Wheeling electric power, the transmission of electricity not owned by an electric utility over its transmission lines, is a term not generally recognized outside the electric utility industry. Investigation of the term`s origin is intriguing. For centuries, wheel has been used to describe an entire machine, not just individual wheels within a machine. Thus we have waterwheel, spinning wheel, potter`s wheel and, for an automobile, wheels. Wheel as a verb connotes transmission or modification of forces and motion in machinery. With the advent of an understanding of electricity, use of the word wheel was extended to be transmission of electric power as well as mechanical power. Today, use of the term wheeling electric power is restricted to utility transmission of power that it doesn`t own. Cogeneration ...
Excessive physical activity plays an important role in the progression of anorexia nervosa (AN) by accelerating weight loss during dietary restriction. To search for mechanisms underlying this trait, a panel of mouse chromosome substitution strains derived from C57BL/6J and A/J strains was exposed to a scheduled feeding paradigm and to voluntary running wheel (RW) access. Here, we showed that A/J chromosomes 4, 12 and 13 contribute to the development of a disrupted RW activity in response to daily restricted feeding. This pattern is characterized by intense RW activity during the habitual rest phase and leads to accelerated body weight loss. Regions on mouse chromosomes 4, 12 and 13 display homology with regions on human chromosomes linked with anxiety and obsessionality in AN cohorts. The...
Several of the issues of the workshop are addressed from the perspective of a potential Space Station developer and energy wheel user. Systems considerations are emphasized rather than component technology. The potential of energy storage wheel (ESW) concept is discussed. The current status of the technology base is described. Justification for advanced technology development is also discussed. The study concludes that energy storage in wheels is an attractive concept for immediate technology development and future Space Station application.
Essential in mitosis, the human Kinesin-5 protein is a target for >80 classes of allosteric compounds that bind to a surface-exposed site formed by the L5 loop. Not established is why there...Full Text Available
The patent application describes an anti-friction worm-wheel assembly wherein the anti-friction elements are rollers carried by the worm element. The rollers sequentially move through grooves in the edge surface of the wheel element to transmit drive forc...
The purpose of this study was to determine whether the use of wheeled mobility devices differed with respect to age, gender, residential setting, and health-related factors among older adults. A total...Full Text Available
Analyzed are methods for optimizing productivity of coal surface mining systems which consist of bucket wheel excavators, belt conveyors, and dumping conveyors. System productivity depends on adjustment of belt conveyor capacity to productivity of bucket wheel excavators. Factors which influence productivity of bucket wheel excavators are analyzed: dimensions and geometry of bucket wheels, rated power of drive systems for bucket wheels and properties of mined materials (coal or overburden). Indices used in Czechoslovakia for assessing productivity of bucket wheel excavators are compared. Factors which influence capacity of belt conveyors are also analysed: belt dimensions, belt geometry, angle of repose of hauled coal or overburden, and haulage speed of a belt conveyor. Investigations carried out in brown coal surface mines in Czechoslovakia show that conveyor ...
The conceptual design of the support structures of the EM muon chambers is presented. On each side of the detector the EM chambers are arranged in four layers: one layer of MDTs and the three layers of TGCs. The chambers are mounted on four individual wheel structures per side. The four wheels are inclined by 1.23% and suspended from two longitudinal beams parallel to the beam axis. In order to allow for the opening of the ATLAS detector the wheels can be displaced longitudinally over a distance of 6 m. In addition individual wheels can be separated from each other by up to 1 m for maintenance purposes.
The wind unit working wheel has 4 radial rectangular frames arranged in two vertical planes which are perpendicular to each other. In the planes limited by the frames, on loop hinges with limiting supports, there are flat blades. When the working wheel rotates under the influence of wind pressure, the blades automatically occupy a vertical or horizontal (wind vane) position depending on the direction of blade motion and the direction of wind velocity.
The paper presents experimental investigations of main features of plasma surface interaction and energy transfer to the material surface in dependence on plasma heat loads. The experiments were performed with QSPA repetitive plasma pulses of the duration of 0.25 ms and the energy density up to 2.5 MJ/m2. Surface morphology of the targetsexposed to QSPA plasma screams is analyzed. Relative contribution of the Lorentz force and plasma pressure gradient to the resulting surface profile is discussed. development of cracking on the tungsten surface and swelling of the surface are found to be in strong dependence on initial temperature of the target.
... Wheeled Vehicle) equipped with a MILSTAR terminal was driven ... textbooks including Ronald W. Wolff, Stochastic Modeling and The ... Queue Length ...
Measurement of serum biochemical parameters in response to metal exposures can be especially useful to help identify target organs of toxicity as well as the general health status of animals. Oreochromis niloticus were exposed to 5.0?mg/L?Zn, 1.0?mg/L?Cd, and 5.0?mg/L?Zn?+?1.0?mg/L?Cd mixture for 7 and 28?days, and alterations in serum enzyme activities and ion levels were measured. Significant changes in all the biochemical parameters were found to be time dependent. Following metal exposure, alkaline phosphatase activity was elevated at both exposure periods. No changes in activities of lactate dehydrogenase and lipase were observed in response to single or combined Zn and Cd exposure at 7?days while they increased at 28?days. Fish exposed to metals showed a decrease in cholinesterase ac...
The invention concerns an improvement of a cooling device for rotors of multistage axial steam turbines by providing in the first stage of each group of turbine stages a circulation loop connecting the wheel chamber on the inlet side of the rotor disc of the first stage with the wheel chamber on its outlet side. This is to cause the cooling effect not to be hampered by gap widths of the seal in the bottom range of the rotor blades changing during operation. Design particulars are described in detail. (UWI).
Here we show that self-propulsion in quantum vacuum may be achieved by rotating or aggregating magneto-electric nano-particles. The back-action follows from changes in momentum of electro-magnetic zero-point fluctuations, generated in magneto-electric materials. This effect may provide new tools for investigation of the quantum nature of our world. It might also serve in the future as a "quantum wheel" to correct satellite orientation in space.
Better properties of magnesium make it a natural choice for use as an anode material in rechargeable batteries. However, the magnesium alloy thin sheets used in rechargeable batteries were produced by ingot casting and rolling. That technology was so complex and the cost was high. Rapidly solidification by melt spinning is an effect way to solve that problem. In this paper, the technology of rapidly solidified (RS) ribbons in Mg-3%Al-1%Zn-0.2%Mn alloy has been investigated using melt spinning technique. The effect of wheel speed on thickness and microhardness of the ribbons is presented. Microhardness is found to increase with the wheel speed. Rapidly solidification leads to small grains (1{proportional_to}2 {mu}m). The plasticity of the ribbons was well. The quantity of Mg{sub 17}Al{sub 12} decreases with the increase in wheel speed. When the wheel speed reaches 1600 rpm, no Mg{sub 17}Al{sub 12} phase ...
Numerous transmethylation reactions are required for normal plant growth and development. S-adenosylhomocysteine hydrolase (SAHH) and adenosine kinase (ADK) act coordinately to recycle the by-product of these reactions, S-adenosylhomocysteine (SAH) that would otherwise competitively inhibit methyltransferase (MT) activities. Here, we report on investigations to understand how the SAH produced in the nucleus is metabolized by SAHH and ADK. Localization analyses using green fluorescent fusion proteins demonstrated that both enzymes are capable of localizing to the cytoplasm and the nucleus, although no obvious nuclear localization signal was found in their sequences. Deletion analysis revealed that a 41-amino-acid segment of SAHH (Gly(150)-Lys(190)) is required for nuclear targeting of this enzyme. This segment is surface exposed, shows unique sequence conservation patterns in plant SAHHs, and possesses additional features of protein-protein ...
The National Spallation Neutron Source (NSNS), in which neutrons are generated by bombarding a liquid mercury target with 1 GeV protons, will place extraordinary demands on materials performance. The target structural material will operate in an aggressive environment, subject to intense fluxes of high energy protons, neutrons, and other particles, while exposed to liquid mercury and to water. Components that require special consideration include the Hg liquid target container and protective shroud, beam windows, support structures, moderator containers, and beam tubes. In response to these demands a materials R and D program has been developed for the NSNS that includes: selection of materials; calculations of radiation damage; irradiations, post irradiation testing, and characterization; compatibility testing and characterization; design and implementation of a plan for monitoring of materials ...
The photocytotoxic effect of hypericin (Hyp) targeted by two different delivery techniques, namely, liposomes and anti-hepatocyte specific antigen (anti-HSA) was investigated. Optical absorption and steady-state fluorescence were used to analyze the conjugation of Hyp with anti-HSA model and to evaluate the encapsulation capacity and drug release in a liposome model. Particle size and thermal analysis of the prepared liposomes were performed using laser-light scattering and differential scanning calorimetry (DSC), respectively. Viability study of HepG2 cells exposed to Hyp in the two delivery systems, in the dark and following visible light irradiation, was performed in comparison to free Hyp. The intracellular uptake and localization of Hyp in HepG2 cells were analyzed by means of spectro...
Atrazine is one of the most commonly used herbicides in the United States. While effective on target plants, it has been associated with harmful health effects in non-target organisms such as fish, amphibians and mammals. In this study, growth effects on human liver cells were determined after exposure to increasing concentrations of this herbicide. Growth of immortalized human hepatoma HepG2 cells was inhibited by atrazine concentrations of 625 ppb after 72 h exposure and flow cytometry analysis demonstrated HepG2 cells exposed to 100 ppb atrazine accumulated in S phase after 48 h compared to untreated cells. Expression of cell cycle specific cyclin proteins was altered after atrazine exposure with cyclin E levels significantly decreased after a 24 h exposure and cyclin B levels decreased...
No magnetic monopoles were found in 2.5*10/sup 18/ primary proton- aluminium interactions produced by exposing an aluminium target to the Fermilab 300 GeV/c proton beam. Negative searches have also resulted from exposures of material to electrons at SLAC and from pp interactions at the CERN-ISR. The monopole pair production probability in proton-nucleon collisions is shown to be of order 10/sup -18/ or less, with 95% confidence level, if monopoles have masses less than 12 GeV. (24 refs).
To improve mirrors coating, we have modeled sputtering of binary oxide targets using TRIM code. First, we have proposed a method to calculate TRIM input parameters using on the one hand thermodynamic cycle and on the other hand Malherbe`s results. Secondly, an iterative processing has provided for oxide steady targets caused by ionic bombardment. Thirdly, we have exposed a model to get experimental sputtering yields. Fourthly, for (Ar - SiO{sub 2}) pair, we have determined that steady target is a silica one. A good agreement between simulated and experimental yields versus ion incident angle has been found. For (Ar - Ta{sub 2} O{sub 5}) pair, we have to introduce preferential sputtering concept to explain discrepancy between simulation and experiment. In this case, steady target is tantalum monoxide. For (Ar - Ta+O{sub 2}) pair, tantalum sputtered by argon ions in reactive oxygen ...
Two refrains heard in the current retail wheeling debate are that a restructuring of the electric utility industry is inevitable and that its consequences are unpredictable. Notwithstanding the benefits of open competition, there are specific disadvantages of unlimited retail wheeling for some existing independent facilities and especially for hydropower plants. A capital-intensive industry, hydropower is not well-postured to compete effectively in the short-term, against new technologies and fuel sources available in the current marketplace. Hydropower is flat out non-competitive on a price basis with available new capacity. Unless hydro is afforded the same government supports offered to other renewable energy sources, only municipal plants with access to subsidized financing rates and pumped storage plants are going to be built.
Magnetic drug targeting, using core-shell magnetic carrier particles loaded with anti-cancer drugs, is an emerging and significant method of cancer treatment. Gold shell-iron core nanoparticles (Fe@Au) were synthesized by the reverse micelle method with aqueous reactants, surfactant, co-surfactant and oil phase. XRD, XPS, TEM and magnetic property measurements were utilized to characterize these core-shell nanoparticles. Magnetic measurements showed that the particles were superparamagnetic at room temperature and that the saturation magnetization decreased with increasing gold concentration. The anti-cancer drug doxorubicin (DOX) was loaded onto these Fe@Au nanoparticle carriers and the drug release profiles showed that upto 25% of adsorbed drug was released in 80 h. It was found that the amine (-NH2) group of DOX binds to the gold shell. An in vitro apparatus simulating the human circulatory system was used to determine the retention of these nanoparticle ...
operating at the maximal setting of speed control dials used to control their ...evaluates their energy performance when the speed control dial used ...FFUs when the speed control dial used for adjusting fan wheel speeds in each FFU was
Describes performance of excavator teeth manufactured with a new hard alloy. The alloy was developed by the Donetskii Politeknicheskii Institute. Its composition consists of a high-chromium steel with a larger amount of titanium than serial alloy, and a nitrogen additive. Trial tests of new alloy teeth were carried out in the Severnyi and Vershinskii coal surface mines. The teeth were attached to EhRP, EhPG and EhR bucket wheel excavators. Abrasive wear of 129 experimental teeth and 134 serial teeth was compared for different excavation conditions. Test results are tabulated; advantages of the new experimental teeth are listed. 3 refs.
The RD50 collaboration has been exploring the development of radiation hard semiconductor devices for very high-luminosity colliders since 2002. The target fluence to qualify detectors set by the anticipated dose for the innermost tracking layers of the future upgrade of the CERN large hadron collider (LHC) is 1016 1 MeV neutron equivalent (neq) cm-2. This is about an order of magnitude higher than the maximum dose for the most exposed silicon detectors in the current machine. RD50 investigates the radiation hardening of silicon sensors from many angles: improvement of the intrinsic tolerance of the substrate material, optimisation of the readout geometry and study of novel design of detectors. A review of some of the recent activities within RD50 is here presented.
The RD50 collaboration has been exploring the development of radiation hard semiconductor devices for very high-luminosity colliders since 2002. The target fluence to qualify detectors set by the anticipated dose for the innermost tracking layers of the future upgrade of the CERN large hadron collider (LHC) is 1016 1MeV neutron equivalent (neq) cm-2. This is about an order of magnitude higher than the maximum dose for the most exposed silicon detectors in the current machine. RD50 investigates the radiation hardening of silicon sensors from many angles: improvement of the intrinsic tolerance of the substrate material, optimisation of the readout geometry and study of novel design of detectors. A review of some of the recent activities within RD50 is here presented.
Experimental measurements were made of the production cross sections and energy distributions of gamma rays emitted when the stable targets /sup 88/Sr, /sup 89/Y and /sup 90/Zr are exposed to protons in the energy range 3 to 8 MeV. The data are being analyzed using a recent version of the Uhl statistical model code. One conclusion is that while the gamma-ray strength functions employed reproduce the proton capture cross sections, they do not achieve the same degree of hardness observed in the measured spectra. To do so, their lower energy regions must be modified; such changes, however, do not affect the capture cross sections. 7 references.
Despite the fact that humans are exposed to multiple forms of mercury (elemental, inorganic, and organic), most research on mercury toxicity has focused on methylmercury (MeHg) and on neurotoxic outcomes and mechanisms. Recent work has indicated that the immunotoxic effects of mercury compounds may be significant contributors to human disease as well as mechanistically relevant to other target organ toxicities. In this study, we compared the effects of inorganic Hg (iHg) to organic Hg species (MeHg and ethylmercury, EtHg) in human peripheral blood mononuclear cells (PBMCs) in vitro at sub-cytotoxic concentrations, using methods developed to characterize response of human PBMCs to iHg in vitro. PBMCs were isolated from six volunteer blood donors (three males and three females) and cultured ...
CR-39 detectors have been exposed to a 5.9-MeV antiproton beam using the low energy antiproton ring (LEAR) facility at CERN. At this energy, tracks of antiprotons appear in a CR-39 detector after 135 min of etching in 6 M NaOH at 70C. Fluence of the antiproton beam has been determined using track density. We have also found tracks in the etched CR-39 detector at different depths (250-500 mum). These tracks have resulted from the annihilation of antiprotons with the constituents (H, C and O) of the CR-39 detector. The goal of the experiment is to develop a simple and low-cost method to study properties of antiparticles and those formed after annihilation of these particles with the target matter.
Containing an epidemic at its origin is the most desirable mitigation. Epidemics have often originated in rural areas, with rural communities among the first affected. Disease dynamics in rural regions have received limited attention, and results of general studies cannot be directly applied since population densities and human mobility factors are very different in rural regions from those in cities. We create a network model of a rural community in Kansas, USA, by collecting data on the contact patterns and computing rates of contact among a sampled population. We model the impact of different mitigation strategies detecting closely connected groups of people and frequently visited locations. Within those groups and locations, we compare the effectiveness of random and targeted vaccinations using a Susceptible-Exposed-Infected-Recovered compartmental model on the contact network. Our simulations show that the targeted ...
We describe the isolation and genetic characterization of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced mutations in the phage P22 mnt repressor gene cloned in plasmid pBR322. Mutations in the mnt repressor gene or its operator on this plasmid, pPY98, confer a tetracycline resistance phenotype, whereas the wild-type plasmid confers tetracycline sensitivity. Cells carrying pPY98 were briefly exposed to MNNG to give 20 to 40% survival and a 50- to 100-fold increase in tetracycline-resistant cells. DNA sequence analysis showed that 29 to 30 MNNG-induced mutations were GC-to-AT transitions and one was an AT-to-GC transition. About 80% of the mutations are in three hotspots. This mutation spectrum is consistent with the proposed mechanism of mutagenic action of MNNG, which involves mispairing of an alkylated base, O/sup 6/-methylguanine. The mnt gene may be a useful target for determining mutagenic specificity at the nucleotide level ...
This paper evaluates activities from 1981 to 1985 of the Donetskgormash association which develops and manufactures equipment for coal mining. The association has manufactured 1,410 hoists, 274 blowers and 26 bucket wheel excavators. Sixteen experimental units of new mining equipment have been developed, among others the RPM 3600-42.5/90 bucket wheel excavator (with a capacity of 3,600 m/sup 3//h for coal handling in storage yards of large power plants), the bucket wheel system used in the EhR 630-10.5/0.5 excavator and the PZ 1600-17/20 materials handling system. Among 20 equipment types manufactured from 1981 to 1985, 4 types were manufactured in the USSR for the first time (e.g. the MPP shaft sinking system and the VOD-50 mine blower). Use of new types of equipment manufactured by the association economized about 46 million rubles in coal mines. From 1986 to 1990 production of mining equipment in the association should ...
As the Electric Power Industry is actively preparing for a restructured future where retail wheeling is practiced ideally and efficiently in a competitive market-based environment, concerns may arise legitimately on how system reliability and integrity can be ensured in an environment where markets have an enhanced role. As these concerns may be justified, at least for a transition period, this paper presents a proposal which outlines how the generally accepted requisite capacity, energy, and ancillary services standards may be satisfied through market reliance and minimal coordination by a Reliability Monitoring and Ancillary Services Managing Entity or Independent System Operator. A Strawman detailing one -- and by no means the only -- future scenario inspired by the recent NEPOOL restructuring discussions in New England is presented to demonstrate that market-based competition and flexibility are compatible with a reliable Power System.
Full text: DNA rearrangement events leading to chromosomal aberrations are central to ionizing radiation-induced cell death. Although DNA double-strand breaks are probably the lesion that initiates formation of chromosomal aberrations, little is understood about the molecular mechanisms that generate and modulate DNA rearrangement. Examination of the sequences that flank sites of DNA rearrangement may provide information regarding the processes and enzymes involved in rearrangement events. Accordingly, we developed a method using inverse PCR that allows the detection and sequencing of putative radiation-induced DNA rearrangements in defined regions of the human genome. The method can detect single copies of a rearrangement event that has occurred in a particular region of the genome and, therefore, DNA rearrangement detection does not require survival and continued multiplication of the affected cell. Ionizing radiation-induced DNA rearrangements were detected in several different ...
The investigation of important wear processes in the railway technique, especially the differentiation of the parameters influencing the wear process, requires extensive test programmes and thus high resolving methods to determine the wear. Radiometric methods enable considerably greater measuring accuracy with the help of the activation of materials than an observation of measurement or measuring changes. (orig./LH).
The technology status of the dynamics and controls discipline as it applies to energy storage wheel systems was evaluated. No problems were identified for which an adequate solution could not be proposed. Design issues that influence control were addressed. The dynamics and control aspects associated with the energy storage system concept and its various constituent parts, and the control tasks attendant to large, manned spacecraft are discussed.
An analysis of the diagnosis of loading and service dependability of a rail-mounted excavator used in surface lignite mining is described. Wheel power vibrations in electric motor bearings and electric motor input bearings to the gearbox were measured in situ, in horizontal, vertical, and axial directions. The data were analyzed using a mathematical relationship. The results are presented in a loading diagram that shows the deterioration and the acceptable lower bound of machine conditions over time. Work is continuing. 5 refs., 1 fig.
We investigate some aspects of the radiation damage mechanisms in biomolecules, focusing on the modelling of resonant fragmentation caused by the attachment of low-energy electrons (LEEs) initially ejected by biological tissues when exposed to ionizing radiation. Scattering equations are formulated within a symmetry-adapted, single-center expansion of both continuum and bound electrons, and the interaction forces are obtained from a combination of ab initio calculations and a nonempirical model of exchange and correlation effects developed in our group. We present total elastic scattering cross-sections and resonance features obtained for the equilibrium geometries of glycine, alanine, proline and valine. Our results at those geometries of the target molecules are briefly shown to qualitatively explain some of the fragmentation patterns obtained in experiments. We further carry out a one-dimensional (1D) modeling for the dynamics of ...
Target vessel materials used in spallation neutron source will be exposed to proton and neutron irradiation and mercury immersion environments. In order to evaluate the surface degradation of the vessel candidate materials due to such environment, the triple-ion beam irradiation taking the spallation reaction into account and mercury immersion tests were carried out. Mechanical properties of the gradient surface layer were evaluated by the inverse analysis with multi-layer model that considers distribution of surface characteristic was applied to the load and depth curves measured by using the instrumented indentation machine. Transmission electron microscopic observations were performed to evaluate the changes of microstructure in irradiated surface layer using focused ion-beam cut micro-specimen. The mechanical properties distributions in the surface layer were evaluated quantitatively and the changes in microstructures were correspondent to ...
In this work we present an ultra-low temperature method for the oxidation of an amorphous silicon-carbide-nitride (SiCN) material. The SiCN is deposited on silicon substrates by plasma enhanced chemical vapor deposition using CH{sub 4}, SiH{sub 4}, and N{sub 2} chemistry. The physical and chemical properties are characterized for the as-deposited SiCN and post-oxidized films are discussed. The SiCN film is exposed to oxygen plasma, where it undergoes a chemical transformation into a binary SiO{sub 2} material system. A 1.7 nm/min oxidation rate is typical for this process and compares favorably to oxidation methods utilizing much higher temperatures. The substrate temperature remains extremely low throughout the oxidation process, T{sub s} < 200 deg. C. Changes in film stress, optical constants, film thickness, surface roughness, and film density are measured. Chemical analysis by X-ray photoelectron spectroscopy is reported for both the as-deposited and ...
Combinations of exposure concentrations, durations and frequencies were tested in four-week inhalation exposures followed by two weeks of recovery to define the interactive effects of these variables on biologic responses and to select the most-sensitive biologic response parameters for the subsequent subchronic studies. Response surface modeling was used for the experimental design and statistical analysis of the data. Results of preliminary testing suggested that exposure duration and frequency did not have major effects. Subsequently, male and female Sprague-Dawley rats were exposed in separate studies to RP/BR aerosols ranging from 0.40 to 1.20 mg/1 or to filtered air for 2.25 hr/day on four days/week for four weeks. Test-atmosphere monitoring data demonstrated that aerosol concentrations were consistently within 4% of the target values and mean particle size ranged from 0.44-0.64 ..mu..m with mean sigma g's of 1.66-1.97. During ...
Perinatal exposure to cadmium (Cd) or methylmercury (MeHg) results in impaired neurodevelopment. Thyroid hormone is essential for normal brain development. However, the issue whether Cd or MeHg, especially at low doses, interrupts thyroid hormone action remains to be investigated. In the present study, effects of perinatal exposure to low levels of Cd or MeHg on thyroid hormone metabolism were examined using metallothionein I and II (MT-I/II) null or wild-type neonatal mice. Dams were exposed to 10 mg/L water of Cd or 5 mg/kg chow of MeHg from gestational day 0 to post-natal day 10 (PND 10). Sera, livers and brains were collected from neonates on PND 10. Iodothyronine deiodinase activities and serum thyroxine (T4) concentrations were measured. MeHg exposure failed to induce changes in serum T4 levels and liver type 1 deiodinase (D1) and brain type 2 deiodinase (D2) activities regardless of the MT genotype. However, exposure to MeHg resulted in a decrease in brain ...
To evaluate the role of phytochelatins and metallothioneins in heavy metal tolerance of black mangrove Avicennia germinans, 3-month-old seedlings were exposed to cadmium or copper for 30 h, under hydroponic conditions. Degenerate Mt2 and PCS primers were synthesized based on amino acid and nucleotide alignment sequences reported for Mt2 and PCS in other plant species found in GenBank. Total RNA was isolated from A. germinans leaves and two partial fragments of metallothionein and phytochelatin synthase genes were isolated. Gene expression was evaluated with reverse transcripatase-polymerase chain reaction (RT-PCR) amplification technique. Temporal analysis showed that low Cd{sup 2+} and Cu{sup 2+} concentrations caused a slight (but not significant) increase in AvMt2 expression after a 16 h exposure time, while AvPCS expression showed a significant increase under the same conditions but only after 4 h. Results strongly suggest that the rapid increase in AvPCS ...
To evaluate the role of phytochelatins and metallothioneins in heavy metal tolerance of black mangrove Avicennia germinans, 3-month-old seedlings were exposed to cadmium or copper for 30 h, under hydroponic conditions. Degenerate Mt2 and PCS primers were synthesized based on amino acid and nucleotide alignment sequences reported for Mt2 and PCS in other plant species found in GenBank. Total RNA was isolated from A. germinans leaves and two partial fragments of metallothionein and phytochelatin synthase genes were isolated. Gene expression was evaluated with reverse transcripatase-polymerase chain reaction (RT-PCR) amplification technique. Temporal analysis showed that low Cd"2"+ and Cu"2"+ concentrations caused a slight (but not significant) increase in AvMt2 expression after a 16 h exposure time, while AvPCS expression showed a significant increase under the same conditions but only after 4 h. Results strongly suggest that the rapid increase in AvPCS expression ...
The paper present the results of the study on D.U. (depleted uranium) contamination in the environment and possible effects on animal healths in the region o f Bujanovac. Samples of soil, feed, leaves, grass, lichen, moss, honey and water were collected randomly in 2003/2004 in the vicinity of the target area (500-1000 m) and 5 km from the target area. Activity of the radionuclides ({sup 226}Ra, {sup 232}Th, {sup 40}K, {sup 210}Pb, {sup 238}U, {sup 235}U, {sup 137}Cs, {sup 7}Be) in soils, grass, lichen, moss and honey was determined on Hp Ge detector (Canberra, relative efficiency 23%) by standard gamma spectrometry. Total alpha and beta activity in water was determined on proportional alpha/beta counter (Canberra 2400, efficiency for alpha emitters 11%, efficiency for beta emitters 30%). Non significantly higher values of concentrations of {sup 226}Ra, {sup 232}Th, {sup 238}U and {sup 235}U were measured in the immediate vicinity of the ...
There are many factors contributing to the changes taking place within the electric utility industry. The environmental pressures on the industry are substantial and include the global warming issue, hazardous and nuclear waste challenges, air toxicities, and the electromagnetic field controversy. An issue of special concern is deregulation of the industry, which brought with it retail wheeling, wholesale wheeling, transmission access, and market-based pricing, all of which have greatly shaken the industry. The changes are expected to happen quickly. This is quite different from the 31 years it took to deregulate the telecommunications industry, the 15 to 20 years for railroads, the 9 years for the natural gas industry, and the 2 years for the airline industry. Historically there has been a general willingness among the utilites to share information through collaborative research. Research and development is viewed as a cost and not an ...
Repair and maintenance for equipment used in the Belchatow brown coal mine and organizational models of repair services in the mine are discussed. Maintenance of earthmoving equipment, spreaders, bucket wheel excavators, loaders and other coal handling equipment, belt conveyors and drive systems for belt conveyors is discussed. Repair shops in the mine also manufacture about 35% of spare parts and elements for equipment used in the mine. Reliability of mining equipment, repairs and repair capacity of the shops are discussed. Organizational models of repair services, equipment used by these services and repair personnel are described. Effects of repair services on operation of the mine are evaluated.
This very significant and useful report assessed state-of-the-art geothermal technologies. The findings presented in this report are the result of site visits and interviews with plant owners and operators, representatives of major financial institutions, utilities involved with geothermal power purchases and/or wheeling. Information so obtained was supported by literature research and data supplied by engineering firms who have been involved with designing and/or construction of a majority of the plants visited. The interviews were conducted by representatives of the Bonneville Power Administration, the Washington State Energy Office, and the Oregon Department of Energy during the period 1986-1989. [DJE-2005
Autonomous robots or remotely operated vehicles have raised high hopes in the military and industrial communities because of the potential safety improvement and gain of productivity they may provide. Waste management on nuclear sites, pallet manipulation in factories, interventions on battle-fields, etc., are actively studied. A lot of these applications require powerful four-wheel vehicles, the kinematics of which is similar to that of a car. Such vehicles have three degrees of freedom: the (x,y) positions in a plane and the orientation of the vehicle. Path planning is often understood as only changing the position of the vehicle, whereas the tasks performed by this kind of robot requires a perfect orientation of the vehicle: forklifting a pallet or docking at a loading or unloading station requires accuracy in the orientation of the vehicle. It is this requirement and the kinematic constraints of the motion mode which have led to the path-planning algorithm ...
All microRNA (miRNA) target—finder algorithms return lists of candidate target genes. How valid is that output in a biological setting? Transcriptome analysis has proven to be a useful approach...Full Text Available
A retrospective review was made of 2,659 autopsy patients obtained during the past 31 years and a half in Hiroshima Atomic Bomb Hospital. Of the patients, 1,328 (49.9%) were A-bomb survivors. Five hundred and six A-bomb survivors (38.1%) had been exposed at up to 2,000 m from the hypocenter. There was no correlation between the incidence of malignancy and the presence of exposure to A-bombing. The incidence of multiple malignancy was slightly higher in A-bomb survivors exposed at the place nearer the hypocenter. In the group of A-bomb survivors, cancer of the lung was the most common for men; and cancer of the stomach was the most common for women. The incidence of malignancy has been high in the exposed group during the early eras of examination; however, this figure has recently become high in the non-exposed group. Regarding the kinds of malignancy, there was no significant difference between the ...
Endocrine disrupting chemicals can induce malformations and impairment of reproductive function in experimental animals and may have similar effects in humans. Recently, the environmental obesogen hypothesis was proposed, suggesting that environmental chemicals contribute to the development of obesity and insulin resistance. These effects could be related to chemical interaction with nuclear receptors such as the peroxisome proliferator activated receptors (PPARs). As several testosterone-reducing drugs are PPAR activators, we aimed to examine whether four PPAR agonists were able to affect fetal testosterone production and masculinization of rats. Additionally, we wished to examine whether these chemicals affected fetal plasma levels of insulin and leptin, which play important roles in the developmental programming of the metabolic system. Pregnant Wistar rats were exposed from gestation day (GD) 7-21 to diisobutyl phthalate (DiBP), butylparaben, ...
We describe the synthesis and characterization of superparamagnetic iron oxide nanoparticle based heavy metal sorbents with various surface chemistries that demonstrate an excellent affinity for the separation of heavy metals in contaminated water systems (i.e. spiked Columbia river water). The magnetic nanoparticle sorbents are prepared from an easy to synthesize iron oxide precursor, followed by a simple, one-step ligand exchange technique to introduce the organic surface functionality of interest chosen to target either specific or broader classes of heavy metals. Functionalized superparamagnetic nanoparticles are excellent sorbent materials for the extraction of heavy metal contaminants from environmental and clinical samples since they are easily removed from the media once bound to the contaminant by simply applying a magnetic field. These engineered magnetic nanoparticle sorbents have an inherently high active surface area (often > 100 m2/g), allowing for ...
The control of piece size in ruptured rocks in coal sections is important as part of the general problem of increasing efficiency in the technology of open-pit mining operations. An attempt is made in this paper to estimate the rupture capacity of exposed rocks in coal sections based on a set of physicomechanical property indicators, using the methods of multidimensional statistical analysis. It was established that all the parameters for the physiocomechanical properties of the exposed rocks are highly correlated. The method proposed for determining criteria for explosive capacity is of interest in developing criteria for the destruction capacity (drillability, excavation capacity, etc.) in the exposed rocks of coal sections which are characterized by high variation in physical and mechanical properties.
exposed to persistent saltwater intrusion, a major factor in the decline of marsh ecosystems. The resulting increase in salinity from persistent flooding due to ...
A method of abrasion testing according to ASTM C 704-76 a is presented for steel fibre concrete mortar, fusion-cast basalt and a surface coating material and results of practical interest are mentioned. Due to the high technical demands on these materials and their specific fields of application, the very first test already supplied interesting findings. From the user's point of view, the method is an interesting alternative to the common test methods, e.g. according to DIN 52 108 (wheel test according to Boehme). In English-speaking countries, testing according to ASTM is often mandatory in the refractory industry in order to assure constant quality of refractory materials after setting. The method is characterized by good comparability and high accuracy of measurement. Only the test piece is exchanged while the test conditions remain constant, so that accurate information on the material studied is obtained.
HLW disposal is one of the largest issue to utilize Nuclear power safely. In the past study, the concept, which buffer materials and Overpacked waste were transported into underground respectively, have shown. The concept of pre-assembled engineered barrier has advantage to simplify the logistics and emplacement procedure, however there are difficulties to support heavy weight of pre-assembled package by equipment under the condition of little clearance between tunnel and package. In this study, Combination of air bearing and two degree-of-freedom wheels were suggested for transportation, and air jack was suggested for unloading and emplacement system. Also, whole system for transportation and emplacement procedure was designed, and Scale model test was examined to evaluate the feasibility of these concept and functions. (author)
This paper presents the test results of a research program to investigate the performance of polymeric insulators for 15-kV dead-end applications on distribution systems. The test program involved both new insulators from five different manufacturers and naturally-aged insulators removed from service on the distribution system of Pennsylvania Power and Light. The test series to evaluate the new insulators included: preconditioning treatments, salt fog and tracking wheel accelerated aging tests, electrical tests, and material and physical tests. The tests for the naturally-aged insulators were mainly limited to the electrical tests and the material and physical tests.
Measurements of smoke and NO emissions from a direct-injection diesel engine have shown that they are indeed influenced by inlet port design, even though the swirl numbers for the ports may be identical. The swirl numbers of the three ports used (tangential port, helical port and helical port with masked valve) were measured on a steady-state test rig using a paddle-wheel anemometer and impulse swirl meter. Flow measurements were carried out under motoring conditions with a constant-temperature, hot-wire anemometer. Is was possible to find a correlation between flow data and exhaust data as far as the in-cylinder air motion over a certain time interval is concerned.
The ultrasonic inspection pig system was described as being under development. This system was said to adopt the unique wheel type ultrasonic sensor which does not need couplant. This pig was designed to detect external corrosion in long-distance pipelines without interruption of the gas service. The wall-thickness measurement performance test and the travel performance test of the inspection pig in the test line confirmed that these performances satisfied the development specifications. However, the effect induced by the inner surface properties of the pipe and the influence of the pipe`s performance over long distances and for a long period of time still needed to be verified in an actual gas pipeline, and while the pipeline was actually in service. Improvements to the prototype model of the inspection pig were expected to include combinations of inspection pigs, with increases in battery and memory capacities to permit them to cope with in increased number of ...
GPM moves from the clean room to the test chamber on a dolly without wheels. Compressed air is pumped out under airpads that float the Spacecraft on a bed of air. nThe wind generated when the centrifuge moves at its maximum speed are more than 200 mph - that's tornado speed. But since they move with the centrifuge the satellites tested only feel 20 mph winds. nLeaning outward at 45 degrees for one test orientation, GPM comes within 28 inches of the wall. When lifted onto the platform it cleared the ceiling by only five inches. nNatural audio only. nVideo Credit: Brooke Harris n
A small fleet of classic London Taxis (Black cabs) equipped with hydrogen fuel cell power systems is being prepared for demonstration during the 2012 London Olympics. This paper presents a Life Cycle Analysis for these vehicles in terms of energy consumption and CO2 emissions, focusing on the impacts of alternative vehicle technologies for the Taxi, combining the fuel life cycle (Tank-to-Wheel and Well-to-Tank) and vehicle materials Cradle-to-Grave. An internal combustion engine diesel taxi was used as the reference vehicle for the currently available technology. This is compared to battery and fuel cell vehicle configurations. Accordingly, the following energy pathways are compared: diesel, electricity and hydrogen (derived from natural gas steam reforming). Full Life Cycle Analysis, usin...
The determination of residual stress (RS) in case-hardened steel gear truck synchronisers coated with thermal sprayed molybdenum was carried out using neutron and synchrotron X-ray diffraction. Two samples with different coating thicknesses (about 120 ?m and 1.4 mm) and different steel substrates (16MnCr5 and SAE4140, respectively) were investigated. Microanalysis revealed substantial porosity in both samples and some debonding was observed between the thin coating and the substrate. The bulk hardness of the SAE 4140 proved to be much higher than the 16MnCr5 and the surface case-hardening increased it by a further 20%. The full three-dimensional stress depth-profile was determined by neutron diffraction (ND) in both the coatings and the substrates, while synchrotron radiation allowed a dep...
There are many different types of open pit mining operations around the world, and the challenge for any drive system manufacturer is to produce a system(s) that will work satisfactorily in these mines. Several factors must be considered such as vehicle speed requirements, available engine horsepower, mine rolling resistance, grades, grade lengths, payload, and tire sizes. How well a particular drive system performs depends on the size, weight, and available tractive/retarding effort. In addition to performance, the system must also have an operating cost that will be acceptable over the life of the equipment. Today the choice of drive systems is not only between mechanical and electrical drives, but also within these categories are the different manufacturers. Regardless of how the power is provided to the rear wheels, the job must be accomplished reliably and at an acceptable cost. This paper covers the characteristics of an electric drive system and how it is ...
Human antibodies targeting prostate cancer cell surface epitopes may be useful for imaging and therapy. The objective of this study was to evaluate the tumor targeting of an internalizing human...Full Text Available
Computational prediction of microRNA targets remains a challenging problem. The existing rule-based, data-driven and expression profiling approaches to target prediction are mostly approached from the...Full Text Available
In order to identify novel high value antibacterial targets it is desirable to delineate whether the inactivation of the target enzyme will lead to bacterial death or stasis. This knowledge is particularly...Full Text Available
Computational fluid dynamics(CFD) code FLUENT was used to simulate the thermal hydraulic processes occurring in conceptual design of the accelerator-driven subcritical reactor(ADSR) liquid lead target. The purpose of the analysis is to investigate the thermal hydraulic characteristics of liquid lead as ADSR target material with various target geometries and injection locations of proton beam. In the calculation analysis, the local temperature of the liquid lead target rises to the boiling temperature very rapidly. When the proton beam is injected from the bottom of the target system, the duration time to reach the boiling temperature is longer and the temperature distribution is flatter than other cases.
Experimental and computational investigations were performed in order to better understand the mechanical response of rigid targets with various geometries to the detonation of shallow buried explosives. The motion of the targets was measured by use of high-speed digital video photography. This work involved flat targets, targets that were downwardly convex, and targets that were downwardly concave with explosive charges located at various positions beneath the targets. It was observed that, in general, angled hulls - whether downwardly concave or convex - tended to reduce the amount of momentum imparted to the center of mass of the targets. Computations were performed by use of an arbitrary Langrangian-Eulerian treatment in a nonlinear finite element code. A model based on quasi-static te...
In an effort to develop octahedral metal complexes as chemotherapeutic and diagnostic agents targeted to DNA, it is critical to optimize the properties of their cellular uptake. Appending d-octaarginine...Full Text Available
The design of the absorber blocks for internal and external dumping of the SPS proton beam is discussed. In addition, the external target stations for slow and fast extracted proton beams are described.
... L. Sutton. 2000. Is the aquatic weed hygrophila, Hygrophila polysperma (Polemoniales: Acanthaceae), a suitable target for classical biological ... ...
Nato SCI-12 on Camouflage Evaluation Workshop on Search and Target Acquisition The Netherlands, June 1999. Image Discrimination Models for Object Detection ...
By W. Wayne Scott. Langley Research Center. SUMMARY. Thin- and thick-target bremsstrahlung spectra are presented for electron energies up to 7.0 MeV. ...
We have investigated the nanocrystalline microstructure and the hard magnetic properties of Sm(Co{sub 0.725}Fe{sub 0.1}Cu{sub 0.12}Zr{sub 0.04}B{sub 0.015}){sub 7.4} melt-spun ribbons. The coercivity (H{sub c}) of the as-spun ribbons increased with the wheel surface speed from 2.8kOe for 10m/s to 14.5kOe for 40m/s. The post-annealing of the melt-spun ribbons from 700 to 900 deg. C for 10min did not lead to a substantial increase of H{sub c}. However, after isothermal aging at 820 deg. C and subsequent slow cooling (0.5 deg. C/min) to 120 deg. C, H{sub c} increased from 2.8 to 10.9kOe for 10m/s, while it decreased from 14.5 to 13.5kOe for 40m/s ribbons. The grain size of the melt-spun ribbon reduced with structural transformation from 2:17H (Th{sub 2}Ni{sub 17}-hexagonal type) to 1:7H (TbCu{sub 7}-hexagonal type) as the wheel surface speed was increased. Three-dimensional atom probe analysis showed a boron enriched precipitate at the grain ...
We have investigated the nanocrystalline microstructure and the hard magnetic properties of Sm(Co_0_._7_2_5Fe_0_._1Cu_0_._1_2Zr_0_._0_4B_0_._0_1_5)_7_._4 melt-spun ribbons. The coercivity (H_c) of the as-spun ribbons increased with the wheel surface speed from 2.8kOe for 10m/s to 14.5kOe for 40m/s. The post-annealing of the melt-spun ribbons from 700 to 900 deg. C for 10min did not lead to a substantial increase of H_c. However, after isothermal aging at 820 deg. C and subsequent slow cooling (0.5 deg. C/min) to 120 deg. C, H_c increased from 2.8 to 10.9kOe for 10m/s, while it decreased from 14.5 to 13.5kOe for 40m/s ribbons. The grain size of the melt-spun ribbon reduced with structural transformation from 2:17H (Th_2Ni_1_7-hexagonal type) to 1:7H (TbCu_7-hexagonal type) as the wheel surface speed was increased. Three-dimensional atom probe analysis showed a boron enriched precipitate at the grain boundaries in the as-spun ribbons, which acts ...
In May 1995, the California Public Utilities Commission (CPUC) released two proposals for restructuring the state`s electric power industry. The two proposals follow more than a year of testimony and public comment after the CPUC issued the ``Blue Book`` (CPUC 1994a) on April 20, 1994, which called for retail wheeling to be phased in to all customers over 5 years. The majority proposal, supported by three of the four CPUC commissioners (one seat was vacant when the proposals were released), calls for creating a central pool, or ``poolco``; setting electric prices to reflect true costs of service, or ``real-time pricing``; and allowing parties to negotiate ``contracts for differences`` between the pool price and the contract price. The minority proposal, sponsored by Commissioner Jesse Knight, calls for retail wheeling, or ``direct access,`` and for utilities to divest or spin off their generating assets. This paper presents a summary of the ...
The National Ignition Facility (NIF) is a proposed Department of Energy facility which will contribute to the resolution of important Defense Program and inertial fusion energy issues for energy production in the future. The NIF will consist of a laser system with 192 independent beamlets transported to a target chamber. The target chamber is a multi-purpose structure that provides the interface between the target and the laser optics. The chamber must be capable of achieving moderate vacuum levels in reasonable times; it must remain dimensionally stable within micron tolerances, provide support for the optics, diagnostics, and target positioner; it must minimize the debris from the x-ray and laser light environments; and it must be capable of supporting external neutron shielding. The chamber must also be fabricated from a low neutron activation material. The fusion reaction in the ...
The EU emissions trading scheme (ETS) was launched in 2005 to cap CO2 emissions from large industrial facilities and electricity producers. The European Commission is currently designing the post 2012 EU ETS, as outlined in COM(2008)16. Novel to this system is that a greater part of the rights will be auctioned. Auctioning in general assures a greater deal of efficiency compared to (certain types of) free allocation, lowers the administrative costs and prevents eventual windfall profits. However, auctioning also implies a potential loss of competitiveness for industry. If no international agreement on future climate policies is reached, firms may not be able to pass on the higher costs to their customers and may be faced with a loss in profitability and the threat of import substitution. In any emission trading scheme with an absolute cap, a relocation of production that is not covered by CO2 targets implies an increase in global CO2 emissions. This phenomenon has ...
We proposed a solid and a mercury target concepts through the preliminary conceptual design. To feasible these concepts, analysis and experimental works are being carried out. This paper introduces an outline of present status of target R and D such as heat transfer augmentation experiments for the solid target, mercury flow tests with a loop of maximum flow rate of 15L/min, flow pattern measurements for a cold source moderator etc. as well as preliminary conceptual design works. (author)
Among in uterus exposed A-bomb survivors, fetal week is the most important factor to clarify the effects of A-bomb radiation on developmental process of the fetal brain. The study population of in utero exposed A-bomb survivors has first been established in 1953 in Hiroshima and in 1955 in Nagasaki. According to the estimated DS86 uterus absorption doses, fetal absorption doses obtained from the uterus doses, and intelligence quotient. Various studies on brain damage, including microcephaly, have been undertaken among in uterus exposed A-bomb survivors. Brain development has been shown to be affected during the fetal weeks 8-15 and 16-25. A review of the literature has revealed that 80% of the children with mental retardation and 15 of 18 cases of microcephaly (83%) were exposed in utero during the fetal week 8-15. Among children exposed at the fetal weeks 8-15 and 16-25, average ...
A cohort of singleton black human females exposed to diagnostic x-ray in utero and controls matched by parity, hospital of birth and birthdate have been followed to ages 25 to 30 years in Baltimore, Maryland. The search for possible effects of prenatal irradiation has focused on health, growth, development, and reproductive experience of exposed and control women. This paper reports findings related to reproductive experience. From an original data set of 1458 matched exposed-control pairs of women, questionnaire responses were received from 1109 exposed and 1124 control women including 852 each from pairs in which both the exposed and control woman responded. After careful search for alternative explanations of the findings, the authors concluded that females exposed in utero to low doses of x-ray (probably 1 to 5 rads) had significant increases in their rates ...
In the CERN approach to the design of a neutrino factory, the repetition frequency of the proton beam is high enough to consider stationary solid targets as a viable solution for multi-MW beams. The target consists of high density tantalum spheres of 2 mm diameter which can efficiently be cooled by passing a high mass flow He-gas stream through the voids between the Ta-granules. Very small thermal shocks and stresses will arise in this fine grained structure due to the relatively long burst of 3.3 ms from the SPL-proton linac. In a quadruple target system where each target receives only one quarter of the total beam power of 4 MW, conservative temperature levels and adequate lifetimes of the target are estimated in its very high radiation environment. A conceptual design of the integration of the target into the magnetic horn-pion-collector is presented.
Humans, like other animals, are exposed to a continuous stream of signals, which are dynamic, multimodal, extended, and time varying in nature. This complex input space must be transduced and sampled...Full Text Available
A sample of 30 manganese-exposed foundry workers from two Swedish plants were examined with a partly computerized psychological test battery, comprised of 10 performance tests. Performance of the manganese-exposed workers was compared to that of a matched control group of 60 workers. Matching criteria were age, geographical area, type of work, and the results on a test of verbal comprehension. Performance of the exposed workers was inferior to that of the control group on tests of simple reaction time, digit span, and finger tapping. No correlations were found between performance and the present manganese exposure levels or the number of years employed in manganese work. The results seem to indicate that the present exposure standards for manganese, in Sweden 2.5 mg/m3 and in most other countries 5 mg/m3, are not sufficient to protect workers from negative effects on performance capacity.
Like few other organs, the skin is continuously exposed to multiple exogenous and endogenous stressors. Superimposed on this is the impact of psychological stress on skin physiology and pathology....Full Text Available
OBJECTIVEAdolescent offspring of women with a history of gestational diabetes (GD) were evaluated for their cardiometabolic risks at a mean age of 15 years.RESEARCH...Full Text Available
Flow cytometric techniques were used to measure the cytological and biochemical damage to respiratory tract cells in animals exposed to particulates. Hamsters were exposed to raw and spent oil shale particulates and silica by intratracheal instillation. Exfoliated lung cells were obtained by sacrificing the animals and lavaging the respiratory tract posterior to the trachea with saline. Cell samples were fixed in ethanol and stained with mithramycin for fluorescence analysis of DNA content. DNA content distributions from hamsters exposed to spent oil shale and silica particulates showed atypical changes 28 to 35 days later. Cell counts and total numbers of macrophages, leukocytes, and epithelial cells in the lavage fluid also showed marked changes related to time after exposure.
Palladium chloride films have been found to be useful as ... when suitably prepared palladium chlo- ride films are exposed ... Like the palladium chloride ( PdCl2) ...
Aggregatibacter (Actinobacillus) actinomycetemcomitans is a facultative anaerobic gram-negative bacterium associated with severe forms of periodontitis. A leukotoxin, which belongs...Full Text Available
A field study of 89 refrigerator repairmen was carried out to ascertain whether occupational exposure to fluorocarbons induces cardiac arrhythmia. The concentrations of fluorocarbons in the breathing...Full Text Available
A method and apparatus for determining the condition of tissue or otherwise making chemical identifications includes exposing the sample to a light source, and using a synchronous luminescence system to produce a spectrum that can be analyzed for tissue condition.
Sep 19, 2005 ... within a sealed tube to control the environment to which a sample mounts are better suited to handling the very small crystal is exposed. ...
The contents of this report covers: (1) development of optimal geometries for crowned helical gears; (2) a method for their generation; (3) tooth contact analysis (TCA) computer programs for the analysis of meshing and bearing contact of the crowned helical gears; and (4) modelling and simulation of gear shaft deflection. The developed method for synthesis was used to determine the optimal geometry for a crowned helical pinion surface and was directed to localize the bearing contact and guarantee favorable shape and a low level of transmission errors. Two new methods for generation of the crowned helical pinion surface are proposed. One is based on the application of a tool with a surface of revolution that slightly deviates from a regular cone surface. The tool can be used as a grinding wheel or as a shaver. The other is based on a crowning pinion tooth surface with predesigned transmission errors. The pinion tooth surface can be generated by a computer-controlled ...
A system for real-time neutron radiography of moving objects is described. It comprise a source adapted to generate a continuous uninterrupted series of neutron pulses. Each pulse has a predetermined peak power and duration compatible with the framing times of a real-time video imaging system. A transporter moves an object to be examined to bring sequentially position selected portions of the object in the path of the pulses. Where the object itself has moving components, pulses are sequentially incident on the object. According to any dissimilarities, the object will alter the intensity of the neutrons passing therethrough. In order to record separately the changes in the neutron intensity, for each pulse, an imager is positioned to receive the neutron beam pulses which have been altered by their passage through the object and produce images indicating intensity alterations. A refrigerated beryllium filter can be used to effectively eliminate thermal neutrons from the pulses and ...
A system for real-time neutron radiography of moving objects is described. It comprise a source adapted to generate a continuous uninterrupted series of neutron pulses. Each pulse has a predetermined peak power and duration compatible with the framing times of a real-time video imaging system. A transporter moves an object to be examined to bring sequentially position selected portions of the object in the path of the pulses. Where the object itself has moving components, pulses are sequentially incident on the object. According to any dissimilarities, the object will alter the intensity of the neutrons passing therethrough. In order to record separately the changes in the neutron intensity, for each pulse, an imager is positioned to receive the neutron beam pulses which have been altered by their passage through the object and produce images indicating intensity alterations. A refrigerated beryllium filter can be used to effectively eliminate thermal neutrons from the pulses and ...
Pellet injectors are needed to fuel long pulse tokamak plasmas and other magnetic confinement devices. For this purpose, an apparatus has been developed that forms 1.3-mm-diam pellets of frozen deuterium at a rate of 40 pellets per second and accelerates them to a speed of 1 km/s. Pellets are formed by extruding a billet of solidified deuterium through a 1.3-mm-diam nozzle at a speed of 5 cm/s. The extruding deuterium is chopped with a razor knife, forming 1.3-mm right circular cylinders of solid deuterium. The pellets are accelerated by synchronously injecting them into a high speed rotating arbor containing a guide track, which carries them from a point near the center of rotation to the periphery. The pellets leave the wheel after 150/sup 0/ of rotation at double the tip speed. The centrifuge is formed in the shape of a centrifugal catenary and is constructed of high strength KEVLAR/epoxy composite. This arbon has been spin-tested to a tip speed of 1 km/s.
A series of NHC silver(I), mercury(II) and palladium(II) complexes, [(1,3-diethylbimy)6Ag4I3]I (2), [(1-benzyl-3-picolylbimy)Ag2Br2]n (3), [(1-benzyl-3-picolylbimy)HgI(CH2CN)]2 (4), {[(1-picolyl-3-npropylbimy)2Hg][Hg2I6]}n (5) and [(1,3-dipicolylbimy)PdCl]Cl (6), as well as one anionic complex [1,3-diethylbimidazolium]2[HgI4] (1) (bimy=benzimidazol-2-ylidene), have been prepared and characterized. Interestingly, a wind wheel-like Ag4I3 arrangement in 2 is formed, 1D polymeric chain containing 12-membered macrometallocycles and quadrangle Ag2Br2 units in 3 is generated, and the a-carbon atom of deprotonated acetonitrile ([CH2CN]-) in 4 participates in coordination with mercury(II) atom. In the crystal packings of complexes 1-6, 2D supramolecular layers or 3D supramolecular architectures are...
The performance of the gas-jet transport system coupled to the RIKEN gas-filled recoil ion separator GARIS was investigated using 255No produced in the 238U(22Ne, 5n)255No reaction. Alpha particles of 255No separated with GARIS and transported by the gas-jet system were measured with a rotating wheel apparatus for ? spectrometry under low background condition. The high gas-jet efficiencies of about 75% were independent of the recoil ranges of 255No in the gas-jet chamber. The present results suggest that the GARIS/gas-jet system is a promising tool for the next-generation superheavy element chemistry: (1) the background radioactivities of unwanted reaction products are strongly suppressed, (2) the intense beam is absent in the gas-jet chamber and hence the high gas-jet efficiency is achieved, and (3) the beam-free condition also allows for investigations of new chemical systems. (author)
Considerations were given on typical applications of nylon resin parts to automotive use and their future trends through news topics. GF strengthened nylon resin is used in cylinder head covers substituting aluminum because of advantages in nylon resin of weight reducibility, vibration suppressibility, and noise shielding capability. Radiator tank uses N66GF 30% strengthened nylon in more than 60% of bonnet type passenger cars. Nylon resin is used most in harness connectors installed in locations that require heat resistance. External car parts such as bumpers, fenders, and wheel caps use to some extent nylon resin in the form of strengthened and up-graded polymer alloy. BMW in Germany used in its high-class production cars intake manifolds made of GF strengthened Nylon 66. The majority of engine{prime}s gas intake system parts has been replaced with Nylon blow-formed parts. The resin industry is aiming at developing Nylon resin with aromatic components to use into ...
ATLAS is one of the four experiments which will take place at the LHC, the CERN future protons collider. This accelerator, which should start in 2007, will allow to continue the studies carried out by its predecessors, as the standard model Higgs boson and new physics searches. The very high luminosity -10 fb{sup -1} during the first three functioning years, then 100 fb{sup -1}- and the 14 TeV in the frame center will ease these studies. The Centre de Physique des Particules de Marseille took part in the ATLAS collaboration, taking in charge half of the End-cap electromagnetic calorimeter modules construction. The description of this sub-detector and the construction steps, in particular the electrical tests which allow the stacking validation, are presented in this document. These tests results, obtained for the live first production modules, are analysed. The pre-series module (module 0) performances, obtained with beam tests performed at CERN in 1999, are also presented. The ...
One such agent is the widely used anesthetic, halothane. To study the toxicity of u.v. decomposed halothane, mice were exposed to anesthetic concentrations (1.3%) of non- and u.v.-irradiated halothane in oxygen for 90 min. Halothane sleeping times increased from 14.3 min to 72.5 min. Microsomal mixed function oxidase activity decreased, as shown by prolonged pentobarbital sleeping times 1 day after exposure to halothane and irradiated halothane (54.6 min and 149.1 min, respectively, as compared to a 34.6-min control). Quantitative and qualitative differences were found in the amount of (/sup 14/C)-pentobarbital metabolites excreted by u.v. irradiated halothane-exposed mice compared to either oxygen or non-irradiated halothane-exposed groups. In addition, serum glutamic-oxalacetic transaminase (SGOT) of irradiated halothane-exposed mice increased to 233% of the control values, and serum glutamic-pyruvic ...
When an animal is exposed to a sufficient amount of radiation, there will be changes in many organs of the body, and as a result of either the effects in one particular organ or the interaction of effects in several organs, the animal as a whole will show...
Here we report the first 1H NMR metabolomics studies on excised lungs and bronchoalveolar lavage fluid (BALF) from mice exposed to crystalline silica. High resolution 1H...Full Text Available
Beagle dogs given a single inhalation exposure to "2"3"9Pu(NO_3)_4 are being observed for life-span dose-effect relationships. Over half of the dogs planned for "2"3"9Pu(NO_3)_4 exposure have been exposed and the remaining dogs will be exposed as they reach adult age.
Eight rabbits and 24 guinea-pigs were exposed to a silica dust cloud of about 40,000 pp./ml. (0·3-3·0 μ) and killed at four-weekly intervals up to 30 weeks. The guinea-pigs showed...Full Text Available
The proportion of energy absorbed by the tail of a rat carcass was determined. Male (288 g - 457 g) and female (195 g - 249 g) Sprague-Dawley rat carcasses were exposed to far-field, continuous-wave radiofrequency radiation (RFR). The carcasses were split into two mixed groups: one group was exposed to 700-MHz RFR; and the other, to 350-MHz RFR. Immediately after each exposure, the tail was severed, and the specific absorption rates (SAR) of the tail and body were determined by Dewar flask calorimetry. For example, a 195 g female exposed to 700 MHz yielded SARs of 1.26 and 3.64 mW/g (normalized to 1 nW/cm2 incident power density) for its body and tail, respectively; the tail contributed 6.7% to the total energy absorption. For a 205 g female exposed to 350 MHz, however, the tail contributed 19.0% to the whole-body absorption. Normalized SARs of 0.40 and 4.03 nW/g per mW/cm2 were obtained for the body ...
Pregnant rats in 11d and 16d of their pregnancy were given one-off whole body exposure by "1"3"7Cs #gamma# rays to 0.2, 0.4, 0.9 and 2.0 Gy, respectively. Changes were observed in conditioned drinking response and cerebrum hippocampi cone cell number of the baby rats exposed to the #gamma# rays in different periods of their embryo development. As a result, that pregnant rats exposed to "1"3"7Cs #gamma# rays in different pregnant periods may induce significant decrease in cerebrum hippocampi cone cell number and achieving rate of conditioned drinking response of the babies. The dose-response relationship can be described by Y=a-b log_1_0D. The achieving rate of conditioned drinking response were significantly correlated to cerebrum hippocampi cone cell number in the babies, and the achieving rate of conditioned drinking response of the babies exposed at pregnant 11d was lower than others exposed at ...
PurposeWe conducted a comparative study of Clinical Target Volume (CTV) definition of pelvic lymph nodes by multiple GU radiation oncologists looking at the levels...Full Text Available
To capitalize on the response of tumor cells to ionizing radiation, we developed a controlled-release nanoparticle drug delivery system using a targeting peptide that recognizes a radiation-induced...Full Text Available
The role of IGF-I in the negative regulation of GH expression and release is demonstrated by in vitro and in vivo models; however, the targets and mechanisms of IGF-I...Full Text Available
The technology of gene targeting through homologous recombination has been extremely useful for elucidating gene functions in mice. The application of this technology was thought impossible in the large...Full Text Available
The goal of ultrasonic molecular imaging is the detection of targeted contrast agents bound to receptors on endothelial cells. We propose imaging methods that can distinguish adherent microbubbles...Full Text Available
... detected (and reported) as a by-product of MRM screening (MS/MS) targeted by Law or Rule ... detected (and reported) as a by-product of MRM screening (MS/MS) targeted by Law or Rule ...
The phenomenon of antibiotic resistance has created a need for the development of novel antibiotic classes with non-classical cellular targets. Unfortunately, target-based drug discovery against...Full Text Available
Many genetic processes depend on proteins interacting with specific sequences on DNA. Despite the large excess of nonspecific DNA in the cell, proteins can locate their targets rapidly. After initial...Full Text Available
Peroxisomes, glyoxysomes, glycosomes, and hydrogenosomes have each been classified as microbodies, i.e., subcellular organelles with an electron-dense matrix that is bound by a single membrane. We investigated...Full Text Available
Considering accessibility of the 3′UTR is believed to increase the precision of microRNA target predictions. We show that, contrary to common belief, ranking by the hybridization energy or by...Full Text Available
Histone Arg methylation and Lys acetylation have been found to cooperatively regulate the expression of p53 target genes. Peptidylarginine deiminase 4 (PAD4) is an enzyme that citrullinates...Full Text Available
Operant conditioning techniques were applied to the study of how target fixations are controlled by the probability of signal occurrence. In a standard vigilance setting, gaze at three illuminable...Full Text Available
Cytokinesis in animal and fungal cells utilizes a contractile actomyosin ring (AMR). However, how myosin II is targeted to the division site and promotes AMR assembly, and how the AMR coordinates with...Full Text Available
Purposes1. To determine the optimal pelvic nodal clinical target volume for post-operative treatment of endometrial cancer. 2. To compare the DVH of different treatment planning...Full Text Available
... they assisted in the 2000 attack on the USS Cole? ... List the types of targets that ETA has attacked. ... was at least partially responsible for the attack. ...
... Tanzania, and the attack on the USS COLE. ... vis another has no bearing on the legality of the attack. If the person attacked is a combatant, the use of ...
The production of polarized negative ion beams by collisional pumping is described. Collisional pumping utilizes repeated charge changing collisions in a thick electron-spin-polarized gas or vapor target to form a polarized fast atom beam. The polarized fast atom beam is then partially converted into a polarized negative ion beam in a vapor target. Analysis is presented for a hydrogen beam passing through either a thick polarized H atom target or a thick polarized alkali target. Large polarizations and large currents may be possible.
The production of polarized negative ion beams by ''collisional pumping'' is described. Collisional pumping utilizes repeated charge changing collisions in a thick electron-spin-polarized gas or vapor target to form a polarized fast atom beam. The polarized fast atom beam is then partially converted into a polarized negative ion beam in a vapor target. Analysis is presented for a hydrogen beam passing through either a thick polarized H atom target or a thick polarized alkali target. Large polarizations and large currents may be possible.
While there is growing interest in Real Time Pricing as a competitive tool, its adoption to date has been constrained by wariness on the part of many utilities and many of their customers. That wariness is not misplaced, for Real Time Pricing is not for everyone. In order for both utilities and their customers to benefit, the pricing system must be properly tailored for, and offered to, the appropriate audience. This paper discusses needs for identifying targets, implications of targeting of Real Time Pricing to various types of customers, and implications for design and marketing of such pricing systems. Examples from utility experiences are provided, and recommendations are offered for development of improved targeting of Real Time Pricing.
This paper present the results of a series of calculations made to determine the "2"3"8Pu production potential of several advanced target assembly designs in the Fast Flux Test Facility (FFTF). These calculations show that by using advanced target designs the intimately mix the "2"3"7Np target material with an yttrium hydride moderator, the FFTF has the potential of producing up to 30 kg of high-quality "2"3"8Pu per year.
We apply the framework developed in Target space duality I: general theory. We show that both nonabelian duality and Poisson-Lie duality are examples of the general theory. We propose how the formalism leads to a systematic study of duality by studying few scenarios that lead to open questions in the theory of Lie algebras. We present evidence that there are probably new examples of irreducible target space duality.
The gastrin releasing peptide (GRP) receptor is becoming an increasingly attractive target for development of new radiolabeled peptides with diagnostic and therapeutic potential. The attractiveness of the GRP receptor as a target is based upon the functional expression of GRP receptors in several tumors of neuroendocrine origin including prostate, breast, and small cell lung cancer. This concise review outlines some of the efforts currently underway to develop new GRP receptor specific radiopharmaceuticals by employing a variety of radiometal chelation systems.
This paper illustrates how the techniques developed by the authors for capital cost targeting of mass exchange networks can be applied to determination of capital investment targets for reduction in effluent for existing systems involving mass exchange. The results is an impact diagram which shows the relationship between effluent reduction and capital investment, indicating a region of limiting return on investment as well as the maximum possible reduction in effluent. (au)
In order to facilitate observations of low energy nuclear reactions, a new type recoil mass-separator together with a new gas-jet target system is being developed at the tandem accelerator facility in Kyushu University. The expected mass-resolving power of the separator is 220 for a solid angle of 10 msr and the practical thickness of the gas-jet target will exceed 0.1 atm#centre dot#cm for the light elements of H and He. (author).
A portable fiber optic detector that senses the presence of specific target chemicals by electrostatically attracting the target chemical to an aromatic compound coating on an optical fiber. Attaching the target chemical to the coated fiber reduces the fluorescence so that a photon sensing detector records the reduced light level and activates an appropriate alarm or indicator.
A 16 l liquid parahydrogen target has been developed for a measurement of the parity-violating {gamma}-asymmetry in the capture of polarized cold neutrons on protons in the {rvec n} + p {yields} d + {gamma} reaction by the NPDGamma collaboration. The target system was carefully designed to meet the stringent requirements on systematic effects for the experiment and also to satisfy hydrogen safety requirements. The target was designed to preserve the neutron polarization during neutron scattering on liquid hydrogen (LH{sub 2}), optimize the statistical sensitivity to the {rvec n} + p {yields} d + {gamma} reaction, minimize backgrounds coming from neutron interaction with the beam windows of the target cryostat, minimize LH{sub 2} density fluctuations which can introduce extra noise in the gamma asymmetry signal, and control systematic effects. The target incorporates two mechanical ...
...2010-10-01 2010-10-01 false Energy Policy Act target group certification...Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION...Provisions and Clauses 952.226-73 Energy Policy Act target group...
Rats or mice acutely exposed to high concentrations of ozone show an immediate and significant weight loss, even when allowed free access to food and water. The mechanisms underlying this systemic response to ozone have not been previously elucidated. We have applied the technique of global gene expression analysis to the livers of C57BL mice acutely exposed to ozone. Mice lost up to 14% of their original body weight, with a 42% decrease in total food consumption. We previously had found significant up-regulation of genes encoding proliferative enzymes, proteins related to acute phase reactions and cytoskeletal functions, and other biomarkers of a cachexia-like inflammatory state in lungs of mice exposed to ozone. These results are consistent with a general up-regulation of different gene families responsive to NF-#kappa#B in the lungs of the exposed mice. In the present study, we observed significant ...
Two neutron emesis experiments were conducted at the Armed Forces Radiobiology Research Institute (AFRRI). In both experiments (described as Phase I and Phase II) the radiation dose required to cause emesis in 50% of subjects (ED50) was determined for both neutron reactor and gamma reactor source radiation. Emesis onset, offset and duration times post-exposure are reported. Neutrons were maximized from the reactor by passing the beam through a 15.25 cm (6 in.) thick lead wall to filter out gamma photons. Gamma rays were maximized by thermalizing neutrons in 30.5 cm (12 in.) of water, then absorbing the thermal neutrons in a gadolinium-cadmium shield. In Phase I, 28 dogs were exposed to radiation: 12 were exposed to gamma photons at the rate of 0.69 Gy/min and 16 were exposed to neutrons at 1.2 Gy/min. In Phase II, 58 dogs in 3 groups were exposed to radiation: 19 were exposed in the ...
The effects of exposure to sublethal levels of microwaves were studied. Young albino rats of both sexes were exposed for 60 days to 7.5-GHz microwaves (1.0-KHz square wave modulation, average power 0.6 mW/cm2) for 3 h daily. During and after microwave exposure several physiological parameters were measured in both control and exposed animals. It was found that the animals exposed to microwaves tended to eat and drink less and thus showed a smaller gain in body weight. Some of the hematological parameters and organ weights were also significantly different. It is proposed that a nonspecific stress response due to microwave exposure and mediated through the central nervous system is responsible for the observed physiological changes.
Maldives comprise some of the most characteristic and significant atoll systems, but the meiobenthic assemblages of these islands are still largely unknown. A study on meiofauna was conducted on three Maldivian sandy back-reef platforms differently exposed to stronger westerly monsoons. Clear high energy effects of the waves causing currents and erosions were observed at the completely exposed and isolated offshore reef of Thoddoo Island. Wave energy of medium intensity was confirmed at Rasdhoo by depositional structures (finolhu), while a medium to low energy level was recorded at Gulhi on the basis of the presence of a low sandy bar. The meiofaunal assemblage counted 17 major taxa. Copepods and nematodes were dominant, followed by platyhelminthes and polychaetes. The nematode assemblage ...
Fischer-344 rats were exposed to quartz dusts and to quartz-bearing oil shale dusts in long-term inhalation studies. Aerosol concentrations of 12 mg/m/sup 3/ and 152-176 mg/m/sup 3/ for quartz and shale dusts, respectively, were used in exposure regimens lasting up to two years. Pulmonary fibrosis was observed in most animals surviving beyond 400 days. Adenocarcinomas and epidermoid carcinomas of the lung were observed in animals from all exposure groups, including those exposed to quartz alone. The pulmonary tumors were a late effect, with the earliest lung tumor being observed after 651 days. 13 references, 10 figures, 4 tables.
This study was conducted to investigate the antibacterial effect of BSAP-254 on Bacillus cereus with the induced stress proteins. The BSAP-254 is an antimicrobial peptide isolated from soybean-fermenting bacteria, Bacillus subtilis SC-8. It had a narrow spectrum of activity against B. cereus group. The growth inhibitory effect of BSAP-254 (50??g/mL) reduced the population of B. cereus from >108 to 104 colony-forming units per milliliter within 30?min. In B. cereus exposed to BSAP-254, 14 intracellular proteins were differentially expressed as determined by 2-DE coupled with MS. Of the differentially expressed proteins identified, the stress protein GroEL, which is heat shock protein, was induced in B. cereus exposed to antibacterial peptide.
Experiments were carried out to test the hypothesis that instantaneous daily rates of egg-larval mortality of Pacific herring were higher at two oil-exposed sites than at two other sites not so exposed. Results showed that egg-larval mortality was twice as great in the oil-exposed areas as in the two non-oiled areas. Larval growth rates were also severely affected; they were about half of those measured in populations from other areas of the north Pacific Ocean. A cautionary note was introduced to the effect that the differences in the egg-larval mortality between oiled and control sites may have been influenced by differences in egg dessication, predation, and wave scouring, hence these results should not be construed as conclusive evidence of oil spill damage. 40 refs., 6 figs.
A sensitive and rapid method to evaluate toxic and genotoxic properties of drinking water supplied from Lake Trasimeno (Umbria, Central Italy) was worked out analysing bile in Cyprinus carpio exposed for 20d to lake water treated with 3 different disinfectants, sodium hypochlorite (NaClO), chlorine dioxide (ClO2) and peracetic acid (PAA). Fish were sacrificed at 0, 10 and 20d in order to investigate the time course of these endpoints. An aliquot of bile samples was fractionated by adsorption on C18 silica cartridges and the genotoxic potential of whole bile and of bile fractions was evaluated by the single-cell microgel-electrophoresis (comet) assay on human colonic adenocarcinoma cells (Caco-2). Bile (both whole and fractionated) from specimens exposed to the three disinfectants always sh...
Target materials for inertial fusion energy (IFE) power plant designs might be selected for a wide variety of reasons including wall absorption of driver energy, material opacity, cost and ease of fabrication. While each of these issues are of great importance, target materials should also be selected based upon their safety and environmental (S and E) characteristics. The present work focuses on the recycling, waste management and accident dose characteristics of potential target materials. If target materials are recycled so that the quantity is small, isotopic separation may be economically viable. Therefore, calculations have been completed for all stable isotopes for all elements from lithium to polonium. The results of these calculations are used to identify specific isotopes and elements that are most likely to be offensive as well as those most likely to be acceptable in terms of their S and E ...
Certain allelochemicals of the marine dinoflagellate Alexandrium tamarense cause lysis of a broad spectrum of target protist cells but the lytic mechanism is poorly defined. We first hypothesized that membrane sterols serve as molecular targets of these lytic compounds, and that differences in sterol composition among donor and target cells may cause insensitivity of Alexandrium and sensitivity of targets to lytic compounds. We investigated Ca^2^+ influx after application of lytic fractions to a model cell line PC12 derived from a pheochromocytoma of the rat adrenal medulla to establish how the lytic compounds affect ion flux associated with lysis of target membranes. The lytic compounds increased permeability of the cell membrane for Ca^2^+ ions even during blockade of Ca^2^+ channels wit...
A simple electromagnetic transport system was constructed to identify very rare positrons produced in a powerful laser beam interaction with a target. Testing experiments were carried out with CO[sub 2]-laser (10[sup 12] W/cm[sup 2]) beam pulses ([tau] = 50 ns, f = 0.01 Hz) focused on the copper target, as well as with a 96 MeV alpha-particle beam irradiated carbon target. The results showed that the developed system could be effectively used for positron identification and evaluation of their energy by means of a time-of-flight method. The computerized system to deal with this problem, together with others related to the power laser beam interaction with targets, has been constructed. (orig.).
The modeling methods used to compute the neutron-induced activation of target and near-target materials in the NIF facility are presented. A detailed space and energy description of the neutron environment in the different materials is provided. A new capability has been developed to treat in a general way the activation of debris produced in an operational regime of yield and no-yield experiments. First calculations are addressed to analyze the activity of the debris into the target chamber. The contribution of the different components to activity, interior dose rates, and waste disposal rating (WDR) is determined. The importance of the activation coming from primary irradiation in the target, and from secondary irradiation in debris deposited onto the first wall is assessed. Finally, waste hazards of the activated debris when removed out of the chamber and stored are analyzed. (authors)
Using static Michelson interferometer to get the spectrum information of measurement targets for spectrum identification, under the condition that the interference length is constant, the system can be optimized by BP neural network algorithm for the mixed spectral separation process. Thereby it can realize improving the recognition probability of camouflage target. Collecting the spectrum information in field of view (FOV) by the interferometer and linear array CCD detector, composing the set of mixed spectrum data, with known absorption spectrum of the material as a hidden layer of rules, it used BP neural network to separate the mixed spectrum data. Experiment with different distances, different combinations of mixed background spectrum as the initial data, using steel target (size: 1.5 m x 1.5 m) made of four kinds, the recognition probability of non-camouflage target is about 90% by BP neural ...
In the Fourth Dutch National Environmental Outlook (NMP, abbreviated in Dutch) of the National Institute of Public Health and the Environment (VROM), published in July 1997, possible future developments in the traffic and transport sector in the Netherlands are described for the period 1995-2020 and also evaluates present Dutch policies. NMP-4 also offers possible solutions for expected environmental problems. This report serves as a background document for the traffic and transport sector. With a view to present Dutch policies, the main conclusions drawn from the Outlook are that: (1) the policy targets for car and lorry use for 2010 will not be met, (2) the target for CO2 emissions from road transport for 2010 will not be met, (3) the NOx emission target for 2010 will be met for cars, but not for trucks, (4) the VOC emission target for 2010 will be met for cars, but not for trucks, and (5) the noise ...
The somatically significant dose index can be considered as a measure for the somatic radiation risk to which the population is exposed. Figures are stated for conventional tomography of the skull and thorax. These are compared with the corresponding data for other x-ray examinations, especially computerised tomography. PMID:7134769
This paper reports on the protection of opening that are exposed to the environment in nuclear facilities which presents an almost overwhelming engineering challenge. Intakes and outflows must permit the passage of large volumes of air or water without impeding their flow, and they are often exposed to corrosive salt and chemicals. An intrusion detection sensor that is intended to protect these openings must be capable of operating reliably under environmentally harsh conditions, and at the same time either provide a physical delay barrier or attach to an existing barrier. A new fiber optic sensor technology has now been developed specifically for protecting environmentally exposed openings. This sensor uses a fiber optic cable embedded in a neoprene rubber frame which is reinforced with Kevlar threads or braided steel cable. The sensor is configured in a mesh pattern with openings sufficiently large to permit air or water ...
New visual pigments were formed with 4-hydroxy retinals in isolated vertebrate rod photoreceptors by exposing bleached rods from the tiger salamander, Ambystoma tigrinum, to lipid vesicles containing...Full Text Available
The effect of thiamin on the organ distribution of lead was evaluated in CD-1 mice exposed intragastrically or intraperitoneally to a single dose of lead acetate (100 micrograms) containing 100 microCi...Full Text Available
Thus far there are relatively few data on the risk of leukemia among those who were exposed to external radiation during cleanup operations following the Chornobyl nuclear accident, and results...Full Text Available
Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between...Full Text Available
Background:High-energy fractures of posterior tibial plateau always need surgical treatment. Generally, posterior fragments of these fractures could not be exposed and reduced...Full Text Available
Previous studies have revealed marked differences in the incidence of leukemia between rats and mice exposed to 1,3-butadiene that do not appear to be readily explained on the basis of pharmacokinetics...Full Text Available
Oysters are permanently exposed to various microbes, and their defense system is continuously solicited to prevent accumulation of invading and pathogenic organisms. Therefore, impairment of the animal's...Full Text Available
Anionic microdomains within the aortic smooth muscle cell (SMC) surface glycocalyx represent a potential barrier to the endocytosis of anionic plasma proteins. Cultured SMCs exposed briefly to cationized...Full Text Available
The somatically significant dose index can be considered as a measure for the somatic radiation risk to which the population is exposed. Figures are stated for conventional tomography of the skull and thorax. These are compared with the corresponding data for other X-ray examinations, especially computerised tomography.
The somatically significant dose index can be considered as a measure for the somatic radiation risk to which the population is exposed. Figures are stated for conventional tomography of the skull and thorax. These are compared with the corresponding data for other X-ray examinations, especially computerised tomography. (orig.).
BackgroundPolychlorinated biphenyls (PCBs) may cause immunotoxic effects, but the detailed dose–response relationship and possible vulnerable time windows of exposure are...Full Text Available
Two men reported previously with vitiligo after occupational exposure to hydroquinone monomethyl ether (HMME) have been reviewed after eight years. Repigmentation of significant degree was found in...Full Text Available
and antibody responses of rhesus macaques exposed to the human gammaretrovirus XMRV. J Virol. 2011 May ;85(9):4547-57. Epub 2011 Feb 16 . PubMed Your browsing activity is...
The resistance to destruction of spores of Bacillus subtilis var. niger occluded in crystals of calcium carbonate and exposed to ethylene oxide and moist and dry heat...Full Text Available
Over 250 adults and children were exposed to chlordane when the wooden building surfaces and soil around an apartment complex were sprayed in 1987. Two hundred-sixteen adults had neurobehavioral functions...Full Text Available
RationalePrevious research has shown that rats exposed perinatally to phencyclidine (PCP) exhibited neuroanatomical abnormalities and altered cognition. In addition...Full Text Available
Cell suspension cultures of tomato, Lycopersicon esculentum Mill. cv VFNT-Cherry, produce phytochelatins (poly[γ-glutamylcysteinyl]glycines) when exposed to cadmium. The synthesis...Full Text Available
Peak expiratory flow rate (PEFR) has been measured hourly from waking to sleeping in 29 workers with respiratory symptoms exposed to the fumes of soft soldering fluxes containing colophony (pine resin)....Full Text Available
Locomotive drivers in the steam engine era were exposed to asbestos during their vocational training for two years while training in workshops. Later in their career they had exposure to coal and diesel...Full Text Available
Increased oxidative stress is associated with perinatal asphyxia and respiratory distress in the newborn period. Induction of nuclear factor erythroid 2 p45-related factor (Nrf2) has been shown to decrease...Full Text Available
The possibility has been explored of using a laser scattering technique to detect the imminent onset of rock activity associated with gas outbursts. The instrument described in this paper provides a sensitive, remote and rapid means of passively monitoring micro-seismic activity at the exposed face.
The paper gives a generic idea of the solutions that the neuronal nets contribute to the robotics. The advantages and the inconveniences are exposed that have regarding the conventional techniques. It also describe the more excellent applications as the pursuit of trajectories, the positioning based on images, the force control or of the mobile robots management, among others
BackgroundThe long-term neurotoxicity risks caused by prenatal exposures to pesticides are unclear, but a previous pilot study of Ecuadorian school children suggested that blood...Full Text Available
BackgroundWe have previously reported that low concentrations of cigarette smoke extract induce DNA damage without leading to apoptosis or necrosis in human bronchial epithelial...Full Text Available
This report examines the mortality experience of 527 men who retired from a copper smelter where they were exposed to airborne arsenic trioxide. Urinary arsenic values of all plant employees were determined...Full Text Available
Mitochondrial DNA is constantly exposed to oxidative injury. Due to its location close to the main site of reactive oxygen species, the inner mitochondrial membrane, mtDNA is more susceptible...Full Text Available
The use of infectious pathogens has allowed the detection of the development of synergism between pathogens and ubiquitous environmental chemical contaminants. This synergism has been demonstrated to...Full Text Available
and antibody responses of rhesus macaques exposed to the human gammaretrovirus XMRV. J Virol. 2011 May ;85(9):4547-57. Epub 2011 Feb 16 . PubMed Surgical staging of early...
Rats were exposed to aerosols of "2"3"3U and "2"3"2U nitrate in a study of the long-term biological effects. Preliminary radiation dose estimates show lung > skeleton > kidney in each dose group.
The etiology of alopecia areata (AA), a putative autoimmune disease characterized by sudden hair loss, has remained obscure. It is not understood, how the characteristic inflammatory infiltrate that...Full Text Available
Four of seven human male subjects developed full penile erections when exposed to erotically stimulating motion pictures. Changes in penile size were detected by a mercury strain gauge transducer and...Full Text Available
Mass mortalities among seals and dolphins inhabiting contaminated marine regions have led to speculation about a possible involvement of immunosuppression associated with environmental pollution. To...Full Text Available
Francisella tularensis is a highly infectious bacterium causing the zoonotic disease tularaemia. During its infectious cycle, F. tularensis is not only exposed to the...Full Text Available
BackgroundBerberine is a plant alkaloid that is widely used as an anti-infective in traditional medicine. Escherichia coli exposed to berberine form filaments, suggesting...Full Text Available
Workers from cotton mills were exposed to cotton dust during carding in an experimental cardroom. Cotton from different geographical locations with varying amounts of endotoxin were used. Exposure levels...Full Text Available
DNA double-strand breaks (DSBs) are generally accepted to be the most biologically significant lesion by which ionizing radiation causes cancer and hereditary disease. However, no information on the...Full Text Available
The effect of feedback and materials on perceptual learning was examined in normal hearing listeners exposed to cochlear implant simulations. Generalization was most robust when feedback paired...Full Text Available
Nursing infants may be exposed to lead from breast milk, but relatively few data exist with which to evaluate and quantify this relationship. This route of exposure constitutes a potential infant hazard...Full Text Available
Japanese medaka (Oryzias latipes) embryos exposed to ethanol have developed craniofacial, cardiovascular and skeletal defects which can be compared with the phenotypic features...Full Text Available
Although skin is usually exposed during human exposures to ionizing radiation, there have been no thorough examinations of the transcriptional response of skin fibroblasts and keratinocytes...Full Text Available
A review of the literature on chronic inhalation studies in which rats were exposed to mineral fibres at known fibre number concentrations was undertaken to examine the specific roles of fibre length...Full Text Available
OBJECTIVE: To study cause specific mortality and cancer morbidity in workers exposed to the dust of grinding materials, grinding agents, and stainless steel, especially with regard to a possibly increased...Full Text Available
Pesticide chemicals are an important component of modern agriculture. Through their use, plants and animals are exposed to pesticides directly and indirectly from transport through soil, water, and...Full Text Available
and Antibody Responses of Rhesus Macaques Exposed to the Human Gammaretrovirus XMRV external link, opens in new window J Virol. 2011 May;85(9):4547-57 Detection of CWD...
It has recently been found that many buildings in Taiwan were constructed with radioactively contaminated rebar, which raised great concern among the residents as well as governmental officials. In order to investigate the possible cytogenetic damage to the residents of contaminated buildings, a G-banding method was carried out on the lymphocytes of 30 radiation-exposed individuals from four families and one office building, as well as 15 control individuals from laboratory personnel. The estimated cumulative radiation doses for the exposed people range from 19.63 to 280.50 mSv. Altogether, 13 females and 17 males belonging to the radiation-exposed group, and 7 females and 8 males in the control group, were included in this study. With the exception of one sample, at least 500 metaphase spreads were scored and analyzed for each individual. All the recognizable structural aberrations of chromosomes or chromatids were ...
It has recently been found that many buildings in Taiwan were constructed with radioactively contaminated rebar, which raised great concern among the residents as well as governmental officials. In order to investigate the possible cytogenetic damage to the residents of contaminated buildings, a G-banding method was carried out on the lymphocytes of 30 radiation-exposed individuals from four families and one office building, as well as 15 control individuals from laboratory personnel. The estimated cumulative radiation doses for the exposed people range from 19.63 to 280.50 mSv. Altogether, 13 females and 17 males belonging to the radiation-exposed group, and 7 females and 8 males in the control group, were included in this study. With the exception of one sample, at least 500 metaphase spreads were scored and analyzed for each individual. All the recognizable structural aberrations of chromosomes or chromatids were ...
Top quark is extremely sensitive to non-standard CP violating phases. General strategies for exposing different types of phases at the NLC are outlined. SUSY phase(s) cause PRA in $t\\to Wb$. The transverse polarization of the $\\tau$ in the reaction $t\\to b\\tau\
We evaluated a trial-based approach to conducting functional analyses in classroom settings. Ten students referred for problem behavior were exposed to a series of assessment trials, which were interspersed...Full Text Available
Transmission electron microscopy analysis (TEMA) was used to analyze the bronchoalveolar lavage fluid (BALF) of 262 subjects occupationally exposed (OE) to nonfibrous mineral particles (NFMP) and 42...Full Text Available
Coasts are exposed to chronic or accidental pollutions by hydrocarbons. The aim of this study is to show the importance of the microbial layers (stratified sedimentary systems) in the biodegradation of the hydrocarbons. (A.L.B.)
Carbon steel, copper, zinc and aluminium samples were exposed in different sizes with known ambient parameters in Gran Canaria Island and atmospheric corrosion was investigated. Weight-loss measurements used to determine corrosion damage were complemented...
A survey was conducted at 15 textile plants with dyehouses in western Sweden. Employees with a history of work related rhinitis, asthma, or skin symptoms were offered a clinical and immunological investigation...Full Text Available
BackgroundPatient organisations may be exposed to conflicts of interest and undue influence through pharmaceutical industry (Pharma) donations. We examined advertising and disclosure...Full Text Available
Lycopersicon esculentum Mill. cv Vedettos and Lycopersicon chmielewskii Rick, LA 1028, were exposed to two CO2 concentrations (330 or 900 microliters per...Full Text Available
Previous research has characterized insight as the product of internal processes, and has thus investigated the cognitive and motivational processes that immediately precede it. In this research, however, we investigate whether insight can be catalyzed by a cultural artifact, an external object imbued with learned meaning. Specifically, we exposed participants to an illuminating lightbulb - an iconic image of insight - prior to or during insight problem-solving. Across four studies, exposing participants to an illuminating lightbulb primed concepts associated with achieving an insight, and enhanced insight problem-solving in three different domains (spatial, verbal, and mathematical), but did not enhance general (non-insight) problem-solving.
Inhaled beryllium oxide results in impaired alveolar clearance of inhaled "2"3"9PuO_2 and induces an inflammatory reaction in the lung. However, only one of 184 rats exposed to beryllium developed a lung tumor; none of 128 unexposed rats developed a lung tumor. Fifty-six lung tumors were induced in 181 rats exposed to plutonium. A total of 37 lung tumors were found in 119 rats given combined exposures to beryllium and plutonium. Only in rats given the highest levels of both beryllium and plutonium was there an incidence of lung tumors greater than that seen with exposure to plutonium only.
Retention kinetics and tissue partition coefficients for "8"5Kr were determined in rats exposed to known concentrations of "8"5Kr gas. The tissue partition coefficients were used to calculate the relative tissue radiation dose, assuming exposure conditions equivalent to the maximum permissible concentration in air (MPC)a. The estimated radiation dose was highest in adrenals and body fat, about twice the dose estimated for the next highest tissue, ovaries. Saturation and desaturation curves show that the contents of the large intestines have a prolonged desaturation time compared to other samples analyzed.
Emerging high-power microwave technologies require that bioeffects of exposure to this type of radiation be investigated for health and safety considerations. Disruption of animal behavior is reported to be a sensitive indicator of microwave exposure. Three behavioral tasks were chosen for this initial investigation of exposure to U.S. Air Force high-power microwave emitters. The tasks were: (1) single-trail avoidance, (2) water satiation, and (3) rotarod performance. Exposure to high-power microwave radiation from the USAFSAM peak-power simulator significantly affected the single-trail avoidance task. Neither the single-trail avoidance task nor rotarod performance was affected by the Gypsy emitter. However, animals exposed to 9-kW and 11-kW outputs from the USAFSAM emitter spent significantly less time imbibing water postexposure than sham-exposed animals. The most consistent finding in the animals exposed to the Gypsy ...
Purpose: Various published reports involving intensity-modulated radiotherapy (IMRT) plans developed using automated optimization (inverse planning) have demonstrated highly conformal plans. These reported conformal IMRT plans involve significant target dose inhomogeneity, including both overdosage and underdosage within the target volume. In this study, we demonstrate the development of optimized beamlet IMRT plans that satisfy rigorous dose homogeneity requirements for all target volumes (e.g., #+-#5%), while also sparing the parotids and other normal structures. Methods and Materials: The treatment plans of 15 patients with oropharyngeal cancer who were previously treated with forward-planned multisegmental IMRT were planned again using an automated optimization system developed in-house. The optimization system allows for variable sized beamlets computed using a three-dimensional convolution/superposition dose ...
The production methods for seven radioisotopes, Ga-67, Sr-85, Pd-103, In-111, Tu-167, Hg-197 and Pb-203, by using a classical 1.5m cyclotron in the Institute of Physics and Power Engineering, Obninsk, USSR, are described. At present, more than 50 cyclotrons in different countries are used for the production of radioisotopes applied to medicine. Radioisotopes are produced with the cyclotron in the I.Ph.P.E. in the form of irradiated targets, which are delivered to Moscow radiopharmaceutical factory, where radiopharmaceuticals are produced on the base of these targets. The cyclotron is operated in two regimes providing the acceleration of protons, deuterons and alpha -particles. Two types of target assemblies are used for irradiation, the one is intended for the internal beam, and the other is for the external beam. The reactions used for the production of seven radioisotopes described above, the types of ...
The production methods for seven radioisotopes, Ga-67, Sr-85, Pd-103, In-111, Tm-167, Hg-197 and Pb-203, by using a classical 1.5m cyclotron in the Institute of Physics and Power Engineering, Obninsk, USSR, are described. At present, more than 50 cyclotrons in different countries are used for the production of radioisotopes applied to medicine. Radioisotopes are produced with the cyclotron in the I.Ph.P.E. in the form of irradiated targets, which are delivered to Moscow radiopharmaceutical factory, where radiopharmaceuticals are produced on the base of these targets. The cyclotron is operated in two regimes providing the acceleration of protons, deuterons and alpha -particles. Two types of target assemblies are used for irradiation, the one is intended for the internal beam, and the other is for the external beam. The reactions used for the production of seven radioisotopes described above, the types of ...
This paper proposes a new pattern recognition system employing optical joint transform correlation (JTC) technique which offers a great number of advantages over similar digital techniques, including very fast operation, simple architecture and capability of updating the reference image in real time. The proposed JTC technique incorporates a synthetic discriminant function (SDF) of the target image estimated from different training images to make the pattern recognition performance invariant to noise and distortion. It then involves four different phase-shifted versions of the same target SDF reference image, which are individually joint transform correlated with the given input scene. When the correlation signals are combined, it produces a single cross-correlation peak corresponding to each potential target present in the given input scene. The proposed technique also includes a fringe-adjusted filter to generate a ...
Laser optical pumping can be used to produce polarized alkali atom beams or polarized alkali vapor targets. Polarized alkali atom beams can be converted into polarized alkali ion beams, and polarized alkali vapor targets can be used to produce polarized H/sup -/ or /sup 3/He/sup -/ ion beams. In this paper the authors discuss how the polarized alkali atom beams and polarized alkali vapor targets are used to produce polarized ion beams with emphasis on the production of polarized negative ion beams.
The HARP experiment at CERN is performing extensive measurements of hadron production cross sections and secondary particle yields, in the momentum range 1.5-15 GeV/c, over the full solid angle and using a large set of cryogenic and solid targets. First measurements of hadron production cross-sections in the forward region are reported using an aluminium target 5% of an interaction length thick and a proton beam of 12.9 GeV/c. A preliminary analysis in the large angle region of elastic scattering events produced with the cryogenic hydrogen target at 3 GeV/c beam momentum is also presented.
Carrier-free radionuclides of tungsten and tantalum, "1"7"6","1"7"7W and "1"7"6","1"7"7Ta have been produced by heavy ion activation of holmium target with 97 MeV "1"6O"5"+ beam. Radiochemical separation scheme has been developed to isolate tungsten and tantalum radionuclides from the holmium target matrix. (author)
Carrier-free radioisotopes of tungsten, "1"7"6","1"7"7W, and their corresponding daughter radionuclides "1"7"6","1"7"7Ta, have been produced in holmium target by heavy ion activation with "1"6O"5"+ beam. An attempt has been made to separate these carrier-free radionuclides from bulk holmium target through LLX using cation exchanger HDEHP. (author)
A simple highly efficient procedure has been developed for recovery of thallium radioisotopes from lead and bismuth targets irradiated by 1-GeV protons. The procedure is based on the use of extraction chromatography. The cross-sections have been determined for formation of {sup 200}Pb, {sup 201}Pb, {sup 202m}Pb, and {sup 203}Pb radioisotopes in targets from lead with natural isotopic composition, irradiated by 1-GeV protons.
A simple highly efficient procedure has been developed for recovery of thallium radioisotopes from lead and bismuth targets irradiated by 1-GeV protons. The procedure is based on the use of extraction chromatography. The cross-sections have been determined for formation of "2"0"0Pb, "2"0"1Pb, "2"0"2"mPb, and "2"0"3Pb radioisotopes in targets from lead with natural isotopic composition, irradiated by 1-GeV protons.
The paper presents results of experimental research on the interaction of a pulsed plasma-ion stream with a tungsten (W) target. The pulsed hydrogen plasma was produced within the RPI-IBIS (Multi-Rod Plasma Injector) facility at IPJ in Swierk. Measurements were carried out by means of optical spectroscopy and corpuscular diagnostic techniques. For experiments with the W-target the operational conditions (so-called PID mode) were chosen when a clean hydrogen plasma stream was generated. Attention was paid to the identification of WI and WII spectral lines.
A modified variable structure interacting multiple model (M-VSIMM) estimator for complex hybrid maneuver target tracking is presented. The M-VSIMM could potentially be applied to fire control systems (FCS) used on warships. Target model groups were designed using 3D dimensional dynamic target models. Optimal model group selection logic was proposed, contrary to the activation and termination logic in the original VSIMM. The system will respond faster with optimal model group selection logic. After performing simulations, the tracking performances of the Kalman, ?-?(-?), VDIE, IMM and M-VSIMM filters were compared under various maneuvering conditions.
Preliminary experiments have been performed to investigate the effects of radiative cooling on plasma jets. Thin (3 um - 5 um) conical shells were irradiated with an intense laser, driving jets with velocities > 100 km/s. Through use of different target materials - aluminium, copper and gold - the degree of radiative losses was altered, and their importance for jet collimation investigated. A number of temporally resoved optical diagnostics was used, providing information about the jet evolution. Gold jets were seen to be narrower than those from copper targets, while aluminium targets produced the least collimated flows.
The velocity distribution of electrons ejected close to the forward direction by 0.8-2 MeV/A ions traversing various solid targets, including a Au monocrystal, is measured in coincidence with emerging charge-selected ions. The velocity spectrum is observed to be independent of outgoing projectile velocity and charge state for polycrystalline targets. Measurements on the Au crystal under channeling conditions show dependences on final charge state, and are tentatively explained by assuming that the main contribution to the production yield comes from the non-channeled fraction of the ions. A simple model for the creation of the forward-ejected electrons is proposed, which accounts for most of the experimental findings.
A computer-assisted rotation and stationary conformation radiotherapy system with overrunning multileaf collimators has been developed. This system can produce any shape of target volume, including a number of target areas outside the axis of the rotation, regardless of the location of the axis at 360"0 rotation irradiation. In addition, by changing the dose rate and deleting a partial region within a field, multiple stationary irradiation can produce more homogeneous target volumes - thus avoiding excessive irradiation to critical organs - than the rotation technique. (orig.).
The centroid and envelope dynamics of a high-intensity charged particle beam are investigated as a beam smoothing technique to achieve uniform illumination over a suitably chosen region of the target for applications to ion-beam-driven high energy density physics and heavy ion fusion. The motion of the beam centroid projected onto the target follows a smooth pattern to achieve the desired illumination, for improved stability properties during the beam-target interaction. The centroid dynamics is controlled by an oscillating "wobbler", a set of electrically-biased plates driven by RF voltage. __________________________________________________
Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes...Full Text Available
Several different aspects of the influence of the target backing on in-beam electron spectra following compound nuclear reactions induced by accelerated ions at tandem energies irradiating backed targets are discussed in detail. This discussion is illustrated by a few typical examples, such as "1"2C"5"+ and "3"1P"1"0"+ beams at 4 MeV/u bombarding Sn(+Be), Sn(+Au), Pb(+C) backed targets. Moreover, the relative influence of electron backscattering, electron Doppler shift and Doppler broadening as well as #delta#-electron emission on the low energy electron spectra (E_e#<=#100 keV) obtained under such conditions are investigated in the frame of the available experimental data. (orig.).
Using the complex Kohn method, we have calculated variational values of phase shifts and the annihilation parameter, Z_{eff}, for the elastic scattering of positrons by molecular hydrogen. Our results are sensitive to small changes in the accuracy of the wave function representing the target hydrogen molecule. We have developed a systematic approach to demonstrate that, at low positron energies, there are particular forms of the Kohn trial wave function for which the results of variational calculations are not reliable, even when the target wave function accounts for as much as 96.8% of the correlation energy of H_{2}. We find that reliable results can be recovered if our calculations are extended to admit more sophisticated target wave functions accounting for 99.7% of the correlation energy. Remaining discrepancies between theory and experiment are briefly discussed.
Axon outgrowth and guidance to the proper target requires the coordination of filamentous (F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape change and locomotion....Full Text Available
We develop a systematic framework for studying target space duality at the classical level. We show that target space duality between manifolds M and M-tilde arises because of the existence of a very special symplectic manifold. This manifold locally looks like MxM-tilde and admits a double fibration. We analyze the local geometric requirements necessary for target space duality and prove that both manifolds must admit flat orthogonal connections. We show how abelian duality, nonabelian duality and Poisson-Lie duality are all special cases of a more general framework. As an example we exhibit new (nonlinear) dualities in the case M=M-tilde=R{sup n}.
This report discusses the experimental setup of experiment 814 at Brookhaven AGS. This experiment involves the collision of silicon ions with target nuclei. The detector systems are discussed primarily. (LSP)
The oviduct is an exquisitely designed organ that functions in picking-up ovulated oocytes, transporting gametes in opposite directions to the site of fertilization, providing a suitable environment...Full Text Available
Motivation: Automatic recognition of cell identities is critical for quantitative measurement, targeting and manipulation of cells of model animals at single-cell resolution. It has been...Full Text Available
The success of monoclonal antibodies in clinical practice is dependent on good design. Finding a suitable target is the most important part as other properties of the antibody can be altered by genetic...Full Text Available
Many existing agents for diabetes therapy are unable to restore or maintain normal glucose homeostasis or prevent the eventual emergence of hyperglycemia-related complication. Therefore, agents based on novel mechanisms are sought to complement and extend the current therapeutic approaches. Based on the initial paper research, we focused on active STAT3 as an attractive pharmacological target for type 2 diabetes. The subsequent text mining with a unique query to identify suppressors but not activators of STAT3 revealed the ERK2/STAT3 pathway as a novel diabetes target. The description of ERK2 inhibitors as diabetes target had not been found in our text mining research at present. The mechanism-based peptide inhibitor for ERK2 was identified using the knowledge of the KIM sequence, which ha...
Nov 21, 2003... for the European Space Agency's Automated Transport Vehicle, a new, uncrewed station cargo vehicle targeted for launch late next year. ...
Congestive heart failure (CHF) is a leading cause of morbidity and mortality. CHF is marked by atrial and ventricular enlargement and reduced cardiac contractility, as well as an association...Full Text Available
PurposeClinical trials have commenced to evaluate the feasibility of targeting malignant gliomas with genetically engineered cytolytic T-cells (CTLs) delivered directly...Full Text Available
Chaperones (stress proteins) are essential proteins to help the formation and maintenance of the proper conformation of other proteins and to promote cell survival after a large variety of environmental...Full Text Available
In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences...Full Text Available
The eye is an easily accessible, highly compartmentalised and immune-privileged organ that offers unique advantages as a gene therapy target. Significant advancements have been made in understanding...Full Text Available
An application that provides a flexible and easy to use interface to the GAMMA spectral simulation package is described that is targeted at investigations using in vivo MR spectroscopic methods....Full Text Available
The potential of radiolabelled phenylpiperazines as agents for the detection and therapy of tumours of neural crest origin was evaluated by in vitro pharmacological studies with human neuroblastoma...Full Text Available
This letter reports a study designed to measure the benefits of voicing in the recognition of concurrent syllables. The target and distracter syllables were either voiced or whispered, producing...Full Text Available
Dynamic clamp is a powerful method that allows the introduction of artificial electrical components into target cells to simulate ionic conductances and synaptic inputs. This method is based...Full Text Available
... defense's weapons are Space-based kinetic-kill vehicles ... I ti I obtained by dividing the weapons as ... of the optimal weapon-arge assigntments and ...
... In the Proceedings of INTC 2003, we studied charging effects on target coverage during electrospinning (16). ... of Fibers from Electrospinning of ...
The biosynthesis of insect juvenile hormone (JH) and its neuroendocrine control are attractive targets for chemical control of insect pests and vectors of disease. To facilitate the molecular...Full Text Available
The pleiotropic actions of neuromodulators on pre- and postsynaptic targets present challenges to disentangling the mechanisms underlying regulation of synaptic transmission. Within the striatum,...Full Text Available
BackgroundThe metagenomic analysis of microbial communities holds the potential to improve our understanding of the role of microbes in clinical conditions. Recent, dramatic improvements...Full Text Available
The immune system plays a crucial role in maintaining health; however, accumulating evidence indicates that this system can be the target for immunotoxic effects caused by a variety of chemicals including...Full Text Available
BackgroundAmino-terminal signal peptides (SPs) are short regions that guide the targeting of secretory proteins to the correct subcellular compartments in the cell. They are cleaved...Full Text Available
There is presently considerable interest in wear resistant coatings produced using closed field unbalanced magnetron sputtering technology. For example, layered films of diamond-like carbon (DLC) with tungsten or titanium additions have been widely reported. The benefit is that the mechanical properties are enhanced (e.g. giving greater toughness); also it is possible to control the stress state and enhance adhesion. Here we report the further development of this concept by the addition of TiN, TiCN and TiC layers in DLC-based composites, utilizing an additional source of electrons in the vicinity of substrate to enhance ionisation of the plasma and increase coating density. Composite coatings of ceramics TiN, TiC{sub x}N{sub y}, TiC, CrN, TiCrN, TiCrCN, TiCrC, metal doped Ti{sub x%}-DLC and their combinations were deposited on 316 stainless steel substrates. The mass flow of reactive gases into the chamber was controlled using plasma optical emission monitoring to achieve the desired ...
The Infrared Camera (IRC) is one of the scientific focal plane instruments on board the ASTRO-F infrared astronomical satellite. The IRC is designed for wide field imaging and slit-less spectroscopic observations at near- and mid-infrared wavelengths. The IRC consists of three channels; NIR, MIR-S and MIR-L, each of which covers wavelengths of 2-5, 5-12 and 12-26 micron, respectively. All channels adopt compact refractive optical designs. Large format array detectors (a InSb 512 x 412 array and two Si:As IBC 256 x 256 arrays) are employed. Each channel has 10 x 10 arcminutes wide FOV with diffraction-limited angular resolution of 70cm aperture of the liquid helium cooled telescope at wavelengths over 5 micron. A 6-position filter wheel is placed at the aperture stop in each channel, and has three band-pass filters, two grisms/prisms and a mask for dark current measurements. The 5 sigma sensitivity of one pointed observation is estimated to be 2, 11 and 62 micro-Jy ...
The topics of these short lectures on the subject of cyclic stress were: Microstructural mechanisms of damage accumulation under a multistage cyclic stress until incipient cracking; influence of surface decarbonizing phenomena on the failure behaviour of steel construction parts subjected to cyclic stress; thermocyclic fatigue of pipe samples of austenitic steel 1.4436; studies on surface structuring, microstructure and fatigue in LCF area. The short lectures on effects of quasi-static and creep stress were: Shear fracture in AlMg alloys as a result of local plastic instability; study of formation and growth of pores for an early recognition of damage and the course of damage in heat-resistant steels under creep test; experimental and numeric studies of the infuence of the microstructure on the course of damage during shear fractures of steel; numerical modelling of ductile fractures on the basis of micromechanical models. Under the topic of tribological stress the following lectures ...
The Chinese government has enacted policies to promote alternative vehicle fuels (AVFs) and alternative fuel vehicles (AFVs), including city bus fleets. The life cycle (LC), energy savings (ES) and GHG reduction (GR) profiles of AVFs/AFVs are critical to those policy decisions. The well-to-wheels module of the Tsinghua-CA3EM model is employed to investigate actual performance data. Compared with conventional buses, AFVs offer differences in performance in terms of both ES and GR. Only half of the AFVs analyzed demonstrate dual benefits. However, all non-oil/gas pathways can substitute oil/gas with coal. Current policies seek to promote technology improvements and market creation initiatives within the guiding framework of national-level diversification and district-level uniformity. Combined with their actual LC behavior and in keeping with near- and long-term strategies, integrated policies should seek to (1) apply hybrid electric technology to diesel buses; (2) ...
Objectives: We have previously shown that chronic exposure to ambient fine particulate matter (less than 2.5 ?m in aerodynamic diameter, PM(2.5)) pollution in conjunction with high-fat diet induces insulin resistance through alterations in inflammatory pathways. In this study we evaluated the effects of PM(2.5) exposure over a substantive duration of a rodent's lifespan and focused on the impact of long-term exposure on adipose structure and function.Methods and Results: C57BL/6 mice were exposed to PM(2.5) or filtered air (FA) (6 hours/day, 5 days/week) for duration of 10 months in Columbus, OH. At the end of the exposure, PM(2.5)-exposed mice demonstrated insulin resistance (IR) and a decrease in glucose tolerance compared with the FA-exposed group. Although there were no significant differences in circulating cytokines between PM(2.5)- and FA-exposed groups, circulating adiponectin and leptin were ...
By polymerase chain reaction with arbitrary primer (AP-PCR), the possibility of transmission of genome instability to somatic cells of the offspring (F_1 generation) from male parents of mice exposed to chronic low-dose #gamma#-radiation was studied. Male mice 15 days after exposure to 10-50 cGy were mated with unirradiated females. Biopsies were taken from tale tips of two month-old mice progeny for DNA separation. Primer in the AP-PCR was 20-mer oligonucleotide flanking the micro-satellite locus Atplb2 on chromosome 11 of the mouse. Comparative analysis of individual fingerprints of AP-PCR products on DNA-templates from the offspring of irradiated and unirradiated male mice revealed an increased variability of micro-satellite-associated sequences in the genome of the offspring of males exposed to 25 and 50 cGy. DNA-fingerprints of the offspring of male mice exposed to chronic irradiation doses 10 and 25 cGy. 15 days ...
A transplant experiment was conducted to determine whether standard metabolic rate (SMR) of a freshwater shrimp (Palaeomonetes paludosus) would be affected by exposure to trace element-enriched coal combustion waste (coal ash). Shrimp were transplanted into replicate cages in a coal ash-polluted site and a reference site for 8 months. The coal ash-polluted site was characterized by elevated sediment concentrations of As, Cd, Cr, Cu, Ni, Pb and Se compared to sediments in the reference site. After 8 months in the study sites, shrimp in the polluted site appeared to have accumulated As, Cd and Se from the habitat, but there were on differences in survival between the study sites. However, mean SMR of shrimp (measured as O{sub 2} consumption at rest) held in the polluted site was 51% higher than mean SMR of shrimp held in the reference site. The elevation in SMR indicates that the energetic costs of maintenance are greater for shrimp chronically exposed to the ...
The objective of this research project is to investigate the biocompatibility of N-isopropylacrylamide (NIPAAm) monomers and poly(N-isopropylacrylamide) (PNIPAAm) nanoparticles in vitro. PNIPAAm nanoparticles of different sizes were synthesized and characterized by transmission electron microscopy and dynamic light scattering. Cytotoxicity studies using MTS assays were conducted on fibroblasts, smooth muscle cells, and endothelial cells. In addition, the concentration of NIPAAm monomers remaining on PNIPAAm nanoparticles was determined using bromination and spectrophotometry. The cytotoxicity results did not show a significant difference in cell survival when cells were exposed to different particle sizes (100, 300, and 500 nm). Dose studies showed that all three cell types exposed to 100 nm PNIPAAm nanoparticles at concentrations less than or equal to 5 mg/mL were compatible, while cells exposed to NIPAAm monomers ...
Carbon fibre composite (CFC) was irradiated by hot plasma streams at plasma gun facility MK-200UG. The CFC targets were tested by plasma loads relevant to Edge Localized Modes (ELM) and mitigated disruptions in ITER. Onset condition of CFC evaporation and properties of evaporated carbon were studied by use of infrared pyrometry and visible spectroscopy.
RNA interference (RNAi) is an effective tool for studying gene function in oocytes, but no studies have targeted somatic cells of primary cultured cumulus cell-oocyte complexes (COCs). This...Full Text Available
Targeted genome capture combined with next-generation sequencing was used to analyze 2.9 Mb of the DFNB79 interval on chromosome 9q34.3, which includes 108 candidate genes. Genomic...Full Text Available
We review the physics of structure functions at low Q{sup 2}, focusing on the phenomenon of quark-hadron duality and the resonance-scaling transition, both phenomenologically and in the context of quark models. We also present a new implementation of target mass corrections to nucleon structure functions which, unlike existing treatments, has the correct kinematic threshold behavior at finite Q{sup 2} in the x -> 1 limit.
Production of lead-203 by proton irradiation of bismuth metal has been investigated as a replacement method for commercially available lead-203. Targets of bismuth metal (0.1 cm thick) were irradiated for periods of 1-3 hours with 90 MeV protons. After processing of the target, the estimated yield of lead-2-3 was 30 millicuries/microamp.
The NREL Sensitized Solar Cell (SSC) Core Program supports the Solar America Initiative by: (1) targeting new devices and processes for commercialization by 2015 that are less expensive, more efficient, highly reliable, and environmentally benign; (2) collaborating with DOE OS/BES to conduct basic research targeting breakthroughs in key areas, such as ultra-high efficiency and/or ultra-low cost materials and devices.
We have developed a set of modeled nuclear reaction cross sections for use in radiochemical diagnostics. Systematics for the input parameters required by the Hauser-Feshbach statistical model were developed and used to calculate neutron induced nuclear reaction cross sections for targets ranging from osmium (Z = 76) to gold (Z = 79). Of particular interest are the cross sections on Ir and Au including reactions on isomeric targets.
LEW anti-DA kidney and DA anti-LEW kidney sera were assayed using an indirect 125I anti-immunoglobulin-binding assay with kidney homogenate as target. This allowed the full spectrum of antibodies to...Full Text Available
The herbicide atrazine is a known immunotoxicant and an inhibitor of human natural killer (NK) cell lytic function. The precise changes in NK cell lytic function following atrazine exposure have not been fully elucidated. The current study identifies the point at which atrazine exerts its affect on the stepwise process of human NK cell-mediated lyses of the K562 target cell line. Using intracellular staining of human peripheral blood lymphocytes, it was determined that a 24-h in vitro exposure to atrazine did not decrease the level of NK cell lytic proteins granzyme A, granzyme B or perforin. Thus, it was hypothesized that atrazine exposure was inhibiting the ability of the NK cells to bind to the target cell and subsequently inhibit the release of lytic protein from the NK cell. To test this hypothesis, flow cytometry and fluorescent microscopy were employed to analyze NK cell-target cell co-cultures following atrazine ...
Gene silencing is a useful technique for elucidating biological function of genes by knocking down their expression. A recently developed artificial microRNAs (amiRNAs) exploits an endogenous...Full Text Available
An electron accelerator unit is described for electron beam therapy, comprising: a source of an electron beam; means for finally directing at least a portion of the beam to a therapy site, the directing means being mechanically independent of, and electrically isolated from, the source, and having a target area; and means for aligning the source with the directing means, the aligning means comprising means for projecting at least one beam of light from the source toward the target area.
An electron accelerator unit is described for electron beam therapy, comprising: a source of an electron beam; means for finally directing at least a portion of the beam to a therapy site, the directing means being mechanically independent of, and electrically isolated from, the source, and having a target area; and means for aligning the source with the directing means, the aligning means comprising means for projecting at least one beam of light from the source toward the target area.
Measurements of the double-electron-capture process in which a positive ion of iodine becomes a negative ion in a single collision with a magnesium atom are reported between 20 and 90 keV. The cross section is comparable to that for the rare gases and not as large as might be expected from a two-valence-electron atom. This process is probably insignificant in the production of negative ion beams using a magnesium-vapor target.
PNNL, with cofunding from the Bonneville Power Administration (BPA) and Building Technologies Program, conducted a research and development activity targeted at addressing the energy efficiency goals targeted in the BPA roadmap. PNNL investigated an integrated heating, ventilation and air conditioning (HVAC) system option referred to as the low-lift cooling system that potentially offers an increase in HVAC energy performance relative to ASHRAE Standard 90.1-2004.
A new proprietary de novo peptide design technique generated ten 15-residue peptides targeting and containing the leading nontransmembrane hydrophobic autocorrelation wavelengths, “modes”,...Full Text Available
BACKGROUND:Despite an increasing body of evidence on the benefit of lowering elevated levels of low-density lipoprotein cholesterol (LDL-C), there is still considerable concern that...Full Text Available
MicroRNAs are short (∼22 nucleotides) noncoding RNAs that regulate the stability and translation of mRNA targets. A number of computational algorithms have been developed to help predict which...Full Text Available
During the weekend of September 2--3, 1984, a part of the wooden spillway for Steed Pond gave way and the pond slowly drained. Consideration is being given to leaving Steed Pond dry. Steed Pond has accumulated some of the uranium discharged from 300 Area operations and past surveys have shown that the uranium concentration in the sediments ranges between 20 and 531 pCi/gm. The recently completed aerial survey of the exposed area of Steed Pond showed that the uranium was widely spread in the sediments of Steed Pond. Until ground cover is established over the exposed pond sediments, they will be subject to erosion. As much as 90 tons of sediment could be eroded from the exposed sediments in Steed Pond the first year, but the erosion could be reduced to 5--15 tons by establishing a ground cover such as rye grass. Only about 40% of the eroded sediment would be delivered to Upper Three Runs Creek, because most of the eroded ...
The radioprotective effects of Liv.52 on tissue-reduced glutathione (GSH) levels were studied in rats. Adult female Sprague Dawley rats were exposed to whole body gamma radiation of 4 Gy and 8 Gy. Prior to radiation exposure, Liv.52 was fed, one ml per rat, daily for 15 days. Three days after radiation exposure, reduced glutathione levels in the liver, spleen, kidney and blood were studied. Liv.52 was beneficial in restoring the spleen weight to body weigh t ratio in the animals of the 4 Gy group. In the spleen and liver, Liv.52 helped to restore reduced glutathione in sub-lethally exposed rats. Blood-reduced glutathione was found to be normal in both groups of experimental rats who received Liv.52. The above results exhibit the radioprotective effects of Liv.52 in relation to tissue-reduced glutathione in experimental rats exposed to sub-lethal doses of radiation. (author). 3 tabs., 25 refs.
Specimen strips of pure alpha titanium and beta titanium alloy were exposed to a range of up to 46 deuterium plasma discharges in the Princeton Large Torus Tokamak (PLT) under simulated first wall conditions, and the amount of trapped deuterium in these specimens was measured, using carbon as a calibration standard for trapping. The Deuterium Nuclear Microprobe was used to study the total trapped deuterium and the deuterium depth distribution in the exposed materials before and after annealing at 373 and 423"0K. The Scanning Auger Microprobe was used to identify the effects of surface impurities on the deuterium distribution. Results indicate that about 20 to 40% of the incident deuterium was trapped by the surface and about 90% of the trapped deuterium remained in a 20A carbonaceous film deposited during plasma exposure. Annealing resulted in a gradual loss from the film. These results indicate the importance of impurity film formation which ...
For the purpose of risk estimates from radiation carcinogenesis including leukemogenesis and radiation genetic effects, the biological significant dose is not the tissue kerma in air but the absorbed dose in organ or tissue with respect to carcinogenic and leukemogenic effects or genetic effects. In order to estimate organ or tissue dose from the tissue kerma in air, a ratio of the organ or tissue dose to the tissue kerma in air for survivors in Hiroshima and Nagasaki was calculated with the aid of the Snyder's mathematical phantoms constructed so as to simulate the body shape of survivors aged 5, 10 years old and adult at the time of atomic bomb detonations. The ratios were corrected for the angular distribution of atomic bomb radiations, assuming an anisotropic angular distribution for the survivors exposed to the atomic bombs in open air and the isotropic distribution for the survivors incide a Japanese house or other structures. The resultant ratios are ...
Radon exposure assessment in case-control studies on radon and lung cancer is generally based on contemporary radon concentration measurements, which can be affected by significant changes in the building structures or in living habits. Another method to estimate the radon exposure of the subjects is the recently developed retrospective dosimetry technique based on the {sup 210}Po surface activity from glass objects. In order to compare the results obtained by the two methods, a study has been carried out in a sample of 26 dwellings in Rome, with radon concentration values ranging from 28 to 623 Bq m{sup -3}. Retrospective detectors based on CR-39 and LR 115 were exposed on 50 glass objects in bedrooms and living rooms. The correlation factor between the two sets of data, after removing six extreme values, is 0.67, which is similar to results obtained in other validation studies of similar sample size. The correlation increases to 0.83 if the 21 objects ...
The in situ assembly states of the glucose transport carrier protein in the plasma membrane and in the intracellular (microsomal) storage pool of rat adipocytes were assessed by studying radiation-induced inactivation of the D-glucose-sensitive cytochalasin B binding activities. High energy radiation inactivated the glucose-sensitive cytochalasin B binding of each of these membrane preparations by reducing the total number of the binding sites without affecting the dissociation constant. The reduction in total number of binding sites was analyzed as a function of radiation dose based on target theory, from which a radiation-sensitive mass (target size) was calculated. When the plasma membranes of insulin-treated adipocytes were used, a target size of approximately 58,000 daltons was obtained. For adipocyte microsomal membranes, we obtained target sizes of approximately 112,000 and 109,000 daltons prior ...
The ratio of the proton's electric to magnetic form factor, G{sub E}/G{sub M}, can be extracted in elastic electron-proton scattering by measuring cross sections, beam-target asymmetry, or recoil polarization. Separate determinations of G{sub E}/G{sub M} by cross sections and recoil polarization observables disagree for Q{sup 2}>1 (GeV/c){sup 2}. Measurement by a third technique might uncover an unknown systematic error in either of the previous measurements. The beam-target asymmetry has been measured for elastic electron-proton scattering at Q{sup 2} = 1.51 (GeV/c){sup 2} for target spin orientation aligned perpendicular to the beam momentum direction. This is the largest Q{sup 2} at which G{sub E}/G{sub M} has been determined by a beam-target asymmetry experiment. The result, {mu}G{sub E}/G{sub M}=0.884{+-}0.027{+-}0.029, is compared to previous world data.
Target recognition requires the ability to distinguish targets from non-targets, a capability called one-class generalization. To function as a one-class classifier, a neural network must have three types of generalization: within-class, between-class, and out-of-class. We discuss these three types of generalization and identify neural network architectures that meet these requirements. We have applied our one-class classifier ideas to the problem of automatic target recognition in synthetic aperture radar. We have compared three neural network algorithms: Carpenter and Grossberg`s algorithmic version of the Adaptive Resonance Theory (ART-2A), Kohonen`s Learning Vector Quantization (LVQ), and Reilly and Cooper`s Restricted Columb Energy network (RCE). The ART 2-A neural network has given the best results, with 100% within-class, and out-of-class generalization. Experiments show that the network`s ...
Target recognition requires the ability to distinguish targets from non-targets, a capability called one-class generalization. Many neural network pattern classifiers fail as one-class classifiers because they use open decision boundaries. To function as one-class classifier, a neural network must have three types of generalization: within-class, between-class, and out-of-class. We discuss these three types of generalization and identify neural network architectures that meet these requirements. We have applied our one-class classifier ideas to the problem of automatic target recognition in synthetic aperture radar. We have compared three neural network algorithms: Carpenter and Grossberg`s algorithmic version of the Adaptive Resonance Theory (ART-2A), Kohonen`s Learning Vector Quantization (LVQ), and Reilly and Cooper`s Restricted Coulomb Energy network (RCE). The ART 2-A neural network gives the best ...
Obtained experimental data on integral cross sections (ICS) of inelastic scattering of 50.5 MeV #alpha# particles with the excitation of "6","7Li, "9Be, "1"2","1"3C, "1"4C, "1"4N, "2"0Ne, "2"4Mg, "2"8Si nucleus low-lying energy levels are discussed. Regularities, detected in the behaviour of ICS forward scattering for 20-90 deg angles and backscattering for 90-160 deg angles for the target-nucleus under investigation are considered. Effect of reaction open channel number on #alpha#-particle scattering ICS where n,p,d- and #alpha#-channels were considered as the main channels for all the target-nuclei, is discussed. Dependence of #alpha#-particle scattering ICS on the target-nucleus level excitation energy and dependences of reaction open channel number on the channel spin, calculated for 50.5 MeV #alpha# particles and different target nuclei are shown in the diagrams. It is noted that the observed ...
Background: the authors report on the conception and first clinical application of a donut-shaped high-dose configuration for proton therapy (PT). This approach allows one to intensify target volume dose coverage for targets encompassing a critical, dose-limiting structure - like here, the cauda equina -, whilst delivering minimal dose to other healthy structures surrounding the target, thereby reducing the integral dose. Methods and results: intensity-modulated PT methods (IMPT) for spot scanning were applied to create and deliver a donut-shaped high-dose configuration with protons, allowing treating > 75% of the target with at least 95% of the prescribed dose of 72.8 CGE, whilst restricting dose to the cauda equina to 60-65 CGE. Integral dose was lower by a factor of 3.3 as compared to intensity-modulated radiotherapy with photons (IMXT). Conclusion: IMPT and spot scanning technology allow a ...
Background: the authors report on the conception and first clinical application of a donut-shaped high-dose configuration for proton therapy (PT). This approach allows one to intensify target volume dose coverage for targets encompassing a critical, dose-limiting structure - like here, the cauda equina -, whilst delivering minimal dose to other healthy structures surrounding the target, thereby reducing the integral dose. Methods and results: intensity-modulated PT methods (IMPT) for spot scanning were applied to create and deliver a donut-shaped high-dose configuration with protons, allowing treating > 75% of the target with at least 95% of the prescribed dose of 72.8 CGE, whilst restricting dose to the cauda equina to 60-65 CGE. Integral dose was lower by a factor of 3.3 as compared to intensity-modulated radiotherapy with photons (IMXT). Conclusion: IMPT and spot scanning technology allow a ...
A new series of anatase TiO2 hollow structures were prepared by a facile hydrothermal process. When the hydrothermal time was increased from 20min to 72h, the resulting TiO2 solid spheres gradually transformed into TiO2 hollow spheres with higher surface crystallinity and exposed {001} facets. The as-prepared TiO2-72h sample exhibited the highest activity comparing to other TiO2-based samples and commercial product Degussa P-25 towards the selective photocatalytic oxidation of toluene to benzaldehyde. Such great photocatalytic performance was mainly attributed to enhanced UV-adsorption and better charge separation efficiency due to higher surface crystallinity of TiO2-72h.
Normally, concrete technologists attribute salt weathering, salt crystallization or physical attack to the deterioration of concrete that is partially exposed to sulfate environment. However, there are few convincing evidences supporting this view. The purpose of this paper is to check by means of extensive micro-analysis if traces of sulfate crystals are present in the paste. This would enable to verify in a direct way whether salt weathering really causes cement paste damage or not.In this research, cement paste and cement?fly ash paste specimens were partially exposed to sodium sulfate and magnesium sulfates solution under a constant storage condition (20 ? 2 ?C, and 60 ? 5% RH) and a sharply fluctuating environment (40 ? 2 ?C and 35 ? 5% RH for 24 h, then 10 ? 1 ?C and 85 ? 5% RH, also...
Laboratory studies have been carried out to determine the toxicity of methiocarb pellets to wild trapped wood mice in order to provide some background data prior to any further evaluation of hazard in the field. In this study, wood mice were exposed to dry and to dampened methiocarb pellets in order to reproduce field trial application conditions. Field observations of methiocarb pellets indicate that the physical character changes under dry and wet weather conditions. This may affect their relative attractiveness and potential toxicity to wood mice. The laboratory assessment of exposed wood mice included measurement of brain esterase activities, methiocarb residues in selected mouse tissue, carcasses, and histological evaluation of kidney, liver and lungs.
Dilute caustic high-level radioactive waste slurries can induce pitting corrosion in carbon steel. Cyclic potentiodynamic polarization tests were conducted in simulated and actual waste solutions to determine minimum concentrations of sodium nitrate which inhibit pitting in ASTM A537 class 1 steel exposed to these solutions. Susceptibility to pitting was assessed through microscopic inspection of specimens and inspection of polarization scans. Long-term coupon immersion tests were conducted to verify the nitrite concentrations established by the cyclic potentiodynamic polarization tests. The minimum effective nitrite concentration is expressed as a function of the waste nitrate concentration and temperature.
Passive films were formed on a high purity Fe-23 Cr alloy in acid sulfate solutions in the presence and absence of chloride ion. The resulting film composition was investigated by Auger depth profiling. The passivated samples were exposed to a 1M NaCl solution at a constant potential slightly above the critical pitting potential, and the current-time transient was measured in order to compare the relative stability of the different films. The results obtained suggest that the formation conditions influence the chloride content of the passive film and the breakdown behavior. Passive films formed in the presence of chloride contain and are slightly less stable towards breakdown. No chloride was found in films formed in sulfate and subsequently exposed to chloride well below the pitting potential.
The purpose of this study was to validate through natural exposure a cut-off level of varicella zoster IgG as protective against infection with varicella zoster virus (VZV). Laboratory testing to determine VZV immune status of pregnant women exposed to varicella is recommended. Quantitative assays are now available which are sensitive and specific. More than 200 consecutive requests for screening in pregnant patients with recent varicella contacts were followed-up by questionnaire. DiaSorin LIAISON and VZV time resolved fluorescence immuno assay (VZV TRFIA) were used to measure VZV antibody level. One hundred fifty out of 209 (72%) questionnaires were returned; 14 patients developed varicella, 129 did not and seven were not known. Patients who had been given VZIG and developed varicella on...
Measurements using radioactive targets are important for the determination of key reaction path ways associated with the synthesis of the elements in nuclear astrophysics (sprocess), advanced fuel cycle initiative (transmutation of radioactive waste), and stockpile stewardship. High precision capture cross-section measurements are needed to interpret observations, predict elemental or isotopical ratios, and unobserved abundances. There are two new detector systems that are presently being commissioned at Los Alamos National Laboratory for very precise measurements of (n,{gamma}) and (n,f) cross-sections using small quantities of radioactive samples. DANCE (Detector for Advanced Neutron-Capture Experiments), a 4 {pi} gamma array made up of 160 BaF{sub 2} detectors, is designed to measure neutron capture cross-sections of unstable nuclei in the low-energy range (thermal to {approx}500 keV). The high granularity and high detection efficiency of DANCE, combined with ...
With the aim of preparing carrier-free "2"8Mg and "4"7Ca simultaneously, Ti, V and Fe targets were examined by irradiating with high-energy ions of "1"2C, "1"4N and "1"6O accelerated by the RIKEN ring cyclotron. Among the targets, V gave the highest cross section for the formation of both "2"8Mg and "4"7Ca irrespective of the kind of beams. The cross section for the formation of "2"8Mg by the reactions of Ti, V and Fe targets with ion beams increased in the order of "1"2C<"1"6O<"1"4N. On the other hand, the three beams exhibited almost the same cross sections for the formation of "4"7Ca by the reaction of a given target. Titanium and V were selected as prospective targets and "1"4N as a suitable beam for the production of "2"8Mg and "4"7Ca. Chemical separation procedures of the radiotracers in carrier- and salt-free states have been established by using cation exchange resins. ...
Full text: Measurement of K_#beta# to K_#alpha# x-ray intensity ratios are important not only in the field of atomic physics, radiation physics and medical physics, but also to test the validity of assumptions made in the theoretical prediction. The intensity ratios can also give information on the effect of physical and chemical environment of the element in the compound. Many investigators have adopted a single and double reflection geometries to measure the K_#beta# to K_#alpha# x ray intensity ratios to understand the effect of physical and chemical environment on x-ray fluorescence. The targets are excited by a radioactive source of having activity of the order 100 MBq. in order to carry out accurate measurement K_#beta# to K_#alpha# x-ray intensity ratios, we have develop 2#pi# geometrical configuration method : placing a target right on the surface of the detector facing the target to measure the K shell fluorescence ...
B6C3F1 mice chronically exposed to 3,3′,4,4′-tetrachloroazobenzene (TCAB), a contaminant of dichloroaniline-derived herbicides, developed a number of neoplastic and nonneoplastic...Full Text Available
Theoretical thermodynamical calculations for the ZrO/sub 2/- Al/sub 2/O/sub 3/-SiO/sub 2/ system are given to expose the regions of the most chemically stable products of crystallization. It is established that ceramics on the base of mullite with zircon addition and containing the minimum quantity of glass phase should be preferably used in chemical media containing HCl.
The results of treatment of 53 cases of pediatric localized Ewing's sarcoma and bone reticulosarcoma were analized. Chemoradiotherapy is a procerdure of choice in bone marrow sarcoma treatment: while overall five-year survival was 28.4#+-#6.2%, it was as high as 64.9% in cases of combined treatment (total focal dose of at least 50 Gy+polychemotherapy). Two cases of osteo- and chondrosarcoma development in exposed bone are described.
1. From a 150 mM-NH4 salicylate medium salicylate enters human red cells with a rate constant of 1.9 min-1 at 0 degrees C. 2. Salicylate increases the red cell permeability for Ca2+ (and Mg2+). There...Full Text Available
If 4-day-old dark-grown zucchini squash seedlings (Cucurbita pepo L. cv. Black Beauty) are exposed briefly to red light, subsequent cell fractionation yields about 40% of the total...Full Text Available
By the methods of the angular distribution of photon annihilation, time distribution of photon annihilation, photoluminescence spectroscopy, Fourier IR-spectroscopy, atomic force microscopy the detail information on relation of the structural and physical properties of the porous nano-structures is obtained. Study of pores sizes in a different nano-porous materials, such as the porous silicon, porous anode aluminium oxide, porous solids exposed to light atoms ion implantation (hydrogen, deuterium, helium) is carried out.
Samples of geothermal scale formed from Magmamax No. 1 and Woolsey No. 1 wells in the Imperial Valley, Calif., were exposed to concentrated and dilute solutions of common laboratory reagents. The time of exposure and temperature of the reagent were also varied. Several reagents easily dissolved significant amounts of the scale. An in situ test was performed with marginal success.
In this work, the principal continuum radiative emission processes, which occur during the penetration of ions in solids or gases, are resumed. The characteristics of the following processes are discussed: secondary electron bremsstrahlung (SEB), atomic bremsstrahlung (AB), and internuclear bremsstrahlung (INB). Recent advances of the ion channeling effects in crystal solids on the spontaneous radiative spectra are exposed. (A.C.A.S.).
Exposure of teachers of physics to X-radiation emitted by instruments which are used for demonstrating rarefied gas discharges during physics lessons at secondary schools is discussed. The measurements performed provide an explicit evidence that an effective, annual exposure dose under the most unfavorable conditions does not exceed admissible levels according to Polish regulations pertaining to persons non-occupationally exposed to ionizing radiation. (author). 3 refs,1 fig.
Two methods for measuring indoor radon concentrations using activated charcoal have been tested. The first method is the well-known technique with direct gamma-measurements on the exposed canister after the sampling period. The other method uses a thermoluminescence dosemeter placed in the charcoal canister, giving an integrated value of the radon concentration.
Thirty-two asthmatic volunteers 8 to 16 yr of age, recruited through local schools and private physicians, were exposed in a chamber to clean air (control condition) and to sulfuric acid aerosol at a low concentration (46 +/- 11 micrograms/m3; mean +/- SD) and at a high concentration (127 +/- 21 micrograms/m3). Acid aerosols had mass median aerodynamic diameters near 0.5 microns with geometric standard deviations near 1.9. Temperature was 21 degrees C, and relative humidity was near 50%. Subjects were exposed with unencumbered oronasal breathing for 30 min at rest plus 10 min at moderate exercise (ventilation rate approximately 20 L/min/m2 of body surface). A subgroup (21 subjects) were exposed similarly to clean air and to high acid (134 +/- 20 micrograms/m3) with 100% oral breathing. Increased symptoms and bronchoconstriction were found after exercise under all exposure conditions. For the group, symptom and lung function ...
Reflective diffraction grating. A focused ion beam (FIB) micromilling apparatus is used to store color images in a durable medium by milling away portions of the surface of the medium to produce a reflective diffraction grating with blazed pits. The images are retrieved by exposing the surface of the grating to polychromatic light from a particular incident bearing and observing the light reflected by the surface from specified reception bearing.
Food irradiation is the process of exposing food to an ionizing energy to kill harmful bacteria and other organisms and extend shelf-life. It is a safe process and has been approved by some 50 countries worldwide and applied commercially in the USA, Japan, China and several European countries for many years. Trends law regulations and new applications in Europe and another countries has been described. (author)
This Test Plan outlines the testing to be done on the Special Protective Coating (SPC) Polyurea which includes: Tank Waste Compatibility, Decontamination Factor Testing, and Adhesion Strength Testing after a sample has been exposed to Radiation.
Accumulation of "8"5Kr in arterial blood of sheep occurs within 10 min of inhalation exposure initiation, and disappears by 30 min after exposure termination. As reported for other species, "8"5Kr concentrations in fat were approximately 10 times those in other tissues.
To suppress space charge blowup in an ion beam passing through a photoneutralizer, it is necessary to introduce some background gas. An analysis is presented of the neutralization of a high-energy, >200-keV negative deuterium ion beam, exposed to photodetachment while in the presence of deuterium. With a gas thickness of <0.01 Torr.cm, the neutral fraction in the output beam is found to be about the same as that gotten from the photoneutralizer operating in vacuum. Neutral atom beam injection for plasma heating is discussed.
Heavy high viscosity oils, transformer oils, and very light low viscosity oils have been used in a Norwegian company in the impregnation, sheathing, and installation of paper insulated cables. The aim...Full Text Available
Medico-biological aspects of Chernobyl accident among suffered children and adult population in Ukraine are exposed. Health condition of children irradiated in postnatal period and born from irradiated parents are described. Results of the most important organs and systems monitoring in different categories of suffered adults and data about non-stochastic and stochastic effects are given. Special attention is given to neuropsychiatric and endocrinological effects, conditions of visceral systems
A joint materials test program developed by the Institute for Mining and Minerals Research (IMMR) and the Tennessee Valley Authority (TVA) involved the postexposure mechanical properties and corrosion behavior of candidate structural materials in an experimental, atmospheric fluidized-bed combustor (AFBC). This combustor was operated by Accurex Corporation at Research Triangle Park, North Carolina, under the direction of TVA. The materials studied were Type 304, Type 310, and INCOLOY alloy 800 in the form of disc coupons with and without crevice configurations. Type 304 was also used for mechanical property measurements. The alloys were exposed to the combustor environment at about840/sup 0/C for approximately 330 hours. The ranking in terms of decreasing weight loss was: (1) Type 304, (2) Type 310, and (3) INCOLOY alloy 800. The presence of tight crevices did not enhance the corrosion rate. In addition, the corrosion rates, based on the weight loss (typically 1 to ...
The industrial solvent trichloroethylene (TCE) and its major metabolites have been shown to cause formic aciduria in male rats. We have examined whether chloral hydrate (CH) and trichloroacetic...Full Text Available
We report on the fouling of Focused Ion Beam (FIB)-fabricated silicon oxide nanopores after exposure to tap water for two weeks. Pore clogging was monitored by Scanning Electron Microscopy (SEM) on both bare silicon oxide and chemically functionalized nanopores. While fouling occurred on hydrophilic silicon oxide pore walls, the hydrophobic nature of alkane chains prevented clogging on the chemically functionalized pore walls. These results have implications for nanopore sensing platform design.
Pregnant rats were exposed to "8"5Kr for 4-6 hr and sacrificed immediately thereafter. The "8"5Kr concentration in the fetoplacental unit (FPU) was approximately the same at all gestation stages for intact FPU, isolated fetuses or fetal segments, as well as placentas and associated membranes. Maternal tissue concentrations varied over a wide range and only liver and intestine concentrations were relatively similar in both 20-day-gestation (dg) fetuses and adults.
In 1998, research began at Idaho National Engineering and Environmental Laboratory to investigate the application of {sup 6}Li and {sup 7}Li isotopes to the measurement of neutron and gamma radiation. Various size pairs of {sup 6}Li and {sup 7}Li based detectors were exposed to mixed neutron and gamma radiation. Experiments demonstrated that these detectors could be used to measure low level neutron radiation in the presence of high level gamma radiation. (author)
In 1998, research began at Idaho National Engineering and Environmental Laboratory to investigate the application of "6Li and "7Li isotopes to the measurement of neutron and gamma radiation. Various size pairs of "6Li and "7Li based detectors were exposed to mixed neutron and gamma radiation. Experiments demonstrated that these detectors could be used to measure low level neutron radiation in the presence of high level gamma radiation. (author)
32P-Postlabeling analysis and enzyme-linked immunosorbent assay (ELISA) have been used to detect DNA adducts in peripheral blood lymphocytes from primary aluminum production plant workers who were exposed...Full Text Available
Simulated atmospheric corrosion studies were performed to determine the corrosion protection provided by galvanized zinc coatings on depleted uranium, U-0.75 Ti alloy, and U-6 Nb alloys. The accelerated ASTM tests consisted of exposing the galvanized samples to aqueous and aqueous chloride environments. The test results showed that anodic protection was provided by the electronegative zinc coatings on uranium and uranium alloys. Treating zinc with chromate conversion coatings also provided more protection.
To reduce the number of regular break-ins on CERN machines due to passwords exposed on the network in clear text, OFF-SITE FTP ACCESS TO CERN WILL BE BLOCKED in the CERN firewall from: Tuesday 20th January 2004 If you use ftp to access CERN computers from outside CERN then please see the link below for alternative access means and further advice: http://cern.ch/security/ftp Denise Heagerty, CERN Computer Security officer, Computer.Security@cern.ch
To reduce the number of regular break-ins on CERN machines due to passwords exposed on the network in clear text, OFF-SITE FTP ACCESS TO CERN WILL BE BLOCKED in the CERN firewall from: Tuesday 20th January 2004 If you use ftp to access CERN computers from outside CERN then please see the link below for alternative access means and further advice: http://cern.ch/security/ftp Denise Heagerty, CERN Computer Security officer, Computer.Security@cern.ch
The eastern oyster (Crassostrea virginica) developed neoplastic disorders when experimentally exposed both in the laboratory and field to chemically contaminated sediment from Black Rock Harbor (BRH),...Full Text Available
A side terminal battery is described comprising: a casing having a side wall made from a moldable material; and a plug formed of relatively deformable, electrically conductive, corrosion resistant material molded into the side wall to form a seal between the interior and exterior of the casing and including a battery terminal insert embedded therein so as to be exposed at the exterior of the casing and isolated, by the plug, from the interior of the casing.
The influence of carbon monoxide (CO) exposure on regional cerebral blood flow (r-CBF) in rat brain was studied using autoradiography and "1"2"5I-IMP. Fuji computed radiography (FCR) was used to obtain improved autoradiograms in this study. R-CBF was determined in a relative measure by calculating hippocampus/cortex and putamen/cortex ratios of RI accumulation from the autoradiogram using a densitometer. Comparison of autoradiograms with pathological findings in the area of the hippocampus and putamen yield the following results. In the animals that were exposed to 6400 ppm or 10000 ppm of CO for 30 minutes, and then were followed up for 2 weeks without further exposure, r-CBF was decreased but no pathological changes occurred. In the animals that were exposed to 6400 ppm or 10000 ppm of CO, and then were followed up for 4 weeks without further exposure, pathological changes appeared. In animals exposed to 3200 ppm of CO, ...
The influence of carbon monoxide (CO) exposure on regional cerebral blood flow (r-CBF) in rat brain was studied using autoradiography and {sup 125}I-IMP. Fuji computed radiography (FCR) was used to obtain improved autoradiograms in this study. R-CBF was determined in a relative measure by calculating hippocampus/cortex and putamen/cortex ratios of RI accumulation from the autoradiogram using a densitometer. Comparison of autoradiograms with pathological findings in the area of the hippocampus and putamen yield the following results. In the animals that were exposed to 6400 ppm or 10000 ppm of CO for 30 minutes, and then were followed up for 2 weeks without further exposure, r-CBF was decreased but no pathological changes occurred. In the animals that were exposed to 6400 ppm or 10000 ppm of CO, and then were followed up for 4 weeks without further exposure, pathological changes appeared. In animals exposed to 3200 ppm of ...
We demonstrate the use of a variational method to determine a quantitative lower bound on the rate of convergence of Markov Chain Monte Carlo (MCMC) algorithms as a function of the target density and proposal density. The bound relies on approximating the second largest eigenvalue in the spectrum of the MCMC operator using a variational principle and the approach is applicable to problems with continuous state spaces. We apply the method to one dimensional examples with Gaussian and quartic target densities, and we contrast the performance of the basic Metropolis-Hastings algorithms with a ``smart'' variant that incorporates gradient information into the trial moves. We find that the variational method agrees quite closely with numerical simulations. We also see that the smart MCMC algorithm often fails to converge geometrically in the tails of the target density except in the simplest case we examine, and even then care ...
Transmission nuclear resonance fluorescence measurements were made on targets consisting of Pb and depleted U with total areal densities near 86g/cm"2. The "2"3"8U content in the targets varied from 0% to 8.5% (atom fraction). The experiment demonstrates the capability of using transmission measurements as a non-destructive technique to identify and quantify the presence of an isotope in samples with thicknesses comparable to the average thickness of a nuclear fuel assembly. The experimental data also appear to demonstrate the process of notch refilling with a predictable intensity. Comparison of measured spectra to previous backscatter "2"3"8U measurements indicates general agreement in observed excited states. Evidence of two new "2"3"8U excited states and possibly a third state have also been observed.
The introduction of oxygen in the vicinity of a metallic target surface, bombarded with positive argon ions of twenty kiloelectron-volts, increases the number of sputtered atoms in the excited state. This phenomenon of exaltation, very sensitive in the case of nickel and aluminium, is much less marked in the case of molybdenum. Moreover, the emission of excited particles coming from the beam's ions is not modified. A quantum-mechanical model of a kinetic emission process, which permits the interpretation of the clean metallic target's emission phenomena, seems insufficient to explain all of the results obtained in the presence of oxygen. In this last case one can therfore use a thermodynamic model in which excited metallic particles can be formed directly by chemical surface reactions of neutralization or reduction. (orig.).
A promising drug target currently under investigation to improve cognitive deficits in neuropsychiatric and neurological disorders is the neuronal nicotinic alpha7 acetylcholine receptor (a7nAChR). Improving cognitive impairments in diseases such as Alzheimer's (AD) and schizophrenia remains a large unmet medical need, and the a7nAChR has many properties that make it an attractive therapeutic target. The a7nAChR is a ligand gated ion channel that has particularly high permeability to Ca^2^+ and is expressed in key brain regions involved in cognitive processes (e.g., hippocampus). The a7nAChRs are localized both pre-synaptically, where they can regulate neurotransmitter release, and post-synaptically where they can activate intracellular signaling cascades and influence downstream processes...
The main goal of local drug delivery is to increase the concentration of a specific therapeutic agent in a target tissue with minimal nontarget distribution. Compared to systemic therapy, local drug delivery provides a high level of therapeutic efficacy with minimal systemic effects. The current primary imaging modality for drug delivery has been x-ray angiography, but it has major limitations including anatomical ambiguity and inability to visualize the targeted tissues. Due to these inherent problems, MR guidance has been explored as an alternative imaging modality for guiding and monitoring of drug therapy. Recently, interventional MR (XMR) systems have been implemented that have both dual x-ray and MRI capabilities in a single suite and allow for real-time interventional procedures to ...
A new procedure of fuel layering for the Fast Ignition Realization Experiment (FIREX) target is proposed. A conical laser guide heating technique was experimentally demonstrated in principle as the followings. It employed the target consisting of a polystyrene (PS) shell, a fill tube and a conical laser guide. At first, liquid fuel was fed into the shell and existed around the conical laser guide because the surface tension of the fuel must cause it. Then, it was solidified. The laser light provided a heat source to the conical laser guide so that the solid fuel was moved to the other interior of the shell. This process resulted in missing solid fuel around the conical laser guide. To fill the vacant space, liquid fuel was added as temperature was raised to the melting point. After the liquid fuel addition, temperature was lowered to the solidification point again. During this process, most of the solid fuel could survive.
Targets for heterogeneous transmutation of americium are composed of a support material, the inert matrix and of an americium oxide compound: AmO{sub 2-x} or Am{sub 2}O{sub 3}. In parallel to the studies using americium, simulated compounds of americium oxide, chosen amongst lanthanide oxides, are used. The selection of these compounds is based on theoretical, physical and crystallochemical considerations. In order to assess the influence of impurities composed of lanthanide oxides, resulting from the separation process, on the physical and chemical properties of such a target, synthesis of oxide powders containing impurities associated with the simulated americium oxide, characterizations, crystallographic studies and sodium compatibility tests have been performed. (author)
We have studied L x-rays from 64 MeV iodine projectile in collision with various gas targets, Z_2 #18, do not arise from selective M subshell vacancy population, has been conclusively established by the observations by Datz et al (1971) and by Saha et al (1996) that the measured intensity ratio of the Ll and L#alpha# lines, which arise because of transitions from different M subshells into the same L, subshell, does not show any periodic behaviour with Z, but stays rather constant. Differences in the measured L#beta#_1/L#alpha# intensity ratio of iodine with 7"+ and 24"+ charge states impinging on Kr target established the minor role of the electrons in the N shell of the projectile in the x-ray production mechanism. (author)
Pulsed atomic beams produced in vacuum by laser induced ablation from a lithium target are analyzed by laser induced fluorescence (LIF). The 1-mixing processes induced in the n = 9, 10 Li Rydberg states by collisions with CO_2 molecules illustrate the application of the method. Resolution is limited by the 1 mm diameter of the probe laser beam. Combining LIF and absorption measurements gives n_L_i as a function of time at various distances from the target surface. The investigation of the Li-C0_2 1-mixing process in a heat pipe oven proved impossible due to the high reactivity of Li with C0_2. This problem was solved by renewing the Li atoms at each laser shot. Values obtained for n = 9, n = 10 are k = 17 x 10"-"8 and 15 x 10"-"8 cc/sec, respectively.
Heavy ion irradiation on tantalum metal target with 57 MeV {sup 11}B{sup 4+} leads to the production of no-carrier-added radioisotopes of platinum, {sup 187,188}Pt and iridium, {sup 187,188}Ir in the matrix, which have been effectively separated from the bulk target and from each other with suitable anion exchangers employing liquid-liquid extraction (LLX). Also {sup 188,189}Pt and {sup 188,189}Ir radionuclides have been produced, from their short-lived precursors {sup 188,189}Au, in {sup 12}C{sup 6+} irradiated tantalum matrix. Gamma-spectroscopy has been utilised to determine the production, extent of separation and purity of the radiotracers at different stages of the experiment. (orig.)
TiH{sub 2} and TiD{sub 2} thick targets were bombarded with 100 to 200 keV protons. Evidence for nuclear reactions was obtained by means of a surface barrier particle detector. Proton irradiation of TiD{sub 2} produced the following observations: {alpha} particle emission identified as (p, {alpha}) reactions from {sup 11}B and {sup 7}Li impurities in the target at ppm concentrations; and {approx}3 MeV proton and {approx}1 MeV triton emission from secondary D-D reactions caused by elastic scattering of the primary proton with a target deuteron. A 3.9 MeV {alpha} particle peak measured by others was not observed. (author)
Linearly polarized laser radiation accelerates electrons to very high velocities and these electron form a sheath layer on the rear side of thin targets where preferentially protons are accelerated. When mass-limited targets are used, the lateral transport of the absorbed laser energy is reduced and the accelerating field is enhanced. For targets consisting of two ion species, heavier ions facilitate formation of quasi-monoenergetic bunch of lighter ions. For circularly polarized light, fast electron production is suppressed by the absence of the oscillatory component of the ponderomotive force. Ions are accelerated on the front side by the separation field and very thin foil can be accelerated as one massive quasi-neutral block. As all ion species acquire the same velocity, this acceleration mechanism is preferred for heavier ions.
The present work summarizes efforts on the simulation of natural convection cooling within the IFMIF target and test cell. The simulations have been performed with the STAR-CD code using the k-#omega# high-Reynolds number turbulence model. A dedicated thermohydraulic model has been devised including Lithium loop components. Nuclear heat production has been calculated by the Monte-Carlo code McDeLicious for different parts of the target and test cell walls and was used as input for the STAR-CD simulations. Helium atmospheres at several pressures from 0.1 to 10"-"5 MPa have been investigated. In order to limit the maximum temperature of the concrete walls to 80 deg. C it was necessary to add thermal insulation layers to the hot Lithium loop surfaces and a conceptual system of two cooling layers in different depths of the concrete walls.
The penumbra of the profile function describing the nuclear collisions of relativistic heavy ions is related to the cross section for their producing a specific target-nucleus #gamma#-ray, sigmasub(#gamma#). The analysis assumes that the diffuse-edge diffraction model suffices to calculate the inelastic cross sections to the particle-stable states of the target nucleus. When the deformation lengths, deltasub(L) = #beta#sub(L)R, characterizing all important excitations are available from other experiments and the #gamma#-branching of these states is also known, the only unknown quantity determining sigmasub(#gamma#) is found to be the ratio of the diffuseness parameter of the profile function, d, to its radius, R. The most reliably determined values of d/R, for the target "4"0Ca, imply a rather wide penumbra, consistent with microscopic calculations. (orig.).
This paper presents a study involving prediction of a complicated maneuvering target, with the aim of improving the tracking performance of a fire control system (FCS). In this study, we predict the position of a complicated maneuvering target 5 s in advance using the information up to the current time. Because of the large error caused by the complicated maneuvers and the long prediction time interval, the mechanical system of the fire control system will take a heavy load. In order to cope with this problem, several approaches to decreasing the prediction error have been proposed including the prediction algorithms based on the multiple model(MM) filter, interacting multiple model (IMM) filter, and variable dimension with input estimation (VDIE) filter. Finally, comparative simulation re...
The launch of the first spaceborne hyperspectral instrument, Hyperion, in 2000 has provoked further research into its capabilities with regard to mineral exploration. Our study in the remote, mountainous region of Pulang, China employed a two-step progressive approach, first to locate target areas characterized by hydrothermal mineral alteration, using the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), and secondly, to attempt detailed mineral mapping using Hyperion. The preliminary target detection involved principal components and broad-band spectral analysis and led to the detection of two target areas characterized by argillic alteration, iron-oxide- and sulphate-bearing minerals. A focused hyperspectral study followed using Spectral Angle Mapper (SAM) and Mixt...
In simulations with high radiated power fractions, it is possible to produce the drop in ion current to the divertor targets typical of detached plasmas. Despite the fact that these experiments are performed on beryllium target tiles, radiation from deuterium and beryllium cannot account for the measured power losses. The neutral deuterium levels in the SOL in these plasmas are higher than the model predicts. This may be due to leakage from the divertor or to additional wall sources related to the non-steady nature of these plasmas. In contrast, a surprisingly high level of carbon is present in these discharges; higher even than would be predicted are the divertor target tiles pure carbon. This level may well be large enough to produce the measured radiation. (authors). 6 refs., 2 figs., 1 tab.
Comparisons of calculated neutron yield distributions from #alpha#-particle induced reactions on thick targets are made with measured data to analyze the initial reaction process in the framework of the exciton (hybrid) model code ALICE91 (M. Blann, Lawrence Livermore National Laboratory Report UCID 19614, 1982). We have considered two reaction mechanisms: dissolution of the #alpha# in the nuclear field, and preequilibrium processes initiated by #alpha#-nucleon collisions. Both these processes seem to contribute to the emitted neutron spectra in varying proportions depending on the incident #alpha# energy and possibly on the target nucleus. Contributions from other processes appear to be non-negligible.
A combined numerical and theoretical study is conducted herein on the penetration of semi-infinite targets by jacketed rods with different r"j"0/r"c"0 ratios where r"j"0 and r"c"0 are the radii of the jacket and the core, respectively. The numerical results show that for smaller r"j"0/r"c"0 ratios the u-v relationship changes only a little compared to that of unitary long rod penetrator of the same core material, hence, the u-v relationship of unitary (homogeneous) long rod penetration is also applicable for jacketed rod penetration. Model for cratering in semi-infinite targets by jacketed rods is then suggested by using the laws of conversation of mass, momentum and energy, together with the u-v relationship of unitary (homogeneous) long rod penetration and an analytical model for predict...
When the use of retarders in utility vehicles increased in the middle of the 80s, the Forschungsvereinigung Automobiltechnik (FAT) commissioned a study on the safety aspect of this braking technology in trucks. Retarders are wear-free permanent brakes that are fitted in the drive transmission system of utility vehicles, thereby generating braking forces only at the wheels of the live shaft. The question of the possible overbraking of the live shafts was just as well investigated as the interaction between the retarder and service brake in so-called integrated braking systems, and both under conditions of low adhesion as well as in the border area of the dynamics of vehicle movement. This subject met with considerable joint interest on the part of the motor vehicle industry as well as of manufacturers of towed vehicles and unit sets. FAT, therefore, commissioned the Institut fuer Kraftfahrwesen of the University of Hannover to carry out a three-phase research ...
The first commercial vehicle, built by Gottlieb Daimler in Cannstatt (Germany), head foto, had been the begin of a new transport technology around the world. Benz had been consolidated 1926 with Daimler to the Daimler-Benz AG with a new vehicle programme; all trucks over 5 t payload would be powered since 1935 by diesel engines only. Worldwide all-wheel drived vehicles had been under development for different purposes. After 1945 the European Automobil industry launched at first former types followed by new designed and improved types. The eight-wheeler used since the twentees in England conquered Switzerland, and in 1984 Germany too. The development of gear boxes and drive axles had been influenced on the drive train demands depending of the engine output and speed and the increased GTW. The future of the commercial vehicles will be determined by the European legislation, higher economy and reduced-pollutant Euro II and later Euro III engines, further by the ...
AbstractThe optimal definition of the size, shape and location of gross tumour volume is one of the most important steps in the planning of radiation therapy, and necessitates a proper...Full Text Available
Effector proteins expressed in the esophageal gland cells of cyst nematodes are delivered into plant cells through a hollow, protrusible stylet. Although evidence indicates that effector proteins function...Full Text Available
The substantia nigra pars reticulata (SNR) represents an endogenous seizure suppressing system, which may be targeted to develop treatments for generalized or multifocal epilepsies. This review summarizes...Full Text Available
Three-dimensional dynamics of a compact toroid (CT) plasmoid, which is injected into a magnetized target plasma region is investigated by using magnetohydrodynamic (MHD) numerical simulations. It is found that the process of the CT penetration into this region is much more complicated than what has been analyzed so far by using a conducting sphere (CS) model. The injected CT suffers from a tilting instability, which grows with the similar time scale as the CT penetration. The instability is accompanied by magnetic reconnection between the CT magnetic field and the target magnetic field, which disrupts the magnetic configuration of the CT. Magnetic reconnection plays a role to supply the high density plasma initially confined in the CT magnetic field into the target region. Also, the penetration depth of the CT high density plasma is examined. It is shown to be shorter than that estimated from the CS model. The CT high ...
Lists of reportable conditions and case definitions are important tools for epidemiologic surveillance. As part of an initiative to encourage occupational disease surveillance systems linked to intervention...Full Text Available
None of the materials presently in common use for polarized proton targets has a pure carbon nuclear background. The alcohols and diols contain some oxygen, and the ammonia and amine-based materials contain nitrogen and/or other noncarbon species. In the latter cases the noncarbon nuclei are measurably polarized as a concomitant of the process used to polarize the hydrogen nuclei. The relative simplicity of a pure carbon background would be advantageous for most types of scattering experiments and perhaps crucial for some. In addition to simplifying the kinematics of background events, pure carbon is relatively easy to prepare as a dummy'' target for background subtraction. Also, in such a target material, [sup 13]C-enrichment would yield a clean polarized [sup 13]C material. In this note I explore the possibilities for such materials, touching upon only what I consider to be the ...
The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover,...Full Text Available
p53 plays a critical role in tumor suppression. As a transcription factor, in response to stress signals, p53 regulates its target genes and initiates stress responses, including cell cycle arrest,...Full Text Available
EOS Technologies has been commissioned to design and build a unique 2.4m astronomical telescope for the Magdalena Ridge Observatory. This telescope utilizes a high quality primary mirror and cell from a now decommissioned military application. This paper describes the project and gives an overview of the telescope design. The Magdalena Ridge Observatory (MRO) 2.4 meter telescope will be primarily utilized to observe, track, and characterize solar system astronomical targets, Earth satellites, space vehicles, and terrestrial military targets. The telescope's rapid tracking (slew rates are 10o/sec) will allow it to move to any target and acquire data within one minute of receipt of notice. In this way, the telescope will be used to capitalize on targets of opportunity that occur in asteroid studies (e.g., Near Earth Objects) and in astrophysics, such as gamma ray bursts and other transient phenomena. ...
BackgroundCharacterizing infectious disease burden in Africa is important for prioritizing and targeting limited resources for curative and preventive services and monitoring the...Full Text Available
The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent antitumour surveillance mechanisms of p53 through mutation of the TP53...Full Text Available
Syndrome X is a combination or co-occurrence of several known cardiovascular risk factors (including central obesity, dyslipidemias, fatty liver disease, hyperinsulinemia, insulin resistance,...Full Text Available
The development of new methods for gene addition to mammalian genomes is necessary to overcome the limitations of conventional genetic engineering strategies. Although a variety of DNA-modifying enzymes...Full Text Available
We investigate a method for gene delivery to vascular smooth muscle cells using ultrasound triggered delivery of plasmid DNA from electrostatically coupled cationic microbubbles. Microbubbles...Full Text Available
Immunotoxicity encompasses both reduced and heightened immune function. Diverse chemicals can impair functioning of the immune system. Both monographs and books have been devoted to detailed descriptions...Full Text Available
Systematics of neutron capture radiative width were studied in the target element range from Th to Cm. Reduced radiative widths were analyzed with a simple radiative width formula based on E1 transition. Average radiative width is presented with the standard deviation of 15%. (author)
Atg4 cysteine proteases (autophagins) play crucial roles in autophagy by proteolytic activation of Atg8 paralogs for targeting to autophagic vesicles by lipid conjugation, as well as in subsequent deconjugation...Full Text Available
We have synthesized a novel stable precursor, saligenin phosphorotrichloridate, which, on reaction with N-monobiotinyldiamines, generates a series of biotinylated covalent inhibitors of serine esterases....Full Text Available
SUMMARYThe cytolytic activity of natural killer (NK) cells is regulated by inhibitory receptors that detect the absence of self molecules on target cells. Structural studies of...Full Text Available
Purpose: This paper reviews and reassesses the internationally accepted niches or ‘targets’ in bone marrow that are sensitive to the induction of leukaemia and primary...Full Text Available
MicroRNAs (miRNAs) are short non-coding RNAs that play a central role in regulation of gene expression by binding to target genes. Many miRNAs were associated with the function of the central nervous...Full Text Available
PrefaceCardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation, vascular smooth muscle cell anti-migratory actions, and anti-inflammatory actions. These...Full Text Available
SummarySoluble epoxide hydrolase (sEH) is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs). Genetic variations...Full Text Available
The intracellular bioavailability of lead (Pb) at low dosage levels in major target organs such as the kidney and brain appears to be largely determined by complexation with a group of low molecular...Full Text Available
A vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially, superoxide and hydroxyl radical) and high-energy oxidants [such as peroxynitrite (OONO−)]...Full Text Available
The polymerase chain reaction (PCR) was investigated as a means of diagnosing Mycoplasma pneumoniae infections. The target DNA sequence was a 375-bp segment of the P1 virulence protein. This DNA segment...Full Text Available
Target of rapamycin (TOR) kinases control cell growth through two functionally distinct multiprotein complexes. TOR complex 1 (TORC1) controls temporal cell growth and is sensitive to rapamycin, whereas...Full Text Available
The Gordon Research Conference (GRC) on ROCK DEFORMATION was held at II Ciocco from 5/19/02 thru 5/24/02. Emphasis was placed on current unpublished research and discussion of the future target areas in this field.
Some of most used indicators in marine ecology are nucleic acid-derived indices. They can be divided by target levels in three groups: 1) at the organism level as ecophysiologic indicators, indicators...Full Text Available
Breast cancer is a progressive and potentially fatal disease that affects women of all ages. Like all progressive diseases, early and reliable diagnosis is the key for successful treatment and annihilation....Full Text Available
Thiobenzamide (TB) is a potent hepatotoxin in rats, causing dose-dependent hyperbilirubinemia, steatosis, and centrolobular necrosis. These effects arise subsequent to and appear to result from...Full Text Available
It has been sixty years since the Millers first described the covalent binding of carcinogens to tissue proteins. Protein covalent binding was gradually overshadowed by the emergence of DNA...Full Text Available
The parathyroid hormone receptor (PTHR) is a class B G protein-coupled receptor that plays critical roles in bone and mineral ion metabolism. Ligand binding to the PTHR involves interactions to both...Full Text Available
The "6"2Zn-"6"2Cu generator system is one of the few which yield a pure positron emitting daughter. The authors have developed a method for the preparation of this generator system following 32 MeV #alpha# particle bombardment of nickel targets. The chemical processing involves two stages: first a hydrous zirconium oxide column is used at pH 4-5 to separate the zinc and copper activities produced in the target nickel, and secondly, a conventional anion exchange column is used to retain the "6"2Zn and remove all copper activities in 2M HCl. This column serves as the "6"2Cu generator which will yield pure "6"2Cu repeatedly, free from "6"2Zn and other impurities, in a mixture of HCl and NaCl. A method is outlined also to obtain a solution of "6"2Zn using the hydrous zirconium oxide (HZO) column. "6"1Cu can be prepared as a by-product in the above procedure, but a method for the preparation of "6"1Cu alone using an 18 MeV #alpha# particle beam on a ...
Epidermal growth factor receptor (EGFR) related therapies – mainly tyrosine kinase inhibitors (TKIs) such as erlotinib and gefitinib, but also monoclonal antibodies targeting EGFR, for example,...Full Text Available
Rapamycin inhibits the mTOR (target of rapamycin) pathway and extends lifespan in multiple species. The tuberous sclerosis complex (TSC) protein is a negative regulator of mTOR. In humans, loss of the...Full Text Available
Previous studies in several different trigeminal nerve injury/inflammation models indicated that the hyperexcitability of primary afferent neurons contributes to the pain pathway underlying mechanical...Full Text Available
Patients with pancreatic cancer normally present with advanced disease that is lethal and notoriously difficult to treat. Survival has not improved dramatically, despite routine use of chemotherapy...Full Text Available
BackgroundThe genus Vibrio is a diverse group of Gram-negative bacteria comprised of 74 species. Furthermore, the genus has and is expected to continue expanding...Full Text Available
In order to optimize the production of "2"0"1Tl and "6"7Ga using the (p, xn) reactions on enriched "2"0"3Tl and "6"8Zn targets we established a new set of cross section curves for the most relevant reactions. Target stacks made of up to 15 thin (50 #mu#m) natural Tl or Zn foils interleaved with brass degradation foils were irradiated with incident proton energies from 42 to 10 MeV in overlapping experiments. Yields for "2"0"0","2"0"1","2"0"2"m","2"0"3","2"0"4"mPB and "6"6","6"7","6"8Ga were computed from measured #gamma# emission rates. Where possible, cross section curves for the nuclear reactions involved were computed. Thick target yields and contamination ratios for enriched targets were derived and show good agreement with results from actual production runs. (orig.).
Hypothyroidism and thyrotoxicosis are each associated with an increased risk of fracture. Although thyroxine (T4) is the predominant circulating thyroid hormone, target cell responses are determined...Full Text Available
BackgroundStem cell characteristics are an important feature of human cancer cells and play a major role in the therapy resistance of tumours. Strategies to target cancer stem cells...Full Text Available
Nicotine is the main psychoactive ingredient in tobacco and its rewarding effects are considered primarily responsible for persistent tobacco smoking and relapse. Although dopamine has been extensively...Full Text Available
Treating brain tumors using inhibitors of angiogenesis is extensively researched and tested in clinical trials. Although anti-angiogenic treatment holds a great potential for treating primary and secondary...Full Text Available
The 37/67-kd laminin receptor, LAMR, is a multifunctional protein that associates with the 40S ribosomal subunit and also localizes to the cell membrane to interact with the extracellular matrix. LAMR...Full Text Available
BackgroundIntrafractional motion results in local over- and under-dosage in particle therapy with a scanned beam. Scanned beam delivery offers the possibility to compensate target...Full Text Available
The sequence-dependent structural variability and conformational dynamics of DNA play pivotal roles in many biological milieus, such as in the site-specific binding of transcription factors to target...Full Text Available
MicroRNAs (miRNAs) are endogenously encoded small noncoding RNAs, derived by processing of short RNA hairpins, that can inhibit the translation of mRNAs bearing partially complementary target sequences....Full Text Available
BackgroundCD26 (dipeptidyl peptidase IV, DPPIV) is a 110 kDa surface glycoprotein expressed in most normal tissues, and is a potential novel therapeutic target for selected cancers....Full Text Available
64Cu (T1/2=12.7h, ?- decay: 40%, ?+ decay: 19%, E.C. decay: 41%) is one of the most useful radioisotope in the nuclear medicine due to its multiple decay mode and the intermediate half-life. Several nuclear reaction, i.e., 64Ni(p,n)64Cu, 68Zn(p,?n)64Cu and 64Ni(d,2n)64Cu have been investigated for production. The highest could be obtained with proton irradiation on the enriched 64Ni target. For mass and routine production, the 64Ni target fabrication using electroplating, the reliable chemical separation of 64Cu from the irradiated 64Ni target and the effective recovery process for the recycling of very expensive enriched material ($20,000/g) and so forth are absolutely necessary to be established. In this work, we report our mass production method of 64Cu with 64Ni and Cyclone-30 accelerator
Inducible gene expression appears to be an essential event that couples light to entrainment of the master mammalian circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus....Full Text Available
BackgroundGene expression profiling and the analysis of protein-protein interaction (PPI) networks may support the identification of disease bio-markers and potential drug targets....Full Text Available
Epithelial-mesenchymal transition (EMT), a switch of polarized epithelial cells to a migratory, fibroblastoid phenotype, is considered a key process driving tumor cell invasiveness and metastasis....Full Text Available
We have characterized the kinetic response of gene targets throughout the murine genome to transcriptional modulation by the glucocorticoid receptor (GR). In contrast to a model in which multiple genes...Full Text Available
Gastrin-releasing peptide receptor (GRPR), a member of the G protein-coupled receptor superfamily, has been utilized for receptor-mediated targeting of imaging and therapeutic agents; here we extend...Full Text Available
To define the import pathway for apoiso-1-cytochrome c in vivo, the coding region for bacterial chloramphenicol acetyltransferase (CAT) or yeast copper metallothionein (CuMT) was fused to the carboxy...Full Text Available
A detailed molecular characterization of nuclear mRNA export will require an in vitro system, allowing a biochemical reconstitution of transport. To this end, an mRNA export assay has...Full Text Available
An immunoglobulin Mk monoclonal (F8IVE9) antibody raised against oat (Avena sativa cv Garry) root homogenate has been produced and characterized. The predominant target...Full Text Available
Neuropilin-1 (NRP1) acts as a co-receptor for class 3 semaphorins and vascular endothelial growth factor and is an attractive angiogenesis target for cancer therapy. In addition to the transmembrane...Full Text Available
BackgroundASCL1 role in pancreatic endocrine tumourigenesis has not been established. Recently it was suggested that ASCL1 negatively controls expression of the...Full Text Available
BackgroundIn chordates, retinoid metabolism is an important target of short-chain dehydrogenases/reductases (SDRs). It is not known whether SDRs play a role in retinoid...Full Text Available
... 154. By way of comparison, the aquatic weed Hygrophila polysperma (Roxb.) T. Anderson, a potential target for biological ... L. Sutton. 2000. Is the aquatic weed hygrophila, Hygrophila polysperma (Polemon...
SUMMARYDendritic cells (DCs) in mucosal surfaces are early targets for human immunodeficiency virus-1 (HIV-1). DCs mount rapid and robust immune responses upon pathogen encounter....Full Text Available
BackgroundPolyadenylation of RNA has a decisive influence on RNA stability. Depending on the organisms or subcellular compartment, it either enhances transcript stability or targets...Full Text Available
Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity...Full Text Available
BackgroundCalcium homeostasis is a known target of several environmental toxicants including lead and mercury.ObjectiveOur goal was to determine...Full Text Available
Jan 20, 1995 ... Jenn-Air dowedraft cooktop, staintess steel, coil. $75; telephone ans mach, $25. Eric, x31917. $295; President & First Lady premier plus ...
Recently, we demonstrated that the central ghrelin signalling system, involving the ghrelin receptor (GHS-R1A), is important for alcohol reinforcement. Ghrelin targets a key mesolimbic circuit involved...Full Text Available
SummaryBlastomycosis is a serious and potentially fatal infection by the thermally dimorphic fungus Blastomyces dermatitidis. PCR assays targeting the BAD-1 virulence...Full Text Available
Optimal sample handling techniques for tissue preparation and storage, RNA extraction and quantification, and target gene detection are crucial for reliable gene expression analysis. Methods...Full Text Available
The cancer preventive action of (−)-epigallocatechin gallate (EGCG), found in green tea, is strongly supported by epidemiology and laboratory research data. However, the mechanism by...Full Text Available
Amphibian population declines and sudden species' extinctions began to be noted at the beginning of the 1980s. Understanding the causes of the losses is hampered by our poor knowledge of the amphibian...Full Text Available
In recent years, the food and beverage industry in the US has viewed children and adolescents as a major market force. As a result, children and adolescents are now the target of intense and specialized...Full Text Available
The heterogeneity of metastatic breast cancer mandates the need to select therapies taking into account tumor and patient characteristics. Chemotherapy is indicated in the palliative setting especially...Full Text Available
Phonological density refers to the number of words that can be generated by replacing a phoneme in a target word with another phoneme in the same position. Although the precise nature of the...Full Text Available
Abstract in english A long-standing debate in the literature is whether attention can form two or more independent spatial foci in addition to the well-known unique spatial focus. There is evidence that voluntary visual attention divides in space. The possibility that this also occurs for automatic visual attention was investigated here. Thirty-six female volunteers were tested. In each trial, a prime stimulus was presented in the left or right visual hemifield. This stimulus was characteriz (more) ed by the blinking of a superior, middle or inferior ring, the blinking of all these rings, or the blinking of the superior and inferior rings. A target stimulus to which the volunteer should respond with the same side hand or a target stimulus to which she should not respond was presented 100 ms later in a primed location, a location between two primed locations or a location in the contralateral hemifield. Reaction time to the positive ...
TSH receptor (TSHR) plays a central role in regulating thyroid function and is targeted by IgGs in Graves’ disease (GD-IgG). Whether TSHR is involved in the pathogenesis of thyroid associated...Full Text Available
Short-hairpin RNA (shRNA)–mediated gene knockdown is a powerful tool for targeted gene silencing and an emerging novel therapeutic strategy. Recent publications, however, reported unexpected...Full Text Available
The Tetrahymena thermophila origin recognition complex (ORC) contains an integral RNA subunit, 26T RNA, which confers specificity to the amplified ribosomal DNA (rDNA) origin by base...Full Text Available
The p21-activated kinases (PAKs), immediate downstream effectors of the small G-proteins of the Rac/cdc42 family, are critical mediators of signaling pathways regulating cellular behaviors and...Full Text Available
This R and D project is planed to supply domestic demands of Mo-99 through fission route, and consequently this project will be expected to rise up utilization of HANARO and KAERI's capability for marketing extension into domestic and oversea radiopharmaceutical market. HEU and LEU target types are decided and designed for fission Mo-99 production in domestic. Experimental study of target fabrication technology was performed and developed processing equipments. And conceptual design of target loading/unloading in/from HANARO device are performed. Tracer test of Mo-99 separation and purification process was performed, test results reach to Mo-99 recovery yield above 80% and decontamination factor above 1600. Combined Mo-99 separation and purification process was decided for hot test scheduled from next year, and performance test was performed. Conceptual design for modification of existing hot cell for fission Mo-99 ...
The identification of the protein targets for dengue virus-specific T lymphocytes may be useful for planning the development of subunit vaccines against dengue. We studied the recognition by murine...Full Text Available
We calculate mass spectrum of CHS model deformed by an exactly marginal operator, and find that there are tachyons which are not localized in the target space. Similar deformation is discussed in another CFT which corresponds to separated NS5-branes. A condensation of the tachyons is briefly argued.
The syntheses and applications of two metallointercalators, Rh(bpy)2(chrysi)3+ and Rh(bpy)2(phzi)3+, that target single base mismatches in DNA are...Full Text Available
Determine the degree to which different precautionary themes are dominant in various target populations and how these themes are acquired. Assess cultural signals of potential danger: are there different kinds of potential danger in different cultures. Do...
ObjectiveFish consumption advisories are issued to warn the public of possible toxicological threats from consuming certain fish species. Although developing fetuses and children...Full Text Available
After emergence, adult flies and other insects select a suitable perch and expand their wings. Wing expansion is governed by the hormone bursicon and can be delayed under adverse environmental...Full Text Available
Cytokinins are distributed through the vascular system and trigger responses of target cells via receptor-mediated signal transduction. Perception and transduction of the signal can occur at the plasma...Full Text Available
BackgroundAs the first pathway-specific enzyme in carotenoid biosynthesis, phytoene synthase (PSY) is a prime regulatory target. This includes a number of biotechnological approaches...Full Text Available
A simple beam-forming system is described for the electrostatic accelerator of the Scientific-Research Institute of Nuclear Physics of Moscow State University. The system allows the beam to be focused on targets at various distances for a conductor potential of from 1 to 4 MV and beam currents of up to 35 #mu# A.
This study used a PCR-based approach targeting 16S rRNA gene fragments to determine the occurrence and association of the three bovine digital dermatitis (BDD) treponeme phylogroups within lesions found...Full Text Available
A goal of our research is to identify biochemical factors that underlie the susceptibility of bone marrow cell populations to benzene metabolites so as to develop a mechanistically based chemoprotective...Full Text Available
BackgroundFormation of site specific genomic double strand breaks (DSBs), induced by the expression of a pair of engineered zinc-finger nucleases (ZFNs), dramatically increases the...Full Text Available
ObjectiveThis study sought to determine whether differential treatment effects in the targeted mechanisms of change and eating disorder (ED) symptoms are associated...Full Text Available
BackgroundMale infertility is a common cause of reproductive failure in humans. In mice, targeted deletions of the genes coding for FKBP6 or FKBP52, members of the FK506 binding...Full Text Available
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Their discovery in the 1990s provided insights...Full Text Available
SUMMARYATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as...Full Text Available
As part of the Nondestructive Evaluation Reliability Program sponsored by the US Nuclear Regulatory Commission, the Pacific Northwest Laboratory is developing a method that uses risk-based approaches to establish in-service inspection plans for nuclear power plant components. This method uses probabilistic risk assessment (PRA) results and Failure Modes and Effects Analysis (FEMA) techniques to identify and prioritize the most risk-important systems and components for inspection. The Surry Nuclear Power Station Unit 1 was selected for pilot applications of this method. The specific systems addressed in this report are the reactor pressure vessel, the reactor coolant, the low-pressure injection, and the auxiliary feedwater. The results provide a risk-based ranking of components within these systems and relate the target risk to target failure probability values for individual components. These results will be used to guide the development of ...
A duplex TaqMan real-time RT-PCR assay was developed for the detection of California (CAL) serogroup viruses and Cache Valley virus (CVV), for use in human surveillance. The targets selected...Full Text Available
Autophagic adapters including p62/SQSTM1 recognize polyubiquitinated autophagic targets such as toxic protein aggregates. Recently reporting in Molecular Cell, Filimonenko et al. provide evidence...Full Text Available
A Bragg curve counter equipped with an internal production target was developed for the measurements of double-differential cross-sections of fragment production induced by neutrons at energies of tens of MeV. The internal target permitted a large detection solid angle and thus the registration of processes at low production rates. In this specific geometry, the detection solid angle depends on the emission angle and the range of the particle. Therefore the energy, atomic number, and angle of trajectory of the particle have to be taken into account for the determination of the solid angle. For the selection of events with tracks confined within a defined cylindrical volume around the detector axis, a segmented anode was applied. The double-differential cross-sections for neutron-induced production of lithium, beryllium, and boron fragments from a carbon target were measured at 0 deg. for 65 MeV neutrons. The results are in ...