MRI findings of the brain in high-voltage electrical burn patient: case report
Energy Technology Data Exchange (ETDEWEB)
We report the delayed sequelae arising in a case of electrical injury, reviewing the literature on the subject and focusing on the MRI findings of the brain. A 23-year-old male suffered burns to the left parietal scalp, both feet, and the anterior chest wall. Neurological symptoms and MRI abnormalities appeared 14 days after the insult and continued for about three months. T1-weight MR images demonstrated homogeneous hypointensity, while T2-weighted images depicted hyperintense finger-like projections. Contrast-enhanced T1-weighted images demonstrated strong band-like enhancement, indicating meningeal hyperemia. Follow-up MR imaging showed that the lesion had disappeared, indicating that the cerebral edema and meaningeal hyperemia were reversible.
2003-05-01
International Nuclear Information System (INIS)
Forty-four patients with small cell carcinoma of the bronchus underwent CT and MR studies of the brain to detect cerebral metastases. All patients were studied with contrast-enhanced CT scans, short (T1-weighted) and long (T2-weighted), spin-echo (SE) and FLASH 90 grades sequences were also obtained. A quantitative comparison of the results was carried out to assess the sensitivity of the different techniques in the detection of brain metastases according to lesion diameter. Metastases were identified in 19/44 patients (43%). All techniques detected the lesions >2 cm; of the metastases <2 cm, 63/124 (51%) were detected only by GdDTPA SE-T1 and FLASH sequences and 11 more (9%) only by Gd-DTPA SE-T1 scans. All the lesions identified oh enhanced CT scans or on T2-weighted images were easily detected by Gd-DTPA scans. CT sensitivity was higher than that of pre-contrast SE-T1 and FLASH studies and only ...
1991-01-01
Bevacizumab as a treatment option for radiation-induced cerebral necrosis
International Nuclear Information System (INIS)
Radiation necrosis of normal CNS tissue represents one of the main risk factors of brain irradiation, occurring more frequently and earlier at higher total doses and higher doses per fraction. At present, it is believed that the necrosis results due to increasing capillary permeability caused by cytokine release leading to extracellular edema. This process is sustained by endothelial dysfunction, tissue hypoxia, and subsequent necrosis. Consequently, blocking the vascular endothelial growth factor (VEGF) at an early stage could be an option to reduce the development of radiation necrosis by decreasing the vascular permeability. This might help to reverse the pathological mechanisms, improve the symptoms and prevent further progression. A patient with radiation-induced necrosis was treated with an anti-VEGF antibody (bevacizumab), in whom neurologic signs and symptoms improved in accordance with a decrease in T1-weighted ...
2011-02-01
Effect of vasopressin on ependymal and capillary permeability to tritiated water in cat
Energy Technology Data Exchange (ETDEWEB)
Ependymal cells line the cerebral ventricles forming the interface that separates the cerebrospinal (CSF) and interstitial fluids (ISF). Extracellular molecules move between ependymal cells, whereas lipid soluble molecules pass both between and through cells. We measured the transfer of tritiated water (TOH) from CSF to blood across the ependymal and capillary interfaces by ventriculocisternal (VC) steady-state tissue clearance. Adult cats anesthetized with pentobarbital sodium underwent VC perfusion with the extracellular marker (/sup 14/C)sucrose and TOH added to the artificial CSF. Brain tissue was analyzed for depth of penetration of the isotopes into periventricular gray matter. We found that TOH distribution space was lower than expected from water content measurements, whereas sucrose space was normal. Using VC steady-state equations we calculated an ependymal permeability that was similar to the permeability of the ...
1986-09-01
International Nuclear Information System (INIS)
Three dimensional data of brain from the formalin-fixed fetuses were collected without isolation, by the 4.7 tesla super high magnetic field MRI and the developmental process of the cerebral parenchyma was studied by 3D images. Subjects were 13 fetal brain and MRI was performed using 3D-steady-state free precession sequence. The isolated brain is very soft and fragile and is deformed by its weight at the imaging. However 3D-MRI can be obtained without isolation, and the deformation is remarkably small. The subependymal germinal matrix layer did not be observed in 7 weeks-old fetus, appeared at 9 weeks-old and increased gradually. Then it rapidly reduced from 28 weeks-old. The volume calculated, from 3D-MRI, increased rapidly from 9 weeks-old to 23 weeks-old, and reached the maximum (2.346 mm"3) at 23 weeks-old. The relation between fetal ages and volume of cerebral ventricle also showed similar pattern. This method will be ...
1999-10-01
International Nuclear Information System (INIS)
Objective: To analyze the characteristics of external hydrocephalus in infancy with MR imaging, and to explore the cause of accumulation of extracerebral fluid and the relation with brain development. Methods: Conventional magnetic resonance T_1 weighted imaging (T_1WI) and T_2 weighted imaging (T_2WI) were performed in 46 infants aged 2 years or younger with external hydrocephalus (EH), and the results were analyzed. They were divided into 7 age groups. The width of extractable space was measured on T_2WI and compared with normal standard. Results: EH mainly resulted from infection, subdural hematoma or subarachnoid hemorrhage, HIE, which were 67.4% (31/46 cases) of the cases; EH with unknown cause were 26.1% (12/46 cases). EH was mainly located at the foreside of cerebral convexity, of which 80.4% (37/46 cases )was predominantly in the subarachnoid space, 8.7% (4/46 cases) in subdural space, 10.9% was ...
2006-05-01
Cranial MRI of neurologically impaired children suffering from neonatal hypoglycaemia
International Nuclear Information System (INIS)
Background. Metabolic disturbances such as anoxia and hypoglycaemia are important in causing maldevelopment of the neonatal brain. While there have been some pathology studies of the effects of neonatal hypoglycaemia on brain development, reports of MRI findings in such infants have been rare. Objectives. To describe the MRI findings in neurologically handicapped children who had suffered from neonatal hypoglycaemia and to evaluate the relationship between the neurological impairment and neonatal hypoglycaemia. Materials and methods. We retrospectively evaluated the MRI findings in eight full-term infants with neonatal symptomatic hypoglycaemia who later exhibited neurological handicap. The age at which the MRI scans were obtained ranged from 9 months to 8 years 10 months (mean 4 years 1 month, median 4 years). Results. The most striking findings were prolonged T1 weighting and T2 weighting in the parieto-occipital ...
1999-01-01
In vitro MRI of brain development
International Nuclear Information System (INIS)
In this review, we demonstrate the developmental appearance, structural features, and reorganization of transient cerebral zones and structures in the human fetal brain using a correlative histological and MRI analysis. The analysis of postmortem aldehyde-fixed specimens (age range: 10 postovulatory weeks to term) revealed that, at 10 postovulatory weeks, the cerebral wall already has a trilaminar appearance and consists of: (1) a ventricular zone of high cell-packing density; (2) an intermediate zone; (3) the cortical plate (in a stage of primary consolidation) with high MRI signal intensity. The anlage of the hippocampus is present as a prominent bulging in the thin limbic telencephalon. The early fetal telencephalon impar also contains the first commissural fibers and fornix bundles in the septal area. The ganglionic eminence is clearly visible as an expanded continuation of the proliferative ventricular zone. The basal ganglia showed an ...
2006-02-01
MRI of normal fetal brain development
International Nuclear Information System (INIS)
Normal fetal brain maturation can be studied by in vivo magnetic resonance imaging (MRI) from the 18th gestational week (GW) to term, and relies primarily on T2-weighted and diffusion-weighted (DW) sequences. These maturational changes must be interpreted with a knowledge of the histological background and the temporal course of the respective developmental steps. In addition, MR presentation of developing and transient structures must be considered. Signal changes associated with maturational processes can mainly be ascribed to the following changes in tissue composition and organization, which occur at the histological level: (1) a decrease in water content and increasing cell-density can be recognized as a shortening of T1- and T2-relaxation times, leading to increased T1-weighted and decreased T2-weighted intensity, respectively; (2) the arrangement of microanatomical structures to create a symmetrical or asymmetrical ...
2006-02-01
UK PubMed Central (United Kingdom)
We offer a plausible interpretation of some experiments on the reversal of neoplastic transformations in plants. We suggest that normal cells and tumorous cells represent multiple stable-steady states...Full Text Available
1991-12-01
Modeling and steady-state analysis for a horizontal steam generator
International Nuclear Information System (INIS)
This paper studied the mathematical model in the steady state for the horizontal steam generator, and based on this study, the thermal-hydraulics analysis code HSG-S for the HSG had been developed, and the steady state calculation had been preformed. The results were correct and fit well with RELAP5 results
2004-06-01
International Nuclear Information System (INIS)
The authors compared unenhanced and contrast-enhanced fast MRI and Computerized Tomography in the detection of liver metastases. Eleven patients with single or multiple hepatic lesions (42 in all) were submitted to V and magnetic resonance studies; T1- and T2- weighted TSE, T2-weighted TSE with fat suppression, unenhanced breath-hold TFE and early or delayed enhanced breath-hold TFE images were acquired with a 1.5 T superconductive magnet (Philips NT). The quantitative analysis of all magnetic resonance images was performed for contrast/noise ratio (CNR) and number of detected lesions; magnetic resonance and Computerized Tomography images were also compared qualitatively for lesion conspicuity, anatomical structure identification and artifacts. The results were compared with Student's test. Early enhanced breath-hold TFE was statistically superior to T1-weighted TSE (p = .0009), T2-weighted TSE (p = .01) and Computerized ...
1997-01-01
Energy Technology Data Exchange (ETDEWEB)
The results of the development work to improve the horizontal steam generator modelling using the CATHARE code as well as the results of the steady-state and the steam-line break calculations are presented. Also the results of the steady-state calculations are compared to the measurements performed in operating VVER power plants. (9 refs., 6 figs., 2 tabs.).
1993-12-31
International Nuclear Information System (INIS)
The results of the development work to improve the horizontal steam generator modelling using the CATHARE code as well as the results of the steady-state and the steam-line break calculations are presented. Also the results of the steady-state calculations are compared to the measurements performed in operating VVER power plants. (9 refs., 6 figs., 2 tabs.).
1992-09-29
Quantitative cerebral blood flow with Optical Coherence Tomography
UK PubMed Central (United Kingdom)
Absolute measurements of cerebral blood flow (CBF) are an important endpoint in studies of cerebral pathophysiology. Currently no accepted method exists for in vivo longitudinal...Full Text Available
2010-02-01
MRI with pathogenic correlation of small renal cell carcinoma
Energy Technology Data Exchange (ETDEWEB)
MRI, ultrasonography and angiography were performed on 24 cases with small renal cell carcinoma, and data were compared with pathological architecture type. An average diameter of cancer was 20.8 mm (10-30 mm). Each tumor was pathologically classified into four architecture types: alveolar type (15 cases), papillary type (5 cases), tubular type (3 cases) and cystic type (1 case). In comparison with renal cortex alveolar type renal cell carcinoma showed equal or low signal in T1-weighted images and equal or high signal in T2-weighted images. Papillary and tubular types showed high signal in T1-weighted images, and low signal in T2-weighted images. In alveolar type, many cases showed equal echo in ultrasonography and hypervascularity in angiography, and in papillary and tubular types, many cases showed high echo and hypovascularity. There were many cases with ...
1999-11-01
International Nuclear Information System (INIS)
The MRI and CT appearances in 48 patients with histologically confirmed benign and malignant pleural abnormalities were compared retrospectively. Abnormal pleural changes were shown in 47 out of the 48 patients by high signal intensity of the pleura in T_2-weighted sequences and in contrast enhanced T_1-weighted sequences on MRI. CT showed abnormalities in 45 out of 48 patients. Delineation of pleural and pulmonary changes by CT was possible in 13 out of 23 cases, and pleural disease from effusions in 15 out of 28 cases. T_2-weighted MRI was successful in 14 out of 23 and 4 out of 28 cases, respectively. T_1-weighted images after contrast were successful in 20 out of 23 and 22 out of 28 cases, respectively. Indications of malignant pleural disease were the presence of mediastinal or circumferential involvement or involvement of the entire pleura, thickness of ...
Usefulness of MRI in diagnosis of hepatocellular carcinoma (HCC)
Energy Technology Data Exchange (ETDEWEB)
Sixty-six cases of histologically proven hepatocellular carcinomas (HCC) were studied by MRI. Detectability was better by MRI than by CT, especially in the tumor under 2 cm in diameter. The capsule was detected in all cases of HCC over 3 cm in diameter. The capsule was able to be diagnosed only by dynamic MRI study in some cases. High intensity on the T1-weighted image and iso or low intensity on the T2-weighted image suggested that the nodule was adenomatous hyperplasi (AH) or well differentiated HCC. MRI is concluded to be an essential modality in the diagnosis of HCC. (author).
1992-06-01
MR imaging in neuroborreliosis of the cervical spinal cord
Energy Technology Data Exchange (ETDEWEB)
The central nervous system is involved in 10-20% of cases in Lyme disease. The neurological symptoms, time course of the disease and imaging findings are multifaceted. We report two patients with cervical radiculitis. Magnetic resonance imaging revealed strong enhancement of the cervical nerve roots on contrast-enhanced T1-weighted images. These imaging patterns of borrelia-associated radiculitis have not been reported before. Knowledge of these imaging features may help to diagnose neuroborreliosis, which presents with non-specific symptoms. (orig.)
2004-11-01
Diagnosis of peanut inhalation by MRI
International Nuclear Information System (INIS)
We describe a 16-month-old boy presenting with stridor and fever. The chest X-ray suggested inhalation of a foreign body but here was no history of this. A high spot a T_1-weighted chest MRI was due to a peanut which was seen to have moved from the right main bronchus to the left inferior bronchus, between the two MRI studies. MRI can provide information on position and size of the peanut, the conditons of the surrounding tissues and may be also useful in treatment. We consider MRI to be a valuable new method for the diagnosis of peanut inhalation. (orig./GDG).
1992-01-01
Appearance of normal brain maturation on 1.5-T MR images
International Nuclear Information System (INIS)
To investigate the pattern of normal white-matter maturation as demonstrated by high-field-strength MR imaging, 82 normal infants were examined using a 1.5-T unit with spin-echo T1-weighted and T2-weighted pulse sequences. The infants ranged in age from 4 days to 2 years. The scans were assessed for qualitative changes of white matter relative to gray matter and correlated with the patient's age in 14 anatomic areas of the brain. The MR images showed that changes of brain maturation occur in an orderly manner, commencing in the brain stem and progressing to the cerebellum and the cerebrum. Changes from brain myelination were seen earlier on T1-weighted images than on T2-weighted images, possibly because of T1 shortening by the components of the developing myelin sheaths. The later changes on the T2-weighted images correlated best with the development of ...
Variable elimination in chemical reaction networks with mass action kinetics
We consider chemical reaction networks taken with mass action kinetics. The steady states of such a system are solutions to a system of polynomial equations. Even for small systems the task of finding the solutions is daunting. We develop an algebraic framework and procedure for linear elimination of variables. The procedure reduces the variables in the system to a set of "core" variables by eliminating variables corresponding to a set of non-interacting species. The steady states are parameterized algebraically by the core variables, and a graphical condition is given for when a steady state with positive core variables necessarily have all variables positive. Further, we characterize graphically the sets of eliminated variables that are constrained by a conservation law and show that this conservation law takes a specific form.
2011-01-01
International Nuclear Information System (INIS)
In this paper, steady-state isotopic transient kinetic analysis (SSITKA) is used to study two model reactions, CO oxidation and CO-NO reactions, on a typical formulation of a three-way auto-catalyst. Under steady-state conditions, abrupt switches in the isotopic composition of CO ("1"2C"1"6O/"1"3C"1"8O) were carried out to produce isotopic transients in both labeled reactants and products. Along with the determination of the average surface lifetimes and concentrations of reaction intermediates, an analysis of the transient responses along the carbon reaction pathway indicated that the distribution of active sites for the formation of CO_2 was bimodal for both reactions. Furthermore, relatively few surface sites contributed to the overall reaction rate.
1991-08-25
Steady-state passive films; Interfacial kinetic effects and diagnostic criteria
Energy Technology Data Exchange (ETDEWEB)
This paper reports that the point defect model for steady-state passive films formed anodically on metal s in aqueous environments has been extended to include irreversible dissolution of the film and the irreversible generation and annihilation of cation and oxygen vacancies at the metal/film and film/solution interfaces. THe model yields a number of diagnostic criteria that can be used to identify the majority (vacancy) charge carrier and to characterize the kinetic nature of the interfacial vacancy generation and annihilation processes. We use these criteria to show that the steady-state passive film that forms on nickel in acidic phosphate buffer solutions is a cation conductor and that cation transport from the metal to the solution involves irreversible ejection of cations from the film. On the other hand, the passive film that forms on tungsten in the same environment under steady-state conditions is found to be an ...
1992-01-01
Simulation of natural circulation in PGV-1000 steam generator
Energy Technology Data Exchange (ETDEWEB)
The PGV-1000 secondary side natural circulation calculation results for steady-state operational conditions and their analysis using the data of actual NPP circulation investigation are presented. (3 refs., 3 figs., 3 tabs.).
1993-12-31
Simulation of natural circulation in PGV-1000 steam generator
International Nuclear Information System (INIS)
The PGV-1000 secondary side natural circulation calculation results for steady-state operational conditions and their analysis using the data of actual NPP circulation investigation are presented. (3 refs., 3 figs., 3 tabs.).
1992-09-29
UK PubMed Central (United Kingdom)
A combined approach based on the use of ATR-FT/IR and steady-state fluorescence spectroscopy allowed to shed light on the effects of the additive methoxypolyethylene glycol (MePEG) on the hydration,...Full Text Available
2008-10-01
Program listing for heat-pump seasonal-performance model (SPM). [CNHSPM
The computer program CNHSPM is listed which predicts heat pump seasonal energy consumption (including defrost, cyclic degradation, and supplementary heat) using steady state rating point performance and binned weather data. (LEW)
1982-06-30
Photosynthesis by sugar-cane leaves
UK PubMed Central (United Kingdom)
1. Radioactive products in detached leaf segments were examined after periods of steady-state photosynthesis in 14CO2. 2. After exposure to 14CO2 for approx....Full Text Available
1966-10-01
UK PubMed Central (United Kingdom)
The pharmacokinetics of oral fluoroquinolone antibiotics in normal volunteers have been studied extensively; however, limited patient data exist. Enoxacin steady-state pharmacokinetics and bioavailability...Full Text Available
1990-10-01
On the Uptake of Materials by the Intact Liver THE CONCENTRATIVE TRANSPORT OF RUBIDIUM-86
UK PubMed Central (United Kingdom)
In this study we use the multiple indicator dilution technique to outline the kinetic mechanisms underlying the uptake of rubidium, a cation which, in the steady state, is concentrated by hepatic parenchymal...Full Text Available
1973-05-01
Modeling and field studies of radon-222 in geothermal reservoirs
Radon-222 was shown to be useful in-situ tracer for studying thermodynamic, geologic, and transport properties of geothermal reservoirs. The relationships to reservoir properties are based on steady-state and non-steady-state models which incorporate the thermodynamic state and relative mobility of the fluids, and partitioning between the fluid phases. The steady-state thermodynamic models assume equilibrium between radon emanation from the reservoir rock and the geofluid concentration. The non-steady-state model solves the partial differential equations describing radon transport under transient two-phase geothermal flow conditions. Radon concentrations of fluids from nine geothermal reservoirs showed strong correlations to the specific volume of the reservoir fluid. Lowest values were associated with all-liquid wells at Cerro Prieto, Wairakei, and Los Azufres reservoirs, and the highest values for ...
1986-01-01
UK PubMed Central (United Kingdom)
The percentages of total airflows over the nasal respiratory and olfactory epithelium of female rabbits were calculated from computational fluid dynamics (CFD) simulations of steady-state inhalation....Full Text Available
2009-05-01
UK PubMed Central (United Kingdom)
Growth of Lactococcus lactis subsp. lactis biovar diacetylactis was observed on media with citrate as the only energy source. At pH 5.6, steady state was achieved in...Full Text Available
1993-12-01
Construction of a Continuous Wave Frequency Modulation ...
... Steady State 16.0-28.0 5.05 to 5.36 0 Key switch turned on. ... version may have been the better choice since the acousto-optic modulator also ...
1997-03-01
Can treadmill walking be used to assess propulsion generation?
UK PubMed Central (United Kingdom)
Instrumented treadmills offer significant advantages for analysis of human locomotion, including recording consecutive steady-state gait cycles, precisely controlling walking speed, and avoiding...Full Text Available
2008-01-01
Calcium Effects on Stomatal Movement in Commelina communis L. 1
UK PubMed Central (United Kingdom)
Stomatal movements depend on both ion influx and efflux; attainment of steady state apertures reflects modulation of either or both processes. The role of Ca2+ in those two processes was...Full Text Available
1988-07-01
Convection in the cavity between two rollers: The effect of thermal boundary conditions
Energy Technology Data Exchange (ETDEWEB)
In this study the authors examine the convective cooling provided by fluid trapped in the cavity between two consecutive rollers in a roller bearing. In order to calculate the steady-state temperature of the roller, the designer must know nor only the rolling-contact heat input received by the roller but also the convection cooling effect of the surrounding fluid. Until recently, this lateral convection cooling effect was modeled by assuming a certain (constant) heat transfer coefficient h at the roller surface, and then calculating the steady-state temperature distribution around the roller.
1991-02-01
Energy Technology Data Exchange (ETDEWEB)
This work describes a procedure for the adaptive time dependent Finite Element Method using an automatic mesh refinement (H-Version) that efficiently reduces estimated errors ( a posteriori) below pre-assigned limits. Classical model problem for steady-state heat transfer are investigated, and the results are compared with the analytical solution. Then some typical time-dependent problem are qualitatively analysed. (author) 10 refs., 7 figs.
1990-12-31
Energy Technology Data Exchange (ETDEWEB)
This report uses experimental data to compare the performance of two sodium cooled solar central receivers operated at the International Energy Agency Small Solar Power Systems project near Almeria, Spain. Performance includes point-in-time steady state efficiency, average efficiency, start-up time, and operation time. Point-in-time steady state efficiency calculations were based on the statistical method of least squares using receiver incident and absorbed powers. One receiver, a cavity type, showed a peak steady state receiver efficiency of 87% +- 5% and an average efficiency of about 67%. The other receiver, an external ''billboard'' type, had a peak steady state receiver efficiency of 96% +- 4% and an average efficiency of about 79%. The original design peak ...
1987-10-01
Nodular fasciitis: correlation of MRI findings and histopathology
Energy Technology Data Exchange (ETDEWEB)
Objective: To compare the histopathology of nodular fasciitis (NF) with the magnetic resonance imaging (MRI) findings in order to evaluate the basis of the MR signal characteristics. Design and patients: Ten patients with NF, nine females and 1 male, with an age ranging from 13 to 58 years (mean 26.8 years) were studied. MRI findings, available in all 10 patients, were compared with the histopathology in nine patients, and an area-to-area comparative study of the whole specimen section histopathology and MRI was performed in two patients. Results: On the basis of an excisional biopsy or resection specimen, the nine lesions were classified into myxoid (n=4), cellular (n=3) and fibrous (n=2) subtypes. Four myxoid lesions with a subcutaneous location showed a homogeneous SI comparable with muscle on T1-weighted images, high SI on T2-weighted images, and had homogeneous enhancement. One cellular lesion presented with ...
2002-03-01
UK PubMed Central (United Kingdom)
The major neuropathological correlate of cerebral palsy in premature infants is periventricular leukomalacia (PVL), a disorder of the immature cerebral white matter. Cerebral ischemia leading...Full Text Available
2008-05-10
UK PubMed Central (United Kingdom)
Cerebral malaria is the most severe complication of human infection with Plasmodium falciparum. It was shown that Plasmodium berghei ANKA-induced cerebral malaria was...Full Text Available
2010-09-01
Role of MRI in the diagnostic evaluation of parotid diseases
International Nuclear Information System (INIS)
MRI findings in 13 patients with monolateral parotid tumor were compared with US, sialographic and CT findings. MRI did not allow an accurate diagnosis in 2 patients with diffuse chronic parotitis. MRI was superior to CT in 1 case in defining the intraglandular site of the lesion, and in 2 patients in showing the extraglandular involvement. MRI proved to be superior to CT thanks to its contrast resolution and to multiplanar imaging. MRI high contrast resolution made it possible to demonstrate neoplastic lesions of 4 mm in diameter. The lesion has low signal intensity on T1-weighted images and high signal intensity on T2-weighted. Parotid tumors cannot be characterized by signal intensity alone: only morphology allows to discriminate between benign and malignant lesions. To conclude, US is a screening method, while MRI is helpful in detecting multifocal lesions and in evaluating the tumor extent.
1988-01-01
Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain
British Library Electronic Table of Contents (United Kingdom)
Summary Status epilepticus or other brain-damaging insults launch a cascade of events that may lead to the development of epilepsy. MRI techniques available today, including T2- and T1-weighted imaging, functional MRI, manganese enhanced MRI (MEMRI), arterial spin labeling (ASL), diffusion tensor imaging (DTI), and phase imaging, can detect not only damage caused by status epilepticus but also plastic changes in the brain that occur in response to damage. Optimal balance between damage and recovery processes is a key for planning possible treatments, and noninvasive imaging has the potential to greatly facilitate this process and to make personalized treatment plans possible.
2011-01-01
Correlation of MRI and histomorphological findings in bone marrow oedema syndrome of the hip
Energy Technology Data Exchange (ETDEWEB)
In 15 patients (16 hip joints) we found the clinical and radiological signs of BMOS. On T1-weighted MRI images areas of low signal intensity could be observed in the head, neck and the intertrochanteric region of the femur in various extensions. These areas showed a significant increase in signal intensity on the T2-weighted images. Because pain was resistant to conservative therapy all these patients were treated by core decompression of the femoral head in a prospective study. Bone cores were evaluated histologically using undecalcified sections and quantitative microradiography. The existence of intramedullary oedema in exactly the regions exhibiting the MRI pattern of bone marrow oedema was verified histologically; however, bone and marrow changes similar to those of early avascular necrosis (AVN) were also visible. (orig.)
1993-10-01
A Fuzzy System for Helping Medical Diagnosis of Malformations of Cortical Development
UK PubMed Central (United Kingdom)
Malformations of the cerebral cortex are recognized as a common cause of developmental delay, neurological deficits, mental retardation and epilepsy. Currently, the diagnosis of cerebral cortical...Full Text Available
2007-06-01
Steady-state Ab Initio Laser Theory: Generalizations and Analytic Results
We improve the steady-state ab initio laser theory (SALT) of Tureci et al. by expressing its fundamental self-consistent equation in a basis set of threshold constant flux states that contains the exact threshold lasing mode. For cavities with non-uniform index and/or non-uniform gain, the new basis set allows the steady-state lasing properties to be computed with much greater efficiency. This formulation of the SALT can be solved in the single-pole approximation, which gives the intensities and thresholds, including the effects of nonlinear hole-burning interactions to all orders, with negligible computational effort. The approximation yields a number of analytic predictions, including a "gain-clamping" transition at which strong modal interactions suppress all higher modes. We show that the single-pole approximation agrees well with exact SALT calculations, particularly for high-Q cavities. Within this range of validity, it provides an ...
2010-01-01
International Nuclear Information System (INIS)
Authors obtained T1-weighted MRI images of the femoral head after fracture of the femoral neck and classified the signals into four patterns to investigate the sequential changes of the femoral head. The T1-weighted MRI images obtained initially after femoral neck fracture showed a normal pattern in 10 of the 15 hip joints studied. MRI images obtained subsequently still showed the normal signal pattern in eight of the 10 hip joints which had shown the normal pattern in the first MRI, while two of the 10 joints subsequently showed a band pattern. The joint with the homogeneous pattern in the first MRI subsequently showed a band pattern. Of the three joints with an inhomogeneous pattern in the first MRI, two joints showed a subsequent band pattern, and the other a normal pattern. The joints which showed a band pattern continued to show a similar band pattern. ...
1998-07-01
Energy Technology Data Exchange (ETDEWEB)
Objective. To compare turbo inversion recovery magnitude (TIRM) with standard T1-weighted (T1-W) and T2-weighted (T2-W) MR sequences in the very early detection of acute osteomyelitis in children. Materials and methods. In 15 children with osteomyelitis, 15 sets of T1-W spin-echo (SE) (TR/TE, 400-640/12-17), T2-W turbo spin-echo (TSE) (TR/TE/ETL, 3290-4465/112-120/11), and TIRM (TR/TE/TI, 4000-6120/60/160) images were acquired with a 1.0-T magnet. Contrast-to-noise (C/N) ratios and percentage of signal between lesion and normal bone marrow were analysed with a computer-assisted image analysing system in a region of interest (ROI). Results. In 13 of 15 patients, the absolute signal enhancement in a ROI on the TIRM images was better than on the T1-W SE and T2-W TSE images and in 14 of 15 cases, C/N ratios were also better on the TIRM images than on the other sequences. In the other cases, the TIRM signal was diagnostically ...
1998-11-01
Steady state temperature profile in a cylinder heated by microwaves
Energy Technology Data Exchange (ETDEWEB)
A new theory has been developed to calculate the steady state temperature profile in a cylindrical sample positioned along the entire axis of a cylindrical microwave cavity. Temperature profiles were computed for alumina rods of various radii contained in a cavity excited in one of the TM{sub 0n0} modes with n = 1, 2 or 3. Calculations were also performed with a concentric outer cylindrical tube surrounding the rod to investigate hybrid treating. The parametric studies of the total sample center and surface temperatures were performed as a function of the total power transmitted into the cavity. Also, the total hemispherical emissivity was varied at boundaries of the rod, surrounding tube, and cavity walls. The results are discussed in the context of controlling the average rod temperature and the temperature distribution in the rod during microwave processing.
1995-12-31
Effect of Sb addition on the creep property of AZ31 alloy
Energy Technology Data Exchange (ETDEWEB)
The effects of antimony addition on the microstructures and creep behavior of AZ31 have been studied. Constant load creep tests were carried out at 200 C and an initial stress of 50MPa for AZ31 alloys containing antimony up to 0.84% by weight. Results show that Small additions of antimony to AZ31 effectively decreased the creep extension and steady state creep rates. The steady state creep rate of AZ31 was reduced 2.5 times by the addition of 0.84% of antimony by weight. The main reason for the higher creep resistance is due to the presence of high volume fraction ({proportional_to} 20%) of second phases including Mg{sub 3}Sb{sub 2}, which effectively hindered the movement of dislocations during the elevated temperature creep. (orig.)
2004-07-01
Dynamic optimization of the benzene extractive distillation unit
Scientific Electronic Library Online (English)
Abstract in english A mathematical model has been developed for describing the dynamic operation of the N-formylmorpholine extractive distillation column and the corresponding solvent recovery column in the benzene extraction plant. The NRTL equation was used to calculate the equilibrium and thermodynamic properties of the mixtures. The validity of the model in terms of temperature, pressure and split fraction was examined using actual plant data at steady-state conditions. Comparison betwee (more) n model results and plant data shows good consistency. In order to improve the control of the process and selection of the optimal control strategy, the model was used to find the optimum values of the constants of the controllers with Nelder-Mead algorithm during unsteady-state operation by minimizing the deviation from steady-state conditions. The outcome of this study could be used by operators and engineers to increase the productivity of the ...
2008-12-01
3D modelling as a support to thermal-hydraulic safety analyses with standard codes
Energy Technology Data Exchange (ETDEWEB)
A three-dimensional (3D) thermal-hydraulic model and a numerical procedure for the simulation and analysis of a steady-state, as well as transient operation of nuclear power plant components are presented. A two-fluid approach is applied to modelling of two-phase flow. Thermal-hydraulics of a horizontal steam generator in the WWER 1000 nuclear power plant has been simulated at the full load, steady-state operation. A comparison of the numerical results with data measured at the NPP Novovoronjezh shows good agreement. 3D numerical results can be used in plant design or retrofitting, in nuclear power plant operation and safety analysis and as improvement of existing one-dimensional thermal-hydraulics models of the horizontal steam generator which are assessed by system codes used for the nuclear power plant safety analyses. (author)
1999-07-01
3D modelling as a support to thermal-hydraulic safety analyses with standard codes
International Nuclear Information System (INIS)
A three-dimensional (3D) thermal-hydraulic model and a numerical procedure for the simulation and analysis of a steady-state, as well as transient operation of nuclear power plant components are presented. A two-fluid approach is applied to modelling of two-phase flow. Thermal-hydraulics of a horizontal steam generator in the WWER 1000 nuclear power plant has been simulated at the full load, steady-state operation. A comparison of the numerical results with data measured at the NPP Novovoronjezh shows good agreement. 3D numerical results can be used in plant design or retrofitting, in nuclear power plant operation and safety analysis and as improvement of existing one-dimensional thermal-hydraulics models of the horizontal steam generator which are assessed by system codes used for the nuclear power plant safety analyses. (author)
1999-04-19
Transient burnout in flow reduction condition
International Nuclear Information System (INIS)
A transient flow reduction burnout experiment was conducted with water in a uniformly heated, vertically oriented tube. Test pressures ranged from 0.5 to 3.9 MPa. An analytical method was developed to obtain transient burnout conditions at the exit. A simple correlation to predict the deviation of the transient burnout mass velocity at the tube exit from the steady state mass velocity obtained as a function of steam-water density ratio and flow reduction rate. The correlation was also compared with the other data. (author).
Theory of bistability in the face-pumped laser with bimolecular recombination
Steady-state and transient behavior of the longitudinally pumped semiconductor laser is theoretically investigated by using a rate-equation model with distributed gain and photon density. Conditions necessary for bistable operation are derived. Dependencies of such major switching characteristics as turn-on and turn-off powers, delay, and rise times on laser parameters are examined. Influences of spontaneous radiation, impurities, and Auger recombination are studied. The results offer an explanation for the observed nonlinear behavior of face-pumped lasers.
1987-01-01
International Nuclear Information System (INIS)
Two sets of experiments have been performed in sodium with two seven pin electrically heated bundles: the first with a nominal arrangement, the second with one dummy pin enlarged 20% in diameter in peripheral position. In this paper a rapid review of experimental results and theoretical works, related to the temperature distribution in these geometries, is presented together with a short description of the developed test section technology.
1979-11-01
Stability of the advective flow in a horizontal rectangular channel with adiabatic boundaries
British Library Electronic Table of Contents (United Kingdom)
The steady-state advective flow in a long horizontal rectangular channel with rigid adiabatic boundaries in the presence of a uniform longitudinal pressure gradient is investigated. The stability of this flow with respect to perturbations of various types is studied. The dependence of the critical Rayleigh number on the Prandtl number is found for various aspect ratios.
2011-01-01
Spin Modulation in Semiconductor Lasers
We provide an analytic study of the dynamics of semiconductor lasers with injection (pump) of spin-polarized electrons, previously considered in the steady-state regime. Using complementary approaches of quasi-static and small signal analyses, we elucidate how the spin modulation in semiconductor lasers can improve performance, as compared to the conventional (spin-unpolarized) counterparts. We reveal that the spin-polarized injection can lead to an enhanced bandwidth and desirable switching properties of spin-lasers.
2010-01-01
Researches on Plasma Physics and Controlled Fusion in IPP NSC KIPT
International Nuclear Information System (INIS)
Recent results of experimental and theoretical investigations, carried out in the Institute of plasma Physics of the NSC KIPT, are presented in the report. The main problems of discussion are as follows: plasma confinement and heating in stellarators and electromagnetic traps; powerful quasi-steady-state plasma accelerators (QSPA); experiments relevant for ITER; fusion Plasma theory; methods of high temperature plasma diagnostics; plasma technology. The main prospects on the IPP investigators are discussed also.
2006-01-01
Optimization of Cs deposition in the 1/3 scale hydrogen negative ion source for LHD-NBI system
Energy Technology Data Exchange (ETDEWEB)
A compact cesium deposition system was used for direct deposition of cesium atoms and ions onto the inner surface of the 1/3 scale Hydrogen Negative Ion Source for the LHD-NBI system. A small, well defined amount of cesium deposition in the range of 3-200 mg was tested. Negative ion extraction and acceleration were carried out both in the pure hydrogen operation mode and in the cesium mode. Single Cs deposition of 3-30 mg to the plasma chamber have produced temporary 2-5 times increases of H-yield, but the yield was decreased within several discharge pulses to the previous steady-state value. Two consecutive 30 mg depositions done within a 3-5 hours/60 shot interval, produced a similar temporary increase of H-beam, but reached a larger H-yield steady-state value. Deposition of larger 0.1-0.2 g Cs portions with a 20-120 hours/150-270 shot interval improved the H-yield for a long (2-5 days) period of operation. Directed depositions of Cs to the ...
1999-12-01
Monitoring interfacial dynamics by pulsed laser techniques. [Annual report
Energy Technology Data Exchange (ETDEWEB)
Goal was developing optical methods for study of dynamic processes at the electrode/electrolyte interface. In the past year, optical second harmonic generation was used for time-resolved measurements of thallium deposition on Cu(111). The studies of carrier dynamics in photo-excited materials have involved both steady-state and picosecond time-resolved luminescence measurements following photoexcitation of the semiconductor material.
1992-12-31
In-situ maintenance of low-Z limiters in reactors
Energy Technology Data Exchange (ETDEWEB)
In a reactor environment, the surface of a limiter or wall is primarily determined by the mechanism of erosion and deposition of surface material. It should be possible to use pellet injection to reduce net erosion to zero everywhere if low-Z materials are used for the surface. Erosion rates can, in general, be minimized by large area limiters and high plasma temperatures, which transmit power to the walls with less sputtering. Under ideal steady state conditions the wall surface is dominated by metallurgical effects in the wall.
1980-01-01
From nuclear science symposium; San Francisco, California, USA (14 Nov 1973). A digital Fourier analyzer was programmed to perform reactor neutron noise analysis measurements and on-line processing of the data to obtain the steady-state reactivity. The system is suitable for recovering cross spectral density with low correlatedsignal component and for repetitive measurements with efficient use of reactor time. (auth)
1973-01-01
Depleted uranium human health risk assessment, Jefferson Proving Ground, Indiana
Energy Technology Data Exchange (ETDEWEB)
The risk to human health from fragments of depleted uranium (DU) at Jefferson Proving Ground (JPG) was estimated using two types of ecosystem pathway models. A steady-state, model of the JPG area was developed to examine the effects of DU in soils, water, and vegetation on deer that were hunted and consumed by humans. The RESRAD code was also used to estimate the effects of farming the impact area and consuming the products derived from the farm. The steady-state model showed that minimal doses to humans are expected from consumption of deer that inhabit the impact area. Median values for doses to humans range from about 1 mrem ({plus_minus}2.4) to 0.04 mrem ({plus_minus}0.13) and translate to less than 1 {times} 10{sup {minus}6} detriments (excess cancers) in the population. Monte Carlo simulation of the steady-state model was used to derive the probability distributions from which the median values were drawn. Sensitivity ...
1994-04-29
Data Qualification guidelines. Task number 90-053-0
Energy Technology Data Exchange (ETDEWEB)
Data Qualification (DQ) is a formal, technical process whose objective is to affirm that experimental data are suitable for their intended use. Although it is not possible to develop a fixed recipe for the DQ process to cover all test situations, these general guidelines have been developed for the Nuclear Engineering Section to establish a framework for qualifying data from steady-state processing. These guidelines outline the role of the DQ team providing insight into the planning and conducting of the DQ process.
1992-09-02
UK PubMed Central (United Kingdom)
Amide-linked indole-3-acetic acid (IAA) conjugates constitute approximately 90% of the IAA pool in the dicot Arabidopsis, whereas ester-linked conjugates and free IAA account for approximately...Full Text Available
2000-06-01
Bistability and hysteresis in tilted sandpiles
We show that tilting a model sandpile that has dynamic disorder leads to bistability and hysteresis at the angle of repose. Also the distribution of {\\it local slopes} shows an interesting dependence on the amount of tilt - weakly tilted sandpiles retain the quasi-continuous distributions of the steady state, while large tilt makes the distribution more discrete, with local slopes clustered round particular values. These observations are used to explain recent experimental results on avalanche shapes; we give a theoretical framework in terms of directed percolation.
2000-01-01
Study of epileptiform activity in cerebral ganglion of mud crab Scylla serrata
British Library Electronic Table of Contents (United Kingdom)
An attempt is made to induce in mud crab (Scylla serrata) epileptiform activities that resemble the generalized epileptic seizures. Cerebral ganglion of crab was exposed in situ, to a convulsant drug pentylenetetrazole (PTZ) 100?mM, for induction of seizures. Also, crabs were pretreated with antiepileptic drug viz sodium valproate (120??mol/l) to inhibit epileptiform activities. The surface electrical discharges of cerebral ganglion were recorded using Unkelscope (MIT, USA) in control as well as experimental animals. The cerebral ganglion of crab showed a pattern of high cerebral electrical discharges after PTZ treatment compared to control. The sodium valproate promoted sedative action in control and prevented PTZ-mediated epileptiform discharges. Glutamate and GABA contents in cerebral g...
2011-01-01
Energy Technology Data Exchange (ETDEWEB)
Six patients with eosinophilic granuloma were studied retrospectively in order to correlate the MRI appearances with the pathology. Ages ranged from 2 years 6 months to 11 years. The bones involved were the humerus, ulna, radius, femur, clavicle and ilium. Plain films, MRI and pathology specimens were obtained. A lytic lesion with indistinct margins, endosteal erosions and periosteal reaction was seen in all cases on plain radiographs. Bone marrow signal was decreased on T1-weighted images and increased on T2-weighted images throughout the bony lesion in all cases. T2-weighted images showed extensive soft-tissue abnormalities suggesting inflammatory changes in four cases. In two cases abnormalities were limited. Extensive changes correlated histologically with an early phase lesion. Localized minor changes were associated with a mid-phase lesion. Inflammatory soft-tissue changes could be associated with eosinophilic ...
1994-09-01
Magnetic resonance imaging of the hip with a pelvic phased-array surface coil: a technical note
Energy Technology Data Exchange (ETDEWEB)
Objective. The aim of this study was to assess the capability of high-resolution images obtained with a commercially available pelvic phased-array surface coil to demonstrate normal hip anatomy. Design. We retrospectively analyzed the oblique coronal magnetic resonance (MR) images of hips of 36 consecutive patients acquired on a 1.5-T clinical imager using a pelvic phased-array coil as a receiver, a 16-20 cm field of view, and 5 mm slice thickness. Patients. Thirty-six patients were studied, age 15-81 years. There were 20 males and 16 females. Results and conclusions. The articular cartilage, cortex, superior labrum, and iliofemoral ligament were well visualized on proton density weighted fat saturation (PDF) images. The femoral and obturator vessels, obturator nerve, and various muscles were easily seen on T1-weighted images. High-resolution imaging of the hip is achievable in a reasonable amount of time using newer ...
1998-02-01
Magnetic resonance appearance of peripheral nerve sheath tumors
International Nuclear Information System (INIS)
Magnetic resonance imaging (MRI) was used to evaluate 22 histological proven peripheral nerve sheath tumors, approximately two-thirds of which arose in the lower extremity. The histologic distribution was as follows: 12 schwannomas, 7 neurofibromas, and 3 malignant peripheral nerve sheath tumors (2 of which occurred in patients with neurofibromatosis). Most lesions demonstrated an intermediate to moderately bright signal on T_1-weighted images and were minimally inhomogeneous. All lesions were moderately bright on T_2-weighted images, again with variable inhomogeneity. The extent of the tumor was best assessed on proton-density- and T_2-weighted images. Smooth margins were noted in 19 lesions. Of the 3 remaining lesions, 2 were malignant (but had been subjected to biopsy prior to MRI), and the other lesion was a plexiform neurofibroma. MRI accurately determined the relationship between the lesions and the adjacent ...
MRT in differentiation between tumour and implant material in the postoperative sella
International Nuclear Information System (INIS)
MRT criteria have been developed to distinguish between tumour and implant material following examination of 50 patients who had transsphenoidal hypophysectomies for tumours. Judgements were based on the postoperative hormonal status and the operation notes. Following contrast injection of Gd-DTPA and using T_1 weighted spin-echo sequences, implant material appeared as sandwich-like, linear or circular structures. Residual recurrent tumour produced homogenous or non-homogenous aspects without marginal enhancement in 84% of cases. Postoperative displacement of the infundibulum to the opposite side was observed in 73% of patients with tumour remnants. Sensitivity of MRT was 70%, specificity 95%. There was a positive predictive value of 94% and a negative predictive value of 72% with an accuracy of 81%. This provides assistance in differentiating between tumour remnants and implant material. MRT is recommended as a method of ...
MR imaging of hilar cholangiocarcinoma
International Nuclear Information System (INIS)
Magnetic resonance (MR) images of 18 cases of hilar cholangiocarcinoma were evaluated to compare the effectiveness of Gd-DTPA with that of high dose contrast enhancement computed tomography (HCE-CT) in detecting the primary tumor. The primary tumor was demonstrated as having slightly low intensity compared with liver parenchyma and high intensity compared with the delated bile duct on T1-weighted images. In contrast, MRI using Gd-DTPA, which was carried out in five cases, revealed intense enhancement of the tumor. As the differentiation between cholangiocarcinoma and dilated bile duct was difficult, it was concluded that the use of Gd-DTPA improves the efficacy of MRI in diagnosing cholangiocarcinoma. Gd-DTPA was also effective in differentiating the growth pattern of the tumor: the infiltrating type was demonstrated as thickening of the wall of the bile duct, the polypoid type as a soft tissue mass in the bile duct. ...
International Nuclear Information System (INIS)
The primary aim was to evaluate delayed contrast-enhanced MRI in depicting perineural spread of hilar cholangiocarcinoma (CCC) and consequently to determine the capability of MRI/MRCP for staging CCC. Fifteen patients that underwent MRI/MRCP and surgical treatment were retrospectively included. Two radiologists evaluated MR images to assess delayed periductal enhancement, extent of bile duct stenosis, liver parenchymal and vascular involvement and presence of liver atrophy. An agreement between delayed enhancement of the bile duct walls and perineural neoplastic spread showed a very good correlation factor (0.93). The overall accuracy in detecting biliary neoplastic invasion was higher for delayed T1-weighted images (93.3%) than for the MRCP images (80%), and T1-delayed image increased the MR accuracy in assessing the neoplastic resectability (p < 0.05). MRI correctly predicted vascular involvement in 73% and liver ...
2008-10-01
Lymph node staging in cervical carcinoma: Results of high resolution MRT with phased-array coil
International Nuclear Information System (INIS)
Purpose: To determine the diagnostic value of high resolution MR imaging with a circularly polarised (c.p.) body phased-array coil for the staging of pelvic lymph nodes in cervical carcinoma. Material and methods: 42 patients with histologically proven carcinoma of the cervix were studied on a 1.5 T scanner by using a c.p. body phased-array coil. The imaging protocol included T_2-weighted turbo-spin-echo (TSE) and T_1-weighted spin-echo sequences pre and post IV application of Gd-DTPA; slice thickness was 5-7 mm and pixel size 0.53 mm"2. Lymph nodes with a diameter of #>=#8 mm were considered to have metastatic involvement. MR imaging results were compared with histopathologic findings. Results: MR imaging showed enlarged lymph nodes (#>=# 8 mm) in 16 of 18 patients with histologic proof of lymph node metastases (sensitivity 89%). In 22 of 24 cases MR findings were true negative (specificity 92%). Diagnostic accuracy ...
Ganglioneuromas in childhood: MRI and CT characteristics
International Nuclear Information System (INIS)
Purpose: The aim of this study was to demonstrate the typical appearance of ganglioneuromas in computer-assisted tomography (CT), and magnetic resonance imaging (MRI). Material and methods: Retrospective analysis of diagnostic imaging (9 CT, 6 MRI) in 9 children aged 3 to 15 years with the histological diagnosis of ganglioneuroma. Results: The tomographies showed large (max. 13.4 cm in diameter) round or oval tumors with sharp delineation. The sites of the tumors were the retroperitoneum (5), the mediastinum (3), and the adrenal gland (1). Intraspinal tumor involvement occurred in 4 cases. On comparing CT with MRI, MRI was more accurate in defining the intraspinal involvement. The ganglioneuromas were of hypodense appearance in the native CT scan and showed moderate enhancement upon administration of contrast media. In five patients tumor calcifications with a disseminated sprinkled pattern were seen in CT. In MRI ...
2000-05-01
Dura thickening adjacent to intracranial tumors on MRI. Histologically correlation
International Nuclear Information System (INIS)
Purpose: With intracranial tumors a flat, contrast-enhancing, probably dural structure adjacent to the tumor can occasionally be observed on gadolinium-DTPA enhanced MR images. Therefore we have attempted to evaluate a tumor infiltration of this enthancement on MRI. Material and Methods: This study included 50 patients. 19 patients had a dural thickening at the tumor base (13 meningiomas and 6 metastases), while 31 patients did not (12 meningiomas and 19 metastases). Studies included plane T_2-weighted spin echo (SE) images as well as T_1-weighted axial, coronal, or sagittal plains with and without contrast agent. Histopathological examinations, were done on the tumor base adjacent to the dura mater. Results: 7 of 12 meningiomas showed a meningeal thickening on MRI with histopathologically proven tumor infiltration as did also 5 of 6 metastases. But 3 of 12 meningiomas and 15 of 19 metastases without dural thickening at the ...
Approximate fuzzy C-means (AFCM) cluster analysis of medical magnetic resonance image (MRI) data
International Nuclear Information System (INIS)
The authors describe the application of an approximate fuzzy C-means (AFCM) clustering algorithm as a data dimension reduction approach to medical magnetic resonance images (MRI). Image data consisted of one T1-weighted, two T2-weighted, and one T2*-weighted (magnetic susceptibility) image for each cranial study and a matrix of 10 images generated from 10 combinations of TE and TR for each body lymphoma study. All images were obtained with a 1.5 Tesla imaging system (GE Signa). Analyses were performed on over 100 MR image sets with a variety of pathologies. The cluster analysis was operated in an unsupervised mode and computational overhead was minimized by utilizing a table look-up approach without adversely affecting accuracy. Image data were first segmented into 2 coarse clusters, each of which was then subdivided into 16 fine clusters. The final tissue classifications were presented as color-coded anatomically-mapped ...
Energy Technology Data Exchange (ETDEWEB)
Brain MRI was carried out in patients with chronic liver diseases. No abnormal findings were recognized in patients with chronic viral hepatitis, while 59.2% of cirrhotics showed a symmetrically strong signal in basal ganglia on T1 weighted image in MRI. This finding significantly related with lowered Fischer`s ratio of serum amino acid, increased levels of serum phenylalanine, tyrosine and hyaluronic acid, prolonged prothrombin time and decreased platelet counts in the peripheral blood. Overt hepatic encephalopathy was observed in 6 of 34 patients with the strong signal in MRI during follow-up period, while none of patients without that finding developed hepatic encephalopathy. These results have indicated that the strong signal in basal ganglia on MRI appears in cirrhotic patients with severe liver dysfunction, and it is an useful index in the early diagnosis of latent hepatic encephalopathy. An improvement of this MRI ...
1996-03-01
UK PubMed Central (United Kingdom)
BackgroundSeveral proteins are known to be markedly expressed in the brain during cerebral ischemia; however, the changes in protein profiles within the ischemic brain after an ischemic...Full Text Available
Measuring the thickness of the human cerebral cortex from magnetic resonance images
UK PubMed Central (United Kingdom)
Accurate and automated methods for measuring the thickness of human cerebral cortex could provide powerful tools for diagnosing and studying a variety of neurodegenerative and psychiatric disorders....Full Text Available
2000-09-26
UK PubMed Central (United Kingdom)
1. This study analyzes the mechanisms involved in the responses to ouabain in cat cerebral and femoral arteries and characterizes the electrogenic Na+ pump present in these vessels. The latter was accomplished...Full Text Available
1988-01-01
Cerebral scintigraphy--the phoenix rises again.
UK PubMed Central (United Kingdom)
This paper reviews the development of cerebral scintigraphy from its early days of planar imaging with simple technetium-99m labelled compounds to the recent revival of the technique in the form of...Full Text Available
1988-01-01
UK PubMed Central (United Kingdom)
Brain edema is frequently shown after cerebral ischemia. It is an expansion of brain volume because of increasing water content in brain. It causes to increase mortality after stroke. Agmatine, formed...Full Text Available
2010-05-01
A Rapid Murine Coma and Behavior Scale for Quantitative Assessment of Murine Cerebral Malaria
UK PubMed Central (United Kingdom)
BackgroundCerebral malaria (CM) is a neurological syndrome that includes coma and seizures following malaria parasite infection. The pathophysiology is not fully understood and cannot...Full Text Available
Energy Technology Data Exchange (ETDEWEB)
Delayed cerebral necroses after irradiation are to be divided into hemispheric and midline lesions, as they differ from each other in several aspects. Apart from the symptoms, they are differing in the duration of latency, in the course and prognosis, and also with regard to morphology. Though there is no doubt that radiation tolerance of cerebral midline structures is relatively limited, on biological grounds, evidence of a difference between the tolerated doses could not be given from the existent inhomogeneous radiation data, with the help of the NSD-concept. Radiation planning for the region of the head, nevertheless, carefully should avoid in every case to involve the structures of the cerebral midline.
1980-08-01
Changes of cerebral blood flow in patients with hepatic cirrhosis and encephalopathy
International Nuclear Information System (INIS)
1998 p. 67 Poland Jankowski, M. Lass, P. Bandurski, T. Romanowicz, G.
Cerebral artery replacement by use of arterial graft irradiated with high voltage cathode ray
International Nuclear Information System (INIS)
Japanese (Sep 1974). Japan Kudo, Susumu . Kansai Medical School,
1974-01-01
Energy Technology Data Exchange (ETDEWEB)
Sensors installed at a telephone office building in Neenah, WI, continuously monitor 24 parameters related to the operation of the building's heating, ventilating, and air conditioning (HVAC) system. This data is stored in a dedicated minicomputer and can be retrieved, in various formats, for subsequent analyses. For more than a year, we have measured indoor and outdoor concentrations of both fine and coarse airborne particles, their chemical constituents, and volatile organic compounds at this same location. Using this data, we have examined the composition of the indoor air as it correlates to the composition of the outdoor air and the various HVAC operating parameters. The steady-state indoor concentrations of the particles, particulate constituents, and organic vapors can be explained in the context of a mass balance model. This model can also be used to calculate the rate at which selected chemicals are generated within the building, as well as to ...
1989-01-01
International Nuclear Information System (INIS)
Cultures of 3T3-L1 cells were incubated with either 10 ng/ml cholera toxin or 10 ng/ml pertussis toxin from 4 days prior to the initiation of differentiation and throughout the subsequent incubation. Toxin concentrations were sufficient to completely prevent the labelling of alpha-subunits with ["3"2P]NAD"+ and pertussis toxin and to prevent by more than 90% the labelling with ["3"2P]NAD"+ and cholera toxin in membranes prepared from these cells. Neither toxin prevented the differentiation to the adipocyte phenotype. Neither toxin prevented the increases in the relative amounts of G-proteins which occur upon differentiation. Both toxins dramatically decreased the amount of beta-subunits. As measured by quantitative immunoblotting with antisera specific for both the 35 kDa and 36 kDa beta-subunits, levels of beta-subunit were decreased by more than 50% of steady-state level of control cells. Thus, bacterial toxins which modifies G-protein alpha-subunits are capable ...
1987-06-07
Steady-state film-boiling data in rod-bundle geometry and non-equilibrium correlation assessment
Energy Technology Data Exchange (ETDEWEB)
A series of 22 steady-state, rod bundle, dispersed flow film boiling experiments has been performed in the Thermal-Hydraulic Test Facility (THTF), a pressurized-water loop containing 64 full-length electrically heated rods. Test parameters in the upflow experiments cover a wide range of conditions typical of those which might be encountered during a nuclear reactor loss-of-coolant accident. Local equilibrium fluid conditions were calculated using mass and energy conservation considerations. Experimentally determined heat transfer coefficients were compared to several available film boiling heat transfer correlations: Dougall-Rohsenow, Groeneveld 5.7, Groeneveld-Delorme, Chen, Jones-Zuber, and Yoder-Rohsenow. The Groeneveld 5.7 correlation tended to predict the data better than any other correlation tested. The Dougall-Rohsenow correlation tends to overpredict the data while the Yoder-Rohsenow correlation predicted the data better than the other nonequilibrium ...
1982-01-01
Energy Technology Data Exchange (ETDEWEB)
To resolve the central thermal safety issue for spent fuel dry storage concrete canister design or Wolsung (CANDU) nuclear power plant unit 1, a thermal analysis method has been developed for the complicated geometry of rod bundles and the multi-dimensional and multi-mode heat transfer phenomena. The canister geometry is simplified and combined heat transfer by conduction, convection, and radiation is considered through effective heat transfer coefficients. Mean temperature distributions of the fuel bundles within the fuel basket are obtained by solving the heat transfer problem using an existing computer code HEATING5. The measured steady state temperature distribution within a mock-up of a storage basket is compared to the calculated result. Steady state and/or transient fuel temperature distributions have been calculated for various ambient conditions at the canister exterior surface.
1992-07-01
International Nuclear Information System (INIS)
To resolve the central thermal safety issue for spent fuel dry storage concrete canister design or Wolsung (CANDU) nuclear power plant unit 1, a thermal analysis method has been developed for the complicated geometry of rod bundles and the multi-dimensional and multi-mode heat transfer phenomena. The canister geometry is simplified and combined heat transfer by conduction, convection, and radiation is considered through effective heat transfer coefficients. Mean temperature distributions of the fuel bundles within the fuel basket are obtained by solving the heat transfer problem using an existing computer code HEATING5. The measured steady state temperature distribution within a mock-up of a storage basket is compared to the calculated result. Steady state and/or transient fuel temperature distributions have been calculated for various ambient conditions at the canister exterior surface.
1992-10-31
Osmoregulation in the Avena coleoptile: control of solute uptake in peeled sections
Energy Technology Data Exchange (ETDEWEB)
Peeled Avena sativa coleoptile sections have been used to study the control of solute uptake under conditions where the uptake is not limited by the cuticular barrier. In the presence of 2% sucrose, auxin enhances the rate at which the total osmotic solutes increase, but this appears to be a response to the increased growth rate, inasmuch as the auxin effect is eliminated when growth is inhibited osmotically. When sections are incubated in sucrose or in 10 millimolar NaCl, the osmotic concentration increases until a plateau is reached after 8 to 24 hours. Auxin has no effect on the initial rate of increase in osmotic concentration. This difference in steady-state osmotic concentration is, in part, a response to auxin itself, as it persists when auxin-induced growth is inhibited osmotically. The upper limit for osmotic concentration does not appear to be determined by the turgor pressure, inasmuch as a combination of sucrose and NaCl gave a higher plateau osmotic ...
1982-01-01
On the stability of Innovar, a neuroleptic analgesic, for cardiovascular experiments.
The effects of 0.2 and 0.5 mL/kg Innovar (a neuroleptic analgesic) on cardiovascular functions and reflexes in rabbits were measured. We recorded the effects of Innovar on arterial pressure, heart rate, respiration rate, ventricular contractility, arterial oxygen tension, as well as the drug's effects on the bradycardia and vasoconstrictor response to cigarette smoke stimulation of the nose (the so-called "nasopharyngeal reflex"). In animals given 0.2 mL/kg Innovar, all steady state cardiovascular variables had returned to pre-Innovar levels in 45 min, as had the efficacy of the nasopharyngeal reflex. In animals given 0.5 mL/kg Innovar, all steady state cardiovascular variables, except PaO2, were slightly but significantly depressed for up to 135 min after injection. The nasopharyngeal reflex returned to normal within 90 min. Because of the calmative and analgesic effects of Innovar, and its only ...
1981-11-01
Modulation of gene expression in differentiating 3T3 - L1 preadipocytes
Energy Technology Data Exchange (ETDEWEB)
3T3 - L1 cells can be induced to differentiate by exposing cell culture to a medium containing 3-isobutyl-1-methyl-xanthine together with insulin and dexamethasone. They have observed that oxalomalate (OMA) which inhibits aconitase thus blocking the citric cycle, also favours differentiation to adipocytes leading to fatty acids accumulation and increased synthesis of specific proteins. They compared the effects of 3-isobutyl-1-methyl-xanthine-insulin-dexamethasone and OMA on the steady-state levels of mRNA of c / EBP, H-ferritin and aconitase / IRE-BP. OMA does not affect the steady-state mRNA amount of C / EBP, H-ferritin and aconitase / IRE-BP but the 3-isobutyl-1-methyl-xanthine-insulin-dexamethasone mixture is able to induce a five-fold increase of mRNA levels for aconitase / IRE-BP. This is the first finding correlating iron metabolism to adipocyte differentiation. Further studies will clarify a possible role for the aconitase inhibitor ...
1997-12-31
International Nuclear Information System (INIS)
This work aims at improving the understanding of the dynamics of a Free Electron Laser (FEL) based on a storage ring. A new phenomenon of saturation by the electron bunch transverse dimensions is pointed out, during the FEL operation with a magnetic optics ''low emittance''. A part of this thesis work concerns the study of the longitudinal dynamics of the FEL depending on a parameter: the detuning between the pass frequency of the electrons and the back and return frequency of the laser pulse in the optical cavity. This study shows that the FEL presents a pulsed or a steady state behavior depending on the detuning. Besides, a spectro-temporal behavior of the FEL is pointed out showing the FEL pulse substructures and holes in the spectrum. Another part of this work concerns the response of the resonant FEL system, when a perturbation is applied on the gain. Under the effect of a modulation, the FEL can present a periodic or chaotic regime. The ...
New comparative tests on two different types of solar collectors are presented in this paper. A standard glazed flat plate collector and an evacuated tube collector are installed in parallel and tested at the same working conditions; the evacuated collector is a direct flow through type with external compound parabolic concentrator (CPC) reflectors. Efficiency in steady-state and quasi-dynamic conditions is measured following the standard and it is compared with the input/output curves measured for the whole day. The first purpose of the present work is the comparison of results in steady-state and quasi-dynamic test methods both for flat plate and evacuated tube collectors. Besides this, the objective is to characterize and to compare the daily energy performance of these two types of collectors. An effective mean for describing and analyzing the daily performance is the so called input/output diagram, in which the collected solar energy is ...
2010-08-15
British Library Electronic Table of Contents (United Kingdom)
In this study two surface sensitive methods, i.e. quartz crystal microbalance with dissipation monitoring (QCM-D) and ellipsometry, were used for erosion measurements of a rosin-based marine antifouling paint binder. Thin films of the binder were applied on sensor surfaces by the means of spin-coating and the effect of water velocity over the paint film, water temperature or ionic strength on erosion was investigated. Both the acoustic QCM-D model and the optical ellipsometry model gave comparable erosion results. The initial 2-50nm rapid erosion of the top layer was followed by steady-state erosion rate until end of experiment. For example, the steady-state erosion rate was 12nm/24h in artificial seawater at 23degreeC and with a flow of 200ml/min over the paint surface as measured with QC...
2008-01-01
BNL Neutral Beam Development Group. Progress report, FY 1983 and final report
Energy Technology Data Exchange (ETDEWEB)
The BNL Neutral Beam Development Group has been active in the program for the development of high energy, high power neutral beam systems since 1973. These injectors are based on the production, acceleration and neutralization of negative hydrogen or deuterium ions and are supposed to be used for plasma heating and current drive in the next generation of fusion devices. Over the span of 10 years the group has studied plasma-surface type of negative hydrogen ion sources, transport and acceleration of negative ion beams and neutralization of negative ions in gases and plasmas. As the required source parameters (current, pulse length, efficiency) were changing over this period of time, the group developed several types of sources, resulting finally in the design of a steady state device operating with an excellent gas efficiency and having the possibility of scaling-up to the size necessary for a high power neutral beam system. The funding of this ...
1984-03-16
Energy Technology Data Exchange (ETDEWEB)
In this article two integral computational fluid dynamics methods for steady-state and transient vehicle aerodynamic simulations are described using a Chevrolet Corvette ZR-1 surface panel model. In the last decade, road-vehicle aerodynamics have become an important design consideration. Originally, the design of low-drag shapes was given high priority due to worldwide fuel shortages that occurred in the mid-seventies. More recently, there has been increased interest in the role aerodynamics play in vehicle stability and passenger safety. Consequently, transient aerodynamics and the aerodynamics of vehicle in yaw have become important issues at the design stage. While there has been tremendous progress in Navier-Stokes methodology in the last few years, the physics of bluff-body aerodynamics are still very difficult to model correctly. Moreover, the computational effort to perform Navier-Stokes simulations from the geometric stage to complete flow solutions ...
1993-01-01
Adjoint sensitivity theory for steady-state ground-water flow
In this study, adjoint sensitivity theory is developed for equations of two-dimensional steady-state flow in a confined aquifer. Both the primary flow equation and the adjoint sensitivity equation are solved using the Galerkin finite element method. The developed computer code is used to investigate the regional flow parameters of the Leadville Formation of the Paradox Basin in Utah and the Wolcamp carbonate/sandstone aquifer of the Palo Duro Basin in the Texas Panhandle. Two performance measures are evaluated, local heads and velocity in the vicinity of potential high-level nuclear waste repositories. The results illustrate the sensitivity of calculated local heads to the boundary conditions. Local velocity-related performance measures are more sensitive to hydraulic conductivities. The uncertainty in the performance measure is a function of the parameter sensitivity, parameter variance and the correlation between parameters. Given a parameter covariance matrix, ...
1983-11-01
A dynamic model of a locomotive diesel engine and electrohydraulic governor
Energy Technology Data Exchange (ETDEWEB)
As part of a comprehensive simulation of a prototype locomotive propulsion system, a detailed model has been developed which predicts the dynamic response of an experimental 2-stroke, turbocharged and intercooled diesel engine. Engine fueling and brake torque are computed from regression equations derived from an extensive data base. Corrections are applied to the calculated steady-state torque to account for dynamic deviations of in-cylinder trapped air-fuel ratio from the steady-state value. The engine simulation accurately represents the operation of the turbo-charger, which is gear-driven at low turbocharger speeds, and freewheels through an overrunning clutch when exhaust energy accelerates the turbocharger beyond its geared speed. Engine fueling level, ie, rack, is determined from a dynamic simulation of an electrohydraulic governor which responds to the difference between the desired and the actual engine speeds. The governor ...
1988-01-01
Energy Technology Data Exchange (ETDEWEB)
We report a patient who developed occlusion of the intracranial major arteries induced by radiation therapy for craniopharyngioma. The patient, a 9-year-old boy, presented with deterioration of vision, nausea and vomiting. He underwent a right ventriculo-peritoneal shunt operation, and the tumor was partially removed. Postoperatively, he received focal radiation therapy with total of 60 Gy. Preoperative cerebral angiography, cerebral vessels had no sigh of occlusive lesion or stenosis. One year after irradiation, he started to have repeated cerebral ischemic attacks. But no regrowth of the tumor was detected on CT scans. Two years and 8 months after irradiation, he suddenly had right hemiparesis. Cerebral angiography revealed severe stenosis of the right anterior cerebral artery (precommunicating segment), middle cerebral artery (horizontal portion) and terminal ...
1994-10-01
International Nuclear Information System (INIS)
We report a patient who developed occlusion of the intracranial major arteries induced by radiation therapy for craniopharyngioma. The patient, a 9-year-old boy, presented with deterioration of vision, nausea and vomiting. He underwent a right ventriculo-peritoneal shunt operation, and the tumor was partially removed. Postoperatively, he received focal radiation therapy with total of 60 Gy. Preoperative cerebral angiography, cerebral vessels had no sigh of occlusive lesion or stenosis. One year after irradiation, he started to have repeated cerebral ischemic attacks. But no regrowth of the tumor was detected on CT scans. Two years and 8 months after irradiation, he suddenly had right hemiparesis. Cerebral angiography revealed severe stenosis of the right anterior cerebral artery (precommunicating segment), middle cerebral artery (horizontal portion) and terminal ...
1994-01-01
Toward a rule-based biome model
Energy Technology Data Exchange (ETDEWEB)
Current projections of the response of the biosphere to global climatic change indicate as much as 50% to 90% spatial displacement of extratropical biomes. The mechanism of spatial shift could be dominated by either (1) competitive displacement of northern biomes by southern biomes, or (2) drought-induced dieback of areas susceptible to change. The current suite of global biosphere models cannot distinguish between these two processes, thus determining the need for a mechanistically based biome model. The model is in an early stage of development and will require several enhancements, including explicit simulation of potential evapotranspiration, extension to boreal and tropical biomes, a shift from steady-state to transient dynamics, and validation on other continents.
1991-01-01
Thermal transfer augmentation by electroconvection
Energy Technology Data Exchange (ETDEWEB)
Measurements of the rate of heat transfer, enhanced by electroconvection, between two parallel plates have been carried out. Results show that the non-dimensional heat flux, or the Nusselt number, increases when an electric field acts on an injected space charge within the insulating liquid. The motion of the liquid depends on the electrical forces (Coulomb force) and the buoyancy effects have little or no influence. This is evident from steady state and time dependent results which show that for a given voltage, the Nusselt number takes the same value no matter what the flux of heat supplied to the bottom plate.
1987-09-01
The reversed-field-pinch (RFP) fusion neutron source: A conceptual design
Energy Technology Data Exchange (ETDEWEB)
The conceptual design of an ohmically heated, reversed-field pinch (RFP) operating at /approximately/5-MW/m/sup 2/ steady-state DT fusion neutron wall loading and /approximately/124-MW total fusion power is presented. These results are useful in projecting the development of a cost effective, low input power (/approximately/206 MW) source of DT neutrons for large-volume (/approximately/10 m/sup 3/), high-fluence (3.4 MW yr/m/sup 2/) fusion nuclear materials and technology testing. 19 refs., 15 figs., 9 tabs.
1989-01-01
Energy Technology Data Exchange (ETDEWEB)
An analytical study of the ice-formation process associated with heat-conducting plates located perpendicularly to isothermally heated and cooled surfaces with some clearance is presented. It is proposed that the onset conditions, which describe whether the ice-volume fraction in a steady state is greater than or less than that without heat-conducting plates, are defined by the dimensionless distances between the heated/cooled walls and the heat-conducting plates. It is shown that the onset conditions are dependent on the pitch and the thickness of the heat-conducting plates and are less dependent on the thermal conductivity of the plates.
1994-07-01
The fluorescence properties and NMR analysis of protopine and allocryptopine
International Nuclear Information System (INIS)
The fluorescence properties of protopine and allocryptopine in aqueous and organic environments are described for the first time. The fluorescence of alkaloids and their pH-dependent interconversion to cationic forms (transannular interaction) were studied using steady-state and time-resolved fluorescence techniques. For the analysis of tricyclic base and cis/trans tetracyclic cations of the alkaloids, NMR and X-ray crystallography were used. - Highlights: ? We describe fundamental fluorescence characteristics of alkaloids protopine and allocryptopine. ? We analyzed the pH-dependent transitions and cis/trans isomerization. ? These two alkaloids can be better distinguished by their fluorescence decay characteristics. ? The fluorescence parameters are related to the NMR and crystallographic structural data.
2011-07-01
The Formation of Multipoles during the High-Temperature Creep of Austenitic Stainless Steels
DEFF Research Database (Denmark)
It is shown that multipole dislocation configurations can arise during power-law creep of certain austenitic stainless steels. These multipoles have been analysed in some detail for two particular steels (Alloy 800 and a modified AISI 316L) and it is suggested that they arise either during instantaneous loading or during the primary creep stage. Trace analysis has shown that the multipoles are confined to {1 1 1} planes during primary creep but are not necessarily confined to these planes during steady-state creep unless they are pinned by interstitials.
1981-01-01
Testing of the 1-MWth bench-model cavity-receiver steam generator
A schematic of the Bench cavity receiver system is given, and the primary objectives, schedule and research plan for each of four tests are discussed. The tests are: (1) cold flow testing to functionally check all valves and their response using high pressure nitrogen gas; (2) a hot checkout to simulate both steady state and transient flux inputs to the receiver which are expected at the French facility; (3) basic performance using solar energy at the French facility; and (4) ir radiant heat testing. (LEW)
Energy Technology Data Exchange (ETDEWEB)
The effect of heat transfer is described from heat exchange tubes of a horizontal steam generator on the distribution of primary water to the individual tubes of the tube bundle. It is shown that in a broad interval of mass flow rates and lengths of heat exchange tubes, the simplified method of calcualtion, i.e., calculation of the distribution of primary water into heat exchange tubes neqlecting the changes of physical properties of water along the heat exchange tubes, will yield sufficiently accurate results.
1982-10-01
International Nuclear Information System (INIS)
The effect of heat transfer is described from heat exchange tubes of a horizontal steam generator on the distribution of primary water to the individual tubes of the tube bundle. It is shown that in a broad interval of mass flow rates and lengths of heat exchange tubes, the simplified method of calcualtion, i.e., calculation of the distribution of primary water into heat exchange tubes neqlecting the changes of physical properties of water along the heat exchange tubes, will yield sufficiently accurate results. (author).
1982-01-01
Energy Technology Data Exchange (ETDEWEB)
For light water reactors, loss of coolant is an important point in safety analysis, whereas for gas-cooled reactors the ingress of water into the core region is an incident of safety relevance. The applicability of the computer code system GAMTEREX to pebble beds of spherical high-temperature gas-cooled reactor fuel elements with simulated water ingress is verified by experiment. The measurements were performed at a Siemens-Argonaut reactor, using its ring core as a driver zone for a pebble-bed core in the center of the reactor.
1987-09-01
SM-2--HORIZONTAL STEAM GENERATOR ANALYSIS
ABS>A horizontal steam generator design for the SM-2 was lysis to determine the per formance of such a steam generator under steady state operating conditions and during load transients, The configuration for this design is a two- drum unit consisting of a heat exchanger unit and separator drum interconnected by integral riser and downcomer. An analog computer was used to analyze the steam generator behavior Wring load transients. The effect of various design changes on the response of the steam generator to step chages in load was determined. The horizontal steam generator design was compared to the existing vertical steam generator design for weight, size, price, and performance. (auth)
1959-11-01
On the optimal taxation of common-pool resources
British Library Electronic Table of Contents (United Kingdom)
Recent research developments in common-pool resource models emphasize the importance of links with ecological systems and the presence of non-linearities, thresholds and multiple steady states. In a recent paper Kossioris et al. (2008) develop a methodology for deriving feedback Nash equilibria for non-linear differential games and apply this methodology to a common-pool resource model of a lake where pollution corresponds to benefits and at the same time affects the ecosystem services. This paper studies the structure of optimal state-dependent taxes that steer the combined economic-ecological system towards the trajectory of optimal management, and provides an algorithm for calculating such taxes.
2011-01-01
Large scale breeder reactor pump dynamic analyses
Energy Technology Data Exchange (ETDEWEB)
The lateral natural frequency and vibration response analyses of the Large Scale Breeder Reactor (LSBR) primary pump were performed as part of the total dynamic analysis effort to obtain the fabrication release. The special features of pump modeling are outlined in this paper. The analysis clearly demonstrates the method of increasing the system natural frequency by reducing the generalized mass without significantly changing the generalized stiffness of the structure. Also, a method of computing the maximum relative and absolute steady state responses and associated phase angles at given locations is provided. This type of information is very helpful in generating response versus frequency and phase angle versus frequency plots.
1982-01-01
Improvement of the efficiency of a bare solar collector by means of turbulence promoters
Energy Technology Data Exchange (ETDEWEB)
A steady-state mathematical model was developed for a bare collector. Results obtained by previous authors for heat transfer and friction in rectangular ducts with periodic disturbances were employed to evaluate the effect of such disturbances on bare collector efficiency and on its pressure drop. An effective efficiency, which takes into account extra heat obtained and additional mechanical (electric) energy consumption for moving air when heat-transfer augmentation devices are employed, was defined. Simulation results are given for a bare collector, with and without perturbations, showing efficiency and effective efficiency dependence on collector dimensions, solar radiation intensity, disturbance diameter and pitch for collector performance optimization. (author).
1990-01-01
HVDC cable design logic for digital computers
Energy Technology Data Exchange (ETDEWEB)
The design of High-Voltage, Direct-Current transmission cables insulated with oil-impregnated cellulose paper is constrained by the maximum temperature and the maximum steady-state and transient stresses (voltage gradients) that the cable insulation can reliably withstand over the desired operating lifetime. Because the electrical stresses in the insulation are related in a very complex fashion to temperature, applied voltage and cable geometry, iterative techniques are required to compute the values of these stresses. Digital computers are ideally suited for these iterative techniques. This paper presents the principal equations and logic needed to develop suitable computer programs.
1992-10-01
International Nuclear Information System (INIS)
A series of measurements of O_3 yield in nuclear induced O_2 and O_2-SF_6 discharges created by bombardment with energetic particles from the "1"0B(n,#alpha#)"7Li reaction are reported. Continuous irradiation at dose ratios of 10"1"5-10"1"7 eV.cm"-"3.s"-"1 and pulsed irradiation (approx.10 ms FWHM) at a peak dose rate of approx.10"2"0 eV.cm"-"3.s"-"1 were conducted. At the lower dose rates, SF_6 addition generally increased the ozone yield, which at the high dose rates, SF_6 addition decreased the observed ozone concentration. A numerical model was developed and applied to experimental conditions. The steady-state ozone concentration was found to be limited by the reaction O_3"- + O_3 #-># 2O_2 + O_2"-. A simplified analytical model of steady-state conditions was used to predict model sensitivity to various parameters. In addition to dose rate effects, pressure and temperature effect on ozone production were discussed. The present study was ...
International Nuclear Information System (INIS)
Various schemes of cooling have been investigated for the purpose of assessing potential benefits on the operational characteristics of the Syrian MNSR reactor. A detailed thermal hydraulic model for the analysis of MNSR has been developed. The analysis shows that an auxiliary cooling system, installed in the pool which surrounds the lower section of the reactor vessel, will significantly offset the consumption of excess reactivity due to the negative reactivity temperature coefficient, Hence, the maximum operating time of the reactor is extended. Compared with experimental data, the suggested model proves to be valid for the analysis of MNSR behavior under both steady state and transient conditions. (author)
2007-01-01
Application of high energy ion beam for the control of boron diffusion
Energy Technology Data Exchange (ETDEWEB)
For the purpose of optimizing the process of co-implantation of MeV Si ions to reduce boron transient enhanced diffusion and boron-enhanced diffusion in Si, multiple MeV implantations and annealing at different temperatures have been performed. A slight improvement on the suppression of B diffusion is observed by adding a low temperature annealing step after the MeV implantation. No differences in B diffusion are observed when the Si doses are increased from 1 x 10{sup 15} to 1 x 10{sup 16} cm{sup -2}. This dose independent behavior is speculated to be a quasi-steady state of vacancy cluster evaporation.
2006-01-15
Application of high energy ion beam for the control of boron diffusion
International Nuclear Information System (INIS)
For the purpose of optimizing the process of co-implantation of MeV Si ions to reduce boron transient enhanced diffusion and boron-enhanced diffusion in Si, multiple MeV implantations and annealing at different temperatures have been performed. A slight improvement on the suppression of B diffusion is observed by adding a low temperature annealing step after the MeV implantation. No differences in B diffusion are observed when the Si doses are increased from 1 x 10"1"5 to 1 x 10"1"6 cm"-"2. This dose independent behavior is speculated to be a quasi-steady state of vacancy cluster evaporation.
2006-01-01
Analysis of the thermal performance of dynamic solar systems
Energy Technology Data Exchange (ETDEWEB)
This article proposes a model for estimating the effect of the overall thermal resistance of the absorber and the coolant on a solar thermal energy system utilizing advanced heat transfer mediums. Two equations can be used to model a dynamic system: one for the maximum conversion efficiency and one to specify the constraint that, in quasi-steady state, the net energy collected must be transferred to the coolant. These two equations define a constrained optimization problem in two variables, the fluid and the absorber temperatures. The results present interesting implications for liquid metal, direct absorption, and solar evaporating systems.
1996-03-01
Ampacity calculations for mixed underground cable systems in the same ductbank
Energy Technology Data Exchange (ETDEWEB)
The steady state ampacity is calculated for mixed electric power underground cable circuits in a single trench or ductbank. The methodology presented in this paper can be applied to any practical number of balanced, three phase circuits (each in trefoil, pipe or conduit) of different voltage classes, cable sizes, load currents and cable systems to located anywhere within a single trench or ductbank. The different thermal resistivities of the backfill or ductbank and the surrounding soil are taken into consideration. A practical example for 10 circuits in a trench is provided.
1994-12-31
A mathematical model for simulating shallow solar ponds for treatment of industrial wastewater
Energy Technology Data Exchange (ETDEWEB)
This paper presents a mathematical model to analyze the solar evaporation in a shallow pond in steady state, when the inlet flow rate, concentration, surface area and solar radiation are given. The simultaneous heat and mass transfer mechanisms are considered for quantifying the amount of evaporated water to the atmosphere and the actual absorbed heat by wastewater is calculated to obtain the bottom temperature of water pond. The heat losses to air by radiation and convection mechanisms are considered and the heat transmission across the water film is evaluated by the forced convection mechanism. 6 refs., 5 figs., 1 tab.
1996-12-31
A mathematical model for a thermally coupled humidification?dehumidification desalination process
British Library Electronic Table of Contents (United Kingdom)
The humidification?dehumidification process is an interesting technique that has been adapted for water desalination. Previous works experimentally investigated desalination processes in the shell and tube columns, where the humidification and dehumidification were thermally coupled and simultaneously performed at the tube and shell sides, respectively. In this work, a comprehensive steady-state mathematical model was developed for such a humidification?dehumidification desalination process by taking into account the heat and mass balances on both sides of the desalting column, the mass transfer rate at the humidification side, and the heat transfer rate between the dehumidification side and humidification side. Meanwhile, the mass transfer coefficient at the humidification side and the to...
2006-01-01
A Preliminary Analysis of SMART Reactor Core Using the COREDAX Code
International Nuclear Information System (INIS)
The 3-D neutronics code COREDAX has been developed based on AFEN (Analytic Function Expansion Nodal) method for x-y-z geometry and for hex-z geometry. In this study, the COREDAX code, as a regulatory review tool independent of the designer's, was applied to the SMART reactor core that was designed by KAERI (Korea Atomic Energy Research Institute). For nuclear cross section generation, the HELIOS lattice code was used in this study. The preliminary results for steady state in various conditions are presented in this paper
2010-10-01
Response of a non-Hodgkin lymphoma to "6"0Co therapy monitored by 31P MRS in situ
International Nuclear Information System (INIS)
High quality "3"1P MR spectra (signal to noise ratio (S/N) approximately 18, 15 min acquisition for each spectrum) were consistently obtained with surface coils over a period of 6-week RT. Both transient and steady state alterations in metabolites in response to RT were found in this case. The transient changes occurred during the first 3 hr immediately after the 3rd fractionated RT, these changes include the transient elevation of the PCr resonance, a decrease in PDE and an increase in intracellular pH. The monitoring showed that the metabolites approached steady state approximately 2 hr after the fractionated radiation intervention, suggesting that in vivo MRS can be useful for studying the dynamics of tumor response to RT such as repair of potential lethal damage, growth delay, and reoxygenation etc. The steady-state MR spectra showed the net response to each intervention and can ...
Energy Technology Data Exchange (ETDEWEB)
The present project examined the operating characteristics and application possibilities of a new, compact combined heating and electricity generating unit with a thermal output of 14,5 kW and a generating capacity of 5,5 kW. Such a module was installed in a plant in Arlesheim (Canton of Basel-Country) and subject to performance measurements. The small heating and generating plant is designed for cyclic operation (without heat storage) and is very compact and low in cost. The heating and generating unit conforms to all Swiss regulations relating to electrical installations and air pollution control. The NO{sub x} emissions of the unit (400 mg/m{sup 3} in steady state operation) are above the limits of LRV 92 (80 mg/m{sup 3}), but the regulation does not apply for units in this power range. The electricity generation costs are approximately CHF 0.16/kWh. It therefore makes sense to install the module in regions with average supply tariffs of at ...
1995-12-01
Energy Technology Data Exchange (ETDEWEB)
Biomass and nutrient dynamics of black spruce seedlings during the hardening phase of the greenhouse rotation were examined after four pre-hardening fertilization regimes - conventional, constant-rate loading, exponential loading, and high exponential loading (delivering respectively 15, 40, 40 and 60 mg N seedling{sup -1}) - in order to assess nutrient dilution and steady-state nutrition. Although height growth of seedlings had virtually ceased during hardening, shoot biomass increased 99-142% and root biomass increased five- to tenfold depending on treatment. The biomass increase compromised steady-state nutrient status by diluting internal nutrient pools as nutrient supply was unable to keep up with growth. Soil nutrient levels were rapidly depleted during this period because of plant uptake and lack of fertilizer supplementation. Pre-hardening nutrient loading partly countered and delayed dilution effects, especially when applied ...
1997-07-01
Computation and analysis of single well responses for gas condensate systems
Energy Technology Data Exchange (ETDEWEB)
A fully implicit compositional simulator was written to predict the drawdown and buildup responses for a single well in a gas condensate reservoir. The model uses the Redlich-Kwong equation of state to compute fluid properties and to determine phase equilibrium. The accuracy of the model predictions in the two-phase flow regime is tested using the results of a steady-state theory developed here. Two new correlating functions for transient flow - the reservoir integral and the sandface integral - are presented. The reservoir integral is shown to be a good liquid analogue during transient flow (drawdown). The sandface integral correlates with the liquid solution only in the slope. These two theoretical functions are shown to reduce to a computable pseudopressure function by using the results of the steady-state theory. The usefulness of this pseudopressure function for computing the permeability-thickness product and the skin factor is ...
1985-01-01
Energy Technology Data Exchange (ETDEWEB)
The reaction of ethanol on unreduced and H{sub 2}-reduced CeO{sub 2} and 1 wt% Pd/CeO{sub 2} has been investigated by steady state reactions, temperature programmed desorption (TPD), and in situ Fourier transform infrared (FT-IR) spectroscopy. Steady state reactions have shown a zero reaction order dependency for diatomic oxygen at and above 20%, while the addition of Pd to CeO{sub 2} decreases the apparent activation energy of the reaction from 75 kJ/mol on CeO{sub 2} alone to 40 kJ/mol (Pd/CeO{sub 2}). TPD experiments following ethanol adsorption on both CeO{sub 2} and Pd/CeO{sub 2} have shown desorption profiles corresponding to unreacted ethanol and various reaction and decomposition products (acetaldehyde, acetone, CO, CO{sub 2}, and methane). Ethanol conversion to reaction products was increased by the addition of Pd, from 15 to 30% on CeO{sub 2} and H{sub 2}-reduced CeO{sub 2}, to 71 and 63% on ...
1999-09-10
Energy Technology Data Exchange (ETDEWEB)
The diffusion coefficient of radioactive radon (Rn) through buffer materials from low-level radwaste disposal site was determined in this present study by measuring the time-dependent diffusion of radon through a thin slab of the material. The diffusion process was required to reach a steady state so as to obtain a good estimate of the diffusion coefficient. A numerical method using the nonlinear least-squares and Marquardt`s method (NLSM method) was proposed for characterizing the diffusion coefficient of Rn so as to determine whether the process has reached steady-state or not. Natural mordenite, a potential buffer material of LLW disposal facility, was selected as testing porous material. The NLSM method was shown by the results to be able to estimate the diffusion coefficient even if the process was in transient period. Additionally, this method was also demonstrated to agree well with the results by the conventional ...
1994-12-31
International Nuclear Information System (INIS)
Premature fusion of multiple cranial sutures has been associated with increased intracranial pressure and the potential for mental impairment. Isolated craniosynostosis, however, is considered a benign condition primarily reconstructed for aesthetic purposes. A comparative analysis, to assess the differences between pre- and post operatory cerebral perfusion of patients who underwent surgery for simple cranisynostosis, was performed using single positron emission computed tomography ''SPECT'' Images. Cerebral blood flow studies were performed using "9"9"mTc-HMPAO SPECT in children with simple cranisynotoses. The subjects were 8 children with craniosynostosis (age, 2 months-9 years). Preoperative revealed regional hypovascularity in the cerebral hemisphere in 5 cases (62%). In 6 patients the cerebral blood flow normalized or increased after craniofacial reconstruction. We demonstrated the presence of ...
1998-09-01
British Library Electronic Table of Contents (United Kingdom)
Sex steroids and thyroid hormones play a key role in the development of the central nervous system. The critical role of these hormonal systems may explain the sensitivity of the hypothalamus, the cerebral cortex, and the hippocampus to endocrine-disrupting chemicals (EDC). This review examines the evidence for endocrine disruption of glial-neuronal functions in the hypothalamus, hippocampus, and cerebral cortex. Focus was placed on two well-studied EDC, the insecticide dichlorodiphenyltrichloroethane (DDT) and polychlorinated biphenyls (PCB). DDT is involved in neuroendocrine disruption of the reproductive axis, whereas polychlorinated biphenyls (PCB) interact with both the thyroid hormone- and sex steroid-dependent systems and disturb the neuroendocrine control of reproduction and develo...
2011-01-01
In vivo MRI analysis of an inflammatory injury in the developing brain
UK PubMed Central (United Kingdom)
Cerebral periventricular white matter injury stands as a leading cause of cognitive, behavioral and motor impairment in preterm infants. There is epidemiological and histopathological evidence...Full Text Available
2010-07-01
Unsolved problems in the diagnosis and surgical treatment of intramedullary tumors
Energy Technology Data Exchange (ETDEWEB)
Problems and solutions in the diagnosis and operative treatment were clarified by retrospective evaluation of cases of intramedullary tumor in which MRI and surgery had been performed. The subjects were 16 patients (21-75 years old, mean age: 45 years) whose tumor was surgically removed between 1991 and 1998. MRI was performed preoperatively, and T1-weighted images, T2-weighted images, and enhanced images were obtained. Angiography was also performed in some cases. The histological diagnosis based on the MRI findings before surgery were compared with the pathological diagnosis after the operation. In 9/16 cases (56%), the preoperative histological diagnosis based on the MR images was the same as the pathological diagnosis after the operation. In 8 of the 11 cases (73%) whose images showed clear tumor margins and well shaped the tumor, the tumors were completely removed. The concordance rate between the pathological ...
2001-04-01
International Nuclear Information System (INIS)
The role of high-resolution computed tomography (HRCT) and magnetic resonance imaging (MRI) in the diagnosis of preoperative and postoperative complications caused by acquired cholesteatomas will be described in this paper. The pre- and postoperative imaging of the temporal bone was performed with HRCT and MRI. HRCT and MRI were performed in the axial and coronal plane. MRI was done with T2 weighted and T1 weighted sequences both before and after the intravenous application of contrast material. All imaging findings were confirmed clinically or surgically. The preoperative cholesteatoma-caused complications depicted by HRCT included bony erosions of the ossicles, scutum, facial canal in the middle ear, tympanic walls including the tegmen tympani, and of the labyrinth. The preoperative cholesteatoma-caused complications depicted by MRI included signs indicative for labyrinthitis, and brain abscess. Postoperative HRCT ...
2003-03-01
Radiologic findings of extraosseous Ewing's sarcoma
International Nuclear Information System (INIS)
The purpose of this study is to evaluate the radiologic findings of the extraosseous Ewing's sarcoma. Six patients with pathologically confirmed extraosseous Ewing's sarcoma were retrospectively reviewed. Patients included two men and four women with an average age of 21.5 years (age range 9-48 years). Plain radiographs (six patients), magnetic resonance (MR) images (five patients), computed tomographic (CT) scans (three patients) and whole body scintigraphy (two patients) were reviewed and analyzed. Images were evaluated with regard to lesion location, size, margin, muscle or bone involvement and intrinsic imaging characteristics on CT and MRI. The tumors were located in the thigh (three patients), back (two patients) and upper arm (one patient). The tumors ranged in size from 2.3 cm to 7.5 cm (mean, 5.2 cm), were mainly well circumscribed and showed no evidence of calcification prior to treatment. Margins were well defined in four out of the six patients. Four patients had ...
2005-09-01
Energy Technology Data Exchange (ETDEWEB)
In transfusion-dependent {beta}-thalassemia major, increased iron deposition in the pituitary gland has a cytotoxic effect leading mainly to hypogonadotropic hypogonadism. Our purpose was to assess in these patients the height of the pituitary gland and to evaluate whether it represents a marker of pituitary gland function. In 29 patients with {beta}-thalassemia major and 35 age- and gender-matched controls the pituitary gland height was evaluated in a midline sagittal scan using a spin echo T1-weighted (500/20 TR/TE) sequence. In all patients, an extensive endocrine evaluation was performed, including measurements of spontaneous and stimulated levels of gonadotropins, thyroid hormones, growth hormone, insulin-like growth factor, and adrenal hormones. The pituitary gland height was lower in thalassemic patients with hypogonadotropic hypogonadism (n=15) (mean 3.48; SD 0.46) than in the age- and gender-matched controls (mean ...
2001-12-01
Energy Technology Data Exchange (ETDEWEB)
To assess the utility of magnetic resonance (MR) imaging in the study of pediatric patients with clinical suspicion of pituitary disease. We studied 18 patients aged 7 to 18 years.Fifteen had hormonal disturbances, two presented amenorrhea and 1 complained of headache, fever and symptoms of polyuria and polydipsia. All the patients were examined using a Siemens SP 42 1-Tesla MRI scanner. Sagittal and coronal T1-weighted spin-echo images were obtained; in addition T2-weighted spin-echo or fast spin-echo imaging was performed in ten cases and intravenous gadolinium was administered in nine. We found 9 patients with hypothalamic-pituitary dysgenesis, 2 with germinoma, 2 cases of pituitary hemosiderosis in patients with thalassemia, 2 cases of microadenoma, one abscess, one case of idiopathic central diabetes insipidus and one of Langerhans cell histiocytosis. MR enabled us to assess pituitary structural alterations in children ...
2000-07-01
International Nuclear Information System (INIS)
Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glial cell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR ...
2007-02-01
MRI in the diagnosis of non-compacted ventricular Myocardium (NCVM) compared to echocardiography
International Nuclear Information System (INIS)
Purpose: To report the detection of con-compacted ventricular myocardium (NVCM) with MRI compared to echocardiography in 8 patients. Material and methods: Non-compaction of the ventricular myocardium is a congenital disorder characterized by an altered structure of the myocardial wall resulting from an intrauterine arrest in endomyocardial embryogenesis. The morphological findings consist of a prominent meshwork of multiple myocardial trabeculations and deep intertrabecular recesses, communicating with the left ventricular cavity. 8 consecutive patients (mean age 7.3 years) with clinical and echocardiographic signs of NCVM were examined by MRI (1.5 T, Vision, Siemens) in short axis and 2- and 4-chamber views, using T_1-weighted TSE and Cine-GRE in 6 patients and true FISP sequences in 2 patients. MRI and echocardiography were evaluated for visibility, signs of NCVM and involvement of myocardial wall segments. Thickness was ...
2003-09-01
MR findings in cases of suspected impacted fracture of the femoral neck
Energy Technology Data Exchange (ETDEWEB)
Purpose: To evaluate MR imaging of the hip in patients with a clinically suspected impacted fracture of the femoral neck in cases where conventional plain films show negative or equivocal findings. Material and Methods: Twenty-seven such patients were prospectively examined by MR imaging with a 1.0 T unit, within 24 hours of admittance to hospital. A coronal T1-weighted turbo spin-echo sequence (n=27), and a coronal STIR sequence (n=25) or a coronal T2-weighted turbo spin-echo fast saturation sequence (n=2) were used. The evaluations were made by 2 radiologists with experience in musculoskeletal radiology. Results: There were 6 patients with a petrochanteric fracture, 2 without and 4 with slight displacement. Five patients had an impacted fracture of the femoral neck, and 3 had a fracture of the superior pubic bone. Of 2 patients with advanced arthrosis, i had an impacted femoral neck fracture and the other a nondisplaced ...
1997-09-01
Energy Technology Data Exchange (ETDEWEB)
The purpose of this study was to correlate MR imaging findings with pathology in experimental hyperoxia-induced acute lung injury, which has similar pathology to diffuse alveolar damage (DAD). Seventeen Yorkshire pigs were studied. These animals were exposed to more than 80% oxygen for 24, 48, 72, and 96 hours in a sealed cage. The lungs were removed and inflated with air infused through the trachea, and then examined by both MRI and high-resolution CT (HRCT). T1-weighted spin-echo (T1WSE), T2-weighted fast (T2WFSE), and half-Fourier acquisition single-shot turbo spin-echo (HASTE) sequences were performed. Severity in MR findings and signal-to-noise ratios (SNR) on MR images were well correlated with pathological scores. CT values were also correlated well with pathologic scores. Abnormal SNR values were obtained from a pathological score of 5, whereas abnormal CT values were obtained from a pathological score of 15. ...
2001-06-01
Experimental study of lipiodol ultra-fluid. On its signal intensity in MR imaging
Energy Technology Data Exchange (ETDEWEB)
Lipiodol Ultra-Fluid (Lipiodol) is widely applied in the transcatheter arterial embolization (TAE). We studied signal intensity, the T1 relaxation time and the T2 relaxation time of Lipiodol itself using Siemens Magnetom H15-2 T (1.5 Tesla) and Magnetom M10 (1.0 Tesla). Lipiodol showed higher signal intensity than saline solution on the T1-weighted images (short TR, short TE technique in spin echo method). On the T2-weighted images (long TR, long TE technique in spin echo method), Lipiodol showed lower signal intensity than saline solution. The T1 relaxation time of Lipiodol, measured at 1.0 T, was 201 msec and 218 msec at 1.5 T. The T2 relaxation time of Lipiodol, measured at 1.0 T, was 127 msec; and 167 msec at 1.5 T. The signal intensity of Lipiodol at 1.0 T was higher than the intensity at 1.5 T. Shorter T1 relaxation time of Lipiodol at 1.0 T is probably responsible for the higher intensity at 1.0 T. When MRI is ...
1988-11-01
Distinguishing benign notochordal cell tumors from vertebral chordoma
Energy Technology Data Exchange (ETDEWEB)
The objective was to characterize imaging findings of benign notochordal cell tumors (BNCTs). Clinical and imaging data for 9 benign notochordal cell tumors in 7 patients were reviewed retrospectively. Conventional radiographs (n = 9), bone scintigrams (n = 2), computed tomographic images (n = 7), and magnetic resonance images (n = 8) were reviewed. Eight of the 9 lesions were stained with hematoxylin-eosin and microscopically examined. There were 3 male and 4 female patients with an age range of 22 to 55 years (average age, 44 years). Two patients had two lesions at different sites. The lesions involved the cervical spine in 4 patients, the lumbar spine in 2, the sacrum in 2, and the coccyx in 1. The most common symptom was mild pain. The lesions of 2 patients were found incidentally during imaging studies for unrelated conditions. Five patients underwent surgical procedures. One patient died of surgical complications. All other patients have been well without recurrent or progressive ...
2008-04-15
Diagnosis of plasmocytomas using magnetic resonance imaging
International Nuclear Information System (INIS)
Background. In multiple myeloma 5 different infiltration patterns can be differentiated: 1. Normal appearance of bone marrow, 2. focal involvement, 3. homogeneous diffuse infiltration, 4. combined diffuse and focal infiltration, 5. 'salt-and pepper' pattern with inhomogeneous bone marrow with interposition of fat islands. Methods. For the fast and total acquisition of all patterns a combination of a T1-weighted spin echo sequence and a fat suppression technique is superior. The focal involvement is clearly demonstrated as areas of high signal intensity on e.g. STIR images. Diffuse involvement can be quantified objectively by calculation of the percentage of signal intensity increase after contrast material injection. MRI is superior to X-ray in focal and diffuse involvement. With ultrafast sequences a 'screening' of the whole red bone marrow as for myeloma infiltration is possible. Prognosis. In prognosis studies diffuse ...
2000-08-01
Developmental cortical thinning in fetal alcohol spectrum disorders.
Regional cortical thickness was evaluated using CIVET processing of 3D T1-weighted images (i) to compare the variation in cortical thickness between 33 participants with fetal alcohol spectrum disorders (FASD) aged 6-30 years (mean age 12.3 years) versus 33 age/sex/hand-matched controls, and (ii) to examine developmental changes in cortical thickness with age from children to young adults in both groups. Significant cortical thinning was found in the participants with FASD in large areas of the bilateral middle frontal lobe, pre- and post- central areas, lateral and inferior temporal and occipital lobes compared to controls. No significant cortical thickness increases were observed for the FASD group. Cortical thinning with age in a linear model was observed in both groups, but the locations were different for each group. FASD participants showed thinning with age in the left middle frontal, bilateral precentral, bilateral ...
2011-06-17
International Nuclear Information System (INIS)
The purpose of this study is to develop a geometrically accurate imaging protocol at 3 T magnetic resonance imaging (MRI) for stereotactic radiosurgery (SRS) treatment planning. In order to achieve this purpose, a methodology is developed to investigate the geometric accuracy and stability of 3 T MRI for SRS in phantom and patient evaluations. Forty patients were enrolled on a prospective clinical trial. After frame placement prior to SRS, each patient underwent 3 T MRI after 1.5 T MRI and CT. MR imaging protocols included a T1-weighted gradient echo sequence and a T2-weighted spin echo sequence. Phantom imaging was performed on 3 T prior to patient imaging using the same set-up and imaging protocols. Geometric accuracy in patients and phantoms yielded comparable results for external fiducial reference deviations and internal landmarks between 3 T and 1.5 T MRI (mean ?0.6 mm; standard deviation ?0.3 mm). Mean stereotactic ...
2010-11-21
Energy Technology Data Exchange (ETDEWEB)
To assess whether ring enhancements of liver metastases on Mn-DPDP enhanced, early MR images were well visualized on delayed images, as compared with those of hepatocellular carcinomas (HCC), and to investigate the detection accuracy and conspicuity of each tumor. Twenty patients with liver metastases and 15 with HCC were studied by Mn-DPDP enhanced, T1-weighted MR images. Peripheral ring enhancement and conspicuity were investigated. Differences in detection accuracy and frequency of ring enhancement in liver metastases and HCC were assessed. In liver metastases (n= 69), 44 cases (63.8%) without ring enhancement and 25 (36.2%) with were noted on early images. Sixteen cases (23.2%) without ring enhancement, 38 (55.1%) with ring enhancement similar to the early images, and 15 (21.7%) with prominent ring enhancement were noted on delayed images. In HCC (n=37), 36 cases (97.3%) without ring enhancement and 1 case (2.7%) with ...
2004-09-01
The Preliminary GAMMA Code Thermal hydraulic Analysis for the Steady State of HTR-10 Initial Core
Energy Technology Data Exchange (ETDEWEB)
This report describes the preliminary thermalhydraulic analysis of HTR-10 steady state full power initial core to provide a benchmark calculation of VHTGR(Very High-Temperature Gas-Cooled Reactors) safety analysis code of GAMMA(GAs Multicomponent Mixture Analysis). The input data of GAMMA code are produced for the models of fluid block, wall block, radiation heat transfer and each component material properties in HTR-10 reactor. The temperature and flow distributions of HTR-10 steady state 10 MW{sub th} full power initial core are calculated by GAMMA code with boundary conditions of total reactor inlet flow rate of 4.32 kg/s, inlet temperature of 250 .deg. C, inlet pressure of 3 MPa, outlet pressure of 2.992 MPa and the fixed temperature at RCCS water cooling tube of 50 .deg C. The calculation results are compared with the measured solid material temperatures at 22 fixed instrumentation positions in ...
2006-07-15
High-flux source of fusion neutrons for material and component testing
Energy Technology Data Exchange (ETDEWEB)
The inner part of a fusion reactor will have to operate at very high neutron loads. In steady-state reactors the minimum fluence before the scheduled replacement of the reactor core should be at least l0-15 Mw.yr/m2. A more frequent replacement of the core is hardly compatible with economic constraints. A most recent summary of the discussions of these issues is presented in Ref. [l]. If and when times come to build a commercial fusion reactor, the availability of information on the behavior of materials and components at such fluences will become mandatory for making a final decision. This makes it necessary an early development and construction of a neutron source for fusion material and component testing. In this paper, we present information on one very attractive concept of such a source: a source based on a so called Gas Dynamic Trap. This neutron source was proposed in the mid 1980s (Ref. [2]; see also a survey [3] with discussion of ...
1999-01-07
Single photon emission computed tomography and its neurological application
Energy Technology Data Exchange (ETDEWEB)
A review is made of the various brain imaging agents utilised in the post few years with their own characters and respective advantages: cerebral blood volume tracers, non diffusible tracers, diffusible tracers among which gases and lipophilic agents. Our results with IAMP and SPECT are presented in two different clinical application fields: normal pressure hydrocephalus and cerebral ischemia.
1984-12-01
Single photon emission computed tomography and its neurological application
International Nuclear Information System (INIS)
A review is made of the various brain imaging agents utilised in the post few years with their own characters and respective advantages: cerebral blood volume tracers, non diffusible tracers, diffusible tracers among which gases and lipophilic agents. Our results with IAMP and SPECT are presented in two different clinical application fields: normal pressure hydrocephalus and cerebral ischemia.
CT scan findings in cerebral paragonimiasis
International Nuclear Information System (INIS)
Computed tomography was performed on 5 patients with chronic cerebral paragonimiasis. CT showed solitary or multiple, amorphous, round, or oval calcifications, and ventricular enlargement in all 5 cases. A large low-density area is also found in 4 of the 5 cases. These CT findings are compatible with previously reported findings of simple X-ray films of the skull, pneumoencephalography, and pathological studies. (author).
1982-01-01
The interaction of accretion disks with the magnetospheres of young stars can produce X-winds and funnel flows. With the assumption of axial symmetry and steady state flow, the problem can be formulated in terms of quantities that are conserved along streamlines, such as the Bernoulli integral (BI), plus a partial differential equation (PDE), called the Grad-Shafranov equation (GSE), that governs the distribution of streamlines in the meridional plane. The GSE plus BI yields a PDE of mixed type, elliptic before critical surfaces where the flow speed equals certain characteristic wave speeds are crossed and hyperbolic afterward. The computational difficulties are exacerbated by the locations of the critical surfaces not being known in advance. To overcome these obstacles, we consider a variational principle by which the GSE can be attacked by extremizing an action integral, with all other conserved quantities of the problem explicitly included ...
2007-01-01
Well Test Analysis in Naturally Fissured, Geothermal Reservoirs with Fracture Skin
Mineral deposition or alteration is commonly found at fracture-block interfaces is fissured, geothermal reservoirs. In response to pressure reduction in the fissures such mineralization, if less permeable than the matrix rock, will retard the flow of fluid from the blocks to the fissures and is termed fracture skin in this paper. The problem of fluid flow to a production well in a double-porosity reservoir with fracture skin was analyzed theoretically. One of the findings of the analysis was that fully transient block-to-fissure flow can be approximated by pseudo-steady state flow if fracture skin permeability is sufficiently low. Type curves generated by numerical inversion of Laplace transform solutions are used to cooroborate the results of a finite-difference model of steam transport to a well in a naturally fissured, geothermal reservoir with fracture skin.
1983-12-15
International Nuclear Information System (INIS)
In recent years, there has been increased emphasis on techniques to enhance two-phase flow heat transfer. The resulting increase in the use of heat transfer augmentation and the engineering importance of the subject presents this investigation in order to study the effect of different heater surface configurations on two-phase flow instabilities. The authors present the results of an experimental and theoretical study, summarized as: instabilities are not affected by small changes in heat transfer; nucleate boiling increases system unstability; amplitude of the oscillations increases as the axial temperature gradient over the heater increases; for the same type heater surfaces system stability increases with decreasing equivalent diameter; period of the oscillations depend on the heater surfaces; and linearized analysis and steady-state data can be used to determine the oscillation thresholds.
1985-10-01
Transient testing of FFTF fuel pins in TREAT
International Nuclear Information System (INIS)
A series of six transient tests was performed on FFTF irradiated fuel pins to demonstrate their transient performance capability. The tests were performed in the TREAT reactor using sodium loops and instrumented test trains. The TEMECH computer code was used to design overpower transients which would simulate FFTF fuel pin thermal conditions during slow and fast unprotected transients. Some tests were run to substantial overpower levels but terminated prior to fuel pin failure, while other tests were intentionally extended to fuel failure to establish failure thresholds and characteristics. Post-test examination data provided significant cladding strain and fuel melting information used for performance code calibration and validation. These data showed that cladding damage caused by fuel melting is related to the steady state condition of the fuel.
1986-09-07
Transient simulation of a catalytic converter for a dual fuel engine
Energy Technology Data Exchange (ETDEWEB)
A catalytic converter of a ceramic monolith honeycomb substrate, coated with a washcoat of catalyst and attached to a natural gas/diesel dual fuel engine was simulated and studied experimentally. The paper describes the application of one-dimensional finite element model for the transient and steady state operation. Laminar flow was approximated using a dispersed plug flow model, and chemical kinetics were simulated using LHHW (Langmuir/ Hinshelwood/ Hougan/ Watson) type expressions. Simulation results were compared with experimental results for heating and cooling cycles which resulted from speed and load changes on the engine. The comparison showed a maximum difference between the two sets of emission levels of about 10 per cent, showing that the one-dimensional model is acceptable model for this dual fuel engine converter combination. 50 refs., 3 tabs., 13 figs.
2000-06-01
Thermal-hydraulic analysis following a safety flapper valve's fault for a pool-type research reactor
International Nuclear Information System (INIS)
One of the characteristic safety features of a pool type research reactor is a safety flapper valve. The valve enables natural convection cooling mechanism in one of the following events. (a) Opening flapper valve promote decay heat removal following reactor's shutdown. (b) Also the valve is gravity driven. There is a possibility that the valve fails to open when it is required to do so. In the present paper the cooling characteristics of the core are analyzed for this event. A steady state study was performed for 5 MW power and 18 FE following a reactor shutdown. It is shown that enough margin exists to assure adequate reactor core cooling should the safety flapper valve fails to open. (authors)
Thermal modeling of solar central receiver cavities
Energy Technology Data Exchange (ETDEWEB)
Results are presented from a numerical model of the steady-state energy transfer in molten-salt-in-tube solar cavity receivers that includes convective energy transfer at a local (spatially resolved) level. Molten salt energy absorption and gray radiative transfer between all cavity surfaces are also included. This model is applied to the Molten Salt Subsystem Component Test Experiment (MSS/CTE) cavity receiver. Results for this receiver indicate the global (entire cavity) receiver thermal efficiency is invariant within a few percent to most parameters investigated, although front surface temperatures of the nonabsorbing walls vary considerably, and are particularly sensitive to the type of convective submodel used. Absorption efficiencies indicate the effects of the cavity enclosure environment. For all conditions investigated, tube inner wall temperatures remain under 855 K, ensuring that the salt remains chemically stable.
1989-05-01
Thermal model and thermodynamic performance of molten salt cavity receiver
British Library Electronic Table of Contents (United Kingdom)
The design of a global steady-state thermal model of a 100kWt molten salt cavity receiver was developed as part of the key project of the Ministry of Science and Technology of People's Republic of China (MOST). In the design process, the following factors were analyzed: receiver area, heat loss (convective, emissive, reflective and conductive), number of tubes in the receiver panel, tube diameter and receiver surface temperature. The model was also used to calculate the receiver performance of the Sandia National Laboratories' molten salt electric experiment (MSEE). In addition, the thermal performance of the designed molten salt cavity receiver is presented for a fixed outlet flow rate and a fixed output temperature.
2010-01-01
The thermochromic properties of La{sub 1-x}Sr{sub x}MnO{sub 3} compounds
Energy Technology Data Exchange (ETDEWEB)
La{sub 1-x}Sr{sub x}MnO{sub 3} (LSMO) compounds (0.175{<=}x{<=}0.30) were prepared by conventional solid-state reaction method. Temperature dependence of the total hemispherical emittance ({epsilon}{sub H}) of the compounds from 173 to 373 K was measured on a calorimetric emissometer (CE) which was constructed based on the steady-state calorimetric method. The compounds show thermochromic properties and {epsilon}{sub H}'s have low value at low temperature and have high value at high temperature, because the compounds are dominated by metallic phase and insulator phase, respectively. We use the phase separation model to interpret the temperature dependence of {epsilon}{sub H}. (author)
2008-10-15
International Nuclear Information System (INIS)
The thermal conductivity of liquid CHCl3, C6H6, and CCl4 is measured by a steady-state method under saturated vapor pressure in the temperature regions corresponding to pre-crystallization temperatures. The experimental results obtained are used to investigate the isobaric thermal conductivity jump ? ?p at the crystal-liquid phase transition in CHCl3, C6H6, and CCl4. The contributions of the phonon-phonon and phonon-rotational interaction to the total thermal resistance in solid and liquid state are specified using a modified method of reduced coordinates. The decrease in the thermal conductivity at the crystal-liquid phase transition, ? ?p, is explained by a combined effect of variations in positional distribution of molecules and in the form of rotational molecular motion.
2009-04-01
The thermal conductivity of liquid CHCl3, C6H6, and CCl4 is measured by a steady-state method under saturated vapor pressure in the temperature regions corresponding to pre-crystallization temperatures. The experimental results obtained are used to investigate the isobaric thermal conductivity jump ??p at the crystal-liquid phase transition in CHCl3, C6H6, and CCl4. The contributions of the phonon-phonon and phonon-rotational interaction to the total thermal resistance in solid and liquid state are specified using a modified method of reduced coordinates. The decrease in the thermal conductivity at the crystal-liquid phase transition, ??p, is explained by a combined effect of variations in positional distribution of molecules and in the form of rotational molecular motion.
2009-04-01
The status of the alpha-project
International Nuclear Information System (INIS)
A review of the ALPHA project is presented, including a summary of progress and current status. The project comprises the experimental and analytical investigation of the long-term decay heat removal phenomena from the containment of the next generation of ''passive'' Advanced Light Water Reactors. The effects of aerosols that may result from hypothetical severe accidents are also considered. The construction of the major ALPHA experimental facilities, PANDA, LINX-2 and AIDA, has been completed. First steady-state tests have been performed on PANDA. The other facilities are now in their commissioning phases. Scaling studies have guided the design of the experimental facilities. Several small-scale experimental and studies have already produced valuable results which can be used to direct the experimental work, as well as the design of the passive ALWRs. (author). 23 refs, 6 figs.
1996-04-01
The role of natural circulation in the FFTF [Fast Flux Test Facility] passive safety tests
International Nuclear Information System (INIS)
A series of tests were completed at the Fast Flux Test Facility to demonstrate the passive safety characteristics of liquid metal reactors with natural circulation flow. The first test consisted of transition from forced to natural circulation flow at an initial decay power of 0.3%. The second test represented an unprotected loss-of-flow transient to natural circulation from 50% power with the control rods prevented from scramming into the core. The third test was a steady-state, natural circulation condition with core fission powers up ato about 2.3%. Core sodium data and results of single and multi-channel computer models confirmed the reliability and effectiveness of natural circulation flow for liquid metal reactor safety.
1987-12-13
International Nuclear Information System (INIS)
The PANDA test facility at PSI in Switzerland is used to study the long-term Simplified Boiling Water Reactor (SBWRT) Passive Containment Cooling System (PCCS) performance. The PANDA tests demonstrate performance on a larger scale than previous tests and examine the effects of any non-uniform spatial distributions of steam and noncondensables in the system. The PANDA facility is in 1:1 vertical scale, and 1:25 'system' scale (volume, power, etc.). Steady-state PCCS condenser performance tests and extensive facility characterization tests have already been conducted. A series of transient system behavior tests have been completed by end of 1995. Results from the first three transient tests (M3 series) are reviewed. The first PANDA tests exhibited reproducibility, and indicated that the SBWR containment is likely to be favorably responsive and highly robust to changes in the thermal transport patterns. (author) 6 figs., 11 refs.
The PANDA tests for SBWR certification
International Nuclear Information System (INIS)
The ALPHA project is centered around the experimental and analytical investigation of the long-term decay heat removal from the containments of the next generation of open-quotes passiveclose quotes ALWRs. The project includes integral system tests in the large-scale (1:25 in volume) PANDA facility as well as several other series of tests and supporting analytical work. The first series of experiments to be conducted in PANDA have become a required experimental element in the certification process for the General Electric Simplified Boiling Water Reactor (SBWR). The PANDA general experimental philosophy, facility design, scaling, and instrumentation are described. Steady-state PCCS condenser performance tests and extensive facility characterization tests were already conducted. The transient system behavior tests are underway; preliminary results from the first transient test M3 are reviewed.
1996-03-01
The PANDA facility and first test results
International Nuclear Information System (INIS)
The PANDA test facility at the Paul Scherrer Institute is used to study the long-term performance of the Simplified Boiling Water Reactor's passive containment cooling system. The PANDA tests demonstrate performance on a larger scale than previous tests and examine the effects of any non-uniform spatial distributions of steam and non-condensable gases in the system. The facility is in 1:1 vertical scale and 1:25 scale for volume, power etc. Extensive facility characterization tests and steady-state passive containment condenser performance tests are presented. The results of the base case test of a series of transient system behaviour tests are reviewed. The first PANDA tests exhibited reproducibility, and indicated that the Simplified Boiling Water Reactor's containment is likely to be favorably responsive and highly robust to changes in the thermal transport patterns. (orig.).
British Library Electronic Table of Contents (United Kingdom)
This paper describes the modeling of horizontal steam generator with the TRACE code and calculation results of a loss-of-feedwater (LOF-10) experiment at the PACTEL facility. Parallel Channel Test Loop (PACTEL) is an integral test facility for a VVER-440 type nuclear reactor. The main objectives were to prepare a simulation model for its horizontal steam generator with the TRACE thermal hydraulic code and assess different modeling options of the code. PACTEL experiment LOF-10 was chosen for this assessment. The calculation results showed that TRACE is capable in simulating horizontal steam generator behavior both in steady state and during loss-of-feedwater transient. The phenomenon of heat transfer from primary to secondary side, steam superheating and flow reversal in the lowest heat exc...
2010-01-01
State of the art simulations of magnicon
International Nuclear Information System (INIS)
The magnicon is a highly attractive candidate to be the RF source for a future multi-Tev linear collider. Physical models and computer codes have been developed which can provide start-to-end self-consistent simulations of a magnicon, including precise simulations of the high-convergence electron gun, RF-system, magnetic system, and beam collector. The 3-D beam dynamics simulations include realistic fields, finite beam size and transverse space charge effects. The codes allow one to provide steady-state simulations of the entire tube, so as to evaluate transient process of magnicon excitation, parasitic mode self-excitation, stability analysis, and tolerance analysis. The results of the simulations are found to be in good agreement with magnicon experiments. A brief description of the physical models and simulation codes employed will be given.
2002-12-12
Spontaneously generated atomic entanglement in free space: reinforced by incoherent pumping
We study spontaneously generated entanglement (SGE) between two identical multilevel atoms in free space via vacuum-induced radiative coupling. We show that the SGE in two-atom systems may initially increase with time but eventually vanishes in the time scale determined by the excited state lifetime and radiative coupling strength between the two atoms. We demonstrate that a steady-state SGE can be established by incoherently pumping the excited states of the two-atom system. We have shown that an appropriate rate of incoherent pump can help producing optimal SGE. The multilevel systems offer us more chanel to establish entanglement. The system under consideration could be realized in a tight trap or atoms/ions doped in a solid substrate.
2009-01-01
Solubility of AmOHCO{sub 3} in aqueous solution under atmospheric conditions
Energy Technology Data Exchange (ETDEWEB)
Modeling calculations on the solubility of americium have indicated that basic americium carbonate, and not americium trihydroxide, is the solubility-controlling solid in the pH range from 6 to 10 under the influence of atmospheric CO{sub 2}. The solubility of crystalline {sup 243}AmOHCO{sup 3} has been investigated in batch experiments in near-neutral and basic solutions as a function of dissolution time in 0.1 M NaClO{sup 4} at room temperature under oxic conditions. After the solutions reached steady-state conditions, the influence of dissolved solids on the americium concentration in the supernatant solution was studied by utilizing several experimental methods to separate the solution phase from the solid. The solids were characterized by X-ray powder diffraction analysis.
1987-12-01
Solar thermophotovoltaic (STPV) system with thermal energy storage
Energy Technology Data Exchange (ETDEWEB)
A solar thermophotovoltaic (STPV) system has both terrestrial and space applications because thermal energy storage can be utilized. Excellent properties (heat of fusion=1800 j/gm and melting temperature=1680 K) make silicon the ideal thermal storage material for an STPV system. Using a one dimensional model with tapering of the silicon storage material, it was found that several hours of running time with modest lengths ({approximately}15 cm) of silicon are possible. Calculated steady-state efficiencies for an STPV system using an Er-YAG selective emitter and ideal photovoltaic (PV) cell model are in the range of 15{percent}{endash}17{percent}. Increasing the taper of the storage material improves both efficiency and power output. {copyright} {ital 1996 American Institute of Physics.}
1996-02-01
Simulation of the filtration mechanism of hyaluronic acid in total knee prosthesis
Energy Technology Data Exchange (ETDEWEB)
Polyethylene (UHMWPE) wear in current knee prosthesis causes prosthesis loosening after no more than 15 years. In this work, a steady state one-dimensional lubrication model with non- Newtonian fluid, porous elastic layer on tibial component, ultra-filtration mechanism of fluid and some features of the surface roughness is studied through a numerical technique based on the Finite Element Method. The results show that the UHMWPE stiffness makes difficult the lubrication mechanism of the artificial joint and promotes abrasive and fatigue wear. Nevertheless, the use of compliant porous materials on the tibial component could reduce friction and wear. Moreover, the ultra-filtration mechanism promotes efficiency on the joint.
2007-11-15
Satisfying story of how it all began
Energy Technology Data Exchange (ETDEWEB)
{sup N}ow this 'Big Bang' idea seemed to me to be unsatisfactory...for it is an irrational process that cannot be described in scientific terms.' With this rather derisory remark (or at least so intended) in a 1950 radio broadcast, Fred Hoyle named the theory that rivalled his steady-state theory. The Big Bang has subsequently become the dominant paradigm in attempts to understand our universe. It is also one of the dominant ways in which popular-science writing seeks to persuade people to part with their cash. Simon Singh has rapidly made a name for himself as one of the leading popularizers of science, with his previous books Fermat's Last Theorem and The Code Book bringing accessible science to a wide audience . Big Bang brings him to a much busier marketplace, where he must compete both with other science writers and with working scientists. (U.K.)
2004-12-01
Resonantlike phenomenon in short-pulse free-electron-laser oscillators with modulated desynchronism
International Nuclear Information System (INIS)
Recently a new method of controlling the pulse length of a short-pulse free-electron laser (FEL) has been developed. By modulating the synchronism between the optical and electron pulses in the FEL cavity, it was found that the output power and the micropulse length of the FEL beam oscillates at the modulation frequency. In this paper, we study theoretically the behavior of the micropulse length, both in the high loss (steady state) regime and the low loss (limit cycle) regime, when a modulated desynchronism is applied. In order to do this, we analyze the dynamics of a short-pulse FEL oscillator. The modulation frequency value plays an important role in the dynamics. We find that there is a resonantlike phenomenon between the externally applied desynchronism modulation and the limit cycle oscillation without modulation of a free-electron laser.
2002-01-01
Reflux boiling heat removal in a scaled TMI-2 system test facility
International Nuclear Information System (INIS)
An investigation of decay heat removal by the reflux boiling process was performed on a 1/18 linear-scaled test facility simulating the Three Mile Island (TMI-2) primary system. The objective was to clarify reflux boiling phenomena and core cooling effectiveness. Principal test variables included: core power, primary system water and gas inventories, and steam generator secondary-side coolant flow rate. Of 49 tests conducted, 43 achieved a steady-state heat rejection mode within 3 hours. Subsequent analyses identified two distinct reflux boiling modes. Based upon our current understanding, reflux boiling appears to be an effective process for removing decay heat in a broad range of the conditions investigated for a plant of the TMI configuration.
1980-06-01
British Library Electronic Table of Contents (United Kingdom)
The objective of this study is to develop an artificial neural network (ANN) model to predict the thermal conductivity of ethylene glycol-water solutions based on experimentally measured variables. The thermal conductivity of solutions at different concentrations and various temperatures was measured using the cylindrical cell method that physical properties of the solution are being determined fills the annular space between two concentric cylinders. During the experiment, heat flows in the radial direction outwards through the test liquid filled in the annual gap to cooling water. In the steady state, conduction inside the cell was described by the Fourier equation in cylindrical coordinates, with boundary conditions corresponding to heat transfer between the solution and cooling water. ...
2009-01-01
International Nuclear Information System (INIS)
Ppercase(femaxi-iv) is a computer code for the analysis of thermal and mechanical behavior of light water reactor fuel rods during steady-state and transient conditions. The main purpose of ppercase(femaxi-iv) is to calculate the stress and strain distributions in the fuel and cladding due to the pellet-cladding mechanical interaction, and the fission gas release rate during operations, especially power transients. The capability of ppercase(femaxi-iv) was extensively tested with a number of experimental results obtained in some international fuel irradiation programs. This paper provides a general description of the various models involved in ppercase(femaxi-iv) and some results of applications on the experimental data. ((orig.)).
1994-01-01
Post-CHF heat transfer with water and refrigerants
Energy Technology Data Exchange (ETDEWEB)
Heat transfer experiments were performed in the post-CHF two-phase flow regime in a vertical tube. The tube inside diameter was 7.75 mm, and the boiling fluid was R-113. The experiments were performed at steady state by means of liquid heating of the test tube. Wall superheats were maintained below 70 C for heat exchanger/steam generator application. The mass flux range of the data was 379-816 kg m{sup -2} s{sup -1}. The use of R-113 significantly extended the property range of the existing low wall-superheat data base. Experimental data are presented in tabular as well as graphical form, and the results were used with low wall-superheat data from other fluids to add generality to a predictive heat transfer correlation. (orig.)
1996-06-01
British Library Electronic Table of Contents (United Kingdom)
The photocytotoxic effect of hypericin (Hyp) targeted by two different delivery techniques, namely, liposomes and anti-hepatocyte specific antigen (anti-HSA) was investigated. Optical absorption and steady-state fluorescence were used to analyze the conjugation of Hyp with anti-HSA model and to evaluate the encapsulation capacity and drug release in a liposome model. Particle size and thermal analysis of the prepared liposomes were performed using laser-light scattering and differential scanning calorimetry (DSC), respectively. Viability study of HepG2 cells exposed to Hyp in the two delivery systems, in the dark and following visible light irradiation, was performed in comparison to free Hyp. The intracellular uptake and localization of Hyp in HepG2 cells were analyzed by means of spectro...
2010-01-01
British Library Electronic Table of Contents (United Kingdom)
This paper analyzes the F-policy M/M/1/K queueing system with working vacation and an exponential startup time. The F-policy deals with the issue of controlling arrivals to a queueing system, and the server requires a startup time before allowing customers to enter the system. For the queueing systems with working vacation, the server can still provide service to customers rather than completely stop the service during a vacation period. The matrix-analytic method is applied to develop the steady-state probabilities, and then obtain several system characteristics. We construct the expected cost function and formulate an optimization problem to find the minimum cost. The direct search method and Quasi-Newton method are implemented to determine the optimal system capacity K, the optimal thre...
2010-01-01
British Library Electronic Table of Contents (United Kingdom)
For optimal performances, proton exchange membrane fuel cells require fine water and thermal management. Accurate modelling of the physical phenomena occurring in the fuel cell is a key issue to improve fuel cell technology. Here, an analytic steady state diphasic 2D model of heat and mass transfer is presented. Through this model, the aim of this work is to study the influence of local events on the global performances of a fuel cell. A part of the complete model is a microscopic representation of the coupling between water transport and charge transfers in the electrodes. The thickness of the liquid layer around the reactive agglomerates is deduced from the saturation. The evolution of the quantity of water within the catalyst layer is monitored and its influence on the global performanc...
2010-01-01
Numerical evaluation of effective unsaturated hydraulic properties for fractured rocks
Energy Technology Data Exchange (ETDEWEB)
To represent a heterogeneous unsaturated fractured rock by its homogeneous equivalent, Monte Carlo simulations are used to obtain upscaled (effective) flow properties. In this study, we present a numerical procedure for upscaling the van Genuchten parameters of unsaturated fractured rocks by conducting Monte Carlo simulations of the unsaturated flow in a domain under gravity-dominated regime. The simulation domain can be chosen as the scale of block size in the field-scale modeling. The effective conductivity is computed from the steady-state flux at the lower boundary and plotted as a function of the averaging pressure head or saturation over the domain. The scatter plot is then fitted using van Genuchten model and three parameters, i.e., the saturated conductivity K{sub s}, the air-entry parameter {alpha}, the pore-size distribution parameter n, corresponding to this model are considered as the effective K{sub s}, effective {alpha}, and effective n, respectively.
2009-01-01
British Library Electronic Table of Contents (United Kingdom)
The effects of thermal radiation and viscous dissipation on magneto-hydrodynamic (MHD) unsteady free-convection flow over a semi-infinite vertical porous plate are analysed. The fluid considered is non-gray (absorption coefficient dependent on wave length). The Network Simulation Method is used to solve the boundary-layer equations based on the finite-difference formulation; only discretization of the spatial co-ordinates is necessary, while time remains as a real continuous variable. This method provides a solution for both transient and steady-state problems at the same time, and programming does not require manipulation of the sophisticated mathematical software that is inherent in other numerical methods. The velocity, temperature, local skin-friction and local Nusselt number are studi...
2007-01-01
Multi-Dimensional Analysis for Sodium Hot Pool using MARS-LMR in Steady State
International Nuclear Information System (INIS)
DBEs (Design Basis Event) of KALIMER-600 (Korea Advanced Liquid Metal Reactor) were analyzed in one dimension by KAERI (Korea Atomic Energy Research Institute). KALIMER-600 is the pool type SFR (Sodium cooled Fast Reactor), thereby the sodium of primary system is prohibited movement to out of a reactor vessel. There are many contacting and including compositions in the sodium hot pool, such as IHX (Intermediate Heat eXchanger), DHX (Decay Heat eXchanger), Pump, UIS (Upper Internal Structure), and core. Moreover, the complex phenomena are occurred in sodium hot pool during steady and transient states. Therefore, the one dimensional analysis is modified to the multi-dimensional analysis through modification of sodium hot pool from one to three dimensions
2010-10-01
Energy Technology Data Exchange (ETDEWEB)
A kinetic model based on the Mars-van Krevelen mechanism that allows to describe the microkinetics of the heterogeneously catalysed partial oxidation of {alpha}, {beta}-unsaturated aldehydes is presented. This conversion is represented by a network, composed of the oxidation of the {alpha}, {beta}-unsaturated aldehyde towards the {alpha}, {beta}-unsaturated carboxylic acid and the consecutive oxidation of the acid as well as the parallel reaction of the aldehyde to products of deeper oxidation. The reaction steps of aldehyde respectively acid oxidation and catalyst reoxidation have been investigated separately in transient experiments. The combination of steady state and transient experiments has led to an improved understanding of the interaction of the catalyst with the aldehyde and the carboxylic acids as well as to a support of the kinetic model assumptions. (orig.)
1998-12-31
Modeling protein synthesis from a physicist's perspective: a toy model
Proteins are polymers of amino acids. These macromolecules are synthesized by intracellular machines called {\\it ribosome}. Although, traditionally, the experimental investigation of protein synthesis has been an active area of research in molecular cell biology, important quantitative models of this phenomenon have been reported mostly in the research journals devoted to statistical physics and related interdisciplinary topics. From the perspective of a physicist, protein synthesis is a phenomenon of {\\it classical transport of interacting ribosomes on a messenger RNA (mRNA) template} that dictates the sequence of the amino acids on the protein. Here we bring this frontier area of contemporary research into the classroom by appropriate simplification of the models and methods. In particular, we develope a simple toy model and analyze it by some elementary techniques of non-equilibrium statistical mechanics to predict the average rate of protein synthesis and their spatial ...
2007-01-01
Modeling of sputtering and redeposition in focused-ion-beam trench milling
Energy Technology Data Exchange (ETDEWEB)
Modeling is performed for focused-ion-beam (FIB) sputtering and redeposition on trench sidewalls in a steady state approximation. Calculations are carried out to demonstrate the sputtered surface profile under known parameters such as sputtering yield as a function of ion incident angle, the FIB current density profile, and the FIB scan speed. It is found that a steplike slope with a gradient angle of {theta}{sub 0} is formed at the FIB bombarding position. Furthermore, the redeposition flux on the sidewalls is calculated as a function of {theta}{sub 0} for the FIB trench milling assuming the cosine law for the angular distribution of the sputtered atom. The redeposition will be more accurately predictable and controllable when more information about these assumptions is obtained.
1991-11-01
Modeling of sputtering and redeposition in focused-ion-beam trench milling
International Nuclear Information System (INIS)
Modeling is performed for focused-ion-beam (FIB) sputtering and redeposition on trench sidewalls in a steady state approximation. Calculations are carried out to demonstrate the sputtered surface profile under known parameters such as sputtering yield as a function of ion incident angle, the FIB current density profile, and the FIB scan speed. It is found that a steplike slope with a gradient angle of #theta#_0 is formed at the FIB bombarding position. Furthermore, the redeposition flux on the sidewalls is calculated as a function of #theta#_0 for the FIB trench milling assuming the cosine law for the angular distribution of the sputtered atom. The redeposition will be more accurately predictable and controllable when more information about these assumptions is obtained.
British Library Electronic Table of Contents (United Kingdom)
Lebers hereditary optic neuropathy (LHON), the most frequent mitochondrial disorder, is mostly due to three mitochondrial DNA (mtDNA) mutations in respiratory chain complex I subunit genes: 3460/ND1, 11778/ND4 and 14484/ND6. Despite considerable clinical evidences, a genetic modifying role of the mtDNA haplogroup background in the clinical expression of LHON remains experimentally unproven. We investigated the effect of mtDNA haplogroups on the assembly of oxidative phosphorylation (OXPHOS) complexes in transmitochondrial hybrids (cybrids) harboring the three common LHON mutations. The steady-state levels of respiratory chain complexes appeared normal in mutant cybrids. However, an accumulation of low molecular weight subcomplexes suggested a complex I assembly/stability defect, which was ...
2008-01-01
Measuring air movement locally in the combustion chambers of a direct-injection diesel engine
Energy Technology Data Exchange (ETDEWEB)
Measurements of smoke and NO emissions from a direct-injection diesel engine have shown that they are indeed influenced by inlet port design, even though the swirl numbers for the ports may be identical. The swirl numbers of the three ports used (tangential port, helical port and helical port with masked valve) were measured on a steady-state test rig using a paddle-wheel anemometer and impulse swirl meter. Flow measurements were carried out under motoring conditions with a constant-temperature, hot-wire anemometer. Is was possible to find a correlation between flow data and exhaust data as far as the in-cylinder air motion over a certain time interval is concerned.
1983-02-01
Energy Technology Data Exchange (ETDEWEB)
The light gain due to S/sub 2/ molecules in a supersonically cooled gas mixture is calculated. The S/sub 2/ molecules formed due to the recombination of the sulfur atoms, and the combustion gas mixture was preheated in a precombustion chamber. Optimal gas flow and nozzle parameters are found which correspond to the highest possible light gain using Cs/sub 2/-Ar and S/sub 2/-Ar gas mixtures. The steady state gas flow in the nozzle was calculated, taking into account the chemical reactions in the one-dimensional approximation. It is shown that the maximum gain values vary in the 0.0001-0.002 range for gas pressures in the precombustion chamber in the range 10-100 atm. The optimal initial relative concentration of Cs/sub 2/ molecules and S/sub 2/ molecules are given. 32 references.
1985-08-01
Jamming in granular hopper flow.
Energy Technology Data Exchange (ETDEWEB)
Large-scale three dimensional molecular dynamics simulations of hopper flow are presented. The flow rate of the system is controlled by the width of the aperture at the bottom. As the steady-state flow rate is reduced, the force distribution P(f) changes only slightly, while there is a large change in the impulse distribution P(i). In both cases, the distributions show an increase in small forces or impulses as the systems approach jamming, the opposite of that seen in previous Lennard-Jones simulations. This occurs dynamically as well for a hopper that transitions from a flowing to a jammed state over time. The final jammed P(f) is quite distinct from a poured packing P(f) in the same geometry. The change in P(i) is a much stronger indicator of the approach to jamming. The formation of a peak or plateau in P(f) at the average force is not a general feature of the approach to jamming.
2005-06-01
Investigation of the steady state and transient operating behaviour of a 20 kW pressure electrolyser
Energy Technology Data Exchange (ETDEWEB)
The present paper describes the investigation of the static and dynamic behaviour of an 20 kW pressure electrolyser. The suitability for a coupled operating regime with a wind power plant has been investigated. At first the static behaviour has been analysed. The share of oxygen in hydrogen gas is lower than 0.5 Vol%. But reaching the temperature limit of 80 deg C leads to a switch off of the electrolyser, accompanied by an increase of the oxygen share in hydrogen gas up to 1.3 Vol%. Therefore, an improvement of the cooling system is necessary. Secondly, the electrolyser was excited by different step signals for load changing and finally, the electrolyser has been controlled by the power output signal of the windmill. The investigation shows that the development of a direct coupled wind-hydrogen system will be only a small step. 3 refs.
1998-07-01
Interfacial area transport equation: model development and benchmark experiments
Energy Technology Data Exchange (ETDEWEB)
The interfacial area transport equation dynamically models two-phase flow regime transitions and predicts continuous changes of the interfacial area concentration along the flow field. It replaces the flow regime-dependent correlations for the interfacial area concentration in thermal-hydraulic system analysis. In the present study, detailed formulation of the interfacial area transport equation is presented along with its evaluation results based on the detailed benchmark experiments. In view of model evaluation, the equation is simplified into one-dimensional steady state one-group interfacial area transport equation. The prediction made by model agrees well with the experimental data obtained in round pipes of various diameters. The framework for the two-group transport equation and the necessary constitutive relations are also presented in view of bubble transport of various sizes and shapes. (author)
2002-07-01
Energy Technology Data Exchange (ETDEWEB)
The effect of varying pD(11-13,7) on the reaction of hydrogen with (Co/sup 11/(CN)/sub 5/)/sup 3/- in deuterium oxide has been studied by using infrared spectroscopy to determine the ratio of (Co/sup 111/(CN)/sub 5/X)/sup 3/- (X=H,D) in the solids precipitated from the steady state under hydrogen. The results show that the uptake of hydrogen does not liberate a free proton and that the rate of (Co/sup 111/(CN)/sub 5/H)/sup 3/- -D/sub 2/,0 exchange increases with pD but becomes pD independent at pD 7 greater than 13,5.
1982-01-01
Heterogeneity of the radiosensitivity and origins of tissue macrophage colony-forming cells
Energy Technology Data Exchange (ETDEWEB)
Previous studies suggest that the radiosensitivity and origin of tissue macrophage precursors differ from those of hemopoietic macrophage colony-forming units (CFU-Ms) committed to macrophage-lineage cells. We assessed the origins of tissue macrophage colony-forming cells (M-CFCs) in mice by comparing their kinetics and radiosensitivities in the normal steady state and under the conditions of bone marrow depletion by [sup 89]Sr-administration and/or splenectomy. The results indicate that the radiosensitive peritoneal M-CFCs elicited by thioglycollate are derived from bone marrow macrophage precursors; where as alveolar M-CFCs, which are radioresistant, are self-sustained locally and independent of hemopoietic macrophage precursors. In contrast, highly radiosensitive liver M-CFCs are probably derived from CFU-Ms that appear to be propagated in the spleen in association with hemopoietic responses. (author).
1992-12-01
Energy Technology Data Exchange (ETDEWEB)
Femaxi-iv is a computer code for the analysis of thermal and mechanical behavior of light water reactor fuel rods during steady-state and transient conditions. The main purpose of femaxi-iv is to calculate the stress and strain distributions in the fuel and cladding due to the pellet-cladding mechanical interaction, and the fission gas release rate during operations, especially power transients. The capability of femaxi-iv was extensively tested with a number of experimental results obtained in some international fuel irradiation programs. This paper provides a general description of the various models involved in femaxi-iv and some results of applications on the experimental data. ((orig.))
1994-06-01
International Nuclear Information System (INIS)
The electrically heated rod is usually used as a substitute for fuel rod in thermal-hydraulic experiment. However, the different structure and thermal properties between nuclear fuel rod and electrically heated rod result in different steady-state distribution of temperature and stored energy and different response to thermal-hydraulic in simulation transient experiment. This paper analyses the effect of structure and thermal properties differences between nuclear fuel rod and electrically heated rod on experiment, and then introduce a feasible method, i.e. electric power is controlled by a program, to reduce the differences between the transient responses of nuclear fuel rod and electrically heated rod. At the same time, this paper points out the limits of the method. (authors)
2004-09-01
ELECTROMAGNETIC AND THERMAL SIMULATIONS FOR THE SWITCH REGION OF A COMPACT PROTON ACCELERATOR
Energy Technology Data Exchange (ETDEWEB)
A compact proton accelerator for medical applications is being developed at Lawrence Livermore National Laboratory. The accelerator architecture is based on the dielectric wall accelerator (DWA) concept. One critical area to consider is the switch region. Electric field simulations and thermal calculations of the switch area were performed to help determine the operating limits of rmed SiC switches. Different geometries were considered for the field simulation including the shape of the thin Indium solder meniscus between the electrodes and SiC. Electric field simulations were also utilized to demonstrate how the field stress could be reduced. Both transient and steady steady-state thermal simulations were analyzed to find the average power capability of the switches.
2007-06-15
Energy Technology Data Exchange (ETDEWEB)
This paper presents the results of the dynamic response analysis of the pipe-restraints system by the general purpose finite element program ADINA. The analysis was carried out for the pipe whip tests performed under the PWR-LOCA conditions using 4-in. test pipe. In the analysis, the test pipe was modeled by an assemblage of the beam elements with the isotropic elastic-plastic material properties and the restraints were represented by the truss elements with the nonlinear elastic material properties including gap effect. The following results are obtained through the analysis. (1) Pipe can be modeled with the beam elements, when the overhang length is short and, therefore, the flattening of a cross-section of pipe is small. (2) The steady state restraint force can be predicted by modeling the restraints with the truss elements.
1983-09-01
Energy Technology Data Exchange (ETDEWEB)
The code is being developed starting from the steady-state finite element code FENDER for the solution of the diffusion equation by extending it to become time-dependent. The numerical solution of the time-dependent multigroup diffusion equations within TRANSFUSION is performed at the present stage of development by using a backward difference scheme for the time variable, leading to a rearrangement of FENDER by adding a new loop over time steps. The code retains the multigroup coupled neutron-gamma features of FENDER, and provides a consistent two-, and quasi three-dimensional numerical solution of both static and time-dependent multigroup diffusion equations. (orig./DG)
1993-04-01
Current drive and heating systems based on high-energy (1- to 3-MeV) negative ion beams
Energy Technology Data Exchange (ETDEWEB)
This paper describes a concept for a current drive system based on negative ions with beam energy > 1 MeV. Preliminary physics calculations show that the core current necessary for stability enhancement can best be achieved by beams with energy ranging from 1 to 4 MeV. Further study and experiments will better define the optimum energy. Work under way at Oak Ridge National Laboratory (ORNL) and at collaborating institutes in Canada and the Federal Republic of Germany is defining a system, its elements, a configuration and operational scenarios deemed appropriate for such devices as ITER and other future steady-state tokamaks, and the requisite research and development to provide such a system. 7 refs., 2 figs.
1988-01-01
Concordant Chemical Reaction Networks
We describe a large class of chemical reaction networks, those endowed with a subtle structural property called concordance. We show that the class of concordant networks coincides precisely with the class of networks which, when taken with any weakly monotonic kinetics, invariably give rise to kinetic systems that are injective --- a quality that, among other things, precludes the possibility of switch-like transitions between distinct positive steady states. We also provide persistence characteristics of concordant networks, instability implications of discordance, and consequences of stronger variants of concordance. Some of our results are in the spirit of recent ones by Banaji and Craciun, but here we do not require that every species suffer a degradation reaction. This is especially important in studying biochemical networks, for which it is rare to have all species degrade.
2011-01-01
Collisionless driven reconnection in an open system
Energy Technology Data Exchange (ETDEWEB)
Particle simulation studies of collisionless driven reconnection in an open system are presented. Collisionless reconnection evolves in two steps in accordance with the formation of two current layers, i.e., an ion current layer in the early ion phase and an electron current layer in the late electron phase. After the electron current layer is formed inside the ion current layer, the system relaxes gradually to a steady state when convergent plasma flow is driven by an external electric field with a narrow input window. On the other hand, when the convergent plasma flow is driven from the wide input window, magnetic reconnection takes place in an intermittent manner, due to the frequent formation of magnetic islands in the vicinity of neutral sheet. (author)
2000-06-01
CANDU 6 fuel behaviour in power ramp conditions
International Nuclear Information System (INIS)
The facilities in the Institute for Nuclear Research at Pitesti allow the testing, handling and examination of nuclear fuel and irradiated materials. The most important facilities are the TRIGA Steady State Research and Material Test Reactor and the Post-Irradiation Examination Laboratory (PIEL). The purpose of this work is to determine by post-irradiation examination, the behavior of CANDU fuel, irradiated in 14 MW TRIGA reactor. The fuel was irradiated in power ramp conditions. The results of post-irradiation examination are: - Visual inspection and photography of the outer appearance of sheath; - Profilometry (diameter, bending, ovality) and length measuring; - Determination of axial and radial distribution of the fusion products activity by gamma scanning and tomography; - Microstructural characterization by metallographic and ceramographic analyzes; - Mechanical properties determination. The data obtained from the post-irradiation ...
2009-10-12
Approximate solutions to the Stefan problem with internal heat generation
Energy Technology Data Exchange (ETDEWEB)
Using a quasi-static approach valid for Stefan numbers less than one, we derive approximate equations governing the movement of a phase change front for materials which generate internal heat. These models are applied for both constant surface temperature and constant surface heat flux boundary conditions, in cylindrical, spherical, plane wall and semi-infinite geometries. Exact solutions with the constant surface temperature condition are obtained for the steady-state solidification thickness using the cylinder, sphere, and plane wall geometries which show that the thickness depends on the inverse square root of the internal heat generation. Under constant surface heat flux conditions, closed form equations can be obtained for the three geometries. In the case of the semi-infinite wall, we show that for constant temperature and constant heat flux out of the wall conditions, the solidification layer grows then remelts. (orig.)
2008-05-15
Applicator reconstruction and applicator shifts in 3D MR-based PDR brachytherapy of cervical cancer
British Library Electronic Table of Contents (United Kingdom)
Purpose To evaluate the methods of applicator reconstruction in 3D MR-based planning for brachytherapy of cervical cancer, and to investigate applicator shifts and changes in DVH parameters during PDR treatment. Methods For each application MR scans with applicator in situ were made: three T2-weighted (4.5mm slices) Turbo Spin Echo (TSE) scans and a balanced Steady State Free Precession scan (1.5mm). Three observers tested two applicator reconstruction methods: (A) directly on the bSSFP scan and (B) on a resampled combination of the three T2-weighted scans. For 10 patients MR imaging was repeated on the second day of each PDR fraction to determine applicator shifts and changes in DVH parameters. Results For both applicator reconstruction methods the interobserver variation for the DVH para...
2009-01-01
Anomalous activity of nonbasal dislocations in AZ31 Mg alloys at room temperature
Energy Technology Data Exchange (ETDEWEB)
AZ31 Mg alloy samples were extruded by an equal channel angular extrusion (ECAE) process and subsequently annealed to obtain fine-grained material with a low dislocation density. Tensile tests at room temperature exhibited an apparent steady-state deformation region and a large tensile elongation of 47%. The deformed microstructure at an elongation of 2% indicated a substantial cross-slip to nonbasal planes possibly induced by grain-boundary compatibility effects. The nonbasal segments of dislocations were found to consist of 40% of the total dislocation density at a yield anisotropy factor of only 1.1 instead of an expected value of 100 from single-crystal experiments. (orig.)
2003-07-01
Energy Technology Data Exchange (ETDEWEB)
In this paper, a complete solution of the steady-state Newton-Euler equations describing the motion of the balls in high speed thrust bill bearings is presented. Kinematic equations are derived and used as ancillary equations to obtain the numerical solution of the Newton-Euler equations. This differs from previously reported work where extraneous assumptions (instead of kinematic analysis) are used to allow solutions of these equations. It is shown that the no-slip condition for the ball motion reported in the literature is based on an unnecessary assumption. The correct form of the condition is developed and used in the analysis of the ball motion. The analysis shows the importance of contact angle on both ball motion and contact force. An approximate theory is then developed for determining the optimum contact angle that would result in minimum contact force in high speed ball bearings. The results are compared with experimental data, and theory is illustrated ...
1991-12-31
An investigation of the thermal performance of an oil filled transformer winding
Energy Technology Data Exchange (ETDEWEB)
Manufacturers may be required to design transformers to overload specifications. Oil viscosity changes and loss variation with temperature are not accounted for in the industry loading guide. A comprehensive test program was performed using a winding assembly with imbedded thermocouples. Steady state and transient tests were performed for natural and non-directed forced oil circulation. The temperature distribution in the winding was not linear with height as usually assumed. A large number of temperature sensors is required to determine the hot spot location. The location of the hot spot was found to be different and less predictable for natural oil circulation compared with non-directed forced oil circulation especially during overload conditions. This paper reports that improved loading guide equations were developed to account for oil viscosity, resistance change, cooling duct oil rise, and location of the hot spot.
1992-07-01
A unified framework for biological evolution and stochastic quantization
We investigate the profound relation between the equations of biological evolution and quantum mechanics by writing a biologically inspired equation for the stochastic dynamics of an ensemble of particles. Interesting behavior is observed which is related to a new type of stochastic quantization. We find that the probability distribution of the ensemble of particles can be decomposed into eigenfunctions associated to a discrete spectrum of eigenvalues. In absence of interactions between the particles, the out-of-equilibrium dynamics asymptotically relaxes towards the fundamental state. This phenomenon can be related with the Fisher theorem in biology. On the contrary, in presence of scattering processes the evolution reaches a steady state in which the distribution of the ensemble of particles is characterized by a Bose-Einstein statistics. In order to show a concrete example of this stochastic quantization we have solved explicitly the case in ...
2010-01-01
British Library Electronic Table of Contents (United Kingdom)
A new numerical technique called the convolution-based particle tracking (CBPT) method is developed to simulate resident or flux-averaged solute concentrations in groundwater models. The method is valid for steady-state flow and linear transport processes such as sorption with a linear sorption isotherm and first-order decay. The CBPT method uses particle tracking to take advantage of the ability of particle-based approaches to maintain sharp fronts for advection-dominated transport problems common in groundwater modeling and because of the flexibility of the random walk method to simulate a wide range of possible forms of the dispersion tensor. Furthermore, the algorithm for carrying out the convolution and superposition calculation from particle tracking results is very efficient. We sho...
2010-01-01
British Library Electronic Table of Contents (United Kingdom)
A one-dimensional, steady-state, two-phase direct methanol fuel cell (DMFC) model is developed to precisely investigate complex physiochemical phenomena inside DMFCs. In this model, two-phase species transport through the porous components of a DMFC is formulated based on Maxwell-Stefan multi-component diffusion equations, while capillary-induced liquid flow in the porous media is described by Darcy's equation. In addition, the model fully accounts for water and methanol crossover through the membrane, which is driven by the effects of electro-osmotic drag, diffusion, and the hydraulic pressure gradient. The developed model is validated against readily available experimental data in the literature. Then, a parametric study is carried out to investigate the effects of the operating temperat...
2010-01-01
British Library Electronic Table of Contents (United Kingdom)
Abstract Aims: To develop an in vitro flat-bed perfusion biofilm model that could be used to determine the antimicrobial efficacy of topically applied treatments. Methods and Results: Pseudomonas aeruginosa and Staphylococcus aureus biofilms were grown within continuously perfused cellulose matrices. Enumeration of the biofilm density and eluate was performed at various sampling times, enabling determination of the biofilm growth rate. Two antimicrobial wound dressings were applied to the surface of mature biofilms and periodically sampled. To enable real-time imaging of biofilm growth and potential antimicrobial kinetics, a bioluminescent Ps. aeruginosa biofilm was monitored using low-light photometry. Target species produced reproducible steady-state biofilms at a density of c. 107 per b...
2009-01-01
A nodal integral method for neutron diffusion in hexagonal geometry
International Nuclear Information System (INIS)
A nodal integral method is derived for the monoenergetic, steady-state, fixed source neutron diffusion equation in hexagonal geometry based on a coordinate transformation that maps a parallelogram into a rectangle. The new hexagonal nodal diffusion method is implemented in the computer code HND where the discrete-variable equations are solved via an iterative scheme. Because the new method's equations are derived for a rhombus, they can be solved on a sequence of embedded meshes to study the method's error order. Indeed a preliminary numerical error analysis reveals a second-order error in the mesh size, and comparison with finite difference results obtained with the finite difference based BOLD-VENTURE code indicate the superior accuracy of our new nodal method.
1992-03-08
British Library Electronic Table of Contents (United Kingdom)
An appropriate mathematical model can help researchers to simulate, evaluate, and control a proton exchange membrane fuel cell (PEMFC) stack system. Because a PEMFC is a nonlinear and strongly coupled system, many assumptions and approximations are considered during modeling. Therefore, some differences are found between model results and the real performance of PEMFCs. To increase the precision of the models so that they can describe better the actual performance, optimization of PEMFC model parameters is essential. In this paper, an artificial bee swarm optimization algorithm, called ABSO, is proposed for optimizing the parameters of a steady-state PEMFC stack model suitable for electrical engineering applications. For studying the usefulness of the proposed algorithm, ABSO-based results...
2011-01-01
Cognitive performance correlates with cerebrovascular impairments in multi-infarct dementia
International Nuclear Information System (INIS)
Cerebral blood flow (CBF) was measured by the "1"3"3Xe inhalation method in patients with multi-infarct dementia (MID, N = 26), Alzheimer's dementia (AD, N = 19), and among age-matched, neurologically normal, healthy volunteers (N = 26). Cognitive performance was assessed in all subjects using the Cognitive Capacity Screening Examination (CCSE). Cerebral vasomotor responses were calculated from differences in values of mean hemispheric gray matter blood flow (Delta CBF) measured during inhalation of 100% oxygen (hyperoxia) compared with CBF measured while breathing room air. Significant correlations were found between CCSE performance and vasomotor responsiveness in patients with MID (P less than .01), but not in patients with AD or in neurologically normal volunteers. Loss of vasomotor responsiveness is an indicator of cerebrovascular disease with rigidity and/or loss of reactivity of cerebral vessels, which impairs ...
Energy Technology Data Exchange (ETDEWEB)
Inverted annular flow can be visualized as a liquid jet-like core surrounded by a vapor annulus. While many analytical and experimental studies of heat transfer in this regime have been performed, there is very little understanding of the basic hydrodynamics of the post-CHF flow field. However, a recent experimental study was done that was able to successfully investigate the effects of various steady-state inlet flow parameters on the post-CHF hydrodynamics of the film boiling of a single phase liquid jet. This study was carried out by means of a visual photographic analysis of an idealized single phase core inverted annular flow initial geometry (single phase liquid jet core surrounded by a coaxial annulus of gas). In order to extend this study, a subsequent flow visualization of an idealized two-phase core inverted annular flow geometry (two-phase central jet core, surrounded by a coaxial annulus of gas) was carried out. The objective of this second experimental ...
1988-01-01
Transient Critical Heat Flux tests on a rod bundle simulating Pressurized Water Reactors
International Nuclear Information System (INIS)
Transients induced in nuclear power plants from many sources result in one or more fluid conditions changing with time. Fluid conditions of pressure, inlet temperature, inlet flow, or even system power many change separately or in conjunction with each other. The result of the condition change may be one which induces departure from nucleate boiling. An experimental investigation of transient which were intended to achieve Critical Heat Flux was performed at the Heat Transfer Research Facility of Columbia University for Siemens Nuclear Power Corporation. The transients were set up to include broad ranges of flow and pressure conditions near the operating range of pressurized water reactors. Transient events were dominated by varying single conditions and measuring the response of the system and of the rod thermocouples. Because of coupling effects within the test loop, secondary conditions would also vary. In order to perform controlled tests which achieved the desired result, CHF ...
International Nuclear Information System (INIS)
A theoretical model was developed to simulate this phenomenon, under some specific assumptions. The model simulates: the generation and decay of radon within the soil; its transport throughout the soil due to diffusion and convection induced by the pressure disturbance applied at a crack in the basement; its entrance into the house through the crack; and the resultant indoor radon concentration. The most important assumptions adopted in the model were: a steady-state condition; a house with a basement; a geometrically well-defined crack at the wall-floor joint in the basement; and a constant negative pressure applied at the crack in relation to the outside atmospheric pressure. Two three-dimensional finite-difference computer programs were written to solve the mathematical equations of the model. The first program, called PRESSU, was used to calculate: the pressure distribution within the soil as a result of the applied disturbance pressure at the crack; and the ...
1997-10-16
International Nuclear Information System (INIS)
The anodic reaction kinetics and interfacial mass transport of a direct polymer electrolyte membrane formic acid fuel cell have been investigated in an all solid-state electrochemical cell using a highly active nanostructured palladium-gold alloy microelectrode as an in situ probe. Well-defined 'S-shaped' steady-state cyclic voltammograms exhibiting current-rising region at lower overpotentials and limiting current region at higher overpotentials have been first obtained for the electrochemical oxidation of formic acid at varying temperature. The 'S-shaped' steady state polarization curves and chronoamperometric curves enable convenient measurements of the anodic reaction kinetics and interfacial mass transport of formic acid under real polymer electrolyte membrane conditions. It is encouragingly found that formic acid can be directly oxidized to CO2 with the first electron transfer being the likely rate-determining step ...
2009-07-30
Power control for wind turbines in weak grids: Project summary
Energy Technology Data Exchange (ETDEWEB)
In many parts of the world and certainly in Europe large areas exist where the wind resources are good or very good and the grid is relatively weak due to a small population. In the areas the capacity of the grid can very often be a limiting factor for the exploitation of the wind resource. There are two main problems concerned with wind power and weak grids. The first is the steady state voltage level. The other main problem is voltage fluctuations. Some or all the these problems can be avoided if a so-called power control concept is applied together with the wind farm. The idea behind the power control concept is eliminate the violations of the steady state voltage level by buffering the power from the wind turbines in periods where the voltage limits might be violated and combine this ability with smoothing of the power output. The investigations have shown that the power control concept can compete ...
1999-03-01
International Nuclear Information System (INIS)
Research highlights: ? We model power oscillations in boiling water reactors using a lumped parameter model. ? The nature and amplitudes of oscillations is obtained using a nonlinear analysis. ? The method of multiple scales has been used for the analytical treatment. ? Fuel temperature coefficient of reactivity determines the nature of oscillations. ? The presented systematic method of analysis useful for reduced order reactor models. - Abstract: In this paper, we perform a parametric study of the nonlinear dynamics of a reduced order model for boiling water reactors (BWR) near the Hopf bifurcation point using the method of multiple scales (MMS). Analysis has been performed for general values of the parameters, but the results are demonstrated for parameter values of the model corresponding to the advanced heavy water reactor (AHWR). The neutronics of the AHWR is modeled using point reactor kinetic equations while a one-node lumped parameter model is assumed both for the fuel and the ...
2011-01-01
Investigation of thermohydraulic parameters during natural convection cooling of TRIGA reactor
International Nuclear Information System (INIS)
Important steady-state thermohydraulic parameters of the TRIGA research reactor operating under natural convection mode of coolant flow were investigated using NCTRIGA computer code. Neutronic parameters used in preparing the input of NCTRIGA were taken from the analysis performed by 3-D Monte Carlo code MCNP4C. Benchmarking of the NCTRIGA calculated results were performed against the experimental data measured by the thermocouples in the instrumented fuel element (IFE) during the steady state operation of the reactor under natural convection mode of coolant flow. Various thermohydraulic parameters like the coolant velocity, flow rate and mass flow rate were generated for the hot channel as well as for the two channels comprising instrumented fuels. Calculated peak fuel temperatures at different power levels were compared with the measured values and also with the calculations performed by PARET code. Axial temperature ...
2006-09-01
Influence of Hexagenia on the fate and bioavailability of contaminants in sediment
International Nuclear Information System (INIS)
The influence of sediment dwelling macroinvertebrates on fate and bioavailability of contaminants in freshwater systems was determined using the burrowing mayfly, Hexagenia limbata, as a representative benthic organism. Two series of experiments were conducted: the first to determine the effect of mayflies on movement of contaminants into sediment and organisms, and the second to examine the effect of mayflies on release of contaminants from sediments to the water column and their subsequent accumulation in fish. Concentrations of "1"4C labelled DDT, hexachlorobenzene (HCB), and dihexylphthalate (DHP) in water were 0.11 +/- 0.01, 0.062 +/- 0.005 and 0.006 +/- 0.007 ppb, respectively. Total mass of DHP in the burrow wall was about equal to mass on the surface, indicating that mayflies were capable of doubling the amount of DHP sorbed per unit surface area of sediment. Adsorption of contaminants from water pumped through mayfly burrows increased depth of penetration and mass of DDT, DHP, ...
ERRICCA radon model intercomparison exercise
Energy Technology Data Exchange (ETDEWEB)
Numerical models based on finite-difference or finite-element methods are used by various research groups in studies of radon-222 transport through soil and building materials. Applications range from design of radon remediation systems to more fundamental studies of radon transport. To ascertain that results obtained with these models are of good quality, it is necessary that such models are tested. This document reports on a benchmark test organized by the EU project ERRICCA: European Research into Radon in Construction Concerted Action. The test comprises the following cases: 1) Steady-state diffusive radon profiles in dry and wet soils, 2) steady-state entry of soil gas and radon into a house, 3) time-dependent radon exhalation from a building-material sample. These cases cover features such as: soil heterogeneity, anisotropy, 3D-effects, time dependency, combined advective and diffusive transport of radon, flux calculations, and ...
1999-04-01
Digitonin abolishes free 2-deoxy-D-glucose accumulation in isolated rat adipocytes
Energy Technology Data Exchange (ETDEWEB)
The hypothesis that accumulation against sizable chemical gradients of free (non-phosphorylated) 2-deoxy-D-glucose (2dGlc) in isolated rat adipocytes results from an intracellular compartmentation of free hexose was investigated. Cells exposed to 20 ..mu..g/ml digitonin for 10' demonstrated an increased plasma membrane permeability indexed by increased L-glucose entry rates and cellular (presumably cytosolic) protein and K/sup +/ loss. Functional integrity of intracellular organelles was indicated by the ability of the cells to support ATP-driven /sup 45/Ca/sup 2 +/-uptake. Equilibrium 3-O-methylglucose (3-O-MG, a non-accumulated hexose) levels were unaffected. These data suggest a specific permeabilizing action of digitonin at the plasma membrane having no effect on intracellular organelles or passively distributed solutes. Upon addition of digitonin, free 2dGlc fell from 66.5 +/- 8.9 to 7.4 +/- 2.3 pmol/10/sup 5/ cells, a value not significantly different from 3-O-MG levels. ...
1986-03-05
Energy Technology Data Exchange (ETDEWEB)
Corrosion characteristics of Al and Cu thin films have been studied in cyclic fog tests using tap water fog and fog created with 0.1% NaCl solution in tap water. Likewise, their corrosion features have been analyzed in continuous immersion testing in the laboratory in distilled water, tap water, in 0.1% NaCl and 3.5% NaCl solutions in distilled water. The corrosion potentials and the corrosion currents of these thin films change and reach steady state values after some time. However, steady state is not realized in 3.5% NaCl solutions. The corrosion current density data have been used to calculate lifetime of 1 {mu}m thick thin films of Al and Cu in the various tests, and assuming that the fog test data would hold under normal exposure conditions, life spans for these thin film sensor elements in actual exterior exposure have also been calculated. According to estimates, an Al-TF of about 1 {mu}m would ...
1998-12-31
COOLOD, Steady-State Thermal Hydraulics of Research Reactors
International Nuclear Information System (INIS)
1 - Description of program or function: The COOLOD-N2 code provides a capability for the analyses of the steady-state thermal-hydraulics of research reactors. This code is a revised version of the COOLOD-N code, and is applicable not only for research reactors in which plate-type fuel is adopted, but also for research reactors in which rod-type fuel is adopted. In the code, subroutines to calculate temperature distribution in rod-type fuel have been newly added to the COOLOD-N code. The COOLOD-N2 code can calculate fuel temperatures under both forced convection cooling mode and natural convection cooling mode. A 'Heat Transfer package' is used for calculating heat transfer coefficient, DNB heat flux etc. The 'Heat Transfer package' is a subroutine program and is especially developed for research reactors in which plate-type fuel is adopted. In case of rod-type fuel, DNB heat flux is calculated by both the 'Heat Transfer package' and Lund DNB heat flux correlation ...
Assessing the internal mechanical integrity of power transformers using vibration tests
Energy Technology Data Exchange (ETDEWEB)
Machine condition monitoring (MCM) has the capability to predict equipment maintenance needs which can reduce forced down-time and facilitate the avoidance of catastrophic failures and the consequential secondary damage. It can be used to allow confident deferral of routine maintenance, and improve equipment performance, availability, reliability and safety. In order to capitalize on the potential benefits of MCM directed toward power transformers two types of vibration tests were conducted on transformers owned and operated by Cargill Inc. and IES Utilities at the Bridgeport corn plant in Eddyville, Iowa. These tests involved collecting vibration signals from the transformer tank walls during transformer energization at no-load and during steady state operation at various loads. These vibration signals were then used to detect deterioration of internal mechanical integrity. Both types of tests conducted on the transformers at the Eddyville ...
1996-12-31
Alterations in resting oxygen consumption in women exposed to 10 days of cold air
Energy Technology Data Exchange (ETDEWEB)
Repeated exposure to cold air reduces the metabolic response to cold air exposure in man. The purpose of this investigation was to measure the change in resting metabolic rate (RMR) with exposure to 22C air and 4C air during a 12 day period. Four women sat in 22C air for 45 min followed by 45 min in 4C air each day for ten days. The authors measured RMR during a 45 min period in 22C air followed by 45 min in 4C air on four days. All subjects began their morning exposures on a Monday within 2 days of the onset of menses completing the study on a Friday, 12 days later. Subjects dressed in a T-shirt, shorts and cotton socks. During 45 min of exposure to warm air, RMR remained steady at 10% of VO{sub 2peak} on Day 1 and 10% on Day 5. RMR during exposure to warm air significantly increased to 13% of VO{sub 2peak} on Day 8 and remained elevated at 13% on Day 12. During exposure to cold air RMR peaked at 31% of CO{sub 2peak} by the 5th min on Day 1. Peak RMR on Day 5 was significantly lower. ...
1991-03-11
Diabetic patients have abnormal cerebral autoregulation during cardiopulmonary bypass
Energy Technology Data Exchange (ETDEWEB)
We tested the hypothesis that insulin-dependent diabetic patients with coronary artery bypass graft surgery experience altered coupling of cerebral blood flow and oxygen consumption. In a study of 23 patients (11 diabetics and 12 age-matched controls), cerebral blood flow was measured using 133Xe clearance during nonpulsatile, alpha-stat blood gas managed cardiopulmonary bypass at the conditions of hypothermia and normothermia. In diabetic patients, the cerebral blood flow at 26.6 +/- 2.42 degrees C was 25.3 +/- 14.34 ml/100 g/min and at 36.9 +/- 0.58 degrees C it was 27.3 +/- 7.40 ml/100 g/min (p = NS). The control patients increased cerebral blood flow from 20.7 +/- 6.78 ml/100 g/min at 28.4 +/- 2.81 degrees C to 37.6 +/- 8.81 ml/100 g/min at 36.5 +/- 0.45 degrees C (p less than or equal to 0.005). The oxygen consumption was calculated from jugular bulb effluent and increased from hypothermic values ...
1990-11-01
International Nuclear Information System (INIS)
To test the assumption underlying every morphometric twin study that the brains of monozygotic twins are almost identical. Methods: High resolution MRI of the neurocranium of 26 monozygotic twin pairs were acquired and the volumes of 36 cerebral structures were measured. The same twins served as control group after rear-ranging them into non-related pairs of same sex and matching them for age, body height and body weight. Results: For most of the examined structures the correlations within the twins were significant (R = 0,97-0,59). Except for total forebrain volume the controls showed no significant similarity. Conclusions: For almost every measured cerebral structure the assumption, that significant similarities exist between healthy monozygotic twins is correct. Therefore discordant monozygotic twins represent an excellent sample when investigating cerebral correlates of neurologic and psychiatric disorders. (orig.)
2001-06-01
Synthesis of C-11 iodoantipyrine for positron emission tomography
Energy Technology Data Exchange (ETDEWEB)
We have developed a method for the synthesis of C-11 iodoantipyrine. Carbon-11-labeled methyl iodide, prepared from /sup 11/CO2, was used to methylate 3-methyl-1-phenyl-2-pyrazolin-5-one to form C-11 antipyrine. Following silica-gel column chromatography and iodination, radiochemical purity of the C-11 iodoantipyrine was more than 99.5%, with a 10% yield and a specific activity of 30 mCi/mumol. Preliminary animal studies showed complete cerebral extraction and local cerebral blood-flow values that were within 4.6% of those obtained using C-14 iodoantipyrine. The C-11 analog, with positron emission tomography, will facilitate local cerebral blood-flow studies in human subjects.
1981-06-01
British Library Electronic Table of Contents (United Kingdom)
This study examined whether elevated intravascular pressure stimulates asynchronous Ca2+ waves in cerebral arterial smooth muscle cells and if their generation contributes to myogenic tone development. The endothelium was removed from rat cerebral arteries, which were then mounted in an arteriograph, pressurized (20 100 mmHg) and examined under a variety of experimental conditions. Diameter and membrane potential (VM) were monitored using conventional techniques; Ca2+ wave generation and myosin light chain (MLC20)/MYPT1 (myosin phosphatase targeting subunit) phosphorylation were assessed by confocal microscopy and Western blot analysis, respectively. Elevating intravascular pressure increased the proportion of smooth muscle cells firing asynchronous Ca2+ waves as well as event frequency. C...
2010-01-01
Human brain development in infants with PET and FDG
International Nuclear Information System (INIS)
The authors used studies of local cerebral metabolic rate for glucose (LCMRGlc) to examine development of cerebral organization in 5 days to 1 year old children. A group (n=8) of infants with diverse pediatric disorders allowed investigation of developmental changes in LCMRGlc, while also providing relevant clinical management information. Patients consisted of questionable and definite neonatal seizures, cerebral embolism from cardiac sources, and otherwise normal infants with facial nevi with consideration of Sturge-Weber. Gradual increase in cortical LCMRGlc coincides with suppression of intrinsic subcortical reflexes present in all newborns. Two retarded children (2 years old) showed LCMRGlc developmental patterns of a few days old, which corresponded to their functional and mental status. These studies illustrate great potential of PET to study normal and altered states of human brain development.
1985-06-02
British Library Electronic Table of Contents (United Kingdom)
Ethnopharmacological relevance: Extracts of the roots of Scutellaria baicalensis Georgi (Labiatae) have been widely used to relieve fever related to bacterial infection and inflammatory diseases in traditional Korean medicine and have been reported to be effective in brain diseases. These experiments were conducted to examine the effects of oral administration of Scutellaria baicalensis extracts on the rescue of memory impairments induced by chronic cerebral hypoperfusion or chronic lipopolysaccharide (LPS) infusion. In addition, the underlying mechanisms of these effects were investigated. Materials and methods: In the first experiment, chronic cerebral hypoperfusion was induced in male Wister rats by bilateral common carotid artery occlusion (BCCAo). Daily administration of Scutellaria b...
2011-01-01
Energy Technology Data Exchange (ETDEWEB)
Introduction: The goal of this study was to compare contrast-enhanced T1-weighted Flash and Turbo-Flash sequences with conventional spin-echo sequences as a basis for planning high-precision radiotherapy. Methods: A total of 25 consecutive patients with different intracranial tumors and a disrupted blood-brain barrier were studied. T1-weighted Flash, Turbo-Flash and conventional spin-echo images were evaluated after controlled 30-s infusion of 0.1 mmol/kg body weight of Gd-DTPA. The evaluation of the three sequences included the measurement of the signal- and contrast-to-noise ratios, the visual inspection of the tumors and artifacts, and the measurement of tumor size. Results: The signal- and contrast-to-noise ratios were significantly (P<0.05-0.01) lower for Flash and Turbo-Flash than for conventional spin-echo sequences. However, visual inspection of the ...
1997-03-01
Energy Technology Data Exchange (ETDEWEB)
Tumours lesions of the temporal bone and of the cerebello-pontine angle are rare.This tumours can be separated into benign and malignant lesions. In this paper the CT and MRI characteristica of tumours of the temporal bone and the cerebello-pontane angle will be demonstrated. High resolution CT (HRCT) as usually performed in the axial plane are using a high resolution bone window level setting, coronal planes are the reconstructed from the axial data set or will be obtained directly. With the MRI FLAIR sequence in the axial plane the whole brain will be scanned either to depict or exclude a tumour invasion into the brain. After this,T2-weighted fast spin echo sequences or fatsuppressed inversion recovery sequences in high resolution technique in the axial plane will be obtained from the temporal bone and axial T1-weighted spinecho sequences before and after the intravenous application of contrast material will be obtained ...
2003-03-01
Primary malignant lymphoma of the brain; Primaere maligne Lymphome des Gehirns
Energy Technology Data Exchange (ETDEWEB)
Primary malignant lymphoma of the brain is a disease of unknown etiology, which is increasing in incidence and has an unfavorable prognosis. Despite the lack of specific changes on CT or MRI in most cases, these procedures may typically facilitate the diagnosis: A focal-enhancing mass with subependymal spread on CT or MRI and hyperattenuation on nonenhanced CT are the most reliable features in the diagnosis of primary malignant lymphoma of the brain. Peritumoral edema and mass effect are usually not prominent features. On unenhanced CT scans they usually appear homogeneously isodense to mildly hyperdense relative to the gray matter. On MRI these tumors are slightly hypointense on T1-weighted images and slightly hpyerintense on PD- and T2-weighted images relative to the gray matter. On CT and MRI enhancement is usually homogeneous. Contrast-enhanced MRI, with its multiplanar capability, lack of bone-induced artifacts, and ...
1997-01-01
Energy Technology Data Exchange (ETDEWEB)
This contribution provides an overview and imparts basic knowledge on pertinent technical developments in magnetic resonance imaging (MRI) of the liver: 3D sequences, respiratory triggering, parallel imaging, and 3 Tesla (3T). 3D sequences can be used as T1-weighted (T1w) sequences for analyzing dynamics of contrast enhancement or as T2w sequences for MR cholangiography. Consistent improvements in respiratory triggering make it possible to obtain good image quality on T2w scans even in patients unable to hold their breath. Parallel imaging as a universal technique to accelerate image acquisition is particularly appropriate for MRI of the liver, and it has been shown that the reduced acquisition time is not achieved at the expense of image quality. Further progress in MRI of the liver can be expected with use of the 3T systems, but hitherto irrelevant problems must still be solved. Overall the innovations presented here, ...
2004-12-01
Energy Technology Data Exchange (ETDEWEB)
Minimally invasive thermotherapies for focal tissue destruction on the basis of laser-, microwave-, focused ultrasound-, or cryogeninduced changes of tissue temperature represent an alternative to surgical tissue ablation, particularly in the treatment of tumors. The thermotherapy modalities listed necessitate indirect guidance and monitoring, since they often do not lend themselves to immediate visual control. In the brain, in head and neck tumors, in the liver, and in the prostate, MRI reliably and accurately delineates both the positions of interstitial thermotherapy applicators and - in contrast-enhanced, T1-weighted images - the perfusion defects in tissue necrosis induced by thermotherapy. The transfer of results of in-vitro and in-vivo model studies to assess interstitial temperature and lesion development during thermotherapy to the actual treatment of patients, however, is still in an initial phase. Further ...
1998-03-01
UK PubMed Central (United Kingdom)
The subtemporal approach with division of the posterior communicating artery (PcomA) is described for treating aneurysms of the basilar tip. When the ipsilateral posterior cerebral artery (PCA) interferes...Full Text Available
2008-08-01
Reduced sample sizes for atrophy outcomes in Alzheimer's disease trials: baseline adjustment
UK PubMed Central (United Kingdom)
Cerebral atrophy rate is increasingly used as an outcome measure for Alzheimer's disease (AD) trials. We used the Alzheimer's disease Neuroimaging initiative (ADNI) dataset to assess if adjusting...Full Text Available
2010-08-01
Radiopharmaceuticals for the imaging of functional abnormalities of the developing brain
International Nuclear Information System (INIS)
The measurement of physiological parameters in man is possible with the help of positron emission tomography (PET) and radiopharmaceuticals labeled with short lived positron emitters as C 11, N 13, O 15 and F 18. With the use of this substances it is possible to make a tomographic map defining regional metabolic parameters in normal and diseased brain. This technique has therefore also be named 'in vivo autoradiography'. The possibility of applying C 11 or F 18 labeled deoxyglucose with PET for detecting regional and local changes in cerebral metabolic rate of glucose in brain development in children of 5 days to 1 year of age is discussed. Beyond this a relationship between cerebral metabolic rate of glucose, cerebral blood flow and cerebral metabolic rate of oxygen by use of this technique after inhalation of O 15 and C 11-labeled CO_2 is shown. Attention is drawn to the application of C ...
UK PubMed Central (United Kingdom)
Background:An association has been reported between the dominant nostril through which we breathe and the cerebral hemisphere found to be active.Aims:To...Full Text Available
2008-07-01
UK PubMed Central (United Kingdom)
The effects of paeoniflorin (PF), a compound isolated from Paeony radix, on neurological impairment and histologically measured infarction volume...Full Text Available
2005-10-01
Neurocysticercosis Involving the Pituitary Stalk : Case Report and Literature Review
UK PubMed Central (United Kingdom)
Neurocysticercosis (NCC) is the most common parasitic infestation of the central nervous system. Most cases of NCC are to related and/or associated with inflammation within the cerebral parenchyma....Full Text Available
2010-07-01
International Nuclear Information System (INIS)
Iodixanol is a new nonionic dimer, isotonic with blood at all clinically relevant concentrations. Iodixanol (270 mg I/ml) was compared in a double-blind, randomized, parallel-group, phase-III study to the monomeric nonionic iohexol (300 mg I/ml) for evaluation of safety, tolerability and radiographic efficacy during cerebral CT. One hundred adult patients scheduled to undergo contrast-enhanced cerebral CT were randomly allocated to receive either iodixanol or iohexol. All completed the trial. Safety was evaluated by recording discomfort and other adverse events, tolerance by assessing intensity and incidence of discomfort. Radiographic efficacy was assessed from the diagnostic information and the radiographic density. No serious adverse events occurred. One patient (2 %) in the iodixanol group and one patient (2 %) in the iohexol group experienced a transient reddening at the neck and lower neck-line, respectively. Both contrast agents were ...
1999-09-01
Four Cases of a Cerebral Air Embolism Complicating a Percutaneous Transthoracic Needle Biopsy
UK PubMed Central (United Kingdom)
A percutaneous transthoracic needle biopsy is a common procedure in the practice of pulmonology. An air embolism is a rare but potentially fatal complication of a percutaneous transthoracic needle biopsy....Full Text Available
2009-01-01
UK PubMed Central (United Kingdom)
BackgroundAcute low back pain is a very common symptom and reason for many medical consultations. In some unusual circumstances it could be linked to a rare aetiology.Case...Full Text Available
Cerebral calcification and learning disabilities following cranial irradiation for medulloblastoma.
UK PubMed Central (United Kingdom)
Six children who received craniospinal irradiation for medulloblastoma when they were under 10 years of age developed learning disabilities. Four exhibited associated temporal lobe calcification on...Full Text Available
1990-12-01
Basilar artery aneurysm with autonomic features: an interesting pathophysiological problem
UK PubMed Central (United Kingdom)
Unruptured cerebral aneurysms often present with neuro-ophthalmological symptoms but ocular autonomic involvement from an aneurysm of the posterior circulation has not previously been reported. A patient...Full Text Available
2001-12-01
UK PubMed Central (United Kingdom)
Over the last century, anatomical studies have shown that the cerebral cortex can be subdivided into structurally distinct regions, giving rise to a new branch of neuroanatomy: ‘architectonics’....Full Text Available
2007-08-01
Energy Technology Data Exchange (ETDEWEB)
We report a 20-year-old woman who suffered headaches before presenting with a state of fluctuating vigilance. MRI showed diffuse high signal in the basal ganglia bilaterally on diffusion- and T2-weighted images, which had areas of both low and high apparent diffusion coefficient, presumed to correspond to cytotoxic and vasogenic oedema. MR venography showed no flow in the deep cerebral veins or straight sinus. Heparin was given, with clinical recovery. On follow-up MRI, the appearances became normal. (orig.)
2000-10-01
British Library Electronic Table of Contents (United Kingdom)
Trastuzumab increases survival amongst women with human epidermal growth factor receptor (HER)-2 receptor positive metastatic breast cancer, but maternal and fetal risks are associated with advanced disease and its treatment in pregnancy. We present a case of a primigravid with HER-2 positive metastatic breast cancer who received trastuzumab throughout pregnancy. She presented with cerebral metastases, requiring surgical decompression and resection. Reversible oligohydramnios developed during pregnancy. Fetal safety data on trastuzumab in pregnancy is limited, but case reports suggest a recurring pattern of (mostly reversible) oligohydramnios.
2011-01-01
This report presents the operating results for Run 245 at the Advanced Coal Liquefaction R and D Facility in Wilsonville, Alabama. This run was made in an all-distillate Integrated Two-Stage Liquefaction (ITSL) mode using Illinois 6 coal from the Burning Star mine. The primary run objective was to obtain steady-state ITSL performance by replacing spent HTR reactor catalyst with fresh, sulfided catalyst. Secondary objectives were to maintain an all-distillate (minimum resid production) product slate and to demonstrate the effects of catalyst addition on the net gas production and hydrogen consumption. Run 245 began on 7 November, 1983, and continued through 12 February, 1984. During this period, 179.0 tons of coal was fed in 2045 hours of operation. Eight special product workup material balances were defined, and the results are presented herein. 6 references, 28 figures, 20 tables.
1984-10-01
Water management studies in PEM fuel cells, Part I: Fuel cell design and in situ water distributions
Energy Technology Data Exchange (ETDEWEB)
A proton exchange membrane fuel cell (PEMFC) must maintain a balance between the hydration level required for efficient proton transfer and excess liquid water that can impede the flow of gases to the electrodes where the reactions take place. Therefore, it is critically important to understand the two-phase flow of liquid water combined with either the hydrogen (anode) or air (cathode) streams. In this paper, we describe the design of an in situ test apparatus that enables investigation of two-phase channel flow within PEMFCs, including the flow of water from the porous gas diffusion layer (GDL) into the channel gas flows; the flow of water within the bipolar plate channels themselves; and the dynamics of flow through multiple channels connected to common manifolds which maintain a uniform pressure differential across all possible flow paths. These two-phase flow effects have been studied at relatively low operating temperatures under steady-state conditions and ...
2009-05-15
Validation of the 3D finite element transport theory code EVENT for shielding applications
Energy Technology Data Exchange (ETDEWEB)
This paper is concerned with the validation of the 3D deterministic neutral-particle transport theory code EVENT for shielding applications. The code is based on the finite element-spherical harmonics (FE-P{sub N}) method which has been extensively developed over the last decade. A general multi-group, anisotropic scattering formalism enables the code to address realistic steady state and time dependent, multi-dimensional coupled neutron/gamma radiation transport problems involving high scattering and deep penetration alike. The powerful geometrical flexibility and competitive computational effort makes the code an attractive tool for shielding applications. In recognition of this, EVENT is currently in the process of being adopted by the UK nuclear industry. The theory behind EVENT is described and its numerical implementation is outlined. Numerical results obtained by the code are compared with predictions of the Monte Carlo code MCBEND and ...
2000-03-01
Unsaturated zone flow modeling for GWTT-95
Energy Technology Data Exchange (ETDEWEB)
In accordance with the Nuclear Regulatory Commission regulation regarding groundwater travel times at geologic repositories, various models of unsaturated flow in fractured tuff have been developed and implemented to assess groundwater travel times at the potential repository at Yucca Mountain, Nevada. Kaplan used one-dimensional models to describe the uncertainty and sensitivity of travel times to various processes at Yucca Mountain. Robey and Arnold et al. used a two-dimensional equivalent continuum model (ECM) with inter- and intra-unit heterogeneity in an attempt to assess fast-flow paths through the unsaturated, fractured tuff at Yucca Mountain (GWTT-94). However, significant flow through the fractures in previous models was not simulated due to the characteristics of the ECM, which requires the matrix to be nearly saturated before flow through the fractures is initiated. In the current study (GWTT-95), four two-dimensional cross-sections at Yucca Mountain are simulated using both ...
1995-12-31
Two-phase flow regime management for in-space power rejection management -- Feasibility study
Energy Technology Data Exchange (ETDEWEB)
A novel two-phase flow management process useful for active thermal power rejection in space is introduced. The process serves as a condenser in a Rankine cycle and is applicable for thermal energy management needs in low gravity environments. Benefit is derived from the ability to utilize the high specific energy transport capability of two-phase flow, while not requiring mass-intensive solutions nor complex control strategies to maintain design energy balance integrity. Initial design calculations for a hypothetical space vapor cycle demonstration experiment were done and a steady-state computer model of the novel condensing process was created and used to evaluate its potential to maintain the design energy balance of the experiment. The experiment (approximately 28 kg) was a supercritical organic thermal loop operating between 500 and 400 Kelvin at a mass flow of 1 grain per second; using R-113 as the working fluid and rejecting all of its generated thermal ...
1995-12-31
Two-fluid modeling of condensation in the presence of noncondensables in two-phase channel flows
Energy Technology Data Exchange (ETDEWEB)
Condensing two-phase channel flow occurs in many industrial applications, including heating and refrigeration systems. It can also occur in certain nuclear reactor accidents. For example, during a small-break loss-of-coolant accident in a pressurized water reactor, following the partial depletion of the primary coolant, condensation of steam on the primary side of the steam generator tubes can provide a heat sink for disposal of the decay heat generated in the reactor core. Condensing two-phase flow can also play an important role in the operation of the passive emergency cooling system in the advanced simplified boiling water reactor. Here, steady-state condensation in the presence of a noncondensable in a concurrent two-phase channel flow is analyzed using a two-fluid model. The effect of noncondensables on the combined heat transfer at the liquid-gas mixture interphase is accounted for by using the stagnant film model, and closure relations relevant to the ...
1995-01-01
Transient enhanced diffusion in preamorphized silicon: the role of the surface
Energy Technology Data Exchange (ETDEWEB)
Experiments on the depth dependence of transient enhanced diffusion (TED) of boron during rapid thermal annealing of Ge-preamorphized layers reveal a linear decrease in the diffusion enhancement between the end-of-range (EOR) defect band and the surface. This behavior, which indicates a quasi-steady-state distribution of excess interstitials, emitted from the EOR band and absorbed at the surface, is observed for annealing times as short as 1 s at 900 deg. C. Using an etching procedure we vary the distance x{sub EOR} from the EOR band to the surface in the range 80-175 nm, and observe how this influences the interstitial supersaturation, s(x). The supersaturations at the EOR band and the surface remain unchanged, while the gradient ds/dx, and thus the flux to the surface, varies inversely with x{sub EOR}. This confirms the validity of earlier modelling of EOR defect evolution in terms of Ostwald ripening, and provides conclusive evidence that the surface is the ...
1999-01-02
Transient enhanced diffusion in preamorphized silicon: the role of the surface
International Nuclear Information System (INIS)
Experiments on the depth dependence of transient enhanced diffusion (TED) of boron during rapid thermal annealing of Ge-preamorphized layers reveal a linear decrease in the diffusion enhancement between the end-of-range (EOR) defect band and the surface. This behavior, which indicates a quasi-steady-state distribution of excess interstitials, emitted from the EOR band and absorbed at the surface, is observed for annealing times as short as 1 s at 900 deg. C. Using an etching procedure we vary the distance x_E_O_R from the EOR band to the surface in the range 80-175 nm, and observe how this influences the interstitial supersaturation, s(x). The supersaturations at the EOR band and the surface remain unchanged, while the gradient ds/dx, and thus the flux to the surface, varies inversely with x_E_O_R. This confirms the validity of earlier modelling of EOR defect evolution in terms of Ostwald ripening, and provides conclusive evidence that the surface is the dominant ...
1999-01-02
British Library Electronic Table of Contents (United Kingdom)
The levels of General Transcription Factor (TF) IIA were examined during mammalian brain development and in rat embryo fibroblasts and transformed cell lines. The large TFIIA subunit paralogues ab and t are largely produced in unsynchronized cell lines, yet only TFIIA ab is observed in a number of differentiated tissue extracts. Steady-state protein levels of the TFIIA t, ab, and g subunits were significantly reduced when human embryonal (ec) and hepatic carcinoma cell lines were stimulated to differentiate with either all-trans-retinoic acid (ATRA) or sodium butyrate. ATRA-treated NT2-ec cells required replating to induce a neuronal phenotype and loss of detectable TFIIA t and g proteins. High levels of TFIIA t, ab, and g and Sp factors were identified in extracts from human fetal and rat...
2006-01-01
Energy Technology Data Exchange (ETDEWEB)
The Two-Beam Accelerator (TBA) consists of a long high-gradient accelerator structure (HGS) adjacent to an equal-length Free Electron Laser (FEL). In the FEL, a beam propagates through a long series of undulators. At regular intervals, waveguides couple microwave power out of the FEL into the HGS. To replenish energy given up by the FEL beam to the microwave field induction accelerator units are placed periodically along the length or the FEL. In this manner it is expected to achieve gradients of more than 250 MV/m and thus have serious option for a 1 TeV /times/ 1 TeV linear collider. The state of present theoretical understanding of the TBA is presented with particular emphasis upon operation of the ''steady-state'' FEL, phase and amplitude control of the rf wave, and suppression of sideband instabilities. Experimental work has focused upon the development of a suitable HGS and the testing of this structure using the Electron ...
1987-08-01
International Nuclear Information System (INIS)
Experimental and theoretical work have been carried out to find out the effects of heat transfer augmentation on two-phase flow instabilities in a single channel system. The effect of mass flow rate, heat input and inlet subcooling on the system behavior is studied using Freon-11 as the test fluid and six different heater surfaces are tested at various experimental conditions. Experimental evaluation is done using the steady-state pressure drop versus mass flow rate curves along with the curves of additional inlet pressure drop required to stabilize the system during the oscillations, and tables generated using the experimental data. Homogeneous equilibrium flow model and finite differences are used in theoretical analysis. An empirical relationship is obtained to calculate the pressure drop across the exit restriction. Characteristic equation for the system is found by linearizing the dynamic equations of the overall system and analyzed to determine the ...
1985-11-01
Energy Technology Data Exchange (ETDEWEB)
This paper describes high speed rolling and gauge control in cold tandem mill for ultra-thin gauge strip at the Chiba Works of Kawasaki Steel Corporation. To improve the plate-out property of rolling oil, cationic polymeric coagulant was prepared. Rolling oil with cohesion independent of inorganic inclusions or phosphatide was developed, to improve the lubrication for cold rolling, remarkably. In addition, a low-cost Ti-enhanced work roll having high wear resistance and excellent grindability was developed. Rolling can be conducted at the optimal rolling roughness and operation can be performed at the highest rolling speed independent of the rolling treatment amount. Rolling speed at 2800 m/min was confirmed by developing the rolling oil with excellent lubrication and the work roll having high wear resistance. For the improvement of strip thickness accuracy at the steady state rolling, use of the backup roll as roller bearing was more effective ...
1996-09-01
Technical review, Vol. 29, No. 3, Ser. No. 85, October 1992
Energy Technology Data Exchange (ETDEWEB)
Contents: expansion of pc mill application to plate mill and tandem cold mill; application of cluster type rolling mill (cr mill) for rolling of special steel (illustration); development of on-line roll grinding system with profile meter; development of new type jet pickling; new technology in continuous annealing furnace (illustration); anti-seismic testing system by 3-dimensional shaking table; development of mitsubishi hybrid desulfurization system; field performance of 500 mw advanced coal fired supercritical pressure operation boiler for unit no. 1 of tsuruga thermal power station, hokuriku electric power co., inc.; development of electronically controlled cylinder liner lubrication system for marine diesel engines; prediction technology on steady-state and transient performance of multi-air conditioners; a knowledge-based system approach to the autonomous piloting and navigation control of ships.
1992-01-01
TPX Neutral Beam Injection System design
International Nuclear Information System (INIS)
The existing Tokamak Fusion Test Reactor Neutral Beam system is proposed to be modified for long pulse operation on the Tokamak Physics Experiment (TPX). Day one of TPX will call for one TFTR beamline modified for 1000 second pulse lengths oriented co-directional to the plasma current. The system design will be capable of accommodating an additional co-directional and a single counter directional beamline. For the TPX conceptual design, every attempt was made to use existing Neutral Beam hardware, plant facilities, auxiliary systems, service infrastructure, and control systems. This paper describes the moderate modifications required to the power systems, the ion sources, and the beam impinged surfaces of the ion dumps, the calorimeters, the various beam scrapers, and the neutralizers. Also described are the minimal modifications required to the vacuum, cryogenic, and gas systems and the major modification of replacing the beamline-torus duct in its entirety. Operational considerations ...
1993-10-11
British Library Electronic Table of Contents (United Kingdom)
Abstract A next generation material for surface passivation of crystalline Si is Al2O3. It has been shown that both thermal and plasma-assisted (PA) atomic layer deposition (ALD) Al2O3 provide an adequate level of surface passivation for both p- and n-type Si substrates. However, conventional time-resolved ALD is limited by its low deposition rate. Therefore, an experimental high-deposition-rate prototype ALD reactor based on the spatially separated ALD principle has been developed and Al2O3 deposition rates up to 1.2-nm/s have been demonstrated. In this work, the passivation quality and uniformity of the experimental spatially separated ALD Al2O3 films are evaluated and compared to conventional temporal ALD Al2O3, by use of quasi-steady-state photo-conductance (QSSPC) and carrier density ...
2011-01-01
Role of unsaturated soil in a waste containment system
Energy Technology Data Exchange (ETDEWEB)
The role of the unsaturated properties of sand as a drainage layer in a composite liner system for landfills is investigated. The effect of the unsaturated properties of coarse-grained soil on contaminant migration was evaluated by means of a series of simulations using a one-dimensional model of a two- and a three-layer soil liner system for advection and diffusion, respectively. The results showed that under seepage conditions, the effect of an unsaturated sand layer on the advancement of the concentration front was quite insignificant. The arrival time of the C/C{sub o} = 0.5 concentration front increased from 651 days for the case with no sand layer to approximately 951 days for the case with a 1.0-m sand layer. A steady-state flow condition was ultimately established in the sand, and this fact suggests that the capillary action might not be effective. For diffusion, the arrival time of the concentration front increased nonlinearly with a decrease in the degree ...
1996-12-31
Research on deformation characteristic of AZ31Mg alloy and its constitutive equations
Energy Technology Data Exchange (ETDEWEB)
Superplasticity of polycrystalline metallic materials is a phenomenon which shows hundreds to thousands of percents of large plastic deformation without necking in a steady state of low stress, when the uni-axial tensile loading is done in some special thermo-mechanical conditions (some limited ranges of properly high temperature and low strain rate). The main mechanism of superplastic phenomenon is the grain boundary sliding, while the main mechanism of usual plastic deformation is the trans-granular sliding. In this research, the possibility of superplastic deformation in a magnesium alloy (AZ31Mg alloy) was experimentally investigated, because generally speaking, the magnesium alloy whose atomic structure is hexagonal does not have enough formability in a form of trans-granular sliding mechanism. In this paper, the detail of experimental results are shown and discussed. Moreover, the constitutive equations of Mg alloy are proposed on the ...
2004-07-01
Energy Technology Data Exchange (ETDEWEB)
This paper describes an approach to the reliability engineering in aerospace technology. To promote development, configuration management (clarifies the base line of technology), reliability management, quality control, safety management, progress management, and cost management are very important. The following example related to reliability was contained for the development of an N-1 rocket in Japan. A timer and amplifier that are old-fashioned but have actual results were supplied from abroad. The induction system that was purchased from abroad contained faulty components in quality control. The improvement in reliability has priority and the first-stage tank was changed to a home-made aluminum alloy that is superior in stress-resistant corrosiveness. An H-II rocket was completely developed in Japan by self-technology. The number of faults to be generated in the H-II rocket decreases as compared with the N-1 rocket. In the combustion test of an H-II rocket`s first-stage main engine, ...
1995-02-05
Recent developments in the design of conceptual fusion reactors
International Nuclear Information System (INIS)
Since the first round of conceptual fusion reactor designs in 1973 - 1974, there has been considerable progress in design improvement. Two recent tokamak designs of the Wisconsin and Culham groups, with increased plasma beta and wall loading (power density), lead to more compact reactors with easier maintenance. The Reference Theta-Pinch Reactor has undergone considerable upgrading in the design of the first wall insulator and blanket. In addition, a conceptual homopolar energy storage and transfer system has been designed. In the case of the mirror reactor, there are design changes toward improved modular construction and ease of handling, as well as improved direct converters. Conceptual designs of toroidal-multiple-mirror, liner-compression, and reverse-field pinch reactors are also discussed. A design is presented of a toroidal multiple-mirror reactor that combines the advantages of steady-state operation and high-aspect ratio. The liner-compression reactor ...
Radon exhalation from uranium mill tailings: Modelisation and in situ validation
International Nuclear Information System (INIS)
TRACI, a model based on the physical mechanisms governing the radon transport in unsaturated soils, has been developed to evaluate the radon flux density at Uranium Mill Tailings (UMT) covers surface. First, moisture contents in the soil, induced by weather conditions, are calculated. Then, radon concentrations in the air-filled pore space, and radon flux density at the soil surface, are deduced from a transport model which takes account for diffusion and convection in the pore space. To check the hypothesis used in TRACI and the efficiency of cover layers, an in situ study was launched in 1997 with the French uranium mining company, COGEMA. It consists of continuous measurements of moisture contents, suctions, radon concentrations at various depths inside an UMT cover, and flux density at its surface. The first analysis made on in situ observations shows that radon concentrations and flux density, calculated with a steady-state diffusion model using monthly ...
2002-02-01
RESOLVING DOPPLER-FACTOR CRISIS IN ACTIVE GALACTIC NUCLEI: NON-STEADY MAGNETIZED OUTFLOWS
International Nuclear Information System (INIS)
Magnetically driven non-stationary acceleration of jets in active galactic nuclei results in the leading parts of the flow being accelerated to much higher Lorentz factors than in the case of steady-state acceleration with the same parameters. The higher Doppler-boosted parts of the flow may dominate the high-energy emission of blazar jets. We suggest that highly variable GeV and TeV emission in blazars is produced by the faster moving leading edges of highly magnetized non-stationary ejection blobs, while the radio data trace the slower-moving bulk flow. Thus, the radio and gamma-ray emission regions have different, but correlated, Doppler factors. High-energy emission is generated, typically within the optically thick core, in the outer parts of the broad-line emission region, avoiding the radiative drag on the faster parts of the flow. The radio emission should correlate with the gamma-ray emission, delayed with frequency-dependent time lag of the order of weeks ...
2010-10-10
Progress on fatigue characterization of ITER primary first wall mock-ups
International Nuclear Information System (INIS)
In 2001, EFDA has assigned to ENEA a contract for the thermomechanical testing of six mock-ups of the ITER primary wall module. These small scale mock-ups, reproducing representative portions of the reference ITER primary wall panels, were fabricated during ITER EDA phase by solid hot isostatic pressing (HIPping) of an AISI 316L stainless steel back structure to a alumina dispersion strengthened (DS)-Cu alloy heat sink armored with beryllium tiles. The experimental program, carried-out at ENEA Brasimone CEF 1-2 thermal hydraulic facility, was focused on the thermal mechanical testing of these mock-ups aiming at verifying which tile geometry and manufacturing procedure assures the required reliability of the beryllium/DS-Cu alloy/SS joints at high incident heat flux (>0.8 MW/m"2) both at steady state and under thermal fatigue tests. The paper presents the progress in the experimental activity of the first test campaign and the main ...
2003-09-01
Energy Technology Data Exchange (ETDEWEB)
The objective of this study is to develop an artificial neural network (ANN) model to predict the thermal conductivity of ethylene glycol-water solutions based on experimentally measured variables. The thermal conductivity of solutions at different concentrations and various temperatures was measured using the cylindrical cell method that physical properties of the solution are being determined fills the annular space between two concentric cylinders. During the experiment, heat flows in the radial direction outwards through the test liquid filled in the annual gap to cooling water. In the steady state, conduction inside the cell was described by the Fourier equation in cylindrical coordinates, with boundary conditions corresponding to heat transfer between the solution and cooling water. The performance of ANN was evaluated by a regression analysis between the predicted and the experimental values. The ANN predictions yield R{sup 2} in the ...
2009-10-15
Power system stabilizer application in a two unit plant analytical studies and field tests
Energy Technology Data Exchange (ETDEWEB)
The use of excitation system controls, specifically the Power System Stabilizer (PSS), to improve damping of power system oscillations and thus extend steady-state stability limits has been a subject of great interest in recent years. The desire to more fully utilize transmission capacity led to the installation of PSS controls on greater numbers of generating units to maintain stability margins. This paper addresses the tuning and adjustment of PSS controls in a two unit power plant. Both analytical studies and field test confirmations are presented. The practical difficulties of verifying the PSS control loop gain margin by testing are explored. A simplified procedure is outlined. The Lower Colorado River Authority (LCRA), Fayette Power Project (FPP) consists of two 683.7 MVA tandem compound steam turbine driven generators. The excitation systems are of the alternator rectifier type and the PSS control utilizes shaft speed as an input signal. The units must ...
1983-02-01
Energy Technology Data Exchange (ETDEWEB)
Transient experiments in a Temporal Analysis of Products (TAP) Reactor were performed to elucidate the role of surface oyxgen species in the oxidation of benzene to phenol on ZSM-5 type zeolites with nitrous oxide as a selective oxidant. It was shown by puls experiments with nitrous oxide that the mean lifetime of the generated surface oxygen species is between 0.2s at 500 C and about 4.2 s at 400 C. Afterwards the surface oxygen species desorb as molecular oxygen into the gas phase where total oxidation will take place if hydrocarbons are present. Dual puls experiments consisting of a nitrous oxide puls followed by a benzene puls allowed studying the reactivity of the surface oxygen species formed during the first puls. The observation of the phenol formation was impeded due to the strong sorption of phenol. Multipulse experiments were necessary to reach a pseudo steady state phenol yield. (orig.)
1998-12-31
Pharmacokinetics of multiple doses of valsartan in patients with heart failure.
Angiotensin II has adverse actions in heart failure including vasoconstriction, aldosterone secretion, and activation of the sympathetic nervous system. Valsartan, a potent specific angiotensin II type 1 receptor blocker, may produce beneficial effects in heart failure. The purpose of this study was to evaluate the steady-state pharmacokinetics of valsartan 40, 80, and 160 mg each given every 12 h for 7 days in heart failure patients. Eighteen patients with chronic stable heart failure and left ventricular ejection fractions power model, showed that doubling the dose increased the AUC and Cmax 1.8 times. The pharmacokinetics of valsartan are predictable in heart failure patients within the dose range of 40-160 mg BID. Age did not appear to have influenced the valsartan clearance in heart failure patients. The pharmacokinetic values were higher in heart failure patients than in healthy volunteers. All doses were generally safe and well tolerated.(max) (max) ...
2002-11-01
Energy Technology Data Exchange (ETDEWEB)
Two computational problems were worked on for this study. The first chapter examines the option of coal combustion using oxygen feed with carbon dioxide recycle to control the adiabatic flame temperature. Computer simulations using an existing state-of-the-art 3-dimensional computer code for turbulent reacting flows with reacting particles were employed to study the effects of increased carbon dioxide mole fraction on the char burnout, radiant heat transfer, metal partitioning, and NOx formation. The second chapter compares assumptions for the CO/CO{sub 2} ratio at the surface of mineral inclusions made in previous studies to predictions obtained from a pseudo-steady state kinetic model (SKIPPY) for a single porous particle. The detailed kinetic simulations from SKIPPY for varying particle sizes and bulk gas compositions were used to develop algebraic expressions for the CO/CO{sub 2} ratio that can be incorporated into metal vaporization ...
2002-02-28
Numerical simulation of droplets deposition in a horizontal turbulent channel flow
In this dissertation, a two-phase, air-droplets, dilute, turbulent, and steady state flow in a horizontal rectangular channel, is modeled and numerically simulated using a modified KIVA-3V code. The deposition of different sizes of droplets on the walls of the channel is also studied. In this model, the interaction effects between the phases (two-way coupling) are considered by source terms in the momentum and energy equations for the continuous phase and by the instantaneous local velocity of the air in the droplet equation of motion, which includes the aerodynamic and gravitational forces. The turbulence is modeled by a k-? model. The interaction effects between the turbulence and the dispersed droplets are also taken into account. The effects of the turbulence on the droplets are modeled by a fluctuating component added to the local air velocity in the droplet equation of motion. The effects of the droplets on the turbulence are modeled by ...
1999-01-01
Numerical Simulation of a Compartment Fire in a Nuclear Power Plant Containment Building
International Nuclear Information System (INIS)
The current trend towards the increased use of risk assessment in the regulation of nuclear power plants will inevitably result in changes in the analysis of fire protection systems and the methods of analysis. Before fire protection can be regulated on a risk basis, a consensus must be reached on a number of issues. One key issue is what types of computational tools will be allowable for analyzing fire events, and what types of scenarios those tools will be approved for use. Reaching this consensus will require an understanding of the types of computational tools available and their inherent advantages and disadvantages. To aid with this understanding, three different methods of fire simulation are applied to an oil pool fire test in the HDR (Heiss Dampf Reaktor) containment test facility. These methods are a hand calculation, the zone model code CFAST (Consolidated Model of Fire Growth and Smoke Transport), and the computational fluid dynamics code FDS (Fire Dynamics Simulator). Each ...
2002-04-14
Natural circulation in FFTF, a loop type LMFBR
International Nuclear Information System (INIS)
The authors present a state-of-the-art review of natural circulation heat transfer in loop type reactor plants. Most of the examples are taken from Fast Flux Test Facility (FFTF) design experience, drawing on the authors' familiarity and a developing base of available documentation. On-going studies related to the Clinch River Breeder Reactor (CRBR) and some foreign experience are also noted where available in the literature. The emphasis is on the role of natural circulation in decay heat removal; however, free convection during either operation at power or normal shutdown does influence some aspects of the design and these are reviewed. In treating decay heat removal the topics discussed include steady state loop performance and transient dynamics for conditions immediately after scram and for the longer term which involves different considerations. The review summarizes complex dynamics, specific to the FFTF design evaluation, which ...
Molina: a non-linear code to compute the internal hydrodynamics of a gas centrifuge
Energy Technology Data Exchange (ETDEWEB)
Uranium enrichment by gas centrifugation relies on the pressure diffusion of the isotopes when their gaseous mixture is submitted to the pressure diffusion in the strong radial pressure gradient due to the centrifugal force in a very rapidly rotating cylinder. To compute the isotope separation in a gas centrifuge, the viscous compressible Navier-Stokes equations are solved for the mixture, then the diffusion equations are solved for the isotopes. As far as the separation performance is concerned, the models deal with the steady state of the axi-symmetric gas motion in the rotating cylinder. The numerical tools are briefly presented: first, the MOLINA code which numerically solves the axi-symmetric gas motion in the specific conditions of rapid rotation by use of a change of variables suited to the high density gradient and by use of a Marker And Cell method; then, the diffusion equations solver which uses a Finite Volume method with a mesh ...
2003-07-01
Materials needs for compact fusion reactors
Energy Technology Data Exchange (ETDEWEB)
The economic prospects for magnetic fusion energy can be dramatically improved if for the same total power output the fusion neutron first-wall (FW) loading and the system power density can be increased by factors of 3 to 5 and 10 to 30, respectively. A number of compact fusion reactor embodiments have been proposed, all of which would operate with increased FW loadings, would use thin (0.5 to 0.6 m) blankets, and would confine quasi-steady-state plasma with resistive, water-cooled copper or aluminum coils. Increased system power density (5 to 15 MWt/m/sup 3/ versus 0.3 to 0.5 MW/m/sup 3/), considerably reduced physical size of the fusion power core (FPC), and appreciably reduced economic leverage exerted by the FPC and associated physics result. The unique materials requirements anticipated for these compact reactors are outlined against the well documented backdrop provided by similar needs for the mainline approaches. Surprisingly, no single materials need that ...
1983-01-01
Liquid zone system events at Wolsong Unit 2
International Nuclear Information System (INIS)
On June 19, 1998, after the first annual outage, Wolsung Unit 2 was shutdown at a controlled rate due to the continuous instability of Liquid Zone Control level. Investigation revealed that the Liquid Zone Control level instability was caused by water condensed inside the helium lines, generated from the moistened helium flow, especially, inside the helium balance header feed and bleed valve lines. It was found that improper installation of the diaphragm type isolation valves and the drain valve tap could easily contain the water inside the lines and be destined to form water traps causing the balance header pressure oscillation. After the lines were dried, Liquid Zone Control level instability was almost vanished, and approached the allowable equilibrium state. As the reactor power was increased, however, the zone level instability increased again. In order to compensate for the excessive, the Bulk Power Control Gain (Kp) was reduced to provide a more stable ...
1998-09-07
Energy Technology Data Exchange (ETDEWEB)
Geological, geophysical, thermal, petrophysical and hydrological data available for the East Mesa hydrothermal system that are pertinent to the construction of a computer model of the natural flow of heat and fluid mass within the system are assembled and correlated. A conceptual model of the full system is developed and a subregion selected for quantitative modeling. By invoking the Boussinesq approximation, valid for describing the natural flow of heat and mass in a liquid hydrothermal system, it is found practical to carry computer simulations far enough in time to ensure that steady-state conditions are obtained. Initial calculations for an axisymmetric model approximating the system demonstrate that the vertical formation permeability of the deep East Mesa system must be very low (k/sub v/ approx. 0.25 to 0.5 md). Since subsurface temperature and surface heat flow data exhibit major deviations from the axisymmetric approximation, exploratory three-dimensional ...
1982-01-01
In-pile measurements of fuel rod deformation and verification of the finite element model FEMAXI
International Nuclear Information System (INIS)
For safety evaluations and licensing procedures, fuel rod performance is predicted through model calculations. Due to the complexity of fuel rod performance and the insufficient availability of experimental data, such calculations necessarily reflect inaccuracies and conservatism. For verification and development of more realistic models and submodels, acquisition of reliable on-line data on fuel rod performance characteristics is imperative. The present paper describes the instruments and equipment applied in the Halden Reactor for on-line measurements of fuel rod and assembly power and power distribution, and fuel rod axial and diameter deformation. Recent results from evaluation of such fuel rod deformation measurements, covering fuel rods with different designs, subjected to various modes of operation, including startup ramps, steady state, and power shock, are presented. It is also shown how these data are used for verification and ...
1976-09-13
Energy Technology Data Exchange (ETDEWEB)
Increasingly stringent pollution regulations have spurred a broad interest in the reduction of engine emissions. Two strategies can be considered: after-treatment or engine emissions reduction. For Diesel engines, after-treatment has a high cost induced by the required technology and implementation issues. In this context, the Highly Premixed Combustion combustion mode (HP C) has emerged as a topic of major interest in recent years. It represents one of the most promising ways for new generation of CI engines using high Exhaust Gas Recirculation (EGR) rates. Experimentation on the test bench brought the proof of significant emission reduction. However, actual vehicle implementation implies frequent transient which fall far beyond steady state experimentation on the test bench. Several key challenges have to be addressed. With this combustion technology; accurate torque balancing at all engine modes is a requirement. Even slight unbalance ...
2006-07-01
High Order Finite Volume Nonlinear Schemes for the Boltzmann Transport Equation
Energy Technology Data Exchange (ETDEWEB)
The authors apply the nonlinear WENO (Weighted Essentially Nonoscillatory) scheme to the spatial discretization of the Boltzmann Transport Equation modeling linear particle transport. The method is a finite volume scheme which ensures not only conservation, but also provides for a more natural handling of boundary conditions, material properties and source terms, as well as an easier parallel implementation and post processing. It is nonlinear in the sense that the stencil depends on the solution at each time step or iteration level. By biasing the gradient calculation towards the stencil with smaller derivatives, the scheme eliminates the Gibb's phenomenon with oscillations of size O(1) and reduces them to O(h{sup r}), where h is the mesh size and r is the order of accuracy. The current implementation is three-dimensional, generalized for unequally spaced meshes, fully parallelized, and up to fifth order accurate (WENO5) in space. For unsteady problems, the resulting ...
2005-03-29
Energy Technology Data Exchange (ETDEWEB)
Substantial thermal performance improvement in ice-on-tube cold thermal energy storage systems (TES) is possible by making use of porous copper mesh as a Heat Conducting Enhancement Device (HCED). HCEDs are inexpensive heat transfer augmentation devices that can result in faster rate of ice growth and larger final steady state ice build volume by reducing the controlling thermal conduction resistance of the ice layer. This improves the competitiveness of external ice-on-tube systems as compared to other TES systems, such as dynamic ice harvesters and static internal melt systems. In this study the amount of ice growth enhancement is predicted theoretically, by performing simplified 1-D calculations, and is then validated in the laboratory through carefully controlled experiments. This study shows that ice volume increase between 50 and 90% is possible by using HCEDs of the type tested. (author)
2006-09-15
Gyrokinetic particle simulation model
Energy Technology Data Exchange (ETDEWEB)
A new type of particle simulation model based on the gyrophase-averaged Vlasov and Poisson equations is presented. The reduced system, in which particle gyrations are removed from the equations of motion while the finite Larmor radius effects are still preserved, is most suitable for studying low frequency microinstabilities in magnetized plasmas. It is feasible to simulate an elongated system (L/sub parallel/ >> L/sub perpendicular/) with a three-dimensional grid using the present model without resorting to the usual mode expansion technique, since there is essentially no restriction on the size of ..delta..x/sub parallel/ in a gyrokinetic plasma. The new approach also enables us to further separate the time and spatial scales of the simulation from those associated with global transport through the use of multiple spatial scale expansion. Thus, the model can be a very efficient tool for studying anomalous transport problems related to steady-state ...
1986-07-01
Flow regime transition criteria for upward two-phase flow in vertical tubes
Energy Technology Data Exchange (ETDEWEB)
Traditional two-phase flow-regime criteria based on the gas and liquid superficial velocities may not be suitable to the analyses of rapid transient or entrance flows by the two-fluid model. Under these conditions, it is postulated that direct geometrical parameters such as the void fraction are conceptually simpler and therefore more reliable parameters to be used in flow-regime criteria than the traditional parameters. From this point of view, new flow-regime criteria for upward gas-liquid flow in vertical tubes have been developed considering the mechanisms of flow-regime transitions. These new criteria can be compared to existing criteria and experimental data under steady-state and fully developed flow conditions by using relative velocity correlations. The criteria showed reasonable agreements with the existing data for atmospheric air-water flows. Further comparisons with data for steam-water in round tubes and a rectangular channel at relatively high system ...
1984-05-01
Flow regime transition criteria for upward two-phase flow in vertical tubes
International Nuclear Information System (INIS)
Traditional two-phase flow-regime criteria based on the gas and liquid superficial velocities may not be suitable to the analyses of rapid transient or entrance flows by the two-fluid model. Under these conditions, it is postulated that direct geometrical parameters such as the void fraction are conceptually simpler and therefore more reliable parameters to be used in flow-regime criteria than the traditional parameters. From this point of view, new flow-regime criteria for upward gas-liquid flow in vertical tubes have been developed considering the mechanisms of flow-regime transitions. These new criteria can be compared to existing criteria and experimental data under steady-state and fully developed flow conditions by using relative velocity correlations. The criteria showed reasonable agreements with the existing data for atmospheric air-water flows. Further comparisons with data for steam-water in round tubes and a rectangular channel at relatively high system ...
1984-01-01
Energy Technology Data Exchange (ETDEWEB)
The thermal contact resistance between balls and inner and outer rings of thermally steady space-use deep groove ball bearings was studied experimentally to verify the validity of the previously proposed calculation method for the resistance. The 440C stainless steel single row bearing was used for measuring its steady state temperature distributions in a vacuum environment under axial, radial and combined load conditions. As a result, the experimental results of the resistance well agreed with calculated ones under each load condition resulting in the sufficient validity at nearly the same surface roughness. It was necessary to apply a static equivalent radial load to calculation under the combined load that a contact angle is larger than the angle of resultant force dependent on both load components. In experiments under only radial load, measurement of outer ring temperatures was necessary at some points with no contact with balls to avoid ...
1992-12-05
Energy Technology Data Exchange (ETDEWEB)
As a series of experimental determinations of the thermal diffusivity of molten alkali halides, this paper describes measurements on five molten alkali metal chlorides (LiCl, NaCl, KCl, RbCl, and CsCl) in the temperature range up to 1440 K by the forced Rayleigh scattering method. K[sub 2]Cr[sub 2]O[sub 7] is employed as a dye substance to color the transparent molten salts. In comparison with the present results converted into thermal conductivity, most of the previous experimental data obtained by steady-state methods show larger values, up to about five times, which may be due to the systematic error caused by the presence of convection and radiation. It is found that the thermal conductivity of these series of molten alkali metal chlorides decreases with increasing molecular weight, and their temperature coefficients are weakly negative. 24 refs., 9 figs., 6 tabs.
1992-07-01
International Nuclear Information System (INIS)
A series of experimental measurements of the yield of O_3 in nuclear-induced O_2 and O_2-SF_6 discharges are reported. The discharges were created by bombardment with energetic particles from the "1"0B(n,#alpha#)"7Li reaction. Continuous irradiation at dose rates of 10"1"5--10"1"7 eV cm"-"3 s"-"1 and pulsed irradiation (--10 ms FWHM) at a peak dose rate of --10"2"0 eV cm"-"3 s"-"1 were conducted. At the lower dose rates, the addition of SF_6 generally increased the ozone yield due to the slowing of ozone destruction by negative oxygen and ozone ions. In contrast, at the high dose rates, the ozone concentration decreased due to SF_6 suppression of atomic oxygen formation by ion--ion recombination. A numerical model was developed and tested against experimental conditions. This model indicates that the steady-state ozone concentration was limited by the reaction O"-_3+O_3#->#2O_2+O"-_2 with a rate coefficient of --1 x 10"-"1"2 cm"3 s"-"1. In addition to dose rate ...
Experimental Electron Heat Diffusion in TJ-II ECRH Plasmas
Energy Technology Data Exchange (ETDEWEB)
Interpretative transport has been used to revisit the global scalings of TJ-II ECRH plasmas from a local perspective. Density, rotational transform and ERCH power scans were analysed based upon Thomson Scattering data (electron density and temperature) in steady state discharges. A simple formula to obtain the thermal conductivity, assuming pure diffusion and negligible convective heat fluxes was used in a set of 161 discharges. All the analysis was performed with the ASTRA transport shell. The density scan indicates that inside n=0,4 there is no significant change of e with density in the range studied (0.4 <ne>(1019m-3) 1.0), while in 0,5 <0,8 approximately, e decreases with density. In the rotational transform scan it is found that the values of e when a low order rational of the rotational transform is present locally seem to be smaller for the corresponding range, although it is apparent a general beneficial effect of ...
2006-07-01
International Nuclear Information System (INIS)
The Swedish State Power Board has together with Nukem, Hanau, West-Germany carried out pyrolysis o powder resins in a pilot plant with a capacity of about 30 kg/hr. The pyrolysis reactor with its afterburner and offgas scrubber system has been operated under steady state condition. About 2200 kg resins have been pyrolysed under November-December 1983 and the decontamination factor for Cs has been measured. Solidification of the residues from the pyrolysis reactor and scrubber water solutions has been carried out and various recipes with cement have been tested. The pyrolysis process has high decontamination factors and no offgas problems as the operating temperature of the reactor is Low. The residues from the reactor are chemically dead and can not cause swelling problems. Compared with a normal cementation process the final waste volume will be reduced with a factor of 4 if also the scrubber water after neutralization is solidified. The ...
Exhaust emissions from a Diesel engine fueled with transesterified waste olive oil
Energy Technology Data Exchange (ETDEWEB)
The exhaust emissions of a Diesel direct injection Perkins engine fueled with waste olive oil methyl ester were studied at several steady-state operating conditions. Emissions were characterized with neat biodiesel from used olive oil and conventional Diesel fuel. Results revealed that the use of biodiesel resulted in lower emissions of CO (up to 58.9%), CO{sub 2} (up to 8.6%, excepting a case which presented a 7.4% increase), NO (up to 37.5%), and SO{sub 2} (up to 57.7%), with increase in emissions of NO{sub 2} (up to 81%, excepting a case which presented a slight reduction). Biodiesel also presented a slight increase in brake-specific fuel consumption (lower than 8.5%) that may be tolerated due to the exhaust emission benefits. Combustion efficiency remained constant using either biodiesel or Diesel fuel. The proposed alternative for Diesel fuel could significantly decrease the enormous amount of waste frying oil, furthermore becoming less dependent on fossil oil ...
2003-07-01
Efficient modeling for pulsed activation in inertial fusion energy reactors
International Nuclear Information System (INIS)
First structural wall material (FSW) materials in inertial fusion energy (IFE) power reactors will be irradiated under typical repetition rates of 1-10 Hz, for an operation time as long as the total reactor lifetime. The main objective of the present work is to determine whether a continuous-pulsed (CP) approach can be an efficient method in modeling the pulsed activation process for operating conditions of FSW materials. The accuracy and practicability of this method was investigated both analytically and (for reaction/decay chains of two and three nuclides) by computational simulation. It was found that CP modeling is an accurate and practical method for calculating the neutron-activation of FSW materials. Its use is recommended instead of the equivalent steady-state method or the exact pulsed modeling. Moreover, the applicability of this method to components of an IFE power plant subject to repetition rates lower than those of the FSW is still being studied. The ...
2000-11-01
Energy Technology Data Exchange (ETDEWEB)
An Allis-Chalmers, Model 2900, turbocharged diesel engine was converted to a dual-fuel engine in which ethyl alcohol was fumigated between the turbocharger and the intake manifold, and the diesel fuel was injected normally at a reduced rate. Tests were performed to determine if crankcase oil dilution that had occurred was caused by the following independent parameters: proof of the ethyl alcohol, crankcase oil temperature, engine load at maximum torque speed, and percentage of total energy in the form of ethyl alcohol. Engine tests were steady state for six hours, after which the crankcase oil was sampled for American Society for Testing and Materials (ASTM) laboratory tests for determination of flash points and fire points, water by centrifuge, water by distillation, and viscosity at room temperature. Results indicate a decrease in thermal efficiency and an increase in exhaust carbon monoxide as the percentage of total energy as alcohol is ...
1982-11-01
Energy Technology Data Exchange (ETDEWEB)
The effect of raising the rate of photosynthesis on the allocation of carbon between sucrose and starch was studied by means of steady-state radiolabeling. Sugar beet source leaves on intact plants were exposed to ambient levels of CO{sub 2} and O{sub 2} for 3 hrs. Next CO{sub 2} was raised to 600 {mu}LL{sup {minus}3} for 3 hrs then O{sub 2} was decreased to 2% for 3 hrs. Rates of net carbon exchange (NCE), export, and starch and sucrose synthesis were measured. NCER increased by 30% under the combined treatments and the proportion of photosynthate allocated to starch and to sucrose did not change. When O{sub 2} concentration was lowered, NCER increased but export did not and sucrose accumulated. This observation, and our earlier conclusion that export rate usually equals sucrose synthesis rate, lead us to conclude that low O{sub 2} directly inhibited export. Low O{sub 2} treatment causes sucrose to accumulate in a sugar beet leaf which usually accumulates little ...
1990-05-01
International Nuclear Information System (INIS)
A study has been performed of the initial corrosion of support structure alloys in crevices of various geometries, when galvanically coupled to alloy 600. Corrosion rates were monitored continuously by measuring the galvanic current flowing in each couple, transduced by a zero impedance ammeter. Experiments were performed in a single-pass flowing electrolyte system, with AVT water pumped through alloy 600 tubing past the orifice of each crevice. Fourteen crevices were studied simultaneously in two parallel flow arms containing seven specimens each. The steady state AVT water pH/hydrazine/oxygen concentrations were controlled by microcomputer, allowing the effect of secondary water chemistry on the corrosion rate to be studied easily. Control of the crevice electrolyte composition was achieved by separately pumping electrolyte, at a low rate, directly into the crevices of the seven specimens in the lower flow arm. In addition, a high pressure ...
1985-03-01
Energy Technology Data Exchange (ETDEWEB)
The leakage current behaviors of PLZT capacitors with top electrodes of Pt, Ir, and IrO{sub 2} are investigated before and after hydrogen forming gas anneal. The P-E hysteresis and fatigue properties of Pt/PLZT/Pt capacitors are almost recovered after recovery anneal in O{sub 2} ambient. The leakage current mechanisms of PLZT capacitors with Pt and IrO{sub 2} top electrodes are consistent with space-charge influenced injection model showing the strong time dependence irrespective of annealing conditions. On the other hand, the leakage current behavior of Ir/PLZT/Pt capacitor shows steady state independent of time because IrPb, conducting phase, formed at interface between Ir top and PLZT is a high conduction path. Teh leakage current mechanism of Ir/PLZT/Pt capacitor is consistent with Schottky barrier model. (author). 15 refs., 6 figs.
2001-02-01
Development and validation of steam generator models for thermal performance monitoring
International Nuclear Information System (INIS)
The thermal performance monitoring and optimization system TEMPO is developed at the OECD Halden Reactor Project. The system supports staff of nuclear power plants in identification and correction of problems, which cause small decreases in plant efficiency but which may lead to significant economical losses. The system-wide physical model consists of mathematical description of individual components, such as the reactor, the pumps, the heat exchangers, or the turbines, etc. TEMPO code has recently been extended with new steam generator (SG) models. The present paper summarizes the thermal-hydraulic modelling aspects of the vertical and the horizontal SG. The heat balance equations and their solution are shown with the appropriate initial and boundary conditions. The method of the calculation of the pressure losses are also introduced. The vertical SG model is based on a U-tube structure and treated as a 1D flow channel. The horizontal approach is a superposition of individually ...
2003-04-20
International Nuclear Information System (INIS)
The steady state surfaces of ion bombarded 3C-, 4H- and 6H-SiC samples were studied by means of reflected electron energy loss spectroscopy (REELS). The REELS exhibit a well-defined loss peak in the region of about 20 eV. The position of the maximum of the loss peak depends on the bombarding ion energy (decreasing with increasing ion energy), and on the primary electron beam energy (increasing with increasing primary energy). This behavior can be explained if we suppose that the plasmon energy in the altered layer (produced by ion bombardment) is different from that of the unaltered bulk. In this case the measured loss peak is the sum of two overlapping plasmon peaks. With modeling the system as a homogeneous altered layer and a homogeneous unaltered substrate the plasmon energy in the altered layer was derived to be 19.8 eV. The large change of the plasmon energy with respect to the bulk value of 23 eV is explained by a thin low density ...
2005-12-15
Cyclopropane isomerization over Eu[sup 3+]NaX zeolites
Energy Technology Data Exchange (ETDEWEB)
Cyclopropane isomerization to propylene over various Eu[sup 3+] loadings in NaX zeolite have been studied by measurements of steady-state and transient kinetics and by Fourier transform infrared spectroscopy. As Eu[sup 3+] loading increases, the rate of deactivation increases, the conversion increases, apparent activation energies are lowered, and Bronsted acid site strength and amounts increase. Apparent activation energies of 13-15 kcal/mol for propylene formation have been observed for these systems, consistent with literature reports for other metal supported heterogeneous catalyst systems. Deactivation studies have shown that activity can be restored by heating in He at 380[degrees]C between various temperature runs, and that gases desorbed during regeneration are predominantly propylene. Poisoning studies of Bronsted sites with Na vapor lead to deactivation of these catalysts. A reaction mechanism scheme based on [pi] allyl intermediates in the supercages of ...
1992-11-01
Energy Technology Data Exchange (ETDEWEB)
In supervising CANDU plant operation, Operations staff must routinely monitor plant status using information from several information systems. One key source of plant status information are the CRT displays at console workstations and panel locations. At Darlington, as at most CANDU plants, Operations staff have adopted a reference set of displays for use in monitoring during Full Power Steady State conditions. The display set employed was chosen from the available suite of displays, and operational experience has demonstrated that the current displays could be improved. For Outages, no reference display set has been defined, and for Upset conditions, the current Transient display set does not provide the information needed by operations staff, and consequently is not used. This paper describes the basis for and findings from a COG project [1] undertaken in 1997 to characterize monitoring practice and develop improvements to control room ...
1999-07-01
International Nuclear Information System (INIS)
Plasma triglyceride turnover was measured during steady-state conditions in 22 postoperative patients. Nine had received nutritional support with an enteral regimen, seven had received an equivalent regimen as continuous parenteral nutrition, and six received the same parenteral regimen as a cyclical infusion. After 5 days of nutritional support, each patient received an intravenous bolus of tritiated glycerol. Plasma radiolabeled triglyceride content was measured during the subsequent 24 hours. The data were analyzed by means of a simple deterministic model of plasma triglyceride kinetics and compared with the results obtained by stochastic analysis. The rates of hepatic triglyceride secretion obtained by deterministic analysis were higher than those obtained by the stochastic approach. However, the mode of delivery of the nutritional regimen did not affect the rate of hepatic triglyceride secretion regardless of the method of analysis. The results suggest that ...
Combustion of olive husks in a small scale BFB facility for heat and steam generation
Energy Technology Data Exchange (ETDEWEB)
The paper reports a work-in-progress outlook of a R and D project aimed at developing an advanced boiler for the combustion of virgin and exhaust olive husks at small scale. Fluidized bed technology has been preferred because of its well known advantages that include large thermal inertia, high combustion efficiency, low NOx emissions and considerable heat transfer rate. A 100 kW atmospheric bubbling fluidized bed combustor has been designed and built. The facility is equipped with devices for continuous fuel feeding as well as heat extraction from the bed region. Measurements of temperature and gas concentrations are obtained by using thermocouples and gas-analyzer. Steady state tests of combustion were carried out at typical fluidized bed combustion temperatures. Tests proved that not only exhaust olive husks but also the virgin ones - with a water content larger than 50% by mass - can be reliably fed onto the fluidized bed. Further, they ...
2000-07-01
Characteristics of volatile fatty acid decomposition in anaerobic fluidized bed
Energy Technology Data Exchange (ETDEWEB)
The growth kinetics constants and concentration of active attached biomass in an anaerobic fluidized bed which decomposes acetic, propionic and butyric acid were estimated. The mixture of above mentioned fatty acids was supplied to the fluidized bed in the range of hydraulic retention time (HRT) from 0.25 to 2 days. After the effluent reached in a steady state in quality, batch experiments were conducted separately with each fatty acid as a substrate in order to investigate the decomposition characteristics of each substrate by attached biomass. In order to estimate the parameter values of the growth kinetics of the bacteria, batch experiments were also conducted under the completely mixed condition using detached biomass from a support material. The changes of fatty acid concentrations with time were clearly expressed with the Monod growth model. Maximum specific substrate decomposition rates and saturation constants, and active biomass ...
1988-06-01
Energy Technology Data Exchange (ETDEWEB)
The rate coefficients for the reactions of OH radical with CH3Br and CH2Br2 were measured as functions of temperature using the laser photolysis - laser induced fluorescence method. This data was incorporated into a semiempirical model (Solomon et al., 1992) and a 2D model to calculate the steady-state ozone depletion potentials (ODP) and atmospheri lifetimes, tau, with greatly improved accuracy as compared to earlier studies. The calculated ODPs and tau are 0.65 and 1.7 years and 0.17 and 0.41 years for CH3Br and CH2Br2, respectively, using the semiempirical model. These lifetimes agree well with those calculated using a 2D model. This study better quantifies the ODPs and tau of these species which are needed inputs for discussion of possible regulation of human emissions currently under international considerations. 29 refs.
1992-10-01
Energy Technology Data Exchange (ETDEWEB)
A one-way coupling system between the plant simulator TRAC/BF1-ENTREE and the subchannel code with the improved cross flow model, NASCA, has been developed. Based on a scenario of turbine trip tests in the Peach Bottom Unit 2, the wide and rapid reactivity insertion transient induced by the system pressure rise was calculated. The pin power distribution in hot bundles was re-constructed considering heterogeneity of the fuel bundle. When the neighboring control blade is withdrawn, NASCA predicted that the steady-state bundle exit void distribution was nearly flat with regardless of the pin power distribution. However, void distributions in the middle and lower bundle regions became complicated depending on the pin power and the two-phase flow regime in each subchannel. The pin power distribution rapidly changed according to traveling of control blades. However, influence in the void distribution was delayed and damped due to the fuel heat conduction. The detailed ...
2002-11-01
Energy Technology Data Exchange (ETDEWEB)
Mathematical tools are needed to screen out sites where Joule-Thomson cooling is a prohibitive factor for CO{sub 2} geo-sequestration and to design approaches to mitigate the effect. In this paper, a simple analytical solution is developed by invoking steady-state flow and constant thermophysical properties. The analytical solution allows fast evaluation of spatiotemporal temperature fields, resulting from constant-rate CO{sub 2} injection. The applicability of the analytical solution is demonstrated by comparison with non-isothermal simulation results from the reservoir simulator TOUGH2. Analysis confirms that for an injection rate of 3 kg s{sup -1} (0.1 MT yr{sup -1}) into moderately warm (>40 C) and permeable formations (>10{sup -14} m{sup 2} (10 mD)), JTC is unlikely to be a problem for initial reservoir pressures as low as 2 MPa (290 psi).
2010-05-21
International Nuclear Information System (INIS)
The 3D modeling of the thermal hydraulic processes and soluble impurity distribution in the horizontal steam generator PGV-1000 was fulfilled with the thermal hydraulic code STEG. Steady-state operation of horizontal seam generator PGV-1000 was analyzed at nominal power. The modeling of the soluble impurity distribution was fulfilled on the basis of the previous thermal hydraulic modeling results. The processes of the soluble impurity deposition on the steam generator tube bundles and deposits outwash were considered in the mathematical model of the code. The modeling was fulfilled for horizontal steam generators with different peculiarities in construction. Calculation results were compared with experimental results obtained at NPP. The agreement between calculated and experimental results is quite reasonable. Results of modeling are sensible to the peculiarities of the horizontal steam generator construction and consideration of these peculiarities in calculation ...
2003-04-20
Analysis of the VVER-440 reactor steam generator secondary side with the RELAP5/MOD3 code
Energy Technology Data Exchange (ETDEWEB)
Nuclear Engineering Laboratory of the Technical Research Centre of Finland has widely used RELAP5/MOD2 and -MOD3 codes to simulate horizontal steam generators. Several models have been developed and successfully used in the VVER-safety analysis. Nevertheless, the models developed have included only rather few nodes in the steam generator secondary side. The secondary side has normally been divided into about 10 to 15 nodes. Since the secondary side at the steam generators of VVER-440 type reactors consists of a rather large water pool, these models were only roughly capable to predict secondary side flows. The paper describes an attempt to use RELAP5/MOD3 code to predict secondary side flows in a steam generator of a VVER-440 reactor. A 2D/3D model has been developed using RELAP5/MOD3 codes cross-flow junctions. The model includes 90 volumes on the steam generator secondary side. The model has been used to calculate steady state flow conditions ...
1993-12-31
Analysis of the VVER-440 reactor steam generator secondary side with the RELAP5/MOD3 code
International Nuclear Information System (INIS)
Nuclear Engineering Laboratory of the Technical Research Centre of Finland has widely used RELAP5/MOD2 and -MOD3 codes to simulate horizontal steam generators. Several models have been developed and successfully used in the VVER-safety analysis. Nevertheless, the models developed have included only rather few nodes in the steam generator secondary side. The secondary side has normally been divided into about 10 to 15 nodes. Since the secondary side at the steam generators of VVER-440 type reactors consists of a rather large water pool, these models were only roughly capable to predict secondary side flows. The paper describes an attempt to use RELAP5/MOD3 code to predict secondary side flows in a steam generator of a VVER-440 reactor. A 2D/3D model has been developed using RELAP5/MOD3 codes cross-flow junctions. The model includes 90 volumes on the steam generator secondary side. The model has been used to calculate steady state flow conditions ...
1992-09-29
An investigation into flow regimes for two-phase helium flow
Energy Technology Data Exchange (ETDEWEB)
The Tevatron accelerator at Fermilab incorporates long two-phase helium passages. During magnet design, the generalized flow map of Baker was used to predict homogeneous flow. Longer than expected magnet time constants led to this investigation. The importance of predicting the flow regime has been amplified with the advent of non-horizontal accelerator designs. A test setup was constructed at Fermilab to investigate two-phase helium flow regimes for conditions practical in accelerator designs. The setup consisted of a standard Tevatron satellite refrigerator, subcooling dewar, heater, 35 m long transfer line, and a specialized end box. A knife blade on the midplane of the transfer line diverted the flow from the upper and lower halves of the pipe to separate vessels in the end box. The amount of liquid above and below the plane was measured at various total mass flow rates and liquid percentages. The results show that stratified flow occurs at much higher liquid percentages than ...
1987-10-01
A few papers have been interested by the fixed switching frequency direct torque control fed by direct matrix converters, where we can find just the use of direct torque controlled space vector modulated method. In this present paper, we present an improved method used for a fixed switching frequency direct torque control (DTC) using a direct matrix converter (DMC). This method is characterized by a simple structure, a fixed switching frequency which causes minimal torque ripple and a unity input power factor. Using this strategy, we combine the direct matrix converters advantages with those of direct torque control (DTC) schemes. The used technique for constant frequency is combined with the input current space vector to create the switching table of direct matrix converter (DMC). Simulation results clearly demonstrate a better dynamic and steady state performances of the proposed method.
2010-01-01
Energy Technology Data Exchange (ETDEWEB)
The computer programme COMMIX-2 describes steady state and transient multidimensional single- and two-phase fluid flows with heat transfer in nuclear reactor components and multicomponent systems. Originally from the Argonne National Laboratory, the code has been further developed at the Kernforschungszentrum Karlsruhe. The original Point-SOR iterative method for the solution of a Poisson-like equation describing the pressure distribution in the fluid as well as the transport of enthalpy and turbulent quantities has been complemented with iterative and direct line- and block-methods. None of the newly implemented methods is original in itself but their implementation into the computer code, which can describe the most general shapes of definition domains, gave a code speed-up by a factor of 2-5, depending on the problem treated. The code capabilities are assessd by the calculation of a benchmark problem involving the numerical simulation of ...
1987-03-01
International Nuclear Information System (INIS)
The computer programme COMMIX-2 describes steady state and transient multidimensional single- and two-phase fluid flows with heat transfer in nuclear reactor components and multicomponent systems. Originally from the Argonne National Laboratory, the code has been further developed at the Kernforschungszentrum Karlsruhe. The original Point-SOR iterative method for the solution of a Poisson-like equation describing the pressure distribution in the fluid as well as the transport of enthalpy and turbulent quantities has been complemented with iterative and direct line- and block-methods. None of the newly implemented methods is original in itself but their implementation into the computer code, which can describe the most general shapes of definition domains, gave a code speed-up by a factor of 2-5, depending on the problem treated. The code capabilities are assessd by the calculation of a benchmark problem involving the numerical simulation of ...
1987-01-01
DEFF Research Database (Denmark)
The aim of the present study was to test a mathematical model of the biochemical processes in the parathyroid glands responsible for the secretion of parathyroid hormone resulting from extracellular calcium reduction. A double exponential curve described the parathyroid hormone secretion induced by rapid lowering of blood-ionized calcium in humans with normal as well as abnormal parathyroid tissue. Our data show that it was possible to establish a simple mathematical model of the parathyroid hormone response to blood-ionized calcium lowering, sufficient to fit experimental data obtained from patients with abnormal and normal parathyroid tissue. The fitted parameters showed no significant differences between patients with insulin-dependent diabetes mellitus and controls. In primary hyperparathyroidism, the parathyroid hormone production and steady-state transport across the cell membrane were increased, probably due to the larger amount of parathyroid tissue in ...
1997-01-01
International Nuclear Information System (INIS)
Analysis of steady-state and transient photoconductivity measurements at room temperature performed on c-axis oriented GaN nanowires yielded estimates of free carrier concentration, drift mobility, surface band bending, and surface capture coefficient for electrons. Samples grown (unintentionally n-type) by nitrogen-plasma-assisted molecular beam epitaxy primarily from two separate growth runs were examined. The results revealed carrier concentration in the range of (3-6)x10"1"6 cm"-"3 for one growth run, roughly 5x10"1"4-1x10"1"5 cm"-"3 for the second, and drift mobility in the range of 500-700 cm"2/(V s) for both. Nanowires were dispersed onto insulating substrates and contacted forming single-wire, two-terminal structures with typical electrode gaps of #approx =#3-5 #mu#m. When biased at 1 V bias and illuminated at 360 nm (3.6 mW/cm"2) the thinner (#approx =#100 nm diameter) nanowires with the higher background doping showed an abrupt increase in photocurrent ...
2010-02-01
Energy Technology Data Exchange (ETDEWEB)
A heat pump was tested in the cooling mode under the following conditions: (1) a steady-state test with 95/sup 0/F (35/sup 0/C) outdoor temperature, various indoor conditions, and a dry indoor coil; (2) a steady-state test with 82/sup 0/F (27.8/sup 0/C) outdoor temperature, various indoor conditions, and a dry indoor coil; (3) a cyclic test with an outdoor room temperature of 82/sup 0/F (27.8/sup 0/C), various indoor conditions, and a dry indoor coil. The indoor conditions were varied as follows: (1) indoor temperatures of 75/sup 0/F (23.9/sup 0/C), 80/sup 0/F (26.7/sup 0/C) and 85/sup 0/F (29.4/sup 0/C); (2) volume flowrates over the evaporator coil of 880 cfm (0.47 m/sup 3//s), 1100 cfm (0.52 m/sup 3//s) and 1425 cfm (0.67 m/sup 3//s); (3) during the off-time the dampers were closed in one test series and kept open with a continuously running air handling fan in another test series; (4) the on and off times of the heat pump during the cyclic ...
1982-05-01
In the past few decades the need for improved nuclear reactor safety analyses has led to a rapid development of advanced methods for multidimensional thermal-hydraulic analyses. These methods have become progressively more complex in order to account for the many physical phenomena anticipated during steady state and transient Light Water Reactor (LWR) conditions. The advanced thermal-hydraulic subchannel code COBRA-TF (Thurgood, M. J. et al., 1983) is used worldwide for best-estimate evaluations of the nuclear reactor safety margins. In the framework of a joint research project between the Pennsylvania State University (PSU) and AREVA NP GmbH, the theoretical models and numerics of COBRA-TF have been improved. Under the name F-COBRA-TF, the code has been subjected to an extensive verification and validation program and has been applied to variety of LWR steady state and transient simulations. To enable ...
2007-01-01
Differential effects of chronic ingestion of tritiated water on prenatal brain development
International Nuclear Information System (INIS)
Female rats were given tritiated drinking water (3 microCi/ml) from 30 days before mating up to and throughout pregnancy. At this low dose, the course and the outcome of pregnancy were normal. The differences between newborn body and cerebral weights of the treated rats and those of control animals were on the borderline of significance. In contrast, cerebral DNA and cerebral protein were highly significantly lower. In 30-35% of the treated population the DNA and protein values were more than 2 standard deviations (SD) below the mean values for the control population. Thus the number of the progeny of the mothers exposed to tritiated water that were considered to have outstandingly low levels of DNA and protein was 14-17 times greater than in the control group. The irradiated population also had 3-5% of severely affected individuals with cerebral DNA and protein values more than 2 SD below the mean of ...
International Nuclear Information System (INIS)
The present study sought a biochemical explanation for retarded brain development in the heterozygous offspring of the phenylketonuric (PKU) mother. Two rat models of simulated maternal PKU, one induced by p-chloropheylalanine and phenylalanine and the other by phenylacetate, were employed in this investigation. Maternal PKU had no influence on cerebral concentrations of DNA, protein, and cholesterol, which were normal in the 2 d old pup. However, there was a noticeable disruption of the normal ganglioside pattern and a significant reduction of sialoglycoproteins. Concomitant with a delayed drop in the gangliosides Q/sub 1b/ and D_3, was a slower rise in M_1 and D/sub 1a/. At least 66% of sialoglycoproteins located on SDS-PAGE gel chromatograms, by radioactivity incorporated in vivo from radiolabeled N-acetylmannosamine and by ("3H) sialic acid released by neuraminidase from periodate-("3H) borohydride labeled glycoproteins, have mobilites of the cell adhesion ...
Brain development during the first year of life. Quantitative assessment with ADC imaging
International Nuclear Information System (INIS)
Brain development during the first year of life was assessed quantitatively using apparent diffusion coefficient (ADC) images constructed from diffusion-weighted MR image data. The imaging plane was coronal at the section of the pons. The cerebral peduncle, internal capsule, corona radiata, superior longitudinal fasciculus and thalamus were selected for evaluation of their ADC values. A diffusion sensitive gradient was added in the anteroposterior direction. Thus the orientation of nerve fibers in the cerebral peduncle, internal capsule and corona radiata was perpendicular to it, and that in the superior longitudinal fasciculus was parallel to it. In neonates, the cerebral peduncle and internal capsule, having been moderately myelinated at birth, showed the slowest diffusion. The corona radiata and superior longitudinal fasciculus, having been unmyelinated at birth, showed the fastest diffusion. The thalamus had ...
Energy Technology Data Exchange (ETDEWEB)
The role of high-resolution computed tomography (HRCT) and magnetic resonance imaging (MRI) in the diagnosis of preoperative and postoperative complications caused by acquired cholesteatomas will be described in this paper. The pre- and postoperative imaging of the temporal bone was performed with HRCT and MRI. HRCT and MRI were performed in the axial and coronal plane. MRI was done with T2 weighted and T1 weighted sequences both before and after the intravenous application of contrast material. All imaging findings were confirmed clinically or surgically. The preoperative cholesteatoma-caused complications depicted by HRCT included bony erosions of the ossicles, scutum, facial canal in the middle ear, tympanic walls including the tegmen tympani, and of the labyrinth. The preoperative cholesteatoma-caused complications depicted by MRI included signs indicative for labyrinthitis, and brain abscess. Postoperative HRCT ...
2003-03-01
Energy Technology Data Exchange (ETDEWEB)
Purpose: The purpose of this study was to observe the process of fixation in liver specimens non-invasively by means of magnetic resonance. The fixation process of several formaldehyde-containing solutions was monitored with MRI and MRS at two different temperatures. Materials and Methods: Liver specimens were conserved in aqueous fixative solutions containing formaldehyde concentrations of 0.7, 1.8, 4 and 7.2% and at different temperatures of 5 C and 20 C. MRI was performed with T1-, T2- and PD-weighted TSE sequences, a 2D FLASH-sequence with and without magnetization transfer, and a FISP 3D-sequence on a clinical 1.5 Tesla MR whole-body unit, and MRS with {sup 1}H-spectroscopic methods (STEAM-sequence) on a 3 Tesla MR whole-body unit. Results: The diffusion of formaldehyde into the tissue was best identified on PD- and T1-weighted images as a band under the liver surface with increasing thickness, penetrating especially ...
2004-04-01
Diagnosis of plasmocytomas using magnetic resonance imaging; Diagnostik des Plasmozytoms mit der MRT
Energy Technology Data Exchange (ETDEWEB)
Background. In multiple myeloma 5 different infiltration patterns can be differentiated: 1. Normal appearance of bone marrow, 2. focal involvement, 3. homogeneous diffuse infiltration, 4. combined diffuse and focal infiltration, 5. 'salt-and pepper' pattern with inhomogeneous bone marrow with interposition of fat islands. Methods. For the fast and total acquisition of all patterns a combination of a T1-weighted spin echo sequence and a fat suppression technique is superior. The focal involvement is clearly demonstrated as areas of high signal intensity on e.g. STIR images. Diffuse involvement can be quantified objectively by calculation of the percentage of signal intensity increase after contrast material injection. MRI is superior to X-ray in focal and diffuse involvement. With ultrafast sequences a 'screening' of the whole red bone marrow as for myeloma infiltration is possible. ...
2000-08-01
British Library Electronic Table of Contents (United Kingdom)
Translating experimental findings into clinically effective therapies is one of the major bottlenecks of modern medicine. As this has been particularly true for cerebrovascular research, attention has turned to the quality and validity of experimental cerebrovascular studies. We set out to assess the study design, statistical analyses, and reporting of cerebrovascular research. We assessed all original articles published in the Journal of Cerebral Blood Flow and Metabolism during the year 2008 against a checklist designed to capture the key attributes relating to study design, statistical analyses, and reporting. A total of 156 original publications were included (animal, in vitro, human). Few studies reported a primary research hypothesis, statement of purpose, or measures to safeguard in...
2011-01-01
Energy Technology Data Exchange (ETDEWEB)
A noninvasive method is described for estimating local cerebral blood flow (LCBF) and local partition coefficients by means of computed tomographic scanning during inhalation of 30% stable xenon gas in oxygen. Time-dependent xenon concentrations in arterial blood and brain tissue during the wash-in and washout phases are used to calculate partition coefficients and LCBF values by means of a least-squares curve-fitting analysis. Control values for partition coefficient and LCBF obtained from control subjects with minor head trauma in the chronic stage were compatible with those in several past reports, and reproducibility was satisfactory. The theoretic grounds underlying this new method of curve-fitting analysis are discussed.
1988-07-01
International Nuclear Information System (INIS)
A noninvasive method is described for estimating local cerebral blood flow (LCBF) and local partition coefficients by means of computed tomographic scanning during inhalation of 30% stable xenon gas in oxygen. Time-dependent xenon concentrations in arterial blood and brain tissue during the wash-in and washout phases are used to calculate partition coefficients and LCBF values by means of a least-squares curve-fitting analysis. Control values for partition coefficient and LCBF obtained from control subjects with minor head trauma in the chronic stage were compatible with those in several past reports, and reproducibility was satisfactory. The theoretic grounds underlying this new method of curve-fitting analysis are discussed.
Volumetric quantification of brain development using MRI
International Nuclear Information System (INIS)
We devised a three-dimensional method for estimation of cerebral development and myelination which measures cerebral volume using MRI. Accuracy of the system was estimated using cadaver brains. The mean percentage error in the calculated volumes compared with the real volumes was 2.33 %, range 0.00-5.33 %. We applied the method to the volume of both cerebral hemispheres (CH), basal ganglia, thalamus and internal capsule (BT), and myelinated white matter (WM) in 44 neurologically normal individuals (4 months to 28 years of age), 13 patients with spastic motor disturbances (2-25 years of age), and 9 patients with athetotic motor disturbances (2-23 years of age). In the neurologically normal cases, the volumes of CH, BT and WM increased with age; the volume of MW more slowly than that of CH. In cases with spastic motor disturbances, the volumes of CH, BT and WM were between -1.4 and 3.5 SD, -1.0 and -3.5 SD, and 0.0 and -5.2 ...
Radioiodide uptake in brain, CSF, thyroid, and salivary glands of audiogenic seizure mice
Energy Technology Data Exchange (ETDEWEB)
DBA/2J (DBA) mice are susceptible to audiogenic seizures (ASs) in an age-dependent manner. Anion transport as measured by radioiodide uptake was determined in thyroid gland, salivary gland, skeletal muscle, cerebral cortex, cerebellum, brainstem, and CSF from these mice at various ages. Anion transport was also determined in C57BL/6J(C57) mice, an AS-resistant strain. In thyroid, DBA mice had an enhanced ability to concentrate iodide at 21 days of age when they have maximal AS susceptibility, as compared with the same-aged C57 mice. This difference in thyroid function was less marked at 40 days of age, when DBA mice are less AS susceptible, and was absent at 110 days of age, when DBA mice are AS resistant. In brain, differences in iodide uptake were also noted between these two strains of mice at 21 days of age. DBA mice had an increased concentration of iodide in CSF, an indication that they have a defect in the transport of iodide out of the CSF across the ...
1984-08-01
Non-selective cervical and cerebral three-dimensional rotational angiography
International Nuclear Information System (INIS)
To evaluate the usefulness of three-dimensional (3D) rotational angiography, cervical carotid or cerebral angiography was done without catheterizing the branches of the thoracic aorta. A 5-Fr pig-tail type catheter was passed into the ascending aorta via the radial artery or the femoral artery. Optimal carotid angiogram views were obtained using approximately 45 ml of contrast medium at a flow rate of 15 ml/sec. Optimal cerebral angiogram views were obtained using approximately 70 ml of contrast medium at a flow rate of 20 ml/sec. The contrast medium concentration was 300 to 350 mgI/ml. A satisfactory view could be obtained in 5 of 8 (63%) cases on cervical carotid 3D angiography and in 8 of 14 (57%) cases on cerebral 3D angiography. In all cases, no complications were noted. This method offers the advantages of requiring a relatively short procedure time and a decrease in radiation exposure. Further studies are needed to ...
2007-09-01
Energy Technology Data Exchange (ETDEWEB)
Iodixanol is a new nonionic dimer, isotonic with blood at all clinically relevant concentrations. Iodixanol (270 mg I/ml) was compared in a double-blind, randomized, parallel-group, phase-III study to the monomeric nonionic iohexol (300 mg I/ml) for evaluation of safety, tolerability and radiographic efficacy during cerebral CT. One hundred adult patients scheduled to undergo contrast-enhanced cerebral CT were randomly allocated to receive either iodixanol or iohexol. All completed the trial. Safety was evaluated by recording discomfort and other adverse events, tolerance by assessing intensity and incidence of discomfort. Radiographic efficacy was assessed from the diagnostic information and the radiographic density. No serious adverse events occurred. One patient (2 %) in the iodixanol group and one patient (2 %) in the iohexol group experienced a transient reddening at the neck and lower neck-line, respectively. Both contrast agents were ...
1999-09-01
Energy Technology Data Exchange (ETDEWEB)
This study was designed to evaluate early parenchymal changes of acute cerebral is chemia/infarct by using T2-weighted, diffusion-weighted, and calculated apparent diffusion coefficient(ADC) MR imaging. The brain MR images were successfully obtained 30, 60, 90, 120, 150 and 180 minutes after intraarterial administration of Lipiodol (0.4-0.6ml) into the common carotid artery in 10 of 11 cats (91%). T2-and diffusion-weighted images and ADC were analyzed and compared with histopathologic findings. High signal intensity on T2-weighted and diffusion-weighted images was found in one cerebral hemisphere 30 minutes after Lipiodol injection, which tended to increase with time until 3 hours. Subcortical white matter showed higher signal intensity than cortical gray matter since 30 minutes after embolization. ADC images showed decreased signal intensity in the embolized hemisphere, which tended to decrease until 3 hours. Microscopic findings of the area ...
1997-06-01
Cerebral sparganosis. Case report.
The tapeworm Spirometra mansonoides infects man worldwide, particularly in Asian countries. Rarely, the central nervous system is involved; such a case is presented here. In the total of 12 reported cases, including the case described, the worm presented clinically as a mass suspicious for neoplasm or chronic abscess cavity. Surgical removal was invariably curative in each case. Although infrequent, the possibility of tapeworm infection should be entertained in the evaluation of intracranial masses in patients who have visited exotic locales. PMID:2191089
1990-07-01
CO_2 reactivity and heterogeneity of cerebral blood flow in ischemic, border zone, and normal cortex
International Nuclear Information System (INIS)
Regional arterial CO2 tension (PaCO2) reactivity of cerebral blood flow (CBF) and the effect of PaCO2 on the spatial and temporal heterogeneity of CBF were investigated by using autoradiographically determined CBF in the rat middle cerebral artery occlusion model after a 2-h period under pentobarbital anesthesia to clarify the relation between PaCO2 reactivity, CBF heterogeneity, and the temporal cycling of CBF. PaCO2 was adjusted to one of four levels. CBF was determined in four cortical areas and white matter using the tissue fractionation of [14C]iodoantipyrine [( 14C]IAP) in combination with vessel mapping using in vivo 4% thioflavine S. Specific PaCO2 reactivity and CBF were normal in the nonischemic cortex, normal, although slightly depressed, in the border zone far from the ischemic core area, and depressed in the border zone adjacent to the ischemic core area (P less than 0.001) and the ischemic core (P less than 0.001). In normocapnic ...
UK PubMed Central (United Kingdom)
The neocortex plays a critical role in the gradual formation and storage of remote declarative memories. Because the circuitry mechanisms of systems-level consolidation are not well understood, the...Full Text Available
Prior to 1978, the Wilsonville Advanced Coal Liquefaction facility material balance surrounded only the thermal liquefaction unit and involved analyses of only the slurry stream and individual gas streams. The distillate solvent yield was determined by difference. Subsequently, several modifications and additional process units were introduced to this single unit system. With the inclusion of the deashing unit in 1978 and the catalytic hydrogenation unit in 1981, the process has evolved into a sophisticated two-stage coal liquefaction process and has the potential for various modes of integration. This report presents an elemental balancing procedure and a simplified presentation format that is sufficiently flexible to meet current and future needs. The development of the elemental balancing technique and the relevant computer programs to handle the calculations have been addressed. This will be useful in modelling individual unit performance as well as determining the impact of each ...
1984-09-01
Upgrading Athabasca tar sand using toe-to-heel air injection
Energy Technology Data Exchange (ETDEWEB)
A new air injection process called toe-to-heel air injection (THAI) has been developed to achieve very stable combustion performance in heavy oil wells by controlling gas override. In the THAI process, injected air migrates preferentially to the combustion front into a horizontal producer well by the oxygen diffusional gradient created under steady state conditions. This is possible because of the balance between the stoichiometric oxygen flux needed to burn the fuel (coke) laid down ahead of the combustion front and the removal of downstream combustion gases and mobilised fluids. This study involved a numerical simulation of the THAI process to increase the understanding of the processes involving fluid flow, heat transfer and chemical reactions taking place during in situ combustion. Two tests were conducted involving one dry and one wet combustion using heavy Wolf Lake Oil. The objective was to determine if the behaviour of the oil could be ...
2000-11-01
Transition armature technology. Progress report No. 2, August 1--September 30, 1991
Energy Technology Data Exchange (ETDEWEB)
This second report covers the period August 1 to September 30, 1991. During this period we modified our approach to Task 1 (Hybrid Armature study) with the addition of a numerical simulation of the steady state plasma brush length with a 1-D, four-phase equation of state code. A test fixture was designed and fabrication begun on a plasma brush test fixture for hybrid studies. It will be powered by a 140 kJ, 1 MA capacitor bank on loan to the project. Diagnostic data collection with 20 channels of digitizers and data reduction with a microvax were also arranged. Sliding friction of a solid armature was simulated and found to form a vapor layer at velocities below 2 km/s. The simulations indicated that higher interface pressure results in vapor boundary layer formation at lower velocity. If there is also a minimum interface pressure required to commutate high currents, then an optimum interface pressure will probably result. Plans for a launcher ...
1991-12-31
The US Advanced Liquid Metal Reactor and the Fast Flux Test Facility Phase IIA passive safety tests
International Nuclear Information System (INIS)
This report discusses the safety approach of the Advanced Liquid Metal reactor program, sponsored by the US Department of Energy, which relies upon passive reactor responses to off-normal condition to limit power and temperature excursions to levels that allow safety margins. Gas expansion modules (GEM) have included in the design to provide negative reactivity to enhance these margins in the extremely unlikely event that pumping power is lost and the highly reliable scram system fails to operate. The feasibility and beneficial features of these devices were first demonstrated in the core of the Fast Flux Test Facility (FFTF) in 1986. Preapplication safety evaluations by the US Nuclear Regulatory Commission have identified areas that must be addressed if these devices are to be relied on. One of these areas is the response of the reactor when it is critical and the pumps are turned on, resulting in positive reactivity being added to the core. Tests to examine such transients have been ...
1992-10-25
International Nuclear Information System (INIS)
The safety approach of the Advanced Liquid Metal Reactor program, sponsored by the U.S. Department of Energy, relies upon passive reactor responses to off-normal conditions to limit power and temperature excursions to levels that allow large safety margins. Gas expansion modules (GEM) have been included in the design to provide negative reactivity to enhance these margins in the extremely unlikely event that pumping power is lost and the highly reliable scram system fails to operate. The feasibility and beneficial features of these devices were first demonstrated in the core of the Fast Flux Test Facility (FFTF) in 1986. Pre-application safety evaluations by the U.S. Nuclear Regulatory Commission have identified areas that must be addressed if these devices are to be relied on. One of these areas is the response of the reactor when it is critical and the pumps are turned on, resulting in positive reactivity being added to the core. Tests to examine such transients have been performed ...
TRIGA spent fuel bundles safe storage
International Nuclear Information System (INIS)
TRIGA-SSR is a steady state research and material test reactor that has been in operation since 1980. The original TRIGA fuel was HEU (highly enriched uranium) with a U"2"3"5 enrichment of 93 per cent. Almost all TRIGA HEU fuel bundles are now burned-up. Part of the spent fuel was loaded and transferred to US, in a Romania - DOE arrangement. The rest of the TRIGA fuel bundles have to be temporarily stored in the TRIGA facility. As the storage conditions had to be established with caution, neutron and thermal hydraulic evaluations of the storage conditions were required. Some criticality evaluations were made based on the SAR (Safety Analysis Report) data. Fuel constant axial temperature approximation effect is usual for criticality computations. TRIGA-SSR fuel bundle geometry and materials model for SCALE5-CSAS module allows the introduction of a fuel temperature dependency for the entire fuel active height, using different materials for each ...
2007-05-13
Energy Technology Data Exchange (ETDEWEB)
This paper describes the modeling of horizontal steam generator with the TRACE code and calculation results of a loss-of-feedwater (LOF-10) experiment at the PACTEL facility. Parallel Channel Test Loop (PACTEL) is an integral test facility for a VVER-440 type nuclear reactor. The main objectives were to prepare a simulation model for its horizontal steam generator with the TRACE thermal hydraulic code and assess different modeling options of the code. PACTEL experiment LOF-10 was chosen for this assessment. The calculation results showed that TRACE is capable in simulating horizontal steam generator behavior both in steady state and during loss-of-feedwater transient. The phenomenon of heat transfer from primary to secondary side, steam superheating and flow reversal in the lowest heat exchange tubes were studied in detail. Different nodalization options were introduced. In the simulation of PACTEL loss-of-feedwater experiment LOF-10, the main ...
2010-11-15
International Nuclear Information System (INIS)
This paper describes the modeling of horizontal steam generator with the TRACE code and calculation results of a loss-of-feedwater (LOF-10) experiment at the PACTEL facility. Parallel Channel Test Loop (PACTEL) is an integral test facility for a VVER-440 type nuclear reactor. The main objectives were to prepare a simulation model for its horizontal steam generator with the TRACE thermal hydraulic code and assess different modeling options of the code. PACTEL experiment LOF-10 was chosen for this assessment. The calculation results showed that TRACE is capable in simulating horizontal steam generator behavior both in steady state and during loss-of-feedwater transient. The phenomenon of heat transfer from primary to secondary side, steam superheating and flow reversal in the lowest heat exchange tubes were studied in detail. Different nodalization options were introduced. In the simulation of PACTEL loss-of-feedwater experiment LOF-10, the main ...
2010-11-01
Swelling behavior of a simple ferritic alloy
International Nuclear Information System (INIS)
The swelling behavior which results from simulated fusion environment irradiation of Fe-10% Cr has been characterized with transmission electron microscopy. Specimens were bombarded at 850 K with: a ''triple-beam'' of He"+, D_2"+, and 4 MeV Fe"+"+ ions to 0.3, 1, 3, 10, 30, and 100 dpa (displacement per atom); a ''dual-beam'' of He"+ and 4 MeV Fe"+"+ ions to 30 and 100 dpa; and a ''single-beam'' of 4 MeV Fe"+"+ ions to 30 dpa. The helium and hydrogen injection rates were approx. =10 appm He/dpa and approx. =40 appm D/dpa. Cavities were observed for damage levels of 3 dpa and greater. The swelling was <0.1% for damage levels <30 dpa, but at 100 dpa, there was an increase in the swelling to 2.5% for the ''triple-beam'' irradiation and 1.2% for the ''dual-beam'' irradiation. The swelling rates between 30 and 100 dpa correlate well with calculated values assuming a steady-state swelling-rate regime has been reached. Calculations show the rapid cavity growth ...
Studies on current distribution in electrochemical cells
Energy Technology Data Exchange (ETDEWEB)
Three studies of electrochemical current distribution have been performed using potential-theory models and the boundary-element method (BEM). (1) The steady-state behavior of cells with nonuniform current density over a passivating anode is investigated. Current distributions calculated for a test cell, using the measured kinetic behavior of nickel in acid-nickel-sulfate solution, are compared to estimates from earlier models. Although current-density profiles determined by weight loss on a segmented rotating cylinder agreed satisfactorily with model calculations, the measured length of the passive zone exceeds the theoretical value. The model's applicability to anodic protection is demonstrated for a stainless-steel sulfuric-acid holding tank. (2) A model is established to describe the effects of attached bubbles on the potential drop at gas-evolving electrodes including: (1) ohmic obstruction within the electrolyte; (2) area masking on the electrode ...
1986-08-01
Energy Technology Data Exchange (ETDEWEB)
The stoichiometry of photorespiration, S, is defined as the fraction of glycolate carbon photorespired. It is postulated that under steady-state conditions there are two determinants of the ratio of photorespiration to net photosynthesis: the partitioning of ribulose bisphosphate between oxidation and carboxylation, and the partitioning of glycolate between reactions leading to complete oxidation to CO/sub 2/ (S . 100%) and those yielding CO/sub 2/ plus serine (S . 25%). S may be calculated using two independent probes of the system. The physical probe, using an infrared gas analyzer, measured photorespiration and net photosynthesis, and hence their ratio PR/NPS . pn(phys). The metabolic probe employed tracer (3R)-D-(3-/sup 3/H1,3-/sup 14/C)glyceric acid to determine r, the fraction of /sup 3/H retained in the triose phosphates leaving the chloroplasts. It is deduced from the postulated model that S . pn(phys) . r/(1 - r). Experiments have been performed with ...
1985-03-01
Energy Technology Data Exchange (ETDEWEB)
The design of separation devices, particularly for solvent-based selective removal of H{sub 2}S from CO{sub 2}, requires an accurate mathematical model. Unfortunately, this requirement for high accuracy is often in conflict with the need for efficient computation. The addition of more and more complicated analyses, such as a move from Henry's law to a method incorporating gas and liquid activities for computing vapor liquid equilibria, may give a more accurate solution, but only at the cost of decreased computational efficiency. The efforts in this work have been directed toward two goals. The first was to develop an accurate mathematical model for the aqueous methyldiethanolamine (MDEA) system. The steady-state packed column model developed in this work has been tested with data from Schubert (1988) to verify its accuracy. The second goal was to modify the model to improve its computational efficiency. Areas such as vapor-liquid equilibrium calculations, ...
1988-01-01
Endothelial dysfunction and increased platelet aggregation may be involved in the pathogenesis of normal tissue radiation toxicity. This study assessed clopidogrel, an inhibitor of ADP-induced platelet aggregation, as a modulator of intestinal radiation injury (radiation enteropathy). Rat small intestine was exposed to 21 Gy X-radiation. Clopidogrel (20 mg/kg/day) or vehicle was administered from 2 days before to 10 days after irradiation. Structural radiation injury, neutrophil infiltration, smooth muscle cell proliferation, collagen content, and TGF-beta1 expression were assessed 2 weeks (early phase) and 26 weeks (delayed phase) after irradiation, using quantitative histology and immunohistochemistry, morphometry, and real-time fluorogenic probe RT-PCR. Irradiated intestine exhibited significant histopathologic injury, reduced mucosal surface area, vascular sclerosis, intestinal wall fibrosis, increased collagen content, and increased TGF-beta1 expression. Clopidogrel reduced ...
2002-01-01
Shell Temperatures for a Single-Heater Diffuser
Energy Technology Data Exchange (ETDEWEB)
A new diffuser/permeator design has been proposed for a new Savannah River Site tritium project. The use of a single heater well in the center of the shell had raised concerns that the Pd/Ag coils may be shielding radiative heat transfer to the walls thus reducing Pd/Ag tube temperatures near the shell below the recommended minimum operating temperature. The diffuser was fitted with thermocouples to measure shell temperatures during testing. Tests were run with the shell evacuated, helium feed flows of 0, 1000, and 2000 sccm; bleed pressures ranging from 0 to 203 kPa, and heater temperatures of 650, 675, and 700 degrees C. Hydrogen permeation tests were run with two hydrogen/helium mixtures and feed rates to simulate 1st and 2nd stage diffuser operations. Approximately 20 hours were required to bring the diffuser from ambient temperature to steady-state conditions. For tests with a heater temperature of 675 degrees C and no hydrogen flow, helium flow rate and ...
2004-11-01
Second-law analyses applied to internal combustion engines operation
Energy Technology Data Exchange (ETDEWEB)
This paper surveys the publications available in the literature concerning the application of the second-law of thermodynamics to internal combustion engines. The availability (exergy) balance equations of the engine cylinder and subsystems are reviewed in detail providing also relations concerning the definition of state properties, chemical availability, flow and fuel availability, and dead state. Special attention is given to identification and quantification of second-law efficiencies and the irreversibilities of various processes and subsystems. The latter being particularly important since they are not identified in traditional first-law analysis. In identifying these processes and subsystems, the main differences between second- and first-law analyses are also highlighted. A detailed reference is made to the findings of various researchers in the field over the last 40 years concerning all types of internal combustion engines, i.e. spark ignition, compression ignition (direct or ...
2006-07-01
Sandia LSI accelerated aging and data acquisition techniques
Energy Technology Data Exchange (ETDEWEB)
The purpose of the Microelectronic Evaluation Laboratory at Sandia is to develop a program for evaluating CMOS LSI (complementary metal oxide silicon - large scale integrated) technology devices which are being used for the first time in a weapon system. These evaluations are based on accelerated aging studies and electrical tests to determine the reliability and life of the devices. In accelerated aging, specific, controlled stresses are applied to the device to accelerate time-to-failure. Data are used tin mathematical models to estimate life in acutal use. The stresses used for this technology are temperature and voltage. The devices are stored at temperatures with or without voltage applied (steady-state or cyclical) and periodically tested until at least 50% failures are encountered. Since most current technologies use epoxy-die-attachment, aging temperatures must be under 200/sup 0/C. This delays device failure, and a 16% failure level is used when this ...
1980-04-01
Energy Technology Data Exchange (ETDEWEB)
This document is a user`s manual for the Rn3D finite element code. Rn3D was developed to simulate gas flow and radon transport in variably saturated, nonisothermal porous media. The Rn3D model is applicable to a wide range of problems involving radon transport in soil because it can simulate either steady-state or transient flow and transport in one-, two- or three-dimensions (including radially symmetric two-dimensional problems). The porous materials may be heterogeneous and anisotropic. This manual describes all pertinent mathematics related to the governing, boundary, and constitutive equations of the model, as well as the development of the finite element equations used in the code. Instructions are given for constructing Rn3D input files and executing the code, as well as a description of all output files generated by the code. Five verification problems are given that test various aspects of code operation, complete with example input files, FORTRAN programs ...
1994-01-01
Radionuclide release from irradiated Th-Pu mox fuel
International Nuclear Information System (INIS)
Plutonium and minor actinides produced as by-products of the UO_2 nuclear cycle could be considered as waste or energy source depending on the strategy selected in the nuclear energy programme. Considering Pu and Minor Actinides as a source, they can be burned in existing water reactor for diminishing the radiotoxicity of the spent fuel, it is necessary to use 'inactive' materials as matrix like ThO_2. ThO_2 matrix has demonstrated its Pu burning efficiency and higher corrosion resistance than UO_2. Uranium-plutonium mixed oxide (MOX) fuel efficiency is low because the presence of U in MOX results in the creation of some new Pu under irradiation. The dissolution behaviour of irradiated (Th,Pu)O_2 pellets with burn-up of 38.8 MWd/kg Th has been studied in carbonated (20 mM HCO_3"-), deionised and granite ground water solution in a hot cell. The dissolution behaviour of Th, Pu, U and Np was studied in order to find out whether radionuclides release is depending on the matrix dissolution ...
International Nuclear Information System (INIS)
Purpose: To quantify left ventricular function derived from retrospectively ECG-gated multislice spiral CT (MSCT) data sets in comparison to MRI. Materials and Methods: In 16 patients (14 males, 2 females, mean age 56.8 #+-# 11.5 years), retrospectively ECG-gated MSCT angiography of the coronary arteries and breath-hold steady state free precession cine MRI were performed. From MSCT data-sets, 20 axial image series were reconstructed every 5% of the RR interval. Multiplanar images were reformatted in the short axis orientation from axial images. End-systolic and end-diastolic images were selected. From these images end-systolic volume (ESV), end-diastolic volume (EDV) and stroke volume (SV) as well as the ejection fraction (EF) and myocardial mass (MM) were determined using the Simpson's method and compared with MRI. Furthermore, image quality was assessed for both imaging modalities using a four point grading scale. Results: All parameters ...
2003-01-01
Progress toward an optimized hydrogen series hybrid engine
Energy Technology Data Exchange (ETDEWEB)
The design considerations and computational fluid dynamics (CFD) modeling of a high efficiency, low emissions, hydrogen-fueled engine for use as the prime mover of a series hybrid automobile is described. The series hybrid automobile uses the engine to generate electrical energy via a lightweight generator, the electrical energy is stored in a power peaking device (like a flywheel or ultracapacitor) and used as required to meet the tractive drive requirements (plus accessory loads) through an electrical motor. The engine/generator is stopped whenever the energy storage device is fully charged. Engine power output required was determined with a vehicle simulation code to be 15 to 20 kW steady state with peak output of 40 to 45 kW for hill climb. Combustion chamber and engine geometry were determined from a critical review of the hydrogen engine experiments in the literature combined with a simplified global engine model. Two different engine ...
1995-06-01
Plasma neutralization models for intense ion beam transport in plasma
Energy Technology Data Exchange (ETDEWEB)
Plasma neutralization of an intense ion pulse is of interest for many applications, including plasma lenses, heavy ion fusion, cosmic ray propagation, etc. An analytical electron fluid model has been developed based on the assumption of long charge bunches (l{sub b} >> r{sub b}). Theoretical predictions are compared with the results of calculations utilizing a particle-in-cell (PIC) code. The cold electron fluid results agree well with the PIC simulations for ion beam propagation through a background plasma. The analytical predictions for the degree of ion beam charge and current neutralization also agree well with the results of the numerical simulations. The model predicts very good charge neutralization (>99%) during quasi-steady-state propagation, provided the beam pulse duration {tau}{sub b} is much longer than the electron plasma period 2{pi}/{omega}{sub p}, where {omega}{sub p} = (4{pi}e{sup 2}n{sub p}/m){sup 1/2} is the electron plasma ...
2003-05-01
Oxygen and hydrogen behavior in PWR primary circuits
Energy Technology Data Exchange (ETDEWEB)
PWR primary circuit radiolysis model describes oxygen/hydrogen behavior in the Westinghouse Sizewell B 4-loop PWR (SNUPPS design). The effect of oxygen ingress have also been evaluated using the same model. There is clear agreement from experimental and modelling data that the dissolved hydrogen concentration required to suppress radiolysis decreases as the temperature increases. There is good evidence from the study at the Belleville PWR that {approx}5 cc(STP)kg{sup -1} H{sub 2} is sufficient to suppress radiolysis during power operation. Modelling indicates that the minimum hydrogen concentration is about 0.5 cc (STP)kg{sup -1} at PWR operating temperatures and that the presence of boric acid has little effect on this value, although it does increase the steady-state concentration of H{sub 2}O{sub 2}. Downstream of the core the concentrations of both oxygen and hydrogen peroxide fall by about two orders of magnitude at full power due to reaction with radicals ...
1998-12-31
Numerical study of natural convection in fully open tilted cavities
Energy Technology Data Exchange (ETDEWEB)
A numerical simulation of two-dimensional laminar natural convection in a fully open tilted square cavity with an isothermally heated back wall is conducted. The remaining two walls of the cavity are adiabatic. Steady-state solutions are presented for Grashof numbers between 10{sup 2} and 10{sup 5} and for tilt angles ranging from {minus}60{degree} to 90{degree} (where 90{degree} represents a cavity with the opening facing down). The fluid properties are assumed to be constant except for the density variation with temperature that gives rise to the buoyancy forces, which is treated by the Boussinesq approximation. The fluid concerned is air with Prandtl number fixed at 0.71. The governing equations are expressed in a normalized primitive variables formulation. Numerical predictions of the velocity and temperature fields are obtained using the finite-volume-based power law (SIMPLER: Semi-Implicit Method for Pressure-Linked Equations Revised) algorithm. For a ...
1999-09-01
Energy Technology Data Exchange (ETDEWEB)
Blade fatigue life is an important element in determining the economic viability of the Vertical-Axis Wind Turbine (VAWT). A principal source of blade fatigue is thought to be the stochastic (i.e., random) aerodynamic loads created by atmospheric turbulence. This report describes the theoretical background of the VAWT Stochastic Aerodynamic Loads (VAWT-SAL) computer code, whose purpose is to numerically simulate these random loads, given the rotor geometry, operating conditions, and assumed turbulence properties. A Double-Multiple-Stream Tube (DMST) analysis is employed to model the rotor's aerodynamic response. The analysis includes the effects of Reynolds number variations, different airfoil sections and chord lengths along the blade span, and an empirical model for dynamic stall effects. The mean ambient wind is assumed to have a shear profile which is described by either a power law or a logarithmic variation with height above ground. Superimposed on this is a full 3-D ...
1991-09-01
Numerical methods for multiphysics, multiphase, and multicomponent models for fuel cells
In this dissertation, we design and analyze efficient numerical methods for obtaining accurate solutions to model problems arising in fuel cells. A basic fuel cell model consists of five principles of conservation, namely, mass, momentum, species, charges (electrons and ions), and thermal energy. Overall, transport equations couple with electrochemical processes through source terms to describe reaction kinetics and electro-osmotic drag in the polymer electrolyte. To model multiphase species transport in the porous media and the gas channel of fuel cells, we consider a multiphase mixture model framework. The diffusivity of the two-phase mixture water conservation equation in this model is nonlinear, discontinuous, and degenerate. To handle this difficulty, we developed efficient and fast nonlinear iterative solvers based on the Kirchhoff transformation and nonlinear Dirichlet-Neumann domain decomposition methods. To model the coupling between the multiphase flow in the porous media and ...
2008-01-01
Energy Technology Data Exchange (ETDEWEB)
This work was carried out to understand the behavior of the solid and gas phases in a CFB riser. Only the riser is modeled as a straight pipe. A model with linear algebraic approximation to solids viscosity of the form, {musubs} = 5.34{epsisubs}, ({espisubs} is the solids volume fraction) with an appropriate boundary condition at the wall obtained by approximate momentum balance solution at the wall to acount for the solids recirculation is tested against experimental results. The work done was to predict the flow patterns in the CFB risers from available experimental data, including data from a 7.5-cm-ID CFB riser at the Illinois Institute of Technology and data from a 20.0-cm-ID CFB riser at the Particulate Solid Research, Inc., facility. This research aims at modeling the removal of hydrogen sulfide from hot coal gas using zinc oxide as the sorbent in a circulating fluidized bed and in the process indentifying the parameters that affect the performance of the sulfidation reactor. ...
2005-07-01
Nuclear heparan sulfate and doubling time in hepatocytes
Energy Technology Data Exchange (ETDEWEB)
A rat hepatocyte cell line was shown previously to contain a nuclear pool of free heparan SO/sub 4/ (HS) chains which turns over rapidly. These cells were labeled with /sup 35/SO/sub 4//sup 2 -/ and the steady state levels of (/sup 35/SO/sub 4/)HS in the nucleus were measured under culture conditions chosen to give different cell doubling times (DT's). In each log phase culture growing at a constant rate, the level of nuclear HS did not change as the cell density increased. Rapidly dividing cells had levels of nuclear HS within the range of 30-42 pmol /sup 35/SO/sub 4/ in the nuclear HS/10/sup 6/ cells. However, in cultures with decreased DT's, there was a corresponding decrease in the level of nuclear HS below 30 pmol/10/sup 6/ cells that was proportional to the decrease in the DT. In contrast, when the cell DT increased in cultures approaching confluence, there was a corresponding increase in the level of nuclear HS above 42 ...
1987-05-01
Natural convection cooling of a vertical channel
International Nuclear Information System (INIS)
An experimental program has been conducted to determine the feasibility of natural convection cooling of a reactor following a beyond-design-based accident. The particular application under consideration was the heavy-water new production reactor. The questions to be resolved include the verification that a natural convection cooling pattern would be established and the determination of the power limit for which convective cooling will occur for a significant period of time. In the experiment, the reactor configuration was simulated using small-diameter vertical heated tubes in parallel with a large-diameter bypass line. Following a loss-of-flow event, the flow in the bypass line will reverse direction and pass through the heated channel by means of natural convection. If, however, the channel power is too high, void formation will block the channel and prevent the reverse flow pattern from occurring. The test procedure involved the establishment of a set of ...
1993-11-14
Multiscale modeling of transdermal drug delivery
This study addresses the modeling of transdermal diffusion of drugs, to better understand the permeation of molecules through the skin, and especially the stratum corneum, which forms the main permeation barrier of the skin. In transdermal delivery of systemic drugs, the drugs diffuse from a patch placed on the skin through the epidermis to the underlying blood vessels. The epidermis is the outermost layer of the skin and can be further divided into the stratum corneum (SC) and the viable epidermis layers. The SC consists of keratinous cells (corneocytes) embedded in the lipid multi-bilayers of the intercellular space. It is widely accepted that the barrier properties of the skin mostly arises from the ordered structure of the lipid bilayers. The diffusion path, at least for lipophilic molecules, seems to be mainly through the lipid bilayers. Despite the advantages of transdermal drug delivery compared to other drug delivery routes such as oral dosing and injections, the low ...
2006-01-01
Multiphase treatment of ODTX in HMX spheres
Energy Technology Data Exchange (ETDEWEB)
What will be discussed in this report represents a framework upon which multiphase and other real physical effects can be built. Chemical models of increasing complexity are envisioned and this methodology can provide a tool for evaluating new ideas against known experimental data. The recent work to be reported here addresses the multiphase issue of temperature deviation between phases undergoing chemical and heat transport processes. Modeling of the LLNL ODTX experiment will be performed with FLUENT, a commercially available computational fluid dynamics (CFD) code. FLUENT solves flows in 2D or 3D in Cartesian, cylindrical, or general curvilinear coordinates, with steady-state of fully time-dependent analysis. Multiphase flows in which two or more continuous phases are present can be solved with arbitrary volumetric sources of heat, mass, momentum, and chemical species applied through user-defined FORTRAN subroutines. FLUENT models these of phenomena by solving ...
1997-12-22
Energy Technology Data Exchange (ETDEWEB)
Pipeline leak detection technologies can be classified according to their specificity, such as their application to offshore or onshore installations or to multi-phase or single-phase flow regimes. They can also be classified according to the technology on which they are based. Available technologies can be categorized into the following 4 groups: (1) compensated mass balance, solving steady state equations which model a specific pipeline, known as real time mode (RTM), (2) the same as group 1, but solving transient equations, known as real time transient model (RTTM), (3) pressure wave behavior, and (4) statistical modeling. Hybrids schemes can also be found. Effective leak detection systems are needed to address the increasing transformation of very large crude cargo (VLCC) ships into floating production, storage and offloading (FPSO) systems. These operations make use of short and large diameters exporting lines, and often involve the use of ...
2004-07-01
Molecular events involved in ionizing radiation induced skin carcinogenesis
International Nuclear Information System (INIS)
The process of mouse skin tumor formation is subdivided into three operational stages. These stages include initiation, promotion and progression. Ionizing radiation has been found to be a weak initiating agent in the production of malignant squamous cell carcinomas, a complete carcinogen and an agent effective in causing tumor progression. Four skin tumor histologies have been seen with ionizing radiation: benign papillomas, squamous (SCC) and basal (BCC) cell carcinomas and fibrosarcomas. Distinct non-ras transforming genes have been detected in radiation initiated SCCs. A benign papilloma cell line (308) was used as a model system to study ionizing radiation induced progression. A variant 308 cell line (308 10 Gy 5) derived by irradiation of the parental 308 cell has been characterized. The 308 10 Gy 5 cells unlike the parental 308 cells from malignant tumors in athymic nude mice upon subcutaneous injection. The variant 308 10 Gy 5 cells unlike the parental cells also show by ...
International Nuclear Information System (INIS)
The commercial Modular High Temperature Gas-Cooled Reactor (MHTGR) achieves improved reactor safety performance and reliability by utilizing an integrated sequence of completely passive thermal storage and heat transfer mechanisms to reject decay heat in the event that all its active cooling systems fail to operate. During such events, the initial heatup transient in the core is followed by a quasi-steady state cooldown process which, if uninterrupted, can continue for several days. A buoyancy-driven natural convection cooling system called the RCCS facilitates the continuous heat removal by circulating ambient air through the reactor cavity, where it is heated and then exhausted to the outside environment. The peak thermal load on the RCCS occurs approximately at the time that the vessel reaches its highest temperature. To confirm the adequacy of the RCCS design, detailed analytical models were developed to simulate the decay heat removal ...
1994-08-01
MONTE CARLO SIMULATIONS OF GLOBULAR CLUSTER EVOLUTION. V. BINARY STELLAR EVOLUTION
International Nuclear Information System (INIS)
We study the dynamical evolution of globular clusters containing primordial binaries, including full single and binary stellar evolution using our Monte Carlo cluster evolution code updated with an adaptation of the single and binary stellar evolution codes SSE and BSE from Hurley et al. We describe the modifications that we have made to the code. We present several test calculations and comparisons with existing studies to illustrate the validity of the code. We show that our code finds very good agreement with direct N-body simulations including primordial binaries and stellar evolution. We find significant differences in the evolution of the global properties of the simulated clusters using stellar evolution compared with simulations without any stellar evolution. In particular, we find that the mass loss from the stellar evolution acts as a significant energy production channel simply by reducing the total gravitational binding energy and can significantly prolong the initial core ...
2010-08-10
Kinetic and mechanistic studies of the reactions of CF{sub 3}O radicals with NO and NO{sub 2}
Energy Technology Data Exchange (ETDEWEB)
The reactions of CF{sub 3}O radicals with (1) NO and (2) NO{sub 2} were studied using two different experimental techniques. A laser photolysis/LIF detection method was applied for measuring the rate constants as a function of temperature (T=222-302 K) and total pressure (p{sub tot}=7-107 mbar). Whereas the reaction with (1) NO was found to be independent of temperature and pressure with k{sub 1}=(4.5{+-}1.2) x 10{sup -11} cm{sup 3}s{sup -1}, the reaction with (2) NO{sub 2} was found to be dependent on both of these variables. The temperature dependence of k{sub 2} in the high pressure limit can be given by the expression k{sub 2{infinity}}{sup -}(T)=(8{+-}5) x 10{sup -13} exp ((863{+-}194) K/T) cm{sup 3}s{sup -1}. The product distributions of the two reactions were determined in separate experiments using steady-state photolysis combined with FTIR spectroscopy. For reaction (1) only CF{sub 2}O was found as a reaction product with a yield of 0.93{+-}0.10, ...
1997-10-01
Energy Technology Data Exchange (ETDEWEB)
This study evaluated potential hydrogeologic mechanisms that may account for increasing moisture content conditions within the sediments of hydroelectric earth dams. Many such dams in Canada are reaching their life spans of approximately 40 years, therefore this study is considered to be an important and timely undertaking. The objective was to develop a method to numerically assess transient groundwater flow processes within old earth structures. The focus of this study was central Manitoba's Grand Rapids Generating Station where progressive movement within the till overburden has been observed since 1977. The possible source of water which is causing higher moisture content and weakness in the overburden material may be the slow wetting-up of the core and progressive increase in seepage to the downstream side. The evolution of flow through the core was evaluated with a modelling program called FRAC3D-VS which accounts for transient groundwater flow under fully-coupled ...
2002-07-01
Horizontal Steam Generator Thermal-Hydraulics at Various Steady-State Power Levels
Three-dimensional computer simulation and analyses of the horizontal steam generator thermal-hydraulics of the WWER 1000 nuclear power plant have been performed for 50% and 75% partial loads, 100% nominal load and 110% over-load. Presented results show water and steam mass flow rate vectors, steam void fraction spatial distribution, recirculation zones, swell level position, water mass inventory on the shell side, and other important thermal-hydraulic parameters. The simulations have been performed with the computer code 3D ANA, based on the 'two-fluid' model approach. Steam-water interface transport processes, as well as tube bundle flow resistance, energy transfer, and steam generation within tube bundles are modelled with {sup c}losure laws{sup .} Applied approach implies non-equilibrium thermal and flow conditions. The model is solved by the control volume procedure, which has been extended in order to take into account the 3D flow of liquid and gas phase. The ...
2002-07-01
Horizontal Steam Generator Thermal-Hydraulics at Various Steady-State Power Levels
International Nuclear Information System (INIS)
Three-dimensional computer simulation and analyses of the horizontal steam generator thermal-hydraulics of the WWER 1000 nuclear power plant have been performed for 50% and 75% partial loads, 100% nominal load and 110% over-load. Presented results show water and steam mass flow rate vectors, steam void fraction spatial distribution, recirculation zones, swell level position, water mass inventory on the shell side, and other important thermal-hydraulic parameters. The simulations have been performed with the computer code 3D ANA, based on the 'two-fluid' model approach. Steam-water interface transport processes, as well as tube bundle flow resistance, energy transfer, and steam generation within tube bundles are modelled with "closure laws". Applied approach implies non-equilibrium thermal and flow conditions. The model is solved by the control volume procedure, which has been extended in order to take into account the 3D flow of liquid and gas phase. The methodology is validated by ...
2002-04-14
GOCE, Satellite Gravimetry and Antarctic Mass Transports
In 2009 the European Space Agency satellite mission GOCE (Gravity Field and Steady-State Ocean Circulation Explorer) was launched. Its objectives are the precise and detailed determination of the Earth's gravity field and geoid. Its core instrument, a three axis gravitational gradiometer, measures the gravity gradient components V xx , V yy , V zz and V xz (second-order derivatives of the gravity potential V) with high precision and V xy , V yz with low precision, all in the instrument reference frame. The long wavelength gravity field is recovered from the orbit, measured by GPS (Global Positioning System). Characteristic elements of the mission are precise star tracking, a Sun-synchronous and very low (260 km) orbit, angular control by magnetic torquing and an extremely stiff and thermally stable instrument environment. GOCE is complementary to GRACE (Gravity Recovery and Climate Experiment), another satellite gravity mission, launched in 2002. While ...
2011-03-01
Fluxes of H+ and K+ in corn roots
International Nuclear Information System (INIS)
We report here on an experimental system that utilizes ion-selective microelectrodes to measure the electrochemical potential gradients for H"+ and K"+ ions within the unstirred layer near the root surface of both tact 4-day-old corn seedlings and corn root segments. Analysis of the steady state H"+ and K"+ electrochemical potential gradients provided a simultaneous measure of the fluxes crossing a localized region of the root surface. Net K"+ influx values obtained by this method were compared with unidirectional K"+ ("8"6Rb"+) influx kinetic data; at any particular K"+ concentration, similar values were obtained by either technique. The ion-specific microelectrode system was then used to investigate the association between net H"+ efflux and net K"+ influx. Although the computed H"+K"+ stoichiometry is dependent upon the choice of diffusion coefficients, the values obtained were extremely variable, and net K"+ influx rarely appeared to be ...
1987-01-01
Final report on process modeling of cupola furnaces
This report describes the first phase of the AFS/DOE program on mathematical modeling of cupola behavior, covering the period May 19, 1989 to July 19, 1990. The objective of the program is to develop a comprehensive mathematical model of the cupola furnace for on-line and off-line process control and optimization. The work is being carried out by five organizations: Massachusetts Institute of Technology with responsibility for heat transfer and fluid flow modeling, and incorporation of the chemical models being developed by the University of Michigan team. Modern Equipment Company has the responsibility of compiling information on needed sensors for monitoring operation and providing materials data to be used for cupola input. General Motors, Central Foundry Division, is investigating the potential to augment the mathematical models with artificial intelligence programs. Lastly, General Motors Research laboratories are charged with providing accurate cupola operational data to test the ...
1990-07-01
Fabrication and dielectric property of ferroelectric PLZT films grown on metal foils.
Energy Technology Data Exchange (ETDEWEB)
We have grown ferroelectric Pb{sub 0.92}La{sub 0.08}Zr{sub 0.52}Ti{sub 0.48}O{sub 3} (PLZT) films on platinized silicon and LaNiO{sub 3}-buffered nickel substrates by chemical solution deposition using a sol-gel process based on acetic acid chemistry. The following measurements were obtained under zero-bias field: relative permittivity of {approx}960 and dielectric loss of {approx}0.04 on the PLZT film grown on Pt/Si substrates, and relative permittivity of {approx}820 and dielectric loss of {approx}0.06 on the PLZT film grown on LNO-buffered Ni substrates. In addition, a relative permittivity of 125 and dielectric loss of 0.02 were measured at room temperature under a high bias field of 1 x 10{sup 6} V/cm on PLZT deposited on LNO-buffered nickel substrate. Furthermore, a steady-state leakage current density of {approx}8.1 x 10{sup -9} A/cm{sup 2} and mean breakdown field strength of 1.7 x 10{sup 6} V/cm were measured at room temperature. Finally, remanent ...
2011-07-01
Energy Technology Data Exchange (ETDEWEB)
The use of aqueous methyldiethanolamine (MDEA) for selective removal of hydrogen sulfide from acid gas streams has been studied in a 2 inch column packed with 1/4 inch ceramic Intalox saddles. The column was operated in a counter-current, steady state fashion. The feed gas composition varied between 1 and 5 mole % hydrogen sulfide and between 0 and 50 mole % carbon dioxide. In order to assist the development of packed column absorption models, the rate at which pure carbon dioxide absorbs into 2 M MDEA was measured as a function of pressure, liquid flow rate and packed bed length. The importance of end effects was carefully evaluated. In addition, draining and tracer methods were used to estimate the amount of static holdup present in the column. Using classical draining methods, as much as 50 % of the total holdup was found to be static. However, according to the step decrease in tracer method, less than 5 % of the total holdup was static. ...
1988-01-01
Experimental and theoretical studies on humidification-dehumidification-desalination
Energy Technology Data Exchange (ETDEWEB)
The shortage of fresh water is increasing at alarming levels, even in temperate zones. Desalination of brackish and seawater is being considered as a solution to growing water demands. Seawater desalination can be accomplished through reverse osmosis, vapor compression, vapor absorption and thermally driven systems. The most suitable process for large-scale desalination plants is successive brine evaporation-condensation with intermediate heat recovery. However, higher process efficiency could be achieved. The use of low temperature heat sources in seawater desalination requires an efficient method of evaporation and condensation at relatively low vapor pressures. This could be achieved in a humidification-dehumidification process using circulated air to enhance evaporation of water. Simulation models, however, neglect either the heat of evaporation or the changes in air and water properties within humidification and condensation towers. Therefore, the purpose of this study was to ...
2006-07-01
International Nuclear Information System (INIS)
The proposed method to analyze the composition of the cost of electricity is based on the energy conversion processes and the destruction of the exergy through the several thermodynamic processes that comprise a combined cycle power plant. The method uses thermoeconomics to evaluate and allocate the cost of exergy throughout the processes, considering costs related to inputs and investment in equipment. Although the concept may be applied to any combined cycle or cogeneration plant, this work develops only the mathematical modeling for three-pressure heat recovery steam generator (HRSG) configurations and total condensation of the produced steam. It is possible to study any nx1 plant configuration (n sets of gas turbine and HRSGs associated to one steam turbine generator and condenser) with the developed model, assuming that every train operates identically and in steady state. The presented model was conceived from a complex configuration of a ...
2008-02-01
Energy Technology Data Exchange (ETDEWEB)
This thesis surveys the concepts of exergy and extends the exergy method of analysis from the standpoint of its applications to the power plant systems. After a brief historical review of exergy concepts, the general exergy equation is derived from the combined equation of First and Second Law, and it is shown that any special case of exergy equation is a simplified form of the general exergy equation. The mathematical method for the exergy analysis of a steady-state, steady-flow system, analogous to that of the First Law, is given. The exergy losses in a power plant are discussed. Then in order to examine these losses, the Second Law performance of major processes of combustion, compression, heat transfer, mixing and throttling have been analyzed analytically, and the exergy efficiencies are defined that accurately assess the thermodynamic performance of the corresponding processes. The methods for computation of exergy loss and exergy efficiency are given and ...
1981-01-01
Effect of boric acid on steam generator corrosion
International Nuclear Information System (INIS)
Project RPS116, ''Implementation of Boric Acid in the Field,'' was designed to demonstrate that a selected steam generator boric acid treatment is effective in arresting the progressing of denting in an operating steam generator. The PWR nuclear steam generators chosen for the testing were those at the Indian Point Unit 3 nuclear site. Hydrogen monitoring measurements and eddy current examinations had indicated that the Indian Point Unit 3, Series 44 steam generators had already reached an advanced stage of denting and tube support plate ligament discontinuities were observed. The objective of the boric acid treatment was to reduce the rate of denting by attempting to reproduce in the field the positive results achieved with boric acid in laboratory-simulated denting tests. Laboratory testing has indicated that implementation of a four day low power (25% power) boric acid soak with 50 ppm boron as boric acid followed by maintenance of a 5-10 ppm boron level during full power operation ...
1985-03-01
Direct liquefaction Proof-of-Concept facility. Final technical progress report
Energy Technology Data Exchange (ETDEWEB)
This report presents the results of work which included extensive modifications to HRI`s existing 3 ton per day Process Development Unit (PDU) and completion of the first PDU run. The 58-day Run 1 demonstrated scale-up of the Catalytic Two-Stage Liquefaction (CTSL Process) on Illinois No. 6 coal to produce distillate liquid products at a rate of up to 5 barrels per to of moisture-ash-free coal. The Kerr McGee Rose-SR unit from Wilsonville was redesigned and installed next to the US Filter installation to allow a comparison of the two solids removal systems. Also included was a new enclosed reactor tower, upgraded computer controls and a data acquisition system, an alternate power supply, a newly refurbished reactor, an in-line hydrotreater, interstage sampling system, coal handling unit, a new ebullating pump, load cells and improved controls and remodeled preheaters. Distillate liquid yields of 5 barrels/ton of moisture ash free coal were achieved. Coal slurry recycle rates were ...
1995-08-01
Development on the technologies for tritium removal processes
Energy Technology Data Exchange (ETDEWEB)
While tritium exposure to the site-workers in Wolsung NPP is upto about 40 % of the total personnel exposure, Korea Institute of Nuclear Safety has asked tritium removal facility, as one of the requirements for post reactor construction, after operation of four CANDU reactors in Wolsung site. For the purpose of essential removal of tritium from the heavy water system of the heavy water reactors, an experiment of Ar-N{sub 2} cryogenic distillation tower was carried out as a preliminary study for development of liquid-phase catalytic exchange - cryogenic hydrogen distillation process. The steady-state reached after 50 minutes under 90 K in the Ar-N{sub 2} distillation column (inner diameter 20 mm, height 500 mm) packed with Dixon ring ({phi} 3 mm x H 3 mm), and the ratios of Ar-concentration at the top and at the bottom measured by gas chromatography within {+-}1 % relative error was approximately 93 : 3. This value was distillation performances quite higher than ...
1994-12-01
Central engine of quasars and AGNs: a relativistic proton radiative shock
International Nuclear Information System (INIS)
Active galactic nuclei (AGNs) and quasars (QSOs) appear to emit roughly equal energy per decade from radio to gamma-ray energies (e.g. Ramaty and Ligenfelter 1982). This argues strongly for a nonthermal radiation mechanism (see Rees 1984). In addition, statistical studies have indicated that the spectra of these objects in the IR-UV and 2 to 50 keV x-ray band, can be fitted very well with power laws of specific indices. These spectral indices do not seem to depend on the luminosity or morphology of the objects (Rothschild et al. 1983; Malkan 1984), and any theory should account for them in a basic and model independent way. If shocks accelerate relativistic protons via the first-order Fermi mechanism (e.g. Axfor 1981), the radiating electrons can be produced as secondaries throughout the source by proton-proton (p-p) collisions and pion decay, thus eliminating Compton losses (Protheroe and Kazanas 1983). As shown by Kazanas (1984), if relativistic electrons are injected at high ...
1985-08-01
Energy Technology Data Exchange (ETDEWEB)
Numerous studies have investigated degradation of individual endocrine disrupting compounds (EDCs) in lab or natural waters. However, natural variations in water matrices and mixtures of EDCs in the environment may confound analysis of the treatment efficiency. Because chemical based analytical methods cannot represent the combined or synergistic activities between water quality parameters and/or the EDC mixtures at environmentally relevant concentrations ({mu}g L{sup -1}-ng L{sup -1}), bioanalytical assessments of residual estrogenic activity in treated water were used to evaluate the performance of the UV based advanced oxidation process for estrogenic contaminants in water. Four EDCs including estradiol (E{sub 2}), ethinyl estradiol (EE{sub 2}), bisphenol-A (BPA) and nonylphenol (NP) were spiked individually or as a mixture at {mu}g L{sup -1}-ng L{sup -1} in laboratory or natural river water. The removal rates of estrogenic activity were quantitatively evaluated by in vitro yeast ...
2007-04-15
Energy Technology Data Exchange (ETDEWEB)
This paper presented a technique to compensate for distorted secondary currents. Since current distortion can cause operating time delays in protective relays, attempts are made to minimize current transformer (CT) saturation by choosing a CT with a voltage rating that is at least twice that required for the maximum steady-state symmetrical fault current. However, the possibility of saturation still exists because of the DC component of an asymmetrical fault current and the remanent flux in a CT core. An advanced algorithm for the compensation of the distorted signal due to CT saturation was proposed. The secondary current can be expressed as the linear combination of sinusoidal and exponential signals, if no saturation occurs. In this study, the algorithm first utilized the third difference function for detecting the start and end of saturation in real-time. The AR model-based FIR filter and the least mean square curve fitting method were then used to estimate the ...
2006-07-01
DEFF Research Database (Denmark)
Antisense- or RNAi-mediated suppression of the biosynthesis of nutritionally inferior storage proteins is a promising strategy for improving the amino acid profile of seeds. However, the potential pleiotropic effects of this on interconnected pathways and the agronomic quality traits need to be addressed. In the current study, a transcriptomic analysis of an antisense C-hordein line of barley was performed, using a grain-specific cDNA array. The C-hordein antisense line is characterized by marked changes in storage protein and amino acid profiles, while the seed weight is within the normal range and no external morphological irregularities were observed. The results of the transcriptome analysis showed excellent correlation with data on changes in the relative proportions of storage proteins and amino acid composition. The antisense line had a lower C-hordein level and down-regulated transcript encoding C-hordein. The production of the S-rich B/gamma- and D-hordeins was increased and ...
2007-01-01
DEFF Research Database (Denmark)
Antisense- or RNAi-mediated suppression of the biosynthesis of nutritionally inferior storage proteins is a promising strategy for improving the amino acid profile of seeds. However, the potential pleiotropic effects of this on interconnected pathways and the agronomic quality traits need to be addressed. In the current study, a transcriptomic analysis of an antisense C-hordein line of barley was performed, using a grain-specific cDNA array. The C-hordein antisense line is characterized by marked changes in storage protein and amino acid profiles, while the seed weight is within the normal range and no external morphological irregularities were observed. The results of the transcriptome analysis showed excellent correlation with data on changes in the relative proportions of storage proteins and amino acid composition. The antisense line had a lower C-hordein level and down-regulated transcript encoding C-hordein. The production of the S-rich B/ - and D-hordeins was increased and ...
2007-01-01
An overview of AECL's participation in the Korean Wolsung Tritium Removal Facility Project (WTRF)
International Nuclear Information System (INIS)
Full text: In heavy-water-moderated power reactors, tritium is primarily produced by neutron capture in deuterium nuclei in the moderator and coolant. For CANDU 6 reactors, the estimated steady-state values are #approx# 3 TBq#centre dot#kg"-"1 D_2O in the moderator and #approx# 74 GBq#centre dot#kg"-"1 D_2O in the coolant. Tritium removal is one option available to reactor operators for use in their heavy water and tritium management strategies. The WTRF is designed to remove tritium from tritiated heavy water in each of the four CANDU units at the Wolsung Site, to immobilize the tritium and to store it on site. The detritiation process is based on three steps: the first one (front-end) involves the transfer of tritium from heavy water to deuterium gas; the second one (enrichment) concentrates the tritium in a cryogenic distillation system to produce essentially pure D_2 and T_2 streams; and in the third step the tritium is packaged for long-term storage. The WTRF ...
2007-11-07
An Arabidopsis thaliana methyltransferase Capable of Methylating Farnesoic Acid
Energy Technology Data Exchange (ETDEWEB)
We previously reported the identification of a new family of plant methyltransferases (MTs), named the SABATH family, that use S-adenosyl-l-methionine (SAM) to methylate a carboxyl moiety or a nitrogen-containing functional group on a diverse array of plant compounds. The Arabidopsis genome alone contains 24 distinct SABATH genes. To identify the catalytic specificities of members of this protein family in Arabidopsis, we screened recombinantly expressed and purified enzymes with a large number of potential substrates. Here, we report that the Arabidopsis thaliana gene At3g44860 encodes a protein with high catalytic specificity towards farnesoic acid (FA). Under steady-state conditions, this farnesoic acid carboxyl methyltransferase (FAMT) exhibits K{sub M} values of 41 and 71 {mu}M for FA and SAM, respectively. A three-dimensional model of FAMT constructed based upon similarity to the experimentally determined structure of Clarkia breweri salicylic acid ...
2006-01-01
A wirelessly powered and controlled device for optical neural control of freely-behaving animals.
Optogenetics, the ability to use light to activate and silence specific neuron types within neural networks in vivo and in vitro, is revolutionizing neuroscientists' capacity to understand how defined neural circuit elements contribute to normal and pathological brain functions. Typically, awake behaving experiments are conducted by inserting an optical fiber into the brain, tethered to a remote laser, or by utilizing an implanted light-emitting diode (LED), tethered to a remote power source. A fully wireless system would enable chronic or longitudinal experiments where long duration tethering is impractical, and would also support high-throughput experimentation. However, the high power requirements of light sources (LEDs, lasers), especially in the context of the extended illumination periods often desired in experiments, precludes battery-powered approaches from being widely applicable. We have developed a headborne device weighing 2 g capable of wirelessly receiving power using a ...
2011-06-23
According to the LeChatelier-Braun principle, when a closed quiescent system initially in an equilibrium or unstressed steady state is subjected to an externally imposed ``stress'' it responds in a manner tending to alleviate that stress. Use of this entropically based qualitative rule, in combination with the notion of Maxwell thermal stresses existing in nonisothermal gases and liquids, enables one to (i) derive Maxwell's thermal-creep boundary condition prevailing at the boundary between a solid and a fluid (either gas or liquid) and (ii) rationalize the phenomenon of thermophoresis in liquids, for which, in contrast with the case of gases, an elementary explanation is currently lacking. These two objectives are achieved by quantitatively interpreting the heretofore qualitative LeChatelier-Braun notion of stress in the present context as being the fluid's stress tensor, the latter including Maxwell's thermal stress. In effect, thermophoretic ...
2009-05-01
A desiccant dehumidifier for electric vehicle heating
Energy Technology Data Exchange (ETDEWEB)
Vehicle heating requires a substantial amount of energy. Engines in conventional cars produce enough waste heat to provide comfort heating and defogging/defrosting, even under very extreme conditions. Electric vehicles (EVs), however, generate little waste heat. Using battery energy for heating may consume a substantial fraction of the energy storage capacity, reducing the vehicle range, which is one of the most important parameters in determining EV acceptability. Water vapor generated by the vehicle passengers is in large part responsible for the high heating loads existing in vehicles. In cold climates, the generation of water vapor inside the car may result in water condensation on the windows, diminishing visibility. Two strategies are commonly used to avoid condensation on windows: windows are kept warm, and a large amount of ambient air is introduced in the vehicle. Either strategy results in a substantial heating load. These strategies are often used in combination, and a ...
1996-09-01
The chemistry of technetium(V) complexes containing tetradentate amine oxime ligands
International Nuclear Information System (INIS)
Technetium-99m was previously shown to form a stable, neutral and lipopholic complex with propylene amine oxime, PnAO. This Tc-99m-PnAO complex was shown to efficiently extracted by normal brain. However, it is not sufficiently retained in the brain to image its cerebral distribution using convertional SPECT (single-photon emission computerized tomography) instrumentation. A number of derivatives of PnAO have been synthesized and their technetium-99m complexes have been biologically evaluated. A number of these have been shown to have high brain uptake without exhibiting the rapid cerebral clearance that was observed with Tc-99m-PnAO. To better understand the chemistry of these potential brain imaging agents, a number of technetium-99 complexes of derivatives of PnAO have been synthesized and characterized. Substituents on the tetradentate amine oxime backbone were varied to probe the effect(s) of these structural changes on the properties of ...
Technetium-99m dithiocarbamates as potential agents for brain imaging
International Nuclear Information System (INIS)
Thallium-201 diethyldithiocarbamate (DDC) behaves like a chemical microsphere and is trapped by spontaneous decomposition in the brain in proportion to regional perfusion. They have shown that the technetium-99m analog, Tc-99m DDC (1), is unsuitable for cerebral perfusion imaging because it does not decompose rapidly enough to be trapped in the brain. With the goal of turning this greater stability of 1 into an advantage, a series of dithiocarbamates with lipophilic or amine groups designed to enhance cerebral uptake and retention was prepared from the following amines by reaction with carbon disulfide and sodium hydroxide: pyrrolidine (2), piperazine (3), 4-benzylpiperazine (4), and 4-(1-piperidino)piperidine (5). These ligands (5 mg) were labelled with Tc-99m in > 95% efficiency (ITLC-SG, saline) by reduction of pertechnetate at room temperature with formamidine sulfinic acid at alkaline pH. In preliminary studies, 4 and 5 show a trend of ...
Study of spatial resolution in three-dimensional rotational angiography
International Nuclear Information System (INIS)
In interventional radiology (IVR) of cerebral aneurysms, it is important to understand the form and physical relationships between the cerebral aneurysm and the surrounding vessels. However, because the vessels in the head area are highly complex, it can be difficult to comprehend the structure using conventional angiography. Therefore, three-dimensional rotational angiography (3D-RA) has been used in recent years. This article discusses studies of the spatial resolution of 3D-RA. We reconstructed 3D-RA of an acrylic slit phantom (slit widths: 0.5, 0.75, 1.0, 1.5 mm) and examined spatial resolution by visual evaluation and profile curves. When the slit phantom was arranged to avoid the effect of beam hardening, the spatial resolution of 3D-RA was found to be as high as 0.75 mm. When the slit phantom was placed orthogonal to the rotational axis of the C-arm, the spatial resolution of 3D-RA was decreased because of the cone angle effect of ...
2006-03-01
Energy Technology Data Exchange (ETDEWEB)
Non-invasive methods are described for estimating local cerebal blood flows (LCBF) and local partition coefficients (Llambda) during inhalation of 30 % stable xenon gas (Xe) in oxygen during CT scanning. After the denitrogenation with pure oxygen breathing, 30 % Xe is inhaled for four minutes to minimize subanesthetic effects with a rubber facemask and the delivery system of Xe. Local time-..delta.. Hounsfield units curve during the Xe wash-in and wash-out phase is utilized in order to calculate Llambda and LCBF using a least squares curve fitting analysis. Calculated Llambda and LCBF with the new method manifested reasonable distribution between the grey and white matters, and reproducibility was excellent in our study. Several case studies of patients with cerebral infarction are presented to demonstrate the characterization of Llambda and LCBF patterns in various tissues and theoretical grounds underlying the new method of curve fitting analysis are discussed.
1988-07-01
International Nuclear Information System (INIS)
Non-invasive methods are described for estimating local cerebal blood flows (LCBF) and local partition coefficients (L#lambda#) during inhalation of 30 % stable xenon gas (Xe) in oxygen during CT scanning. After the denitrogenation with pure oxygen breathing, 30 % Xe is inhaled for four minutes to minimize subanesthetic effects with a rubber facemask and the delivery system of Xe. Local time-#DELTA# Hounsfield units curve during the Xe wash-in and wash-out phase is utilized in order to calculate L#lambda# and LCBF using a least squares curve fitting analysis. Calculated L#lambda# and LCBF with the new method manifested reasonable distribution between the grey and white matters, and reproducibility was excellent in our study. Several case studies of patients with cerebral infarction are presented to demonstrate the characterization of L#lambda# and LCBF patterns in various tissues and theoretical grounds underlying the new method of curve fitting analysis are ...
MRS of normal and impaired fetal brain development
International Nuclear Information System (INIS)
Cerebral maturation in the human fetal brain was investigated by in utero localized proton magnetic resonance spectroscopy (MRS). Spectra were acquired on a clinical MR system operating at 1.5 T. Body phased array coils (four coils) were used in combination with spinal coils (two coils). The size of the nominal volume of interest (VOI) was 4.5 cm"3 (20 mm x 15 mm x 15 mm). The MRS acquisitions were performed using a spin echo sequence at short and long echo times (TE = 30 ms and 135 ms) with a VOI located within the cerebral hemisphere at the level of the centrum semiovale. A significant reduction in myo-inositol and choline and an increase in N-acetylaspartate were observed with progressive age. The normal MR spectroscopy data reported here will help to determine whether brain metabolism is altered, especially when subtle anatomic changes are observed on conventional images. Some examples of impaired fetal brain development studied by MRS are ...
2006-02-01
Incidental brain lesions on MRI in the depressive elderly
Energy Technology Data Exchange (ETDEWEB)
The study was designed to determine the correlation between parenchymal lesions on MRI and depression. Thirty patients with depression satisfying the following criteria were selected: (1) 60 years or over at the time of MRI scanning, (2) no evidence of cerebrovascular disorder or dementia, and (3) no evidence of neurological findings such as extremity palsy. Seventy six patients with no history of psychiatric visits to a clinic served as controls. There was no significant difference in risk factors for cerebrovascular disorders, such as hypertension, diabetes mellitus, and ischemic heart disease, between the depressive group and the control group. MRI manifestations were semiquantitatively scored according to the periventricular hyperintensity (PVH), white matter hyperintensity (WMH), and pons hyperintensity (PH). All of the PVH score, WMH score, and cerebral enlargement index correlated with age. Although there was no significant difference in the incidence of ...
1994-07-01
Energy Technology Data Exchange (ETDEWEB)
A beta microprobe was successfully applied to monitor arterial input function for quantification of regional cerebral blood flow (rCBF) in the monkey brain with {sup 15}O-water and positron emission tomography (PET). The sensitivity of the probe was approximately 0.83 to 1.67 cps/kBq/ml depending on the studies. A preliminary study was performed to find a suitable use and to evaluate the performance of the system and data analysis procedure. The results showed that dispersion correction of measured input function was unnecessary if microprobes were connected directly to the arterial catheter. Then multiple CBF measurements were done in three monkeys under anesthesia. Identical regions of interest were placed with the aid of magnetic resonance imaging (MRI) of each monkey and rCBF values were estimated. Estimated rCBFs were reproducible for several measurements. The mean CBF value for a pentobarbital anesthetized monkey was 46.0 ml/min/100 g (PaCO{sub 2}=46.3 mmHg). ...
1998-02-01
A study on brain CT of neurological endemic cretinism
International Nuclear Information System (INIS)
A study on brain CT was made in 20 cases of typical endemic cretinism and 15 cases of normal persons. These patients from severely iodine deficient area were diagnosed as neurological endemic cretinism characterized by severe mental retardation with impairment of hearing, speech, neuromotor, etc. to varying degrees. The brain CT showed that there were many and deep depressions in cerebral cortex, especially in frontal and parietal lobes of some cretins, the lateral ventricle system was dilated, particularly in posterior part of it, and the interhemisphere fissure, lateral fissure and subarachnoid cisterns were also expanded. The CT value of cortex was higher and white matter was lower than that of normal persons. In some severe cases, the two hemispheres of brain were not the same in size. These findings above indicated that these endemic cretins had a severe retardation of brain development including cerebral cortex and white matter. In ...
[Method of determining tissue renin activity using heterologous serum].
The authors described a method for determination of tissue renin activity with heterologous substrate. The preparation of the substrate was performed at several stages: salting with amonium sulfate; dialisis of the precipitate till complete separation of amonium sulfate molecules; distruction of angiotensinases by interchangeble souring and alcalization of the medium; lyophylization of the pure substrate. The obtained renin-substrate was preserved in ampules and its usage had a series of advantages--duration, economic, a possibility for standartization of the determination, etc., which were described in details in the article. The described in details also the quantitative determination of the renin activity in the tissues (renal and cerebral) with the help of the obtained substrate as the moments, modiied by the authors, were indicated. PMID:436712
1979-01-01
Neuroinflammation and brain infections: Historical context and current perspectives
British Library Electronic Table of Contents (United Kingdom)
An overview of current concepts on neuroinflammation and on the dialogue between neurons and non-neuronal cells in three important infections of the central nervous systems (rabies, cerebral malaria, and human African trypanosomiasis or sleeping sickness) is here presented. Large numbers of cases affected by these diseases are currently reported. In the context of an issue dedicated to Camillo Golgi, historical notes on seminal discoveries on these diseases are also presented. Neuroinflammation is currently closely associated with pathogenetic mechanisms of chronic neurodegenerative diseases. Neuroinflammatory signaling in brain infections is instead relatively neglected in the neuroscience community, despite the fact that the above infections provide paradigmatic examples of alterations o...
2011-01-01
Magnetic resonance imaging of the pediatric brain
International Nuclear Information System (INIS)
The atlas presents sequences of MRI sections parallel to the orbito-meatal plane in children from birth through the age of sixteen years. Each child was studied horizontally and sagitally and three-dimensional brain images were reconstructed to facilitate accurate identification of sulci and gyri. The images show crucial aspects of brain development such as the constancy of the brain stem and primitive brain from birth onward; the development of the telencephalon, characterized by deepening of sulci and growth of the cerebral cortex surface; and the different stages of white matter myelinization.
Differential diagnosis by CT units with contrast enhancement
Energy Technology Data Exchange (ETDEWEB)
Variation of CT units, in organs, before and after using contrast enhancing medium was reviewed and personal experience was presented. In the normal brain CT units was little changed by contrast enhancement (CE), whereas remarkable change was observed at lesions. No difference of CT units was observed between the normal liver and hepatomas. The normal kidney had higher CE effect than hypernephromas suggesting an increase of the sensitivity. CE was not found in cysts or necrosis. The changes of CT units in the cases of cerebral diseases are tabled with various contrast medium and scanners.
1981-04-01
Computed tomography in the evaluation of 41 cases of Ewing's sarcoma
International Nuclear Information System (INIS)
Computed tomography (CT) has already proved extremely effective both in cerebral and abdominal pathology. Several recent publications describing first heterogeneous series [1, 2, 7, 11-17], then studies of a single type of lesion [3-6, 8] have illustrated its usefulness in the study of bone lesions. This report deals with 41 cases of Ewing's sarcoma studied by CT at the Institut Gustave Roussy from October 1977 to July 1981, and tries to show both the limitations and indications of this technique for the diagnosis, treatment, and follow-up of Ewing's sarcoma as well as in the diagnosis of any eventual recurrence. (orig.).
Cerebral angiography using Fuji computed radiography (FCR) system
International Nuclear Information System (INIS)
Eighty-seven subtraction images of FCR were compared with subtraction images of conventional angiography. Although FCR images with reduced exposure dose (25 % of regular dose) and with diluted contrast material (150 mgI/ml, 50 % of usual concentration) were slightly inferior to the images of conventional angiography, most clinically important vessels were adequately visualized. As FCR has wider dynamic range and higher contrast resolution than conventional angiography, FCR may take over conventional angiography. (author).
1985-01-01
Energy Technology Data Exchange (ETDEWEB)
We studied 129 AIDS patients with suspected or proved intracranial manifestations of the disease. The purpose of this study was to compare the diagnostic sensitivity of unenhanced and contrast enhanced CT and unenhanced T{sub 2}-weighted MR. Thus, in 20% of our patients MR but not CT was diagnostic. In another 20% MR provided additional diagnostic information. In conclusion, MR is recommended as the imaging modality of choice in AIDS patients with non-conclusive cranial CT. (orig./GDG).
1990-09-01
Energy Technology Data Exchange (ETDEWEB)
We present a case of cerebral aspergillosis in an immunocompetent patient. The MRI signal characteristics were compared with the histologic findings. Irregular low-signal zones were demonstrated between the wall of the abscess and the central necrosis on T2-weighted images; the pathology specimen revealed concentrated iron in these transitional zones but no hemosiderin. Iron is an essential element for the growth of fungal hyphae. The low-signal zones may represent the areas where there was active proliferation of aspergillus, and the unique location of the low signal may be a helpful imaging characteristic for the diagnosis of an aspergillus abscess. (orig.)
2001-07-01
International Nuclear Information System (INIS)
Cerebral blood flow (CBF) and cerebrovascular reserve capacity (CRC) were measured by stable xenon computerized tomography (Xe-CT) and acetazolamide test in 15 patients with cerebrovascular disease before and after extracranial-intracranial (EC-IC) bypass surgery for minor stroke, reversible ischemic neurological deficit or transient ischemic attack. All had angiographically shown occlusive lesions of the major arterial trunk. In the present series, global analysis showed that the bypass did not increase the resting rCBF, but did increase the rCRC. We divided the patients into four groups according to the preoperative resting rCBF and rCRC. All 3 patients with normal resting rCBF and reduced rCRC showed postoperative improvement of rCRC. Of 6 patients with reduced CBF and reduced CRC, three had postoperative increase in resting CBF and four had increased CRC. One of two patients with reduced CBF and normal CRC showed only an increase in CRC. We propose that reduced ...
Magnetic Resonance Perfusion Imaging in Malformations of Cortical Development
International Nuclear Information System (INIS)
Background: Malformations of cortical development vary in neuronal maturity and level of functioning. Purpose: To characterize regional relative cerebral blood volume (rCBV) and difference in first moment transit time (TTfm) in polymicrogyria and cortical tubers using magnetic resonance (MR) perfusion imaging. Material and Methods: MR imaging and dynamic T2*-weighted MR perfusion imaging were performed in 13 patients with tuberous sclerosis complex, 10 with polymicrogyria, and 18 controls with developmental delay but no macroscopic brain abnormality. Regions of interest were placed in cortical tubers or polymicrogyric cortex and in the contralateral normal-appearing side in patients with malformations. In 'control' subjects, regions of interest were placed in the frontal and parietal lobes in both hemispheres. The rCBV and TTfm of the tuber/contralateral side (rCBVRTSC and TTFMTSC) as well as those of the polymicrogyria/contralateral side (rCBVRPMG and TTFMPMG) ...
2007-10-01
International Nuclear Information System (INIS)
Purpose: To assess the relationship between large intracranial vessel occlusive vasculopathy (vasculopathy) and radiation therapy, and to clarify the clinical efficacy of magnetic resonance (MR) imaging in the diagnosis and screening of the vasculopathy. Methods and Materials: We retrospectively evaluated the medical records and serial MR images for 32 pediatric patients, in whom radiation therapy had been given to fields including the circle of Willis and major cerebral arteries. All children had periodically undergone follow-up neurologic assessment and MR imaging examinations at Kanagawa Children's Medical Center for more than one year after radiation therapy (range 1.3-14 years). Patients who had not remained free of tumor progression up to the time of final evaluation were excluded. Results: Vasculopathy developed in 6 of 32 patients 2-13 years after radiation therapy. Three of them presented with transient ischemic attacks (TIA) and the other three showed ...
1997-05-01
Energy Technology Data Exchange (ETDEWEB)
Homologous and heterologous arterial segments were implanted in Fisher rats subcutaneously for the purpose of examining the antibody titer of the recipients' serum after implantation by means of the immune-adherence hemagglutination method. The antibody titer after implantation both of homologous and heterologous grafts decreased to 1/8 by 2.0 million (M) rads irradiation of high voltage cathode rays. The results suggested that high voltage cathode ray irradiation was not enough for heterologous graft to suppress its tissue reaction. Homografts taken from dogs 3 or 6 hours after sacrifice were irradiated with 2.0 M rads and transplanted in canine carotid artery using the technic of end-to-end anastomosis. Angiograms 6 months after operation revealed excellent patency rate in all the grafts of 28 dogs. furthermore, findings of the grafts from 1 week to 5 years after operation on scanning and transmission electron microscopies were evaluated. Clinical application of bypass ...
1982-06-01
International Nuclear Information System (INIS)
Homologous and heterologous arterial segments were implanted in Fisher rats subcutaneously for the purpose of examining the antibody titer of the recipients' serum after implantation by means of the immune-adherence hemagglutination method. The antibody titer after implantation both of homologous and heterologous grafts decreased to 1/8 by 2.0 million (M) rads irradiation of high voltage cathode rays. The results suggested that high voltage cathode ray irradiation was not enough for heterologous graft to suppress its tissue reaction. Homografts taken from dogs 3 or 6 hours after sacrifice were irradiated with 2.0 M rads and transplanted in canine carotid artery using the technic of end-to-end anastomosis. Angiograms 6 months after operation revealed excellent patency rate in all the grafts of 28 dogs. furthermore, findings of the grafts from 1 week to 5 years after operation on scanning and transmission electron microscopies were evaluated. Clinical application of bypass surgery from ...
1982-01-01
Effects of chronic ingestion of tritiated water on prenatal brain development
International Nuclear Information System (INIS)
In view of the anticipated increased use of atomic energy in industry, the possible long-term effects of chronic radiation exposure were studied in five generations of rats. Female rats (F_0) were given tritiated drinking water ("3HOH;3#mu#Ci/ml) from adolescence (60 days) until and throughout pregnancy. A separate study showed that the maximum radioactivity in the urine is reached in 30 days, and in the blood in 42 days. In the newborns, the highest specific activity was in the nucleic acid fraction, but total radioactivity was mainly due to the water (body fluids) compartment. No signs of radiation illness or increase in cataract formation in the mothers were observed. The food and water intake and body weight changes before pregnancy were normal. The course and the outcome of pregnancy were also normal. However, 60% of the newborns (F_1) exhibited hematomas, edemas, and subdural hemorrhages, which disappeared at 30 days of age. Bollod analysis of the F_1 offspring at various ages ...
Diffusion and perfusion MR imaging in stroke; MR-Diffusion und -Perfusion beim Schlaganfall
Energy Technology Data Exchange (ETDEWEB)
Magnetic resonance imaging (MRI) in stroke makes it possible to visualize the initial infarct in cases of acute cerebral ischemia. Perfusion MRI serves to determine which tissues are additionally at risk of infarction due to persistent hypoperfusion. MRI also allows those examiners with limited experience to reliably confirm an infarct. The most important differential diagnosis of cerebral ischemia, intracerebral hemorrhage, can likewise be recognized with certainty using MRI. Although diffusion and perfusion MRI only demonstrate the pathophysiology of cerebral ischemia approximately, the method is suited for identifying those patients who would profit from reperfusion therapy. Whether MRI is also appropriate as an aid to reaching a prognosis on the risk of secondary hemorrhage has not yet been resolved. (orig.) [German] Die Schlaganfall-MRT ermoeglicht es, bei akuter zerebraler Ischaemie den bereits initial entstandenen ...
2005-05-01
Computed tomograms of the newborn
International Nuclear Information System (INIS)
Computed tomograms (CT) from 204 cases of premature and full term infants were studied. 1) In 70 infants of hyaline membrane disease, primary apnea and asymptomatic transient hypoglycemia and hypocalcemia, without any abnormal CT findings such as intracranial hemorrhage, periventricular lucency was found in 65 cases (93%) and a wide extracerebral space of the temporal lobes was found in 60 cases (86%) before 44 weeks of gestation. A wide interhemispheric fissure was found in 11 cases of extremely premature infants before term. Periventricular lucency and a wide extracerebral space of temporal lobes may not be the result of the intracranial pathological changes, but they may represent a stage of brain development. 2) In 204 cases, intracranial hemorrhage was found in 39 cases; intra ventricular 14 cases, subependymal 2 cases, intracerebral 4 cases, subarachnoid 19 cases. CT was useful in evaluating the site and extent of hemorrhage. Among 14 cases of intraventricular hemorrhage, 9 cases ...
Cerebral blood flow measurement using stable xenon CT with very short inhalation times
Energy Technology Data Exchange (ETDEWEB)
A noninvasive, simplified method using inhalation of stable xenon (Xe{sup s}) and computed tomographic (CT) scanning to estimate regional cerebral blood flow (rCBF) and regional partition coefficient (r{lambda}) is described. Twenty-four patients with cerebrovascular occlusive disease and six volunteer controls inhaled 30% Xe{sup s} and 70% oxygen for 180 seconds and exhaled for 144 seconds during serial CT scanning without denitrogenation. The end-tidal Xe{sup s} concentration was continuously monitored with a thermoconductivity analyzer to determine the build-up range (A value) and build-up rate constant (K value) for arteries with the curve fitting method. The time-CT number (Hounsfield unit) curve for cerebral tissue during the Xe{sup s} washin and washout phases was used to calculate r{lambda} and rCBF using least squares curve fitting analysis. The resultant r{lambda} and rCBF map demonstrated a reliable distribution between the gray and ...
1991-02-01
Cerebral blood flow measurement using stable xenon CT with very short inhalation times
International Nuclear Information System (INIS)
A noninvasive, simplified method using inhalation of stable xenon (Xe"s) and computed tomographic (CT) scanning to estimate regional cerebral blood flow (rCBF) and regional partition coefficient (r#lambda#) is described. Twenty-four patients with cerebrovascular occlusive disease and six volunteer controls inhaled 30% Xe"s and 70% oxygen for 180 seconds and exhaled for 144 seconds during serial CT scanning without denitrogenation. The end-tidal Xe"s concentration was continuously monitored with a thermoconductivity analyzer to determine the build-up range (A value) and build-up rate constant (K value) for arteries with the curve fitting method. The time-CT number (Hounsfield unit) curve for cerebral tissue during the Xe"s washin and washout phases was used to calculate r#lambda# and rCBF using least squares curve fitting analysis. The resultant r#lambda# and rCBF map demonstrated a reliable distribution between the gray and white matter, and ...
Energy Technology Data Exchange (ETDEWEB)
This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a short period (7 days) of oral administration to mice, a nontoxic dose (0.1 g/kg) of HgS not only significantly enhanced pentobarbital-induced hypnosis but also attenuated tolerance induction; while a higher dose (1 g/kg) of HgS or cinnabar exerted an almost irreversible enhancing effect on pentobarbital-hypnosis similar to that of MeHg (2 mg/kg) tested, which was still effective even after 10 or 35 days cessation of administration. To study comparatively the effects of different mercury forms from oral administration of MeHg and HgS on membrane ATPase activities of experimental mice, analysis of the Hg content in the cerebral cortex revealed that ...
2008-06-15
Energy Technology Data Exchange (ETDEWEB)
In this thesis a study is made of the of voltage characteristics and reactive power control in the transmission network of the Electric Power Systems (EPS) with static compensators of VARs (SCVs). The necessity of voltage and reactive power control and the application of SCVs as a solution means for three representative operation stages of the EPS, considering balanced operation conditions and fundamental frequency is analyzed: Operation in the presence of incremental voltage changes, quasi-stationary operation or steady state and behavior at the occurrence of big disturbances. The application of SCVs to systems of integral transmission is in general a closed loop control system, reason why the analysis of the interaction of the system EPS-SCV is considered as an essential part of the voltage and reactive power control study. Firstly, the response analysis of the control loop is made for incremental voltage changes, representing the power ...
1987-07-01
International Nuclear Information System (INIS)
In summary, a scaling analysis of a water-cooled Reactor Cavity Cooling System (RCCS) system was performed based on generic information on the RCCS design of PBMR. The analysis demonstrates that the water-cooled RCCS can be simulated at the ANL NSTF facility at a prototypic scale in the lateral direction and about half scale in the vertical direction. Because, by necessity, the scaling is based on a number of approximations, and because no analytical information is available on the performance of a reference water-cooled RCCS, the scaling analysis presented here needs to be 'validated' by analysis of the steady state and transient performance of a reference water-cooled RCCS design. The analysis of the RCCS performance by CFD and system codes presents a number of challenges including: strong 3-D effects in the cavity and the RCCS tubes; simulation of turbulence in flows characterized by natural circulation, high Rayleigh numbers and low ...
International Nuclear Information System (INIS)
The construction materials used in coolant systems in nuclear power plants become covered with oxide films as a result of exposure to the aqueous environment. The susceptibility of the materials to different forms of corrosion, as well as the extent of the incorporation of radioactive species on the surfaces of the primary circuit, are greatly influenced by the physical and chemical properties of these oxide films. The composition and characteristics of the oxide films in turn depend on the applied water chemistry. This work was undertaken in order to collect and evaluate the present views on the structure and behaviour of oxide films formed on iron- and nickel-based materials in aqueous environments. This survey should serve to recognise the areas in which more understanding and research effort is needed. The review begins with a discussion on the bulk oxides of iron, nickel and chromium, as well as their mixed oxides. In addition to bulk oxides, the structure and properties of oxide ...
2010-03-01
Regulation of the pT181 encoded tetracycline resistance gene in Straphylococcus aureus
Energy Technology Data Exchange (ETDEWEB)
pT181 is a naturally-occurring 4437 basepair (bp) plasmid isolated from Staphylococcus aureus which encodes inducible resistance to tetracycline (Tc). The DNA sequence data has identified three open reading frames (ORFs). The largest ORF B, has been found to be responsible for the Tc resistance phenotype of pT181. Since most Tc resistance systems appear to be regulated by an effector protein and a repressor protein, several Bal 31 deletion mutants of pT181 were constructed and analyzed in an effort to identify the elements involved in Tc resistance. Two transcomplementing groups of mutants were identified within the tet gene. The mechanism of Tc resistance was studied by assaying the accumulation of (7-/sup 3/H) Tc by Tc sensitive cells, and uninduced and induced pT181-containing cells. A sharp decrease in accumulation of the drug after an initial increase was observed in Tc induced pT181-containing cells. In vivo labeling of Bacillus subtilis minicells containing pT181 was performed ...
1986-01-01
Energy Technology Data Exchange (ETDEWEB)
The CASTOC project addresses environmentally assisted cracking (EAC) phenomena in low alloy steels used for pressure boundary components in both Western type boiling water reactors (BWR) and Russian type pressurised water reactors (VVER). It comprises the four work packages (WP): inter-laboratory comparison test (WP1); EAC behaviour under static load (WP2), EAC behaviour under cyclic load and load transients (WP3); evaluation of the results with regard to their relevance for components in practice (WP4). The use of sophisticated test facilities and measurement techniques for the on-line detection of crack advances have provided a more detailed understanding of the mechanisms of environmentally assisted cracking and provided quantitative data of crack growth rates as a function of loading events and time, respectively. The effect of several major parameters controlling EAC was investigated with particular emphasis on the transferability of the results to components in service. The ...
2004-07-01
International Nuclear Information System (INIS)
Liquid Zone Control (LZC) System is a 'first-of-its-kind' reactivity control device, designed and implemented at TAPP-3 and 4. The system provides zonal and bulk power control. The system consists of fourteen Zone Control Compartments (ZCCs) containing demineralised light water as neutron absorber. Reactivity control is achieved by varying the level of water in the compartments bi-directionally. Six in-core zircaloy assemblies, housing the fourteen ZCCs and an elaborate process system constitute the LZC system. Measurement of water levels in the ZCCs is done using helium bubbler method. Reliability of ZCC water level measurement is of paramount importance. Commissioning and operating the new system trouble free was a challenge, considering the complex nature of the system. While commissioning the system, level measurement of one of the ZCCs (ZCC - 1) was found erratic and inconsistent. Methodologies were developed to identify the problem and investigations revealed leakage of helium ...
2006-11-13
CFD investigation of balcony spill plumes in atria (part II)
Energy Technology Data Exchange (ETDEWEB)
This paper proposes an integrated method for using experimental data and CFD modeling to develop engineering correlations for atrium smoke management. Part I focused on the experimental program and validation of a CFD model of the experimental facility. Part II describes the extension of this model to a parametric study of balcony spill plumes. Smoke management in buildings during fire events often uses mechanical ventilation systems to maintain smoke layer elevation above a safe evacuation path. Design of these systems requires accurate correlations for the smoke production or mass flow rate of the buoyant fire plume. One design issue is the mass flow rate of fire plumes which spill out from a fire compartment, under a balcony and up through an atrium or other large volume. Current engineering correlations for these balcony spill plumes (BSPs) are based on a combination of one-tenth scale test data and theoretical analysis. The suitability of these correlations for real-scale designs ...
2005-07-01
CFD investigation of balcony spill plumes in atria (part II)
International Nuclear Information System (INIS)
This paper proposes an integrated method for using experimental data and CFD modeling to develop engineering correlations for atrium smoke management. Part I focused on the experimental program and validation of a CFD model of the experimental facility. Part II describes the extension of this model to a parametric study of balcony spill plumes. Smoke management in buildings during fire events often uses mechanical ventilation systems to maintain smoke layer elevation above a safe evacuation path. Design of these systems requires accurate correlations for the smoke production or mass flow rate of the buoyant fire plume. One design issue is the mass flow rate of fire plumes which spill out from a fire compartment, under a balcony and up through an atrium or other large volume. Current engineering correlations for these balcony spill plumes (BSPs) are based on a combination of one-tenth scale test data and theoretical analysis. The suitability of these correlations for real-scale designs ...
CFD investigation of balcony spill plumes in atria
Energy Technology Data Exchange (ETDEWEB)
Smoke management in buildings during fire events often uses mechanical ventilation systems to maintain smoke layer elevation above a safe evacuation path. Design of these systems requires accurate correlations for the smoke production rate of the buoyant fire plume. One design issue is the smoke production rate of fire plumes which spill out from a fire compartment, under a balcony and up through an atrium or other large volume. Current engineering correlations for these balcony spill plumes are based on a combination of one-tenth scale test data and theoretical analysis. Questions have arisen over the suitability of these correlations for real-scale designs. A combined program of full-scale experimentation and CFD modeling is being conducted to analyze the accuracy of these correlations. A full-scale experimental facility was constructed with a 5 m by 5 m by 15 m fire compartment connected to a four-story atrium. Propane fires in the compartment produce balcony spill plumes which form ...
2004-07-01
CFD investigation of balcony spill plumes in atria
International Nuclear Information System (INIS)
Smoke management in buildings during fire events often uses mechanical ventilation systems to maintain smoke layer elevation above a safe evacuation path. Design of these systems requires accurate correlations for the smoke production rate of the buoyant fire plume. One design issue is the smoke production rate of fire plumes which spill out from a fire compartment, under a balcony and up through an atrium or other large volume. Current engineering correlations for these balcony spill plumes are based on a combination of one-tenth scale test data and theoretical analysis. Questions have arisen over the suitability of these correlations for real-scale designs. A combined program of full-scale experimentation and CFD modeling is being conducted to analyze the accuracy of these correlations. A full-scale experimental facility was constructed with a 5 m by 5 m by 15 m fire compartment connected to a four-story atrium. Propane fires in the compartment produce balcony spill plumes which form ...
2004-05-09
The similarity of twin brains; Die Aehnlichkeit von Zwillingsgehirnen
Energy Technology Data Exchange (ETDEWEB)
To test the assumption underlying every morphometric twin study that the brains of monozygotic twins are almost identical. Methods: High resolution MRI of the neurocranium of 26 monozygotic twin pairs were acquired and the volumes of 36 cerebral structures were measured. The same twins served as control group after rear-ranging them into non-related pairs of same sex and matching them for age, body height and body weight. Results: For most of the examined structures the correlations within the twins were significant (R = 0,97-0,59). Except for total forebrain volume the controls showed no significant similarity. Conclusions: For almost every measured cerebral structure the assumption, that significant similarities exist between healthy monozygotic twins is correct. Therefore discordant monozygotic twins represent an excellent sample when investigating cerebral correlates of neurologic and psychiatric disorders. (orig.) ...
2001-06-01
International Nuclear Information System (INIS)
The aim of this report was to assess the usefulness of cerebral blood flow (CBF) scanning utilising the SPECT technique in forensic medicine cases in the area of civil law cases. CBF SPECT scanning was performed in four patients utilising "9"9"mTc-ECD and a triple-head gammacamera. In the analysis both the asymmetry index and cerebellar normalisation were applied. Reference values were obtained by studying 30 healthy volunteers. In those cases CBF SPECT scanning played an important role in forensic argument. It influenced the sentence and the amount of financial compensation. CBF SPECT scanning may provide valuable information in forensic medicine argument in civil law cases, but only when taken together with psychometric tests and other neuroimaging methods (CT, MRI). The value of CBF SPECT scanning alone may be limited in judicial proceedings. (author)
Striatal dysfunction in attention deficit and hyperkinetic disorder
Energy Technology Data Exchange (ETDEWEB)
We have previously reported that periventricular structures are hypoperfused in attention deficit and hyperactivity disorder (ADHD). This study has expanded the number of patients, who were divided into two groups: six patients with pure ADHD, and 13 patients with ADHD in combination with other neurologic symptoms. By using xenon 133 inhalation and emission tomography, the regional cerebral blood flow distribution was determined and compared with a control group. Striatal regions were found to be hypoperfused and, by inference, hypofunctional in both groups. This hypoperfusion was statistically significant in the right striatum in ADHD, and in both striatal regions in ADHD with other neuropsychologic and neurologic symptoms. The primary sensory and sensorimotor cortical regions were highly perfused. Methylphenidate increased flow to striatal and posterior periventricular regions, and tended to decrease flow to primary sensory regions. Low striatal activity, ...
1989-01-01
Potential new approaches for the development of brain imaging agents for single-photon applications
International Nuclear Information System (INIS)
This paper describes new strategies for the brain-specific delivery of radionuclides that can be used to evaluate regional cerebral perfusion by single photon imaging techniques. A description of several examples of interesting new strategies that have recently been reported is presented. A new approach at this institution for the brain-specific delivery of radioiodinated iodophenylalkyl-substituted dihyronicotinamide systems is described which shows good brain uptake and retention in preliminary studies in rats. Following transport into the brain these agents appear to undergo facile intracerebral oxidation to the quaternized analogues which do not recross the intact blood-brain barrier and so are effectively trapped in the brain. 49 refs., 9 figs., 1 tab.
1984-10-12
Potential new approaches for the development of brain imaging agents for single-photon applications
International Nuclear Information System (INIS)
The goals of this paper are to describe new strategies being pursued at several institutions for the brain-specific delivery of radionuclides that can be used to evaluate regional cerebral perfusion by single photon imaging techniques. A comprehensive review of the literature is beyond the scope of these proceedings and our goal is to, therefore, present a description of several examples of interesting new strategies that have recently been reported. In addition, the authors also describe a new approach being pursued at their institution for the brain-specific delivery of radioiodinated iodophenylaklyl-substituted dihydronicotiamide systems which shows good brain uptake and retention in preliminary studies in rats. Following transport into the brain these agents appear to undergo facile intracerebral oxidation to the quaternized analogues which do not cross the intact blood-brain-barrier and are effectively trapped in the brain.
Effect of Tong Luo Jiu Nao on Ab-degrading enzymes in AD rat brains
British Library Electronic Table of Contents (United Kingdom)
Ethnopharmacological relevance: Tong Luo Jiu Nao (TLJN) is a modern Chinese formula based on Traditional Chinese Medicine theory that has been used to treat ischemic cerebral stroke and vascular dementia. TLJN belongs to the ethnopharmacological family of medicines. In this study, we investigated the mechanism of the TLJN effect on Alzheimer's disease (AD). Aim of the study: To investigate the effect of TLJN on b-amyloid-degrading enzymes and learning and memory in the AD rat brain. Materials and methods: AD rats whose disease was induced by Ab25-35 injection into the bilateral hippocampus CA1 region were subjected to intragastric administration of various preparations. The experimental animals were healthy male Sprague-Dawley rats which were randomly divided into normal, sham, model, TLJN...
2011-01-01
British Library Electronic Table of Contents (United Kingdom)
Nitric oxide (NO) is a gas produced through the action of nitric oxide synthase that acts as a neurotransmitter in the central nervous system (CNS) of adult gastropod mollusks. There are no known reports of the presence of NOS-containing neurons and glial cells in young and adult Megalobulimus abbreviatus. Therefore, NADPH-d histochemistry was employed to map the nitrergic distribution in the CNS of young and adult snails in an attempt to identify any transient enzymatic activity in the developing CNS. Reaction was observed in neurons and fibers in all CNS ganglia of both age groups, but in the pedal and cerebral ganglia, positive neurons were more intense than in other ganglia, forming clusters symmetrically located in both paired ganglia. However, neuronal NADPH-d activity in the mesocer...
2010-01-01
British Library Electronic Table of Contents (United Kingdom)
Thioredoxin reductase (TrxR) isoforms play important roles in cell physiology, protecting cells against oxidative processes. In addition to its endogenous substrates (Trx isoforms), hepatic TrxR can reduce organic selenium compounds such as ebselen and diphenyl diselenide to their selenol intermediates, which can be involved in their hepatoprotective properties. Taking this into account, the aim of the present study was to evaluate the hypothesis that ebselen, diphenyl diselenide and its analogs (4,4'-bistrifluoromethyldiphenyl diselenide, 4,4'-bismethoxydiphenyl diselenide, 4.4'-biscarboxy-diphenyl diselenide, 4,4'-bischlorodiphenyl diselenide, 2,4,6,2',4',6'-hexamethyldiphenyl diselenide) could be substrates of rat brain TrxR. In the presence of partially purified rat brain TrxR, dipheny...
2011-01-01
British Library Electronic Table of Contents (United Kingdom)
Cognitive decline has been described in elderly patients with schizophrenia, but the underlying pathology remains unknown. Some studies report increases in plaques and neurofibrillary tangles, but there is no evidence for an increased risk for Alzheimer's disease (AD) in elderly schizophrenics. Models of a decreased cerebral reserve suggest that increases in AD-related neuropathology below the threshold for a neuropathological diagnosis could be related to dementia severity in elderly schizophrenia patients. We tested this hypothesis in 110 autopsy specimens of schizophrenia patients, without a neuropathological diagnosis of AD or other neurodegenerative disorders. Furthermore, we assessed the effects of apolipoprotein E (ApoE) status, a known genetic risk factor for AD. Measures of densit...
2010-01-01
British Library Electronic Table of Contents (United Kingdom)
Abstract The brain is highly sensitive to environmental hypoxia. Little is known, however, about the neuropsychological effects of high altitude residence in the developing brain. We recently described only minor changes in processing speed in native Bolivian children and adolescents living at approximately 3700-m. However, evidence for loss of cerebral autoregulation above this altitude (4000-m) suggests a potential threshold of hypoxia severity over which neuropsychological functioning may be compromised. We conducted physiological and neuropsychological assessments in 62 Bolivian children and adolescents living at La Paz (-3700-m) and El Alto (-4100-m) in order to address this issue. Groups were equivalent in terms of age, gender, social class, schooling, parental education and genetic ...
2011-01-01
Birth Weight and Health and Developmental Outcomes in US Children, 1997?2005
British Library Electronic Table of Contents (United Kingdom)
The primary goal of this study was to assess the association between the full birth weight distribution and prevalence of specific developmental disabilities and related measures of health and special education services utilization in US children. Using data from the 1997?2005 National Health Interview Survey (NHIS) Sample Child Core, we identified 87,578 children 3?17?years of age with parent-reported information on birth weight. We estimated the prevalences of DDs (attention-deficit/hyperactivity disorder [ADHD], autism, cerebral palsy, hearing impairment, learning disability without mental retardation, mental retardation, seizures, stuttering/stammering, and other developmental delay) and several indicators of health services utilization within a range of birth weight categories. We cal...
2011-01-01
British Library Electronic Table of Contents (United Kingdom)
All patients with von Willebrand?s disease (vWD) who showed an arterial or venous thrombosis and were reported in the literature have been evaluated. 11 patients had arterial thrombosis while 19 had venous thrombosis for a total of 30 cases. 9 out the 11 cases with arterial thrombosis had myocardial infarction. Two had cerebral thrombosis. Associated risk factors for arterial thrombosis were available only for three patients who showed, respectively, smoking and dyslipidemia (2 cases) and smoking and intravenous desmopressin infusion (1 case). The majority of patients with venous thrombosis showed DVT with or without PE. Four patients presented with apparently isolated PE. In two instances thrombosis occurred in unusual sites (central retinal vein and portal vein, respectively). Several as...
2006-01-01
A model of a self-oscillatory process involving elements discretely distributed in space
Self-excited oscillations of a distributed medium can be investigated in terms of discrete physical models described by multidimensional systems of nonlinear equations which transform into equations of self-oscillating distributed media as the number of dimensions goes to infinity. Differential equations of such a self-oscillating system are set up and investigated. Coupling between elements of the medium, conditions under which the system constitutes an open system, internal impedance between the energy source and the system elements, and boundary conditions defining open and closed systems are discussed. The Gunn effect, eolian noise, self-oscillations of DNA molecules and of cardiac muscle, and wave processes in the cerebral cortex are mentioned as examples of self-oscillatory processes in question.
1975-01-01
Energy Technology Data Exchange (ETDEWEB)
Purpose: Cardiomyopathy is one of the major complications of {beta} thalassaemia major as a result of transfusion iron overload. The aim of our study is to evaluate with MR if there is any difference of iron deposition signal intensity (SI) or distribution between non-cardiopatic and cardiopatic thalassaemic patients in order to establish if there is a relationship between cardiopathy and iron deposition. Materials and methods: We studied 20 patients affected by {beta} thalassaemia major, of whom 10 cardiopatic and 10 non-cardiopatic, and 10 healthy volunteers as control group. Serum ferritin and left ventricular ejection fraction were calculated in thalassaemic patients. All patients were examinated using a 1.5 MR unit with ECG-gated GE cine-MR T2*-weighted, SE T1-weighted and GE T2*-weighted sequences. In all cases, using an adequate ROI, the myocardial and skeletal muscle signal intensity (SI), the myocardial/skeletal ...
2005-02-01
Time course of radiolabeled 2-deoxy-D-glucose 6-phosphate turnover in cerebral cortex of goats
Energy Technology Data Exchange (ETDEWEB)
The vivo dephosphorylation rate of 2-deoxy-D-glucose 6-phosphate (DGP) in the cerebral cortex of goats injected intravenously with radiolabeled 2-deoxy-D-glucose (DG) was investigated. Serial rapidly frozen samples of parietal cortical gray tissue were obtained at regular intervals over time periods from 45 min to 3 h in awake goats or in paralyzed and artificially ventilated goats maintained under 70% N/sub 2/O or pentobarbital sodium anesthesia. The samples were analyzed for glucose content and separate DG and DGP activities. The rate parameters for phosphorylation (k/sup *//sub 4/) and dephosphorylation (k/sup *//sub 4/) were estimated in each animal. The glucose phosphorylation rate (PR) was calculated over the intervals 3-5 (or 6), 3-10, 3-20, 3-30, and 3-45 min, assuming k/sup *//sub 4/ = O. As the evaluation period was extended beyond 10 min, the calculated PR became increasingly less when compared with that calculated over the 3- to 5- (or 6) min interval ...
1987-02-01
Nuclear Medicine Program progress report for quarter ending September 30, 1992
Energy Technology Data Exchange (ETDEWEB)
The radioiodination and in vivo evaluation of p-iodocaramiphen a muscarinic antagonist which binds with high affinity to the M[sub 1] receptor subtype in vitro are described. Biodistribution studies in female Fischer rats demonstrated that [[sup 125]I]-piodocaraminphen had significant cerebral localization, but the uptake did not demonstrate specific uptake in those cerebral regions rich in muscarinic receptors, and radioactivity washed out rapidly from the brain. In addition there was no significant blockage of activity when the rats were preinjected with quinuclidinyl benzilate. These results suggest that p-iodocaramiphen is not a good candidate for the in vivo study of M[sub 1] muscarinic receptor populations by SPECT. Because of the widespread interest and expected importance of the availability of large amounts of tungsten-188 required for the tungsten-188/rhenium-188 generator systems, we have investigated the large-scale production of ...
1992-12-01
Magnetic resonance imaging of cerebral anomalies in subjects with resistance to thyroid hormone
Energy Technology Data Exchange (ETDEWEB)
Resistance to thyroid hormone (RTH) is an autosomal dominant disease caused by mutations in the human thyroid receptor beta gene on chromosome 3. Individuals with RTH have an increased incidence of attention deficit hyperactivity disorder (ADHD). The purpose of this study was to search for developmental brain malformations associated with RTH. Forty-three subjects (20 affected males [AM], 23 affected females [AF]) with resistance to thyroid hormone and 32 unaffected first degree relatives (18 unaffected males [UM], 14 unaffected females [UF]) underwent MRI brain scans with a volumetric acquisition that provided 90 contiguous 2 mm thick sagittal images. Films of six contiguous images beginning at a standard sagittal position lateral to the insula were analyzed by an investigator who was blind with respect to subject characteristics. The presence of extra or missing gyri in the parietal bank of the Sylvian fissure (multimodal association cortex) and multiple Heschl`s transverse gyri ...
1995-06-19
Energy Technology Data Exchange (ETDEWEB)
A study was made of the actions of the excitant neurotoxin, kainic acid, on the uptake and the release of D-(2,3-3H)aspartate (D-ASP) in slices of guinea pig cerebral neocortex and striatum. The slices took up D-ASP, reaching concentrations of the amino acid in the tissue which were 14-23 times that in the medium. Subsequently, electrical stimulation of the slices evoked a Ca2+-dependent release of a portion of the D-ASP. Kainic acid (10(-5)-10(-3) M) produced a dose-dependent inhibition of D-ASP uptake. The electrically evoked release of D-ASP was increased 1.6-2.0 fold by 10(-5) and 10(-4)M kainic acid. The kainate-enlarged release was Ca2+-dependent. Dihydrokainic acid, an analogue of kainic acid with little excitatory or toxic action, did not increase D-ASP release but depressed D-ASP uptake. Attempts were made to block the action of kainic acid with baclofen and pentobarbital, compounds which depress the electrically evoked release of L-glutamate (L-GLU) and ...
1983-06-01
Hypercapnic normalization of BOLD fMRI: comparison across field strengths and pulse sequences.
DEFF Research Database (Denmark)
The blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal response to neural stimulation is influenced by many factors that are unrelated to the stimulus. These factors are physiological, such as the resting venous cerebral blood volume (CBV(v)) and vessel size, as well as experimental, such as pulse sequence and static magnetic field strength (B(0)). Thus, it is difficult to compare task-induced fMRI signals across subjects, field strengths, and pulse sequences. This problem can be overcome by normalizing the neural activity-induced BOLD fMRI response by a global hypercapnia-induced BOLD signal. To demonstrate the effectiveness of the BOLD normalization approach, gradient-echo BOLD fMRI at 1.5, 4, and 7 T and spin-echo BOLD fMRI at 4 T were performed in human subjects. For neural stimulation, subjects performed sequential finger movements at 2 Hz, while for global stimulation, subjects breathed a 5% CO(2) gas mixture. Under ...
2004-01-01
Energy Technology Data Exchange (ETDEWEB)
We examined the abnormalities of regional cerebral blood flow(rCBF) in children with attention deficit hyperactivity disorder(ADHD) without comorbidity using statistical parametric mapping(SPM) method. We used the patients with not compatible to DSM-IV diagnostic criteria of ADHD and normal rCBF pattern in visual analysis as normal control children. Tc-99m ECD brain SPECT was performed on 75 patients (M:F=64:11, 10.0{+-}2.5y) with the DSM-IV diagnostic criteria of ADHD and 13 normal control children (M:F=9:4, 10.3{+-}4.1y). Using SPM method, we compared patient group's SPECT images with those of 13 control subjects and measured the extent of the area with significant hypoperfusion(p<0.01) in predefined 34 cerebral regions. Only on area of left temporal lobe showed significant hypoperfusion in ADHD patients without comorbidity (n=75) compared with control subjects(n=13). (n=75, p<0.01, extent threshold=16). rCBF of left ...
2002-07-01
Functional magnetic resonance imaging of the normal and abnormal visual system in early life.
DEFF Research Database (Denmark)
Functional magnetic resonance imaging (fMRI) in young children may provide information about the development of the visual cortex, and may have predictive value for later visual performance. The purpose of this study was to evaluate the usefulness of fMRI for examining cerebral processing of vision in very young infants and in infants with brain damage. We examined 15 preterm infants, 12 children suspected of having a cerebral visual impairment and 10 children with a normal visual system, all of whom were either spontaneously asleep or sedated with chloral hydrate. Cortical response to stroboscopic light stimulation could be demonstrated in all technically acceptable data sets from children with a post-menstrual age (PMA) of > 41 weeks, but not in younger infants. Children < 60 weeks PMA showed either a blood oxygenation level-dependent (BOLD) signal increase or decrease, while all older children showed a signal decrease. The activated ...
2000-01-01
International Nuclear Information System (INIS)
The concentration of trace elements in brain sections was measured by synchrotron radiation X-ray fluorescence. The relative concentration was calculated by means of the normalization of Compton scattering intensity approximately 22 keV, after the normalization for collecting time of X-ray spectrum and the counting of the ion chamber, and subtracting the contribution of the polycarbonate film for supporting sample. Furthermore, the statistical evaluation of the element distribution in various regions of the brain sections of the 20-day-old rats was tested. For investigating the distribution of elements in the brain of iodine deficient rats, Wistar rats were fed with iodine deficient diet and deionized water (ID group). The rats were fed the same iodine deficient diet, but drank KIO_3 solution as control (CT group). The results showed that the contents of calcium (Ca) in thalamus (TH) and copper (Cu) and iron (Fe) in cerebral cortex (CX) of ID rats were ...
2004-02-27
Development of regional cerebral blood flow during childhood studied with Iodine-123-IMP SPECT
International Nuclear Information System (INIS)
Regional cerebral blood flow (rCBF) was assessed with single photon emission computed tomography (SPECT), "1"2"3I-N-isopropyl-iodoamphetamine ("1"2"3I-IMP), and the Table-Look-Up method in 51 children (27 boys, 24 girls) considered neurologically normal and aged 1 month to 15 years (mean age, 4 years 1 month; standard deviation (SD) 3 years 11 months) divided into seven age groups. The rCBF was measured in cortical regions, the cerebellum, thalamus, and the head of the caudate nucleus. Curves for reference values and standard deviations were defined for each region. The rCBF rapidly increased until 2 years of age, reaching maximum values during the third to fifth periods (2 to 10 years of age) in each region. The rCBFs then decreased, reaching adult levels at 10 to 15 years of age. The rCBF reached maximum values later in the frontal region than in other regions. The rCBF during the early period increased most prominently in the occipital region. These results ...
2006-06-01
International Nuclear Information System (INIS)
The influence of carbon monoxide (CO) exposure on regional cerebral blood flow (r-CBF) in rat brain was studied using autoradiography and "1"2"5I-IMP. Fuji computed radiography (FCR) was used to obtain improved autoradiograms in this study. R-CBF was determined in a relative measure by calculating hippocampus/cortex and putamen/cortex ratios of RI accumulation from the autoradiogram using a densitometer. Comparison of autoradiograms with pathological findings in the area of the hippocampus and putamen yield the following results. In the animals that were exposed to 6400 ppm or 10000 ppm of CO for 30 minutes, and then were followed up for 2 weeks without further exposure, r-CBF was decreased but no pathological changes occurred. In the animals that were exposed to 6400 ppm or 10000 ppm of CO, and then were followed up for 4 weeks without further exposure, pathological changes appeared. In animals exposed to 3200 ppm of CO, the r-CBF tended to recover after 4 weeks. ...
Energy Technology Data Exchange (ETDEWEB)
The influence of carbon monoxide (CO) exposure on regional cerebral blood flow (r-CBF) in rat brain was studied using autoradiography and {sup 125}I-IMP. Fuji computed radiography (FCR) was used to obtain improved autoradiograms in this study. R-CBF was determined in a relative measure by calculating hippocampus/cortex and putamen/cortex ratios of RI accumulation from the autoradiogram using a densitometer. Comparison of autoradiograms with pathological findings in the area of the hippocampus and putamen yield the following results. In the animals that were exposed to 6400 ppm or 10000 ppm of CO for 30 minutes, and then were followed up for 2 weeks without further exposure, r-CBF was decreased but no pathological changes occurred. In the animals that were exposed to 6400 ppm or 10000 ppm of CO, and then were followed up for 4 weeks without further exposure, pathological changes appeared. In animals exposed to 3200 ppm of CO, the r-CBF tended to recover after 4 ...
1990-11-01
A revised dosimetric model of the adult head and brain
Energy Technology Data Exchange (ETDEWEB)
During the last decade, new radiopharmaceutical have been introduced for brain imaging. The marked differences of these tracers in tissue specificity within the brain and their increasing use for diagnostic studies support the need for a more anthropomorphic model of the human brain and head. Brain and head models developed in the past have been only simplistic representations of this anatomic region. For example, the brain within the phantom of MIRD Pamphlet No. 5 Revised is modeled simply as a single ellipsoid of tissue With no differentiation of its internal structures. To address this need, the MIRD Committee established a Task Group in 1992 to construct a more detailed brain model to include the cerebral cortex, the white matter, the cerebellum, the thalamus, the caudate nucleus, the lentiform nucleus, the cerebral spinal fluid, the lateral ventricles, and the third ventricle. This brain model has been included within a slightly modified ...
1996-06-01
A revised dosimetric model of the adult head and brain
International Nuclear Information System (INIS)
During the last decade, new radiopharmaceutical have been introduced for brain imaging. The marked differences of these tracers in tissue specificity within the brain and their increasing use for diagnostic studies support the need for a more anthropomorphic model of the human brain and head. Brain and head models developed in the past have been only simplistic representations of this anatomic region. For example, the brain within the phantom of MIRD Pamphlet No. 5 Revised is modeled simply as a single ellipsoid of tissue With no differentiation of its internal structures. To address this need, the MIRD Committee established a Task Group in 1992 to construct a more detailed brain model to include the cerebral cortex, the white matter, the cerebellum, the thalamus, the caudate nucleus, the lentiform nucleus, the cerebral spinal fluid, the lateral ventricles, and the third ventricle. This brain model has been included within a slightly modified ...
1996-07-21
Phase I Report: DARPA Exoskeleton Program
The Defense Advanced Research Projects Agency (DARPA) inaugurated a program addressing research and development for an Exoskeleton for Human Performance Augmentation in FY!2001. A team consisting of Oak Ridge National Laboratory, the prime contractor, AeroVironment, Inc., the Army Research Laboratory, the University of Minnesota, and the Virginia Polytechnic Institute has recently completed an 18-month Phase I effort in support of this DARPA program. The Phase I effort focused on the development and proof-of-concept demonstrations for key enabling technologies, laying the foundation for subsequently building and demonstrating a prototype exoskeleton. The overall approach was driven by the need to optimize energy efficiency while providing a system that augmented the operator in as transparent manner as possible (non-impeding). These needs led to the evolution of two key distinguishing features of this team's approach. The first is the ''no knee ...
2004-01-21
Multiphase reacting flow modeling of singlet oxygen generators for chemical oxygen iodine lasers.
Energy Technology Data Exchange (ETDEWEB)
Singlet oxygen generators are multiphase flow chemical reactors used to generate energetic oxygen to be used as a fuel for chemical oxygen iodine lasers. In this paper, a theoretical model of the generator is presented along with its solutions over ranges of parameter space and oxygen maximizing optimizations. The singlet oxygen generator (SOG) is a low-pressure, multiphase flow chemical reactor that is used to produce molecular oxygen in an electronically excited state, i.e. singlet delta oxygen. The primary product of the reactor, the energetic oxygen, is used in a stage immediately succeeding the SOG to dissociate and energize iodine. The gas mixture including the iodine is accelerated to a supersonic speed and lased. Thus the SOG is the fuel generator for the chemical oxygen iodine laser (COIL). The COIL has important application for both military purposes--it was developed by the US Air Force in the 1970s--and, as the infrared beam is readily absorbed by metals, industrial cutting ...
2008-08-01
Energy Technology Data Exchange (ETDEWEB)
This study follows previous experimental work showing that the shrinking-core model applies to the pyrolysis (i.e., heating in the absence of oxygen) of particles (diam.{approx}14 mm) of a bituminous coal or a lignite in a fluidized bed at 700-950 {sup o}C. These experimental facts are in accord with the production of volatile matter being endothermic and not thermoneutral, as often assumed. Also, the rate at which volatile matter is produced in the presence of oxygen (i.e., devolatilization) or in its absence (pyrolysis) is demonstrated here to be controlled not at all by mass transfer, but by heat conduction to a moving reaction front inside a coal particle, provided its diameter exceeds {approx}3 mm. The resulting steady-state model of devolatilization indicates that six dimensionless groups are required to describe the rate of(I)coal->char+volatile matter for a nonfragmenting and nonswelling coal. This reaction occurs for a total time of c{sub 1}r{sub ...
2006-08-15
[Natriuretic peptides--relevance in intensive care].
The family of natriuretic peptides consists of the atria natriuretic peptide (ANP), the cerebral natriuretic peptide (BNP), the type C natriuretic peptide (CNP) and the peptide isolated from the dendroaspis snakes' poison (DNP), whose presence in humans has not been confirmed. The physiological function of ANP is in the control of arterial blood pressure by regulation of systemic vascular resistance of blood vessels. BNP is produced as one of the factors in the acute response to inflammatory tissue damage, mainly in coronary vessels. Increased serum concentrations of natriuretic peptides have been found in stress situations, such as trauma or major surgery, systemic hypotension, and in intrinsic myocardial dysfunction. High concentrations of natriuretic peptides were observed in severe sepsis, septic shock and in multiple organ failure, probably due to increased secretion by mediators of the inflammatory process.The highest concentrations of ANP and BNP were found ...
Ultra high field magnetic resonance imaging
International Nuclear Information System (INIS)
Understanding human brain function, brain development and brain dysfunction is one of the great challenges of the twenty first century. Biomedical imaging has now run up against a number of technical constraints that are exposing limits to its potential. In order to overcome the current limits to high-field magnetic resonance cerebral imaging (MRI) and unleash its fullest potential, the Cea has built NeuroSpin, an ultra-high-field neuroimaging facility at its Saclay centre (in the Essonne). NeuroSpin already boasts three fully operational MRI systems. The first is a 3-tesla high-field system and the second is a very-high-field 7-tesla system, both of which are dedicated to clinical studies and investigations in humans, while the third is an ultra-high-field 17.65-tesla system designed for studies on small animals. In 2011, NeuroSpin will be commissioning an 11.7-tesla ultra-high-field system of unprecedented power that is designed for research on human subjects. ...
Stent-assisted recanalization of atherosclerotic intracranial stenosis
International Nuclear Information System (INIS)
Intracranial atherosclerosis is a major cause of ischemic stroke, and depending on the studied population, it accounts for 8%-15% of all strokes that are due to cerebral atherosclerosis. The prognosis of patients with symptomatic intracranial stenoses seems to depend on the location and extent of intracranial atherosclerosis. Currently, the primary treatment in intracranial atherosclerosis is the control of vascular risk factors such as hypertension, diabetes, hypercholesterolemia, and smoking. Secondary prevention with antiplatelet therapy has been shown to reduce the risk of subsequent vascular events in patients who have suffered a recent ischemic stroke or transient ischemic attack (TIA). Unfortunately, a significant number of patients with intracranial atherosclerosis continue to suffer from repeated strokes or TIA despite maximal medical treatment. Although endovascular revascularization for symptomatic intracranial stenoses remains at the investigational ...
2006-09-01
International Nuclear Information System (INIS)
Intrathecal _1_9_8Au colloid and methotrexate were administered to 27 children (between 1972 and 1981) with non-lymphatic leukaemia, 21 with non-Hodgkin lymphoma and two with Ewing's sarcoma to prevent CNS involvement. In one boy with non-lymphatic leukaemia a stable remission after a three-year period of cytostatic treatment ended with isolated CNS involvement. No isolated CNS recurrence occurred in children with non-Hodgkin lymphoma receiving regular radiogold administration. Combined iris and CNS recurrence occurred in one child with non-Hodkin lymphoma. Eleven of 21 children with non-Hodgkin lymphoma have been in complete initial remission for 4-39 months without cytostatic treatment. Late cerebral complications have not been observed after _1_9_8Au colloid and methotrexate. (orig.).
Energy Technology Data Exchange (ETDEWEB)
The aim of this work is the evaluation of biodistribution and radiation dosimetry of a cocaine analog, the N-(3-iodo-prop-2E-enyl)-2beta-carbo-methoxy-3beta-(4-methyl-phenyl) nor-tropane (PE2I), labeled with carbon 11 ([{sup 11}C]PE2I). The [{sup 11}C]PE2I is a selective radioligand for imaging neuronal dopamine transporter (DAT) with positron emission tomography (PET). The DAT is a membrane-bound pre synaptically located protein that regulates the concentration of dopamine at nerve terminals. DAT radioligands are often used to evaluate the progression of Parkinson's disease or the efficiency of neuro-protective therapeutics and, typically, these studies required several successive PET scans. (author)
2005-10-15
International Nuclear Information System (INIS)
This study aimed to reveal that severe disturbance of attachment relationship with primary care-giver can affect functional and anatomical brain development by measuring cerebral perfusion on "9"9"mTc-ECD brain SPECT and correlative MRI. We included 18 children aged 31 to 76 months who met the diagnostic criteria of RAD as defined in DSM-IV and ICD-10 and SSP and CARS. "9"9"mTc-ECD SPECT was performed using CERASPECT. MRI was performed in all patients. SPECT data were visually assessed. 15 of 18 children had abnormal perfusion on SPECT, revealing decreased perfusion of Lt.thalamus (7/15) and Rt.thalamus (3/15), and bilateral thalami (5/15). Perfusion of basal ganglia was decreased in 8 children. Decreased perfusion of Lt. parietal area was seen in 2. Whereas, all patients had normal MR findings. Perfusion abnormalities involving thalamus, BG in most children with RAD were found in this study. These results suggest that brain development of infant could be impeded ...
2002-11-15
Normal and abnormal water diffusion in the brain
International Nuclear Information System (INIS)
Diffusion magnetic resonance imaging (MRI) has become an important tool in the radiologic diagnosis of diseases of the brain as it measures molecular motion of water that characterizes the microstructure of tissues. Its most important clinical use to date is the early detection of cerebral ischemia by revealing the ischemic injury shortly after vessel occlusion and simultaneously providing therapy-relevant information on the tissue at risk. Furthermore, diffusion MRI is diagnostically promising in other diseases of the brain and is thus increasingly becoming part of routine clinical protocols in the diagnosis of tumors, inflammation, trauma, demyelination, dysmyelination and neurodegeneration. Although abnormalities of diffusion are generally not pathognomonic, diffusion MRI affords information about tissue changes for specific disorders that complements information obtained with standard MR techniques and frequently shows pathology earlier. In addition, diffusion ...
2003-10-01
International Nuclear Information System (INIS)
Central Nervous System (CNS) involvement, whether primary by the Human Immunodeficiency Virus - HIV - itself, or secondary (toxoplasmosis or lymphoma) is remarkably frequent in AIDS, in 40 to 70% of cases, depending upon the author. In order to study the natural history of this illness, a cohort of 25 asymptomatic seropositive patients have been established. Every 6 months these patients undergo biological and clinical examinations, as well as Magnetic Resonance brain scans. After two examinations at a 6 month's interval, the first results are reported. Out of these 25 cases, 9 present anomalies: One patient with diffuse cerebral atrophy and 8 others with high signal intensity areas on T2 weighted sequences, like those of the Multiple Sclerosis. No relationship could be demonstrated between the existence of these lesions and various criteria such as age, sex, risk factors and T4 cells count. The nature of these lesions is not lear. They certainly indicate early ...
International Nuclear Information System (INIS)
We investigated the isotropic diffusion coefficient (D') and fractional anisotropy (FA) in white matter (WM) during brain development, using an optimised diffusion-tensor imaging (DTI) method with whole brain coverage in a clinically acceptable time. We images 52 children with no evident neurological abnormality (30 boys, 22 girls aged 1 day-16 years) using high-angle DTI with optimised temporal gradient performance. D' and FA were calculated in 10 regions of interest in white matter. We saw that the age-related reduction in D' and increase in FA follow a mono- or biexponential model in white matter, probably depending on the compactness and myelination rate of the fibre tracts. In contrast to other areas, in which adult values were reached during the third year, there is a trend to continuous increase in FA in all deep white-matter areas, suggesting continuing maturation and organisation of deep tracts not detected on conventional MRI. (orig.)
2004-04-01
Effects of anesthesia upon "1"8F-FDG uptake in rhesus monkey brains
International Nuclear Information System (INIS)
The kinetics of "1"8F-fluorodeoxyglucose ("1"8F-FDG) in the monkey brain were monitored, and comparisons were made between the conscious state and when under ketamine and pentobarbital anesthesia. Rhesus monkeys were intravenously injected with "1"8F-FDG and followed by 60 min of PET scanning. In the conscious state, the "1"8F-FDG concentration reached a plateau 5 min after intravenous injection. Under ketamine anesthesia, the "1"8F-FDG concentration gradually increased with time in all monitored regions. At 60 min after injection, the concentration in the striatum was about 3.2 times greater than that in the conscious state, and about 4.5 times greater in the cerebral cortex. Under pentobarbital anesthesia, the "1"8F-FDG concentration in the occipital cortex was slightly lower. These findings demonstrate that "1"8F-FDG concentration in the monkey brain is significantly affected by anesthesia. The results also imply the existence of a short-term regulation ...
2005-07-01
Computer assisted axial tomography (Emi scan) in neurologic investigation
Cerebral angiography, pneumoencephalography, and radioisotope brain scan with their differing diagnostic abilities have provided the neurologist and neurosurgeon with extremely valuable diagnostic techniques. It is doubtful, however, if any of these now conventional methods had the enormous impact on the practice of neurology that computer assisted axial tomography (C.A.T.) is beginning to have. Here, for the first time, is a test which, without significant risk or discomfort, can demonstrate some normal intracranial (and intraorbital) structures, can demonstrate some normal intracranial pathology and, in many cases, can make the potentially dangerous contrast studies unnecessary. After only a few months experience with C.A.T. in a clinical setting, it has become obvious that there will have to be a reappraisal of the accepted investigative work-up of many conditions. While it is too early to have formulated strict criteria for the use of C.A.T., this paper is an ...
1974-01-01
International Nuclear Information System (INIS)
The subjects covered in this Symposium range through almost every clinical medical specialty. From an average of one paper in each of the past three Symposiums, the explosive interest in cerebral amyloidosis has led to the presentation of 12 papers on this subject in the present volume. The genetically predisposed familial amyloidotic processes, such as the polyneuropathies and familial Mediterranean fever have also stimulated extensive and intriguing investigations which have revealed the striking effect of a single amino acid substitution in transforming a normal protein into a lethal ''amyloidogenic'' one. This Symposium clearly depicts the advances since the first amyloid fibril protein was definitively identified and defined 14 years ago. Since all amyloid fibril proteins so far described are variants of normal proteins, attention to gene abnormalities now becomes a significant focus as well as the pathogenic sequences which lead in these cases to twisted ...
1984-11-09
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