UK PubMed Central (United Kingdom)

PURPOSE: To determine the frequency of ophthalmic abnormalities in patients with cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome) and T-cell lymphoma involving the skin and...Full Text Available

UK PubMed Central (United Kingdom)

Although human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL), the role of viral gene expression in the progression to and maintenance of the...Full Text Available

UK PubMed Central (United Kingdom)

The most common cutaneous T-cell lymphomas (CTCLs) – mycosis fungoides (MF) and Sézary Syndrome – are characterised by the presence of clonally expanded, skin-homing helper-memory...Full Text Available

UK PubMed Central (United Kingdom)

Cutaneous T-cell lymphoma is typically a clonal neoplasm of epidermotropic CD4+ T-lymphocytes that includes the entity mycosis fungoides (MF). After identification of patients with recurrent MF treated...Full Text Available

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Abstract Herpesvirus saimiri (HVS) causes acute lymphoma and leukemia upon experimental infection of various monkey species. HVS strain C488 is also capable of transforming human T-lymphocytes to stable growth in culture. The most susceptible species for oncogenesis are New World primates, in particular the cottontop tamarin (Saguinus oedipus). However, Old World monkeys such as macaques are the most used animal model for the close-to-human situation. The limited data on HVS infection in Old World monkeys prompted us to investigate susceptibility to infection and disease induction by HVS in macaques. After having established that rhesus macaques can be infected productively, and that rhesus T-cells can be transformed in vivo by HVS, we observed induction of lymphoma in all inoculated anima...

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Sixteen patients with advanced cutaneous T-cell lymphoma (CTCL) with or without lymph node involvement, but without evidence of extranodal manifestations, were treated with a combination of total skin electron beam therapy (TSEB) and total nodal irradiation (TNI). Fourteen (87%) patients achieved a complete response (CR) lasting from 1 to 84+ months (median, 8+ months) from the completion of treatment. The best results occurred in 6 patients with pretumorous intracutaneous CTCL (Stages IB and IIA) where the CR has lasted in all patients from 8 to 84+ months (median about 27+ months). Radiotherapy was well tolerated with the major toxicity being bone marrow suppression. The authors conclude that combined TSEB and TNI is a relatively safe and effective treatment for patients with CTCL prior to the development of lymph node involvement. Long-term follow-up is needed to assess the curative potential of this treatment.

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B-cell Chronic Lymphocytic Leukemia; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

International Nuclear Information System (INIS)

Electron beam therapy of lesions such as cutaneous metastatic carcinoma and reticulum cell sarcoma is performed via multiple portals for a wide irradiation field. However, the dose distribution in border areas is generally uneven, resulting in hot and cold dose areas depending on the intervals of the portals. We performed electron irradiation by the pendulum technique, especially on curved areas, and evaluated the technique in various respects. Pendulum electron beam irradiation is indicated when the length of the cone must be reduced in order to deliver the target volume near the skin surface as well as to avoid the occurrence of hot spots deep in the body. We prepared a 15cm rotating cone by cutting a 30cm fixed irradiation cone. The modification posed no disadvantages in terms of extent and flatness of the beam, or stability during rotation. After determining the relationship between the rotation speed and the dose, the technique was successfully applied to a patient with adult ...

International Nuclear Information System (INIS)

Purpose: Patients with mycosis fungoides [cutaneous T-cell lymphoma (CTCL)] may benefit from adjuvant therapy after completing total skin electron beam therapy (TSEBT). We report the results for (T1(T2)) CTCL patients treated with adjuvant oral psoralen plus ultraviolet light (PUVA) with respect to overall survival (OS), disease-free survival (DFS), salvage of recurrence, and toxicity. Methods and Materials: Between 1974 and 1993, TSEBT was administered to a total of 213 patients with CTCL. Records were reviewed retrospectively, and a total of 114 patients were identified as having T1 or T2 disease. Radiotherapy was provided via a 6-MeV linac to a total of 36 Gy, 1 Gy/day, 4 days/week, for 9 weeks. Beginning in 1988, patients were offered adjuvant PUVA within 2 months of completing TSEBT. This was started at 0.5-2 J/m"2, 1-2 treatments/week, with a taper over 3-6 months. Therapy then continued once per month. There were 39 T1 and 75 T2 ...

DEFF Research Database (Denmark)

Udgivelsesdato: 1988-Jul

UK PubMed Central (United Kingdom)

Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is an aggressive non-Hodgkin lymphoma of T/null immunophenotype that is most prevalent in children and young adults. The...Full Text Available

UK PubMed Central (United Kingdom)

The presence of a high number of activated T cells in the bloodstream and spontaneous proliferation of peripheral blood mononuclear cells in vitro are striking characteristics of human T-cell leukemia...Full Text Available

International Nuclear Information System (INIS)

Non-Hodgkin lymphoma is a common feature of AIDS. Approximately 30-40% of these tumors exhibit clinical features suggestive of endemic Burkitt lymphoma: they are aggressive malignancies that occur in association with Epstein-Barr virus infection, they arise in the setting of immunosuppression, and they carry t(8;14) translocations without detectable rearrangement of the MYC oncogene. To understand the molecular basis of these parallels, the authors analyzed a case of Epstein-Barr-positive AIDS-associated undifferentiated lymphoma. Southern blots show that the tumor exhibits immunoglobulin joining segment rearrangement but no rearrangement of the MYC oncogene. Cloning of the rearranged joining segment allowed the isolation of recombinant clones encompassing the translocation breakpoint, and sequencing of the translocation junction disclosed that the breakpoint is situated 7 base pairs from the chromosome 14 site involved in ...

UK PubMed Central (United Kingdom)

The AKR mouse strain is characterized by a high incidence of spontaneous thymic lymphoma that appears in older animals (greater than 6 months of age) and is associated with novel provirus integrations...Full Text Available

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BACKGROUND: Immune suppressant medications such as thiopurines and anti-tumor necrosis factor agents are important for maintaining disease control in most patients with inflammatory bowel diseases (IBDs); however, their use has been associated with the development of malignant lymphoma. The purpose of this Dutch nationwide study was to estimate the relative risk of malignant lymphoma in IBD patients. METHODS: IBD patients who developed a lymphoma between 1997 and 2004 were identified using the Dutch National Database of PALGA. Data from confirmed cases were collected from individual hospitals, including data on Epstein-Barr virus (EBV). The age-adjusted 8-year incidence of malignant lymphoma in the Netherlands was retrieved from the Central Bureau of Statistics. RESULTS: Forty-two hospitals were visited and 285 matches evaluated in the total cohort of 17,834 IBD patients. Forty-four ...

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Purpose: This study presents a dosimetric optimization effort aiming to compare intensity-modulated (IM) X-rays and IM protons in 4 different orbital and paraorbital tumors. These are most challenging targets for standard radiotherapy due to their close relationship with the eyes and related structures. Methods and Materials: A primary orbital lymphoma, an optic nerve meningioma, a sphenoidal ridge meningioma protruding into the orbit, and a pediatric parameningeal paraorbital rhabdomyosarcoma were selected for the purpose of this study. Planning target volumes (PTVs) and organs at risk (OAR) were defined in each patient CT data set for each tumor site. IM X-ray and IM proton three-dimensional treatment plans were implemented. The following total tumor doses were prescribed: 30 Gy for the orbital lymphoma, 54 Gy for both meningiomas, and 50.4 Gy for the rhabdomyosarcoma case. Dose-volume histograms (DVHs) were obtained for ...

UK PubMed Central (United Kingdom)

We have previously described an allelic polymorphism in the V beta 6.1 T-cell receptor gene. The V beta 6.1B allele is associated with disease in a subgroup of patients with juvenile rheumatoid arthritis....Full Text Available

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Primary B-cell lymphoma of thymus is uncommon. We describe the case of a 23-year-old woman with a history of shortness of breath and distended neck veins of 1-month duration. A chest roentgenogram and computed tomographic chest scan of the showed a large anterior mediastinal mass. Tru-cut biopsy revealed primary B-cell lymphoma of thymus. She underwent chemotherapy with no symptomatic improvement. Post-chemotherapy computed tomographic scan of the chest showed no appreciable reduction in tumor size. Surgical excision was carried out with excellent results.

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Abstract Epstein-Barr virus (EBV), which infects not only B cells, but also T cells and natural killer (NK) cells, is associated with multiple lymphoid malignancies. Recently, the proteasome inhibitor bortezomib was reported to induce apoptosis of EBV-transformed B cells. We evaluated the killing effect of this proteasome inhibitor on EBV-associated T lymphoma cells and NK lymphoma cells. First, we found that bortezomib treatment decreased the viability of multiple T and NK cell lines. No significant difference was observed between EBV-positive and EBV-negative cell lines. The decreased viability in response to bortezomib treatment was abrogated by a pan-caspase inhibitor. The induction of apoptosis was confirmed by flow cytometric assessment of annexin V staining. Additionally, cleavage o...

International Nuclear Information System (INIS)

Central Nervous System (CNS) involvement, whether primary by the Human Immunodeficiency Virus - HIV - itself, or secondary (toxoplasmosis or lymphoma) is remarkably frequent in AIDS, in 40 to 70% of cases, depending upon the author. In order to study the natural history of this illness, a cohort of 25 asymptomatic seropositive patients have been established. Every 6 months these patients undergo biological and clinical examinations, as well as Magnetic Resonance brain scans. After two examinations at a 6 month's interval, the first results are reported. Out of these 25 cases, 9 present anomalies: One patient with diffuse cerebral atrophy and 8 others with high signal intensity areas on T2 weighted sequences, like those of the Multiple Sclerosis. No relationship could be demonstrated between the existence of these lesions and various criteria such as age, sex, risk factors and T4 cells count. The nature of these lesions is not lear. They ...

International Nuclear Information System (INIS)

The authors describe the application of an approximate fuzzy C-means (AFCM) clustering algorithm as a data dimension reduction approach to medical magnetic resonance images (MRI). Image data consisted of one T1-weighted, two T2-weighted, and one T2*-weighted (magnetic susceptibility) image for each cranial study and a matrix of 10 images generated from 10 combinations of TE and TR for each body lymphoma study. All images were obtained with a 1.5 Tesla imaging system (GE Signa). Analyses were performed on over 100 MR image sets with a variety of pathologies. The cluster analysis was operated in an unsupervised mode and computational overhead was minimized by utilizing a table look-up approach without adversely affecting accuracy. Image data were first segmented into 2 coarse clusters, each of which was then subdivided into 16 fine clusters. The final tissue classifications were presented as color-coded anatomically-mapped images and as two and ...

British Library Electronic Table of Contents (United Kingdom)

Much progress has been made in the clinical, biological and technical aspects of the T-cell-depleted haploidentical hematopoietic stem cell transplantation (HSCT). Our experience demonstrates that infusing a megadose of extensively T-cell-depleted hematopoietic peripheral blood stem cells after an immuno-myeloablative conditioning regimen in acute leukemia patients ensures sustained engraftment with minimal GvHD without the need of any post-transplant immunosuppressive treatment. Since our first successful pilot study, our efforts have concentrated on developing new conditioning regimens, optimizing the graft processing and improving the post-transplant immunological recovery. The results we have so far achieved in high risk acute leukemia patients show that haploidentical transplantation ...

UK PubMed Central (United Kingdom)

BackgroundThe thymus plays a critical role in the development and maturation of T-cells. Humans have a single thoracic thymus and presence of a second thymus is considered an anomaly....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundSensitization to house dust mite allergens is strongly correlated with asthma. Der p 7 elicits strong IgE antibody and T-cell responses in mite allergic...Full Text Available

UK PubMed Central (United Kingdom)

Evaluation of the protective efficacy of recombinant T-cell-reactive proteins of Coccidioides posadasii in a murine model of coccidioidomycosis has led to the discovery of potential...Full Text Available

UK PubMed Central (United Kingdom)

Tick-borne encephalitis (TBE) virus causes severe encephalitis with serious sequelae in humans. The disease is characterized by fever and debilitating encephalitis that can progress to chronic illness...Full Text Available

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CT findings were compared retrospectively between 9 cases with malignant lymphoma of the anterior mediastinum and 8 cases with invasive thymoma. CT findings of malignant lymphoma were as follows: (1) The majority of the tumors were bilateral and extended beyond the anterior mediastinum to the other mediastinum compartments. (2) Their margin was either smooth or lobulated. (3) Their density was either homogeneous or heterogeneous. In the case with heterogeneous density, ring, triangle and/or band-like low density areas, just like interspace of fused lymph nodes, were demonstrated. Calcification or cysts could not be shown. (4) Patent inherent vessels without deviation were occasionally demonstrated running through the tumors. (5) The tumors faced and contacted widely to anterior chest wall and often pressed the lung laterally at the anterior parietomediastinal pleural reflection. (6) Pleural implants were not demonstrated. (author).

UK PubMed Central (United Kingdom)

Mouse models have dramatically improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundCyclooxygenase (cox) is the rate-limiting enzyme, which catalyzes the conversion of arachidonic acid into prostaglandins and contributes to the inflammatory process. Cyclooxygenase-2...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVE--To determine whether the seeming excess of childhood leukaemia and lymphoma identified in Seascale, Cumbria, UK, remains unusual when put into a wider context. DESIGN--Analysis of cancer...Full Text Available

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Assessment of the immune system's capability to respond to antigens with the generation of specific antibodies, whilst under the influence of a test article, is required in toxicity tests according to the European guideline for repeated dose toxicity testing of medicinal products. The purpose of this study in rats was to validate methodology for the determination of Keyhole Limpet Haemocyanin (KLH)-specific antibodies under the influence of an immunologically active compound. The immunosuppressant FK506, commercially available as Prograf, was administered orally (gavage) to five rats per sex per group at dosages of 0.5mg/kg per day or 3mg/kg per day, for a period of 4 weeks. On days 14 and 22, KLH was administered subcutaneously, with an adjuvant (AluGel), to the two treated groups and a control (i.e. without FK506 treatment) approximately 1h following administration of FK506. Terminal investigations included haematology parameters, titration of KLH-specific antibodies in serum ...

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Autoreactive cytotoxic CD8 T-cells (CTLs) play a key pathogenic role in the destruction of insulin-producing beta-cells resulting in type 1 diabetes. However, knowledge regarding their targets is limited, restricting the ability to monitor the course of the disease and immune interventions. In a multi-step discovery process to identify novel CTL epitopes in human preproinsulin (PPI), PPI was digested with purified human proteasomes, and resulting COOH-fragments aligned with algorithm-predicted HLA-binding peptides to yield nine potential HLA-A1, -A2, -A3 or -B7-restricted candidates. An UV-exchange method allowed the generation of a repertoire of multimers including low-affinity HLA-binding peptides. These were labeled with quantum dot-fluorochromes and encoded in a combinatorial fashion, allowing parallel and sensitive detection of specific, low-avidity T-cells. Significantly increased frequencies of T-cells against four ...

British Library Electronic Table of Contents (United Kingdom)

The most advanced frontier of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is represented by the use of an HLA-partially matched relative as donor. In this type of transplantation, donor-derived natural killer (NK) cells, which are alloreactive towardtoward recipient cells, significantly contribute to the eradication of leukemia blasts. Alloreactive NK cells may also kill host dendritic cells and T lymphocytes, thus preventing graft-versus-host disease and graft rejection, respectively. Sophisticated strategies of adoptive infusion of T-cell lines/clones specific for the most life-threatening pathogens (namely cytomegalovirus, Epstein-Barr virus, Aspergillus and Adenovirus) have been envisaged, and successfully tested in a few pilot trials, to protect the recipient in the...

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We present a sample preparation method for measuring magnesium in individual whole lymphocytes by electron probe X-ray microanalysis. We use Burkitt's lymphoma cells in culture as the test sample and compare X-ray microanalysis of individual cells with atomic absorption analysis of pooled cell populations. We determine the magnesium peak-to-local continuum X-ray intensity ratio by electron probe X-ray microanalysis and calculate a mean cell magnesium concentration of 39 +/- 19 mmol/kg dry weight from analysis of 100 cells. We determine a mean cell magnesium concentration of 34 +/- 4 mmol/kg dry weight by atomic absorption analysis of pooled cells in three cell cultures. The mean cell magnesium concentrations determined by the two methods are not significantly different. We find a 10% coefficient of variation for both methods of analysis and a 30% coefficient of variation in magnesium concentration among individual cells by electron probe X-ray ...

UK PubMed Central (United Kingdom)

The effect of abatacept, a selective T-cell co-stimulation modulator, on vaccination has not been previously investigated. In this open-label, single-dose, randomized, parallel-group, controlled study,...Full Text Available

UK PubMed Central (United Kingdom)

TH1 cytokine secretion was examined in response to synthetic peptides of the 85A component of the major secreted, fibronectin-binding antigen 85 complex from Mycobacterium tuberculosis in seven different...Full Text Available

UK PubMed Central (United Kingdom)

Among important candidates for babesial vaccines are apical complex proteins, including rhoptry-associated protein 1 (RAP-1) from Babesia bovis and B. bigemina, which...Full Text Available

UK PubMed Central (United Kingdom)

A recent clinical trial of a T-cell-based AIDS vaccine delivered with recombinant adenovirus type 5 (rAd5) vectors showed no efficacy in lowering viral load and was associated with increased risk of...Full Text Available

International Nuclear Information System (INIS)

Purpose: Patients with ataxia-telangiectasia (A-T) show greatly increased radiation sensitivity and cancer predisposition. Family studies imply that the otherwise clinically silent heterozygotes of this autosomal recessive disease run a 3.5 to 3.8 higher risk of developing cancer. In vitro studies suggest moderately increased cellular radiation sensitivity of A-T carriers. They may also show elevated clinical radiosensitivity. We retrospectively examined patients who presented with severe adverse reactions during or after standard radiation treatment for mutations in the gene responsible for A-T, ATM, considering a potential means of future identification of radiosensitive individuals prospectively to adjust dosage schedules. Material and Methods: We selected 20 cancer patients (breast, 11; rectum, 2; ENT, 2; bladder, 1; prostate, 1; anus, 1; astrocytoma, 1; Hodgkins lymphoma, 1) with Grade 3 to 4 (RTOG) acute and/or late tissue radiation side ...

UK PubMed Central (United Kingdom)

Despite intensive efforts, the intracellular signaling pathways that mediate apoptosis remain unclear. The human B lymphoma cell line, B104, possesses characteristics that make it an attractive model...Full Text Available

UK PubMed Central (United Kingdom)

Human T cell leukemia/lymphoma virus Type 1 and 2 (HTLV-1 and HTLV-2), together with their simian counterparts (STLV-1, STLV-2), belong to the Primate T lymphotropic viruses group (PTLV). The high percentage...Full Text Available

International Nuclear Information System (INIS)

Expression of Bacterial luciferase enzyme (lux) in mammalian cells would be a powerful bioreporter protein system for in vivo imaging because eukaryotic luciferases need expensive substrates. However, only a few efforts have been made to express bacterial luciferase enzyme in mammalian cells. As the result of this, we attempted to construct bicistronic vector including two bacterial luciferase genes (LuxA and LuxB) for assessing the potential to be visualized in vitro or in vivo by optical imaging system after transfection to mammalian cells. We designed and synthesized luxA and luxB genes from Photorhabdus Luminescens. To co-express both luxA and luxB genes from a single promoter, we cloned as a bicistronic transcript fused with an internal ribosomal entry site (IRES). This bicistronic transcript was transfected by Superfect to HEK 293T cell line. We also transfected lux A and lux B vector to HEK 293T ...

British Library Electronic Table of Contents (United Kingdom)

Sphere-forming abilities in culture condition are considered a hallmark of cancer stem-like cells, which represents tumor cell invasiveness and stem-like characteristics. We aimed to show that the sphere-forming subpopulation of human malignant melanoma cell line WM-266-4 acts differently to zebrafish embryo extracts compared with their bulk counterpart. Spheres were maintained in neural stem cell culture conditions. The embryos of zebrafish at specific developmental stages were collected and the extracts were purified under 100 kDa. Spheres were treated with embyo extracts and proliferation assay and immunocytochemistry were conducted. Spheroid cells expressed nestin and epidermal growth factor receptor (EGFR) but not melanoma antigen recognized by T-cells (MART)1, indicating their stem-l...

British Library Electronic Table of Contents (United Kingdom)

Immune function is critical in health and disease. The control and regulation of immune reactions is an area of intense investigation that has important implications for allogeneic hematopoietic cell transplantation. Immune reactions are regulated in a number of important ways. Compartmentalization of immune responses and the production of both pro-inflammatory and anti-inflammatory cytokines play a major role. More recently several populations of T cells that regulate immune responses termed regulatory T cells have been identified. This manuscript will focus on CD4^+CD25^+FoxP3^+ natural regulatory T cells (T"r"e"g) and @a@bTCR^+CD4^+NK1.1^+ natural killer T (NK-T) cells which both suppress graft vs host disease but appear to function by distinct mechanisms.

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A 33-year-old male of proven fertility suffered six attacks of malaria while resident in an African country. For this he received anti-malarial drugs. Semen analysis performed after the fourth attack, and repeated during the following 2 years after his return to Israel, revealed severe oligozoospermia, necrozoospermia and occasionally even azoospermia. Immunological examination of the patient revealed an inverse ratio of T-cell subsets and mast cell degranulation in response to palludrin. Twenty-five months after the last attack of malaria a significant improvement was found in semen quality and there was an increase in the ratio of T-helper to T-suppressor cytotoxic cells. These observations indicate that although malaria and its treatment may affect spermatogenesis, recovery may be expected eventually. PMID:3500921

International Nuclear Information System (INIS)

Two candidate small interfering RNAs (siRNAs) corresponding to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike gene were designed and in vitro transcribed to explore the possibility of silencing SARS-CoV S gene. The plasmid pEGFP-optS, which contains the codon-optimized SARS-CoV S gene and expresses spike-EGFP fusion protein (S-EGFP) as silencing target and expressing reporter, was transfected with siRNAs into HEK 293T cells. At various time points of posttransfection, the levels of S-EGFP expression and amounts of spike mRNA transcript were detected by fluorescence microscopy, flow cytometry, Western blot, and real-time quantitative PCR, respectively. The results showed that the cells transfected with pEGFP-optS expressed S-EGFP fusion protein at a higher level compared with those transfected with pEGFP-S, which contains wildtype SARS-CoV spike gene sequence. The green fluorescence, mean fluorescence intensity, and ...

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Authors retrospectively analyzed the CT findings of mediastinal lesions in surgically or clinically confirmed 37 cases at Kosin Medical College during recent 4 years from September 1979 to August 1983. 1. Among 37 caes, malignant lymphoma were 7 cases, thymoma and vascular lesion or anomaly were 5 cases respectively, benign teratoma and tuberculous mediastinal lymphadenitis and neurogenic tumor were 4 cases respectively, pericardial cyst were 2 cases, bronchogenic cyst, non-specific cyst, pancreatic pseudocyst, mesothelioma, Bochdalek hernia was 1 case respectively. 2. The sex ratio between male and female was about 1 : 1 and the majority of the patients with malignant lymphoma and teratoma was under 20 years old. 3. CT findings of the each mediastinal lesion. 1) Primary mediastinal malignant lymphoma. (1) A large, matted, continuous and midline-crossing mass was observed in the superior and the anterior mediastinums in all ...

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Two children with cutaneous lymphoma and leukemia who were treated with total skin electron beam therapy (TSEB) are described here. Patient 1. A 7-year-old boy was admitted because of a mass over the bilateral parotis and anemia. The white blood cell count on admission was 5,000/ul. Bone marrow examination revealed 70 per cent monoblasts (M5a type by FAB classification). Complete remission was obtained following the regimen of daunomycin, cytosine arabinoside, 6-mercaptopurine and prednisolone. He was again admitted because of a skin nodule on the left thigh 19 months after initial diagnosis. A biopsy of the skin nodule demonstrated monoblastic infiltration. He received 20 Grays (Gy) to the left thigh and this led to resolution of the skin nodule. At that time, other skin nodules appeared on the right upper and lower extremities. He was treated with TSEB. Daily doses of 1 Gy were given twice a week with a 4 MeV electron beam and a total dose of 10 Gy was ...

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The serum levels of ferritin in 394 patients, including 339 patients with various malignant tumors and 23 with various non-malignant diseases, and 32 healthy subjects were determined. The normal levels of ferritin were 82.7 +- 42.3 ng/ml for males and 42.0 +- 36.9 ng/ml for females. The positive ratio of serum ferritin level was 28% in patients with malignant tumors and 22% in patients with non-malignant diseases. The usefulness of serum ferritin assay in screening for malignant tumors appeared to be limited. High serum levels of ferritin were found in patients with malignant lymphoma (positive ratio: 42%), pulmonary cancer (38%) and esophageal cancer (37%). According to the histological types, epidermoid cancer appeared to produce a higher serum level of ferritin than adenocarcinoma in patients with pulmonary cancer. It was interesting that malignant lymphoma had a high serum level of ferritin in spite of its low serum level of CEA. Carcinoma ...

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Large-scale field tracer experiments have been conducted on Ulchin and Wolsung nuclear sites for the purpose of validating FADAS and of analyzing the environmental characteristics around the nuclear site. The most influential factor in atmospheric dispersion is the meteorological condition. During the experiment, meteorological data were measured on the release point and the selected positions among sampling points. Once radioactive materials are released to the atmosphere, members of public may be exposed through the environmental media such as air, soil and foods. Therefore, to protect the public, adequate countermeasures should be taken at due time for those exposure pathways. Both processes of justification and optimization are applied to a countermeasure simultaneously for decision-making. The work scope of biological research for the radiation protection had contained the search of biological microanalytic methods for the assessment of health effect by radiation and toxic agents, ...

International Nuclear Information System (INIS)

The Thomsen-Friedenreich (T) antigen, #betta#-D-Gal-(1->3)-#alpha#-D-GalNAc, is exposed in reactive form on many human adenocarcinomata, but not on corresponding benign tissues. Peanut lectin (PNA) has a strong binding affinity for the T antigen and reportedly binds preferentially to certain malignant tissues. We investigated the potential of radio-labelled PNA as a tumour localising agent in an animal model system using a mouse lymphoma (RI) shown to bind fluorescein-labelled PNA in vitro. The radio-iodinated lectin showed good tumour localisation and rapid blood clearance. Clear images of tumours were obtained, in serial scintigraphic imaging, by 24 and 48 h. No blood background subtraction was necessary. Biodistribution studies revealed tumour to blood ratios in mice were 6:1 (at 24 h) and 17:1 (at 48 h), and tumour to muscle ratios were 34:1 (at 24 h) and 40:1 (at 48 h). Rapid in vivo breakdown of _1_2_5I-PNA led to some localisation of free iodide in the ...

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A tk{sup +/-} mouse embryonic stem (ES) cell line, designated 1G2, has been created in which one allele of the thymidine kinase (tk) gene was inactivated by targeted homologous recombination. This line is an analog of the mouse lymphoma tk{sup +/-} L5178Y cell line, which is used widely to assess the mutagenicity of chemical agents. Treatment of 1G2 cells with the alkylating agent N-ethyl-N-nitrosourea (ENU) resulted in a dose-related increase in tribluorothymidine-resistant colonies. Mutant frequencies of 152 and 296 per 10{sup 6} cells were determined for 0.1 and 0.3 mg/ml doses of ENU, compared with a spontaneous mutant frequency of 15 per 10{sup 6} cells. The data indicate that tk{sup +/-} 1G2 ES cells may be useful for the creation of a transgenic mouse model for assessing in vivo mutation using an endogenous autosomal gene. 45 refs., 2 figs., 1 tab.

International Nuclear Information System (INIS)

Interleukin 2 (IL-2) is a T-cell-derived lymphokine critical in the activation and proliferation of T cells, B cells, and lymphokine-activated killer cells. It is a glycoprotein of #approx#15,500 daltons that is synthesized and secreted after activation by antigen or mitogen. By using the analogs 8-azidoadensoine 5'-[#gamma#-"3"2P]triphosphate ([#gamma#-"3"2P]8N_3ATP) and nicotinamide 2-azidoadenine [adenylate-"3"2P]dinucleotide ([#alpha#-"3"2P]2N_3NAD"+) as photoaffinity probes, the authors have detected specific, metal ion-requiring nucleotide binding sites on recombinant human IL-2 (rhIL-2). The specificity of these nucleotide interactions with rhIL-2 was demonstrated by saturation effects and by competition by the parent nucleotides at physiologically relevant concentrations. Saturation of photoinsertion into rhIL-2 occurred at 50 #mu#M [#gamma#-"3"2P]8N_3ATP. Saturation of photoinsertion with [#alpha#-"3"2P]2N_3NAD"+ was observed at 180 #mu#M. The extent of ...

International Nuclear Information System (INIS)

High quality "3"1P MR spectra (signal to noise ratio (S/N) approximately 18, 15 min acquisition for each spectrum) were consistently obtained with surface coils over a period of 6-week RT. Both transient and steady state alterations in metabolites in response to RT were found in this case. The transient changes occurred during the first 3 hr immediately after the 3rd fractionated RT, these changes include the transient elevation of the PCr resonance, a decrease in PDE and an increase in intracellular pH. The monitoring showed that the metabolites approached steady state approximately 2 hr after the fractionated radiation intervention, suggesting that in vivo MRS can be useful for studying the dynamics of tumor response to RT such as repair of potential lethal damage, growth delay, and reoxygenation etc. The steady-state MR spectra showed the net response to each intervention and can clinically be useful for predicting and measuring the result of the fractionated RT. In this case study, ...

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In an extended case report, we discuss four cases with masses in the lacrimal fossa representing the most important entities in this region (lymphoma, pleomorphadenoma, inflammatory pseudotumor, and malignant epithelial tumor). The different indications for CT and MRI are explained. For the differential diagnosis of lacrimal gland lesions, the following imaging parameters are important: The shape of the lacrimal gland, the inner structure, the degree of contrast enhancement, and the surrounding bony structures. In the evaluation of the expansion of lacrimal gland lesions, CT in thin slices with multiplanar reconstructions is equal to MRI. However, the contrast-enhancement of lacrimal glands is better evaluated with MRI than with CT. The bony structures are better visualized on CT than on MRI. (orig.) [Deutsch] In einem erweiterten Fallbericht wird ueber die vier grossen Entitaeten bei Traenendruesenraumforderungen berichtet (Lymphom, pleomorphes Adenom, ...

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No abstract prepared.

Science.gov (United States)

PMID:10488815

UK PubMed Central (United Kingdom)

IntroductionWe report an unusual presentation of primary biliary cirrhosis.Case presentationWe present the case of a 66-year-old white British woman...Full Text Available

Transactions and Proceedings of the Royal Society of New Zealand 1868-1961

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International Nuclear Information System (INIS)

This publication is the collection of the paper presented at the title meeting. The 19 of the presented papers are indexed individually. (J.P.N.)

UK PubMed Central (United Kingdom)

Presented here is a case of a young woman, with an undiagnosed osteoid osteoma of the spine, which presented with painful scoliosis in adolescence and was treated by bracing until her accession to adulthood....Full Text Available

UK PubMed Central (United Kingdom)

Two infants were seen with severe ascites detected before birth, a previously unreported presentation of Niemann-Pick disease type C. In the second infant no diagnostic storage cells were present in...Full Text Available

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Separate abstracts are prepared for 74 papers presented at the conference. M.B. Carver, Program Chairman, presented an overview of the meeting. (MCW)

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This presentation details how wind turbine gearboxes fail to meet 20-year design life and how the Gearbox Reliability Collaborative (GRC) is addressing the challenges.

UK PubMed Central (United Kingdom)

Primary cardiac angiosarcoma is a rare cardiac tumor. The initial clinical course is often asymptomatic, and metastatic disease is present in a majority of affected patients at diagnosis. We present...Full Text Available

UK PubMed Central (United Kingdom)

Central airway obstruction (CAO) is a serious presentation of lung cancer and associated chest diseases. It presents a real challenge to the anesthesiologist because usually the patient admitted to...Full Text Available

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A summary is presented of research being carried out in Thailand on the preparation of irradiation-impregnated wood.

International Nuclear Information System (INIS)

(1973). USSR Ovcharenko, AM Nedavnij, OI Kapranov, BI Tomskij

Wastenet

The paragraph shall start with a simple declarative sentence in bold font that presents the subject matter

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Program activities and achievements in 1982 of the geodynamic program are summarized. The significant results presented are summarized.

Science.gov (United States)

Photographs are presented of the FFTF reactor facility, components, and some materials.

Medline Plus

... presentation will be archived on the OR-Live website. 00:46:02 ANNOUNCER: This has been a ...

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A discussion is presented of the chemistry and technology of coal liquefaction and the physics and technology of coal desulfurization. 31 refs.

KoreaScience (Korea)

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UK PubMed Central (United Kingdom)

Urethral duplication is a rare congenital anomaly of the lower urinary system and has varied presentation. According to the Effmann classification, type IIA2-Y urethral duplication is charcterized by...Full Text Available

International Nuclear Information System (INIS)

This talk summarizes recent progress in top quark physics studies for high energy linear electron-positron colliders as presented at the LCWS2000 Workshop at Fermilab. New results were presented for top pair production at threshold and in the continuum, as well as for top production at #gamma##gamma# colliders.

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Performance and operating characteristics are presented for a solar powered aircraft intended to remain aloft for long periods. The critical technologies which limit the performance are identified. By using the techniques presented, the effects of variation in the system parameters are studied. Practical design consideration are discussed.

UK PubMed Central (United Kingdom)

Data on a technique for the detection of antigen from arthropod vectors in a dot immunobinding assay are presented. In this system, antigen present in the vector was first solubilized in sodium dodecyl...Full Text Available

Science.gov (United States)

Mass Balance and Present-day Antarctic Rebound and Gravity Change. Erik R. Ivins , Eric Rignot, Xiaoping Wu, Carol A. Raymond (JPLKaltech, 300-233,4800 Oak ...

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Research programs, presented at the contractor's review meeting on indirect liquefaction, are presented on the following topics: oxygenates (methanol) synthesis; Fischer-Tropsch synthesis; product upgrading; and process support engineering evaluations. A total of 18 reports are included. Individual projects are processed separately for the data bases. (CBS)

UK PubMed Central (United Kingdom)

Protection from extinction of conditioned fear has been demonstrated when a conditioned inhibitor of fear is presented during extinction treatment. The present study assessed if similar results...Full Text Available

International Nuclear Information System (INIS)

Physics and technology of free electron laser (FEL) are reviewed. Mechanisms of stimulated emission in FEL and its present status and future prospects are presented. Electromagnetic wiggler, two stage FEL and so on are also interpreted. Finally, accelerators and wigglers for FEL, recent FEL experiments and FEL applications are noted. (author).

Science.gov (United States)

The evolution of the Doublet III neutral beam armor is followed from the initial design of a radiation cooled metallic tile to the present actively cooled graphite design. Results of the thermal and stress analyses that dictated the present design are reviewed.

Science.gov (United States)

This section presents background information supporting the development of effluent limitations guidelines and standards for the concentrated aquatic animal production (CAAP) point source category. Section 1.1 presents the legal authority to regulate the ...

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A method for calculating plume rise above stack level is presented. The equations set forth by Briggs, which are presently the most popular for such calculations, are discussed. A method using 2 nomographs, simplifying the calculations is given. (JMT)

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Risoe`s 40th anniversary was celebrated June 3, 1998 by a symposium held at Risoe. The interaction of research at Risoe with academia and industry was presented in both national and international perspective. Most of the presentations are in English, a few in Danish. (au)

Science.gov (United States)

Software verification is recognized as an important and difficult problem. We present a norel

CERN Document Server

This paper presents a model of the dynamics of the wage income distribution.

Science.gov (United States)

sharing data and computational resources, and accessing information in digital libraries." Bill Wulf (1989) In a Collaboratory, the presentation/meeting concept embodied...

International Nuclear Information System (INIS)

The conventional treatment of quantum field theories including tachyons is presented, in particular the phi"4 theory. (W.D.L.).

Science.gov (United States)

Seven papers were presented at the meeting. A separate abstract was prepared for each paper. (LCL)

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Two nomographs are presented which enable the volumes of a conical pile and an oblong pile of bulk material to be determined.

Energy Technology Data Exchange (ETDEWEB)

The present paper is concerned with the prediction method for the motions and tensions of mooring lines on slack-moored floating oceanic architectural building in coastal zone. The motions and the tensions of mooring lines were estimated by the time domain numerical simulation in the present method. The present method includes the nonlinearity of mooring system, slow varying wave drift force. The authors performed a time domain numerical simulation for motions and the tensions of mooring lines on floating barge in two component waves. Also, the results obtained by numerical simulation were compared with the experimental results. The validity of the present method was confirmed.

Science.gov (United States)

... presented in this paper can be said to be truly three dimensional as opposed to other reported work that uses symmetric boundary conditions. ...

Science.gov (United States)

Featured Collections Featured collections are information sources that use federated search or are known for presenting exceptional, authoritative information for...

Science.gov (United States)

... The realization of directional audio technology in the cockpit may reduce visual workload, enhance the presentation of flight and threat information ...

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The present state of investigations into the fragmentation of target nuclei by particles and nuclei of intermediate and high energies is reviewed.

International Nuclear Information System (INIS)

Certain radioiodine containing esters useful as brain imaging agents are disclosed. The formula of these compounds are presented.

Science.gov (United States)

... Pagination or Media Count : 205. Abstract : Present methods for planning reliability improvement of launch vehicles are reviewed. ...

Science.gov (United States)

Computer And Network Security: Information For Everyone: This presentation was originally prepared as the 14th talk in a series known as "The Programmer's ...

Science.gov (United States)

A post-accident-heat-removal structural effects analysis for the steel liner in the FFTF concrete containment structure is presented. (JWR)

International Nuclear Information System (INIS)

This report presents criteria for the identification and evaluation of fire hazards in nuclear power stations. The report presents criteria that are consistent with the existing regulatory approach in Canada, and outlines engineering tools and analytical techniques currently available to deterministically analyse fire. The criteria presented cover the topics which should be included in a fire hazard analysis and provide details of each topic so that the accuracy of an analysis may be evaluated.

International Nuclear Information System (INIS)

In this retrospective study, 28 cases of Ewing's sarcoma are reviewed for the onset of metastasis. Bone scans demonstrated bone metastasis in three out of 28 patients at presentation. Of the 22 patients free of metastases at presentation, ten subsequently developed bone metastases. In six of these patients, the bone scan was the earliest demonstrator of metastatic disease. Bone scans are recommended at presentation and periodically during follow-up.

UK PubMed Central (United Kingdom)

We report the presence of oligosaccharide structures on a glutamine residue present in the V_L domain sequence of a recombinant human IgG2 molecule. Residue Gln-106, present in the QGT sequence...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

An interpretive theory of trace impurity transport in tokamaks is presented. It is based on an earlier phenomenological approach developed by the authors for describing tokamak plasma transport experiments. The present model is used to explain disparate phenomena observed in ALCATOR C and DITE in a unified phenomenological framework. Predictive numerical calculations are presented for DITE conditions. If experimentally confirmed, the model could be used to correlate plasma properties with trace impurity behaviour. (orig.)

International Nuclear Information System (INIS)

O.K. Andersen has recently introduced a linear augmented plane wave method (LAPW) for the calculation of electronic structure that was shown to be computationally fast. A more general formulation of an LAPW method is presented here. It makes use of a freely disposable number of eigenfunctions of the radial Schroedinger equation. These eigenfunctions can be selected in a self-consistent way. The present formulation also results in a computationally fast method. It is shown that Andersen's LAPW is obtained in a special limit from the present formulation. Self-consistent test calculations for copper show the present method to be remarkably accurate. As an application, scalar-relativistic self-consistent calculations are presented for the band structure of FCC lanthanum. (author).

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A summary of the 1983 Critical Solvent Deashing unit performance at the Wilsonville Advanced Coal Liquefaction R and D Facility is presented. All periods of on feed operation, unscheduled shutdowns, and scheduled shutdowns are accounted for and tabulated. Causes of unscheduled shutdowns are identified and discussed. Details of repeated, major maintenance problems with various pieces of equipment are presented. Where applicable, solutions are discussed. Historical operations and maintenance data are presented and used for comparison purposes in order to better indicate areas of improvement in the unit. 4 references, 7 figures, 3 tables.

Science.gov (United States)

>The causes and implications of the impeading shortages of gasoline, heating oil, diesel fuel, jet fuel, and electricity were investigated at the May 3, 1973 hearings. Discussions and related data were presented on short-term fuel shortages and their effects on the electric utilfties and the present situation in the regulated energy industries and its effects on energy R&D. The statement of the national oil lobbers council is presented in an appendix. (MCW)

Energy Technology Data Exchange (ETDEWEB)

The Second International Workshop on Human Chromosome 9 was held in Chatham, Massachusetts on April 18--20, 1993. Fifty-three abstracts were received and the data presented on posters. The purpose of the meeting was to bring together all interested investigators working on the map of chromosome 9, many of whom had disease-specific interests. After a brief presentation of interests and highlighted results, the meeting broke up into the following subgroups for production of consensus maps: 9p; 9cen-q32; 9q32 ter. A global mapping group also met. Reports of each of these working groups is presented in the summary.

Energy Technology Data Exchange (ETDEWEB)

This document presents the proceedings of the Areva technical days, presented during the session 5 the 9 and 10 december 2004, at Istanbul. It deals with the operations of the transmission and distribution division. With manufacturing facilities in over 40 countries and a sales network in over 100, Areva offers customers technological solutions for nuclear power generation and electricity transmission and distribution (the Group also provides interconnect systems to the telecommunications, computer and automotive markets). It provides five topics: a general presentation of Areva, the strategic stakes for transmission and distribution by world-zone, economic and strategic stakes of business unit products, business unit systems and business unit automation. (A.L.B.)

Energy Technology Data Exchange (ETDEWEB)

Approximate methods are presented for solving nonlinear boundary value problems with an unknown (free) boundary, such as the Stefan problem in heat conductivity. Examples of this kind of problems in thermal physics, hydrodynamics, elasticity, and plasma physics are examined. Attention is given to the principal computational methods for solving stationary problems for second- and fourth-order elliptic equations, such as the domain transformation and penalty methods. To illustrate the capabilities of the methods presented here, examples of numerical solutions are presented for various specific applied problems. 255 references.

International Nuclear Information System (INIS)

Focussed ion beam (FIB) technology has the advantage of being a maskless process compatible with UHV processing. This makes it attractive for use in in situ processing and has been applied to the fabrication of various mesoscopic structures. The present paper reviews these results whilst putting emphasis on in situ processing by a combined FIB and molecular beam epitaxy system. The typical performance of present FIB systems is also presented. In order to utilize the potential advantages of FIB processing, reduction of damage and improvement of throughput are important, and much effort has been devoted to developing processing techniques which require a reduced dose. The importance of low-energy FIB is discussed. (author).

Energy Technology Data Exchange (ETDEWEB)

This book presents in simple terms the basis of molecular genetics and how it is used to obtain an understanding of the human genome. The author's central focus is the transistion of genetics from statistics to experimental manipulations, and he offers analogies that help readers visualize the genome, thereby avoiding conventional scientific presentations. He illustrates how genetics is used in scientific laboratories, in courtrooms, and in hospitals. Little is presented about the complex social and ethical issues raised by the Human Genome project.

International Nuclear Information System (INIS)

This paper is concerned with the determination of a unique scaling parameter in complex scaling analysis and with accurate calculation of dynamics resonances. In the preceding paper we have presented a theoretical analysis and provided a formalism for dynamical resonance calculations. In this paper we present accurate numerical results for two non-trivial dynamical processes, namely, models of diatomic molecular predissociation and of barrier potential scattering for resonances. The results presented in this paper confirm our theoretical analysis, remove a theoretical ambiguity on determination of the complex scaling parameter, and provide an improved understanding for dynamical resonance calculations in rigged Hilbert space.

British Library Electronic Table of Contents (United Kingdom)

A method for automatic optimal feeder design in steel casting processes is presented. The initial design is the casting part (without feeders) which is placed in a suitable mold box. Design of each feeder contains the following steps: determination of the feeder-neck connection point on the casting surface, initial feeder design, feeder shape optimization and feeder topology optimization. Completing designing the first feeder, the method attends to designing the next one, if it is required, and the same procedure will be repeated. In the presented method, feeders are designed in a descending order of their sizes. The feasibility of the presented method is supported with an illustrative example.

Science.gov (United States)

Ever-present water vapor and dust distort or block incoming radiations. ... were among the first scientific sensors to be attached to the earliest space rockets. ...

UK PubMed Central (United Kingdom)

A case of xanthogranulomatous salpingitis (XGS) associated with a large uterine leiomyoma in a 50-year-old woman is presented. Xanthogranulomatous inflammation is an uncommon form of chronic inflammation...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This Fact Sheet presents the mission of the West Valley Demonstration Project and information on the 1994 pollution prevention and recycling accomplishments.

Science.gov (United States)

... This must be taken a step further in counseling and other feedback and ... Record System Power Point Presentation ,www.armyppt.com/ncoer/6.htm ...

UK PubMed Central (United Kingdom)

Aim:To present three patients with ocular disease who developed a range of complications following use of traditional medications.Settings...Full Text Available

UK PubMed Central (United Kingdom)

The protocols presently established for optimum seed storage do not account for the chemical composition of different seed species, the physiological status of the seed, and the physical status of water...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The article presents briefly the plans of the British Petroleum Oil Company for a new hydrogen power plant that includes an offshore platform in the North Sea.

UK PubMed Central (United Kingdom)

Evidence for the presence of undecaprenol in the unsaponifiable lipid of Lactobacillus plantarum (N.C.I.B. 6376) is presented. Characterization of the compound was based mainly on...Full Text Available

CERN Document Server

We present results on searches for exotic particles (relativistic magnetic monopoles and WIMPs) and for UHE neutrinos, obtained with the Baikal neutrino telescope NT200.

Energy Technology Data Exchange (ETDEWEB)

The article has three sections. The first discusses the environmental problems the tanker traffic poses to the Norwegian coastal waters and shores. Various precautionary measures and requirements are briefly presented. The size of the present marine transportation and the future Russian marine petroleum activity in the Barents area are briefly mentioned. The second named, conflicting exploration drilling, presents the conflicting interests regarding exploratory drilling in the Barents Sea in Norway. The environmental problems are large and have lead to an on-going reevaluation. Some pollution abatement measures are mentioned. The regional economic development is briefly outlined. The third deals with the Norwegian governmental safety activities and presents a brief survey of the official safety activities in the petroleum sector in Norway and the international cooperation particularly with the Russian ...

UK PubMed Central (United Kingdom)

Sinonasal malignancy is a cause of otorhinolaryngologic morbidity and mortality in West Africa. However, there is a dearth of information in the literature on its clinicopathologic presentation in West...Full Text Available

UK PubMed Central (United Kingdom)

Increasing evidence suggests that sex differences exist in the etiology, presentation, treatment, and outcome from stroke. The reasons for these sex disparities are becoming increasingly explored, but...Full Text Available

UK PubMed Central (United Kingdom)

Purpose:Formal presentations are a common requirement for students in health professional programs, and evaluations are often viewed as subjective. To date, literature describing...Full Text Available

UK PubMed Central (United Kingdom)

Recurrence of microbial keratitis in the presence of protozoal infection is very rare and infrequently reported unless predisposing factors are present. The association of recurrent microbial keratitis...Full Text Available

Science.gov (United States)

May 18, 2007 ... This exciting new development in neutron star evolution was presented at the Winter 2004 AAS Meeting in Atlanta, Georgia. ...

Science.gov (United States)

... these estimates were obtained from these and the parameter covariance matrix using a parametric bootstrap method. We present the ... ...

UK PubMed Central (United Kingdom)

Background/Aim:To assess the prognostic indicators preoperatively presenting and influencing the mortality rate following esophagectomy for esophageal cancer.Full Text Available

Science.gov (United States)

In APCs, presentation by MHC II molecules of the chemically dominant peptide from the protein hen egg white lysozyme (HEL) generates different conformational isomers of the peptide-MHC II complexes (pMHC). Type B pMHCs are formed in early endosomes from exogenous peptides in the absence of H2-DM, whereas in contrast, type A pMHC complexes are formed from HEL protein in late vesicles after editing by H2-DM. Thus, H2-DM edits off the more unstable pMHC complexes, which are not presented from HEL. In this study, we show that type B pMHC complexes were presented from HEL protein only after stimulation of dendritic cells (DC) with TLR ligands or type I IFN. Type I IFN contributed to most TLR ligand-induced type B pMHC generation, as presentation decreased in DC lacking the receptor for type I IFNs (IFNAR1(-/-)). In contrast, presentation of type A pMHC from HEL and from peptide was ...

Science.gov (United States)

... Pollimyrus adspersus is only known from Boma and Matadi, Lower Congo River basin and from the Lilanda ... Africa: Pollimyrus adspersus is present at Boma and Matadi, Lower Congo River basin and in the L...

Energy Technology Data Exchange (ETDEWEB)

We show that, for the high electron currents used in present-day free-electron lasers, spontaneous radiation is distributed according to thermal statistics.

Energy Technology Data Exchange (ETDEWEB)

The aim of this paper is to present the phase-space properties of the systems that contain bradyons, luxons and tachyons. It is shown that particularly at low energy, these properties are quite different from the well-known properties of bradyons.

International Nuclear Information System (INIS)

Data on French nuclear electricity generation sites, nuclear power plant operations personnel, operation simulators, nuclear training centers and training statistics are presented.

Energy Technology Data Exchange (ETDEWEB)

Detailed level and decay schemes are presented for the nuclei of the A = 101 mass chain. The level properties obtained from decay and reaction experiments are shown in the drawings. Experimental methods, references, and comments are given in the text.

Energy Technology Data Exchange (ETDEWEB)

Nomographs are presented that estimate the evaporation loss from external floating-roof tanks using tank diameter, type of seal, product vapor pressure, and wind velocity.

International Nuclear Information System (INIS)

The energy level schemes of tin isotopes produced in the heavy ion reactions are presented. The using of #gamma# spectroscopy technique is also described. 4 refs, 12 figs.

Science.gov (United States)

... This paper presents our research in neural learning for predicting ... Denote this feature set as F4. ... can be observed that the SOC curves generated by ...

Science.gov (United States)

... sample. Hosoitalization Data Hospital admission rates across Navy ships :.n 1985 and 1975 are presented in Table 17. ...

International Nuclear Information System (INIS)

The flight line profile data and statistical analysis results for the Port Alexander Quadrangle in southeast Alaska are presented.

Science.gov (United States)

nances, an iron ore sintering plant, and several fuel oil boilers.***. The use of undemonstrated technology presents problems for evaluatingi ...

Energy Technology Data Exchange (ETDEWEB)

I present and discuss recent results on nuclear forces and few-nucleon systems obtained in the framework of chiral effective nuclear field theory.

Energy Technology Data Exchange (ETDEWEB)

The present invention describes surfactants of formula (I), ##STR00001## wherein R, R.sub.N, and m are defined herein, processes for their preparation, and methods for their decomposition.

UK PubMed Central (United Kingdom)

In recent years increasing evidence is pointing toward white matter abnormalities in schizophrenia and other psychiatric disorders. The present paper will provide an overview over the role of...Full Text Available

Science.gov (United States)

Aug 18, 2004 ... The Arabian Gulf region presents a challenge to meteorologists trying to simulate weather with computer models because sea-surface and land ...

UK PubMed Central (United Kingdom)

The present study investigated the association of mothers’ marriage and changes in young adolescents’ cognitive and socioemotional development and changes in family processes....Full Text Available

UK PubMed Central (United Kingdom)

The present study describes an efficient chemoenzymatic method for introducing a core N-glycan of glycoprotein origin into various lipophilic natural products. It was found...Full Text Available

International Nuclear Information System (INIS)

It is an object of the present invention to provide an improved installation having a pressurized fluid circuit incorporating fluidic brakes for restricting fluid flow through a breach of the installation. (author).

UK PubMed Central (United Kingdom)

Objective:The present study describes the effect of nebivolol (NBV) either alone or in combination with lamotrigine (LTG) using increasing current electroshock seizures...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The present recent measurements of the inclusive cross section of W and Z bosons from Run II of the Fermilab Tevatron collider.

Energy Technology Data Exchange (ETDEWEB)

This poster presentation covered a number of issues related to the new regulations concerning information on new substances derived from the Canadian Environmental Protection Act (CEPA). The authors described the background, and the objectives of the research project. A brief overview of the Acid Mine Drainage (AMD) process was provided, as well as the sulphate reduction process. The general methodology was explained, and the results of the bioactivation presented. The process followed for the bioaugmentation and the results obtained were presented. The regulations concerning information on new substances derived from the CEPA were described. The authors then presented their conclusions and perspectives. 26 figs.

UK PubMed Central (United Kingdom)

Microcalcifications are an important diagnostic marker for breast cancer on mammograms, yet the mechanism of their formation is poorly understood. Indeed, there is presently no short-latency,...Full Text Available

Science.gov (United States)

... WHS- Washington Headquarters Service ... present a framework based on political campaigns theory for both the Joint Task Force Commander down ...

Energy Technology Data Exchange (ETDEWEB)

The most profitable terrain in Romania is already sold. Investors are now looking for new wind power sites. The contribution presents details. (orig.)

International Nuclear Information System (INIS)

We develop the notions of fusion for representations of the WA_2 algebra along the lines of Feigin and Fuchs. We present some explicit calculations for a WA_2 minimal model. (orig.).

Science.gov (United States)

flow separation occurred at the junction of the tip fin and the fuselage. ...... Systems, presented at the AGARD Guidance and Control and Flight Mechanics ...

UK PubMed Central (United Kingdom)

The processes of neuronal outgrowth and guidance have typically been studied in classic 2D cell culture systems that do not recapitulate topographical cues present in the in vivo extracellular matrix...Full Text Available

Science.gov (United States)

and the implications for massive star evolution. In recent years, the complex nature of the circumstellar regions of evolved massive stars has become apparent. ...

International Nuclear Information System (INIS)

The document presented defines the plan to be used to coordinate the preparation, review, approval, and issuance of the operating procedure documents required to ensure safe and efficient operation of FFTF.

Energy Technology Data Exchange (ETDEWEB)

A numerical model for the development of bed dominated scour around sub-sea structures is presented. The hydrodynamic part of the model is based on a modified potential flow theory. The purpose of the present study has been to develop relatively simple models, yet complex enough to capture the main physics that can be used as engineering tools. An overview of scour phenomena and the basic problems of scour in steady current flow is presented. A hydrodynamic model for horseshoe vortex is presented, as well as a model for the bed transport, and examples are given. The scour in oscillatory flow and a curvilinear model for suspended sediment calculations are described. An advection-diffusion model (formulated in a curvilinear stretched coordinate system) has been developed and is described in an article which has been submitted for publication, a copy of the article is enclosed in Appendix E of the report. ...

UK PubMed Central (United Kingdom)

Insect growth regulators (IGRs) are a class of new chemicals that interfere with maturation and reproduction in insects. Proposed hypotheses on the biochemical mechanism of action are presented herein....Full Text Available

International Nuclear Information System (INIS)

The development and occurrence of new electron accelerators and applications are according to the human society development law, as a whole. The period of economic standstill is generating an intense creative activity in the domain of science and engineering which also resulting in great achievements in the field of electron accelerators. This paper presents the basic principle of the electron beam applications and the accelerators required characteristics for their present and potential applications in the domains: radiation sources, diagnostics, radiation processing, energetics, environment, defense and basic sciences. All these are correlated to the new generation of accelerators which, for the acceleration process, may employ electromagnetic fields generated by standard sources, atomic lasers, free electron lasers, Cerenkov effect, Smith - Purcell effect, electron beams, plasma, excited atoms into a crystal or other sources. Some more ...

UK PubMed Central (United Kingdom)

BackgroundThe aim of this report was to describe duodenal obstruction caused by a rubber foreign body in a cow.Case PresentationThe clinical, biochemical...Full Text Available

UK PubMed Central (United Kingdom)

The economics of medical computer networks are presented in context with the patient care and administrative goals of medical networks. Design alternatives and network topologies are discussed with...Full Text Available

International Nuclear Information System (INIS)

The diagnostic designs for the Laser Megajoule (LMJ) will require components to operate in environments far more severe than those encountered in present facilities. This harsh environment will be induced by fluxes of neutrons, gamma rays, energetic ions, electromagnetic radiations, and, in some cases, debris and shrapnel, at levels several orders of magnitude higher than those experienced today on existing facilities. The lessons learned about the vulnerabilities of present diagnostic parts fielded mainly on OMEGA for many years, have been very useful guide for the design of future LMJ diagnostics. The present and future LMJ diagnostic designs including this vulnerability approach and their main mitigation techniques will be presented together with the main characteristics of the LMJ facility that provide for diagnostic protection.

UK PubMed Central (United Kingdom)

Design of the software architecture for a knowledge driven HIS is presented. In our design the frame has been used as the basic unit of knowledge representation. The structure of the frame is being...Full Text Available

Science.gov (United States)

... 66. BV Sankar and MA Pinheiro, "An Offset Beam Finite Element for Fracture Analysis of Delaminations," AIAA Paper Number 90-1024-CP, 31st ...

International Nuclear Information System (INIS)

(1979). United States Bernsen, SA Bechtel Power Corp-USA, Downey, CA

UK PubMed Central (United Kingdom)

BackgroundPublicly available DNA sequence databases such as GenBank are large, and are growing at an exponential rate. The sheer volume of data being dealt with presents serious...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Recommendations of the Advisory Committee on Reactor Safeguards are presented to the Commissioners for their consideration for FY 83 budget for the NRC safety research program.

Science.gov (United States)

He said, I had heard of Cloud Computing when I was in grad school, but they had presentations on it at EclipseCon. I was sold that it was something that ...

UK PubMed Central (United Kingdom)

The pleiotropic actions of neuromodulators on pre- and postsynaptic targets present challenges to disentangling the mechanisms underlying regulation of synaptic transmission. Within the striatum,...Full Text Available

Science.gov (United States)

As presented in [4], the Sigma-Point Consider Filter (SPCF) algorithm extends ... lines of the derivative-free, Sigma-Point Kalman Filter algorithm given in ...

Science.gov (United States)

Malignancies Breast Malignancies Bladder, Prostate, and Testicular Malignancies Uses of Cancer Registry Data Brain Tumor Reporting Training Materials Overview Presentation and...

UK PubMed Central (United Kingdom)

Experience gained with a wide variety of missile injuries of the brain is presented. Clinical signs and intracranial pressure (ICP) studied in the early post-injury period have been correlated with...Full Text Available

International Nuclear Information System (INIS)

Observations concerned with the formation of isothermal #omega# in the beta-titanium alloy RMI (38-6-44) are presented as part of a more general study of the aging characteristics of the alloy.

Energy Technology Data Exchange (ETDEWEB)

This report provide appropriate guidance for addressing the major technical issues associated with the design and installation of a photovoltaic-thermal (PV-T) system. Nomographs are presented for developing preliminary sizing and costing, and issues associated with specific components and the overall design of the electrical and mechanical system are discussed. SAND82-7157/2 presents a review of current PV-T technology and operating systems and a study of potential PV-T applications. Detailed PV-T system designs for three selected applications and the results of a trade-off study for these applications are presented in SAND82-7157/4. A summary of the major results of this entire study and conclusions concerning PV-T systems and applications is presented in SAND82-7157/1.

Science.gov (United States)

A method of strength analysis of short sheet-stringer panels subjected to compression is presented

UK PubMed Central (United Kingdom)

AbstractA young, male miniature poodle was presented with severe neurological problems. Laboratory tests and ultrasonograph examination were consistent with extrahepatic portosystemic...Full Text Available

UK PubMed Central (United Kingdom)

Measurements of the taste thresholds of blowflies for a wide variety of carbohydrates, presented individually and in combination, showed that the stimulating effects of the compounds are not always...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

We present a laser spectroscopic approach for measuring the charge radius of the halo nucleus {sup 11}Li and report on recent progress in the development of the experimental apparatus.

UK PubMed Central (United Kingdom)

The purpose of the present study was to prepare a novel domperidone hydrogel. The domperidone dispersion was prepared by the solvent evaporation method. The characteristics of domperidone dispersion...Full Text Available

Science.gov (United States)

High Cycle Fatigue Initiative Workshop -Active Vibration. Control/Engine. Health Monitoring Session December 10,. 1996. The presentation was titled "Active ...

UK PubMed Central (United Kingdom)

A comparison of the results of machine and human information retrieval using MEDLARS and the printed Index Medicus indicates that at present neither method is entirely satisfactory...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This book contains the abstracts of all the presentations made either in oral or poster form, at the VII International Symposium on Photosynthetic Prokaryotes.

Science.gov (United States)

Mar 1, 2011 ... heat transfer augmentation in the stagnation region is presented. The effects of free stream turbulence and surface roughness on spanwise ...

CERN Document Server

With iWork '09: The Missing Manual, you'll quickly learn everything you need to know about Apple's incredible productivity programs, including the Pages word-processor, the Numbers spreadsheet, and the Keynote presentation program that Al Gore and Steve Jobs made famous. This book gives you crystal-clear and jargon-free explanations of iWork's capabilities, advantages, and limitations to help you produce stunning documents and cinema-quality digital presentations in no time.

Energy Technology Data Exchange (ETDEWEB)

Methods of designing ultrasonic piezoelectric transducers in accord with a specified directivity pattern are analyzed and general formulas are presented for the design problem. As an example, the pressure distribution on the working surface of a circular piezoelectric transducer is determined that is capable of forming a narrow weakly divergent beam. Experimental results are presented with respected to ultrasonic fields that support the theoretical conclusions.

Energy Technology Data Exchange (ETDEWEB)

A simple and effective method is presented for the sizing and passage apportionment of multistream plate-fin heat exchangers. Methods for passage arrangement are discussed, and it is shown that a symmetric or mixed passage arrangement is more efficient than a segregated arrangement. A method for assessing the relative merits of various passage arrangements is presented. The use of the methods is illustrated through a worked example.

Energy Technology Data Exchange (ETDEWEB)

The present report concerns a research for the tritium and for the carbon 14 in lichens in a spirit of bio-indication: the first results appear in Daillant and al (2004 ) and additional results were presented to the congress B.I.O.M.A.P. in Slovenia, organized collectively by the institute Josef Stefan from Ljubljana and the international atomic energy agency from Vienna (Daillant and al 2003). (N.C.)

International Nuclear Information System (INIS)

The principal types of corrosion are presented which can occur in CANDU steam generator. There are also presented the operation conditions, the specifications referring to the water chemistry and the construction materials of Steam Generator, the factors that have a great influence on the corrosion behaviour during the whole exploitation period of this equipment. The most important elements of CANDU Steam Generator ageing management program are also discussed. (R. P.)

Energy Technology Data Exchange (ETDEWEB)

This paper is concerned with the application of a new fuzzy inference method to the design of fuzzy power system stabilizer. Based on Truth-Value-Flow-Inference (TVFI), a fuzzy logic controlled power system stabilizer is proposed to enhance the stability of power system with weak or negative damping. The design of the proposed fuzzy power system stabilizer is presented. Numerical simulation results are presented and compared with two other kinds of fuzzy power system stabilizers. (author)

Energy Technology Data Exchange (ETDEWEB)

Presented are some preliminary studies made in preparation for the design of a solar powered loop for desalination by humidification - dehumidification process. The studies concentrated on the evaluation of different parameters affecting the performance of the combination of different components in such a loop in the hope of outlining the most decisive factors for the choice or design of solar collectors or heat source. The results presented relate to the performance of two of the most important components in a loop of such purpose, that is: the humidifying and the dehumidifying columns or stacks. 4 refs.