WorldWideScience

Sample records for takeuchi approach eqn

  1. Takeuchi. Nuevo híbrido de Dendrobium (Orchidaceae) para Cuba / Takeuchi. New cuban hybrid of Dendrobium (Orchidaceae)

    Scientific Electronic Library Online (English)

    Lorenzo, Suárez Guerra; María M, Hernández Espinosa; Georvis, Téllez Beltrán.

    2013-12-01

    Full Text Available Los Dendrobium forman parte de las orquídeas más cultivadas de todo el mundo; varios cultivares de este género son vendidos como flor de corte y se ubican en el cuarto lugar en ventas entre los productos de floricultura, después de las Palmáceas, Dracaena y Anthurium de corte. En este trabajo se pre [...] sentan las principales características de un nuevo cultivar de orquídea epífita, perteneciente al género Dendrobium. Takeuchi, es el resultado de la polinización manual cruzada realizada en el mes de enero del 2007 entre Dendrobium x superbiens (progenitor madre) y Dendrobium Kuranda Classic (progenitor padre); la primera floración se obtuvo en el mes de enero del 2012. Se encuentra registrado en la base de datos de la Sociedad Hortícola Real de Inglaterra, autoridad internacional encargada del registro de cultivares híbridos de orquídeas. Este nuevo híbrido posee un alto potencial ornamental y estético. Abstract in english The Dendrobium are among the most cultivated orchids worldwide; they are sold as cut flowers and are ranked in the fourth place in sales among floricultural products, after Palms, Dracaena and Anthurium for cut. This paper presents the main characteristics of a new cultivar of epiphytic orchids, bel [...] onging to the genus Dendrobium. Takeuchi becomes from the cross pollination, in January 2007, between Dendrobium x superbiens (female parent) and Dendrobium Kuranda Classic (male parent). The first flowering occurred in January 2012. This hybrid is registered in the database of the Royal Horticultural Society of England, international cultivar registration authority for orchid hybrids. This new hybrid has a high ornamental and esthetic potential.

  2. Technicolor theories with negative values of the Peskin-Takeuchi electroweak parameter S

    Science.gov (United States)

    Luty, Markus A.; Sundrum, Raman

    1993-02-01

    We show that the pseudo Nambu-Goldstone boson contribution to the Peskin-Takeuchi electroweak parameter S can be negative in a class of technicolor theories. This negative contribution can be large enough to cancel the positive technihadron contribution, showing that electroweak precision tests alone cannot be used to rule out technicolor as the mechanism of electroweak symmetry breaking.

  3. Technicolor theories with negative values of the Peskin-Takeuchi electroweak parameter S

    International Nuclear Information System (INIS)

    We show that the pseudo Nambu-Goldstone boson contribution to the Peskin-Takeuchi electroweak parameter S can be negative in a class of technicolor theories. This negative contribution can be large enough to cancel the positive technihadron contribution, showing that electroweak precision tests alone cannot be used to rule out technicolor as the mechanism of electroweak symmetry breaking

  4. Análise da técnica de takeuchi usada para o tratamento da origem anômala da artéria coronária esquerda do tronco pulmonar Analysis of the takeuchi procedure for the treatment of anomalous origin of the left coronary artery from the pulmonary artery

    OpenAIRE

    Andrea Weirich Lenzi; Leo Solarewicz; Wanderley Saviollo Ferreira; Fábio Sallum; Nelson Itiro Miyague

    2008-01-01

    FUNDAMENTO: Avaliação dos casos de origem anômala da artéria coronária esquerda do tronco pulmonar operados com a técnica de Takeuchi, analisando o resultado cirúrgico imediato e tardio e a morbidade destes pacientes. OBJETIVO: Relato uma série de casos de origem anômala da artéria coronária esquerda do tronco pulmonar operados com a técnica de Takeuchi. Métodos: Realizou-se a análise com coleta de dados dos prontuários de doze pacientes submetidos à correção cirúrgica no p...

  5. Existential participation in Reality and the Ontodialogical focus - exemplified with Heidegger's, Takeuchi's and Corbin's interpretation of existence and death

    DEFF Research Database (Denmark)

    Garsdal, Jesper

    2010-01-01

    In this paper I will introduce some standard view on hermeneutics and interpretation. I will present a conceptual distinction between different ideals of truth, in relation if these ideals views on the importance of the "knower's" existential participation in Reality as a central aspect of knowledge the "knower" has. I will inspired by philosophical hermeneutics and Henry Corbin introduce a distinction between gnostic and agnostic ideals of knowledge, acknowledging that both forms of knowledge ideals can be found in different hermeneutical traditions in different faith-traditions in the world, and very often are interwoven in each other. I will then focus on the "gnostic" knowledge ideal by giving a short example of how this knowledge ideal can be applied in different ways in different forms of religious-philosophical ontologies. This implicates also different forms of interpretations of what it means to be human. I will try to illustrate this by presenting three different "gnostic" existential interpretations of death, namely Heidegger's idea of existence (or Dasein) as being-to-death, Tanabe/Takeuchi's Buddhist-inspired idea of existence as being neither-dead-nor-alive, and Henry Corbin's interpretation of existence as constructed by and relating to the other-side-of-death. In relation to Corbin I will further present his view of the word of Mundus Imaginalis as he find this idea developed in Ibn al'-Arabi, the corresponding idea of a geosophical phenomenology of the world-of-the-resurrection-body, as Corbin finds this theme elaborated in pre-Islamic Iranian philosophy and esoteric Islam. I will argue that these ideas areclosely connected to Corbin's attempt to create an interpretational strategy for the three monistic religions, and especially "esoteric Islam". Finally I will reflect on how these different approaches to death is connected, with different possible constructions of not only ontology but also inter-subjectivity (a theme I hopefully will expand on in another paper). I will then present a preliminary idea of ontodialogical difference and indicate how this idea might work in relation to inter-religious dialogue.

  6. Análise da técnica de takeuchi usada para o tratamento da origem anômala da artéria coronária esquerda do tronco pulmonar / Analysis of the takeuchi procedure for the treatment of anomalous origin of the left coronary artery from the pulmonary artery

    Scientific Electronic Library Online (English)

    Andrea Weirich, Lenzi; Leo, Solarewicz; Wanderley Saviollo, Ferreira; Fábio, Sallum; Nelson Itiro, Miyague.

    2008-03-01

    Full Text Available FUNDAMENTO: Avaliação dos casos de origem anômala da artéria coronária esquerda do tronco pulmonar operados com a técnica de Takeuchi, analisando o resultado cirúrgico imediato e tardio e a morbidade destes pacientes. OBJETIVO: Relato uma série de casos de origem anômala da artéria coronária esquerd [...] a do tronco pulmonar operados com a técnica de Takeuchi. Métodos: Realizou-se a análise com coleta de dados dos prontuários de doze pacientes submetidos à correção cirúrgica no período de 1981 a 2003. RESULTADOS: A idade média dos pacientes foi de 5,9 ± 1,7 meses. A clínica preponderante foi insuficiência cardíaca, principalmente nos lactentes. O eletrocardiograma inicial em dez casos mostrou onda Q em DI e aVL e sinais de isquemia miocárdica. No ecocardiograma, observaram-se padrão de miocardiopatia dilatada em seis pacientes e insuficiência mitral. A idade média da correção cirúrgica foi de 31,8 ± 14,3 meses. A mortalidade cirúrgica imediata foi de 16% (dois pacientes) por disfunção cardíaca. No acompanhamento ambulatorial, houve a melhora da sintomatologia e das alterações isquêmicas no eletrocardiograma, retorno da função cardíaca e melhora da insuficiência mitral. Durante o acompanhamento, três casos evoluíram com estenose supravalvar pulmonar. CONCLUSÃO: A suspeita clínica dessa cardiopatia deve ser feita em todo lactente com insuficiência cardíaca. A correção cirúrgica com o emprego da técnica de Takeuchi se mostra eficaz, com baixo índice de mortalidade. Após a correção, há um retorno à normalidade da função cardíaca e a melhora da insuficiência mitral. Abstract in english BACKGROUND: Evaluation of a case series of anomalous origin of the left coronary artery from the pulmonary artery corrected with the Takeuchi procedure, analyzing their immediate and late surgical outcomes as well as the related morbidity. OBJECTIVE: To report a case series of anomalous origin of th [...] e left coronary artery from the pulmonary artery corrected with the Takeuchi procedure. METHODS: The analysis was based on data collected from the medical records of 12 patients undergoing surgical correction between 1981 and 2003. RESULTS: The mean age of the patients was 5.9 ± 1.7 months. The predominant manifestation was heart failure, especially in the infants. The baseline electrocardiogram showed a Q wave in DI and aVL and signs of myocardial ischemia in ten cases. Echocardiogram with a pattern of dilated cardiomyopathy and mitral regurgitation was found in six patients. The mean age at surgical correction was 31.8 ± 14.3 months. The immediate surgical mortality was 16% (two patients), from cardiac dysfunction. In the outpatient follow-up we observed that the symptoms, ischemic electrocardiographic changes, cardiac function and mitral regurgitation improved. Three cases progressed with supravalvar pulmonary stenosis during follow-up. CONCLUSION: This heart disease should be suspected in every infant presenting with heart failure. Surgical correction with the Takeuchi procedure has proven efficient, with a low mortality rate. Cardiac function returns to normal and mitral regurgitation improves after surgical correction.

  7. Análise da técnica de takeuchi usada para o tratamento da origem anômala da artéria coronária esquerda do tronco pulmonar Analysis of the takeuchi procedure for the treatment of anomalous origin of the left coronary artery from the pulmonary artery

    Directory of Open Access Journals (Sweden)

    Andrea Weirich Lenzi

    2008-03-01

    Full Text Available FUNDAMENTO: Avaliação dos casos de origem anômala da artéria coronária esquerda do tronco pulmonar operados com a técnica de Takeuchi, analisando o resultado cirúrgico imediato e tardio e a morbidade destes pacientes. OBJETIVO: Relato uma série de casos de origem anômala da artéria coronária esquerda do tronco pulmonar operados com a técnica de Takeuchi. Métodos: Realizou-se a análise com coleta de dados dos prontuários de doze pacientes submetidos à correção cirúrgica no período de 1981 a 2003. RESULTADOS: A idade média dos pacientes foi de 5,9 ± 1,7 meses. A clínica preponderante foi insuficiência cardíaca, principalmente nos lactentes. O eletrocardiograma inicial em dez casos mostrou onda Q em DI e aVL e sinais de isquemia miocárdica. No ecocardiograma, observaram-se padrão de miocardiopatia dilatada em seis pacientes e insuficiência mitral. A idade média da correção cirúrgica foi de 31,8 ± 14,3 meses. A mortalidade cirúrgica imediata foi de 16% (dois pacientes por disfunção cardíaca. No acompanhamento ambulatorial, houve a melhora da sintomatologia e das alterações isquêmicas no eletrocardiograma, retorno da função cardíaca e melhora da insuficiência mitral. Durante o acompanhamento, três casos evoluíram com estenose supravalvar pulmonar. CONCLUSÃO: A suspeita clínica dessa cardiopatia deve ser feita em todo lactente com insuficiência cardíaca. A correção cirúrgica com o emprego da técnica de Takeuchi se mostra eficaz, com baixo índice de mortalidade. Após a correção, há um retorno à normalidade da função cardíaca e a melhora da insuficiência mitral.BACKGROUND: Evaluation of a case series of anomalous origin of the left coronary artery from the pulmonary artery corrected with the Takeuchi procedure, analyzing their immediate and late surgical outcomes as well as the related morbidity. OBJECTIVE: To report a case series of anomalous origin of the left coronary artery from the pulmonary artery corrected with the Takeuchi procedure. METHODS: The analysis was based on data collected from the medical records of 12 patients undergoing surgical correction between 1981 and 2003. RESULTS: The mean age of the patients was 5.9 ± 1.7 months. The predominant manifestation was heart failure, especially in the infants. The baseline electrocardiogram showed a Q wave in DI and aVL and signs of myocardial ischemia in ten cases. Echocardiogram with a pattern of dilated cardiomyopathy and mitral regurgitation was found in six patients. The mean age at surgical correction was 31.8 ± 14.3 months. The immediate surgical mortality was 16% (two patients, from cardiac dysfunction. In the outpatient follow-up we observed that the symptoms, ischemic electrocardiographic changes, cardiac function and mitral regurgitation improved. Three cases progressed with supravalvar pulmonary stenosis during follow-up. CONCLUSION: This heart disease should be suspected in every infant presenting with heart failure. Surgical correction with the Takeuchi procedure has proven efficient, with a low mortality rate. Cardiac function returns to normal and mitral regurgitation improves after surgical correction.

  8. Charged Particle in a Time-dependent Electric Field: A White Noise Functional Approach

    International Nuclear Information System (INIS)

    The propagator for a charged particle in a time-dependent electric field is calculated following Hida and Streit's framework where the propagator is the T-transform of Feynman functional. However, we have to regard the potential V = -qE(?)x??((m/(?/2?)))?x following C. C. Bernido and M. V. Carpio-Bernido's prescription of time-dependent potentials. The result agrees with the limiting form of Eqn. (16) of N. Morgenstern Horing, H. L. Cui, and G. Fiorenza, when the magnetic field is switched off, and Eqn. (17) of [3] when the electric field is constant in time

  9. A Language to Enable Distributed Simulation of Extended Queueing Networks

    Directory of Open Access Journals (Sweden)

    Daniele Gianni

    2007-06-01

    Full Text Available Distributed simulators are increasingly being used for their intrinsic advantages in terms of reusability, fault tolerance, performance, and geographic distribution. The development of a distributed simulator, however, requires significant investments in terms of effort if compared to the development of traditional local simulators. This paper introduces jEQN, a Java-based language that significantly reduces the extra effort needed to develop a distributed simulator of extended queueing networks (EQNs, by enabling simulator developers to build distributed simulators as they were to be locally executed. By use of jEQN, simulator developers are enabled to easily switch from a local to a distributed version of an EQN simulator by only modifying few statements of the given local simulator. Moreover, these statements can be easily inferred by a very intuitive graphical procedure. The paper illustrates both the jEQN architecture, based on a layered approach, and the implementation details that contribute to achieve the above mentioned advantages.

  10. Narrative approaches

    DEFF Research Database (Denmark)

    Stelter, Reinhard

    2012-01-01

    Narrative coaching is representative of the new wave – or third generation – of coaching practice . The theory and practice of narrative coaching takes into account the social and cultural conditions of late modern society, and must be seen as intertwined with them. Some initial conceptualizations of narrative coaching were developed by David Drake (2006, 2007, 2008, 2009) in the USA and Australia, by Ho Law in the UK (Law, 2007a + b; Law & Stelter, 2009) and by Reinhard Stelter (2007, 2009, 2012, in preparation; Stelter & Law, 2010) in Denmark. In the following chapter the aim is to present coaching as a narrative-collaborative practice, an approach that is based on phenomenology, social constructionism and narrative theory. Seeing narrative coaching as a collaborative practice also leads to reflecting on the relationship between coach and coachee(s) in a new way, where both parts contribute to the dialogue equally and sometimes even symmetrically. The practice of narrative coaching will be examined in relation to the concrete experiences gained in a related field of practice, i.e. narrative therapy (White, 1997, 2007). Narrative coaching is to be understood as a reflective space, either of an individual or of a group or team, where the main focus is on values and on providing opportunities for meaning-making. Problematic experiences or events are reframed by the unfolding of alternative narratives; these are based on re-experiencing and re-collection, as well as on the process of co-creation between coach and coachee. The conceptual framework will be tested by presenting central results of a research project. The ideas discussed in this chapter expand upon earlier concepts of the narrative approach (mainly formulated by White in 2007) by integrating ideas from phenomenology and experiential approaches with collaborative and social constructionist thinking.

  11. Curriculum: Which Approach?

    Science.gov (United States)

    Rulloda, Rudolfo Barcena

    2010-01-01

    Curriculum has two major approaches, technical and scientific approach and the nontechnical-nonscientific approach. Both are different and distinct. Schools need to distinguish which approach is suited for their students.

  12. Nuclear knowledge preservation of Atucha type Reactor: Practical approaches and lessons learned

    International Nuclear Information System (INIS)

    Full text: The nuclear option is born in Argentina in 1950. Since then and after half century, the Argentine nuclear sector reaches a hierarchy and an important technological - scientific dimension in all the issues related to activities linked to the nuclear sector. The export of research reactors, the nuclear fuel production and the installation of nucleoelectrical power stations constitute one of the most outstanding achievements of this activity. The Atucha I Nuclear Power Plant, of Siemens-KWU technology with 30 years of operation and Embalse (Candu type) with 20 years of operation, register an efficient and safe performance, within the worldwide standards. In addition, and with Siemens technology the Atucha II NPP is in construction with a 82% of work advance. At the moment Siemens, has transferred his place as designer of reactors LWR to the Framatom ANP Company and consequently Argentina will have to make all the efforts to assure the 'knowledge preservation' of the technology of this line of reactors, if it hopes that Atucha I extends its useful life and Atucha II is finalized. Likewise the aging of the personnel in the sector is worrisome being numerous the great number of people who are close to retire what it worsens if we think that there are a few young people able in this specialty by the lack of the entrance of candidates in compatible races This situation generated the necessity to implement a system of Knowledge Management to capture and to capitalizdge Management to capture and to capitalize the tacit and explicit knowledge, to spread it and to share by using techniques and tools adapted through the organization. Practical Approaches and Lessons Learned: A - Analysis of the strategy: The strategy was based on recognizing the critical knowledge by means of the use of a methodology that incorporates the technique of the map of the critical knowledge. That is to say, to recognize the patrimony of the knowledge around the reactor. The layout of the knowledge map of reactor together with the systematic analysis of criticalities generated the architecture of the taxonomies of reactor Atucha type behavior as also it allowed to carried out its own actions of the knowledge management from the diagnosis of the it where proposals and actions arise destined to reduce the criticality and to put into operation the different processes system. (Cycle of Nonaka and Takeuchi) B. - Technical of development and its disadvantages: Factors of analysis How to restore a new methodology that requires of the application of techniques for personal and group interviews. It is essential to consider this time at the time of project planning. The project demands much interaction with experts of different profiles and availability of their time because it involves to all the nuclear sector and the complete service life of the Reactor (project, design, operation, decommissioning, dismantling). Effects of the operation state of plant in the accomplishment of different activities from the project The infrastructure of the ITC of different generations that coexist can force to generate migrations of information and to develop new additional tools. The limited HHRR, financial resources, the administrative circuits, the different corporative cultures that coexist and the critical knowledge that keeps in mind of people close to get their retirement, require of an exhaustive previous analysis to determine their influence in the criticality of the system. (author)

  13. Approaches to curriculum planning.

    Science.gov (United States)

    Harden, R M

    1986-09-01

    This booklet describes different ways used to tackle the problem of curriculum planning. By studying these approaches teachers can get an insight into the process in their own school. First they must decide whether there should be a particular focus for curriculum planning and if so what it should be. In the light of this they can modify their school's approach. To what extent do they wish to focus on: aims and objectives (engineering approach), teaching methods (mechanics approach), content (cookbook approach), timetable (railway approach), problems (detective approach), one idea or strategy (religious approach), the regulations (bureaucratic approach), or a curriculum designed to attract sponsorship (public relations approach)? The magician approach, in which it is not clear how a curriculum is developed, is not recommended. Second, what should be the pattern of staff involvement--a representative group or committee (United Nations approach), all the teachers (people's congress approach), one individual (the dictator approach), a collaboration with students, patients and other professional colleagues (consumer approach), or a collaboration with an external consultant (consultant approach)? Whichever approach is adopted, advantages should be maximized and deficiencies minimized. PMID:3531778

  14. RESEARCH APPROACH: AN OVERVIEW

    Directory of Open Access Journals (Sweden)

    Vijay Kumar Grover

    2015-02-01

    Full Text Available The paper attempts to explain different possible research approaches to pursue a research project. It starts with three important components of a research approach amelyphilosophical world view, research design, and research methods. Research approaches are classified on the basis of work of Guba (1990, which puts it in to the categories of post positivism, constructivism, transformative and pragmatism. Further paper explains salient features and principals of these four world views. These world views are merged to form three approaches namely-quantitative, qualitative and mixed methods. Quantitative approach includes positivism and post positivism world view, qualitative approach includes constructivism and transformative world view and mixed method approach corresponds to pragmatism. Beside these approaches two more approaches has been discussed namely-Logical, theoretical research used in the field of mathematics and computer science and Participatory action research used in the field of management, sociology and anthropology. Paper finally ends with criterion for choosing a research approach. In concluding remarks author stresses that all the approaches are complementary to each other rather than opposing each other. No concept or phenomena can be studied by single approach, a combination of these is necessary to uncover the truth.

  15. Evaluating Six Soft Approaches

    DEFF Research Database (Denmark)

    SØrensen, Lene Tolstrup; Valqui Vidal, René Victor

    2008-01-01

    The paper introduces and evaluates six soft approaches used in strategy development and planning. We take a planner's perspective on discussing the concepts of strategy development and planning. This means that we see strategy development and planning as learning processes based on Ackoff's interactive planning principles to be supported by soft approaches in carrying out the principles in action. These six soft approaches are suitable forsupporting various steps of the strategy development and planning process. These are the SWOT analysis, the Future Workshop, the Scenario methodology, Strategic Option Development and Analysis, Strategic Choice Approach and Soft Systems Methodology. Evaluations of each methodology are carried out using a conceptual framework in which the organisation, the result, the process and the technology of the specific approach are taken into consideration. Using such a conceptual framework for evaluations of soft approaches increases the understanding of them, their transparency, andtheir usability in practice.

  16. Evaluating six soft approaches

    DEFF Research Database (Denmark)

    SØrensen, Lene Tolstrup; Vidal, Rene Victor Valqui

    2008-01-01

    The paper introduces and evaluates six soft approaches used in strategy development and planning. We take a planner's perspective on discussing the concepts of strategy development and planning. This means that we see strategy development and planning as learning processes based on Ackoff's interactive planning principles to be supported by soft approaches in carrying out the principles in action. These six soft approaches are suitable forsupporting various steps of the strategy development and planning process. These are the SWOT analysis, the Future Workshop, the Scenario methodology, Strategic Option Development and Analysis, Strategic Choice Approach and Soft Systems Methodology. Evaluations of each methodology are carried out using a conceptual framework in which the organisation, the result, the process and the technology of the specific approach are taken into consideration. Using such a conceptual framework for evaluations of soft approaches increases the understanding of them, their transparency, andtheir usability in practice.

  17. Evaluating six soft approaches

    Directory of Open Access Journals (Sweden)

    Lene Sørensen

    2008-09-01

    Full Text Available The paper introduces and evaluates six soft approaches used in strategy development and planning. We take a planner’s perspective on discussing the concepts of strategy development and planning. This means that we see strategy development and planning as learning processes based on Ackoff’s interactive planning principles to be supported by soft approaches in carrying out the principles in action. These six soft approaches are suitable for supporting various steps of the strategy development and planning process. These are the SWOT analysis, the Future Workshop, the Scenario methodology, Strategic Option Development and Analysis, Strategic Choice Approach and Soft Systems Methodology. Evaluations of each methodology are carried out using a conceptual framework in which the organisation, the result, the process and the technology of the specific approach are taken into consideration. Using such a conceptual framework for evaluations of soft approaches increases the understanding of them, their transparency, and their usability in practice.

  18. The NLERAP Approach

    Science.gov (United States)

    Nieto, Sonia; Rivera, Melissa; Irizarry, Jason

    2012-01-01

    From the start, NLERAP has been based on two major premises: one is that a sociocultural and sociopolitical approach to learning is more effective than a traditional approach, particularly in the case of populations that have historically been marginalized through their education; and the second is that research is more meaningful and inclusive…

  19. The TLC Approach.

    Science.gov (United States)

    Welker, William A.

    2002-01-01

    Notes how the author has developed the Teaching and Learning Cues (TLC) approach, an offspring of textbook organizational patterns instruction that stresses the significance of certain words and phrases in reading. Concludes that with the TLC approach, students learn to appreciate the important role cue words and phrases play in understanding…

  20. Life Span Developmental Approach

    Directory of Open Access Journals (Sweden)

    Ali Eryilmaz

    2011-03-01

    Full Text Available The Life Span Developmental Approach examines development of individuals which occurs from birth to death. Life span developmental approach is a multi-disciplinary approach related with disciplines like psychology, psychiatry, sociology, anthropology and geriatrics that indicates the fact that development is not completed in adulthood, it continues during the life course. Development is a complex process that consists of dying and death. This approach carefully investigates the development of individuals with respect to developmental stages. This developmental approach suggests that scientific disciplines should not explain developmental facts only with age changes. Along with aging, cognitive, biological, and socioemotional development throughout life should also be considered to provide a reasonable and acceptable context, guideposts, and reasonable expectations for the person. There are three important subjects whom life span developmental approach deals with. These are nature vs nurture, continuity vs discontinuity, and change vs stability. Researchers using life span developmental approach gather and produce knowledge on these three most important domains of individual development with their unique scientific methodology.

  1. The case study approach

    OpenAIRE

    Huby Guro; Robertson Ann; Cresswell Kathrin; Crowe Sarah; Avery Anthony; Sheikh Aziz

    2011-01-01

    Abstract The case study approach allows in-depth, multi-faceted explorations of complex issues in their real-life settings. The value of the case study approach is well recognised in the fields of business, law and policy, but somewhat less so in health services research. Based on our experiences of conducting several health-related case studies, we reflect on the different types of case study design, the specific research questions this approach can help answer, the data sources that tend to...

  2. ECOTOXICOLOGY: PROBLEMS AND APPROACHES

    Science.gov (United States)

    In today's chemical-oriented society, any student of ecology must be cognizant of the potential for environmental toxicants to alter the balances and relationships among the plants, animals and biogeochemical cycles in an ecosystem. Ecotoxicology: roblems and Approaches" provides...

  3. Behavioral based safety approaches

    International Nuclear Information System (INIS)

    Approach towards the establishment of positive safety culture at Heavy Water Plant, Tuticorin includes the adoption of several important methodologies focused on human behavior and culminates with achievement of Total Safety Culture where Quality and Productivity are integrated with Safety

  4. ??? ?????????? ??? ??????? ??? ????? ??? Approaches (2009-2011

    Directory of Open Access Journals (Sweden)

    ??????? ??????

    2011-01-01

    Full Text Available This year, in May 2011, the journal Approaches: Music Therapy & Special Music Education successfully completes two years of publications. On the occasion of this anniversary, this article presents a review of Approaches’ work, publications and broader actions from 2009 onwards. This review attempts to outline the profile of the journal in Greece and abroad, as this has been formed during the first years of its life. In this context an analysis of Approaches’ publications is made, according to various indicators and criteria: publication categories, types of articles, scientific fields, publication languages, and authors’ countries of origin. Taking into consideration that Approaches is the first (and the only until now journal for music therapy and special music education in Greece, the outcomes emerging from this review and analysis are not limited to the journal. These outcomes offer useful indications for the broader situation and development of the respective fields in Greece.

  5. File System Design Approaches

    OpenAIRE

    Brijender Kahanwal

    2014-01-01

    In this article, the file system development design approaches are discussed. The selection of the file system design approach is done according to the needs of the developers what are the needed requirements and specifications for the new design. It allowed us to identify where our proposal fitted in with relation to current and past file system development. Our experience with file system development is limited so the research served to identify the different techniques th...

  6. Financial Management: An Organic Approach

    Science.gov (United States)

    Laux, Judy

    2013-01-01

    Although textbooks present corporate finance using a topical approach, good financial management requires an organic approach that integrates the various assignments financial managers confront every day. Breaking the tasks into meaningful subcategories, the current article offers one approach.

  7. File System Design Approaches

    Directory of Open Access Journals (Sweden)

    Brijender Kahanwal

    2014-02-01

    Full Text Available In this article, the file system development design approaches are discussed. The selection of the file system design approach is done according to the needs of the developers what are the needed requirements and specifications for the new design. It allowed us to identify where our proposal fitted in with relation to current and past file system development. Our experience with file system development is limited so the research served to identify the different techniques that can be used. The variety of file systems encountered show what an active area of research file system development is. The file systems may be from one of the two fundamental categories. In one category, the file system is developed in user space and runs as a user process. Another file system may be developed in the kernel space and runs as a privileged process. Another one is the mixed approach in which we can take the advantages of both aforesaid approaches. Each development option has its own pros and cons. In this article, these design approaches are discussed.

  8. Technical approach document

    Energy Technology Data Exchange (ETDEWEB)

    1989-12-01

    The Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law 95-604 (PL95-604), grants the Secretary of Energy the authority and responsibility to perform such actions as are necessary to minimize radiation health hazards and other environmental hazards caused by inactive uranium mill sites. This Technical Approach Document (TAD) describes the general technical approaches and design criteria adopted by the US Department of Energy (DOE) in order to implement remedial action plans (RAPS) and final designs that comply with EPA standards. It does not address the technical approaches necessary for aquifer restoration at processing sites; a guidance document, currently in preparation, will describe aquifer restoration concerns and technical protocols. This document is a second revision to the original document issued in May 1986; the revision has been made in response to changes to the groundwater standards of 40 CFR 192, Subparts A--C, proposed by EPA as draft standards. New sections were added to define the design approaches and designs necessary to comply with the groundwater standards. These new sections are in addition to changes made throughout the document to reflect current procedures, especially in cover design, water resources protection, and alternate site selection; only minor revisions were made to some of the sections. Sections 3.0 is a new section defining the approach taken in the design of disposal cells; Section 4.0 has been revised to include design of vegetated covers; Section 8.0 discusses design approaches necessary for compliance with the groundwater standards; and Section 9.0 is a new section dealing with nonradiological hazardous constituents. 203 refs., 18 figs., 26 tabs.

  9. Technical approach document

    International Nuclear Information System (INIS)

    The Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law 95-604 (PL95-604), grants the Secretary of Energy the authority and responsibility to perform such actions as are necessary to minimize radiation health hazards and other environmental hazards caused by inactive uranium mill sites. This Technical Approach Document (TAD) describes the general technical approaches and design criteria adopted by the US Department of Energy (DOE) in order to implement remedial action plans (RAPS) and final designs that comply with EPA standards. It does not address the technical approaches necessary for aquifer restoration at processing sites; a guidance document, currently in preparation, will describe aquifer restoration concerns and technical protocols. This document is a second revision to the original document issued in May 1986; the revision has been made in response to changes to the groundwater standards of 40 CFR 192, Subparts A--C, proposed by EPA as draft standards. New sections were added to define the design approaches and designs necessary to comply with the groundwater standards. These new sections are in addition to changes made throughout the document to reflect current procedures, especially in cover design, water resources protection, and alternate site selection; only minor revisions were made to some of the sections. Sections 3.0 is a new section defining the approach taken in the design of disposal cells; Section 4.0 has been revised to include design of vegetated covers; Section 8.0 discusses design approaches necessary for compliance with the groundwater standards; and Section 9.0 is a new section dealing with nonradiological hazardous constituents. 203 refs., 18 figs., 26 tabs

  10. Homogenization approach in engineering

    International Nuclear Information System (INIS)

    Homogenization is an approach which studies the macrobehavior of a medium by its microproperties. Problems with a microstructure play an essential role in such fields as mechanics, chemistry, physics, and reactor engineering. Attention is concentrated on a simple specific model problem to illustrate results and problems typical of the homogenization approach. Only the diffusion problem is treated here, but some statements are made about the elasticity of composite materials. The differential equation is solved for linear cases with and without boundaries and for the nonlinear case. 3 figures, 1 table

  11. Skill Clinics: Community Approaches.

    Science.gov (United States)

    Office of Vocational and Adult Education (ED), Washington, DC.

    Intended for people interested in developing a skill clinic, this document contains examples of community and workplace approaches to skill clinics. It describes skill clinics that make it easier for adults to pursue further education and training by offering one-stop service, coordination, assessment, referral, and career counseling. Nine…

  12. Approaches to acceptable risk

    Energy Technology Data Exchange (ETDEWEB)

    Whipple, C.

    1997-04-30

    Several alternative approaches to address the question {open_quotes}How safe is safe enough?{close_quotes} are reviewed and an attempt is made to apply the reasoning behind these approaches to the issue of acceptability of radiation exposures received in space. The approaches to the issue of the acceptability of technological risk described here are primarily analytical, and are drawn from examples in the management of environmental health risks. These include risk-based approaches, in which specific quantitative risk targets determine the acceptability of an activity, and cost-benefit and decision analysis, which generally focus on the estimation and evaluation of risks, benefits and costs, in a framework that balances these factors against each other. These analytical methods tend by their quantitative nature to emphasize the magnitude of risks, costs and alternatives, and to downplay other factors, especially those that are not easily expressed in quantitative terms, that affect acceptance or rejection of risk. Such other factors include the issues of risk perceptions and how and by whom risk decisions are made.

  13. Orion Emergency Mask Approach

    Science.gov (United States)

    Tuan, George C.; Graf, John C.

    2009-01-01

    Emergency mask approach on Orion poses a challenge to the traditional Shuttle or Station approaches. Currently, in the case of a fire or toxic spill event, the crew utilizes open loop oxygen masks that provide the crew with oxygen to breath, but also dumps the exhaled oxygen into the cabin. For Orion, with a small cabin volume, the extra oxygen will exceed the flammability limit within a short period of time, unless a nitrogen purge is also provided. Another approach to a fire or toxic spill event is the use of a filtering emergency masks. These masks utilize some form of chemical beds to scrub the air clean of toxic providing the crew safe breathing air for a period without elevating the oxygen level in the cabin. Using the masks and a form of smoke-eater filter, it may be possible to clean the cabin completely or to a level for safe transition to a space suit to perform a cabin purge. Issues with filters in the past have been the reaction time, breakthroughs, and high breathing resistance. Development in a new form of chemical filters has shown promise to make the filtering approach feasible.

  14. Approaches to acceptable risk

    International Nuclear Information System (INIS)

    Several alternative approaches to address the question open-quotes How safe is safe enough?close quotes are reviewed and an attempt is made to apply the reasoning behind these approaches to the issue of acceptability of radiation exposures received in space. The approaches to the issue of the acceptability of technological risk described here are primarily analytical, and are drawn from examples in the management of environmental health risks. These include risk-based approaches, in which specific quantitative risk targets determine the acceptability of an activity, and cost-benefit and decision analysis, which generally focus on the estimation and evaluation of risks, benefits and costs, in a framework that balances these factors against each other. These analytical methods tend by their quantitative nature to emphasize the magnitude of risks, costs and alternatives, and to downplay other factors, especially those that are not easily expressed in quantitative terms, that affect acceptance or rejection of risk. Such other factors include the issues of risk perceptions and how and by whom risk decisions are made

  15. The transzygomatic approach.

    Science.gov (United States)

    Campero, Alvaro; Campero, A Agustín; Socolovsky, Mariano; Martins, Carolina; Yasuda, Alexandre; Basso, Armando; Rhoton, Albert

    2010-11-01

    We aim to describe the technical details of the transzygomatic approach to intracranial surgery. The incision begins at the level of the inferior border of the zygomatic arch, anterior to the tragus, and extends towards the contralateral pupillary line. A subgaleal and interfascial dissection is performed. Then, the zygomatic arch is vertically sectioned twice and mobilized downwards, together with the masseter muscle. Next, a fronto-temporo-sphenoidal craniotomy is performed and complete exposure of the anterior temporal dura achieved. Thus, the surgical possibilities are: (i) intradural access to the middle fossa; (ii) intradural pretemporal access to the basal cisterns; (iii) intradural transtemporal access to the insular region; and (iv) extradural access to the middle fossa. The transzygomatic approach offers excellent exposure to the floor of the middle fossa and the lateral wall of the cavernous sinus (both intradurally and extradurally). Also, combined with a pretemporal approach, it affords a good view of the interpeduncular cistern; and using a transtemporal approach, it provides good access to the insular region. PMID:20692168

  16. RFID: Dynamic Surveillance Approach

    Directory of Open Access Journals (Sweden)

    Indraveer Singh

    2010-05-01

    Full Text Available Most of the modern security and monitoring domain is based upon Camera based Surveillance Architecture. Prison cells, corporate offices, government buildings, stock market, supermarkets etc all the seats utilize this structure in core. Most CCTV systems are used for surveillance which can include security monitoring, spying or for safety monitoring purposes. Although this system has been quite popular being affordable and visually administrable, it is no exception to improvements and up gradation. Thus in this paper we have come up with efficient proposals to upgrade the approach for Camera based Surveillance Architecture for security and Administration. This renewed approach is essentially based upon RFID technology where we are utilizing RFID tags and their readers as basic components. Unlike Camera-based surveillance, RFID-based approach can monitor and administer a quarter not only within some region of visibility but can efficiently do the same for locating the individuality (through Dynamic Surveillance as explained further. This approach emphasizes not only on overcoming the demerits of observation-based supervision, but it presents easier and effective monitoring methodologies using radio waves and their usable features in security and administration for areas with consumer pour out.

  17. Multiobjective calibration for comparing channel sediment routing models in the soil and water assessment tool.

    Science.gov (United States)

    Lu, Shenglan; Kayastha, Nagendra; Thodsen, Hans; van Griensven, Ann; Andersen, Hans Estrup

    2014-01-01

    Sediment transport is important for ecology and water quality in receiving waters. Physically based channel erosion methods were implemented in the Soil and Water Assessment Tool version 2009 (SWAT2009) to improve sediment concentration (SS) results. In the study, the default simplified Bagnold sediment routing method (EQN-0) and the physically based simplified Bagnold sediment routing method (EQN-1) were compared with Pareto fronts from multiobjective calibration. Two SWAT models using EQN-0 and EQN-1 were set up for a small agricultural Danish catchment and calibrated with multiobjective calibration on daily and weekly flow-weighted SS (WF SS). Results showed that the Pareto front of EQN-1 was slightly closer to the optimal point than EQN-0 in the objective space. Trade-off between WF SS and daily flow in EQN-1 was smaller than in EQN-0. The EQN-0 method generated more surface erosion to improve WF SS. The EQN-1 method generated more base flow to improve WF SS. The EQN-1 method was less dependent on surface erosion and simulated peak and low values of WF SS better than EQN-0. Therefore, EQN-1 is more suitable than EQN-0 in modeling SS in small lowland catchments. PMID:25602545

  18. The Knowledge Governance Approach

    DEFF Research Database (Denmark)

    Foss, Nicolai

    2005-01-01

    An attempt is made to characterize a `knowledge governance approach' as a distinctive, emerging field that cuts across the fields of knowledge management, organisation studies, strategy and human resource management. Knowledge governance is taken up with how the deployment of administrative apparatus influences knowledge processes, such as sharing, retaining and creating knowledge. It insists on clear behavioural foundations, adopts an economizing perspective and examines efficient alignment between knowledge transactions with diverse characteristics and governance structures and mechanisms with diverse capabilities of handling these transactions. Various open research issues that a knowledge governance approach may illuminate are sketched. Although knowledge governance draws clear inspiration from organizational economics and `rational' organization theory, it recognizes that knowledge represents various challenges to more `closed' social science disciplines, notably economics.

  19. Thermodynamics an engineering approach

    CERN Document Server

    Cengel, Yunus A

    2014-01-01

    Thermodynamics, An Engineering Approach, eighth edition, covers the basic principles of thermodynamics while presenting a wealth of real-world engineering examples so students get a feel for how thermodynamics is applied in engineering practice. This text helps students develop an intuitive understanding by emphasizing the physics and physical arguments. Cengel and Boles explore the various facets of thermodynamics through careful explanations of concepts and use of numerous practical examples and figures, having students develop necessary skills to bridge the gap between knowledge and the confidence to properly apply their knowledge. McGraw-Hill is proud to offer Connect with the eighth edition of Cengel/Boles, Thermodynamics, An Engineering Approach. This innovative and powerful new system helps your students learn more efficiently and gives you the ability to assign homework problems simply and easily. Problems are graded automatically, and the results are recorded immediately. Track individual stude...

  20. Approaching Service Innovation Patterns

    OpenAIRE

    Nagy, Andrea

    2013-01-01

    The present paper aims at analyzing the types of innovation in the field of services. First, the concept of innovation is defined and second, field literature is reviewed from the perspective of service innovation. The main types of innovation are identified based on several attempts at defining innovation, the most notable being Schumpeter’s. Thus, it is possible to approach concepts such as product and process innovation, incremental and radical innovation. Another aim has been to regard ...

  1. Approaching comparative company law

    OpenAIRE

    Donald, David C.

    2008-01-01

    This paper identifies some common errors that occur in comparative law, offers some guidelines to help avoid such errors, and provides a framework for entering into studies of the company laws of three major jurisdictions. The first section illustrates why a conscious approach to comparative company law is useful. Part I discusses some of the problems that can arise in comparative law and offers a few points of caution that can be useful for practical, theoretical and legislative comparative ...

  2. Thyroidectomy - A new approach

    International Nuclear Information System (INIS)

    A new approach in thyroidectomy to treat the thyroid pathologies is reported here. By this new technique, a total of 20 cases were operated with good outcome. The postoperative complications were seen in 05 patients. One patient developed transient recurrent laryngeal nerve palsy and hypertrophic scar in 4 cases. This technique can well be utilized for middle aged and elderly patients having unilateral benign goiter and for ablation of remnants of thyroid gland in malignant disorders. (author)

  3. Conceptual Approach To Architecture ????? ?? ????????? ????????? ????????? ???????

    Directory of Open Access Journals (Sweden)

    Badi alAbed

    2010-12-01

    Full Text Available This paper argues that architectural interpretation is experiencing from abuse use of architectural key terms. Notions like: criticism, history and theory; concepts like: beginning and approach; and labels like: style, school and movement were used indiscriminately in architectural interpretation.For instance, Banham (1966:10 indicated that he interpreted New Brutalism as a movement before the conditions of forming a movement were existed. Jencks writings are another example for the abuse use of the former notions, concepts and labels. In his two books: The Language Of Post-Modern Architecture and Late Modern Architecture, he described Post-Modern Architecture: first as a movement, second as a style, third as a school and fourth as an approach. Banham and Jencks were attempting to formulate verbal equivalent to the design of some architects before it was tested and proved to deserve a theoretical coverage, organized in an intellectual discipline as an approach, school or movement. This attempt perhaps, caused this abuse use of the former key terms in architectural interpretation. Commercial architectural press was another source for the abuse use of the previous architectural key terms. As a case in point, the magazine of Architectural Design (AD was a major source of the misinterpretation of those notions, concepts and labels, over the past four decades. It seems that no considerations were made to the specific definitions of those key terms, nor to the scope of their conceptual meaning, limits and context of their theme. Thus this paper endeavors to clear the abuse use of those notions, concepts and labels in architectural interpretation via defining them, refining their conceptual meanings. And exploring their themes, outlining their role, scope and place within architectural interpretation in order to employ them appropriately within architectural interpretation, as they constitute basic themes of the conceptual world of architecture. In so doing an attempt will be made to investigate the origin, structure, meaning and definitions of the said key terms as indicated in key literary, philosophical and architectural sources. Another attempt will be made to highlight the process and emphasize the conditions of forming and establishing architectural approaches, schools and movements via the concept beginning - as a moment in time and as a project underway - as interpreted in architectural sources. It is important to indicate that investigations in this paper are limited only to the notions: criticism, history and theory; concepts: beginning and approach; and labels: style, school and movement; though investigations will include concepts like precedence, generality and creativity, but within the previous architectural key terms.

  4. Peritonitis: laparoscopic approach

    Directory of Open Access Journals (Sweden)

    Agresta Ferdinando

    2006-03-01

    Full Text Available Abstract Background Laparoscopy has became as the preferred surgical approach to a number of different diseases because it allows a correct diagnosis and treatment at the same time. In abdominal emergencies, both components of treatment – exploration to identify the causative pathology and performance of an appropriate operation – can often be accomplished via laparoscopy. There is still a debate of peritonitis as a contraindication to this kind of approach. Aim of the present work is to illustrate retrospectively the results of a case-control experience of laparoscopic vs. open surgery for abdominal peritonitis emergencies carried out at our institution. Methods From January 1992 and January 2002 a total of 935 patients (mean age 42.3 ± 17.2 years underwent emergent and/or urgent surgery. Among them, 602 (64.3% were operated on laparoscopically (of whom 112 -18.7% – with peritonitis, according to the presence of a surgical team trained in laparoscopy. Patients with a history of malignancy, more than two previous major abdominal surgeries or massive bowel distension were not treated Laparoscopically. Peritonitis was not considered contraindication to Laparoscopy. Results The conversion rate was 23.2% in patients with peritonitis and was mainly due to the presence of dense intra-abdominal adhesions. Major complications ranged as high as 5.3% with a postoperative mortality of 1.7%. A definitive diagnosis was accomplished in 85.7% (96 pat. of cases, and 90.6% (87 of these patients were treated successfully by Laparoscopy. Conclusion Even if limited by its retrospective feature, the present experience let us to consider the Laparoscopic approach to abdominal peritonitis emergencies a safe and effective as conventional surgery, with a higher diagnostic yield and allows for lesser trauma and a more rapid postoperative recovery. Such features make Laparoscopy a challenging alternative to open surgery in the management algorithm for abdominal peritonitis emergencies.

  5. Repository program licensing approach

    International Nuclear Information System (INIS)

    Yucca Mountain, Nevada is currently being studied by the US Department of Energy (DOE) as a potential site for a mined geologic repository for high-level nuclear waste. DOE has the responsibility to determine the suitability of the site and to develop a license application (LA) for authorization to construct the potential repository. If the site is suitable, the license application would be submitted to the US Nuclear Regulatory Commission (NRC). The repository program licensing approach is focused on the timely acquisition of information needed in licensing and the resolution of potential licensing issues with the NRC staff. Licensing involves an iterative process requiring refinements as data are acquired, analyzed, and evaluated. The repository licensing approach presented in this paper ensures that the information is available when needed to facilitate the licensing process. Identifying the information needed to evaluate compliance with the performance objectives in 10 CFR 60, monitoring the acquisition of such information, and developing a successful license application are integral elements of DOE's repository program licensing approach. Activities to characterize the site are being systematically conducted as planned in the Site Characterization Plan (SCP). In addition, DOE is implementing the issue resolution initiative, the license application annotated outline (LAAO) process, and interim licensability evaluations to update the early planning in the SCP and tupdate the early planning in the SCP and to focus site characterization, design, and performance assessment activities on the acquisition of information needed for a site suitability determination and licensing. Collectively, the issue resolution initiative, LAAO process, and interim licensability evaluations are key elements of a transition to the iterative process to answer the question: open-quotes When do we have enough data to support licensing?close quotes

  6. HEDR modeling approach

    International Nuclear Information System (INIS)

    This report details the conceptual approaches to be used in calculating radiation doses to individuals throughout the various periods of operations at the Hanford Site. The report considers the major environmental transport pathways--atmospheric, surface water, and ground water--and projects and appropriate modeling technique for each. The modeling sequence chosen for each pathway depends on the available data on doses, the degree of confidence justified by such existing data, and the level of sophistication deemed appropriate for the particular pathway and time period being considered

  7. The collaboratory approach

    International Nuclear Information System (INIS)

    A open-quotes collaboratoryclose quotes has been defined as a center without walls, in which researchers can perform their work without regard to geographical location. To an increasing degree, engineering design and development is also taking the form of far-flung collaborations among divisions of a plant, subcontractors, university consultants and customers. It has long been recognized that quality engineering education presents the student with an environment that duplicates as much as possible that which the graduate will encounter in industry. To that end, it is important that engineering schools begin to introduce the collaboratory approach in its preparation, and even use it in delivery of subject matter to students

  8. URBAN POLITICS: KEY APPROACHES

    Directory of Open Access Journals (Sweden)

    Ledyaeva Ol'ga Mikhaylovna

    2012-10-01

    Full Text Available Several approaches that underlie urban politics are discussed in the paper. They include neo-liberalism, political economy discourse, elitist/pluralist debates, and postmodernism. The neoliberal approach focuses on the limited role of the state and individual responsibility. The legal framework protects both the rights and responsibilities of individuals and regulates the operation of the market. It is the market that fosters individual choices and provides goods and services by virtue of the processes which are flexible, efficient and transparent. The political economy approaches (regulation theory, public choice theory, neo-Marxism explain urban politics via the analysis of national and international economic processes and changes in contemporary capitalism. Changes in national and international economies determine what solutions are possible. The discourse has been influenced by the debate on globalization of capital and labour markets. Modern elitism and neopluralism are represented by theories of "growth machines" and "urban regimes". The former focuses on bargaining alliances between political and business leaders in order to manage the urban system and to promote its growth. The latter develops neopluralist explanations of power within local communities with an emphasis on the fragmented nature of the government where local authorities lack comprehensive governing powers. Postmodernism views the city as the site of the crisis of late capitalism which leads to segregation of neighbourhoods onto prosperous areas and ghettoes. In contrast to the modern city, the postmodern city is not defined by its industrial base; rather, it is determined by its consumerist environment of malls and museums, characterized by revivalist architecture. At the same time, the suburban shopping mall and a motorway network make nonsense of the idea of the city as a unique and well-defined space. These and other approaches encompass a wide spectrum of possibilities in the study of urban and regional politics in relation to the Russian context. In the recent two decades, several studies of the power of urban and regional communities (A. Chirikova, N. Lapina, V. Gel'man, D. Seltser, D. Tev show that it can contribute for a better understanding of the Russian local politics and government.

  9. The collaboratory approach

    Energy Technology Data Exchange (ETDEWEB)

    Peskin, A.M.

    1997-04-01

    A {open_quotes}collaboratory{close_quotes} has been defined as a center without walls, in which researchers can perform their work without regard to geographical location. To an increasing degree, engineering design and development is also taking the form of far-flung collaborations among divisions of a plant, subcontractors, university consultants and customers. It has long been recognized that quality engineering education presents the student with an environment that duplicates as much as possible that which the graduate will encounter in industry. To that end, it is important that engineering schools begin to introduce the collaboratory approach in its preparation, and even use it in delivery of subject matter to students.

  10. The Capability Approach

    OpenAIRE

    Robeyns, I. A. M.

    2011-01-01

    In its most general description, the capability approach is a flexible and multi-purpose normative framework, rather than a precise theory of well-being, freedom or justice. At its core are two normative claims: first, the claim that the freedom to achieve well-being is of primary moral importance, and second, that freedom to achieve well-being is to be understood in terms of people’s capabilities, that is, their real opportunities to do and be what they have reason to value. This framework...

  11. Proteomics approaches to fibrotic disorders

    OpenAIRE

    Gucek, Marjan

    2012-01-01

    This review provides an introduction to mass spectrometry based proteomics and discusses several proteomics approaches that are relevant in understanding the pathophysiology of fibrotic disorders and the approaches that are frequently used in biomarker discovery.

  12. Anterior Approach Total Hip Replacement

    Medline Plus

    Full Text Available ... a hip replacement through the anterior supine intramuscular approach. “OR-Live,” the vision of improving health. Good ... to watch Dr. Keith Berend perform an anterior approach total hip replacement with the patient on a ...

  13. Approaches for Stereo Matching

    Directory of Open Access Journals (Sweden)

    Takouhi Ozanian

    1995-04-01

    Full Text Available This review focuses on the last decade's development of the computational stereopsis for recovering three-dimensional information. The main components of the stereo analysis are exposed: image acquisition and camera modeling, feature selection, feature matching and disparity interpretation. A brief survey is given of the well known feature selection approaches and the estimation parameters for this selection are mentioned. The difficulties in identifying correspondent locations in the two images are explained. Methods as to how effectively to constrain the search for correct solution of the correspondence problem are discussed, as are strategies for the whole matching process. Reasons for the occurrence of matching errors are considered. Some recently proposed approaches, employing new ideas in the modeling of stereo matching in terms of energy minimization, are described. Acknowledging the importance of computation time for real-time applications, special attention is paid to parallelism as a way to achieve the required level of performance. The development of trinocular stereo analysis as an alternative to the conventional binocular one, is described. Finally a classification based on the test images for verification of the stereo matching algorithms, is supplied.

  14. Endoscopic approach to achalasia

    Directory of Open Access Journals (Sweden)

    Michaela Müller

    2013-01-01

    Full Text Available Achalasia is a primary esophageal motor disorder. The etiology is still unknown and therefore all treatment options are strictly palliative with the intention to weaken the lower esophageal sphincter (LES. Current established endoscopic therapeutic options include pneumatic dilation (PD or botulinum toxin injection. Both treatment approaches have an excellent symptomatic short term effect, and lead to a reduction of LES pressure. However, the long term success of botulinum toxin (BT injection is poor with symptom recurrence in more than 50% of the patients after 12 mo and in nearly 100% of the patients after 24 mo, which commonly requires repeat injections. In contrast, after a single PD 40%-60% of the patients remain asymptomatic for ? 10 years. Repeated on demand PD might become necessary and long term remission can be achieved with this approach in up to 90% of these patients. The main positive predictors for a symptomatic response to PD are an age > 40 years, a LES-pressure reduction to 40 years, was nearly equivalent to surgery. A new promising technique might be peroral endoscopic myotomy, although long term results are needed and practicability as well as safety issues must be considered. Treatment with a temporary self expanding stent has been reported with favorable outcomes, but the data are all from one study group and must be confirmed by others before definite recommendations can be made. In addition to its use as a therapeutic tool, endoscopy also plays an important role in the diagnosis and surveillance of patients with achalasia.

  15. Proteomics - new analytical approaches

    International Nuclear Information System (INIS)

    Full text: Recent developments in the sequencing of the human genome have indicated that the number of coding gene sequences may be as few as 30,000. It is clear, however, that the complexity of the human species is dependent on the much greater diversity of the corresponding protein complement. Estimates of the diversity (discrete protein species) of the human proteome range from 200,000 to 300,000 at the lower end to 2,000,000 to 3,000,000 at the high end. In addition, proteomics (the study of the protein complement to the genome) has been subdivided into two main approaches. Global proteomics refers to a high throughput examination of the full protein set present in a cell under a given environmental condition. Focused proteomics refers to a more detailed study of a restricted set of proteins that are related to a specified biochemical pathway or subcellular structure. While many of the advances in proteomics will be based on the sequencing of the human genome, de novo characterization of protein microheterogeneity (glycosylation, phosphorylation and sulfation as well as the incorporation of lipid components) will be required in disease studies. To characterize these modifications it is necessary to digest the protein mixture with an enzyme to produce the corresponding mixture of peptides. In a process analogous to sequencing of the genome, shot-gun sequencing of the proteome is based on the characterization of the key fragments produced by such a digest. Thus, a gments produced by such a digest. Thus, a glycopeptide and hence a specific glycosylation motif will be identified by a unique mass and then a diagnostic MS/MS spectrum. Mass spectrometry will be the preferred detector in these applications because of the unparalleled information content provided by one or more dimensions of mass measurement. In addition, highly efficient separation processes are an absolute requirement for advanced proteomic studies. For example, a combination of the orthogonal approaches, HPLC and HPCE, can be very powerful for high resolution peptide mapping (hydrophobicity and ionic charge). This presentation will describe the development of new instrumentation based on the combination of capillary-based separation systems, including reversed phase and ion exchange HPLC integrated with on-line mass spectrometry. This approach can be used for stand-alone shot-gun sequencing or integrated with 2D-gel proteomic studies. Examples will include global studies such as the yeast proteome and focused studies on selected protein extracts such as secreted and nuclear proteins from mammalian cells

  16. Approach to team skills training

    International Nuclear Information System (INIS)

    The US commercial nuclear power industry has recognized the importance of team skills in control room operation. The desire to combine training of team interaction skills, like communications, with technical knowledge of reactor operations requires a unique approach to training. An NRC-sponsored study identified a five-phase approach to team skills training designed to be consistent with the systems approach to training currently endorsed by the NRC Policy Statement on Training and Qualification. This paper describes an approach to team skills training with emphasis on the nuclear power plant control room crew. An approach to team skills training

  17. Integration a functional approach

    CERN Document Server

    Bichteler, Klaus

    1998-01-01

    This book covers Lebesgue integration and its generalizations from Daniell's point of view, modified by the use of seminorms. Integrating functions rather than measuring sets is posited as the main purpose of measure theory. From this point of view Lebesgue's integral can be had as a rather straightforward, even simplistic, extension of Riemann's integral; and its aims, definitions, and procedures can be motivated at an elementary level. The notion of measurability, for example, is suggested by Littlewood's observations rather than being conveyed authoritatively through definitions of (sigma)-algebras and good-cut-conditions, the latter of which are hard to justify and thus appear mysterious, even nettlesome, to the beginner. The approach taken provides the additional benefit of cutting the labor in half. The use of seminorms, ubiquitous in modern analysis, speeds things up even further. The book is intended for the reader who has some experience with proofs, a beginning graduate student for example. It might...

  18. Coordinated Parallel Runway Approaches

    Science.gov (United States)

    Koczo, Steve

    1996-01-01

    The current air traffic environment in airport terminal areas experiences substantial delays when weather conditions deteriorate to Instrument Meteorological Conditions (IMC). Expected future increases in air traffic will put additional pressures on the National Airspace System (NAS) and will further compound the high costs associated with airport delays. To address this problem, NASA has embarked on a program to address Terminal Area Productivity (TAP). The goals of the TAP program are to provide increased efficiencies in air traffic during the approach, landing, and surface operations in low-visibility conditions. The ultimate goal is to achieve efficiencies of terminal area flight operations commensurate with Visual Meteorological Conditions (VMC) at current or improved levels of safety.

  19. Bioengineering a conceptual approach

    CERN Document Server

    Pavlovic, Mirjana

    2015-01-01

    This book explores critical principles and new concepts in bioengineering, integrating the biological, physical and chemical laws and principles that provide a foundation for the field. Both biological and engineering perspectives are included, with key topics such as the physical-chemical properties of cells, tissues and organs; principles of molecules; composition and interplay in physiological scenarios; and the complex physiological functions of heart, neuronal cells, muscle cells and tissues. Chapters evaluate the emerging fields of nanotechnology, drug delivery concepts, biomaterials, and regenerative therapy. The leading individuals and events are introduced along with their critical research. Bioengineering: A Conceptual Approach is a valuable resource for professionals or researchers interested in understanding the central elements of bioengineering. Advanced-level students in biomedical engineering and computer science will also find this book valuable as a secondary textbook or reference.

  20. Text Steganographic Approaches: A Comparison

    Directory of Open Access Journals (Sweden)

    Monika Agarwal

    2013-02-01

    Full Text Available This paper presents three novel approaches of text steganography. The first approach uses the theme ofmissing letter puzzle where each character of message is hidden by missing one or more letters in a wordof cover. The average Jaro score was found to be 0.95 indicating closer similarity between cover andstego file. The second approach hides a message in a wordlist where ASCII value of embedded characterdetermines length and starting letter of a word. The third approach conceals a message, withoutdegrading cover, by using start and end letter of words of the cover. For enhancing the security of secretmessage, the message is scrambled using one-time pad scheme before being concealed and cipher text isthen concealed in cover. We also present an empirical comparison of the proposed approaches with someof the popular text steganographic approaches and show that our approaches outperform the existingapproaches.

  1. Approaching attometer laser vibrometry

    International Nuclear Information System (INIS)

    The heterodyne two-beam interferometer has been proven to be the optimal solution for laser-Doppler vibrometry regarding accuracy and signal robustness. The theoretical resolution limit for a two-beam interferometer of laser class 3R (up to 5 mW visible measurement-light) is in the regime of a few femtometer per square-root Hertz and well suited to study vibrations in microstructures. However, some new applications of RF-MEM resonators, nanostructures, and surface-nano-defect detection require resolutions beyond that limit. The resolution depends only on the noise and the sensor sensitivity to specimen displacements. The noise is already defined in nowadays systems by the quantum nature of light for a properly designed optical sensor and more light would lead to an inacceptable influence like heating of a very tiny structure. Thus, noise can only be improved by squeezed-light techniques which require a negligible loss of measurement light which is impossible for almost all technical measurement tasks. Thus, improving the sensitivity is the only possible path which could make attometer laser vibrometry possible. Decreasing the measurement wavelength would increase the sensitivity but would also increase the photon shot noise. In this paper, we discuss an approach to increase the sensitivity by assembling an additional mirror between interferometer and specimen to form an optical cavity. A detailed theoretical analysis of this setup is presented and we derive the resolution limit, discuss the main contributions to the uncertainty budget, and show a first experiment proving the sensitivity amplification of our approach

  2. Approaching attometer laser vibrometry

    Science.gov (United States)

    Rembe, Christian; Kadner, Lisa; Giesen, Moritz

    2014-05-01

    The heterodyne two-beam interferometer has been proven to be the optimal solution for laser-Doppler vibrometry regarding accuracy and signal robustness. The theoretical resolution limit for a two-beam interferometer of laser class 3R (up to 5 mW visible measurement-light) is in the regime of a few femtometer per square-root Hertz and well suited to study vibrations in microstructures. However, some new applications of RF-MEM resonators, nanostructures, and surface-nano-defect detection require resolutions beyond that limit. The resolution depends only on the noise and the sensor sensitivity to specimen displacements. The noise is already defined in nowadays systems by the quantum nature of light for a properly designed optical sensor and more light would lead to an inacceptable influence like heating of a very tiny structure. Thus, noise can only be improved by squeezed-light techniques which require a negligible loss of measurement light which is impossible for almost all technical measurement tasks. Thus, improving the sensitivity is the only possible path which could make attometer laser vibrometry possible. Decreasing the measurement wavelength would increase the sensitivity but would also increase the photon shot noise. In this paper, we discuss an approach to increase the sensitivity by assembling an additional mirror between interferometer and specimen to form an optical cavity. A detailed theoretical analysis of this setup is presented and we derive the resolution limit, discuss the main contributions to the uncertainty budget, and show a first experiment proving the sensitivity amplification of our approach.

  3. Approaching attometer laser vibrometry

    Energy Technology Data Exchange (ETDEWEB)

    Rembe, Christian; Kadner, Lisa; Giesen, Moritz [Research and Development, Polytec GmbH, Polytec Platz 1-7, 76337 Waldbronn (Germany)

    2014-05-27

    The heterodyne two-beam interferometer has been proven to be the optimal solution for laser-Doppler vibrometry regarding accuracy and signal robustness. The theoretical resolution limit for a two-beam interferometer of laser class 3R (up to 5 mW visible measurement-light) is in the regime of a few femtometer per square-root Hertz and well suited to study vibrations in microstructures. However, some new applications of RF-MEM resonators, nanostructures, and surface-nano-defect detection require resolutions beyond that limit. The resolution depends only on the noise and the sensor sensitivity to specimen displacements. The noise is already defined in nowadays systems by the quantum nature of light for a properly designed optical sensor and more light would lead to an inacceptable influence like heating of a very tiny structure. Thus, noise can only be improved by squeezed-light techniques which require a negligible loss of measurement light which is impossible for almost all technical measurement tasks. Thus, improving the sensitivity is the only possible path which could make attometer laser vibrometry possible. Decreasing the measurement wavelength would increase the sensitivity but would also increase the photon shot noise. In this paper, we discuss an approach to increase the sensitivity by assembling an additional mirror between interferometer and specimen to form an optical cavity. A detailed theoretical analysis of this setup is presented and we derive the resolution limit, discuss the main contributions to the uncertainty budget, and show a first experiment proving the sensitivity amplification of our approach.

  4. The Challenges of Becoming Agile : Implementing and Conducting Scrum in Integrated Product Development

    OpenAIRE

    Ovesen, Nis

    2012-01-01

    “In today's fast-paced, fiercely competitive world of commercial new product development, speed and flexibility are essential. Companies are increasingly realizing that the old, sequential approach to developing new products simply won't get the job done.” (Takeuchi & Nonaka, 1986) Now twenty-five years old, the statement from the 1986-edition of Harvard Business Review seems more true than ever before. Commercial markets are moving faster and faster, and time as a strategic source of com...

  5. APPROACH TO ORGANIC ACIDEMIA

    Directory of Open Access Journals (Sweden)

    Gholamreza ZAMANI

    2012-03-01

    Full Text Available Organic acidemias, also known as organic acidurias, are a group of disorders characterized by increased excretion of organic acids in urine. They result primarily from deficiencies of specific enzymes in the breakdown pathways of amino acids or from enzyme deficiencies in beta oxidation of fatty acids or carbohydrate metabolism. Organic acids also are found in the urine of some patients with mitochondrial disease.Most organic acidemias become clinically apparent during the newborn period or early infancy. After an initial period of well-being, affected children develop a life-threatening episode of metabolic acidosis characterized by an increased anion gap. This presenting episode may be mistaken for sepsis, and if unrecognized, is associated with significant mortality.Children with an organic acidemia are susceptible to metabolic decompensation during episodes of increased catabolism, such as intercurrent illness, trauma, or surgery. Parents and clinicians must be well informed about the initial signs of decompensation and trained in applying an emergency regimen . Surgeons and anesthesiologists should be aware of potential complications and their prevention during anesthesia and surgery.Diagnosis has been facilitated through the use of gas chromatograph-mass spectrometry (GC-MS and tandem mass spectrometry .Prenatal diagnosis is available for most disorders by detection of diagnostic compounds in amniotic fluid; by analysis of enzyme activities in amniocytes or chorionic villi; by molecular analysis; or by a combination of the three . Diagnosis also may be made through newborn screening by tandem mass spectrometry .Laboratory findings are an essential part of the diagnostic approach to organic acidemias. In most organic acidemias, metabolism of glucose, ketone bodies, and ammonia is deranged primarily or secondarily, in addition to derangement of the acid-base balance. Hypoglycemia, lactic and/or ketoacidosis, and hyperammonemia of varying severity accompany the overt or compensated acidosis. In most instances, a definite diagnosis will be achieved by gas chromatography/mass spectrometry (GC/MS studies of the urine.However sometimes definite diagnosis by clinical and laboratory assessments is not conclusive, in this cae diagnostic approach must be supported by loading tests. The majority of organic acidemias may be treated by limiting the source of intake or removing the toxic intermediary metabolite. In the case of disorders lacking an effective treatment, an early diagnosis could lead to proper genetic counseling of the parents and to the option of reliable prenatal diagnosis of future pregnancies.

  6. COMPRENDO : Focus and approach

    DEFF Research Database (Denmark)

    Schulte-Oehlmann, U.; Albanis, T.

    2006-01-01

    Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife. Given the complexity of endocrine systems, there are many ways in which endocrine-disrupting chemicals (EDCs) can affect the body’s signaling system, and this makes unraveling the mechanisms of action of these chemicals difficult. A major concern is that some of these EDCs appear to be biologically active at extremely low concentrations. There is growing evidence to indicate that the guiding principle of traditional toxicology that “the dose makes the poison” may not always be the case because some EDCs do not induce the classical dose–response relationships. The European Union project COMPRENDO (Comparative Research on Endocrine Disrupters—Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds) therefore aims to develop an understanding of potential health problems posed by androgenic and antiandrogenic compounds (AACs) to wildlife and humans by focusing on the commonalities and differences in responses to AACs across the animal kingdom (from invertebrates to vertebrates).

  7. Aquatic environmental remediation approaches

    International Nuclear Information System (INIS)

    The 2011 Fukushima Daiichi Nuclear Plant's nuclear accident contaminated a significant portion of Fukushima Prefecture, and environmental remediation activities have been performed. To reduce the human exposure to the radiation induced by the nuclear contamination, one can reduce the radiation level in the environment, and/or eliminate radionuclide pathways to humans. This paper presents some case studies that are relevant to the Fukushima case. These examples include the Chernobyl nuclear accident's environmental and remediation assessments, U.S. Hanford environmental remediation activities, and the pesticide remediation assessment for the James River Estuary, Virginia, U.S.A. 1-D TODAM, 2-D FETRA and 3-D FLESCOT codes have been applied to the surface waters. TODAM code is currently being applied to the Ukedo and Takase rivers in Fukushima to predict cesium-137 migration in these rivers. A lesson learned from these experiences is that to achieve the effective clean-up, remediation decision makers must include knowledgeable scientists and competent engineers, so that environmental remediation activities are based on a scientifically-valid approach for a given contaminated location. Local participation to the remediation decision making is critically important. (author)

  8. Hysterectomy – Which Approach?

    Directory of Open Access Journals (Sweden)

    V. Mahasani,

    2014-01-01

    Full Text Available Hysterectomy operation is frequently performed on women. In the era of minimal invasive surgery, the route of hysterectomy depends upon numerous clinical variables. The aim of this study was to evaluate & suggest the appropriate approach for hysterectomy. A total of 250 patients were included in the presents study; they were divided, into three categories: Category I included 50 patients of Pelvic Organ Prolapse (POP for Vaginal Hysterectomy (VH, Category II included 40 patients who underwent Non Descent Vaginal Hysterectomy (NDVH, Category III included 160 patients who had Total Abdominal Hysterectomy (TAH. Operative time, hemorrhage, wound infection, post- operative analgesia, febrile morbidity, hospital stay and recovery were recorded for each patient. Indications for hysterectomy were POP, abnormal uterine bleeding (AUB and fibroid uterus. The study period showed a gradual increase in number of NDVH. Perioperative blood loss, post operative pain score, hospital stay; cost was less in patients with VH/NDVH. Uncomplicated, fast and cost effective technique for removal of uterus remains VH & NDVH. Non Descent Vaginal Hysterectomy is gaining increased acceptability among patients being minimally invasive with no visible scar.

  9. Modeling prosody: Different approaches

    Science.gov (United States)

    Carmichael, Lesley M.

    2002-11-01

    Prosody pervades all aspects of a speech signal, both in terms of raw acoustic outcomes and linguistically meaningful units, from the phoneme to the discourse unit. It is carried in the suprasegmental features of fundamental frequency, loudness, and duration. Several models have been developed to account for the way prosody organizes speech, and they vary widely in terms of their theoretical assumptions, organizational primitives, actual procedures of application to speech, and intended use (e.g., to generate speech from text vs. to model the prosodic phonology of a language). In many cases, these models overtly contradict one another with regard to their fundamental premises or their identification of the perceptible objects of linguistic prosody. These competing models are directly compared. Each model is applied to the same speech samples. This parallel analysis allows for a critical inspection of each model and its efficacy in assessing the suprasegmental behavior of the speech. The analyses illustrate how different approaches are better equipped to account for different aspects of prosody. Viewing the models and their successes from an objective perspective allows for creative possibilities in terms of combining strengths from models which might otherwise be considered fundamentally incompatible.

  10. Halitosis: the multidisciplinary approach.

    Science.gov (United States)

    Bollen, Curd M L; Beikler, Thomas

    2012-06-01

    Halitosis, bad breath or oral malodour are all synonyms for the same pathology. Halitosis has a large social and economic impact. For the majority of patients suffering from bad breath, it causes embarrassment and affects their social communication and life. Moreover,halitosis can be indicative of underlying diseases. Only a limited number of scientific publications were presented in this field until 1995. Ever since, a large amount of research is published, often with lack of evidence. In general, intraoral conditions, like insufficient dental hygiene, periodontitis or tongue coating are considered to be the most important cause (85%) for halitosis. Therefore, dentists and periodontologists are the first-line professionals to be confronted with this problem. They should be well aware of the origin, the detection and especially of the treatment of this pathology. In addition, ear-nose-throat-associated (10%) or gastrointestinal/endocrinological (5%) disorders may contribute to the problem. In the case of halitophobia, psychiatrical or psychological problems may be present. Bad breath needs a multidisciplinary team approach: dentists, periodontologists, specialists in family medicine, ear-nose-throat surgeons, internal medicine and psychiatry need to be updated in this field, which still is surrounded by a large taboo.Multidisciplinary bad breath clinics offer the best environment to examine and treat this pathology that affects around 25% of the whole population. This article describes the origin, detection and treatment of halitosis, regarded from the different etiological origins. PMID:22722640

  11. New approaches to COPD

    Directory of Open Access Journals (Sweden)

    P. J. Barnes

    2005-09-01

    Full Text Available No currently available treatments reduce the progression or suppress the inflammation of chronic obstructive pulmonary disease (COPD. However, with a better understanding of the inflammatory and destructive process, several targets have been identified, and new treatments are now in clinical development. Several specific therapies are directed against the influx of inflammatory cells into the airways and lung parenchyma that occurs in COPD, including adhesion molecule and chemokine-directed therapy, as well as therapies to inhibit tumour necrosis factor-alpha. Broad spectrum anti-inflammatory drugs are also in development, and include inhibitors of phosphodiesterase-4, p38 mitogen-activated protein kinase, nuclear factor-kappaB and phosphoinositide-3 kinase-gamma. More specific approaches include antioxidants, inhibitors of inducible nitric oxide synthase, and leukotriene B4 receptor antagonists. Inhibitors of epidermal growth factor receptor kinase and calcium-activated chloride channel inhibitors have the potential to inhibit mucus hypersecretion. Other therapies are targeted at the structural changes of COPD. Therapy to inhibit fibrosis is being developed against transforming growth factor-beta1 and protease activated receptor-2. There is also a search for serine proteinase and matrix metalloproteinase inhibitors to prevent lung destruction and the development of emphysema, as well as drugs such as retinoids that may even reverse this process. There is the need for validated biomarkers and monitoring techniques in early clinical studies with new therapies for chronic obstructive pulmonary disease.

  12. COMPRENDO: Focus and approach.

    Science.gov (United States)

    Schulte-Oehlmann, Ulrike; Albanis, Triantafyllos; Allera, Axel; Bachmann, Jean; Berntsson, Pia; Beresford, Nicola; Carnevali, Daniela Candia; Ciceri, Francesca; Dagnac, Thierry; Falandysz, Jerzy; Galassi, Silvana; Hala, David; Janer, Gemma; Jeannot, Roger; Jobling, Susan; King, Isabella; Klingmüller, Dietrich; Kloas, Werner; Kusk, Kresten Ole; Levada, Ramon; Lo, Susan; Lutz, Ilka; Oehlmann, Jörg; Oredsson, Stina; Porte, Cinta; Rand-Weaver, Marian; Sakkas, Vasilis; Sugni, Michela; Tyler, Charles; van Aerle, Ronny; van Ballegoy, Christoph; Wollenberger, Leah

    2006-04-01

    Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife. Given the complexity of endocrine systems, there are many ways in which endocrine-disrupting chemicals (EDCs) can affect the body's signaling system, and this makes unraveling the mechanisms of action of these chemicals difficult. A major concern is that some of these EDCs appear to be biologically active at extremely low concentrations. There is growing evidence to indicate that the guiding principle of traditional toxicology that "the dose makes the poison" may not always be the case because some EDCs do not induce the classical dose-response relationships. The European Union project COMPRENDO (Comparative Research on Endocrine Disrupters--Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds) therefore aims to develop an understanding of potential health problems posed by androgenic and antiandrogenic compounds (AACs) to wildlife and humans by focusing on the commonalities and differences in responses to AACs across the animal kingdom (from invertebrates to vertebrates) . PMID:16818253

  13. Energy Efficient Approaches: Altruist Energy Efficient Approach is the Best

    Directory of Open Access Journals (Sweden)

    B. Sunil Kumar#1, P. SivaChandrika*2, A. Shiva Kumar*3, K. Srinivasulu*4, Y. Rama Krishna

    2013-04-01

    Full Text Available This paper presents the energy efficient approaches and the importance of Altruistic approach in the absence of nearest neighboring nodes to the receiver. Two energy-efficient approaches have been proposed one is in-situ energy efficient approach, and the other is altruistic energy efficient approach. In the first approach existing nodes in network are only used and in second approach additional nodes called altruists are used. Generally comparison is done with five protocols with respect to these approaches and identifies altruistic DISH to be the right choice since it conserves 40-80 percent of energy, maintains the throughput advantage, and the cost efficiency compared to protocols without this approach is two times more. Our study also shows that an in-situ energy efficient approach is suitable only in certain confined scenarios. When transmit-receive pair wishes to initiate communication, neighboring nodes share their knowledge of channel usage. This helps to considerably reduce collisions and increases throughput significantly. However, it comes at the cost of increased energy consumption since idle nodes have to stay awake to overhear and acquire channel usage information. In fact this can be as high as 264% of a power-saving protocol without cooperation. The core idea is to introduce specialized nodes called altruists in the network whose only role is to acquire and share channel usage information. All other nodes, termed peers, go in to the sleep mode when idle due to this power consumption will be less. This altruistic approach seems to be complicated because it needs additional nodes to be deployed.

  14. Exploring Innovation - A language approach

    DEFF Research Database (Denmark)

    Mabogunje, Ade; Hansen, Poul H. Kyvsgård

    2014-01-01

    ” Innovation Management is a complex task that requires improved methods to support the exploration of multiple innovation dimensions. We suggest firms to adopt a language inspired approach in order to improve existing methods. The language approach is supported by a graphical innovation profile that maps the innovation features and choices. The paper demonstrates the applications and perspectives of this approach with reference to a qualitative case study.”

  15. Exploring Innovation – A Language Approach

    DEFF Research Database (Denmark)

    Mabogunje, Ade; Hansen, Poul H. Kyvsgård

    2013-01-01

    Innovation Management is a complex task that requires improved methods to support the exploration of multiple innovation dimensions. We suggest firms to adopt a language inspired approach in order to improve existing methods. The language approach is supported by a graphical innovation profile that maps the innovation features and choices. The paper demonstrates the applications and perspectives of this approach with reference to a qualitative case study.

  16. New approaches to knowledge acquisition

    CERN Document Server

    Lu, R-Q

    1994-01-01

    It is well recognized that knowledge acquisition is the critical bottleneck of knowledge engineering. This book presents three major approaches of current research in this field, namely the psychological approach, the artificial intelligence approach and the software engineering approach. Special attention is paid to the most recent advances in knowledge acquisition research, especially those made by Chinese computer scientists. A special chapter is devoted to its applications in other fields, e.g. language analysis, software engineering, computer-aided instruction, etc., which were done in Ch

  17. New Approaches to Final Cooling

    CERN Document Server

    Neuffer, David

    2015-01-01

    A high-energy muon collider scenario requires a "final cooling" system that reduces transverse emittance by a factor of ~10 while allowing longitudinal emittance increase. The baseline approach has low-energy transverse cooling within high-field solenoids, with strong longitudinal heating. This approach and its recent simulation are discussed. Alternative approaches which more explicitly include emittance exchange are also presented. Round-to-flat beam transform, transverse slicing, and longitudinal bunch coalescence are possible components of the alternative approach. A more explicit understanding of solenoidal cooling beam dynamics is introduced.

  18. Radiolab - three different approaches

    Directory of Open Access Journals (Sweden)

    Ola Stockfelt

    2012-04-01

    Full Text Available The three papers in this ‘suite’ have a special background and context. At the 2010 conference SoundActs in Aarhus the three panellists were each given the task to provide a paper with an analysis of the same sound object, thus exhibiting and contrasting different scholarly approaches to sound studies. The object was selected by Torben Sangild, who was familiar with the chosen context: the signature of the US radio programme and podcast Radiolab. The two other participants did not know the context and chose to analyse the sound object without further contextual investigation. This object was chosen for several reasons. First of all, it is brief (less than 17 seconds, which meant that it was possible to make a detailed analysis; at the same time, though, it is relatively complex, which means that it can accommodate three different analyses. It is a sound object with a global audience, taken from one of the most popular podcasts worldwide, accessible on the internet. Finally, it is a piece of functional sound design, rather than a work of art, which raises the question of context more clearly. The result is three rather different approaches: 1 a process analysis, observing analytical listening strategies towards the constructed object, 2 a vocal analysis, regarding the sound object as a polyphony of voices, and 3 a contextual analysis, framing the sound object as a radio signature. Ola Stockfelt analyses the sound object as something that is constructed via his own repeated listening process – as a scholarly-analytical analysis of the subjective act of creating meaning. He draws on presumptions and prejudices, demonstrating the impossibility of a purely structural listening. The analysis relates these hermeneutical reflections to formal musicological observations of harmony, timbre, space and rhythm in some detail. Ansa Lønstrup’s paper analyses the sound object as a polyphony of voices. Her analysis is inspired by two phenomenologists: Don Ihde, whose notion of ‘voice’ is understood in a more general sense as the voices of all things, and Lawrence Ferrara, who methodologically operates within tree levels of investigation: 1 the syntax, 2 the semantic and 3 the ontology level. Accordingly, this analysis is conducted, as if the sound object was performed by a vocal ensemble oscillating ‘between a musical and a speech act’. Torben Sangild’s paper focuses on the concrete function of the sound object as a radio signature. This prompts a generic analysis and a semantic model of radio signatures in general, eclectically employing formal, indexical, gestural, discursive and contextual levels of meaning. The analysis of the Radiolab signature focuses on the overall gesture of tension and release as well as the semantic elements in a constellation with the content and style of the radio programme. After the three individual contributions, a brief summary and conclusion will follow, answering any questions that may arise in the process.

  19. Morgagni hernia - laparoscopic approach

    Directory of Open Access Journals (Sweden)

    ?t.O. Georgescu

    2013-09-01

    Full Text Available INTRODUCTION: Morgagni hernia is due to a diaphragmatic defect, retrosternal congenital hernia being a rare form of hernie. The diagnosis is usually in childhood but there are cases that are found in adult or as a intraoperative surprise. The condition is asymptomatic or has nonspecific clinical manifestations or clinical dressing of often occlusive complications. The diagnosis is established by Rx thoracic imaging, barium enema or computed tomography (CT eso-gastro-duodenal passage. Treatment consists of reducing the hernia with or without dissection and resection of the hernia sac and diaphragmatic defect closure by suture the fascia endotoracica retrosternal and retrocostala or rectus abdominis sheath or plastic bag. CASE PRESENTATION: We present a case of a 49 years old woman admitted in our department for an insidious onset, several months ago, with postprandial upper abdominal pain, flatulence and nausea. CT scan revealed a mass of 95 / 130 / 80 mm, narrowly defined with homogeneous structure and negative densities (fat in the lower and middle mediastinum, outlining opacity described in cardiofrenic sinus radiography. The aspect was characteristic for a Morgagni hiatus hernia. Exploratory laparoscopy was performed using a 30º laparoscope inserted through a 10 mm supraombilical trocar; it revealed the parietal defect (Morgagni hernia and the herniation of greater omentum. Two additional 5 mm trocars are then inserted; the escaped great omentum was reintegrated and the parietal defect was laparoscopically sutured. To note, the peritoneal hernia sac was abandoned. Postoperative course was uneventful. A review of the literature data was also performed. CONCLUSION: Minimally invasive surgery is feasible, safe and tends to become “gold standard” therapeutic approach for the treatment of Morgagni hernia.

  20. Systems Approach to Environmental Pollution.

    Science.gov (United States)

    Chacko, George K., Ed.

    The objective of a two-day Symposium on Systems Approach to Environmental Pollution of the Operations Research Society of America at the 137th Annual Meeting of the American Association for the Advancement of Science, December 27-28, 1970 in Chicago, Illinois, was not to raise the litany of a systems approach as the answer to all environmental…

  1. Cancer and Complementary Health Approaches

    Science.gov (United States)

    ... health product or practice has been proven to cure cancer. Some complementary approaches may help people manage cancer ... section discusses complementary health approaches to directly treat cancer (that is, to try to cure the disease or cause a remission). No complementary ...

  2. Extending cosmology: the metric approach

    OpenAIRE

    Mendoza, S

    2012-01-01

    Comment: 2012, Extending Cosmology: The Metric Approach, Open Questions in Cosmology; Review article for an Intech "Open questions in cosmology" book chapter (19 pages, 3 figures). Available from: http://www.intechopen.com/books/open-questions-in-cosmology/extending-cosmology-the-metric-approach

  3. Artificial intelligence approaches in statistics

    International Nuclear Information System (INIS)

    The role of pattern recognition and knowledge representation methods from Artificial Intelligence within statistics is considered. Two areas of potential use are identified and one, data exploration, is used to illustrate the possibilities. A method is presented to identify and separate overlapping groups within cluster analysis, using an AI approach. The potential of such ''intelligent'' approaches is stressed

  4. Material Modelling - Composite Approach

    DEFF Research Database (Denmark)

    Nielsen, Lauge Fuglsang

    1997-01-01

    This report is part of a research project on "Control of Early Age Cracking" - which, in turn, is part of the major research programme, "High Performance Concrete - The Contractor's Technology (HETEK)", coordinated by the Danish Road Directorate, Copenhagen, Denmark, 1997.A composite-rheological model of concrete is presented by which consistent predictions of creep, relaxation, and internal stresses can be made from known concrete composition, age at loading, and climatic conditions. No other existing "creep prediction method" offers these possibilities in one approach.The model is successfully justified comparing predicted results with experimental data obtained in the HETEK-project on creep, relaxation, and shrinkage of very young concretes cured at a temperature of T = 20^o C and a relative humidity of RH = 100%. The model is also justified comparing predicted creep, shrinkage, and internal stresses caused by drying shrinkage with experimental results reported in the literature on the mechanical behavior of mature concretes. It is then concluded that the model presented applied in general with respect to age at loading.From a stress analysis point of view the most important finding in this report is that cement paste and concrete behave practically as linear-viscoelastic materials from an age of approximately 10 hours. This is a significant age extension relative to earlier studies in the literature where linear-viscoelastic behavior is only demonstrated from ages of a few days. Thus, linear-viscoelastic analysis methods are justified from the age of approximately 10 hours.The rheological properties of plain cement paste are determined. These properties are the principal material properties needed in any stress analysis of concrete. Shrinkage (autogeneous or drying) of mortar and concrete and associated internal stress states are examples of analysis made in this report. In this context is discussed that concrete strength is not an invariable material property. It is a property the potentials of which is highly and negatively influenced by any damage caused by stress concentrations such as introduced by eigenstrain/stress actions like shrinkage, temperature, and alkali-aggregate reactions.Based on the overall positive results reported it is suggested that creep functions needed in Finite Element Analysis (FEM-analysis) of structures can be established from computer-simulated experiments based on the model presented - calibrated by only a few real experiments.

  5. Vanpooling: the three major approaches

    Energy Technology Data Exchange (ETDEWEB)

    Sears, P.M.

    1979-08-01

    The manual provides technical assistance to existing or prospective vanpool sponsors. It is designed to help them promote vanpooling in its three major approaches: employer sponsored, third party sponsored, and driver owned and operated. The first chapter is an overview of vanpooling and a second chapter, on vanpool marketing, is addressed to ridesharing coordinators and others whose responsibilities include the promotion of vanpooling. Some fact sheets on the three approaches provide convenient summaries of the needs and opportunities of each approach and suggest solutions to practical problems likely to be encountered in starting new vanpool programs.

  6. A Biosemiotic Approach to Health

    DEFF Research Database (Denmark)

    Hoffmeyer, Jesper

    2010-01-01

    By replacing the traditional chemical approach to the understanding of body function by a sign-theoretic or semiotic approach, biosemiotics enters a no-man’s-land between biological and social domains of human life. The aim is not to subsume the social under the biological or vice versa; both approaches are invaluable. The aim is to find a common platform that serves in treating human persons as undivided wholes. Since semiosis (viz. the meaningful interpretation of cues, signals, events or states) is vital to communication at both levels, the resulting sign-process is a viable choice as the basis for an integrated theory of health.

  7. Approaches to Scandinavian Crime Fiction

    DEFF Research Database (Denmark)

    Agger, Gunhild

    2010-01-01

    The working paper discusses some of the major approaches to Scandinavian crime fiction in the light of the dominant features of crime culture, e.g. the broad exposure of crime fiction via different platforms and media. In this connection, the concept of mediatization is considered as well as the approach of genre typology and the concept of evil – seemingly disparate concepts and approaches, but all related to the complex processes in the borderlands between crime fiction and society. Using examples from Scandinavian crime fiction, I discuss whether the growing proximity to international genres, ways of production and standards increasingly removes Scandinavian crime fiction from its original attractions or not.

  8. Chain approach, innovation and leadership

    Directory of Open Access Journals (Sweden)

    R.V. De Mulder

    2011-02-01

    Full Text Available This article is available in English and Dutch This contribution deals with a new paradigm of performance, how it promotes innovation and is consistent with the chain approach developed by Jan Grijpink and his research team. The new paradigm of performance will be explained and the parallels with the chain approach will be discussed. The background of both approaches is the frequent failure of the prevailing views, on the one hand, and the importance of innovative intervention in the difficult and often chaotic reality, on the other.

  9. Paying for Complementary Health Approaches

    Science.gov (United States)

    ... care spending but 11.2 percent of total out-of-pocket health care spending in the United States. Top Paying for Complementary Health Approaches Out-of-Pocket People often pay for complementary health services and ...

  10. Anterior Approach Total Hip Replacement

    Medline Plus

    Full Text Available ... renewed interest at this time due to several advantages that it brings. The approach that is performed ... metal more frequently because I feel that the advantage to the patient of that large head is ...

  11. Anterior Approach Total Hip Replacement

    Medline Plus

    Full Text Available ... an anterior approach total hip replacement with the patient on a regular OR table supine. My name ... less invasive without being small incision surgery. Obese patients can be easier due to less distribution of ...

  12. Anterior Approach Total Hip Replacement

    Medline Plus

    Full Text Available ... can certainly get through this approach with no problem, but it’s more challenging. This would be an ... are patients that really can present very big problems, and the next choice is the heavy male ...

  13. Simplified Approach to Inspection Planning

    DEFF Research Database (Denmark)

    Bloch, Allan; SØrensen, John Dalsgaard

    2000-01-01

    A simplified and practically applicable approach for risk based inspection planning of fatigue sensitive structural details is presented. The basic idea behind the approach is that the fatigue sensitive details are categorized according to their stress intensity factors and their design fatigue life to service life ratio, i.e. the fatigue design factor (FDF) and SN curve. When the reserve strength ratio (RSR) and the corresponding probability of total structural failure given fatigue failure of the considered detail is known it is possible to make a generic description of fatigue sensitive structural details and thereby develop pre-made inspection plans in tables which depend on relative cost of inspections, repairs and failures. Due to the simplicity of the format of the developed inspection plans the proposed approach has a high potential in code making for the design and maintenance of steel structures. The validity of the proposed approach is illustrated through a study regarding inspection planning of offshore structures.

  14. A Collaborative Approach to Supervision.

    Science.gov (United States)

    Burke, Peter J.; Fessler, Ralph

    1983-01-01

    Explores key components of the teacher professional growth process and examines how "significant others" can contribute to the components discussed. Presents a structure for a collaborative approach to supervision and staff development. (FL)

  15. Complex approach in arils study

    OpenAIRE

    Trusov, Nikolay A.

    2013-01-01

    Arils are found in numerous Angiosperm taxa. The complex approach (morphologo-anatomical and biochemical researches) in studying of aril-having fruits is recommended. The arils origin hypothesis is offered. Some functions of arils are showed.

  16. Nonlinear Approaches in Engineering Applications

    CERN Document Server

    Jazar, Reza

    2012-01-01

    Nonlinear Approaches in Engineering Applications focuses on nonlinear phenomena that are common in the engineering field. The nonlinear approaches described in this book provide a sound theoretical base and practical tools to design and analyze engineering systems with high efficiency and accuracy and with less energy and downtime. Presented here are nonlinear approaches in areas such as dynamic systems, optimal control and approaches in nonlinear dynamics and acoustics. Coverage encompasses a wide range of applications and fields including mathematical modeling and nonlinear behavior as applied to microresonators, nanotechnologies, nonlinear behavior in soil erosion,nonlinear population dynamics, and optimization in reducing vibration and noise as well as vibration in triple-walled carbon nanotubes. This book also: Provides a complete introduction to nonlinear behavior of systems and the advantages of nonlinearity as a tool for solving engineering problems Includes applications and examples drawn from the el...

  17. Cell approach to glass transition

    International Nuclear Information System (INIS)

    We present a novel theoretical approach to understanding the complex dynamics of glass-forming liquids, granular packings and amorphous solids. This theory, which is an elaboration of the free volume and inherent structure approaches, allows one to retrieve the thermodynamical properties of these systems from studies of geometrical and topological properties of local, static configurations alone. When applied to hard-sphere systems, the present theory reproduces with a good quantitative agreement the equation of state for the crystalline and the disordered glassy phases. Moreover, we find that, as the density approaches a critical value close to the random close-packing density, the configurational entropy approaches zero and the large relaxation time diverges according to the Vogel-Fulcher behaviour, following also the Adam-Gibbs relation

  18. Anterior Approach Total Hip Replacement

    Medline Plus

    Full Text Available ... Dr. Eric Dewitt, from Belgium, who helped me learn this surgical approach. This is a previously described ... capsule. Okay. What do you think on the learning curve? 4 No, I think that’s good. I ...

  19. Anterior Approach Total Hip Replacement

    Medline Plus

    Full Text Available ... the anterior supine intramuscular approach. “OR-Live,” the vision of improving health. Good evening and welcome to ... should know that this is done under direct vision. Yeah. You are seeing everything you’re doing. ...

  20. Abstract Cauchy problems three approaches

    CERN Document Server

    Melnikova, Irina V

    2001-01-01

    Although the theory of well-posed Cauchy problems is reasonably understood, ill-posed problems-involved in a numerous mathematical models in physics, engineering, and finance- can be approached in a variety of ways. Historically, there have been three major strategies for dealing with such problems: semigroup, abstract distribution, and regularization methods. Semigroup and distribution methods restore well-posedness, in a modern weak sense. Regularization methods provide approximate solutions to ill-posed problems. Although these approaches were extensively developed over the last decades by many researchers, nowhere could one find a comprehensive treatment of all three approaches.Abstract Cauchy Problems: Three Approaches provides an innovative, self-contained account of these methods and, furthermore, demonstrates and studies some of the profound connections between them. The authors discuss the application of different methods not only to the Cauchy problem that is not well-posed in the classical sense, b...

  1. An Approach to Interface Synthesis

    DEFF Research Database (Denmark)

    Madsen, Jan; Hald, Bjarne

    1995-01-01

    Presents a novel interface synthesis approach based on a one-sided interface description. Whereas most other approaches consider interface synthesis as optimizing a channel to existing client/server modules, we consider the interface synthesis as part of the client/server module synthesis (which may contain the re-use of existing modules). The interface synthesis approach describes the basic transformations needed to transform the server interface description into an interface description on the client side of the communication medium. The synthesis approach is illustrated through a point-to-point communication, but is applicable to synthesis of a multiple client/server environment. The interface description is based on a formalization of communication events.

  2. Anterior Approach Total Hip Replacement

    Medline Plus

    Full Text Available ... where in my hands same approach, same patient population, I have over a 15 percent risk of ... on. My experience, these patients have full leg control in about 24 hours. Yeah. They can get ...

  3. Theoretical Approaches to HERA Physics

    OpenAIRE

    Merino, C

    2002-01-01

    A review is presented of the different theoretical models proposed to approach consistently the interplay between soft and hard physics, that can now be studied experimentally at HERA for the first time.

  4. Anterior approach for knee arthrography

    International Nuclear Information System (INIS)

    Objective. To develop a new method of magnetic resonance arthrography (MRA) of the knee using an anterior approach analogous to the portals used for knee arthroscopy.Design. An anterior approach to the knee joint was devised mimicking anterior portals used for knee arthroscopy. Seven patients scheduled for routine knee MRA were placed in a decubitus position and under fluoroscopic guidance a needle was advanced from a position adjacent to the patellar tendon into the knee joint. After confirmation of the needle tip location, a dilute gadolinium solution was injected.Results and conclusion. All the arthrograms were technically successful. The anterior approach to knee MRA has greater technical ease than the traditional approach with little patient discomfort. (orig.)

  5. Qualitative Approaches to Evaluating Education.

    Science.gov (United States)

    Fetterman, David M.

    1988-01-01

    Discusses qualitative research and its application to educational evaluation. Approaches discussed include the following: (1) ethnography; (2) naturalistic inquiry; (3) generic pragmatic (sociological) inquiry; (4) connoisseurship/criticism; (5) metaphors; and (6) phenomenography. (FMW)

  6. Toxicological approaches to complex mixtures.

    OpenAIRE

    Mauderly, J L

    1993-01-01

    This paper reviews the role of toxicological studies in understanding the health effects of environmental exposures to mixtures. The approach taken is to review mixtures that have received the greatest emphasis from toxicology; major mixtures research programs; the toxicologist's view of mixtures and approaches to their study; and the complementary roles of toxicological, clinical, and epidemiological studies. Studies of tobacco smoke, engine exhaust, combustion products, and air pollutants c...

  7. Bounding approaches to system identification

    CERN Document Server

    Norton, John; Piet-Lahanier, Hélène; Walter, Éric

    1996-01-01

    In response to the growing interest in bounding error approaches, the editors of this volume offer the first collection of papers to describe advances in techniques and applications of bounding of the parameters, or state variables, of uncertain dynamical systems. Contributors explore the application of the bounding approach as an alternative to the probabilistic analysis of such systems, relating its importance to robust control-system design.

  8. The Database State Machine Approach

    OpenAIRE

    Pedone, Fernando; Guerraoui, Rachid; Schiper, Andre

    1999-01-01

    Database replication protocols have historically been built on top of distributed database systems, and have consequently been designed and implemented using distributed transactional mechanisms, such as atomic commitment. We present the Database State Machine approach, a new way to deal with database replication in a cluster of servers. This approach relies on a powerful atomic broadcast primitive to propagate transactions between database servers, and alleviates the need for atomic comm...

  9. Strategy making : the approach matters

    OpenAIRE

    Pretorius, Marius; Maritz, Rachel

    2011-01-01

    PURPOSE – More than ever, businesses need to get their strategy right. Part of achieving this is the approach to strategy making that is chosen. The purpose of this paper is to describe how strategy making happens on the continuum of deliberate practice versus emerging strategy. DESIGN/METHODOLOGY/APPROACH – Through in-depth interviews with “strategy informants” (CEO’s) in businesses and questionnaires to respondents (managers) in the same organizations, statistical techniques ...

  10. Fighting corruption – a philosophical approach

    OpenAIRE

    Vorster, Schalk W.

    2013-01-01

    Corruption has reached astounding proportions in South Africa. The purpose of this article is to contribute to philosophical approaches aimed at combating corruption. In considering punishment for acts of corruption the most common approach is based on the philosophical theory of consequentialism, which allows only consideration of the consequences of corrupt acts. Ideally, cognisance should be taken of the norms in question, especially those norms demanding the judicious execution of obligat...

  11. Three Approaches to High School Classroom Music.

    Science.gov (United States)

    O'Brien, Wanda

    1985-01-01

    Three process-oriented approaches to high school classroom music--the problem-solving approach, the aesthetic criticism approach, and the interrelated fine arts approach--are discussed. These three approaches are recommended for curriculum reform related to the national reports. (RM)

  12. 49 CFR 236.377 - Approach locking.

    Science.gov (United States)

    2010-10-01

    ... 2010-10-01 false Approach locking. 236.377 Section 236.377 Transportation Other Regulations Relating to Transportation...APPLIANCES Interlocking Inspection and Tests § 236.377 Approach locking. Approach locking shall...

  13. 33 CFR 167.202 - In the approaches to Chesapeake Bay: Eastern approach.

    Science.gov (United States)

    2010-07-01

    ...2010-07-01 2010-07-01 false In the approaches to Chesapeake Bay: Eastern approach. 167.202 Section 167.202 Navigation...Atlantic East Coast § 167.202 In the approaches to Chesapeake Bay: Eastern approach....

  14. City evacuations an interdisciplinary approach

    CERN Document Server

    Binner, Jane; Branicki, Layla; Galla, Tobias; Jones, Nick; King, James; Kolokitha, Magdalini; Smyrnakis, Michalis

    2015-01-01

    Evacuating a city is a complex problem that involves issues of governance, preparedness education, warning, information sharing, population dynamics, resilience and recovery. As natural and anthropogenic threats to cities grow, it is an increasingly pressing problem for policy makers and practitioners.   The book is the result of a unique interdisciplinary collaboration between researchers in the physical and social sciences to consider how an interdisciplinary approach can help plan for large scale evacuations.  It draws on perspectives from physics, mathematics, organisation theory, economics, sociology and education.  Importantly it goes beyond disciplinary boundaries and considers how interdisciplinary methods are necessary to approach a complex problem involving human actors and increasingly complex communications and transportation infrastructures.   Using real world case studies and modelling the book considers new approaches to evacuation dynamics.  It addresses questions of complexity, not only ...

  15. Solid mechanics a variational approach

    CERN Document Server

    Dym, Clive L

    2013-01-01

    Solid Mechanics: A Variational Approach, Augmented Edition presents a lucid and thoroughly developed approach to solid mechanics for students engaged in the study of elastic structures not seen in other texts currently on the market. This work offers a clear and carefully prepared exposition of variational techniques as they are applied to solid mechanics. Unlike other books in this field, Dym and Shames treat all the necessary theory needed for the study of solid mechanics and include extensive applications. Of particular note is the variational approach used in developing consistent structural theories and in obtaining exact and approximate solutions for many problems.  Based on both semester and year-long courses taught to undergraduate seniors and graduate students, this text is geared for programs in aeronautical, civil, and mechanical engineering, and in engineering science. The authors’ objective is two-fold: first, to introduce the student to the theory of structures (one- and two-dimensional) as ...

  16. A Reverse Approach to Superconductivity

    Directory of Open Access Journals (Sweden)

    Shuiquan Deng

    2013-06-01

    Full Text Available In contrast to the normal operator approach, our reverse approach starts from the state vector in the Hilbert space. In this work, we give a concise introduction to our recent work in this aspect. By postulating a superconducting state (SCS to be a generalized coherent state (GCS constructed by pure group theory, we show that some important properties such as the Cooper pairs of the SCS naturally appear in this new framework without resorting to the microscopic origin. This latter characteristic renders this theory a more universal feature in comparison with other theories developed by the operator approach. The studies on the residue of the pair-wise constraint due to the collapse of the GCS lead to a “flat/steep” band model for searching new superconductors.

  17. Systems Science Approach to Data

    Science.gov (United States)

    Kadirkamanathan, Visakan

    Behaviours of many complex systems of interest cannot be adequately described since the underlying science has not advanced enough to be able to tease out the mathematical relationships. There is a need therefore to use methods and tools that capture the structure in the data that is representative of the systems behaviour. The subject of system identification allows us to deduce mathematical relations that govern the dynamics of systems based on the observed data. In addition, it can also be used to understand the system from basic principles. In this brief talk, the main approaches of systems science to data are reviewed identifying their strengths and limitations. The approaches include computational intelligence methods such as neural networks, genetic algorithms and fuzzy logic, as well as system identification methods in both time and frequency domains. Examples from physical science, neuroscience and social science serve to highlight achievements of the systems science approach to data.

  18. Thermodynamic approach to biomass gasification

    International Nuclear Information System (INIS)

    The document presents an approach of biomass transformation in presence of steam, hydrogen or oxygen. Calculation results based on thermodynamic equilibrium are discussed. The objective of gasification techniques is to increase the gas content in CO and H2. The maximum content in these gases is obtained when thermodynamic equilibrium is approached. Any optimisation action of a process. will, thus, tend to approach thermodynamic equilibrium conditions. On the other hand, such calculations can be used to determine the conditions which lead to an increase in the production of CO and H2. An objective is also to determine transformation enthalpies that are an important input for process calculations. Various existing processes are assessed, and associated thermodynamic limitations are evidenced. (author)

  19. Systems biology approach to bioremediation

    Energy Technology Data Exchange (ETDEWEB)

    Chakraborty, R.; Wu, C. H.; Hazen, T. C.

    2012-01-01

    Bioremediation has historically been approached as a ?black box? in terms of our fundamental understanding. Thus it succeeds and fails, seldom without a complete understanding of why. Systems biology is an integrated research approach to study complex biological systems, by investigating interactions and networks at the molecular, cellular, community, and ecosystem level. The knowledge of these interactions within individual components is fundamental to understanding the dynamics of the ecosystem under investigation. Understanding and modeling functional microbial community structure and stress responses in environments at all levels have tremendous implications for our fundamental understanding of hydrobiogeochemical processes and the potential for making bioremediation breakthroughs and illuminating the ?black box?.

  20. [Surgical approaches for endometrial cancer? ].

    Science.gov (United States)

    Narducci, Fabrice; Jean-Laurent, Mehdi; Lambaudie, Eric; Coutty, Nadège; Leblanc, Eric

    2012-01-01

    The recommendations of the Institut national du cancer and of the Société francaise d'oncologie gynécologique in endometrial carcinoma (2010) reported that laparoscopy is the standard surgical approach for patients with apparent stage FIGO I in preoperative outcomes including MRI (www.e-cancer.fr). For patients with stage FIGO greater than I, laparotomy is the standard surgical approach. In case of lymph nodes or peritoneal restaging, the laparoscopy could be a good option especially by extraperitoneal route in patients with recent first surgery. PMID:22192868

  1. Elementary calculus an infinitesimal approach

    CERN Document Server

    Keisler, H Jerome

    2013-01-01

    This first-year calculus book is centered around the use of infinitesimals, an approach largely neglected until recently for reasons of mathematical rigor. It exposes students to the intuition that originally led to the calculus, simplifying their grasp of the central concepts of derivatives and integrals. The author also teaches the traditional approach, giving students the benefits of both methods.Chapters 1 through 4 employ infinitesimals to quickly develop the basic concepts of derivatives, continuity, and integrals. Chapter 5 introduces the traditional limit concept, using approximation p

  2. Real analysis a constructive approach

    CERN Document Server

    Bridger, Mark

    2012-01-01

    A unique approach to analysis that lets you apply mathematics across a range of subjects This innovative text sets forth a thoroughly rigorous modern account of the theoretical underpinnings of calculus: continuity, differentiability, and convergence. Using a constructive approach, every proof of every result is direct and ultimately computationally verifiable. In particular, existence is never established by showing that the assumption of non-existence leads to a contradiction. The ultimate consequence of this method is that it makes sense-not just to math majors but also to students from a

  3. Probabilistic approach to EMP assessment

    International Nuclear Information System (INIS)

    The development of nuclear EMP hardness requirements must account for uncertainties in the environment, in interaction and coupling, and in the susceptibility of subsystems and components. Typical uncertainties of the last two kinds are briefly summarized, and an assessment methodology is outlined, based on a probabilistic approach that encompasses the basic concepts of reliability. It is suggested that statements of survivability be made compatible with system reliability. Validation of the approach taken for simple antenna/circuit systems is performed with experiments and calculations that involve a Transient Electromagnetic Range, numerical antenna modeling, separate device failure data, and a failure analysis computer program

  4. International Approaches to Clinical Costing

    DEFF Research Database (Denmark)

    Chapman, Christopher; Kern, Anja

    2013-01-01

    This report has been commissioned by both HFMA and Monitor and the work has been led by Imperial College Business School’s Health Management Group. The report compares current approaches to costing, primarily across Europe. The findings reveal wide-ranging practices and uses for costing data, and provide opportunities for all healthsystems to learn and potentially improve their own approaches. The HFMA hopes to build on this initial baselining exercise to understand more about how key issues are being tackled in some of the health systems that have made the most progress with costing.

  5. A Freudian Approach to Education.

    Science.gov (United States)

    Gartner, Sandra L.

    This document offers the point of view that Bruno Bettelheim's writings, based on Sigmund Freud's approach to education, suggest the most practical applications for achieving positive results within the classroom. The overall result of a student being taught all through school by the Freudian method would be an extremely positive one. Such a…

  6. Budgeting Approaches in Community Colleges

    Science.gov (United States)

    Palmer, James C.

    2014-01-01

    Several budgeting approaches have been initiated as alternatives to the traditional, incremental process. These include formula budgeting; zero-base budgeting; planning, programming, and budgeting systems; and responsibility center budgeting. Each is premised on assumptions about how organizations might best make resource allocation decisions.…

  7. A Psychoanalytic Approach to Fieldwork

    Science.gov (United States)

    Ramvi, Ellen

    2012-01-01

    This article focuses on what both psychoanalysis and anthropology have in common: the emphasis on the researcher's own experience. An ethnographic fieldwork will be used to illustrate how a psychoanalytical approach unfolds the material when studying conditions for learning from experience among teachers in two Norwegian junior high schools, and…

  8. Anterior Approach Total Hip Replacement

    Medline Plus

    Full Text Available ... box. That’s right. Or in this case the computer. Yeah. Exactly. We’ll make some comments later ... and I have been doing all our liners changes through this approach. Exactly. That’s actually a good ...

  9. Anticoagulation management: a new approach.

    Science.gov (United States)

    Wurster, Mark; Doran, Trisha

    2006-08-01

    Anticoagulation therapy has been identified as an area in which new approaches to treatment and monitoring may allow for significant improvements in healthcare quality and costs. We evaluated the potential benefits of a new approach to anticoagulation therapy, utilizing decision support software, point-of-service testing, and workflow redesign. We performed an intervention study in the setting of a university-affiliated primary care clinic, involving 40 patients receiving chronic anticoagulation therapy. Study measurement included anticoagulation control, complications of therapy and related costs, as well as clinic revenue and overhead costs. After implementation of the new approach, the frequency of international normalized ratio (INR) results within therapeutic range increased from 34% to 67%. During a 1-year follow-up period, complications related to anticoagulation therapy were reduced by 91% (p revenue. For every dollar spent on clinic implementation and maintenance, over 25 US dollars was returned from cost containment and new revenue production. This approach allows a clinic to show improved anticoagulation control and complication rates while simultaneously improving financial performance. PMID:16893333

  10. Restaurant Sanitation: A New Approach

    Science.gov (United States)

    Hinckley, Walter J.

    1974-01-01

    The new approach taken by the New York City Health Department to the problems of surveillance and maintenance of high sanitation standards in food service establishments is explained. Results of a pilot study are presented followed by the new procedures and evaluation. Future plans are then indicated. (LS)

  11. Algorithmic approach to diagram techniques

    International Nuclear Information System (INIS)

    An algorithmic approach to diagram techniques of elementary particles is proposed. The definition and axiomatics of the theory of algorithms are presented, followed by the list of instructions of an algorithm formalizing the construction of graphs and the assignment of mathematical objects to them. (T.A.)

  12. A Backward Approach to Inquiry

    Science.gov (United States)

    Sher Hendrickson

    2006-01-01

    In the sciences, the National Science Education Standards further emphasize that learning science is an inquiry-based process; therefore, teaching methods should be inquiry-based. Use a backwards design approach to ensure that academic standards are met during student-centered, inquiry-based investigations for daily class activities, classroom discussions, and assessment of student understanding.

  13. Novel Approaches to Surfactant Administration

    OpenAIRE

    Donn, Steven M.; Samir Gupta

    2012-01-01

    Surfactant replacement therapy has been the mainstay of treatment for preterm infants with respiratory distress syndrome for more than twenty years. For the most part, surfactant is administered intratracheally, followed by mechanical ventilation. In recent years, the growing interest in noninvasive ventilation has led to novel approaches of administration. This paper will review these techniques and the associated clinical evidence.

  14. Innovative approach to staff management

    Directory of Open Access Journals (Sweden)

    Rodionova Elena Viktorovna

    2011-12-01

    Full Text Available This article reveals the essence of reproduction approach to the management staff that meets the requirements of an information type of production. A classification of the functions of personnel management, depending on the role of man in the workplace is given. Topical aspects of implementing the functions of personnel management in Russian enterprises are considered.

  15. A synthetic approach to abiogenesis.

    Science.gov (United States)

    Attwater, James; Holliger, Philipp

    2014-05-01

    Synthetic biology seeks to probe fundamental aspects of biological form and function by construction (resynthesis) rather than deconstruction (analysis). Here we discuss how such an approach could be applied to assemble synthetic quasibiological systems able to replicate and evolve, illuminating universal properties of life and the search for its origins. PMID:24781322

  16. Anterior Approach Total Hip Replacement

    Medline Plus

    Full Text Available ... this view, I mean this is the traditional Smith Meet Jeu De view of the acetabulum,. I ... re using only part of what’s called the “Smith-Peterson approach.” The true SmithPeterson, you would take ...

  17. Logicoalgebraic approach to symplectic mechanics

    International Nuclear Information System (INIS)

    A logicoalgebraic approach to symplectic mechanics is suggested, which exhibits the transition from the physical formulation (in terms of observables and states associated with a Boolean sigma-algebra) to the geometrical formulation (in terms of symplectic structures) of classical mechanics

  18. Teaching Ethics: A Direct Approach.

    Science.gov (United States)

    Penn, William Y., Jr.

    1990-01-01

    Compares five designs of an undergraduate ethics course at Saint Edward's University (Texas) in a 5-year study involving 318 students. Reveals the effectiveness of directly targeting and teaching in tandem the elements of moral reasoning. Bases study on Lawrence Kohlberg's moral development theory. Argues that this approach best develops moral…

  19. A Complexity Approach for Steganalysis

    CERN Document Server

    Bahi, Jacques M; Heam, Pierre-Cyrille

    2011-01-01

    In this proposal for the Journ\\`ees Codes et St\\'eganographie 2012, we define a new rigorous approach for steganalysis based on the complexity theory. It is similar to the definitions of security that can be found for hash functions, PRNG, and so on. We propose here a notion of \\emph{secure hiding} and we give a first secure hiding scheme.

  20. Hamiltonian approach to nonlinear oscillators

    International Nuclear Information System (INIS)

    A Hamiltonian approach to nonlinear oscillators is suggested. A conservative oscillator always admits a Hamiltonian invariant, H, which keeps unchanged during oscillation. This property is used to obtain approximate frequency-amplitude relationship of a nonlinear oscillator with acceptable accuracy. Two illustrating examples are given to elucidate the solution procedure.

  1. Hamiltonian approach to nonlinear oscillators

    Energy Technology Data Exchange (ETDEWEB)

    He Jihuan, E-mail: jhhe@dhu.edu.c [Modern Textile Institute, Donghua University, Shanghai 200051 (China)

    2010-05-10

    A Hamiltonian approach to nonlinear oscillators is suggested. A conservative oscillator always admits a Hamiltonian invariant, H, which keeps unchanged during oscillation. This property is used to obtain approximate frequency-amplitude relationship of a nonlinear oscillator with acceptable accuracy. Two illustrating examples are given to elucidate the solution procedure.

  2. Designing for Uncertainty: Three Approaches

    Science.gov (United States)

    Bennett, Scott

    2007-01-01

    Higher education wishes to get long life and good returns on its investment in learning spaces. Doing this has become difficult because rapid changes in information technology have created fundamental uncertainties about the future in which capital investments must deliver value. Three approaches to designing for this uncertainty are described…

  3. New approach to cosmological theory

    International Nuclear Information System (INIS)

    An approach to cosmological theory is described wherein time is measured in two ways, atomic time (t) used for atomic processes governed by quantum laws and mechanical time (tau) used with classical laws for the motion of bodies. These are related by tau = log t

  4. Nuclear regulation - the Canadian approach

    International Nuclear Information System (INIS)

    Although the Atomic Energy Control Board was established 35 years ago the basic philosophy of nuclear regulation in Canada and the underlying principles of the regulatory process remain essentially unchanged. This paper outlines the Canadian approach to nuclear regulation and explains in practical terms how the principles of regulation are applied. (author)

  5. Institutional repositories: two consortial approaches

    OpenAIRE

    Proudfoot, R.; Stockley, R.; Moyle, M.

    2006-01-01

    This poster illustrates two different consortial approaches to creating institutional repositories; the management structures of the White Rose consortium (the Universities of Leeds, Sheffield and York) and the SHERPA-LEAP (London E-prints Access Project) consortium are described. The presentation includes data on repository growth, access statistics and subject breakdown. Some areas for discussion when considering a consortial repository arrangement are suggested.

  6. Comparative Psychology: An Epigenetic Approach.

    Science.gov (United States)

    Greenberg, Gary

    1987-01-01

    A comparative psychology course oriented around the themes of phylogeny and ontogeny is described. The course emphasizes the evolution and development of behavioral processes and includes a discussion of the concept of integrative levels and Schneirla's approach/withdrawal theory. The course evaluates genetic determinism and stresses the principle…

  7. Covariant anomalies in cohomology approach

    International Nuclear Information System (INIS)

    We study a new cohomology approach to the covariant anomalies. As a general solution of a covariant condition, we obtain a set of differential forms from which the covariant (current and commutator) anomalies are derived algebraically. We also derive a generalized Bardeen-Zumino relation between the covariant and consistent anomalies. (orig.)

  8. Automatic Multi Document Summarization Approaches

    Directory of Open Access Journals (Sweden)

    Yogan J. Kumar

    2012-01-01

    Full Text Available Problem statement: Text summarization can be of different nature ranging from indicative summary that identifies the topics of the document to informative summary which is meant to represent the concise description of the original document, providing an idea of what the whole content of document is all about. Approach: Single document summary seems to capture both the information well but it has not been the case for multi document summary where the overall comprehensive quality in presenting informative summary often lacks. It is found that most of the existing methods tend to focus on sentence scoring and less consideration is given to the contextual information content in multiple documents. Results: In this study, some survey on multi document summarization approaches has been presented. We will direct our focus notably on four well known approaches to multi document summarization namely the feature based method, cluster based method, graph based method and knowledge based method. The general ideas behind these methods have been described. Conclusion: Besides the general idea and concept, we discuss the benefits and limitations concerning these methods. With the aim of enhancing multi document summarization, specifically news documents, a novel type of approach is outlined to be developed in the future, taking into account the generic components of a news story in order to generate a better summary.

  9. Oncoplastic Approaches to Breast Conservation

    International Nuclear Information System (INIS)

    When a woman is diagnosed with breast cancer many aspects of her physical, emotional, and sexual wholeness are threatened. The quickly expanding field of oncoplastic breast surgery aims to enhance the physician commitment to restore the patient's image and self-assurance. By combining a multidisciplinary approach to diagnosis and treatment with oncoplastic surgery, successful results in the eyes of the patient and physician are significantly more likely to occur. As a way to aid oncoplastic teams in determining which approach is most suitable for their patient's tumor size, tumor location, body habitus, and desired cosmetic outcome we present a review of several oncoplastic surgical approaches. For resections located anywhere in the breast, the radial ellipse segmentectomy incision and circumareolar approach for segmental resection are discussed. For resections in the upper or central breast, crescent mastopexy, the batwing incision, the hemi batwing incision, donut mastopexy, B-flap resection, and the central quadrantectomy are reviewed. For lesions of the lower breast, the triangle incision, infra mammary incision, and reduction mastopexy are discussed. Surgeons who are interested in adding oncoplastic breast conserving therapies to their skill sets are encouraged to implement these surgical techniques where applicable and to seek out breast fellowships or enhanced training when appropriate

  10. Multidisciplinary Approaches in Evolutionary Linguistics

    Science.gov (United States)

    Gong, Tao; Shuai, Lan; Wu, Yicheng

    2013-01-01

    Studying language evolution has become resurgent in modern scientific research. In this revival field, approaches from a number of disciplines other than linguistics, including (paleo)anthropology and archaeology, animal behaviors, genetics, neuroscience, computer simulation, and psychological experimentation, have been adopted, and a wide scope…

  11. Anterior Approach Total Hip Replacement

    Medline Plus

    Full Text Available ... over top of the ilium. Yeah. We’re using only part of what’s called the “Smith-Peterson approach.” The true ... templating Roger, accurate, not accurate, using packs, not using packs? We actually do both. We’re sort of in that transition. No, I think the templating ...

  12. Towards a Taxonomy of Dynamic Reconfiguration Approaches

    Directory of Open Access Journals (Sweden)

    Mohammad Charaf Eddin

    2013-09-01

    Full Text Available Dynamic reconfiguration is essential part of software evolution. Several approaches to support dynamic reconfiguration have been proposed in the literature. These approaches are different in various criteria. The goal of this work is to make a comparative study between various dynamic reconfiguration approaches by exploring the features of these approaches and to classify them with respect to these features.

  13. Anterior intrapelvic modification to the ilioinguinal approach.

    Science.gov (United States)

    Hagen, Jennifer E; Weatherford, Brian M; Nascone, Jason W; Sciadini, Marcus F

    2015-02-01

    Anterior approaches to the pelvis for acetabular surgery require an intimate knowledge of pelvic anatomy. The utilitarian anterior approach is the ilioinguinal approach. This article will describe a technique for modifying the medial window of the ilioinguinal approach to facilitate intrapelvic visualization and instrumentation not afforded in the original technique as described by Letournel. PMID:25486000

  14. New Approach for Image Fusion Based on Curvelet Approach

    Directory of Open Access Journals (Sweden)

    Gehad Mohamed Taher

    2014-08-01

    Full Text Available Most of the image fusion work has been limited to monochrome images. Algorithms which utilize human colour perception are attracting the image fusion community with great interest. It is mainly due to the reason that the use of colour greatly expands the amount of information to be conveyed in an image. Since, the human visual system is very much sensitive to colours; research was undertaken in mapping three individual monochrome multispectral images to the respective channels of an RGB image to produce a false colour fused image. Producing a fused colour output image which maintains the original chromaticity of the input visual image is highly tricky. The focus of this paper is developing a new approach to fuse a color image (visual image and a corresponding grayscale one (Infrared image – IR using the curvelet approach using different fusion rules in new fields. The fused image obtained by the proposed approach maintain the high resolution of the colored image (visual image, incorporate any hidden object given by the IR sensor as an example, or complements the two input images and keep the natural color of the visual image.

  15. Commercial dissemination approaches for solar home systems

    Energy Technology Data Exchange (ETDEWEB)

    Terrado, E.

    1997-12-01

    The author discusses the issue of providing solar home systems to primarily rural areas from the perspective of how to commercialize the process. He considers two different approaches, one an open market approach and the other an exclusive market approach. He describes examples of the exclusive market approach which are in process in Argentina and Brazil. Coming from a banking background, the business aspects are discussed in detail. He points out the strengths and weaknesses of both approaches toward developing such systems.

  16. Fuzzy multiple linear regression: A computational approach

    Science.gov (United States)

    Juang, C. H.; Huang, X. H.; Fleming, J. W.

    1992-01-01

    This paper presents a new computational approach for performing fuzzy regression. In contrast to Bardossy's approach, the new approach, while dealing with fuzzy variables, closely follows the conventional regression technique. In this approach, treatment of fuzzy input is more 'computational' than 'symbolic.' The following sections first outline the formulation of the new approach, then deal with the implementation and computational scheme, and this is followed by examples to illustrate the new procedure.

  17. Novel approaches in herbal cosmetics.

    Science.gov (United States)

    Chanchal, Deep; Swarnlata, Saraf

    2008-06-01

    Nutracosmetics are an emerging class of health and beauty aid products that combine the benefits of nutracosmetical ingredients with the elegance, skin feel, and delivery systems of cosmetics. Herbs and spices have been used in maintaining and enhancing human beauty because herbs have many beneficial properties, such as sunscreen, antiaging, moisturizing, antioxidant, anticellulite, and antimicrobial effects. As compared with synthetic cosmetic products, herbal products are mild, biodegradable, and have low toxicity profile. To enhance these properties, research is being done in the development of newer approaches, which could improve both the aesthetic appeal and performance of a cosmetic product. In this respect, the approaches studied and discussed include liposomes, phytosomes, transferosomes, nanoemulsions, nanoparticles, microemulsions, nanocrystals, and cubosomes. PMID:18482010

  18. New Approaches to Classical Liberalism

    Directory of Open Access Journals (Sweden)

    Nicolas Maloberti

    2012-01-01

    Full Text Available This article focuses on the following three novel and original philosophical approaches to classical liberalism: Den Uyl and Rasmussen's perfectionist argument from meta-norms, Gaus's justificatory model, and Kukathas's conscience-based theory of authority. None of these three approaches are utilitarian or consequentialist in character. Neither do they appeal to the notion of a rational bargain as it is typical within contractarianism. Furthermore, each of these theories rejects the idea that classical liberalism should be grounded on considerations of interpersonal justice such as those that are central to the Lockean tradition. It is argued that these three theories, despite their many attractive features, fail to articulate in a convincing manner some central classical liberal concerns.

  19. Virtualization Approaches in Cloud Computing

    Directory of Open Access Journals (Sweden)

    K C Gouda

    2014-06-01

    Full Text Available In the growing age of cloud computing demands in almost all the sectors like TV channel to online shopping to educational institution etc., the cloud infrastructure cost goes very high. Therefore, the concept of virtualization needs to be understand and implement in the cloud computing syterms, which enables the user as well as the owners for the better and robust management and usage of the cloud. In this paper the virtualization approach in the cloud computing environment are well presented with the concept of the cloud service models. The virtualization process and implementation with their advantages are documented and the different types of virtualizations are presented with some survey on the Indian data centre and the virtualization architecture. This approach needs to be evaluated in different cloud platforms for finding the cost effectiveness in the cloud infrastructure development.

  20. Bayesian approach to rough set

    CERN Document Server

    Marwala, Tshilidzi

    2007-01-01

    This paper proposes an approach to training rough set models using Bayesian framework trained using Markov Chain Monte Carlo (MCMC) method. The prior probabilities are constructed from the prior knowledge that good rough set models have fewer rules. Markov Chain Monte Carlo sampling is conducted through sampling in the rough set granule space and Metropolis algorithm is used as an acceptance criteria. The proposed method is tested to estimate the risk of HIV given demographic data. The results obtained shows that the proposed approach is able to achieve an average accuracy of 58% with the accuracy varying up to 66%. In addition the Bayesian rough set give the probabilities of the estimated HIV status as well as the linguistic rules describing how the demographic parameters drive the risk of HIV.

  1. Ecosystemic approaches to land degradation

    International Nuclear Information System (INIS)

    Land degradation is recognized as the main outcome of desertification. However available procedures for its assessment are still unsatisfactory because are often too costly for surveying large areas and rely on specific components of the degradation process without being able to integrate them in a unique process. One of the objectives of De Survey project is designing and implementing operational procedures for desertification surveillance, including land degradation. A strategic report was compiled and reproduced here for selecting the most appropriate approaches to the project conditions. The report focuses on using attributes of ecosystem maturity as a natural way to integrate the different drivers of land degradation in simple indices. The review surveys different families of attributes concerned with water and energy fluxes through the ecosystem, its capacity to sustain biomass and net primary productivity, and its capacity to structure the space. Finally, some conclusions are presented about the choice criteria of the different approaches in the framne of operational applications. (Author) 20 refs.

  2. Nanorobotics current approaches and techniques

    CERN Document Server

    Ferreira, Antoine

    2013-01-01

    Nanorobot devices now perform a wide variety of tasks at the nanoscale in a wide variety of fields including but not limited to fields such as manufacturing, medicine, supply chain, biology, and outer space. Nanorobotics: Current Approaches and Techniques is a comprehensive overview of this interdisciplinary field with a wide ranging discussion that includes nano-manipulation and industrial nanorobotics, nanorobotics in biology and medicine, nanorobotic sensing, navigation and swarm behavior, and protein and DNA-based nanorobotics. Also included is the latest on topics such as bio-nano-actuators and propulsion and navigation of nanorobotic systems using magnetic fields. Nanorobotics: Current Approaches and Techniques is an ideal book for scientists, researchers, and engineers actively involved in applied and robotic research and development.

  3. Variational approach in dislocation theory

    OpenAIRE

    Groma, István; Györgyi, Géza; Ispánovity, Péter Dusán

    2009-01-01

    A variational approach is presented to calculate the stress field generated by a system of dislocations. It is shown that in the simplest case, when the material containing the dislocations obeys Hooke's law the variational framework gives the same field equations as Kr\\"oner's theory. However, the variational method proposed allows to study many other problems like dislocation core regularisation, role of elastic anharmonicity and dislocation--solute atom interaction. The a...

  4. Stock Mechanics: a classical approach

    OpenAIRE

    Tuncay, Caglar

    2005-01-01

    New theoretical approaches about forecasting stock markets are proposed. A mathematization of the stock market in terms of arithmetical relations is given, where some simple (non-differential, non-fractal) expressions are also suggested as general stock price formuli in closed forms which are able to generate a variety of possible price movements in time. A kind of mechanics is submitted to cover the price movements in terms of classical concepts. Where utilizing stock mecha...

  5. Computational approaches to energy materials

    CERN Document Server

    Catlow, Richard; Walsh, Aron

    2013-01-01

    The development of materials for clean and efficient energy generation and storage is one of the most rapidly developing, multi-disciplinary areas of contemporary science, driven primarily by concerns over global warming, diminishing fossil-fuel reserves, the need for energy security, and increasing consumer demand for portable electronics. Computational methods are now an integral and indispensable part of the materials characterisation and development process.   Computational Approaches to Energy Materials presents a detailed survey of current computational techniques for the

  6. Interdisciplinary Approach in Engineering Education

    OpenAIRE

    Anda Zeidmane; Sarmite Cernajeva

    2011-01-01

    The analysis of the scientific literature available on the types of general competences and their classification caused the authors to conclude that it is necessary to implement interdisciplinary approach in engineering education to develop competences necess...

  7. Biotechnological approaches to rose breeding

    OpenAIRE

    Marchant, Robert

    1994-01-01

    The production of new rose cultivars by sexual crossing is problematic and time consuming due to sexual incompatibility. the failure of seeds to genninate. and to a limited gene pool. Biotechnology provides an obvious alternative for the creation of genetic novelty in rose. This thesis focuses on the development of novel approaches, based on embryo rescue, pollen cryopreservation, protoplast and transformation technologies. A reproducible embryo rescue technique was developed in which embr...

  8. Accident management approach in Armenia

    International Nuclear Information System (INIS)

    In this lecture the accident management approach in Armenian NPP (ANPP) Unit 2 is described. List of BDBAs had been developed by OKB Gydropress in 1994. 13 accident sequences were included in this list. The relevant analyses had been performed in VNIIAES and the 'Guidelines on operator actions for beyond design basis accident (BDBA) management at ANPP Unit 2' had been prepared. These instructions are discussed

  9. Energetic approach for ductile tearing

    International Nuclear Information System (INIS)

    This study focuses on ductile crack initiation and propagation. It aims to propose an approach for the engineer allowing the prediction of the evolution of cracks in large scale components, from parameters determined on laboratory specimens. A crack initiation criterion, defining a Ji tenacity related to crack tip blunting proposed in the literature is validated in the study. This criterion is shown to be transferable from laboratory specimens to structures. The literature review shows that an approach based on the dissipated energy in the fracture process during propagation offers an economical and simple solution to simulate large crack growth. A numerical method is proposed to estimate this fracture energy. The existence of an energy parameter Gfr is shown, by simulating the propagation by the simultaneous release of several elements and by the use of the Rice integral with an original integration path. This parameter represents the needed energy for a unit crack extension and appears to be intrinsic to the material. A global energy statement allows to relate this parameter to a variation of the plastic part of J integral. It offers a second numerical method to simulate the propagation just from stationary numerical calculations, as well as the elaboration of a simplified method. This approach, using two parameters Ji and Gfr, intrinsic to the material and experimentally measurable on specimens, is validated on many tests such as crack pipes subjected to four points bending and cracked rings in compression. For example, this approach allows to model up to 90 mm ductile tearing in a pipe with a circumferential through-wall crack in ferritic steel, or to anticipate the evolution of a semi-elliptical crack in an aged austenitic ferritic steel plate subjected to bending. (author)

  10. Clinical approach to young hypertension.

    OpenAIRE

    Sukor, Norlela

    2013-01-01

    Hypertension affects approximately 30% of the population worldwide. It is a serious disease, expensive to treat, and can lead to long-term morbidity and mortality. Young hypertension, defined as hypertension occurring in patients aged 40 or younger, is now seen more frequently. A correct and holistic approach in the evaluation of patients with suspected young hypertension is essential, as the underlying cause is demonstrable in more than half of the cases. Among these causes include primary a...

  11. Imbalanced Data Learning Approaches Review

    Directory of Open Access Journals (Sweden)

    Mohamed Bekkar

    2013-07-01

    Full Text Available The present work deals with a well-known problem inmachine learning, that classes have generallyskewed prior probabilities distribution. This situation of imbalanced data is a handicap when tryingtoidentify the minority classes , usually more interesting one In real world applications. This paper isanattempt to list the different approachs proposed inscientific research to deal with the imbalanced datalearning, as well a comparison between various applications cases performed on this subject.

  12. Approaches to Understanding Cosmic Acceleration

    OpenAIRE

    Silvestri, Alessandra; Trodden, Mark

    2009-01-01

    Theoretical approaches to explaining the observed acceleration of the universe are reviewed. We briefly discuss the evidence for cosmic acceleration, and the implications for standard General Relativity coupled to conventional sources of energy-momentum. We then address three broad methods of addressing an accelerating universe: the introduction of a cosmological constant, its problems and origins; the possibility of dark energy, and the associated challenges for fundamental...

  13. Material Systems : a design approach

    DEFF Research Database (Denmark)

    Jensen, Mads Brath; Mortensen, Henrik Rubæk

    2009-01-01

    This paper describes and reflects upon the results of an investigative project which explores the setting up of a material system - a parametric and generative assembly consisting of and taking into consideration material properties, manufacturing constraints and geometric behaviour. The project approaches the subject through the construction of a logic-driven system aiming to explore the possibilities of a material system that fulfills spatial, structural and performative requirements concurrently and how these are negotiated in situations where they might be conflicting.

  14. Corporate Governance: An Institutionalist Approach

    OpenAIRE

    Cobbaut, Robert; Lenoble, Jacques

    2003-01-01

    Even though our understanding of corporate governance has evolved from a rigid model of “command and control” toward a more flexible model of incentive mechanisms, numerous and major shortcomings continue to plague efforts to resolve the conflicts of interest inherent in the managerial approach to corporate control. In this stimulating book the work of ten outstanding scholars in the field converges, along different avenues of research and analysis, toward a vital critique of two assumpti...

  15. Energy mastery: context, stakes, approaches

    International Nuclear Information System (INIS)

    Any energy use has both an environmental and an economical impact. The environmental stakes linked with the energy use impose to adapt the policies and practices towards a more rational use of energy sources and towards the improvement of energy systems efficiency. This document deals with the national and international context, the economical, energetic and environmental stakes and with the political and technical approaches of energy mastery. It is illustrated with the mastery of power demand. (J.S.)

  16. An Approach for Groundwater Modeling

    International Nuclear Information System (INIS)

    The paper describes a simplified model for transport analysis of radioactive solution by the groundwater flow. The fundamental concept upon which the model is based consists of introducing the so-called concentration reduction factor (CRFs) of radioactive solution in the groundwater. These factors should be understood as a dimensionless measure of isolation analyzed by the model. The first part of the paper contains a brief mathematical description, while the second part demonstrates applicability of the simplified approach. (author)

  17. An Environmentalist Approach: Green Design

    OpenAIRE

    Gulay Coskun Kasap; Deniz Peker

    2011-01-01

    A product interacts with the environment throughout the entire life cycle- from the design phase to disposal phase- and every product makes different environmental impacts in different life cycle stages. Thus, reducing the environmental impact of a product by just focusing on the waste that is produced after the production process, is not possible. For this, a holistic and proactive approach adoption is required which considers the entire life of a product from raw materials that will be us...

  18. Humanoid Introspection: A Practical Approach

    Directory of Open Access Journals (Sweden)

    Ignazio Infantino

    2013-05-01

    Full Text Available We describe an approach to robot introspection based on self observation and communication. Self observation is what the robot should do in order to build, represent and understand its internal state. It is necessary to translate the state representation in order to build a suitable input to an ontology that supplies the meaning of the internal state. The ontology supports the linguistic level that is used to communicate information about the robot state to the human user.

  19. Humanoid Introspection: A Practical Approach

    OpenAIRE

    Ignazio Infantino; Giovanni Pilato; Riccardo Rizzo; Filippo Vella

    2013-01-01

    We describe an approach to robot introspection based on self observation and communication. Self observation is what the robot should do in order to build, represent and understand its internal state. It is necessary to translate the state representation in order to build a suitable input to an ontology that supplies the meaning of the internal state. The ontology supports the linguistic level that is used to communicate information about the robot state to the human user.

  20. Neuromodulation: Selected approaches and challenges

    OpenAIRE

    Parpura, Vladimir; Silva, Gabriel A.; Tass, Peter A.; Bennet, Kevin E.; Meyyappan, Meyya; Koehne, Jessica; Lee, Kendall H.; Andrews, Russell J.

    2012-01-01

    The brain operates through complex interactions in the flow of information and signal processing within neural networks. The “wiring” of such networks, being neuronal or glial, can physically and/or functionally go rogue in various pathological states. Neuromodulation, as a multidisciplinary venture, attempts to correct such faulty nets. In this review, selected approaches and challenges in neuromoduation are discussed. The use of water-dispersible carbon nanotubes have proven effective i...

  1. Evolutionary approaches to legal change

    OpenAIRE

    Eckardt, Martina

    2004-01-01

    Institutions matter both for long-term economic evolution as well as for more short-termed economic performance. The law is particularly important in shaping the institutional framework for economic activities. This paper gives an overview of typical evolutionary explanations of legal change, i.e. the generation and dissemination of legal innovations over time. The main actors, the key determinants, and the central mechanisms are identified. In addition to approaches which deal primarily with...

  2. Industrial Beamline Technologies And Approaches

    Science.gov (United States)

    Dehnel, M. P.

    2011-06-01

    This paper describes industrial charged particle beamline technologies and design approaches. Beamlines accommodate myriad constraints in the radioisotope production, electron beam processing, and ion implantation market segments, and some very strange yet interesting solutions result. In this paper, a detailed look at a particular injection beamline solution gives some sense of the complexity of research and development required, and the sophistication of the beamline solutions that are utilized. A brief review of beamline applications in each industrial segment follows.

  3. Future fuel: Vattenfall's new approach

    International Nuclear Information System (INIS)

    The Swedish utility, Vattenfall Fuel, has set up a number of requirements for the fuel of the future in order to improve fuel reliability, increase operational flexibility and safety margins, and decrease collective dose. The elements of their strategy are outlined. These include: a more restrictive approach to Lead Fuel Assembly; improved verification; better focussed R and D; and an improved fuel purchase process. (author)

  4. Optimization approach to entanglement distillation

    OpenAIRE

    Opatrny, T.; Kurizki, G.

    1998-01-01

    We put forward a method for optimized distillation of partly entangled pairs of qubits into a smaller number of more entangled pairs by recurrent local unitary operations and projections. Optimized distillation is achieved by minimization of a cost function with up to 30 real parameters, which is chosen to be sensitive to the fidelity and the projection probability at each step. We show that in many cases this approach can significantly improve the distillation efficiency in...

  5. Transcriptional approaches to riboswitch studies

    OpenAIRE

    Mironov, Alexander; Epshtein, Vitaly; Nudler, Evgeny

    2009-01-01

    Natural RNA sensors of small molecules (a.k.a. riboswitches) regulate numerous metabolic genes. In bacteria, these RNA elements control transcription termination and translation initiation by changing the folding pathway of nascent RNA upon direct binding of a metabolite. To identify and study riboswitches we used in vitro reconstituted solid-phase transcription elongation/termination system. This approach allows for direct monitoring ligand binding and riboswitch functioning, establishing th...

  6. Diagnostic approach to peripheral neuropathy

    OpenAIRE

    Misra Usha; Kalita Jayantee; Nair Pradeep

    2008-01-01

    Peripheral neuropathy refers to disorders of the peripheral nervous system. They have numerous causes and diverse presentations; hence, a systematic and logical approach is needed for cost-effective diagnosis, especially of treatable neuropathies. A detailed history of symptoms, family and occupational history should be obtained. General and systemic examinations provide valuable clues. Neurological examinations investigating sensory, motor and autonomic signs help to define the topography an...

  7. Oncoplastic Approaches to Breast Conservation

    OpenAIRE

    Holmes, Dennis R.; Schooler, Wesley; Smith, Robina

    2011-01-01

    When a woman is diagnosed with breast cancer many aspects of her physical, emotional, and sexual wholeness are threatened. The quickly expanding field of oncoplastic breast surgery aims to enhance the physician commitment to restore the patient's image and self-assurance. By combining a multidisciplinary approach to diagnosis and treatment with oncoplastic surgery, successful results in the eyes of the patient and physician are significantly more likely to occur. As a way to aid oncoplastic t...

  8. Diagrammatic approach to quantum search

    Science.gov (United States)

    Wong, Thomas G.

    2015-06-01

    We introduce a simple diagrammatic approach for estimating how a randomly walking quantum particle searches on a graph in continuous time, which involves sketching small weighted graphs with self-loops and considering degenerate perturbation theory's effects on them. Using this method, we give the first example of degenerate perturbation theory solving search on a graph whose evolution occurs in a subspace whose dimension grows with.

  9. Fulfillment Request Management (The approach)

    OpenAIRE

    Stylianos Gkoutzioupas

    2014-01-01

    In this paper we introduce the term FRM (Fulfillment Request Management). According to the FRM in a BSS / OSS environment we can use a unified approach to implement a SOA in order to integrate BSS with OSS and handle 1. Orders 2. Events 3. Processes. So in a way that systems like ESB, Order Management, and Business Process Management can be implemented under a unified architecture and a unified implementation. We assume that all the above mentioned are 'requests' and accordi...

  10. The thermodynamic approach to market

    OpenAIRE

    Sergeev, Victor

    2008-01-01

    The first (Russian) edition of the book was among the first monographs on econophysics. The book gives an explanation of several intriguing phenomena, providing new insights and answers to some deeply vexing questions. Why the economic "shock therapy" implemented in Eastern Europe was doomed to a failure whereas the approach adopted by China and Vietnam should inevitably lead to economic growth (damped, perhaps, by corruption and inconsistencies)? Why some restrictions i...

  11. Alternative systematic approaches to training

    Energy Technology Data Exchange (ETDEWEB)

    1995-01-01

    This handbook is approved for use by all DOE Components and contractors. The handbook was prepared primarily for DOE nuclear facilities, but the information can be effectively used by any other type of facility. DOE nuclear, DOE non-nuclear, commercial nuclear reactor, fuel fabrication, chemical processing, or other types of facilities may also apply the principles of this approach and find it useful and applicable to local needs. The handbook provides DOE and contractor operating organizations with concepts and guidance regarding the use of alternative techniques to implement a systematic approach to training (SAT). The techniques described in this handbook are endorsed by DOE and use of the guidance in this handbook is appropriate for establishment of technical training programs at DOE nuclear facilities. The use of guidance on selection and implementation of appropriate training approaches after consideration of job complexity, the consequences of error based on risk/hazard potential, and available training media should result in effective and efficient training programs. The information presented in this handbook can be used to grade the level of effort and formality used in developing training programs.

  12. Neuromodulation: selected approaches and challenges.

    Science.gov (United States)

    Parpura, Vladimir; Silva, Gabriel A; Tass, Peter A; Bennet, Kevin E; Meyyappan, M; Koehne, Jessica; Lee, Kendall H; Andrews, Russell J

    2013-02-01

    The brain operates through complex interactions in the flow of information and signal processing within neural networks. The 'wiring' of such networks, being neuronal or glial, can physically and/or functionally go rogue in various pathological states. Neuromodulation, as a multidisciplinary venture, attempts to correct such faulty nets. In this review, selected approaches and challenges in neuromodulation are discussed. The use of water-dispersible carbon nanotubes has been proven effective in the modulation of neurite outgrowth in culture and in aiding regeneration after spinal cord injury in vivo. Studying neural circuits using computational biology and analytical engineering approaches brings to light geometrical mapping of dynamics within neural networks, much needed information for stimulation interventions in medical practice. Indeed, sophisticated desynchronization approaches used for brain stimulation have been successful in coaxing 'misfiring' neuronal circuits to resume productive firing patterns in various human disorders. Devices have been developed for the real-time measurement of various neurotransmitters as well as electrical activity in the human brain during electrical deep brain stimulation. Such devices can establish the dynamics of electrochemical changes in the brain during stimulation. With increasing application of nanomaterials in devices for electrical and chemical recording and stimulating in the brain, the era of cellular, and even intracellular, precision neuromodulation will soon be upon us. PMID:23190025

  13. Technical approach to groundwater restoration

    International Nuclear Information System (INIS)

    The Technical Approach to Groundwater Restoration (TAGR) provides general technical guidance to implement the groundwater restoration phase of the Uranium Mill Tailings Remedial Action (UMTRA) Project. The TAGR includes a brief overview of the surface remediation and groundwater restoration phases of the UMTRA Project and describes the regulatory requirements, the National Environmental Policy Act (NEPA) process, and regulatory compliance. A section on program strategy discusses program optimization, the role of risk assessment, the observational approach, strategies for meeting groundwater cleanup standards, and remedial action decision-making. A section on data requirements for groundwater restoration evaluates the data quality objectives (DQO) and minimum data required to implement the options and comply with the standards. A section on sits implementation explores the development of a conceptual site model, approaches to site characterization, development of remedial action alternatives, selection of the groundwater restoration method, and remedial design and implementation in the context of site-specific documentation in the site observational work plan (SOWP) and the remedial action plan (RAP). Finally, the TAGR elaborates on groundwater monitoring necessary to evaluate compliance with the groundwater cleanup standards and protection of human health and the environment, and outlines licensing procedures

  14. A Flexible Table Parsing Approach

    Scientific Electronic Library Online (English)

    Frank, Schilder; Ravi, Kondadadi; Yana, Kadiyska.

    2012-06-01

    Full Text Available Relational data is often encoded in tables. Tables are easy to read by humans, but difficult to interpret automatically. In cases where table layout cues are not obtainable (missing HTML tags) or where columns are distorted (by copying from a spreadsheet to text) previous table extraction approaches [...] run into problems. This paper introduces a novel table parsing approach. Our approach is based on a set of simple assumptions: (a) every table can be split up in data cells and headers, and (b) every table can be parsed beginning from a data cell utilizing the overall table structure. The table parsing is defined as "table flattening" in this paper. That is, the parsing starts with a data cell and pulls out all token (i.e., headers and sub-headers) associated with a respective data cell. We propose a parsing technique that uses two simple parsing heuristics: table headers are to the left of and above a data cell. We experimented with trader emails that contained instrument information with bid-ask prices as data cells. We developed a clustering and classifying method for finding prices reliably in the data set we used. This method is transferable to other data cell types and can be applied to other table content.

  15. An abstract approach to music.

    Energy Technology Data Exchange (ETDEWEB)

    Kaper, H. G.; Tipei, S.

    1999-04-19

    In this article we have outlined a formal framework for an abstract approach to music and music composition. The model is formulated in terms of objects that have attributes, obey relationships, and are subject to certain well-defined operations. The motivation for this approach uses traditional terms and concepts of music theory, but the approach itself is formal and uses the language of mathematics. The universal object is an audio wave; partials, sounds, and compositions are special objects, which are placed in a hierarchical order based on time scales. The objects have both static and dynamic attributes. When we realize a composition, we assign values to each of its attributes: a (scalar) value to a static attribute, an envelope and a size to a dynamic attribute. A composition is then a trajectory in the space of aural events, and the complex audio wave is its formal representation. Sounds are fibers in the space of aural events, from which the composer weaves the trajectory of a composition. Each sound object in turn is made up of partials, which are the elementary building blocks of any music composition. The partials evolve on the fastest time scale in the hierarchy of partials, sounds, and compositions. The ideas outlined in this article are being implemented in a digital instrument for additive sound synthesis and in software for music composition. A demonstration of some preliminary results has been submitted by the authors for presentation at the conference.

  16. Fighting corruption – a philosophical approach

    Directory of Open Access Journals (Sweden)

    Schalk W. Vorster

    2013-07-01

    Full Text Available Corruption has reached astounding proportions in South Africa. The purpose of this article is to contribute to philosophical approaches aimed at combating corruption. In considering punishment for acts of corruption the most common approach is based on the philosophical theory of consequentialism, which allows only consideration of the consequences of corrupt acts. Ideally, cognisance should be taken of the norms in question, especially those norms demanding the judicious execution of obligations. It was, however, found that the Kantian categorical imperative presupposes an ideal rational society. The imperative has to be ‘softened’ by also allowing for enquiry about the corruptor’s personal circumstances, in the light of Christ’s love commandment. This article highlights the most prominent attributes of two important philosophical theories applicable to the study of corruption, namely utilitarianism (a variant of consequentialism and deontology. It is argued that qualified deontological and utilitistic approaches hold the best promise to curb corruption in the long run. The conclusion is that the state will urgently have to attend to the social context by revitalising programmes of ‘social renewal’, based on effective application of the law, the provision of adequate education and the eradication of poverty. There is also an urgent need for the ‘moral renewal’ of the entire population, focused on Christian values, operationalised within the context of the South Africa of today. Herein lies a massive task for the church.

  17. Practical approaches to neurogenetic disease.

    Science.gov (United States)

    Lynch, David R; Farmer, Jennifer

    2002-12-01

    Over the past 15 years, molecular genetic advances have led to new approaches for evaluation of neurogenetic disease. New diagnostic tests are available, and in some cases new diseases have been defined. However, effective use of these new tests still relies on solid clinical assessment to prioritize testing and interpret results. This review presents applications of genetic advances to a series of neurogenetic disorders, emphasizing the specific uses of genetic testing and the clinical questions that may arise. The rapid expansion in molecular diagnostics and genomics has fundamentally changed the approach to neurogenetic illnesses. Use of molecular biologic techniques has elucidated new disease mechanisms and allowed the application of genetic concepts to classically nongenetic illnesses. This has led to a wealth of new clinical information and created new dilemmas in patient care. In addition, it has brought into common usage a series of clinical genetic terms, such as variable expressivity (the range of phenotypic features in which the same disease can manifest) and anticipation (the progressively earlier age of onset of a specific disease in a family). This review provides a practical approach for neurogenetic evaluation of individuals who are likely to present in neuro-ophthalmologic practices with inherited ataxias, myotonic dystrophy, oculopharyngeal dystrophy, and Parkinson disease. PMID:12464734

  18. Approach Merotopological Spaces and their Completion

    Directory of Open Access Journals (Sweden)

    Surabhi Tiwari

    2010-01-01

    Full Text Available This paper introduces the concept of an approach merotopological space and studies its category-theoretic properties. Various topological categories are shown to be embedded into the category whose objects are approach merotopological spaces. The order structure of the family of all approach merotopologies on a nonempty set is discussed. Employing the theory of bunches, bunch completion of an approach merotopological space is constructed. The present study is a unified look at the completion of metric spaces, approach spaces, nearness spaces, merotopological spaces, and approach merotopological spaces.

  19. 33 CFR 167.203 - In the approaches to Chesapeake Bay: Southern approach.

    Science.gov (United States)

    2010-07-01

    ...2010-07-01 2010-07-01 false In the approaches to Chesapeake Bay: Southern approach. 167.203 Section 167.203 Navigation...Atlantic East Coast § 167.203 In the approaches to Chesapeake Bay: Southern...

  20. Project Supervision – An Engineering Approach

    DEFF Research Database (Denmark)

    Paulsen, Rasmus Reinhold; Larsen, Rasmus

    2011-01-01

    For more than twenty years, a group based supervision strategy has been used when supervising engineering bachelor- and master thesis students at our research group. In recent years, we have formalised the approach and used our industry experience to create a very successful framework for project supervision. This paper is a best practice guide aiming at research groups that would like to try to implement our supervision approach or parts of it. The approach is based on the belief that engineering students should be prepared for their new role as development engineers or PhD students as part of their master thesis writing. The supervision principles are: Ownership: The student should feel that their project is their own. Ideally, they should formulate the project themselves. Write early: We strongly encourage the students to write and generate figures and images already from the first week of the project period. Management: The student is considered project manager of his own project. The supervisor is a guide or coach (or a project owner) Plans: The student is asked to write a project plan during the first week of the project together with a risk-analysis. Group Meetings: A group of students and supervisors meet every week on a fixed weekday. In our team, it is normal that one supervisor supervises three to five projects simultaneously. The core of the supervision is the weekly meetings where the students present what they have been doing and what they plan to do. By default, all students are present at all meetings. Weekly meetings are scheduled to be at a specific day at a specific place for the entire process.

  1. Energy storage a new approach

    CERN Document Server

    Zito, Ralph

    2010-01-01

    Energy Storage: A New Approach presents practical solutions to the problem of energy storage on a massive scale.  This revolutionary book describes   technologies that include basic chemical concepts that engineers have been practicing for years, but presents new material that could transform the energy industry.  Regardless where power is generated from-oil, natural gas, coal, solar, wind, or any of the other emerging sources- energy storage is something that the industry MUST learn and practice.  With the world energy demand increasing, mostly due to industrial growth in China

  2. Urban social movements: gender approaches

    OpenAIRE

    Muxí Martínez, Zaida; Magro Huertas, Tania

    2009-01-01

    At the end of the 60’s the so called Urban Social Movements were groups that coming from different locally rooted entities or associations, asked for new approaches to planning that meant taking care of people’s needs and memories. As a result of the experience that came from the gendered division of work, duties and spaces women had a deep and broad knowledge of the urban circumstances. At the very beginning of the Urban Social Movements in Barcelona we could find women’s meetings where t...

  3. Operational gaming an international approach

    CERN Document Server

    Ståhl, Ingolf

    1983-01-01

    Operational Gaming: An International Approach focuses on various research on this method of systems analysis. The text points out the value of this method in decision making, planning, and in the implementation of policies. The book presents a survey that highlights the connection of experimental gaming, game theory, and operational gaming. The value of gaming as a balancing method in assessing multifaceted computer models, most notably about their assumptions on human behavior, is noted. The book also offers an overview of gaming in other countries, such as Bulgaria, Soviet Union, and Japan,

  4. Nonpharmacologic approach to sleep disorders.

    Science.gov (United States)

    Mansel, J Keith; Carey, Elise C

    2014-01-01

    Sleep disturbances are common in patients with cancer, occurring throughout the disease trajectory and sometimes well after treatment has concluded. Insomnia often does not occur in isolation; it may be associated with pain, fatigue, depression, and medication usage. Screening for sleep disturbances is an essential part of caring for oncologic patients. The criterion standard for nonpharmacologic treatment of insomnia in these patients is cognitive-behavioral therapy, a multimodal approach using sleep hygiene and education, stimulus control, sleep restriction, and relaxation. Exercise and complementary and integrative medicine have been studied with varying results, and no firm recommendation can be made about their efficacy. PMID:25299144

  5. HEDR modeling approach: Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Shipler, D.B.; Napier, B.A.

    1994-05-01

    This report is a revision of the previous Hanford Environmental Dose Reconstruction (HEDR) Project modeling approach report. This revised report describes the methods used in performing scoping studies and estimating final radiation doses to real and representative individuals who lived in the vicinity of the Hanford Site. The scoping studies and dose estimates pertain to various environmental pathways during various periods of time. The original report discussed the concepts under consideration in 1991. The methods for estimating dose have been refined as understanding of existing data, the scope of pathways, and the magnitudes of dose estimates were evaluated through scoping studies.

  6. Approaches to wind resource verification

    Science.gov (United States)

    Barchet, W. R.

    1982-01-01

    Verification of the regional wind energy resource assessments produced by the Pacific Northwest Laboratory addresses the question: Is the magnitude of the resource given in the assessments truly representative of the area of interest? Approaches using qualitative indicators of wind speed (tree deformation, eolian features), old and new data of opportunity not at sites specifically chosen for their exposure to the wind, and data by design from locations specifically selected to be good wind sites are described. Data requirements and evaluation procedures for verifying the resource are discussed.

  7. Cognitive reasoning a formal approach

    CERN Document Server

    Anshakov, Oleg M

    2010-01-01

    Dealing with uncertainty, moving from ignorance to knowledge, is the focus of cognitive processes. Understanding these processes and modelling, designing, and building artificial cognitive systems have long been challenging research problems. This book describes the theory and methodology of a new, scientifically well-founded general approach, and its realization in the form of intelligent systems applicable in disciplines ranging from social sciences, such as cognitive science and sociology, through natural sciences, such as life sciences and chemistry, to applied sciences, such as medicine,

  8. The calculus a genetic approach

    CERN Document Server

    Toeplitz, Otto

    2007-01-01

    When first published posthumously in 1963, this book presented a radically different approach to the teaching of calculus.  In sharp contrast to the methods of his time, Otto Toeplitz did not teach calculus as a static system of techniques and facts to be memorized. Instead, he drew on his knowledge of the history of mathematics and presented calculus as an organic evolution of ideas beginning with the discoveries of Greek scholars, such as Archimedes, Pythagoras, and Euclid, and developing through the centuries in the work of Kepler, Galileo, Fermat, Newton, and Leibniz. Through this unique a

  9. Approaches to understanding cosmic acceleration

    International Nuclear Information System (INIS)

    Theoretical approaches to explaining the observed acceleration of the universe are reviewed. We briefly discuss the evidence for cosmic acceleration, and the implications for standard general relativity coupled to conventional sources of energy-momentum. We then address three broad methods of addressing an accelerating universe: the introduction of a cosmological constant, its problems and origins; the possibility of dark energy and the associated challenges for fundamental physics and the option that an infrared modification of general relativity may be responsible for the large-scale behavior of the universe.

  10. 'Lean' approach gives greater efficiency.

    Science.gov (United States)

    Call, Roger

    2014-02-01

    Adapting the 'Lean' methodologies used for many years by many manufacturers on the production line - such as in the automotive industry - and deploying them in healthcare 'spaces' can, Roger Call, an architect at Herman Miller Healthcare in the US, argues, 'easily remedy many of the inefficiencies' found within a healthcare facility. In an article that first appeared in the September 2013 issue of The Australian Hospital Engineer, he explains how 'Lean' approaches such as the 'Toyota production system', and 'Six Sigma', can be harnessed to good effect in the healthcare sphere. PMID:24620487

  11. Combined Approach for Image Segmentation

    Directory of Open Access Journals (Sweden)

    Shradha Dakhare

    2014-05-01

    Full Text Available Many image segmentation techniques have been developed over the past two decades for segmenting the images, which help for object recognition, occlusion boundary estimation within motion or stereo systems, image compression, image editing. In this, there is a combined approach for segmenting the image. By using histogram equalization to the input image, from which it gives contrast enhancement output image .After that by applying median filtering ,which will remove noise from contrast output image . At last I applied fuzzy c-mean clustering algorithm to denoising output image, which give segmented output image. In this way it produce better segmented image with less computation time.

  12. New approach to resonance crossing.

    Science.gov (United States)

    Franchetti, G; Zimmermann, F

    2012-12-01

    Time-varying nonlinear oscillatory systems produce phenomena of resonance crossing and trapping of particles in resonance islands. Traditionally, such processes have been analyzed in terms of adiabatic conditions. Considering, as an example, a simplified one-dimensional model describing the "electron-cloud pinch" during a bunch passage in a particle accelerator, here we present an approach to resonance trapping which does not require any adiabatic condition. Instead we introduce the concept of the attraction point and investigate invariance and scaling properties of motion close to the attraction point, considering a single resonance crossing. PMID:23368210

  13. Algebraic Approach to Algorithmic Logic

    Directory of Open Access Journals (Sweden)

    Bancerek Grzegorz

    2014-09-01

    Full Text Available We introduce algorithmic logic - an algebraic approach according to [25]. It is done in three stages: propositional calculus, quantifier calculus with equality, and finally proper algorithmic logic. For each stage appropriate signature and theory are defined. Propositional calculus and quantifier calculus with equality are explored according to [24]. A language is introduced with language signature including free variables, substitution, and equality. Algorithmic logic requires a bialgebra structure which is an extension of language signature and program algebra. While-if algebra of generator set and algebraic signature is bialgebra with appropriate properties and is used as basic type of algebraic logic.

  14. Palatini Approach Beyond Einstein's Gravity

    CERN Document Server

    Olmo, Gonzalo J

    2011-01-01

    I review recent results obtained for extensions of general relativity formulated within the Palatini formalism, an approach in which metric and connection are treated as independent geometrical entities. The peculiar dynamics of these theories, governed by second-order equations and having no new degrees of freedom, makes them specially suitable to address certain aspects of quantum gravity phenomenology, construct nonsingular bouncing cosmologies, and explore black hole interiors, which in the Reissner-Nordstrom case develop a compact core of finite density instead of a point-like singularity.

  15. European Whiteness? : A Critical Approach

    DEFF Research Database (Denmark)

    Blaagaard, Bolette

    2008-01-01

    Born out of the United States’ (U.S.) history of slavery and segregation and intertwined with gender studies and feminism, the field of critical whiteness studies does not fit easily into a European setting and the particular historical context that entails. In order for a field of European critical whiteness studies to emerge, its relation to the U.S. theoretical framework, as well as the particularities of the European context need to be taken into account.. The article makes a call for a multi-layered approach to take over from the identity politics so often employed in the fields of U.S. gender, race, and whiteness studies.

  16. Computer Networks A Systems Approach

    CERN Document Server

    Peterson, Larry L

    2011-01-01

    This best-selling and classic book teaches you the key principles of computer networks with examples drawn from the real world of network and protocol design. Using the Internet as the primary example, the authors explain various protocols and networking technologies. Their systems-oriented approach encourages you to think about how individual network components fit into a larger, complex system of interactions. Whatever your perspective, whether it be that of an application developer, network administrator, or a designer of network equipment or protocols, you will come away with a "big pictur

  17. Femoral approach to lead extraction.

    Science.gov (United States)

    Mulpuru, Siva K; Hayes, David L; Osborn, Michael J; Asirvatham, Samuel J

    2015-03-01

    Laser and radiofrequency energy-assisted lead extraction has greatly facilitated this complex procedure. Although success rates are high, in some instances alternate methods of extraction are required. In this review, we discuss techniques for femoral extraction of implanted leads and retained fragments. The major tools available, including commonly used snares and delivery tools, are discussed. We briefly describe combined internal jugular and femoral venous extraction approaches, as well as complimentary utilization of more than one technique via the femoral vein. Animated and procedural sequences are included to help the reader visualize the key components of these techniques. PMID:25311643

  18. Intelligent approaches to performance support

    Directory of Open Access Journals (Sweden)

    Ashok Banerji

    1994-12-01

    Full Text Available Electronic performance support systems provide an important method of meeting on-demand educational and training requirements. They also provide efficient and effective ways of enabling the knowledge and expertise within an organization to be shared. This paper discusses the design of a distributed electronic performance support system and the ways in which 'intelligent agents' based on expert systems and neural networks can be used to locate and share distributed expertise. A case study illustrating our approach to the implementation and use of intelligent agents is presented.

  19. Integrated Approach to Competitive Advantage

    Directory of Open Access Journals (Sweden)

    Edita Ragelskaja

    2011-07-01

    Full Text Available Environmental changes and globalization of markets make an impact on intense competition in almost all business sectors. Evolutionary changes influence companies to learn, adequately react, adapt to environmental changes and to change themselves. Such a situation has revealed the problems of competitive advan­tage of industry companies. Therefore the focus to the factors impacting competitive advantage is seen as timely and relevant. The authors of the paper analyze approaches to competitive advantage and the factors impacting competitive advantage. The integrated model of competitive advantage is proposed in the paper.Article in Lithuanian

  20. HEDR modeling approach: Revision 1

    International Nuclear Information System (INIS)

    This report is a revision of the previous Hanford Environmental Dose Reconstruction (HEDR) Project modeling approach report. This revised report describes the methods used in performing scoping studies and estimating final radiation doses to real and representative individuals who lived in the vicinity of the Hanford Site. The scoping studies and dose estimates pertain to various environmental pathways during various periods of time. The original report discussed the concepts under consideration in 1991. The methods for estimating dose have been refined as understanding of existing data, the scope of pathways, and the magnitudes of dose estimates were evaluated through scoping studies

  1. Real Analysis A Historical Approach

    CERN Document Server

    Stahl, Saul

    2011-01-01

    A provocative look at the tools and history of real analysis This new edition of Real Analysis: A Historical Approach continues to serve as an interesting read for students of analysis. Combining historical coverage with a superb introductory treatment, this book helps readers easily make the transition from concrete to abstract ideas. The book begins with an exciting sampling of classic and famous problems first posed by some of the greatest mathematicians of all time. Archimedes, Fermat, Newton, and Euler are each summoned in turn, illuminating the utility of infinite, power, and trigonome

  2. Bayesian Approach to Foreground Removal

    CERN Document Server

    Jewell, J; Levin, S

    1999-01-01

    Our ability to extract the maximal amount of information from future observations at gigahertz frequencies depends on our ability to separate the underlying cosmic microwave background (CMB) from galactic and extragalactic foregrounds. We review the separation problem and its formulation within Bayesian inference, give examples of specific solutions with particular choices of prior density, and finally comment on the generalization of Bayesian methods to a multi-resolution framework. We propose a strategy for the regularization of solutions allowing a spatially varying spectral index, and discuss possible computational approaches such as multi-scale stochastic relaxation.

  3. Evolutionary Approach for Model Refinement

    Science.gov (United States)

    Zimmerman, David C.; Yap, Keng; Hasselman, Timothy

    1999-07-01

    In this paper, Genetic Algorithm (GA) based approaches for finite element model topology and parameter adjustment are investigated. Genetic algorithms are one form of directed random search. The form of direction is based on Darwin's 'survival of the fittest' theories. In this paper, an advancement in GA theory is proposed and evaluated to enhance GA search characteristics. The GA-based model refinement process makes use of experimental data to evolve a better correlated finite element model. The model refinement problem is formulated such that the sensitivity of the update to the presence of either analytical or experimental closely spaced modes of vibration is reduced.

  4. Unified approach to dense matter

    Science.gov (United States)

    Park, Byung-Yoon; Lee, Hee-Jung; Vento, Vicente; Kim, Joon-Il; Min, Dong-Pil; Rho, Mannque

    2005-04-01

    We apply the Skyrme model to dense hadronic matter, which provides a unified approach to high density, valid in the large Nc limit. In our picture, dense hadronic matter is described by the classical soliton configuration with minimum energy for the given baryon number density. By incorporating the meson fluctuations on such ground state we obtain an effective Lagrangian for meson dynamics in a dense medium. Our starting point has been the Skyrme model defined in terms of pions, thereafter we have extended and improved the model by incorporating other degrees of freedom such as dilaton, kaons and vector mesons.

  5. Unified Approach to Dense Matter

    CERN Document Server

    Park, B Y; Vento, V; Kim, J I; Min, D P; Rho, M; Park, Byung-Yoon; Lee, Hee-Jung; Vento, Vicente; Kim, Joon-Il; Min, Dong-Pil; Rho, Mannque

    2004-01-01

    We apply the Skyrme model to dense hadronic matter, which provides a unified approach to high density, valid in the large Nc limit. In our picture, dense hadronic matter is described by the classical soliton configuration with minimum energy for the given baryon number density. By incorporating the meson fluctuations on such ground state we obtain an effective Lagrangian for meson dynamics in a dense medium. Our starting point has been the Skyrme model defined in terms of pions, thereafter we have extended and improved the model by incorporating other degrees of freedom such as dilaton, kaons and vector mesons.

  6. Location theory a unified approach

    CERN Document Server

    Nickel, Stefan

    2006-01-01

    Although modern location theory is now more than 90 years old, the focus of researchers in this area has been mainly problem oriented. However, a common theory, which keeps the essential characteristics of classical location models, is still missing.This monograph addresses this issue. A flexible location problem called the Ordered Median Problem (OMP) is introduced. For all three main subareas of location theory (continuous, network and discrete location) structural properties of the OMP are presented and solution approaches provided. Numerous illustrations and examples help the reader to bec

  7. New approach needed to HVAC

    International Nuclear Information System (INIS)

    Heating, ventilation and air conditioning (HVAC) systems currently used in nuclear power plants are a development of those used to provide comfort conditions in office blocks and similar buildings. A new approach is required to the design of HVAC systems, whose role in the safety regime of any nuclear power plant often appears to be under-estimated. Experience gained in the British offshore industry is discussed together with control systems, which in addition to controlling the heating/ventilating function, provide information at a central point with feedback to the plant concerned. Opportunities for refurbishment of existing nuclear power plants are described. (U.K.)

  8. Wilson's approach to quantum systems

    International Nuclear Information System (INIS)

    We discuss the relevance that the Wilson Renormalization Group approach to Bose systems has for quantum systems for which a functional Bosonization exists. The role of Matsubara frequencies as concerning the phenomenon of dimensional crossover is pointed out. Furthermore we find that the unusual critical behaviour of Bose system at T=0 can be included to first order in epsilon = 2-d, in the Wilson universality class with n = -2, with n the number of order parameter components. Finally, some consierations about other quantum systems are made. (author)

  9. Smile detection : A simple Approach

    Directory of Open Access Journals (Sweden)

    Praveen N

    2013-06-01

    Full Text Available Facial expressions analysis is applicable in various vision systems, new interfaces for television and other entertainment systems, diagnosis and monitoring of deceases, speech processing, modern smart digital cameras and perceptual man-machine interfaces etc. Smile is human’s expression for happiness. Detection of smile by a machine is helpful to establish human machine interaction in many situations. Many researchers worked on facial expression recognition, but there is not much research about smile detection. In this paper we proposed a simple image-based approach to identify the smile.

  10. Nonlinear evolution equations kinetic approach

    CERN Document Server

    Maslova, Nina

    1993-01-01

    The book is devoted to the questions of the long-time behavior of solutions for evolution equations, connected with kinetic models in statistical physics. There is a wide variety of problems where such models are used to obtain reasonable physical as well as numerical results (Fluid Mechanics, Gas Dynamics, Plasma Physics, Nuclear Physics, Turbulence Theory etc.). The classical examples provide the nonlinear Boltzmann equation. Investigation of the long-time behavior of the solutions for the Boltzmann equation gives an approach to the nonlinear fluid dynamic equations. From the viewpoint of dy

  11. PRE - SIGMOID SINUS APPROACH TO PETROCLIVAL MENINGIOMA

    Directory of Open Access Journals (Sweden)

    S.E. Ketabchi A. Taghikhani

    1999-07-01

    Full Text Available In this article, the prcsigrnoid avenue to pertroclivai region is introduced and the advantage of such an approach is disusscd. Ten patients were operated on by this approach. Two illustrative cases are also presented.

  12. The 'Whole Diet' Approach to Nutrition

    Science.gov (United States)

    ... Diet_022315.html The 'Whole Diet' Approach to Nutrition HealthDay News Video - February 23, 2015 To use ... JavaScript. Play video: The 'Whole Diet' Approach to Nutrition For closed captioning, click the CC button on ...

  13. An Effective Approach to Teaching Electrochemistry.

    Science.gov (United States)

    Birss, Viola I.; Truax, D. Rodney

    1990-01-01

    An approach which may be useful for teaching electrochemistry in freshman college chemistry courses is presented. Discussed are the potential problems with teaching this subject and solutions provided by this approach. (CW)

  14. A systems approach to traditional oriental medicine

    DEFF Research Database (Denmark)

    Kim, Hyun Uk; Ryu, Jae Yong

    2015-01-01

    Analyzing structural similarities between compounds derived from traditional oriental medicine and human metabolites is a systems-based approach that can help identify mechanisms of action and suggest approaches to reduce toxicity.

  15. 49 CFR 236.760 - Locking, approach.

    Science.gov (United States)

    2010-10-01

    ...Transportation 4 2010-10-01 2010-10-01 false Locking, approach. 236.760 Section 236.760 Transportation Other...DEVICES, AND APPLIANCES Definitions § 236.760 Locking, approach. Electric locking effective while a train is...

  16. Support for Quitting: Choose Your Approach

    Science.gov (United States)

    ... not to display inline frames. Home > Choose your approach This section will be most useful for people ... to quit without some support. Several proven treatment approaches are available. One size doesn't fit all, ...

  17. The Team Approach to Pain Relief

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues The Team Approach to Pain Relief Past Issues / Fall 2007 Table ... is an example of a relatively new team approach to pain treatment, especially for cases of chronic ...

  18. Quantitative Approaches to Semantic Knowledge Representations.

    Science.gov (United States)

    Foltz, Peter W.

    1998-01-01

    Introduces this special issue which describes several approaches to semantic knowledge representations. Discusses the various quantitative procedures employed in the articles, noting that they can also serve as theoretical approaches to knowledge representation. (SR)

  19. Forearm Approach for Percutaneous Coronary Procedures

    OpenAIRE

    Stajic, Zoran; Romanovic, Radoslav; Tavciovski, Dragan

    2013-01-01

    This article gives contemporary review on the forearm approach for percutaneous diagnostic and interventional coronary procedures. Advantages and disadvantages as well as practical issues and current controversies regarding both radial and ulnar artery approach are discussed throughout the paper. Having in mind advantages of forearm approach in terms of safety and comfort over the traditional femoral approach, as well as the rapid development of invasive technology in the past years, it will ...

  20. Speech Recognition Using Stochastic Approach: A Review

    OpenAIRE

    RANU DIXIT; NAVDEEP KAUR,

    2013-01-01

    In today’s world, Speech Recognition is very important and popular. Automatic Speech Recognition System consists of three phases: Preprocessing, Feature Extraction and Recognition. Speech recognition is the process of converting spoken words into text. In case of speech recognition the research followers are mainly using three different approaches namely Acoustic phonetic approach, Pattern recognition approach and Artificial intelligence approach. The main goal of this paper is to discuss t...

  1. Subcranial Approach in Pediatric Craniofacial Surgery

    OpenAIRE

    Ciechomski, Jorge; Aufgang, Ruben; Villanueva, Lucrecia; Demarchi, Victoria

    2010-01-01

    We report our experience with the subcranial approach, developed at the Plastic Surgery Unit of Hospital “Ricardo Gutiérrez,” for the treatment of injuries in the frontoethmoidal orbital region in pediatric patients. The subcranial approach was described by Raveh et al for the treatment of fractures in the frontoethmoidal area. The subcranial approach was used later for surgery of tumors and deformities of the frontoethmoidal region. We have used this approach in nine cases of nontraumat...

  2. Biliary lithiasis approach in open laparoscopy

    International Nuclear Information System (INIS)

    Laparoscopic approach is currently the elective approach in the treatment of non complicated biliary lithiasis.There was a time when an umbilical herniation presented a series of problems at the time of deciding on the approach to be taken.The paper refers to 2 cases of laparoscopic approach in the treatment of symptomatised biliary lithiasis, with an open laparoscopy technique through umbilical hernia ton ring.The repair of herniation was performed in the same operative act with good immediate results

  3. DOE systems approach and integration

    International Nuclear Information System (INIS)

    Six sites are now disposing of most of DOE's currently generated waste. These are: Hanford, Idaho National Engineering Laboratory, Los Alamos National Laboratory, the Nevada Test Site, Oak Ridge, and Savannah River. Within DOE, experience with disposal of solid LLW has been that arid site disposal facilities (first four) appear to have performed well, while humid site disposal facilities (last two) have experienced some waste migration. DOE's intent, of course, is to operate all its waste disposal facilities so that public health and safety are not adversely affected. To ensure that this continues to be the case, activities are underway to increase use of waste form stabilization and engineered barriers where appropriate. For the sake of overall economy, these measures are to be applied as and where needed, through use of the systems approach. In this paper the author discusses two topics: the system approach, which DOE has decided to use for resolving waste disposal problems in the management of DOE's low-level wastes; and DOE's intended integration of activities underway at the waste management systems throughout DOE facilities. 2 figures

  4. Environmental education and indigenous approach

    International Nuclear Information System (INIS)

    Environmental pollution control is the most important and highly discussed issue at the international level. Our and our's next generation survival highly depends on environment. Environmental security is not less important than territorial security. Living in the Competitive trade, Business and Commerce era. WTO threats of globalization to countries like Pakistan require sharp and immediate actions. SOS(Save our Sole) steps should be taken in Environmental Education in order to reorganizing values and clarifying Concepts to develop the necessary skills and attitude necessary to understand and appreciate the interrelatidness among masses, the Cultures and Ecosystem. Historical backgrounds along with different approaches were discussed particularly reference to Pakistan. In this presentation a new but indigenous idea is flashed to improve the environment education system in poor third world countries including Pakistan. Instead of imported ideas, previous implemented as such, indigenous approach highly Perfumed with Islamic, Ideological and cultural blends will do the right job in right direction if employed with true sense of commitment. (author)

  5. Network Approach and Stakeholder Management

    Directory of Open Access Journals (Sweden)

    Mauro Sciarelli

    2013-04-01

    Full Text Available Recent economic crises show that enterprises cannot be managed focusing only on economic values instead managers should acknowledge their own enterprises' responsibilities toward the society as a whole. Stakeholder Management Theory can help managers accomplishing this very same daunting task. This theory demands managers to reckon the reciprocal influences linking other social actors to the enterprise activities and to understand the relative effects. While most of the works in this theory has been geared towards defining, identifying and managing each single dyadic relationship some other scholar have highlighted the need to focus on the stakeholder network to correctly assess each stakeholder's role and to fully grasp the long term effects enterprise's action will have. In this paper after a review of the main topics in stakeholder management theory, we classify the various approach to Stakeholder Management Theory to identify relevant theoretical contributions and to highlight how the theoretical gap can be crossed using the tools of Social Network Analysis and embracing the network approach to stakeholder management.

  6. Transradial approach for coronary interventions

    Scientific Electronic Library Online (English)

    José Carlos, Brito; Antônio, Azevedo Júnior; Adriano, Oliveira; Roberto, Von Sohsten; Ademar, Santos Filho; Heitor, Carvalho.

    2001-05-01

    Full Text Available OBJECTIVE: To assess the feasibility and safety of coronary interventions performed through the radial artery. METHODS: We studied 103 patients with ages from 38 to 86 years (57±8.7), 90 (87%) males, and: radial pulse with a good amplitude, presence of ulnar pulse, a good collateral flow through the [...] palmar arch assessed with the Allen's test. RESULTS: The vascular approach was obtained in 97 (94%) patients, 88 (91%) treated electively and 9 (9%) during acute myocardial infarction, for primary angioplasty; 56 (64%) unstable angina; 22 (25%) stable angina; 10 (11%) were asymptomatic, 6 referred for recanalization of chronic occlusion and 4 silent ischemia in the first week after acute myocardial infarction. We approached 107 arteries: anterior descending artery, 49 (46%); right coronary artery, 27 (25%); circumflex artery, 25 (23%); diagonal artery, 6 (6%); and 2 saphenous vein bypass grafts. We treated 129 lesions: 80 (62%) B2 type; 23 (18%) B1 type; 17 (13%) C type; and 9 (7%). A type. There were 70 stents , and 59 balloon angioplasties performed. Thirty-two (33%) patients used GP IIb/IIIa inhibitors. The mean duration of the elective procedure was 42.3±12.8 min. Success, correct stent deployment and residual lesion

  7. Interdisciplinary Approach in Engineering Education

    Directory of Open Access Journals (Sweden)

    Anda Zeidmane

    2011-04-01

    Full Text Available The analysis of the scientific literature available on the types of general competences and their classification caused the authors to conclude that it is necessary to implement interdisciplinary approach in engineering education to develop competences necessary for engineers to make them competitive in the labour market. The attention should be paid to a professional foreign language, computer literacy and educational psychology recommendations. To improve professional foreign language skills, CLIL (Content and Language Integrated Learning method should be integrated in the study process of engineering education. In order to develop information literacy competence, it is important to create a single e-study environment. The academic staff, developing study subjects for engineering programmes, should focus on the study content and study methods. As regards the content, the compromise should be sought between fundamental acquisition of the knowledge of the subject matter, the know-how of the application of this knowledge as well as the use of brand new software in the calculations. The paper presents the examples of the application of the interdisciplinary approach in the universities, where the authors of the paper are affiliated: the LUA (Latvia University of Agriculture and the RTU (Riga Technical University, respectively.

  8. Fast approach for toner saving

    Science.gov (United States)

    Safonov, Ilia V.; Kurilin, Ilya V.; Rychagov, Michael N.; Lee, Hokeun; Kim, Sangho; Choi, Donchul

    2011-01-01

    Reducing toner consumption is an important task in modern printing devices and has a significant positive ecological impact. Existing toner saving approaches have two main drawbacks: appearance of hardcopy in toner saving mode is worse in comparison with normal mode; processing of whole rendered page bitmap requires significant computational costs. We propose to add small holes of various shapes and sizes to random places inside a character bitmap stored in font cache. Such random perforation scheme is based on processing pipeline in RIP of standard printer languages Postscript and PCL. Processing of text characters only, and moreover, processing of each character for given font and size alone, is an extremely fast procedure. The approach does not deteriorate halftoned bitmap and business graphics and provide toner saving for typical office documents up to 15-20%. Rate of toner saving is adjustable. Alteration of resulted characters' appearance is almost indistinguishable in comparison with solid black text due to random placement of small holes inside the character regions. The suggested method automatically skips small fonts to preserve its quality. Readability of text processed by proposed method is fine. OCR programs process that scanned hardcopy successfully too.

  9. Systematic approach to thermal leptogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Frossard, T.; Kartavtsev, A. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Garny, M. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Hohenegger, A. [Ecole Polytechnique Federale de Lausanne, LPPC, BSP (Switzerland); Mitrouskas, D. [Muenchen Univ. (Germany)

    2012-11-15

    In this work we study thermal leptogenesis using non-equilibrium quantum field theory. Starting from fundamental equations for correlators of the quantum fields we describe the steps necessary to obtain quantum kinetic equations for quasiparticles. These can easily be compared to conventional results and overcome conceptional problems inherent in the canonical approach. Beyond CP-violating decays we include also those scattering processes which are tightly related to the decays in a consistent approximation of fourth order in the Yukawa couplings. It is demonstrated explicitly how the S-matrix elements for the scattering processes in the conventional approach are related to two- and three-loop contributions to the effective action. We derive effective decay and scattering amplitudes taking medium corrections and thermal masses into account. In this context we also investigate CP-violating Higgs decay within the same formalism. From the kinetic equations we derive rate equations for the lepton asymmetry improved in that they include quantum-statistical effects and medium corrections to the quasiparticle properties.

  10. Bionanoparticles, a green nanochemistry approach

    Scientific Electronic Library Online (English)

    Ana, Cauerhff; Guillermo R, Castro.

    2013-05-15

    Full Text Available Background: In the past decade, considerable attention has been paid for the development of novel strategies for the synthesis of different kind of nano-objects. Most of the current strategies are usually working by the use physical or chemical principles to develop a myriad of nano-objects with mul [...] tiple applications. Main fields of nanotechnology applications range from catalysis, micro- and nano-electronics (semiconductors, single electrons transistors), non-linear optic devices, photo-electrochemistry to biomedicine, diagnostics, foods and environment, chemical analysis and others. Results: Two main avenues for nanoparticles synthesis: cell-free extract and cell cultivation have been reported. The state of art of both biotechnological approaches for different type nanoparticles are reviewed in this work. Conclusions: Nanotechnology is a revolutionary field just at its onset, the trend in the next decades being its integration with the green chemistry approach. Several strategies involving exhaustive strain selection, cultivation modes, recombinant gene expression, metabolic engineering, protein re-design and re-engineering, and predictive modeling will allow to create nanobioreactors, a new nanobiotechnology arena with a high potential impact in many fields.

  11. Cardiac imaging. A multimodality approach

    International Nuclear Information System (INIS)

    An excellent atlas on modern diagnostic imaging of the heart Written by an interdisciplinary team of experts, Cardiac Imaging: A Multimodality Approach features an in-depth introduction to all current imaging modalities for the diagnostic assessment of the heart as well as a clinical overview of cardiac diseases and main indications for cardiac imaging. With a particular emphasis on CT and MRI, the first part of the atlas also covers conventional radiography, echocardiography, angiography and nuclear medicine imaging. Leading specialists demonstrate the latest advances in the field, and compare the strengths and weaknesses of each modality. The book's second part features clinical chapters on heart defects, endocarditis, coronary heart disease, cardiomyopathies, myocarditis, cardiac tumors, pericardial diseases, pulmonary vascular diseases, and diseases of the thoracic aorta. The authors address anatomy, pathophysiology, and clinical features, and evaluate the various diagnostic options. Key features: - Highly regarded experts in cardiology and radiology off er image-based teaching of the latest techniques - Readers learn how to decide which modality to use for which indication - Visually highlighted tables and essential points allow for easy navigation through the text - More than 600 outstanding images show up-to-date technology and current imaging protocols Cardiac Imaging: A Multimodality Approach is a must-have desk reference for cardiologists and radiologists inence for cardiologists and radiologists in practice, as well as a study guide for residents in both fields. It will also appeal to cardiac surgeons, general practitioners, and medical physicists with a special interest in imaging of the heart. (orig.)

  12. Systematic approach to thermal leptogenesis

    International Nuclear Information System (INIS)

    In this work we study thermal leptogenesis using non-equilibrium quantum field theory. Starting from fundamental equations for correlators of the quantum fields we describe the steps necessary to obtain quantum kinetic equations for quasiparticles. These can easily be compared to conventional results and overcome conceptional problems inherent in the canonical approach. Beyond CP-violating decays we include also those scattering processes which are tightly related to the decays in a consistent approximation of fourth order in the Yukawa couplings. It is demonstrated explicitly how the S-matrix elements for the scattering processes in the conventional approach are related to two- and three-loop contributions to the effective action. We derive effective decay and scattering amplitudes taking medium corrections and thermal masses into account. In this context we also investigate CP-violating Higgs decay within the same formalism. From the kinetic equations we derive rate equations for the lepton asymmetry improved in that they include quantum-statistical effects and medium corrections to the quasiparticle properties.

  13. Multidisciplinary approaches to solar hydrogen.

    Science.gov (United States)

    Bren, Kara L

    2015-06-01

    This review summarizes three different approaches to engineering systems for the solar-driven evolution of hydrogen fuel from water: molecular, nanomaterials and biomolecular. Molecular systems have the advantage of being highly amenable to modification and detailed study and have provided great insight into photophysics, electron transfer and catalytic mechanism. However, they tend to display poor stability. Systems based on nanomaterials are more robust but also are more difficult to synthesize in a controlled manner and to modify and study in detail. Biomolecular systems share many properties with molecular systems and have the advantage of displaying inherently high efficiencies for light absorption, electron-hole separation and catalysis. However, biological systems must be engineered to couple modules that capture and convert solar photons to modules that produce hydrogen fuel. Furthermore, biological systems are prone to degradation when employed in vitro. Advances that use combinations of these three tactics also are described. Multidisciplinary approaches to this problem allow scientists to take advantage of the best features of biological, molecular and nanomaterials systems provided that the components can be coupled for efficient function. PMID:26052425

  14. A Novel Approach for Identifying Intruder based on Multiple Approaches

    Directory of Open Access Journals (Sweden)

    Amit Kumar Sharma

    2010-12-01

    Full Text Available The paper reviews of research to identify the intrusion and intruder, most computers authenticate user ID and password before users can login these systems. However, danger soon comes if the two items are known to hackers. In this paper, we propose a system that finds who intrude and how they intrude in to the system. The information about the intruder and their saved information in the data warehouse to the other location without knowing to the intruder and in this duration server will find the information about the intruder. In future when intruder again enter in the network then caught and show the information about him and last time you enter in this network. For this technique I can reduce the network attack. And find more type of Network intrusion Detecting System with using data mining Approach. Our experimental results show that the recognition accuracy of students of computer science department is up to 99%.

  15. Nonlinear approaches in engineering applications 2

    CERN Document Server

    Jazar, Reza N

    2013-01-01

    Provides updated principles and applications of the nonlinear approaches in solving engineering and physics problems Demonstrates how nonlinear approaches may open avenues to better, safer, cheaper systems with less energy consumption Has a strong emphasis on the application, physical meaning, and methodologies of nonlinear approaches in different engineering and science problems

  16. A Nonviolent Approach to Social Justice Education

    Science.gov (United States)

    Wang, Hongyu

    2013-01-01

    This article advocates a nonviolent approach to social justice education. First, social justice education literature is reviewed, and two contrasting and influential approaches--critical theory and poststructural theory--are the focus of critical analysis. A nonviolent approach is proposed as an alternative. Second, the notion of social justice is…

  17. A Quantum Information Retrieval Approach to Memory

    OpenAIRE

    Kitto, Kirsty; Bruza, Peter; Gabora, Liane

    2013-01-01

    As computers approach the physical limits of information storable in memory, new methods will be needed to further improve information storage and retrieval. We propose a quantum inspired vector based approach, which offers a contextually dependent mapping from the subsymbolic to the symbolic representations of information. If implemented computationally, this approach would provide exceptionally high density of information storage, without the traditionally required physica...

  18. 49 CFR 236.803 - Signal, approach.

    Science.gov (United States)

    2010-10-01

    ...2010-10-01 2010-10-01 false Signal, approach. 236.803 Section 236.803 Transportation...APPLIANCES Definitions § 236.803 Signal, approach. A roadway signal used to govern the approach to another signal and if operative so...

  19. 10 CFR 830.7 - Graded approach.

    Science.gov (United States)

    2010-01-01

    ...2010-01-01 2010-01-01 false Graded approach. 830.7 Section 830.7 Energy...SAFETY MANAGEMENT § 830.7 Graded approach. Where appropriate, a contractor must use a graded approach to implement the requirements of...

  20. Pure extradural approach for skull base lesions.

    Directory of Open Access Journals (Sweden)

    Gupta S

    1999-10-01

    Full Text Available Lesions in the parasellar and paracavernous regions can be removed by various skull base approaches involving basal osteotomies. A major complication of intradural skull base approaches is CSF leak and associated meningitis. We have managed 5 patients with skull base lesions with a pure extradural approach using wide basal osteotomies. The operative techniques are described.

  1. Materiality in a Practice-Based Approach

    Science.gov (United States)

    Svabo, Connie

    2009-01-01

    Purpose: The paper aims to provide an overview of the vocabulary for materiality which is used by practice-based approaches to organizational knowing. Design/methodology/approach: The overview is theoretically generated and is based on the anthology Knowing in Organizations: A Practice-based Approach edited by Nicolini, Gherardi and Yanow. The…

  2. Towards a corporate approach for energy efficiency

    International Nuclear Information System (INIS)

    The corporate approach is a well-known an much discussed subject. At present the corporate approach is not a legal possibility in the Netherlands. A study has been carried out to investigate the consequences of a corporate approach on the energy efficiency in departments of Philips Nederland

  3. Oblique transsphenoethmoidal approach to the cavernous sinus.

    Science.gov (United States)

    Gnjidi?, Zivko; Sajko, Tomislav; Malenica, Masa; Kudeli?, Nenad; Talan-Hranilovi?, Jasna; Rumboldt, Zoran

    2008-10-01

    Pituitary adenomas frequently invade the cavernous sinus. The standard transsphenoidal approach does not provide satisfactory visualization of the cavernous sinus structures. The transcranial approach has no advantages, and increases the operative trauma and complications. The oblique transsphenoethmoidal approach, a modified standard transsphenoidal approach, was used to treat 19 patients with pituitary adenomas invading the cavernous sinus. Complete tumor removal was achieved in 15 patients and subtotal removal in 4 patients. The patients tolerated this modified transsphenoethmoidal approach well and the postoperative results were satisfactory. Although the number of patients was too small to allow any statistical analysis, the results, compared with other series, are encouraging. PMID:18948676

  4. Medical biofilms--nanotechnology approaches.

    Science.gov (United States)

    Neethirajan, Suresh; Clond, Morgan A; Vogt, Adam

    2014-10-01

    Biofilms are colonies of bacteria or fungi that adhere to a surface, protected by an extracellular polymer matrix composed of polysaccharides and extracellular DNA. They are highly complex and dynamic multicellular structures that resist traditional means of killing planktonic bacteria. Recent developments in nanotechnology provide novel approaches to preventing and dispersing biofilm infections, which are a leading cause of morbidity and mortality. Medical device infections are responsible for approximately 60% of hospital acquired infections. In the United States, the estimated cost of caring for healthcare-associated infections is approximately between $28 billion and $45 billion per year. In this review, we will discuss our current understanding of biofilm formation and degradation, its relevance to challenges in clinical practice, and new technological developments in nanotechnology that are designed to address these challenges. PMID:25992419

  5. Diffraction operators in paraxial approach

    Science.gov (United States)

    Lasso, William; Navas, Marianela; Añez, Liz; Urdaneta, Romer; Díaz, Leonardo; Torres, César O.

    2014-07-01

    Nowadays, research in the field of science education points to the creation of alternative ways of teaching contents encouraging the development of more elaborate reasoning, where a high degree of abstraction and generalization of scientific knowledge prevails. On that subject, this research shows a didactic alternative proposal for the construction of Fresnel and Fraunhoffer diffraction concepts applying the Fourier transform technique in the study of electromagnetic waves propagation in free space. Curvature transparency and Fourier sphere operators in paraxial approximation are used in order to make the usual laborious mathematical approach easier. The main result shows that the composition of optic metaxial operators results in the discovery of a simpler way out of the standard electromagnetic wave propagation in free space between a transmitter and a receptor separated from a given distance. This allows to state that the didactic proposal shown encourages the construction of Fresnel and Fraunhoffer diffraction concepts in a more effective and easier way than the traditional teaching.

  6. A stochastic approach to microphysics

    International Nuclear Information System (INIS)

    The presently widespread idea of ''vacuum population'', together with the quantum concept of vacuum fluctuations leads to assume a random level below that of matter. This stochastic approach starts by a reminder of the author's previous work, first on the relation of diffusion laws with the foundations of microphysics, and then on hadron spectrum. Following the latter, a random quark model is advanced; it gives to quark pairs properties similar to those of a harmonic oscillator or an elastic string, imagined as an explanation to their asymptotic freedom and their confinement. The stochastic study of such interactions as electron-nucleon, jets in e+e- collisions, or pp ? ?0 + X, gives form factors closely consistent with experiment. The conclusion is an epistemological comment (complementarity between stochastic and quantum domains, E.P.R. paradox, etc...)

  7. Computational approach to Riemann surfaces

    CERN Document Server

    Klein, Christian

    2011-01-01

    This volume offers a well-structured overview of existent computational approaches to Riemann surfaces and those currently in development. The authors of the contributions represent the groups providing publically available numerical codes in this field. Thus this volume illustrates which software tools are available and how they can be used in practice. In addition examples for solutions to partial differential equations and in surface theory are presented. The intended audience of this book is twofold. It can be used as a textbook for a graduate course in numerics of Riemann surfaces, in which case the standard undergraduate background, i.e., calculus and linear algebra, is required. In particular, no knowledge of the theory of Riemann surfaces is expected; the necessary background in this theory is contained in the Introduction chapter. At the same time, this book is also intended for specialists in geometry and mathematical physics applying the theory of Riemann surfaces in their research. It is the first...

  8. A programming approach to computability

    CERN Document Server

    Kfoury, A J; Arbib, Michael A

    1982-01-01

    Computability theory is at the heart of theoretical computer science. Yet, ironically, many of its basic results were discovered by mathematical logicians prior to the development of the first stored-program computer. As a result, many texts on computability theory strike today's computer science students as far removed from their concerns. To remedy this, we base our approach to computability on the language of while-programs, a lean subset of PASCAL, and postpone consideration of such classic models as Turing machines, string-rewriting systems, and p. -recursive functions till the final chapter. Moreover, we balance the presentation of un solvability results such as the unsolvability of the Halting Problem with a presentation of the positive results of modern programming methodology, including the use of proof rules, and the denotational semantics of programs. Computer science seeks to provide a scientific basis for the study of information processing, the solution of problems by algorithms, and the design ...

  9. Experimental design a chemometric approach

    CERN Document Server

    Deming, SN

    1987-01-01

    Now available in a paperback edition is a book which has been described as ``...an exceptionally lucid, easy-to-read presentation... would be an excellent addition to the collection of every analytical chemist. I recommend it with great enthusiasm.'''' (Analytical Chemistry). Unlike most current textbooks, it approaches experimental design from the point of view of the experimenter, rather than that of the statistician. As the reviewer in `Analytical Chemistry'' went on to say: ``Deming and Morgan should be given high praise for bringing the principles of experimental design to the level of the practicing analytical chemist.''''.The book first introduces the reader to the fundamentals of experimental design. Systems theory, response surface concepts, and basic statistics serve as a basis for the further development of matrix least squares and hypothesis testing. The effects of different experimental designs and different models on the variance-covariance matrix and on the analysis of variance (ANOVA) are exte...

  10. Approaches to resolving trade disputes.

    Science.gov (United States)

    Wilson, D W; Thiermann, A B

    2003-08-01

    The authors discuss the various approaches to resolving trade disputes available to Member Countries of the OIE (World organisation for animal health). The paper first describes the rights and obligations of Member Countries in setting health measures for the importation of animals and animal products, according to the provisions of the World Trade Organization (WTO) Agreement on the Application of Sanitary and Phytosanitary Measures (the SPS Agreement). The authors indicate how OIE standards may be used to set import measures and introduce issues such as equivalence and the use of provisional measures, which are both areas of potential conflict. The authors then describe the options available for resolving disputes--bilateral discussions, mediation through the OIE, the use of the WTO SPS Committee and the formal WTO dispute settlement process, discussing the advantages and disadvantages of each. PMID:15884603

  11. Immunotherapeutic approaches for Alzheimer's disease.

    Science.gov (United States)

    Wisniewski, Thomas; Goñi, Fernando

    2015-03-18

    Alzheimer's disease (AD) is the most prevalent form of dementia worldwide and is an emerging global epidemic. It is characterized by an imbalance between production and clearance of amyloid ? (A?) and tau proteins. Oligomeric forms of A? and tau are believed to be the most toxic. Dramatic results from AD animal models showed great promise for active and passive immune therapies targeting A?. However, there is very limited evidence in human studies of the clinical benefits from these approaches. Immunotherapies targeting only tau pathology have had some success but are limited so far to mouse models. The majority of current methods is based on immunological targeting of a self-protein; hence, benefits need to be balanced against risks of stimulating excessive autoimmune toxic inflammation. For greater efficacy the next generation of vaccines needs to focus more on concurrently targeting all the intermediate toxic conformers of oligomeric A? and tau species. PMID:25789753

  12. A New Approach for FCSRs

    Science.gov (United States)

    Arnault, Francçois; Berger, Thierry; Lauradoux, Cédric; Minier, Marine; Pousse, Benjamin

    The Feedback with Carry Shift Registers (FCSRs) have been proposed as an alternative to Linear Feedback Shift Registers (LFSRs) for the design of stream ciphers. FCSRs have good statistical properties and they provide a built-in non-linearity. However, two attacks have shown that the current representations of FCSRs can introduce weaknesses in the cipher. We propose a new “ring” representation of FCSRs based upon matrix definition which generalizes the Galois and Fibonacci representations. Our approach preserves the statistical properties and circumvents the weaknesses of the Fibonacci and Galois representations. Moreover, the ring representation leads to automata with a quicker diffusion characteristic and better implementation results. As an application, we describe a new version of F-FCSR stream ciphers.

  13. Synthetic approaches to multifunctional indenes

    Directory of Open Access Journals (Sweden)

    Neus Mesquida

    2011-12-01

    Full Text Available The synthesis of multifunctional indenes with at least two different functional groups has not yet been extensively explored. Among the plausible synthetic routes to 3,5-disubstituted indenes bearing two different functional groups, such as the [3-(aminoethylinden-5-yl]amines, a reasonable pathway involves the (5-nitro-3-indenylacetamides as key intermediates. Although several multistep synthetic approaches can be applied to obtain these advanced intermediates, we describe herein their preparation by an aldol-type reaction between 5-nitroindan-1-ones and the lithium salt of N,N-disubstituted acetamides, followed immediately by dehydration with acid. This classical condensation process, which is neither simple nor trivial despite its apparent directness, permits an efficient entry to a variety of indene-based molecular modules, which could be adapted to a range of functionalized indanones.

  14. Autobot Evolution: A Futuristic approach

    Directory of Open Access Journals (Sweden)

    N.Hariharan#

    2011-06-01

    Full Text Available SCABOR is an approach for the 3-D lane detection and autonomous driving. Its main attribute is to diagnose the metrology of roads. It has a wide significance in determining the basic structure, the presence of humps and dips and gives a clear and cache information of the way .Our view on this paper is to apply SCABOR along with the application of the GLOBAL POSITIONING SYSTEM in autonomous driving system for safe and fast driving. Here the SCABOR technology’s currentapplication is outlined and its use has been extended to traffic system. We have suggested a unique method for flexible driving. We also suggest ways in which SCABOR technology can be enhanced forfuture applications. Among the significant advantages, these techniques perform well even in high risk zones and congested areas with up to 100% accuracy where many other techniques fail.

  15. RBE from a microdosimetric approach

    International Nuclear Information System (INIS)

    This report reviews the current status of microdosimetry and knowledge regarding the response of biological systems to radiation fields of differing linear energy transfer (LET). The primary objective is to investigate the potential application to radon daughter lung dosimetry. The concept of track structure and its statistical behaviour is discussed and applied to estimate the yield of double strand breaks (DSBs). The general microdosimetric approach to modelling radiation response is presented in terms of the hit-size effectiveness function and the behaviour for specific proposed functions is examined. Radiobiological investigations of the DSB, chromosome aberration and oncogenic transformation end points are reviewed with emphasis on recent developments. A simplified model system is developed illustrating the potential for analysis of the risk from radon daughter inhalation and published research directed towards this goal is discussed. (author). 66 refs., 3 tabs., 17 figs

  16. Termination Analysis Approach and Implementation

    Directory of Open Access Journals (Sweden)

    L. Baba-hamed

    2006-01-01

    Full Text Available An active database system is a system which provides the same functionalities as a classic database system and is, equally, capable to react, automatically, to state changes by means of rules said active rules. The triggering of these rules can produce an infinite cycle and leads to the no termination problem. In this study, we propose a method of termination analysis of active rules based on Petri nets (PN and give an object oriented representation to implement it. This approach is better than the previous ones because it takes into a count composite events and the rule priority on the one hand and both rule representation and rule analysis are performed in the same PN on the other hand.

  17. Elliptic curves a computational approach

    CERN Document Server

    Schmitt, Susanne; Pethö, Attila

    2003-01-01

    The basics of the theory of elliptic curves should be known to everybody, be he (or she) a mathematician or a computer scientist. Especially everybody concerned with cryptography should know the elements of this theory. The purpose of the present textbook is to give an elementary introduction to elliptic curves. Since this branch of number theory is particularly accessible to computer-assisted calculations, the authors make use of it by approaching the theory under a computational point of view. Specifically, the computer-algebra package SIMATH can be applied on several occasions. However, the book can be read also by those not interested in any computations. Of course, the theory of elliptic curves is very comprehensive and becomes correspondingly sophisticated. That is why the authors made a choice of the topics treated. Topics covered include the determination of torsion groups, computations regarding the Mordell-Weil group, height calculations, S-integral points. The contents is kept as elementary as poss...

  18. Percutaneous approach and transseptal catheterization

    International Nuclear Information System (INIS)

    In contrast, with the direct brachial technique, the percutaneous approach to left and right heart catheterizaiton involves achieving vascular access via needle puncture, obviating surgical isolation of the vessel during either the introduction or subsequent withdrawal of the cardiac catheter. With appropriate skill and knowledge of regional anatomy, the percutaneous technique can be adapted to catheter insertion from a variety of entry sites. Venous catheterization can be performed via the femoral, internal jugular, subclavian, or median antecubital vein, whereas arterial catheterization can be performed via the femoral, brachial, or axillary artery. At the termination of the procedure, the catheters and introducing sheaths are withdrawn, and bleeding from the puncture sites is controlled by the application of direct pressure

  19. Pharmacotherapy of Schizophrenia: Ploypharmacy Approaches

    Directory of Open Access Journals (Sweden)

    Fatemeh Rahiminejad

    2010-07-01

    Full Text Available "nSchizophrenia is a debilitating illness, rating as one of the leading causes of lost years of quality of life. The illness imposes a disproportionate burden on patients and their families, healthcare systems and society. Pharmacological management is the cornerstone of treatment of schizophrenia, and antipsychotics, both first generation of antipsychotics and second generation of antipsychotics, are efficacious in reducing levels of psychopathology in acute episodes of schizophrenia. Clearly a need for innovative treatment strategies in schizophrenia that will ensure increased effectiveness against negative symptoms and cognitive dysfunction dysfunction. Therefore, in majority of cases polypharmacy is one of the effective approaches. This review focused on polypharmacy in the treatment of schizophrenia and in particular negative symptoms.

  20. Entropy: The Markov Ordering Approach

    Directory of Open Access Journals (Sweden)

    Alexander N. Gorban

    2010-05-01

    Full Text Available The focus of this article is on entropy and Markov processes. We study the properties of functionals which are invariant with respect to monotonic transformations and analyze two invariant “additivity” properties: (i existence of a monotonic transformation which makes the functional additive with respect to the joining of independent systems and (ii existence of a monotonic transformation which makes the functional additive with respect to the partitioning of the space of states. All Lyapunov functionals for Markov chains which have properties (i and (ii are derived. We describe the most general ordering of the distribution space, with respect to which all continuous-time Markov processes are monotonic (the Markov order. The solution differs significantly from the ordering given by the inequality of entropy growth. For inference, this approach results in a convex compact set of conditionally “most random” distributions.

  1. Henipavirus pathogenesis and antiviral approaches.

    Science.gov (United States)

    Mathieu, Cyrille; Horvat, Branka

    2015-03-01

    Hendra virus and Nipah virus are closely related, recently emerged zoonotic paramyxoviruses, belonging to the Henipavirus genus. Both viruses induce generalized vasculitis affecting particularly the respiratory tract and CNS. The exceptionally broad species tropism of Henipavirus, the high case fatality rate and person-to-person transmission associated with Nipah virus outbreaks emphasize the necessity of effective antiviral strategies for these intriguing threatening pathogens. Current therapeutic approaches, validated in animal models, target early steps in viral infection; they include the use of neutralizing virus-specific antibodies and blocking membrane fusion with peptides that bind the viral fusion protein. A better understanding of Henipavirus pathogenesis is critical for the further advancement of antiviral treatment, and we summarize here the recent progress in the field. PMID:25634624

  2. The thermodynamic approach to market

    CERN Document Server

    Sergeev, Victor

    2008-01-01

    The first (Russian) edition of the book was among the first monographs on econophysics. The book gives an explanation of several intriguing phenomena, providing new insights and answers to some deeply vexing questions. Why the economic "shock therapy" implemented in Eastern Europe was doomed to a failure whereas the approach adopted by China and Vietnam should inevitably lead to economic growth (damped, perhaps, by corruption and inconsistencies)? Why some restrictions imposed on markets are dangerous? Politicians (and laymen) usually believe that the more restrictions you impose on the society, the easier it is to govern. The reality seems to be more subtle. Some restrictions are necessary for the markets to function. However, restrictions on salary, for example, seem to always result in unemployment, as a simple "spin" model shows. Evidently, optimizing freedom is an equilibrium problem, and none of the extrema is devoid of danger. Why should crooked dealings be prevented? What is a reasonable rate of taxat...

  3. An Experimental Approach to Starshades

    Science.gov (United States)

    Samuele, Rocco; Varshneya, R.; Glassman, T.; Johnson, A. M. F.; Shipley, A.

    2010-01-01

    A starshade is an external occulter that flies tens of thousands of kilometers in front of a space telescope, along the line-of-sight to a star. A starshade blocks starlight before it enters the telescope, mitigating diffraction, and making Earth-like planets observable. The starshade testbed at Northrop Grumman Aerospace Systems (NGAS) is capable of testing the performance of sub-scale starshades in mission-similar configurations. Thus far at NGAS, starshades have suppressed a simulated star to the 10-7 contrast level or better across a broad white light bandpass. The goal of the testbed has been deep starlight suppression, but it is also important to understand starshade sensitivity to shape deformations. The purpose of this poster is to summarize our approach and initial results of assessing the impact of starshade shape flaws on performance using the testbed. We are working toward a convergence of experimental results and theoretical predictions.

  4. Steganography and Steganalysis: Different Approaches

    CERN Document Server

    Das, Soumyendu; Bandyopadhyay, Bijoy; Sanyal, Sugata

    2011-01-01

    Steganography is the technique of hiding confidential information within any media. Steganography is often confused with cryptography because the two are similar in the way that they both are used to protect confidential information. The difference between the two is in the appearance in the processed output; the output of steganography operation is not apparently visible but in cryptography the output is scrambled so that it can draw attention. Steganlysis is process to detect of presence of steganography. In this article we have tried to elucidate the different approaches towards implementation of steganography using 'multimedia' file (text, static image, audio and video) and Network IP datagram as cover. Also some methods of steganalysis will be discussed.

  5. Legal approaches to injury prevention.

    Science.gov (United States)

    Swartz, E M

    1985-02-01

    Injury prevention can be achieved, but it will require a fundamental reexamination of our approach to injury causation. We must learn to examine the manufacturing and marketing practices of companies that produce the products associated with children's injuries, for these are the real culprits in our national childhood injury plague. Most importantly, we must learn to demand from industry that it take injury prevention seriously. If it refuses to do so it must face the consequences before the American system of justice. Legal advocacy can be a valuable tool in this effort. The legal system provides the means to pierce the corporate veil of secrecy and to learn how and why products are made of hazardous design. Under the light of public scrutiny, culprit companies can be made to pay the price for producing hazardous products. Only in this manner will industry be given the incentive to increase product safety. PMID:3975090

  6. [A historical approach to computing].

    Science.gov (United States)

    Babini, N

    1996-12-01

    Half a century after computers' conception, its effects, already reaching all human domains, seem to aim at becoming a universal transition similar to that one which marked in Occident the passage from artisanal production to industrial production among the 18 and 19 centuries, as from mechanisation to universal automation. It's considered that if this supposition may be correct, it would be urgent to intensify the historical approach of Informatics already present in may countries but not in ours. It's proposed the gradual incorporation of history of informatics in university careers beginning from research centers including teachers and researchers preparation, production and publication of works and the creation of museums and archives, to preserve physical testimonies and origin documents and the initial evolution of this scientific-technical invention which honours our century. PMID:11625366

  7. Variational approach to 68 Se

    International Nuclear Information System (INIS)

    For a unified description of the structure of medium mass proton-rich nuclei at low as well as high angular momenta we used the complex version of the Excited Vampir approach. We employed chains of variational calculations based on symmetry-projected essentially complex Hartree-Fock-Bogoliubov (HFB) vacua which include neutron-proton pairing and unnatural-parity correlations. Since the Vampir approaches allow the use of rather large model spaces and of general two-body interactions, large-scale nuclear structure studies going far beyond the abilities of the conventional shell-model configuration-mixing approach are possible. Furthermore, since these approaches provide detailed spectroscopic information for the lowest few states for each spin and parity, they also have considerable advantages with respect to the shell-model Monte Carlo method in which only expectation values of operators in the thermodynamic ensembles or the ground state can be calculated. Our previous investigations on microscopic aspects of shape coexistence in N?Z nuclei in the A?70 mass region indicated the presence of a strong competition between particular configurations based on large and small oblate and prolate quadrupole deformations. Furthermore, since in N = Z nuclei neutrons and protons fill the same single particle orbits, the isovector neutron-proton and the like-nucleon pairing correlations were found to be strongly competitive in even-even systems. In addition, the neutron and protems. In addition, the neutron and proton alignments with increasing angular momentum occur simultaneously in these nuclei. On the other hand the theoretical results suggest that certain properties of these nuclei are extremely sensitive to small variations of particular parts of the effective Hamiltonian. Thus, our results indicate that the oblate-prolate coexistence and mixing at low spins depend on the strengths of the neutron-proton T = 0 matrix elements involving nucleons occupying f5/2(f7/2) and g9/2 single particle orbits. Furthermore, our results concerning the pair structure of the wave functions of the even-spin states in chains of even-even and odd-odd N = Z nuclei in the A 60 - 80 mass region revealed a clear interplay between isovector neutron-proton and like-nucleon pairing correlations. Nevertheless, detailed aspects of these properties are sensitive to the renormalization of the effective interaction in the pairing channels. Taking advantage of our microscopic investigations on the coexistence phenomena in this mass region, which have already past many experimental tests, we address the problem of the structure of the lowest few even-spin positive-parity states in 68 Se. Also we present details of the results obtained using a few slightly different prescriptions for the effective interaction in order to illustrate the above mentioned problems. The theoretical spectrum of 68 Se for even spin positive parity states is compared with the experimental results. (authors)

  8. United kingdom approach and institutions

    International Nuclear Information System (INIS)

    The UK approach to legal requirements for instruction and training has been to specify broad objectives in the legislation and not to attempt to define in detail what qualifications or course of instruction should be held or followed to qualify workers for a particular task. The emphasis therefore is on the job being done safely and the employers' duty is to ensure that training and instruction are not the only factors. The UK Ionizing Radiations Regulations 1985 implement the Basic Safety Standards Directive which says, as respects instruction and training, that exposed workers shall be informed of the health risks involved in their work, the precautions to be taken and the importance of complying with technical and medical requirements and should also be given appropriate training in the field of radiation protection

  9. Operationalizing the integrated landscape approach in practice

    Directory of Open Access Journals (Sweden)

    Olivia E. Freeman

    2015-03-01

    the process of taking a landscape approach. Drawing on a review of the literature, we identify and discuss three different kinds of landscape approaches: using the landscape scale, a sectoral landscape approach, and an integrated landscape approach. Focusing on an integrated landscape approach, we examine five concepts to help characterize landscape approaches: multifunctionality, transdisciplinarity, participation, complexity, and sustainability. For each term, a continuum of application exists. To help improve and move the integrated landscape approach more toward operationalization, more focus needs to be placed on the process of taking the approach. Although the process can be implemented in a range of ways, in a more integrated approach it will require explicitly defined objectives as well as a clear understanding of what is meant by multifunctionality and sustainability. It will also require collaborative participation, transdisciplinarity/cross-sectoral approaches, managing for adaptive capacity, and applying an iterative process to address the inherent complexity within the system. Although these concepts are not new, we present continuums on which they can exist, allowing for clarification and distinctions to be made regarding what it means to take a landscape approach.

  10. Anisotropic flow in transport + hydrodynamics hybrid approaches

    International Nuclear Information System (INIS)

    This contribution to the focus issue covers anisotropic flow in hybrid approaches. The historical development of hybrid approaches and their impact on the interpretation of flow measurements is reviewed. The major ingredients of a hybrid approach and the transition criteria between transport and hydrodynamics are discussed. The results for anisotropic flow in (event-by-event) hybrid approaches are presented. Some hybrid approaches rely on hadronic transport for the late stages for the reaction (so called afterburner) and others employ transport approaches for the early non-equilibrium evolution. In addition, there are ‘full’ hybrid calculations where a fluid evolution is dynamically embedded in a transport simulation. After demonstrating the success of hybrid approaches at high Relativistic Heavy Ion Collider and Large Hadron Collider energies, existing hybrid caluclations for collective flow observables at lower beam energies are discussed and remaining challenges outlined. (paper)

  11. Spinal trauma. An imaging approach

    Energy Technology Data Exchange (ETDEWEB)

    Cassar-Pullicino, V.N. [The Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire (United Kingdom). Dept. of Radiology; Imhof, H. [University and General Hospital Vienna (Austria). Dept. of Radiodiagnostics

    2006-07-01

    The diagnosis of trauma to the spine - where the slightest oversight may have catastrophic results - requires a thorough grasp of the spectrum of resultant pathology as well as the imaging modalities used in making an accurate diagnosis. In Spinal Trauma, the internationally renowned team of experts provides a comprehensive, cutting-edge exposition of the current vital role of imaging in the diagnosis and treatment of injuries to the axial skeleton. Beginning with a valuable clinical perspective of spinal trauma, the book offers the reader a unique overview of the biomechanics underlying the pathology of cervical trauma. Acute trauma topics include: - Optimization of imaging modalities - Malalignment - signs and significance - Vertebral fractures - detection and implications - Classification of thoraco-lumbar fractures - rationale and relevance - Neurovascular injury. Distilling decades of clinical and teaching expertise, the contributors further discuss the current role of imaging in special focus topics, which include: - The pediatric spine - Sports injuries - The rigid spine - Trauma in the elderly - Vertebral collapse, benign and malignant - Spinal trauma therapy - Vertebral fractures and osteoporosis - Neuropathic spine. All throughout the book, the focus is on understanding the injury, and its implications and complications, through 'an imaging approach'. Lavishly illustrated with hundreds of superb MR images and CT scans, and clear full-color drawings, the authors conclude with a look into the future, defining clinical trends and research directions. Spinal Trauma - with its broad scope, practical imaging approach, and current focus - is designed to enhance confidence and accuracy, making it essential reading for clinicians and radiologists at all levels. (orig.)

  12. Spinal trauma. An imaging approach

    International Nuclear Information System (INIS)

    The diagnosis of trauma to the spine - where the slightest oversight may have catastrophic results - requires a thorough grasp of the spectrum of resultant pathology as well as the imaging modalities used in making an accurate diagnosis. In Spinal Trauma, the internationally renowned team of experts provides a comprehensive, cutting-edge exposition of the current vital role of imaging in the diagnosis and treatment of injuries to the axial skeleton. Beginning with a valuable clinical perspective of spinal trauma, the book offers the reader a unique overview of the biomechanics underlying the pathology of cervical trauma. Acute trauma topics include: - Optimization of imaging modalities - Malalignment - signs and significance - Vertebral fractures - detection and implications - Classification of thoraco-lumbar fractures - rationale and relevance - Neurovascular injury. Distilling decades of clinical and teaching expertise, the contributors further discuss the current role of imaging in special focus topics, which include: - The pediatric spine - Sports injuries - The rigid spine - Trauma in the elderly - Vertebral collapse, benign and malignant - Spinal trauma therapy - Vertebral fractures and osteoporosis - Neuropathic spine. All throughout the book, the focus is on understanding the injury, and its implications and complications, through 'an imaging approach'. Lavishly illustrated with hundreds of superb MR images and CT scans, and clear full-color drawings, the auths, and clear full-color drawings, the authors conclude with a look into the future, defining clinical trends and research directions. Spinal Trauma - with its broad scope, practical imaging approach, and current focus - is designed to enhance confidence and accuracy, making it essential reading for clinicians and radiologists at all levels. (orig.)

  13. Photochemical approaches to vision restoration.

    Science.gov (United States)

    Van Gelder, Russell N

    2015-06-01

    Photoswitches are traditional pharmacologic agonists, antagonists, or channel blockers that are covalently modified with an azobenzene derivative. Azobenzene undergoes wavelength-dependent isomerization between cis and trans conformation. For some photoswitches, only one of these configurations is biologically active, resulting in light-dependent activation or inhibition of function. Photoswitches that feature a quaternary ammonium coupled to the azobenzene moiety cause light-dependent neuronal depolarization due to blockage of voltage-gated potassium channels. Two photoswitch strategies have been pursued. In the one-component strategy, the photoswitch is applied to native receptors; in the two-component strategy, the photoswitch is combined with virally-mediated expression of a genetically modified receptor, to which the photoswitch may covalently bind. The former approach is simpler but the latter allows precise anatomic targeting of photoswitch activity. Acrylamide-azobenzene-quaternary ammonium (AAQ) is the prototypical first-generation one-component photoswitch. When applied to retinas with outer retinal degeneration, ganglion cell firing occurs in response to blue light, and is abrogated by green light. In vivo, AAQ restored pupillary light responses and behavioral light responses in blind animals. DENAQ is a prototypical second generation one-component photoswitch. It features spontaneous thermal relaxation so cell firing ceases in dark, and features a red-shifted activation spectrum. Interestingly, DENAQ only photoswitches in retinas with outer retinal degeneration. MAG is a photoswitched glutamate analog which covalently binds to a modified ionotropic glutamate receptor, LiGluR. When applied together, MAG and LiGluR also rescue physiologic and behavioral light responses in blind mice. Together, photoswitch compounds offer a potentially useful approach to restoration of vision in outer retinal degeneration. PMID:25680758

  14. Comprehensive approach to sarcopenia treatment.

    Science.gov (United States)

    Wakabayashi, Hidetaka; Sakuma, Kunihiro

    2014-05-01

    Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength with a risk of adverse outcomes such as physical disability, poor quality of life, and death. Primary sarcopenia is considered to be age-related when no other cause is evident, other than ageing itself. Secondary sarcopenia should be considered when one or more other causes are evident, such as activity-, disease-, or nutrition-related sarcopenia. In this narrative review that focused on human studies, we summarize the pharmaceutical therapies (testosterone, dehydroepiandrosterone, estrogen, growth hormone, ghrelin, vitamin D, angiotensin converting enzyme inhibitor, and eicosapentaenoic acid) and nonpharmaceutical therapies (resistance training, protein and amino acid supplementation, and non-smoking) for counteracting primary sarcopenia. Testosterone and growth hormone improve muscle mass and muscle strength, but have several side effects. Although there are some intriguing pharmaceutical therapies to combat sarcopenia, resistance training combined with supplements containing amino acids are the most effective for preventing and treating age-related muscle wasting and weakness. The etiology of sarcopenia in the elderly is multi-factorial. Patients with disuse syndrome and deconditioning often complicate the diagnosis, of not only activity-related sarcopenia, but also age-, disease-, and nutrition-related sarcopenia. In these cases a comprehensive approach to sarcopenia treatment should include pharmaceutical therapies for age-related sarcopenia and comorbid chronic diseases, resistance training, early ambulation, nutrition management, protein and amino acid supplementation, and non-smoking. The effect of pharmaceutical therapies for sarcopenia can be enhanced by this comprehensive approach. Future research on pharmaceutical therapies for counteracting sarcopenia should consider non-pharmaceutical therapies and also the causes of sarcopenia. PMID:24219006

  15. An intelligent approach to nanotechnology

    Science.gov (United States)

    Demming, Anna

    2013-11-01

    Control counts for little without a guiding principle. Whether manipulating atoms with a scanning probe or controlling carrier concentration in thin film deposition, intelligent intervention is required to steer the process from aimless precision towards a finely optimized design. In this issue G M Sacha and P Varona describe how artificial intelligence approaches can help towards modelling and simulating nanosystems, increasing our grasp of the nuances of these systems and how to optimize them for specific applications [1]. More than a labour-saving technique their review also suggests how genetic algorithms and artificial neural networks can supersede existing capabilities to tackle some of the challenges in moving a range of nanotechnologies forward. Research has made giant strides in determining not just what system parameters enhance performance but how. Nanoparticle synthesis is a typical example, where the field has shifted from simple synthesis and observation to unearthing insights as to dominating factors that can be identified and enlisted to control the morphological and chemical properties of synthesized products. One example is the neat study on reaction media viscosity for silver nanocrystal synthesis, where Park, Im and Park in Korea demonstrated a level of size control that had previously proved hard to achieve [2]. Silver nanoparticles have many potential applications including catalysis [3], sensing [4] and surface enhanced Raman scattering [5]. In their study, Park and colleagues obtain size-controlled 30 nm silver nanocrystals in a viscosity controlled medium of 1,5-pentanediol and demonstrate their use as sacrificial cores for the fabrication of a low-refractive filler. Another nanomaterial that has barely seen an ebb in research activity over the past two decades is ZnO, with a legion of reports detailing how to produce ZnO in different nanoscale forms from rods [6], belts [7] and flowers [8] to highly ordered arrays of vertically aligned nanowires. In particular, the arrays of high aspect ratio nanowires have piqued recent interest for potential piezoelectric 'nanogenerator' applications. Yet just because you can does not mean you should, and as always any alleviation of the structural requirements for exploiting these systems is helpful. Interest in the piezoelectric properties motivated a theoretical and finite element analysis of the behaviour of aligned ZnO nanowires under compression by Romano and researchers in the US and Italy [9]. Their study concludes that the nanowire length does not significantly affect the output piezopotential, which as they suggest 'is an important result for wet-chemistry fabrication of low-cost, CMOS- or MEMS-compatible nanogenerators'. Evidently exploiting nanostructures requires an intelligent approach so that we can harness the eccentricities of their behaviour most effectively for empowering new technologies. However, as G M Sacha and P Varona point out in this issue, that intelligence need not be human [1]. They describe a number of situations—from modelling scanning probe tools and interpreting their data to extracting solutions from DNA computers—where genetic algorithms and artificial neural networks can take the place of an expert, and for some applications achieve what broaches the impossible with the methods otherwise available. Over the past few decades computers have infiltrated everyday life at an astonishing rate and it is widely recognized that now without them, the Western world would fall apart. Yet what machine learning and fuzzy logic may offer could trivialize even our existing machine reliance. Real implementation of artificial intelligence is so far scarce in technology. However it has been on the radar in science fiction for so long it almost sounds retro, and its popularity in dystopian futuristic novels has tinged the term with a melodrama that may seem inappropriate for science. In fact as the review in this issue illustrates, artificial intelligence and machine learning approaches already offer a potent suite of tools to nanotechnolo

  16. Understanding Progress: A Heterodox Approach

    Directory of Open Access Journals (Sweden)

    Blanca Lemus

    2013-01-01

    Full Text Available This paper examines the possibility of understanding and measuring well-being as a result of “progress” on the basis of today’s dominant epistemological framework. Market criteria distort social values by allowing purchasing power to define priorities, likening luxury goods to basic needs; in the process they reinforce patterns of discrimination against disadvantaged social groups and women, introducing fatal distortions into the analysis. Similarly, because there are no appropriate mechanisms to price natural resources adequately, the market overlooks the consequences of the abuse of natural resources, degrading the quality of life, individually and collectively, or—in the framework of Latin American indigenous groups—foreclosing the possibility of “living well”. We critique the common vision of the official development discourse that places its faith on technological innovations to resolve these problems. The analysis points to the need for new models of social and environmental governance to promote progress, approaches like those suggested in the paper that are inconsistent with public policies currently in place. At present, the social groups forging institutions to assure their own well-being and ecological balance are involved in local processes, often in opposition to the proposals of the political leaders in their countries.

  17. Astronomy 2020: A Pragmatic Approach

    Science.gov (United States)

    Graham, M. J.

    2009-09-01

    In the cinema history of astronomy, we are currently at the stage of the Lumiere brothers with contemporary surveys providing short monochromatic time sequences of the sky. By the end of the next decade, however, panchromatic blockbusters will be commonplace and science will be predominantly driven by the objects that change in successive ``frames''. Web-scale computing resources will be required just to process the torrents of data events but the key to understanding them will be contextualisation --- linking together disparate (sets of) events and relating them to archival and supplementary data in a machine-comprehensible way. Much of the data mining and analysis of such data portfolios will be performed by proxy scientists --- intelligent agent avatars that represent an individual's particular research interests in high-dimension parameter spaces. Although this view might sound like science fiction, in this paper, I will review the technologies that will make it achievable. In particular, I will cover new approaches to web services that will be required to support these massive event streams, social networking techniques that will facilitate science and semantic technologies that will underpin everything.

  18. Microinvasive melanoma: cutaneous pharmacotherapeutic approaches.

    Science.gov (United States)

    Quigley, Elizabeth A; Halpern, Allan C

    2013-04-01

    Surgical excision is the treatment of choice for primary melanomas and radiation therapy is the accepted alternative for the subset of lesions not amenable to surgery. With the recent rise in melanoma incidence, especially in the elderly, there are a growing number of cases that are neither amenable to surgery nor radiation therapy. In this article, we review pharmacotherapeutic approaches to microinvasive melanoma (invasive radial growth phase melanoma) that might be considered in such circumstances. There are no approved drugs for the treatment of primary melanoma and randomized controlled trials with 5 or more years of follow-up have not been performed. The limited studies and numerous case series in the literature on pharmacologic treatment of primary melanoma have focused on topical therapies. Accordingly, we provide a review of the potential pharmacotherapeutic agents in the treatment of microinvasive melanoma by extrapolating from the available limited literature on the use of fluorouracil, azelaic acid, retinoic acid derivatives, interferon (IFN)-?, imiquimod, and other agents for melanoma in situ, invasive melanoma, and epidermotropic melanoma metastases. Our review indicates that topical fluorouracil and tretinoin are not effective as single agents. The efficacy of azelaic acid, tazarotene, cidofovir, and intralesional IFN-?, interleukin-2, and IFN-? is undefined. Imiquimod is the most studied and promising agent; however, optimal dosage, therapeutic regimen, and survival rates are unknown. In the face of a growing demand for non-surgical treatments, formal clinical trials are needed to ascertain the role of pharmacotherapeutic agents in the treatment of microinvasive melanoma. PMID:23479385

  19. Semilocal approach to nonlocal equations

    International Nuclear Information System (INIS)

    One can classify nonlocal equations according to the value of a parameter, defined as the ratio between the range of nonlocality and the characteristic length of the diagonal part of the integral kernel. When this ratio is small, one can derive a local (differential) equation, which approximately reproduces the solutions of the nonlocal equation. Then using the methods already existing for the analysis of differential equations one can, with a relatively small effort, describe the properties of the solutions of nonlocal equations. It is not possible to attach to every nonlocal Schroedinger equation an equivalent local one (i.e. a differential equation of second order). The reason is that the spectrum of nonlocal equations is much richer and cannot be reproduced with a second order differential equation. When this is the case, the behaviour of the solutions of nonlocal equations is similar to that corresponding to nonlinear equations. The method presented here provides one not only with a quite simple approach for studying the properties of nonlocal equations, but also with a fairly accurate method of approximate solution, when the above-mentioned parameter is reasonably small. (orig.)

  20. The Structural Collapse Approach Reconsidered

    Scientific Electronic Library Online (English)

    Ignacio, Ojea.

    2012-05-01

    Full Text Available En este trabajo argumentaré que la reformulación que Roy Cook (forthcoming) hace de la paradoja de yablo en el sistema infinitario D es una genuina paradoja no circular, pero por motivos distintos a los defendidos por ese autor. La primera parte del trabajo consiste en mostrar que la ausencia de pun [...] tos fijos en la construcción es insuficiente para demostrar su no circularidad, a lo sumo prueba su no autorreferencialidad. La segunda parte consiste en volver a considerar el enfoque del colapso estructural que Cook rechaza, y argumentar que una correcta comprensión del mismo revela que la paradoja es genuinamente no circular. Abstract in english I will argue that Roy Cook’s (forthcoming) reformulation of Yablo’s Paradox in the infinitary system D is a genuinely non-circular paradox, but for different reasons than the ones he sustained. In fact, the first part of the job will be to show that his argument regarding the absence of fixed points [...] in the construction is insufficient to prove the noncircularity of it; at much it proves its non-self referentiality. The second is to reconsider the structural collapse approach Cook rejects, and argue that a correct understanding of it leads us to the claim that the infinitary paradox is actually non-circular.

  1. ECG Signal Analysis: Different Approaches

    Directory of Open Access Journals (Sweden)

    S. Thulasi Prasad

    2014-01-01

    Full Text Available In recent years scientists and engineers are facing several challenges in solving biomedical problems and making Digital Signal Processing as an essential and effective pedagogical approach to solve a problem of detecting selected arrhythmia conditions from a patient’s electrocardiograph (ECG signals. The detection of QRS complex has many clinical applications as it marks the beginning of the left ventricular contraction. A lot of possible heart malfunctions such as cardiac arrhythmias, transient ischemic episodes and silent myocardial ischemia or failures will be slow while monitoring of ECG signal in real-time during normal activity. Introducing an efficient method for arrhythmia detection can be very useful for better conceptual understanding of signal processing. In this paper, we discussed two methods to clean ECG signal corrupted by noise and to extract required parameters for detecting arrhythmia condition. One method is Hilbert Transform method and another method is Filter Bank method. These methods involve using filter techniques, algorithms of finding peaks & valleys, local maxima & minima etc, for determining R peaks, R-R intervals and QRS complexes.

  2. Reactor Protection Systems. Diverse Approaches

    International Nuclear Information System (INIS)

    Defence in depth design criteria applied to nuclear instrumentation, in particular, to reactor protection systems (RPS), include redundancy, diversity and fail-safe behaviour. Typically, two out of three ('2oo3'), majority-voting systems meet redundancy criteria. A careful analysis of signal levels and polarity and the use of several techniques, such as lives zeros, bias toward safe state, etc. guarantee the same degree of fail-safe behaviour. Diversity criteria, in general, are met by the whole system using more than one method to protect the integrity of reactor (i.e. rod drop plus boron injection), but not for the single instrumentation chain. Moreover, the increasing information needs of supervision systems encourage the use of digital instrumentation in RPS; if the digital instrumentation has software based implementation, the diversity requirement will be mandatory for the instrumentation of each system. In the paper, three possible configurations of the first protection system (rod drop) are analysed. The first one is the traditional hardware approach, the second one is a software based system, and the last one is a proposed mix system. For all configurations, a redundant system two out of four ('2oo4') is assumed. Availability and reliability points of view are taken into account. The proposed mix system is explained in full detail. A discussion about programmable logic and its considerations are introduced. A CPLD based system in a research reactor (RA1) and ed system in a research reactor (RA1) and its functionality are explained. (author)

  3. Approaching invasive species in Madagascar

    Directory of Open Access Journals (Sweden)

    Christian A. Kull

    2014-12-01

    Full Text Available While a number of plants, animals, and insects in Madagascar have been called ’invasive’, the topic of invasive species has until recently received less attention here than in other island contexts. Some species, often alien to Madagascar and introduced by humans, have expanded their range rapidly and have had both negative and positive effects on landscapes, on native biodiversity, and on livelihoods. Examples include the prickly pear (raketa, the silver wattle (mimosa, and, recently, the Asian common toad (radaka boka. Building on a conceptual approach to ’invasive species’, this paper emphasizes the importance of inclusive and deliberative site- and population - specific management of invasive species. It analyses three separate concepts commonly used in definitions of invasion: the origin, behaviour, and effects of particular species. It places these concepts in their broader social and ecological context, with particular attention to local perspectives on invasive species. We illustrate these concepts with Malagasy examples and data. The examples demonstrate that while invasions can have dramatic consequences, there can be multiple, often competing, interests as well as site - specific biophysical, environmental, and cultural considerations that need to be taken into account when designing policy and management interventions. We conclude with a number of lessons learned.

  4. Ancient Climatic Architectural Design Approach

    Directory of Open Access Journals (Sweden)

    Nasibeh Faghih

    2013-01-01

    Full Text Available Ancient climatic architecture had found out a series of appropriate responses for the best compatibility with the critical climate condition for instance, designing ‘earth sheltered houses’ and ‘courtyard houses’. They could provide human climatic comfort without excessive usage of fossil fuel resources. Owing to the normal thermal conditions in the ground depth, earth sheltered houses can be slightly affected by thermal fluctuations due to being within the earth. In depth further than 6.1 meters, temperature alternation is minute during the year, equaling to average annual temperature of outside. More to the point, courtyard buildings as another traditional design approach, have prepared controlled climatic space based on creating the maximum shade in the summer and maximum solar heat absorption in the winter. The courtyard houses served the multiple functions of lighting to the rooms, acting as a heat absorber in the summer and a radiator in the winter, as well as providing an open space inside for community activities. It must be noted that they divided into summer and winter zones located in south and north of the central courtyard where residents were replaced into them according to changing the seasons. Therefore, Ancient climatic buildings provided better human thermal comfort in comparison with the use contemporary buildings of recent years, except with the air conditioning

  5. System approach to MEMS commercialization

    Science.gov (United States)

    Vaganov, Vladimir I.; Belov, Nickolai; in't Hout, Sebastiaan R.

    2003-04-01

    It is common to underestimate the challenges of integrating the at least four technologies in any MEMS product: the three technologies of any semiconductor device (electronics, packaging and testing) plus the MEMS microstructure. For some specific areas of application, for example for photonics, optics technology/components must also be integrated. While traditional semiconductor devices utilize standardized and inexpensive packaging and testing procedures and equipment, MEMS require custom solutions that introduce multiple physical domains, such as light in the case of photonics, directly to a potentially moving structure on the die. This heightened complexity coupled with nonstandard packaging, testing and other (optics) technologies has a dramatic impact on functionality, reliability and cost. Being developed and successfully proven for a period of about twenty-five years the System Approach to MEMS Commercialization is based on three major principles: A priori understanding of the interdependence of technologies integrated into MEMS products: micro-machining, IC technology, packaging, testing and other (optics) technologies. Parallel development or implementation of these technologies within the MEMS product. Redistribution of manufacturing complexity from individual to batch realm. Integrating packaging and testing and other (optics) components into the microstructure and including some of the testing and functional algorithms in the ASIC reduce cost by simplifying more expensive individual manufacturing steps. The overall results of redistribution complexity from individual manufacturing technologies into batch manufacturing technologies are dramatic cost reduction, performance and quality improvement and shorter time to market.

  6. Repository Closure and Sealing Approach

    International Nuclear Information System (INIS)

    The scope of this analysis will be to develop the conceptual design of the closure seals and their locations in the Subsurface Facilities. The design will be based on the recently established program requirements for transitioning to the Site Recommendation (SR) design as outlined by ''Approach to Implementing the Site Recommendation Baseline'' (Stroupe 2000) and the ''Monitored Geologic Repository Project Description Document'' (CRWMS M andO 1999b). The objective of this analysis will be to assist in providing a description for the Subsurface Facilities System Description Document, Section 2 and finally to document any conclusions reached in order to contribute and provide support to the SR. This analysis is at a conceptual level and is considered adequate to support the SR design. The final closure barriers and seals for the ventilation shafts, and the north and south ramps will require these openings to be permanently sealed to limit excessive air and water inflows and prevent human intrusion. The major tasks identified with closure in this analysis are: (1) Developing the overall subsurface seal layout and identifying design and operational interfaces for the Subsurface Facilities. (2) Summarizing the general site conditions and general rock characteristic with respect to seal location and describing the seal selected. (3) Identify seal construction materials, methodology of construction and strategic locations including design of the seal and plugs. (4) Discussing methods to prevent human intrusion

  7. Waste Characterization: Approaches and Methods

    DEFF Research Database (Denmark)

    Lagerkvist, A.; Ecke, H.

    2011-01-01

    Characterization of solid waste is usually a difficult task because of the heterogeneity of the waste and its spatial as well as temporal variations. This makes waste characterization costly if good and reliable data with reasonable uncertainty is to be obtained. Therefore, a waste characterization is often narrowly defined to meet specific needs for information. This may however limit the general usefulness of the information gained, for example, if the specific purpose limited the characterization to a subset of variables. In general, data available in the solid waste area are limited and often with limited representation. This chapter describes common approaches and methods in waste characterization including common terms, sampling, characterization methods and data evaluation. The focus is on the characterization of waste as it is generated or collected, while specific issues on characterization related to individual treatment processes and waste products are dealt with in the following chapters: Characteristic data on residential waste (Chapter 2.2), commercial and institutional waste (Chapter 2.3), industrial waste (Chapter 2.4) and construction and demolition waste (Chapter 2.5). If information about waste is required, it is always advisable to check the literature and the internet to see if relevant data is available already. However, in all cases the relevance of the data with respect to cultural, climatic and economical basis as well as the quality and age of the data available must be carefully assessed.

  8. Semantic Approach for Query Explication

    Directory of Open Access Journals (Sweden)

    Shruti Gupta

    2013-06-01

    Full Text Available The main focus is to add a new dimension to Internet-Searching and that is to apply semantic aspects towards it. An essential requirement of this work is one has to recognize the difference between what a user might say or do and what she or he actually meant or intended. In more simple words, “the search must be what user wish, not what he/she types”. Quering the search engine for any particular topic would retrieve the results from the internet and presented to the web users. Since there are large number of web pages on the internet and thus result obtained are also vast. User gets more than enough web links as a result produced by search engine and wastes their precious time in navigating through unwanted links, searching the needed one. The main reason for this is that the Search Engine do the indexing of the pages on the basis of text entered by user. In order to overcome this shortcoming we need to implement a method that will allow the user to find the relevant words, starting from the few words that they may actually know [5].In other words, we need to focus on the semantic of words entered by user and for this purpose a new approach that is based on some algorithms which considers semantic aspects should be included. One of such technique for the semantic analysis is the Latent Semantic analysis and Probabilistic Latent Semantic Analysis.

  9. Approach to crevice chemistry inferences

    International Nuclear Information System (INIS)

    An approach to crevice chemistry inferences is presented. NWT reviewed the ionic species return after plant cooldown data for twelve PWRs. The data are limited since, generally, only data for sodium, magnesium and calcium cations, and chloride and sulfate anions are included. The solution chemistries were reviewed with respect to cation to anion equivalence ratios based on the following assumptions: all sodium, potassium, chloride and fluoride remain soluble; sulfate precipitates to the extent that calcium is present with residual sulfate remaining soluble; and all remaining calcium and magnesium precipitates as silicates. Plant chemistries were inferred as basic if their cation to anion equivalence ratio was greater than about 1.2 and acidic if the ratio was less than about 0.8. The total return chemistries after shutdown for various outages for the twelve plants were identified. The inferred pH conditions are also identified for each of those outages. These inferred pH conditions were then compared with the occurrence of intergranular attack (IGA) and intergranular stress corrosion cracking (IGSCC) in the plants' steam generators. The occurrence of IGA and IGSCC appeared to correlate with an inferred pH that was basic. Plants with acidic conditions or with basic conditions and a phosphate buffer did not experience this corrosion

  10. Australia: Approaching an energy crossroads

    International Nuclear Information System (INIS)

    This paper considers energy policy in Australia in the context of its considerable energy resources, climate change and a recent change in government. It examines the possible paths that future energy use and policy in Australia could take, including published projections based largely on a 'business as usual' approach and projections based on a dramatic shift towards more efficient use of energy and renewable energy technologies. It also considers the various factors affecting future policy direction, including energy security, the advocacy in Australia for establishing nuclear electricity generation and other parts of the nuclear fuel-cycle, responses to climate change, and carbon sequestration. It concludes that while the Australian Government is currently reluctant to move away from a dependence on coal, and unlikely to adopt nuclear energy generation, a low-emissions future without waiting for the deployment of carbon capture and storage and without resorting to nuclear power is within reach. However, in the face of strong pressure from interest groups associated with energy intensive industry, making the necessary innovations will require further growth of community concern about climate change, and the development of greater understanding of the feasibility of employing low carbon-emissions options.

  11. Conceptual Approach to Forecasting Demand ?????????????? ?????? ? ??????????????? ??????

    Directory of Open Access Journals (Sweden)

    Andreishina Nataliia B.

    2013-06-01

    Full Text Available The article considers a conceptual approach to forecasting demand on products of a production or trading company using economic and mathematical methods. It justifies importance of modelling and forecasting consumer demand on goods. It provides a classification of methods of forecasting demand in two dimensions: from subjective to objective ones and from na?ve to cause-effect ones. It systemises groups of factors that influence demand and analyses character of their influence. It develops a concept of forecasting demand on products of a company using economic and mathematical methods, which consists of four stages: identification of factors that influence demand, selection of mathematical dependence, check of adequacy and accuracy of the model and forecast of demand. It builds forecast demand models for a specific trading company: Brown’s adaptive polynomial model of the first order; and two-factor model, demand in which depends on the price of a good and its changes. It checks adequacy of each model and performs forecast of demand on products of a company.? ?????? ?????????? ?????????????? ?????? ? ??????????????? ?????? ?? ????????? ????????????????? ??? ????????? ??????????? ?????????-??????????????? ????????. ?????????? ???????????? ????????????? ? ??????????????? ???????????????? ?????? ?? ??????. ????????? ????????????? ??????? ??????????????? ?????? ?? ???? ??????????: ?? ???????????? ? ??????????? ? ?? ??????? ? ????????-????????????. ????????????????? ?????? ????????, ???????? ?? ?????, ??????????????? ???????? ?? ???????. ??????? ????????? ??????????????? ?????? ?? ????????? ??????????? ?????????-??????????????? ????????, ??????? ??????? ?? ??????? ??????: ??????????? ????????, ???????? ?? ?????, ????? ?????????????? ???????????, ???????? ???????????? ? ???????? ?????? ? ??????? ??????. ??? ??????????? ????????? ??????????? ????????? ?????????? ?????? ??????: ?????????? ?????????????? ?????? ?????? ??????? ???????; ????????????? ??????, ? ??????? ????? ??????? ?? ???? ?????? ? ?? ?????????. ????????? ???????????? ?????? ?????? ? ???????? ??????? ?????? ?? ????????? ???????????.

  12. Deficient approaches to human neuroimaging

    DEFF Research Database (Denmark)

    Stelzer, Johannes; Lohmann, Gabriele

    2014-01-01

    Functional magnetic resonance imaging (fMRI) is the workhorse of imaging-based human cognitive neuroscience. The use of fMRI is ever-increasing; within the last 4 years more fMRI studies have been published than in the previous 17 years. This large body of research has mainly focused on the functional localization of condition- or stimulus-dependent changes in the blood-oxygenation-level dependent signal. In recent years, however, many aspects of the commonly practiced analysis frameworks and methodologies have been critically reassessed. Here we summarize these critiques, providing an overview of the major conceptual and practical deficiencies in widely used brain-mapping approaches, and exemplify some of these issues by the use of imaging data and simulations. In particular, we discuss the inherent pitfalls and shortcomings of methodologies for statistical parametric mapping. Our critique emphasizes recent reports of excessively high numbers of both false positive and false negative findings in fMRI brain mapping. We outline our view regarding the broader scientific implications of these methodological considerations and briefly discuss possible solutions.

  13. Approaching ? without fine-tuning

    International Nuclear Information System (INIS)

    We address the fine-tuning problem of dark energy cosmologies which arises when the dark energy density needs to initially lie in a narrow range in order for its present value to be consistent with observations. As recently noticed, this problem becomes particularly severe in canonical quintessence scenarios, when trying to reproduce the behavior of a cosmological constant, i.e., when the dark energy equation of state wQ approaches -1: these models may be reconciled with a large basin of attraction only by requiring a rapid evolution of wQ at low redshifts, which is in conflict with the most recent estimates from type Ia Supernovae discovered by Hubble space telescope. Next, we focus on scalar-tensor theories of gravity, discussing the implications of a coupling between the quintessence scalar field and the Ricci scalar ('extended quintessence'). We show that, even if the equation of state today is very close to -1, by virtue of the scalar-tensor coupling the quintessence trajectories still possess the attractive feature which allows to reach the present level of cosmic acceleration starting by a set of initial conditions which covers tens of orders of magnitude; this effect, entirely of gravitational origin, represents a new important consequence of the possible coupling between dark energy and gravity. We illustrate this effect in typical extended quintessence scenarios

  14. Dosimetric approaches: pregnancy and lactation

    International Nuclear Information System (INIS)

    The female nuclear medicine patient is of special concern to the evaluation of radiation dose since radiation protection point of view: a)- The females overall body size and organ sizes are generally smaller than those of her male counterpart (thus her radiation doses will be higher, given the same amounts of administered activity and similar biokinetics), the effective doses could be 25 per cent higher than a man; b)- Female gonads are inside the body instead of outside and are near several organs often important as source organs in internal dosimetry; female gonads doses could be up to 10 or 30 higher than male gonads (usually 3 order); c)- Risk of breast cancer is significantly higher among females than males; d)- During the pregnancy due to placental transfer of radiopharmaceuticals or radiation exposure from the urinary bladder the embryo/fetus could receive doses that must be avoid; e)- In the case of nursing infant is of special concern in such an analysis to determine the interruption period to avoid doses in the nursing infant. The dosimetric approaches to take account to assess internal doses in the pregnant woman and during the breast feeding are discussed. (author)

  15. Approaches to high energy physics

    International Nuclear Information System (INIS)

    An overview of the present state of the art in high energy physics is presented highlighting the developments in hadron physics, field theory and nuclear democracy. To begin with, description of 'hadrons' is given on the basis of quantum electrodynamics. The role of the quantum numbers assigned to quarks are explained. Lepton-hadron scattering and hadron-hadron scattering are discussed. The quark-parton model of the nucleon is explained. The recently discovered Psi resonances and the consequent introduction of new quantum number 'charm' are mentioned. Next, Yang-Mills Gauge theories, the unification of weak and electromagnetic interactions and the concept of weak neutral currents are discussed. Gauge theories of strong interactions, quantum chromodynamics and the concept of 'Bags' are explained. Magnetic monopoles (solitons) are described with basis on non-linear field theories. High energy bounds in the axiomatic field theory are formulated. The general properties of S-matrix elements obtained in a quantum local field theory are mentioned. Lastly, the shifting of the reliance on field concepts to other approaches, specially through S-matrix and the application of Regge poles and cuts is explained. The duality hypothesis is postulated to explain processes such as pp?pp with the 'pomeron exchange' concept. Dual models of strong interactions are discussed. Future trends are indicated. (A.K.)

  16. Diagnostic approach to peripheral neuropathy

    Directory of Open Access Journals (Sweden)

    Misra Usha

    2008-01-01

    Full Text Available Peripheral neuropathy refers to disorders of the peripheral nervous system. They have numerous causes and diverse presentations; hence, a systematic and logical approach is needed for cost-effective diagnosis, especially of treatable neuropathies. A detailed history of symptoms, family and occupational history should be obtained. General and systemic examinations provide valuable clues. Neurological examinations investigating sensory, motor and autonomic signs help to define the topography and nature of neuropathy. Large fiber neuropathy manifests with the loss of joint position and vibration sense and sensory ataxia, whereas small fiber neuropathy manifests with the impairment of pain, temperature and autonomic functions. Electrodiagnostic (EDx tests include sensory, motor nerve conduction, F response, H reflex and needle electromyography (EMG. EDx helps in documenting the extent of sensory motor deficits, categorizing demyelinating (prolonged terminal latency, slowing of nerve conduction velocity, dispersion and conduction block and axonal (marginal slowing of nerve conduction and small compound muscle or sensory action potential and dennervation on EMG. Uniform demyelinating features are suggestive of hereditary demyelination, whereas difference between nerves and segments of the same nerve favor acquired demyelination. Finally, neuropathy is classified into mononeuropathy commonly due to entrapment or trauma; mononeuropathy multiplex commonly due to leprosy and vasculitis; and polyneuropathy due to systemic, metabolic or toxic etiology. Laboratory investigations are carried out as indicated and specialized tests such as biochemical, immunological, genetic studies, cerebrospinal fluid (CSF examination and nerve biopsy are carried out in selected patients. Approximately 20% patients with neuropathy remain undiagnosed but the prognosis is not bad in them.

  17. Current clinical approach to achalasia

    Directory of Open Access Journals (Sweden)

    Alexander J Eckardt, Volker F Eckardt

    2009-08-01

    Full Text Available Idiopathic achalasia is a rare primary motility disorder of the esophagus. The classical features are incomplete relaxation of a frequently hypertensive lower esophageal sphincter (LES and a lack of peristalsis in the tubular esophagus. These motor abnormalities lead to dysphagia, stasis, regurgitation, weight loss, or secondary respiratory complications. Although major strides have been made in understanding the pathogenesis of this rare disorder, including a probable autoimmune mediated destruction of inhibitory neurons in response to an unknown insult in genetically susceptible individuals, a definite trigger has not been identified. The diagnosis of achalasia is suggested by clinical features and confirmed by further diagnostic tests, such as esophagogastroduodenoscopy (EGD, manometry or barium swallow. These studies are not only used to exclude pseudoachalasia, but also might help to categorize the disease by severity or clinical subtype. Recent advances in diagnostic methods, including high resolution manometry (HRM, might allow prediction of treatment responses. The primary treatments for achieving long-term symptom relief are surgery and endoscopic methods. Although limited high-quality data exist, it appears that laparoscopic Heller myotomy with partial fundoplication is superior to endoscopic methods in achieving long-term relief of symptoms in the majority of patients. However, the current clinical approach to achalasia will depend not only on patients’ characteristics and clinical subtypes of the disease, but also on local expertise and patient preferences.

  18. An Eliminativist Approach to Vulnerability.

    Science.gov (United States)

    Wrigley, Anthony

    2014-11-25

    The concept of vulnerability has been subject to numerous different interpretations but accounts are still beset with significant problems as to their adequacy, such as their contentious application or the lack of genuine explanatory role for the concept. The constant failure to provide a compelling conceptual analysis and satisfactory definition leaves the concept open to an eliminativist move whereby we can question whether we need the concept at all. I highlight problems with various kinds of approach and explain why a satisfactory account of vulnerability is unlikely ever to be offered if we wish the concept to play a genuinely explanatory role in bioethical contexts. I outline why an eliminativist position should be taken with regard to this concept in light of these concerns but mitigate some of the severity of this position by arguing that we can still make sense of retaining our widespread use of the term by viewing it as nothing more than a useful pragmatic linguistic device that acts as a marker to draw attention to certain kinds of issue. These issues will be entirely governed by other, better understood ethical concepts and theories. PMID:25425540

  19. Investment Portfolio Evaluation by the Fuzzy Approach

    Directory of Open Access Journals (Sweden)

    Lambovska Maya

    2011-09-01

    Full Text Available This paper presents a new fuzzy approach for the evaluation of investment portfolio, where the approach is viewed by the authors as a sub-phase of the management process of these portfolios. The approach defines the mutual and delayed effects among the significant variables of the investment portfolio. The evaluation of the effects is described as fuzzy trapezoidal numbers and they are aggregated by mathematical operations with incidence matrices and fuzzy functions “experton”.

  20. The clebsch potential approach to fluid lagrangians

    OpenAIRE

    Roberts, Mark D.

    2009-01-01

    The clebsch potential approach to fluid lagrangians is developed in order to establish contact with other approaches to fluids. Three variants of the perfect fluid approach are looked at. The first is an explicit linear lagrangian constructed directly from the clebsch potentials, this has fixed equation of state and explicit expression for the pressure but is less general than a perfect fluid. The second is lagrangians more general than that of a perfect fluid which are cons...

  1. The PNEI holistic approach in coloproctology.

    Science.gov (United States)

    Pescatori, M; Podzemny, V; Pescatori, L C; Dore, M P; Bassotti, G

    2015-05-01

    The psycho-neuroendocrine-immune approach relies on the concept of considering diseases from a holistic point of view: the various components (psyche, nervous system, endocrine system, and immune system) control the diseased organ/apparatus and in turn are influenced by a feedback mechanism. In this article, we will consider the psycho-neuroendocrine-immune approach to coloproctological disorders, by providing clinical cases and discussing them in light of this approach. PMID:25820513

  2. THE SOCIOLOGIC APPROACH OF FEMININE CRIMINALITY

    OpenAIRE

    MIRELA CRISTIANA NILA STRATONE; BOGDAN GEORGESCU

    2012-01-01

    The present study is part of a much more cognitive approach, which tries to study resocialization and the social reinsertion of women who are under freedom privation penalty. The present material contains a short historical evolution of the sociologic theories of crime, then plunging towards feminist theories, in order to approach the gender problematic concerning the delinquent woman.. The first objective is to demonstrate the necessity of a wider approach in analyzing the genesis of the cri...

  3. A Geometric Approach to Noncommutative Principal Bundles

    OpenAIRE

    Wagner, Stefan

    2011-01-01

    From a geometrical point of view it is, so far, not sufficiently well understood what should be a "noncommutative principal bundle". Still, there is a well-developed abstract algebraic approach using the theory of Hopf algebras. An important handicap of this approach is the ignorance of topological and geometrical aspects. The aim of this thesis is to develop a geometrically oriented approach to the noncommutative geometry of principal bundles based on dynamical systems and ...

  4. English Reading Base on Social Constructivist Approach

    OpenAIRE

    Qian Huang

    2009-01-01

    This paper explains the constructivist approach to reading teaching and shows how a dialogic approach to reading empowers readers to position themselves as participants in making meaning together with the text and its authors, rather than remaining as mute outsiders to the reading process. This shift in constructing reader -roles means that our students need to take a strategic approach to their reading, and will need careful scaffolding to help them develop effective, independent reading str...

  5. An instrumental approach to deception in bargaining

    OpenAIRE

    Koning, Lukas Frederik

    2011-01-01

    Deception is often described as a form of unethical behavior, yet it is frequently used in bargaining. This raises the question why people use deception in bargaining. In this dissertation an instrumental approach to deception is presented to help answer this question. In an instrumental approach, the use of deception depends on both the goals bargainers pursue and the means they have to attain their goals. An instrumental approach presupposes that bargainers select the means they consider mo...

  6. Implementing Loss Distribution Approach for Operational Risk

    OpenAIRE

    Shevchenko, Pavel V.

    2009-01-01

    To quantify the operational risk capital charge under the current regulatory framework for banking supervision, referred to as Basel II, many banks adopt the Loss Distribution Approach. There are many modeling issues that should be resolved to use the approach in practice. In this paper we review the quantitative methods suggested in literature for implementation of the approach. In particular, the use of the Bayesian inference method that allows to take expert judgement and...

  7. Surgical approaches for cesarean section in cattle

    OpenAIRE

    Schultz, Loren G.; Tyler, Jeff W.; Moll, H. David; Constantinescu, Gheorghe M.

    2008-01-01

    Bovine practitioners are often presented with dystocias that require a cesarean section. Many practitioners perform this surgery using the same approach each time due to their comfort with one specific approach or lack of familiarity of other available options. The goal of this article is to explain the advantages, disadvantages, and indications for each of the different approaches to aid the practitioner in achieving better surgical success rate.

  8. A regularization approach to hydrofacies delineation

    Energy Technology Data Exchange (ETDEWEB)

    Wohlberg, Brendt [Los Alamos National Laboratory; Tartakovsky, Daniel [UNIV OF CALIFORNIA

    2009-01-01

    We consider an inverse problem of identifying complex internal structures of composite (geological) materials from sparse measurements of system parameters and system states. Two conceptual frameworks for identifying internal boundaries between constitutive materials in a composite are considered. A sequential approach relies on support vector machines, nearest neighbor classifiers, or geostatistics to reconstruct boundaries from measurements of system parameters and then uses system states data to refine the reconstruction. A joint approach inverts the two data sets simultaneously by employing a regularization approach.

  9. Belene nuclear power plant contracting approach

    International Nuclear Information System (INIS)

    Historically, three main types of project execution and contractual approaches have been applied to energy and industrial projects, including nuclear projects. These approaches are grouped into three broad categories: 1) Turnkey Approach; 2) Split Package (Island) Approach; and 3)Multiple Package Approach. Based on a preliminary screening done by an ongoing feasibility study work for NPP Belene (NEK contract to Parsons E and C), the recommended approach is going to follow that general trend i.e., with some variation between the Split Package and the Turnkey approach. Before deciding on an execution approach or at least before issuing bid specifications for the nuclear power plant, it is prudent, even for a country with existing nuclear power program (like Bulgaria), to re-check/verify capabilities of the interested bidders to handle contracts of this size and nature. During the last decades, nuclear energy went through a substantial restructuring and most of the capabilities (human and financial) that existed before are not any more available. This re-checking should mainly cover the experience of the bidders as regards the design, construction and operation of the stations where they were involved, but also include items such as local experience, capability to bring favorable financing, liability coverage, general background, potential and organizational structures. The advantages and disadvantages for the Owner of the three contracting approaches can be briefly summarized as follows: Turnkey Approach - main advantages: all responsibilities rest in a Contractor or Consortium. Main disadvantages - limited project control by Owner and restricted local participation. For Split Package Contract Approach main advantage are more favorable financing conditions and increased local participation. Main disadvantage is the increased interface problems. For Multiple package Contract Approach main advantages are the opportunity to tailor the plant and maximum increase of local participation. Main disadvantages are maximum responsibility to the Owner due to interfaces and compatibility of systems and technologies. (author)

  10. Posterior approach to ventrally located spinal meningiomas

    OpenAIRE

    Voulgaris, Spyridon; Alexiou, George A.; Mihos, Evaggelos; Karagiorgiadis, Dimitrios; Zigouris, Andreas; Fotakopoulos, George; Drosos, Dimitrios; Pahaturidis, Dimitrios

    2010-01-01

    For the resection of anteriorly located meningiomas, various approaches have been used. Posterior approach is less invasive and demanding; however, it has been associated with increased risk of spinal cord injury. We evaluated ten consecutive patients that underwent surgery for spinal meningiomas. All patients were preoperative assessed by neurological examination, computed tomography and magnetic resonance imaging. All tumors were ventrally located and removed via a posterior approach. Trans...

  11. Approaches for Categorization of Reusable Software Components

    OpenAIRE

    Sandhu, Parvinder S.; Janpreet Singh; Hardeep Singh

    2007-01-01

    Reuse repositories manager manages the reusable software components in different categories and needs to find the category of reusable software components. In this paper, we have used different pure and hybrid approaches to find the domain relevancy of the component to a particular domain. Probabilistic Latent Semantic Analysis (PLSA) approach, LSA, Singular Value Decomposition (SVD) technique, LSA Semi-Discrete Matrix Decomposition (SDD) technique and Naive Bayes Approach purely as well as h...

  12. The rehabilitative approach in rheumatoid arthritis

    OpenAIRE

    N. Pappone; S. Maddali Bongi; G. Arioli

    2011-01-01

    The rehabilitative approach for the patient with rheumatoid arthritis should be early, global and complementary to an early pharmacological therapy, in the context of a multidisciplinary approach, that should include physicians with different specialties and other health professionals. Evaluation scales assessing disability and quality of life are necessary for the rehabilitative approach. These can be classified in 2 groups: specific tools and generic tools, each evaluating different compone...

  13. Approach Merotopies and Associated Near Sets

    Directory of Open Access Journals (Sweden)

    James Peters

    2013-04-01

    Full Text Available This article introduces associated near sets of a collection of sets. The proposed approach introduces a means of defining as well as describing an ?-approach merotopy in terms of the members of associated sets of collections that are sufficiently near. A characterization for continuous functions is established using associated near sets. This article also introduces p-containment considered in the context of near sets. An application of the proposed approach is given in terms of digital image classification.

  14. A Learning Approach to Shallow Parsing

    OpenAIRE

    Muñoz, Marcia; Punyakanok, Vasin; Roth, Dan; Zimak, Dav

    2000-01-01

    A SNoW based learning approach to shallow parsing tasks is presented and studied experimentally. The approach learns to identify syntactic patterns by combining simple predictors to produce a coherent inference. Two instantiations of this approach are studied and experimental results for Noun-Phrases (NP) and Subject-Verb (SV) phrases that compare favorably with the best published results are presented. In doing that, we compare two ways of modeling the problem of learning t...

  15. Information Security Awareness: An Innovation Approach

    OpenAIRE

    Corona, Carlos Orozco

    2010-01-01

    Scholars and security practitioners seem to converge in the understanding that Information Security is in great part a problem about people; hence the need for a more holistic approach in order to understand human behaviour in the Information Security field which requires a multidisciplinary approach. Recent events such as the “Interdisciplinary Workshop on Security and Human Behaviour” hosted in Boston, Massachusetts in June 2008, are considering this approach and they have conveyed a m...

  16. A Unified Approach to Modeling and Programming

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann; MØller-Pedersen, Birger

    2010-01-01

    SIMULA was a language for modeling and programming and provided a unied approach to modeling and programming in contrast to methodologies based on structured analysis and design. The current development seems to be going in the direction of separation of modeling and programming. The goal of this paper is to go back to the future and get inspiration from SIMULA and propose a unied approach. In addition to reintroducing the contributions of SIMULA and the Scandinavian approach to object-oriented programming, we do this by discussing a number of issues in modeling and programming and argue3 why we consider a unied approach to be an advantage.

  17. EPN-Based Web Service Composition Approach

    Science.gov (United States)

    Gao, Min; Wu, Zhongfu

    Web service composition is highly significant for the efficiency of software development in service-oriented architecture (SOA). Till now, most PN-based composition approaches are based on HPN (High Level Petri Net), but the resources of HPN are not suitable for web services. It leads to the inefficiency of those composition approaches. This paper presents a novel approach based on EPN (Elementary Petri Net) to the issue. The research has adapted EPN to device a method to model web services in order to facilitate the composition by an automatic process which is controlled by transition rules and conditions. Finally, an example is given to validate the applicability of the composition approach.

  18. Hopf bifurcation analysis a frequency domain approach

    CERN Document Server

    Moiola, Jorge L

    1996-01-01

    This book is devoted to the frequency domain approach, for both regular and degenerate Hopf bifurcation analyses. Besides showing that the time and frequency domain approaches are in fact equivalent, the fact that many significant results and computational formulas obtained in the studies of regular and degenerate Hopf bifurcations from the time domain approach can be translated and reformulated into the corresponding frequency domain setting, and be reconfirmed and rediscovered by using the frequency domain methods, is also explained. The description of how the frequency domain approach can b

  19. Global energy modeling - A biophysical approach

    Energy Technology Data Exchange (ETDEWEB)

    Dale, Michael

    2010-09-15

    This paper contrasts the standard economic approach to energy modelling with energy models using a biophysical approach. Neither of these approaches includes changing energy-returns-on-investment (EROI) due to declining resource quality or the capital intensive nature of renewable energy sources. Both of these factors will become increasingly important in the future. An extension to the biophysical approach is outlined which encompasses a dynamic EROI function that explicitly incorporates technological learning. The model is used to explore several scenarios of long-term future energy supply especially concerning the global transition to renewable energy sources in the quest for a sustainable energy system.

  20. Phobos Sample Return: Next Approach

    Science.gov (United States)

    Zelenyi, Lev; Martynov, Maxim; Zakharov, Alexander; Korablev, Oleg; Ivanov, Alexey; Karabadzak, George

    The Martian moons still remain a mystery after numerous studies by Mars orbiting spacecraft. Their study cover three major topics related to (1) Solar system in general (formation and evolution, origin of planetary satellites, origin and evolution of life); (2) small bodies (captured asteroid, or remnants of Mars formation, or reaccreted Mars ejecta); (3) Mars (formation and evolution of Mars; Mars ejecta at the satellites). As reviewed by Galimov [2010] most of the above questions require the sample return from the Martian moon, while some (e.g. the characterization of the organic matter) could be also answered by in situ experiments. There is the possibility to obtain the sample of Mars material by sampling Phobos: following to Chappaz et al. [2012] a 200-g sample could contain 10-7 g of Mars surface material launched during the past 1 mln years, or 5*10-5 g of Mars material launched during the past 10 mln years, or 5*1010 individual particles from Mars, quantities suitable for accurate laboratory analyses. The studies of Phobos have been of high priority in the Russian program on planetary research for many years. Phobos-88 mission consisted of two spacecraft (Phobos-1, Phobos-2) and aimed the approach to Phobos at 50 m and remote studies, and also the release of small landers (long-living stations DAS). This mission implemented the program incompletely. It was returned information about the Martian environment and atmosphere. The next profect Phobos Sample Return (Phobos-Grunt) initially planned in early 2000 has been delayed several times owing to budget difficulties; the spacecraft failed to leave NEO in 2011. The recovery of the science goals of this mission and the delivery of the samples of Phobos to Earth remain of highest priority for Russian scientific community. The next Phobos SR mission named Boomerang was postponed following the ExoMars cooperation, but is considered the next in the line of planetary exploration, suitable for launch around 2022. A possible scenario of the Boomerang mission includes the approach to Deimos prior to the landing of Phobos. The needed excess ?V w.r.t. simple scenario (elliptical orbit à near-Phobos orbit) amounts to 0.67 km s-1 (1.6 vs 0.93 km s-1). The Boomerang mission basically repeats the Phobos-SR (2011) architecture, where the transfer-orbiting spacecraft lands on the Phobos surface and a small return vehicle launches the return capsule to Earth. We consider the Boomerang mission as an important step in Mars exploration and a direct precursor of Mars Sample Return. The following elements of the Boomerang mission might be directly employed, or serve as the prototypes for the Mars Sample return in future: Return vehicle, Earth descent module, Transfer-orbital spacecraft. We urge the development of this project for its high science value and recognize its elements as potential national contribution to an international Mars Sample Return project. Galimov E.M., Phobos sample return mission: scientific substantiation, Solar System Res., v.44, No.1, pp5-14, 2010. Chappaz L., H.J. Melosh, M. Vaguero, and K.C. Howell, Material transfer from the surface of Mars to Phobos and Deimos, 43rd Lunar and planetary Science Conference, paper 1422, 2012.

  1. Current chemotherapeutic approaches for hepatoblastoma.

    Science.gov (United States)

    Watanabe, Kenichiro

    2013-12-01

    Cisplatin-based chemotherapy has markedly improved the survival of patients with standard-risk hepatoblastoma (HB). However, treatment results for patients with metastatic disease remain unsatisfactory. As a result, the current therapeutic strategy for HB is to decrease dose intensity for standard-risk tumors in order to reduce chemotherapy-related toxicity and to intensify chemotherapy in combination with new drugs to develop new therapies and improve the outcome of patients with metastatic disease. Results from various trials of The North American Cooperative Study demonstrated that patients with localized disease achieved long-term survival following treatment with a combination of cisplatin, 5-fluorouracil, and vincristine (C5V). In the ongoing Children's Oncology Group (COG) trial, AHEP0731, patients with stage I pure fetal histology are classified as very low risk and treated with resection only, and patients with any stage IV disease or any stage plus an alpha-fetoprotein level at diagnosis of <100 ng/ml are classified as high risk and receive up-front window therapy followed by C5V + doxorubicin in an attempt to discover novel efficacious agents. The early International Childhood Liver Tumors Strategy Group (SIOPEL) trial, SIOPEL-1, demonstrated that a combination of cisplatin + doxorubicin (PLADO) is effective. In the SIOPEL-3SR trial, cisplatin alone was proved to be non-inferior to PLADO for standard-risk HB. In the SIOPEL-4 trial, intensified preoperative cisplatin was administered on a weekly basis, and this approach achieved the highest survival rate ever reported for patients, even those with metastatic disease. SIOPEL, COG, and the Japanese Study Group for Pediatric Liver Tumor (JPLT) have established the Children's Hepatoma International Collaboration (CHIC) to create a common risk classification and initiate international clinical trials in order to further improve the outcome of children with HB. PMID:24052132

  2. Approaches for improving cancer radiotherapy

    International Nuclear Information System (INIS)

    Radiation and cancer are intricately related. Radiotherapy, either alone or in combination with surgery and/or chemotherapy, is used for treatment of 60% of cancers. It will continue to be the mainstay for multi-modality treatment protocols unit new molecular therapies can be developed and brought to the stage of clinical trials. It will continue to be relevant thereafter, to compare the efficacy and cost effectiveness of the novel drugs under development. And it could also be useful as an adjuvant therapy, to augment the effects of novel drugs, at optimum dose levels. However, radiation is a well documented carcinogenic agent. Several studies have shown a statistically significant, though small enhancement in the risk of second malignancies, particularly in long-term survivors. The above discussions suggest that it is imperative to carry out preclinical radiobiological research for increasing tumor cell damage, while reducing the effective radiation doses. Development of radiobiological research programs in our institutions of higher learning such as post graduate medical institutions, cancer centers and universities could lead to the generation of a wealth of radiobiological data with potential clinical applications. Radiobiologists could utilize the infra-structure such as expensive radiotherapy equipment as well as clinical materials. For example, tumour biopsies readily available in the medical and cancer centers. However, if these studies have clinically meaningful implications it will be important to facilitate very close interactions between the basic scientists and clinicians. Some of the approaches for improving radiotherapy of cancer will be very briefly reviewed. Our current work about the effects of radiation-drug and drug-drug interactions for increasing cellular damage and death in brain tumor cells will also be presented. (author)

  3. Personalized medicine approaches in epilepsy.

    Science.gov (United States)

    Walker, L E; Mirza, N; Yip, V L M; Marson, A G; Pirmohamed, M

    2015-02-01

    Epilepsy affects 50 million persons worldwide, a third of whom continue to experience debilitating seizures despite optimum anti-epileptic drug (AED) treatment. Twelve-month remission from seizures is less likely in female patients, individuals aged 11-36 years and those with neurological insults and shorter time between first seizure and starting treatment. It has been found that the presence of multiple seizures prior to diagnosis is a risk factor for pharmacoresistance and is correlated with epilepsy type as well as intrinsic severity. The key role of neuroinflammation in the pathophysiology of resistant epilepsy is becoming clear. Our work in this area suggests that high-mobility group box 1 isoforms may be candidate biomarkers for treatment stratification and novel drug targets in epilepsy. Furthermore, transporter polymorphisms contributing to the intrinsic severity of epilepsy are providing robust neurobiological evidence on an emerging theory of drug resistance, which may also provide new insights into disease stratification. Some of the rare genetic epilepsies enable treatment stratification through testing for the causal mutation, for example SCN1A mutations in patients with Dravet's syndrome. Up to 50% of patients develop adverse reactions to AEDs which in turn affects tolerability and compliance. Immune-mediated hypersensitivity reactions to AED therapy, such as toxic epidermal necrolysis, are the most serious adverse reactions and have been associated with polymorphisms in the human leucocyte antigen (HLA) complex. Pharmacogenetic screening for HLA-B*15:02 in Asian populations can prevent carbamazepine-induced Stevens-Johnson syndrome. We have identified HLA-A*31:01 as a potential risk marker for all phenotypes of carbamazepine-induced hypersensitivity with applicability in European and other populations. In this review, we explore the currently available key stratification approaches to address the therapeutic challenges in epilepsy. PMID:25338670

  4. Lignin Sulfonation - A different Approach

    DEFF Research Database (Denmark)

    BjØrkmann, Anders

    2001-01-01

    The research on sulfite pulping has been characterized by the attempts to explain its chemistry. The. different approach presented is incited by perceptions about the (still) unsolved problem of the ultrastructural features of lignin in wood. A simple kinetic model has been chosen to describe the reaction order of lignin as "concentration" (weight) in the dissolution kinetics, the cooking liquor being used in substantial excess. Three states of lignin were used: in wood as sawdust (W), in milled. wood (MW) and as milled wood lignin (MWL). Cooks were performed at pH 1.5, and 6. (measured at room temperature). The lignin was also modified chemically in two ways: alkaline borohydride reduction and diazomethane methylation. The reaction order (with the kinetics used) was found to be about 2/3, which is the value to be expected for particles of equal size reacting, at the particle surface. The cooks were carried onto completion, defined as the maximum amount of dissolved lignin. Depending on the state of lignin, apart dissolved more or less "immediately". The kinetic results are presented in dissolution/time and Arrhenius diagrams. Some experiments were made to ensure that counterfeit results were evaded. It was found that lignin is very reactive, that is why the sulfonation chemistry alone does not necessarily determine its dissolution rate. It became evident that the ultrastructure dispersion of lignin in wood is beneficial for its dissolution. For W, the rate was much higher at pH 1.5 than at 6. MW lignin and MWL dissolved (after extraction of the "immediate" lignin) at higher rates than W lignin. For MWL, the rate difference between pH 1.5 and 6 was moderate, compared to W lignin. Borohydride reduction did not affect the lignin dissolution from W, but gave a large decrease of sulfonation rate for MWL. Methylation had also a small rate effect for W, but again a large decrease for MWL.

  5. Approach to autism spectrum disorder

    Science.gov (United States)

    Lee, Patrick F.; Thomas, Roger E.; Lee, Patricia A.

    2015-01-01

    Objective To review the diagnostic criteria for autism spectrum disorder (ASD) from the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V), and to develop an approach to managing ASD using the CanMEDS– Family Medicine (CanMEDS-FM) framework. Sources of information The DSM-V from the American Psychiatric Association, published in May 2013, provides new diagnostic criteria for ASD. The College of Family Physicians of Canada’s CanMEDS-FM framework provides a blueprint that can guide the complex management of ASD. We used data from the Centers for Disease Control and Prevention to determine the prevalence of ASD, and we used the comprehensive systematic review and meta-analysis completed by the UK National Institute for Health and Care Excellence for their guidelines on ASD to assess the evidence for more than 100 interventions. Main message The prevalence of ASD was 1 in 88 in 2008 in the United States according to data from the Centers for Disease Control and Prevention. The ASD classification in the fourth edition of the DSM included autism, Asperger syndrome, pervasive developmental disorder, and childhood disintegrative disorder. The new DSM-V revision incorporates all these disorders into one ASD umbrella term with different severity levels. The management of ASD is complex and requires a multidisciplinary team effort and continuity of care. The CanMEDS-FM roles provide a framework for management. Conclusion Family physicians are the key leaders of the multidisciplinary care team for ASD, and the CanMEDS-FM framework provides a comprehensive guide to help manage a child with ASD and to help the child’s family. PMID:25971758

  6. Quality Products - The CANDU Approach

    International Nuclear Information System (INIS)

    The prime focus of the CANDU concept (natural uranium fuelled-heavy water moderated reactor) from the beginning has economy, heavy water losses and radiation exposures also were strong incentives for ensuring good design and reliable equipment. It was necessary to depart from previously accepted commercial standards and to adopt those now accepted in industries providing quality products. Also, through feedback from operating experience and specific design and development programs to eliminate problems and improve performance, CANDU has evolved into today's successful product and one from which future products will readily evolve. Many lessons have been learned along the way. On the one hand, short cuts of failures to understand basic requirements have been costly. On the other hand, sound engineering and quality equipment have yielded impressive economic advantages through superior performance and the avoidance of failures and their consequential costs. The achievement of lifetime economical performance demands quality products, good operation and good maintenance. This paper describes some of the basic approaches leading to high CANDU station reliability and overall excellent performance, particularly where difficulties have had to be overcome. Specific improvements in CANDU design and in such CANDU equipment as heat transport pumps, steam generators, valves, the reactor, fuelling machines and station computers, are described. The need for close collaboration among d. The need for close collaboration among designers, nuclear laboratories, constructors, operators and industry is discussed. This paper has reviewed some of the key components in the CANDU system as a means of indicating the overall effort that is required to provide good designs and highly reliable equipment. This has required a significant investment in people and funding which has handsomely paid off in the excellent performance of CANDU stations. The close collaboration between Atomic Energy of Canada Limited, Canadian industry and the Canadian utilities has been the most important factor in this success

  7. Overview of Approach to 'Victoria'

    Science.gov (United States)

    2006-01-01

    [figure removed for brevity, see original site] Figure 1 This image from the Mars Orbiter Camera aboard NASA's Mars Global Surveyor spacecraft shows an overview of 'Victoria Crater' and a portion of the area NASA's Mars Exploration Rover Opportunity has covered to reach the enormous depression. Images such as this one from the Mars Orbiter Camera on NASA's Mars Global Surveyor are helping scientists and engineers decide the best path for NASA's Mars Exploration Rover Opportunity as it approaches 'Victoria Crater.' In figure 1, a blue dot indicates 'Cape Verde' and a red dot 'Cabo Frio.' These two points mark the extent of the crater visible from the rover's position on its 945th Martian day, or sol (Sept. 20, 2006), a location it had reached two sols earlier and from which much of this monster depression was still out of sight. The green annotations indicate 'Duck Bay,' a location expected to allow a view to the other side of the crater. A dune, or ripple, is to the left of the crater, right in front of the green dot location. This is where the team initially talked about sending Opportunity for the rover's first view down into the crater. After further consideration, the team opted for a drive to the right of that ripple (south of the green dot) near the rim. The yellow lines that surround and intersect Victoria Crater are used to measure the crater and the distance to the far 'bays.' North is up. Victoria Crater is about 800 meters (half a mile) in diameter.

  8. Biotechnology approaches to rice improvement

    International Nuclear Information System (INIS)

    Modern rice varieties developed at the International Rice Research Institute and by the National Rice Improvement Programs have had a dramatic impact on the increase in rice production. World rice production has doubled within a 25 year period, from 257 million tonnes in 1966 to 520 million tonnes in 1990, and most of the rice growing countries in Asia have attained self-sufficiency. However, the population of rice eaters continues to increase at an alarming rate and the demand for rice is likely to exceed production by the end of this century. To meet this demand in the next century, rice varieties are needed with a higher yield potential, multiple resistance to diseases and insects, and tolerance to abiotic stresses. Recent breakthroughs in cellular and molecular genetics have provided tools that can increase the efficiency of breeding methods and allow unconventional approaches to rice improvement. Application of these tools will permit us to develop improved rice varieties for meeting the challenges of increased rice production. Some of the exciting developments in rice biotechnology include: successful regeneration from protoplasts of japonica and indica rices; production of transgenic plants; development of a comprehensive molecular map consisting of more than 1500 DNA markers; tagging of genes of economic importance with restriction fragment length polymorphism markers; molecular characterization of pathogen populations based on restriction fragment patterns; a based on restriction fragment patterns; and transfer of genes from wild species across crossability barriers. Thus, anther culture, marker aided selection and molecular analysis of pathogen populations are being employed to improve the efficiency of conventional rice breeding. Wide hybridization, protoplast fusion and transformation permit us to introduce nove genes into rice. (author). 54 refs, 2 figs

  9. Three Approaches to Classical Thermal Field Theory

    CERN Document Server

    Gozzi, E

    2010-01-01

    In this paper we study three different functional approaches to classical thermal field theory, which turn out to be the classical counterparts of three well-known different formulations of quantum thermal field theory: the Closed-Time Path (CTP) formalism, the Thermofield Dynamics (TFD) and the Matsubara approach.

  10. Three approaches to classical thermal field theory

    Science.gov (United States)

    Gozzi, E.; Penco, R.

    2011-04-01

    In this paper we study three different functional approaches to classical thermal field theory, which turn out to be the classical counterparts of three well-known different formulations of quantum thermal field theory: the closed-time path (CTP) formalism, the thermofield dynamics (TFD) and the Matsubara approach.

  11. Evaluation and Opportunities in Overtraining Approaches

    Science.gov (United States)

    Roose, Jolanda; de Vries, Wouter R.; Schmikli, Sandor L.; Backx, Frank J. G.; van Doornen, Lorenz J. P.

    2009-01-01

    Overtraining (OT) as a sports phenomenon can be caused by stressors on various levels (physical, emotional, psychological, and social) and evokes responses on these levels. This study evaluated research and new opportunities in the field of OT by introducing an integrated multidisciplinary approach, based on the single and multistressors approach

  12. A pragmatic Bayesian approach to predictive uncertainty

    OpenAIRE

    Murray, Iain; Snelson, Edward

    2006-01-01

    We describe an approach to regression based on building a probabilistic model with the aid of visualization. The “stereopsis” data set in the predictive uncertainty challenge is used as a case study, for which we constructed a mixture of neural network experts model. We describe both the ideal Bayesian approach and computational shortcuts required to obtain timely results.

  13. The 'Whole Diet' Approach to Nutrition

    Medline Plus

    Full Text Available ... Diet_022315.html The 'Whole Diet' Approach to Nutrition HealthDay News Video - February 23, 2015 To use ... JavaScript. Play video: The 'Whole Diet' Approach to Nutrition For closed captioning, click the CC button on ...

  14. The 'Whole Diet' Approach to Nutrition

    Medline Plus

    Full Text Available ... videos/news/Whole_Diet_022315.html The 'Whole Diet' Approach to Nutrition HealthDay News Video - February 23, ... page, please enable JavaScript. Play video: The 'Whole Diet' Approach to Nutrition For closed captioning, click the ...

  15. Dossier "Gender and rights-based approaches"

    OpenAIRE

    2011-01-01

    Can rights-based approaches forward the development agenda of gender equality? This dossier aims to address this question focusing on the application of rights-based approaches, and in particular their use in programmes and interventions that work towards achieving gender equality.

  16. A New Approach to Classical Statistical Mechanics

    OpenAIRE

    Nijalingappa Umakantha

    2011-01-01

    A new approach to classical statistical mechanics is presented; this is based on a new method of specifying the possible “states” of the systems of a statistical assembly and on the relative frequency interpretation of probability. This approach is free from the concept of ensemble, the ergodic hypothesis, and the assumption of equal a priori probabilities.

  17. A Linear Algebraic Approach to Teaching Interpolation

    Science.gov (United States)

    Tassa, Tamir

    2007-01-01

    A novel approach for teaching interpolation in the introductory course in numerical analysis is presented. The interpolation problem is viewed as a problem in linear algebra, whence the various forms of interpolating polynomial are seen as different choices of a basis to the subspace of polynomials of the corresponding degree. This approach…

  18. A New Approach to Classical Statistical Mechanics

    Directory of Open Access Journals (Sweden)

    Nijalingappa Umakantha

    2011-11-01

    Full Text Available A new approach to classical statistical mechanics is presented; this is based on a new method of specifying the possible “states” of the systems of a statistical assembly and on the relative frequency interpretation of probability. This approach is free from the concept of ensemble, the ergodic hypothesis, and the assumption of equal a priori probabilities.

  19. An Experiential Approach to Cultural Intelligence Education

    Science.gov (United States)

    MacNab, Brent R.

    2012-01-01

    Cultural intelligence (CQ) represents a promising advancement in the area of cross-cultural training and management. Experiential approaches for CQ development have been proposed as highly effective; however, there is a lack of CQ-specific approaches in the management literature. This work overviews the concept of cultural intelligence and its…

  20. The 'Whole Diet' Approach to Nutrition

    Medline Plus

    Full Text Available ... news/Whole_Diet_022315.html The 'Whole Diet' Approach to Nutrition HealthDay News Video - February 23, 2015 ... please enable JavaScript. Play video: The 'Whole Diet' Approach to Nutrition For closed captioning, click the CC ...

  1. An Aboriginal Worldview of Helping: Empowering Approaches.

    Science.gov (United States)

    Poonwassie, Anne; Charter, Ann

    2001-01-01

    Examines how Aboriginal groups and communities have taken leadership by developing their own holistic approaches to healing/wellness, based on their worldviews. Argues that a reflection on this process with an awareness of Aboriginal worldviews and cultural imperatives offers possible approaches that facilitate empowerment in working with…

  2. A Novel Approach to Teaching Teamwork

    Science.gov (United States)

    Drake, Robert; Goldsmith, Geraldine; Strachan, Rebecca

    2006-01-01

    Teamwork is widely recognised as an important skill both generally and in the context of the computing industry. The majority of approaches to teaching teamwork are "practically" based and in higher education are often designed to run over a number of weeks. We required an approach that would work over a concentrated period of five days during the…

  3. Computational Approaches for Predicting Biomedical Research Collaborations

    OpenAIRE

    Zhang, Qing; YU, HONG

    2014-01-01

    Biomedical research is increasingly collaborative, and successful collaborations often produce high impact work. Computational approaches can be developed for automatically predicting biomedical research collaborations. Previous works of collaboration prediction mainly explored the topological structures of research collaboration networks, leaving out rich semantic information from the publications themselves. In this paper, we propose supervised machine learning approaches to predict researc...

  4. An Agile Course-Delivery Approach

    Science.gov (United States)

    Capellan, Mirkeya

    2009-01-01

    In the world of software development, agile methodologies have gained popularity thanks to their lightweight methodologies and flexible approach. Many advocates believe that agile methodologies can provide significant benefits if applied in the educational environment as a teaching method. The need for an approach that engages and motivates…

  5. Approaches to psychiatric nosology: A viewpoint

    OpenAIRE

    Avasthi, Ajit; Sarkar, Siddharth; Grover, Sandeep

    2014-01-01

    Psychiatric nosology is required for communication among clinicians and researchers, understanding etiology, testing treatment efficacy, knowing the prevalence of the problems and disorders, healthcare planning, organizing the services, and reimbursement purposes. Many approaches have been used for psychiatric nosology, including categorical, dimensional, hybrid, and etiological. The categorical approach considers illness as being either present or absent, and similarity with prototypical des...

  6. A constructive approach to gene expression dynamics

    International Nuclear Information System (INIS)

    Recently, experiments on mRNA abundance (gene expression) have revealed that gene expression shows a stationary organization described by a scale-free distribution. Here we propose a constructive approach to gene expression dynamics which restores the scale-free exponent and describes the intermediate state dynamics. This approach requires only one assumption: Markov property

  7. Physical approach to complex systems

    Science.gov (United States)

    Kwapie?, Jaros?aw; Dro?d?, Stanis?aw

    2012-06-01

    Typically, complex systems are natural or social systems which consist of a large number of nonlinearly interacting elements. These systems are open, they interchange information or mass with environment and constantly modify their internal structure and patterns of activity in the process of self-organization. As a result, they are flexible and easily adapt to variable external conditions. However, the most striking property of such systems is the existence of emergent phenomena which cannot be simply derived or predicted solely from the knowledge of the systems’ structure and the interactions among their individual elements. This property points to the holistic approaches which require giving parallel descriptions of the same system on different levels of its organization. There is strong evidence-consolidated also in the present review-that different, even apparently disparate complex systems can have astonishingly similar characteristics both in their structure and in their behaviour. One can thus expect the existence of some common, universal laws that govern their properties. Physics methodology proves helpful in addressing many of the related issues. In this review, we advocate some of the computational methods which in our opinion are especially fruitful in extracting information on selected-but at the same time most representative-complex systems like human brain, financial markets and natural language, from the time series representing the observables associated with these systems. The properties we focus on comprise the collective effects and their coexistence with noise, long-range interactions, the interplay between determinism and flexibility in evolution, scale invariance, criticality, multifractality and hierarchical structure. The methods described either originate from “hard” physics-like the random matrix theory-and then were transmitted to other fields of science via the field of complex systems research, or they originated elsewhere but turned out to be very useful also in physics - like, for example, fractal geometry. Further methods discussed borrow from the formalism of complex networks, from the theory of critical phenomena and from nonextensive statistical mechanics. Each of these methods is helpful in analyses of specific aspects of complexity and all of them are mutually complementary.

  8. Probabilistic Approaches to Energy Systems

    DEFF Research Database (Denmark)

    Iversen, Jan Emil Banning

    2015-01-01

    Energy generation from wind and sun is increasing rapidly in many parts of the world. This presents new challenges on how to integrate this uncertain, intermittent and non-dispatchable energy source. This thesis deals with forecasting and decision making in energy systems with a large proportion of renewable energy generation. Particularly we focus on producing forecasting models that can predict renewable energy generation, single user demand, and provide advanced forecast products that are needed for an efficient integration of renewable energy into the power generation mix. Such forecasts can be useful on all levels of the energy systems, ranging from the highest level, where the transmission system operator is concerned with minimizing system failures and is aided by wind power forecasts, to the end user of energy where power price forecasts are useful for users with flexible power demand. The main contributions of this thesis lie in the realm of using gray box models to produce forecasts for energysystems. Gray box models can be defined as a crossover between physical models (or white box models), that base their model on a physical understanding of the system at hand, and data driven models (or black box models) that focus on accurately describing the data without considering physical limitations of the system. Integrating these physical structures into a data driven approach allows for producing better forecasts with more accurate predictions. In this thesis we have developed and applied methodologies for gray box modeling to produce forecasts for vehicle driving patterns, solar irradiance, wind speeds, wind power, and solar power. The model for driving patterns has subsequently been used as input into an optimization algorithm for charging a single electric vehicle. In a subsequent study the behavior of a fleet of electric vehicles has been studied. In the thesis we go through various examples of forecasts products and their applications. We emphasize that forecasting can not stand alone and should be complimented by optimization and decision making tools for an efficient integration of renewable energy.Thus forecast products should be developed in unison with the decision making tool as they are two sides of the same overall challenge.

  9. Broader approach to fusion energy

    International Nuclear Information System (INIS)

    The European Atomic Energy Community (EURATOM) and the Japanese government signed an agreement for ''the Joint Implementation of the Broader Approach Activities in the Field of Fusion Energy Research'' on 5th February 2007. The Agreement is expected to enter into force before the end of this year. This co-operation aims at complementing the ITER project and at an early realization of fusion energy by carrying out R and D and developing some advanced technologies for the future demonstration power reactor (DEMO). Three research projects will be undertaken in Japan under the framework of this agreement; 1. Engineering Validation and Engineering Design Activities for the International Fusion Materials Irradiation Facility (IFMIF/EVEDA). IFMIF will allow testing and qualification of advanced materials in an environment similar to that of a future fusion power plant. The Engineering Validation and Engineering Design Activities aim at producing a detailed, complete and fully integrated engineering design of IFMIF. 2. International Fusion Energy Research Centre (IFERC). The missions of the IFERC include the co-ordination of DEMO Design and R and D activities, large scale simulation activities of fusion plasmas by super-computer and remote experimentation activities to facilitate a broad participation of scientists into ITER experiments. 3. Satellite Tokamak Programme The JT-60 tokamak will be upgraded to an advanced superconducting tokamak JT-60 SA, and be exploited as a ''sokamak JT-60 SA, and be exploited as a ''satellite'' facility to ITER. The Satellite Tokamak Programme is expected to develop operating scenarios and address key physics issues for an efficient start up of ITER and in order to provide a continuous support to ITER experimentation and to advance research towards DEMO. While the Satellite Tokamak Programme will be conducted at the existing JT-60 tokamak site in Naka, the IFMIF-EVEDA and the IFERC projects will be carried out at Rokkasho, Aomori. A new research site is being prepared for these two projects at the same site proposed for ITER. The construction of the buildings is to be started during this year and completed within two years. Preparatory work has been started such as the joint planning on the IFERC and the IFMIF-EVEDA, and the technical review of the conceptual design of JT- 60SA. As soon as the Agreement will be in force, EURATOM and Japan will adopt the project plans for the three projects to be able to implement them without delay. (orig.)

  10. Biotechnology Approaches to Life Detection

    Science.gov (United States)

    Steele, Andrew; McKay, David; Schweitzer, Mary

    2001-01-01

    The direct detection of organic biomarkers for living or fossil microbes on Mars by an in situ instrument is a worthy goal for future lander missions. Several new and innovative biotechnology approaches are being explored. Firstly we have proposed an instrument based on immunological reactions to specific antibodies to cause activation of fluorescent stains. Antibodies are raised or acquired to a variety of general and specific substances that might be in Mars soil. These antibodies are then combined with various fluorescent stains and applied to micron sized numbered spots on a small (2-3 cm) test plate where they become firmly attached after freeze drying. Using technology that has been developed for gene mining in DNA technology up to 10,000 tests per square inch can now be applied to a test plate. On Mars or the planet/moon of interest, a sample of soil from a trench or drill core is extracted with water and/or an organic solvent and ultrasonication and then applied to the test plate. Any substance, which has an antibody on the test plate, will react with its antibody and activate its fluorescent stain. At the moment a small UV light source will illuminate the test plate, which is observed with a small CCD camera, although other detection systems will be applied. The numbered spots that fluoresce indicate the presence of the tested-for substance, and the intensity indicates relative amounts. Furthermore with up to a thousand test plates available false positives and several variations of antibody can also be screened for. The entire instrument can be quite small and light, on the order of 10 cm in each dimension. A possible choice for light source may be small UV lasers at several wavelengths. Some of the wells or spots can contain simply standard fluorescent stains used to detect live cells, dead cells, DNA, etc. The stains in these spots may be directly activated, with no antibodies being necessary. The proposed system will look for three classes of biomarkers: those from extant life, such as DNA, those from extinct life such as hopanes, and those from organic compounds not necessarily associated with life such as PAHs, rocket exhaust contamination and other a/pre-biotic chemicals. Both monoclonal and polyclonal antibodies can be used. Monoclonal antibodies react with a very specific compound, but polyclonal antibodies may react to any of a whole family of compounds. Furthermore the technique of phage display to raise antibodies against classically non-antigenic molecules is also being considered. Additional information is contained in the original extended abstract.

  11. Assessing global adoption of one health approaches.

    Science.gov (United States)

    Hueston, William; Appert, Jessica; Denny, Terry; King, Lonnie; Umber, Jamie; Valeri, Linda

    2013-09-01

    Transdisciplinary One Health (OH) approaches have been rediscovered as a promising tactic for addressing complex health risks at the human-animal-ecosystem interface. However, there is little evidence of widespread adoption of OH approaches as the new operating normal for addressing these complex health issues. We have used a transformational change model as an evaluation tool and part of an overall assessment of the global adoption of OH approaches. This assessment establishes a point of reference for measuring progress toward OH approaches being the new operating normal. Global adoption of OH approaches will require more strategic efforts to build the case (value proposition), recruiting a broader pool of One Health champions, solidifying partnerships and unifying OH efforts. PMID:23835604

  12. Index analysis approach theory at work

    CERN Document Server

    Lowen, R

    2015-01-01

    A featured review of the AMS describes the author’s earlier work in the field of approach spaces as, ‘A landmark in the history of general topology’. In this book, the author has expanded this study further and taken it in a new and exciting direction.   The number of conceptually and technically different systems which characterize approach spaces is increased and moreover their uniform counterpart, uniform gauge spaces, is put into the picture. An extensive study of completions, both for approach spaces and for uniform gauge spaces, as well as compactifications for approach spaces is performed. A paradigm shift is created by the new concept of index analysis.   Making use of the rich intrinsic quantitative information present in approach structures, a technique is developed whereby indices are defined that measure the extent to which properties hold, and theorems become inequalities involving indices; therefore vastly extending the realm of applicability of many classical results. The theory is the...

  13. The Norwegian approach to integrated quality development.

    Science.gov (United States)

    Ovretveit, J

    2001-01-01

    The UK NHS quality proposals require all NHS organisations to develop an "integrated approach " to quality. In other countries, health care organisations are also working to ensure that the many different quality methods and systems used in health organisations do not duplicate or conflict with each other. The question this paper addresses is "what would an integrated approach to quality look like and how might managers and clinicians develop such an approach in their organisation?" The findings from the Norwegian total quality management experiment in six hospitals were that TQM could not be applied in its pure form in public health care services to ensure integration. The paper draws on this research to describe these hospitals' approach to integrate the different projects and systems which were stimulated by their initial quality programmes. The paper describes the "integrated quality development" approach which characterised these programmes. PMID:11547821

  14. Valuation:from the discounted cash flows (DCF) approach to the real options approach (ROA)

    OpenAIRE

    Maya Ochoa, Cecilia

    2004-01-01

    There exists an abysm between market prices and traditional valuation approaches such as Discounted Cash Flows (DCF), a fact that neither academics nor practitioners could continue ignoring. Recently, a complementary approach has taken a foothold into the valuation world. Building on the DCF approach yet going further in the sense of incorporating flexibility in management investment decisions, and taking advantage of the advances in option pricing theory, the real options approach (ROA) has ...

  15. Asymptotic study of canonical correlation analysis: from matrix and analytic approach to operator and tensor approach

    OpenAIRE

    Fine, Jeanne

    2003-01-01

    Asymptotic study of canonical correlation analysis gives the opportunity to present the different steps of an asymptotic study and to show the interest of an operator and tensor approach of multidimensional asymptotic statistics rather than the classical, matrix and analytic approach. Using the last approach, Anderson (1999) assumes the random vectors to have a normal distribution and the non zero canonical correlation coefficients to be distinct. The new approach we use, Fine (2000), is coor...

  16. Hybrid biasing approaches for global variance reduction

    International Nuclear Information System (INIS)

    A new variant of Monte Carlo—deterministic (DT) hybrid variance reduction approach based on Gaussian process theory is presented for accelerating convergence of Monte Carlo simulation and compared with Forward-Weighted Consistent Adjoint Driven Importance Sampling (FW-CADIS) approach implemented in the SCALE package from Oak Ridge National Laboratory. The new approach, denoted the Gaussian process approach, treats the responses of interest as normally distributed random processes. The Gaussian process approach improves the selection of the weight windows of simulated particles by identifying a subspace that captures the dominant sources of statistical response variations. Like the FW-CADIS approach, the Gaussian process approach utilizes particle importance maps obtained from deterministic adjoint models to derive weight window biasing. In contrast to the FW-CADIS approach, the Gaussian process approach identifies the response correlations (via a covariance matrix) and employs them to reduce the computational overhead required for global variance reduction (GVR) purpose. The effective rank of the covariance matrix identifies the minimum number of uncorrelated pseudo responses, which are employed to bias simulated particles. Numerical experiments, serving as a proof of principle, are presented to compare the Gaussian process and FW-CADIS approaches in terms of the global reduction in standard deviation of the estimated responses. - Highlights: ? Hybrid Monte Carlo s. - Highlights: ? Hybrid Monte Carlo Deterministic Method based on Gaussian Process Model is introduced. ? Method employs deterministic model to calculate responses correlations. ? Method employs correlations to bias Monte Carlo transport. ? Method compared to FW-CADIS methodology in SCALE code. ? An order of magnitude speed up is achieved for a PWR core model.

  17. XV-15 Tiltrotor Low Noise Approach Operations

    Science.gov (United States)

    Conner, David A.; Marcolini, Michael A.; Decker, William A.; Cline, John H.; Edwards, Bryan D.; Nicks, Colby O.; Klein, Peter D.

    1999-01-01

    Acoustic data have been acquired for the XV-15 tiltrotor aircraft performing approach operations for a variety of different approach profile configurations. This flight test program was conducted jointly by NASA, the U.S. Army, and Bell Helicopter Textron, Inc. (BHTI) in June 1997. The XV-15 was flown over a large area microphone array, which was deployed to directly measure the noise footprint produced during actual approach operations. The XV-15 flew realistic approach profiles that culminated in IGE hover over a landing pad. Aircraft tracking and pilot guidance was provided by a Differential Global Positioning System (DGPS) and a flight director system developed at BHTI. Approach profile designs emphasized noise reduction while maintaining handling qualities sufficient for tiltrotor commercial passenger ride comfort and flight safety under Instrument Flight Rules (IFR) conditions. A discussion of the approach profile design philosophy is provided. Five different approach profiles are discussed in detail -- 3 deg., 6 deg., and 9 deg. approaches, and two very different 3 deg. to 9 deg. segmented approaches. The approach profile characteristics are discussed in detail, followed by the noise footprints and handling qualities. Sound exposure levels are also presented on an averaged basis and as a function of the sideline distance for a number of up-range distances from the landing point. A comparison of the noise contour areas is also provided. The results document the variation in tiltrotor noise due to changes in operating condition, and indicate the potential for significant noise reduction using the unique tiltrotor capability of nacelle tilt.

  18. Understanding the Montessori Approach: Early Years Education in Practice. Understanding the... Approach

    Science.gov (United States)

    Isaacs, Barbara

    2012-01-01

    "Understanding the Montessori Approach" is a much needed source of information for those wishing to extend and consolidate their understanding of the Montessori Approach and how it is used in the teaching and learning of young children. It will enable the reader to analyse the essential elements of this Approach to early childhood and and its…

  19. 33 CFR 167.502 - In the approaches to Los Angeles-Long Beach: Western approach.

    Science.gov (United States)

    2010-07-01

    ...2010-07-01 2010-07-01 false In the approaches to Los Angeles-Long Beach: Western approach. 167.502 Section 167.502 Navigation...Pacific West Coast § 167.502 In the approaches to Los Angeles-Long Beach: Western...

  20. NRTMA: Common purpose; complementary approaches

    International Nuclear Information System (INIS)

    Full text: Near Real Time Material Accountancy (NRTMA) is a leading edge technical solution to in- process verification in bulk handling facilities. It facilitates non-intrusive inspection and allows safeguards conclusions to be drawn without plant shut down. NRTMA is fully operational in the Thermal Oxide Reprocessing Plant (Thorp), providing regular assurance of high quality material control. At its core are a number of statistical algorithms to process the data. This paper covers the techniques deployed by BNFL and Euratom for NRTMA in the Thorp facility located at Sellafield. As early as 1982, a number of important decisions were taken by BNFL in support of safeguards. In addition to the pursuit of high precision measurement of nuclear materials flow, BNFL set out a comprehensive suite of instrumentation to allow frequent nuclear materials inventory determination and materials balancing. These instruments provide Euratom with a comprehensive set of plant-specific data in computerised form. The operator and the safeguards regulator have complementary requirements from the working NRTMA System for nuclear material control. BNFL requires uninterrupted operation whilst demonstrating full compliance with all regulations. In practice, this means that plutonium plants can remain operational between annual Physical Inventory Takings, and a system of early warnings and diagnostic indicators are available continuously to the operator and the inspectors. The Safeguards Inspectorate, of course, wants to be assured that there has been no diversion of plutonium, in line with safeguards goals. During commissioning, BNFL's NRTMA System has focused on identifying any underlying uncertainties in the measurements systems. Error components have been identified and quantified by anomaly resolution tools and by process investigations. This has been invaluable in identifying specific effects and in providing a running overview of plant accountancy performance. The NRTMA process models and methods for in-process inventory determination were further refined in this period. BNFL is now extending the NRTMA System to farther integrate remaining estimates of systematic uncertainties. Euratom's safeguards inspection scheme has taken advantage of the BNFL NRTMA System. From a verification point of view, NRTMA supports fulfilment of the monthly timeliness component of the safeguards approach. The flow component of the system is covered by extensive verification activities on a continuous inspection basis using a wide range of safeguards techniques such as process monitoring, C/S and independent safeguards equipment. Euratom and BNFL have worked in a spirit of co-operation, co-ordinated within a Framework Working Group. Provision of interim-inventories and the use of NRTMA were part of the criteria for European Commission approval of the safeguards techniques in the chemical plant reprocessing areas. These criteria and general terms of reference regarding the use of NRTMA were agreed between ESO and BNFL and recorded in a formal NRTMA Framework Document. The Data Evaluation Sector of ESO is the principal point of contact with BNFL on NRTMA statistical aspects. In order to evaluate NRTMA balances, a simplified process model was created by ESO, together with a related statistical model for the measurement errors and their propagation. It included the definition of particular testing variables suitable for safeguards anomaly detection, and sensitivity studies based on Monte Carlo simulations. ESO's need in evaluating the statistical analysis was to integrate the alarm probability level required with the assurance gained from other safeguards verifications, and maximise efficiency and effective use of inspector resources. The NRTMA data collection system fully supports interim inventory declaration. ESO consider alarms as being when all error components have been exceeded. The Inspectorate is routinely provided with interim inventory declarations at vessel level, in electronic form, and uses this to complement the BNFL analysis by conducting further sta

  1. Probabilistic approach to earthquake prediction.

    Directory of Open Access Journals (Sweden)

    G. D'Addezio

    2002-06-01

    Full Text Available The evaluation of any earthquake forecast hypothesis requires the application of rigorous statistical methods. It implies a univocal definition of the model characterising the concerned anomaly or precursor, so as it can be objectively recognised in any circumstance and by any observer.A valid forecast hypothesis is expected to maximise successes and minimise false alarms. The probability gain associated to a precursor is also a popular way to estimate the quality of the predictions based on such precursor. Some scientists make use of a statistical approach based on the computation of the likelihood of an observed realisation of seismic events, and on the comparison of the likelihood obtained under different hypotheses. This method can be extended to algorithms that allow the computation of the density distribution of the conditional probability of earthquake occurrence in space, time and magnitude. Whatever method is chosen for building up a new hypothesis, the final assessment of its validity should be carried out by a test on a new and independent set of observations. The implementation of this test could, however, be problematic for seismicity characterised by long-term recurrence intervals. Even using the historical record, that may span time windows extremely variable between a few centuries to a few millennia, we have a low probability to catch more than one or two events on the same fault. Extending the record of earthquakes of the past back in time up to several millennia, paleoseismology represents a great opportunity to study how earthquakes recur through time and thus provide innovative contributions to time-dependent seismic hazard assessment. Sets of paleoseimologically dated earthquakes have been established for some faults in the Mediterranean area: the Irpinia fault in Southern Italy, the Fucino fault in Central Italy, the El Asnam fault in Algeria and the Skinos fault in Central Greece. By using the age of the paleoearthquakes with their associated uncertainty we have computed, through a Montecarlo procedure, the probability that the observed inter-event times come from a uniform random distribution (null hypothesis. This probability is estimated approximately equal to 8.4% for the Irpinia fault, 0.5% for the Fucino fault, 49% for the El Asnam fault and 42% for the Skinos fault. So, the null Poisson hypothesis can be rejected with a confidence level of 99.5% for the Fucino fault, but it can be rejected only with a confidence level between 90% and 95% for the Irpinia fault, while it cannot be rejected for the other two cases. As discussed in the last section of this paper, whatever the scientific value of any prediction hypothesis, it should be considered effective only after evaluation of the balance between the costs and benefits introduced by its practical implementation.

  2. System test approach for the SAX satellite

    Science.gov (United States)

    Giordano, Pietro; Raimondo, Giacomo; Messidoro, Piero

    1992-11-01

    SAX satellite verification is based on a protoflight approach, in which only one system model is realized at flight standard level, taking into account the utilization of hardware already qualified for other space programs and the necessity to respect the schedule constraints for a scientific objective. In any case, this approach was tailored with some deviations in order to reduce risks inherent in such a choice. The protoflight approach was also pursued at subsystem/unit level in particular for those subsystems and units considered critical from the schedule point of view. Payload Instruments followed the same approach but complete spare units were developed to reduce the risks associated with such an approach. A description of the model philosophy is provided and then, at satellite level, the testing approach and rationale for each model is presented. Finally, a brief description of each test will be given, highlighting objectives, methodologies, and test configurations. Moreover, for the major tests, problems encountered and solutions applied in establishing a correct approach are described.

  3. A Dialectical Approach to Positive Organizational Studies

    Directory of Open Access Journals (Sweden)

    Miguel Pereira Lopes

    2013-04-01

    Full Text Available Over the last decade, an academic movement emerged towards the study of positive phenomena in management and organization studies. Since then, two different scientific research streams have emerged in line with this positive approach to management: 1 positive organizational scholarship (POS, which proposes a trait approach view of positive virtues and strengths and sees the environment as a moderator variable which facilitates or not the exhibition of corresponding positive behaviours; and positive organizational behaviour (POB, which defends a state-like perspective of positive characteristics, thus putting a strong emphasis on situational factors as determinants of positive behaviour, leaving a marginal role to positive psychological traits. As a critical comparison between these two different research streams is yet to be done, in this paper I propose a dialectical approach to study positivity in organizations and contrast these two different ontological approaches to positivity in organizations. I presented arguments to demonstrate that each of these approaches alone constitute quite a limited proposal in that each of them seems to misleadingly assume that: traits cannot be changed; they show incongruence between assumptions and purpose and; they constitute biased viewpoints. A dialectical approach makes possible to overcome these shortcomings by assuming both personality characteristics and environmental features relate each other in an intertwined complex way to produce positive behaviour in organizations. I finally present some practical implications that a dialectical approach would have to organizations and managers.

  4. Study strategies and approaches to learning

    DEFF Research Database (Denmark)

    Christensen, Hans Peter

    In this study students’ study strategies have been compared to their approaches to learning. The time students spend on different study activities has been investigated at the Technical University of Denmark, and as a pilot project a few students also filled in a reduced version of Bigg's Study Process Questionnaire to identify their approach to learning. It was hypothesised that the students’ learning approach would depend more on the quality of the study work than on the quantity; that an active and reflective study strategy was required to obtain deep conceptual understanding. The result showed a weak correlation between the student’s main learning approach as defined by the ratio of the deep approach score to the surface approach score and the student’s study intensity as identified by the ratio of non-scheduled independent activities to scheduled teacher-controlled activities. There was however a much stronger linear correlation (significant at the 0.01 level) between the deep-surface ratio and the totalstudy load. The same result was observed when measuring other students’ study strategy and learning approach for a single course. The empirical basis is still too limited to draw conclusive conclusions, but it raises some intriguing questions. Is time more important than the kind of learning activities for obtaining conceptual understanding – is all that matters from a teaching point of view to ensure that the students spend long hours studying?

  5. Radiotherapy problem under fuzzy theoretic approach

    International Nuclear Information System (INIS)

    A fuzzy set theoretic approach is used for radiotherapy problem. The problem is faced with two goals: the first is to maximize the fraction of surviving normal cells and the second is to minimize the fraction of surviving tumor cells. The theory of fuzzy sets has been employed to formulate and solve the problem. A linguistic variable approach is used for treating the first goal. The solutions obtained by the modified approach are always efficient and best compromise. A sensitivity analysis of the solutions to the differential weights is given

  6. Shell Model in a First Principles Approach

    Energy Technology Data Exchange (ETDEWEB)

    Navratil, P; Nogga, A; Lloyd, R; Vary, J P; Ormand, W E; Barrett, B R

    2004-01-08

    We develop and apply an ab-initio approach to nuclear structure. Starting with the NN interaction, that fits two-body scattering and bound state data, and adding a theoretical NNN potential, we evaluate nuclear properties in a no-core approach. For presently feasible no-core model spaces, we evaluate an effective Hamiltonian in a cluster approach which is guaranteed to provide exact answers for sufficiently large model spaces and/or sufficiently large clusters. A number of recent applications are surveyed including an initial application to exotic multiquark systems.

  7. Approaching Moons from Resonance via Invariant Manifolds

    Science.gov (United States)

    Anderson, Rodney L.

    2012-01-01

    In this work, the approach phase from the final resonance of the endgame scenario in a tour design is examined within the context of invariant manifolds. Previous analyses have typically solved this problem either by using numerical techniques or by computing a catalog of suitable trajectories. The invariant manifolds of a selected set of libration orbits and unstable resonant orbits are computed here to serve as guides for desirable approach trajectories. The analysis focuses on designing an approach phase that may be tied into the final resonance in the endgame sequence while also targeting desired conditions at the moon.

  8. A contingency table approach to nonparametric testing

    CERN Document Server

    Rayner, JCW

    2000-01-01

    Most texts on nonparametric techniques concentrate on location and linear-linear (correlation) tests, with less emphasis on dispersion effects and linear-quadratic tests. Tests for higher moment effects are virtually ignored. Using a fresh approach, A Contingency Table Approach to Nonparametric Testing unifies and extends the popular, standard tests by linking them to tests based on models for data that can be presented in contingency tables.This approach unifies popular nonparametric statistical inference and makes the traditional, most commonly performed nonparametric analyses much more comp

  9. A statistical approach to plasma profile analysis

    International Nuclear Information System (INIS)

    A general statistical approach to the parameterisation and analysis of tokamak profiles is presented. The modelling of the profile dependence on both the radius and the plasma parameters is discussed, and pertinent, classical as well as robust, methods of estimation are reviewed. Special attention is given to statistical tests for discriminating between the various models, and to the construction of confidence intervals for the parameterised profiles and the associated global quantities. The statistical approach is shown to provide a rigorous approach to the empirical testing of plasma profile invariance. (orig.)

  10. A HYBRID APPROACH FOR RURAL FEEDER DESIGN

    Directory of Open Access Journals (Sweden)

    DAMANJEET KAUR

    2012-08-01

    Full Text Available In this paper, a population based approach for conductor size selection in rural radial distribution system is presented. The proposed hybrid approach implies a particle swarm optimization (PSO approach in combination with mutant property of differential evolution (DE for conductor size selection in radial distribution system. The conductor size for each feeder segment is selected such that the total cost of capital investment and capitalized cost of energy losses is minimized while constraints of voltage at each node and current carrying capacity of conductor is within the limits. The applicability and effectiveness of the proposed method is demonstrated with the help of 32-node test system.

  11. Shell Model in a First Principles Approach

    International Nuclear Information System (INIS)

    We develop and apply an ab-initio approach to nuclear structure. Starting with the NN interaction, that fits two-body scattering and bound state data, and adding a theoretical NNN potential, we evaluate nuclear properties in a no-core approach. For presently feasible no-core model spaces, we evaluate an effective Hamiltonian in a cluster approach which is guaranteed to provide exact answers for sufficiently large model spaces and/or sufficiently large clusters. A number of recent applications are surveyed including an initial application to exotic multiquark systems

  12. Cavity approach to the random solid state.

    Science.gov (United States)

    Mao, Xiaoming; Goldbart, Paul M; Mézard, Marc; Weigt, Martin

    2005-09-30

    The cavity approach is used to address the physical properties of random solids in equilibrium. Particular attention is paid to the fraction of localized particles and the distribution of localization lengths characterizing their thermal motion. This approach is of relevance to a wide class of random solids, including rubbery media (formed via the vulcanization of polymer fluids) and chemical gels (formed by the random covalent bonding of fluids of atoms or small molecules). The cavity approach confirms results that have been obtained previously via replica mean-field theory, doing so in a way that sheds new light on their physical origin. PMID:16241698

  13. Cavity Approach to the Random Solid State

    CERN Document Server

    Mao, X; Mézard, M; Weigt, M; Mao, Xiaoming; Goldbart, Paul M.; Mezard, Marc; Weigt, Martin

    2005-01-01

    The cavity approach is used to address the physical properties of random solids in equilibrium. Particular attention is paid to the fraction of localized particles and the distribution of localization lengths characterizing their thermal motion. This approach is of relevance to a wide class of random solids, including rubbery media (formed via the vulcanization of polymer fluids) and chemical gels (formed by the random covalent bonding of fluids of atoms or small molecules). The cavity approach confirms results that have been obtained previously via replica mean-field theory, doing so in a way that sheds new light on their physical origin.

  14. Non-Blocking Approach in Concurrency Control

    Directory of Open Access Journals (Sweden)

    Minakshi Sangwan

    2014-06-01

    Full Text Available Majority of the research in database management system on conventional techniques requires additional efforts for deadlock detection and elimination. A deadlock occurs when a transaction waits for locks held by another transaction, which in turn, is waiting (directly or indirectly for locks held by the first transaction. In this paper we have proposed a method for non blocking approach in concurrency control. The proposed approach is a distributed approach for construction of data access graphs at data sites, within a distributed static locking environment.

  15. Design of Quiet Rotorcraft Approach Trajectories

    Science.gov (United States)

    Padula, Sharon L.; Burley, Casey L.; Boyd, D. Douglas, Jr.; Marcolini, Michael A.

    2009-01-01

    A optimization procedure for identifying quiet rotorcraft approach trajectories is proposed and demonstrated. The procedure employs a multi-objective genetic algorithm in order to reduce noise and create approach paths that will be acceptable to pilots and passengers. The concept is demonstrated by application to two different helicopters. The optimized paths are compared with one another and to a standard 6-deg approach path. The two demonstration cases validate the optimization procedure but highlight the need for improved noise prediction techniques and for additional rotorcraft acoustic data sets.

  16. An Efficient Approach to Recognize Fingerprints

    Directory of Open Access Journals (Sweden)

    Muhammad Sheikh Sadi

    2012-10-01

    Full Text Available Fingerprint analysis is typically based on the position and pattern of detected singular points in the fingerprint images. These singular points (cores and deltas represent the characteristics of local ridge patterns, determine the topological structure (i.e., fingerprint type and largely influence the orientation field. A core-delta relation is used as a global constraint for the final selection of singular points. This paper proposed an approach for singular points detection and then recognizes fingerprints based on singular points position and their relative distances. Experimental results show that the approach is efficient and robust, giving better results than existing dominant approaches.

  17. The Laplace-Jaynes approach to induction

    CERN Document Server

    Mana, P G L P; Maansson, A

    2007-01-01

    An approach to induction is presented, based on the idea of analysing the context of a given problem into `circumstances'. This approach, fully Bayesian in form and meaning, provides a complement or in some cases an alternative to that based on de Finetti's representation theorem and on the notion of infinite exchangeability. In particular, it gives an alternative interpretation of those formulae that apparently involve `unknown probabilities' or `propensities'. Various advantages and applications of the presented approach are discussed, especially in comparison to that based on exchangeability. Generalisations are also discussed.

  18. Understanding microelectronics a top-down approach

    CERN Document Server

    Maloberti, Franco

    2011-01-01

    The microelectronics evolution has given rise to many modern benefits but has also changed design methods and attitudes to learning. Technology advancements shifted focus from simple circuits to complex systems with major attention to high-level descriptions. The design methods moved from a bottom-up to a top-down approach. For today's students, the most beneficial approach to learning is this top-down method that demonstrates a global view of electronics before going into specifics. Franco Maloberti uses this approach to explain the fundamentals of electronics, such as processing functions,

  19. Introducing ANOVA and ANCOVA a GLM approach

    CERN Document Server

    Rutherford, Andrew

    2000-01-01

    Traditional approaches to ANOVA and ANCOVA are now being replaced by a General Linear Modeling (GLM) approach. This book begins with a brief history of the separate development of ANOVA and regression analyses and demonstrates how both analysis forms are subsumed by the General Linear Model. A simple single independent factor ANOVA is analysed first in conventional terms and then again in GLM terms to illustrate the two approaches. The text then goes on to cover the main designs, both independent and related ANOVA and ANCOVA, single and multi-factor designs. The conventional statistical assumptions underlying ANOVA and ANCOVA are detailed and given expression in GLM terms. Alternatives to traditional ANCO

  20. Multiscale modeling in solid mechanics computational approaches

    CERN Document Server

    Galvanetto, Ugo

    2009-01-01

    This unique volume presents the state of the art in the field of multiscale modeling in solid mechanics, with particular emphasis on computational approaches. For the first time, contributions from both leading experts in the field and younger promising researchers are combined to give a comprehensive description of the recently proposed techniques and the engineering problems tackled using these techniques. The book begins with a detailed introduction to the theories on which different multiscale approaches are based, with regards to linear Homogenisation as well as various nonlinear approach

  1. Deferred correction approach on generic transport equation

    International Nuclear Information System (INIS)

    In this study, a two dimensional Steady Convection-Diffusion was solved, using Deferred correction approach, and results were compared with standard spatial discretization schemes. Numerical investigations were carried out based on the velocity and flow direction, for various diffusivity coefficients covering a range from diffusive to convective flows. The results show that the Deferred Ted Correction Approach gives more accurate and stable results in relation to UDS and CDs discretization of convective terms. Deferred Correction Approach caters for the wiggles for convective flows in case of central difference discretization of the equation and also caters for the dissipative error generated by the first order upwind discretization of convective fluxes. (author)

  2. A Learning Approach to Shallow Parsing

    CERN Document Server

    Muñoz, M; Roth, D R; Zimak, D; Mu\\~noz, Marcia; Punyakanok, Vasin; Roth, Dan; Zimak, Dav

    2000-01-01

    A SNoW based learning approach to shallow parsing tasks is presented and studied experimentally. The approach learns to identify syntactic patterns by combining simple predictors to produce a coherent inference. Two instantiations of this approach are studied and experimental results for Noun-Phrases (NP) and Subject-Verb (SV) phrases that compare favorably with the best published results are presented. In doing that, we compare two ways of modeling the problem of learning to recognize patterns and suggest that shallow parsing patterns are better learned using open/close predictors than using inside/outside predictors.

  3. Observable algebras in the S matrix approach

    International Nuclear Information System (INIS)

    Made is an attempt to construct in the framework of the S matrix approach sets of algebras observed in the presence of an interacting neutral scalar field. The feasibility of the axioms in the Haag-Arak algebraic approach is verified. The quantum system description is in terms of asymptotic concepts. For the given local sets of algebras observed, a correspondence is fulfilled of all the axioms of the Haag-Arak algebraic approach to the forms of duality, causality, isomorphism and relativistic covariance of the S matrix

  4. Approaches of Buried Object Detection Technology

    Directory of Open Access Journals (Sweden)

    Nagashree R N

    2014-03-01

    Full Text Available This paper describes the different art of buried object detection technology and algorithms. This detection of buried object finds application in many areas, importantly in the Landmine detection which is of growing concern due to the danger of buried landmines to people’s lives, economic growth and development. This paper describes and analyzes different technology available. The approaches discussed are Electrical Impedance Tomography, X-ray backscatter, Infrared Systems, Acoustics/seismic systems; Neutron based Method and finally Ground-Penetrating Radar with two commonly available approaches: Least squares and SVD approach. Finally, the paper concludes highlighting the need to improve the way this information is processed and compared.

  5. The rehabilitative approach in rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    N. Pappone

    2011-09-01

    Full Text Available The rehabilitative approach for the patient with rheumatoid arthritis should be early, global and complementary to an early pharmacological therapy, in the context of a multidisciplinary approach, that should include physicians with different specialties and other health professionals. Evaluation scales assessing disability and quality of life are necessary for the rehabilitative approach. These can be classified in 2 groups: specific tools and generic tools, each evaluating different components of the health status. After the evaluation and the definition of the aims of the rehabilitation, a rehabilitative project, potentially including physical therapies, therapeutic exercises, occupational therapy and orthosis should be defined.

  6. Statistical inference an integrated Bayesianlikelihood approach

    CERN Document Server

    Aitkin, Murray

    2010-01-01

    Filling a gap in current Bayesian theory, Statistical Inference: An Integrated Bayesian/Likelihood Approach presents a unified Bayesian treatment of parameter inference and model comparisons that can be used with simple diffuse prior specifications. This novel approach provides new solutions to difficult model comparison problems and offers direct Bayesian counterparts of frequentist t-tests and other standard statistical methods for hypothesis testing.After an overview of the competing theories of statistical inference, the book introduces the Bayes/likelihood approach used throughout. It pre

  7. Sample Size Estimation for Non-Inferiority Trials: Frequentist Approach versus Decision Theory Approach

    Science.gov (United States)

    Bouman, A. C.; ten Cate-Hoek, A. J.; Ramaekers, B. L. T.; Joore, M. A.

    2015-01-01

    Background Non-inferiority trials are performed when the main therapeutic effect of the new therapy is expected to be not unacceptably worse than that of the standard therapy, and the new therapy is expected to have advantages over the standard therapy in costs or other (health) consequences. These advantages however are not included in the classic frequentist approach of sample size calculation for non-inferiority trials. In contrast, the decision theory approach of sample size calculation does include these factors. The objective of this study is to compare the conceptual and practical aspects of the frequentist approach and decision theory approach of sample size calculation for non-inferiority trials, thereby demonstrating that the decision theory approach is more appropriate for sample size calculation of non-inferiority trials. Methods The frequentist approach and decision theory approach of sample size calculation for non-inferiority trials are compared and applied to a case of a non-inferiority trial on individually tailored duration of elastic compression stocking therapy compared to two years elastic compression stocking therapy for the prevention of post thrombotic syndrome after deep vein thrombosis. Results The two approaches differ substantially in conceptual background, analytical approach, and input requirements. The sample size calculated according to the frequentist approach yielded 788 patients, using a power of 80% and a one-sided significance level of 5%. The decision theory approach indicated that the optimal sample size was 500 patients, with a net value of €92 million. Conclusions This study demonstrates and explains the differences between the classic frequentist approach and the decision theory approach of sample size calculation for non-inferiority trials. We argue that the decision theory approach of sample size estimation is most suitable for sample size calculation of non-inferiority trials. PMID:26076354

  8. New approach needed for more BME leadership.

    Science.gov (United States)

    2015-06-10

    The NHS needs to rethink its approach to tackling race equality if it wants to see more leaders from black and minority ethnic (BME) backgrounds, according to a clinical commissioning group (CCG) director. PMID:26058616

  9. Extended frontobasal approach to the skull base.

    Directory of Open Access Journals (Sweden)

    Banerji D

    2001-07-01

    Full Text Available The extended frontobasal approach provides an adequate midline exposure from the anterior cranial fossa to the sphenoclival region. Between November 1991 and August 1999, 13 patients with extensive anterior and anterolateral skull base tumours extending to supra and parasellar regions, cavernous sinus and sphenoclival regions were operated upon using this approach alone (7 patients or in combination with subtemporal -infratemporal (4 patients or transfacial (2 patients approaches. Gross total excision was performed in 8 patients while in 4 patients with malignant tumours and in a patient with extensive skull base fungal granuloma, only partial excision was possible. Basal repair was performed using pedicled pericranium, temporalis muscle or fascia lata. The complications included increase in the cranial nerve paresis, endophthalmitis, facial oedema, CSF leak, frontal haematoma and internal carotid artery injury. This study reviews the operative technique, the indications and the complications of extended frontobasal approach.

  10. A biomimetic approach to the manzamine alkaloids

    OpenAIRE

    Baldwin, JE; Claridge, TDW; Culshaw, AJ; Heupel, FA; Smrckova, S; Whitehead, RC

    1996-01-01

    Results from model studies of a synthetic approach to the manzamine alkaloids based on a biogenetic theory are reported together with the synthesis of a plausible biogenetic precursor to these alkaloids.

  11. A Colloquial Approach: An Active Learning Technique.

    Science.gov (United States)

    Arce, Pedro

    1994-01-01

    Addresses the problem of the effectiveness of teaching methodologies on fundamental engineering courses such as transport phenomena. Recommends the colloquial approach, an active learning strategy, to increase student involvement in the learning process. (ZWH)

  12. Renormalization Group Approach to Generalized Cosmological models

    OpenAIRE

    Ibanez, J.; Jhingan, S.

    2007-01-01

    We revisit here the problem of generalized cosmology using renormalization group approach. A complete analysis of these cosmologies, where specific models appear as asymptotic fixed-points, is given here along with their linearized stability analysis.

  13. Optimal taxation policy maximum-entropy approach

    OpenAIRE

    Jana P.; Mazumder S.K.; Das N.C.

    2003-01-01

    The object of this paper is firstly to present entropic measure of income inequality and secondly to develop maximum entropy approaches for the optimal reduction of income inequality through taxation. .

  14. A SYSTEMS BIOLOGY APPROACH TO DEVELOPMENTAL TOXICOLOGY

    Science.gov (United States)

    Abstract Recent advances in developmental biology have yielded detailed models of gene regulatory networks (GRNs) involved in cell specification and other processes in embryonic differentiation. Such networks form the bedrock on which a systems biology approach to developme...

  15. How to Approach a Traffic Light.

    Science.gov (United States)

    Katz, J. I.

    1990-01-01

    The problem of determining the most energy-efficient strategy to use in approaching a traffic light that is sighted at an unknown phase in its cycle is discussed. Included are calculations, results, and conclusions. (KR)

  16. Triton photodisintegration in three-dimensional approach

    CERN Document Server

    Shalchi, M A; 10.1140/epja/i2012-12006-9

    2012-01-01

    Two- and three- particles photodisintegration of the triton is investigated in a three-dimensional (3D) Faddeev approach. For this purpose the Jacobi momentum vectors for three particles system and spin-isospin quantum numbers of the individual nucleons are considered. Based on this picture the three-nucleon Faddeev integral equations with the two-nucleon interaction are formulated without employing the partial wave decomposition. The single nucleon current as well as $\\pi-$ and $\\rho-$ like exchange currents are used in an appropriate form to be employed in 3D approach. The exchange currents are derived from AV18 NN force. The two-body t-matrix, Deuteron and Triton wave functions are calculated in the 3D approach by using AV18 potential. Benchmarks are presented to compare the total cross section for the two- and three- particles photodisintegration in the range of $E_{\\gamma}<30 MeV$. The 3D Faddeev approach shows promising results.

  17. Approaches for Enhancing Reliability of Software Product

    Directory of Open Access Journals (Sweden)

    Priyanka #1, Trilok Gabba

    2013-07-01

    Full Text Available In modern world, we are highly dependent upon computer for most of our works. As we know, all computers are controlled by software. So, to operate a computer in a proper manner, software reliability is very necessary.Software Reliability is the probability of failure-free software operation for a specified period of time in a specified environment. The high complexity of software is the major contributing factor of Software reliability problems. Various approaches can be used to improve the reliability of software, however, it is hard to balance development time and budget with software reliability. For good reliability, two approaches have to be used, namely, reactive and proactive approach.This paper provides an overview of Software reliability, hardware reliability, reactive and proactive approaches.

  18. Nanotechnology based approaches in cancer therapeutics

    Science.gov (United States)

    Kumer Biswas, Amit; Reazul Islam, Md; Sadek Choudhury, Zahid; Mostafa, Asif; Fahim Kadir, Mohammad

    2014-12-01

    The current decades are marked not by the development of new molecules for the cure of various diseases but rather the development of new delivery methods for optimum treatment outcome. Nanomedicine is perhaps playing the biggest role in this concern. Nanomedicine offers numerous advantages over conventional drug delivery approaches and is particularly the hot topic in anticancer research. Nanoparticles (NPs) have many unique criteria that enable them to be incorporated in anticancer therapy. This topical review aims to look at the properties and various forms of NPs and their use in anticancer treatment, recent development of the process of identifying new delivery approaches as well as progress in clinical trials with these newer approaches. Although the outcome of cancer therapy can be increased using nanomedicine there are still many disadvantages of using this approach. We aim to discuss all these issues in this review.

  19. Everyday Life Sensing by Living Lab Approach

    Directory of Open Access Journals (Sweden)

    Tingan Tang

    2014-06-01

    Full Text Available Effective, agile and trusted eServcies Co-creation needs to align the formalized business procedures with the need for innovating business genuinely on the spot, or ad-hoc, namely understanding the real needs of users. An emerging innovation approach called "Living Lab" is such a 'in-vivo' and 'in-situ' approach, which emphasizes understanding users' needs in their real life contexts. Living Lab is a combination of user-centric and context-centric innovation paradigm. In this paper, we present a study of everyday lives of Chinese University students by mobile sensing based Living Lab approach. Finally, we discuss the implications of Living Lab approach and our future work. 

  20. Adolescent Suicide and Families: An Ecological Approach.

    Science.gov (United States)

    Henry, Carolyn S.; And Others

    1993-01-01

    Reviews previous theoretical approaches to understanding adolescent suicide (Durkheim's sociological theory of suicide, social learning theory, psychological theory, and family systems theory), and proposes utilization of human ecological theory. Examines factors associated with adolescent suicide at organism (individual), microsystem, mesosystem,…

  1. A "Bioethics" Approach to Teaching Health Law.

    Science.gov (United States)

    Capron, Alexander Morgan

    1988-01-01

    The reasons for offering a course in bioethics to law students and some approaches to take in addressing controversial issues are examined. The use of hypothetical vs. real cases, emphasis on clinical problems, and overall course objectives are discussed. (MSE)

  2. An Enhanced Approach for Human Computer Interface

    OpenAIRE

    Vikas Chahar

    2012-01-01

    In this paper here will discuss biometric approach [1] thatare used to create such kind of interface between humanbeing and computer that are more reliable, fast, efficient,robust and produce usable and safe system as well asfunctional system.

  3. Meson wave function from holographic approaches

    CERN Document Server

    Vega, Alfredo; Branz, Tanja; Gutsche, Thomas; Lyubovitskij, Valery E

    2010-01-01

    We discuss the light-front wave function for the valence quark state of mesons using the AdS/CFT correspondence. We consider two kinds of wave functions obtained in different holographic Soft-Wall approaches

  4. Design margin approach in LMFBR nuclear safety

    International Nuclear Information System (INIS)

    A new approach recommended for the treatment of core disruptive accidents in LMFBR safety is outlined. In place of the traditional approach in which an extreme assumed core disruption would be treated as a design basis accident for the plant containment, an approach which emphasizes prevention of such events to a confirmable low probability coupled with a margin of protection for unknowns is outlined. In addition, it is shown that the margin of protection may be provided by designing for characterized damage loadings. Recommendations are also made for standardization of these margins through national code committee action. The Clinch River Breeder Reactor is used as an example of the application of such an approach. 15 references. (U.S.)

  5. Structured synthesis of MEMS using evolutionary approaches

    DEFF Research Database (Denmark)

    Fan, Zhun; Wang, Jiachuan

    2008-01-01

    In this paper, we discuss the hierarchy that is involved in a typical MEMS design and how evolutionary approaches can be used to automate the hierarchical synthesis process for MEMS. The paper first introduces the flow of a structured MEMS design process and emphasizes that system-level lumped-parameter model synthesis is the first step of the MEMS synthesis process. At the system level, an approach combining bond graphs and genetic programming can lead to satisfactory design candidates as system-level models that meet the predefined behavioral specifications for designers to trade off. Then at the physical layout synthesis level, the selection of geometric parameters for component devices and other design variables is formulated as a constrained optimization problem and addressed using a constrained genetic algorithm approach. A multiple-resonator microsystem design is used to illustrate the integrated design automation idea using these evolutionary approaches.

  6. Recent approaches in studying leadership in organizations

    Directory of Open Access Journals (Sweden)

    Moji? Dušan

    2002-01-01

    Full Text Available Most influential recent approaches in studying organizational leadership were discussed in this article. Special attention is given to theories of transactional/transformational and charismatic leadership, having in mind their importance and wide presence in contemporary study of leadership in organizations. Other recent approaches such as visionary leadership, empowerment, team leadership etc. were also presented. Finally, an interesting view that leadership is sometimes irrelevant is discussed through an analysis of main standing points of theory about substitutes for leadership.

  7. A Combinatorial Enumeration Approach for Measuring Anonymity

    OpenAIRE

    Grégoire, Jean-Charles; Hamel, Angèle M.

    2009-01-01

    A recent paper of Edman et al. has taken a combinatorial approach to measuring the anonymity of a threshold mix anonymous communications system. Their paper looks at ways of matching individual messages sent to individual messages received, irrespective of user, and determines a measure of the anonymity provided by the system. Here we extend this approach to include in the calculation information about how many messages were sent or received by a user and we define a new met...

  8. Approach to skin ulcers in older patients.

    OpenAIRE

    Frank C

    2004-01-01

    OBJECTIVE: To provide family physicians with an approach to managing skin ulcers in older patients. SOURCES OF INFORMATION: Clinical practice guidelines and best practice guidelines were summarized to describe an evidence-based approach. MAIN MESSAGE; Preventing ulcers is important in frail older patients. Using guidelines can help prevent ulcers in institutions. Clarifying the cause and contributing factors is the first step in management. Pressure and venous ulcers are common in elderly peo...

  9. Boundary conditions: The path integral approach

    International Nuclear Information System (INIS)

    The path integral approach to quantum mechanics requires a substantial generalisation to describe the dynamics of systems confined to bounded domains. Nonlocal boundary conditions can be introduced in Feynman's approach by means of boundary amplitude distributions and complex phases to describe the quantum dynamics in terms of the classical trajectories. The different prescriptions involve only trajectories reaching the boundary and correspond to different choices of boundary conditions of selfadjoint extensions of the Hamiltonian. One dimensional particle dynamics is analysed in detail

  10. A Model-driven Measurement Approach

    OpenAIRE

    Monperrus, Martin; Jézéquel, Jean-Marc; Champeau, Joël; Hoeltzener, Brigitte

    2008-01-01

    Companies using domain specific languages in a model-driven development process need to measure their models. However, developing and maintaining a measurement software for each domain specific mod- eling language is costly. Our contribution is a model-driven measurement approach. This measurement approach is model-driven from two view- points: 1) it measures models of a model-driven development process; 2) it uses models as unique and consistent metric specifications, w.r.t a metric specific...

  11. A new Arnoldi approach for polynomial eigenproblems

    Energy Technology Data Exchange (ETDEWEB)

    Raeven, F.A.

    1996-12-31

    In this paper we introduce a new generalization of the method of Arnoldi for matrix polynomials. The new approach is compared with the approach of rewriting the polynomial problem into a linear eigenproblem and applying the standard method of Arnoldi to the linearised problem. The algorithm that can be applied directly to the polynomial eigenproblem turns out to be more efficient, both in storage and in computation.

  12. An Inverse Approach for Elucidating Dendritic Function

    OpenAIRE

    BenjaminTorben-Nielsen

    2010-01-01

    We outline an inverse approach for investigating dendritic function-structure relationships by optimizing dendritic trees for a-priori chosen computational functions. The inverse approach can be applied in two different ways. First, we can use it as a `hypothesis generator' in which we optimize dendrites for a function of general interest. The optimization yields an artificial dendrite that is subsequently compared to real neurons. This comparison potentially allows us to propose hypot...

  13. Goodness-of-fit: an economic approach

    OpenAIRE

    Cowell, Frank; Flachaire, Emmanuel; Bandyopadhyay, Sanghamitra

    2009-01-01

    Specific functional forms are often used in economic models of distributions; goodness-of-fit measures are used to assess whether a functional form is appropriate in the light of real-world data. Standard approaches use a distance criterion based on the EDF, an aggregation of differences in observed and theoretical cumulative frequencies. However, an economic approach to the problem should involve a measure of the information loss from using a badly-fitting model. This would involve an aggreg...

  14. The Minimal Geometric Deformation Approach Extended

    CERN Document Server

    Casadio, Roberto; da Rocha, Roldao

    2015-01-01

    The minimal geometric deformation approach was introduced in order to study the exterior space-time around spherically symmetric self-gravitating systems, like stars or similar astrophysical objects as well, in the Randall-Sundrum brane-world framework. A consistent extension of this approach is developed here, which contains modifications of both the time component and the radial component of a spherically symmetric metric. A modified Schwarzschild geometry is obtained as an example of its simplest application.

  15. Whole Life Cycle Cost: a new approach

    OpenAIRE

    Mévellec, Pierre; PERRY, Nicolas

    2006-01-01

    The last few years have seen significant improvements in the concepts, methods and the general approaches to calculating costs. ABC, Target Costing, Strategic Cost Management, functional analysis and costing are mobilising attention. Regardless of which of these approaches we consider, it is always from the point of view of one player whose intention is to benefit from increased knowledge of costs in order to achieve an increased control over their value-chain and profit-margins. This self-ce...

  16. A Semiparametric Approach to Dimension Reduction

    OpenAIRE

    Ma, Yanyuan; Zhu, Liping

    2012-01-01

    We provide a novel and completely different approach to dimension-reduction problems from the existing literature. We cast the dimension-reduction problem in a semiparametric estimation framework and derive estimating equations. Viewing this problem from the new angle allows us to derive a rich class of estimators, and obtain the classical dimension reduction techniques as special cases in this class. The semiparametric approach also reveals that in the inverse regression context while keepin...

  17. Approaches for Automated Software Installations in Windows

    OpenAIRE

    Ydremark, Anders

    2014-01-01

    Today Siemens Industrial Turbomachinery AB (SIT AB) installs operator-stations manually. This is a tedious and time consuming process. In this report several different approaches is researched and presented for an automated solution. Because automated installation is not a widely researched area, an exploration of different approaches and technical difficulties has  been made to use as a base when finally arriving at a recommendation for SIT AB. The result of this report shows that an approa...

  18. Future Theoretical Approaches in Nuclear Magnetic Resonance

    OpenAIRE

    Eugene Stephane Mananga

    2014-01-01

    Solving a time-dependent linear differential equation towards obtaining evolution operators is a central problem in solid-state nuclear magnetic resonance. To this end, average Hamiltonian theory and Floquet theory have been the two commonly used theoretically methods in spin dynamics of NMR. We recently introduced the Floquet-Magnus expansion approach and here, we present the methodology of potentials future theoretical approaches such as the Fer expansion, Chebyshev e...

  19. Defining electricity markets. An arbitrage cost approach

    International Nuclear Information System (INIS)

    Market definition is a crucial component of antitrust policy. There is, however, no universally accepted method of carrying out market definition. While several approaches have been presented in the literature, each has its share of drawbacks. This paper suggests that a modeling technique based upon the theory of arbitrage is well suited to answering this question. After the empirical approach is presented, it is used to calculate antitrust market definitions between electricity hubs in the American West

  20. A Bohmian approach to quantum fractals

    OpenAIRE

    Sanz, Ángel S.

    2005-01-01

    A quantum fractal is a wavefunction with a real and an imaginary part continuous everywhere, but differentiable nowhere. This lack of differentiability has been used as an argument to deny the general validity of Bohmian mechanics (and other trajectory--based approaches) in providing a complete interpretation of quantum mechanics. Here, this assertion is overcome by means of a formal extension of Bohmian mechanics based on a limiting approach. Within this novel formulation, ...

  1. A Semantic Approach for Document Clustering

    OpenAIRE

    Khaled Shaban

    2009-01-01

    Conventional document mining systems mainly use the presence or absence of keywords to mine texts. However, simple word counting and frequency distributions of term appearances do not capture the meaning behind the words, which results in limiting the ability to mine the texts. In this paper, the application of a semantic understanding-based approach to mine documents is presented. The approach is based on semantic notions to represent text, and to measure similarity between text documents. T...

  2. On Integrated Translation Approach of English Idioms

    OpenAIRE

    Linli Chen

    2010-01-01

    Idioms are the gems of a language. Translating idioms is not an easy task because not all English idioms have equivalents in Chinese idioms due to linguistic, especially cultural differences. Research indicates that there are six translation tactics in translating English idioms into Chinese: literal translation, free translation, compensatory translation, explanational translation, borrowing, integrated approach. This paper aims to propose the integrated translation approach, one indispensab...

  3. Integrated transport planning : a Queensland approach

    OpenAIRE

    Louw, J de

    2003-01-01

    Paper presented at the 22nd Annual Southern African Transport Conference 14 - 16 July 2003 "National issues affecting the movement of people and goods - strategic approaches", CSIR International Convention Centre, Pretoria, South Africa.ABSTRACT: Transport plays a vital role in maintaining quality of life and enhancing attractiveness for industry development and investment. Therefore, the transport system must be maintained effectively and enhanced through an integrated planning approach. A s...

  4. Polyhedral approach to statistical learning graphical models.

    Czech Academy of Sciences Publication Activity Database

    Studený, Milan; Hemmecke, R.; Vomlel, Ji?í; Lindner, S.

    Osaka : JST CREST, 2010. s. 1-4. [The 2nd CREST-SBM International Conference "Harmony of Groebner Bases and the Moderm Industrial Socienty". 28.06.2010-02.07.2010, Hotel Hankyu Expo Park, Osaka] Institutional research plan: CEZ:AV0Z10750506 Keywords : Bayesian network * polyhedral approach * imset Subject RIV: BA - General Mathematics http://library.utia.cas.cz/separaty/2010/MTR/studeny-polyhedral approach to statistical learning graphical models.pdf

  5. Number conserving approach in quasiparticle representation

    International Nuclear Information System (INIS)

    An exact number conserving approach is formulated in the quasiparticle representation to show the effect of the particle-number projection on the ground and the first 0+ excited states. It is applied to the two-level pairing model, which allows an exact solution and a comparison to other approaches. The present method has proved to be an advantageous alternative as compared to the BCS and to the usual methods used to restore the particle number symmetry. (author)

  6. An Approach to Persistent Scatterer Interferometry

    OpenAIRE

    Núria Devanthéry; Michele Crosetto; Oriol Monserrat; María Cuevas-González; Bruno Crippa

    2014-01-01

    This paper describes a new approach to Persistent Scatterer Interferometry (PSI) data processing and analysis, which is implemented in the PSI chain of the Geomatics (PSIG) Division of CTTC. This approach includes three main processing blocks. In the first one, a set of correctly unwrapped and temporally ordered phases are derived, which are computed on Persistent Scatterers (PSs) that cover homogeneously the area of interest. The key element of this block is given by the so-called Cousin PS...

  7. Production efficiency evaluation: analysis of approaches

    Directory of Open Access Journals (Sweden)

    Yuliya Litkovets

    2013-11-01

    Full Text Available The most common approaches to the effectiveness evaluation of both the national and in foreign practice of management are researched. The widespread in domestic management practice system of generalized and partial efficiency evaluation indicators from a position of resource-cost approach is grounded. Due to market requirements, imposed on businesses to ensure competitiveness, it is necessary to take into account the requirements of all contractors that are displayed in financial indicators.

  8. Cloud computing methods and practical approaches

    CERN Document Server

    Mahmood, Zaigham

    2013-01-01

    This book presents both state-of-the-art research developments and practical guidance on approaches, technologies and frameworks for the emerging cloud paradigm. Topics and features: presents the state of the art in cloud technologies, infrastructures, and service delivery and deployment models; discusses relevant theoretical frameworks, practical approaches and suggested methodologies; offers guidance and best practices for the development of cloud-based services and infrastructures, and examines management aspects of cloud computing; reviews consumer perspectives on mobile cloud computing an

  9. Cognitive approaches to L3 acquisition

    OpenAIRE

    Maria del Pilar Garcia Mayo

    2012-01-01

    Multilingualism has established itself as an area of systematic research in linguistic studies over the last two decades. The multilingual phenomenon can be approached from different perspectives: educational, formal linguistic, neurolinguistic, psycholinguistic and sociolinguistic, among others. This article presents an overview of cognitive (psychological and formal linguistic) approaches to third language (L3) acquisition where the assumption is that language acquisition is a complex multi...

  10. A combinatorial approach to metamaterials discovery

    International Nuclear Information System (INIS)

    We report a high throughput combinatorial approach to photonic metamaterial optimization. The new approach is based on parallel synthesis and subsequent optical characterization of large numbers of spatially addressable nanofabricated metamaterial samples (libraries) with quasi-continuous variation of design parameters under real manufacturing conditions. We illustrate this method for Fano-resonance plasmonic nanostructures, arriving at explicit recipes for high quality factors needed for switching and sensing applications

  11. Toward a socioethical approach to behavior change.

    Science.gov (United States)

    Mah, Manuel W; Meyers, Gwyneth

    2006-03-01

    Infection control professionals have traditionally relied on didacticism to promote behavior change among health care workers, but this approach yields disappointing results in a postmodern era of social fragmentation and intellectual ambiguity. We define a socioethical approach to behavior change and propose its implementation in 4 movements: from individualism to community, from rationality to rhetoric, from productivity to praxis, and from monologue to dialogue. PMID:16490610

  12. A team building approach for competency development.

    OpenAIRE

    Hlaoittinun, Onanong; Bonjour, Eric; Dulmet, Maryvonne

    2007-01-01

    An approach for multidisciplinary team building is proposed through three steps. We suppose that tasks and team members are characterized by a set of attributes (technical competencies). First, the calculation of distance measure between task and team member (profile matching) are proposed. Second, an array-based clustering algorithm is used as an effective means for providing an alternative solution in task and team-member clustering. The proposed approach generates a systematic formation of...

  13. Binary Classifier Calibration: Non-parametric approach

    OpenAIRE

    Naeini, Mahdi Pakdaman; Cooper, Gregory F.; Hauskrecht, Milos

    2014-01-01

    Accurate calibration of probabilistic predictive models learned is critical for many practical prediction and decision-making tasks. There are two main categories of methods for building calibrated classifiers. One approach is to develop methods for learning probabilistic models that are well-calibrated, ab initio. The other approach is to use some post-processing methods for transforming the output of a classifier to be well calibrated, as for example histogram binning, Pla...

  14. Isospin invariant Skyrme density functional approach

    International Nuclear Information System (INIS)

    The abinitio and configuration interaction methods when applied to heavier systems with many active particles present insurmountable computational challenges as the configuration space explodes rapidly. In nuclear physics, the method of choice to study heavier systems is the mean-field approach based on effective forces. In the present work we have formulated the isospin invariant Skyrme energy density functional approach with the inclusion of all possible neutron-proton mixed densities in the cylindrical coordinate system

  15. A Survey on Web Service Discovery Approaches

    OpenAIRE

    Mukhopadhyay, Debajyoti; Chougule, Archana

    2012-01-01

    Web services are playing an important role in e-business and e-commerce applications. As web service applications are interoperable and can work on any platform, large scale distributed systems can be developed easily using web services. Finding most suitable web service from vast collection of web services is very crucial for successful execution of applications. Traditional web service discovery approach is a keyword based search using UDDI. Various other approaches for di...

  16. Skyrmion approach to finite density and temperature

    OpenAIRE

    Park, Byung-Yoon; Vento, Vicente(Departamento de Física Teórica and IFIC, Universidad de Valencia-CSIC, 46100 Burjassot (Valencia), Spain)

    2009-01-01

    We review an approach, developed over the past few years, to describe hadronic matter at finite density and temperature, whose underlying theoretical framework is the Skyrme model, an effective low energy theory rooted in large $N_c$ QCD. In this approach matter is described by various crystal structures of skyrmions, classical topological solitons carrying baryon number, from which conventional baryons appear by quantization. Chiral and scale symmetries play a crucial role ...

  17. Banking, finance, and money: A socioeconomics approach

    OpenAIRE

    Wray, L. Randall

    2006-01-01

    This paper briefly summarizes the orthodox approach to banking, finance, and money, and then points the way toward an alternative based on socioeconomics. It argues that the alternative approach is better fitted to not only the historical record, but also sheds more light on the nature of money in modern economies. In orthodoxy, money is something that reduces transaction costs, simplifying economic life? by lubricating the market mechanism. Indeed, this is the unifying theme in virtually al...

  18. Wine Tourism: A Serious Leisure Approach

    OpenAIRE

    Carroll A. Brown; F. Ruth Smith

    2011-01-01

    Today wine tourism is emerging as an important component of rural diversification in North Carolina. Using Stebbins’ (1992) model of serious leisure as a guideline, the purpose of this study is to explore how wine tourism may be viewed as a type of serious leisure and to suggest a conceptual approach to the study of wine consumers in order to develop effective wine marketing strategies for local wineries in North Carolina. In addition, this study suggests an approach that small North Ca...

  19. On the Physicalistic Approach to Consciousness

    OpenAIRE

    Khatami, Mahmoud

    2005-01-01

    Physicalism is the basic approach of the contemporary analytic philosophy of mind to consciousness. The overall aim of this paper is to revise the crucial aspect ofphysicalistic approach to consciousness which is crystallized in the explanatory gap between the phenomenal and the causal characterization: nothing about the possible neural realization and causal role of consciousness is revealed in its phenomenal structure, and nothing about the phenomenal properties is indicated in the neura...

  20. Towards an approach to represent safety patterns

    OpenAIRE

    Antonino, Pablo; Keuler, Thorsten; Nakagawa, Elisa Yumi

    2012-01-01

    Safety-critical systems are complex entities, which, due to severe regulations, demand continuous development of approaches for supporting their construction. To keep safety-critical systems free of failures, it is fundamental to identify potential failure modes and their causes, and to eliminate them. One major approach to solving failure modes is the application of safety patterns at the architectural level of such systems. However, this is not trivial, since safety patterns have not been r...

  1. Analysis and Evaluation of Organizational Change Approaches

    OpenAIRE

    Yuan Liu

    2009-01-01

    Organizational change is the trend for the further development and which been explained is the enduring quest of scholars in many disciplines. Prescriptive approach and emergent approach are two main types of models for organizational change. The ‘Seven S Framework’ from Peters and his colleague to show the interrelationships between different aspects of corporate strategy. Mintzberg developed his rational concept of an organisation as composed of five segments and uses his model flexibly...

  2. Portfolio choice beyond the traditional approach

    OpenAIRE

    Penaranda, Francisco

    2007-01-01

    This paper surveys asset allocation methods that extend the traditional approach. An important feature of the traditional approach is that measures the risk and return tradeoff in terms of mean and variance of final wealth. However, there are also other important features that are not always made explicit in terms of investor’s wealth, information, and horizon: The investor makes a single portfolio choice based only on the mean and variance of her final financial wealth and she knows the re...

  3. 04. Experiential Integrative Approaches to Heart Health

    OpenAIRE

    Haramati, Adi; Eisenberg, David; Devries, Stephen

    2013-01-01

    Focus Areas: Integrative Approaches to Care, Experiential Workshop This session will highlight two of the most important, yet frequently overlooked, determinants of heart health: mind-body interactions and nutrition. These areas will be explored through didactic and experiential learning. The session will begin with a short presentation by Dr Adi Haramati on the physiology of stress and the scientific basis for mind-body approaches to de-stress, followed by an experiential autogenic exercise ...

  4. Microsurgical Anatomy for Lateral Approaches to the Foramen Magnum with Special Reference to Transcondylar Fossa (Supracondylar Transjugular Tubercle) Approach

    OpenAIRE

    Matsushima, Toshio; Natori, Yoshihiro; Katsuta, Toshiro; Ikezaki, Kiyonobu; Fukui, Masashi; Rhoton, Albert L.

    1998-01-01

    Microsurgical anatomy for lateral approaches to the foramen magnum, especially for transcondylar fossa (supracondylar transjugular tubercle) approach, was studied using cadavers. The transcondylar fossa approach is an approach in which extradural removal of the posterior portion of the jugular tubercle through the condylar fossa is added to the far lateral approach. Some differences between this approach and the transcondylar approach are demonstrated. The atlanto-occipital joint and the jugu...

  5. Portfolio optimization using median-variance approach

    Science.gov (United States)

    Wan Mohd, Wan Rosanisah; Mohamad, Daud; Mohamed, Zulkifli

    2013-04-01

    Optimization models have been applied in many decision-making problems particularly in portfolio selection. Since the introduction of Markowitz's theory of portfolio selection, various approaches based on mathematical programming have been introduced such as mean-variance, mean-absolute deviation, mean-variance-skewness and conditional value-at-risk (CVaR) mainly to maximize return and minimize risk. However most of the approaches assume that the distribution of data is normal and this is not generally true. As an alternative, in this paper, we employ the median-variance approach to improve the portfolio optimization. This approach has successfully catered both types of normal and non-normal distribution of data. With this actual representation, we analyze and compare the rate of return and risk between the mean-variance and the median-variance based portfolio which consist of 30 stocks from Bursa Malaysia. The results in this study show that the median-variance approach is capable to produce a lower risk for each return earning as compared to the mean-variance approach.

  6. Resource Distribution Approaches in Spectrum Sharing Systems

    Directory of Open Access Journals (Sweden)

    Friedrich K. Jondral

    2008-05-01

    Full Text Available It is increasingly difficult to satisfy growing demands for spectrum with the conventional policy of fixed spectrum allocation. To overcome this problem, flexible/dynamic spectrum sharing methods that can significantly improve spectrum utilization of the spectrum have gained increasing interest recently. This paper presents two dynamic spectrum sharing approaches, a centralized and a decentralized one. The centralized approach is based on hierarchical trading. Each level of hierarchy is composed of “markets” that are associated with a certain spatial area and trading occurrence frequency, whereas area size and trading occurrence frequency depend on the hierarchy level. The decentralized approach is based on game-theory. There, it is assumed that the operators are averse to unequal payoffs and act unselfishly, enabling a stable and sustainable community. Numerical results show that, in the observed scenario, both proposals outperform the reference case of fixed resource allocation significantly in terms of utilized bandwidth. Whereas, negotiation costs for spectrum brokerage appear in the centralized approach, nonnegligible amounts of spectrum are lost in the decentralized approach due to collisions. Thus, a hybrid of centralized and decentralized approach that exploits the benefits of both is also considered.

  7. Improved Statistical Speech Segmentation Using Connectionist Approach

    Directory of Open Access Journals (Sweden)

    M. S. Salam

    2009-01-01

    Full Text Available Problem statement: Speech segmentation is an important part for speech recognition, synthesizing and coding. Statistical based approach detects segmentation points via computing spectral distortion of the signal without prior knowledge of the acoustic information proved to be able to give good match, less omission but lot of insertion. These insertion points dropped segmentation accuracy. Approach: This study proposed a fusion method between statistical and connectionist approaches namely the divergence algorithm and Multi Layer Perceptron (MLP with adaptive learning for segmentation of Malay connected digit with the aim to improve statistical approach via detection of insertion points. The neural network was optimized via trial and error in finding suitable parameters and speech time normalization methods. The best neural network classifier was then fusion with divergence algorithm to make segmentation. Results: The results of the experiments showed that the best neural network classifier used learning rate of value 1.0 and momentum rate of value 0.9 with data normalization based on zero-padded. The segmentation using fusion of statistical and connectionist was able to reduce insertion points up to 10.4% while maintaining match points above 99% and omission point below 0.7% within time tolerance of 0.09 second. Conclusion: The result of segmentation using the proposed fusion method indicated potential use of connectionist approach in improving continuous segmentation by statistical approach.

  8. Introduction to Approaches in Music Therapy. Second Edition

    Science.gov (United States)

    Darrow, Alice Ann, Ed.

    2008-01-01

    The second edition of "Introduction to Approaches in Music Therapy" includes a new introductory chapter that addresses historical perspectives on the approaches, a rationale for the categorization of approaches, and discussion on professional issues related to the use of these approaches. Each of the chapters addressing approaches includes updated…

  9. A holistic approach to bit preservation

    DEFF Research Database (Denmark)

    Zierau, Eld

    2012-01-01

    Purpose: The purpose of this paper is to point out the importance of taking a holistic approach to bit preservation when setting out to find an optimal bit preservation solution for specific digital materials. In the last decade there has been an increasing awareness that bit preservation, which is to keep bits intact and readable, is far more complex than first anticipated, even in this narrow definition. This paper takes a more holistic approach to bit preservation, and looks at how an optimal bit preservation strategy can be found, when requirements like confidentiality, availability and costs are taken into account. Design/methodology/approach: The paper describes the various findings from previous research which have led to the holistic approach to bit preservation. This paper also includes an introduction to digital preservation with a focus on the role of bit preservation, which sets the scene for why bit preservation deserves attention in a holistic approach. Findings: The paper presents different means to find an optimal bit preservation strategy. This consists of a model to delimit bit preservation activities, and will briefly discuss how specific material can require different bit preservation strategies as well as pointing to how such strategies can be evaluated. Research limitations/implications The operational results described here are still missing work to be fully operational. However, the holistic approach is in itself an important result. Furthermore, in spite of the shortcomings, the results can assist in analysis and evaluation of bit preservation strategies. Originality/value This paper is an extract of the findings presented in the doctoral thesis “A holistic approach to bit preservation”. The findings are relevant for any organisation that is required to do bit preservation of its digital material.

  10. Sustainable Development: Does the Capability Approach have Anything to Offer? : Outlining a Legitimate Freedom Approach

    DEFF Research Database (Denmark)

    Crabtree, Andrew

    2013-01-01

    Although the sustainability of development is one of the most important problems facing the world, it has received little attention from the capability approach. This article asks whether the capability approach has anything to offer the debate that has continued for over a quarter of a century. Answering positively, the article outlines a legitimate freedom approach as a fruitful way forward. The approach draws on Thomas Scanlon's contractualist ethics, suggesting ways to understand the limits to freedoms, the non-identity problem and environmental ethics.

  11. Approach to uncertainty in risk analysis

    International Nuclear Information System (INIS)

    In the Fall of 1985 EPA's Office of Radiation Programs (ORP) initiated a project to develop a formal approach to dealing with uncertainties encountered when estimating and evaluating risks to human health and the environment. Based on a literature review of modeling uncertainty, interviews with ORP technical and management staff, and input from experts on uncertainty analysis, a comprehensive approach was developed. This approach recognizes by design the constraints on budget, time, manpower, expertise, and availability of information often encountered in ''real world'' modeling. It is based on the observation that in practice risk modeling is usually done to support a decision process. As such, the approach focuses on how to frame a given risk modeling problem, how to use that framing to select an appropriate mixture of uncertainty analyses techniques, and how to integrate the techniques into an uncertainty assessment that effectively communicates important information and insight to decision-makers. The approach is presented in this report. Practical guidance on characterizing and analyzing uncertainties about model form and quantities and on effectively communicating uncertainty analysis results is included. Examples from actual applications are presented

  12. Novel and Flexible Approach to Trust Negotiations

    Directory of Open Access Journals (Sweden)

    G. Ramachandran

    2013-10-01

    Full Text Available Within the progress of society today Current real applications require flexible approaches to trust negotiations, especially in light of the widespread use of mobile devices. Moreover the ubiquitous nature of online peer-to-peer systems, and the increasing number of moving objects involved in online transactions, negotiators must be allowed to switch roles to guarantee dependability, availability of resources and peers. Existing method mostly focused on the assurance of privacy and confidentiality with the goal of guaranteeing that no actual information about a negotiator’s properties is disclosed. In this paper, we introduce a novel approach to trust negotiations that offers a general solution to those issues by developing major extensions to previous approaches by presenting a multi session dependable approach to trust negotiations. This proposed framework supports voluntary and unpredicted interruptions, enabling the negotiating parties to complete the negotiation despite temporary unavailability of resources. In our approach the protocols address issues related to validity, temporary loss of data, and extended unavailability negotiators. For increasing robustness and efficiency we showed how our negotiation protocol can withstand in most significant attacks.

  13. Streamflow disaggregation: a nonlinear deterministic approach

    Directory of Open Access Journals (Sweden)

    B. Sivakumar

    2004-01-01

    Full Text Available This study introduces a nonlinear deterministic approach for streamflow disaggregation. According to this approach, the streamflow transformation process from one scale to another is treated as a nonlinear deterministic process, rather than a stochastic process as generally assumed. The approach follows two important steps: (1 reconstruction of the scalar (streamflow series in a multi-dimensional phase-space for representing the transformation dynamics; and (2 use of a local approximation (nearest neighbor method for disaggregation. The approach is employed for streamflow disaggregation in the Mississippi River basin, USA. Data of successively doubled resolutions between daily and 16 days (i.e. daily, 2-day, 4-day, 8-day, and 16-day are studied, and disaggregations are attempted only between successive resolutions (i.e. 2-day to daily, 4-day to 2-day, 8-day to 4-day, and 16-day to 8-day. Comparisons between the disaggregated values and the actual values reveal excellent agreements for all the cases studied, indicating the suitability of the approach for streamflow disaggregation. A further insight into the results reveals that the best results are, in general, achieved for low embedding dimensions (2 or 3 and small number of neighbors (less than 50, suggesting possible presence of nonlinear determinism in the underlying transformation process. A decrease in accuracy with increasing disaggregation scale is also observed, a possible implication of the existence of a scaling regime in streamflow.

  14. A novel approach for coronoid fractures.

    Science.gov (United States)

    Shukla, Dave R; Koehler, Steven M; Guerra, Sara M; Hausman, Michael R

    2014-12-01

    The coronoid process serves as an important constraint that provides ulnohumeral joint stability. We describe a novel approach to coronoid fractures that minimizes surgical dissection, without compromising fracture visualization. We present the case of a 65-year-old woman who sustained an anteromedial facet fracture of the coronoid process. The elbow demonstrated intractable posteromedial instability and the inability to maintain reduction even up to 90 degrees. This report describes a surgical approach to the coronoid process that minimizes extensive soft tissue dissection. It is a variation of the previously described approach by Taylor and Scham, although it can achieve a similar exposure without elevation of the entirety of the flexor-pronator mass. Our approach involves a limited skin incision, followed by elevation of enough of the flexor-pronator mass such that adequate visualization of the posterior medial collateral ligament (which was repaired), anteromedial facet, and the fractured fragment of coronoid were achieved. Moreover, this approach enables the course of the ulnar nerve to remain unaltered. PMID:25289725

  15. Heat-kernel approach for scattering

    CERN Document Server

    Li, Wen-Du

    2015-01-01

    An approach for solving scattering problems, based on two quantum field theory methods, the heat kernel method and the scattering spectral method, is constructed. This approach has a special advantage: it is not only one single approach; it is indeed a set of approaches for solving scattering problems. Concretely, we build a bridge between a scattering problem and the heat kernel method, so that each method of calculating heat kernels can be converted into a method of solving a scattering problem. As applications, we construct two approaches for solving scattering problems based on two heat-kernel expansions: the Seeley-DeWitt expansion and the covariant perturbation theory. In order to apply the heat kernel method to scattering problems, we also calculate two off-diagonal heat-kernel expansions in the frames of the Seeley-DeWitt expansion and the covariant perturbation theory, respectively. Moreover, as an alternative application of the relation between heat kernels and partial-wave phase shifts presented in...

  16. Systematic Approach for Decommissioning Planning and Estimating

    Energy Technology Data Exchange (ETDEWEB)

    Dam, A. S.

    2002-02-26

    Nuclear facility decommissioning, satisfactorily completed at the lowest cost, relies on a systematic approach to the planning, estimating, and documenting the work. High quality information is needed to properly perform the planning and estimating. A systematic approach to collecting and maintaining the needed information is recommended using a knowledgebase system for information management. A systematic approach is also recommended to develop the decommissioning plan, cost estimate and schedule. A probabilistic project cost and schedule risk analysis is included as part of the planning process. The entire effort is performed by a experienced team of decommissioning planners, cost estimators, schedulers, and facility knowledgeable owner representatives. The plant data, work plans, cost and schedule are entered into a knowledgebase. This systematic approach has been used successfully for decommissioning planning and cost estimating for a commercial nuclear power plant. Elements of this approach have been used for numerous cost estimates and estimate reviews. The plan and estimate in the knowledgebase should be a living document, updated periodically, to support decommissioning fund provisioning, with the plan ready for use when the need arises.

  17. Approaches for Categorization of Reusable Software Components

    Directory of Open Access Journals (Sweden)

    Parvinder S. Sandhu

    2007-01-01

    Full Text Available Reuse repositories manager manages the reusable software components in different categories and needs to find the category of reusable software components. In this paper, we have used different pure and hybrid approaches to find the domain relevancy of the component to a particular domain. Probabilistic Latent Semantic Analysis (PLSA approach, LSA, Singular Value Decomposition (SVD technique, LSA Semi-Discrete Matrix Decomposition (SDD technique and Naive Bayes Approach purely as well as hybrid, are evaluated to determine the Domain Relevancy of software components. It exploits the fact that Feature Vector codes can be seen as documents containing terms -the identifiers present in the components- and so text modeling methods that capture co-occurrence information in low-dimensional spaces can be used. The FV code representation of clusters or domains is used to find the domain-relevancy of the software components. PLSA has provided better results than LSA retrieval techniques in terms of Precision and Recall but its time complexity is too high. SVD Transformation with Naïve Bayes scheme has outperformed all other approaches and shows better results than the existing approach (LSA being used by some open source code repositories e.g. Sourceforge. The DR-value determined is close to the manual analysis, used to be performed by the programmers/repository managers. Hence, the tool can also be utilized for the automatic categorization of software components and this kind of automation may improve the productivity and quality of software development.

  18. Transradial approach to lower extremity interventions

    Directory of Open Access Journals (Sweden)

    Ravikiran Korabathina

    2010-07-01

    Full Text Available Ravikiran Korabathina1, Sidharth S Yadav1, John T Coppola2, Cezar S Staniloae21Department of Cardiovascular Medicine, Saint Vincents Catholic Medical Center, New York, NY, USA; 2Cardiac and Vascular Institute, New York University Medical Center, New York, NY, USAAbstract: Percutaneous interventions of the coronary and peripheral vessels have historically been performed using a femoral artery approach. There has been increasing recognition of postprocedural bleeding complications and its impact on short- and long-term mortality. Because of its now recognized safety, the transradial approach has recently emerged as a preferred method compared to the transfemoral approach. The limitations associated with the distance from the puncture site to the lesion location are being addressed as new tools are developed for the endovascular treatment of peripheral arterial disease. In this review, we discuss the many facets of the transradial approach to lower extremity endovascular interventions, highlighting its safety and efficacy. Approaches to special populations including individuals with prior surgical bypass, Leriche’s syndrome, and those committed to chronic anticoagulation are also reviewed.Keywords: peripheral arterial disease, endovascular interventions, transradial interventions, aorto-iliac angioplasty

  19. Monolithic Approach to Oxide Dispersion Strengthened Aluminum Project

    National Aeronautics and Space Administration — Nassau Stern Company is investigating an approach for manufacturing oxide dispersion strengthened (ODS) aluminum in bulk rather than powder form. The approach...

  20. An Instrumentalists Approach Towards Quantum Logic

    CERN Document Server

    Hermens, Ronnie

    2011-01-01

    Within the many versions of the Copenhagen interpretation numerous hints can be found about how to reason about quantum mechanics. However, strict guidelines are often missing. The standard quantum logic is sometimes opted as providing such a guideline but, in itself, it is again puzzling due to the failure of the law of distributivity. In this paper I take an instrumentalist approach inspired by the Copenhagen interpretation towards the interpretation of propositions in a physical theory. Starting with so-called elementary propositions for a physical theory I introduce logical connectives in accordance with this approach and relate the thereby expanding set of propositions to mathematical objects within the theory in a consistent way. This is first done for classical mechanics and then for quantum mechanics. In both cases this approach leads to the development of intuitionistic logics rather than classical ones. It also follows that the obtained intuitionistic quantum logic is a proper generalization of the ...

  1. Arabic Words Stemming Approach Using Arabic Wordnet

    Directory of Open Access Journals (Sweden)

    Abdel Hamid Kreaa

    2014-08-01

    Full Text Available The big growth of the Arabic internet content in the last years has raised up the need for an effective stemming techniques for Arabic language. Arabic stemming algorithms can be ranked, according to three category, as root-based approach (ex. Khoja; stem-based approach (ex. Larkey; and statistical approach (ex. N-Garm. However, no stemming of this language is perfect: The existing stemmers have a low efficiency. In this paper, we introduce a new stemming technique for Arabic words that also solve the problem of the plural form of irregular nouns in Arabic language, which called broken plural. The proposed stem extractor provides very accurate results in comparisons with other algorithms. Consequently the search effectiveness improved.

  2. THE SOCIOLOGIC APPROACH OF FEMININE CRIMINALITY

    Directory of Open Access Journals (Sweden)

    MIRELA CRISTIANA NILA STRATONE

    2012-05-01

    Full Text Available The present study is part of a much more cognitive approach, which tries to study resocialization and the social reinsertion of women who are under freedom privation penalty. The present material contains a short historical evolution of the sociologic theories of crime, then plunging towards feminist theories, in order to approach the gender problematic concerning the delinquent woman.. The first objective is to demonstrate the necessity of a wider approach in analyzing the genesis of the crime, through the re-evaluation and reconsidering the factors with a crime risk and placing them in an equal position in the social environment. Another objective of this study is to emphasize the importance of the gender role concerning the expectations of the society from the feminine population’s side. The present study is focused on the contribution of placing the research of feminine crime research on a basis characterized by unprecedented generality, under total influencing conditions, with orientation towards gender problematic.

  3. Document Recommender Agent Based on Hybrid Approach

    Directory of Open Access Journals (Sweden)

    Khalifa

    2014-04-01

    Full Text Available As Internet continues to grow, user tends to rely heavily on search engines. However, these search engines tend to generate a huge number of search results and potentially making it difficult for users to find the most relevant sites. This has resulted in search engines losing their usefulness. These users might be academicians who are searching for relevant academic papers within their interests. The need for a system that can assist in choosing the most relevant papers among the long list of results presented by search engines becomes crucial. In this paper, we propose Document Recommender Agent, that can recommend the most relevant papers based on the academician’s interest. This recommender agent adopts a hybrid recommendation approach. In this paper we also show that recommendation based on the proposed hybrid approach is better that the content-based and the collaborative approaches.

  4. Accident prevention in a contextual approach

    DEFF Research Database (Denmark)

    Dyhrberg, Mette Bang

    2003-01-01

    Many recommendations on how to establish an accident prevention program do exist. The aim of many agencies is to promote the implementation of these recommendations in enterprises. The discussion has mainly focused on incentives either in the form of an effective enforcement of the law or as a focus on developing the insurance system to establish (economic) motivation. This paper suggests a more elaborated theoretical approach emphasising a differentiated understanding of the external and internal actors and how these relations form the actions of the actors. The theoretical components of such a contextual approach is shortly described and demonstrated in relation to a Danish case on accident prevention. It is concluded that the approach presently offers a post-ante, descriptive analytical understanding, and it is argued that it can be developed to a frame of reference for planning actions and programs on accident prevention.

  5. Phenomenological approaches of inflation and their equivalence

    Science.gov (United States)

    Boubekeur, Lotfi; Giusarma, Elena; Mena, Olga; Ramírez, Héctor

    2015-04-01

    In this work, we analyze two possible alternative and model-independent approaches to describe the inflationary period. The first one assumes a general equation of state during inflation due to Mukhanov, while the second one is based on the slow-roll hierarchy suggested by Hoffman and Turner. We find that, remarkably, the two approaches are equivalent from the observational viewpoint, as they single out the same areas in the parameter space, and agree with the inflationary attractors where successful inflation occurs. Rephrased in terms of the familiar picture of a slowly rolling, canonically normalized scalar field, the resulting inflaton excursions in these two approaches are almost identical. Furthermore, once the Galactic dust polarization data from Planck are included in the numerical fits, inflaton excursions can safely take sub-Planckian values.

  6. Cooperative learning as an approach to pedagogy.

    Science.gov (United States)

    Nolinske, T; Millis, B

    1999-01-01

    Lecture-based pedagogical approaches cannot adequately prepare students in professional and technical occupational therapy programs. Faculty members in other disciplines are turning to a well-known and well-researched teaching approach called cooperative learning, which is more carefully structured and defined than most other forms of small group learning. Cooperative learning includes several key principles: positive interdependence, individual responsibility, appropriate grouping, group maintenance, cooperative skills, and promotive (interaction) time. This article provides ideas for managing the classroom with cooperative learning activities and describes eight of them: Three-Step Interview, Roundtable, Think-Pair-Share, Structured Problem Solving, Send/Pass-a-Problem, Generic Question Stems, Double Entry Journal, and Dyadic Essay Confrontation. Each activity is applied to content embedded in professional and technical occupational therapy curricula. A cooperative learning approach to evaluating learning is also presented. PMID:9926216

  7. Neural Hypernetwork Approach for Pulmonary Embolism diagnosis

    CERN Document Server

    Rucco, Matteo; Merelli, Emanuela; Johnson, Jeffrey H; Falsetti, Lorenzo; Nitti, Cinzia; Salvi, Aldo

    2014-01-01

    This work introduces an integrative approach based on Q-analysis with machine learning. The new approach, called Neural Hypernetwork, has been applied to a case study of pulmonary embolism diagnosis. The objective of the application of neural hyper-network to pulmonary embolism (PE) is to improve diagnose for reducing the number of CT-angiography needed. Hypernetworks, based on topological simplicial complex, generalize the concept of two-relation to many-body relation. Furthermore, Hypernetworks provide a significant generalization of network theory, enabling the integration of relational structure, logic and analytic dynamics. Another important results is that Q-analysis stays close to the data, while other approaches manipulate data, projecting them into metric spaces or applying some filtering functions to highlight the intrinsic relations. A pulmonary embolism (PE) is a blockage of the main artery of the lung or one of its branches, frequently fatal. Our study uses data on 28 diagnostic features of 1,427...

  8. Management Approach for Earth Venture Instrument

    Science.gov (United States)

    Hope, Diane L.; Dutta, Sanghamitra

    2013-01-01

    The Earth Venture Instrument (EVI) element of the Earth Venture Program calls for developing instruments for participation on a NASA-arranged spaceflight mission of opportunity to conduct innovative, integrated, hypothesis or scientific question-driven approaches to pressing Earth system science issues. This paper discusses the EVI element and the management approach being used to manage both an instrument development activity as well as the host accommodations activity. In particular the focus will be on the approach being used for the first EVI (EVI-1) selected instrument, Tropospheric Emissions: Monitoring of Pollution (TEMPO), which will be hosted on a commercial GEO satellite and some of the challenges encountered to date and corresponding mitigations that are associated with the management structure for the TEMPO Mission and the architecture of EVI.

  9. A hybrid approach to protect palmprint templates.

    Science.gov (United States)

    Liu, Hailun; Sun, Dongmei; Xiong, Ke; Qiu, Zhengding

    2014-01-01

    Biometric template protection is indispensable to protect personal privacy in large-scale deployment of biometric systems. Accuracy, changeability, and security are three critical requirements for template protection algorithms. However, existing template protection algorithms cannot satisfy all these requirements well. In this paper, we propose a hybrid approach that combines random projection and fuzzy vault to improve the performances at these three points. Heterogeneous space is designed for combining random projection and fuzzy vault properly in the hybrid scheme. New chaff point generation method is also proposed to enhance the security of the heterogeneous vault. Theoretical analyses of proposed hybrid approach in terms of accuracy, changeability, and security are given in this paper. Palmprint database based experimental results well support the theoretical analyses and demonstrate the effectiveness of proposed hybrid approach. PMID:24982977

  10. Russia and Ukraine: Media Literacy Education Approaches

    Directory of Open Access Journals (Sweden)

    Alexander V. Fedorov

    2012-09-01

    Full Text Available For many decades of the Soviet period the development of media education in Russia and Ukraine has been practically coinciding. Media educational lessons (mainly on the material of cinematography and the press were of optional and focal character and depended on the enthusiasm of certain teachers. In theory and methodology the aesthetic and practical approaches predominated. In the 1960es – 1980es the most active was the Kiev group of Ukrainian film educators. Besides study groups, elective courses (aesthetic approach and film/photo/video studious, school and university amateur newspapers and magazines (practical approach media education was developing in an integrating form – within the compulsory subjects as literature, history, Russian, Ukrainian and foreign languages. The situation changed in modern times: Russia is leading in media education literacy researches, and Ukraine - in the practical media education in schools.

  11. A Semantic Approach for Document Clustering

    Directory of Open Access Journals (Sweden)

    Khaled Shaban

    2009-07-01

    Full Text Available Conventional document mining systems mainly use the presence or absence of keywords to mine texts. However, simple word counting and frequency distributions of term appearances do not capture the meaning behind the words, which results in limiting the ability to mine the texts. In this paper, the application of a semantic understanding-based approach to mine documents is presented. The approach is based on semantic notions to represent text, and to measure similarity between text documents. The representation scheme reflects existing relations between concepts and facilitates accurate similarity measurements that result in better mining performance. A document mining process, namely semantic document clustering, is investigated and tackled in various ways. The proposed representation scheme along with the proposed similarity measure were implemented as vital components of a mining system. The approach has enabled more effective document clustering than what conventional techniques would provide. The experimental work is reported, and its results are presented and analyzed.

  12. / A Hybrid Approach for Event Extraction

    Scientific Electronic Library Online (English)

    Anup, Kumar Kolya; Asif, Ekbal; Sivaji, Bandyopadhyay.

    2012-12-01

    Full Text Available [...] Abstract in english Event extraction is a popular and interesting research field in the area of Natural Language Processing (NLP). In this paper, we propose a hybrid approach for event extraction within the TimeML framework. Initially, we develop a machine learning based system based on Conditional Random Field (CRF). [...] But most of the deverbal event nouns are not correctly identified by this machine learning approach. From this observation, we came up with a hybrid approach where we introduce several strategies in conjunction with machine learning. These strategies are based on semantic role-labeling, WordNet and handcrafted rules. Evaluation results on the TempEval-2010 datasets yield the precision, recall and F-measure values of approximately 93.00%, 96.00% and 94.47%, respectively. This is approximately 12% higher F-measure in comparison with the best performing system of SemEval-2010.

  13. An integral approach to substance abuse.

    Science.gov (United States)

    Amodia, Diana S; Cano, Carol; Eliason, Michele J

    2005-12-01

    There is a pressing need in the substance abuse field for more comprehensive models of etiology and treatment that address the complex issues of addiction, including the biological, social, cultural, spiritual and developmental needs of individuals and groups. This article presents a theoretical framework for an integral approach to substance abuse that expands on the existing biopsychosocial model. One contribution of the model is an integrated approach to spirituality from a cross-cultural perspective. This integral approach examines substance abuse etiology and treatment from a four-quadrant perspective adapted from the work of Ken Wilber, and incorporates concepts from integrative medicine and transpersonal psychology/psychiatry. Implications of the model are explored. PMID:16480163

  14. A neuroanatomical approach to exploring organizational performance

    Directory of Open Access Journals (Sweden)

    Gillingwater, D.

    2009-01-01

    Full Text Available Insights gained from studying the human brain have begun to open up promising new areas of research in the behavioural and social sciences. Neuroscience-based principles have been incorporated into areas such as business management, economics and marketing, leading to the development of artificial neural networks, neuroeconomics, neuromarketing and, most recently, organizational cognitive neuroscience. Similarly, the brain has been used as a powerful metaphor for thinking about and analysing the nature of organizations. However, no existing approach to organizational analysis has taken advantage of contemporary neuroanatomical principles, thereby missing the opportunity to translate core neuroanatomical knowledge into other, non-related areas of research. In this essentially conceptual paper, we propose several ways in which neuroanatomical approaches could be used to enhance organizational theory, practice and research. We suggest that truly interdisciplinary and collaborative research between neuroanatomists and organizational analysts is likely to provide novel approaches to exploring and improving organizational performance.

  15. A System Approach to Environmental Education

    Directory of Open Access Journals (Sweden)

    Z. Kostova

    2007-09-01

    Full Text Available A system approach to environmental education (EE is developed. By making use of it the educators will be able to introduce successfully ecological principles and global environmental problems in the educational system for the development of environmental culture, consciousness and behavior. It embraces a long period of thinking, designing, experimenting and rethinking in the light of the new ideas, concerning humanity-nature relationships. The core of the system approach is represented by environmental consciousness, which is the driving force of environmentally responsible behavior. The system approach is concerned with constructing an innovative model of EE, which consists of three elements: didactical, conceptual and technological and six integrating concepts, uniting the studies of the different school subjects under the global movement for sustainable development. EE is regarded to be an essential part of the education for sustainable development (ESD.

  16. Hydrodynamic Approaches in Relativistic Heavy Ion Reactions

    CERN Document Server

    de Souza, Rafael Derradi; Kodama, Takeshi

    2015-01-01

    We review several facets of the hydrodynamic description of the relativistic heavy ion collisions, starting from the historical motivation to the present understandings of the observed collective aspects of experimental data, especially those of the most recent RHIC and LHC results. In this report, we particularly focus on the conceptual questions and the physical foundations of the validity of the hydrodynamic approach itself. We also discuss recent efforts to clarify some of the points in this direction, such as the various forms of derivations of relativistic hydrodynamics together with the limitations intrinsic to the traditional approaches, variational approaches, known analytic solutions for special cases, and several new theoretical developments. Throughout this review, we stress the role of course-graining procedure in the hydrodynamic description and discuss its relation with the physical observables through the analysis of a hydrodynamic mapping of a microscopic transport model. Several questions to...

  17. RST Approach for Efficient CARs Mining

    Directory of Open Access Journals (Sweden)

    Thabet Slimani

    2014-11-01

    Full Text Available In data mining, an association rule is a pattern that states the occurrence of two items (premises and consequences together with certain probability. A class association rule set (CARs is a subset of association rules with classes specified as their consequences. This paper focuses on class association rules mining based on the approach of Rough Set Theory (RST. In addition, this paper presents an algorithm for finest class rule set mining inspired from Apriori algorithm, where the support and confidence are computed based on the elementary set of lower approximation inspired from RST. The proposed approach has been shown very effective, where the rough set approach for class association discovery is much simpler than the classic association method

  18. Field approach in the transformation optics concept

    DEFF Research Database (Denmark)

    Novitsky, Andrey; Zhukovsky, Sergei

    2012-01-01

    An alternative, field-based formulation of transformation optics is proposed. Field transformations are expressed in the language of boundary conditions for the electromagnetic fields facilitated through the introduction of generalized potential functions. It is shown that the field-based approach is equivalent to the conventional coordinate-transformation approach but is preferable when looking for specific field distribution. A set of example devices such as invisibility cloaks, concentrators, rotators, and transformation optics lenses capable of creating light beams with predetermined field distribution (e.g., Gaussian and sinusoidal) is studied to validate the effectiveness of the field-based formulation. As for the boundary conditions for the cloaked region the absence of the normal component of the Poynting vector is justified. In the frames of the field-based approach the physical reasons behind infinite components (singularities) of the material parameters of transformation optics devices are straightforwardly revealed.

  19. Sectoral Approaches to Greenhouse Gas Mitigation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This paper explores sectoral approaches as a new set of options to enhance the effectiveness of greenhouse gas reduction policies and to engage emerging economies on a lower emission path. It surveys existing literature and recent policy trends in international climate change discussions, and provides an overview of sectoral approaches and related issues for trade-exposed, greenhouse-gas intensive industries (cement, iron and steel and aluminium). It is also based on interviews conducted by the IEA Secretariat in Australia, China, Europe, Japan, and the United States. Sectoral approaches were also discussed during workshops on technology and energy efficiency policies in industry, following the IEA's mandate under the Gleneagles Plan of Action.

  20. Physical approaches to DNA sequencing and detection

    CERN Document Server

    Zwolak, Michael

    2007-01-01

    With the continued improvement of sequencing technologies, the prospect of genome-based medicine is now at the forefront of scientific research. To realize this potential, however, we need a revolutionary sequencing method for the cost-effective and rapid interrogation of individual genomes. This capability is likely to be provided by a physical approach to probing DNA at the single nucleotide level. This is in sharp contrast to current techniques and instruments which probe, through chemical elongation, electrophoresis, and optical detection, length differences and terminating bases of strands of DNA. In this Colloquium we review several physical approaches to DNA detection that have the potential to deliver fast and low-cost sequencing. Center-fold to these approaches is the concept of nanochannels or nanopores which allow for the spatial confinement of DNA molecules. In addition to their possible impact in medicine and biology, the methods offer ideal test beds to study open scientific issues and challenge...