Standards; Part C, Exempt Levels of Radioactivity; Part D, Protective Action Guides for Accidents. Section 2: Ionizing Radiation -- Standards Applicable to the Workplace. Section 3: Medical and Other Standards.

1992-12-31

228

Radiation protection in the operating room  

International Nuclear Information System (INIS)

On the basis of legally provided area dose measurements and time records of fluoroscopic examinations during the operation, radiation doses to medical personnel and patients are evaluated. Adequate radiation protection measures and a careful behaviour in the operating room keep the radiation exposure to the personnel below the maximum permissible exposure. Taking into account the continuous personnel radiation monitoring and medical supervision, radiation hazards in the operating room can be considered low.

229

Targeted Deletion of Somatotroph Insulin-Like Growth Factor-I Signaling in a Cell-Specific Knockout Mouse Model  

UK PubMed Central (United Kingdom)

The role of IGF-I in the negative regulation of GH expression and release is demonstrated by in vitro and in vivo models; however, the targets and mechanisms of IGF-I...Full Text Available

2010-05-01

230

Specific genetic modifications of domestic animals by gene targeting and animal cloning  

UK PubMed Central (United Kingdom)

The technology of gene targeting through homologous recombination has been extremely useful for elucidating gene functions in mice. The application of this technology was thought impossible in the large...Full Text Available

231

Selective imaging of adherent targeted ultrasound contrast agents  

UK PubMed Central (United Kingdom)

The goal of ultrasonic molecular imaging is the detection of targeted contrast agents bound to receptors on endothelial cells. We propose imaging methods that can distinguish adherent microbubbles...Full Text Available

2007-04-21

232

National Newborn Screening Status Reports  

Science.gov (United States)

... detected (and reported) as a by-product of MRM screening (MS/MS) targeted by Law or Rule ... detected (and reported) as a by-product of MRM screening (MS/MS) targeted by Law or Rule ...

233

Inhibitors of RecA Activity Discovered by High-Throughput Screening: Cell-Permeable Small Molecules Attenuate the SOS Response in Escherichia coli  

UK PubMed Central (United Kingdom)

The phenomenon of antibiotic resistance has created a need for the development of novel antibiotic classes with non-classical cellular targets. Unfortunately, target-based drug discovery against...Full Text Available

2009-10-01

234

How DNA coiling enhances target localization by proteins  

UK PubMed Central (United Kingdom)

Many genetic processes depend on proteins interacting with specific sequences on DNA. Despite the large excess of nonspecific DNA in the cell, proteins can locate their targets rapidly. After initial...Full Text Available

2008-10-14

235

Evolutionary conservation of a microbody targeting signal that targets proteins to peroxisomes, glyoxysomes, and glycosomes  

UK PubMed Central (United Kingdom)

Peroxisomes, glyoxysomes, glycosomes, and hydrogenosomes have each been classified as microbodies, i.e., subcellular organelles with an electron-dense matrix that is bound by a single membrane. We investigated...Full Text Available

1991-09-01

236

Efficient use of accessibility in microRNA target prediction  

UK PubMed Central (United Kingdom)

Considering accessibility of the 3′UTR is believed to increase the precision of microRNA target predictions. We show that, contrary to common belief, ranking by the hybridization energy or by...Full Text Available

2011-01-01

237

Coordination of PAD4 and HDAC2 in the regulation of p53 target gene expression  

UK PubMed Central (United Kingdom)

Histone Arg methylation and Lys acetylation have been found to cooperatively regulate the expression of p53 target genes. Peptidylarginine deiminase 4 (PAD4) is an enzyme that citrullinates...Full Text Available

2010-05-27

238

Concurrent schedule control of human visual target fixations1  

UK PubMed Central (United Kingdom)

Operant conditioning techniques were applied to the study of how target fixations are controlled by the probability of signal occurrence. In a standard vigilance setting, gaze at three illuminable...Full Text Available

1973-11-01

239

Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II  

UK PubMed Central (United Kingdom)

Cytokinesis in animal and fungal cells utilizes a contractile actomyosin ring (AMR). However, how myosin II is targeted to the division site and promotes AMR assembly, and how the AMR coordinates with...Full Text Available

2010-12-27

240

Assessment of nodal target definition and dosimetry using three different techniques: implications for re-defining the optimal pelvic field in endometrial cancer  

UK PubMed Central (United Kingdom)

Purposes1. To determine the optimal pelvic nodal clinical target volume for post-operative treatment of endometrial cancer. 2. To compare the DVH of different treatment planning...Full Text Available

241

Three-quasiparticle states in "1"7"7Ta  

International Nuclear Information System (INIS)

... transitions lutetium 175 target mev range 10-100 multipolarity neutrons parity

242

Terrorism Knowledge Base (TKB)  

Science.gov (United States)

... they assisted in the 2000 attack on the USS Cole? ... List the types of targets that ETA has attacked. ... was at least partially responsible for the attack. ...

2008-04-01

243

Surgical Counter-Terrorism: Targeting Individuals as an ...  

Science.gov (United States)

... Tanzania, and the attack on the USS COLE. ... vis another has no bearing on the legality of the attack. If the person attacked is a combatant, the use of ...

2003-02-03

244

Single-Walled Carbon Nanotubes Targeted to the Tumor ...  

Science.gov (United States)

... 1981. Retention of diphenyls, terphenyls, phenylalkanes and fluorene on graphitized thermal carbon black. Chromatographia 14:510-514. ...

2009-09-01

245

Review of Vaccinia Virus and Baculovirus Viability Versus ...  

Science.gov (United States)

... hazards. One study targeted the effects of common household disinfectants on virus inactivation (Butcher and Ulaeto, 2005). ...

2008-03-01

246

Production of polarized negative ion beams by collisional pumping  

Energy Technology Data Exchange (ETDEWEB)

The production of polarized negative ion beams by collisional pumping is described. Collisional pumping utilizes repeated charge changing collisions in a thick electron-spin-polarized gas or vapor target to form a polarized fast atom beam. The polarized fast atom beam is then partially converted into a polarized negative ion beam in a vapor target. Analysis is presented for a hydrogen beam passing through either a thick polarized H atom target or a thick polarized alkali target. Large polarizations and large currents may be possible.

1983-01-01

247

Production of polarized negative ion beams by ''collisional pumping''  

Energy Technology Data Exchange (ETDEWEB)

The production of polarized negative ion beams by ''collisional pumping'' is described. Collisional pumping utilizes repeated charge changing collisions in a thick electron-spin-polarized gas or vapor target to form a polarized fast atom beam. The polarized fast atom beam is then partially converted into a polarized negative ion beam in a vapor target. Analysis is presented for a hydrogen beam passing through either a thick polarized H atom target or a thick polarized alkali target. Large polarizations and large currents may be possible.

1984-03-01

248
250

Pairing effect in the nucleon transfer processes in quasi-elastic heavy ion scattering  

International Nuclear Information System (INIS)

... range krypton 86 reactions molybdenum 92 target probability quasi-elastic

1987-04-14

251

Market segmentation and targeting for real time pricing  

Energy Technology Data Exchange (ETDEWEB)

While there is growing interest in Real Time Pricing as a competitive tool, its adoption to date has been constrained by wariness on the part of many utilities and many of their customers. That wariness is not misplaced, for Real Time Pricing is not for everyone. In order for both utilities and their customers to benefit, the pricing system must be properly tailored for, and offered to, the appropriate audience. This paper discusses needs for identifying targets, implications of targeting of Real Time Pricing to various types of customers, and implications for design and marketing of such pricing systems. Examples from utility experiences are provided, and recommendations are offered for development of improved targeting of Real Time Pricing.

1996-03-01

252

Fragmentation of nuclei by particles and nuclei of intermediate and high energies  

Energy Technology Data Exchange (ETDEWEB)

The present state of investigations into the fragmentation of target nuclei by particles and nuclei of intermediate and high energies is reviewed.

1983-11-01

254

Electron-Induced Luminescence and X-Ray Spectrometer (ELXS) System for Life Detection  

Science.gov (United States)

The ELXS concept is a novel, portable, micro-instrument targeted for the detection of mineralogic

2002-01-01

255

Electromagnetic excitations in nuclei: From photon scattering to photo-dissociation  

International Nuclear Information System (INIS)

... 98 target molybdenum 99 niobium 91 photoneutrons photonuclear reactions

2006-03-20

256

Effect of improved target designs on the "2"3"8Pu production at the Fast Flux Test Reactor  

International Nuclear Information System (INIS)

This paper present the results of a series of calculations made to determine the "2"3"8Pu production potential of several advanced target assembly designs in the Fast Flux Test Facility (FFTF). These calculations show that by using advanced target designs the intimately mix the "2"3"7Np target material with an yttrium hydride moderator, the FFTF has the potential of producing up to 30 kg of high-quality "2"3"8Pu per year.

1991-11-10

257

Survey of Radiation Protection Education and Training in Finland in 2003  

Energy Technology Data Exchange (ETDEWEB)

The current state and need for radiation protection training in Finland have been surveyed by the Radiation and Nuclear Safety Authority STUK. The survey sought to determine whether the current requirements for radiation protection training had been met, and to promote radiation protection training. Details of the scope and quality of present radiation protection training were requested from all educational institutes and organizations providing radiation protection training. The survey covered both basic and further training, special training of radiation safety officers, and supplementary training. The questionnaire was sent to 77 educational organization units, 66 per cent of which responded. Radiation workers and radiation safety officers were asked about radiation protection ...

2004-07-01

258

Target space duality II: applications  

Energy Technology Data Exchange (ETDEWEB)

We apply the framework developed in Target space duality I: general theory. We show that both nonabelian duality and Poisson-Lie duality are examples of the general theory. We propose how the formalism leads to a systematic study of duality by studying few scenarios that lead to open questions in the theory of Lie algebras. We present evidence that there are probably new examples of irreducible target space duality.

2000-09-25

259

Gastrin releasing peptide (GRP) receptor targeted radiopharmaceuticals: A concise update  

Energy Technology Data Exchange (ETDEWEB)

The gastrin releasing peptide (GRP) receptor is becoming an increasingly attractive target for development of new radiolabeled peptides with diagnostic and therapeutic potential. The attractiveness of the GRP receptor as a target is based upon the functional expression of GRP receptors in several tumors of neuroendocrine origin including prostate, breast, and small cell lung cancer. This concise review outlines some of the efforts currently underway to develop new GRP receptor specific radiopharmaceuticals by employing a variety of radiometal chelation systems.

2003-11-01

260

Effluent reduction using pinch technology: Targets for reduction and capital costs for mass exchange networks  

Energy Technology Data Exchange (ETDEWEB)

This paper illustrates how the techniques developed by the authors for capital cost targeting of mass exchange networks can be applied to determination of capital investment targets for reduction in effluent for existing systems involving mass exchange. The results is an impact diagram which shows the relationship between effluent reduction and capital investment, indicating a region of limiting return on investment as well as the maximum possible reduction in effluent. (au)

1999-02-01

261

Development of a new secondary beam separator and a new gas-jet target at Kyushu University  

International Nuclear Information System (INIS)

In order to facilitate observations of low energy nuclear reactions, a new type recoil mass-separator together with a new gas-jet target system is being developed at the tandem accelerator facility in Kyushu University. The expected mass-resolving power of the separator is 220 for a solid angle of 10 msr and the practical thickness of the gas-jet target will exceed 0.1 atm#centre dot#cm for the light elements of H and He. (author).

1994-06-01

262

Detection device for high explosives  

Energy Technology Data Exchange (ETDEWEB)

A portable fiber optic detector that senses the presence of specific target chemicals by electrostatically attracting the target chemical to an aromatic compound coating on an optical fiber. Attaching the target chemical to the coated fiber reduces the fluorescence so that a photon sensing detector records the reduced light level and activates an appropriate alarm or indicator.

1992-01-01

263

A Liquid Parahydrogen Target for the Measurement of a Parity-violating Gamma Asymmetry in Polarized Neutron Capture on Protons  

Energy Technology Data Exchange (ETDEWEB)

A 16 l liquid parahydrogen target has been developed for a measurement of the parity-violating {gamma}-asymmetry in the capture of polarized cold neutrons on protons in the {rvec n} + p {yields} d + {gamma} reaction by the NPDGamma collaboration. The target system was carefully designed to meet the stringent requirements on systematic effects for the experiment and also to satisfy hydrogen safety requirements. The target was designed to preserve the neutron polarization during neutron scattering on liquid hydrogen (LH{sub 2}), optimize the statistical sensitivity to the {rvec n} + p {yields} d + {gamma} reaction, minimize backgrounds coming from neutron interaction with the beam windows of the target cryostat, minimize LH{sub 2} density fluctuations which can introduce extra noise in the gamma asymmetry signal, and control systematic effects. The target incorporates two mechanical ...

2010-05-01

264

48 CFR 952.226-73 - Energy Policy Act target group certification.  

Science.gov (United States)

...2010-10-01 2010-10-01 false Energy Policy Act target group certification...Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION...Provisions and Clauses 952.226-73 Energy Policy Act target group...

2010-10-01

265

Using a photon phase-space source for convolution/superposition dose calculations in radiation therapy  

International Nuclear Information System (INIS)

For a given linac design, the dosimetric characteristics of a photon beam are determined uniquely by the energy and radial distributions of the electron beam striking the x-ray target. However, in the usual commissioning of a beam from measured data, a large number of variables can be independently tuned, making it difficult to derive a unique and self-consistent beam model. For example, the measured dosimetric penumbra in water may be attributed in various proportions to the lateral secondary electron range, the focal spot size and the transmission through the tips of a non-divergent collimator; the head-scatter component in the tails of the transverse profiles may not be easy to resolve from phantom scatter and head leakage; and the head-scatter tails corresponding to a certain extra-focal source model may not agree self-consistently with in-air output factors measured on the central axis. To reduce the number of adjustable variables in beam modelling, we replace ...

2005-09-07

266

RAAN Conference. Support of Nuclear Power. Opening talk  

International Nuclear Information System (INIS)

Nuclear power in Romania was initiated on the basis of CANDU reactor type technology, an option found to fulfill the requirements for a sustainable economic development, to support the electric energy demand of the country and to ensure the population and environment protection. The construction of the Cernavoda NPP was heavily based on the Romanian industry participation and basic and applied nuclear research national resources. The experience acquired from Cernavoda NPP Unit 1 will be fructified in the construction of Units 2-5 to be built. The Romanian Ministry of Education and Research implemented a nuclear national program for research and development taking into account the European Union requirements and recommendations, the cooperation with the IAEA - Vienna and the Romanian government policy on short and medium terms in the nuclear field. The research-development program targeted: the reactor physics and nuclear fuel management; the operation safety of ...

2002-09-06

267

Plasma dynamics in PF-1000 device under full-scale energy storage: I. Pinch dynamics, shock-wave diffraction, and inertial electrode  

International Nuclear Information System (INIS)

This paper (paper I) presents the first part of results obtained with the PF-1000 facility for the first time at its upper energy limit (?1 MJ). Special attention is paid here to plasma ('pinch') dynamics, which was investigated in relation to its electro-technical and radiation (especially neutron) characteristics with the help of a number of diagnostics, both time-integrated and with nanosecond temporal resolution. In these methods we utilized a Rogowski coil for the routine electro-technical measurements, visual multi-frame and streak cameras, soft x-ray pin-hole multi-frame cameras, PIN-diode assembly and PM tubes with scintillators for soft and hard x-rays as well as for neutron investigations together with a set of activation counters. In particular, the temporal cross correlation of different phenomena taking place during the discharge was investigated. The pinch's longevity appears to be 10-15 times larger than the ideal magnetohydrodynamic growth time ...

2007-04-07

268

Monte Carlo evaluation of the AAA treatment planning algorithm in a heterogeneous multilayer phantom and IMRT clinical treatments for an Elekta SL25 linear accelerator  

International Nuclear Information System (INIS)

The Anisotropic Analytical Algorithm (AAA) is a new pencil beam convolution/superposition algorithm proposed by Varian for photon dose calculations. The configuration of AAA depends on linear accelerator design and specifications. The purpose of this study was to investigate the accuracy of AAA for an Elekta SL25 linear accelerator for small fields and intensity modulated radiation therapy (IMRT) treatments in inhomogeneous media. The accuracy of AAA was evaluated in two studies. First, AAA was compared both with Monte Carlo (MC) and the measurements in an inhomogeneous phantom simulating lung equivalent tissues and bone ribs. The algorithm was tested under lateral electronic disequilibrium conditions, using small fields (2x2 cm"2). Good agreement was generally achieved for depth dose and profiles, with deviations generally below 3% in lung inhomogeneities and below 5% at interfaces. However, the effects of attenuation and scattering close to the bone ribs were not ...

2007-05-01

269

Molecular-beam/surface-science apparatus for state-resolved chemisorption studies using pulsed-laser preparation  

International Nuclear Information System (INIS)

We describe a new apparatus that combines pulsed laser excitation in a molecular beam with surface-science methods for preparation of clean single-crystal surfaces and detection of adsorbates to enable state-selected studies of gas-surface reaction dynamics. Reactant molecules are prepared in specific vibrationally excited states via overtone pumping using tunable, narrow-band laser radiation. The collision-free environment of the molecular beam prevents relaxation of the prepared molecules before impact on the target surface and enables complete control over the collision energy and incidence angle. Chemisorption products are detected after a given deposition time by Auger electron spectroscopy. To achieve sufficient beam flux of state-selected reactant molecules for product detection by standard surface-science techniques, we use a high-intensity, short-pulse molecular-beam source matched to the low duty cycle of the pulsed lasers used in our ...

2003-09-01

270

Korea-Japan Joint Research on Development of Seismic Capacity Evaluation and Enhancement Technology Considering Near-Fault Effect  

Energy Technology Data Exchange (ETDEWEB)

Several recent improved methods for the EGFM are introduced in order to avoid artificial holes seen in the synthetic acceleration spectrum. Furthermore evaluation of input ground motions at Wolsung NPP are performed by varying the source parameters that may control the high-frequency wave radiation and the deviation of the synthetic motions are revealed. The PSHA case studies for four NPP sites (Wolsung, Kori, Uljin, Younggwang) are performed. In the analysis, site-specific attenuation equations developed for Korean NPP sites are employed, and the seismic hazards for the target sites are evaluated in the case where the four kind of seismic source models are considered. Moreover, the PSHA for Wolsung and Younggwang are conducted by using the site-specific attenuation equation with the index of response spectra and the uniform hazard spectra are evaluated for the two sites. The supporting tool for seismic response analysis and the evaluation tool ...

2005-12-15

271

Evaluation of Beta-Absorbed Fractions in a Mouse Model for 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177Lu Radionuclides  

Energy Technology Data Exchange (ETDEWEB)

Several short-lived, high-energy beta emitters are being proposed as the radionuclide components for molecular-targeted potential cancer therapeutic agents. The laboratory mice used to determine the efficacy of these new agents have organs that are relatively small compared to the ranges of these high-energy particles. The dosimetry model developed by Hui et al. was extended to provide realistic beta-dose estimates for organs in mice that received therapeutic radiopharmaceuticals containing 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177 Lu. Major organs in this model included the liver, spleen, kidneys, lungs, heart, stomach, small and large bowel, thyroid, pancreas, bone, marrow, carcass, and a 0.025-g tumor. The study as reported in this paper verifies their results for 90Y and extends them by using their organ geometry factors combined with newly calculated organ self-absorbed fractions from PEREGRINE and MCNP. PEREGRINE and MCNP agree to within 8% for the worst-case ...

2005-08-01

272

Continuous intensity map optimization (CIMO): A novel approach to leaf sequencing in step and shoot IMRT  

International Nuclear Information System (INIS)

A new leaf-sequencing approach has been developed that is designed to reduce the number of required beam segments for step-and-shoot intensity modulated radiation therapy (IMRT). This approach to leaf sequencing is called continuous-intensity-map-optimization (CIMO). Using a simulated annealing algorithm, CIMO seeks to minimize differences between the optimized and sequenced intensity maps. Two distinguishing features of the CIMO algorithm are (1) CIMO does not require that each optimized intensity map be clustered into discrete levels and (2) CIMO is not rule-based but rather simultaneously optimizes both the aperture shapes and weights. To test the CIMO algorithm, ten IMRT patient cases were selected (four head-and-neck, two pancreas, two prostate, one brain, and one pelvis). For each case, the optimized intensity maps were extracted from the Pinnacle"3 treatment planning system. The CIMO algorithm was applied, and the optimized aperture shapes and weights were ...

2006-04-01

273

Cellular dosimetry: Absorbed fractions for monoenergetic electron and alpha particle sources and S-values for radionuclides uniformly distributed in different cell compartments  

Energy Technology Data Exchange (ETDEWEB)

The importance of cellular dosimetry in both diagnostic and therapeutic nuclear medicine is becoming increasingly recognized. Experimental range-energy relations for electrons and alpha particles, along with derived geometric reduction factors, are used to calculate cellular absorbed fractions for these radiations. The resulting absorbed fractions are employed to calculate cellular S-values for several radionuclides. Cellular absorbed fractions for monoenergetic electron sources with energies ranging from 0.1 keV to 1 MeV, distributed uniformly in the source region, are calculated for several target {l_arrow} source combinations including cell{l_arrow}cell, cell{l_arrow}cell surface, nucleus{l_arrow}nucleus, nucleus {l_arrow}cytoplasm and nucleus {l_arrow}cell surface. Similar data are also provided for monoenergetic alpha particle sources with energies ranging from 3 to 10 MeV. S-values are also conveniently tabulated for {sup 32}P, {sup 35}S, ...

1994-02-01

274

Cell death (apoptosis) in mouse intestine after continuous irradiation with gamma rays and with beta rays from tritiated water  

Energy Technology Data Exchange (ETDEWEB)

Apoptosis is a pattern of cell death involving nuclear pycnosis, cytoplasmic condensation, and karyorrhexis. Apoptosis induced by continuous irradiation with gamma rays (externally given by a 137Cs source) or with beta rays (from tritiated water injected ip) was quantified in the crypts of two portions of mouse bowel, the small intestine and descending colon. The time-course change in the incidence of apoptosis after each type of radiation could be explained on the basis of the innate circadian rhythm of the cells susceptible to apoptotic death and of the excretion of tritiated water (HTO) from the body. For 6-h continuous gamma irradiation at various dose rates (0.6-480 mGy/h) and for 6 h after injection of HTO of various radioactivities (0.15-150 GBq per kg body wt), the relationships between dose and incidence of apoptosis were obtained. Survival curves were then constructed from the curves for dose vs incidence of apoptosis. For the calculation of the absorbed ...

1989-04-01

275

An Assessment of the Detection of Highly Enriched Uranium and its Use in an Improvised Nuclear Device using the Monte Carlo Computer Code MCNP-5  

Science.gov (United States)

In 2002 and again in 2003, an investigative journalist unit at ABC News transported a 6.8 kilogram metallic slug of depleted uranium (DU) via shipping container from Istanbul, Turkey to Brooklyn, NY and from Jakarta, Indonesia to Long Beach, CA. Targeted inspection of these shipping containers by Department of Homeland Security (DHS) personnel, included the use of gamma-ray imaging, portal monitors and hand-held radiation detectors, did not uncover the hidden DU. Monte Carlo analysis of the gamma-ray intensity and spectrum of a DU slug and one consisting of highly-enriched uranium (HEU) showed that DU was a proper surrogate for testing the ability of DHS to detect the illicit transport of HEU. Our analysis using MCNP-5 illustrated the ease of fully shielding an HEU sample to avoid detection. The assembly of an Improvised Nuclear Device (IND) -- a crude atomic bomb -- from sub-critical pieces of HEU metal was then examined via Monte Carlo ...

2007-04-01

276

Including the relativistic kinetic energy in a spline-augmented plane-wave band calculation  

International Nuclear Information System (INIS)

The first-order relativistic correction to the kinetic energy of an electron, the mass-velocity term, is not bounded from below. It can, therefore, not be used within a variational framework. To overcome this deficiency we developed a method to include the entire relativistic kinetic energy #sq root#(p"2c"2+m_0"2c"4)-m_0c"2 in a spline-augmented plane-wave band calculation. The first results for silver are quite promising, especially for d and p states: The analysis of the energies of the core states as well as of the valence band structure suggests that the energies of d bands are reproduced within 1 mRy. However, the combination of the relativistic kinetic energy with the Darwin term leads to energies which are too low for s-like valence states by 10 mRy. Therefore, the s and d valence band complex is spread out and the Fermi level is lowered by the same amount as the s states. We expect to overcome these deficiencies in future investigations ...

277

Development of the discrete-time adaptive sliding mode power system stabilizer  

Energy Technology Data Exchange (ETDEWEB)

A newly developed discrete-time adaptive sliding mode power system stabilizer (PSS) is proposed in this paper. Because the proposed PSS is developed in the pure discrete-time domain it is able to maintain the stability with the rather slower smapling frequency compared to discretized conventional continuous-time sliding mode PSS. The proposed PSS has the three main superiorities to the conventional PSS. First, because the proposed PSS utilizes the sliding mode control method, it has the strong robustness to the variations of the system parameters. Hence, it can overcome the minor disturbances such as identification errors, modeling errors, etc. Second, the proposed PSS needs only input/output measurements as feedback signals. Hence, it does not need the measurements of the state variables as the conventional sliding mode PSS or PSS based on the linear quadratic control method does. Finally, because the proposed PSS have the adaptive property, it is able to ...

1996-12-31

278

Computer image analysis of wear debris for machine condition monitoring and fault diagnosis  

Energy Technology Data Exchange (ETDEWEB)

Whenever moving surfaces interact, wear particles are produced. Microscopic examination of the morphology of such wear debris is an accepted method for machine condition monitoring and fault diagnosis. Wear particle analysis has not, however, been widely accepted in industry because it is dependent on expert interpretation of particle morphology and relies on subjective assessment criteria. Consequently, the methods are time consuming and expensive and are not always consistent. The use of automated computer image analysis systems to assess the morphology of debris promises to overcome these limitations by making the methods more time and cost efficient, and also more consistent and effective. The first step required for automation of the analysis procedure is to develop objective criteria for assessing the wear particle morphology. Numerical parameters to describe the morphology have been developed and are outlined in this paper. A system using such techniques ...

1995-03-01

279

The European Regulation no. 761/2001 EMAS  

International Nuclear Information System (INIS)

The Regulation 761/2001 EMAS (Environmental Management and Audit Scheme), introduced by the 1836/93 Community regulation, is one of the tools activated by the European Union in order to apply the 5. and 6. Community Environmental Programme, in the field of firm-environment interactions at first (overcoming the old Command and Control logic), then by extending its applicability to ali Organisations. EMAS is a voluntary tool that enables Organisations to evaluate their own interaction with the Environment, to plan and check the yearly improvement of their environmental performance, providing the public documented relevant information. The report illustrates the procedure far applying this regulation, its implementation and new application trends in Italy and the advantages far firms.

280

Open-pit explosives  

Energy Technology Data Exchange (ETDEWEB)

This paper explains how mine operators are taking a closer look at the power of explosives and how primary breakage affects other open-pit mining costs. Slurries have overcome most of the disadvantages attributed to them in their early years and may replace Anfo. Effective blasting is the key to an efficient, low-cost mining operation. Reviews are presented on research in crater studies, computer-aided design, the expanding gas theory, and high-speed motion picture cameras that show the importance of shock energy in fracturing the rock interfaces throughout the burden. The paper concludes with MSHA-approved courses in blasting offered throughout the US.

1982-07-01

281

Moessbauer diffraction measurements on polycrystalline bcc iron  

Energy Technology Data Exchange (ETDEWEB)

In the early days of Moessbauer spectroscopy, it was demonstrated that coherent scattering of photons emitted by a Moessbauer source can be observed. In spite of the fact that scattering experiments could give information not accessible by the absorption method, they are not widely used. The reasons for this are, on the one hand, experimental difficulties, and on the other hand, the form of the samples, which should be large single crystals in most cases. In this work, we present a Moessbauer diffraction measurement on polycrystalline bcc iron where these problems have been overcome. We demonstrate that using the kinematical theory of gamma-ray diffraction, useful information on the relative orientation of the crystallographic axis to the hyperfine field directions can be subtracted. (orig.)

1994-11-01

282

Method for harvesting, cleaning, and treating achenes of guayule (parthenium argentatum gray)  

Energy Technology Data Exchange (ETDEWEB)

Procedures are described to mechanize partially harvesting, cleaning, and pretreatment of guayule achenes. Achenes are harvested with a vacuum insect net and cleaned by a series of screening, threshing, and forced air separations, then treated to overcome seed coat impermeability in a semiautomatic system that presoaks, treats with 0.5% sodium hypochlorite, and rinses. Achenes may be sown immediately or dried for storage. Procedures outlined involve commercially available equipment with a minimum of custom construction and are adaptable to small or large operations. (Refs. 11).

1981-06-01

283

Investigations for obtaining enhanced SHG element of KH_2PO_4 crystal  

International Nuclear Information System (INIS)

We report investigations of enhancement in material conversion efficiency of KDP for SHG applications. The limitation of conventional technique of growing KDP crystal was overcome in the present work by adopting a growth method to grow KDP directly in type-II phase matching direction. The conventional technique results in #approx#30% of the crystal volume usable for SHG applications whereas the present method has resulted in enhancing it to #approx#90%. The orientation of the element was confirmed by frequency conversion experiment using Nd:YAG laser. The UV-vis transmittance obtained was 92%. The interferometric results show that the crystals have excellent optical homogeneity.

2010-04-01

284

Hope versus nursing  

British Library Electronic Table of Contents (United Kingdom)

Hope is an essential dimension of life. Hope, according to Marcel?s thinking, is the act by which the temptation to despair is actively overcome. Hope comes alive when confronting life?s trials, darkness, illness and separation. Marcel differentiates ?I hope? from ?I hope that?. Hope as a central construct for nursing has been analysed, defined, and studied by the nursing theorist Jean Watson in her Theory of Human Caring, and Kaye Herth with her strategies (Herth Hope Index). These strategies are based on Marcel?s existential notion that human beings have an endless possibility of improving their own being.

2010-01-01

285

Go vs. no-go - potential and limitations of continuous-variable quantum computing by measurements  

Energy Technology Data Exchange (ETDEWEB)

In this talk, we explore the feasibility of quantum computation using continuous-variable systems by means of local measurements only. In the first part of the talk, we will identify crucial limitations that arise when starting from Gaussian cluster states. This is done by resorting to a Gaussian projected entangled pair picture as well as to notions of continuous-variable quantum repeater networks. In the second part, we look at instances in which these limitations can be overcome, and how suitable encodings of qubits in oscillators and feasible non-Gaussian resource states give rise to universal schemes for quantum computing.

2010-07-01

286

Giving voice to the past: digitizing oral history  

British Library Electronic Table of Contents (United Kingdom)

Purpose - The purpose of this paper is to describe the processes and procedures utilized by Jacksonville State University's Houston Cole Library to digitize an oral history collection and provide access to it through the Library's catalog, web presence, and the state-wide digital repository initiative, Alabama Mosaic (see www.alabamamosaic.org). Design/methodology/approach - The paper is based on the Library's experiences in acquiring, digitizing, creating metadata for and making accessible a collection of oral histories. Findings - The paper describes the obstacles overcome, issues encountered, procedures established, and ramifications of the project. Practical implications - Many institutions are currently digitizing unique collections as part of repository initiatives, both institutiona...

2009-01-01

287

From gene manipulation to forest establishment: shoot cultures of woody plants can be a central tool  

Energy Technology Data Exchange (ETDEWEB)

Establishing germplasm of woody plants in microculture as shoot cultures has proved to be an effective method of overcoming many of the obstacles in working with these crops. Shoot cultures eliminate the changes associated with seasonal growth cycles and phase change and put large plants into a more manageable form. Well-established shoot cultures are central to successful clonal propagation systems for forest trees as well as to genetic improvement based on the use of cellular techniques such as protoplast manipulation. The physiological basis as to why tissues from shoot cultures are so readily manipulated is not well understood.

1985-05-01

288

Financing `Orbital Power and Light Inc`  

Energy Technology Data Exchange (ETDEWEB)

Financing space solar power generation programmes has several inherent difficulties. Such large-scale projects are usually easily defined with an expected economic return, construction time, useful service life and defined management structure. As yet, solar power satellites for power generation possess none of these as the idea exists conceptually and the technology still needs to be developed. Methods for overcoming these uncertainties and securing financial backing are described. Venture capital could finance a research/marketing firm. US Government support through a cost plus short-term monopoly to facilitate private debt financing could provide an answer. (UK)

1998-06-01

289

Clean Technology Application : Kupola Model Burner for Increasing the Performance of Spent Accu Recycle  

International Nuclear Information System (INIS)

Recycling of used battery for recovering lead done by either small household/small scale industries has been identified as a source of air pollution, especially by heavy metal (Pb). This condition give an adverse impact toward workers and societies. Technological aspect is one of the causal. The process apply an open system. Therefore, a lot of energy, as well as dust wasted to the air without prior treatment. For overcoming this condition, closed system by utilizing Cupola furnace will be offered as one of the alternatives clean technology application and to increase the recovering performance in order to set an effective and efficient result. (author)

2000-02-01

290

Characterisation of anti-Staphylococcus aureus activity of quercetin  

British Library Electronic Table of Contents (United Kingdom)

Summary Although many antibiotics are available for the treatment of bacterial infections, the emergence and global spread of antibiotic-resistant bacteria is a community-wide problem. To overcome this problem, we must explore alternative antimicrobials. This study investigated the antibacterial properties of quercetin, a flavonoid present in vegetables and fruits. Quercetin was tested against gram-positive and gram-negative bacteria and was found to exert selective antibacterial activity against Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), and Staphylococcus epidermidis. Some clinical MRSA strains showed remarkable susceptibility to quercetin. In combination with antibiotics, such as oxacillin, ampicillin, vancomycin, gentamicin, and erythromycin, quercetin sho...

2010-01-01

291

Application of relationship marketing and management: a large contractor case study  

British Library Electronic Table of Contents (United Kingdom)

Marketing-led enterprise change management initiated by a major UK contractor is explored in this paper as a contrast to procurement-led changes to projects driven by clients. Procurement-led initiatives try to induce changes to behaviour through market governance. Relationship marketing and management proactively change organizational behaviour, the enterprise taking responsibility for its own destiny. Investment and resource allocation, and organizational behaviour have posed constraints, particularly concerning service continuity in construction. Overcoming these constraints offers opportunities for delivering service improvements and adding value for clients and yielding further increases in repeat business and increasing profitability. Relationship marketing is the conceptual starting...

2009-01-01

292

Selection of IFE target materials from a safety and environmental perspective  

International Nuclear Information System (INIS)

Target materials for inertial fusion energy (IFE) power plant designs might be selected for a wide variety of reasons including wall absorption of driver energy, material opacity, cost and ease of fabrication. While each of these issues are of great importance, target materials should also be selected based upon their safety and environmental (S and E) characteristics. The present work focuses on the recycling, waste management and accident dose characteristics of potential target materials. If target materials are recycled so that the quantity is small, isotopic separation may be economically viable. Therefore, calculations have been completed for all stable isotopes for all elements from lithium to polonium. The results of these calculations are used to identify specific isotopes and elements that are most likely to be offensive as well as those most likely to be acceptable in terms of their S and E ...

2001-05-21

293

Mode of action of membrane-disruptive lytic compounds from the marine dinoflagellate Alexandrium tamarense  

British Library Electronic Table of Contents (United Kingdom)

Certain allelochemicals of the marine dinoflagellate Alexandrium tamarense cause lysis of a broad spectrum of target protist cells but the lytic mechanism is poorly defined. We first hypothesized that membrane sterols serve as molecular targets of these lytic compounds, and that differences in sterol composition among donor and target cells may cause insensitivity of Alexandrium and sensitivity of targets to lytic compounds. We investigated Ca^2^+ influx after application of lytic fractions to a model cell line PC12 derived from a pheochromocytoma of the rat adrenal medulla to establish how the lytic compounds affect ion flux associated with lysis of target membranes. The lytic compounds increased permeability of the cell membrane for Ca^2^+ ions even during blockade of Ca^2^+ channels wit...

2011-01-01

294

An identification method of positron production in laser beam interaction with targets  

Energy Technology Data Exchange (ETDEWEB)

A simple electromagnetic transport system was constructed to identify very rare positrons produced in a powerful laser beam interaction with a target. Testing experiments were carried out with CO[sub 2]-laser (10[sup 12] W/cm[sup 2]) beam pulses ([tau] = 50 ns, f = 0.01 Hz) focused on the copper target, as well as with a 96 MeV alpha-particle beam irradiated carbon target. The results showed that the developed system could be effectively used for positron identification and evaluation of their energy by means of a time-of-flight method. The computerized system to deal with this problem, together with others related to the power laser beam interaction with targets, has been constructed. (orig.).

1992-10-01

295

Activation analysis of target debris in the national ignition facility  

International Nuclear Information System (INIS)

The modeling methods used to compute the neutron-induced activation of target and near-target materials in the NIF facility are presented. A detailed space and energy description of the neutron environment in the different materials is provided. A new capability has been developed to treat in a general way the activation of debris produced in an operational regime of yield and no-yield experiments. First calculations are addressed to analyze the activity of the debris into the target chamber. The contribution of the different components to activity, interior dose rates, and waste disposal rating (WDR) is determined. The importance of the activation coming from primary irradiation in the target, and from secondary irradiation in debris deposited onto the first wall is assessed. Finally, waste hazards of the activated debris when removed out of the chamber and stored are analyzed. (authors)

1999-09-12

296

The benefits of low level radiation  

Energy Technology Data Exchange (ETDEWEB)

The assumed linear relationship between exposure to radiation and cancer incidence is questioned in this article. The current research data on radiation effects at the cellular level is reviewed, as are epidemiological studies of background radiation effects and health effects of populations exposed to low levels of radiation exposure via employment or medical treatments. Statistics reveal that threshold levels currently in force need to be reviewed. Some evidence of beneficial effects of low level radiation exposure effects of low level radiation exposure is also presented, and so regulations should be reviewed at an international level. (UK).

1997-06-01

297

Stimulated radiation of high - current relativistic electron beams  

International Nuclear Information System (INIS)

The most propagated mechanisms of stimulated radiation of electron beam such as Cherenkov one-particle and collective effects, ondulator and magnetic bremsshrahlung radiations, Doppler anomalous effect, Thompson and Raman scattering and radiation are discussed. Relation of spontaneous radiation mechanisms of individual electron and stimulated radiation effects in electron beams has been elucidated, grounds of linear electrodynamics of radiative beam instabilities are stated, and main mechanisms of their nonlinear stabilization are elucidated as well. Various simulated processes in electron beams are considered from the unique point of view using a simple mathematical apparatus and such physical laws as conservation and Newton laws.

1987-01-01

298

[Improvement of the recognition probability about camouflage target based on BP neural network].  

Science.gov (United States)

Using static Michelson interferometer to get the spectrum information of measurement targets for spectrum identification, under the condition that the interference length is constant, the system can be optimized by BP neural network algorithm for the mixed spectral separation process. Thereby it can realize improving the recognition probability of camouflage target. Collecting the spectrum information in field of view (FOV) by the interferometer and linear array CCD detector, composing the set of mixed spectrum data, with known absorption spectrum of the material as a hidden layer of rules, it used BP neural network to separate the mixed spectrum data. Experiment with different distances, different combinations of mixed background spectrum as the initial data, using steel target (size: 1.5 m x 1.5 m) made of four kinds, the recognition probability of non-camouflage target is about 90% by BP neural ...

2010-12-01

299

Traffic and transport in the Dutch National Environmental Outlook 4; Verkeer en vervoer in de Nationale Milieuverkenning 4  

Energy Technology Data Exchange (ETDEWEB)

In the Fourth Dutch National Environmental Outlook (NMP, abbreviated in Dutch) of the National Institute of Public Health and the Environment (VROM), published in July 1997, possible future developments in the traffic and transport sector in the Netherlands are described for the period 1995-2020 and also evaluates present Dutch policies. NMP-4 also offers possible solutions for expected environmental problems. This report serves as a background document for the traffic and transport sector. With a view to present Dutch policies, the main conclusions drawn from the Outlook are that: (1) the policy targets for car and lorry use for 2010 will not be met, (2) the target for CO2 emissions from road transport for 2010 will not be met, (3) the NOx emission target for 2010 will be met for cars, but not for trucks, (4) the VOC emission target for 2010 will be met for cars, but not for trucks, and (5) the noise ...

1998-03-01

300

Radiation protection. A guide for scientists and physicians  

International Nuclear Information System (INIS)

This manual was written for individuals who wish to become qualified in radiation protection as an adjunct to working with sources of ionizing radiation or using radionuclides in the field of medicine. It provides the radiation user with information needed to protect himself and others and to understand and comply with governmental and institutional regulations regarding the use of radionuclides and radiation machines. It is designed for a wide spectrum of users, including physicians, research scientists, engineers, and technicians. It should be useful also to radiation safety officers, members of radiation safety committees, and others who are responsible for the proper use of radiation sources, although they may not be working with the sources directly. The presentation in this manual is designed to obviate the need for reviews of atomic ...

301

Combining satellite data and models to estimate cloud radiative effect at the surface and in the atmosphere  

British Library Electronic Table of Contents (United Kingdom)

Abstract Satellite measurements and numerical forecast model reanalysis data are used to compute an updated estimate of the cloud radiative effect on the global multi-annual mean radiative energy budget of the atmosphere and surface. The cloud radiative cooling effect through reflection of short wave radiation dominates over the long wave heating effect, resulting in a net cooling of the climate system of - 21 Wm-2. The short wave radiative effect of cloud is primarily manifest as a reduction in the solar radiation absorbed at the surface of - 53 Wm-2. Clouds impact long wave radiation by heating the moist tropical atmosphere (up to around 40 Wm-2 for global annual means) while enhancing the radiative cooling of the atmosphere over other regions, in particular higher latitudes and sub-trop...

2011-01-01

302

Biological effects of electromagnetic radiation in the microwave range  

Energy Technology Data Exchange (ETDEWEB)

The book examines current experimental and clinical knowledge concerning the biological and biophysical effects of electromagnetic radiation, particularly that in the microwave range. The biophysical bases of the interaction of electromagnetic radiation with matter are reviewed with emphasis on biological systems, and the effects of radiation on critical biological systems, including the nervous, reproductive, visual and blood-forming systems are compared. Data concerning the lethal effects of nonionizing radiation is presented and characteristics of the effects of electromagnetic radiation on the whole mammalian organisms are examined. Various reactions of the neuroendocrine system to electromagnetic radiation are described, with particular attention given to the adrenal system, and the combined effects of ionizing and microwave radiation ...

1980-01-01

303

[The indicators of biological age and accelerated aging in liquidators of the consequences of radiation emergency].  

Science.gov (United States)

The biological age (BA) of the majority of the liquidators of the consequences of the radiation accidents in the Navy and of the liquidators of the Chernobyl' APS accident exceeds the medium standard and the DBA (due BA). The index of the BA can be a characteristic of the influence of the social-hygienic factors on the health condition of the Special Risk Subunit--the liquidators of the consequences of the radiation accidents. It was established, that the radiation influence concerns to the factors dramatically increasing the BA and the rate of senescence of the liquidators of the consequences of the radiation accidents. PMID:21809627

2011-01-01

304

The THz Radiation from Undulator  

Science.gov (United States)

The experimental device for generation of undulator radiation in terahertz wavelength region by use of undulator with ferromagnets is created. The device is based on a beam of a microtron with the energy 7.5 MeV. The radiation wavelength is 200 mu. Registered spontaneous radiation has a power 10{sup -6} W at a current of a beam 2 mA in a pulse. With the optical resonator, in a mode, the amplification of 6% is received, that in sometimes is more than the expected value. This effect is explained as a result of partial coherence of radiation.

2010-02-03

305

Study of emission of Cerenkov radiation by tachyons  

Energy Technology Data Exchange (ETDEWEB)

The emission of Cerenkov radiation by tachyons has been examined by using the reduced expansions of superluminal electromagnetic fields in terms of standard helicity representation of Poincare group. It has been shown that the tachyons emit Cerenkov radiation through their coupling only with subluminal electromagnetic fields and that a charged tachyon can emit Cerenkov radiation only in the media in which it travels with a velocity lower than that of light while in the usual medium in which its velocity is more than that of light, it will never emit Cerenkov radiation.

1983-01-01

306

Radiation facility with electron accelerator of the Institute for Nuclear Research of Ukraine, Kiev  

International Nuclear Information System (INIS)

Characteristics of the Ukrainian NSA NRI radiation facility for scientific researches and developments of industrial radiation technology are performed. Parts of the facility, design peculiarities of technical tools are described. Biological protection of the facility and radiation protection system, transport line, systems of technical provision and radiation measurements are discussed

2003-02-01

307

Radiation exposure of the population of the GDR by X-ray diagnostics  

International Nuclear Information System (INIS)

The radiation burden of the people of the GDR in relation to biomedical radiography altogether as well as organ doses, gonad doses and genetically significant doses in detail are outlined. The concepts of radiation protection and standards of radiographic examination are demonstrated. Possibilities of influencing radiation exposure by scientifically based indication of X-ray examination, application of new and improvement of usual examination techniques are discussed with regard to quality assurance and control. Proposals concerning the reduction of radiation exposure of the GDR population are presented.

1986-01-01

308

Potential Hazards from Neutrino Radiation at Muon Colliders  

CERN Document Server

High energy muon colliders, such as the TeV-scale conceptual designs now being considered, are found to produce enough high energy neutrinos to constitute a potentially serious off-site radiation hazard in the neighbourhood of the accelerator site. A general characterization of this radiation hazard is given, followed by an order-of-magnitude calculation for the off-site annual radiation dose and a discussion of accelerator design and site selection strategies to minimize the radiation hazard.

1999-01-01

309

Model of quantum noise of shadow radiation images  

International Nuclear Information System (INIS)

Correlation characteristics of quantum noise on the shadow radiation image (RI) of the object under nondestructive testing are studied. Mathematical model of RI occasional distortions is derived. The model takes into account the parameters of object under testing and of radiation beam by radiation quanta flux density. The results obtained can be used as a component in the process of investigation of various radiation testing systems

310

Coherent oscillator radiation  

International Nuclear Information System (INIS)

Coherent oscillator radiation is considered. A comparison is made with classical particle radiation with gauss distribution. Decay probability for coherent state in spontaneous radiation is estimated. The method suggested for describing harmonic oscillator allows to separate the effect of classical field radiation from quantum description of particle state within the framework of a self-consistent quantum mechanical problem.

1982-04-01

311

Study of particles trapped by a magnetic field  

Science.gov (United States)

A new type of radiation which occurs when particles are accelerated in the field of a longitudinal wave and in a transverse magnetic field is studied. The characteristics of such spontaneous radiation are obtained, and the influence of collective effects on the radiation is analyzed. The application of the findings to the theory of free electron lasers is discussed. 8 references.

1986-01-01

313

Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries  

UK PubMed Central (United Kingdom)

Objectives To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental,...Full Text Available

2005-07-09

314

Radiation therapy alone versus radiation therapy and chemotherapy in the management of Hodgkin's disease.  

UK PubMed Central (United Kingdom)

Forty-four patients with histologically proven Hodgkin's disease underwent initial treatment with extended-field radiation therapy. Nineteen of these patients also received combination chemotherapy....Full Text Available

1990-02-01

315

Radiation exposure due to X-rays of the hip joint in babies  

International Nuclear Information System (INIS)

Exact anatomic knowledge about the location of the gonads and the application of corresponding measures of radiation protection are the preconditions for an efficient reduction of the danger of a possible genetic damage as a result of radiation exposition during X-ray examination of the hip joint of newborns. (VJ).

316

Multiscale registration of planning CT and daily cone beam CT images for adaptive radiation therapy  

UK PubMed Central (United Kingdom)

Adaptive radiation therapy (ART) is the incorporation of daily images in the radiotherapy treatment process so that the treatment plan can be evaluated and modified to maximize the amount of radiation...Full Text Available

2009-01-01

317

Lagranzheva dinamika kollektivnykh vzaimodejstvij v potokakh diskretnykh izluchatelej. (Lagrange dynamics of collective interactions in flows of discrete radiators).  

Science.gov (United States)

Analytical method of theoretical simulation of collective hydrodynamic instabilities of intensive flows of discrete radiators, interacting with each other only through the coherent fields of their spontaneous radiation in corresponding media was suggested...

1989-01-01

318

Granite Countertops and Radiation | Radiation Protection | US EPA  

Wastenet

... Top of page Testing Radiation coming from granite countertops results from natural radioactive material in the granite. Identifying the presence and concentration of radioactive elements in granite requires expensive and sophisticated portable instruments or laboratory equipment. These instruments and equipment require proper calibration, and interpretation of ...

319

Are natural radioactive materials dangerous  

International Nuclear Information System (INIS)

The different radiation loads caused by natural and artificial radionuclides are compared in this paper. This examples will serve to illustrate that the problem of population exposure to radiation can only be solved in consideration of all components and to show which effects of the radiation from natural sources are of special importance in this connexion. (orig./AK).

1974-09-23

320

A radiator of electromagnetic waves with a combined shape of generatrices  

British Library Electronic Table of Contents (United Kingdom)

The problem of optimizing a horn radiator of electromagnetic waves for the reflection coefficient and the coefficient of transformation of the fundamental mode into higher order modes is solved. Optimization is performed by means of selecting a combined shape of the radiator generatrices.

2008-01-01

321

Using ICCD as a fast optical switch to measure harmonic super-radiation from an optical klystron in a storage ring  

International Nuclear Information System (INIS)

An optical klystron is built in the 800 MeV electron storage ring at University of Science and Technology of China for harmonic super-radiation generation. In single bunch operation mode the repetition rate of the spontaneous radiation pulses is about 4.533 MHz, and the repetition rate of the seed laser pulses is about 3 Hz, while the radiation pulse duration is 300 ps. For measuring harmonic radiation a high on/off ratio ICCD is used as an optical switch to reject spontaneous radiation pulses of high repetition rate

2001-07-01

322

The medical exposures to ionizing radiations, it is a world priority in radiation protection  

International Nuclear Information System (INIS)

The document published under A/63:46 and titled report of the scientific committee of United Nations for the study of ionizing radiations effects, gives the situation of the fifty sixth session of the committee that stood at Vienna from the 10. to 18. july 2008. In the chapter 3 of this report the writers summarize the strategic planning and the working program of the scientific committee for the period 2009-2013. They note that the committee worry about the inadequate means, particularly in personnel. The priorities for the given period will be the medical exposure of patients, the radiation levels and the effects of energy production, the exposure to natural radiation sources and the improvement of the understanding of the effects of the low doses radiation exposure. (N.C.)

323

x - NASA Technical Reports Server  

Science.gov (United States)

Mar 1, 2011 ... Radionuclide X-ray fluorescence analysis. 2: Detection of the X-ray fluorescence radiation excited by radionuclide radiation ...

324

VOLUME I11 IMISSION SYSTEM PERFORMANCE - NASA Technical Report ...  

Science.gov (United States)

Nov 8, 2010 ... Ihring Mission 11, the radiation dosimetry measurement system functioned normally and provided data on the Earth's trapped radiation belts ...

325

Treatment of persons exposed in radiation accidents or nuclear explosions. Omhaendertagande av skadade vid radiakolyckor och kaernvapenexplosioner  

Energy Technology Data Exchange (ETDEWEB)

The report gives general principles of treatment and care of casualties caused by radiation accidents or nuclear explosions.

1991-01-01

326

The importance of radiation quality for optimisation in radiology  

UK PubMed Central (United Kingdom)

Selection of the appropriate radiation quality is an important aspect of optimisation for every clinical imaging task in radiology, since it affects both image quality and patient dose. Spreadsheet...Full Text Available

328

Tachyon Cerenkov radiation  

Energy Technology Data Exchange (ETDEWEB)

By proposing the four-dimensional, reciprocity transformations the appropriate condition for superluminal electromagnetic Cerenkov radiation is obtained by introducing the hypothesis that tachyons possess vector energy and scalar momentum.

1985-09-01

329

Solar Cell Radiation Response near the Interface of Different ...  

Science.gov (United States)

... Solar Cell Radiation Respinnse Near the Interface o~f fliffprerv- ... 5 4. CALCUTl-ATED SOLAR CELL RLSPONSE FOR VARIOUS BASE MATERIALS ...

1971-11-01

330

Relationship of Optical Coating on Thermal Radiation ...  

Science.gov (United States)

drical Enclosures Using a Numerical Ray Tracing Technique. NASA. TM-I02527, 1990 . Buckley, H.: Radiation from the Interior of a Reflecting Cylinder. Philos. ...

331

References | Radiation Protection | US EPA  

Wastenet

...References | Radiation Protection | US EPA This page provides links to the reference material on EPA's Radiation Protection Web site. U.S. EPA/...OAR/ORIA/Radiation Protection Division Jump to main content. Radiation Protection Contact Us Search: All EPA This Area You are here: EPA Home ... Radiation Protection References PageName Technical Users General Public Reporters Librarians Students/Teachers PROGRAMS TOPICS REFERENCES References The Reference Section provides general material that support the ...other sections of EPA's Radiation Protection Web site. You will find links within the information to related pages throughout the Radiation Protection , EPA ...

332
333

Radiation deamination of tetracycline. [Gamma radiation  

Energy Technology Data Exchange (ETDEWEB)

The fundamental product of tetracycline hydrochlorine gamma radiolysis was separated in its solid state. From the results of spectroscopic studies it has been established that it is des-N,N-dimethylaminotetracycline.

1980-01-01

334

Radiation Damage Calculations for the FUBR and BEATRIX Irradiations of Lithium Compounds in EBR-II and FFTF  

Energy Technology Data Exchange (ETDEWEB)

Radiation Damage Calculations for the FUBR and BEATRIX Irradiations of Lithium Compunds in EBR-II and FFTF

1999-05-01

335

Onclas U9800 - NASA Technical Report Server (NTRS)  

Science.gov (United States)

the probability of its spontaneous radiation de-excitation increases. ... consider spontaneous radiation transitions. We will examine the ...

336

Numerical analysis of methane-air combustion considering radiation effect  

Energy Technology Data Exchange (ETDEWEB)

Turbulent premixed methane-air combustion in a cylindrical chamber is numerically simulated considering radiation effect. Reaction rates are considered as minimum rates between Arrhenius rates and eddy break up rates. A five step reduced mechanism is used. Turbulent modeling is done via standard k-{epsilon} model imposed by empirical inlet boundary conditions. Source terms of energy equation consist of reaction rates and radiation effects. The discrete ordinate method (DOM) is employed to solve the radiative transfer equation (RTE) and the weighted sum of gray gas model (WSGGM) is imposed to consider radiation effect of non-gray gases. The results indicate that in the case of turbulent combusting flows, the effect of radiation of gases can affect the temperature and species concentrations. The numerical results obtained considering radiation effect are closer to ...

2008-12-15

337

Numerical analysis of methane-air combustion considering radiation effect  

International Nuclear Information System (INIS)

Turbulent premixed methane-air combustion in a cylindrical chamber is numerically simulated considering radiation effect. Reaction rates are considered as minimum rates between Arrhenius rates and eddy break up rates. A five step reduced mechanism is used. Turbulent modeling is done via standard k-? model imposed by empirical inlet boundary conditions. Source terms of energy equation consist of reaction rates and radiation effects. The discrete ordinate method (DOM) is employed to solve the radiative transfer equation (RTE) and the weighted sum of gray gas model (WSGGM) is imposed to consider radiation effect of non-gray gases. The results indicate that in the case of turbulent combusting flows, the effect of radiation of gases can affect the temperature and species concentrations. The numerical results obtained considering radiation effect are closer to the ...

2008-12-01

338

Multifunctional, Boron-Foam Based Radiation Shielding  

Science.gov (United States)

PROPOSAL NUMBER: 04 B3.09-7744. SUBTOPIC TITLE: Radiation Shielding to Protect Humans. PROPOSAL TITLE: Multifunctional, Boron-Foam Based ...

339

Mathematical Analysis of Three Free-Electron-Laser Issues  

Science.gov (United States)

... iFfficiency-en- enhanced spontaneous radiation at the free-electron- ... as enhanced spontaneous radiation at the free-electron-laser wavelength. ...

1990-09-30

340

Equipment hardening and hardness assurance  

International Nuclear Information System (INIS)

The introduction of tolerance to radiation (''radiation-hardness'') into large electronic systems is one of the major tasks to which this Handbook will be put. The practices recommended here for inculcating radiation-tolerance in equipment require advanced physical modeling techniques, precise engineering procedures, and firm assurance procedures. The degree to which these procedures should be used in an equipment project can be measured by the severity of the raw radiation environment, the desired reliability of the system, and the requirement of that project for radiation-sensitive technologies. The balance of device/circuit design versus shielding will depend on whether the radiation is highly penetrating -- as in isotope handling or military environments -- or readily attenuated, as in space. In this chapter the authors have attempted to summarize the ...

341

Enhanced coherent undulator radiation from bunched electron beams  

International Nuclear Information System (INIS)

When energetic bunches of electrons traverse an undulator field, they can spontaneously emit radiation both coherently and incoherently. Although it has generally been assumed that undulator radiation is incoherent at wavelengths short compared to the longitudinal size of the electron bunch, several recent observations have proved this assumption false. Furthermore, the appearance of coherent radiation is often accompanied by a significant increase in radiated power. Here we report observations of strongly enhanced coherent spontaneous radiation together with direct measurements, using transition radiation techniques, of the electron distributions responsible for the coherent emission. We also report demonstrated enhancements in the predicted spontaneous radiated power by as much as 6x10"4 using electron bunch compression. copyright 1996 ...

1995-09-28

343

ESR study in radiation damage in pyrimidines. 3-year comprehensive progress report  

International Nuclear Information System (INIS)

General mechanisms of radiation damage to biomolecules was studied by using substituted pyrimidines, particularly barbituric acid derivatives.

344

Differences in synchrotron radiation induced gas desorption from stainless steel and aluminium alloy  

CERN Document Server

Differences in synchrotron radiation induced gas desorption from stainless steel and aluminium alloy

1990-01-01

345

Combined Radiation and Thermal Injury after Nuclear Attack  

Science.gov (United States)

... Except for isolated radiation accidents over the ensuing years, little practical experience has been gained in the treatment of thermal injuries ...

2011-05-13

346

Chinese Journal of Lasers (Selected Articles)  

Science.gov (United States)

... spontaneous radiation of amplifiers within a relatively w~de range of ... pulse widths are 20-30ns, while amplified spontaneous radiation pulse ...

1991-12-10

347

An evaluation of planning techniques for stereotactic body radiation therapy in lung tumors  

UK PubMed Central (United Kingdom)

PurposeTo evaluate four planning techniques for stereotactic body radiation therapy (SBRT) in lung tumors.Methods...Full Text Available

2008-04-01

348

Radioisotope production in the I.Ph.P.E. cyclotron for medical application  

International Nuclear Information System (INIS)

The production methods for seven radioisotopes, Ga-67, Sr-85, Pd-103, In-111, Tu-167, Hg-197 and Pb-203, by using a classical 1.5m cyclotron in the Institute of Physics and Power Engineering, Obninsk, USSR, are described. At present, more than 50 cyclotrons in different countries are used for the production of radioisotopes applied to medicine. Radioisotopes are produced with the cyclotron in the I.Ph.P.E. in the form of irradiated targets, which are delivered to Moscow radiopharmaceutical factory, where radiopharmaceuticals are produced on the base of these targets. The cyclotron is operated in two regimes providing the acceleration of protons, deuterons and alpha -particles. Two types of target assemblies are used for irradiation, the one is intended for the internal beam, and the other is for the external beam. The reactions used for the production of seven radioisotopes described above, the types of ...

349

Radioisotope production in the I. Ph. P. E. cyclotron for medical application  

Energy Technology Data Exchange (ETDEWEB)

The production methods for seven radioisotopes, Ga-67, Sr-85, Pd-103, In-111, Tm-167, Hg-197 and Pb-203, by using a classical 1.5m cyclotron in the Institute of Physics and Power Engineering, Obninsk, USSR, are described. At present, more than 50 cyclotrons in different countries are used for the production of radioisotopes applied to medicine. Radioisotopes are produced with the cyclotron in the I.Ph.P.E. in the form of irradiated targets, which are delivered to Moscow radiopharmaceutical factory, where radiopharmaceuticals are produced on the base of these targets. The cyclotron is operated in two regimes providing the acceleration of protons, deuterons and alpha -particles. Two types of target assemblies are used for irradiation, the one is intended for the internal beam, and the other is for the external beam. The reactions used for the production of seven radioisotopes described above, the types of ...

1982-01-01

350

Distortion-invariant color pattern recognition using multiple phase-shifted-reference-based joint transform correlation incorporating synthetic discriminant function  

Science.gov (United States)

This paper proposes a new pattern recognition system employing optical joint transform correlation (JTC) technique which offers a great number of advantages over similar digital techniques, including very fast operation, simple architecture and capability of updating the reference image in real time. The proposed JTC technique incorporates a synthetic discriminant function (SDF) of the target image estimated from different training images to make the pattern recognition performance invariant to noise and distortion. It then involves four different phase-shifted versions of the same target SDF reference image, which are individually joint transform correlated with the given input scene. When the correlation signals are combined, it produces a single cross-correlation peak corresponding to each potential target present in the given input scene. The proposed technique also includes a fringe-adjusted filter to generate a ...

2011-04-01

351

Uses of laser optical pumping to produce polarized ion beams  

Energy Technology Data Exchange (ETDEWEB)

Laser optical pumping can be used to produce polarized alkali atom beams or polarized alkali vapor targets. Polarized alkali atom beams can be converted into polarized alkali ion beams, and polarized alkali vapor targets can be used to produce polarized H/sup -/ or /sup 3/He/sup -/ ion beams. In this paper the authors discuss how the polarized alkali atom beams and polarized alkali vapor targets are used to produce polarized ion beams with emphasis on the production of polarized negative ion beams.

1983-04-01

352

The HARP experiment first physics results  

CERN Document Server

The HARP experiment at CERN is performing extensive measurements of hadron production cross sections and secondary particle yields, in the momentum range 1.5-15 GeV/c, over the full solid angle and using a large set of cryogenic and solid targets. First measurements of hadron production cross-sections in the forward region are reported using an aluminium target 5% of an interaction length thick and a proton beam of 12.9 GeV/c. A preliminary analysis in the large angle region of elastic scattering events produced with the cryogenic hydrogen target at 3 GeV/c beam momentum is also presented.

2005-01-01

353

Separation of carrier-free "1"7"6","1"7"7W and "1"7"6","1"7"7Ta produced in "1"6O irradiated holmium target  

International Nuclear Information System (INIS)

Carrier-free radionuclides of tungsten and tantalum, "1"7"6","1"7"7W and "1"7"6","1"7"7Ta have been produced by heavy ion activation of holmium target with 97 MeV "1"6O"5"+ beam. Radiochemical separation scheme has been developed to isolate tungsten and tantalum radionuclides from the holmium target matrix. (author)

2001-11-01

354

Separation of carrier free "1"7"6","1"7"7W and "1"7"6","1"7"7Ta radionuclides produced in "1"6O activated holmium metal target  

International Nuclear Information System (INIS)

Carrier-free radioisotopes of tungsten, "1"7"6","1"7"7W, and their corresponding daughter radionuclides "1"7"6","1"7"7Ta, have been produced in holmium target by heavy ion activation with "1"6O"5"+ beam. An attempt has been made to separate these carrier-free radionuclides from bulk holmium target through LLX using cation exchanger HDEHP. (author)

2001-02-07

355

Recovery of radioactive thallium isotopes from lead and bismuth targets irradiated by 1-GeV protons  

Energy Technology Data Exchange (ETDEWEB)

A simple highly efficient procedure has been developed for recovery of thallium radioisotopes from lead and bismuth targets irradiated by 1-GeV protons. The procedure is based on the use of extraction chromatography. The cross-sections have been determined for formation of {sup 200}Pb, {sup 201}Pb, {sup 202m}Pb, and {sup 203}Pb radioisotopes in targets from lead with natural isotopic composition, irradiated by 1-GeV protons.

1995-03-01

356

Recovery of radioactive thallium isotopes from lead and bismuth targets irradiated by 1-GeV protons  

International Nuclear Information System (INIS)

A simple highly efficient procedure has been developed for recovery of thallium radioisotopes from lead and bismuth targets irradiated by 1-GeV protons. The procedure is based on the use of extraction chromatography. The cross-sections have been determined for formation of "2"0"0Pb, "2"0"1Pb, "2"0"2"mPb, and "2"0"3Pb radioisotopes in targets from lead with natural isotopic composition, irradiated by 1-GeV protons.

357

Preliminary Study of Plasma Stream Interaction with Tungsten Target within RPI-IBIS Facility  

International Nuclear Information System (INIS)

The paper presents results of experimental research on the interaction of a pulsed plasma-ion stream with a tungsten (W) target. The pulsed hydrogen plasma was produced within the RPI-IBIS (Multi-Rod Plasma Injector) facility at IPJ in Swierk. Measurements were carried out by means of optical spectroscopy and corpuscular diagnostic techniques. For experiments with the W-target the operational conditions (so-called PID mode) were chosen when a clean hydrogen plasma stream was generated. Attention was paid to the identification of WI and WII spectral lines.

2006-01-01

358

Modified-VSIMM algorithm with an application to the naval fire control technology  

British Library Electronic Table of Contents (United Kingdom)

A modified variable structure interacting multiple model (M-VSIMM) estimator for complex hybrid maneuver target tracking is presented. The M-VSIMM could potentially be applied to fire control systems (FCS) used on warships. Target model groups were designed using 3D dimensional dynamic target models. Optimal model group selection logic was proposed, contrary to the activation and termination logic in the original VSIMM. The system will respond faster with optimal model group selection logic. After performing simulations, the tracking performances of the Kalman, ?-?(-?), VDIE, IMM and M-VSIMM filters were compared under various maneuvering conditions.

2011-01-01

359

Convoy electron production in polycrystalline and monocrystalline targets  

Energy Technology Data Exchange (ETDEWEB)

The velocity distribution of electrons ejected close to the forward direction by 0.8-2 MeV/A ions traversing various solid targets, including a Au monocrystal, is measured in coincidence with emerging charge-selected ions. The velocity spectrum is observed to be independent of outgoing projectile velocity and charge state for polycrystalline targets. Measurements on the Au crystal under channeling conditions show dependences on final charge state, and are tentatively explained by assuming that the main contribution to the production yield comes from the non-channeled fraction of the ions. A simple model for the creation of the forward-ejected electrons is proposed, which accounts for most of the experimental findings.

1980-01-01

360

Computer-assisted rotation and multiple stationary irradiation technique  

International Nuclear Information System (INIS)

A computer-assisted rotation and stationary conformation radiotherapy system with overrunning multileaf collimators has been developed. This system can produce any shape of target volume, including a number of target areas outside the axis of the rotation, regardless of the location of the axis at 360"0 rotation irradiation. In addition, by changing the dose rate and deleting a partial region within a field, multiple stationary irradiation can produce more homogeneous target volumes - thus avoiding excessive irradiation to critical organs - than the rotation technique. (orig.).

361

Centroid and Envelope Dynamics of High-intensity Charged Particle Beams in an External Focusing Lattice and Oscillating Wobbler  

Energy Technology Data Exchange (ETDEWEB)

The centroid and envelope dynamics of a high-intensity charged particle beam are investigated as a beam smoothing technique to achieve uniform illumination over a suitably chosen region of the target for applications to ion-beam-driven high energy density physics and heavy ion fusion. The motion of the beam centroid projected onto the target follows a smooth pattern to achieve the desired illumination, for improved stability properties during the beam-target interaction. The centroid dynamics is controlled by an oscillating "wobbler", a set of electrically-biased plates driven by RF voltage. __________________________________________________

2010-04-28

362

A search for. nu. sub e appearance from stopped. pi. sup + and. mu. sup + decay at LAMPF (Los Alamos Meson Physics Facility)  

Energy Technology Data Exchange (ETDEWEB)

We report on a recent search for {bar {nu}}{sub e} appearance from stopped {pi}{sup +} {yields} {mu}{sup +}{nu}{sub {mu}} and {mu}{sup +} {yields} e{sup +}{nu}{sub e}{bar {nu}}{sub {mu}} decay made by the LAMPF experiment E645. The appearance of {bar {nu}}{sub e} may occur from {bar {nu}}{sub {mu}} {yields} {bar {nu}}{sub e}, {nu}{sub e} {yields} {bar {nu}}{sub eL}, or {nu}{sub {mu}} {yields} {bar {nu}}{sub eL} oscillations. Appearance may also occur from rare {mu}{sup +} {yields} e{sup +}{bar {nu}}{sub e}{nu}{sub {mu}} decay, which is allowed by a multiplicative lepton charge conservation law. The neutrino energies range from E{sub {nu}} = 0 to 52.8MeV. The neutrino detector, which is located 26.1 meters from the neutrino source, consists of a segmented liquid scintillator and proportional drift tube central detector surrounded by both active and passive shielding. The central detector detects {bar {nu}}{sub e} through the {bar {nu}}{sub e}p {yields} ne{sup +} Charge Current (CC) ...

1990-01-01

363

Yields of Residual Nuclei from Proton-Irradiated Materials  

International Science & Technology Center (ISTC)

Experimental and Theoretical Study of the Residual Nuclide Production in 40-2600 MeV Proton-Irradiated Thin Targets of ADS Basic Materials

364

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates?  

UK PubMed Central (United Kingdom)

Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes...Full Text Available

2008-06-01

366

The influence of target backing on ion-beam electron spectra  

International Nuclear Information System (INIS)

Several different aspects of the influence of the target backing on in-beam electron spectra following compound nuclear reactions induced by accelerated ions at tandem energies irradiating backed targets are discussed in detail. This discussion is illustrated by a few typical examples, such as "1"2C"5"+ and "3"1P"1"0"+ beams at 4 MeV/u bombarding Sn(+Be), Sn(+Au), Pb(+C) backed targets. Moreover, the relative influence of electron backscattering, electron Doppler shift and Doppler broadening as well as #delta#-electron emission on the low energy electron spectra (E_e#<=#100 keV) obtained under such conditions are investigated in the frame of the available experimental data. (orig.).

367

The importance of an accurate target wave function in variational calculations for (e^{+}-H_{2}) scattering  

CERN Document Server

Using the complex Kohn method, we have calculated variational values of phase shifts and the annihilation parameter, Z_{eff}, for the elastic scattering of positrons by molecular hydrogen. Our results are sensitive to small changes in the accuracy of the wave function representing the target hydrogen molecule. We have developed a systematic approach to demonstrate that, at low positron energies, there are particular forms of the Kohn trial wave function for which the results of variational calculations are not reliable, even when the target wave function accounts for as much as 96.8% of the correlation energy of H_{2}. We find that reliable results can be recovered if our calculations are extended to admit more sophisticated target wave functions accounting for 99.7% of the correlation energy. Remaining discrepancies between theory and experiment are briefly discussed.

2008-01-01

368

The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance  

UK PubMed Central (United Kingdom)

Axon outgrowth and guidance to the proper target requires the coordination of filamentous (F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape change and locomotion....Full Text Available

369

The Development of New Methods for Solving the Target ...  

Science.gov (United States)

... and 7 survey papers. On the inverse Stefan problem he wrote 3 research papers and 1 survey paper. The papers on inverse ...

1984-07-18

370

Target space duality I: general theory  

Energy Technology Data Exchange (ETDEWEB)

We develop a systematic framework for studying target space duality at the classical level. We show that target space duality between manifolds M and M-tilde arises because of the existence of a very special symplectic manifold. This manifold locally looks like MxM-tilde and admits a double fibration. We analyze the local geometric requirements necessary for target space duality and prove that both manifolds must admit flat orthogonal connections. We show how abelian duality, nonabelian duality and Poisson-Lie duality are all special cases of a more general framework. As an example we exhibit new (nonlinear) dualities in the case M=M-tilde=R{sup n}.

2000-09-25

371

Studies of relativistic heavy ion collisions at the AGS (Experiment 814)  

Energy Technology Data Exchange (ETDEWEB)

This report discusses the experimental setup of experiment 814 at Brookhaven AGS. This experiment involves the collision of silicon ions with target nuclei. The detector systems are discussed primarily. (LSP)

1990-01-01

372

Smoking and reproduction: The oviduct as a target of cigarette smoke  

UK PubMed Central (United Kingdom)

The oviduct is an exquisitely designed organ that functions in picking-up ovulated oocytes, transporting gametes in opposite directions to the site of fertilization, providing a suitable environment...Full Text Available

373

Simultaneous recognition and segmentation of cells: application in C.elegans  

UK PubMed Central (United Kingdom)

Motivation: Automatic recognition of cell identities is critical for quantitative measurement, targeting and manipulation of cells of model animals at single-cell resolution. It has been...Full Text Available

2011-10-15

374

Principles of antibody therapy.  

UK PubMed Central (United Kingdom)

The success of monoclonal antibodies in clinical practice is dependent on good design. Finding a suitable target is the most important part as other properties of the antibody can be altered by genetic...Full Text Available

1992-12-05

375

Novel Cytotoxic Vectors Based on Adeno-Associated Virus  

Wastenet

positive primary PymT breast cancer cells in primary co-cultured tumor tissue, suggesting target specificity of

376

Knowledge-Based Identification of the ERK2/STAT3 Signal Pathway as a Therapeutic Target for Type 2 Diabetes and Drug Discovery  

British Library Electronic Table of Contents (United Kingdom)

Many existing agents for diabetes therapy are unable to restore or maintain normal glucose homeostasis or prevent the eventual emergence of hyperglycemia-related complication. Therefore, agents based on novel mechanisms are sought to complement and extend the current therapeutic approaches. Based on the initial paper research, we focused on active STAT3 as an attractive pharmacological target for type 2 diabetes. The subsequent text mining with a unique query to identify suppressors but not activators of STAT3 revealed the ERK2/STAT3 pathway as a novel diabetes target. The description of ERK2 inhibitors as diabetes target had not been found in our text mining research at present. The mechanism-based peptide inhibitor for ERK2 was identified using the knowledge of the KIM sequence, which ha...

2011-01-01

377

Johnson News - NASA  

Science.gov (United States)

Nov 21, 2003... for the European Space Agency's Automated Transport Vehicle, a new, uncrewed station cargo vehicle targeted for launch late next year. ...

378

Ion channels, transporters, and pumps as targets for heart failure  

UK PubMed Central (United Kingdom)

Congestive heart failure (CHF) is a leading cause of morbidity and mortality. CHF is marked by atrial and ventricular enlargement and reduced cardiac contractility, as well as an association...Full Text Available

2009-10-01

379

Imaging immune response in vivo  

UK PubMed Central (United Kingdom)

PurposeClinical trials have commenced to evaluate the feasibility of targeting malignant gliomas with genetically engineered cytolytic T-cells (CTLs) delivered directly...Full Text Available

2008-06-15

380

Heat shock proteins as emerging therapeutic targets  

UK PubMed Central (United Kingdom)

Chaperones (stress proteins) are essential proteins to help the formation and maintenance of the proper conformation of other proteins and to promote cell survival after a large variety of environmental...Full Text Available

2005-11-01

381

Genomics of human longevity  

UK PubMed Central (United Kingdom)

In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences...Full Text Available

2011-01-12

382

Gene therapy for ocular diseases  

UK PubMed Central (United Kingdom)

The eye is an easily accessible, highly compartmentalised and immune-privileged organ that offers unique advantages as a gene therapy target. Significant advancements have been made in understanding...Full Text Available

2011-05-01

383

GAVA: Spectral Simulation for In Vivo MRS Applications  

UK PubMed Central (United Kingdom)

An application that provides a flexible and easy to use interface to the GAMMA spectral simulation package is described that is targeted at investigations using in vivo MR spectroscopic methods....Full Text Available

2007-04-01

384

Evaluation of phenylpiperazines as targeting agents for neuroblastoma.  

UK PubMed Central (United Kingdom)

The potential of radiolabelled phenylpiperazines as agents for the detection and therapy of tumours of neural crest origin was evaluated by in vitro pharmacological studies with human neuroblastoma...Full Text Available

1996-09-01

385

Effects of voicing in the recognition of concurrent syllables (L)a)  

UK PubMed Central (United Kingdom)

This letter reports a study designed to measure the benefits of voicing in the recognition of concurrent syllables. The target and distracter syllables were either voiced or whispered, producing...Full Text Available

2009-12-01

386

Dynamic clamp with StdpC software  

UK PubMed Central (United Kingdom)

Dynamic clamp is a powerful method that allows the introduction of artificial electrical components into target cells to simulate ionic conductances and synaptic inputs. This method is based...Full Text Available

2011-03-01

387

Dynamic Weapon-Target Assignment Problems with ...  

Science.gov (United States)

... defense's weapons are Space-based kinetic-kill vehicles ... I ti I obtained by dividing the weapons as ... of the optimal weapon-arge assigntments and ...

1988-06-01

388

Cooperative Charging Effects of Fibers From Electrospinning ...  

Science.gov (United States)

... In the Proceedings of INTC 2003, we studied charging effects on target coverage during electrospinning (16). ... of Fibers from Electrospinning of ...

2005-01-05

389

Comparative genomics of insect juvenile hormone biosynthesis?  

UK PubMed Central (United Kingdom)

The biosynthesis of insect juvenile hormone (JH) and its neuroendocrine control are attractive targets for chemical control of insect pests and vectors of disease. To facilitate the molecular...Full Text Available

2006-04-01

390

Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration  

UK PubMed Central (United Kingdom)

The pleiotropic actions of neuromodulators on pre- and postsynaptic targets present challenges to disentangling the mechanisms underlying regulation of synaptic transmission. Within the striatum,...Full Text Available

2009-09-01

391

Bacterial flora-typing with targeted, chip-based Pyrosequencing  

UK PubMed Central (United Kingdom)

BackgroundThe metagenomic analysis of microbial communities holds the potential to improve our understanding of the role of microbes in clinical conditions. Recent, dramatic improvements...Full Text Available

392

Approaches to the evaluation of chemical-induced immunotoxicity.  

UK PubMed Central (United Kingdom)

The immune system plays a crucial role in maintaining health; however, accumulating evidence indicates that this system can be the target for immunotoxic effects caused by a variety of chemicals including...Full Text Available

1995-12-01

393

An Extended Kalman Filter for Use in a Shared Aperture ...  

Science.gov (United States)

... used to track a point source target ... A one sigma tracking error of .2 ... LOOKING INFRARED SYSTEMS, *KALMAN FILTERING, SIGNAL PROCESSING ...

1978-12-01

394

A comprehensive assessment of N-terminal signal peptides prediction methods  

UK PubMed Central (United Kingdom)

BackgroundAmino-terminal signal peptides (SPs) are short regions that guide the targeting of secretory proteins to the correct subcellular compartments in the cell. They are cleaved...Full Text Available

395

Phenomenological realism, superconductivity and quantum mechanics  

Energy Technology Data Exchange (ETDEWEB)

The central aim of this thesis is to present a new kind of realism that is driven not from the traditional realism/anti-realism debate but from the practice of physicists. The usual debate focuses on discussions about the truth of theories and their fit with nature, while the real practices of the scientists are forgotten. The position I shall defend is called 'phenomenological realism': theories are merely tools to construct other theories and models, including phenomenological models; phenomenological models are the vehicles of representation. The realist doctrine was recently undermined by the argument from the pessimistic meta-induction, also known as the argument from scientific revolutions. I argue that phenomenological realism is a new kind of scientific realism which can overcome the problem generated by the argument from scientific revolutions, and which depend on the scientific practice. The realist tried to overcome ...

1998-07-01

396

X-winds in Action  

CERN Document Server

The interaction of accretion disks with the magnetospheres of young stars can produce X-winds and funnel flows. With the assumption of axial symmetry and steady state flow, the problem can be formulated in terms of quantities that are conserved along streamlines, such as the Bernoulli integral (BI), plus a partial differential equation (PDE), called the Grad-Shafranov equation (GSE), that governs the distribution of streamlines in the meridional plane. The GSE plus BI yields a PDE of mixed type, elliptic before critical surfaces where the flow speed equals certain characteristic wave speeds are crossed and hyperbolic afterward. The computational difficulties are exacerbated by the locations of the critical surfaces not being known in advance. To overcome these obstacles, we consider a variational principle by which the GSE can be attacked by extremizing an action integral, with all other conserved quantities of the problem explicitly included as part of the overall ...

2007-01-01

397

Working with activity theory: Context, technology, and information behavior  

British Library Electronic Table of Contents (United Kingdom)

Abstract Over the last 7 years, the AIMTech Research Group in the University of Leeds has used cultural-historical activity theory (CHAT) to inform a range of research activities in the fields of information behavior and information systems. In this article, we identify certain openings and theoretical challenges in the field of information behavior, which sparked our initial interest in CHAT: context, technology, and the link between practice and policy. We demonstrate the relevance of CHAT in studying information behavior and addressing the identified openings and argue that by providing a framework and hierarchy of activity-action-operation and semantic tools, CHAT is able to overcome many of the uncertainties concerning information behavior research. In particular, CHAT provides resear...

2011-01-01

398

Uncertainty, rationality and cooperation in the context of climate change  

British Library Electronic Table of Contents (United Kingdom)

Climate change represents the largest social dilemma humans have ever faced, where individual actors maximise their personal gain by emitting greenhouse gases into the atmosphere even though this is detrimental to the collective global good. Cooperation on a global scale is urgently required if we are to overcome this problem. However, this is difficult to achieve because cooperators pay the cost of reducing emissions while any benefits are shared between cooperators and free-riders alike. In a risk-free, rational world cooperative behaviour can be promoted through mechanisms that increase the benefit of cooperating relative to free-riding, such as rewards or sanctions. In reality, however, outcomes are seldom certain and humans rarely behave rationally when confronted with risky prospects...

2011-01-01

399

The use of WASP model for planning the Portuguese electrical generating system: overcoming some difficulties  

International Nuclear Information System (INIS)

The paper discusses the methodology used at Electricidade de Portugal (EDP) in planning its electric power system. In particular, it considers a description of the methodology used by EDP for a more accurate definition of the input data required to characterize hydroelectric plants and the evaluation of their impact on an optimal long-term expansion plan. In addition, the paper describes an analysis of the results of studies, both with WASP-II and WASP-III, with and without pumped storage plants, respectively. Finally, the paper details the use of VALOR AGUA, in conjunction with WASP, for a better simulation of the hydroelectric system and which also permits to solve other problems closely connected such as the calculation of marginal production costs. (author).

1986-02-01

400

Studies with a generalized neuron based Pss on a multi-machine power system  

International Nuclear Information System (INIS)

An artificial neural network can be used as an intelligent controller to control non-linear, dynamic system through learning. It can easily accommodate non-linearities and time dependencies. Most common multi-layer feed-forward neural networks have drawbacks of large number of neurons and hidden layers required to deal with complex problems and require large training time. To overcome these drawbacks, a generalized neuron based non-linear controller has been developed and illustrated as a power system stabilizer. Studies on a five-machine power system show that the proposed controller can significantly improve the dynamic performance and provide good damping of the power system over a wide operating range.

2004-07-01

401

Structural material trends in future power plants  

Energy Technology Data Exchange (ETDEWEB)

Future power plants will be more fuel efficient, environmentally benign, and economical than current power plants. A high performance power system (HIPPS), based on a coal-fired combined cycle, is currently being developed. The corrosion and temperature-strength properties of currently available metallic materials limit the maximum efficiency of this cycle. Recently, ceramic matrix composites have shown promise in overcoming the design limitations on the future power plants. In particular, the high-temperature, and corrosion and erosion resistant properties of continuous fiber ceramic composites (CFCCs) will allow engineers to design high-temperature heat exchangers, cyclone vortex finder tubes, and other components. Research being performed to evaluate candidate materials for use in future power plants is discussed.

2000-07-01

402

Special eddy current probes for heat exchanger inspection  

International Nuclear Information System (INIS)

Until a decade ago, only the differential bobbin type eddy current probe was considered necessary for reliable heat exchanger tube inspection. The introduction of different tube materials, manufacturing processes and a variety of service induced failures has greatly increased the demands of eddy current testing. Optimized probe designs enhanced by improved instrumentation can help satisfy some of these demands. Some of the more difficult inspection problems are detection of circumferential cracks, fretting wear under non-ferromagnetic support plates and shallow internal defects. Reliable detection and sizing of such defects is often made more difficult by the fact they frequently occur in defect prone regions such as under tubesheets or support plates and in transition regions of finned tubes. Probe designs effective in overcoming these difficulties exist. This paper describes a number of such probes and their performance.

1986-11-17

403

Single cylinder testing of a high-pressure electronic pilot fuel injector for low NO sub x emission dual fuel engines. Part 1; Baseline, feasibility, and comparative testing  

Energy Technology Data Exchange (ETDEWEB)

This paper reports on current dual fuel engines utilizing standard mechanical (Bosch type) fuel injection systems set to 5--6 percent pilot delivery that do not appear capable of reducing NO{sub x} emissions much below the current minimum of 4 g/bhp-h without incurring substantial penalties in efficiency and operability. A prototype Electronic Pilot Fuel Injector (EPFI) was designed that overcomes the shortcomings of the mechanical injection system, consistently delivering 3 percent or less pilot at pressures as high as 20,000 psi. The EPFI was installed and tested in one cylinder of a standard production dual fuel engine operating at a waste water treatment facility.

1990-07-01

404

Sheathed cold-formed steel housing: A seismic design procedure  

British Library Electronic Table of Contents (United Kingdom)

Nowadays, different research teams are engaged on experimental and theoretical studies having as main aim the evaluation of seismic performance of sheathed cold-formed steel frame structures. Although a relatively large number of experimental and theoretical studies are available, the development of useful tools for the seismic design should be improved. As an attempt to overcome this lack, this paper aims to present a structural design procedure that allows, through the definition of three design nomographs, the screw spacing and all the shear walls components to be obtained on the basis of linear dynamic or nonlinear static seismic analysis. In addition, a procedure for the prediction of the whole pushover response curve of sheathed cold-formed steel shear walls, which can be advantageou...

2009-01-01

405

Seismic retrofitting of nonductile beam-column sub-assemblage using FRP wrapping and steel plate jacketing  

British Library Electronic Table of Contents (United Kingdom)

The paper discusses the aspects of repair and retrofitting technique adopted for a damaged reinforced concrete beam-column joint specimen under cyclic loading. A specimen designed based on Indian Standard specifications with consideration of seismic load but without adopting ductile detailing (NonDuctile) was investigated under reverse cyclic loading. Then, the damaged nonductile specimen was repaired with epoxy mortar and grouted using low viscous polymer, and retrofitted using fiber reinforced plastic (FRP) wrapping in beam and column components and steel plate jacketing in joint region. The experimental results showed that the retrofitted specimen not only regained its original strength and stiffness but also has overcome the deficiencies of nonductile detailing. The present study shows...

2011-01-01

406

Seductions of Risk and School Cyberspace  

Science.gov (United States)

Drawing upon the cultural risk perspective and writings on risk taking, this paper seeks to develop ideas relating to the effective use of school cyberspace. It is argued that some individuals respond to exaggerated, yet seductive, discourses of online risks by over-blocking, unreasonably restricting students' Internet activity. At the same time, there are sensible, even compelling, motivations for teachers as well as students to use the school Internet to engage in low-level risk taking, fostering excitement, identity construction and networked media literacy. Connecting these seductive pushes and pulls of risk it is ultimately maintained that the fostering of trust through open communication is key in overcoming over-blocking whilst allowing for greater educational gains, realised in part through certain types of low-level risk taking in school cyberspace.

2009-12-01

407

Rethinking development assistance for wind power  

Energy Technology Data Exchange (ETDEWEB)

Electricity generation from wind turbines is now cost competitive for grid and off-grid applications in many developing regions, and close to competitive in others. Wind resources could generate thousands of megawatts of badly-needed power in Asia, North Africa, and Latin America. Barriers to penetrating power generation markets remain, however, including unequal access to investment capital, energy price and other market distortions, and often weak institutions for commercializing new technologies. Recognizing the potential economic and environmental benefits of wind power, bilateral and multilateral assistance organizations have for several years offered financial and technical assistance to promote its diffusion. Based on this experience and assistance for other renewable electric technologies, lessons and recommendations can be drawn regarding how assistance could more effectively overcome persistent market and policy barriers, especially in light of the ...

1995-12-31

408

Resonant inelastic soft x-ray scattering of CdS: a two-dimensional electronic structure map approach  

Energy Technology Data Exchange (ETDEWEB)

Resonant inelastic x-ray scattering (RIXS) with soft x-rays is uniquely suited to study the elec-tronic structure of a variety of materials, but is currently limited by low (fluorescence yield) count rates. This limitation is overcome with a new high-transmission spectrometer that allows to measure soft x-ray RIXS"maps." The S L2,3 RIXS map of CdS is discussed and compared with density functional calculations. The map allows the extraction of decay channel-specific"absorp-tion spectra," giving detailed insight into the wave functions of occupied and unoccupied elec-tronic states.

2008-09-24

409

Residential proximity to high voltage transmission lines and depressive symptomatology  

Energy Technology Data Exchange (ETDEWEB)

A number of epidemiological studies indicate an association between depression and proximity to high voltage transmission lines. These studies have been criticized, however, for using surrogate measures of electromagnetic fields (EMFs) and unstandardized measures of depression. In an effort to overcome these limitations, the Center for Epidemiological Studies Depression (CES-D) scale was administered to 152 women living either adjacent to a transmission line or one block away. Results indicate that homes adjacent to the transmission lines have an average EMF level of 4.86 milligauss at their front door and those one block away have an average of 0.68 milligauss. There was no significant difference in CES-D scores between the groups, controlling for demographic variables. There appeared to be an increase in other health effects, including cancer and miscarriages, but these findings were preliminary and need further investigation.

1992-01-01

410

Repair of floating offshore units using bonded fibre composite materials  

British Library Electronic Table of Contents (United Kingdom)

On ships, tankers and similar vessels structural defects such as cracks and corrosion damage are typically repaired by welding. However, welding is unwanted hotwork on floating offshore units (FOUs) such as floating, production, storage and offloading (FPSO) and floating, storage and offloading (FSO) vessels because it requires shutdown of parts of the vessel thus resulting in expensive production delays. Bonded fibre composite material patch repairs can be used as an alternative to overcome the hazards of hotwork associated with welding. The patches are bonded over the defect and the integrity of the original structure is hence restored. The patch repair technology can also be utilised to provide upgrades, such as life extensions and higher design requirements. A recommended practice (RP)...

2009-01-01

411

Reducing barriers to energy efficiency in the German higher education sector. Final report  

Energy Technology Data Exchange (ETDEWEB)

This report describes the empirical research into barriers to energy efficiency in the German higher education (HE) sector. It is one of nine such reports in the BARRIERS project. The report contains description and analysis of six case studies of energy management in German universities. The results are analysed using the theoretical framework developed for the BARRIERS project (Sorrell et al., 2000). The report also provides brief recommendations on how these barriers to the rational use of energy (RUE) may be overcome and how energy efficiency within the sector may be improved. The results of the study for the higher education sector in Germany are summarised in this executive summary under the following headings: - Characterising the higher education sector; - Case studies of energy management in the German higher education sector; - Evidence of barriers in the German higher education sector; - The role of energy service companies in the higher education ...

2000-12-01

412

Recognizing limitations in eddy current testing  

International Nuclear Information System (INIS)

This paper addresses known limitations and constraints in eddy current nondestructive testing. Incomplete appreciation for eddy current limitations is believed to have contributed to both under-utilization and misapplication of the technique. Neither situation need arise if known limitations are recognized. Some, such as the skin depth effect, are inherent to electromagnetic test methods and define the role of eddy current testing. Others can be overcome with available technology such as surface probes to find circumferential cracks in tubes and magnetic saturation of ferromagnetic alloys to eliminate permeability effects. The variables responsible for limitations in eddy current testing are discussed and where alternative approaches exist, these are presented. Areas with potential for further research and development are also identified.

1993-11-01

413

Pumping up the volume  

Energy Technology Data Exchange (ETDEWEB)

Currently the construction of small-scale hydroelectric and pumped storage plants is booming in the USA. The technology is attractive because of its relatively cheap construction methods and operation. Electric utilities are seeing it as a viable source of peaking power and a means of system regulation. Two schemes are described. One is a high-head/small flow river project designed to generate 3.5 MW and is about to come on line having overcome tight environmental and commercial constraints. The second is a pumped-storage project using two man-made reservoirs with an average elevation difference of 1280 ft. It is deemed to be of minimum environmental impact construction and good physical characteristics. Completion is hoped for by 1995 and the plant will deliver 1000 MW. (UK)

1994-04-01

414

Proposed roadmap for overcoming legal and financial obstacles to carbon capture and sequestration  

Energy Technology Data Exchange (ETDEWEB)

Many existing proposals either lack sufficient concreteness to make carbon capture and geological sequestration (CCGS) operational or fail to focus on a comprehensive, long term framework for its regulation, thus failing to account adequately for the urgency of the issue, the need to develop immediate experience with large scale demonstration projects, or the financial and other incentives required to launch early demonstration projects. We aim to help fill this void by proposing a roadmap to commercial deployment of CCGS in the United States.This roadmap focuses on the legal and financial incentives necessary for rapid demonstration of geological sequestration in the absence of national restrictions on CO2 emissions. It weaves together existing federal programs and financing opportunities into a set of recommendations for achieving commercial viability of geological sequestration.

2009-03-01

415

Plasma density ramp for relativistic self-focusing of an intense laser  

International Nuclear Information System (INIS)

It is known that a high-power laser propagating through an underdense plasma can acquire a minimum spot size due to relativistic self-focusing. Beyond the focus, the nonlinear refraction starts weakening, and the spot size of the laser increases, showing periodic self-focusing/ defocusing behavior with the distance of propagation. To overcome the defocusing, we propose the introduction of a localized upward plasma density ramp. In the presence of an upward ramp of plasma density, the laser beam obtains a minimum spot size and maintains it with only a mild ripple. For suitable parameters of the laser and the plasma, we have deduced conditions for the self-focusing. This kind of plasma density ramp may be observed in a gas-jet plasma experiment and resembles a plasma lens.

2007-05-01

416

PERFORMANCE-LIMITING DEFECTS IN CDZNTE DETECTORS.  

Energy Technology Data Exchange (ETDEWEB)

We studied the effects of small, <20 {micro}m, Te inclusions on the energy resolution of CdZnTe gamma-ray detectors using a highly collimated X-ray beam and gamma-rays, and modeled them via a simplified geometrical approach. Previous reports demonstrated that Te inclusions of about a few microns in diameter degraded the charge-transport properties and uniformity of CdZnTe detectors. The goal of this work was to understand the extent to which randomly distributed Te-rich inclusions affect the energy resolution of CZT detectors, and to define new steps to overcome their deleterious effects. We used a phenomenological model, which depends on several adjustable parameters, to reproduce the experimentally measured effects of inclusions on energy resolution. We also were able to hound the materials-related problem and predict the enhancement in performance expected by reducing the size and number of Te inclusions within the crystals.

2006-10-29

417

Optimization of products and processes in petrochemical industry through modifications in the existing agitation systems: Case studies; Otimizacao de processos/produtos da industria petroquimica atraves de modificacoes nos sistemas de agitacao existentes. Estudo de casos  

Energy Technology Data Exchange (ETDEWEB)

Nowadays, mixing is one of the most powerful tools for the process and products optimization in chemical process industries. The available technology can help in achieving almost any desired outcomes related to the process-side of the systems. This paper presents a practical methodology to improve existing agitation systems in order to overcome the constraints previously identified in the process. Well succeed real cases using this methodology in a petrochemical plant (Nitriflex S.A.) are presented. (author) 13 refs., 1 figs., 2 tabs.

1992-12-31

418

Nuclear techniques for measuring moisture content in soil profiles  

International Nuclear Information System (INIS)

The prevailing severe shortage of animal feed in most of the developing countries could, to a considerable extent, be overcome through improved range management, which includes introduction of high yielding drought-resistant forage crops, development of adequate water conservation measures, and as far as possible growing annual forage crops on part of the vast areas of arable land currently left fallow each year. Year round measurements are essential for a good understanding of soil water and nutrients dynamics, which allow for adequate evaluation of pasture management alternatives. The methods most commonly used for moisture measurements in soil profiles are discussed because such measurements are likely to form an essential part of any investigation aimed at increasing animal feed production through the development of adequate pasture management practices. (author).

419

Neurotoxicity and bony diseases caused by the continuous contamination with aluminum of solutions of renal dialysis  

International Nuclear Information System (INIS)

This article reviews the principal evidences about aluminum neurotoxicity in vitro, and some evidences in brain tissues of Alzheimer patients; and also show some studies realized with human that suffer renal deficiencies, dealing whit the principal osteodystrophy. The problem of analyzing low aluminum concentration in human fluids is overcome with very sensitive analytical methods as electrothermal atomic absorption spectrometry (ETAS) and voltammetric methods as Anodic Striping Voltammetry with complexing agents that easing adsorption over solid electrodes or mercury hanging drops. Is a vital question to know with accuracy the aluminum concentration in water used in hemodialysis or in fluids used in ambulatory peritoneal dialysis, as a first stage to prevent contamination by aluminum. So the prevention of contamination during sapling storage and analysis of biological fluids should be the first need and the sources of water used in renal dialysis keep be as clean ...

2001-01-01

420

Nanoscale calcium bismuth mixed oxide with enhanced photocatalytic performance under visible light  

British Library Electronic Table of Contents (United Kingdom)

The objective of materials research is the development of economical, safe and efficient synthesis routes that lead to the formation of a photocatalyst which is able to overcome performance problems related to particle size, crystallinity, or low surface area. Here, we report high-quality functional nanoparticles of calcium bismuth mixed oxide with 15nm nominal size corresponding to a specific surface area of 41m^2/g which were produced by single-step flame spray synthesis (FSS). The high temperature of the flame afforded creation of oxygen vacancies which were quantified by near edge X-ray absorption fine structure (NEXAFS) spectra. These two parameters, developed active surface area and created in the flame oxygen vacancies, allowed to enhance the photocatalytic activity of calcium bismu...

2010-01-01

421

NIR-emissive erbium-quinolinolate complexes  

British Library Electronic Table of Contents (United Kingdom)

Studies addressed to a deep understanding of the structure/property relationship on the near infrared (NIR)-emissive erbium-quinolinolate complexes, which are of interest for low-cost photonic systems, are reviewed. The role of the 8-quinolinolate ligand (Q), which studies also as sensitizer to overcome the weak absorptivity of lanthanide ion, is discussed. Synthetic and structural aspects are reported to revise the old assumption that these complexes are analogous in structure to AlQ3 and to point out the specificity of the lanthanide coordination chemistry. In fact depending on reaction conditions, species with high coordination numbers and differing for nuclearity and stoichiometry have been isolated and fully characterized. In some instances it has been shown that coordinated water mol...

2011-01-01

422

Multiple Reggeon exchange from summing QCD Feynman diagrams  

International Nuclear Information System (INIS)

Multiple Reggeon exchange supplies subleading logarithms that may be used to restore unitarity to the Low-Nussinov Pomeron, provided it can be proven that the sum of Feynman diagrams to all orders gives rise to such multiple Regge exchanges. This question cannot be easily tackled in the usual way except for very low-order diagrams, on account of delicate cancellations present in the sum which necessitate individual Feynman diagrams to be computed to subleading orders. Moreover, it is not clear that sums of high-order Feynman diagrams with complicated crisscrossing of lines can lead to factorization implied by the multi-Regge scenario. Both of these difficulties can be overcome by using the recently developed non-Abelian cut diagrams. We are then able to show that the sum of s-channel-ladder diagrams to all orders does lead to such multiple Reggeon exchanges. copyright 1997 The American Physical Society.

423

Multiobjective design of Work-In-Process buffer for scheduling repetitive building projects  

British Library Electronic Table of Contents (United Kingdom)

Variability in production is one of the largest factors that negatively impacts construction project performance. A common construction practice to protect production systems from variability is the use of buffers (Bf). Construction practitioners and researchers have proposed buffering approaches for different production situations, but these approaches have faced practical limitations in their application. A multiobjective analytic model (MAM) is proposed to develop a graphical solution for the design of Work-In-Process (WIP) Bf in order to overcome these practical limitations to Bf application, being demonstrated through the scheduling of repetitive building projects. Multiobjective analytic modeling is based on Simulation?Optimization (SO) modeling and Pareto Fronts concepts. Simulation...

2009-01-01

424

Multi-level energy analysis of emerging technologies: a case study in new materials for lithium ion batteries  

British Library Electronic Table of Contents (United Kingdom)

A range of new nanomaterials to replace the active materials in lithium ion batteries are currently being studied and employed in an attempt to overcome various performance limitations of previous technologies. Nanomaterial production and manufacturing techniques appear to fit into a general trend towards more energy intensive production methods for high-tech goods. This does not necessarily imply an increase in lifecycle energy use; artefacts that consume or transform energy during use could possibly regain this increased initial input via increased efficiency in use. In particular, this paper highlights that larger gains could be possible if the artefact in question allows a given service to be provided via an alternative and more efficient system entirely.The lifecycle energy efficienci...

2011-01-01

425

Monitoring noise-resonant effects in cancer growth influenced by spontaneous fluctuations and periodic treatment  

CERN Document Server

In the paper we investigate a mathematical model describing the growth of tumor in the presence of immune response of a host organism. The dynamics of tumour and immune cells is based on the generic Michaelis-Menten kinetics describing interaction and competition between the tumour and the immune system. The appropriate phenomenological equation modeling cell-mediated immune surveillance against cancer is of the predator-prey form and within a given choice of parameters exhibits bistability. Under the influence of spontaneous weak fluctuations, the model may be analyzed in terms of a stochastic differential equation bearing the form of an overdamped Langevin-like dynamics in the external quasi-potential represented by a double well. We analyze properties of the system within the range of parameters for which the potential wells are of the same depth and when the additional perturbation describing a periodic treatment is insufficient to overcome the barrier height ...

2007-01-01

426

Modeling of Valveless Micropumps  

British Library Electronic Table of Contents (United Kingdom)

There are two difficulties encountered in modeling valveless micropumps using lumped-element methods. The pressure loss coefficient for fluidic diodes used in valveless pumps to rectify flow depends on the flow direction. A problem arises in choosing the proper loss correlation because the flow direction is not known a priori. Another problem is the quadratic form of the equation for the flow through the fluidic diodes, which brings about multiple solutions. The above problems become even more serious in multi-chamber cases. They are overcome in this study by suitably formulating the flow resistance. In addition, the flow inertia is accounted for in the unsteady model. The steady and unsteady models are evaluated by comparing with CFD simulations, which also serve to illustrate the flow fi...

2009-01-01

427

Microstructure analysis of nanocrystalline powders by X-ray diffraction  

International Nuclear Information System (INIS)

The use of X-ray diffraction line profile analysis for the study of nanocrystalline powders is described. The fundamentals of the theory are presented in terms of crystallite/domain size, size distribution, lattice distortion, dislocations density and stacking faults. Line profile parameters and the methods of pattern fitting introduced to overcome the diffraction-line overlap problem are discussed. The approaches based of the integral breadth of the measured line profiles and the Fourier method are discussed. In addition, simplified approaches are also commented. Representative examples are selected to illustrate various cases of microstructure, such as nanomaterials with strain-free spherical nano crystallites, strain-free crystallites with anisotropic crystallite shape, anisotropic crystallites with microstrains and spherical crystallites with dislocation densities and crystallite size distributions. (author)

2001-09-23

428

Mapping soil organic matter using the topographic wetness index: A comparative study based on different flow-direction algorithms and kriging methods  

British Library Electronic Table of Contents (United Kingdom)

Terrain attributes derived from digital elevation models have been used widely for mapping soil organic matter (SOM). Among these attributes, the topographic wetness index (TWI), an index for quantitatively indicating the balance between water accumulation and drainage conditions at the local scale, has been shown to correlate with SOM. However, TWIs used in most studies are calculated using a single-flow-direction (SFD) algorithm, which assumes that all water from a grid cell flows into only one neighboring cell. This assumption is not always valid, especially in areas with low relief where movement of water may be divergent. To overcome this SFD limitation, a multiple-flow-direction (MFD) algorithm has been developed, which distributes flow from a grid cell to several downslope neighbors...

2010-01-01

429

Kinetic behavior of solid particle in chemical-looping combustion: suppressing carbon deposition in reduction  

Energy Technology Data Exchange (ETDEWEB)

In order to apply chemical-looping combustion to a practical power plant, carbon deposition on the solid particle is one of the key problems to be overcome. Six kinds of solid particles were examined to clarify the kinetic behavior of carbon deposition. The effects of the solid composition, feed gas composition, and reaction temperature on carbon deposition were investigated by thermogravimetrical reactor on the basis of NiO/YSZ particle. From the viewpoints of both reactivity and resistance against carbon deposition, the particle of NiO mixed with YSZ (i.e., yttria-stabilized zirconia) was found to be a good candidate for chemical-looping combustion. It has been observed that carbon deposition could be completely avoided with very low concentration of water vapor. By means of a proposed model, the condition that carbon deposition would be avoided was identified. 12 refs., 8 figs., 2 tabs.

1998-03-01

430

Hydrostatic extrusion of magnesium: process mechanics and performance  

Energy Technology Data Exchange (ETDEWEB)

Following the breakthrough for cast magnesium products, interest is now spreading to wrought applications - triggering a variety of technological questions. A major bottleneck in the manufacture of magnesium sections (profiles) by conventional hot extrusion is the low productivity, with extrusion speeds typically five to ten times lower than for comparable aluminium sections. This paper focuses on the use of hydrostatic extrusion as a means to overcome this problem. On the basis of an analytical model, it is clarified why and how process limits are affected by the process mechanics. Experimental work on the hydrostatic extrusion of the alloys M1A, ZM21 and AZ31 confirms that extrusion speed is indeed multiplied, whereas the resulting mechanical properties are similar to or better than those for conventional extrusions. (orig.)

2003-07-01

431

Gear fault identification and classification of singular value decomposition based on Hilbert-Huang transform  

British Library Electronic Table of Contents (United Kingdom)

An improved singular value decomposition method of gear fault identification based on Hilbert-Huang transform was proposed to overcome the problem of reconstructing a feature matrix of singular value decomposition. The method includes three steps. First, the instantaneous frequency and amplitude matrices were acquired by Hilbert-Huang transform from faulted gear signals. Second, after the matrices were decomposed by singular value decomposition, the defined distances of singular value vectors and the optimal threshold of the distance for classification were calculated. Third, the fault characteristics of a gearbox were identified and classified by the threshold of the distances. The result demonstrates that the proposed method effectively identifies the gear fault and can realize an automa...

2011-01-01

432

Gear fault detection using customized multiwavelet lifting schemes  

British Library Electronic Table of Contents (United Kingdom)

Fault symptoms of running gearboxes must be detected as early as possible to avoid serious accidents. Diverse advanced methods are developed for this challenging task. However, for multiwavelet transforms, the fixed basis functions independent of the input dynamic response signals will possibly reduce the accuracy of fault diagnosis. Meanwhile, for multiwavelet denoising technique, the universal threshold denoising tends to overkill important but weak features in gear fault diagnosis. To overcome the shortcoming, a novel method incorporating customized (i.e., signal-based) multiwavelet lifting schemes with sliding window denoising is proposed in this paper. On the basis of Hermite spline interpolation, various vector prediction and update operators with the desirable properties of biorthog...

2010-01-01

433

Fourier transform IR studies on the interaction of selected chemicals with isolated cuticles  

International Nuclear Information System (INIS)

It is known that the plant cuticle represents the first barrier that must be overcome by any chemical reaching the plant surface from the atmosphere before entering the plant. Because of the importance of the cuticle as a barrier to penetration of a wide variety of compounds, its morphology, chemistry, and permeability have been extensively studied. However, only limited information is available on the nature of functional chemical groups present and their interaction and role during the penetration process. The usefulness of in situ Fourier transform infrared spectroscopy studies in identifying functional groups present in isolated cuticles is described and their relationships to the structure of the cuticular membrane are discussed. Applications of infrared spectroscopy on the presence and role of phenolics in the cuticle structure and during the cuticle development, nitrogen oxide binding to isolated cuticles, and the interactions between selected chemical ...

434

Exploration of the hypothalamic?pituitary?adrenal function as a tool to evaluate animal welfare  

British Library Electronic Table of Contents (United Kingdom)

Measuring HPA axis activity is the standard approach to the study of stress and welfare in farm animals. Although the reference technique is the use of blood plasma to measure glucocorticoid hormones (cortisol or corticosterone), several alternative methods such as the measurement of corticosteroids in saliva, urine or faeces have been developed to overcome the stress induced by blood sampling itself. In chronic stress situations, as is frequently the case in studies about farm animal welfare, hormonal secretions are usually unchanged but dynamic testing allows the demonstration of functional changes at several levels of the system, including the sensitization of the adrenal cortex to ACTH and the resistance of the axis to feedback inhibition by corticosteroids (dexamethasone suppression t...

2007-01-01

435

Experimental compliance calibration for the mixed-mode bending (MMB) specimen  

Energy Technology Data Exchange (ETDEWEB)

A novel method to control the mixed-mode bending (MMB) specimen is presented. By maintaining a constant opening, or Mode 1, displacement rate, stable delamination growth is achieved for all mixed-mode ratios. A constant-opening displacement rate is achieved by attaching a second displacement transducer to the hinges of the specimen. The test machine is then controlled externally by the second displacement transducer. By achieving stable delamination growth and monitoring the opening displacement, an experimental compliance calibration may be derived for the Modes 1 and 2 parts. This new approach to control the test and determine the experimental compliance calibration, overcomes the potential inaccuracies of the previously used beam theory expressions to determine compliance and to separate the modal values of G.

1997-12-31

436

EEMD method and WNN for fault diagnosis of locomotive roller bearings  

British Library Electronic Table of Contents (United Kingdom)

The ensemble empirical mode decomposition (EEMD) can overcome the mode mixing problem of the empirical mode decomposition (EMD) and therefore provide more precise decomposition results. Wavelet neural network (WNN) possesses the advantages of both wavelet transform and artificial neural networks. This paper combines the merits of EEMD and WNN to propose an automated and effective fault diagnosis method of locomotive roller bearings. First, the vibration signals captured from the locomotive roller bearings are preprocessed by EEMD method and intrinsic mode functions (IMFs) are produced. Second, a kurtosis based method is presented and used to select the sensitive IMF. Third, time- and frequency-domain features are extracted from the sensitive IMF, its frequency spectrum and its envelope spe...

2011-01-01

437

E-Waste recycling: new algorithm for hyper spectral identification  

International Nuclear Information System (INIS)

Waste electrical and Electronic Equipment (WEEE) constitutes 4% of the municipal waste in Europe, being increased by 16-28% every five years. Nowadays, Europe produces 6,5 million tonnes of WEEE per year and currently 90% goes to landfill. WEEE waste is growing 3 times faster than municipal waste and this figure is expected to be increased up to 12 million tones by 2015. Applying a new technology to separate non-ferrous metal Waste from WEEE is the aim of this paper, by identifying multi-and hyper-spectral materials and inserting them in a recycling plant. This technology will overcome the shortcomings passed by current methods, which are unable to separate valuable materials very similar in colour, size or shape. For this reason, it is necessary to develop new algorithms able to distinguish among these materials and to face the timing requirements. (Author). 22 refs.

2010-01-01

438

Design, synthesis and evaluation of 2-deoxy-2-iodovinyl-branched carbohydrates as potential brain imaging agents  

International Nuclear Information System (INIS)

Radioiodinated carbohydrates such as 2-deoxy-2-iodo-D-glucose and 3-deoxy-3-iodo-D-glucose undergo facile chemical or in vivo deiodination which precludes their use as radiotracers of glucose metabolism in tissues. To overcome the problems resulting from in vivo deiodination, we explored the concept of stabilizing radioiodide on a model carbohydrate, (E)-C-3-iodovinyl-D-allose (10) as an iodovinyl moiety. This agent did not exhibit brain specificity but showed low in vivo deiodination which demonstrated for the first time that radioiodide can be stabilized on a carbohydrate. The goal of this study was to develop a deoxy-branched carbohydrate with radioiodide stabilized as a vinyliodide with the objective of achieving high brain uptake. 10 refs., 1 fig., 1 tab.

2007-01-01

439

Design, synthesis and evaluation of 2-deoxy-2-iodovinyl-branched carbohydrates as potential brain imaging agents  

International Nuclear Information System (INIS)

Radioiodinated carbohydrates such as 2-deoxy-2-iodo-D-glucose and 3-deoxy-3-iodo-D-glucose undergo facile chemical or in vivo deiodination which precludes their use as radiotracers of glucose metabolism in tissues. To overcome the problems resulting from in vivo deiodination, we explored the concept of stabilizing radioiodide on a model carbohydrate, (E)-C-3-iodovinyl-D-allose as an iodovinyl moiety. This agent did not exhibit brain specificity but showed low in vivo deiodination which demonstrated for the first time that radioiodide can be stabilized on a carbohydrate. The goal of this study was to develop a deoxy-branched carbohydrate with radioiodide stabilized as a vinyliodide with the objective of achieving high brain uptake. (author).

440

Design of power system stabilizer through state variable feedback  

Energy Technology Data Exchange (ETDEWEB)

When the transmission line is very long or the generator is operated at a power factor nearly equal to 1.0, the machine regulated by an automatic voltage regulator (AVR) cannot be operated stably due to poor dynamic stability. To overcome this difficulty, the so called power system stabilizer (PSS) is very useful, in that output power or rotor speed of the generator is used as a feedback signal. The primary obective of the PSS is to damp the swing of the generator as quickly as possible. A method is proposed for designing PSS which yields a given eigenvalue. In the second method, the use of a Heffron-Phillips model is discussed. Next, a detailed procedure for the proposed design method is presented. A generalized method of a PSS design based on Park's equation and matrix operation is proposed.

1980-05-01

441

Capturing the Daylight Dividend  

Energy Technology Data Exchange (ETDEWEB)

Capturing the Daylight Dividend conducted activities to build market demand for daylight as a means of improving indoor environmental quality, overcoming technological barriers to effective daylighting, and informing and assisting state and regional market transformation and resource acquisition program implementation efforts. The program clarified the benefits of daylight by examining whole building systems energy interactions between windows, lighting, heating, and air conditioning in daylit buildings, and daylighting's effect on the human circadian system and productivity. The project undertook work to advance photosensors, dimming systems, and ballasts, and provided technical training in specifying and operating daylighting controls in buildings. Future daylighting work is recommended in metric development, technology development, testing, training, education, and outreach.

2006-04-30

442

Bongs - a new fertilizer plant  

Energy Technology Data Exchange (ETDEWEB)

In an attempt to overcome inadequacies perceived in the approach to providing energy to village communities using the conventional Khadi and Village Industries Commission biogas plant as well as the Janata model, a biogas digester has been developed suitable for a farmer having only one hectare of land. The information on gas yields and other data from a variety of substrates in a laboratory digester are presented. The digester itself consists of a chamber underground into which the influent flows through a channel. Gas is collected in a dome which constitutes the upper part of the digestion chamber and is maintained under pressure by water. The dome can be made of any suitable material such as plastic, ferrocement and brick and mortar. The upper part of the chamber itself is exposed to sun light which enhances microbial growth. Water which surrounds the dome ensures a minimum of temperature variation. 3 references.

1981-01-01

443

Bimetallic Pt-Ag and Pd-Ag nanoparticles  

International Nuclear Information System (INIS)

We report studies of bimetallic nanoparticles with 15%-16% atomic crystal parameters size mismatch. The degree of alloying was probed in a 2-nm Pt core (smallest attainable core size) of Pt-Ag nanoparticles (completely immiscible in bulk) and 20-nm-diameter Pd-Ag nanowires (completely miscible in bulk). Particles were synthesized radiolytically, and depending on the initial parameters, they assume spherical or cylindrical (nanowire) morphologies. In all cases, the metals are seen to follow their bulk alloying characteristics. Pt and Ag segregate in both spherical and wire forms, which indicates that strain due to crystallographic mismatch overcomes the excess surface free energy in the small particles. The Pd-Ag nanowires alloy similar to previously reported spherical Pd-Ag particles of similar diameter and composition.

2005-05-01

444

Benefits and applications of modular hydroelectric pumped storage  

International Nuclear Information System (INIS)

This paper reports on hydroelectric pumped storage which is the only proven and most efficient technology available for energy storage. It is used by utilities to provide peak and intermediate power and to optimize overall system performance. Because of increased environmental and regulatory constraints, few acceptable sites, long schedules, and huge financial commitments, large conventional pumped storage plants, are now virtually impossible to build. As an alternative, small modular pumped storage, with project sizes ranging from 25 MW to 200 MW, was created to overcome the difficulties of conventional projects. The modular approach involves standardizing the elements of a pumped storage plant by utilizing specialized siting techniques and optimizing design, equipment, and construction. Compared with conventional pumped storage, the modular design can reduce cost and expedite schedule; reduce environmental concerns and permitting obstacles; and expand ...

1991-07-24

445

An effective approach to the problem of time: general features and examples  

CERN Document Server

The effective approach to quantum dynamics allows a reformulation of the Dirac quantization procedure for constrained systems in terms of an infinite-dimensional constrained system of classical type. For semiclassical approximations, the quantum constrained system can be truncated to finite size and solved by the reduced phase space or gauge-fixing methods. In particular, the classical feasibility of local internal times is directly generalized to quantum systems, overcoming the main difficulties associated with the general problem of time in the semiclassical realm. The key features of local internal times and the procedure of patching global solutions using overlapping intervals of local internal times are described and illustrated by two quantum mechanical examples. The choice of time is tantamount to a choice of gauge at the effective level and changing the clock is, therefore, equivalent to a gauge transformation. This article complements the conceptual ...

2010-01-01

446

Amorphization of Zr_6_0Al_1_5Ni_2_5 surface layers by laser processing for corrosion resistance  

International Nuclear Information System (INIS)

It is generally known that a number of metallic glasses have excellent corrosion resistance in a variety of chemically hostile environments. Consequently, the use of laser cladding to coat a massive crystalline material such as aluminium with a layer of a metallic glass has obvious advantages. In this paper, the authors will show that the formation of a predominantly amorphous layer of Zr_6_0Al_1_5NI_2_5 alloy by laser processing is possible, if the obstacles to amorphization are overcome. In addition, evidence of the excellent corrosion resistance of this alloy in a NaCl solution will be given. A comparative study of the corrosion behavior of this amorphous alloy with pure aluminium and Al-Cr alloy will be done, in order to complete previous studies of laser processed coatings of aluminum substrates.

447

AlGaInP visible vertical cavity surface emitting lasers operating with gain contributions from the [ital n]=2 quantum well transition  

Science.gov (United States)

We report the characteristics of visible vertical cavity surface emitting laser diodes. Wafers are grown such that the Fabry--Perot resonance wavelength changes with position from 690 to 620 nm, overlapping to varying degrees with the [ital n]=1 and [ital n]=2 quantum well gain peaks at [similar to]670 and 650 nm. Gain guided devices are tested across the entire wafer, and pulsed room temperature lasing is observed from 634.6 to 663.2 nm. Our results suggest that gain contributions from the second quantized state are required to overcome high cavity losses in order to achieve lasing.

1993-12-20

448

Advances in the development of an AlGaAs/GaAs cascade solar cell using a patterned germanium tunnel interconnect  

Energy Technology Data Exchange (ETDEWEB)

In this paper, we discuss various aspects of the development of an inverted-grown AlGaAs/GaAs cascade solar cell incorporating a patterned germanium tunnel junction. Topics include the development of the Al{sub 0.37}Ga{sub 0.63}As top cell, the growth of the GaAs bottom cell over the patterned germanium tunnel junction, and a technique for selective removal of thin AlGaAs/GaAs heterostructures after lattice-matched growth on germanium substrates. The problems to be overcome for the achievement of around 30% efficiencies in the AlGaAs/GaAs cascade cell under concentrator applications are also discussed. (orig.).

1991-05-01

449

Ability of a solid state fermentation technique to significantly minimize catabolic repression of. alpha. -amylase production by Bacillus licheniformis M27  

Energy Technology Data Exchange (ETDEWEB)

The production of {alpha}-amylase by Bacillus licheniformis M27 in submerged fermentation was completely inhibited due to catabolic repression in medium containing 1% glucose. In contrast, the enzyme production in a solid state fermentation system was 19,550 units/ml extract even when the medium contained 15% glucose. The peak in enzyme titre was, however, shifted from 48 to 72 h. The ability of the solid state fermentation system to significantly overcome catabolic repression was not known earlier and is probably conferred by various physico-chemical factors and culture conditions specific to the system. (orig.).

1991-08-01

450

A study on the power system stabilizer using discrete-time adaptive sliding mode control  

Energy Technology Data Exchange (ETDEWEB)

In this paper the newly developed discrete-time adaptive sliding mode control method is proposed and applied to the power system stabilization problem. In contrast to the conventional continuous-time sliding mode controller, the proposed method is developed in the discrete-time domain and based on the input/output measurements instead of the continuous-time and the full-states feedback, respectively. Because the proposed control method has the adaptivity property in addition to the natural robustness property of the sliding mode control, it is possible to design the power system stabilizer which can overcome both the minor variations of the parameters of the power system and the diverse operating conditions and faults of the power system. Mathematical proof and the various computer simulations are done to verify the performance and stability of the proposed method. (author). 14 refs., 12 figs., 1 tab.

1996-02-01

451

A neural network based adaptive sliding mode controller: Application to a power system stabilizer  

Energy Technology Data Exchange (ETDEWEB)

In this paper, a neural networks (NN) based adaptive sliding mode controller (SMC) is introduced. The selection of SMC feedback gains is normally based on one operating point and thus the performance of the controller away from the design operating point is, of necessity, a compromise. The adaptive SMC is proposed to overcome the limitations imposed on the effectiveness of the SMC under different operating conditions. Neural networks are used for online prediction of the optimal SMC gains when the operating point changes. The proposed method has been applied to a power system stabilizer (PSS) of a single machine power system. Simulation results are included to demonstrate the performance of the proposed control scheme.

2011-02-15

452

A neural network based adaptive sliding mode controller: Application to a power system stabilizer  

International Nuclear Information System (INIS)

In this paper, a neural networks (NN) based adaptive sliding mode controller (SMC) is introduced. The selection of SMC feedback gains is normally based on one operating point and thus the performance of the controller away from the design operating point is, of necessity, a compromise. The adaptive SMC is proposed to overcome the limitations imposed on the effectiveness of the SMC under different operating conditions. Neural networks are used for online prediction of the optimal SMC gains when the operating point changes. The proposed method has been applied to a power system stabilizer (PSS) of a single machine power system. Simulation results are included to demonstrate the performance of the proposed control scheme.

2011-02-01

453

A multi-objective framework for dynamic transmission expansion planning in competitive electricity market  

Energy Technology Data Exchange (ETDEWEB)

Restructuring of power system has changed the traditional planning objectives and introduced challenges in the field of Transmission Expansion Planning (TEP). Due to these changes, new approaches and criteria are needed for transmission planning in deregulated environment. Therefore, in this paper, a dynamic expansion methodology is presented using a multi-objective optimization framework. Investment cost, congestion cost and reliability are considered in the optimization as three objectives. To overcome the difficulties in solving the non-convex and mixed integer nature of the optimization problems, a Non-Dominated Sorting Genetic Algorithm (NSGA II) approach is used followed by a fuzzy decision making analysis to obtain the final optimal solution. The planning methodology has been demonstrated on the IEEE 24-bus test system and north-east of Iran national 400 kV transmission grid to show the feasibility and capabilities of the proposed algorithm in electricity ...

2010-10-15

454

A calculation method of running range of electric vehicle with battery hybrid system  

Energy Technology Data Exchange (ETDEWEB)

Much attention is being paid to electric vehicles from environmental standpoints. One disadvantage of the electric vehicle is that its operative range is short. A means to overcome this difficulty is to use a hybrid battery which consist of a energy battery and a power battery. A method to make it possible to calculate the discharge characteristics of the battery hybrid system taking into account the charging behavior from the energy battery to the power battery is presented. In the proposed method, first the output voltage and the output current of an equivalent battery, which is required for realizing the given operating pattern are calculated. Next, the conduction ratio of the main chopper and the equivalent discharge of electric charge of each battery are calculated. These calculated data are used to calculate the operating range.

1980-05-01

457

The influence of stray radiation on image quality  

International Nuclear Information System (INIS)

The present state of knowledge on the influence of stray radiation on image quality and its physical description and quantification is summarized. Experimental results on the influence of physical parameters on the fraction of scattered radiation and the effect of scatter reduction by air gap technique and secondary radiation grids are committed. Open theoretical and practical problems and the limitations of common methods of scatter reduction are pointed out. (author).

461

Space Radiation Detector with Spherical Geometry  

Science.gov (United States)

A particle detector is provided, the particle detector including a spherical Cherenkov detector, and

2011-01-01

463

Solar Radiation Pressure Binning for the Geosynchronous Orbit  

Science.gov (United States)

Orbital maintenance parameters for individual satellites or groups of satellites have traditionally

2011-01-01

464

Self-filling and self-purging apparatus for detecting spontaneous radiation from substances in fluids  

Energy Technology Data Exchange (ETDEWEB)

Disclosed herein is a radiation detector providing for the in situ automatic sampling of fluids containing substances emitting radiation, especially Cerenkov radiation. The detector permits sampling within well casings and is self-purging such that no additional provisions must be established for the storage and disposal of contaminated fluids.

1993-01-01

466

Radiological equipment for emergencies  

Energy Technology Data Exchange (ETDEWEB)

A brief guide to training and equipment needed to effectively manage victims of radiation accidents. (DT)

1985-01-01

468

Radiation-annealing hardening of vanadium  

International Nuclear Information System (INIS)

A study is made of the mechanical properties of vanadium irradiated with fast neutrons up to dose 8.6.10"-"4 dpa, as a function of the temperature of post-radiation annealing. The radiation-annealing hardening (RAH) effect is observed at 300"oC, in agreement with previous studies. It is established for the first time that RAH is accompanied by fall in ductility. A phenomenological model is described which explains the dependence of RAH on radiation dose and temperature, as well as on the content of chemically active alloying impurities. (author).

470

Radiation Protection of the Organism (Selected Chapters)  

Science.gov (United States)

... biologically important compounds is sharply lowered with passage of the solutions to the cell an organ, where their sensitivity ...

1970-12-11

471
474

Multi-spectral schottky barrier infrared radiation detection array  

Energy Technology Data Exchange (ETDEWEB)

A multi-spectral Schottky barrier infrared detector array in which individual pixels of radiation from a remote radiating object are detected by two or more Schottky barrier infrared radiation detectors each having a different spectral response so as to provide a ''color'' discrimination for the array.

1983-12-27

475

Multi-spectral schottky barrier infrared radiation detection array  

International Nuclear Information System (INIS)

A multi-spectral Schottky barrier infrared detector array in which individual pixels of radiation from a remote radiating object are detected by two or more Schottky barrier infrared radiation detectors each having a different spectral response so as to provide a ''color'' discrimination for the array.

476

Kinetics of low-temperature radiation hardening of metallic materials under irradiation  

British Library Electronic Table of Contents (United Kingdom)

A formula is obtained which describes the kinetics of low-temperature radiation hardening caused by creation of dislocation loops of interstitial type during irradiation. The radiation hardening of aluminum and vanadium is estimated using this formula and results of experiments on studying processes of nucleation and growth of interstitial dislocation loops in these materials by transparent electron microscopy. It is shown that the proposed formula is valid for description of the kinetics of low-temperature radiation hardening.

2011-01-01

477

Infrared processes in the auroral zone  

International Nuclear Information System (INIS)

... aurorae carbon dioxide emission spectra infrared radiation nitrogen nitrogen

8432-01-01

479

Induced radiation during scattering of channeled electrons and positrons by point defects  

Energy Technology Data Exchange (ETDEWEB)

In scattering of channeled particles by point defects and in emission of gamma rays in the spontaneous-radiation spectral region conditions are attained where the momentum transferred to the defect is taken up by the crystal as a whole. This leads to coherent and interference effects in the radiation from the crystal defects. When the longitudinal momentum transferred is zero, an induced radiation effect appears in the transitions between the states of transverse motion.

1984-12-01

482

Four cases of bowel perforation following radiation therapy for cervical cancer  

Energy Technology Data Exchange (ETDEWEB)

External radiation dose exceeded 5,000 rad in three cases, and intravaginal radiation dose was 5,000 rad in one case. Radiation damage including perforation was seen in the end of ileus in one case, in the sigmoid and rectum in two cases, and in the end of ileus, sigmoid and rectum in the last case. Satisfactory results were obtained by the removal of the ileocecum in the case of the damage in the end of the ileus. However, only colostomy was performed for the damage in the sigmoid and rectum.

1984-10-01

483

Experts' discussion on the possibility of quantification of the radiation hazard  

International Nuclear Information System (INIS)

Due to the intensity and vast number of subjects, this Bremen experts' discussion, too, could discuss only part of the problem of the possibilitiy to quantify the radiation hazard. One preliminary result is that there is no scientific proof of the harmlessness of radiation exposure during normal operation of a nuclear power plant, either within the plant or in its vicinity. Other results are that some important questions can not be answered yet, and that there are important hints on the dangers even of low radiation doses. (GL).

1978-01-01

484

Effective dose equivalent in nuclear medicine investigations  

International Nuclear Information System (INIS)

... radiation hazards hazards health hazards MEDICINE. SOMATICALLY

1984-05-07

487

Cooperative spontaneous emission from two different atoms  

International Nuclear Information System (INIS)

The total radiation rate, angular distribution of the emitted energy and photon correlations of the cooperative spontaneous radiation from two atoms with different resonance frequencies and spontaneous decay rates are calculated. Contrary to the case of two identical atoms oscillations appear in the total radiation rate and the spatial distribution of the total number of emitted photons differs from the single-atom radiation pattern. The effect of the dipole-dipole near-field interaction on the time evolution of the atomic system is discussed. (author).

1986-01-01

488

Cluster-loop structure influence on molybdenum radiation hardening  

International Nuclear Information System (INIS)

Results on defect structure study and degree of molybdenum radiation hardening irradiated by fission neutrons and medium energy alpha-particles are presented. It is shown that molybdenum irradiation by alpha-particles and neutrons leads to different degree of material hardening for the same damage level. It is established that molybdenum radiation hardening is mainly defined by radiation defect clusters visible in electron microscope whose coefficient of rigidity depends on their size. 5 refs.; 6 figs.; 2 tabs. (author).

1990-05-22

492

About tachyons  

International Nuclear Information System (INIS)

... Part A: The electromagnetic radiation of a charged tachyon. Part B: Some