t1-2 n1-2 m0: Topics by WorldWideScience.org

Genome lability in radiation-induced transformants of C3H 10T1/2 mouse fibroblasts

Four /sup 125/I labeled mono- and diamines were prepared and evaluated as potential brain-imaging agents. The diamines are analogues of the previously reported /sup 75/Se labeled diamines, which show high brain uptake and retention. All of the radioiodinated amines display high initial brain uptake in rats after intravenous injection (1.7-2.4% dose/organ). The xylylenediamines show prolonged brain retention (t1/2 approximately 18 h), which is desirable for brain imaging. In contrast, the benzylamine is rapidly cleared from brain tissue (t1/2 approximately 15 min).

1982-07-01

Synthesis and tissue distribution study of iodine-labeled benzyl- and xylylamines

We have been investigating radiation-induced neoplastic transformants of C3H 10T1/2 mouse fibroblasts for evidence of heritable changes. C3H 10T1/2 cells were treated with 8 Gy X rays. After approximately 8 weeks of culture, type II/III foci were isolated from the monolayer using cloning rings. Cell lines developed from these foci, and clones established from these cell lines, were examined for DNA content. The isolated focus-derived populations and derived clones often display aneuploidy and/or polyploidization. In one instance a clone (derived from a single cell) displayed multiple polyploidies. During passage the ploidy of many of the anomalous populations gradually reverted to the ploidy of the non-neoplastically transformed state. The morphological features associated with the neoplastic transformation event were nevertheless retained. The results demonstrate that exposure to radiation can induce, ...

1994-04-01

Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes.

Four "1"2"5I labeled mono- and diamines were prepared and evaluated as potential brain-imaging agents. The diamines are analogues of the previously reported "7"5Se labeled diamines, which show high brain uptake and retention. All of the radioiodinated amines display high initial brain uptake in rats after intravenous injection (1.7-2.4% dose/organ). The xylylenediamines show prolonged brain retention (t1/2 approximately 18 h), which is desirable for brain imaging. In contrast, the benzylamine is rapidly cleared from brain tissue (t1/2 approximately 15 min).

UK PubMed Central (United Kingdom)

While a great deal of evidence has directly implicated the importance of O6-alkylation of guanine in the mutagenicity of alkylating agents, evidence demonstrating the oncogenic potential of this lesion...Full Text Available

1992-12-01

Poncirin promotes osteoblast differentiation but inhibits adipocyte differentiation in mesenchymal stem cells.

Measurement of the "1"0"9Cd half-life

Poncirin, flavanone glycoside, isolated from the fruit of Poncirus trifoliata, has anti-bacterial and anti-inflammatory activities. In this study, the effects of poncirin on the differentiation of mesenchymal stem cells were investigated. The C3H10T1/2 mesenchymal stem cells and primary bone marrow mesenchymal stem cells were studied. In the C3H10T1/2 cells, poncirin prevented adipocyte differentiation, as demonstrated by inhibition of cytoplasm lipid droplet accumulation and peroxisome proliferator-activating receptor-? (PPAR-?) and CCAAT-enhancer-binding protein-? (C/EBP-?) mRNA expression. By contrast, poncirin enhanced the expression of the key osteogenic transcription factors, runt-related transcription factor 2 (Runx2) and transcriptional coactivator with PDZ-binding motif (TAZ). Poncirin also enhanced expression of the osteogenic marker genes including alkaline phosphatase (ALP) and osteocalcin ...

2011-05-01

Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes "2"0"3Pb and "2"1"2Pb

The half-life of "1"0"9Cd was measured by following the decay of sources from a radiochemically pure solution with two different measuring systems: an ionisation chamber and a high-purity germanium (HPGe) detector. The measurements were performed over a period of 3.6 years, i.e. about 2.8 half-lives of "1"0"9Cd. The resulting half-life values and detailed uncertainty budgets (k=1) are presented for both systems. The result obtained with the ionisation chamber, 462.36 (33) days, and the one obtained with the HPGe detector, 461.92 (76) days, are mutually consistent. The weighted mean of our measured values, T_1_/_2("1"0"9Cd)=462.29 (30) days, is consistent with the currently recommended values of 461.4 (12) days and 462.0 (3) days. From a set of selected experimental values published after 1970, a 'partially weighted mean' of T_1_/_2("1"0"9Cd)=462.36 (39) days was calculated. More measurements are needed ...

2011-05-01

Structural Change Accompanying Crystallization in the Lithium Ion Conductive Li{sub 2}S-SiS{sub 2}-Li{sub 3}PO{sub 4} Oxysulfide Glasses

Radioisotopes of Pb(II) have been of some interest in radioimmunotherapy and radioimmunoimaging (RII). However, the absence of a kinetically stable bifunctional chelating agent for Pb(II) has hampered its use for these applications. "2"0"3Pb (T_1_/_2=52.02 h) has application potential in RII, with a #gamma#-emission that is ideal for single photon emission computerized tomography, whereas "2"1"2Pb (T_1_/_2=10 h) is a source of highly cytotoxic #alpha#-particles via its decay to its "2"1"2Bi (T_1_/_2=60 min) daughter. The synthesis of the novel bifunctional chelating agent 2-(4-isothiocyanotobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoyl methyl)-cyclododecane (4-NCS-Bz-TCMC) is reported herein. The Pb[TCMC]"2"+ complex was less labile to metal ion release than Pb[DOTA]"2"- at pH 3.5 and below in isotopic exchange experiments. In addition to increased ...

2000-01-01

Structural Change Accompanying Crystallization in the Lithium Ion Conductive Li[sub 2]S-SiS[sub 2]-Li[sub 3]PO[sub 4] Oxysulfide Glasses

The structural change of the (100-x)(0.6Li{sub 2}S{center_dot}0.4SiS{sub 2})centre dotxLi{sub 3}PO{sub 4} oxysulfide glassesduring crystallization was analyzed by means of solid-state nuclear magnetic resonance (NMR) and X-ray photoelectron spectroscopy (XPS). The unique tetrahedral units of SiO{sub n}S{sub 4-n} (n=1,2,3) and PO{sub n}S{sub 4-n} (n=1,2,3) present in the glass samples vanished and the SiS{sub 4}, PS{sub 4}, SiO{sub 4} units increased with proceeding of the crystallization process. Nonbridging sulfur and oxygen atoms decreased while bridging oxygens and S{sup 2-} increased with proceeding of the crystallization process. Large structural difference between the glass and the corresponding crystallized sample explained the high stability against crystallization found in the oxysulfide glass with the composition of X=5. (author)

1999-02-01

Roper resonance and S_1_1(1535) from lattice QCD

The structural change of the (100-x)(0.6Li[sub 2]S[center dot]0.4SiS[sub 2])centre dotxLi[sub 3]PO[sub 4] oxysulfide glassesduring crystallization was analyzed by means of solid-state nuclear magnetic resonance (NMR) and X-ray photoelectron spectroscopy (XPS). The unique tetrahedral units of SiO[sub n]S[sub 4-n] (n=1,2,3) and PO[sub n]S[sub 4-n] (n=1,2,3) present in the glass samples vanished and the SiS[sub 4], PS[sub 4], SiO[sub 4] units increased with proceeding of the crystallization process. Nonbridging sulfur and oxygen atoms decreased while bridging oxygens and S[sup 2-] increased with proceeding of the crystallization process. Large structural difference between the glass and the corresponding crystallized sample explained the high stability against crystallization found in the oxysulfide glass with the composition of X=5. (author)

1999-02-01

Roper resonance and S11(1535) from lattice QCD

Using the constrained-curve fitting method and overlap fermions with the lowest pion mass at 180 MeV, we observe that the masses of the first positive and negative parity excited states of the nucleon tend to cross over as the quark masses are taken to the chiral limit. Both results at the physical pion mass agree with the experimental values of the Roper resonance (N"1"/"2"+(1440)) and S_1_1 (N"1"/"2"-(1535)). This is seen for the first time in a lattice QCD calculation. These results are obtained on a quenched Iwasaki 16"3x28 lattice with a=0.2 fm. We also extract the ghost #eta#"'N states (a quenched artifact) which are shown to decouple from the nucleon interpolation field above m_#pi##approx#300 MeV. From the quark mass dependence of these states in the chiral region, we conclude that spontaneously broken chiral symmetry dictates the dynamics of light quarks in the nucleon.

2005-01-06

Excitation of Plasma Fluctuations near ion Giro frequencies during RF Plasma Heating in URAGAN-3M Torsatron

Using the constrained curve fitting method and overlap fermions with the lowest pion mass at 180 MeV, we observe that the masses of the first positive and negative parity excited states of the nucleon tend to cross over as the quark masses are taken to the chiral limit. Both results at the physical pion mass agree with the experimental values of the Roper resonance (N"1"/"2"+ (1440)) and S_1_1 (N"1"/"2"-(1535)). This is seen for the first time in a lattice QCD calculation. These results are obtained on a quenched Iwasaki 16"3 x 28 lattice with a = 0.2 fm. We also extract the ghost #eta#(prime) N states (a quenched artifact) which are shown to decouple from the nucleon interpolation field above m_#pi# #approx# 300 MeV. From the quark mass dependence of these states in the chiral region, we conclude that spontaneously broken chiral symmetry dictates the dynamics of light quarks in the nucleon.

Studies on the separation of Ag(I) during the recovery of Pu by ammonium plutonium(III) oxalate precipitation methodology

Currentless plasma in Uragan-3M (U-3M) is produced and heated by absorption of RF power in the region of Alfven waves (AW). The process of plasma heating was explained in (2) as a result of Cherenkov absorption of energy of the fast (EM) and slow (kinetic Alfven) waves by electrons and turbulent ion heating due to excitation of short wave ion Bernstein waves (IBW). In this report we present results of studies of plasma density fluctuations showing existence of a narrow bands near the frequencies of ? ? n?ci (n=1,2,3).

2006-01-01

Half Life of "1"0"1Mo and "1"0"1Tc #beta#"--decay

Studies on the separation of Ag(I) during the recovery of Pu from analytical waste generated during potentiometric determination of Pu using AgO as oxidant, by precipitation of Pu as ammonium plutonium (III) oxalate have shown that most of the Ag(I) is separated during the reduction of Pu to Pu(III) state by ascorbic acid. A decontamination factor of 54 was obtained. Additional a decontamination factor of 5.8 was obtained during the precipitation of Pu as ammonium plutonium (III) oxalate. The Ag content was determined by gamma spectrometry, using "1"1"1Ag as a tracer (T_1_/_2 7.45 d, #gamma# 342.1 keV) and HPGe as detector. The studies indicate that Ag is preferentially separated almost quantitatively during the recovery of plutonium, when acidity adjustment is done with NaOH instead of NH_3. (author)

2007-02-14

Copper-64 Radiopharmaceuticals for PET Imaging of Cancer: Advances in Preclinical and Clinical Research

In this work, the half-life of the "1"5"5Sm #beta#"- decay was determined using enriched "1"5"4Sm samples submitted to irradiation in the IEA-R1 reactor of IPEN; the activity of the samples were followed for 4-5 consecutive half lives using a 198 cm"3 HPGe detector. The data was corrected using a non paralizable dead time correction and fitted to an exponential decay function using a non linear fitting procedure developed on the MatLab platform. The resulting value--T_1_/_2 = 22.180(26) min--was compatible to the one found in the literature, with a lower uncertainty.

2010-05-21

British Library Electronic Table of Contents (United Kingdom)

Summation Copper-64 (T1/2?=?12.7 hours; ?+, 0.653?MeV [17.8 %]; ??, 0.579?MeV [38.4 %]) has decay characteristics that allow for positron emission tomography (PET) imaging and targeted radiotherapy of cancer. The well-established coordination chemistry of copper allows for its reaction with a wide variety of chelator systems that can potentially be linked to peptides and other biologically relevant small molecules, antibodies, proteins, and nanoparticles. The 12.7-hours half-life of 64Cu provides the flexibility to image both smaller molecules and larger, slower clearing proteins and nanoparticles. In a practical sense, the radionuclide or the 64Cu-radiopharmaceuticals can be easily shipped for PET imaging studies at sites remote to the production facility. Due to the versatility of 64Cu, ...

2009-01-01

Relationship of DNA repair processes to mutagenesis and carcinogenesis in mammalian cells. Progress report, November 1, 1979-October 31, 1980

Steady state temperature profile in a cylinder heated by microwaves

The objective of this research is to determine the role of DNA repair in mutagenesis and carcinogenesis in mammalian cells. Use of the host-cell reactivation viral suicide enrichment procedure was initiated in the isolation of repair-deficient mutants. Lightly mutagenized BHK cells were infected with irradiated Herpes simplex virus (HSV); several radiation-sensitive strains were isolated among the survivors of the infection. The characterization of these strains is progressing and the enrichments are continuing. That alterations in the frequency of mutation of C3H/10T 1/2 cells, occurring as a result of holding the cells in a confluent state following treatment with ethylmethane sulfonate, parallel the alterations in the frequency of neoplastic transformation was found. The repair capabilities of BHK cells were found to be intermediate in comparison to repair-proficient and -deficient human cells with regard to the reactivation of HSV treated ...

Secondary ions from condensed gas solids by singly and multiply charged ion impacts

A new theory has been developed to calculate the steady state temperature profile in a cylindrical sample positioned along the entire axis of a cylindrical microwave cavity. Temperature profiles were computed for alumina rods of various radii contained in a cavity excited in one of the TM{sub 0n0} modes with n = 1, 2 or 3. Calculations were also performed with a concentric outer cylindrical tube surrounding the rod to investigate hybrid treating. The parametric studies of the total sample center and surface temperatures were performed as a function of the total power transmitted into the cavity. Also, the total hemispherical emissivity was varied at boundaries of the rod, surrounding tube, and cavity walls. The results are discussed in the context of controlling the average rod temperature and the temperature distribution in the rod during microwave processing.

1995-12-31

R-matrices for highest weight representations of s-circumflexl{sub q}(2,C) at roots of unity

Ion desorption from a condensed gas solid Ne impacted by singly- and multiply-charged Ar"q"+ ions (q = 1-7) has been investigated. Various secondary ions such as cluster ions, Ne"+_n (n = 2-20) as well as atomic ions are observed. Mass spectral patterns, thickness dependence of the yields, and kinetic energy distributions of the desorbed Ne"+_n (n = 1,2) depend strongly on the projectile charge state. These results indicate that the dissipation of the projectile potential energy on the surface leads to the desorption of the monomer and small cluster ions by a Coulomb repulsion between adjacent target ions.

2009-11-01

New high-spin isomer and quasiparticle-vibration coupling in "1"8"7Ir

The general formula is obtained for R-matrices of s-circumflexl{sub q}(2,C) for the highest weight representations both for general q and for q being a root of unity by generalizing G. Gomez`s and Sierra`s one for semiperiodic representations of s-circumflexl{sub q}(2,C) at roots of unity. In a case of general q, direct matrix form is obtained for the well known Jimbo`s R-matrix. In a case of q{sup N}=1 for semiperiodic and spin j<(N-1)/2 representations the new R-matrices are obtained which together with Jimbo`s one obey the spectral parameter dependent Yang-Baxter equations. (author) 16 refs.

1992-10-01

Mass Production of 64Cu with 64Ni(p,n)64Cu Nuclear Reaction and Target Material Recycling

The high-spin structure of the Z=77 nucleus "1"8"7Ir has been studied using the fusion-evaporation reaction "1"8"6W("7Li6n) at a beam energy of 59 MeV. The excitation scheme of this nucleus has been extended by more than 110 new states, including extensions of all previously established rotational bands. The band crossing region of the h_9_/_2 negative-parity yrast band has been revised and new intrinsic high-K states have been identified. In particular, a 29/2"- isomeric state [T_1_/_2=1.8(5)#mu#s] at an excitation energy of 2487 keV has been observed for the first time, and on top of it, a rich level scheme reaching up to spin (59/2"-) and excitation energies around 7 MeV has been established.

2010-05-01

1 2 3 4

Autoradiographic and small-animal PET comparisons between 18F-FMISO, 18F-FDG, 18F-FLT and the hypoxic selective 64Cu-ATSM in a rodent model of cancer

64Cu (T1/2=12.7h, ?- decay: 40%, ?+ decay: 19%, E.C. decay: 41%) is one of the most useful radioisotope in the nuclear medicine due to its multiple decay mode and the intermediate half-life. Several nuclear reaction, i.e., 64Ni(p,n)64Cu, 68Zn(p,?n)64Cu and 64Ni(d,2n)64Cu have been investigated for production. The highest could be obtained with proton irradiation on the enriched 64Ni target. For mass and routine production, the 64Ni target fabrication using electroplating, the reliable chemical separation of 64Cu from the irradiated 64Ni target and the effective recovery process for the recycling of very expensive enriched material ($20,000/g) and so forth are absolutely necessary to be established. In this work, we report our mass production method of 64Cu with 64Ni and Cyclone-30 accelerator

2009-05-01

British Library Electronic Table of Contents (United Kingdom)

IntroductionCopper(II)-diacetyl-bis(N4-methylthiosemicarbazone), or Cu-ATSM, a hypoxia imaging agent, has been shown to be predictive of response to traditional cancer therapies in patients with a wide range of tumors. It is known that the environment of the tumor results in a myriad of physiological consequences, including hypoxia, alterations in metabolism and proliferation. In an effort to better characterize the relationships between Cu-ATSM and other prominent radiopharmaceuticals, this current study was undertaken to compare the regional distribution of 64Cu-ATSM with [18F]fluoromisonidazole (18F-FMISO), [18F]fluoro-2-deoxy-d-glucose (18F-FDG) and [18F]fluorothymidine (18F-FLT) in 9L tumors.MethodsTaking advantage of the different half-life of 18F (t1/2=110 min) in comparison to 64Cu...

2008-01-01

Entropy, confinement, and chiral symmetry breaking

Observation of two charged bottomonium-like resonances

This paper studies the way in which confinement leads to chiral symmetry breaking (CSB) through a gap equation. We argue that entropic effects cut off infrared singularities in the standard confining effective propagator $1/p^4$, which should be replaced by $1/(p^2+m^2)^2$ for a finite mass $m\\sim K_F/M(0)$ [$M(0)$ is the zero-momentum value of the running quark mass]. Extension of an old calculation of the author yields a specific estimate for $m$. This cutoff propagator shows semi-quantitatively two critical properties of confinement: 1) a negative contribution to the confining potential coming from entropic forces; 2) an infrared cutoff required by gauge invariance and CSB itself. Entropic effects lead to a proliferation of pion branches and a $\\bar{q}q$ condensate, and contribute a negative term $\\sim -K_F/M(0)$ to the effective pion Hamiltonian allowing ...

2010-01-01

OVERFLOW Convergence Rsults: Baldwin-Barth

We report the observation of two narrow structures at 10610MeV/c^2 and 10650MeV/c^2 in the pi^{\\pm}Upsilon(nS) (n=1,2,3) and pi^{\\pm}h_b(mP) (m=1,2) mass spectra that are produced in association with a single charged pion in Upsilon(5S) decays. The measured masses and widths of the two structures averaged over the five final states are M_1=10608.4\\pm2.0MeV/c^2, Gamma_1=15.6\\pm2.5MeV and M_2=10653.2\\pm1.5MeV/c^2, Gamma_2=14.4\\pm3.2MeV. Analysis favors quantum numbers of I^G(J^P)=1^+(1^+) for both states. The results are obtained with a 121.4fb^{-1} data sample collected with the Belle detector near the Upsilon(5S) resonance, at the KEKB asymmetric-energy e+e- collider.

2011-01-01

Expression Levels of Thymidylate Synthase, Thymidylate Phosphorylase and Dihydropyrimidine Dehydrogenase in Head and Neck Squamous Cell Carcinoma: Preliminary Study

OVERFLOW Convergence Rsults: Baldwin-Barth. M = 0.2, Re = 100 Million. B-B Pre Sca Diss. B-B NoPre Sca Diss. B-B Pre Mat Diss. B-B NoPre Mat Diss. B-B Roe.

UK PubMed Central (United Kingdom)

IntroductionPharyngo-laryngeal tumors classified as T3-4, N0-3, M0, are conventionally treated by mutilating surgery (total (pharyngo)-laryngectomy). Neo-adjuvant chemotherapy with...Full Text Available

Effect of Temperature Variations on Molecular Weight ...

Synthesis and radiolabelling of cysteine derivatives and pharmacological behaviour of their "9"9"mTc complexes

... o3 m~ 0 0 0 .0N I x C ONL LA %D -I Ln C'A %0~~ 7- C4 4'' N I tj . ccnA A . 4- LA (nt 0 0 0 0- LAC o LA o4 - ~ - - - N N 0 t Ln. a o0 %- - -. ...

1972-06-01

High-affinity lead binding proteins in rat kidney cytosol mediate cell-free nuclear translocation of lead

Full text: HMPAO, a butane monoxime derivative of propylene amine and ECD, ethyl cysteinate dimer, are currently being used as brain imaging agents. In an effort to develop new radiopharmaceuticals for imaging brain, we have synthesized amine and imine derivatives of ethyl cysteinate with butane monoxime, optimized labelling procedure with "9"9"mTc and studied the in vivo behaviour of their "9"9"mTc complexes. Imine derivative of ethyl cysteinate with butane monoxime was synthesized by refluxing equimolar amounts of butane monoxime and ethyl cystinate in dry benzene for 3 hours. The product was purified over silica with 10% ethyl acetate in chloroform as eluent. Amine derivative was prepared by reducing the imine derivative with sodium borohydride. The ligands were characterized by NMR spectroscopy and were found to be pure. The ligands were labelled with "9"9"mTc using stannous chloride as reducing agent. The complexes were characterized by paper chromatography, paper electrophoresis ...

1998-09-01

High-affinity lead binding proteins in rat kidney cytosol mediate cell-free nuclear translocation of lead

The PbII binding characteristics of the previously reported PbII binding proteins of rat kidney cytosol were investigated further. Saturation and Scatchard analysis of /sup 203/Pb binding in whole cytosol and in 40% saturated ammonium sulfate precipitated fractions disclosed a class of relatively high-affinity sites with an apparent Kd of approximately 50 nM and binding capacities of approximately 41 and 9 pmol/mg of protein, respectively. Two /sup 203/Pb binding proteins with approximate molecular masses of 63K and 11.5K daltons and a high molecular weight component (greater than 200K) were isolated by Sepharose-6B column chromatography. The time course of association of /sup 203/Pb with cytosol and the 63K protein showed maximum binding at 18 hr which was stable up to 25 hr at 4 degrees C. The approximate half-time dissociation rate (T 1/2) of specifically bound /sup 203/Pb to the 63K protein was 100 min at 4 degrees C whereas the 11.5K ...

1985-02-01

Experimental investigation of the KLL Auger spectrum of "8"8Sr from the EC-decay of "8"8Y

The PbII binding characteristics of the previously reported PbII binding proteins of rat kidney cytosol were investigated further. Saturation and Scatchard analysis of "2"0"3Pb binding in whole cytosol and in 40% saturated ammonium sulfate precipitated fractions disclosed a class of relatively high-affinity sites with an apparent Kd of approximately 50 nM and binding capacities of approximately 41 and 9 pmol/mg of protein, respectively. Two "2"0"3Pb binding proteins with approximate molecular masses of 63K and 11.5K daltons and a high molecular weight component (greater than 200K) were isolated by Sepharose-6B column chromatography. The time course of association of "2"0"3Pb with cytosol and the 63K protein showed maximum binding at 18 hr which was stable up to 25 hr at 4 degrees C. The approximate half-time dissociation rate (T 1/2) of specifically bound "2"0"3Pb to the 63K protein was 100 min at 4 degrees C whereas the 11.5K protein showed ...

Distributions of "1"3"7Cs, "2"0"1T1, "2"0"3Hg, "2"0"3Pb and "5"7Co in a rat hepatoma model. Comparison with "6"7Ga

According to the calculations, intensity of the KL_1L_2("3P_0) Auger transition should drastically increase with increasing atomic number Z due to the relativistic effects. However, this behavior was experimentally proved only for very few elements. A lack of enough precise experimental data in the atomic number region Z<45 does not enable one to distinguish between relativistic and non-relativistic approaches in this region. Thus for Z=38 the KL_1L_2("3P_0/"1P_1) intensity ratio was determined with relative uncertainty of 63 % in the only measurement with external excitation. Here we present results of our investigation of the KLL Auger electron spectrum of "8"8Sr generated in the EC decay of "8"8Y (T_1_/_2= 106.6 d). Electron spectra were measured with the 11 eV instrumental resolution using a combined electrostatic spectrometer. The present value of the KL_2L_3("1D_2) absolute transition energy in Sr is higher by 7.4 eV (i.e. more than ...

2007-06-04

Direct photoaffinity labeling of gizzard myosin with ["3H]uridine diphosphate places Glu185 of the heavy chain at the active site

The distribution of carrier-free "2"0"3Pb-acetate, "2"0"3HgCl_2, "5"7Cocl_2, "1"3"7CsCl and "2"0"1TlCl was investigated in rats bearing thigh-implanted Morris 7777 hepatomas. Viable and nonviable tumor tissue was collected in order to determine the relative affinities of the radiopharmaceutical for these tissues. The animals were sacrificed at 4, 24, 48, 72 and 96 hrs following intravenous injection. Washout of the radioisotope from the viable tumor tissue was rapid, the maximum concentration being reached on or before 4 hrs following injection. In contrast, residual activity within the nonviable tumor tissue decreased much more slowly and in some cases even increased with time. Viable tumor-to-muscle and nonvialbe tumor-to-muscle ratios for "2"0"3Pb, "2"0"3Hg and "5"7Co were comparable to the analogous ratios reported for "6"7Ga. However, none of these isotopes approached "6"7Ga as a potential tumor imaging agent because the large ratios were the result of low muscle uptake rather ...

Dendroaspis natriuretic peptide and the designer natriuretic peptide, CD-NP, are resistant to proteolytic inactivation.

The active site of chicken gizzard myosin was labeled by direct photoaffinity labeling with ["3H]UDP. ["3H] UDP was stably trapped at the active site by addition of vanadate (Vi) and Co"2"+. The extraordinary stability of the myosin.Co2+.[3H]UDP.Vi complex (t1/2 greater than 5 days at 0 degrees C) allowed it to be purified free of extraneous ["3H]UDP before irradiation began. Upon UV irradiation, greater than 60% of the trapped ["3H]UDP was photoincorporated into the active site. Only the 200-kDa heavy chain was labeled, confirming earlier results using ["3H]UTP. Extensive tryptic digestion of photolabeled myosin subfragment 1 followed by high performance liquid chromatography separations and removal of nucleotide phosphates by treatment with alkaline phosphatase allowed two labeled peptides to be isolated. Sequencing of the labeled peptides and radioactive counting showed that Glu185 was the residue labeled. Since UDP is a zero-length ...

A study of palladium silicide formed by focused ion beam implantation of palladium ions

Designer natriuretic peptides (NPs) represent an active area of drug development. In canine and human studies, the designer natriuretic peptide CD-NP demonstrated more desirable therapeutic potential than recombinant B-type NP (BNP), which is known as nesiritide and is approved for treatment of acute decompensated heart failure. However, why CD-NP is more effective than BNP is not known. We previously reported that CD-NP is a poorer activator of human guanylyl cyclase-A (GC-A) and a better activator of human guanylyl cyclase-B than BNP. Here, guanylyl cyclase bioassays were used to compare the susceptibility of CD-NP verses ANP, BNP, CNP and DNP to inactivation by human kidney membranes. The half time (t(1/2)) for CD-NP inactivation was increased by factors of 13, 3 and 4 compared to ANP, BNP and CNP, respectively, when measured in the same assay. Surprisingly, DNP failed to undergo complete inactivation and was the most degradation resistant ...

2011-04-01

The Redshift Evolution of Wet, Dry, and Mixed Galaxy Mergers from Close Galaxy Pairs in the DEEP2 Galaxy Redshift Survey

The formation and properties of Pd_2Si formed by focused ion beam implantation of Pd ions into Si is presented in this thesis. An extensive microstructural study using transmission electron microscopy was undertaken and the as-implanted as well as annealed microstructure is shown. Results of other analysis techniques such as Rutherford back scattering and secondary ion mass spectrometry etc. are also presented. Kinetic information on the growth of Pd_2Si obtained by both microstructural and resistance measurements indicates that the activation energy for growth of the silicide is around 0.36 to 0.39 eV. This can be compared with the normally reported value of 1.5 eV for Pd_2Si formed by annealing thin film Pd on Si. The growth of the silicide was found to follow t"1"/"2 kinetics. Microstructural observation of the as-implanted samples showed extensive in-situ formation of Pd_2Di and also surprisingly few defect structures. A heat transfer model ...

Latest Observational Constraints on Cardassian Models

We study the redshift evolution of galaxy pair fractions and merger rates for different types of galaxies using kinematic pairs selected from the DEEP2 Redshift Survey. Parameterizing the evolution of the pair fraction as (1+z)^{m}, we find that the companion rate increases mildly with redshift with m = 0.41+-0.20 for all galaxies with -21 < M_B^{e} < -19. Blue galaxies show slightly faster evolution in the blue companion rate with m = 1.27+-0.35 while red galaxies have had fewer red companions in the past as evidenced by the negative slope m = -0.92+-0.59. We find that at low redshift the pair fraction within the red sequence exceeds that of the blue cloud, indicating a higher merger probability among red galaxies compared to that among the blue galaxies. With further assumptions on the merger time scale and the fraction of pairs that will merge, the galaxy major merger rates for 0.1 < z ...

2008-01-01

Including the relativistic kinetic energy in a spline-augmented plane-wave band calculation

Constraints on the original Cardassian model and the modified polytropic Cardassian model are examined from the latest derived 397 Type Ia supernova (SNe Ia) data, the size of baryonic acoustic oscillation peak from the Sloan Digital Sky Survey (SDSS), the position of first acoustic peak of the Cosmic Microwave Background radiation (CMB) from the five years Wilkinson Microwave Anisotropy Probe (WMAP), the x-ray gas mass fractions in clusters of galaxies, and the observational H(z) data. In the original Cardassian model with these combined data set, we find $\\Omega_{m0}=0.271^{+0.014}_{-0.014}, n=0.035^{+0.049}_{-0.049}$ at $1 \\sigma$ confidence level. And in the modified polytropic Cardassian model, we find that $\\Omega_{m0}=0.271^{+0.014}_{-0.015}$, $n=-0.091^{+0.331}_{-1.908}$ and $\\beta=0.824^{+0.750}_{-0.622}$ within $1\\sigma$ confidence level. According to these observations, the acceleration ...

2009-01-01

First-principles calculations of the stability and local structure of #alpha#-sialon ceramics on the line Si_3N_4- 1/2 Ca_3N_2:3AlN

The first-order relativistic correction to the kinetic energy of an electron, the mass-velocity term, is not bounded from below. It can, therefore, not be used within a variational framework. To overcome this deficiency we developed a method to include the entire relativistic kinetic energy #sq root#(p"2c"2+m_0"2c"4)-m_0c"2 in a spline-augmented plane-wave band calculation. The first results for silver are quite promising, especially for d and p states: The analysis of the energies of the core states as well as of the valence band structure suggests that the energies of d bands are reproduced within 1 mRy. However, the combination of the relativistic kinetic energy with the Darwin term leads to energies which are too low for s-like valence states by 10 mRy. Therefore, the s and d valence band complex is spread out and the Fermi level is lowered by the same amount as the s states. We expect to overcome ...

Enhancement of the absorption of CO{sub 2} in alkaline buffer solutions: Joint action of two enhancers

The atomic structures of calcium sialons Ca_xSi_1_2_-_mAl_mN_1_6 (m = 0.5, 1, 2, 4) with the #alpha#- or #beta#-Si_3N_4-type structure were calculated, using the ab initio DFT approach, including relaxations of both lattice parameters and positions of the atoms. For all m values the #alpha#-Si_3N_4-type structure has a lower energy than the #beta#-type. For m = 1, 2 and 4 the #alpha#-type structure is also stable against decomposition into the metal nitrides, in agreement with experimental data. For m = 0.5 stability becomes uncertain. Al ions prefer positions close to Ca. Rather strong structural relaxations occur around the Ca ion.

2004-04-28

Changes of the electron density distribution during MHD activity in CHS

The authors measured the absorption of CO{sub 2} in alkaline 0.5 M/0.5 M sodium carbonate/bicarbonate buffers containing either saccharose and sodium arsenite or saccharose and formaldehyde. Absorption enhancement increased upon increasing the concentration of either of the catalysts, but the joint action of the two was always less than the sum of their individual effects, the difference being a function of the acidities and concentrations of the catalysts and the pH of the carbonate/bicarbonate buffer solution

1999-05-01

1 2 3 4

Probing quantum gravity using photons from a flare of the active galactic nucleus Markarian 501 observed by the MAGIC telescope

Density oscillations induced by MHD activities were observed in NBI heated plasmas on CHS by using an HCN laser interferometer. The accompanied changes of the density profiles were also observed. The oscillations are composition of m=0 sawteeth like crash and m=2 sinusoidal oscillations as a post courser of the crash. Possible models of the oscillation structure are examined in order to explain experimental data of the interferometer. Rotating plasma core, which is hollow profile and keeps constant elongation of the flux surface can explain amplitude and phase distribution of the sinusoidal oscillation. (author)

2000-09-01

Z-Observables and the Effective Weak Mixing Angle in the MSSM

We analyze the timing of photons observed by the MAGIC telescope during a flare of the active galactic nucleus Mkn 501 for a possible correlation with energy, as suggested by some models of quantum gravity (QG), which predict a vacuum refractive index {approx_equal}1+(E/M{sub QGn}){sup n}, n=1,2. Parametrizing the delay between {gamma}-rays of different energies as {delta}t={+-}{tau}{sub l}E or {delta}t={+-}{tau}{sub q}E{sup 2}, we find {tau}{sub l}=(0.030{+-}0.012) s/GeV at the 2.5-{sigma} level, and {tau}{sub q}=(3.71{+-}2.57)x10{sup -6} s/GeV{sup 2}, respectively. We use these results to establish lower limits M{sub QG1}>0.21x10{sup 18} GeV and M{sub QG2}>0.26x10{sup 11} GeV at the 95% C.L. Monte Carlo studies confirm the MAGIC sensitivity to propagation effects at these levels. Thermal plasma effects in the source are negligible, but we cannot exclude the importance of some other source effect.

2008-10-16

The Dissipative Merger Progenitors of Elliptical Galaxies

We make a comparison of the predicted effective weak mixing angle, the Z-on resonance asymmetries and the W-boson mass to the LEP and SLD data at their present status. We find that the predicted MSSM values for the effective weak mixing angle are in agreement with the LEP+SLD average value for a ``heavy'' SUSY breaking scale while we observe an agreement with SLD data in the case of a ``light'' SUSY breaking scale. The resulting values for the W-boson mass and for the electron left-right asymmetries are compatible with CDF,UA2,DO and LEP data respectively. Unexpectedly we find that the supersymmetric QCD contributions to the Z-observables tend to vanish everywhere in the M1/2-M0 plane. Furthermore, values of M1/2 which are greater than 500 GeV are favoured by the MSSM if one considers the current experimental value for the strong coupling.

1998-01-01

Squamous cell carcinoma of the oropharynx: Ki-67 and p53 can identify patients at high risk for local recurrence after surgery and postoperative radiotherapy

We address the deviations of the scaling relations of elliptical galaxies from the expectations based on the virial theorem and homology, including the "tilt" of the "fundamental plane" and the steep decline of density with mass. We show that such tilts result from dissipative major mergers once the gas fraction available for dissipation declines with progenitor mass, and derive the scaling properties of the progenitors. We use hydrodynamical simulations to quantify the effects of major mergers with different gas fractions on the structural properties of galaxies. The tilts are driven by the differential shrinkage of the effective stellar radius as a function of dissipation in the merger, while the correlated smaller enhancements in internal velocity and stellar mass keep the slope of the velocity-stellar mass relation near V \\pr M_*^{1/4}. The progenitors match a straightforward model of disc formation in LCDM haloes. Their total to stellar mass ratio within the effective radius ...

2006-01-01

Thermodynamics of complexation of aqueous 18-crown-6 with potassium ion: apparent molar volumes and apparent molar heat capacities of aqueous 18-crown-6 and of the (18-crown-6 + potassium chloride) complex at temperatures (278.15 to 393.15) K, at molalities (0.02 to 0.3) mol . kg"-"1, and at the pressure 0.35 MPa

Purpose: To assess the prognostic value of biologic (p53, Ki-67) and clinical factors in squamous cell carcinoma of the oropharynx after radical surgery and postoperative radiotherapy (RT). Methods and Materials: Between 1985 and 1995, a total of 102 patients with 104 tumor sites were entered onto the study. Fifty-five primary tumors (53%) involved the tonsils, 26 (25%) the soft palate, and 23 (22%) the base of the tongue. Median age was 53 years (range 36-80 years). The clinical T- and N-categories (UICC 1997) were: T1 (30), T2 (47), T3 (22), T4 (5), N0 (33), N1 (28), N2 (42), and N3 (1). Histologically-clear margins were achieved in all patients by initial surgery. Postoperative RT to the primary and regional lymphatics was given, to a total of 60 Gy in 6 weeks, and single daily fractions of 2 Gy. The expression of the nuclear p53- and Ki-67-labeling index (LI) was investigated by immunostaining using the monoclonal antibodies DO-7 and MIB 1. The nuclear p53-intensity (p53-I) was ...

2000-11-01

Solubility limits of #alpha#' SIAION solid solutions in the system Si,Al,Y/N,O

We have measured the densities at temperatures T = (278.15 to 363.15) K and heat capacities at T = (278.15 to 393.15) K of aqueous solutions of 18-crown-6 and of (18-crown-6 + KCl) at molalities m = (0.02 to 0.3) mol . kg"-"1 and at the pressure 0.35 MPa. We have calculated apparent molar volumes V_#phi# and apparent molar heat capacities C_p_,_#phi# for 18-crown-6(aq), and we have applied Young's Rule and have accounted for chemical speciation and relaxation effects to resolve V_#phi# and C_p_,_#phi# for the (18-crown-6: K"+,Cl"-)(aq) complex in the mixture. We have also calculated estimates of the change in volume #DELTA#_rV_m, the change in heat capacity #DELTA#_rC_p_,_m, the change in enthalpy #DELTA#_rH_m, and the equilibrium quotient log Q for formation of the complex at T = (278.15 to 393.15) K and m = (0 to 0.3) mol . kg"-"1.

2004-12-01

Neutrino fluxes from constrained minimal supersymmetric standard model lightest supersymmetric particle annihilations in the Sun

The solubility limit of #alpha#'-SiAlON solid solutions on the Si_3N_4-YN:3AlN composition join in the system Si_3N_4-YN-AlN has been determined at 1800 degrees C. The end members of these solid solutions are Y_0_._4_3Si_1_0_._7Al_1_._3N_1_6 and Y_0_._8Si_9_._6Al_2_._4N_1_6. Unit-cell dimensions of the #alpha#'-SiAlON solid solutions in the system Si,Al,Y/N,O can be expressed as follows: a_0 (Angstrom) = 7.752 + 0.045m + 0.009n, c_0 (Angstrom) = 5.620 + 0.048m + 0.009n, where the #alpha#'-SiAlON solid solution has the formula Y_xSi_1_2_-_(_m _+ _n_)Al_m_+_nN_1_6_-_nO_n. The single-phase boundary of the solid solution #alpha#'-SiAlON on the composition triangle Si_3N_4-YN:3AlN-Al;N:Al_2O_3 is delineated. The present paper also reports the phase relationships involving #alpha#'-SiAlON.

Contribution \\`{a} l'etude des binaires des types F, G, K, M IX. HD 191588, nouvelle binaire spectroscopique \\`{a} raies simples de type RS Cvn, systeme triple

We evaluate the neutrino fluxes to be expected from neutralino lightest supersymmetric particle (LSP) annihilations inside the Sun, within the minimal supersymmetric extension of the standard model with supersymmetry-breaking scalar and gaugino masses constrained to be universal at the grand unified theory scale [the constrained minimal supersymmetric standard model (CMSSM)]. We find that there are large regions of typical CMSSM (m_1_/_2,m_0) planes where the LSP density inside the Sun is not in equilibrium, so that the annihilation rate may be far below the capture rate. We show that neutrino fluxes are dependent on the solar model at the 20% level, and adopt the AGSS09 model of Serenelli et al. for our detailed studies. We find that there are large regions of the CMSSM (m_1_/_2,m_0) planes where the capture rate is not dominated by spin-dependent LSP-proton scattering, e.g., at large m_1_/_2 along the ...

2010-04-15

q-Virasoro algebra, q-conformal dimensions and free q-superstring

An accident of misidentification has brought to light the interesting system HD 191588, a new RS CVn-type spectroscopic binary. A radial-velocity study of the primary star, the only seen component, carried out at the Observatoire de Haute-Provence with the Coravel instrument and subsequently at the Cambridge Observatories with a similar one, reveals two orbital motions: a short-period orbit (60 days) and a long-period one (about 4.5 years), so this star is a triple system. The following orbital elements are obtained: (1) for the long-period orbit P = 1667+/-17 days, T = 50901 +/-67 MJD, Gamma = +2.09 +/-0.07 km/s, K = 2.51 +/-0.13 km/s, e = 0.18 +/-0.04, omega = 228deg +/- 14 deg, a1 sin i = 56.7 +/- 3.0 Gm, f(m) = 0.0026 +/-0.0004 M_sun, and (2) for the short-period orbit P = 60.0269 +/-0.0016 days, T = 50482.6 +/-3.3 MJD, gamma is var., K = 24.03 +/- 0.09 km/s, e = 0.012 +/-0.004, omega = 233 deg +/-19deg, a1 sin i = 19.83 +/-0.07 Gm, ...

2003-01-01

The Effective Theory of Inflation and the Dark Matter Status in the Standard Model of the Universe

The commutators of standard Virasoro generators and fields generate various representations of the centreless Virasoro algebra depending on a conformal dimension J of the field in question (J is related to the Bargmann index of SU(1,1) generated by L_m, m=0,#+-#1). We introduce the notion of q-conformal dimension for various oscillator realizations of q-deformed Virasoro (super)algebras proposed earlier. We use the field theoretical approach introduced recently in which the q-Virasoro currents L"#alpha# (z) are expressed as Schwinger-like point-split normally ordered quadratic expressions in elementary fields. We extend this approach and probe the elementary fields A(z) (the q-superstring coordinate, momentum and fermionic field) and their powers by the q-Virasoro generators L"#alpha#_m (i.e. we calculate the commutators [L"#alpha#_m,A(z)]) and show that to all of them can be assigned just the standard non-deformed conformal dimension. (orig.).

1996-12-01

Proton G{sub E}/G{sub M} from beam-target asymmetry

We present here the effective theory of inflation `a la Ginsburg-Landau in which the inflaton potential is a polynomial. The slow-roll expansion becomes a systematic 1/N expansion where N ~ 60. The spectral index and the ratio of tensor/scalar fluctuations are n_s - 1 = O(1/N), r = O(1/N) while the running turns to be d n_s/d \\ln k = O(1/N^2) and can be neglected. The energy scale of inflation M ~ 0.7 10^{16} GeV is completely determined by the amplitude of the scalar adiabatic fluctuations. A complete analytic study plus the Monte Carlo Markov Chains (MCMC) analysis of the available CMB+LSS data showed: (a) the spontaneous breaking of the phi -> - phi symmetry of the inflaton potential. (b) a lower bound for r: r > 0.023 (95% CL) and r > 0.046 (68% CL). (c) The preferred inflation potential is a double well, even function of the field with a moderate quartic coupling yielding as most probable values: n_s = 0.964, r = 0.051. This ...

2010-01-01

Free electron laser facilities employing a 150-MeV linac injector for Saga synchrotron light source

The ratio of the proton's electric to magnetic form factor, G{sub E}/G{sub M}, can be extracted in elastic electron-proton scattering by measuring cross sections, beam-target asymmetry, or recoil polarization. Separate determinations of G{sub E}/G{sub M} by cross sections and recoil polarization observables disagree for Q{sup 2}>1 (GeV/c){sup 2}. Measurement by a third technique might uncover an unknown systematic error in either of the previous measurements. The beam-target asymmetry has been measured for elastic electron-proton scattering at Q{sup 2} = 1.51 (GeV/c){sup 2} for target spin orientation aligned perpendicular to the beam momentum direction. This is the largest Q{sup 2} at which G{sub E}/G{sub M} has been determined by a beam-target asymmetry experiment. The result, {mu}G{sub E}/G{sub M}=0.884{+-}0.027{+-}0.029, is compared to previous world data.

2006-09-15

Cloning and mapping of the mouse {alpha}7-neuronal nicotinic acetylcholine receptor

Free electron laser (FEL) facilities as the FELI FEL Facility are proposed, for which a 150-MeV linac type injector for a Saga synchrotron light source (SLS) is employed in FEL mode. The linac has two operating modes; short macropulse mode a 1 #mu#s at 150 MeV for injection to a 1 - 1.3-GeV third generation type storage ring and long macropulse mode of 12 #mu#s at 100 MeV for four FEL Facilities. The macropulse beam consists of a train of several ps, 0.6 nC microbunches (peak current 100 A) repeating at 89.25 MHz. We are aiming to supply high power level photon beams covering an attractive wavelength range from 0.05 nm (25 keV) to 200 #mu#m (0.006 eV) for scientific researches, bio-medical and industrial applications, using the Saga third generation type SLS with a superconducting wiggler and the proposed four FEL Facilities. (author)

1999-12-01

Bar mode instability in relativistic rotating stars a post Newtonian treatment

We report the isolation of cDNA clones for the mouse {alpha}7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind a-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse {alpha}7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The {alpha}7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 {+-}1.7 cM-Gas2-0.9 cM {+-} 0.9 cM-D7Mit70-1.8 {+-} 1.2 cM- Acra7-4.4 {+-}1.0 cM-Hras1-ps11/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14. 26 refs., 3 figs.

1995-03-20

Apparent molar volumes and apparent molar heat capacities of aqueous nickel(II) nitrate, copper(II) nitrate, and zinc(II) nitrate at temperatures from (278.15 to 393.15) K at the pressure 0.35 MPa

We construct analytic models of incompressible, rigidly rotating stars in PN gravity and study their stability against nonaxisymmetric Jacobi-like bar modes. PN configurations are modeled by homogeneous triaxial ellipsoids and the metric is obtained as a solution of Einstein's equations in 3+1 ADM form. We use an approximate subset of the equations well-suited to numerical integration for strong field, 3D configurations in quasi--equilibrium. These equations are exact at PN order, and admit an analytic solution for homogeneous ellipsoids. In this paper we present this solution, as well as analytic functionals for the conserved global quantities, M, M_0 and J. By using a variational principle we construct sequences of axisymmetric equilibria of constant density and rest mass, i.e. the PN generalization of Maclaurin spheroids, which are compared to other PN and full relativistic sequences presented by previous authors. We then consider ...

1997-01-01

Adiabatic interpretation of particle creation in a de Sitter universe

Apparent molar volumes V{sub phi} and apparent molar heat capacities C{sub p,phi} were determined for aqueous solutions of nickel(II) nitrate, copper(II) nitrate, and zinc(II) nitrate at molalities m=(0.01 to 0.5) mol {center_dot} kg{sup -1}, and at the pressure p=0.35 MPa. Solution densities obtained using a vibrating-tube densimeter at T=(278.15 to 368.15) K were used to calculate V{sub phi} values. Heat capacity measurements obtained with a twin fixed-cell, differential-output, power-compensating, temperature-scanning calorimeter at T=(278.15 to 393.15) K were used to calculate values of C{sub p,phi}. Our results were then fitted to functions of m and T and compared to literature values.

2004-05-01

( sup 14 C)-Sucrose uptake by guard cell protoplasts of pisum sativum, argenteum mutant

The choice of vacuum state for a quantum scalar field propagating in a de Sitter spacetime (massive and arbitrarily coupled to the gravitational field) is discussed. The problem of finite-time initial conditions for the mode functions is analyzed, as well as how these determine the vacuum state of the quantum system. The principle guiding the choice of vacuum state is the following: one wants the vacuum contribution to the energy-momentum tensor to contain all the ultraviolet divergent terms, so that the particle creation terms are finite, and covariantly conserved. There is a suitable set of modes (instantaneous adiabatic basis) in which this splitting of the expectation value of the energy-momentum tensor can be carried out. Numerical results are presented for different finite-time initial conditions (m = 0.6, {zeta} = 1/6). The nature of the particle creation effect is described and its relationship to the concept of a horizon crossing time ...

1998-06-10

Void fraction measurements using neutron radiography

Guard cells rely on import for their supply with reduced carbon. The authors tested by silicone oil centrifugation the ability of guard cell protoplasts to accumulated ({sup 14}C)-sucrose. Uptake rates were corrected after measurement of {sup 14}C-sorbitol and {sup 3}H{sub 2}O spaces. Sucrose uptake followed biphasic kinetics, with a high-affinity component below 1 mM external sucrose (apparent K{sub m} 0.8 mM at 25C) and a low-affinity nonsaturable component above. Uptake depended on pH (optimum at pH 5.0). Variations in the concentrations of external KCl, CCCP, and valinomycin indicated that about one-half of the sucrose uptake rate could be related to an electrochemical gradient across the plasmalemma. Total uptake rates measured at 5 mM external sucrose seem to be sufficient to replenish emptied plastids with starch within a few hours.

1991-05-01

Pulmonary retention of lead: an experimental study in man

Real-time neutron radiography is being evaluated for studying the dynamic behavior of two phase flow and for measuring void fraction in vertical and inclined water ducts. This technique provides a unique means of visualizing the behavior of fluid flow inside thick metal enclosures. To simulate vapor conditions encountered in a fluid flow duct, an air-water flow system was constructed. Air was injected into the bottom of the duct at flow rates up to 0.47 I/s (1 cfm). The water flow rate was varied between 0--3.78 I/m (0--1 gpm). The experiments were performed at the Pennsylvania State University nuclear reactor facility using a real-time neutron radiography camera. With a thermal neutron flux on the order of 10{sup 6}n/cm{sup 2}/s directed through the thin duct dimension, the dynamic behavior of the air bubbles was clearly visible through 5 cm (2 in.) thick aluminum support plates placed on both sides of the duct wall. Image analysis techniques ...

1992-12-31

Copper removal by algal biomass: Biosorbents characterization and equilibrium modelling

This human investigation of lead absorption from the lungs utilized two forms of lead, lead chloride and lead hydroxide; the former was used in picogram amounts and the latter at microgram levels. These two species of lead were selected in an attempt to simulate the range of physicochemical properties found in atmospheric lead (urban air). Aerosols labeled with lead-203 were made of comparable aerodynamic size (MMAD 0.25 ..mu..m +- 0.1) by using sodium chloride as the deposition-determining aerosol. After brief, mouthpiece exposures, 17 subjects were followed by serial counting with a thoracic array of 12 2-in. scintillation detectors and two 2-in. leg counters, all coupled to single channel analyzers. Serial blood samples were also taken. The two exposure groups showed similar total deposition values (23 vs 26%) and the same biological retention halftimes, viz., 22.6 h. When the retention data were corrected for blood-borne /sup 203/Pb, the ...

1980-04-01

1 2 3 4

The general principles of Cu(II) binding to algal waste from agar extraction, composite material and algae Gelidium, and different modelling approaches, are discussed. FTIR analyses provided a detailed description of the possible binding groups present in the biosorbents, as carboxylic groups (D-glucuronic and pyruvic acids), hydroxyl groups (cellulose, agar and floridean starch) and sulfonate groups (sulphated galactans). Potentiometric acid-base titrations showed a heterogeneous distribution of two major binding groups, carboxyl and hydroxyl, following the quasi-Gaussian affinity constant distribution suggested by Sips, which permitted to estimate the maximum amount of acid functional groups (0.36, 0.25 and 0.1 mmol g{sup -1}) and proton binding parameters (pK{sup '}{sub H}=5.0,5.3and4.4;m{sub H} = 0.43, 0.37, 0.33), respectively for algae Gelidium, algal waste and composite material. A non-ideal, semi-empirical, thermodynamically consistent (NICCA) isotherm fitted better ...

2009-04-30

Thermodynamic investigation of crystalline K{sub 2}Cr{sub 2}O{sub 7} and aqueous K{sub 2}Cr{sub 2}O{sub 7} solution

Purpose. To report a comparative prospective long-term functional analysis after Riboflavin UV A corneal cross-linking (CXL) in three different age groups of patients affected by progressive keratoconus (KC). Methods. Functional analysis comprised paediatric patients (?18 years) included 152 eyes (29.5%); intermediate group (19-26 years) 286 eyes (55.4%), and adults (?27 years) 78 eyes (15.1%). CXL was performed according to the Siena protocol by using the Vega CBM (Caporossi-Baiocchi-Mazzotta) X linker (CSO, Florence, Italy) at Siena University by the same authors. Pre- and post-op examinations included UCVA, BSCVA, corneal topography, and surface aberrometry (CSO Eye Top, Florence, Italy), at 48 months followup. Results. At 48 months followup paediatrics, intermediate, and adult patients showed a mean gain in UCVA of +0.2, +0.14 and +0.12 Snellen lines. BSCVA gained by a mean of +0.21, +0.2, and +0.1 Snellen lines. K(max) was reduced by a mean value of -0.9?D, -0.6?D, and -0.5?D, ...

2011-08-04

Characterization of [[sup 123]I]IDAM as a novel single-photon emission tomography tracer for serotonin transporters

The molar heat capacities (C{sub p,m}) of crystalline potassium dichromate (K{sub 2}Cr{sub 2}O{sub 7} (cr)) and aqueous K{sub 2}Cr{sub 2}O{sub 7} solution (0.1699 mol.kg{sup -1}) were measured in the temperature range from 100 to 390 K and from 80 to 370 K by an automatic adiabatic calorimeter equipped with a small cell of internal volume of 6 cm{sup 3}, respectively. No phase transition took place in the temperature range from 100 to 390 K for K{sub 2}Cr{sub 2}O{sub 7} (cr). The relationships of C{sub p,m} of K{sub 2}Cr{sub 2}O{sub 7} (cr) with respect to T were established to be C{sub p,m} 177.53 + 161.92 X - 138.14 X{sup 2} - 209.67 X{sup 3} + 160.35 X{sup 4} + 137.44 X{sup 5} - 41.291 X{sup 6} and C{sub p,m} 177.52 + 171.66 X -149.59 X{sup 2} - 246.17 X{sup 3} + 194.79 X{sup 4} + 167.30 X{sup 5} - 64.368 X{sup 6} (X=(T-245.00)/145.00) for Series 1 and Series 2 experiments, respectively. No phase transition took place for the solution from 80 to 270 K. The function of C{sub p,m} of ...

2003-07-01