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Hearing Loss  

Medline Plus

Full Text Available Hearing Loss Introduction Hearing problems are pretty common in older people. Around one in three people over ... will help you better understand hearing loss. Anatomy & Hearing Auricle Ear Canal Tympanic Membrane Ossicles Inner Ear ...

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Hearing Loss  

Medline Plus

Full Text Available ... notice their hearing loss while speaking on the phone. Earaches may be common if the hearing loss ... with severe hearing loss to talk on the phone. Headsets that make sounds louder or services that ...

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Hearing Loss  

Medline Plus

Full Text Available ... born with them. Other problems include tumors, infections, brain injuries, and aging. Some hearing loss is inherited and ... of hearing loss or deafness are related to brain injuries. When the part of the brain that understands ...

4

Hearing Loss  

Medline Plus

Full Text Available ... Other problems include tumors, infections, brain injuries, and aging. Some hearing loss is inherited and runs in ... hearing loss or deafness is due to the aging process. It is known as presbycusis. It starts ...

5

Hearing Loss  

Medline Plus

Full Text Available ... For patients with severe hearing loss, learning sign language can be very helpful and worthwhile. Patients undergoing ... deafness may result are encouraged to learn sign language while they are still able to hear. Summary ...

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Hearing Loss  

Medline Plus

Full Text Available ... hearing loss. Anatomy & Hearing Auricle Ear Canal Tympanic Membrane Ossicles Inner Ear Our ears are very specialized ... inside the ear to the eardrum, or tympanic membrane. 2. The middle ear, which is formed of ...

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Hearing and Hearing Loss  

Science.gov (United States)

How the ear works, and how you can prevent hearing loss! The Inner Ear Truth and Beauty A prize winning image of hair cells inside the cochlea of the inner ear Common Indoor and Outdoor Noise Levels How the ear works How the ear works with images and graphics What is noise-induced hearing loss? Turn em Down iPod's Popular Earbuds: Hip Or Harmful? Hearing Loss Simulations Hearing Loss Demo # 1 So, how do you know if LOUD is TOO LOUD? How Loud is Too Loud? Noise Induced Hearing Loss How the ear works ...

Engelman, Mr.

2009-05-27

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Hearing Loss  

Medline Plus

Full Text Available ... most patients first notice their hearing loss while speaking on the phone. Earaches may be common if ... and look at the lips of the person speaking to them. Using closed captioning helps patients with ...

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Hearing Loss  

Medline Plus

Full Text Available ... that involve the eighth nerve are called acoustic neuromas. The ossicles in the middle ear can become ... with hearing loss especially patients who have acoustic neuromas, a form of tumor. This buzzing is known ...

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Hearing Loss  

Medline Plus

Full Text Available ... actually be seen coming out of the external auditory canal. Dizziness may also accompany hearing loss, especially ... as an otoscope or even a specialized microscope. Auditory tests are usually given to determine the extent ...

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Hearing Loss  

Medline Plus

Full Text Available ... tumors that involve the eighth nerve are called acoustic neuromas. The ossicles in the middle ear can ... patients with hearing loss especially patients who have acoustic neuromas, a form of tumor. This buzzing is ...

12

Hearing Loss  

Medline Plus

Full Text Available ... auricle and the ear canal. The ear canal leads inside the ear to the eardrum, or tympanic ... Repeated infection of the middle ear can also lead to damage of the ossicles. Hearing loss and ...

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Hearing Loss  

Medline Plus

Full Text Available ... very good hearing with the help of hearing aids. Hearing aids have gotten smaller and better because of technology. ... probe and an otoscope or a microscope. Hearing aids may also be needed to make sounds louder ...

14

Hearing Loss  

Medline Plus

Full Text Available ... aids do not work, implantable hearing aids and cochlear implants may be helpful. Implantable hearing aids and cochlear implants transmit sound waves directly to the 8th nerve ...

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Hearing loss and music  

Science.gov (United States)

Noise induced hearing loss - music; Sensory hearing loss - music ... ed. Philadelphia, Pa: Mosby Elsevier;2010:chap 149. Noise-Induced Hearing Loss. National Institute on Deafness and Other Communication Disorders. ...

16

Occupational hearing loss  

Science.gov (United States)

Hearing loss - occupational; Noise induced hearing loss ... Lonsbury-Martin BL, Martin GK. Noise-induced hearing loss. In: Cummings CW, Flint PW, Haughey BH, et al, eds. Otolaryngology: Head & Neck Surgery . 5th ed. Philadelphia, Pa: Mosby Elsevier;2010: ...

17

Hearing loss - infants  

Science.gov (United States)

... the cause of hearing loss. Treatment may include: Speech therapy Learning sign language Cochlear implant (for those with ... hearing aids and other devices, as well as speech therapy allow many children to develop normal language skills ...

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Hearing loss in Diabetes Mellitus  

Directory of Open Access Journals (Sweden)

Full Text Available Background: The complex arrangement of inner ear makes it potential target of hyperglycaemic damage.A study was conducted to identify the probable occurrence of hearing loss as a complication of DiabetesMellitus (DM).Aims and objective:• To assess the hearing loss in type 2 diabetic patients and correlate with age, duration of diabetes,HbA1C.• To correlate hearing loss with nerve conduction study.Design: Cross sectional study was done involving randomly 110 Type 2 DM patients. Data regardingtheir age and duration of diabetes was collected. Pure tone Audiometry and Nerve conduction study wasdone. HbA1c level determined. Data statistically analysed using Pearson correlation coefficient.Results: Out of 110 patients 48 patients (43.6%) had bilateral Sensorineural hearing in higher frequency(2000hz, 4000hz). Among them Severe hearing loss (71 dB to 90dB) was seen in 7 patients (6.36%),moderately severe hearing loss (61dB to 70dB) in 16 patients (14.54%) and moderate hearing loss(30dBto 60 dB) in 25 patients (22.7%). Among 47 patients who had diabetes for more than 10 years, 29 patients(61.7%) showed at least mild hearing loss. Duration of DM and sensorineural hearing loss at 2000Hz and4000Hz showed statistically significant correlation (Pearson coefficient r= 0.561 and r= 0.727respectively) at 0.01 level. In other frequencies no significant correlation was found. Coefficient ofdetermination was r2=0.31(31%) and r2=0.52(52%) respectively between duration of DM and hearing lossat 2000Hz and 4000Hz. The correlation of hearing loss in lower frequency with HbA1c did not show anystatistical significance. However HbA1c and hearing loss in higher frequency (2000 hz and 4000hz)showed statistically significant correlation (Pearson coefficient r= 0.282 and r= 0.385) respectively. Thecorrelation of hearing loss with Nerve conduction study did not show any statistical significance.Study Limitation: Longitudinal study involving larger sample size and wide geographical area wouldconfirm the above results.Conclusion: We concluded that progressive bilateral high frequency sensorineural hearing loss is acomplication of DM and probably due to involvement of inner ear structures particularly hair cells withpreservation of vestibulocochlear nerve functions. However hearing loss is unrelated to development ofperipheral neuropathy. Further study needs to be conducted to confirm the mechanism of hearing loss.

Pemmaiah K.D; Srinivas D.R

2011-01-01

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Causes of Hearing Loss in Adults  

Science.gov (United States)

... Home › Information for the Public › Hearing and Balance Causes of Hearing Loss in Adults Hearing loss in adults ... or with tinnitus (ringing in the ears). Some causes of hearing loss in adults are described below: Otosclerosis ...

20

Infants' Hearing Loss  

Directory of Open Access Journals (Sweden)

Full Text Available This is a study performed following the study between the years 1980 to 1982 to investigate risk factors and diagnostic and rehabilitative patterns in a group of newborns suffered hearing loss in a city centre. The current findings which have been attained from 1983 to 1988 manifested that just one third of the deaf newborns can be tracked by means of common auditory evaluation tests in the Neonatal Intense Care Unit (NICU). Although these newborns have been followed sooner than the infants in the Well Baby Nursery (WBN). The age for enrolling in the Parent-Infant Program for both groups is approximately 20 month. During these 8 years it has been detected that the common age for taking part in the rehabilitative programs for newborns is 1 year or more greater than that recommended by Joint Committee on infant hearing

Homa Zarin koob

1993-01-01

 
 
 
 
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Occupational Hearing Loss in Korea  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In this article, current status of noise exposure in workplaces, trend of workers with noise-induced hearing loss (NIHL), and prevalence of NIHL in workers by industry and job category in Korea were reviewed. In addition, trends of research on the audiological effects such as hearing loss from noise...

Kim, Kyoo Sang

22

Acoustic Trauma - Hearing Loss in Teenagers  

Science.gov (United States)

... Trauma - Hearing Loss in Teenagers Health Issues Listen Acoustic Trauma - Hearing Loss in Teenagers Article Body All ... temporary or permanent hearing loss. This is called acoustic trauma. How loud is 85 decibels? Surprisingly, not ...

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Hearing loss at work? Hearing loss from leisure activities?  

CERN Document Server

The nurses of the Medical Service would like invite all persons working on the CERN site to take part in a: HEARING LOSS DETECTION WEEK From 28 August to 1st September 2006 At the Infirmary, Building 57 from 9 a.m. to 4 p.m. Hearing tests - advice - information - documentation - protective equipment

2006-01-01

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Pre-enlistment hearing loss and hearing loss disability among US soldiers and marines.  

UK PubMed Central (United Kingdom)

Hearing loss is a common condition among US adults, with some evidence of increasing prevalence in young adults. Noise-induced hearing loss attributable to employment is a significant source of preventable morbidity world-wide. The US military population is largely comprised of young adult males serving in a wide variety of occupations, many in high noise-level conditions, at least episodically. To identify accession and service-related risk factors for hearing-related disability, matched case-control study of US military personnel was conducted. Individuals evaluated for hearing loss disability in the US Army and Marine Corps were frequency matched to controls without history of disability evaluation on service and enlistment year. Conditional logistic regression was used to examine the association between accession and service-related factors and hearing-related disability evaluations between October 2002 and September 2010. Individuals with medically disqualifying audiograms or hearing loss diagnoses at application for military service were 8 and 4 times more likely, respectively, to have a disability evaluation related to hearing loss, after controlling for relevant accession, demographic, and service-related factors. Conservative hearing loss thresholds on pre-enlistment audiograms, stricter hearing loss medical waiver policies or qualified baseline audiograms pre-enlistment are needed in the U.S military. Industrial corporations or labor unions may also benefit from identifying individuals with moderate hearing loss at the time of employment to ensure use of personal protective equipment and engineer controls of noise.

Gubata ME; Packnett ER; Feng X; Cowan DN; Niebuhr DW

2013-09-01

25

Noise-induced hearing loss  

Energy Technology Data Exchange (ETDEWEB)

Hearing loss affects 30 million people in the United States; of these, 21 million are over the age of 65 years. This disorder may have several causes: heredity, noise, aging, and disease. Hearing loss from noise has been recognized for centuries but was generally ignored until some time after the Industrial Revolution. Hearing loss from occupational exposure to hazardous noise was identified as a compensable disability by the United States courts in 1948 to 1959. Development of noisy jet engines and supersonic aircraft created additional claims for personal and property damage in the 1950s and 1960s. These conditions led to legislation for noise control in the form of the Occupational Safety and Health Act of 1970 and the Noise Control Act of 1972. Protection of the noise-exposed employee was also an objective of the Hearing Conservation Act of 1971. Subsequent studies have confirmed the benefits of periodic hearing tests for workers exposed to hazardous noise and of otologic evaluation as part of the hearing conservation process. Research studies in laboratory animals, using scanning electron microscopical techniques, have demonstrated that damage to the inner ear and organ of hearing can occur even though subjective (conditioned) response to sound stimuli remains unaffected. Some investigators have employed an epidemiologic approach to identify risk factors and to develop profiles to susceptibility to noise-induced hearing loss. The need for joint involvement of workers and employers in the reduction and control of occupational noise hazards is evident. 19 references.

Catlin, F.I.

1986-03-01

26

[Cervicogenic hearing loss  

UK PubMed Central (United Kingdom)

Existing investigations of cervical hearing disorders have been carried out predominantly in patients in whom those with vertebrobasilar insufficiencies (VBI) could not be distinguished from patients suffering from functional deficit of the upper cervical spine. Since two different syndromes exist, no statement can be made about cervical hearing disorders. That deafness can occur in VBI is uncontested. In contrast, there remains a dispute whether a "vertebragenic hearing disorder" exists. This latter disorder is believed accompanied by tinnitus, a feeling of ear pressure, otalgia and deafness as symptoms of a functional deficit of the upper cervical spine. In reviewing the medical findings of 259 patients with well-defined functional deficits of the upper cervical spine and symptoms of cervical vertigo, subjective hearing disorders occurred in 15%. Audiometric threshold shifts of 5-25 dB, most often in lower frequencies, were observed in 40%. Additionally, results of click-evoked otoacoustic emissions (OAE) were negative in spite of approximately normal hearing. Findings in 62 patients suffering from vertebragenic hearing disorders are reported before and after chiropractic management. Results indicate that these hearing disorders are reversible, as demonstrated by audiometry and OAE. The therapy of choice is chiropractic manipulation of the upper cervical spine. The commoness of vertebragenic hearing disorders emphasizes their clinical and forensic importance.

Hülse M

1994-10-01

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[Cervicogenic hearing loss].  

Science.gov (United States)

Existing investigations of cervical hearing disorders have been carried out predominantly in patients in whom those with vertebrobasilar insufficiencies (VBI) could not be distinguished from patients suffering from functional deficit of the upper cervical spine. Since two different syndromes exist, no statement can be made about cervical hearing disorders. That deafness can occur in VBI is uncontested. In contrast, there remains a dispute whether a "vertebragenic hearing disorder" exists. This latter disorder is believed accompanied by tinnitus, a feeling of ear pressure, otalgia and deafness as symptoms of a functional deficit of the upper cervical spine. In reviewing the medical findings of 259 patients with well-defined functional deficits of the upper cervical spine and symptoms of cervical vertigo, subjective hearing disorders occurred in 15%. Audiometric threshold shifts of 5-25 dB, most often in lower frequencies, were observed in 40%. Additionally, results of click-evoked otoacoustic emissions (OAE) were negative in spite of approximately normal hearing. Findings in 62 patients suffering from vertebragenic hearing disorders are reported before and after chiropractic management. Results indicate that these hearing disorders are reversible, as demonstrated by audiometry and OAE. The therapy of choice is chiropractic manipulation of the upper cervical spine. The commoness of vertebragenic hearing disorders emphasizes their clinical and forensic importance. PMID:8002367

Hülse, M

1994-10-01

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Prevalence of occupational noise induced hearing loss amongst traffic police personnel  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Traffic branch personnel of Pune traffic police were screened for presence of noise induced hearing loss. A very significant number (81.2%) showed sensorineural hearing loss. The various factors responsible for noise induced hearing loss are discussed.

Singh, V K; Mehta, A K

29

Noise-induced hearing loss and hearing aids requirement  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Subjective disturbances, due to hearing loss, are auditory disability and handicap which can be evaluated with a questionnaire. The present study refers to a population of industrial workers affected by noise-induced hearing loss. Aim of the study is to identify the minimal level of hearing loss ove...

Giordano, C; Garzaro, M; Nadalin, J; Pecorari, G; Boggero, R; Argentero, P; Albera, R

30

Risk factors for hearing loss in elderly  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To identify risk factors related to sensorineural hearing loss in elderly. Methods: The sample consisted of 60 selected elderly, divided into two groups: the Case Group, composed by 30 individuals, 21 females and 9 males, aged at least 60 years, presenting sensorineural hearing loss, and the Control Group, composed by 30 individuals matched on gender and age, with normal hearing. The patients were submitted to audiological anamnesis and tonal audiometry. The hearing impairment was defined according to average threshold greater than 35dBNA, in the frequencies of 1,000; 2,000 and 4,000 Hz, in the best ear. Results: Statistically significant odds ratios were: a) to audiological history: noise exposure and family history of deafness; b) to situations involving hearing difficulty: television, church, telephone, silent environment, spatial location of sound, difficulty with voices and noisy environment; c) to otologic history: tinnitus, otorrhea and nausea; and d) to medical history: visual problems, smoke, alcohol, thyroid problems and kidney disease. Conclusion: The findings of this study highlighted, for sensorineural hearing loss, risk factors related to audiologic, otologic and medical history, and to situations involving hearing difficulty.

Kelly Vasconcelos Chaves Martins; Marília Fontenele e Silva Câmara

2012-01-01

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Hearing loss in British Army musicians.  

UK PubMed Central (United Kingdom)

BACKGROUND: Military musicians increasingly fulfil front line roles. Existing literature suggests that musicians are at greater risk of hearing loss than the general population. It is important to ascertain whether these findings apply to military musicians if they are to be placed in operational acoustically hazardous environments. AIMS: To compare hearing loss between groups of British Army musicians and with their administrative (non-musician) counterparts. METHODS: Routine health surveillance audiometric data for a group of military musicians were compared with military administrative staff during the first 8-12 years of their careers. Structured interviews were used to identify those meeting the study inclusion criteria (8 year minimum service, no significant, relevant medical history, no previous extraordinary loud noise exposure, service within study employment group throughout military career), and to clarify the instrument played. RESULTS: Eighty-four musicians and 44 administrators participated. Using the Health & Safety Executive's (HSE's) age- and gender-correcting system, 12 (14%) musicians and 9 (20%) non-musicians had a deterioration in hearing. The overall odds ratio for developing hearing loss in musicians was 0.65 (95% CI 0.25-1.68). Compared with woodwind instrumentalists, the odds ratio for hearing loss in brass instrumentalists was 2.00 (95% CI 0.85-3.44) and for percussionists 1.83 (95% CI 0.77-2.90). CONCLUSIONS: The findings suggest that military musicians are at no greater risk of hearing loss than their administrative counterparts after 8-12 years in service. This may represent a healthy-worker effect. There is no statistically significant differential risk of hearing loss between different instrumental groups.

Patil ML; Sadhra S; Taylor C; Folkes SE

2013-06-01

32

Enlarged Vestibular Aqueducts and Childhood Hearing Loss  

Science.gov (United States)

... Enlarged Vestibular Aqueducts and Childhood Hearing Loss Enlarged Vestibular Aqueducts and Childhood Hearing Loss On this page: ... Where can I find additional information? What are vestibular aqueducts? Diagram of the inner ear. View larger ...

33

Causes of Hearing Loss in Children  

Science.gov (United States)

Causes of Hearing Loss in Children Otitis Media (ear Infections) | Congenital Causes | Acquired Causes Finding Help | References Otitis ... media. In fact it is the most common cause of hearing loss in young children. How common is ...

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Sensorineural hear-loss in patients with rheumatoid arthritis  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this study was to evaluate the rate and type of the hearing loss in patients with rheumatoid arthritis (RA); and to analyze whether these hearing loss rates were different from control group or not.Materials and methods: The study included 50 RA patients and 34 healthy control subjects. All two groups underwent, pure tone audiometric test between 250-8.000 Hz frequencies; stapes reflex test and otoacoustic emissions.Results: The mean ages were 36, 88 ± 8, 81 years in RA cases and 35, 58 ± 8, 19 years in control group. The mean disease duration was 4.72 (range 2-21) years in patients with RA. Hearing loss was detected in 10 (20%) of the RA patients and 3 (8.8%) of the control group. The difference between the groups was not statistically significant in terms of hearing loss (p=0,139). The sensorineural hearing loss was the most commonly detected hearing loss type. The distribution of this type of hearing loss was 14% in RA and 8.8% in control group. Hearing loss was present in 6 (85.7%) of the seven RA patients whose duration of the disease was more than 10 years.Conclusion: There was not found significant difference between RA and control group with respect to hearing loss. In RA cases, the degree of hearing loss was increasing with the duration of the diseases.

Mehtap Bozkurt; Ramazan Gün; Ali Gür; Demet Uçar; Kemal Nas

2011-01-01

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Radiation Therapy and Hearing Loss  

International Nuclear Information System (INIS)

A review of literature on the development of sensorineural hearing loss after high-dose radiation therapy for head-and-neck tumors and stereotactic radiosurgery or fractionated stereotactic radiotherapy for the treatment of vestibular schwannoma is presented. Because of the small volume of the cochlea a dose-volume analysis is not feasible. Instead, the current literature on the effect of the mean dose received by the cochlea and other treatment- and patient-related factors on outcome are evaluated. Based on the data, a specific threshold dose to cochlea for sensorineural hearing loss cannot be determined; therefore, dose-prescription limits are suggested. A standard for evaluating radiation therapy-associated ototoxicity as well as a detailed approach for scoring toxicity is presented.

2010-03-01

36

Methadone induced sensorineural hearing loss.  

UK PubMed Central (United Kingdom)

Background. Sudden sensorineural hearing loss (SSHL) caused by opiate abuse or overuse has been well documented in the medical literature. Most documented case reports have involved either heroin or hydrocodone/acetaminophen. Recently, case reposts of methadone induced SSHL have been published. Case Report. We present the case of a 31-year-old man who developed SSHL after a methadone overdose induced stupor. He was subsequently restarted on methadone at his regular dose. On follow-up audiometry exams, he displayed persistent moderately severe sensorineural hearing loss bilaterally. Discussion. This case is notable because unlike all but one previously reported case, the patient-who was restated on methadone-did not make a complete recovery. Conclusion. Methadone overuse in rare cases causes SSHL.

Saifan C; Glass D; Barakat I; El-Sayegh S

2013-01-01

37

Methadone induced sensorineural hearing loss.  

Science.gov (United States)

Background. Sudden sensorineural hearing loss (SSHL) caused by opiate abuse or overuse has been well documented in the medical literature. Most documented case reports have involved either heroin or hydrocodone/acetaminophen. Recently, case reposts of methadone induced SSHL have been published. Case Report. We present the case of a 31-year-old man who developed SSHL after a methadone overdose induced stupor. He was subsequently restarted on methadone at his regular dose. On follow-up audiometry exams, he displayed persistent moderately severe sensorineural hearing loss bilaterally. Discussion. This case is notable because unlike all but one previously reported case, the patient-who was restated on methadone-did not make a complete recovery. Conclusion. Methadone overuse in rare cases causes SSHL. PMID:23983704

Saifan, Chadi; Glass, Daniel; Barakat, Iskandar; El-Sayegh, Suzanne

2013-07-29

38

Drill-generated sensorineural hearing loss following mastoid surgery.  

UK PubMed Central (United Kingdom)

Drilling during mastoid surgery may result in temporary noise-induced hearing loss. This has practical implications for both the patient and surgeon. In a prospective study of 40 patients, audiometric testing was done both preoperatively and postoperatively to try to detect any significant hearing loss in the immediate postoperative period. The data were analyzed using the Student's paired t test. No statistically significant difference was found. A sensorineural hearing loss soon after mastoid surgery is not due to the noise generated by the drill. In the event of any hearing loss during this period, other causes should be sought.

Urquhart AC; McIntosh WA; Bodenstein NP

1992-06-01

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Pilot study of cognition in children with unilateral hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The objective of this study was to obtain preliminary data on the cognitive function of children with unilateral hearing loss in order to identify, quantify, and interpret differences in cognitive and language functions between children with unilateral hearing loss and with normal hearing. METHODS: Fourteen children ages 9-14 years old (7 with severe-to-profound sensorineural unilateral hearing loss and 7 sibling controls with normal hearing) were administered five tests that assessed cognitive functions of working memory, processing speed, attention, and phonological processing. RESULTS: Mean composite scores for phonological processing were significantly lower for the group with unilateral hearing loss than for controls on one composite and four subtests. The unilateral hearing loss group trended toward worse performance on one additional composite and on two additional phonological processing subtests. The unilateral hearing loss group also performed worse than the control group on the complex letter span task. Analysis examining performance on the two levels of task difficulty revealed a significant main effect of task difficulty and an interaction between task difficulty and group. CONCLUSIONS: Cognitive function and phonological processing test results suggest two related deficits associated with unilateral hearing loss: (1) reduced accuracy and efficiency associated with phonological processing, and (2) impaired executive control function when engaged in maintaining verbal information in the face of processing incoming, irrelevant verbal information. These results provide a possible explanation for the educational difficulties experienced by children with unilateral hearing loss.

Ead B; Hale S; Dealwis D; Lieu JE

2013-09-01

40

Association between hearing loss and depressive symptoms in elderly  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Hearing loss causes difficulties in speech understanding, which leads away from the family and social environment. This isolation may be associated with depressive disorders. Type of study: clinical prospective. Objective: To determine the association between hearing loss and depression in a group of non-institutionalized elderly. Method: The sample consisted of individuals aged over 60 years, undergoing complete audiological evaluation and screening for depressive symptoms with the Geriatric Depression Scale (GDS). Results: We evaluated 54 elderly, 26 (48.1%) were female and 28 (51.9%) males. It was found that 39 (72.2%) had hearing thresholds change, and 17 (31.5%) with mild hearing loss and 22 (40.7%) with moderate hearing loss. Were evident signs of depression in 25 elderly (46.3%), and 22 (40.7%) had hearing loss. Data analysis showed an association between hearing loss and depression (p = 0.016). Although not significant (p = 0.18), the association between the degree of hearing loss was positive in relation to the severity of the signs of depression. Conclusion: In elderly people surveyed, there was a strong association between hearing loss and signs of depression and tendency to be an association between the degree of hearing loss and the severity of the signs of depression.

Teixeira, Adriane Ribeiro; Gonçalves, Andréa Krüger; Freitas, Cíntia de La Rocha; Soldera, Cristina Loureiro Chaves; Bós, Angelo José Gonçalves; Santos, Ana Maria Pujol Vieira dos; Dornelles, Sílvia

2010-01-01

 
 
 
 
41

Effects of Hearing Loss on Development  

Science.gov (United States)

Effects of Hearing Loss on Development It is well recognized that hearing is critical to speech and ... may have an impact on vocational choices. Specific Effects Vocabulary Vocabulary develops more slowly in children who ...

42

Noise Induced Hearing Loss and Auditory Localization.  

Science.gov (United States)

Many studies have been conducted on the ability of normal hearing listeners to judge the locations of various sounds. A few researchers have explored the effects of noiseinduced hearing loss on auditory localization acuity (Noble, Byrne and Lepage, 1994; ...

M. A. Ericson A. B. Staley

2003-01-01

43

Hearing loss and use of hearing protection among career firefighters in the United States.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To determine the prevalence and characteristics of noise-induced hearing loss (NIHL) and the use of hearing protection devices (HPDs) among career firefighters. METHODS: A Web-based survey and a standard audiometric test were performed with 425 firefighters from three states in the United States. RESULTS: More than 40% showed hearing loss in the noise-sensitive frequencies (4 and 6 kHz). The left ear showed significantly poorer hearing than the right ear. Firefighters having longer years of work in fire services demonstrated significantly worse hearing. Reported use of HPDs was 34% of the time that was needed. Firefighters who used HPDs less were significantly more likely to have hearing loss. CONCLUSIONS: This study demonstrated a considerable NIHL problem and low use of HPDs in firefighters. More comprehensive hearing conservation programs should be implemented to reduce NIHL for firefighters.

Hong O; Chin DL; Samo DG

2013-08-01

44

Sensorineural hearing loss in neurobrucellosis.  

Science.gov (United States)

A case of neurobrucellosis presenting to the otologist with sensorineural hearing loss (SNHL) as the predominant clinical feature is reported. The diagnostic features and treatment options are discussed and the need for prolonged combination treatment to prevent relapse and further deterioration of hearing stressed. SNHL in neurobrucellosis has hitherto been reported principally in neurology literature as something of an incidental finding and so escapes the attention of otologists. It is hoped that this report will alert otologists in areas where brucellosis is endemic to the need to include tests for brucellosis in the routine diagnostic screening for SNHL. Practitioners in other locations should also consider this possibility when dealing with patients who have visited or lived in endemic regions. PMID:8288975

Thomas, R; Kameswaran, M; Murugan, V; Okafor, B C

1993-11-01

45

Sensorineural hearing loss in neurobrucellosis.  

UK PubMed Central (United Kingdom)

A case of neurobrucellosis presenting to the otologist with sensorineural hearing loss (SNHL) as the predominant clinical feature is reported. The diagnostic features and treatment options are discussed and the need for prolonged combination treatment to prevent relapse and further deterioration of hearing stressed. SNHL in neurobrucellosis has hitherto been reported principally in neurology literature as something of an incidental finding and so escapes the attention of otologists. It is hoped that this report will alert otologists in areas where brucellosis is endemic to the need to include tests for brucellosis in the routine diagnostic screening for SNHL. Practitioners in other locations should also consider this possibility when dealing with patients who have visited or lived in endemic regions.

Thomas R; Kameswaran M; Murugan V; Okafor BC

1993-11-01

46

Advances in genetic diagnostics for hereditary hearing loss.  

Science.gov (United States)

Abstract Hereditary hearing loss affects a significant proportion of the hearing impaired, with genetic mutations estimated to be responsible for its etiology in over 50% of this population. The methods for molecular diagnostics are changing as a result of the transition from linkage analysis to next generation sequencing to identify the genes responsible for hearing loss in affected families. In this review, we summarize the attitudes of the hearing impaired towards genetic testing, the latest techniques for identifying mutations, and provide a comprehensive list of the mutations found in the Israeli Jewish hearing-impaired population. PMID:24006325

Idan, Natali; Brownstein, Zippora; Shivatzki, Shaked; Avraham, Karen B

2013-09-01

47

Advances in genetic diagnostics for hereditary hearing loss.  

UK PubMed Central (United Kingdom)

Abstract Hereditary hearing loss affects a significant proportion of the hearing impaired, with genetic mutations estimated to be responsible for its etiology in over 50% of this population. The methods for molecular diagnostics are changing as a result of the transition from linkage analysis to next generation sequencing to identify the genes responsible for hearing loss in affected families. In this review, we summarize the attitudes of the hearing impaired towards genetic testing, the latest techniques for identifying mutations, and provide a comprehensive list of the mutations found in the Israeli Jewish hearing-impaired population.

Idan N; Brownstein Z; Shivatzki S; Avraham KB

2013-09-01

48

Ages of hearing loss diagnosis and cochlear implantation in hearing impaired children  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Aim: Early diagnosis of hearing loss lead to early intervention and improvement of developmental skills of children with hearing loss. The present study aimed to determine the mean age of hearing loss diagnosis and cochlear implantation (CI) in hearing impaired children and to compare the age of performing cochlear implantation in children who were identified by newborn hearing screening with those who were not.Methods: This cross-sectional study was conducted on 96 children with severe to profound sensorineural hearing loss who received cochlear implantation in Amir-e-Alam cochlear implantation center between the years 2008 and 2010. For data gathering, we assessed subjects' medical archives, interviewed with their parents and took medical history including demographic information, birth history and hearing loss history.Results: Mean age of hearing loss suspicion, diagnosis, hearing aids administration, Initiation of rehabilitation program, performing cochlear implantation and mean age when cochlear implantation was utilized were 6.73 (SD=5.79), 9.35 (SD=5.79), 13.41 (SD=6.10), 16 (SD=6.36), 41.25 (SD=11.12), and 42.15 (SD=11.00) months, respectively. There was statistically significant difference between them (p<0.05). 43.8% of hearing impaired children had been identified by newborn hearing screening. There was statistically significant difference between cochlear implantation operation age of children who were identified by newborn hearing screening with those who were not (p<0.0001).Conclusion: In spite of notable reduction in the age of hearing loss diagnosis and intervention during recent years, compared to international indices it is still tardy. Conducting newborn hearing screening can significantly reduce these ages.

Zahra Jeddi; Zahra Jafari; Masoud Motasaddi Zarandy

2012-01-01

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Effects of common agricultural tasks on measures of hearing loss.  

UK PubMed Central (United Kingdom)

BACKGROUND: Among agricultural populations, hearing loss caused by excessive noise exposure is common. However, examinations of associations between exposure to agricultural tasks and hearing loss are limited. METHODS: Audiometry and lifetime exposure to 11 agricultural tasks were analyzed among 1,568 participants. Gender stratified multivariable linear regression was used to estimate associations between exposure duration and three hearing loss metrics. RESULTS: Among men, significant associations were observed between hearing loss and hunting or target shooting, all-terrain vehicle (ATV) or motorcycle riding, chain saw use, electric or pneumatic tool use, living on a farm, and all agricultural tasks combined. When all significant exposure metrics were included in a single model, associations remained for hunting or target shooting, electric or pneumatic tool use and living on a farm. Significant associations were sparse among women, and in all cases paradoxical. CONCLUSIONS: Despite imprecise estimation of noise exposure, specific agricultural tasks were associated with hearing loss.

Humann MJ; Sanderson WT; Gerr F; Kelly KM; Merchant JA

2012-10-01

50

Murine malaria is associated with significant hearing impairment  

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Full Text Available Abstract Background Plasmodium falciparum malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria. This prospective study aims to evaluate whether malaria influences hearing in mice. Methods Twenty mice were included in a standardized murine cerebral malaria model. Auditory evoked brainstem responses were assessed before infection and at the peak of the illness. Results A significant hearing impairment could be demonstrated in mice with malaria, especially the cerebral form. The control group did not show any alterations. No therapy was used. Conclusion This suggests that malaria itself leads to a hearing impairment in mice.

Schmutzhard Joachim; Kositz Christian H; Lackner Peter; Dietmann Anelia; Fischer Marlene; Glueckert Rudolf; Reindl Markus; Stephan Kurt; Riechelmann Herbert; Schrott-Fischer Annelies; Schmutzhard Erich

2010-01-01

51

¿Hipoacusia súbita?/ Sudden Hearing Loss?  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Se presenta un caso de paciente mujer sin antecedentes mórbidos que consulta a nuestro servicio por síntomas sugerentes de hipoacusia súbita. La evaluación audiométrica y prueba calórica era compatible con una parálisis cocleovestibular y dado que no presentaba contraindicaciones, se decide iniciar tratamiento con corticoides y antiviral oral. La evolución inicial fue favorable sin embargo al control del mes presentó un nuevo deterioro audiométrico. Esto motivó (more) mayor estudio con el cual se pudo llegara un diagnóstico etiológico. Este caso es presentado para recordar que hay otras patologías que pueden simular una hipoacusia súbita idiopática, lo cual no se debe olvidaren el manejo de estos pacientes. Abstract in english Clinical case of female patient without morbid background who consults due to sudden hearing loss symptoms. The audiometric and caloric tests were compatible with a cochleo vestibular paralysis and because there were no contraindications, oral steroids and antiviral, treatment was indicated. Although the initial response was favorable, at the first month check up an audiometric deterioration was found. This led to further study achieving an etiological diagnosis. This cas (more) e is presented to remind that there are other pathologies that can simulate an idiopathic sudden hearing loss, which should not be forgotten in the management of these patients.

Cornejo Sch, Santiago; García M, Raimundo; San Martín P, José

2010-04-01

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Hearing loss in Muckle-Wells syndrome.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Muckle-Wells syndrome (MWS) is an inherited autoinflammatory disease characterized by fevers, rashes, arthralgia, conjunctivitis, and sensorineural hearing loss. In MWS, NLRP3 gene mutations are associated with excessive interleukin-1 release. The aims of this study were to determine the otologic characteristics of MWS, define trajectories of hearing loss, and explore the association with distinct NLRP3 genotypes. METHODS: A prospective observational cohort study of children and adults diagnosed as having MWS was conducted at a single center. NLRP3 gene mutations were determined. Patients underwent standardized clinical, laboratory, and otologic assessments, including pure tone audiometry, vestibular organ testing, and tinnitus evaluation. Trajectories of hearing loss were defined for each genotype. The genotype-specific risk of progression of hearing loss was determined. RESULTS: A total of 33 patients ages 3-75 years who were members of 5 families with 4 different NLRP3 gene mutations were included. The majority of patients (67%) experienced bilateral sensorineural hearing loss. Even in cases of profound hearing loss vestibular reactivity remained normal. Fourteen adult patients reported nondebilitating tinnitus. Overall, hearing impairment progressed with age. Patients with the T348M mutation were at highest risk of rapid progression of sensorineural hearing loss. CONCLUSION: Patients with MWS are at risk of developing progressive sensorineural hearing loss without vestibular involvement. Hearing impairment starts at high frequencies and can subsequently progress to profound hearing loss. Progression is age dependent. Patients with different NLRP3 mutations had distinctly different trajectories of hearing loss, suggesting a mutation-specific risk that should be considered when making treatment decisions.

Kuemmerle-Deschner JB; Koitschev A; Ummenhofer K; Hansmann S; Plontke SK; Koitschev C; Koetter I; Angermair E; Benseler SM

2013-03-01

53

Hearing loss in skeletal dysplasia patients.  

UK PubMed Central (United Kingdom)

A hearing screening program was performed to determine the prevalence of hearing loss and abnormal tympanometry in individuals with short-stature skeletal dysplasias attending a national meeting. Behavioral audiometry, otoacoustic emission testing, and tympanometry were used to assess hearing. Failed hearing screen was defined as hearing ? 35 dB at one or more frequencies or by "fail" on otoacoustic emissions. One hundred ten of 112 subjects completed the screening. 58 (51.8%) were children. Seventy-three (65.2%) had achondroplasia, 34 (30.4%) had one of 11 other diagnoses, and 5(4.4%) were undiagnosed. 25.8% of children failed hearing screening in one or both ears, while 46.3% of adults failed in one or both ears. 55.1% of adults and 25.0% of children with achondroplasia failed screening. Abnormal hearing was also found in the some patients with spondyloepiphyseal dysplasia congenital (SEDC; 75%), diastrophic dysplasia (66%), and Morquio (66%). Hearing was normal in those with hypochondroplasia, pseudoachondroplasia, and microcephalic osteodysplastic primordial dwarfism. Tympanometry was abnormal in at least one ear in 53.3% of children and 38.5% of adults. Abnormal tympanometry in the absence of functioning tympanostomy tubes was associated with 9.5 greater odds of hearing loss in children and 2.8 greater odds of hearing loss in the total cohort. Only 3 (2.7%) respondents reported the use of hearing aids. Hearing loss and middle ear disease are common in both children and adults with skeletal dysplasia. Adults were more likely to fail hearing screening than children. Abnormal tympanometry is associated with hearing loss. Hearing screening with appropriate intervention is recommended for these patients.

Tunkel D; Alade Y; Kerbavaz R; Smith B; Rose-Hardison D; Hoover-Fong J

2012-07-01

54

Hearing loss in skeletal dysplasia patients.  

Science.gov (United States)

A hearing screening program was performed to determine the prevalence of hearing loss and abnormal tympanometry in individuals with short-stature skeletal dysplasias attending a national meeting. Behavioral audiometry, otoacoustic emission testing, and tympanometry were used to assess hearing. Failed hearing screen was defined as hearing ? 35 dB at one or more frequencies or by "fail" on otoacoustic emissions. One hundred ten of 112 subjects completed the screening. 58 (51.8%) were children. Seventy-three (65.2%) had achondroplasia, 34 (30.4%) had one of 11 other diagnoses, and 5(4.4%) were undiagnosed. 25.8% of children failed hearing screening in one or both ears, while 46.3% of adults failed in one or both ears. 55.1% of adults and 25.0% of children with achondroplasia failed screening. Abnormal hearing was also found in the some patients with spondyloepiphyseal dysplasia congenital (SEDC; 75%), diastrophic dysplasia (66%), and Morquio (66%). Hearing was normal in those with hypochondroplasia, pseudoachondroplasia, and microcephalic osteodysplastic primordial dwarfism. Tympanometry was abnormal in at least one ear in 53.3% of children and 38.5% of adults. Abnormal tympanometry in the absence of functioning tympanostomy tubes was associated with 9.5 greater odds of hearing loss in children and 2.8 greater odds of hearing loss in the total cohort. Only 3 (2.7%) respondents reported the use of hearing aids. Hearing loss and middle ear disease are common in both children and adults with skeletal dysplasia. Adults were more likely to fail hearing screening than children. Abnormal tympanometry is associated with hearing loss. Hearing screening with appropriate intervention is recommended for these patients. PMID:22628261

Tunkel, David; Alade, Yewande; Kerbavaz, Richard; Smith, Beth; Rose-Hardison, Danielle; Hoover-Fong, Julie

2012-05-24

55

Relation between Glaucoma and Sensorineural Hearing Loss  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Glaucoma is one of the leading causes of blindness throughout the world. Some studies have suggested a relationship between glaucoma and sensorineural hearing loss, while others have found no evidence of an association. We performed a study to determine whether there is a significant difference in hearing of patients with glaucoma and a match control population. Methods: In this cross-sectional study, from February, 2005 till April, 2006, 44 patients with glaucoma were studied. The age range was between 15 to 60 years. After taking a complete medical history, those suffering from presbycusis, history of exposure to ototoxic drugs and substances and history of ear surgery were excluded from the study. All of the patients were cases of open-angle glaucoma, and were surveyed separately for normal-pressure glaucoma. Then complete audiometric tests (PTA, SDS, SRT, Impedance) were conducted for all of them, and the results compared with a control group. Results: There was no statistically significant difference between the case group and control group in PTA, SDS, and SRT, except for Normal Tension Glaucoma (NTG). There wasn't any statistically significant difference between two groups with respect to age, gender, and history of diseases. In the NTG group, significant difference was seen only in high frequencies. Conclusion: As mentioned, there was a statistically significant difference between NTG group and control group. It is therefore recommended to conduct complete audiometric tests and histopathologic examinations in this group for early detection of hearing loss and application of rehabilitative measures.

MR Vahidi; J Ayatollahi; Gh Karimi; A Mollasadeghi

2008-01-01

56

Addressing adult hearing loss in primary care.  

UK PubMed Central (United Kingdom)

AIMS: To (a) determine the extent to which primary care providers screen adults for environmental or occupational hearing loss during the primary care visit and (b) determine what techniques are used to screen for hearing loss in the adult primary care patient. BACKGROUND: Although the prevalence of hearing loss is high, the frequency and techniques of screening for hearing loss among primary care providers are unknown. According to the United States Preventative Task Force, hearing screening promotes early detection, adequate treatment, and improved quality of life. DESIGN: It is a retrospective audit. METHODS: Thirty client records were randomly selected from two clinics in 2009 for this retrospective patient record audit. RESULTS/FINDINGS: Physical assessment of the structure of the auditory system was completed in all cases selected. Hearing acuity in all cases was determined by patient self-assessment, as indicated on patient-completed history forms; there was no documentation of objective assessment of auditory function. CONCLUSION: Given the low correlation between perceived and measured hearing ability, assessment of hearing ability by patient report alone may result in failure to detect hearing loss. Research into the nature and extent of barriers to hearing assessment in primary care needs to be explored, and criteria for screening of adults in the primary care setting should be established.

McCullagh MC; Frank K

2013-04-01

57

Cleidocranial dysplasia with hearing loss.  

UK PubMed Central (United Kingdom)

Cleidocranial dysplasia is an inherited skeletal anomaly that affects primarily the skull, clavicle, and dentition, which can occur spontaneously, but most are inherited in autosomal dominant mode. The skull findings are brachycephaly, delayed or failed closure of the fontanelles, presence of open skull sutures and multiple wormian bones with pronounced frontal bossing. The syndrome is notable for aplasia or hypoplasia of the clavicles. The neck appears long and narrow and the shoulders markedly droop. Oral manifestations exhibit a hypoplastic maxilla with high-arched palate. Crowding of teeth is produced by retention of deciduous teeth, delayed eruption of permanent teeth, and the presence of a large number of unerupted supernumerary teeth. We report a case of CCD in a 12-year-old girl who presented with an unaesthetic facial appearance, unerupted permanent dentition with hearing loss.

Candamourty R; Venkatachalam S; Yuvaraj V; Kumar GS

2013-01-01

58

Hearing Loss Protection Using Vitamins  

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Full Text Available Background and Aim: Machine-made life along with the industrialization of the societies has caused the human to deal with a kind of stressful environment made up of aching sound and vibration sources. Noisiness has been one of the biggest problems of today’s world that the people are in danger of its painful effects. Auditory disorder is the most common reason for Adult Acquired Hearing Loss. As a result, protection against auditory disorders seems to be necessary. Method: In accordance with the importance of this idea, a number of researches in the field of nutrition which resulted in finding the relation between NIHL and vitamins have been carried out. Through the assessment the fact that vitamins can have both preventative and curing influence on NIHL has been evident. Furthermore, it has been discovered that the deficiency of above-mentioned instances can in a way increase the sensitivity of auditory system to noise. Result: There are various mechanisms for NIHL, and each vitamin in a way can go against the destructive affection of it (NIHL). For instance, vitamins A,C and E along with Magnesium can wipe out the free radicals produced by noise exposure. Making use of Antioxidants combinations like vitamin E can prevent auditory cells from death and Noise Induced Hearing Loss from coming about.Conclusion: Vitamin A deficiency increases the sensitivity of auditory system to noise and as a result increases the susceptibility to NIHL. Vitamin C by preventing DNA Oxidation and Lipid Peroxidation in Cochlea has preventive and therapeutic effects on NIHL. Vitamin B12, B6 Deficiency and Folic Acid by damaging Stereo Vascular increase the vulnerability to NIHl. The mechanism and how vitamins affect each of above-mentioned instances will be covered within the article in details.

Mojtaba Khazaee; Farnaz Fathollahzadeh; Sara Bahaghighat

2013-01-01

59

Unilateral sudden hearing loss due to otosyphilis  

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The differential diagnosis of sudden hearing loss is very extensive. However, in most patients, no underlying pathology will be found and the patient is consequently diagnosed with idiopathic sudden hearing loss. Nevertheless, it is important that one stays alert in everyday routine practice to less...

Maaike J. de Goffau; Jan C. Doelman; Jeroen B. van Rijswijk

60

Localization in speech mixtures by listeners with hearing loss.  

UK PubMed Central (United Kingdom)

The ability of listeners with bilateral sensorineural hearing loss to localize a speech source in a multitalker mixture was measured. Five simultaneous words spoken by different talkers were presented over loudspeakers in a small room, and listeners localized one target word. Errors were significantly larger in this group compared to a control group with normal hearing. Localization of the target presented alone was not different between groups. The results suggest that hearing loss does not impair spatial hearing per se, but degrades the spatial representation of multiple simultaneous sounds.

Best V; Carlile S; Kopco N; van Schaik A

2011-05-01

 
 
 
 
61

Localization in speech mixtures by listeners with hearing loss.  

Science.gov (United States)

The ability of listeners with bilateral sensorineural hearing loss to localize a speech source in a multitalker mixture was measured. Five simultaneous words spoken by different talkers were presented over loudspeakers in a small room, and listeners localized one target word. Errors were significantly larger in this group compared to a control group with normal hearing. Localization of the target presented alone was not different between groups. The results suggest that hearing loss does not impair spatial hearing per se, but degrades the spatial representation of multiple simultaneous sounds. PMID:21568377

Best, Virginia; Carlile, Simon; Kopco, Norbert; van Schaik, André

2011-05-01

62

Evidence-Based Practices Are Not Reformulated Best Practices: A Response to Martindale's "Children with Significant Hearing Loss: Learning to Listen, Talk, and Read--Evidence-Based Best Practices"  

Science.gov (United States)

"Communication Disorders Quarterly's" special series on evidence-based practices and, specifically, Martindale's article on evidence-based practices in learning to listen, talk, and read among children with significant hearing loss appear to confuse best practices with evidence-based practices and, perhaps more serious, offer little evidence for…

Schirmer, Barbara R.; Williams, Cheri

2008-01-01

63

Tinnitus and patterns of hearing loss.  

UK PubMed Central (United Kingdom)

Tinnitus is strongly linked with the presence of damaged hearing. However, it is not known why tinnitus afflicts only some, and not all, hearing-impaired listeners. One possibility is that tinnitus patients have specific inner ear damage that triggers tinnitus. In this study, differences in cochlear function inferred from psychophysical measures were measured between hearing-impaired listeners with tinnitus and hearing-impaired listeners without tinnitus. Despite having similar average hearing loss, tinnitus patients were observed to have better frequency selectivity and compression than those without tinnitus. The results suggest that the presence of subjective tinnitus may not be strongly associated to outer hair cell impairment, at least where hearing impairment is evident. The results also show a different average pattern of hearing impairment amongst the tinnitus patients, consistent with the suggestion that inner hair cell dysfunction with subsequent reduced auditory innervation is a possible trigger of tinnitus.

Tan CM; Lecluyse W; McFerran D; Meddis R

2013-04-01

64

Tinnitus and patterns of hearing loss.  

Science.gov (United States)

Tinnitus is strongly linked with the presence of damaged hearing. However, it is not known why tinnitus afflicts only some, and not all, hearing-impaired listeners. One possibility is that tinnitus patients have specific inner ear damage that triggers tinnitus. In this study, differences in cochlear function inferred from psychophysical measures were measured between hearing-impaired listeners with tinnitus and hearing-impaired listeners without tinnitus. Despite having similar average hearing loss, tinnitus patients were observed to have better frequency selectivity and compression than those without tinnitus. The results suggest that the presence of subjective tinnitus may not be strongly associated to outer hair cell impairment, at least where hearing impairment is evident. The results also show a different average pattern of hearing impairment amongst the tinnitus patients, consistent with the suggestion that inner hair cell dysfunction with subsequent reduced auditory innervation is a possible trigger of tinnitus. PMID:23328862

Tan, Christine M; Lecluyse, Wendy; McFerran, Don; Meddis, Ray

2013-01-18

65

Cochlear implantation in adults with asymmetric hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Bilateral severe to profound sensorineural hearing loss is a standard criterion for cochlear implantation. Increasingly, patients are implanted in one ear and continue to use a hearing aid in the nonimplanted ear to improve abilities such as sound localization and speech understanding in noise. Patients with severe to profound hearing loss in one ear and a more moderate hearing loss in the other ear (i.e., asymmetric hearing) are not typically considered candidates for cochlear implantation. Amplification in the poorer ear is often unsuccessful because of limited benefit, restricting the patient to unilateral listening from the better ear alone. The purpose of this study was to determine whether patients with asymmetric hearing loss could benefit from cochlear implantation in the poorer ear with continued use of a hearing aid in the better ear. DESIGN: Ten adults with asymmetric hearing between ears participated. In the poorer ear, all participants met cochlear implant candidacy guidelines; seven had postlingual onset, and three had pre/perilingual onset of severe to profound hearing loss. All had open-set speech recognition in the better-hearing ear. Assessment measures included word and sentence recognition in quiet, sentence recognition in fixed noise (four-talker babble) and in diffuse restaurant noise using an adaptive procedure, localization of word stimuli, and a hearing handicap scale. Participants were evaluated preimplant with hearing aids and postimplant with the implant alone, the hearing aid alone in the better ear, and bimodally (the implant and hearing aid in combination). Postlingual participants were evaluated at 6 mo postimplant, and pre/perilingual participants were evaluated at 6 and 12 mo postimplant. Data analysis compared the following results: (1) the poorer-hearing ear preimplant (with hearing aid) and postimplant (with cochlear implant); (2) the device(s) used for everyday listening pre- and postimplant; and (3) the hearing aid-alone and bimodal listening conditions postimplant. RESULTS: The postlingual participants showed significant improvements in speech recognition after 6 mo cochlear implant use in the poorer ear. Five postlingual participants had a bimodal advantage over the hearing aid-alone condition on at least one test measure. On average, the postlingual participants had significantly improved localization with bimodal input compared with the hearing aid-alone. Only one pre/perilingual participant had open-set speech recognition with the cochlear implant. This participant had better hearing than the other two pre/perilingual participants in both the poorer and better ear. Localization abilities were not significantly different between the bimodal and hearing aid-alone conditions for the pre/perilingual participants. Mean hearing handicap ratings improved postimplant for all participants indicating perceived benefit in everyday life with the addition of the cochlear implant. CONCLUSIONS: Patients with asymmetric hearing loss who are not typical cochlear implant candidates can benefit from using a cochlear implant in the poorer ear with continued use of a hearing aid in the better ear. For this group of 10, the 7 postlingually deafened participants showed greater benefits with the cochlear implant than the pre/perilingual participants; however, further study is needed to determine maximum benefit for those with early onset of hearing loss.

Firszt JB; Holden LK; Reeder RM; Cowdrey L; King S

2012-07-01

66

The significance of a hypoplastic bony canal for the cochlear nerve in patients with sensorineural hearing loss: CT and MRI findings  

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The purpose of this study is to evaluate the significance of the hypoplastic canal for the cochlear nerve in patients with sensorineural hearing loss (SNHL) and the relationship between the hypoplastic bony canal and aplasia or hypoplasia of the cochlear nerve. A retrospective review of high resolution temporal CT(HRCT) and MRI findings was conducted. The narrow bony canal of the cochlear nerve and the relative size of the internal auditory canal were correlated with the cochlear nerve deficiency on MRI. The comparative size of the component nerves (facial, cochlear, superior vestibular, inferior vestibular nerve), and the relative size of the internal auditory canal and the bony canal of the cochlear nerve were measured. The clinical history and the results of the clinical examination were reviewed for each patient. High resolution MRI showed aplasia of the common vestibulocochlear nerve in one patient and a deficiency of the cochlear nerve in 9 patients. These abnormalities occurred in association with a prominent narrowing of the canal for the cochlear nerve and a stenosis of the internal auditory canal, which was observed on temporal bone CT in 9 patients with congenital SNHL. Three patients had normal IAC, despite the presence of a hypoplastic cochlear nerve on the side on which they had SNHL. In one patient, the narrowing of the canal for the cochlear nerve and internal auditory canal were not found to be associated with acquired SNHL. The hypoplastic bony canal for the cochlear nerve might be more highly indicative of congenital cochlear nerve deficiency than that of the narrow internal auditory canal, and the position of the crista falciformis should also be carefully.

Choi, Yoon Jung; Park, Sang Yoo; Kim, Myung Soon; Sung, Ki Jun [College of Medicine, Yonsei Univ., Wonju (Korea, Republic of)

2004-04-01

67

The significance of a hypoplastic bony canal for the cochlear nerve in patients with sensorineural hearing loss: CT and MRI findings  

International Nuclear Information System (INIS)

The purpose of this study is to evaluate the significance of the hypoplastic canal for the cochlear nerve in patients with sensorineural hearing loss (SNHL) and the relationship between the hypoplastic bony canal and aplasia or hypoplasia of the cochlear nerve. A retrospective review of high resolution temporal CT(HRCT) and MRI findings was conducted. The narrow bony canal of the cochlear nerve and the relative size of the internal auditory canal were correlated with the cochlear nerve deficiency on MRI. The comparative size of the component nerves (facial, cochlear, superior vestibular, inferior vestibular nerve), and the relative size of the internal auditory canal and the bony canal of the cochlear nerve were measured. The clinical history and the results of the clinical examination were reviewed for each patient. High resolution MRI showed aplasia of the common vestibulocochlear nerve in one patient and a deficiency of the cochlear nerve in 9 patients. These abnormalities occurred in association with a prominent narrowing of the canal for the cochlear nerve and a stenosis of the internal auditory canal, which was observed on temporal bone CT in 9 patients with congenital SNHL. Three patients had normal IAC, despite the presence of a hypoplastic cochlear nerve on the side on which they had SNHL. In one patient, the narrowing of the canal for the cochlear nerve and internal auditory canal were not found to be associated with acquired SNHL. The hypoplastic bony canal for the cochlear nerve might be more highly indicative of congenital cochlear nerve deficiency than that of the narrow internal auditory canal, and the position of the crista falciformis should also be carefully.

2004-01-01

68

SELF REPORTED HEARING LOSS AMONG ELDERLY MALAYSIANS  

Directory of Open Access Journals (Sweden)

Full Text Available A cross-sectional study was conducted on patients attending a primary care facility to determine the prevalence of self reported hearing loss using a single question, “Do you have hearing loss?” Pure tone audiometry was performed to compare the accuracy of the self report. A total of 111 patients were recruited. The prevalence of self reported hearing loss using a single question and pure tone audiometry was 24.3% and 36.9% respectively. By using pure tone audiometry at a cut-off-level of 25 dBHL (decibels Hearing level), the single question yielded a sensitivity of 41.4% and specificity of 85.0%. The single question performed better at 40 dBHL pure tone audiometry with sensitivity of 55.0% and specificity of 82.0%. In conclusion, the prevalence of hearing loss in elderly was high and the single question self reported hearing loss performed satisfactorily with moderate hearing loss.

ROSDINA AK; LEELAVATHI M; ZAITUN A; LEE VKM; AZIMAH MN; MAJMIN SH; MOHD KA

2010-01-01

69

Cisplatin and cranial irradiation-related hearing loss in children.  

UK PubMed Central (United Kingdom)

Background: High doses of cisplatin and cranial radiotherapy (CRT) have been reported to cause irreversible hearing loss. The objective of this study was to examine the influence of cranial irradiation on cisplatin-associated ototoxicity in children with pediatric malignancies.Methods: Serial audiograms were obtained for 33 children, age <16 years, treated with cisplatin-based chemotherapy (90-120 mg/m(2) per cycle) with or without CRT. Eligible patients included those with normal baseline audiometric evaluations and without significant exposure to other ototoxic drugs. We defined significant hearing loss as a hearing threshold ?30 dB at 2,000-8,000 Hz frequencies.Results: The median age of our study population was 4.9 years (range 6 weeks to 16 years), and the male to female ratio was 0.8:1. The study population consisted of 15 Caucasians, 17 African-Americans, and 1 Hispanic. Fourteen patients had brain tumors, and 19 had other solid tumors. Thirteen patients were exposed to CRT, and 20 were not. Bilateral hearing loss was observed in 24/33 (73%) patients, with severe/profound (?70 dB) impairment in 10/33 (30%) of all patients. Young age (<5 years), CRT, and brain tumors were independent prognostic factors predicting hearing loss.Conclusion: The study demonstrated a high incidence of hearing loss in children treated with cisplatin and CRT. Consequently, we recommend monitoring these children for the early detection of hearing loss.

Warrier R; Chauhan A; Davluri M; Tedesco SL; Nadell J; Craver R

2012-01-01

70

Leupeptin reduces impulse noise induced hearing loss  

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Abstract Background Exposure to continuous and impulse noise can induce a hearing loss. Leupeptin is an inhibitor of the calpains, a family of calcium-activated proteases which promote cell death. The objective of this study is to assess whether Leupeptin could reduce the hearing lo...

Gavriel Haim; Shulman Abraham; Stracher Alfred; Sohmer Haim

71

Hearing loss in Western Samoan children  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In an effort to help determine the current status and needs of hearing impaired children in Western Samoa, the Commonwealth Society for the Deaf sent a team of three professionals to this Pacific island nation in 1991. Initial information on known children with severe and profound hearing loss was g...

Mcpherson, B

72

Use of a hearing loss grading system and an owner-based hearing questionnaire to assess hearing loss in pet dogs with chronic otitis externa or otitis media.  

UK PubMed Central (United Kingdom)

BACKGROUND: Hearing loss is important when assessing the suitability of dogs with otitis externa/media for medical or surgical therapy. HYPOTHESIS/OBJECTIVES: To assess an owner-completed questionnaire as an indicator of hearing loss and a canine hearing loss scoring system in chronic canine otitis. ANIMALS: One hundred hospital population dogs referred for chronic otitis investigation. METHODS: Owners completed a questionnaire to assess their dog's response to common household noises. The presence of otitis externa or media was determined and brainstem auditory-evoked response measurements were performed on each dog. The minimal hearing threshold (MHT) in decibels normal hearing level (dB NHL) was recorded and categorized according to the human World Health Organization grading system into five grades from 0 to 4 with cut-off values of ?25 dB NHL, 26-40 dB NHL, 41-60 dB NHL, 60-80 dB NHL and ?81 dB NHL. RESULTS: The questionnaire correctly determined normal hearing in grade 0 cases, but did not reliably detect unilateral or grade 1 bilateral hearing loss. For dogs with bilateral hearing loss ? grade 2, questionnaire sensitivity was 83% [24 of 29, 95% confidence interval, (CI) 64-94%] and specificity was 94% (67 of 71, 95% CI 86-98%). Higher grades of hearing loss were significantly associated with the presence of otitis media (P < 0.01). CONCLUSIONS AND CLINICAL IMPORTANCE: The questionnaire may be a useful in-practice screening tool in chronic canine otitis for moderate to severe bilateral hearing deficits (MHT ?41 dB NHL). The hearing loss grading system may help clinicians make therapeutic decisions. Chronic otitis media may be associated with higher grades of hearing loss.

Mason CL; Paterson S; Cripps PJ

2013-07-01

73

Gd enhanced MRI in sensorineural hearing loss  

International Nuclear Information System (INIS)

The enhanced MRI hearing findings of the inner ear in 124 patients with sensorineural hearing loss were evaluated. MR images were obtained before and after the intravenous administration of gadolinium (0.1 mmol/kg). In three out of seventy-nine patients with unilateral healing loss, cochlear and/or the vestibular enhancement was noted on the symptomatic side. The positive cases included those with Ramsay-Hunt syndrome, mumps and so-called sudden deafness. Forty-five patients with bilateral hearing loss showed no enhancement within the inner ear. Although positive gadolinium enhancement of the inner ear may detect inflammatory lesions due to a viral infection, its incidence in sensorineural hearing loss, including cases of sudden deafness. seems to be extremely rare. (author).

1996-01-01

74

Preventing noise-induced hearing loss in firefighters.  

UK PubMed Central (United Kingdom)

NIOSH recommends the use of quieter equipment, better work practices, and hearing protection devices and implementation of effective hearing loss prevention programs to prevent noise-induced hearing loss in firefighters. [Workplace Health Saf 2013;61(9):420.].

Chalupka S

2013-09-01

75

Subjective Fatigue in Children with Hearing Loss: Some Preliminary Findings.  

UK PubMed Central (United Kingdom)

PURPOSE: This study examined the effect of hearing loss on subjective reports of fatigue in school-age children using a standardized measure. METHODS: As part of a larger ongoing study, subjective ratings of fatigue were obtained using the PedsQL Multidimensional Fatigue Scale. This standardized scale provides a measure of general fatigue, sleep/rest fatigue, cognitive fatigue and an overall composite measure of fatigue. To date, data from 10 children with hearing loss (CHL) and 10 age-matched children with normal hearing (CNH) have been analyzed. RESULTS: These preliminary results show subjective fatigue is increased in school-age children with hearing loss (Cohen's d = .78-1.90). Additionally, the impact of hearing loss on fatigue in school-age children appears pervasive across multiple domains (general, sleep/rest and cognitive fatigue). CONCLUSIONS: School-age CHL reported they are significantly more fatigued than CNH. These preliminary data are important given the negative academic and psychosocial consequences associated with fatigue. Further research is needed to determine the underlying mechanisms responsible for this increased fatigue in school-age children with hearing loss, and to identify factors that may modulate (e.g., degree of loss) and mediate (e.g., hearing aid or cochlear implant use) its impact.

Hornsby BW; Werfel K; Camarata S; Bess FH

2013-07-01

76

Sensorineural Hearing Loss in Chronic Otitis Media  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Conductive hearing loss due to chronic otitis media (COM) can be treated by surgery. COM, however, may be associated with functional damage to the inner ear. Sensorineural hearing loss (SNHL) due to COM has been found to be significant by some authors, whereas it has been considered negligible by others. The present study aimed to answer the question; Does COM cause SNHL ? Methods: 120 patients with unilateral COM admitted for tympano-mastoidectomy were selected for this observational case-control study. Air conduction threshold (ACT) and bone conduction threshold (BCT) averages were calculated at the speech frequencies (500, 1000, 2000Hz) and 4 KHz, in affected (case ear) and non affected (control ear) and then entered in the questionnaire along with intraoperative findings. Multiple statistical tests were used to clarify the relationships between SNHL and COM. Results: COM was seen to be associated with SNHL. The Threshold shift was more accentuated at 4 KHz in older patients. SNHL at 4 KHz seemed to be higher than that at the speech frequencies. There was a significant positive relationship between the elevated BCT and duration of COM. The relationship between elevated BCT and cholesteatoma was also significant. Conclusion: The inner ear is vulnerable to COM. The proximity of the sensory cells to the potential source of harm (inflamed middle ear) may mean higher exposure, as reflected by the fact that sensory cells processing high frequencies are more seriously damaged. SNHL in affected ear is strongly dependant on duration of disease.

A Mirvakili; MH Baradaranfar; A Hasani; R Jafari

2008-01-01

77

Reading skills of hearing and moderately severe hearing loss children in ordinary schools  

Directory of Open Access Journals (Sweden)

Full Text Available   Background and Aim: Hearing impairment in critical period of speech and language development is caused defects in oral and written language. The aim of this study is to use a test for comparing the reading skills of elementary fifth grade hearing and moderately severe hearing loss students in public schools. Materials and Methods: In this cross sectional study, 10 hearing impaired children selected from the total number of fifth grade moderately severe hearing loss students' community (public schools) based on the inclusion criteria and compared with 10 hearing children that were matched according to grade, as a control group. In order to gather the data, reading and writing tests for school students was used. Data analysis was done through SPSS-16. Results: The findings indicated that hearing impaired children on auditory discrimination skills (P=0.001), word auditory memory (P=0.034) sentence auditory memory (P<0.001), phonological blending (P=0.034), phonological segmentation (P=0.012) and text reading comprehension (P=0.044) were significantly weaker than the control group, but they had similar function in other skills. Conclusion: Children with hearing impairment have the same function in tasks based on visual processing to normal children, whereas, in tasks based on auditory and phonological processing are weaker than them. Keywords: Reading skills, Hearing loss children, Public schools

Mohammad Rezaei; Vahid Rashedi; Gohar Lotfi; Farzad Weisi

2013-01-01

78

Irreversible atorvastatin-associated hearing loss.  

UK PubMed Central (United Kingdom)

Drug-associated ototoxicity is a potentially irreversible adverse event. Among the several 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) available in the United States, only atorvastatin is associated with tinnitus, but none are associated with any forms of hearing loss. A search of the published literature (1950-August 2011) revealed no published case reports of ototoxicity associated with statins. To our knowledge, we describe the first case of progressive, irreversible hearing loss in a 32-year-old man 18 months after starting atorvastatin therapy. He began taking atorvastatin 20 mg every evening for treatment of hypercholesterolemia. Six months later, he complained of occasional episodes of tinnitus, which resolved spontaneously. An audiogram was obtained and was normal. By 18 months, the tinnitus became continuous. Another audiogram revealed bilateral "cookie-bite" middle-frequency hearing loss. Atorvastatin was immediately discontinued, and the patient was fitted with hearing aids. Four years after drug discontinuation, his hearing loss had neither progressed nor regressed. Use of the Naranjo adverse drug reaction probability scale indicated a possible (score of 2) temporal and causal relationship between the patient's hearing loss and atorvastatin. Causes of "cookie-bite" hearing loss include chronic exposure to loud noises, presbycusis, genetic predisposition, and drugs. The manufacturer of atorvastatin has received three unpublished cases of deafness, but claims that causal relationships were not established. Despite these claims by the manufacturer, based on this case report, we recommend that clinicians and patients be aware of the risk of atorvastatin-associated tinnitus and permanent hearing loss. Further research is needed to better understand the mechanism and frequency of this adverse event.

Liu M; Alafris A; Longo AJ; Cohen H

2012-02-01

79

Hearing loss in veterans and the need for hearing loss prevention programs.  

UK PubMed Central (United Kingdom)

Currently, there are more than 445,000 veterans receiving compensation for hearing loss associated with military service, and 395,000 receiving compensation for service-related tinnitus. In addition to compensation payments, service-related hearing disorders cost the US Department of Veterans Affairs in terms of provision of hearing aids, hearing aid-related services, and clinical services at its 220 facilities nationwide. It is imperative that hearing conservation among military personnel and veterans be addressed. In this paper, we describe the rationale for and the development of a multimedia Hearing Loss Prevention Program aimed at preventing the progression of hearing loss among veterans associated with social, recreational, and nonmilitary occupational noise exposure. The program was developed based on the principles outlined in the Health Belief Model of Rosenstock (1966) and the Health Promotion Model of Pender et al. (2002).

Saunders GH; Griest SE

2009-01-01

80

Living with Hearing and Vision Loss Due to Usher Syndrome  

Medline Plus

Full Text Available ... Vision Loss Due to Usher Syndrome Living with Hearing and Vision Loss Due to Usher Syndrome Note: ... Vision Loss Video (Quicktime) Transcript of Living with Hearing and Vision Loss Due to Usher Syndrome Video ...

 
 
 
 
81

Pathologic erythrocyte deformability in patients with sudden sensorineural hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate if viscoelastic properties of blood influence suffering sudden sensorineural hearing loss and the capacity to respond after a specific therapy. PATIENTS AND METHODS: A longitudinal prospective study included 85 ears bearing sudden deafness. In them, the mean hearing loss compared to the healthy ear and the recovery ratio were measured at the onset and 6 months after a treatment with corticoids and piracetam. In addition, tinnitus or vestibular symptoms, whole blood filterability (WBF) and erythrocyte deformability -by means of the erythrocyte rigidity index (ERI)- were determined and noted at the beginning and the end of the study. RESULTS: Mean hearing loss was 30.3±19.7% at the onset, and 25.8±39% at the end. Forty-one ears showed a recovery of more than 75%. In these (48% of the entire study group), an increase in WBF and a decrease in ERI were observed (P<.001). Ears without tinnitus or vestibular crisis recovered more hearing at 6 months and showed a significant improvement in WBF and ERI, not detected among patients with these clinical findings. There were good correlations between mean hearing loss at onset and WBF, and between recovery and ERI at 6 months, but without statistical significance. Patients with arterial hypertension, cardiopathy and hypercholesterolemia were the most frequently detected, while hypertension and hyperuricaemia showed a better hearing recovery ratio. CONCLUSIONS: The blood viscosity parameters WBF and ERI offer useful information about the risk of suffering sudden deafness and the capacity to recover hearing with reactive therapies.

García-Callejo FJ; Marco-Algarra J; Pla-Gil I; Monzó-Gandía R; Juantegui-Azpilicueta M; Martínez-Beneyto P

2012-07-01

82

Hearing conservation program for marching band members: a risk for noise-induced hearing loss?  

UK PubMed Central (United Kingdom)

PURPOSE: To examine the risk for noise-induced hearing loss (NIHL) in university marching band members and to provide an overview of a hearing conservation program for a marching band. METHOD: Sound levels during band rehearsals were recorded and audiometric hearing thresholds and transient otoacoustic emission were measured over a 3-year period. Musician's earplugs and information about hearing loss were provided to the students. The hearing thresholds of other college students were tested as a partial control. RESULTS: There were no significant differences in hearing thresholds between the two groups. During initial testing, more marching band members showed apparent high-frequency notches than control students. Follow-up hearing tests in a subsequent year for the marching band members showed that almost all notches disappeared. Persistent standard threshold shift (STS) across tests was not observed in the band members. CONCLUSION: Band members showed no evidence of STS or persistent notched audiograms. Because accepted procedures for measuring hearing showed a lack of precision in reliably detecting early NIHL in marching band members, it is recommended that signs of NIHL be sought in repeated measurements compared to baseline audiograms rather than in a single measure (a single notch). A hearing conservation program for this population is still recommended because of lengthy rehearsal times with high sound-level exposure during rehearsals.

Jin SH; Nelson PB; Schlauch RS; Carney E

2013-06-01

83

Viagra deafness--sensorineural hearing loss and phosphodiesterase-5 inhibitors.  

UK PubMed Central (United Kingdom)

BACKGROUND: Viagra and PDE-5 inhibitors use has mushroomed since its launch over a decade ago. A growing body of evidence indicates significant morbidity associated with the side effect profile of this class of drug. Hearing loss associated with PDE-5 inhibitor use has recently been reported, but few studies have evaluated the causal link. AIM: To review and scrutinise the current literature on the subject and propose possible physiologic mechanisms and to investigate the global reporting of this side effect. METHODS AND MATERIALS: Pharmacovigilance agencies around North America, Europe, and Australasia were contacted requesting reports of hearing loss associated with PDE-5 inhibitors. Reports were scrutinised to exclude those where others causes of hearing loss existed. RESULTS: Forty-seven cases of sensorineural hearing loss with a temporal association with PDE-5 inhibitor ingestion were obtained from both published literature and pharmacovigilance agencies. Cases had a mean age 56.6 years, male-to-female ratio of 7:1. Eighty-eight percent of reports were unilateral with an even left/right distribution. Hearing loss occurred within 24 hours of ingestion of PDE-5 inhibitor in 66.7% (n = 18) of cases. Sildenafil accounted for over 50% of cases. CONCLUSION: There is increasing evidence that PDE-5 inhibitors may induce sensorineural hearing loss via plausible physiological mechanisms. There needs to be more awareness of this disabling side effect among healthcare professionals responsible for prescribing this drug.

Khan AS; Sheikh Z; Khan S; Dwivedi R; Benjamin E

2011-05-01

84

Experiences of adult patients hearing loss postlingually with Cochlear Implant  

Directory of Open Access Journals (Sweden)

Full Text Available Hearing loss is a significant public health problem. The incidence is difficult to establish because of the lack of data in people under age three, but is estimated about 1 per thousand for severe and profound hearing loss.A cochlear implant (CI) is a device that converts sounds into electrical energy that triggers a sensation of hearing. The IC is indicated in patients with severe bilateral sensorineural hearing loss with null or poor benefit use of hearing aids.The general objective of this project is to understand the experiences of adult patients with severe-profound sensorineural hearing loss with IC postlingually throughout the implementation process.A personal vision of those implemented will allow us to learn how to face the possibility to hear and interact with their environment, applying this information to improve health care provided to them and identifying those areas where such assistance should be improved. Also allow us to compare the initial expectations and have been achieved, creating realistic expectations for future candidates.For its development we have designed a qualitative study, based on the principles and procedures of grounded theory, semistructured interviews, participant observation and discussion groups.The data will be analyzed using the software Nudist ViVo 9.

Antonio Gigante León; Teresa María Lizcano Tejado; Blanca Fernández-Lasquetty Blanc; Nieves Martínez Jiménez; Maria Luisa Villamayor Losada; Rosa-Ana García Laguna

2013-01-01

85

Hearing handicap in adults with unilateral deafness and bilateral hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To assess the perception of hearing handicap in adult patients with unilateral sudden sensorineural hearing loss (SNHL) compared with those with bilateral SNHL or unilateral congenital SNHL. STUDY DESIGN: Retrospective chart review. SETTING: Multicenter department of otolaryngology referrals. PATIENTS: Seventy-one subjects in the unilateral severe-profound (>70 dB) sudden SNHL group (Group 1), 17 subjects in the unilateral prelingual or congenital SNHL group (Group 2), and 121 subjects in the bilateral SNHL group (Group 3). INTERVENTIONS: Questionnaire. MAIN OUTCOME MEASURES: Hearing Handicap Inventory for Adults (HHIA) and visual analogue scale (VAS) measurements of hearing handicap. RESULTS: Average levels of hearing loss were 92 dB in Group 1, 109 dB in Group 2, and 67 dB in Group 3. The relative percentage scores of HHIA and VAS compared with Group 3 were 72.6% and 81.0% in Group 1 and 25.4% and 50.3% in Group 2, respectively. A mild correlation between the HHIA subscale or VAS scores and degree of hearing loss could be found in Group 3. No significant correlation was found between the HHIA subscale or VAS scores and duration of hearing loss in Group 1 or Group 3. Higher scores were obtained in male subjects than in female subjects. Patients in Group 1 who were troubled by tinnitus scored significantly higher in the HHIA. In multiple logistic regression analysis, presence of tinnitus, older age, higher average hearing loss level, and group (bilateral SNHL>unilateral sudden SNHL>unilateral precongenital SNHL) revealed a significant positive association with high score (>42) of HHIA (odds ratio, 3.171, 1.021, 1.031, and 6.690, respectively). CONCLUSION: The results of HHIA and VAS suggest that not only patients with bilateral SNHL but also those with unilateral sudden SNHL, particularly those who have tinnitus, experience a hearing handicap.

Iwasaki S; Sano H; Nishio S; Takumi Y; Okamoto M; Usami S; Ogawa K

2013-06-01

86

Acquired Hearing Loss and Psychiatric Symptoms  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: World Health Organization (WHO) defines hearing loss as an impairment in perception, attention and organisation as well as in speaking, In this study, on the base of biopsychosocial theory, we aimed to determine both psychiatric symptoms of the patients who have acquired (but ideopathic) hearing impairment/loss, and also, if there was, an association between this physical illness and psychiatric symptoms. Methods: The groups of patients with mild, moderate and severe hearing impairment and a healthy control group were enrolled in the study. Each group contained 30 persons. A sociodemographic questionnaire, the Symptom Check List 90-Revised Form (SCL-90-R) and the Non-Patients Form of Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (SCID-NP) were used. Results: The psychopathology that have been found in our study was 35.6% in patients group versus 20% in controls. 30-50% of patients with hearing loss reported both social and psychological problems. According to SCL-90-R, in the patients’ groups who had especially moderate and severe hearing loss were more paranoid and depressive; they had more eating and sleeping difficulties; also they complained more from musical hallucinations (25%) and their scores of positive symptoms and of additional scales in SCL-90-R were higher than the controls (p< 0.001). In SCID-NP, especially the hallucination, the paranoia and the depression scores were higher in patients with hearing loss. Conclusion: The reasons for psychiatric symptoms in the patients with hearing impairment or loss are multiethiological and it is known that disability is the major ethiological factor. The results of our study showed us that the psychiatry and the other medical disciplines should always work together. (Archives of Neuropsychiatry 2009; 46: 149-56)

Aytül Gürsu HAR?R?; Gülcan ÖZER; Mehmet Emin CEYLAN

2009-01-01

87

[Mastoid surgery for secretory otitis media with mixed hearing loss].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To analyze the therapeutic effect of mastoid surgery for secretory otitis media with mixed hearing loss. METHODS: A retrospective analysis was conducted of the data from 26 cases (43 ears) of secretory otitis media with bone conduction hearing loss collected from 2001 to 2008. Thirty-two ears were treated with mastoid surgery and myringotomy with insertion of ventilation tubes. All the patients received medications after the operation. RESULTS: All the patients showed obvious improvement after mastoid surgery. The average pure tone of air conduction hearing threshold was about 25 dB after the surgery, with the average pure tone of bone conduction hearing threshold of about 15 dB. The patients were followed up for 1-2 years during which no significant change in hearing was recorded, and no middle ear effusion in the tympanic cavity was found after removal of the ventilation tubes. CONCLUSION: Persistent secretory otitis media can be associated with mixed hearing loss, and mastoid surgery can significantly enhance the hearing level to produce positive therapeutic effects.

Feng XH; Long XB; Wang J; Chen YT; Guo XQ

2010-07-01

88

Predicting hearing loss in facioscapulohumeral muscular dystrophy.  

UK PubMed Central (United Kingdom)

Facioscapulohumeral muscular dystrophy (FSHD) has an estimated prevalence of 4-7 per 100,000 population, making it the third most common type of muscular dystrophy. The classic form of FSHD is characterized by weakness that is slowly progressive and often asymmetric in the face, scapulae, upper arms, lower legs, and abdomen. The age at onset of symptoms varies from infancy to middle age, and life expectancy is normal or almost normal. Aside from muscle weakness, other manifestations include chronic pain, hearing loss, retinal telangiectasias and exudation (Coats syndrome) that can progress to retinal detachment and vision loss, cardiac arrhythmias, cognitive impairment, and epilepsy.(1) There seems to be an increased prevalence of hearing loss in FSHD compared with the general population. Hearing loss has been described particularly in patients with infantile-onset FSHD but also in typical cases.(2) In severe infantile-onset cases, the hearing loss can be profound, and if not detected may lead to delayed language development and even the false perception of cognitive impairment. Consensus-based recommendations suggest routine hearing testing in infants and preschool-age children diagnosed with FSHD.(3.)

Darras BT; Tawil R

2013-09-01

89

BERA in children with hearing loss and delayed speech.  

UK PubMed Central (United Kingdom)

OBJECTIVES: The brainstem evoked response audiometry (BERA) is an objective neurophysiological method for the evaluation of the hearing threshold and diagnosing retrocochlear lesions. The aim of the study was to investigate the hearing level in children with suspected hearing loss or pathological speech development. PATIENTS AND METHODS: The BERA diagnostic procedure was applied in 184 children ranging from 1 to 12 years of age at Ahmadi Hospital in Kuwait. RESULTS: We found profound hearing loss (deafness) in 13 children, severe hearing loss in 8 children, moderate hearing loss in 34 children, mild hearing loss in 34 children, and normal hearing level in 95 children. Out of the children suspected for hearing loss, 42% actually had some level (mild-moderate) of hearing loss. Out of the children with delayed speech, 63% had some level (mild-profound) of hearing loss which actually caused the delay in speech development; 37% had normal hearing, but inadequate verbal communication affected their language acquisition and speech development. CONCLUSIONS: These results illustrate the necessity to test children hearing even with the slightest suspicion by the parent or doctor of hearing loss. The results warrant the establishment of a hearing screening test of newborns in Kuwait to provide hearing aid to children with hearing loss.

Al-Kandari JM; Alshuaib WB; Joe M

2006-01-01

90

Correlating the site of tympanic membrane perforation with Hearing loss  

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Full Text Available Abstract Background It is recognized that the size of tympanic membrane(TM) perforation is proportional to the magnitude of hearing loss, however, there is no clear consensus on the effect of the location (site) of the perforation on the hearing loss. Hence the study is set to investigate the relationship between the location of perforation on TM and hearing loss. Methods A cross-sectional prospective study of consecutive adult patients with perforated TM conducted in the ENT clinic of University College Hospital Ibadan between January 1st 2005 and July 31st 2006. Instruments used for data collection/processing include questionnaires, video and micro-otoscopy, Pure tone audiometer, image J and SPSS packages. Results Sixty-two patients (22-males, 40-females), aged 16–75 years (mean = 35.4 +/- 4) with 77 perforated ear drums were studied and 15(24.2%) had bilateral TM perforations, 21 (33.9%) right unilateral and 26(41.9%) left unilateral. The locations of the TM perforations were 60(77.9%) central, 6(9.6%) antero-inferior, 4(5.2%) postero-inferior, 4(5.2%) antero-superior and 3(3.9%) postero-superior respectively with sizes ranging from 1.51%–89.05%, and corresponding hearing levels 30 dB – 80 dB (59% conductive and 41% mixed). Fifty-nine percent had pure conductive hearing loss and the rest mixed. Hearing losses (dBHL) increased with the size of perforations (P = 0.01, r = 0.05). Correlation of location of perforations with magnitude of hearing loss in acute TM perorations was (P = 0.244, r = 0.273) and for chronic perforations (p = 0.047 & r = 0.31). Conclusion The location of perforation on the tympanic membrane (TM) has no effect on the magnitude of hearing loss in acute TM perforations while it is significant in chronic ones.

Ibekwe Titus S; Nwaorgu Onyekwere G; Ijaduola Taiwo G

2009-01-01

91

Hearing loss in Angolan children with sickle-cell disease.  

UK PubMed Central (United Kingdom)

BACKGROUND: Hearing loss and pneumococcal infections occur in children with sickle-cell disease (SCD). We assessed the prevalence of hearing loss and otological findings, especially otitis media, among children with SCD in Luanda, Angola. METHODS: We performed otorhinolaryngological examination, tympanometry and, at ages over 5 years, pure-tone audiometry, in 61 outpatients of the SCD clinic and 61 healthy controls in the Paediatric Hospital of Luanda. RESULTS: Bilateral hearing loss exceeding 25 dB occurred in nine (36%; median age 7.8 years) SCD children versus three (11%; P = 0.047) control children. The hearing loss in the SCD group was predominantly mild (26-40 dB), involved low- and speech-range frequencies, and was sex independent. Acute otitis media occurred in two (3%) children with SCD versus four (6%; P = 0.68) control children, chronic otitis in zero versus two (3%; P = 0.50), and middle-ear effusion in one versus one (2%; P > 0.99). We found no significant differences in the otological profiles of the study groups. CONCLUSIONS: In sub-Saharan Africa, hearing screening of SCD children is a must at preschool age. The actual prevalence of otitis media and its role in the cause of hearing loss in children with SCD remain subjects for further research.

Taipale A; Pelkonen T; Bernardino L; Peltola H; Pitkäranta A

2012-12-01

92

Noise-induced hearing loss in French police officers.  

UK PubMed Central (United Kingdom)

BACKGROUND: There is a lack of data about police officers' hearing thresholds and the risk of noise-induced hearing loss (NIHL) associated with this occupation. In France, 129,000 national police officers, 96,000 state police force members and 16000 municipal police officers may be affected by occupational noise exposure. AIMS: To evaluate the association between police employment and NIHL. METHODS: We undertook a cross-sectional study using review of medical records. Audiometric and otological data and information on potential confounders were extracted from medical records. Global hearing loss and selective 4000 Hz hearing loss were analysed. RESULTS: Of total, 1692 subjects (887 policemen and 805 civil servants) participated in the study. After adjusting for potential cofounders, police officers were 1.4 times more likely to have a selective 4000 Hz hearing loss than civil servants (95% CI 1.1-1.9). This difference was greater between motorcycle police officers and civil servants (OR = 3; 95% CI 1.4-6.3). CONCLUSIONS: These data suggest that occupational noise exposure in police work, particularly in motorcycle police officers, may induce hearing loss. Noise sources need to be more accurately defined to confirm high-level noise exposures, to better define significant sources of noise and to identify effective solutions.

Lesage FX; Jovenin N; Deschamps F; Vincent S

2009-10-01

93

Hearing loss in insulin-dependent diabetes mellitus.  

UK PubMed Central (United Kingdom)

The purpose of this study was to examine the relationship between diabetes mellitus and hearing loss which is still controversial. Pure tone audiometry was performed in 75 patients with insulin-dependent diabetes mellitus, aged between 14 and 60 years (45 males and 30 females; average age 45.3 years), and in 40 randomly selected sex- and age-matched non-diabetic control subjects, using an Interacoustics Clinical Computer Audiometer Model AC5. The mean duration of diabetes in the study group was 15 +/- 7 years. Complications such as retinopathy, nephropathy, and neuropathy had developed in 64% of the diabetics. Statistical analyses showed that the hearing of the diabetic patients was significantly worse than control subjects. Complications were found to have a significant effect on sensorineural hearing loss in diabetics. The influence of duration of diabetes was noticed on hearing threshold at mid and high frequencies, especially after the first decade of the disease.

Celik O; Yalçin S; Celebi H; Oztürk A

1996-01-01

94

Hearing loss in insulin-dependent diabetes mellitus.  

Science.gov (United States)

The purpose of this study was to examine the relationship between diabetes mellitus and hearing loss which is still controversial. Pure tone audiometry was performed in 75 patients with insulin-dependent diabetes mellitus, aged between 14 and 60 years (45 males and 30 females; average age 45.3 years), and in 40 randomly selected sex- and age-matched non-diabetic control subjects, using an Interacoustics Clinical Computer Audiometer Model AC5. The mean duration of diabetes in the study group was 15 +/- 7 years. Complications such as retinopathy, nephropathy, and neuropathy had developed in 64% of the diabetics. Statistical analyses showed that the hearing of the diabetic patients was significantly worse than control subjects. Complications were found to have a significant effect on sensorineural hearing loss in diabetics. The influence of duration of diabetes was noticed on hearing threshold at mid and high frequencies, especially after the first decade of the disease. PMID:8809334

Celik, O; Yalçin, S; Celebi, H; Oztürk, A

1996-01-01

95

Non-organic hearing loss in childhood.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The present study aimed to investigate the etiology, symptoms, diagnosis and prognosis of pediatric patients with non-organic hearing loss (NOHL), and to heighten awareness of this disorder among physicians. METHODS: Between January 2000 and July 2009, we retrospectively reviewed the medical records of 47 pediatric patients (aged 6-18 years of age) diagnosed with NOHL. The diagnosis was made when there were audiometric discrepancies between the subjective and objective hearing thresholds of the patient in the absence of any organic disease. RESULTS: Eighteen patients presented with unilateral hearing loss, and 29 showed bilateral hearing loss. Five patients received steroid treatment before the correct diagnosis was made, and six had secretory otitis media and underwent a tympanostomy tube placement. CONCLUSION: If physicians are unaware of the possibility of NOHL; they may misdiagnose children with idiopathic sudden sensorineural hearing loss and administer high-dose steroid treatments or exploratory tympanotomies. Otoacoustic emissions are abolished when NOHL patients have secretory otitis media. In these cases, after tympanostomy tube placement, they should undergo objective electrophysiologic examinations to reevaluate NOHL.

Morita S; Suzuki M; Iizuka K

2010-05-01

96

Comparison of Working Memory in Hearing Loss and Normal Children  

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Full Text Available Introduction: Hearing loss children may have problems in auditory-verbal memory due to impaired auditory input, but likely they have no deficit in visual-verbal memory because of intact visual input. In this study auditory-verbal and visual-verbal memory of sever to moderate (56-70 dB) hearing loss students in special schools compared with normal group.Materials and Methods: In this descriptive cross sectional study, hearing loss and normal children compared by means of working memory subtest of "reading and writing in elementary school students test".Results: The findings indicated that hearing impaired children on sound, word and sentence auditory-verbal memory were significantly weaker than the control group, but they had similar function in sound (reverse) auditory-verbal memory skill with their. Normal and hearing impaired group have similar performance in letter and picture visual-verbal memory.Conclusion: According to the results seems hearing impairment is the cause of poor performance in auditory working memory. Also children with hearing impairment have the same function in tasks based on visual processing to normal children, whereas, in tasks based on auditory processing are weaker than them.

Mohammad Rezaei; Gohar Lotfi; Farzad Wiesi

2012-01-01

97

Classification and hearing evolution of patients with sudden sensorineural hearing loss  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english The aim of this study was to analyze clinical aspects, hearing evolution and efficacy of clinical treatment of patients with sudden sensorineural hearing loss (SSNHL). This was a prospective clinical study of 136 consecutive patients with SSNHL divided into three groups after diagnostic evaluation: patients with defined etiology (DE, N = 13, 10%), concurrent diseases (CD, N = 63, 46.04%) and idiopathic sudden sensorineural hearing loss (ISSHL, N = 60, 43.9%). Initial trea (more) tment consisted of prednisone and pentoxifylline. Clinical aspects and hearing evolution for up to 6 months were evaluated. Group CD comprised 73% of patients with metabolic decompensation in the initial evaluation and was significantly older (53.80 years) than groups DE (41.93 years) and ISSHL (39.13 years). Comparison of the mean initial and final hearing loss of the three groups revealed a significant hearing improvement for group CD (P = 0.001) and group ISSHL (P = 0.001). Group DE did not present a significant difference in thresholds. The clinical classification for SSNHL allows the identification of significant differences regarding age, initial and final hearing impairment and likelihood of response to therapy. Elevated age and presence of coexisting disease were associated with a greater initial hearing impact and poorer hearing recovery after 6 months. Patients with defined etiology presented a much more limited response to therapy. The occurrence of decompensated metabolic and cardiovascular diseases and the possibility of first manifestation of auto-immune disease and cerebello-pontine angle tumors justify an adequate protocol for investigation of SSNHL.

Penido, N.O.; Cruz, O.L.M.; Zanoni, A.; Inoue, D.P.

2009-08-01

98

Assesment of Hearing Loss in Patients with Psoriasis  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Design: Psoriasis is an autoimmune chronic inflammatory skin disease characterized by T-cell mediated hyperproliferation of keratinocytes. Sensorineural hearing loss accompanied by autoimmune diseases was first described by McCabe in 1979. Cases of hearing loss associated with various autoimmune diseases have been reported. However, the number of studies evaluating the hearing loss in patients with psoriasis is insufficient. In this study, we aimed to assess hearing loss in psoriasis patients. Material and Methods: Fifty-one psoriasis patients, who were admitted to our outpatient clinic in 2010, and 51 healthy volunteers were included in the study. All participants underwent a complete ear, nose and throat examination before audiological assessment followed by, pure-tone audiometry in a sound-isolated audiology laboratory. Statistical analysis was performed using PASW Statistics version 18.0.0. A p-value less than 0.05 was considered statistically significant. Results: The mean bone and hearing thresholds were higher for all frequencies in patients than in controls. The values reached statistical significance at all frequencies except for right ear air conduction at 1000 Hz, bone conduction at 500 and 1000 Hz, left ear air conduction at 500 Hz, and bone conduction at 500 Hz (p<0.05). We compared the Psoriasis Area and Severity Index (PASI) scores adjusted for age and disease duration and thresholds matched with frequencies and found a significant correlation between PASI score and hearing loss at medium and high frequencies. Conclusion: In psoriasis, chronic inflammation is thought to be the main pathological process destroying structure and functions of skin, nails and joints. We think that the same process may affect the cochlea in a similar way. The correlation between high PASI scores and hearing loss at medium and high frequencies may be an unexpected result of increased inflammatory mediators responsible from the disease in exacerbation periods.

Serdar Cenk Güvenç; Hakan Turan; Süleyman Y?lmaz; Mehmet Emin Yan?k; Abdullah Berada; Cihangir Alia?ao?lu

2012-01-01

99

Clinical and genetic features of hearing loss in facioscapulohumeral muscular dystrophy.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To describe the hearing loss in facioscapulohumeral muscular dystrophy (FSHD) and examine the relationship to genotype. METHODS: Medical records of all individuals with FSHD seen at the University of Iowa neuromuscular clinic between July 2006 and July 2012 (n = 59) were reviewed. Eleven had significant hearing loss and no non-FSHD cause. All available audiology records for these individuals were analyzed. The relationship between the FSHD mutation (EcoRI/BlnI fragment size) and hearing loss was evaluated using a logistic regression analysis. RESULTS: In patients with hearing loss, recalled age at onset of facial weakness ranged from birth to 5 years and shoulder weakness was 3 to 15 years. The age at diagnosis of hearing loss ranged from birth to 7 years. Only 2 were identified by newborn hearing screen. Most audiograms demonstrated a bilateral, sloping, high-frequency sensorineural hearing loss. Of the 4 patients with more than 5 years of data, 3 had progression of hearing loss. Logistic regression showed statistically significant negative association between the presence of hearing loss and EcoRI/BlnI fragment size (p = 0.0207). CONCLUSIONS: FSHD with a small EcoRI/BlnI fragment is associated with a bilateral, progressive, sloping, high-frequency hearing loss with onset in childhood. Patients with FSHD and small EcoRI/BlnI fragment sizes should have hearing screened, even if the child passed newborn hearing screening.

Lutz KL; Holte L; Kliethermes SA; Stephan C; Mathews KD

2013-09-01

100

Prevalence of unilateral hearing loss among kindergarteners aged 3-6 years in Hamadan city, 2012  

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Full Text Available Introduction: Unilateral hearing loss has devastating effects on sound localization, speech understanding in adverse listening conditions, academic achievement, behavior and learning of Hearing impaired children. Early detection and intervention with regard to the issues of unilateral hearing loss is important in young children. The main goal of this study was to determine the prevalence of unilateral hearing loss among kindergarteners aged 3-6 years in Hamadan city, 2012.Material and Methods: In this cross-sectional descriptive study, 345 subjects (185 female, 160 male) were selected through random sampling. Play Audiometry test was used to determine the hearing threshold.Results: The results indicated that from the sum of 690 ears, 30(4.3%), had unilateral hearing loss; 26 (3.8%) with conductive hearing loss, 3 (0.4%) with sensorineural hearing loss and one (0.1%) with mixed hearing loss. No significant differences were observed between paired ears, genders and different ages.Conclusion: In this study, the prevalence of unilateral hearing loss was high (4.3%), 3.8% is conductive hearing loss accruing least one during childs language learning. Given the high prevalence of unilateral hearing loss in children 3-6 years of age, and the importance of this period in speech, language and learning development, early diagnosis and intervention is essential.

Atta Heidari; Ayub Valadbeigi

2012-01-01

 
 
 
 
101

Effects of hearing aid amplification on voice F0 variability in speakers with prelingual hearing loss.  

UK PubMed Central (United Kingdom)

To investigate the audio-vocal feedback responses of (F0) to hearing amplification in severe-to-profound prelingual hearing loss (SPHL) using power spectral analysis of F0 contour of sustained vowels. Sustained phonations of vowel/a/of seventeen participants with SPHL were acquired with and without hearing-aid amplifications. The vocal intensity was visually fed back to the participants to help controlling the vocal intensity at 65-75 dBA and 85-95 dBA. The F0 contour of the phonations was extracted and submitted to spectral analysis to measure the extent of F0 fluctuations at different frequency ranges. The results showed that both high vocal intensity and hearing-aid amplification significantly improved voice F0 control by reducing the low-frequency fluctuations (low-frequency power, LFP, 0.2-3 Hz) in F0 spectrum. However, the enhanced feedback from higher vocal intensity and/or hearing amplification was not adequate to reduce the LFP to the level of a normal hearing person. Moreover, we found significant and negative correlations between LFP and supra-threshold feedback intensity (phonation intensity - hearing threshold level) for the frequencies of 500-2000 Hz. Increased vocal intensity, as well as hearing-aid amplification, improved voice F0 control by reducing the LFP of F0 spectrum, and the subtle changes in voices could be well explored using spectral analysis of F0.

Lee GS; Liu C; Lee SH

2013-08-01

102

Occupational Noise-induced Hearing Loss  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Noise-induced hearing loss (NIHL) is a well-known entity in daily practice of otolaryngology. A wide variety of NIHLs are work-related. Occupational noise is the most common cause of NIHL in adults which is up to now considered incurable and the best approach to it is to utilize maximal protection. ...

MH Azizi

103

Age-related hearing loss patterns in Fischer 344/NHsd rats with cisplatin-induced hearing loss.  

UK PubMed Central (United Kingdom)

The current study was undertaken to explore the impact of cisplatin ototoxicity at a young adult age on the development of age-related hearing loss, both in terms of age of onset and severity of the hearing loss. For the study, 21 Fischer 344/NHsd rats were tested. All rats were tested for auditory brainstem responses (ABRs) at age 7 months and then 15 of the rats were exposed to 7 mg/kg cisplatin by intra-peritoneal infusion. The other 6 rats received saline infusions to serve as controls. Seven of the cisplatin rats were euthanized after an ABR test 7 days after cisplatin exposure to assess acute damage. The other 14 rats were tested monthly until age 18 months. Cisplatin caused acute ABR threshold shift at 30 and 40 kHz, but that acute hearing loss led to less age-related hearing loss at those frequencies. Cisplatin exposure led to a primarily additive interaction with age-related hearing loss at 20 kHz, with some exacerbation of hearing loss at age 16-18 months, along with a larger lesion of missing outer hair cells in the corresponding region of the cochlea. ABR P1 amplitude input-output functions were not significantly affected by the cisplatin exposure when controlling for threshold shift. Results indicate that cisplatin ototoxicity and age-related hearing loss interact antagonistically in the cochlear region damaged by cisplatin, and primarily show an additive interaction in the frequencies lower than the focus of the cisplatin damage.

Bielefeld EC

2013-09-01

104

'Ecstasy' enhances noise-induced hearing loss.  

Science.gov (United States)

'Ecstasy' or 3,4-methylenedioxy-N-methamphetamine (MDMA) is an amphetamine abused for its euphoric, empathogenic, hallucinatory, and stimulant effects. It is also used to treat certain psychiatric disorders. Common settings for Ecstasy use are nightclubs and "rave" parties where participants consume MDMA and dance to loud music. One concern with the club setting is that exposure to loud sounds can cause permanent sensorineural hearing loss. Another concern is that consumption of MDMA may enhance such hearing loss. Whereas this latter possibility has not been investigated, this study tested the hypothesis that MDMA enhances noise-induced hearing loss (NIHL) by exposing rats to either MDMA, noise trauma, both MDMA and noise, or neither treatment. MDMA was given in a binge pattern of 5 mg/kg per intraperitoneal injections every 2 h for a total of four injections to animals in the two MDMA-treated groups (MDMA-only and Noise + MDMA). Saline injections were given to the animals in the two non-MDMA groups (Control and Noise-only). Following the final injection, noise trauma was induced by a 10 kHz tone at 120 dB SPL for 1 h to animals in the two noise trauma-treated groups (Noise-only and Noise + MDMA). Hearing loss was assessed by the auditory brainstem response (ABR) and cochlear histology. Results showed that MDMA enhanced NIHL compared to Noise-only and that MDMA alone caused no hearing loss. This implies that "clubbers" and "rave-goers" are exacerbating the amount of NIHL when they consume MDMA and listen to loud sounds. In contrast to earlier reports, the present study found that MDMA by itself caused no changes in the click-evoked ABR's wave latencies or amplitudes. PMID:23711768

Church, Michael W; Zhang, Jinsheng S; Langford, Megan M; Perrine, Shane A

2013-05-25

105

'Ecstasy' enhances noise-induced hearing loss.  

UK PubMed Central (United Kingdom)

'Ecstasy' or 3,4-methylenedioxy-N-methamphetamine (MDMA) is an amphetamine abused for its euphoric, empathogenic, hallucinatory, and stimulant effects. It is also used to treat certain psychiatric disorders. Common settings for Ecstasy use are nightclubs and "rave" parties where participants consume MDMA and dance to loud music. One concern with the club setting is that exposure to loud sounds can cause permanent sensorineural hearing loss. Another concern is that consumption of MDMA may enhance such hearing loss. Whereas this latter possibility has not been investigated, this study tested the hypothesis that MDMA enhances noise-induced hearing loss (NIHL) by exposing rats to either MDMA, noise trauma, both MDMA and noise, or neither treatment. MDMA was given in a binge pattern of 5 mg/kg per intraperitoneal injections every 2 h for a total of four injections to animals in the two MDMA-treated groups (MDMA-only and Noise + MDMA). Saline injections were given to the animals in the two non-MDMA groups (Control and Noise-only). Following the final injection, noise trauma was induced by a 10 kHz tone at 120 dB SPL for 1 h to animals in the two noise trauma-treated groups (Noise-only and Noise + MDMA). Hearing loss was assessed by the auditory brainstem response (ABR) and cochlear histology. Results showed that MDMA enhanced NIHL compared to Noise-only and that MDMA alone caused no hearing loss. This implies that "clubbers" and "rave-goers" are exacerbating the amount of NIHL when they consume MDMA and listen to loud sounds. In contrast to earlier reports, the present study found that MDMA by itself caused no changes in the click-evoked ABR's wave latencies or amplitudes.

Church MW; Zhang JS; Langford MM; Perrine SA

2013-08-01

106

High frequency hearing loss in Ullrich-Turner syndrome.  

UK PubMed Central (United Kingdom)

UNLABELLED: A total of 38 patients with Ullrich-Turner syndrome underwent standard otological and audiometric evaluation as well as high frequency audiological tests. Some 26 (68.4%) patients had a history of middle ear infections, and ten (26.3%) had required otolaryngological surgery. Conventional audiometry (125-8000 Hz) demonstrated normal hearing in only 25 of the ears (33%); between 500-4000 Hz, 16 ears (21.0%) had a mixed type and eight ears (10.5%) had conductive hearing loss. High frequency audiometry (8-18 kHz) revealed sensorineural hearing loss in 98.7% of the ears. Our results for conventional audiometry are in accordance with the literature. CONCLUSION: The detection of a high prevalence of hearing loss in the high frequency range brings a significant new perspective to the pursuit of the aetiology of ear and hearing problems in Ullrich-Turner syndrome. This pathology seems to be a premature variant of presbycusis and it may underlie future hearing impairment which will come to clinical attention only after it progresses to conventional testing frequencies. While further studies are underway to evaluate this aspect, routine otological and audiological follow-up of patients with Ullrich-Turner syndrome is warranted from the time of diagnosis.

Güngör N; Böke B; Belgin E; Tunçbilek E

2000-10-01

107

Living with Hearing and Vision Loss Due to Usher Syndrome  

Medline Plus

Full Text Available ... Due to Usher Syndrome Living with Hearing and Vision Loss Due to Usher Syndrome Note: This video ... Video (Quicktime) Transcript of Living with Hearing and Vision Loss Due to Usher Syndrome Video NARRATOR 1: ...

108

Living with Hearing and Vision Loss Due to Usher Syndrome  

Medline Plus

Full Text Available ... Syndrome Living with Hearing and Vision Loss Due to Usher Syndrome Note: This video may take several ... of Living with Hearing and Vision Loss Due to Usher Syndrome Video NARRATOR 1: A woman with ...

109

Mobile phone induced sensorineural hearing loss  

International Nuclear Information System (INIS)

[en] The increased use of mobile phones worldwide has focused interest on the biological effects and possible health outcomes of exposure to radiofrequency fields from mobile phones, and their base stations. Various reports suggest that mobile phone use can cause health problems like fatigue, headache, dizziness, tension and sleep disturbances, however, only limited research data is available in medical literature regarding interaction between electromagnetic fields emitted by mobile phones and auditory function and the possible impact on hearing. We report a case of sensorineural hearing loss due to Global System for Mobile Communication mobile phone use in a 42-year-old male. (author)

2007-01-01

110

Viral and epidemiologic studies of idiopathic sudden hearing loss.  

UK PubMed Central (United Kingdom)

The relationship between viral seroconversions and idiopathic sudden hearing loss (ISHL) is studied. Compared with our control group, the incidence of viral seroconversions is greater among ISHL patients, both for single and multiple viral infections. There was a significantly greater number of patients with seroconversions to mumps, rubeola, varicella-zoster, cytomegalovirus, and influenza B. We were unable to find a relationship between viral seroconversion and type or degree of hearing loss, vertigo, or chance for recovery. The incidences of viral conversion and sudden hearing loss track one another closely, suggesting that viral infection is a major cause of ISHL. During this 3-year study in Boston, ISHL was most prevalent in the spring.

Wilson WR; Veltri RW; Laird N; Sprinkle PM

1983-12-01

111

The comparative study of reading comprehension in normal-hearing and hearing-loss student  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Aim: In different language approaches, reading is considered as a major skill. Language skills comprising listening, speaking, reading and writing are completely interlinked with each other. Thus, providing active application of listening and speaking skills, children will learn reading and writing skills easily. The aim of this research was to compare reading skills of hearing-loss students studying at exceptional schools with normal students of different degrees.Methods: The research was conducted post-traumatically using standardized 2006 PIRLS test. 80 students in fifth grade of exceptional primary schools, and first and fourth grade of exceptional high schools in Tehran City who had severe and or profound hearing loss were randomly selected along with 80 normal students in ordinary schools who were selected using available sampling method.Results: There were significant differences between reading comprehension of hearing-loss and normal students of all three grades (p<0.001). Reading comprehension in female students was significantly higher than the male ones (p<0.001). There were not any significant differences in mean reading comprehension scores of hearing-loss students in different grades which demonstrate that their reading skills had not developed in tandem with their age and school educations.Conclusion: This study shows that one of the significant concerns regarding hearing-loss students is their reading comprehension ability. Considering reading ability as one of the most important acquisitive abilities which students learn at school, evaluation of reading skills of hearing loss students as well as recognition of their strengths and weaknesses in this field is indispensable.

Fatemeh Nikkhou; Saeid Hasanzadeh; Gholamali Afrooz

2012-01-01

112

Stem cell transplantation in noise induced hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To investigate efficacy of bone marrow stem cell implantation in rehabilitation of noise induced hearing loss in rats. MATERIALS AND METHODS: Hearing loss was induced in male rats by a continuous wide-band noise (8-16 kHz/120 dB/120 min). Ten microliter of stem cell containing solution was injected by a Hamilton syringe with 30 G needle through the round window membrane. Hearing status was examined by, distortion product otoacoustic emissions using DP-OAE. Animals were studied in 4 different groups: (1) Normal hearing animals, undergoing sham surgery (no injection done, only round window membrane ruptured and sealed). (2) Deaf animals, undergoing sham surgery. (3) Deaf animals undergoing surgery and injection of solvent (artificial perilymph). (4) Deaf animals undergoing surgery and injection of artificial perilymph containing BMSCs. RESULTS: DP-Gram in rat with normal hearing undergoing sham surgery show that procedure has neither negative impact on normal cochlear nor on deaf cochleas. No significant difference (p=0.25) between ears excludes artificial perilymph as a confounding factor. There is no significant difference between ears in animals receiving BMSCs. CONCLUSIONS: Implanted cells with normal histologic structures have no physiologic function and hearing rehabilitation. Further studies by monitoring the survival of these cells with histologic and appropriate biomarkers will help to investigate differentiation process of these cells.

Ajalloueyan M; Kouhi A; Asgari A; Salem M; Hasanalifard M

2013-04-01

113

Documented instance of restored conductive hearing loss.  

UK PubMed Central (United Kingdom)

The relationship between temporomandibular joint dysfunction and hearing disorders has long been recognized by some healthcare providers (1,2). Fonder reports that "chronic low-grade otitis media is a constant finding in patients who have a disturbance of the stomatognathical structures due to malocclusion" (3). Fingeroth stated that "a constricted maxillary dental arch frequently results in a decrease in nasal permeability...and within this environment a conductive hearing loss may be present" (4). Histological studies confirm the intimate relationship between the TMJ, the tympanic cavity and the eustachian tube (5,6). Nevertheless, craniomandibular origins are frequently overlooked in the medical profession as possible causes for hearing problems. The following case illustrates this point.

Bubon MS

1995-01-01

114

Syndromes of hearing loss associated with visual loss.  

UK PubMed Central (United Kingdom)

Patients with hearing loss depend more on their vision on their communication and vice versa. ENT physician faces difficult situation when he or she consults a patient complaining of hearing loss with a problem of vision. The prevalence of ophthalmic abnormalities in deaf population is also higher compared to their hearing peers. This paper is to summarize the common syndromes associated with visual defect according to the site of affection in the eye. Study design: Review article. Syndromes which result in deaf blind person are different among adults compared to among children. Rubella syndrome and Down syndrome are the main causes of deaf blind people above 18 years of age. While in children, CHARGE syndrome is the main cause of deaf blind children. ENT physician should be aware of these syndromes for earlier detection of deaf blind persons. Deaf blind people need a great deal of help. Communication and education are crucial for them and need to be properly supported.

Abou-Elhamd KA; Eltoukhy HM; Al-Wadaani FA

2013-04-01

115

Statistical model for prediction of hearing loss in patients receiving cisplatin chemotherapy.  

UK PubMed Central (United Kingdom)

IMPORTANCE: This statistical model might be used to predict cisplatin-induced hearing loss, particularly in patients undergoing concomitant radiotherapy. OBJECTIVE: To create a statistical model based on pretreatment hearing thresholds to provide an individual probability for hearing loss from cisplatin therapy and, secondarily, to investigate the use of hearing classification schemes as predictive tools for hearing loss. DESIGN: Retrospective case-control study. SETTING: Tertiary care medical center. PARTICIPANTS: A total of 112 subjects receiving chemotherapy and audiometric evaluation were evaluated for the study. Of these subjects, 31 met inclusion criteria for analysis. MAIN OUTCOME MEASURES: The primary outcome measurement was a statistical model providing the probability of hearing loss following the use of cisplatin chemotherapy. RESULTS: Fifteen of the 31 subjects had significant hearing loss following cisplatin chemotherapy. American Academy of Otolaryngology-Head and Neck Society and Gardner-Robertson hearing classification schemes revealed little change in hearing grades between pretreatment and posttreatment evaluations for subjects with or without hearing loss. The Chang hearing classification scheme could effectively be used as a predictive tool in determining hearing loss with a sensitivity of 73.33%. Pretreatment hearing thresholds were used to generate a statistical model, based on quadratic approximation, to predict hearing loss (C statistic = 0.842, cross-validated = 0.835). The validity of the model improved when only subjects who received concurrent head and neck irradiation were included in the analysis (C statistic = 0.91). A calculated cutoff of 0.45 for predicted probability has a cross-validated sensitivity and specificity of 80%. CONCLUSIONS AND RELEVANCE: Pretreatment hearing thresholds can be used as a predictive tool for cisplatin-induced hearing loss, particularly with concomitant radiotherapy.

Johnson A; Tarima S; Wong S; Friedland DR; Runge CL

2013-03-01

116

Effect of tinnitus on distortion product otoacoustic emissions varies with hearing loss.  

UK PubMed Central (United Kingdom)

PURPOSE: The aim of this study was to measure the effect of tinnitus, while accounting for the effect of hearing loss and aging, on distortion product otoacoustic emissions (DPOAEs). METHOD: DPOAEs were measured twice in both ears in 5 groups of participants: young adults with normal hearing, middle-age adults with normal hearing, adults with high-frequency sensorineural hearing loss, age-matched adults with similar hearing loss and tinnitus, and adults with normal hearing and chronic tinnitus. RESULTS: Multivariate analysis revealed a main effect of hearing loss and age, but no effect of tinnitus, across all 5 groups. Separate tests revealed significant effects of age and tinnitus in the normal-hearing groups and hearing loss in adults with or without tinnitus, but no effect of tinnitus in those with hearing loss. CONCLUSION: DPOAE levels in the group of adults with hearing loss and tinnitus were diminished, but those in the group with normal hearing and tinnitus were enhanced, relative to DPOAE levels in the controls. Outer hair cell function, as indexed by DPOAEs, exhibits a complex association with tinnitus, and this has implications in the use of DPOAEs as a tool both for testing for tinnitus presence and for creating a model of neural mechanisms underlying tinnitus.

Husain FT

2013-06-01

117

Effect of Dyslipidemia on Noise Induced Hearing Loss  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Hearing is one the most important senses of human. Hearing loss is one of the greatest chronic disabilities. Noise induced hearing loss (NIHL) is a common occupational disorder and several factors affect its intensity. One of these factors is individual differences. The aim of present study is the assessment of dyslipidemia’s effect on NIHL. This study was conducted to evaluate association between dyslipidemia and noise induced hearing loss.   Methods: This was an analytic-descriptive study which was conducted in 2010. The factory workers of Rasht industrial city with the following inclusion criteria were selected: environmental noise above 85dB, age below 55 years, no otologic disease or surgery, and no history of usage of ototoxic drugs. A total of 298 workers were assessed. After physical examination and audiometry, we measured the level of serum cholesterol, triglyceride, high and low density lipoprotein of participants. The results were analyzed with the SPSS version 17.0. The p value < 0.05 is considered significant statistically. Results: In this study, 250 men and 48 women were assessed. The mean age of participants was 35.8 years. The participants had high noise exposure of 11 years on average (1-26years). Ninty five of them had NIHL (31.8%). The frequency of serum cholesterol, triglyceride, high and low density of this group were 31.5%, 10.8%, 53.2% and 14.3%, respectively. These levels in the group without NIHL (203 workers) were 38.9%, 12.6%, 58.9% and 21.1%, respectively. There was no statistical significance between these levels in the two groups. By backward logistic regression method, we observed that the duration of employment and gender increased the hearing threshold of 4 KHz frequency in the NIHL group. The odd ratio of hearing loss in male gender was 3.36 (95% confidence interval: 1.61-8.95, p= 0.004). The other effective factors on the hearing threshold of 4 KHz frequency had statistical, but no clinical significant difference in two groups. Conclusion: We observed no statistical significance of dyslipidemia frequency between two groups . In addition to duration of employment, male gender was the other observed related factor with hearing loss in the two groups. This effect may be due to protective effect of estrogen on the hearing level. Studies with more sensitive approaches on a larger sample is advised.

Rahmatullah Banan; Mir Mohammad Jalali; Abtin Heidarzadeh; Seyed Mojtaba Mehrdad; Rezvan Ruhi Sefid Mazgi; Fataneh Bakhshi

2012-01-01

118

Conductive hearing loss in children with autism.  

UK PubMed Central (United Kingdom)

Infantile autism is a serious comprehensive developmental disorder. The diagnosis of hearing loss or its exclusion, which often suggests suspected autism, is very important for early ENT, psychotherapy, and psychiatric treatment. One hundred children diagnosed with autism aged from 3 to 18 years, with a median age of 5 years, were evaluated. The control group of healthy children consisted of 100 children, aged from 3 to 18 years, with a median age of 6 years. Anamnesis and physical examination, including pediatric assessment and otoscopic examination, were carried out on children in both groups. Each child underwent bilateral otoacoustic emission examination in the 0.7, 1, 2, and 4 kHz bands and impedance audiometry examination. The data obtained were subjected to a basic statistical assessment. Chi(2) Pearson's test was used to compare results of tests in both groups. The absence of otoacoustic emission for the 1 and 2 kHz bands was significantly more frequent in the group of autistic children than in the control group. Furthermore, types B and C2 tympanometric curves were significantly more common in the group of autistic children than in the group of healthy children.

Rafal Z

2013-08-01

119

Risk Factors for Hearing Loss in Children following Bacterial Meningitis in a Tertiary Referral Hospital.  

UK PubMed Central (United Kingdom)

Objective. This study aimed to examine hearing function in children admitted with bacterial meningitis to determine the risk factors for sensorineural hearing loss. Setting. The study was conducted in the audiology unit and paediatric wards of Kenyatta National Hospital. Subjects and Methods. The study involved 83 children between the ages of six months and twelve years admitted with bacterial meningitis. The median age for the children examined was 14. On discharge they underwent hearing testing to evaluate for presence and degree of hearing loss. Results. Thirty six of the 83 children (44.4%) were found to have at least a unilateral mild sensorineural hearing loss during initial audiologic testing. Of the children with hearing loss, 22 (26.5%) had mild or moderate sensorineural hearing loss and 14 (16.9%) had severe or profound sensorineural hearing loss. Significant determinants identified for hearing loss included coma score below eight, seizures, cranial nerve neuropathy, positive CSF culture, and fever above 38.7 degrees Celsius. Conclusions. Sensorineural hearing loss was found to be highly prevalent in children treated for bacterial meningitis. There is need to educate healthcare providers on aggressive management of coma, fever, and seizures due to their poor prognostic value on hearing.

Karanja BW; Oburra HO; Masinde P; Wamalwa D

2013-01-01

120

The effects of simulated hearing loss on speech recognition and walking navigation.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The objective was to assess whether a concurrent but independent navigation task exacerbates the effects of hearing loss on speech recognition and whether hearing loss degrades performance of the navigation task during the concurrent but independent listening task. BACKGROUND: Navigation performance and speech comprehension both decrease when a driver follows hard-to-hear concurrent verbal instructions. It remains unknown how much both tasks would be affected when performed concurrently, if tasks were independent. METHOD: Participants performed a listening task by responding to Callsign Acquisition Test (CAT) stimuli at three simulated hearing levels. For each hearing level, one trial was performed with the participant standing still and another trial was performed while navigating a path in a virtual environment using a handheld map. In one more trial, participants navigated a path with no CAT. The proportion of call signs correctly repeated and the total time required to walk the path were measured. RESULTS: CAT scores showed an expected negative effect of hearing loss. Concurrent navigation produced an even larger decrease in CAT score. Hearing loss caused a slight but not significant decrease in navigation task performance. CONCLUSION: A person with hearing loss may communicate less effectively while walking than predicted on the basis of hearing loss alone. The hearing loss, however, does not significantly decrease walking performance in a simple navigation task. APPLICATION: Obtained results may guide soldier performance modeling and requirements for communication systems used during physical activity when a soldier's hearing becomes compromised during dismounted combat operations.

Weatherless RA; Fedele PD; Kehring KL; Letowski TR

2013-04-01

 
 
 
 
121

Head trauma: hearing loss and dizziness.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Because the physicians who care for patients with head trauma may be family practitioners or internists, this article provides these physicians some knowledge of the causes and pathophysiology of such trauma with respect to neurologic sequelae to aid in their decisions to seek consultation with neurologists and otoneurologists in diagnosis and management. METHODS: This article reviews the literature concerning differential diagnosis, appropriate evaluation, and possible treatments of patients who exhibit hearing loss and dizziness after head trauma, whiplash injuries, or both. I also relate those findings to my extensive experience with such neurologic problems. FINDINGS: The findings are grouped according to injuries that cause dizziness, including trauma to the brain stem - eighth nerve complex, the semicircular canals (labyrinthine concussion), benign paroxysmal positional vertigo, Meniere's syndrome -- vestibular symptoms, perilymphatic fistula -- vestibular symptoms, and cervical vertigo; and those that cause hearing loss, including trauma to the brain, eighth nerve, middle ear, cochlear concussion, Meniere's syndrome, and perilymphatic fistula.

Fitzgerald DC

1996-03-01

122

Sudden sensorineural hearing loss and hemodialysis.  

Science.gov (United States)

The etiology of sensorineural hearing loss (SNHL) associated with renal failure and hemodialysis is controversial. Possible mechanisms include a shared antigenicity between the kidney and the labyrinths, osmotic alteration caused by hemodialysis, and the ototoxic effect of diuretics. We present 2 cases of SNHL associated with renal failure and its treatment. One patient was a 35-year-old man who developed profound SNHL after 5 sessions of hemodialysis, and the other was a 36-year-old woman who developed severe to profound SNHL after 7 sessions. It is our impression that both hearing losses might have been attributable to osmotic disequilibrium in the labyrinth or to an acute labyrinthine injury caused by contamination of the blood by the degraded product of an old cellulose acetate hemodialyzer membrane; the hemodialyzer had been in use for 15 years. PMID:17240706

Lasisi, Olawale A; Salako, Babatunde L; Kadiri, Solomon; Arije, Ayo; Oko-Jaja, Richard; Ipadeola, Arinola; Olatoke, Fatai

2006-12-01

123

Bilateral Pial siderosis and hearing loss  

International Nuclear Information System (INIS)

Seven adult patients with bilateral progressive hearing loss (six male, one female; aged 40-74 years) were studied with a high-field strength (1.5-T) magnetic resonance (MR) system after previous negative workup with either air contrast or intravenous contrast medium-enhanced computed tomography (CT). In all instances, the patients showed extensive evidence of pial siderosis outlining the posterior fossa subarachnoid space. The siderosis was manifested (on long repetition time images) as an increasing susceptibility effect (hypointensity) with a prolongation of echo time. The results of this study indicate that a negative CT examination is inadequate in patients with bilateral hearing loss and that when evidence of siderosis is found on MR images, an etiology for prior subarachnoid hemorrhage must be pursued.

1988-12-02

124

Childhood hearing loss and risk profile in a South African population.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To describe the nature of hearing loss and associated risk profile in a South African population of infants and children diagnosed at a pediatric referral clinic. METHODS: A retrospective review of patient files for a pediatric auditory evoked potential clinic in Pretoria was conducted (January 2007-December 2011). Collected data included demographical information, risk factors from case history questionnaire, diagnosis (type and degree of hearing loss), documented age of caregiver suspicion and age of first diagnosis. RESULTS: Hearing loss was present in 73% (73/100) of cases evaluated. Permanent hearing losses (SNHL, ANSD and mixed) constituted 76% of losses. Unilateral hearing losses constituted 8% of SNHL and 20% of conductive hearing loss. ANSD was diagnosed in 21.4% and SNHL in 78.6% of permanent non-conductive hearing loss cases. The most prevalent SNHL risk was family history of hearing loss and for ANSD it was admittance to the NICU for more than 5 days. The majority of the sample was diagnosed with a permanent bilateral SNHL and ANSD after 36 months of age (47%) despite 40% already suspected of having a hearing loss before 12 months of age. CONCLUSIONS: A high prevalence of ANSD was found with preventable risk factors often indicated. Age of diagnosis was significantly delayed, evidencing the lack of early hearing detection services in South Africa. The majority of children were diagnosed at ages precluding optimal benefits from early detection and subsequent intervention.

Swanepoel de W; Johl L; Pienaar D

2013-03-01

125

Noise Induced Hearing Loss of Forest Workers in Turkey  

Directory of Open Access Journals (Sweden)

Full Text Available In this study, a total number of 114 workers who were in 3 different groups in terms of age and work underwent audiometric analysis. In order to determine whether there was a statistically significant difference between the hearing loss levels of the workers who were included in the study, variance analysis was applied with the help of the data obtained as a result of the evaluation. Correlation and regression analysis were applied in order to determine the relations between hearing loss and their age and their time of work. As a result of the variance analysis, statistically significant differences were found at 500, 2000 and 4000 Hz frequencies. The most specific difference was observed among chainsaw machine operators at 4000 Hz frequency, which was determined by the variance analysis. As a result of the correlation analysis, significant relations were found between time of work and hearing loss in 0.01 confidence level and between age and hearing loss in 0.05 confidence level. Forest workers using chainsaw machines should be informed, they should wear or use protective materials and less noising chainsaw machines should be used if possible and workers should undergo audiometric tests when they start work and once a year.

M. Tunay; K. Melemez

2008-01-01

126

Observations from a musician with hearing loss.  

Science.gov (United States)

Extensive personal experience with professional recording and audio signal processing technology has enabled the author to continue his music career after experiencing sudden sensorineural hearing loss. The iPhone™ is one such device that has been found useful for many music and general listening situations that would otherwise be intractable. Additional techniques and technologies are described that the author has found useful for specific situations, including music composition, rehearsal, and enjoyment. PMID:23203415

Einhorn, Richard

2012-11-30

127

Observations from a musician with hearing loss.  

UK PubMed Central (United Kingdom)

Extensive personal experience with professional recording and audio signal processing technology has enabled the author to continue his music career after experiencing sudden sensorineural hearing loss. The iPhone™ is one such device that has been found useful for many music and general listening situations that would otherwise be intractable. Additional techniques and technologies are described that the author has found useful for specific situations, including music composition, rehearsal, and enjoyment.

Einhorn R

2012-09-01

128

Hereditary hearing loss with thyroid abnormalities.  

UK PubMed Central (United Kingdom)

Mutations in SLC26A4 can cause deafness and goiter in Pendred syndrome (PDS) or isolated non-syndromic enlargement of the vestibular aqueduct (NSEVA). PDS is one of the most common hereditary causes of deafness. It is characterized by autosomal-recessive inheritance of sensorineural hearing loss, enlarged vestibular aqueducts (EVA), and an iodide organification defect with or without goiter. The diagnosis is confirmed by detection of two mutant alleles of SLC26A4 in a patient with EVA. The perchlorate discharge test can detect the underlying thyroid biochemical defect and is useful for the evaluation of goiter or for the clinical diagnosis of PDS in a patient with a non-diagnostic SLC26A4 genotype. SLC26A4 encodes the pendrin polypeptide, an anion exchanger that, in recombinant expression systems, transports chloride, bicarbonate, and iodide. Investigation of pendrin function in the inner ear has been facilitated by the Slc26a4(?) (knockout) mouse model, but the exact mechanism of its hearing loss remains unclear, as does pendrin's principal transport function in the inner ear. Treatment of PDS is focused upon rehabilitation of hearing loss, and surveillance and management of goiter and, less commonly, hypothyroidism.

Choi BY; Muskett J; King KA; Zalewski CK; Shawker T; Reynolds JC; Butman JA; Brewer CC; Stewart AK; Alper SL; Griffith AJ

2011-01-01

129

Improved horizontal directional hearing in bone conduction device users with acquired unilateral conductive hearing loss.  

UK PubMed Central (United Kingdom)

We examined horizontal directional hearing in patients with acquired severe unilateral conductive hearing loss (UCHL). All patients (n = 12) had been fitted with a bone conduction device (BCD) to restore bilateral hearing. The patients were tested in the unaided (monaural) and aided (binaural) hearing condition. Five listeners without hearing loss were tested as a control group while listening with a monaural plug and earmuff, or with both ears (binaural). We randomly varied stimulus presentation levels to assess whether listeners relied on the acoustic head-shadow effect (HSE) for horizontal (azimuth) localization. Moreover, to prevent sound localization on the basis of monaural spectral shape cues from head and pinna, subjects were exposed to narrow band (1/3 octave) noises. We demonstrate that the BCD significantly improved sound localization in 8/12 of the UCHL patients. Interestingly, under monaural hearing (BCD off), we observed fairly good unaided azimuth localization performance in 4/12 of the patients. Our multiple regression analysis shows that all patients relied on the ambiguous HSE for localization. In contrast, acutely plugged control listeners did not employ the HSE. Our data confirm and further extend results of recent studies on the use of sound localization cues in chronic and acute monaural listening.

Agterberg MJ; Snik AF; Hol MK; van Esch TE; Cremers CW; Van Wanrooij MM; Van Opstal AJ

2011-02-01

130

Improved horizontal directional hearing in bone conduction device users with acquired unilateral conductive hearing loss.  

Science.gov (United States)

We examined horizontal directional hearing in patients with acquired severe unilateral conductive hearing loss (UCHL). All patients (n = 12) had been fitted with a bone conduction device (BCD) to restore bilateral hearing. The patients were tested in the unaided (monaural) and aided (binaural) hearing condition. Five listeners without hearing loss were tested as a control group while listening with a monaural plug and earmuff, or with both ears (binaural). We randomly varied stimulus presentation levels to assess whether listeners relied on the acoustic head-shadow effect (HSE) for horizontal (azimuth) localization. Moreover, to prevent sound localization on the basis of monaural spectral shape cues from head and pinna, subjects were exposed to narrow band (1/3 octave) noises. We demonstrate that the BCD significantly improved sound localization in 8/12 of the UCHL patients. Interestingly, under monaural hearing (BCD off), we observed fairly good unaided azimuth localization performance in 4/12 of the patients. Our multiple regression analysis shows that all patients relied on the ambiguous HSE for localization. In contrast, acutely plugged control listeners did not employ the HSE. Our data confirm and further extend results of recent studies on the use of sound localization cues in chronic and acute monaural listening. PMID:20838845

Agterberg, Martijn J H; Snik, Ad F M; Hol, Myrthe K S; van Esch, Thamar E M; Cremers, Cor W R J; Van Wanrooij, Marc M; Van Opstal, A John

2010-09-14

131

The dose-response relationship between in-ear occupational noise exposure and hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVES: Current understanding of the dose-response relationship between occupational noise and hearing loss is based on cross-sectional studies prior to the widespread use of hearing protection, and with limited data regarding noise exposures below 85 dBA. We report on the hearing loss experience of a unique cohort of industrial workers, with daily monitoring of noise inside of hearing protection devices. METHODS: At an industrial facility, workers exhibiting accelerated hearing loss were enrolled in a mandatory programme to monitor daily noise exposures inside of hearing protection. We compared these noise measurements (as time-weighted LAVG) to interval rates of high-frequency hearing loss over a 6-year period using a mixed-effects model, adjusting for potential confounders. RESULTS: Workers' high-frequency hearing levels at study inception averaged more than 40 dB Hearing threshold level (HTL). Most noise exposures were less than 85 dBA (mean LAVG 76 dBA, IQR 74-80 dBA). We found no statistical relationship between LAvg and high-frequency hearing loss (p=0.53). Using a metric for monthly maximum noise exposure did not improve model fit. CONCLUSIONS: At-ear noise exposures below 85 dBA did not show an association with risk of high-frequency hearing loss among workers with substantial past noise exposure and hearing loss at baseline. Therefore, effective noise control to below 85 dBA may lead to significant reduction in occupational hearing loss risk in such individuals. Further research is needed on the dose-response relationship of noise and hearing loss in individuals with normal hearing and little prior noise exposure.

Rabinowitz PM; Galusha D; Dixon-Ernst C; Clougherty JE; Neitzel RL

2013-07-01

132

Extending the IOI to significant others and to non-hearing-aid-based interventions.  

UK PubMed Central (United Kingdom)

Two extensions of the International Outcome Inventory for Hearing Aids are described: the first is designed for the significant other (SO) (IOI-HA-SO), and the second for alternative interventions for hearing difficulties (IOI-AI). A feature of the IOI-HA-SO is that several items are modified to inquire about effects of the partner's hearing loss on the SO. The IOI-AI is designed to cover effects of use of listening aids other than personally worn hearing aids, use of hearing tactics, and aural surgery.

Noble W

2002-01-01

133

Occupational noise-induced hearing loss in India  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Noise is the insidious of all industrial pollutants, involving every industry and causing severe hearing loss in every country in the world. Exposure to excessive noise is the major avoidable cause of permanent hearing impairment. Worldwide, 16% of the disabling hearing loss in adults is attributed ...

Nandi, Subroto S.; Dhatrak, Sarang V.

134

Occupational noise-induced hearing loss in India  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Noise is the insidious of all industrial pollutants, involving every industry and causing severe hearing loss in every country in the world. Exposure to excessive noise is the major avoidable cause of permanent hearing impairment. Worldwide, 16% of the disabling hearing loss in adults is attr...

Nandi Subroto; Dhatrak Sarang

135

The impact of hearing loss on the quality of life in adults  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction. The hearing apparatus is one of the most important factors related to the development of oral communication. Thus, hearing disorders and deafness lead to severe handicap. Hearing impairment in adults cause verbal communication disorders that influence psychical, emotional and social functioning. Nowadays, there is a noticeable world tendency towards improving hard of hearing person’s quality of life. Objective. Objective was to assess the association between hearing impairment and health-related quality of life. Methods. A hundred adults with billateral hearing impairment underwent hearing examination and answered the Hering Handicap Inventory for the Elderly-Screening (HHIE-S, Ventry and Weinstein), specific for hearing impairment. Results. Almost half of all participants (44%) had a moderate hearing loss, and 36% had a mild loss. Infrequently, participants had a severe degree of hearing loss (13%) and deafness (7%). Self reported hearing handicap revealed significant emotional, social and situational dysfunctions (?2=40.960; df=1; p<0.01). Severity of hearing loss was significantly correlated with hearing handicap (r=0.212; p<0.05). More often, participants revealed social and situational than emotional hearing handicap (?2=131.89; df=100; p<0.05). Only 12% of all participants habitually used hearing aids, and they observed a significantly better quality of life scores (?2=6.23; df=1; p<0.05). Conclusion. Health-related quality of life must be estimated as a factor of great importance. Investigations should involve a more extansive population with hearing loss and a national programme should be started.

Tatovi? Milica; Babac Snežana; ?eri? Dragoslava; Ani?i? Ružica; Ivankovi? Zoran

2011-01-01

136

Evaluating a prediction model for infant hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVES/HYPOTHESIS: The objective of this study was to determine whether a prognostic model using risk factors for hearing loss could predict the chance that infants who failed a newborn hearing screen would subsequently be found to have hearing loss diagnosed by auditory brainstem response testing. STUDY DESIGN: Individual retrospective case-control study. METHODS: We studied 229 infants with hearing loss compared with 458 infants with normal hearing. All infants had undergone natural sleep or sedated auditory brainstem response, predominantly for not passing a newborn hearing screen. Risk factors, birth history, and other information were extracted via medical record review. Multiple logistic regression analyses identified independent predictors of hearing loss. RESULTS: Four risk factors were independently predictive of hearing loss diagnosed by sleep or sedated auditory brainstem response: prematurity, 5-minute APGAR score???6, intracranial complication, and craniofacial abnormality. A prognostic model developed from these risk factors was associated with a 15% rate of hearing loss in stage I, 52% rate of hearing loss in stage II, and 96% rate of hearing loss in stage III. CONCLUSIONS: The presence of any one of four independently predictive risk factors in infants who did not pass newborn hearing screen was associated with a 50% rate of hearing loss; having three or more was associated with a 90% rate of hearing loss. Knowing that an infant is at high risk of hearing loss can motivate parents to follow up with diagnostic auditory brainstem response testing so that early identification can lead to early intervention. LEVEL OF EVIDENCE: 2b. Laryngoscope, 2013.

Lieu JE; Ratnaraj F; Ead B

2013-04-01

137

Smartphone-based hearing test as an aid in the initial evaluation of unilateral sudden sensorineural hearing loss.  

UK PubMed Central (United Kingdom)

Sudden sensorineural hearing loss (SSNHL) can cause significant morbidity. Treatment with steroids can improve outcome. Delay in initiation of treatment reduces the chance to regain hearing. For this reason SSNHL is considered an emergency. Diagnosis is based on history, physical examination and a standard audiogram, the latter requiring specialized equipment and personnel. Standard audiogram may not be available at the time and place of patient presentation. A smartphone or tablet computer-based hearing test may aid in the decision to prescribe steroids in this setting. In this study the uHearhearing test application was utilized. The output of this ear-level air conduction hearing test is reported in hearing grades for 6 frequencies ranging from 250 to 6000 Hz. A total of 32 patients with unilateral SSNHL proven by a standard audiogram were tested. The results of standard and iPod hearing tests were compared. Based on the accepted criterion of SSNHL (at least 30 dB loss - or 2 hearing grades - in 3 consecutive frequencies) the test had a sensitivity of 0.76 and specificity of 0.91. Using a less stringent criterion of a loss of 2 hearing grades over at least 2 frequencies the sensitivity was 0.96 and specificity 0.86. The correlation coefficient for the comparison of the average hearing grade across the 6 measured frequencies of the study and standard audiogram was 0.83. uHear more accurately reflected hearing thresholds at mid and high tones. Similarly to previously published data, low frequency thresholds could be artificially elevated. In conclusion, uHear can be useful in the initial evaluation of patients with single-sided SSNHL by providing important information guiding the decision to initiate treatment before a standard audiogram is available.

Handzel O; Ben-Ari O; Damian D; Priel MM; Cohen J; Himmelfarb M

2013-01-01

138

Smartphone-based hearing test as an aid in the initial evaluation of unilateral sudden sensorineural hearing loss.  

Science.gov (United States)

Sudden sensorineural hearing loss (SSNHL) can cause significant morbidity. Treatment with steroids can improve outcome. Delay in initiation of treatment reduces the chance to regain hearing. For this reason SSNHL is considered an emergency. Diagnosis is based on history, physical examination and a standard audiogram, the latter requiring specialized equipment and personnel. Standard audiogram may not be available at the time and place of patient presentation. A smartphone or tablet computer-based hearing test may aid in the decision to prescribe steroids in this setting. In this study the uHearhearing test application was utilized. The output of this ear-level air conduction hearing test is reported in hearing grades for 6 frequencies ranging from 250 to 6000 Hz. A total of 32 patients with unilateral SSNHL proven by a standard audiogram were tested. The results of standard and iPod hearing tests were compared. Based on the accepted criterion of SSNHL (at least 30 dB loss - or 2 hearing grades - in 3 consecutive frequencies) the test had a sensitivity of 0.76 and specificity of 0.91. Using a less stringent criterion of a loss of 2 hearing grades over at least 2 frequencies the sensitivity was 0.96 and specificity 0.86. The correlation coefficient for the comparison of the average hearing grade across the 6 measured frequencies of the study and standard audiogram was 0.83. uHear more accurately reflected hearing thresholds at mid and high tones. Similarly to previously published data, low frequency thresholds could be artificially elevated. In conclusion, uHear can be useful in the initial evaluation of patients with single-sided SSNHL by providing important information guiding the decision to initiate treatment before a standard audiogram is available. PMID:23689282

Handzel, Ophir; Ben-Ari, Oded; Damian, Doris; Priel, Maayan M; Cohen, Jacob; Himmelfarb, Mordechai

2013-05-14

139

Smartphone-Based Hearing Test as an Aid in the Initial Evaluation of Unilateral Sudden Sensorineural Hearing Loss.  

UK PubMed Central (United Kingdom)

Sudden sensorineural hearing loss (SSNHL) can cause significant morbidity. Treatment with steroids can improve outcome. Delay in initiation of treatment reduces the chance to regain hearing. For this reason SSNHL is considered an emergency. Diagnosis is based on history, physical examination and a standard audiogram, the latter requiring specialized equipment and personnel. Standard audiogram may not be available at the time and place of patient presentation. A smartphone or tablet computer-based hearing test may aid in the decision to prescribe steroids in this setting. In this study the uHearhearing test application was utilized. The output of this ear-level air conduction hearing test is reported in hearing grades for 6 frequencies ranging from 250 to 6000 Hz. A total of 32 patients with unilateral SSNHL proven by a standard audiogram were tested. The results of standard and iPod hearing tests were compared. Based on the accepted criterion of SSNHL (at least 30 dB loss - or 2 hearing grades - in 3 consecutive frequencies) the test had a sensitivity of 0.76 and specificity of 0.91. Using a less stringent criterion of a loss of 2 hearing grades over at least 2 frequencies the sensitivity was 0.96 and specificity 0.86. The correlation coefficient for the comparison of the average hearing grade across the 6 measured frequencies of the study and standard audiogram was 0.83. uHear more accurately reflected hearing thresholds at mid and high tones. Similarly to previously published data, low frequency thresholds could be artificially elevated. In conclusion, uHear can be useful in the initial evaluation of patients with single-sided SSNHL by providing important information guiding the decision to initiate treatment before a standard audiogram is available.

Handzel O; Ben-Ari O; Damian D; Priel MM; Cohen J; Himmelfarb M

2013-05-01

140

The pathogenesis of Noise Induced Hearing Loss  

Directory of Open Access Journals (Sweden)

Full Text Available NIHL occurs when too much sound intensity is transmitted into and through the auditory system and can be occur following a shot gun or the exposure to a moderately intense sound for a long period of time. NIHL caused by acoustic trauma refers to permanent cochlear damage from a one-time exposure to excessive sound pressure. This form of NIHL commonly results from exposure to high-intensity sounds such as explosions, gunfire, a large drum hit loudly and firecrackers. Meanwhile the sound intensity, duration of exposure and personal hearing thresholds as the effective factors in the amount of noise induced hearing loss should not be overlooked.  Since numerous investigations have been performed about intense sudden sound we will discuss it in detail in the current article.

Seyyed Abbas Mir Vakili

1999-01-01

 
 
 
 
141

Hearing loss among workers exposed to moderate concentrations of solvents.  

UK PubMed Central (United Kingdom)

OBJECTIVES: It is known that some industrial organic solvents are ototoxic. This study was aimed at evaluating the hearing effects of a mixture of organic solvents alone or in combination with noise on employees in paint and lacquer enterprises. The concentration of solvents was below the occupational exposure limits (OEL) for most of the subjects. METHODS: Altogether 517 subjects were divided into the following three groups: persons with no risk due to noise or organic solvent exposure at the workplace, workers exposed to organic solvents only, and workers exposed to both organic solvents and noise. RESULTS: The relative risk (RR) of hearing loss in the solvent-only exposure group was significantly increased (RR 4.4 and RR 2.8 for noise exposure of < 80 dB-A and < 85 dB-A, respectively) in a wide range of frequencies (2-8 kHz). No additional risk in the solvent + noise exposure group was found (RR 2.8). Hearing thresholds were significantly poorer in a wide range of frequencies (1-8 kHz) for both groups exposed to solvents, when compared with the reference group. The mean hearing thresholds at frequencies of 2-4 kHz were poorer for workers exposed to solvents + noise than for the solvent-only group; this finding suggests an additional effect for noise. However, there was no correlation between hearing loss and the extent of solvent exposure. CONCLUSIONS: The results indicate that occupational organic solvent exposure at moderate concentrations increases the risk of hearing loss, and the ototoxic effects should be considered when the health effects of exposed workers are monitored.

Sliwinska-Kowalska M; Zamyslowska-Szmytke E; Szymczak W; Kotylo P; Fiszer M; Dudarewicz A; Wesolowski W; Pawlaczyk-Luszczynska M; Stolarek R

2001-10-01

142

Unilateral Hearing Loss: the Benefit of Auditory Localization after Adaptation of Hearing Aids Individual  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: A unilateral hearing loss is characterized by decreased hearing in one ear. Objective: To evaluate the benefit on the location after hearing the adaptation of hearing aids Individual (HA) in individuals with unilateral hearing loss. Method: A prospective study of 31 individuals aged between 18 and 75 years and both genders with unilateral hearing loss of various types and grades, answered a questionnaire to evaluate the location of the sound source, by using the "Survey of hearing ability of the location of the sound source." The instrument was applied in two situations: without the use of HA and the use of hearing aids. Results: Patients with mild hearing loss and received a moderate score of 3.35 with use of hearing aids and hearing loss, severe and profound absence of an improvement of 3.05 1.39 and 1.38 respectively. Conclusion:Benefits were obtained with the use of hearing aids on the auditory localization in subjects with unilateral hearing loss, emphasizing the importance of the use of amplification.

Mondelli, Maria Fernanda Capoani Garcia; Jacob, Regina Tangerino de Souza; Ribeiro, Juliana Pontalti; Felici, Maria da Glória Furlani de Mendonça; Sanches, Rita de Cássia Pires

2010-01-01

143

Hearing losses in wholetime firefighters occurring early in their careers.  

UK PubMed Central (United Kingdom)

BACKGROUND: Most research on firefighter hearing loss has concentrated on effects over a substantial part of, or entire, firefighting career. AIMS: To examine short-term changes in hearing in a group of local authority firefighters during their early careers METHODS: Results of pure-tone audiometry examinations on enlistment and assessment for initial issue of a large goods vehicle (LGV) driving licence were compared. RESULTS: Altogether, 118 firefighters, all male, were examined for an LGV licence over a 2.5-year period to September 2005. Data were available for 89/99 right/left ears on enlistment and 99/100 for LGV. Mean time between examinations was 4.1 years (range 1.4-12.6 years). By the LGV examination, there was deterioration in 69/99 right and 77/100 left ears, with the hearing loss in 8% of right and 13% of left ears falling into the 'warning' or 'referral' categories (Control of Noise at Work Regulations 2005) compared with 1% at enlistment. These differences reached statistical significance (P < 0.05 and < 0.001, respectively) CONCLUSIONS: Statistically significant hearing losses occur in some firefighters during the early stages of their careers. Further work needs to be done to establish if this continues, and steps taken to reduce the noise hazard at work.

Ide CW

2011-10-01

144

Occupational noise-induced hearing loss in Indian steel industry workers: an exploratory study.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The present study focused on exploring the current level of hearing protection and subsequently determined the prevalence of occupational noise-induced hearing loss among casting and forging industry workers. BACKGROUND: The casting and forging industry provides employment to a significant portion of the population. METHOD: The level of hearing protection was assessed through questionnaire survey of 572 workers. Out of these workers, 165 and another control group of 57 participants were assessed by formal audiometry. Audiometric tests were conducted at frequencies of 1.0 KHz to 8.0 KHz.The occurrence of hearing loss was determined on the basis of a hearing threshold level with a low fence of 25 dB. Student's test and ANOVA were used to compare the various groups; a p value < .05 was considered statistically significant. RESULTS: More than 90% of the workers sampled showed significant hearing loss at medium and high frequencies. The analyses revealed a higher prevalence of significant hearing loss among the forging workers compared with the workers associated with the other activities. CONCLUSIONS: The workers of the Indian steel industry are highly exposed to occupational noise. The majority of workers are not protected from noise-induced hearing loss. There is a need to provide special ear protectors for workers engaged in forging. A complete hearing protection program, including training, audiometry, job rotation, and the use of hearing protection devices, needs to be introduced.

Singh LP; Bhardwaj A; Deepak KK

2013-04-01

145

Obesity is associated with sensorineural hearing loss in adolescents.  

UK PubMed Central (United Kingdom)

OBJECTIVES/HYPOTHESIS: Childhood obesity, defined as body mass index (BMI)???95%, is a significant health problem associated with a variety of disorders, and in adults it has been found to be a risk factor for hearing loss. We investigated the hypothesis that obese children are at increased risk of sensorineural hearing loss (SNHL). STUDY DESIGN: A complex, multistage, stratified geographic area design for collecting representative data from noninstitutionalized U.S. population. METHODS: Relevant cross-sectional data from the National Health and Nutrition Examination Survey, 2005 to 2006, for 1,488 participants 12 to 19 years of age was examined. Subjects were classified as obese if their BMI???95th percentile. SNHL was defined as average pure-tone level greater than 15 dB for 0.5, 1, and 2 kHz (low frequency) and 3, 4, 6, and 8 kHz (high frequency). RESULTS: Compared to normal weight participants (BMI 5%-85%), obesity in adolescents was associated with elevated pure tone hearing thresholds and greater prevalence of unilateral low-frequency SNHL (15.2 vs. 8.3%, P?=?0.01). In multivariate analyses, obesity was associated with a 1.85 fold increase in the odds of unilateral low-frequency SNHL (95% CI: 1.10-3.13) after controlling for multiple hearing-related covariates. CONCLUSIONS: We demonstrate for the first time that obesity in childhood is associated with higher hearing thresholds across all frequencies and an almost 2-fold increase in the odds of unilateral low-frequency hearing loss. These results add to the growing literature on obesity-related health disturbances and also add to the urgency in instituting public health measures to reduce it. LEVEL OF EVIDENCE: 2b. Laryngoscope, 2013.

Lalwani AK; Katz K; Liu YH; Kim S; Weitzman M

2013-06-01

146

MR imaging of sensory neural hearing loss  

International Nuclear Information System (INIS)

This paper describes MR findings in patients with sensorineural hearing loss (SNHL) who do not have acoustic neuromas. Twenty-eight patients with SNHL were evaluated with pre- and postgadolinium thin-section axial T1-weighted imaging and axial T2- weighted imaging through the whole brain. Eleven patients had lesions in the labyrinth. Ten of the 11 lesions enhanced after gadolinium administration. The diagnoses included viral labyrinthitis (three patients), syphilitic labyrinthitis (two patients), bacterial labyrinthitis (one patient), vestibular neuromas (three patients), ostosclerosis (one patient), and intravestibular hemorrhage (one patient).

1990-01-01

147

Factors associated with the occurrence of hearing loss after pneumococcal meningitis  

DEFF Research Database (Denmark)

Background. On the basis of a nationwide registration during a 5-year period (1999-2003), the frequency and severity of hearing loss was investigated retrospectively in 343 consecutive Danish patients who survived pneumococcal meningitis, to identify important risk factors (including the pneumococcal serotype) for development of hearing loss. Methods. Results of blood and cerebrospinal fluid (CSF) biochemistry, bacterial serotyping, follow-up audiological examinations, and medical records were collected, and disease-related risk factors for hearing loss were identified. The mean pure-tone hearing threshold levels were compared with normative data. Results. Of 240 patients examined by use of audiometry, 129 (54%) had a hearing deficit, and 50 (39%) of these 129 patients were not suspected of hearing loss at discharge from hospital. Of the 240 patients, 16 (7%) had profound unilateral hearing loss, and another 16 (7%) had bilateral profound hearing loss. Significant risk factors for hearing loss were advanced age, the presence of comorbidity, severity of meningitis, a low CSF glucose level, a high CSF protein level, and a certain pneumococcal serotype (P <.05). By applying multivariate logistic regression analysis, we found that advanced age, female sex, and a certain serotype were significant risk factors, because fewer patients with serotype 6B had hearing loss than did patients with serotype 12F (P = .03), which was the most commonly occurring serotype. Conclusion. Hearing loss is common after pneumococcal meningitis, and audiometry should be performed on all those who survive pneumococcal meningitis. Important risk factors for hearing loss are advanced age, female sex, severity of meningitis, and bacterial serotype

WorsØe, Lise Lotte; Caye-Thomasen, P.

2010-01-01

148

The effects of tinnitus and/or hearing loss on the Symptom Checklist-90-Revised test.  

UK PubMed Central (United Kingdom)

OBJECTIVE: This study aims to evaluate the psychological attitudes of patients with tinnitus by using The Symptom Checklist-90-Revised and to investigate the relationship between hearing loss and attributed psychological attitudes. MATERIALS AND METHODS: 142 subjects (73 female, 69 male) divided into 4 groups: Group 1 (32 patients with tinnitus and hearing loss-), Group 2 (38 patients with tinnitus), Group 3 (36 patients with hearing loss), Group 4 (36 healthy subjects without tinnitus and hearing loss-control group). The Symptom Checklist-90-Revised (SCL-90-R) test was used to detect the subjects' tendency for psychological problems due to tinnitus and/or hearing loss. RESULTS: Mean values of Somatization (SOM), Obsessive-Compulsive (O-C) and Additional Scale (AS) were higher than cut-off points of 1.00 for Groups 1 and 2 (tinnitus and/or hearing loss). In patients with tinnitus and/or hearing loss, SOM, O-C, Depression (DEP), AS and Global Severity Index (GSI) were significantly higher than patients with hearing loss and control group. By multiple linear regression analysis, tinnitus was the significantly detected confounding factor for increase of SOM, O-C, Interpersonal Sensitivity (I-S), DEP, Hostility (HOS), Paranoid Ideation (PAR), AS and GSI parameters. CONCLUSION: It was concluded that tinnitus could induce some psychological symptoms such as depression; and this is independent of hearing loss. Tinnitus with or without hearing loss is the essential factor for causing psychological problems in patients. Tinnitus duration is not important in the scene of psychological status of the patients. This result shows that, age, gender (male, female), chronic or acute tinnitus experience, and having hearing loss did not cause too much problems in patients. But tinnitus experience in every form (for the present study, intermediate level subjective tinnitus) is significantly important confounding factor for affecting psychological status of the patients.

Genç GA; Muluk NB; Belgin E

2013-04-01

149

Evaluation of Occupational Hearing Loss in Fire Fighters in Tehran  

Directory of Open Access Journals (Sweden)

Full Text Available Hearing loss is a controversial occupational disease in fire fighters because exposure to hazardous levels of noise in this job is so variable and unpredictable. In this study, audiometric assessments were performed on 117 fire fighters to evaluate their hearing loss. The results showed that the average fire fighter has a characteristic noise-induced threshold shift, with maximum hearing loss occurring at 6000 Hz. The hearing loss at the test frequencies was related to age, although the association exceeded that of general population only in 6000 Hz frequency in left ear (p=0.021). Despite finding a pattern of threshold shift typical of occupational hearing loss, it must be noted that after controlling for age, there was no strong relation between length of time on the job and the degree of hearing loss. It seems that more extensive studies are needed to evaluate this relationship.

F Asghari; A Fotouhi; A Sharifian; A Karimi

2004-01-01

150

A brief overview of factors affecting speech intelligibility of people with hearing loss: implications for amplification.  

UK PubMed Central (United Kingdom)

PURPOSE: To determine the predictability of speech intelligibility of people with different degrees of hearing loss from audibility and other factors. METHOD: After a brief overview of why people with hearing loss have greater difficulty in understanding speech than people with normal hearing, we describe a study that was aimed to predict speech intelligibility from audibility, psychoacoustic abilities, cognitive ability and age. RESULTS: The study showed that the ability of people with hearing loss to extract speech information from an audible signal decreased with increase in hearing loss. This hearing loss desensitization was significantly related to hearing thresholds, sharpness of psychophysical tuning curves, presence of dead regions, age and cognitive ability. After allowing for the effects of hearing loss, speech intelligibility was significantly related to age and cognitive ability. The effects did not vary with frequency. CONCLUSIONS: The current evidence supports the allowance of hearing loss desensitization in prescribing amplification that is aimed to maximise speech intelligibility. There is insufficient evidence to recommend the inclusion of estimates of frequency resolution or dead regions in prescribing amplification.

Ching TY; Dillon H

2013-08-01

151

Age-related changes in auditory and cognitive abilities in elderly persons with hearing aids fitted at the initial stages of hearing loss  

Directory of Open Access Journals (Sweden)

Full Text Available In this study, we investigated the relation between the use of hearing aids at the initial stages of hearing loss and age-related changes in the auditory and cognitive abilities of elderly persons. 12 healthy elderly persons participated in an annual auditory and cognitive longitudinal examination for three years. According to their hearing level, they were divided into 3 subgroups - the normal hearing group, the hearing loss without hearing aids group, and the hearing loss with hearing aids group. All the subjects underwent 4 tests: pure-tone audiometry, syllable intelligibility test, dichotic listening test (DLT), and Wechsler Adult Intelligence Scale-Revised (WAIS-R) Short Forms. Comparison between the 3 groups revealed that the hearing loss without hearing aids group showed the lowest scores for the performance tasks, in contrast to the hearing level and intelligibility results. The other groups showed no significant difference in the WAIS-R subtests. This result indicates that prescription of a hearing aid during the early stages of hearing loss is related to the retention of cognitive abilities in such elderly people. However, there were no statistical significant correlations between the auditory and cognitive tasks.

C. Obuchi; T. Harashima; M. Shiroma?

2011-01-01

152

Clinical analysis of patients with idiopathic sudden sensorineural hearing loss and benign paroxysmal positional vertigo.  

UK PubMed Central (United Kingdom)

CONCLUSIONS: Thirteen (5.4%) of patients with idiopathic sudden sensorineural hearing loss (ISSNHL) had benign paroxysmal positional vertigo (BPPV). Most of the patients showed profound hearing loss and had BPPV of the lateral canal. BPPV in patients with ISSNHL may have no influence on hearing recovery. OBJECTIVES: BPPV occurs in 8.6-12.7% of patients with ISSNHL; however, the role of BPPV in hearing recovery remains controversial. Therefore, we investigated hearing outcomes in the patients, including the distribution of initial hearing threshold, the type of canal involved, and the number of repositioning maneuvers performed. METHODS: Of 241 patients with ISSNHL who presented to a dizziness clinic between March 2008 and May 2012, 13 with both ISSNHL and BPPV were recruited for this study. The patients were evaluated for their initial hearing threshold, type of canal involved, response to repositioning maneuvers, and hearing outcome. Age- and hearing threshold-matched patients with ISSNHL but without BPPV were randomly sampled and included for a hearing outcome comparison. RESULTS: Of 13 patients with ISSNHL and BPPV, 11 showed profound hearing loss. The lateral canal was involved in 11 patients, including 3 who had multi-canal involvement. Ten patients underwent a single repositioning maneuver. Those patients did not display a significant difference in hearing recovery compared with those patients having ISSNHL only.

Hong SM; Yeo SG

2013-05-01

153

Sudden bilateral sensorineural hearing loss associated with urticarial vasculitis.  

UK PubMed Central (United Kingdom)

BACKGROUND: Bilateral sensorineural hearing loss associated with recurrent urticarial skin lesions may be signs of underlying Muckle-Wells syndrome. Previous reports have described the hearing loss to be progressive in nature. METHOD: To our knowledge, this paper presents the first published case of sudden onset, bilateral sensorineural hearing loss associated with urticarial vasculitis due to underlying Muckle-Wells syndrome. RESULTS: The patient underwent a cochlear implantation with a modest outcome. CONCLUSION: Cochlear implantation may help to rehabilitate sudden hearing loss associated with this condition, but early diagnosis may allow treatment with interleukin-1? inhibitors such as anakinra.

Hall AC; Leong AC; Jiang D; Fitzgerald-O'Connor A

2013-07-01

154

Children with sensorineural hearing loss after passing the newborn hearing screen.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To identify and describe the findings of children who passed their newborn hearing screen (NHS) and were subsequently found to have childhood hearing loss. SETTING: Academic tertiary care center. DESIGN: Retrospective medical chart review. METHODS: With approval of the institutional review board, hospital records were reviewed for children diagnosed as having hearing loss. We identified 923 children with hearing loss from 2001 to 2011. Patients who passed the NHS with subsequent hearing loss were included. RESULTS: Seventy-eight patients were included in our study. The suspicion of hearing loss in patients who passed the NHS was most often from parental concerns (n = 28 [36%]) and failed school hearing screens (n = 25 [32%]). Speech and language delay and failed primary care physician screens accounted for 17% and 12%, respectively. Configuration of the audiogram was bilateral symmetric (n = 42 [54%]), bilateral asymmetric (n = 16 [21%]), and unilateral (n = 20 [26%]) loss. Thirty-seven patients (47%) had severe or profound hearing loss. The etiology was unknown in 42 patients (54%); the remaining was attributed to genetics (n = 13 [17%]), anatomic abnormality (n = 11 [14%]), acquired perinatal (n = 9 [12%]), and auditory neuropathy (n = 3 [4%]). CONCLUSIONS: This is the largest study to characterize children with hearing loss who passed the NHS. In our review, parental concerns and school hearing screens were the most common method to diagnose hearing loss after passing the NHS. Families and primary care physicians may have a false sense of security when patients pass the NHS and overlook symptoms of hearing loss. This study raises the question whether further screens would identify hearing loss in children after passing the NHS.

Dedhia K; Kitsko D; Sabo D; Chi DH

2013-02-01

155

Hyperbaric oxygen therapy for sudden sensorineural hearing loss in large vestibular aqueduct syndrome.  

UK PubMed Central (United Kingdom)

Introduction: We report the first use in Australia of hyperbaric oxygen therapy for sudden hearing loss following head trauma in a child with large vestibular aqueduct syndrome. Case report: A 12-year-old boy with large vestibular aqueduct syndrome presented with significant hearing loss following head trauma. He was treated with steroids and hyperbaric oxygen therapy, with good improvement of hearing thresholds on audiography. This case represents the first reported use of hyperbaric oxygen therapy for this indication in Australia, following a few previous reports of patients in Japan. We review the literature on management of acute sensorineural hearing loss in large vestibular aqueduct syndrome. The reported case demonstrates a potentially beneficial therapy for a rare condition that usually results in an inevitable decline in hearing. Conclusion: Hyperbaric oxygen therapy can be tolerated well by children, and may represent a potential treatment for sudden sensorineural hearing loss in patients with large vestibular aqueduct syndrome.

Shilton H; Hodgson M; Burgess G

2013-06-01

156

Hyperbaric oxygen therapy for sudden sensorineural hearing loss in large vestibular aqueduct syndrome.  

Science.gov (United States)

Introduction: We report the first use in Australia of hyperbaric oxygen therapy for sudden hearing loss following head trauma in a child with large vestibular aqueduct syndrome. Case report: A 12-year-old boy with large vestibular aqueduct syndrome presented with significant hearing loss following head trauma. He was treated with steroids and hyperbaric oxygen therapy, with good improvement of hearing thresholds on audiography. This case represents the first reported use of hyperbaric oxygen therapy for this indication in Australia, following a few previous reports of patients in Japan. We review the literature on management of acute sensorineural hearing loss in large vestibular aqueduct syndrome. The reported case demonstrates a potentially beneficial therapy for a rare condition that usually results in an inevitable decline in hearing. Conclusion: Hyperbaric oxygen therapy can be tolerated well by children, and may represent a potential treatment for sudden sensorineural hearing loss in patients with large vestibular aqueduct syndrome. PMID:23739031

Shilton, H; Hodgson, M; Burgess, G

2013-06-01

157

Improved Horizontal Directional Hearing in Bone Conduction Device Users with Acquired Unilateral Conductive Hearing Loss  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We examined horizontal directional hearing in patients with acquired severe unilateral conductive hearing loss (UCHL). All patients (n?=?12) had been fitted with a bone conduction device (BCD) to restore bilateral hearing. The patients were tested in the unaided (monaural) and aided (binaural) heari...

Agterberg, Martijn J. H.; Snik, Ad F. M.; Hol, Myrthe K. S.; van Esch, Thamar E. M.; Cremers, Cor W. R. J.; Van Wanrooij, Marc M.

158

Vocalizations of infants with hearing loss compared with infants with normal hearing: Part II--transition to words.  

UK PubMed Central (United Kingdom)

OBJECTIVE: By 24 mo of age, most typically developing infants with normal hearing successfully transition to the production of words that can be understood about 50% of the time. This study compares early phonological development in children with and without hearing loss to gain a clearer understanding of the effects of hearing loss in early-identified children. A secondary goal was to identify measures of early phonetic development that are predictors of later speech production outcomes. DESIGN: The vocalizations and early words of 21 infants with normal hearing and 12 early-identified infants with hearing loss were followed longitudinally over a period of 14 mo (from 10 to 24 mo of age). Thirty-minute mother-child interaction samples were video recorded at 6- to 8-wk intervals in a laboratory playroom setting. Vocalizations produced at 16 and 24 mo were categorized according to communicative intent and recognizable words versus other types. Groups were compared on the structural complexity of words produced at 24 mo of age. Parent report measures of vocabulary development were collected from 10 to 30 mo of age, and Goldman-Fristoe Test of Articulation scores at 36 mo were used in regression analyses. RESULTS: Both groups increased the purposeful use of voice between 16 and 24 mo of age. However, at 24 mo of age, the toddlers with hearing loss produced significantly fewer words that could be recognized by their mothers. Their samples were dominated by unintelligible communicative attempts at this age. In contrast, the samples from normal hearing children were dominated by words and phrases. At 24 mo of age, toddlers with normal hearing were more advanced than those with hearing loss on seven measures of the structural complexity of words. The children with normal hearing attempted more complex words and productions were more accurate than those of children with hearing loss. At 10 to 16 mo of age, the groups did not differ significantly on parent-report measures of receptive vocabulary. However, the hearing loss group was much slower to develop expressive vocabulary and demonstrated larger individual differences than the normal hearing group. Six children identified as atypical differed from all other children in vowel accuracy and complexity of word attempts. However, both atypical infants and typical infants with hearing loss were significantly less accurate than normal hearing infants in consonant and word production. Early measures of syllable production predicted unique variance in later speech production and vocabulary outcomes. CONCLUSIONS: The transition from babble to words in infants with hearing loss appears to be delayed but parallel to that of infants with normal hearing. These delays appear to exert significant influences on expressive vocabulary development. Parents may appreciate knowing that some children with hearing loss may develop early vocabulary at a slower rate than children with normal hearing. Clinicians should monitor landmarks from babble onset through transitions to words. Indicators of atypical development were delayed and/or limited use of syllables with consonants, vowel errors and limited production of recognizable words.

Moeller MP; Hoover B; Putman C; Arbataitis K; Bohnenkamp G; Peterson B; Lewis D; Estee S; Pittman A; Stelmachowicz P

2007-09-01

159

Understanding excessive SNR loss in hearing-impaired listeners.  

UK PubMed Central (United Kingdom)

BACKGROUND: Traditional audiometric measures, such as pure-tone thresholds or unaided word-recognition in quiet, appear to be of marginal use in predicting speech understanding by hearing-impaired (HI) individuals in background noise with or without amplification. Suprathreshold measures of auditory function (tolerance of noise, temporal and frequency resolution) appear to contribute more to success with amplification and may describe more effectively the distortion component of hearing. However, these measures are not typically measured clinically. When combined with measures of audibility, suprathreshold measures of auditory distortion may provide a much more complete understanding of speech deficits in noise by HI individuals. PURPOSE: The primary goal of this study was to investigate the relationship among measures of speech recognition in noise, frequency selectivity, temporal acuity, modulation masking release, and informational masking in adult and elderly patients with sensorineural hearing loss to determine whether peripheral distortion for suprathreshold sounds contributes to the varied outcomes experienced by patients with sensorineural hearing loss listening to speech in noise. RESEARCH DESIGN: A correlational study. STUDY SAMPLE: Twenty-seven patients with sensorineural hearing loss and four adults with normal hearing were enrolled in the study. DATA COLLECTION AND ANALYSIS: The data were collected in a sound attenuated test booth. For speech testing, subjects' verbal responses were scored by the experimenter and entered into a custom computer program. For frequency selectivity and temporal acuity measures, subject responses were recorded via a touch screen. Simple correlation, step-wise multiple linear regression analyses and a repeated analysis of variance were performed. RESULTS: Results showed that the signal-to-noise ratio (SNR) loss could only be partially predicted by a listener's thresholds or audibility measures such as the Speech Intelligibility Index (SII). Correlations between SII and SNR loss were higher using the Hearing-in-Noise Test (HINT) than the Quick Speech-in-Noise test (QSIN) with the SII accounting for 71% of the variance in SNR loss for the HINT but only 49% for the QSIN. However, listener age and the addition of suprathreshold measures improved the prediction of SNR loss using the QSIN, accounting for nearly 71% of the variance. CONCLUSIONS: Two standard clinical speech-in-noise tests, QSIN and HINT, were used in this study to obtain a measure of SNR loss. When administered clinically, the QSIN appears to be less redundant with hearing thresholds than the HINT and is a better indicator of a patient's suprathreshold deficit and its impact on understanding speech in noise. Additional factors related to aging, spectral resolution, and, to a lesser extent, temporal resolution improved the ability to predict SNR loss measured with the QSIN. For the HINT, a listener's audibility and age were the only two significant factors. For both QSIN and HINT, roughly 25-30% of the variance in individual differences in SNR loss (i.e., the dB difference in SNR between an individual HI listener and a control group of NH listeners at a specified performance level, usually 50% word or sentence recognition) remained unexplained, suggesting the need for additional measures of suprathreshold acuity (e.g., sensitivity to temporal fine structure) or cognitive function (e.g., memory and attention) to further improve the ability to understand individual variability in SNR loss.

Grant KW; Walden TC

2013-04-01

160

Progressive visual and hearing loss secondary to neurosyphilis.  

UK PubMed Central (United Kingdom)

PURPOSE: There is a rising incidence of syphilis in economically advanced countries. Early diagnosis can spare the patient devastating vision and hearing loss, as well as other significant morbidity. Ocular presentations of neurosyphilis are varied and numerous, requiring syphilis to be considered in many clinical situations, even if a negative medical history is reported. Features of Argyll Robertson pupils, however, are virtually pathognomonic of syphilis; therefore, careful pupil testing can be the key to making a correct and timely diagnosis. CASE REPORT: A 51-year-old woman with a history of unexplained hearing loss presented for a third opinion for progressive vision loss OU, which was previously labeled as functional loss. A review of records indicated significant worsening of visual acuity and visual fields over 6 months, with minimal remaining visual function. She exhibited features of optic neuropathy as well as 2 mm miotic pupils, with evident light-near dissociation bilaterally. Evaluation showed a reactive fluorescent treponemal antibody absorption and rapid plasma reagin (1:8 titer) and positive cerebral spinal fluid venereal disease research laboratory test. A diagnosis of neurosyphilis was made, and a 2-week course of intravenous penicillin treatment was completed. Despite treatment, her vision decreased to no light perception OU owing to the advanced course of the disease at the time of treatment. CONCLUSIONS: Neurosyphilis can occur at any stage of infection and needs to be considered in the differential diagnosis for many visual and ocular problems, especially in the setting of other systemic signs and symptoms. In this case, the combination of light-near dissociation and optic neuropathy with hearing loss was instrumental in dismissing the past diagnosis of functional vision loss and in pursuing the diagnosis of neurosyphilis. A timely diagnosis of neurosyphilis needs to be made to prevent devastating vision loss as seen in this case.

Draper EM; Malloy KA

2012-11-01

 
 
 
 
161

Working memory, age, and hearing loss: susceptibility to hearing aid distortion.  

UK PubMed Central (United Kingdom)

OBJECTIVES: Hearing aids use complex processing intended to improve speech recognition. Although many listeners benefit from such processing, it can also introduce distortion that offsets or cancels intended benefits for some individuals. The purpose of the present study was to determine the effects of cognitive ability (working memory) on individual listeners' responses to distortion caused by frequency compression applied to noisy speech. DESIGN: The present study analyzed a large data set of intelligibility scores for frequency-compressed speech presented in quiet and at a range of signal-to-babble ratios. The intelligibility data set was based on scores from 26 adults with hearing loss with ages ranging from 62 to 92 years. The listeners were grouped based on working memory ability. The amount of signal modification (distortion) caused by frequency compression and noise was measured using a sound quality metric. Analysis of variance and hierarchical linear modeling were used to identify meaningful differences between subject groups as a function of signal distortion caused by frequency compression and noise. RESULTS: Working memory was a significant factor in listeners' intelligibility of sentences presented in babble noise and processed with frequency compression based on sinusoidal modeling. At maximum signal modification (caused by both frequency compression and babble noise), the factor of working memory (when controlling for age and hearing loss) accounted for 29.3% of the variance in intelligibility scores. Combining working memory, age, and hearing loss accounted for a total of 47.5% of the variability in intelligibility scores. Furthermore, as the total amount of signal distortion increased, listeners with higher working memory performed better on the intelligibility task than listeners with lower working memory did. CONCLUSIONS: Working memory is a significant factor in listeners' responses to total signal distortion caused by cumulative effects of babble noise and frequency compression implemented with sinusoidal modeling. These results, together with other studies focused on wide-dynamic range compression, suggest that older listeners with hearing loss and poor working memory are more susceptible to distortions caused by at least some types of hearing aid signal-processing algorithms and by noise, and that this increased susceptibility should be considered in the hearing aid fitting process.

Arehart KH; Souza P; Baca R; Kates JM

2013-05-01

162

Disacusia neurossensorial imunomediada Immunomediated sensorineural hearing loss  

Directory of Open Access Journals (Sweden)

Full Text Available A disacusia neurossensorial imunomediada (DNSI) é caracterizada geralmente por uma disacusia neurossensorial bilateral, progressiva e assimétrica, acompanhada ou não por outros sintomas da orelha interna. Três pacientes com DNSI cujo quadro clínico e audiométrico eram sugestivos de doença auto-imune, e apresentaram resposta positiva à terapia imunossupressora ou pesquisa positiva de anticorpo anti hsp-70 68kD, foram estudados com relação às características clínicas, testes diagnósticos, alternativas terapêuticas e evolução da doença. Dois pacientes apresentaram quadro de disacusia neurossensorial rapidamente progressiva, associado a quadro vestibular, e outro, quadro de surdez súbita unilateral. Nenhum paciente apresentou positividade às provas reumatológicas, e apenas um paciente apresentou aumento na velocidade de hemossedimentação. Nenhum paciente obteve resposta adequada sustentada à corticoterapia, mas dois deles melhoraram com outras terapias imunossupressoras. O diagnóstico da DNSI é clínico e baseado na resposta positiva ao teste terapêutico com imunossupressores. A pesquisa de anticorpo anti-hsp70 de 68 kD pelo Western Blot é o único exame laboratorial específico para seu diagnóstico, possuindo sensibilidade de 42% e especificidade de 90%. Apenas 1 paciente apresentou positividade para este teste e não respondeu à terapia imunossupressora. Os dois pacientes com teste negativo responderam satisfatoriamente ao tratamento. A baixa sensibilidade do Western Blot e seu alto custo dificultam sua difusa utilização em nosso meio. A introdução precoce do tratamento é de suma importância por auxiliar no diagnóstico e por proporcionar um melhor prognóstico auditivo.The immunomediated sensorineural hearing loss (ISHL) is characterized as an asymmetric and progressive sensorineural hearing loss. Tree patients with ISHL were studied, regarding clinical aspects, diagnostic tests, treatment options and disease evolution. They presented whether positive response to immunosuppressive therapy or positiviness to Western Blot test for hsp 70-68kD. Two patients presented rapidly progressive sensorineural hearing loss, associated to vestibular symptoms and the other presented unilateral sudden deafness. No patient reacted to rheumatological testes, and one presented increased erythrocyte sedimentation rate. None satisfactorily responded to corticotherapy, but two presented clinical improvement with other immunosuppressive therapies. The ISHL diagnosis is based on clinical aspects and on the positive response to therapeutic testes with immunosupressor drugs. The Western Blot test for hsp 70-68 kD, with 42% sensitivity and 90% specificity, is the only specific laboratorial exam for ISHL. One patient presented positiviness to this exam and did not responded to immunosuppressive therapy. Two patients with negative tests satisfactorily responded to immunosuppressive therapy. The low sensitivity and high costs of Western Blot test represent difficulties to the spread use of it. The early introduction of treatment has a major importance in the diagnosis of ISHL and to increase the auditory prognosis.

Norma de Oliveira Penido; Mariana Dantas Aumond; Fernando Danelon Leonhardt; Carlos Eduardo Cesário de Abreu; Ronaldo Nunes Toledo

2002-01-01

163

Age-Related Hearing Loss and the Factors Determining Continued Usage of Hearing Aids among Elderly Community-Dwelling Residents  

Science.gov (United States)

While hearing aids are recommended for people with age-related hearing loss, many with impaired hearing do not use them. In this study, we investigated how many elderly people in the study area needed hearing aids, and the factors that determined continued wearing of the devices. The study area was Kurabuchi Town, Japan, where 1,437 residents (those aged 65 years or over) were eligible for participation in the study; 1,414 participated, of whom, 103 (7.3%) were already using hearing aids at the start of the study. After the primary screening, hearing aids were lent to 68 participants (4.8%) who did not already have one, 38 of whom (60.3% of the borrowers, representing 2.7% of the total aged population) went on to wear the hearing aid continuously. The Hearing Handicap Inventory for the Elderly (HHIE) score was significantly elevated among these 38 participants. This study indicated that hearing aids are of potential benefit to many local residents. Multivariate logistic regression revealed that HHIE scores were associated with the extent of HA usage. The adjusted odds ratio for a 1-unit increase in HHIE score was 1.08 (95% confidence interval: 1.02–1.14). Programs like this, in which people with impaired hearing are identified at the local level and given appropriate assistance, are useful models for future use in societies with aging populations.

Michikawa, Takehiro; Saito, Hideyuki; Okamoto, Yasuhide; Enomoto, Chieko; Takebayashi, Toru; Ogawa, Kaoru

2013-01-01

164

Contributing Factors in Inducing Noise Induced Hearing Loss  

Directory of Open Access Journals (Sweden)

Full Text Available The most common contributing factors in inducing hearing loss in adults are aging, exposure to noise and the interaction among these factors with other parameters. Individual parameters are also effective in the extent of hearing loss which is produced. Being aware of Vulnerability factors such as physical parameters, Auditory and non-auditory factors can be useful in considering a good hearing conservation program for noise induced hearing losses.In the current article we are aimed at introducing three important parameters and their sub-divisions pertaining to this issue.

Saeid Farahani

1999-01-01

165

Moderate effects of hearing loss on mental health and subjective well-being: results from the Nord-Trondelag Hearing Loss Study.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To estimate effects of hearing loss on symptoms of anxiety, depression, self-esteem, and subjective well-being. METHODS: A normal population sample of 50,398 subjects, age 20 to 101 years, in Nord-Trøndelag completed audiometric tests and questionnaires. The association between hearing loss and mental health was assessed with multiple linear regression analyses, controlling for social background variables. RESULTS: Effects of hearing loss were mostly significant, but moderate in strength. Effects were stronger among young (20-44 years) and middle-aged (45-64 years) than among older (65+ years) people. Loss of high or middle frequency hearing had almost no impact on mental health measures if low frequency hearing was not also impaired. The strongest observed effect was a change of 0.1 SD in mental health per 10 dB hearing loss. CONCLUSIONS: Hearing loss is associated with substantially reduced mental health ratings among some young and middle-aged persons, but usually does not affect mental health much among older persons.

Tambs K

2004-09-01

166

Medication for hearing loss after fractionated stereotactic radiotherapy (SRT) for vestibular schwannoma  

International Nuclear Information System (INIS)

Purpose: To investigate the effectiveness of corticosteroid treatments for patients showing decreases in hearing levels after stereotactic radiotherapy for vestibular schwannoma. Methods and Materials: Twenty-one patients experienced a hearing loss in pure-tone average at greater than 20 dB or less than 10 dB within 1 year after irradiation administration of 44 Gy/22 fractions followed by a 4 Gy boost. Eight received oral prednisone at a daily dose of 30 mg, which was gradually decreased (medicated group), and 13 received none (nonmedicated group). The average observation period was 26.7±16.6 (range: 6-69) months. Results: Hearing recovery was seen after initial onset of the hearing loss in all 8 patients in the medicated group and in 2 of 13 patients in the nonmedicated group (p=0.001). The hearing recovery, that is, the change in pure-tone average (dB) at the last follow-up from the onset of hearing loss, was 9.8±6.9 dB (recovery) in the medicated group and -9.4±12.8 dB (further loss) in the nonmedicated group (p=0.0013). The hearing recovery rate, normalizing to the degree of the hearing loss before medication, was also significantly higher in the medicated group than in the nonmedicated group (p=0.0014). Conclusions: Corticosteroidal intake is suggested to be effective in improving hearing loss after stereotactic radiotherapy, at least in young patients having a useful pretreatment hearing level, if the treatment for hearing loss is administered immediately after the hearing loss is first detected.

2001-08-01

167

What are the audiometric frequencies affected are the responsible for the hearing complaint in the hearing loss for ototoxicity after the oncological treatment?  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: The neurosensory bilateral simetric hearing loss resulting of the oncological treatment is underestimated, because the patients has the hearing detection preserved, reporting complaints in determined situation, or the not comprehension of part of the message. Objective: Investigate which are the audiometric frequencies affected are the responsible by the presence of hearing complaints. Method: Prospective study evaluating 200 patients with cancer in the childhood out of the oncological treatment in at least 8 years, with average age to the diagnosis of 6,21 years (4,71). Was applied anamnesis to investigate the presence of hearing complaints and performed a tonal threshold audiometry. To check the association between the complaint and the hearing loss, was applied the Exact test of Fisher, with one error a=5%, the patients were split into: normal hearing, hearing loss in 8kHz, loss in 6-8 kHz, loss in 4-8 kHz, loss in 2-8 kHz and loss in < 1-8 kHz. Results: We found 125 patients with hearing loss, 10 presented hearing complaints. Between the patients with hearing loss, 16 presented loss only at 8kHz, and 1 with complaint; 22 with loss in 6-8 kHz, being 3 with complaint; 16 with loss in 4-8 kHz, from them 10 with complaint; 15 with loss 2-8 kHz, being 14 with complaint and 6 with loss in < 1-8 kHz all with complaints. There were a significant relationship between the loss and hearing complaint (p<0,001), when the frequency of 4 kHz was involved. Conclusion: The bigger the number of affected frequencies the bigger the occurrence of hearing complaint, most of all when the speech frequencies are involved, and the involvement of 4 kHz already determines the appearing of the complaints.

Liberman, Patricia Helena Pecora; Goffi-Gomez, M. Valeria Schmidt; Schultz, Christiane; Lopes, Luiz Fernando

2012-01-01

168

Contributing Factors in Inducing Noise Induced Hearing Loss  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The most common contributing factors in inducing hearing loss in adults are aging, exposure to noise and the interaction among these factors with other parameters. Individual parameters are also effective in the extent of hearing loss which is produced. Being aware of Vulnerability factors such as p...

Saeid Farahani

169

Larsen's syndrome with mixed-type hearing loss.  

UK PubMed Central (United Kingdom)

Mixed-type hearing loss is an extremely rare feature of Larsen's syndrome, a complex of symptoms characterized by multiple joint dislocation and "flat" faces. In this report, a patient with bilateral mixed-type hearing loss and Larsen's syndrome is presented.

Perçín EF; Perçín S; Sezgin I; Akbas AK

1994-01-01

170

Noise Induced Hearing Loss among School Band Directors.  

Science.gov (United States)

Reports on a study that examined noise-induced hearing loss (NIHL) among school band directors. Finds that 41 percent of band directors in the sample had characteristic NIHL curves indicating that their experience as band directors played a role in the hearing loss. Recommends further study into the causes of NIHL among school band directors. (LS)

Cutietta, Robert A.; And Others

1989-01-01

171

Current aspects of hearing loss from occupational and leisure noise  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Hearing loss from occupational and leisure noise numbers amongst the most frequent causes of an acquired sensorineural hearing loss. Here we present a review of up-to-date findings on the pathophysiology of acoustic injury to the inner ear, with special attention being paid to its molecular-biologic...

Plontke, S; Zenner, HP

172

The evaluation of hearing loss in children with celiac disease.  

UK PubMed Central (United Kingdom)

BACKGROUND AND AIMS: Celiac disease (CD) is an autoimmune enteropathy. The disease may be presented with extraintestinal manifestations including neurological findings. Epilepsy and ataxia are well known neurological disorders in CD. But there are very limited numbers of reports on sensory-neural hearing loss in CD in the literature. The aim of this study was to investigate the hearing functions in children with newly diagnosed CD. MATERIALS AND METHODS: Ninety-seven (194 ears) [56 girls, 41 boys (age range: 1.5-17 years)] newly diagnosed celiac disease patients and 85 sex and age-matched controls (170 ears) were included in this study. Hearing function was assessed by pure-tone audiometry, speech audiometry, tympanometry and otoacoustic emissions measurements. RESULTS: No significant difference were found between the patients and control groups measurements including the pure-tone audiometry, speech audiometry, tympanometry and otoacoustic emissions No significant difference was found for pure-tone audiometry, speech audiometry, tympanometry and otoacoustic emissions measurements in celiac patients according to the Marsh-Oberhuber classification (P>0.05). CONCLUSIONS: Our results showed that hearing functions of children with newly diagnosed CD were similar to healthy controls.

Bükülmez A; Dalgiç B; Gündüz B; Sari S; Bayazit YA; Kemalo?lu YK

2013-02-01

173

Living with Hearing and Vision Loss Due to Usher Syndrome  

Medline Plus

Full Text Available ... Usher Syndrome Having trouble with this video? Try one of these: Living with Hearing and Vision Loss ... Vision Loss Due to Usher Syndrome Video NARRATOR 1: A woman with short gray hair. NARRATOR 2: ...

174

Application of an implantable bone conduction hearing device to patients with unilateral sensorineural hearing loss.  

UK PubMed Central (United Kingdom)

This investigation, comprised of five studies, was undertaken to determine if individuals with newly acquired profound unilateral hearing losses would benefit from an implantable bone-conduction hearing device. The bone conductor was implanted on the side of the deaf ear at the time of translabyrinthine acoustic tumor resection. Two areas greatly affected by unilateral hearing loss, speech recognition in noise and sound localization, were examined. No improvement in aided performance could be documented in either area.

Weber BA; Roush J; McElveen JT Jr

1992-05-01

175

IGF-I deficiency and hearing loss: molecular clues and clinical implications.  

Science.gov (United States)

Sensorineural hearing loss is a clinical heterogeneous disorder and a significant health-care problem with tremendous socio-economic impact. According to WHO, "Over 5% of the world's population has disabling hearing loss -328 million adults and 32 million children-". In children, early hearing loss affects language acquisition. Hearing deficits are generally associated with the loss of the sensory "hair" cells and/or neurons caused by primary genetic defects or secondary to environmental factors including infections, noise and ototoxic drugs. Hearing loss cannot be reversed and currently the available treatment is limited to hearing aids and cochlear implants. Studies are being conducted to develop alternative treatments combining both preventive and reparative strategies. Human insulin like growth factor (IGF) I deficiency is a rare disease associated with hearing loss, poor growth rates and mental retardation (ORPHA73272, OMIM608747). Similarly, lgf1-/- mice are dwarfs with poor survival rates and congenital profound sensorineural deafness. IGF-I is known to be a neuroprotective agent that maintains cellular metabolism, activates growth, proliferation and differentiation, and limits cell death. Here we will discuss the basic mechanisms underlying IGF-I actions in the auditory system and their clinical implications to pursue novel treatments to ameliorate hearing loss. PMID:23957197

Varela-Nieto, Isabel; Murillo-Cuesta, Silvia; Rodríguez-de la Rosa, Lourdes; Lassatetta, Luis; Contreras, Julio

2013-07-01

176

IGF-I deficiency and hearing loss: molecular clues and clinical implications.  

UK PubMed Central (United Kingdom)

Sensorineural hearing loss is a clinical heterogeneous disorder and a significant health-care problem with tremendous socio-economic impact. According to WHO, "Over 5% of the world's population has disabling hearing loss -328 million adults and 32 million children-". In children, early hearing loss affects language acquisition. Hearing deficits are generally associated with the loss of the sensory "hair" cells and/or neurons caused by primary genetic defects or secondary to environmental factors including infections, noise and ototoxic drugs. Hearing loss cannot be reversed and currently the available treatment is limited to hearing aids and cochlear implants. Studies are being conducted to develop alternative treatments combining both preventive and reparative strategies. Human insulin like growth factor (IGF) I deficiency is a rare disease associated with hearing loss, poor growth rates and mental retardation (ORPHA73272, OMIM608747). Similarly, lgf1-/- mice are dwarfs with poor survival rates and congenital profound sensorineural deafness. IGF-I is known to be a neuroprotective agent that maintains cellular metabolism, activates growth, proliferation and differentiation, and limits cell death. Here we will discuss the basic mechanisms underlying IGF-I actions in the auditory system and their clinical implications to pursue novel treatments to ameliorate hearing loss.

Varela-Nieto I; Murillo-Cuesta S; Rodríguez-de la Rosa L; Lassatetta L; Contreras J

2013-07-01

177

Mechanisms of hearing loss in neurofibromatosis type 2.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Patients with neurofibromatosis type 2 (NF2) develop bilateral cochleovestibular schwannomas (CVSs) that cause binaural deafness in most individuals. Hearing loss occurs in an unpredictable manner and the underlying mechanisms are not known. To gain insight into the pathophysiologic basis for hearing loss in NF2, we performed a prospective cross-sectional study of untreated ears in NF2 patients. METHODS: One hundred consecutive NF2 patients in a prospective natural history study were included. Clinical and audiometric data were analyzed for treatment naïve ears. In addition to standard MR-imaging sequences, alterations in intralabyrinthine protein content were determined utilizing high resolution FLAIR, the presence of cochlear aperture obstruction was determined by examining 3D T2 sequences, and endolymphatic hydrops was identified on delayed post-contrast FLAIR sequences. RESULTS: Eighty-nine ears harboring 84 untreated CVSs in 56 consecutive NF2 patients (age 30 ± 16 years) were analyzed. Thirty-four (38%) ears had varying degrees of hearing loss. Elevated intralabyrinthine protein was identified in 70 (75%) ears by FLAIR MR-imaging and was strongly associated with the presence of hearing loss (32/34 hearing loss ears; 94%)(Fisher's exact test; P=?.005). Elevated intralabyrinthine protein was associated with the presence of CVS-associated cochlear aperture obstruction (64 of 67 ears with elevated protein; 96%)(Fisher's exact test; P<0.0001) in both normal and hearing loss ears. Elevated intralabyrinthine protein was not identified in ears without CVS (5 ears). While larger tumor size was associated with hearing loss (P=0.006), 16 hearing loss ears (47%) harbored CVSs less than 0.5 cm(3), including 14 ears (88%) with block of the cochlear aperture and elevated protein. DISCUSSION: These findings are consistent with a model in which hearing loss develops as a result of cochlear aperture obstruction and accumulation of intralabyrinthine protein. MRI based identification of elevated intralabyrinthine protein may help identify the ear at-risk for developing hearing loss.

Asthagiri AR; Vasquez RA; Butman JA; Wu T; Morgan K; Brewer CC; King K; Zalewski C; Kim HJ; Lonser RR

2012-01-01

178

High-frequency audiometry: a means for early diagnosis of noise-induced hearing loss.  

UK PubMed Central (United Kingdom)

Noise-induced hearing loss (NIHL), an irreversible disorder, is a common problem in industrial settings. Early diagnosis of NIHL can help prevent the progression of hearing loss, especially in speech frequencies. For early diagnosis of NIHL, audiometry is performed routinely in conventional frequencies. We designed this study to compare the effect of noise on high-frequency audiometry (HFA) and conventional audiometry. In a historical cohort study, we compared hearing threshold and prevalence of hearing loss in conventional and high frequencies of audiometry among textile workers divided into two groups: With and without exposure to noise more than 85 dB. The highest hearing threshold was observed at 4000 Hz, 6000 Hz and 16000 Hz in conventional right ear audiometry, conventional left ear audiometry and HFA in each ear, respectively. The hearing threshold was significantly higher at 16000 Hz compared to 4000. Hearing loss was more common in HFA than conventional audiometry. HFA is more sensitive to detect NIHL than conventional audiometry. It can be useful for early diagnosis of hearing sensitivity to noise, and thus preventing hearing loss in lower frequencies especially speech frequencies.

Mehrparvar AH; Mirmohammadi SJ; Ghoreyshi A; Mollasadeghi A; Loukzadeh Z

2011-11-01

179

Effectiveness of hyperbaric oxygen therapy in idiopathic sudden hearing loss.  

Science.gov (United States)

The aim of this study was to investigate the efficacy of hyperbaric oxygen (HBO) therapy in idiopathic sudden sensorineural hearing loss (ISSHL) by comparing hearing gain and improvement rate in patients who have been placed on both HBO and medical treatment (MT) (37 patients), and patients who have received MT only (17 patients). Both groups were compared with reference to pure tone average (PTA) and the number of patients who experienced hearing gain. Of 37 patients (40 ears) who received HBO + MT, 24 (60 per cent) experienced > or = 10 decibels (dB) improvement in PTA compared to 13 (76.4 per cent) of 17 patients who were placed on MT only. Inter- or intra-group comparison of age stratification ( or = 50 ages) did not produce significant differences in PTA and in the number of patients who experienced hearing gain. Although there are numerous studies showing efficacy of HBO therapy; this study did not reveal a trend in favour of HBO therapy. PMID:16762093

Satar, B; Hidir, Y; Yetiser, S

2006-06-09

180

Systemic steroid reduces long-term hearing loss in experimental pneumococcal meningitis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Sensorineural hearing loss is a common complication of pneumococcal meningitis. Treatment with corticosteroids reduces inflammatory response and may thereby reduce hearing loss. However, both experimental studies and clinical trials investigating the effect of corticosteroids on hearing loss have ge...

Worsøe, Lise; Brandt, Christian T; Lund, Søren Peter; Østergaard, Christian; Thomsen, Jens; Cayé-Thomasen, Per

 
 
 
 
181

Revalence of Hearing Loss and the Related Factors in BuAli Hospital  

Directory of Open Access Journals (Sweden)

Full Text Available Objective:Determining the prevalence of hearing loss and correlated factors in clients referring to audiology clinic of Buali hospital. Method and Material: This cross-sectional analytic-descriptive survery was carried out on six thousand and twenty ears of 3010 clients (1651 ,a;e amd 1359 female) in Audiology clinic of Buali hospital , during Sept 2000 to Sept 2001. Results: Hearing loss is the most common reason for referring the clients (20.5%). 1319 ears (21.9%) Showed sensorineural hearing impairment and conductive and mixed hearing loss are observed in 1059 (17.6%) and 234 (3.9%) ears, respectedly. Hearing loss degree most cases is mild (14%) in both ears. There is no significant difference between male and female hearing threshold means (p>0.05) ‘ but a significant difference between hearing thresholds is observed in terms of age (p<0.05). Audiogram configuration in most cases is flat (55.1%). Otoscopic examination reveals abnormal condition in 2333 ears (38.8%) . 37.2% of the studied cases have abnormal tympanogram mostly type B (15.9%). 2.2% of the clients wear hearing aid that mostly have B.T.E ones (1.5%). 6.2% of the clients , depends on their hearing impairment type and degree need rehabilitation services. Conclusion: The results are Valid only in the context of this study and it’s generaliztion needs further researches.

Majid Ashrafi; Mohammad Reza Fathololumi; Mahin Sedaei; Jamileh Fattahi; Shohreh Jalaei

2004-01-01

182

The evidence base for the application of contralateral bone anchored hearing aids in acquired unilateral sensorineural hearing loss in adults.  

UK PubMed Central (United Kingdom)

. Acquired unilateral sensorineural hearing loss reduces the ability to localize sounds and to discriminate in background noise. . Four controlled trials attempt to determine the benefit of contralateral bone anchored hearing aids over contralateral routing of signal (CROS) hearing aids and over the unaided condition. All found no significant improvement in auditory localization with either aid. Speech discrimination in noise and subjective questionnaire measures of auditory abilities showed an advantage for bone anchored hearing aid (BAHA) > CROS > unaided conditions. . All four studies have material shortfalls: (i) the BAHA was always trialled after the CROS aid; (ii) CROS aids were only trialled for 4 weeks; (iii) none used any measure of hearing handicap when selecting subjects; (iv) two studies have a bias in terms of patient selection; (v) all studies were underpowered (vi) double reporting of patients occurred. . There is a paucity of evidence to support the efficacy of BAHA in the treatment of acquired unilateral sensorineural hearing loss. Clinicians should proceed with caution and perhaps await a larger randomized trial. . It is perhaps only appropriate to insert a BAHA peg at the time of vestibular schwanoma tumour excision in patients with good preoperative hearing, as their hearing handicap increases most.

Baguley DM; Bird J; Humphriss RL; Prevost AT

2006-02-01

183

Comparison of Different Levels of Reading Comprehension between Hearing-Impaired Loss and Normal-Hearing Students  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Aim: Reading skill is one of the most important necessities of students' learning in everyday life. This skill is referred to the ability of comprehension, comment and conclusion from texts and receiving the meaning of the massage which is composed. Educational development in any student has a direct relation with the ability of the comprehension. This study is designed to investigate the effects of hearing loss on reading comprehension in hearing-impaired students compared to normal-hearing ones.Methods: Seventeen hearing-impaired students in 4th year of primary exceptional schools in Karaj, Robatkarim and Shahriyar, Iran, were enrolled in this cross-sectional study. Seventeen normal-hearing students were randomly selected from ordinary schools next to exceptional ones as control group. They were compared for different levels of reading comprehension using the international standard booklet (PIRLS 2001). Results: There was a significant difference in performance between hearing-impaired and normal- hearing students in different levels of reading comprehension (p<0.05).Conclusion: Hearing loss has negative effects on different levels of reading comprehension, so in exceptional centers, reconsideration in educational planning in order to direct education from memorizing to comprehension and deeper layers of learning seems necessary.

Azam Sharifi; Ali Asghar Kakojoibari; Mohammad Reza Sarmadi

2011-01-01

184

Sensorineural Hearing Loss in Pseudoexfoliation Syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} PURPOSE: To determine hearing thresholds at sound frequencies important for speech comprehension in subjects with ocular pseudoexfoliation (PXF) and to compare them with that of controls without PXF. METHODS: Eighty-three subjects with ocular PXF and 83 age and sex matched controls without PXF were enrolled in this case-control study. Pure tone audiometry (bone conduction) was performed at 1, 2 and 3 kilohertz (KHz) in all subjects. Thresholds were compared to an age and sex stratified standard (ISO7029) and between study groups. Hearing loss was defined as sum of tested hearing thresholds (HTL-1,2,3) lower than the ISO7029 standard median. RESULTS: The study included 60 male and 23 female subjects in each group. Hearing loss was present in 147 of 166 (88.6%) of examined ears in the case group vs 89 of 166 (53.6%) in the control group (P Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}

Shahin Yazdani; Adib Tousi; Mohammad Pakravan; Ali-Reza Faghihi

2008-01-01

185

Admittance tympanometry with 2-kHz probe tones in patients with low-frequency hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVES/HYPOTHESIS: To assess the reliability of admittance tympanometry with 2-kHz probe tones in diagnosing ears with endolymphatic hydrops in patients with low-frequency hearing loss. STUDY DESIGN: Case-control study. METHODS: Thirty-six Japanese patients with low-frequency hearing loss (including 21 with Mènière disease, three with delayed endolymphatic hydrops, and 12 with acute or repetitious low-frequency sensorineural hearing loss), 18 patients with other types of hearing loss, and 16 subjects with normal hearing were enrolled at University of Tokyo Hospital. We measured the width of the splitting peaks in the admittance tymapnometry with 2-kHz probe tones. RESULTS: Widths of the probe pressure corresponding to splitting peaks of admittance (Y) tympanometry were significantly greater in the ears with endolymphatic hydrops than in the ears without endolymphatic hydrops in patients with low-frequency hearing loss. Furthermore, the widths in the ears with endolymphatic hydrops were greater than those in ears with other types of hearing loss. Widths of >255 daPa were observed in 38% of ears with endolymphatic hydrops and low-frequency hearing loss and in 21% of ears with other types of hearing loss. CONCLUSIONS: The current study demonstrated that wide splitting peaks of Y tympanometry are more frequently observed in ears showing low-frequency hearing loss than in those with other types of hearing loss, indicating that Y tympanometry can be used to diagnose endolymphatic hydrops in daily practice.

Yasui T; Iwasaki S; Sugasawa K; Sakamoto T; Kashio A; Suzuki M; Kakigi A; Yamasoba T

2012-10-01

186

Progressive familial hearing loss in Muckle-Wells syndrome.  

UK PubMed Central (United Kingdom)

CONCLUSION: The age-dependent disease progression requires accelerating diagnosis of Muckle-Wells syndrome (MWS) in order to start treatment as early as possible. The most frequent, but not obligate symptoms are familial fatigue, hearing loss, and arthralgia. The design of further clinical trials should focus on hearing in order to document the long-term effect of anti-interleukin (IL)-1 drugs on hearing preservation. OBJECTIVES: This paper describes the otologic features of a genetically defined syndrome causing progressive hearing loss by cochlear degeneration. This is the first study reporting the pretreatment otologic presentation of a selected population with familial MWS. METHODS: A single-center cohort was examined by audiologic and neurotologic methods including pure tone audiograms, vestibular testing, and tinnitus questionnaire. The audiograms of members of the same family were compared to describe the family-specific risk of hearing loss progression. RESULTS: Nineteen patients (aged 3-72 years) belonging to four families with three different mutations of the NLRP3 gene were examined. Almost all patients (89%, 17/19) demonstrated bilateral sensorineural hearing loss. Hearing loss started in the high frequencies and led to profound deafness in the most severe cases. Even in cases of profound hearing loss the vestibular caloric reactivity was normal. Nearly half of the adults reported intermittent or permanent tinnitus.

Koitschev A; Gramlich K; Hansmann S; Benseler S; Plontke SK; Koitschev C; Koetter I; Kuemmerle-Deschner JB

2012-07-01

187

Disacusia neurossensorial imunomediada/ Immunomediated sensorineural hearing loss  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A disacusia neurossensorial imunomediada (DNSI) é caracterizada geralmente por uma disacusia neurossensorial bilateral, progressiva e assimétrica, acompanhada ou não por outros sintomas da orelha interna. Três pacientes com DNSI cujo quadro clínico e audiométrico eram sugestivos de doença auto-imune, e apresentaram resposta positiva à terapia imunossupressora ou pesquisa positiva de anticorpo anti hsp-70 68kD, foram estudados com relação às características cl? (more) ?nicas, testes diagnósticos, alternativas terapêuticas e evolução da doença. Dois pacientes apresentaram quadro de disacusia neurossensorial rapidamente progressiva, associado a quadro vestibular, e outro, quadro de surdez súbita unilateral. Nenhum paciente apresentou positividade às provas reumatológicas, e apenas um paciente apresentou aumento na velocidade de hemossedimentação. Nenhum paciente obteve resposta adequada sustentada à corticoterapia, mas dois deles melhoraram com outras terapias imunossupressoras. O diagnóstico da DNSI é clínico e baseado na resposta positiva ao teste terapêutico com imunossupressores. A pesquisa de anticorpo anti-hsp70 de 68 kD pelo Western Blot é o único exame laboratorial específico para seu diagnóstico, possuindo sensibilidade de 42% e especificidade de 90%. Apenas 1 paciente apresentou positividade para este teste e não respondeu à terapia imunossupressora. Os dois pacientes com teste negativo responderam satisfatoriamente ao tratamento. A baixa sensibilidade do Western Blot e seu alto custo dificultam sua difusa utilização em nosso meio. A introdução precoce do tratamento é de suma importância por auxiliar no diagnóstico e por proporcionar um melhor prognóstico auditivo. Abstract in english The immunomediated sensorineural hearing loss (ISHL) is characterized as an asymmetric and progressive sensorineural hearing loss. Tree patients with ISHL were studied, regarding clinical aspects, diagnostic tests, treatment options and disease evolution. They presented whether positive response to immunosuppressive therapy or positiviness to Western Blot test for hsp 70-68kD. Two patients presented rapidly progressive sensorineural hearing loss, associated to vestibular (more) symptoms and the other presented unilateral sudden deafness. No patient reacted to rheumatological testes, and one presented increased erythrocyte sedimentation rate. None satisfactorily responded to corticotherapy, but two presented clinical improvement with other immunosuppressive therapies. The ISHL diagnosis is based on clinical aspects and on the positive response to therapeutic testes with immunosupressor drugs. The Western Blot test for hsp 70-68 kD, with 42% sensitivity and 90% specificity, is the only specific laboratorial exam for ISHL. One patient presented positiviness to this exam and did not responded to immunosuppressive therapy. Two patients with negative tests satisfactorily responded to immunosuppressive therapy. The low sensitivity and high costs of Western Blot test represent difficulties to the spread use of it. The early introduction of treatment has a major importance in the diagnosis of ISHL and to increase the auditory prognosis.

Penido, Norma de Oliveira; Aumond, Mariana Dantas; Leonhardt, Fernando Danelon; Abreu, Carlos Eduardo Cesário de; Toledo, Ronaldo Nunes

2002-10-01

188

First Information Parents Receive After UNHS Detection of Their Baby’s Hearing Loss  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The first information parents receive after referral through Universal Newborn Hearing Screening (UNHS) has significant consequences for later care-related decisions they take and thus for the future of the child with a hearing loss. In this study, 11 interviews were conducted with a representative ...

Matthijs, Liesbeth; Loots, Gerrit; Mouvet, Kimberley; Van Herreweghe, Mieke; Hardonk, Stefan; Van Hove, Geert; Van Puyvelde, Martine

189

Sensorineural hearing loss after vibration: an animal model for evaluating prevention and treatment of inner ear hearing loss.  

UK PubMed Central (United Kingdom)

Sensorineural hearing loss following a variety of acoustic trauma, including middle ear surgery, is well known. Current literature, which points to the deleterious influence of noise on the inner ear during surgery, has yet to assess the influence of vibration generated by the burr. The purpose of the study reported here was to establish an animal model that mimics drilling and can be used to explore methods of hearing loss prevention and treatment. A specially developed electromagnetic vibrator was calibrated and used in 59 guinea pigs to induce hearing loss. Both young and old guinea pigs were used. The bony external ear canal of guinea pigs were exposed to vibration or sound of varying duration and intensity. The vibration of the temporal bone and noise level in the middle ear were measured. Electrocochleography was recorded to evaluate the hearing loss. Among the young animals, 90% developed a significant threshold shift (TS > 20 dB), when vibrated with 250 Hz at an intensity of 6.2 m/s2 for 15 min. An average of 42 dB TS was observed. With 10 min exposure 63% showed a TS. The older animals vibrated for 5 min developed the same TS (mean TS 34 dB) as the young animals when vibrated for 10 min. The vibration-induced TS showed no recovery within 3 days of observation. In the contralateral ear 4 out of 5 animals showed TS > 20 dB. When exposed to sound levels exceeding the vibration-generated sound in the middle ear (119 dB at 250 Hz) only 2 out of II animals (18%) showed TS. The frequency of TS and level of TS were significantly greater in the vibrated animals than in sound-only exposed animals (p < 0.01). The degree of vibration-induced TS in the present animal model could be controlled by vibration intensity and duration. The older animals were more susceptible to vibration-induced inner-ear damage than younger animals. This model will be used in further studies to find methods for prevention and treatment of hearing loss during ear surgery.

Zou J; Bretlau P; Pyykkö I; Starck J; Toppila E

2001-01-01

190

Sensorineural hearing loss after vibration: an animal model for evaluating prevention and treatment of inner ear hearing loss.  

Science.gov (United States)

Sensorineural hearing loss following a variety of acoustic trauma, including middle ear surgery, is well known. Current literature, which points to the deleterious influence of noise on the inner ear during surgery, has yet to assess the influence of vibration generated by the burr. The purpose of the study reported here was to establish an animal model that mimics drilling and can be used to explore methods of hearing loss prevention and treatment. A specially developed electromagnetic vibrator was calibrated and used in 59 guinea pigs to induce hearing loss. Both young and old guinea pigs were used. The bony external ear canal of guinea pigs were exposed to vibration or sound of varying duration and intensity. The vibration of the temporal bone and noise level in the middle ear were measured. Electrocochleography was recorded to evaluate the hearing loss. Among the young animals, 90% developed a significant threshold shift (TS > 20 dB), when vibrated with 250 Hz at an intensity of 6.2 m/s2 for 15 min. An average of 42 dB TS was observed. With 10 min exposure 63% showed a TS. The older animals vibrated for 5 min developed the same TS (mean TS 34 dB) as the young animals when vibrated for 10 min. The vibration-induced TS showed no recovery within 3 days of observation. In the contralateral ear 4 out of 5 animals showed TS > 20 dB. When exposed to sound levels exceeding the vibration-generated sound in the middle ear (119 dB at 250 Hz) only 2 out of II animals (18%) showed TS. The frequency of TS and level of TS were significantly greater in the vibrated animals than in sound-only exposed animals (p < 0.01). The degree of vibration-induced TS in the present animal model could be controlled by vibration intensity and duration. The older animals were more susceptible to vibration-induced inner-ear damage than younger animals. This model will be used in further studies to find methods for prevention and treatment of hearing loss during ear surgery. PMID:11349766

Zou, J; Bretlau, P; Pyykkö, I; Starck, J; Toppila, E

2001-01-01

191

[A clinical report of luetic hearing loss (author's transl)  

UK PubMed Central (United Kingdom)

Three patients with syphilitic hearing losses are reported. In these patients, the impairment of cochleovestibular function progressed rapidly and quite often with fluctuations. The prognosis of inner ear damage is generally poor. However, in one 24-year old patient, treatment with penicillin and cortisone was successful in arresting hearing loss. This loss began early in the second stage of the disease so that its luetic origin could be recognized at the onset of the otological symptoms.

von Schulthess G

1978-11-01

192

Does choir singing cause noise-induced hearing loss?  

UK PubMed Central (United Kingdom)

Although health problems in musicians have been previously reported; not much is known about noise-induced hearing loss due to choir singing. However, there are data to show that peak levels of more than 110 dB SPL are produced in choir singing, and major parts of sound energy can be found below 1 kHz and even 500 Hz but not below 100 Hz. To find out about possible hearing loss due to professional choir singing, we measured the hearing threshold level of 62 choir singers in a large opera choir. Most publications about noise-induced hearing loss report that the high-frequency region is impaired most. However, in our study the low frequency region was affected most, when compared with normative data (especially ISO 7029). Control groups of women and men with normal auditory function did not show pure-tone hearing thresholds different from ISO 7029. The permanent threshold shifts at 250 Hz and above are most likely noise induced with choir singing as noise source. However, hearing losses at 125 Hz and possibly partial at 250 Hz are caused by some other effect. An (unproven) hypothesis is that singing might lead to increased endolymph pressure, and thus might cause hearing loss especially in the low-frequency region. Whether more choirs show similar hearing impairment and whether singing raises cerebrospinal fluid pressure will be the subject of further investigations.

Steurer M; Simak S; Denk DM; Kautzky M

1998-01-01

193

Auditory Impairment and the Onset of Disability and Handicap in Noise-Induced Hearing Loss.  

Science.gov (United States)

Subjects with mild degrees of noise induced hearing loss were studied to identify measurable characteristics of hearing that identify the points of onset of hearing disability (defined as difficulty in hearing speech in various circumstances) and of heari...

D. W. Robinson P. A. Wilkins N. J. Thyer J. F. Lawes

1984-01-01

194

Noncarboplatin-induced Sensorineural Hearing Loss in a Patient With an Intracranial Nongerminomatous Germ Cell Tumor.  

Science.gov (United States)

Treatment for intracranial germ cell tumors includes platinum-based chemotherapy and external beam radiation therapy, which are risk factors for hearing loss. In patients who experience significant sensorineural ototoxicity due to cochlear hair cell injury, dose reduction of chemotherapy may be necessary. This report describes an adolescent male, with excellent treatment response for an intracranial nongerminomatous germ cell tumor, who developed sensorineural hearing loss, which was central rather than cochlear in origin and unrelated to carboplatin. This patient highlights the need to carefully differentiate the type and etiology of sensorineural hearing loss in patients with brain tumors receiving ototoxic chemotherapy. PMID:23652864

Vitanza, Nicholas; Shaw, Theresa M; Gardner, Sharon L; Allen, Jeffrey C; Harter, David H; Karajannis, Matthias A

2013-05-01

195

Noncarboplatin-induced Sensorineural Hearing Loss in a Patient With an Intracranial Nongerminomatous Germ Cell Tumor.  

UK PubMed Central (United Kingdom)

Treatment for intracranial germ cell tumors includes platinum-based chemotherapy and external beam radiation therapy, which are risk factors for hearing loss. In patients who experience significant sensorineural ototoxicity due to cochlear hair cell injury, dose reduction of chemotherapy may be necessary. This report describes an adolescent male, with excellent treatment response for an intracranial nongerminomatous germ cell tumor, who developed sensorineural hearing loss, which was central rather than cochlear in origin and unrelated to carboplatin. This patient highlights the need to carefully differentiate the type and etiology of sensorineural hearing loss in patients with brain tumors receiving ototoxic chemotherapy.

Vitanza N; Shaw TM; Gardner SL; Allen JC; Harter DH; Karajannis MA

2013-05-01

196

Clinical study on unilateral hearing loss in children  

International Nuclear Information System (INIS)

A series of 60 children was studied (aged 0 to 10 years, 32 boys, 28 girls) with severe unilateral sensorineural hearing loss of unknown etiology. There were two peaks, at 0 and 6 years. In 19 children, hearing loss was identified during a conservative general health checkup for school or preschool children. In 21 children aged 0 years, 16 were suspected of hearing loss by newborn hearing screening. Temporal bone computed tomography scans were examined in 51 patients. Sixteen ears (31.4%) with hearing loss had inner ear and/or internal auditory canal abnormalities. In one patient, the anomaly was the presence of a bony wall dividing the internal auditory canal into two separate compartments associated with severe inner ear hypoplasia. Two patients had a common cavity. In one of these patients, the anomaly was revealed because of severe bacterial meningitis, and another was detected by newborn hearing screening. Six patients had a narrow internal auditory canal, 4 had a narrow internal auditory canal and hypoplastic cochlea, and 1 had a narrow internal auditory canal and cystic vestibule, and lateral semicircular canal dysplasia. Two patients had a cystic vestibule and lateral semicircular canal dysplasia. One case showed fluctuation of the hearing level in the contralateral ear with normal hearing during the observation period at an average of 20 months. The number of children whose unilateral hearing loss is detected early by newborn hearing screening has enormously increased. Strategies for follow-up, early intervention, and support for families are necessary for young children with unilateral hearing impairment. (author)

2007-01-01

197

Visceral adipose tissue is significantly associated with hearing thresholds in adult women.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Metabolic syndrome is a risk factor for age-related hearing impairment (ARHI). There are metabolic differences between abdominal adipose tissue present in subcutaneous and visceral areas. In this study, we investigated the association between abdominal fat composition, measured by computerized tomography (CT), and hearing thresholds. PATIENTS AND METHODS: We recruited 662 adults aged 40-82 years with normal or symmetrical sensorineural hearing loss who underwent fat measurement by CT. Linear regression models were used to address the association between risk factors, including abdominal fat composition, and average hearing levels at low and high frequencies. RESULTS: After adjusting for age, systemic disease and other variables, a positive association between visceral adipose tissue (VAT) area and average hearing threshold was observed in women. In men, there was no significant association between abdominal fat composition and hearing threshold. CONCLUSION: Our findings show an association between VAT and hearing impairment in women. A reduction in visceral adiposity may help to prevent hearing loss in women.

Kim TS; Park SW; Kim DY; Kim EB; Chung JW; So HS

2013-02-01

198

Internet access and use in adults with hearing loss.  

UK PubMed Central (United Kingdom)

BACKGROUND: The future rehabilitation of adults with hearing loss is likely to involve online tools used by individuals at home. Online tools could also be useful for people who are not seeking professional help for their hearing problems. Hearing impairment is a disability that increases with age, and increased age is still associated with reduced use of the Internet. Therefore, to continue the research on online audiological rehabilitative tools for people with hearing loss, it is important to determine if and to what extent adults with hearing loss use the Internet. OBJECTIVE: To evaluate the use of the Internet and email in a group of adults with hearing loss and to investigate if their use of Internet and email differed between genders, among different age groups, and how it compared with the general population in Sweden. METHODS: Questionnaires containing multiple-choice questions about Internet access, email use, and educational level were mailed to individuals with hearing loss, who were registered as patients at a hearing aid clinic. Out of the 269 invited participants, 158 returned a completed questionnaire, which was a response rate of 58.7%. RESULTS: The results showed that 60% (94/158) of the participants with hearing loss used computers and the Internet. The degree of hearing loss in the group of participants did not explain the level of Internet usage, while factors of age, gender, and education did (P<.001). More men than women used the Internet (OR 2.54, 95% CI 1.32-4.91, P<.001). Use of the Internet was higher in the youngest age group (25-64 years) compared to the oldest age group (75-96 years, P=.001). A higher usage of the Internet was observed in the participants with hearing loss, especially the elderly, when compared with the general population of Sweden (OR 1.74, 95% CI 1.23-3.17, P=.04). CONCLUSIONS: We conclude that the use of computers and the Internet overall is at least at the same level for people with hearing loss as for the general age-matched population in Sweden, but that this use is even higher in specific age groups. These results are important for the future work in developing and evaluating rehabilitative educational online tools for adults with hearing loss.

Thorén ES; Oberg M; Wänström G; Andersson G; Lunner T

2013-01-01

199

Does Unilateral Hearing Loss Lead To Learning Handicap?  

Directory of Open Access Journals (Sweden)

Full Text Available Hearing loss, even when limited to 1 ear, has been indicated as a handicap to communication and learning. Although this does not seem true based on my clinical impressions, there are no objective data available to evaluate, or even infer, what type of hearing loss can become a true handicap to overall academic achievement. Presented herein are findings that imply, although do not prove, the potential academic handicap of unilateral hearing loss. This study prospectively analyzed the audiologic and otologic screening tests in a university over a 9-year period. The University of Tokyo is one of the leading universities in Japan; the students examined undoubtedly had academic ability well above average, for the entrance examination is one of the most difficult to pass in Japan. The potential handicap to academic achievement caused by hearing impairment was evaluated by comparing the prevalence of hearing impairment among the study population.

Gita Movalleli

2000-01-01

200

Sensorineural hearing loss in Lassa fever: two case reports  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Introduction Lassa fever is an acute arena viral haemorrhagic fever with varied neurological sequelae. Sensorineural hearing loss is one of the rare complications which occur usually during the convalescent stage of the infection. Case presentation The cases of two female patients aged 19 and 43 years old, respectively, with clinical features suggestive of Lassa fever and confirmed by immunoserological/Lassa-virus-specific reverse transcriptase polymerase chain reaction are presented. Both patients developed severe sensorineural hearing loss at acute phases of the infections. Conclusion Sensorineural hearing loss from Lassa fever infections can occur in both acute and convalescent stages and is probably induced by an immune response.

Okokhere Peter O; Ibekwe Titus S; Akpede George O

2009-01-01

 
 
 
 
201

A Comparison of Different Murine Models for Cytomegalovirus-Induced Sensorineural Hearing Loss.  

Science.gov (United States)

OBJECTIVES/HYPOTHESIS: To compare three different inoculation techniques for the development of cytomegalovirus (CMV)-induced sensorineural hearing loss (SNHL) in a mouse model. STUDY DESIGN: A prospective experimental animal study. METHODS: BALB/c mice underwent inoculation using green fluorescent protein-expressing mouse cytomegalovirus (mCMV-GFP) via transtympanic (TT), intraperitoneal (IP), or intracranial (IC) routes. Control mice received an equal volume of saline. Hearing thresholds were measured using both distortion product otoacoustic emissions (DPOAE) and evoked auditory brainstem response studies (ABR). Cochleas were harvested for histological examination and cytocochleogram. RESULTS: No mice in the TT or IP groups showed significant hearing loss. All infected mice in the IC group showed significantly elevated ABR and DPOAE thresholds at 4 weeks of age. Ten mice (55%) had profound hearing loss (?80?dB) at 4 weeks of age, while the other eight mice (45%) initially showed moderate hearing loss (?20?dB), which progressed to profound hearing loss by 6 to 8 weeks. Asymmetric hearing loss was seen in 40% of the mice. Temporal bone histology showed diffuse loss of outer hair cells (OHC). Green fluorescent protein (GFP)-labeled virus was abundant in the spiral ganglion and adjacent to the scala tympani at the basal region of the cochlea at 7 days postinjection, and devoid of GFP labeling by 14 days postinfection. CONCLUSIONS: Intracerebral injection of mCMV preferentially causes mCMV-mediated hearing loss relative to IP or TT injections. These results are consistent with the hearing loss reported in human congenital infection and may have implications for understanding the pathophysiology of CMV-mediated labyrinthitis. LEVEL OF EVIDENCE: N/A. Laryngoscope, 2013. PMID:23616191

Wang, Yong; Patel, Rusha; Ren, Chongyu; Taggart, Michael G; Firpo, Matthew A; Schleiss, Mark R; Park, Albert H

2013-04-24

202

A Comparison of Different Murine Models for Cytomegalovirus-Induced Sensorineural Hearing Loss.  

UK PubMed Central (United Kingdom)

OBJECTIVES/HYPOTHESIS: To compare three different inoculation techniques for the development of cytomegalovirus (CMV)-induced sensorineural hearing loss (SNHL) in a mouse model. STUDY DESIGN: A prospective experimental animal study. METHODS: BALB/c mice underwent inoculation using green fluorescent protein-expressing mouse cytomegalovirus (mCMV-GFP) via transtympanic (TT), intraperitoneal (IP), or intracranial (IC) routes. Control mice received an equal volume of saline. Hearing thresholds were measured using both distortion product otoacoustic emissions (DPOAE) and evoked auditory brainstem response studies (ABR). Cochleas were harvested for histological examination and cytocochleogram. RESULTS: No mice in the TT or IP groups showed significant hearing loss. All infected mice in the IC group showed significantly elevated ABR and DPOAE thresholds at 4 weeks of age. Ten mice (55%) had profound hearing loss (?80?dB) at 4 weeks of age, while the other eight mice (45%) initially showed moderate hearing loss (?20?dB), which progressed to profound hearing loss by 6 to 8 weeks. Asymmetric hearing loss was seen in 40% of the mice. Temporal bone histology showed diffuse loss of outer hair cells (OHC). Green fluorescent protein (GFP)-labeled virus was abundant in the spiral ganglion and adjacent to the scala tympani at the basal region of the cochlea at 7 days postinjection, and devoid of GFP labeling by 14 days postinfection. CONCLUSIONS: Intracerebral injection of mCMV preferentially causes mCMV-mediated hearing loss relative to IP or TT injections. These results are consistent with the hearing loss reported in human congenital infection and may have implications for understanding the pathophysiology of CMV-mediated labyrinthitis. LEVEL OF EVIDENCE: N/A. Laryngoscope, 2013.

Wang Y; Patel R; Ren C; Taggart MG; Firpo MA; Schleiss MR; Park AH

2013-04-01

203

A Fanconi Anemias Pationt with Bilateral Totall Hearing Loss  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Fanconi anemia (FA) is an autosomal recessive genetic disorder wich characterized by progressive pancytopenia, multiple congenital anomalies, increased susceptibility to acute myelogenous leukemia and epithelial cancers specially in head and neck and GUT. Characteristic feature of FA include short stature, café-au-laitspots, small eyes, mental retardation, skeletal and ear anomalies.Case: A 23-year-old man who was a known case of FA since he was ten reffered to audiology clinic because of severe hearing loss. His initial diagnosis was pneumonia. Audilogic evaluation revealed bilateral profound hearing loss. Conclusion: One of the anomalies in FA are ear anomalies. These included conductive haering loss, external auditory canal stenosis and auricular malformation and progressive sensoryneural hearing loss. In this report external auditory canal and tympanic membrane were normal. The result of tympanometry were type An and audiometry were bilateral profound hearing loss that is a rare finding in FA patient.

Dr. Seyed Moosa Sadr Hoseyni; Shahnaz Alamdari; Dr. Azam Alamdari; Dr. Leila Mashali

2009-01-01

204

Genetics of hearing loss: focus on DFNA2  

Directory of Open Access Journals (Sweden)

Full Text Available Laura M Dominguez, Kelley M DodsonDepartment of Otolaryngology, Head and Neck Surgery, Virginia Commonwealth University, Richmond, VAAbstract: The purpose of this review is to assess the current literature on deafness nonsyndromic autosomal dominant 2 (DFNA2) hearing loss and the mutations linked to this disorder. Hearing impairment, particularly nonsyndromic hearing loss, affects multiple families across the world. After the identification of the DFNA2 locus on chromosome 1p34, multiple pathogenic mutations in two genes (GJB3 and KCNQ4) have been reported. The overwhelming majority of pathogenic mutations linked to this form of nonsyndromic hearing loss have been identified in the KCNQ4 gene encoding a voltage-gated potassium channel. It is believed that KCNQ4 channels are present in outer hair cells and possibly inner hair cells and the central auditory pathway. This form of hearing loss is both phenotypically and genetically heterogeneous and there are still DFNA2 pedigrees that have not been associated with changes in either GJB3 or KCNQ4, suggesting that a possible third gene exists at this locus. Further studies of the DFNA2 locus will lead to a better understanding of progressive hearing loss and provide a better means of early detection and treatment.Keywords: deafness nonsyndromic autosomal dominant 2, nonsyndromic deafness, genetic hearing loss, GJB3, KCNQ4

Dominguez LM; Dodson KM

2012-01-01

205

Evaluation of hearing loss in juvenile insulin dependent patients with diabetes mellitus.  

UK PubMed Central (United Kingdom)

BACKGROUND: Diabetes mellitus is one of the most important epidemics of our era. Complications of this disease are diverse and include retinopathy, nephropathy and neuropathy. This study has been designed to evaluate hearing loss patterns in young children suffering from IDDM and define risk factors for this complication. METHODS: This descriptive analytic study includes 200 youngsters divided into two groups: 100 patients in diabetic group and 100 healthy individual in control group. Hearing thresholds are determined in 250, 500, 1000, 2000, 4000 and 8000 Hz and metabolic controls are evaluated as average of one year HbA1C, dividing diabetic group into well control and poor control subgroups. RESULTS: Twenty one out of 100 patients in diabetic group showed significant hearing loss. Hearing loss is correlated with metabolic control, showing less loss in patients with HbA1C less than 7.5%. Results showed that hearing loss is not related to sex of patients but duration of disease (more or less than 5 years) affects degree of hearing loss in some frequencies. CONCLUSIONS: Hearing loss in children suffering from IDDM is sensorineural, bilateral and symmetrical and is related to the duration of disease and state of metabolic control (HbA1C).

Okhovat SA; Moaddab MH; Okhovat SH; Al-Azab AA; Saleh FA; Oshaghi S; Abdeyazdan Z

2011-02-01

206

Cochlear implantation in nontraditional candidates: preliminary results in adolescents with asymmetric hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Traditionally, children are cochlear implant (CI) candidates if bilateral severe to profound hearing loss is present and amplification benefit is limited. The current study investigated abilities of adolescents with asymmetric hearing loss (one ear with severe to profound hearing loss and better hearing contralaterally), where the poorer ear received a CI and the better ear maintained amplification. STUDY DESIGN: Within-subject case study. SETTING: Pediatric hospital, outpatient clinic. PATIENTS: Participants were 5 adolescents who had not met traditional CI candidacy because of one better hearing ear but did have 1 ear that met criteria and was implanted. All maintained hearing aid (HA) use in the contralateral ear. In the poorer ear, before implant, 3 participants had used amplification, and the other 2 had no HA experience. MAIN OUTCOME MEASURE: Participants were assessed in 3 listening conditions: HA alone, CI alone, and both devices together (bimodal) for speech recognition in quiet and noise and sound localization. RESULTS: Three participants had CI open-set speech recognition and significant bimodal improvement for speech recognition and localization compared with the HA or CI alone. Two participants had no CI speech recognition and limited bimodal improvement. CONCLUSION: Some adolescents with asymmetric hearing loss who are not typical CI candidates can benefit from a CI in the poorer ear, compared with a HA in the better ear alone. Additional study is needed to determine outcomes for this population, especially those who have early onset profound hearing loss in one ear and limited HA experience.

Cadieux JH; Firszt JB; Reeder RM

2013-04-01

207

Young people: taking few precautions against hearing loss in discotheques.  

UK PubMed Central (United Kingdom)

This study evaluated adolescents' music-listening risk and protective behaviors in discotheques. While frequently standing close to the loudspeakers, taking few breaks, and hardly using hearing-protection devices, many are at risk of developing permanent hearing loss. Assessing visiting mode may be a first and quick screener to identify adolescents at risk.

Vogel I; Brug J; van der Ploeg CP; Raat H

2010-05-01

208

Sudden-onset of hearing loss after a slap  

Directory of Open Access Journals (Sweden)

Full Text Available A 57-year old woman presented with acute bleeding from the left ear associated with reduced hearing and tinnitus. She also complained of redness and discomfort of her left eye; but there was no visual loss. A day before, she was slapped on the left side of her face. Previously, she did not have any hearing or visual problem.

Jaafar R; Mohamad I

2013-01-01

209

Low-cholesterol diet and antilipid therapy in managing tinnitus and hearing loss in patients with noise-induced hearing loss and hyperlipidemia.  

UK PubMed Central (United Kingdom)

The aim of our study was to outline the prevalence of hyperlipidemia in patients who had high-frequency hearing loss and tinnitus due to noise exposure. We investigated the role of a low-cholesterol diet and antihyperlipidemic therapy to alleviate the severity of tinnitus and possibly promote hearing gain after therapy in patients with acoustic trauma. Forty-two hyperlipidemic patients with subjective tinnitus and hearing loss due to noise exposure were enrolled for the study. We placed patients on a low-cholesterol diet or antihyperlipidemic therapy and followed them for up to 24 months; then we designated two groups as either "unresponsive" (n = 22; no response to either of the therapies and still experiencing hyperlipidemia) or "responsive" (n = 20; lower cholesterol or triglyceride levels). We then compared tinnitus scores and hearing levels in the two groups. The difference between tinnitus scores in the unresponsive and responsive groups and the change in tinnitus scores before and after therapy in the responsive group were significant. When we compared self-rated tinnitus severity results in two groups after therapy, we found the difference was significant (p < .05). The difference between average air-conduction thresholds at high frequencies after the treatment in the two groups was also significant. The incidence of hyperlipidemia is high among patients with noise-induced hearing loss, and significant improvement by way of lowered tinnitus intensity and higher frequencies in average hearing thresholds can be achieved after lowering the serum lipid level.

Sutbas A; Yetiser S; Satar B; Akcam T; Karahatay S; Saglam K

2007-01-01

210

Low-cholesterol diet and antilipid therapy in managing tinnitus and hearing loss in patients with noise-induced hearing loss and hyperlipidemia.  

Science.gov (United States)

The aim of our study was to outline the prevalence of hyperlipidemia in patients who had high-frequency hearing loss and tinnitus due to noise exposure. We investigated the role of a low-cholesterol diet and antihyperlipidemic therapy to alleviate the severity of tinnitus and possibly promote hearing gain after therapy in patients with acoustic trauma. Forty-two hyperlipidemic patients with subjective tinnitus and hearing loss due to noise exposure were enrolled for the study. We placed patients on a low-cholesterol diet or antihyperlipidemic therapy and followed them for up to 24 months; then we designated two groups as either "unresponsive" (n = 22; no response to either of the therapies and still experiencing hyperlipidemia) or "responsive" (n = 20; lower cholesterol or triglyceride levels). We then compared tinnitus scores and hearing levels in the two groups. The difference between tinnitus scores in the unresponsive and responsive groups and the change in tinnitus scores before and after therapy in the responsive group were significant. When we compared self-rated tinnitus severity results in two groups after therapy, we found the difference was significant (p < .05). The difference between average air-conduction thresholds at high frequencies after the treatment in the two groups was also significant. The incidence of hyperlipidemia is high among patients with noise-induced hearing loss, and significant improvement by way of lowered tinnitus intensity and higher frequencies in average hearing thresholds can be achieved after lowering the serum lipid level. PMID:18229794

Sutbas, Aziz; Yetiser, Sertac; Satar, Bulent; Akcam, Timur; Karahatay, Serdar; Saglam, Kenan

2007-01-01

211

Outcome of vibrant soundbridge middle ear implant in cantonese-speaking mixed hearing loss adults.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To investigate the aided benefits, speech recognition in quiet and in noise, change in hearing and subjective report of satisfaction on mixed hearing loss adults implanted with Vibrant Soundbridge (VSB) middle ear implant. METHODS: Eight Cantonese speaking adult patients with mixed hearing loss were enrolled in a single-subject, repeated measures prospective study design. Audiometric testing, including air and bone conduction and word recognition under sound-field were conducted before surgery. Device activation was arranged 8 weeks after operation. Audiometric testing was taken to evaluate the change in hearing. Patients were asked to wear the device and come back for fine tuning as needed. Outcome measurements were undertaken at 3 and 6 months after device activation. The outcome measures included sound-field thresholds, Cantonese Hearing in Noise Test (CHINT), Abbreviated Profile of Hearing Aid Benefit (APHAB) and International Outcome Inventory for Hearing Aids (IOI-HA). RESULTS: The application of the VSB improved the aided thresholds and improved speech intelligibility in quiet and noise without significant changes in hearing thresholds. CONCLUSION: VSB is considered as a safe, effective and reliable auditory rehabilitation option for Cantonese speaking adults with mixed hearing loss.

Yu JK; Tsang WS; Wong TK; Tong MC

2012-04-01

212

Efficient estimates of cochlear hearing loss parameters in individual listeners  

DEFF Research Database (Denmark)

It has been suggested that the level corresponding to the knee-point of the basilar membrane (BM) input/output (I/O) function can be used to estimate the amount of inner- and outer hair-cell loss (IHL, OHL) in listeners with a moderate cochlear hearing impairment Plack et al. (2004). According to Jepsen and Dau (2011) IHL + OHL = HLT [dB], where HLT stands for total hearing loss. Hence having estimates of the total hearing loss and OHC loss, one can estimate the IHL. In the present study, results from forward masking experiments based on temporal masking curves (TMC; Nelson et al., 2001) are presented and used to estimate the knee-point level and the compression ratio of the I/O function. A time-efficient paradigm based on the single-interval-up-down method (SIUD; Lecluyse and Meddis (2009)) was used. In contrast with previous studies, the present study used only on-frequency TMCs to derive estimates of the knee-point level. Further, it is explored whether it is possible to estimate the compression ratio using only on-frequency TMCs. 10 normal-hearing and 10 hearing-impaired listeners (with mild-to-moderate sensorineural hearing loss) were tested at 1, 2 and 4 kHz. The results showed a reasonable reliability and may be applicable to individualized hearing-aid fitting. © 2013 Acoustical Society of America.

Fereczkowski, Michal; Jepsen, Morten LØve

2013-01-01

213

Living with Hearing and Vision Loss Due to Usher Syndrome  

Medline Plus

Full Text Available ... Hearing and Vision Loss Due to Usher Syndrome Video NARRATOR 1: A woman with short gray hair. ... Peck has Usher Syndrome. In this series of videos, she tells her story about overcoming some of ...

214

Postnatal risk factors associated with hearing loss among high-risk preterm infants: tertiary center results from Turkey.  

UK PubMed Central (United Kingdom)

The aim of this study was to determine the postnatal risk factors associated with hearing loss as well as the prevalence of hearing loss among high-risk preterm infants in newborn hearing screening (NHS). We performed a retrospective study of high-risk preterm infants born with a gestational age ?32 weeks and/or a birth weight ?1,500 g. A NHS procedure was performed by automated auditory brainstem response (AABR) and automated evoked otoacoustic emission (TEOAE). Infants who failed TEOAE or AABR or both tests were referred to a tertiary audiology center for diagnosis confirmation and management. Postnatal risk factors associated with hearing loss were evaluated and compared for preterm infants with and without hearing loss. 1,360 high-risk preterm infants were assessed. Permanent hearing loss was found in 19 (1.4 %) infants. Multivariate analysis revealed that proven sepsis (p = 0.019), mechanical ventilation ?5 days (p = 0.024), loop diuretics (p = 0.001), patent ductus arteriosus ligation (p = 0.018) and operation for retinopathy of prematurity (ROP) (p = 0.034) were significant related factors for the hearing loss. This study showed a low prevalence of hearing loss and an association between operation for ROP and hearing loss in preterm infants, which has not been defined previously. Our results suggest that every neonatal intensive care unit should determine their own risk factors and take precautions to prevent hearing loss for these high-risk preterm infants.

Eras Z; Konukseven O; Aksoy HT; Canpolat FE; Genç A; Sakrucu ED; Develio?lu O; Dilmen U

2013-08-01

215

Automatic hearing loss detection system based on auditory brainstem response  

International Nuclear Information System (INIS)

Hearing loss is one of the pathologies with the highest prevalence in newborns. If it is not detected in time, it can affect the nervous system and cause problems in speech, language and cognitive development. The recommended methods for early detection are based on otoacoustic emissions (OAE) and/or auditory brainstem response (ABR). In this work, the design and implementation of an automated system based on ABR to detect hearing loss in newborns is presented. Preliminary evaluation in adults was satisfactory.

2007-01-01

216

Hearing loss and risk of early retirement. The HUNT study.  

UK PubMed Central (United Kingdom)

BACKGROUND: We explore the possible consequences of measured hearing impairment (HI) and perceived hearing difficulties for early retirement in a large population-based study. Furthermore, we study whether having a part-time position was associated with measured HI and perceived hearing difficulties in the same population. METHODS: This study included 25 740 persons from the Nord-Trøndelag Health Study (HUNT) aged 20-54 years at baseline in HUNT1 (1984-1986) who also participated in the follow up, HUNT2, including a hearing examination 11 years later. Logistic regression analysis was conducted for men and women separately and in two age strata. Effects of low-, middle- and high-frequency hearing levels were explored, adjusting for each other. Further adjustment was made for socio-economic class and general health in HUNT1. RESULTS: The risk of early retirement increased with degree of loss of low-frequency hearing in young and middle-aged men and middle-aged women. The middle-aged men and women experiencing hearing disability had an increased risk of early retirement. Degree of hearing level was not associated with part-time work, but in middle-aged men, awareness of having a hearing loss was associated with part-time employment. CONCLUSIONS: Degree of low-frequency hearing loss was associated with early retirement but not with part-time work. Perceived hearing disability increased the risk of early retirement in middle-aged men and women and also the risk of part-time work in middle-aged men.

Helvik AS; Krokstad S; Tambs K

2013-08-01

217

Predictors of hearing aid use time in children with mild-to-severe hearing loss.  

UK PubMed Central (United Kingdom)

PURPOSE: This study investigated predictors of hearing aid (HA) use time for children with mild-to-severe hearing loss (HL). Barriers to consistent HA use and reliability of parent report measures were also examined. METHOD: Participants included parents of 272 children with HL. Parents estimated the amount of time the child used HAs daily. Regression analysis examined the relationships among independent variables and HA use time. To determine parental accuracy of HA use time, datalogging from the HAs was compared to the parents' estimates. RESULTS: Longer HA use related to older age, poorer hearing, and higher maternal education. Parental consistency ratings revealed similar findings--younger children and children with milder HL wore HAs less consistently than older children and children with more severe HL. Parents' estimates and datalogging were significantly correlated; however, results suggested that parents overestimate the amount of time their children wear their HAs. CONCLUSION: Certain variables were significantly related to the amount of time children wore their HAs. Consistency rating scales provided insight into circumstances that were challenging for families. Use of both parent reports and datalogging may allow clinicians and researchers to obtain a general estimate of HA use time.

Walker EA; Spratford M; Moeller MP; Oleson J; Ou H; Roush P; Jacobs S

2013-01-01

218

Congenital cytomegalovirus infection in pediatric hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To compare the prevalence of congenital cytomegalovirus (CMV) infection in Washington State in children with hearing loss (HL) and the general population and to compare the characteristics of HL in children with and without congenital CMV infection. DESIGN: Matched case-control; case cohort. SETTING: Regional pediatric hospital, Washington State Department of Health (WSDOH). PATIENTS: Cases were children 4 years and older with HL born in Washington State. Control individuals matched for demographic characteristics were identified at random through the WSDOH. MAIN OUTCOME MEASURES: Congenital CMV status determined using quantitative polymerase chain reaction testing on newborn heel stick blood spots archived by the WSDOH. Audiologic data were used to characterize HL. RESULTS: Congenital CMV testing was performed for 222 matched cases and controls. Congenital CMV infection was detected in 1.4% of controls and in 9.9% of cases (odds ratio, 10.5; 95% confidence interval, 2.6-92.4). An estimated 8.9% of HL in children in Washington can be attributed to CMV infection. After inclusion of an additional 132 children with HL (for a total of 354 cases in the case cohort), we observed that children with congenital CMV had more severe HL (P < .001) and higher proportions of progressive (P = .02) and unilateral (P = .002) HL compared with children without congenital CMV infection. In the 35 children with congenital CMV infection, there was no relationship between neonatal CMV load and severity of HL. CONCLUSIONS: In Washington State, children with HL had a far higher prevalence of congenital CMV viremia than did the general pediatric population, and CMV infection seems to be responsible for an appreciable fraction of pediatric HL in Washington State.

Misono S; Sie KC; Weiss NS; Huang ML; Boeckh M; Norton SJ; Yueh B

2011-01-01

219

Annual rate of hearing loss falls after fractionated stereotactic irradiation for vestibular schwannoma  

International Nuclear Information System (INIS)

Purpose: The rate of hearing loss in a population before and after irradiation was investigated to determine the effect of irradiation on hearing impairment. Methods and materials: In 72 patients with vestibular schwannoma who received fractionated stereotactic irradiation from 1992 to 1999, 21 had had their hearing levels examined 3 months or more before the treatment. The mean time between the initial examination and treatment was 18.6 months (range: 3-89 months), and the mean time between treatment and the last follow-up was 24.2 months (12-69 months). Thirty-six to 50 Gy in 20-25 fractions over 5 to 6 weeks was given using an X-ray beam from a linear accelerator. Pure tone average (PTA) was measured using the mean hearing level at five frequencies, and the annual rate of hearing loss was defined as [(hearing loss in PTA(dB))/(follow-up period (months)x12)]. Results: The actual cumulative curve of decrease in tumor size of 2 mm or more was 38.3% at 2 years and 80.0% at 3 years. The mean of hearing loss in PTA was 11.6±10.3 dB (-1 to 35 dB) from the initial examination to the start of irradiation and 11.9±14.4 dB (-14 to 37 dB) from the start of irradiation to the last follow-up. The mean annual rates of hearing loss before irradiation and in the 1st, 2nd, 3rd and 4th years after irradiation were, respectively, 18.6, 11.2, 6.2, 5.1, and 5.0 dB/year. The annual rates of hearing loss in the 2nd year (P=0.025) and 3rd year (P=0.018) were significantly slower than the rate before irradiation. Conclusions: The mean annual rate of hearing loss was higher before irradiation than after irradiation, and hearing loss slowed rather than accelerated after irradiation. Although hearing loss after the treatment was usually permanent, fractionated stereotactic irradiation was suggested to be effective to lower the rate of hearing loss.

2001-01-01

220

The association between reduced GFR and hearing loss: a cross-sectional population-based study.  

UK PubMed Central (United Kingdom)

BACKGROUND: Chronic kidney disease (CKD) has long been associated with hearing loss in certain syndromes. Reported evidence to date has come from only small observational studies. We present the first community-based study to show an association between nonsyndromal CKD and hearing loss. STUDY DESIGN: Cross-sectional population-based study to examine the relationship between CKD and age-related hearing loss. SETTING & PARTICIPANTS: The Blue Mountains Hearing Study is a survey of age-related hearing loss conducted in 1997-2004; a total of 2,564 participants had audiometric testing and complete renal data. PREDICTOR OR FACTOR: Moderate CKD, defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2). OUTCOMES: Bilateral hearing loss, defined as average pure-tone threshold >25 dB for measurements at frequencies of 0.5, 1.0, 2.0, and 4.0 kHz. MEASUREMENTS: Baseline biochemistry tests, including serum creatinine, were performed. Pure-tone audiometry was performed in sound-treated booths. RESULTS: Moderate CKD was present in 513 of 2,564 participants. Of persons with moderate CKD, 279 (54.4%) had measured hearing loss compared with 581 (28.3%) with eGFR ?60 mL/min/1.73 m(2). Moderate CKD was independently associated with hearing loss (OR, 1.43; 95% CI, 1.10-1.84; P = 0.006) after adjusting for age; sex; noise exposure; education; diabetes, hypertension, and stroke histories; and smoking. Participants with eGFR <45 mL/min/1.73 m(2) had the highest prevalence of hearing loss (73%) compared with those with eGFR ?90 mL/min/1.73 m(2) (19%; multivariate adjusted OR, 2.4 [95% CI, 1.3-4.5]). Analyses were repeated after excluding participants reporting furosemide use (a known ototoxic agent); the association between moderate CKD and hearing loss remained significant (multivariate adjusted OR, 1.40 [95% CI, 1.08-1.83]; P = 0.01). LIMITATIONS: The present study is not longitudinal and does not permit causal inference from the observed associations. CONCLUSIONS: Moderate CKD per se was associated independently with hearing loss. Recognizing this link could lead to earlier hearing assessment with appropriate interventions to preserve the hearing of patients with CKD.

Vilayur E; Gopinath B; Harris DC; Burlutsky G; McMahon CM; Mitchell P

2010-10-01

 
 
 
 
221

G-CSF attenuates noise-induced hearing loss.  

UK PubMed Central (United Kingdom)

In this study, we investigated the effects of granulocyte colony-stimulating factor (G-CSF) for the treatment of noise-induced hearing loss (NIHL) in a guinea pig model. Forty guinea pigs were randomly divided into four groups: control, noise (white noise, 3h/d for 2 days at 115dB), noise+G-CSF (350?g/kg/d for 5 days), and noise+saline. Auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) were used to determine the hearing threshold and outer hair cell function, respectively, in each group. Cochlear morphology was examined to evaluate hair cell injury induced by intense noise exposure. Fourteen days after noise exposure, the noise+G-CSF group had a lower ABR value than the noise group (P<0.05) or the noise+saline group (P<0.01). At most frequencies, the DPOAE value of the noise+G-CSF group showed a significant rise (P<0.05) compared to the noise group or the noise+saline group. Neither the ABR value nor the DPOAE value differed between the noise group and the noise+saline group. The morphology of the phalloidin-stained organ of Corti was consistent with the functional measurements. In conclusion, G-CSF can preserve hearing in an experimental model of NIHL in guinea pigs, by preserving hair cells after intense noise exposure.

Shi ZT; Lin Y; Wu J; Wang RF; Mi WJ; Qiu JH

2013-07-01

222

Prevalence of Hearing Loss in Newborns Admitted to Neonatal Intensive Care Unit  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Hearing is essential for humans to communicate with one another. Early diagnosis of hearing loss and intervention in neonates and infants can reduce developmental problems. The aim of the present study was to assess the prevalence of hearing impairment in newborns admitted to a neonatal intensive care unit (NICU) and analyze the associated risk factors.   Materials and Methods: This cross-sectional study was conducted to assess the prevalence of hearing loss in neonates who were admitted to the NICU at Nemazee Hospital, Shiraz University of Medical Sciences between January 2006 and January 2007. Auditory function was examined using otoacoustic emission (OAE) followed by auditory brainstem response (ABR) tests. Relevant potential risk factors were considered and neonates with a family history of hearing loss and craniofacial abnormality were excluded. For statistical analysis logistic regression, the chi-squared test, and Fisher’s exact test were used.    Results: Among the 124 neonates included in the study, 17 (13.7%) showed hearing loss in the short term. There was a significant statistical relationship between gestational age of less than 36 weeks (P=0.013), antibiotic therapy (P= 0.033), oxygen therapy (P=0.04), and hearing loss. On the contrary, there was no significant relationship between hearing loss and use of a ventilator, or the presence of sepsis, hyperbilirubinemia, congenial heart disease, transient tachypnea of newborn, congenital pneumonia, or respiratory distress syndrome.  Conclusion: Auditory function in neonates who are admitted to a NICU, especially those treated with oxygenor antibiotics and those born prematurely, should be assessed during their stay in hospital. The importance of early diagnosis of hearing loss and intervention in these neonates and avoidance of any unnecessary oxygenor antibiotic therapy needs to be further promoted.

Shahnaz Pourarian; Bijan Khademi; Narjes Pishva; Ali Jamali

2012-01-01

223

Prevalence of noise-induced hearing loss in drivers  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Work-related hearing loss is one of the most common occupational illness progresses over the years of noise exposure associated with the work environment, may cause damage to undertake physical activity, the individual's physiological and mental besides causing hearing damage irreversible interfering with communication and quality of life. With high prevalence of male evaluates which is the second leading cause of hearing loss. Since there is no medical treatment for this type of hearing loss, it is evident the importance of preventive and conferences aimed at preserving hearing and health as a whole. Objective: To assess the prevalence of hearing loss in audiometry admission of drivers. Methods: Retrospective study. By 76 charts of professional drivers in leased transport companies. We analyzed data from specific interview and pure tone audiometry. Results: The prevalence of abnormal tests was 22.36% with the lowest thresholds for tritonal average of 3,000, 4,000 and 6,000 Hz. The higher the age, the higher thresholds. Conclusion: This study has highlighted the occurrence of hearing in the absence of complaints. Considering that PAIR is preventable, justifies the importance of coordinated and multidisciplinary involving not only health teams and safety, but also the institutions involved in preserving the health of workers, as the team SESMET, unions or prosecutors.

Andréa Cintra Lopes1, , , ,; Vanessa Guioto Otowiz2; Patrícia Monteiro de Barros Lopes3; José Roberto Pereira Lauris4; Cibele Carméllo Santos5

2012-01-01

224

[Tympanotomy and sealing of the round window membrane in sudden sensorineural hearing loss: a retrospective analysis].  

UK PubMed Central (United Kingdom)

BACKGROUND: The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSHL) still remains unclear. This retrospective study was performed to evaluate the effectiveness of tympanotomy and sealing of the round window membrane after unilateral idiopathic sudden sensorineural hearing loss. METHODS: A total of 74 patients with idiopathic sudden sensorineural hearing loss were treated with antiphlogistic-rheologic infusion therapy according to Stennert (steroids and pentoxyphylline). In addition, all patients underwent exploratory tympanotomy and sealing of the round window membrane. Pure tone audiometry was performed pre- and postinterventionally. RESULTS: The average hearing loss (four pure tone average) of all patients was 58.9 dB pre-, and 46 dB postinterventionally, which is an average improvement of 12.9 dB. Patients with hearing loss of more than 60% improved significantly compared to patients with hearing loss less than 60% (33.9% vs. +3.3%). Sealing of the round window membrane was found to be more effective when performed within 8 days after ISSHL. A membrane rupture did not lead to better therapy results. No significant correlation was found between therapy outcome and other clinical symptoms. CONCLUSION: Sealing of the window membrane shows equal results to conservative methods. If patients with hearing loss of more than 60% have more benefit in tympanotomy with sealing of the window membrane than patients with less hearing loss--as shown as in this study--has to be proved in randomized examinations. Intraoperatively found ruptures of the round window membrane had no significant effect on the therapy outcome.

Reineke U; Hühnerschulte M; Ebmeyer J; Sudhoff H

2013-04-01

225

Unilateral hearing loss: benefits and satisfaction from the use of hearing aids.  

UK PubMed Central (United Kingdom)

UNLABELLED: A unilateral hearing loss is characterized by reduced hearing in one ear. The problems caused by sensory deprivation can be minimized with the use of hearing aids (HA). AIM: To analyze the correlation between the prescribed grain and the insertion gain difference and with the results obtained regarding the benefit and satisfaction with the use of hearing aids in unilateral hearing impaired patients. MATERIALS AND METHODS: Prospective study with 15 subjects, mean age of 41.6 years, of both genders, users of hearing aids effectively. We used the International Questionnaire Results for hearing aids (International Outcome Inventory for Hearing Aids - IOI-HA), measured with a probe microphone. RESULTS: The mean values in the analyses of the IOI-HA per item were positive and higher than four points. In relation to the objective measures, the frequencies in which we obtained the gain values which were closer to the target were: 1K Hz, 2K Hz and 500 Hz, respectively. CONCLUSION: The satisfaction of individuals using hearing aid unilaterally is not completely correlated to the prescribed gain, because even if the target is not being reached in some frequencies, the individuals were pleased as to the use of their hearing aids.

José MR; Campos PD; Mondelli MF

2011-03-01

226

Audiological issues and hearing loss among Veterans with mild traumatic brain injury  

Directory of Open Access Journals (Sweden)

Full Text Available We examined the prevalence, severity, etiology, and treatment of audiology problems among Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Veterans with mild traumatic brain injury (TBI). A retrospective chart review was performed of 250 Veterans with mild TBI. Results of a comprehensive second-level mild TBI evaluation and subsequent visits to audiology were evaluated. We found the vast majority (87%) of Veterans reported some level of hearing disturbance and those involved in blast injuries reported a higher incidence of hearing disturbance than those with other injury etiologies. Audiology referrals were given to 75 Veterans and 37 attended. At this visit, Veterans reported tinnitus (75.7%) and hearing loss (59.8%). Nearly half (48.6%) of Veterans were diagnosed with conductive hearing loss, sensorineural hearing loss, or central auditory dysfunction. An additional 24.3% of Veterans had subclinical levels of auditory dysfunction. Our study has highlighted the increased prevalence of hearing loss among OIF/OEF Veterans and, thus, the need for appropriate referrals and treatment. Strategies to address perceived stigma associated with hearing loss may increase attendance at follow-up visits. Additionally, while only a third of audiograms were found to be abnormal, advanced testing resulted in a significant percentage of our population being diagnosed with auditory dysfunction.

Michael Oleksiak; Bridget M. Smith, PhD; Justin R. St. Andre, MA; Carly M. Caughlan, AuD; Monica Steiner, MD

2012-01-01

227

Perception of dissonance by people with normal hearing and sensorineural hearing loss  

Science.gov (United States)

The purpose of this study was to determine whether the perceived sensory dissonance of pairs of pure tones (PT dyads) or pairs of harmonic complex tones (HC dyads) is altered due to sensorineural hearing loss. Four normal-hearing (NH) and four hearing-impaired (HI) listeners judged the sensory dissonance of PT dyads geometrically centered at 500 and 2000 Hz, and of HC dyads with fundamental frequencies geometrically centered at 500 Hz. The frequency separation of the members of the dyads varied from 0 Hz to just over an octave. In addition, frequency selectivity was assessed at 500 and 2000 Hz for each listener. Maximum dissonance was perceived at frequency separations smaller than the auditory filter bandwidth for both groups of listners, but maximum dissonance for HI listeners occurred at a greater proportion of their bandwidths at 500 Hz than at 2000 Hz. Further, their auditory filter bandwidths at 500 Hz were significantly wider than those of the NH listeners. For both the PT and HC dyads, curves displaying dissonance as a function of frequency separation were more compressed for the HI listeners, possibly reflecting less contrast between their perceptions of consonance and dissonance compared with the NH listeners.

Tufts, Jennifer B.; Molis, Michelle R.; Leek, Marjorie R.

2005-08-01

228

Challenges and successes in recruiting firefighters for hearing loss prevention research.  

UK PubMed Central (United Kingdom)

Noise-induced hearing loss (NIHL) is a significant occupational health problem in the United States, affecting more than 1 million firefighters. Noise hazards include vehicles, sirens, and power tools. Additionally, firefighters are commonly exposed to ototoxic chemicals. Because the use of hearing protection is not universally required for firefighters, firefighters must be educated about NIHL to ensure they take personal responsibility for hearing loss prevention. This study discusses challenges associated with recruiting firefighters to participate in a randomized, controlled trial testing a web-based hearing protection training program. Successful recruitment strategies included collaboration with key stakeholders, a flexible and convenient computer-based intervention, expansion to multiple recruitment sites, and interactive outreach to potential participants. Future research should use quantitative methods to evaluate and compare the effectiveness of specific recruitment strategies to facilitate firefighter enrollment in research studies. Developing and testing effective hearing protection interventions for firefighters is a crucial first step toward preventing NIHL in this population.

Hong O; Fiola LA; Feld J

2013-06-01

229

[To analyse the impact of tinnitus loudness and hearing loss on the life of tinnitus patient].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To analyse the impact of tinnitus loudness, tinnitus frequency, hearing loss, tinnitus subjective loudness on the life of tinnitus patient. METHOD: To inspect the 154 tinnitus patients with pure tone audiometry, tinnitus maching, tinnitus classification questionnaire and THI scale. This study applies THI scale to evaluate the impact of tinnitus on the life of tinnitus patient. Using statistical methods to analyse the relationship between tinnitus loudness, tinnitus frequency, hearing loss, tinnitus subjective loudness and the impact of tinnitus on the life of tinnitus patient. RESULT: (1) Tinnitus frequency is closed with the frequency of hearing loss. (2) There is no significant correlation between tinnitue loudness and the impact of tinnitus on the life of tinnitus patient. (3) There is no distinction between hearing loss and the THI scores. (4) The patient gets more scores in subgroup of THI with the increase of tinnitus subjective loudness classification. CONLUSION: The impact of tinnitus loudness, hearing loss on the life of tinnitus patient is not very clearly, while the impact of tinnitus subjective loudness classification on the life of tinnitus patient is significant. In clinical, we can not evaluate the effect of the tinnitus treatment relying on tinnitus loudness and hearing loss simply.The finding provides us individual treatment to tinnitus patients.

Yang J; Zhou H; Yang D

2013-05-01

230

Effects of simvastatin on plasma lipoproteins and hearing loss in apolipoprotein E gene-deficient mice.  

UK PubMed Central (United Kingdom)

Apolipoprotein E (ApoE) gene knockout (KO) mice develop hearing loss, as well as hair cell damage in the inner ear. Furthermore, the hearing loss and hair cell damage may be caused and exacerbated by hyperlipidemia and atherosclerosis. We are therefore seeking an effective treatment to protect the inner ear in ApoE-KO mice. ApoE-KO mice fed with an atherosclerotic diet were treated with simvastatin or with Strauss Heartdrops. The auditory brainstem responses were recorded, and plasma lipid levels and inner ear histology were examined. ApoE-KO and wild-type C57BL/6J mice fed with a normal chow diet served as controls. Compared to ApoE-KO mice fed only the atherosclerotic diet, ApoE-KO mice treated with simvastatin had no significant hearing loss and less severe atherosclerosis and hair cell damage in the inner ear. However, ApoE-KO mice treated with Strauss Heartdrops developed significant hearing loss and severe atherosclerosis and hair cell damage in the inner ear. These results demonstrate that statins may prevent hearing loss and inner ear damage in ApoE-KO mice by reducing the atherosclerotic lesions and levels of glucose, cholesterol, low-density lipoprotein, and triglyceride. Statins could be used to treat hearing loss associated with hyperlipidemia.

Cai Q; Du X; Zhou B; Cai C; Kermany MH; Zhang C; Yoo T

2009-01-01

231

Effects of simvastatin on plasma lipoproteins and hearing loss in apolipoprotein E gene-deficient mice.  

Science.gov (United States)

Apolipoprotein E (ApoE) gene knockout (KO) mice develop hearing loss, as well as hair cell damage in the inner ear. Furthermore, the hearing loss and hair cell damage may be caused and exacerbated by hyperlipidemia and atherosclerosis. We are therefore seeking an effective treatment to protect the inner ear in ApoE-KO mice. ApoE-KO mice fed with an atherosclerotic diet were treated with simvastatin or with Strauss Heartdrops. The auditory brainstem responses were recorded, and plasma lipid levels and inner ear histology were examined. ApoE-KO and wild-type C57BL/6J mice fed with a normal chow diet served as controls. Compared to ApoE-KO mice fed only the atherosclerotic diet, ApoE-KO mice treated with simvastatin had no significant hearing loss and less severe atherosclerosis and hair cell damage in the inner ear. However, ApoE-KO mice treated with Strauss Heartdrops developed significant hearing loss and severe atherosclerosis and hair cell damage in the inner ear. These results demonstrate that statins may prevent hearing loss and inner ear damage in ApoE-KO mice by reducing the atherosclerotic lesions and levels of glucose, cholesterol, low-density lipoprotein, and triglyceride. Statins could be used to treat hearing loss associated with hyperlipidemia. PMID:19738398

Cai, Qing; Du, Xiaoping; Zhou, Bin; Cai, Chun; Kermany, Mohammand Habiby; Zhang, Chunxiang; Yoo, Taijune

2009-09-09

232

Occupational noise exposure and hearing loss characteristics of a blue-collar population  

Energy Technology Data Exchange (ETDEWEB)

Recent studies of health effects from chronic exposure to noise in the workplace have not consistently addressed nonoccupational variables. A cross-sectional study was conducted with 197 randomly selected male hourly workers from a noisy plant ( greater than or equal to 89 dBA) in Pittsburgh to fully assess noise exposure and hearing loss, incorporating information on duration of exposure, noise level, occupational and medical histories, audiometric evaluation, and external noise sources. Population audiometric profiles are characteristic of noise-induced hearing loss; mean hearing thresholds for press room men were significantly higher at 2, 3, and 6 kHz (p less than or equal to .05). Only 40% of the men consistently wore hearing protection. Recent use of ototoxic drugs, noisy hobbies/second jobs, military service, family history of hearing loss, and ear-related problems were not found to have a significant effect on hearing levels at high frequencies, suggesting that observed hearing losses were of an occupational origin. 31 references, 3 figures, 3 tables.

Helmkamp, J.C.; Talbott, E.O.; Margolis, H.

1984-12-01

233

Word Recognition for Temporally and Spectrally Distorted Materials : The Effects of Age and Hearing Loss  

DEFF Research Database (Denmark)

Objectives: The purpose of Experiment 1 was to measure word recognition in younger adults with normal hearing when speech or babble was temporally or spectrally distorted. In Experiment 2, older listeners with near-normal hearing and with hearing loss (for pure tones) were tested to evaluate their susceptibility to changes in speech level and distortion types. The results across groups and listening conditions were compared to assess the extent to which the effects of the distortions on word recognition resembled the effects of age-related differences in auditory processing or pure-tone hearing loss. Design: In Experiment 1, word recognition was measured in 16 younger adults with normal hearing using Northwestern University Auditory Test No. 6 words in quiet and the Words-in-Noise test distorted by temporal jittering, spectral smearing, or combined jittering and smearing. Another 16 younger adults were evaluated in four conditions using the Words-in-Noise test in combinations of unaltered or jittered speech and unaltered or jittered babble. In Experiment 2, word recognition in quiet and in babble was measured in 72 older adults with near-normal hearing and 72 older adults with hearing loss in four conditions: unaltered, jittered, smeared, and combined jittering and smearing. Results: For the listeners in Experiment 1, word recognition was poorer in the distorted conditions compared with the unaltered condition. The signal to noise ratio at 50% correct word recognition was 4.6 dB for the unaltered condition, 6.3 dB for the jittered, 6.8 dB for the smeared, 6.9 dB for the double-jitter, and 8.2 dB for the combined jitter-smear conditions. Jittering both the babble and speech signals did not significantly reduce performance compared with jittering only the speech. In Experiment 2, the older listeners with near-normal hearing and hearing loss performed best in the unaltered condition, followed by the jitter and smear conditions, with the poorest performance in the combined jitter-smear condition in both quiet and noise. Overall, listeners with near-normal hearing performed better than listeners with hearing loss by similar to 30% in quiet and similar to 6 dB in noise. In the quiet distorted conditions, when the level of the speech was increased, performance improved for the hearing loss group, but decreased for the older group with near-normal hearing. Recognition performance of younger listeners in the jitter-smear condition and the performance of older listeners with near-normal hearing in the unaltered conditions were similar. Likewise, the performance of older listeners with near-normal hearing in the jitter-smear condition and the performance of older listeners with hearing loss in the unaltered conditions were similar. Conclusions: The present experiments advance our understanding regarding how spectral or temporal distortions of the fine structure of speech affect word recognition in older listeners with and without clinically significant hearing loss. The Speech Intelligibility Index was able to predict group differences, but not the effects of distortion. Individual differences in performance were similar across all distortion conditions with both age and hearing loss being implicated. The speech materials needed to be both spectrally and temporally distorted to mimic the effects of age-related differences in auditory processing and hearing loss.

Smith, Sherri L.; Pichora-Fuller, Margaret Kathleen

2012-01-01

234

Dermatoglyphics in congenital profound sensorineural hearing loss: a disease marker?  

UK PubMed Central (United Kingdom)

A dermatoglyphic profile was carried out in 108 cases of congenital profound sensorineural hearing loss (SNHL) with delayed development of speech and language (DDSL). Rolled finger prints and palmar patterns were obtained by the ink method and analysed by the Galton system. In the genetic group (Group A) triradii 6 was present whereas it was absent in the nongenetic (Group B) group and their controls (p < 0.001). Loop pattern in interdigital areas did not vary significantly from controls. The average 'atd' angle in Group A was 41 degrees and that in the Group B was 46 degrees (p > 0.5). Ulnar loops predominated over the radial loops. Absence of CPW on thumbs of Group A was noted. Total ridge count in the Group A was 98.84 and 109 in the Group B (p < 0.05). It was observed that no definite pattern existed in a constant fashion and it also exhibited a great degree of variation, hence their role in detection of hearing loss is questionable.

Chaturvedi VN; Kumar S

1993-06-01

235

Sensory-neural hearing loss in pseudoexfoliation syndrome.  

UK PubMed Central (United Kingdom)

AIM: To evaluate relationship between ocular pseudoexfoliation syndrome(PXF) and sensory-neural hearing loss (SNHL). METHODS: This prospective case-control study was designed on patients who referred to a general ophthalmic clinic at Imam Khomeini Medical Center, Urmia, Iran (March 2010 through November 2010). On routine ophthalmic examination, patients diagnosed with ocular PXF were referred to the ENT department and, selected cases (after evaluating inclusion and exclusion criteria) were referred to Audiometric Department. Pure tone hearing threshold level(HTL) was measured at 1, 2, 3 kHz for each ear and was compared with International Standard (ISO 7029) median age associated hearing loss at 1, 2, 3 kHz (AAHL). RESULTS: Overall 21 of 50 patients (42.0%) had a higher HTL than the ISO 7029 median AAHL at 1, 2 and 3kHz, which included 14 ears of 23 patients in the male group (30.4%) and 21 ears of 27 patients in the female group (38.8%). Approximately 12.0% of patients had glaucoma at the same time, however; no significant correlation was found in SNHL prevalence and severity between PXF patient and patients with simultaneous glaucoma. SNHL was more common in patients with ocular PXF compared to their age- sex matched controls (P <0.05). CONCLUSION: Most of patients with ocular PXF had SNHL compared to their age-sex matched controls, which could be due to PXF fibrils in the inner ear. These findings suggest PXF could be a systemic disease.

Samarai V; Samarei R; Haghighi N; Jalili E

2012-01-01

236

Using the extended parallel process model to prevent noise-induced hearing loss among coal miners in Appalachia  

Energy Technology Data Exchange (ETDEWEB)

Occupational noise-induced hearing loss is the second most self-reported occupational illness or injury in the United States. Among coal miners, more than 90% of the population reports a hearing deficit by age 55. In this formative evaluation, focus groups were conducted with coal miners in Appalachia to ascertain whether miners perceive hearing loss as a major health risk and if so, what would motivate the consistent wearing of hearing protection devices (HPDs). The theoretical framework of the Extended Parallel Process Model was used to identify the miners' knowledge, attitudes, beliefs, and current behaviors regarding hearing protection. Focus group participants had strong perceived severity and varying levels of perceived susceptibility to hearing loss. Various barriers significantly reduced the self-efficacy and the response efficacy of using hearing protection.

Murray-Johnson, L.; Witte, K.; Patel, D.; Orrego, V.; Zuckerman, C.; Maxfield, A.M.; Thimons, E.D. [Ohio State University, Columbus, OH (US)

2004-12-15

237

Progression of noise-induced hearing loss. A survey of workers in selected industries in Canada  

Energy Technology Data Exchange (ETDEWEB)

An in-depth investigation of the progression of noise induced hearing loss is reported for individuals working in three major Canadian industries. The particular approach taken was to select occupational groups within each industry, who had the same noise exposure for a continuous period, and on whom standard hearing tests were undertaken at regular intervals. Two methods of evaluating the audiometric data were used. The first was a cross-sectional design, in which one audiogram was analyzed for each employee. The second focused on the rate of hearing loss over time within individuals. The results confirmed previous reports that the effect of continuous noise exposure was maximal in the region of 2-6 kHz. Significant differences in hearing loss were noted across job types. Over a 10 year period the rate of loss within exposed individuals was on the average 1.5 dB per year for 4 kHz, as compared with 0.5 dB for control subjects who held office jobs. The absolute difference between hearing thresholds measured at the beginning and end of this period ranged widely from a slight improvement in hearing to losses often as great as 55 dB. In general the greatest loss occurred at 4 kHz. The number of frequencies at which there was a risk of exceeding a 25 dB fence increased with the number of years of exposure.

Abel, S.M.; Haythornthwaite, C.A.

1984-04-01

238

Severe hearing loss in Pallister-Killian syndrome.  

Science.gov (United States)

Pallister-Killian syndrome is a rare disorder characterised by a specific combination of anatomic anomalies, mental retardation and lack of speech acquisition due to tetrasomy 12p. Hearing loss does not seem to be characteristic for this syndrome, although it was reported in several cases. We present the case of a girl first seen in our department at the age of 6 months. A severe sensory hearing loss was confirmed by subjective and objective audiometry. The child was successfully equipped with hearing aids. In the literature almost all children with Pallister-Killian syndrome are described as not developing verbal speech. Surprisingly their hearing abilities were not examined systematically. We advise audiological testing of children with Pallister-Killian syndrome. PMID:12417777

Schuster, Maria; Hoppe, U; Eysholdt, U; Rosanowski, F

239

Severe hearing loss in Pallister-Killian syndrome.  

UK PubMed Central (United Kingdom)

Pallister-Killian syndrome is a rare disorder characterised by a specific combination of anatomic anomalies, mental retardation and lack of speech acquisition due to tetrasomy 12p. Hearing loss does not seem to be characteristic for this syndrome, although it was reported in several cases. We present the case of a girl first seen in our department at the age of 6 months. A severe sensory hearing loss was confirmed by subjective and objective audiometry. The child was successfully equipped with hearing aids. In the literature almost all children with Pallister-Killian syndrome are described as not developing verbal speech. Surprisingly their hearing abilities were not examined systematically. We advise audiological testing of children with Pallister-Killian syndrome.

Schuster M; Hoppe U; Eysholdt U; Rosanowski F

2002-09-01

240

Determination of Hearing Loss Prevalence in Preschool Children of Ahwaz  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Children learn to communicate by hearing sounds. If there is hearing loss, the cognitive and speaking abilities and language learning will deteriorate. Early detection and intervention are important factors in the successful treatment of hearing loss in children. Hearing loss (HL) is divided into two main groups: conductive hearing loss (CHL) and sensorineural hearing loss (SNHL), the prevalence of the former being higher in children, many whose causes are easy to detect and treat. Material and Methods: In this descriptive, cross-sectional study, 785 children, aged 6-7 years, entering elementary school Grade 1 in the school year 2010/2011, were randomly selected from 10% of Ahwaz Hearing Loss Screening Centers, and their audiograms were studied. The collected data were analyzed using SPSS and descriptive statistics. Results: Out of the 785 preschool children examined in this study, 77 children (9.8%) suffered from HL (42.9% female and 57.1% male), 59.7% from CHL, and 40.3% from SNHL. Twenty-six percent suffered from bilateral HL and 74% from unilateral HL. Thirty-eight point ninety-six percent had abnormal tympanometry, 61% of whom were Type B. Most of the children (53%) had mild HL. Thirty-one point two percent of parents were aware of their children's HL. Conclusion: Considering the high prevalence of HL, especially SNHL, in this study, which is usually permanent but detectable at the neonatal ages, raising public awareness and early screening of ear diseases, which can lead to the detection and treatment in most cases, seem to be vital.

Mozafar Sarafraz; Mahmood Hekmat-Shoar; Sara Zaheri

2011-01-01

 
 
 
 
241

Role of cochlear efferents in noise induced hearing loss.  

Czech Academy of Sciences Publication Activity Database

loss. Cambridge : NOPHER, 2000, s. 10.[An International Symposium on noise induced hearing loss. Cambridge (GB), 07.07.2000-10.07.2000]Grant CEP: GA ?R GA309/97/0830; GA MZd NK4747Výzkumný zám?r: CEZ:AV0Z5039906Kód oboru RIV: FH - Neurologie, neurochirurgie, neurov?dy

Aran, J. M.; Popelá?, Ji?íG; Smith, D. W.

242

Maternal prenatal smoking and hearing loss among adolescents.  

UK PubMed Central (United Kingdom)

IMPORTANCE: Although smoking and secondhand smoke exposure are associated with sensorineural hearing loss (SNHL) in children and adults, the possible association between prenatal smoke exposure and hearing loss has not been investigated despite the fact that more than 12% of US children experience such prenatal exposure each year. OBJECTIVE: To investigate whether exposure to prenatal tobacco smoke is independently associated with SNHL in adolescents. DESIGN: Cross-sectional data were examined for 964 adolescents aged 12 to 15 years from the National Health and Nutrition Examination Survey 2005-2006. PARTICIPANTS: Participants underwent standardized audiometric testing, and serum cotinine levels and self-reports were used to identify adolescents exposed to secondhand smoke or active smokers. MAIN OUTCOMES AND MEASURES: Prenatal exposure was defined as an affirmative parental response to, "Did [Sample Person's Name] biological mother smoke at any time while she was pregnant with [him/her]?" Sensorineural hearing loss was defined as an average pure-tone hearing level more than 15 dB for 0.5, 1, and 2 kHz (low frequency) and 3, 4, 6, and 8 kHz (high frequency). RESULTS: Parental responses affirmed prenatal smoke exposure in 16.2% of 964 adolescents. Prenatal smoke exposure was associated with elevated pure-tone hearing thresholds at 2 and 6 kHz (P?hearing-related covariates. CONCLUSIONS AND RELEVANCE: Prenatal smoke exposure is independently associated with higher pure-tone hearing thresholds and an almost 3-fold increase in the odds of unilateral low-frequency hearing loss among adolescents. These novel findings suggest that in utero exposure to tobacco smoke may be injurious to the auditory system.

Weitzman M; Govil N; Liu YH; Lalwani AK

2013-07-01

243

[Current aspects of harmonization of classification of occupational hearing loss].  

UK PubMed Central (United Kingdom)

The objective of the present work was to develop unified criteria for the evaluation of the severity of noise-induced hearing loss. Current approaches to taking expert decisions based on the results of medical examination of the patients with impaired hearing are substantially different due to the considerable difference between the criteria for the estimation of hearing envisaged by the international classification, occupational pathology classification, and the national system of medico-social expertise. We undertook an attempt to correct and harmonize the existing criteria for the estimation of severity of occupational hearing loss based on the integration of all the three classification in order to "reduce them to a common denominator" and thereby to ensure the basis for the unified diagnostic and expert decisions for the cases of hearing impairment of any etiology. The project proposed in this paper makes it possible to use unified criteria for the assessment of the degree of hearing loss caused by occupational noises for diagnostic purposes and expertise compatible with the internationally accepted approaches.

Pankova VB; Sinëva EL; Tavartkiladze GA; Fedina IN; Preobrazhenskaia EA; Mukhamedova GR

2013-01-01

244

Hair Color and Hearing Loss: A Survey in a Group of Military Men  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: It has been shown that low levels of pigmentation increase susceptibility to noise-induced hearing loss in humans. For this reason, white populations develop more pronounced noise- induced hearing loss in comparison to black populations. Similarly, blue-eyed individuals exhibit greater temporary threshold shift than brown-eyed subjects; still, no strong correlation has been verified between the lightness of hair color and susceptibility to noise-induced hearing loss. This study was performed with the purpose of investigating a possible association between hair color and the degree of hearing loss due to firing noise. Study Design: Prospective observational study. Setting: A tertiary referral center with an accredited otorhinolaryngology-head & neck surgery department.   Materials and Methods: A total of 57 military recruits were divided into two groups; light-colored (blond and light brown) and dark-colored hair (dark brown and black). The two groups were matched based on history of firing noise exposure (number of rounds; type of weapon) and the level of hearing loss at 2, 3, 4, 6 and 8 kHz sound frequencies was compared between them.   Results: The results showed that the mean level of hearing loss of light-colored hair individuals (20.5±17dB) was significantly greater than that of dark-haired subjects (13.5±11dB), (P=0.023).   Conclusion: The results indicate that hair color (blond versus black) can be used as an index for predicting susceptibility to noise-induced hearing loss in military environments. Therefore, based on the individual's hair color, upgraded hearing conservation programs are highly recommended.

Amir Hossain Ghazizadeh; Mehdi Bakhshaee; Ebrahim Mahdavi; Rahman Movahhed

2011-01-01

245

Perda auditiva induzida pelo ruído em trabalhadores de metalúrgica/ Noise induced hearing loss in metallurgical workers  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Introdução: A perda auditiva induzida pelo ruído é uma patologia insidiosa cumulativa, que cresce ao longo dos anos de exposição ao ruído associado ao ambiente de trabalho. Objetivos: Identificar e quantificar a ocorrência de alterações auditivas sugestivas de Perda Auditiva Induzida pelo Ruído e os principais sintomas otorrinolaringológicos referidos pelos trabalhadores. Forma de estudo: prospectivo clínico randomizado. Casuística e métodos: Pesquisa reali (more) zada no período de janeiro a março de 2000 com 187 trabalhadores de indústria metalúrgica no município de Goiânia, avaliados por médicos otorrinolaringologistas através de roteiro de entrevista e audiometria ocupacional. Resultados: Foram obtidas audiometrias ocupacionais sendo: 21% sugestivas de PAIR, 72%, normais e 7%, sugestivas de outras doenças auditivas. Os sintomas auditivos mais freqüentes foram: dificuldade de compreensão da fala, 12%; hipoacusia, 7%; tinitus, 13%; sensação de plenitude auricular, 4%; otorreia, 6%; tonturas, 12%. Conclusão: Concluímos que em metalúrgica há ocorrência de alterações auditivas sugestivas de Perda Auditiva Induzida pelo Ruído e queixa de sintomas otorrinolaringológicos significativos. Abstract in english Introduction: Noise induced hearing loss is a cumulative pathological disease that increases over the years with exposure to noise associated with the work atmosphere. Objectives: To identify and quantify the occurrence of hearing loss suggestive of Noise Induced Hearing Loss (NIHL) and the principle otolaryngological symptoms referred to by workers. Study design: prospective clinical randomized. Material and method: Research was carried out from January to March of 2000 (more) with 187 metallurgical workers in the city of Goiânia, who were evaluated by otolaryngologists by means of a combination of interviews and occupational hearing exams. Results: Occupational hearing tests results were: 21% suggestive of NIHL, 72% normal, and 7% suggestive of other hearing impairments. The most frequent hearing symptoms were: difficulty of comprehension in speaking 12%, Hearing loss 7%, Tinnitus 13%, Auricular fullness feeling 4%, Effusion 6%, and Dizziness 12%. Conclusion: We concluded that in metallurgist exists an occurrence of hearing loss suggestive of NIHL and complaints of significant otolaryngological symptoms.

Araújo, Simone Adad

2002-05-01

246

Perda auditiva induzida pelo ruído em trabalhadores de metalúrgica Noise induced hearing loss in metallurgical workers  

Directory of Open Access Journals (Sweden)

Full Text Available Introdução: A perda auditiva induzida pelo ruído é uma patologia insidiosa cumulativa, que cresce ao longo dos anos de exposição ao ruído associado ao ambiente de trabalho. Objetivos: Identificar e quantificar a ocorrência de alterações auditivas sugestivas de Perda Auditiva Induzida pelo Ruído e os principais sintomas otorrinolaringológicos referidos pelos trabalhadores. Forma de estudo: prospectivo clínico randomizado. Casuística e métodos: Pesquisa realizada no período de janeiro a março de 2000 com 187 trabalhadores de indústria metalúrgica no município de Goiânia, avaliados por médicos otorrinolaringologistas através de roteiro de entrevista e audiometria ocupacional. Resultados: Foram obtidas audiometrias ocupacionais sendo: 21% sugestivas de PAIR, 72%, normais e 7%, sugestivas de outras doenças auditivas. Os sintomas auditivos mais freqüentes foram: dificuldade de compreensão da fala, 12%; hipoacusia, 7%; tinitus, 13%; sensação de plenitude auricular, 4%; otorreia, 6%; tonturas, 12%. Conclusão: Concluímos que em metalúrgica há ocorrência de alterações auditivas sugestivas de Perda Auditiva Induzida pelo Ruído e queixa de sintomas otorrinolaringológicos significativos.Introduction: Noise induced hearing loss is a cumulative pathological disease that increases over the years with exposure to noise associated with the work atmosphere. Objectives: To identify and quantify the occurrence of hearing loss suggestive of Noise Induced Hearing Loss (NIHL) and the principle otolaryngological symptoms referred to by workers. Study design: prospective clinical randomized. Material and method: Research was carried out from January to March of 2000 with 187 metallurgical workers in the city of Goiânia, who were evaluated by otolaryngologists by means of a combination of interviews and occupational hearing exams. Results: Occupational hearing tests results were: 21% suggestive of NIHL, 72% normal, and 7% suggestive of other hearing impairments. The most frequent hearing symptoms were: difficulty of comprehension in speaking 12%, Hearing loss 7%, Tinnitus 13%, Auricular fullness feeling 4%, Effusion 6%, and Dizziness 12%. Conclusion: We concluded that in metallurgist exists an occurrence of hearing loss suggestive of NIHL and complaints of significant otolaryngological symptoms.

Simone Adad Araújo

2002-01-01

247

Hearing loss after spinal anesthesia: the effect of different infusion solutions.  

UK PubMed Central (United Kingdom)

OBJECTIVE: We speculate that the preoperative volume replacement with a convenient solution may protect the inner ear function after spinal anesthesia. METHODS: The patients were randomized in a single-blind fashion into two groups: group LR (n = 40) received lactated Ringer's and group GF (n = 40) received gelatin polysuccinate 4% (Gelofusine). Spinal anesthesia was performed with a 25 G Quincke needle and was given bupivacaine 0.5% 10 mg and fentanyl 25 microg. Audiograms were performed preoperatively and 2 days postoperatively. RESULTS: The overall incidence of hearing loss was 7.5%. The hearing loss was unilateral in two and bilateral in four patients. Hearing loss occurred within the low-frequency range and the hearing thresholds returned to normal by the fifth postoperative day. CONCLUSIONS: Although the incidence of hearing loss for the lactated Ringer's group was higher than the Gelofusine group, there was no statistically significant difference between the groups. For medicolegal and ethical reasons, patients should be informed about the possibility of hearing loss after spinal anesthesia.

Yildiz TS; Solak M; Iseri M; Karaca B; Toker K

2007-07-01

248

Traumatic labyrinthine concussion in a patient with sensorineural hearing loss.  

UK PubMed Central (United Kingdom)

Blunt head trauma without any temporal bone fracture or longitudinal temporal bone fracture, with an associated fracture of the labyrinth may cause labyrinthine injury with sensor neural hearing loss and vertigo because of a concussive injury to the membranous labyrinth. Sudden sensory neural hearing loss is relatively frequent. In most cases, the etiology is not discovered. One of the possible causes for sudden deafness is inner labyrinth bleeding or concussion, which were difficult to diagnose before the advent of magnetic resonance imaging. Vertigo without a demonstrable fracture may also be the result of labyrinthine concussion, cupololithiasis and perilymphatic fistula. We describe the clinical case of a patient with acute traumatic hearing loss and vertigo, without skull base fracture detected on computed tomography. Magnetic resonance study was also performed. We have integrated the discussion with features that allow the differential diagnosis from other similar conditions.

Chiaramonte R; Bonfiglio M; D'Amore A; Viglianesi A; Cavallaro T; Chiaramonte I

2013-02-01

249

Acute unilateral hearing loss as an unusual presentation of cholesteatoma  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Cholesteatomas are epithelial cysts that contain desquamated keratin. Patients commonly present with progressive hearing loss and a chronically discharging ear. We report an unusual presentation of the disease with an acute hearing loss suffered immediately after prolonged use of a pneumatic drill. Case presentation A 41 year old man with no previous history of ear problems presented with a sudden loss of hearing in his right ear immediately following the prolonged use of a pneumatic drill on concrete. The cause was found to be a fractured long process of incus which had been eroded by the presence of an attic cholesteatoma. A tympanomastoidectomy and ossiculoplasty was performed with good result. Conclusion Cholesteatomas may be asymptomatic and insidious in their onset. This case illustrates the point that an indolent disease such as this may present in unusual ways and the clinician must always have a high index of suspicion combined with thorough assessment and examination of every patient.

Thio Daniel; Ahmed Shahzada K; Bickerton Richard C

2005-01-01

250

The Prevention of Noise Induced Hearing Loss in Children  

Science.gov (United States)

Increasingly, our acoustic environment is filled with amplified sound sources (e.g., MP3 players, video game stations, and sports/entertainment venues). There is serious concern and also some controversy about the risks of acoustic trauma in children. This overview provides some basic information on the physiological mechanisms that lead to noise induced hearing loss, a survey of various studies that, on balance, indicates that there is cause for concern, and finally a discussion on measures that can help to prevent noise induced hearing loss in children. This paper is designed for public health and other healthcare professions (ENT, audiologists, family doctors, and pediatricians) who should understand the risks of noise induced hearing loss and its prevention.

Harrison, Robert V.

2012-01-01

251

The prevention of noise induced hearing loss in children.  

UK PubMed Central (United Kingdom)

Increasingly, our acoustic environment is filled with amplified sound sources (e.g., MP3 players, video game stations, and sports/entertainment venues). There is serious concern and also some controversy about the risks of acoustic trauma in children. This overview provides some basic information on the physiological mechanisms that lead to noise induced hearing loss, a survey of various studies that, on balance, indicates that there is cause for concern, and finally a discussion on measures that can help to prevent noise induced hearing loss in children. This paper is designed for public health and other healthcare professions (ENT, audiologists, family doctors, and pediatricians) who should understand the risks of noise induced hearing loss and its prevention.

Harrison RV

2012-01-01

252

Acute unilateral hearing loss as an unusual presentation of cholesteatoma  

Science.gov (United States)

Background Cholesteatomas are epithelial cysts that contain desquamated keratin. Patients commonly present with progressive hearing loss and a chronically discharging ear. We report an unusual presentation of the disease with an acute hearing loss suffered immediately after prolonged use of a pneumatic drill. Case presentation A 41 year old man with no previous history of ear problems presented with a sudden loss of hearing in his right ear immediately following the prolonged use of a pneumatic drill on concrete. The cause was found to be a fractured long process of incus which had been eroded by the presence of an attic cholesteatoma. A tympanomastoidectomy and ossiculoplasty was performed with good result. Conclusion Cholesteatomas may be asymptomatic and insidious in their onset. This case illustrates the point that an indolent disease such as this may present in unusual ways and the clinician must always have a high index of suspicion combined with thorough assessment and examination of every patient.

Thio, Daniel; Ahmed, Shahzada K; Bickerton, Richard C

2005-01-01

253

Acute unilateral hearing loss as an unusual presentation of cholesteatoma.  

UK PubMed Central (United Kingdom)

BACKGROUND: Cholesteatomas are epithelial cysts that contain desquamated keratin. Patients commonly present with progressive hearing loss and a chronically discharging ear. We report an unusual presentation of the disease with an acute hearing loss suffered immediately after prolonged use of a pneumatic drill. CASE PRESENTATION: A 41 year old man with no previous history of ear problems presented with a sudden loss of hearing in his right ear immediately following the prolonged use of a pneumatic drill on concrete. The cause was found to be a fractured long process of incus which had been eroded by the presence of an attic cholesteatoma. A tympanomastoidectomy and ossiculoplasty was performed with good result. CONCLUSION: Cholesteatomas may be asymptomatic and insidious in their onset. This case illustrates the point that an indolent disease such as this may present in unusual ways and the clinician must always have a high index of suspicion combined with thorough assessment and examination of every patient.

Thio D; Ahmed SK; Bickerton RC

2005-09-01

254

Rescue of inhibitory synapse strength following developmental hearing loss.  

UK PubMed Central (United Kingdom)

Inhibitory synapse dysfunction may contribute to many developmental brain disorders, including the secondary consequences of sensory deprivation. In fact, developmental hearing loss leads to a profound reduction in the strength of inhibitory postsynaptic currents (IPSCs) in the auditory cortex, and this deficit persists into adulthood. This finding is consistent with the general theory that the emergence of mature synaptic properties requires activity during development. Therefore, we tested the prediction that inhibitory strength can be restored following developmental hearing loss by boosting GABAergic transmission in vivo. Conductive or sensorineural hearing loss was induced surgically in gerbils prior to hearing onset and GABA agonists were then administered for one week. IPSCs were subsequently recorded from pyramidal neurons in a thalamocortical brain slice preparation. Administration of either a GABA(A) receptor a1 subunit specific agonist (zolpidem), or a selective GABA reuptake inhibitor (SGRI), rescued IPSC amplitude in hearing loss animals. Furthermore, this restoration persisted in adults, long after drug treatment ended. In contrast, a GABA(B) receptor agonist baclofen did not restore inhibitory strength. IPSCs could also be restored when SGRI administration began 3 weeks after sensory deprivation. Together, these results demonstrate long-lasting restoration of cortical inhibitory strength in the absence of normal experience. This suggests that in vivo GABA(A) receptor activation is sufficient to promote maturation, and this principle may extend to other developmental disorders associated with diminished inhibitory function.

Kotak VC; Takesian AE; MacKenzie PC; Sanes DH

2013-01-01

255

Sensorineural hearing loss in MELAS syndrome--case report.  

Science.gov (United States)

A mitochondrial tRNA mutation at nucleotide 3,243 is known to be found in most patients with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes). We report a 30 year-old female patient of MELAS, diagnosed 5 years ago, who presented herself to our ENT outpatient department because of her bilateral tinnitus and progressive hearing impairment since 4 years ago. Two sequential pure tone audiograms showed bilateral symmetrical progressive sensorineural hearing loss, especially in the high frequency area in 1993 and 1996. The pure tone average was R-45 dB, L-47 dB in 1993 and R-62 dB, L-67 dB in 1996. Hearing loss is an important feature in MELAS syndrome and reported to be seen in about 30% of patients. It is often the first clinical symptom, too. In any case, mitochondrial cytopathies need to be considered by the otologist in forming a diagnosis of sensorineural hearing loss (SNHL), particularly in cases, which present adult-onset progressive hearing loss and neurologic symptoms before 50 years of age. PMID:9780603

Chen, J N; Ho, K Y; Juan, K H

1998-08-01

256

Hearing loss and cognitive decline in older adults.  

Science.gov (United States)

BACKGROUND Whether hearing loss is independently associated with accelerated cognitive decline in older adults is unknown. METHODS We studied 1984 older adults (mean age, 77.4 years) enrolled in the Health ABC Study, a prospective observational study begun in 1997-1998. Our baseline cohort consisted of participants without prevalent cognitive impairment (Modified Mini-Mental State Examination [3MS] score, ?80) who underwent audiometric testing in year 5. Participants were followed up for 6 years. Hearing was defined at baseline using a pure-tone average of thresholds at 0.5 to 4 kHz in the better-hearing ear. Cognitive testing was performed in years 5, 8, 10, and 11 and consisted of the 3MS (measuring global function) and the Digit Symbol Substitution test (measuring executive function). Incident cognitive impairment was defined as a 3MS score of less than 80 or a decline in 3MS score of more than 5 points from baseline. Mixed-effects regression and Cox proportional hazards regression models were adjusted for demographic and cardiovascular risk factors. RESULTS In total, 1162 individuals with baseline hearing loss (pure-tone average >25 dB) had annual rates of decline in 3MS and Digit Symbol Substitution test scores that were 41% and 32% greater, respectively, than those among individuals with normal hearing. On the 3MS, the annual score changes were -0.65 (95% CI, -0.73 to -0.56) vs -0.46 (95% CI, -0.55 to -0.36) points per year (P = .004). On the Digit Symbol Substitution test, the annual score changes were -0.83 (95% CI, -0.94 to -0.73) vs -0.63 (95% CI, -0.75 to -0.51) points per year (P = .02). Compared to those with normal hearing, individuals with hearing loss at baseline had a 24% (hazard ratio, 1.24; 95% CI, 1.05-1.48) increased risk for incident cognitive impairment. Rates of cognitive decline and the risk for incident cognitive impairment were linearly associated with the severity of an individual's baseline hearing loss. CONCLUSIONS Hearing loss is independently associated with accelerated cognitive decline and incident cognitive impairment in community-dwelling older adults. Further studies are needed to investigate what the mechanistic basis of this association is and whether hearing rehabilitative interventions could affect cognitive decline. PMID:23337978

Lin, Frank R; Yaffe, Kristine; Xia, Jin; Xue, Qian-Li; Harris, Tamara B; Purchase-Helzner, Elizabeth; Satterfield, Suzanne; Ayonayon, Hilsa N; Ferrucci, Luigi; Simonsick, Eleanor M

2013-02-25

257

Hearing loss and cognitive decline in older adults.  

UK PubMed Central (United Kingdom)

BACKGROUND Whether hearing loss is independently associated with accelerated cognitive decline in older adults is unknown. METHODS We studied 1984 older adults (mean age, 77.4 years) enrolled in the Health ABC Study, a prospective observational study begun in 1997-1998. Our baseline cohort consisted of participants without prevalent cognitive impairment (Modified Mini-Mental State Examination [3MS] score, ?80) who underwent audiometric testing in year 5. Participants were followed up for 6 years. Hearing was defined at baseline using a pure-tone average of thresholds at 0.5 to 4 kHz in the better-hearing ear. Cognitive testing was performed in years 5, 8, 10, and 11 and consisted of the 3MS (measuring global function) and the Digit Symbol Substitution test (measuring executive function). Incident cognitive impairment was defined as a 3MS score of less than 80 or a decline in 3MS score of more than 5 points from baseline. Mixed-effects regression and Cox proportional hazards regression models were adjusted for demographic and cardiovascular risk factors. RESULTS In total, 1162 individuals with baseline hearing loss (pure-tone average >25 dB) had annual rates of decline in 3MS and Digit Symbol Substitution test scores that were 41% and 32% greater, respectively, than those among individuals with normal hearing. On the 3MS, the annual score changes were -0.65 (95% CI, -0.73 to -0.56) vs -0.46 (95% CI, -0.55 to -0.36) points per year (P = .004). On the Digit Symbol Substitution test, the annual score changes were -0.83 (95% CI, -0.94 to -0.73) vs -0.63 (95% CI, -0.75 to -0.51) points per year (P = .02). Compared to those with normal hearing, individuals with hearing loss at baseline had a 24% (hazard ratio, 1.24; 95% CI, 1.05-1.48) increased risk for incident cognitive impairment. Rates of cognitive decline and the risk for incident cognitive impairment were linearly associated with the severity of an individual's baseline hearing loss. CONCLUSIONS Hearing loss is independently associated with accelerated cognitive decline and incident cognitive impairment in community-dwelling older adults. Further studies are needed to investigate what the mechanistic basis of this association is and whether hearing rehabilitative interventions could affect cognitive decline.

Lin FR; Yaffe K; Xia J; Xue QL; Harris TB; Purchase-Helzner E; Satterfield S; Ayonayon HN; Ferrucci L; Simonsick EM

2013-02-01

258

Is BPPV a Prognostic Factor in Idiopathic Sudden Sensory Hearing Loss?  

Science.gov (United States)

Objectives The prognostic significance of vertigo in patients with idiopathic sudden sensorineural hearing loss (SSNHL) remains a matter of debate because vertigo is associated with many different vestibular disorders. The purpose of this study is to determine the role of benign paroxysmal positional vertigo (BPPV) as a prognostic factor in patients with SSNHL. Methods We conducted a retrospective study of 298 patients with SSNHL. Hearing outcomes were evaluated by assessments of pre-treatment hearing and hearing gain. Comparative multivariate analyses between prognostic factors and hearing outcome were conducted. Results Thirty-eight (12.7%) SSNHL patients were found to also have BPPV. BPPV showed significant negative prognostic factors in hearing outcome on multivariate analysis (odds ratio, 0.15). In comparison to average pure tone audiometry (PTA), patients diagnosed with SSNHL with BPPV exhibited poorer hearing in pre- and post-treatment PTA compared to SSNHL without BPPV. Old age (>60 years), pre-treatment hearing, and canal paresis were significant outcome predictors. Conclusion BPPV in SSNHL patients, representing definitive vestibular damage, was closely related to poor prognosis.

Lee, No Hee

2010-01-01

259

Biochemical and cardiovascular measures in subjects with noise-induced hearing loss  

Energy Technology Data Exchange (ETDEWEB)

Reports on a potential relationship between noise-induced hearing loss (NIHL) and cardiovascular as well as biochemical measures are controversial. This study compares the means of certain cardiovascular and biochemical measures in subjects with NIHL with those in subjects exposed to similar occupational noise, but demonstrating normal hearing. This might indicate certain predisposing factors for NIHL. Eight hundred noise-exposed subjects were divided into two age-matched hearing groups (NIHL and normal hearing). The results showed that the mean values of all the variables examined in both hearing groups were within the normal range. No significant differences were found between the two groups in terms of the distribution of subjects for the indices measured.

Gold, S.; Haran, I.; Attias, J.; Shapira, I.; Shahar, A. (Institute for Noise Hazards Research, Ramat Gan (Israel))

1989-11-01

260

Celiac disease and sensorineural hearing loss in children.  

UK PubMed Central (United Kingdom)

CONCLUSION: Sensorineural hearing loss (SNHL) is a neurological situation and celiac disease (CD) may be seen coincidentally. Children with clinical signs of hearing deficiency of unknown etiology should be assessed for CD. OBJECTIVE: CD is a chronic inflammatory gluten-dependent intestinal disease and has extraintestinal findings. The aim of this study was to determine the incidence of CD and SNHL in our pediatric patients. METHODS: A total of 25 pediatric patients (50 ears) with biopsy-proven CD were diagnosed in the pediatric gastroenterology department; 25 healthy control subjects (50 ears) were also included in the study. All subjects underwent pure tone audiometry at frequencies of 250-8000 Hz and tympanometry. RESULTS: In the patients and controls, normal peak compliance, gradient, peak pressure, ear canal volume, and acoustic reflexes were obtained by tympanometry. There was no air-bone gap in any of the participants. There was a statistically significant difference between the audiometric results in the CD and control groups (right ear and left ear) (p < 0.05).

Solmaz F; Unal F; Apuhan T

2012-02-01

 
 
 
 
261

Wideband aural acoustic absorbance predicts conductive hearing loss in children.  

UK PubMed Central (United Kingdom)

OBJECTIVE: This study tested the hypothesis that wideband aural absorbance predicts conductive hearing loss (CHL) in children medically classified as having otitis media with effusion. DESIGN: Absorbance was measured in the ear canal over frequencies from 0.25 to 8 kHz at ambient pressure or as a swept tympanogram. CHL was defined using criterion air-bone gaps of 20, 25, and 30 dB at octaves from 0.25 to 4 kHz. A likelihood-ratio predictor of CHL was constructed across frequency for ambient absorbance, and across frequency and pressure for absorbance tympanometry. Performance was evaluated at individual frequencies and for any frequency at which a CHL was present. STUDY SAMPLE: Absorbance and conventional 0.226-kHz tympanograms were measured in children of age three to eight years with CHL and with normal hearing. RESULTS: Absorbance was smaller at frequencies above 0.7 kHz in the CHL group than the control group. Based on the area under the receiver operating characteristic curve, wideband absorbance in ambient and tympanometric tests were significantly better predictors of CHL than tympanometric width, the best 0.226-kHz predictor. Accuracies of ambient and tympanometric wideband absorbance did not differ. CONCLUSIONS: Absorbance accurately predicted CHL in children and was more accurate than conventional 0.226-kHz tympanometry.

Keefe DH; Sanford CA; Ellison JC; Fitzpatrick DF; Gorga MP

2012-12-01

262

Cochlear implantation for severe sensorineural hearing loss caused by lightning.  

UK PubMed Central (United Kingdom)

Lightning strike can produce an array of clinical symptoms and injuries. It may damage multiple organs and cause auditory injuries ranging from transient hearing loss and vertigo to complete disruption of the auditory system. Tympanic-membrane rupture is relatively common in patients with lightning injury. The exact pathogenetic mechanisms of auditory lesions in lightning survivors have not been fully elucidated. We report the case of a 45-year-old woman with bilateral profound sensorineural hearing loss caused by a lightning strike, who was successfully rehabilitated after a cochlear implantation.

Myung NS; Lee IW; Goh EK; Kong SK

2012-11-01

263

Hearing loss in the elderly: History of occupational noise exposure  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english INTRODUCTION: Noise exposure is one of the most common health risk factors, and workers are exposed to sound pressure levels capable of producing hearing loss. AIM: To assess the prevalence of hearing loss in the elderly and its possible association with a history of occupational noise exposure and with sex. METHODS: A prospective study in subjects aged over 60 years. The subjects underwent anamnesis and audiological assessment. The Mann-Whitney test and multiple logistic (more) regression, with 95% confidence interval and p

Meneses-Barriviera, Caroline Luiz; Melo, Juliana Jandre; Marchiori, Luciana Lozza de Moraes

2013-06-01

264

Intratympanic injection of dexamethasone for treatment of tinnitus in patients with sudden sensorineural hearing loss  

Directory of Open Access Journals (Sweden)

Full Text Available The purpose of this study is to test the effectiveness of intratympanic dexamethasone injections as a treatment for severe tinnitus in idiopathic sudden sensorineural hearing loss (SNHL). We studied 37 patients who received intratympanic dexamethasone injections and 14 control patients who did not receive it, with severe tinnitus after onset of unilateral sudden SNHL. Hearing level did not change during this study in any patient. The relationship between the duration of tinnitus and effectiveness of treatment was investigated in sudden SNHL. We used a visual analogue scale to evaluate 51 patients with severe tinnitus at the stage of stable hearing level after idiopathic sudden sensorineural hearing loss. Forty-one per cent of patients showed significant improvement after treatment. The average period between onset of sudden sensorineural hearing loss and initiation of intratympanic dexamethasone injection was significantly shorter (207 days) in the improved group than in the unchanged group (482 days) (P<0.001). In control group, one of 14 patients presented significant improvement spontaneously. Intratympanic dexamethasone treatment may be effective in treatment of severe tinnitus after sudden SNHL at the stage of stable hearing level, and the shorter the period from onset of sudden deafness to the start of intratympanic dexamethasone treatment, the greater the improvement in tinnitus that can be expected.

Tadao Yoshida; Masaaki Teranishi; Tomoyuki Iwata; Hironao Otake; Tsutomu Nakashima

2012-01-01

265

Correlation between hearing loss and the results of the following questionnaires: Hearing Handicap Inventory for the Adults - Screening Version HHIA-S and Hearing Handicap Inventory for the Elderly - Screening Version - HHIE-S  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: The self-assessment questionnaires are useful to measure the emotional and social/transient consequences resulting from hearing loss, and they can be used in a wide range of situations in the clinical routine, such as auditory screening. Objective: Check the sensitivity and specificities of HHIA-S and HHIE-S questionnaires to identify a hearing loss and their usages in auditory screenings, as well as analyze the ability of these questionnaires to detect different degrees of hearing impairments in the studied people. Method: Retrospective study with 51 individuals aged between 18 and 88, who filled out the Hearing Handicap Inventory for Adults Screening Version - HHIA-S and Hearing Handicap Inventory for the Elderly Screening Version - HHIE-S questionnaires at the waiting room of the Brazilian Unified Health System (SUS)'s otorhinolaryngology infirmary. Results: The instruments showed a low sensitivity (47%), not identifying individuals with a hearing loss; however, they showed a high specificity (75%), accurately identifying individuals with no hearing disorder. Moreover, no significant association between the degree of hearing loss and the constraint degree for participation was found. Conclusion: the aforementioned questionnaires revealed a low sensitivity and a high specificity, proving to be ineffective for auditory screenings in a group with previous hearing complaints in addition to being unable to detect different types and degrees of hearing impairment.

Menegotto, Isabela Hoffmeister; Soldera, Cristina Loureiro Chaves; Anderle, Paula; Anhaia, Tanise Cristaldo

2011-01-01

266

Sensorineural hearing loss following irradiation to the malignant tumor of the head and neck  

Energy Technology Data Exchange (ETDEWEB)

We observed sensorineural hearing loss following X-ray irradiation to the malignant tumor of head and neck. There were 24 patients whose auditory organs lied within the irradiation field. Ten of these patients were affected by sensorineural hearing loss. Hearing loss occurred at a high frequency in elderly patients, epipharynx tumor and high dose of irradiation. Many cases revealed high tone hearing loss. Most cases showed about a 20/similar to/30 dB hearing loss, so their impediment seemed not severe in daily life. In some of these cases, we could have temporal bone findings, but there were no particular findings relevant to sensorineural hearing loss. (author).

Murakami, Masafumi; Kobari, Hitomi; Kanno, Hidetaka; Aikawa, Tohru; Anzai, Tomohiro; Okamura, Hiro-oki; Ohtani, Iwao; Hoshino, Toshiaki

1989-03-01

267

Sensorineural hearing loss following irradiation to the malignant tumor of the head and neck  

International Nuclear Information System (INIS)

We observed sensorineural hearing loss following X-ray irradiation to the malignant tumor of head and neck. There were 24 patients whose auditory organs lied within the irradiation field. Ten of these patients were affected by sensorineural hearing loss. Hearing loss occurred at a high frequency in elderly patients, epipharynx tumor and high dose of irradiation. Many cases revealed high tone hearing loss. Most cases showed about a 20?30 dB hearing loss, so their impediment seemed not severe in daily life. In some of these cases, we could have temporal bone findings, but there were no particular findings relevant to sensorineural hearing loss. (author).

1989-01-01

268

Occupational noise-induced hearing loss in India  

Directory of Open Access Journals (Sweden)

Full Text Available Noise is the insidious of all industrial pollutants, involving every industry and causing severe hearing loss in every country in the world. Exposure to excessive noise is the major avoidable cause of permanent hearing impairment. Worldwide, 16% of the disabling hearing loss in adults is attributed to occupational noise, ranging from 7 to 21% in the various subregions. The estimated cost of noise to developed countries ranges from 0.2 to 2% of the gross domestic product (GDP). Noise-induced hearing loss (NIHL) is bilateral and symmetrical, usually affecting the higher frequencies (3k, 4k or 6k Hz) and then spreading to the lower frequencies (0.5k, 1k or 2k Hz). Other major health effects are lack of concentration, irritation, fatigue, headache, sleep disturbances, etc. The major industries responsible for excessive noise and exposing workers to hazardous levels of noise are textile, printing, saw mills, mining, etc. Hearing protectors should be used when engineering controls and work practices are not feasible for reducing noise exposure to safe levels. Earmuffs, ear plugs and ear canal caps are the main types of hearing protectors. In India, NIHL has been a compensable disease since 1948. It is only in 1996 that the first case got compensation. Awareness should be created among workers about the harmful effects of noise on hearing and other body systems by implementing compulsory education and training programs. There are very few published studies of NIHL in India. More extensive studies are needed to know the exact prevalence of NIHL among the various industries in India.

Nandi Subroto; Dhatrak Sarang

2008-01-01

269

Mechanism study of laser cochleostomy-induced early hearing loss in a rat model.  

UK PubMed Central (United Kingdom)

Hearing loss following laser-assisted ear surgery has been reported. However, the mechanism responsible for the hearing loss remains largely speculative. The aim of this study was to investigate the correlation between laser-induced hearing loss and changes in the number of hair cell ribbon synapses and ultrastructure in the cochlea. Laser cochleostomy was performed with a superpulsed carbon dioxide (CO2) laser at 2 and 5 W in Sprague-Dawley rats. Auditory brainstem responses (ABRs) were measured preoperatively and 2 days after surgery. The synapse numbers in apical and middle cochlear turns were quantified. Transmission electron microscopy was employed to further examine the subcellular changes in the cochlea. Click and tonal ABR threshold shifts in both 2 and 5-W groups displayed a frequency-dependent loss within the frequency range measured. Laser cochleostomy induced a significant decrease of synapse numbers in the middle turn in both groups (p?hearing loss even under low-energy laser cochleostomy. The high-energy laser-induced hearing loss was associated with more reduction of synapse number.

Ye Q; Geng Y; Zhang XZ; Chen WL; Tian TJ; Xie SS; Huang Z

2013-08-01

270

Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english Sudden hearing loss is defined as a sensorineural hearing loss, equal to or greater than 30 dB, at three or more consecutive frequencies, which takes place within 72 hours. Both peginterferon and ribavirin are well-known to be associated with significant adverse effects, but sudden hearing loss is uncommon. We report a 65-year-old male patient who developed sudden-onset hearing loss during combination therapy with pegylated interferon-alpha and ribavirin for chronic hepat (more) itis C. Peginterferon and ribavirin may cause sudden hearing loss that may not recover after discontinuation of therapy. Immediate treatment for all possible etiologies is essential, along with targeted investigations and early referral for an Ear, Nose and Throat specialist. Physicians should be aware of the possible ototoxic effects of peginterferon and ribavirin combination therapy requiring appropriate surveillance.

Mendes-Corrêa, Maria Cassia Jacintho; Bittar, Roseli Saraiva Moreira; Salmito, Norma; Oiticica, Jeanne

2011-02-01

271

The More the Worse: the Grade of Noise-Induced Hearing Loss Associates with the Severity of Tinnitus  

Directory of Open Access Journals (Sweden)

Full Text Available Tinnitus disturbs lives and negatively affects the quality of life of about 2% of the adult world population. Research has shown that the main cause of tinnitus is hearing loss. To analyze a possible association of the degree of hearing loss with the severity of tinnitus, we have performed a retrospective study using admission data on 531 patients suffering from chronic tinnitus. We have found that 83% of our tinnitus patients had a high frequency hearing loss corresponding to a noise-induced hearing loss (NIHL). There was a significant correlation between the mean hearing loss and the tinnitus loudness (p < 0.0001). Interestingly, patients suffering from decompensated chronic tinnitus had a greater degree of hearing loss than the patients with compensated form of tinnitus. In addition, we demonstrate that the degree of hearing loss positively correlates with the two subscales (“intrusiveness” and “auditory perceptional difficulties”) of the Tinnitus Questionnaire. Our retrospective study provides indirect evidence supporting the hypothesis that the degree of noise-induced hearing loss influences the severity of tinnitus.

Birgit Mazurek; Heidi Olze; Heidemarie Haupt; Agnieszka J. Szczepek

2010-01-01

272

Hearing loss in the mining industry: overview of the NIOSH hearing loss prevention program at the Pittsburgh Research Laboratory  

Energy Technology Data Exchange (ETDEWEB)

The National Institute for Occupational Safety and Health (NIOSH) has recognised that noise-induced hearing loss (NIHL) is the most common occupational illness in the United States. The Pittsburgh Research Laboratory at NIOSH has developed a hearing loss prevention program for overcoming these respective barriers in an attempt to reduce NIHL in the mining industry. The program is comprised of four key programmatic areas: noise dose/source relationships; availability of effective noise control; worker education and empowerment; and communication issues. 13 refs., 7 figs.

Matetic, R.J. [NIOSH, Pittsburgh, PA (United States)

2005-07-01

273

Mechanisms contributing to central excitability changes during hearing loss.  

UK PubMed Central (United Kingdom)

Exposure to loud sound causes cochlear damage resulting in hearing loss and tinnitus. Tinnitus has been related to hyperactivity in the central auditory pathway occurring weeks after loud sound exposure. However, central excitability changes concomitant to hearing loss and preceding those periods of hyperactivity, remain poorly explored. Here we investigate mechanisms contributing to excitability changes in the dorsal cochlear nucleus (DCN) shortly after exposure to loud sound that produces hearing loss. We show that acoustic overexposure alters synaptic transmission originating from the auditory and the multisensory pathway within the DCN in different ways. A reduction in the number of myelinated auditory nerve fibers leads to a reduced maximal firing rate of DCN principal cells, which cannot be restored by increasing auditory nerve fiber recruitment. In contrast, a decreased membrane resistance of DCN granule cells (multisensory inputs) leads to a reduced maximal firing rate of DCN principal cells that is overcome when additional multisensory fibers are recruited. Furthermore, gain modulation by inhibitory synaptic transmission is disabled in both auditory and multisensory pathways. These cellular mechanisms that contribute to decreased cellular excitability in the central auditory pathway are likely to represent early neurobiological markers of hearing loss and may suggest interventions to delay or stop the development of hyperactivity that has been associated with tinnitus.

Pilati N; Ison MJ; Barker M; Mulheran M; Large CH; Forsythe ID; Matthias J; Hamann M

2012-05-01

274

Noise-induced hearing loss and blood pressure.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

From a group of industrial workers who had a noise-induced hearing loss of at least 30 dB at 4000 Hz 62 were randomly selected after stratification. Controls matched for age and duration of employment were also selected. Resting blood pressures were measured and audiometry was repeated. The findings...

Lees, R. E.; Roberts, J. H.

275

Diffusion-Based Model for Noise-Induced Hearing Loss  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Among several different damaging mechanisms, oxidative stress is found to play an important role in noise-induced hearing loss (NIHL). This is supported by both findings of oxidative damage after noise exposure, and the fact that upregulation of antioxidant defenses seem to reduce the ears sus...

Aas, Sverre; Tronstad, Tron Vedul

276

Audiometric notch as a sign of noise induced hearing loss  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVES—To investigate the relation between different types of exposure to noise and a classic sign of noise induced hearing loss (NIHL), the audiometric notch.?METHODS—The study sample had exposure to both continuous and impulse noise and was drawn from a population of electrical transmission wo...

McBride, D; Williams, S

277

Acrylonitrile Potentiates Noise-Induced Hearing Loss in Rat  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Acrylonitrile, one of the 50 most commonly produced industrial chemicals, has recently been identified as a promoter of noise-induced hearing loss (NIHL). This agent has the potential to produce oxidative stress through multiple pathways. We hypothesize that acrylonitrile potentiates NIHL as a conse...

Fechter, Laurence D.; Gearhart, Caroline; Shirwany, Najeeb A.

278

Middle Ear Disorders and Hearing Loss in Native Hawaiian Preschoolers.  

Science.gov (United States)

Native Hawaiian preschoolers (n=172) received a battery of tests that included pure-tone audiometry, tympanometry, acoustic reflectometry, and pneumatic otoscopy. Approximately 15% of children failed a majority of the tests. Results are discussed in comparison to other indigenous groups at risk for middle ear disorders and hearing loss.…

Pang-Ching, Glenn; And Others

1995-01-01

279

Sensorineural hearing loss after concurrent chemoradiotherapy in nasopharyngeal cancer patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Sensorineural hearing loss (SNHL) is one of the major long term side effects from radiation therapy (RT) in nasopharyngeal cancer (NPC) patients. This study aims to review the incidences of SNHL when treating with different radiation techniques. The additional ob...

Petsuksiri Janjira; Sermsree Achariyaporn; Thephamongkhol Kullathorn; Keskool Phawin; Thongyai Kanthong; Chansilpa Yaowalak

280

Cell degeneration is not a primary causer for Connexin26 (GJB2) deficiency associated hearing loss.  

UK PubMed Central (United Kingdom)

Connexin26 (Cx26, GJB2) mutations can induce congenital deafness and are responsible for ?50% of nonsyndromic hearing loss in children. Mouse models show that Cx26 deficiency induces cochlear development disorder, hair cell loss, and spiral ganglion (SG) neuron degeneration. Hair cell loss and cell degeneration have been considered as a primary causer responsible for Cx26 deficiency associated hearing loss. In this study, by coincidental examination of cochlear postnatal development with recording of auditory brainstem response (ABR) and hair cell function, we found that occurrence of hearing loss in Cx26 knockout (KO) mice was ahead of hair cell loss and cochlear cell degeneration. ABR was absent at the whole-frequency range (8-40 kHz) after birth. However, cochlear cells including SG neurons had no significant degeneration throughout postnatal development. Severe cochlear hair cell loss and SG neuron degeneration were only visible in middle and basal turns, i.e., in middle and high frequency regions, in the adult Cx26 KO mouse cochlea. Functional tests show that hair cells in Cx26 KO mice functioned normally; outer hair cells retained electromotility. These data suggest that cell degeneration is not a primary causer of Cx26 deficiency associated hearing loss. Some mechanisms other than cell degeneration, such as cochlear development disorders, may play an essential role in this common hereditary deafness.

Liang C; Zhu Y; Zong L; Lu GJ; Zhao HB

2012-10-01

 
 
 
 
281

Cell degeneration is not a primary causer for Connexin26 (GJB2) deficiency associated hearing loss.  

Science.gov (United States)

Connexin26 (Cx26, GJB2) mutations can induce congenital deafness and are responsible for ?50% of nonsyndromic hearing loss in children. Mouse models show that Cx26 deficiency induces cochlear development disorder, hair cell loss, and spiral ganglion (SG) neuron degeneration. Hair cell loss and cell degeneration have been considered as a primary causer responsible for Cx26 deficiency associated hearing loss. In this study, by coincidental examination of cochlear postnatal development with recording of auditory brainstem response (ABR) and hair cell function, we found that occurrence of hearing loss in Cx26 knockout (KO) mice was ahead of hair cell loss and cochlear cell degeneration. ABR was absent at the whole-frequency range (8-40 kHz) after birth. However, cochlear cells including SG neurons had no significant degeneration throughout postnatal development. Severe cochlear hair cell loss and SG neuron degeneration were only visible in middle and basal turns, i.e., in middle and high frequency regions, in the adult Cx26 KO mouse cochlea. Functional tests show that hair cells in Cx26 KO mice functioned normally; outer hair cells retained electromotility. These data suggest that cell degeneration is not a primary causer of Cx26 deficiency associated hearing loss. Some mechanisms other than cell degeneration, such as cochlear development disorders, may play an essential role in this common hereditary deafness. PMID:22975134

Liang, Chun; Zhu, Yan; Zong, Liang; Lu, Guang-Jin; Zhao, Hong-Bo

2012-09-11

282

Efficacy of hearing-aid based telephone strategies for listeners with moderate-to-severe hearing loss.  

UK PubMed Central (United Kingdom)

BACKGROUND: Understanding speech over the telephone when listening in noisy environments may present a significant challenge for listeners with moderate-to-severe hearing loss. PURPOSE: The purpose of this study was to compare speech recognition and subjective ratings across several hearing aid-based telephone listening strategies for individuals with moderate-to-severe sensorineural hearing loss. RESEARCH DESIGN: Speech recognition and subjective ratings were evaluated for a simulated telephone signal. The strategies evaluated included acoustic telephone, unilateral telecoil, unilateral wireless streaming, and bilateral wireless streaming. Participants were seated in a noisy room for all evaluations. STUDY SAMPLE: Eighteen adults, aged 49-88 yr, with moderate-to-severe sensorineural hearing loss participated. DATA COLLECTION AND ANALYSIS: Speech recognition scores on the Connected Speech Test were converted to rationalized arcsine units and analyzed using analysis of variance testing and Tukey post hoc analyses. Subjective ratings of ease and comfort were also analyzed in this manner. RESULTS: Speech recognition performance was poorest with acoustic coupling to the telephone and best with bilateral wireless routing. Telecoil coupling resulted in better speech recognition performance than acoustic coupling, but was significantly poorer than bilateral wireless routing. Furthermore, unilateral wireless routing and telecoil coupling generally led to similar speech recognition performance, except in lower-level background noise conditions, for which unilateral routing resulted in better performance than the telecoil. CONCLUSIONS: For people with moderate-to-severe sensorineural hearing loss, acoustic telephone listening with a hearing aid may not lead to acceptable performance in noise. Although unilateral routing options (telecoil and wireless streaming) improved performance, speech recognition performance and subjective ratings of ease and comfort were best when bilateral wireless routing was used. These results suggest that wireless routing is a potentially beneficial telephone listening strategy for listeners with moderate-to-severe hearing loss who are fitted with limited venting if the telephone signal is routed to both ears. Unilateral wireless routing may provide similar benefits to traditional unilateral telecoil. However, the newer wireless systems may have the advantage for some listeners in that they do not include some of the positioning constraints associated with telecoil use.

Picou EM; Ricketts TA

2013-01-01

283

Sensorineural Hearing Loss Associated with Occupational Noise Exposure: Effects of Age-Corrections  

Directory of Open Access Journals (Sweden)

Full Text Available Noise-induced permanent threshold shifts (NIPTS) were computed from retrospective audiometric analyses by subtracting aging effects on hearing sensitivity in sixty-eight patients with bilateral sensorineural hearing loss who reported significant occupational noise exposure histories. There were significant effects of age on NIPTS but no significant gender- or ear- differences in terms of NIPTS. The NIPTS at 2,000 Hz was found to be significantly greater than NIPTS at frequencies 500 Hz, 1,000 Hz, 4,000 Hz, and 8,000 Hz. Defined noise notches were seen in the audiograms of 38/136 (27%) ears with SNHL. Results support models that suggest interactive effects of aging and noise on sensorineural hearing loss in ears with occupational noise exposure.

Sridhar Krishnamurti

2009-01-01

284

A novel missense mutation in the connexin30 causes nonsyndromic hearing loss.  

UK PubMed Central (United Kingdom)

Dysfunctional gap junctions caused by GJB2 (CX26) and GJB6 (CX30) mutations are implicated in nearly half of nonsyndromic hearing loss cases. A recent study identified a heterozygous mutation, c.119C>T (p.A40V), in the GJB6 gene of patients with nonsyndromic hearing loss. However, the functional role of the mutation in hearing loss remains unclear. In this study, analyses of cell biology indicated that a p.A40V missense mutation of CX30 causes CX30 protein accumulation in the Golgi body rather than in the cytoplasmic membrane. The tet-on protein expression system was used for further study of mutant proteins in CX30 and CX30A40V co-expressions and in CX26 and CX30A40V co-expressions. The p.A40V missense mutation exerted a dominant negative effect on both normal CX30 and CX26, which impaired gap junction formation. Moreover, computer-assisted modeling suggested that this p.A40V mutation affects the intra molecular interaction in the hydrophobic core of Trp44, which significantly alters the efficiency of gap junction formation. These findings suggest that the p.A40V mutation in CX30 causes autosomal-dominant nonsyndromic hearing loss. These data provide a novel molecular explanation for the role of GJB6 in hearing loss.

Wang WH; Liu YF; Su CC; Su MC; Li SY; Yang JJ

2011-01-01

285

The effects of aging and hearing loss on distortion product otoacoustic emissions.  

UK PubMed Central (United Kingdom)

OBJECTIVE: We sought to demonstrate the rate of change in distortion product otoacoustic emission (DPOE) amplitude with age in relation to hearing loss in an unselected adult population. Study design and setting We conducted a cross-sectional observation study involving the Framingham Offspring Cohort. Age changes in DPOE amplitude for frequencies of f2 from 1 to 8 kHz adjusted for pure-tone threshold level were assessed by multivariate linear regression. RESULTS: The women showed a mean hearing threshold-adjusted loss in high-frequency DPOE amplitude of 0.6, 2.1, 2.6, and 1.1 dB/per decade at the f2 frequencies of 1, 2, 4, and 8 kHz, respectively. In contrast, the men showed no effect of age on the DPOE amplitude independent of hearing loss. Emissions were reduced or absent in the noise notch frequencies. The rate of change with age in DPOE amplitude was significantly less than the rate of change in pure-tone thresholds in both the men and the women. CONCLUSION: Women lose DPOE amplitude from both age and hearing threshold loss. Men lose more DPOE amplitude than do women, and the loss is proportional to the degree of loss of hearing threshold sensitivity. The differential effect whereby age-related hearing loss affects thresholds more than emissions suggests that strial atrophy may be a pathophysiologic factor. SIGNIFICANCE: The use of DPOE measures for screening and monitoring cochlear status of adult women should take into account the age, pure-tone thresholds, and noise exposure status of the subjects.

Cilento BW; Norton SJ; Gates GA

2003-10-01

286

A Prevalence Study of Hearing Loss among Primary School Children in the South East of Iran.  

UK PubMed Central (United Kingdom)

Hearing impairment substantially affects child's ability to normally acquire the spoken language. Such negative effects create problems for the child not only in terms of communication but also in terms of achievement in school as well as social and emotional growth. The aim of this research is to study the prevalence of hearing disorders and its relationship to age and gender among primary school students of Zahedan, Iran. In this cross-sectional and descriptive analytical study, 1500 students from elementary schools were screened for hearing loss. The selection of samples was performed using multistage sampling method. Primary information was obtained through direct observation, otoscopy, and audiometric and tympanometric screenings. Data was obtained and analyzed via ANOVA test. Statistical analysis showed a significant correlation between the age and the prevalence of middle ear abnormal function. Conductive hearing loss in males and females was 8.8% and 7.1%, respectively. In addition, 1% and 0.7% of male and female students, respectively, suffered from sensorineural hearing loss. Results indicated that 20.2% of students of elementary schools in Zahedan needed medical treatment for their problems. Therefore, it is recommended that the hearing screening of school-age children should be included in annual school health programs in this region.

Absalan A; Pirasteh I; Dashti Khavidaki GA; Asemi Rad A; Nasr Esfahani AA; Nilforoush MH

2013-01-01

287

Hearing loss and contributing factors among airport workers in Malaysia.  

UK PubMed Central (United Kingdom)

Sensorineural hearing loss is a common and important source of disability among the workers and often caused by occupational noise exposure. Aims of the study were to determine the prevalence and contributing factors of hearing loss among airport workers. A cross-sectional study was carried out at an airport in Malaysia. This study used stratified sampling method that involved 358 workers who were working in 3 different units between November 2008 and March 2009. Data for this study were collected by using questionnaires eliciting sociodemographic, occupational exposure history (previous and present), life-style including smoking habits and health-related data. Otoscopic and pure-tone audiometric tests were conducted for hearing assessment. Noise exposure status was categorize by using a noise logging dosimeter to obtain 8-hour Time-Weighted Average (TWA). Data was analyzed by using SPSS version 12.0.1 and EpiInfo 6.04. The prevalence of hearing loss was 33.5%. Age >40 years old (aOR 4.3, 95%CI 2.2-8.3) is the main risk factors for hearing loss followed by duration of noise exposure >5 years (aOR 2.5, 95%CI 1.4-4.7), smoking (aOR 2.1, 95%CI 1.2-3.4), duration of service >5 years (aOR 2.1, 95%CI 1.1-3.9), exposure to explosion (aOR 6.1, 95%CI 1.3-29.8), exposure to vibration (aOR 2.2, 95%CI 1.1-4.3) and working in engineering unit (aOR 5.9, 95%CI 1.1-30.9). The prevalence rate ratio of hearing loss for nonsmokers aged 40 years old and younger, smokers aged 40 years old and younger, non-smokers older than 40 years old and smokers older than 40 years old was 1.0, 1.7, 2.8 and 4.6 respectively. This result contributes towards better understanding of risk factors for hearing loss, which is relatively common among Malaysian workers.

Nasir HM; Rampal KG

2012-02-01

288

Congenital inner ear malformations without sensorineural hearing loss in children.  

UK PubMed Central (United Kingdom)

Inner ear malformations are frequently found in patients with congenital hearing loss. It has been reported that normal hearing is rare in patients with severe inner ear vestibular malformations. A 9-year-old boy had had complained of recurrent dizziness and disequilibrium for 2 months. Clinical and neuro-otological examinations showed peripheral involvement of the vestibular system, while audiological investigation was normal. High-resolution magnetic resonance imaging, with three-dimensional reconstruction, showed dysplasia of the bilateral lateral semicircular canals (LSCCs). Isolated vestibular malformation might not be as rare as previously thought, and should be examined by imaging of the temporal bone.

Ozeki M; Kato Z; Sasai H; Kubota K; Funato M; Orii K; Kaneko H; Fukao T; Kondo N

2009-10-01

289

The impact of hearing loss on the quality of life of elderly adults  

Directory of Open Access Journals (Sweden)

Full Text Available Andrea Ciorba, Chiara Bianchini, Stefano Pelucchi, Antonio PastoreENT and Audiology Department, University Hospital of Ferrara, Ferrara, ItalyAbstract: Hearing loss is the most common sensory deficit in the elderly, and it is becoming a severe social and health problem. Especially in the elderly, hearing loss can impair the exchange of information, thus significantly impacting everyday life, causing loneliness, isolation, dependence, and frustration, as well as communication disorders. Due to the aging of the population in the developed world, presbycusis is a growing problem that has been reported to reduce quality of life (QoL). Progression of presbycusis cannot be remediated; therefore, optimal management of this condition not only requires early recognition and rehabilitation, but it also should include an evaluation of QoL status and its assessment.Keywords: hearing loss, presbycusis, quality of life, elderly

Ciorba A; Bianchini C; Pelucchi S; Pastore A

2012-01-01

290

Systemic steroid reduces long-term hearing loss in experimental pneumococcal meningitis  

DEFF Research Database (Denmark)

Sensorineural hearing loss is a common complication of pneumococcal meningitis. Treatment with corticosteroids reduces inflammatory response and may thereby reduce hearing loss. However, both experimental studies and clinical trials investigating the effect of corticosteroids on hearing loss have generated conflicting results. The objective of the present study was to determine whether systemic steroid treatment had an effect on hearing loss and cochlear damage in a rat model of pneumococcal meningitis.

WorsØe, Lise; Brandt, Christian T

2010-01-01

291

Prevalence and risk factors for sensorineural hearing loss: Western Sicily overview.  

Science.gov (United States)

The objective of this work was to evaluate the prevalence of sensorineural hearing loss (SNHL) and distribution of the main risk factors associated to it focusing on their role in the development of deafness and their interaction. We performed a global audiological assessment (through TEOAE, tympanometry and ABR) in 508 infants at risk studying the main risk factors reported by Joint Committee on Infant Hearing (2007). Fifty-one infants (10.03 %) were diagnosed with SNHL (45 bilateral and 6 unilateral) with a mean hearing threshold of 87.39 ± 28.25 dB HL; family history of hearing impairment (HI) and TORCH infections indicated independent significant risk factors (P 100 dB HL) emphasizes the necessity of an early diagnosis to avoid the consequences of auditory deprivation. Craniofacial abnormalities and syndromes associated to HI showed an important relationship (P < 0.00001) with conductive hearing loss. A progressive increase was evidenced in SNHL incidence as the number of risk factors rises (from 5.12 for 2 risk factors to 28.5 % for 5 or more) with a significant difference among the groups (P = 0.049); multiple risk factors showed an additional cofactor for HL (r (2) = 0.93). Considering the high SNHL prevalence (10.03 %) in infants at risk, this study highlights the necessity to implement a neonatal hearing screening program in Western Sicily. PMID:23397062

Salvago, Pietro; Martines, Enrico; Martines, Francesco

2013-02-10

292

Auditory temporal-organization abilities in school-age children with peripheral hearing loss.  

UK PubMed Central (United Kingdom)

PURPOSE: The objective was to assess auditory sequential organization (ASO) ability in children with and without hearing loss. METHOD: Forty children 9 to 12 years old participated in the study: 12 with sensory hearing loss (HL), 12 with central auditory processing disorder (CAPD), and 16 with normal hearing. They performed an ASO task in which they were asked to recall 2, 3, and 5 verbal and nonverbal stimuli with an interstimulus interval (ISI) of 425 ms as well as sequences of 2 elements with an ISI of 20 or 1,000 ms. RESULTS: No significant difference was found between the group of children with HL and the 2 other groups on nonverbal stimuli in all testing conditions. Regardless of ISI duration or number of elements in the sequence, children with HL had significantly fewer correct responses than children with normal hearing and children with CAPD for the verbal stimuli /ba/-/da/. Children with HL had significantly better performance than children with CAPD for the verbal a/-/da/ when the number of elements in the sequence varied. CONCLUSIONS: Children with sensory HL showed impaired ASO ability when recalling verbal /ba/-/da/. Results suggest that hearing loss can induce a specific signature when processing these verbal stimuli.

Koravand A; Jutras B

2013-08-01

293

Prevalence and degree of hearing loss among males in Beaver Dam cohort: Comparison of veterans and nonveterans  

Directory of Open Access Journals (Sweden)

Full Text Available The Epidemiology of Hearing Loss Study (EHLS) conducted in Beaver Dam, Wisconsin, was a population-based study that focused on the prevalence of hearing loss among 3,753 participants between 1993 and 1995. This article reports the results of several auditory measures from 999 veteran and 590 nonveteran males 48 to 92 years of age included in the EHLS. The auditory measures included pure tone thresholds, tympanometry and acoustic reflexes, word recognition in quiet and in competing message, and the Hearing Handicap Inventory for the Elderly-Screening (HHIE-S) version. Hearing loss in the auditory domains of pure tone thresholds, word recognition in quiet, and word recognition in competing message increased with age but were not significantly different for the veterans and nonveterans. No significant differences were found between participant groups on the HHIE-S; however, regarding hearing aid usage, mixed differences were found.

Richard H. Wilson, PhD; Colleen M. Noe, PhD; Karen J. Cruickshanks, PhD; Terry L. Wiley, PhD; David M. Nondahl, MS

2010-01-01

294

Combined Intratympanic and Systemic Steroid Therapy for Poor-Prognosis Sudden Sensorineural Hearing Loss  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: The aim of this study was to evaluate the efficacy of combined intratympanic and systemic steroid therapy compared with systemic steroid therapy alone in idiopathic sudden sensorineural hearing loss (ISSNHL) patients with poor prognostic factors.     Materials and Methods: Seventy-seven patients with sudden sensorineural hearing loss (SSNHL) who had at least one poor prognostic factor (age greater than 40 years, hearing loss more than 70 db, or greater than a 2-week delay between the onset of hearing loss and initiation of therapy) were included in this study. Patients were randomized to the intervention group (combined intratympanic and systemic steroid therapy) or the control group (systemic steroid therapy alone). All patients received oral treatment with systemic prednisolone (1 mg/kg/day for 10 days), acyclovir (2 g/day for 10 days, divided into four doses), triamterene H (daily), and omeprazole (daily, during steroid treatment), and were advised to follow a low salt diet. The intervention group also received intratympanic dexamethasone injections (0.4 ml of 4 mg/ml dexamethasone) two times a week for two consecutive weeks (four injections in total). A significant hearing improvement was defined as at least a 15-db decrease in pure tone average (PTA).  Results: Among all participants, 44 patients (57.14%) showed significant improvement in hearing evaluation. More patients showed hearing improvement in the intervention group than in the control group (27 patients (75%) versus 17 patients (41.4%), respectively; P = 0.001).  Conclusion:  The combination of intratympanic dexamethasone and systemic prednisolone is more effective than systemic prednisolone alone in the treatment of poor-prognosis SSNHL.

Shima Arastou; Ardavan Tajedini; Pedram Borghei

2012-01-01

295

A cohort study of patients with tinnitus and sensorineural hearing loss in a Swedish population.  

UK PubMed Central (United Kingdom)

OBJECTIVE: We aimed to describe a large cohort of patients with tinnitus and sensorineural hearing loss (SNHL) in Sweden, and also to explore the possibility of finding potential possible differences between various diagnoses within SNHL. It is also of great interest to see how a multidisciplinary team was used in the different subgroups and the frequency of hearing aids use in patients with tinnitus. METHODS: Medical records of all patients who had received the diagnosis SNHL in Östergötland County, Sweden between 2004 and 2007 were reviewed. Patients between 20 and 80 years with tinnitus and a pure tone average (PTA) lower than 70dB HL were included in the study. Patients were excluded from the analyses if they had a cochlear implantation, middle ear disorders or had a hearing loss since birth or childhood. The investigators completed a form for each included patient, covering background facts, and audiograms taken at the yearly check up. RESULTS: Of a total 1672 patients' medical record review, 714 patients were included. The majority of patients (79%) were in the age group over 50 years. In male patients with bilateral tinnitus, the PTA for the left ear was significantly higher than for the right ear. The results regarding the configuration of hearing loss revealed that 555 patients (78%) had symmetric and 159 (22%) asymmetric hearing loss. Retrocochlear examinations were done in 372 patients and MRI was the most common examination. In all patients, 400 had no hearing aids and out of those 220 had unilateral tinnitus and 180 patients had bilateral tinnitus. 219 patients had a PTA>20dB HL and did not have any hearing aid. Results demonstrated that the Stepped Care model was not used widely in the daily practice. In our study, patients with bilateral-, unilateral hearing loss or Mb Ménière were the most common patients included in the Stepped Care model. CONCLUSION: In a large cohort of patients with SNHL and tinnitus, despite their hearing loss only 39% had hearing aids. It was observed that the medical record review often showed a lack of information about many background factors, such as; patients' general health condition, which could be a quality factor that needs improvement. Our results show that the Stepped Care model could be an effective option for providing a better access for tinnitus-focused treatment, although the number of patients in this study who were included in the Stepped Care model was low.

Zarenoe R; Ledin T

2013-02-01

296

[Risk assessment of hearing loss in orchestral musicians].  

UK PubMed Central (United Kingdom)

BACKGROUND: The aim of this study was to assess sound exposure and the risk of noise-induced hearing loss (NIHL) in orchestral musicians. MATERIALS AND METHODS: Questionnaire inquiries and sound pressure level measurements were carried out in 63 musicians. Based on these data the risk assessment of the NIHL was performed according to ISO 1999:1990 (PN-ISO 1999:1990). RESULTS: The classical orchestral musicians are usually exposed to sound at equivalent continuous A-weighted sound pressure levels of 81-90 dB (10-90th percentile), for 20-48 h (10-90th percentile) per week. Occupational exposures to such sound levels over 40 years of employment cause the risk of hearing impairment (expressed as mean hearing threshold level for 2, 3 and 4 kHz equal or greater than 25 dB) in the range of 13-33% and 9-33% in females and males, respectively. The highest risk is related to playing clarinet (up to 33%), tube (up to 34%), trumpet (up to 37%), trombone (up to 40%), percussion section (up to 41%) and horn (up to 47%). About 46% of respondents noticed hearing impairment. Nearly every fifth musician complained of tinnitus while almost half (48%) of them--of hyperacusis. However, only 14% of musicians declared present or past usage of hearing protective devices (HPDs) while over twice of them (30%) intended to use HPDs in the future.

Pawlaczyk-?uszczy?ska M; Dudarewicz A; Zamojska M; Sliwi?ska-Kowalska M

2010-01-01

297

Sensory neural hearing loss after concurrent cisplatin and radiation therapy for nasopharyngeal carcinoma  

International Nuclear Information System (INIS)

Sensory neural hearing loss (SNHL) was evaluated in the patients who were treated with concurrent chemoradiation therapy for nasopharyngeal carcinoma. Ten from 48 ears showed persistent SNHL. Radiotherapy techniques, radiation dose to inner ear and post-treatment otitis media were significant predicting factors for SNHL.

2004-01-01

298

Gray matter in the brain: differences associated with tinnitus and hearing loss.  

UK PubMed Central (United Kingdom)

Tinnitus, usually associated with hearing loss, is characterized by the perception of sound without an external sound source. The pathophysiology of tinnitus is poorly understood. In the present study, voxel-based morphometry (VBM) was employed to identify gray matter differences related to hearing loss and tinnitus. VBM was applied to magnetic resonance images of normal-hearing control subjects (n = 24), hearing-impaired subjects without tinnitus (n = 16, HI group) and hearing-impaired subjects with tinnitus (n = 31, HI + T group). This design allowed us to disentangle the gray matter (GM) differences related to hearing loss and tinnitus, respectively. Voxel-based VBM analyses revealed that both HI and HI + T groups, relative to the controls, had GM increases in the superior and middle temporal gyri, and decreases in the superior frontal gyrus, occipital lobe and hypothalamus. We did not find significant GM differences between both patient groups. Subsequent region-of-interest (ROI) analyses of all Brodmann Areas, the cerebellum and the subcortical auditory nuclei showed a GM increase in the left primary auditory cortex of the tinnitus patients compared to the HI and control groups. Moreover, GM decreases were observed in frontal areas and mainly GM increases in limbic areas, both of which occurred for hearing loss irrespective of tinnitus, relative to the controls. These results suggest a specific role of the left primary auditory cortex and the additional involvement of various non-auditory brain structures in tinnitus. Understanding the causal relation between these GM changes and tinnitus will be an important next step in understanding tinnitus mechanisms.

Boyen K; Langers DR; de Kleine E; van Dijk P

2013-01-01

299

Hearing loss and cochlear damage in experimental pneumococcal meningitis, with special reference to the role of neutrophil granulytes  

DEFF Research Database (Denmark)

Hearing loss is a well-known sequelae from meningitis, affecting up to 25% of survivors. However, the principal components of the infectious and inflammatory reaction responsible for the sensorineural hearing loss remain to be identified. The present study aimed to investigate the impact of an augmented neutrophil response on the development of hearing loss and cochlear damage in a model of experimental pneumococcal meningitis in rats. Hearing loss and cochlear damage were assessed by distortion product oto-acoustic emissions (DPOAE), auditory brainstem response (ABR) and histopathology in rats treated with ceftriaxone 28 h after infection. Rats were treated with Granulocyte Colony Stimulating Factor (G-CSF) initiated prior to infection, 28 h after infection or with ceftriaxone only. Rats were followed for 7 days, and assessment of hearing was performed before infection and 24 h and day 8 after infection. Pretreatment with G-CSF increased hearing loss 24 h after infection and on day 8 compared to untreated rats (Mann-Whitney, P = 0.012 and P = 0.013 respectively). The increased sensorineural hearing loss at day 8 was associated with significantly decreased spiral ganglion cell counts (P = 0.0006), increased damage to the organ of Corti (P = 0.007), increased areas of inflammatory infiltrates (P = 0.02) and increased white blood cell (WBC) counts in cerebrospinal fluid on day 8 after infection (P = 0.0084). Initiation of G-CSF 28 h after infection did not significantly affect hearing loss or cochlear pathology compared to controls. In conclusion, the inflammatory host reaction contributes significantly to the development of hearing loss in experimental meningitis.

Brandt, CT; Caye-Thomsen, P

2006-01-01

300

The future role of genetic screening to detect newborns at risk of childhood-onset hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To explore the future potential of genetic screening to detect newborns at risk of childhood-onset hearing loss. DESIGN: An expert led discussion of current and future developments in genetic technology and the knowledge base of genetic hearing loss to determine the viability of genetic screening and the implications for screening policy. RESULTS AND DISCUSSION: Despite increasing pressure to adopt genetic technologies, a major barrier for genetic screening in hearing loss is the uncertain clinical significance of the identified mutations and their interactions. Only when a reliable estimate of the future risk of hearing loss can be made at a reasonable cost, will genetic screening become viable. Given the speed of technological advancement this may be within the next 10 years. Decision-makers should start to consider how genetic screening could augment current screening programmes as well as the associated data processing and storage requirements. CONCLUSION: In the interim, we suggest that decision makers consider the benefits of (1) genetically testing all newborns and children with hearing loss, to determine aetiology and to increase knowledge of the genetic causes of hearing loss, and (2) consider screening pregnant women for the m.1555A> G mutation to reduce the risk of aminoglycoside antibiotic-associated hearing loss.

Linden Phillips L; Bitner-Glindzicz M; Lench N; Steel KP; Langford C; Dawson SJ; Davis A; Simpson S; Packer C

2013-02-01

 
 
 
 
301

The mitochondrion: a perpetrator of acquired hearing loss.  

Science.gov (United States)

Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably less information available as to the mechanisms underlying ROS formation. Most cellular ROS arise in mitochondria and this review will evaluate evidence for mitochondrial pathology in general and dysfunction of the mitochondrial respiratory chain in particular in acquired hearing loss. We will discuss evidence that different pathways can lead to the generation of ROS and that oxidative stress might not necessarily be causal to all three pathologies. Finally, we will detail recent advances in exploiting knowledge of aminoglycoside-mitochondria interactions for the development of non-ototoxic antibacterials. This article is part of a Special Issue entitled "Annual Reviews 2013". PMID:23361190

Böttger, Erik C; Schacht, Jochen

2013-01-27

302

MR imaging of 495 consecutive cases with sensorineural hearing loss  

International Nuclear Information System (INIS)

495 consecutive patients with SNHL and 120 age-matched healthy controls were examined. Spin-echo (SE) and fast spin-echo (FSE) images were used with 1.5 T equipment. An intracranial abnormality was found in 211 (42.6%) of the patients with 95 (19.2%) along the acoustic pathway. Eleven of the 95 patients had sensory hearing loss while 84 had neural hearing loss with the retrocochlear auditory pathway affected by lesions. In 62 of the 84 patients, the internal acoustic canal and cerebellopontine angle were involved. Twenty-two patients had intra-axial lesions. The controls had no pathologic changes along the auditory pathway. (orig./UG).

1995-01-01

303

Bilateral hearing loss after dichloromethane poisoning: A case report.  

UK PubMed Central (United Kingdom)

Dichloromethane is a widely used organic solvent. Occupational exposure to dichloromethane is frequent and can result in both acute and chronic toxicity, affecting mostly the central nervous system, directly or through its metabolite, carbon monoxide. The effects of dichloromethane on the peripheral nervous system are debated. Here we report the case of a 37-year-old woman who was accidentally exposed to dichloromethane. In the days following the incident she experienced bilateral hypoacusis. Hearing loss regressed after 25 days treatment with hyperbaric oxygen. This is the first report of sudden hearing loss after acute exposure to dichloromethane, suggesting a possible toxic effect of this solvent on the auditory system. Am. J. Ind. Med. 2013. © 2013 Wiley Periodicals, Inc.

Bonfiglioli R; Carnevali L; Di Lello M; Violante FS

2013-09-01

304

[Susac syndrome as a cause of sensorineural hearing loss  

UK PubMed Central (United Kingdom)

Susac's syndrome is an extremely rare clinical manifestation characterized by the triad of fluctuating sensorineural hearing loss, sudden visual loss and encephalopathy. Probably underdiagnosed, it affects young women who start the clinical history with headache, visual and hearing disturbances, with neurological findings in MRI. With unknown aetiology, pathogenesis is based on arteriolar microinfarcts in retina, cochlea, and grey and white matter in the brain. Treatment is, as stated in the bibliography and our experience, intravenous high doses of steroids followed by oral steroids together with hyperbaric oxygen to minimize ischaemic lesions. Aspirin associate to nimodipine has been useful to date in the treatment of our patient. We present a case and review the existing literature.

Cubillana Herrero JD; Soler Valcárcel A; Albaladejo Devis I; Rodríguez González-Herrero B; Minguez Merlos N; Jiménez Cervantes-Nicolás JA

2002-05-01

305

Prevalence and risk factors for sensorineural hearing loss: Western Sicily overview.  

UK PubMed Central (United Kingdom)

The objective of this work was to evaluate the prevalence of sensorineural hearing loss (SNHL) and distribution of the main risk factors associated to it focusing on their role in the development of deafness and their interaction. We performed a global audiological assessment (through TEOAE, tympanometry and ABR) in 508 infants at risk studying the main risk factors reported by Joint Committee on Infant Hearing (2007). Fifty-one infants (10.03 %) were diagnosed with SNHL (45 bilateral and 6 unilateral) with a mean hearing threshold of 87.39 ± 28.25 dB HL; family history of hearing impairment (HI) and TORCH infections indicated independent significant risk factors (P < 0.00001 and P = 0.024, respectively). High SNHL percentages were evidenced also in NICU babies, due to the various pathologies and risk factors presented by these infants, and among newborns who suffered from hyperbilirubinemia (11.97 and 9.52 %, respectively). The mean degree of hearing loss for children with family history of HI (>100 dB HL) emphasizes the necessity of an early diagnosis to avoid the consequences of auditory deprivation. Craniofacial abnormalities and syndromes associated to HI showed an important relationship (P < 0.00001) with conductive hearing loss. A progressive increase was evidenced in SNHL incidence as the number of risk factors rises (from 5.12 for 2 risk factors to 28.5 % for 5 or more) with a significant difference among the groups (P = 0.049); multiple risk factors showed an additional cofactor for HL (r (2) = 0.93). Considering the high SNHL prevalence (10.03 %) in infants at risk, this study highlights the necessity to implement a neonatal hearing screening program in Western Sicily.

Salvago P; Martines E; Martines F

2013-02-01

306

[A case of adult meningitis with bilateral sensorineural hearing loss at the onset].  

Science.gov (United States)

Here we report a case of pneumococcal meningitis with bilateral sensorineural hearing loss at the onset. The patient was a 60-year-old man who a few days before visiting our hospital experienced common cold-like symptoms, and then he suddenly developed bilateral hearing loss. Examination of the cerebrospinal fluid (CSF) on the day of admission revealed pleocytosis and his CSF culture demonstrated pneumococci. Otorhinolaryngological examinations disclosed bilateral severe sensorineural hearing loss due to cochlear impairment. Many cases of bacterial meningitis concomitant with hearing loss have been reported, but a case of meningitis starting with sudden hearing loss is rare. PMID:9396367

Hara, K; Ohno, M; Akisada, T; Yasuda, T; Terao, A

1997-07-01

307

[A case of adult meningitis with bilateral sensorineural hearing loss at the onset  

UK PubMed Central (United Kingdom)

Here we report a case of pneumococcal meningitis with bilateral sensorineural hearing loss at the onset. The patient was a 60-year-old man who a few days before visiting our hospital experienced common cold-like symptoms, and then he suddenly developed bilateral hearing loss. Examination of the cerebrospinal fluid (CSF) on the day of admission revealed pleocytosis and his CSF culture demonstrated pneumococci. Otorhinolaryngological examinations disclosed bilateral severe sensorineural hearing loss due to cochlear impairment. Many cases of bacterial meningitis concomitant with hearing loss have been reported, but a case of meningitis starting with sudden hearing loss is rare.

Hara K; Ohno M; Akisada T; Yasuda T; Terao A

1997-07-01

308

Functional Evaluation of GJB2 Variants in Nonsyndromic Hearing Loss  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Mutations in the gap junction ?2 (GJB2) gene, encoding the connexin26 (CX26) protein, are the most common cause of non-syndromic hearing loss (HL) in many populations. In the East Asian population, two variants, p.V27I (c.79G>A) and p.E114G (c.341G>A), are considered benign polymorphisms since these...

Choi, Soo-Young; Lee, Kyu Yup; Kim, Hyun-Jin; Kim, Hyo-Kyeong; Chang, Qing; Park, Hong-Joon; Jeon, Chang-Jin; Lin, Xi

309

Genetics of hearing loss: where are we standing now?  

Science.gov (United States)

Hearing loss (HL) is the most common sensory impairment and is caused by a broad range of inherited to environmental causes. Inherited HL consists 50-60% of all HL cases. The inherited form of HL is further classified to different categories. More than 300 syndromes and 40 genes have been identified to result in different levels of HL. Although several diagnostic or screening tests have been developed, yet there are controversies around their use. PMID:22218850

Mahboubi, Hossein; Dwabe, Sami; Fradkin, Matthew; Kimonis, Virginia; Djalilian, Hamid R

2012-01-05

310

Nasopharyngeal amyloidosis: an unusual cause of unilateral hearing loss  

Science.gov (United States)

Amyloidosis is typically a systemic depositional disease, diagnosed on clinical symptoms and signs in conjunction with histopathology. When occurring on a localized basis in the head and neck, the lesion is most commonly observed in the larynx. Primary localized nasal amyloidosis however is an uncommon finding, with 25 reported cases in the literature to date. We present the case of a young woman presenting with primary localized nasal amyloidosis secondary to the curious symptoms of unilateral hearing loss.

Mirza, A.H.; El-Shunnar, Suliman; Sama, Anshul

2013-01-01

311

Genetics of hearing loss: where are we standing now?  

UK PubMed Central (United Kingdom)

Hearing loss (HL) is the most common sensory impairment and is caused by a broad range of inherited to environmental causes. Inherited HL consists 50-60% of all HL cases. The inherited form of HL is further classified to different categories. More than 300 syndromes and 40 genes have been identified to result in different levels of HL. Although several diagnostic or screening tests have been developed, yet there are controversies around their use.

Mahboubi H; Dwabe S; Fradkin M; Kimonis V; Djalilian HR

2012-07-01

312

Hearing loss and kidney dysfunction: finding a unifying diagnosis.  

UK PubMed Central (United Kingdom)

Microscopic polyangiitis (MPA) is a systemic vasculitis that affects small caliber vessels, with renal and lung compromise. Diagnosis can be challenging; timely diagnosis and treatment are important to prevent devastating complication, particularly renal failure. We present a case of a patient with microscopic polyangiitis presented with renal and pulmonary involvements with concomitant sensorineural hearing loss. We provide diagnostic, therapeutic, and prognostic keys to microscopic polyangiitis.

Iruku P; Karanth P; Tiu H; Kankam C; Shaheen K

2013-01-01

313

Sensorineural hearing loss--a common finding in early-onset type 2 diabetes mellitus.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate the prevalence and potential associations of hearing impairment in patients 30 to 50 years old with diabetes diagnosed before age 40 years-early-onset type 2 diabetes mellitus (T2DM). METHODS: The study cohorts consisted of 46 consecutive patients with early-onset T2DM and 47 age-matched control subjects with rheumatoid arthritis. All study subjects completed clinical, serologic, and auditory assessments. RESULTS: The patients with T2DM had a mean age of 42 ± 6 years and a mean disease duration of 11 ± 6 years. Microalbuminuria was present in 26.1%, proliferative retinopathy in 26.1%, and symptomatic peripheral neuropathy in 23.9%. The prevalence of unilateral or bilateral hearing loss was significantly higher in the patients with T2DM than in the patients with rheumatoid arthritis (21.7% versus 6.4%, respectively; P = .01). Most cases of hearing loss were mild and involved high or acute tones. After multivariate analysis with adjustment for age, there was a significant association between hearing loss and hemoglobin A1c (odds ratio, 1.3; 95% confidence interval, 1.02 to 1.81; P = .035). In the patients with T2DM, the lengthening of the brainstem response was not significantly increased; however, the wave morphologic features were abnormal and the reproducibility was poor in both ears in 11 patients (24%). CONCLUSION: Patients with early-onset T2DM and poor glycemic control have an increased prevalence of subclinical hearing loss and impaired auditory brainstem responses. Hearing impairment may be an underrecognized complication of diabetes.

Lerman-Garber I; Cuevas-Ramos D; Valdés S; Enríquez L; Lobato M; Osornio M; Escobedo AR; Pascual-Ramos V; Mehta R; Ramírez-Anguiano J; Gómez-Pérez FJ

2012-07-01

314

Subgroups of enlarged vestibular aqueduct in relation with SLC26A4 mutations and hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To investigate possible association of hearing loss and SLC26A4 mutations with the subgroups of enlarged vestibular aqueduct (EVA) morphology in Japanese subjects with hearing loss. STUDY DESIGN: Retrospective multi-center study. METHODS: Forty-seven subjects who had vestibular aqueduct with midpoint diameter greater than 1 mm by CT of the temporal bone were enrolled at multiple sites across Japan, and DNA samples and clinical data were collected. EVA morphology was classified into four subgroups by the pattern of enlargement: aperture, aperture & midpoint, midpoint, and borderline enlargement. Venous blood DNA samples were subjected to PCR-based direct sequencing of all exons and exon-intron boundaries of the SLC26A4 gene. RESULTS: Four novel SLC26A4 mutations were identified in the present study. SLC26A4 mutations were detected in almost all subjects with aperture, aperture & midpoint, and midpoint enlargement. In contrast, 71% of subjects with borderline enlargement had no SLC26A4 mutation. No significant difference was found in the distribution of truncating and non-truncating SLC26A4 mutations between the EVA subgroups. In addition, no significant correlation was observed between the EVA subgroups and the hearing levels, incidence of hearing fluctuation, or progression of hearing loss. CONCLUSION: Subgroups of EVA morphology were significantly correlated with the presence or absence of SLC26A4 mutation. In a subgroup analysis of subjects with SLC26A4 mutations, however, differences in the EVA subgroups were not correlated with SLC26A4 genotypes or characteristics of hearing loss.

Okamoto Y; Mutai H; Nakano A; Arimoto Y; Sugiuchi T; Masuda S; Morimoto N; Sakamoto H; Ogahara N; Takagi A; Taiji H; Kaga K; Ogawa K; Matsunaga T

2013-09-01

315

[DPOAE in tinnitus patients with cochlear hearing loss considering hyperacusis and misophonia].  

UK PubMed Central (United Kingdom)

UNLABELLED: The most probable place generating tinnitus in auditory pathway are outer hair cells (OHC) inside cochlea. To asses their activity otoacoustic emission is used. The goal of the investigation was estimation the features of otoemission DPOAE in groups with tinnitus patients with cochlear hearing loss, estimation of diagnostic value of DPOAE parameters for analysis of function of the cochlea in investigated patients emphasizing DPOAE parameters most useful in localizing tinnitus generators and estimation of hypothetic influence of hyperacusis and misophony on parameters of DPOAE in tinnitus patients with cochlear hearing loss. The material of the study were 42 tinnitus patients with cochlear hearing loss. In the control group there were 21 patients without tinnitus with the same type of hearing loss. Then tinnitus patients were divided into three subgroups--with hyperacusis, misophony and without both of them, based on audiologic findings. METHOD: after taking view on tinnitus and physical examination in all the patients pure tone and impedance audiometry, supratreshold tests, ABR and audiometric average and discomfort level were evaluated. Then otoemission DPOAE was measured in three procedures. First the amplitudes of two points per octave were assessed, in second--"fine structure" method-- 16-20 points per octave (f2/f1 = 1.2, L1 = L2 = 70 dB). Third procedure included recording of growth rate function in three series for input tones of value f2 = 2002, 4004, 6006 Hz (f2/f1= 1.22) and levels L1=L2, growing by degrees of 5dB in each series. RESULTS: DPOAE amplitudes in recording of 2 points per octave and fine structure method are very valuable parameters for estimation of cochlear function in tinnitus patients with cochlear hearing loss. Decreasing of DPOAE amplitudes in patients with cochlear hearing loss and tinnitus suggests significant role of OHC pathology, unbalanced by IHC injury in generation of tinnitus in patients with hearing loss of cochlear localization. DPOAE fine structure provides us the additional information about DPOAE amplitude recorded in two points per octave, spreading the amount of frequencies f2, where differences are noticed in comparison of two groups--tinnitus patients and control. Function growth rate cannot be the only parameter in estimation of DPOAE in tinnitus patients with cochlear hearing loss, also including subjects with hyperacusis and misophony. Hyperacusis has important influence on DPOAE amplitude, increases essentially amplitude of DPOAE in the examined group of tinnitus patients.

Sztuka A; Po?piech L; Gawron W; Dudek K

2006-01-01

316

Pure tone audiograms and possible aminoglycoside-induced hearing loss in belugas (Delphinapterus leucas)  

Science.gov (United States)

A behavioral response paradigm was used to measure pure-tone hearing sensitivities in two belugas (Delphinapterus leucas). Tests were conducted over a 20-month period at the Point Defiance Zoo and Aquarium, in Tacoma, WA. Subjects were two males, aged 8-10 and 9-11 during the course of the study. Subjects were born in an oceanarium and had been housed together for all of their lives. Hearing thresholds were measured using a modified up/down staircase procedure and acoustic response paradigm where subjects were trained to produce audible responses to test tones and to remain quiet otherwise. Test frequencies ranged from approximately 2 to 130 kHz. Best sensitivities ranged from approximately 40 to 50 dB re 1 ?Pa at 50-80 kHz and 30-35 kHz for the two subjects. Although both subjects possessed traditional ``U-shaped'' mammalian audiograms, one subject exhibited significant high-frequency hearing loss above 37 kHz compared to previously published data for belugas. Hearing loss in this subject was estimated to approach 90 dB for frequencies above 50 kHz. Similar ages, ancestry, and environmental conditions between subjects, but a history of ototoxic drug administration in only one subject, suggest that the observed hearing loss was a result of the aminoglycoside antibiotic amikacin. .

Finneran, James J.; Carder, Donald A.; Dear, Randall; Belting, Traci; McBain, Jim; Dalton, Les; Ridgway, Sam H.

2005-06-01

317

The role of mitochondrial DNA mutations in hearing loss.  

UK PubMed Central (United Kingdom)

Mutations in mitochondrial DNA (mtDNA) are one of the most important causes of hearing loss. Of these, the homoplasmic A1555G and C1494T mutations at the highly conserved decoding site of the 12S rRNA gene are well documented as being associated with either aminoglycoside-induced or nonsyndromic hearing loss in many families worldwide. Moreover, five mutations associated with nonsyndromic hearing loss have been identified in the tRNA(Ser(UCN)) gene: A7445G, 7472insC, T7505C, T7510C, and T7511C. Other mtDNA mutations associated with deafness are mainly located in tRNA and protein-coding genes. Failures in mitochondrial tRNA metabolism or protein synthesis were observed from cybrid cells harboring these primary mutations, thereby causing the mitochondrial dysfunctions responsible for deafness. This review article provides a detailed summary of mtDNA mutations that have been reported in deafness and further discusses the molecular mechanisms of these mtDNA mutations in deafness expression.

Ding Y; Leng J; Fan F; Xia B; Xu P

2013-08-01

318

The role of mitochondrial DNA mutations in hearing loss.  

Science.gov (United States)

Mutations in mitochondrial DNA (mtDNA) are one of the most important causes of hearing loss. Of these, the homoplasmic A1555G and C1494T mutations at the highly conserved decoding site of the 12S rRNA gene are well documented as being associated with either aminoglycoside-induced or nonsyndromic hearing loss in many families worldwide. Moreover, five mutations associated with nonsyndromic hearing loss have been identified in the tRNA(Ser(UCN)) gene: A7445G, 7472insC, T7505C, T7510C, and T7511C. Other mtDNA mutations associated with deafness are mainly located in tRNA and protein-coding genes. Failures in mitochondrial tRNA metabolism or protein synthesis were observed from cybrid cells harboring these primary mutations, thereby causing the mitochondrial dysfunctions responsible for deafness. This review article provides a detailed summary of mtDNA mutations that have been reported in deafness and further discusses the molecular mechanisms of these mtDNA mutations in deafness expression. PMID:23605717

Ding, Yu; Leng, Jianhang; Fan, Fan; Xia, Bohou; Xu, Pan

2013-04-21

319

[Asymmetrical hearing loss following symmetrical acute acoustic trauma].  

Science.gov (United States)

Due to diffraction, acute acoustic trauma usually causes symmetrical hearing loss. Acoustical shadow effects are relevant only at distances greater than 1 m to the sound source and frequencies greater than 1000 Hz. In case of pronounced asymmetrical hearing loss causal connection to acute acoustic trauma is unlikely. We describe two cases with pronounced asymmetrical hearing loss in spite of symmetrical acute acoustic trauma. In the first case two patients headed an exploding giant tyre in a distance of approximately 1-2 m. One of them--as expected--got a symmetrical inner ear damage. On the other hand the other patient, which stayed directly besides him, got a pronounced asymmetrical inner ear damage. In an additional case we found also asymmetrical inner ear damage after symmetrical noise exposure. In this case it was detected, that years ago the patient suffered from a menieriform attack in the now worse ear. Occult inner ear damage is discussed as a reason for the phenomenon of pronounced asymmetrical inner ear damage after symmetrical noise exposure. PMID:17497600

Neuburger, J; Kinkel, M; Lenarz, T; Lesinski-Schiedat, A

2007-05-11

320

[Asymmetrical hearing loss following symmetrical acute acoustic trauma  

UK PubMed Central (United Kingdom)

Due to diffraction, acute acoustic trauma usually causes symmetrical hearing loss. Acoustical shadow effects are relevant only at distances greater than 1 m to the sound source and frequencies greater than 1000 Hz. In case of pronounced asymmetrical hearing loss causal connection to acute acoustic trauma is unlikely. We describe two cases with pronounced asymmetrical hearing loss in spite of symmetrical acute acoustic trauma. In the first case two patients headed an exploding giant tyre in a distance of approximately 1-2 m. One of them--as expected--got a symmetrical inner ear damage. On the other hand the other patient, which stayed directly besides him, got a pronounced asymmetrical inner ear damage. In an additional case we found also asymmetrical inner ear damage after symmetrical noise exposure. In this case it was detected, that years ago the patient suffered from a menieriform attack in the now worse ear. Occult inner ear damage is discussed as a reason for the phenomenon of pronounced asymmetrical inner ear damage after symmetrical noise exposure.

Neuburger J; Kinkel M; Lenarz T; Lesinski-Schiedat A

2007-12-01

 
 
 
 
321

Brain-stem auditory evoked responses during microvascular decompression for trigeminal neuralgia: Predicting post-operative hearing loss  

Directory of Open Access Journals (Sweden)

Full Text Available Context: The importance of brainstem auditory evoked potential monitoring in reducing hearing loss during microvascular decompression for trigeminal neuralgia is now accepted. However the extent of the changes in the pattern of these potentials and the safe limits to which these changes are relevant in reducing postoperative hearing loss have not been established. Aims: The aim of this study is to quantify these changes and relate these to the postoperative hearing loss. Settings and Design: This study was done at the Walton Centre for neurology and neurosurgery, Liverpool, United Kingdom. The study was designed to give a measure of the change in the wave pattern following microvascular decompression and relate it to postoperative hearing loss. Materials and Methods: Seventy-five patients undergoing microvascular decompression for trigeminal neuralgia had preoperative and postoperative hearing assessments and intraoperative brainstem auditory evoked potential monitoring. Statistical Analysis Used: Chi-square tests. Results: It was found that the wave V latency was increased by more than 0.9ms in nine patients, eight of whom suffered significant postoperative hearing loss as demonstrated by audiometry. It was also seen that progressive decrease in amplitude of wave V showed progressive hearing loss with 25% loss when amplitude fell by 50 and 100% loss when wave V was lost completely. However most of the patients did not have a clinically manifest hearing loss. Conclusions: A per-operative increase in the latency of wave V greater than 0.9 ms and a fall of amplitude of wave V of more than 50% indicates a risk to hearing.

Ramnarayan Ramachandran; Mackenzie Ian

2006-01-01

322

Studies on hearing loss in a community with endemic cretinism in Central Java, Indonesia.  

UK PubMed Central (United Kingdom)

An audiometric study was carried out in a community of 642 subjects severly affected by endemic goitre and cretinism. Hearing loss was measured in 34 out of 41 subjects diagnosed as cretins, 92 normal subjects aged 5-20 years from the same community and 54 subjects (also of 5-20 years) living in a nearby control area without endemic goitre. The excess number of hearing defects in the endemic area seems to be entirely due to the process that leads to cretinism. There is no reason to describe deafness and deafmutism in an area with severe endemic goitre as a separate entity. The hearing defect showed a definite greater loss in the higher frequencies than in the lower frequencies and was found in 92% of the cretins. Deafmutism was present in 5, a loss of more than 60 db in 8, a loss of 40-60 db in 10 cretins. A loss of 20-30 db was found in 2.2% of normal subjects in the endemic area and 1.8% of those living in the control area. It is concluded that audiometry is a simple and significant test to establish the presence of the neurological form of endemic cretinism, which is the most prevalent form in most endemias. The differential diagnosis and pathogenesis of the described hearing defect are discussed.

Goslings BM; Djokomoeljanto R; Hoedijono R; Soepardjo H; Querido A

1975-04-01

323

Total implantation of the Implex TICA hearing amplifier implant for high frequency sensorineural hearing loss: the Tubingen University experience.  

UK PubMed Central (United Kingdom)

Hearing devices may be classified as sound-producing hearing aids, electrically stimulating devices, and vibratory hearing aids. Because patients may lose physiologic cochlear amplification, hearing devices for the treatment of sensorineural hearing loss are used as signal amplifiers. The totally implantable communication assistance (TICA) device is a European-approved totally implantable vibratory amplifier implant. It picks up the sound signal transcutaneously from the external auditory canal near the eardrum, amplifies the signal, and transduces the signal into microvibrations that are delivered to the ossicular chain.

Zenner HP; Leysieffer H

2001-04-01

324

Association between phenotype, performance with hearing aids, and genotype of childhood hearing loss in children with and without genetic alteration.  

UK PubMed Central (United Kingdom)

PURPOSE: To establish the frequency of genetic mutations related to sensorineural hearing loss (SNHL); to verify if there is association between the degree of SNHL and the presence of genetic alteration; and to verify if the Minimal Response Levels (MRL) with hearing aids vary according to the genetic alteration. METHODS: Thirty hearing aids users with ages between 8 and 111 months were evaluated. The evaluation procedures used were: pure-tone audiometry; the auditory steady state response (ASSR) on sound field, with and without hearing aids; and genetic study of the hearing loss. RESULTS: Three genetic mutations were diagnosed: 35delG, A1555G and A827G, and the children with these mutations showed higher degree of SNHL. There was no difference between the genetic patterns regarding the degree of SNHL, except for patients with A827G mitochondrial mutation, because all subjects with this mutation had profound SNHL. The difference between the MRL obtained with and without amplification, considering the presence of mutation and the degree of SNHL, was higher in children with moderate SNHL without genetic alterations, both in behavioral and electrophysiological evaluations. CONCLUSION: Genetic mutations were found in 36.7% of the sample, justifying the importance of genetic tracking in the hearing habilitation process. Children with genetic mutations showed higher degrees of hearing loss. The different mutation patterns do not directly determine the degree of hearing loss. The best thresholds with amplification were found in children with moderate hearing loss without genetic alterations.

Biaggio EP; Azevedo MF; Iório MC; Svidnicki MC; Satorato EL

2012-01-01

325

[Multi-center study of clinical treatment on the flat type of sudden hearing loss].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To investigate the effect of different treatment options for the flat type of sudden hearing loss. METHODS: Prospective, multi-center clinical study was carried out using internationally used standardized clinical research method. Patients with the flat type of sudden hearing loss between 18 and 65 years old, within two weeks duration, and without any medical treatment were recruited. Treatment options were randomly selected according to the designed random table. RESULTS: From August 2007 to October 2011, 402 patients with the flat type of sudden hearing loss who met the criteria (account for 39.26% of the total number of patients) from the 33 hospitals were collected; the total effective rate was 82.59%, and no significant difference was detected between different treatments, (?(2) = 10.95, P = 0.28). In the 402 cases, 139 were cured (34.58%); 118 were markedly improved (29.35%); 75 were effective (18.66%); 70 were invalid (17.41%). CONCLUSIONS: The therapeutic efficacy of flat type of sudden hearing loss overall is good; the treatment of improving the inner ear blood rheology and/or reducing blood fibrinogen has clinical significance; the therapeutic efficacy of using glucocorticoid systemically is good as well; there is no obvious difference between combination and single medication.

Chen GH; Zhang R; Wang YG; Ye SN; Lin C; Cheng JM; Qiu JX; Wu KL; Yu DZ; Tong BS

2013-05-01

326

Bilateral Bone Conduction Devices: Improved Hearing Ability in Children With Bilateral Conductive Hearing Loss.  

UK PubMed Central (United Kingdom)

OBJECTIVES:: The aim of the study was to investigate whether children with bilateral conductive hearing loss benefit from their second device (i.e., the bilateral bone conduction device [BCD]). DESIGN:: Speech recognition in noise was assessed in 10 children fitted with bilateral BCDs during childhood. Speech recognition was measured in 2 conditions with both BCDs active. Spatial resolution was tested with the Minimum Audible Angle test in the bilateral and monaural listening conditions. RESULTS:: Children demonstrated an improvement in speech recognition when speech was presented from the front and noise was presented from the right-hand side as compared with both speech and noise being presented from the front. The minimum audible angle decreased from 57° in the best monaural condition to 13° in the bilateral condition. CONCLUSIONS:: The audiological outcomes demonstrate the advantage of bilateral BCD fitting in children with bilateral conductive hearing loss.

Dun CA; Agterberg MJ; Cremers CW; Hol MK; Snik AF

2013-05-01

327

Bilateral Bone Conduction Devices: Improved Hearing Ability in Children With Bilateral Conductive Hearing Loss.  

Science.gov (United States)

OBJECTIVES:: The aim of the study was to investigate whether children with bilateral conductive hearing loss benefit from their second device (i.e., the bilateral bone conduction device [BCD]). DESIGN:: Speech recognition in noise was assessed in 10 children fitted with bilateral BCDs during childhood. Speech recognition was measured in 2 conditions with both BCDs active. Spatial resolution was tested with the Minimum Audible Angle test in the bilateral and monaural listening conditions. RESULTS:: Children demonstrated an improvement in speech recognition when speech was presented from the front and noise was presented from the right-hand side as compared with both speech and noise being presented from the front. The minimum audible angle decreased from 57° in the best monaural condition to 13° in the bilateral condition. CONCLUSIONS:: The audiological outcomes demonstrate the advantage of bilateral BCD fitting in children with bilateral conductive hearing loss. PMID:23698625

Dun, Catharina A J; Agterberg, Martijn J H; Cremers, Cor W R J; Hol, Myrthe K S; Snik, Ad F M

2013-05-21

328

Molecular and hereditary mechanisms of sensorineural hearing loss with focus on selected endocrinopathies.  

Science.gov (United States)

Hearing loss is one of the most widespread sensory disorders. The incidence of deafness in general population is 1:1000 newborns. About one half of the cases of the congenital sensorineural hearing loss (SNHL) is inherited. Recessive mutations in the gap junction beta 2 (GJB2) gene are the most common genetic causes of the nonsyndromic SNHL. The GJB2 encodes a protein connexin 26 which forms a subunit of gap junction essential for the correct function of the inner ear. The syndromic SNHL is associated with a wide range of other symptoms, which encompass also dysfunctions of endocrine organs. The Pendred syndrome associated with the hearing impairment is characterized by a prelingual, bilateral sever to profound SNHL, goiter, and iodine organification defect. It is an autosomal recessive disorder, which develops due to mutations in pendrin, an anion channel encoded by SLC26A4 gene. Another important type of syndromic hearing loss is the Maternally Inherited Diabetes and Deafness syndrome, which is caused by several mitochondrial DNA mutations. These mutations are clinically manifested by a hearing impairment with development of the diabetes in the adult age. Hearing impairment occurs during puberty when sensation of high frequency tones is affected following with further progress to profound bilateral sensorineural hearing impairment in the whole frequency range. This review deals with the molecular mechanisms of common genetic causes of the hereditary SNHL along with the selected endocrinopathies emphasizing that the DNA analyses along with the functional studies significantly contribute to the early SNHL diagnosis followed by personalized therapy and genetic counseling. PMID:22808909

Masindova, I; Varga, L; Stanik, J; Valentinova, L; Profant, M; Klimes, I; Gasperikova, D

2012-07-01

329

Molecular and hereditary mechanisms of sensorineural hearing loss with focus on selected endocrinopathies.  

UK PubMed Central (United Kingdom)

Hearing loss is one of the most widespread sensory disorders. The incidence of deafness in general population is 1:1000 newborns. About one half of the cases of the congenital sensorineural hearing loss (SNHL) is inherited. Recessive mutations in the gap junction beta 2 (GJB2) gene are the most common genetic causes of the nonsyndromic SNHL. The GJB2 encodes a protein connexin 26 which forms a subunit of gap junction essential for the correct function of the inner ear. The syndromic SNHL is associated with a wide range of other symptoms, which encompass also dysfunctions of endocrine organs. The Pendred syndrome associated with the hearing impairment is characterized by a prelingual, bilateral sever to profound SNHL, goiter, and iodine organification defect. It is an autosomal recessive disorder, which develops due to mutations in pendrin, an anion channel encoded by SLC26A4 gene. Another important type of syndromic hearing loss is the Maternally Inherited Diabetes and Deafness syndrome, which is caused by several mitochondrial DNA mutations. These mutations are clinically manifested by a hearing impairment with development of the diabetes in the adult age. Hearing impairment occurs during puberty when sensation of high frequency tones is affected following with further progress to profound bilateral sensorineural hearing impairment in the whole frequency range. This review deals with the molecular mechanisms of common genetic causes of the hereditary SNHL along with the selected endocrinopathies emphasizing that the DNA analyses along with the functional studies significantly contribute to the early SNHL diagnosis followed by personalized therapy and genetic counseling.

Masindova I; Varga L; Stanik J; Valentinova L; Profant M; Klimes I; Gasperikova D

2012-07-01

330

The effect of mild hearing loss on academic performance in primary school children.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To determine the prevalence of mild hearing loss and its association with academic performance among primary school children. PATIENTS AND METHODS: A comparative cross sectional study was conducted on standard (grade) five school children in a state in Malaysia. Five schools were selected by using simple random sampling. There were three classes (A, B and C) of standard five in each school. Student's selection into these classes was made by respective school administration based on their final term examination in standard four. Class A was for the best academic achievers while class C was for the poorest. Ear examinations were done followed by pure tone audiometry for confirmation of the hearing status. In this study, mild hearing loss was defined as an average threshold of 20-39 dB at 0.5, 1, 2 and 4 kHz. Data analysis was done using SPSS Version 12.0 software. Chi-square test was used to determine the association between mild hearing loss and academic performance. The significant level was set at p=0.05. RESULTS: From a total of 257 students, 234 have completed the examinations (response rate=91.0%). Fifty-three percent of them were boys while 47% were girls. A hundred and forty-nine (63.7%) of them were from class A while 85 (36.3%) were from class C. The prevalence of hearing loss in our school population was 15% (95% CI: 11.0-20.0%). Thirty-two (88.9%) of them were having conductive type. Out of the total, 38.9% were having problems in both ears. The students who have poor academic performance have been shown to be significantly associated with mild hearing loss (p<0.001). CONCLUSIONS: There was a high prevalence of mild hearing loss among primary school children. This problem could affect their academic performance. Therefore, hearing assessment is highly recommended to be done on every child especially to those who have poor academic achievement.

Khairi Md Daud M; Noor RM; Rahman NA; Sidek DS; Mohamad A

2010-01-01

331

Hearing loss and heavy metal toxicity in a Nicaraguan mining community: audiological results and case reports.  

UK PubMed Central (United Kingdom)

We measured fingernail metal levels, Békésy-type pure-tone thresholds and distortion product otoacoustic emission (DPOAE) levels in 59 subjects residing in the gold mining community of Bonanza, Nicaragua. Auditory testing revealed widespread hearing loss in the cohort. Nail metal concentrations (mercury, lead, aluminum, manganese and arsenic) far exceeded reference levels. No relationship was found between metal levels and auditory test results for the group as a whole. Statistically significant relationships were found between DPOAE response amplitudes and metal concentrations in a subgroup with less than 40 h per week of significant noise exposure; however, conclusions regarding these relationships should be tempered by the large number of analyses performed. Several young individuals with high metal levels reported neurological symptoms and had poor hearing. The data suggest that metal levels in artisanal mining communities present a significant public health problem and may affect hearing.

Saunders JE; Jastrzembski BG; Buckey JC; Enriquez D; MacKenzie TA; Karagas MR

2013-01-01

332

Auditory function and hearing loss in children and adults with Williams syndrome: cochlear impairment in individuals with otherwise normal hearing.  

UK PubMed Central (United Kingdom)

Hearing loss is common in school-age individuals with Williams syndrome (WS) and extensive in adults. Prior studies with relatively small sample sizes suggest that hearing loss in WS has an early onset and may be progressive, yet the auditory phenotype and the scope of the hearing loss have not been adequately characterized. We used standard audiometric tools: Otoscopy, tympanometry, air-conduction (bone conduction when available) behavioral testing, and distortion product otoacoustic emissions (DPOAEs) to measure hearing sensitivity and outer hair cell function. We tested 81 individuals with WS aged 5.33-59.50 years. Sixty-three percent of the school-age and 92% of the adult participants had mild to moderately-severe hearing loss. The hearing loss in at least 50% was sensorineural. DPOAE testing corroborated behavioral results. Strikingly, 12 of 14 participants with hearing within normal limits bilaterally had 4,000-Hz DPOAE input/output (DPOAE IO) functions indicative of outer hair cell damage and impaired cochlear compression. Our results indicate that hearing loss is very common in WS. Furthermore, individuals with WS who have "normal" hearing as defined by behavioral thresholds may actually have sub-clinical impairments or undetected cochlear pathology. Our findings suggest outer hair cell dysfunction in otherwise normal hearing individuals. The DPOAE IO in this same group revealed growth functions typically seen in groups with noise-induced damage. Given this pattern of findings, individuals with WS may be at increased risk of noise-induced hearing loss. Recommendations regarding audiological testing for individuals with WS and accommodations for these individuals in both academic and nonacademic settings are provided.

Marler JA; Sitcovsky JL; Mervis CB; Kistler DJ; Wightman FL

2010-05-01

333

Current aspects of hearing loss from occupational and leisure noise  

Directory of Open Access Journals (Sweden)

Full Text Available Hearing loss from occupational and leisure noise numbers amongst the most frequent causes of an acquired sensorineural hearing loss. Here we present a review of up-to-date findings on the pathophysiology of acoustic injury to the inner ear, with special attention being paid to its molecular-biological and genetic aspects. Epidemiological aspects shall also be dealt with, as shall the roles of lacking recovery from occupational noise due to additional exposure by leisure noise and the combined exposure of noise and chemicals. Based on the epidemiological and pathophysiological findings and against the background of published animal-experimental, pre-clinical and clinical findings, the various approaches for prevention, protection and therapeutic intervention with acoustic trauma are discussed. Pharmacological strategies involving anti-oxidative, anti-excitotoxic and anti-apoptotic substances as well as non-pharmacological strategies like "sound conditioning" are given attention. Furthermore, systemic and local substance application as well as the therapy of acute acoustic trauma and chronic hearing problems (including modern therapy forms for comorbidities such as tinnitus) shall be delved into.

Plontke, S.; Zenner, H.-P.

2004-01-01

334

Dual sensory loss: A major age-related increase of comorbid hearing loss and hearing aid ownership in visually impaired adults.  

UK PubMed Central (United Kingdom)

CONCLUSIONS: The high prevalence of dual sensory loss calls for more awareness of related problems in these patients. Differences between the Netherlands and Belgium regarding hearing aid ownership might be due to different criteria used for hearing aid referral and insurance policies. For patients with dual sensory loss, specialized care implemented in low vision rehabilitation seems warranted. Geriatr Gerontol Int 2013; ??: ??-??.

Vreeken HL; van Rens GH; Knol DL; van Reijen NA; Kramer SE; Festen JM; van Nispen RM

2013-08-01

335

Talker differences in clear and conversational speech: vowel intelligibility for older adults with hearing loss.  

UK PubMed Central (United Kingdom)

PURPOSE: To establish the range of talker variability for vowel intelligibility in clear versus conversational speech for older adults with hearing loss and to determine whether talkers who produced a clear speech benefit for young listeners with normal hearing also did so for older adults with hearing loss. METHOD: Clear and conversational vowels in /bVd/ context produced by 41 talkers were presented in noise for identification by 40 older (ages 65-87 years) adults with sloping sensorineural hearing loss. RESULTS: Vowel intelligibility within each speaking style and the size of the clear speech benefit varied widely among talkers. The clear speech benefit was equivalent to that enjoyed by young listeners with normal hearing in an earlier study. Most talkers who had produced a clear speech benefit for young listeners with normal hearing also did so for the older listeners with hearing loss in the present study. However, effects of talker gender differed between listeners with normal hearing and listeners with hearing loss. CONCLUSION: The clear speech vowel intelligibility benefit generated for listeners with hearing loss varied considerably among talkers. Most talkers who produced a clear speech benefit for normal-hearing listeners also produced a benefit for listeners with hearing loss.

Ferguson SH

2012-06-01

336

Comparison of audiometric screening criteria for the identification of noise-induced hearing loss in adolescents.  

UK PubMed Central (United Kingdom)

PURPOSE: To ascertain whether current pure-tone school hearing screening criteria used across the United States are adequate for the early identification of noise-induced hearing loss (NIHL) in adolescents. METHOD: School-based pure-tone hearing screening protocols were collected, reviewed, and consolidated from 46 state agencies. A retrospective categorical analysis of air-conduction audiometric thresholds from a computerized database of 9th-grade (n = 376) and 12th-grade (n = 265) students from a suburban high school was conducted. The database analysis was designed to determine whether each screening protocol would identify high-frequency notched audiometric configurations suggestive of NIHL when using the noise notch criteria described by A. S. Niskar et al. (2001). RESULTS: All of the school-based hearing screening criteria identified significantly (p hearing screening protocols used in the United States will identify only 22% of the students with an HFN and consequently would fail to detect a potential NIHL. CONCLUSIONS: Currently implemented school-based hearing screening guidelines are nonstandardized and inadequate for the early identification of NIHL. This denies the majority of students the opportunity to receive early intervention and to prevent further progression of NIHL. It is necessary to identify, standardize, and implement effective and efficient screening or monitoring programs for the early detection and prevention of NIHL in adolescents.

Meinke DK; Dice N

2007-12-01

337

Mesenchymal stem cell transplantation to the mouse cochlea as a treatment for childhood sensorineural hearing loss.  

UK PubMed Central (United Kingdom)

OBJECTIVE: There is no treatment established for congenital sensorineural hearing loss because the majority of the cases are hereditary. Although congenital sensorineural hearing loss is thought to be hereditary, this hearing loss occur postnatally. We hypothesized that the transplantation of MSCs (mesenchymal stem cells) to the cochlea would be an effective therapy for stopping or delaying the progression of sensorineural hearing loss in childhood. METHODS: Cultured mouse MSCs were labeled with EGFP (enhanced green fluorescence protein) using retroviruses. EGFP-MSCs were transplanted into the posterior semicircular canal of mice at 2-3 weeks (young group) and 24-26 weeks (adult group) of age by a novel perilymphatic perfusion technique. Engraftment of MSCs was evaluated immunohistologically at 1 week and 2 weeks after transplantation. RESULTS: In young mice, migrated MSCs were detected in the cochlea tissue by immunofluorescence for EGFP and by immunohistochemistry for fibronectin. The differentiation of migrated MSCs into fibrocyte-like cells was demonstrated by immunofluorescence for connexin 26. There were no adverse effects on auditory function by MSC transplantation, and the auditory brain stem responses threshold did not significantly shift after surgery. In contrast, neither MSC migration nor differentiation was detected in the adult mice canal after MSC transplantation. CONCLUSION: The bone marrow derived MSCs were successfully transplanted into the cochlea of young mice by the perilymphatic perfusion technique and were further differentiated into fibrocyte-like cells without any adverse effects on auditory function.

Kasagi H; Kuhara T; Okada H; Sueyoshi N; Kurihara H

2013-06-01

338

Effects of cigarette smoking on the evolution of hearing loss caused by industrial noise  

Directory of Open Access Journals (Sweden)

Full Text Available The few studies evaluating the changes caused by cigarette smoking on hearing loss induced by occupational exposure to noise have reached discordant conclusions. The aim of this study is to investigate the interactions between cigarette smoking and occupational exposure to noise as risk factors in the onset and development of hearing loss. The study was performed on a sample of 557 shipyard workers exposed to noise at an Equivalent Level (Leq) of 93 dBA. On the basis of their smoking habits, they were divided into three groups: group (A), non-smokers; group (B), smokers (15-30 cigarettes per day); and group (C), heavy smokers (over 30 cigarettes per day). The study focussed on the audiometric responses of the subjects at the frequencies of 500, 1000, 2000, 3000 and 4000 Hz. The results were then compared using statistical techniquees (Internal correlation coefficient, exponential model, ANCOVA, NPC test). Comparison of the audiometric responses showed statistically significant differences between the three groups. Non-parametric analysis, performed using the NPC test, highlighted that the interaction between smoking and exposure to noise has an influence on hearing loss at all frequencies, and particularly at high frequencies (3000-4000 Hz). The data obtained from the examined sample show that smoking and exposure to noise cause an increase in occupational hearing loss and that this is directly related to the number of cigarettes smoked.

Abbate Carmelo; Giorgianni Concetto; Zirilli Agata; Tringali Maria Antonietta; D’Arrigo Graziella; Brecciaroli Renato; Abbate Adriana; Salmaso Luigi

2010-01-01

339

Contrast-enhanced MR imaging of the endolymphatic sac in patients with sudden hearing loss  

International Nuclear Information System (INIS)

Our objective was to evaluate the frequency of contrast enhancement of the endolymphatic sac in patients with sudden hearing loss. Forty consecutive patients with sudden sensorineural hearing loss (20 males and 20 females; age range 11-82 years), 40 age-matched control subjects, and 5 patients with Meniere's disease were examined using the same imaging protocol on a 1.5-T MR system. Pre- and post-contrast-enhanced T1-weighted 3D spoiled gradient-echo sequence (3D SPGR; TR/TE=23/10 ms, no. of excitations=1, flip angle=30 ) images were obtained using a voxel size of 0.6 x 0.7 x 0.8 mm3. Contrast enhancement in the area of the endolymphatic sac was assessed by two radiologists, and the frequency of contrast enhancement was compared between the three study groups. Enhancement of the ipsilateral endolymphatic sac was observed in 30 of the 40 patients with sudden hearing loss (75%). Twenty of these 30 patients also showed enhancement on the contralateral side, and 1 patient showed enhancement only on the contralateral side. Only 1 of the 5 patients with Meniere's disease showed enhancement. Nine of the 40 control subjects (22.5%) showed enhancement (bilateral enhancement in 5 subjects, unilateral in 4). The frequency of enhancement in patients with sudden hearing loss was significantly higher than that in control subjects (P

2002-01-01

340

Prognosis and treatment of sudden sensorineural hearing loss.  

UK PubMed Central (United Kingdom)

Most cases of sudden sensorineural hearing loss (SHL) are idiopathic. Consequently, the otologist may be asked to predict hearing recovery and select a treatment strategy without fully understanding the disease process. We retrospectively reviewed the charts of 837 patients with SHL to evaluate the prognostic value of specific clinical parameters and the effectiveness of steroid and vasodilator treatments. Treatment response was defined by the patient's subjective response and audiological criteria. Patients who were treated with steroids and/or vasodilators were more likely to improve. Patients who improved had a worse initial pure-tone average (PTA) than those who did not improve. In addition, those with poorer initial speech discrimination scores, worse initial thresholds at 4,000 Hz, younger age, and greater number of treatments were more likely to improve. Neither the electronystagmogram results nor the initial audiogram shape were valuable indicators. Recognition of prognostic indicators can help in counselling patients and in the evaluation of treatment response.

Fetterman BL; Saunders JE; Luxford WM

1996-07-01

 
 
 
 
341

GJB2-associated hearing loss undetected by hearing screening of newborns.  

UK PubMed Central (United Kingdom)

The hearing loss caused by GJB2 mutations is usually congenital in onset, moderate to profound in degree, and non-progressive. The objective of this study was to study genotype/phenotype correlations and to document 14 children with biallelic GJB2 mutations who passed newborn hearing screening (NHS). Genetic testing for GJB2 mutations by direct sequencing was performed on 924 individuals (810 families) with hearing loss, and 204 patients (175 families) were found to carry biallelic GJB2 mutations. NHS results were obtained through medical records. A total of 18 pathological mutations were identified, which were subclassified as eight inactivating and 10 non-inactivating mutations. p.I128M and p.H73Y were identified as novel missense GJB2 mutations. Of the 14 children with biallelic GJB2 mutations who passed NHS, eight were compound heterozygotes and 3 were homozygous for the c.235delC mutation in GJB2, and the other three combinations of non-c.235delC mutations identified were p.Y136X-p.G45E/p.V37I heterozygous, c.512ins4/p.R143W heterozygous, and p.V37I/p.R143W heterozygous. These 14 cases demonstrate that the current NHS does not identify all infants with biallelic GJB2 mutations. They suggest that the frequency of non-penetrance at birth is approximately 6.9% or higher in DFNB1 patients and provide further evidence that GJB2 hearing loss may not always be congenital in onset.

Minami SB; Mutai H; Nakano A; Arimoto Y; Taiji H; Morimoto N; Sakata H; Adachi N; Masuda S; Sakamoto H; Yoshida H; Tanaka F; Sugiuchi T; Kaga K; Matsunaga T

2013-09-01

342

GJB2-associated hearing loss undetected by hearing screening of newborns.  

Science.gov (United States)

The hearing loss caused by GJB2 mutations is usually congenital in onset, moderate to profound in degree, and non-progressive. The objective of this study was to study genotype/phenotype correlations and to document 14 children with biallelic GJB2 mutations who passed newborn hearing screening (NHS). Genetic testing for GJB2 mutations by direct sequencing was performed on 924 individuals (810 families) with hearing loss, and 204 patients (175 families) were found to carry biallelic GJB2 mutations. NHS results were obtained through medical records. A total of 18 pathological mutations were identified, which were subclassified as eight inactivating and 10 non-inactivating mutations. p.I128M and p.H73Y were identified as novel missense GJB2 mutations. Of the 14 children with biallelic GJB2 mutations who passed NHS, eight were compound heterozygotes and 3 were homozygous for the c.235delC mutation in GJB2, and the other three combinations of non-c.235delC mutations identified were p.Y136X-p.G45E/p.V37I heterozygous, c.512ins4/p.R143W heterozygous, and p.V37I/p.R143W heterozygous. These 14 cases demonstrate that the current NHS does not identify all infants with biallelic GJB2 mutations. They suggest that the frequency of non-penetrance at birth is approximately 6.9% or higher in DFNB1 patients and provide further evidence that GJB2 hearing loss may not always be congenital in onset. PMID:24013081

Minami, Shujiro B; Mutai, Hideki; Nakano, Atsuko; Arimoto, Yukiko; Taiji, Hidenobu; Morimoto, Noriko; Sakata, Hideaki; Adachi, Nodoka; Masuda, Sawako; Sakamoto, Hirokazu; Yoshida, Haruo; Tanaka, Fujinobu; Morita, Noriko; Sugiuchi, Tomoko; Kaga, Kimitaka; Matsunaga, Tatsuo

2013-09-06

343

The Effect of Stimulus Bandwidth on Perception of Fricative /s/ among Individuals with Different Degrees of Sensorineural Hearing Loss  

Directory of Open Access Journals (Sweden)

Full Text Available Most of the speech sounds that contribute to speech intelligibility are dominated by high-frequency components. The phoneme /s/ is the third or fourth most frequently occurring phoneme in the English language and second most frequently occurring consonantal phoneme in Hindi language. Given the importance of the phoneme /s/, it is ironic that, this sound contains the highest frequency acoustic elements of any speech sound in English and most of the non-English languages ranging from 4500 Hz to more than 8000 Hz. The most common type of hearing impairment affecting speech perception is high-frequency sensorineural loss (SN) and such individuals require good high frequency audibility in order to better perceive fricative cues, regardless of hearing status. While many studies appear to support the general notion that high-frequency amplification may not always be beneficial, the inter-subject variability in most studies precludes a clearly defined rule that would distinguish listeners who are likely to benefit from high-frequency amplification from those who are not. The current study is aimed to determine and compare the effective bandwidth required for the perception of fricative /s/ in individuals with normal hearing and hearing impairment as a function of degree of hearing loss. A total of 100 Hindi speaking subjects equally divided into four groups (Group I: Normal hearing, Group II: Moderate SN hearing loss, Group III: Moderately severe SN hearing loss, Group IV: Severe SN hearing loss) participated in the study. Nonsense syllables containing the phonemes /s/, /f/, /?/ and /c/ in /i/ vowel context and low pass filtered at 1, 2, 3, 4, 5, 6, 7, 8 and 9 KHz produced by a female talker were used as stimulus. The results revealed that there was a statistically significant effect (p<0.05) of bandwidth for the perception /s/ between different groups at 1 KHz, 2 KHz, 3 KHz, 4 KHz, 5 KHz, 6 KHz, 7 KHz and 8 KHz and no significant effect (p>0.05) was seen at 9 KHz between groups. In addition, individuals with normal hearing required lower bandwidth for accurate fricative perception and there was a statistically significant difference (p<0.05) in mean bandwidth between groups. Among the hearing impaired group, as the degree of hearing loss increased the subjects required higher bandwidth for accurate perception of fricative. This study has important implications in knowing the effective bandwidth required for the perception of high frequency speech sounds among individuals with hearing loss on individual basis which in turn helps in the selection of appropriate rehabilitative devices.

Neha Yadav; S. B. Rathna Kumar; S. B. Annapurna; V. Josephine Vinila

2011-01-01

344

Classifying human audiometric phenotypes of age-related hearing loss from animal models.  

Science.gov (United States)

Age-related hearing loss (presbyacusis) has a complex etiology. Results from animal models detailing the effects of specific cochlear injuries on audiometric profiles may be used to understand the mechanisms underlying hearing loss in older humans and predict cochlear pathologies associated with certain audiometric configurations ("audiometric phenotypes"). Patterns of hearing loss associated with cochlear pathology in animal models were used to define schematic boundaries of human audiograms. Pathologies included evidence for metabolic, sensory, and a mixed metabolic + sensory phenotype; an older normal phenotype without threshold elevation was also defined. Audiograms from a large sample of older adults were then searched by a human expert for "exemplars" (best examples) of these phenotypes, without knowledge of the human subject demographic information. Mean thresholds and slopes of higher frequency thresholds of the audiograms assigned to the four phenotypes were consistent with the predefined schematic boundaries and differed significantly from each other. Significant differences in age, gender, and noise exposure history provided external validity for the four phenotypes. Three supervised machine learning classifiers were then used to assess reliability of the exemplar training set to estimate the probability that newly obtained audiograms exhibited one of the four phenotypes. These procedures classified the exemplars with a high degree of accuracy; classifications of the remaining cases were consistent with the exemplars with respect to average thresholds and demographic information. These results suggest that animal models of age-related hearing loss can be used to predict human cochlear pathology by classifying audiograms into phenotypic classifications that reflect probable etiologies for hearing loss in older humans. PMID:23740184

Dubno, Judy R; Eckert, Mark A; Lee, Fu-Shing; Matthews, Lois J; Schmiedt, Richard A

2013-06-06

345

Can Uhear me now? Validation of an iPod-based hearing loss screening test.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate the uHear iPod-based application as a test for hearing loss. METHODS: We recruited 100 adult participants through a single otology practice. Patients with otorrhea and cognitive impairment were excluded. All patients completed the uHear test in the clinic and in the sound booth and underwent a standard audiogram by the same audiologist. We compared the results of the uHear test to the standard audiogram. RESULTS: The uHear was able to correctly diagnose the presence of hearing loss (pure-tone average [PTA] > 40 dB) with a sensitivity of 98% (95% CI = 89-100), a specificity of 82% (95% CI = 75-88), and a positive likelihood ratio of 9 (95% CI = 6.0-16). Compared to the audiogram, the uHear overestimated the PTA among all ears by 14 dB in the clinic and by 8 dB in the sound booth (p < .0001). Compared to the audiogram, the uHear overestimated the PTA among ears with hearing loss by 6 dB in the clinic and by 4 dB in the sound booth. CONCLUSIONS: The uHear application is a reasonable screening test to rule out moderate hearing loss (PTA > 40 dB) and and is valid at quantifying the degree of hearing loss in patients known to have abnormal hearing.

Szudek J; Ostevik A; Dziegielewski P; Robinson-Anagor J; Gomaa N; Hodgetts B; Ho A

2012-04-01

346

Evaluation of unilateral sensorineural hearing loss in the pediatric patient.  

UK PubMed Central (United Kingdom)

OBJECTIVES: This study is a review of our series of pediatric patients with unilateral sensorineural hearing loss (USNHL) to report abnormalities on imaging studies, review genetic and ophthalmologic results, and survey audiometric findings. METHODS: This study is a retrospective chart review of all pediatric patients with USNHL seen between 1/1/03 and 12/31/08 at our institution. The study was approved by the institutional review board. RESULTS: Eighty-nine cases were identified with audiometric findings confirming unilateral hearing thresholds greater than 20 dBHL with no conductive component. There were 48 males and 41 females. Average age of diagnosis was 7 years. One audiogram showed low-frequency loss, 17 mid-frequency, 29 high-frequency, and 32 flat. Ten patients were diagnosed by auditory brainstem response testing at another institution, with thresholds not available for review. Eleven percent of patients progressed to bilateral loss. Sixty-one patients underwent computed tomography of temporal bones (CTTB). Twenty of 61 scans identified 34 anomalies including 15 enlarged vestibular aqueducts (EVAs), 8 Mondini, and 3 superior semicircular canal dehiscences (SSCDs). Thirty-one of 89 patients underwent magnetic resonance imaging (MRI). Three of these 31 patients had positive findings including 1 EVA, 1 Mondini, and 1 asymmetric internal auditory canal. When CTTB was positive, no additional lesions were detected on MRI. When CTTB was negative and MRI was done in 20 patients, 2 additional lesions were detected by MRI. Fourteen patients had genetics evaluation of which 6 had positive findings, including CHARGE, VACTERL, Goldenhar, and 3 were heterozygous for a Connexin mutation. CONCLUSIONS: CTTB is an effective diagnostic tool for USNHL. MRI should be considered in patients with negative CTTB. Genetics and ophthalmologic evaluations are recommended for patients with risk factors or an abnormal clinical examination. Close follow-up is essential due to high rate of hearing loss progression.

Haffey T; Fowler N; Anne S

2013-06-01

347

Quantification of autonomic regulation in patients with sudden sensorineural hearing loss.  

Science.gov (United States)

Previous studies have proposed varying causes for idiopathic sudden sensorineural hearing loss (SSNHL), including vascular occlusion, ruptured inner ear membrane, acoustic tumours and circulatory disturbances in the inner ear. The objective of this study was to characterise the autonomic regulation in 19 SSNHL patients in comparison to 19 healthy age-gender matched normal-hearing control subjects (CON) in order to improve the diagnostics of vascular caused hearing loss in SSNHL patients. A high-resolution short-term electrocardiogram (ECG) and the continuous noninvasive blood pressure signal were simultaneously recorded under resting conditions (30min). Linear and nonlinear indices of heart rate- and blood pressure variability (HRV, BPV) were calculated to characterise autonomic regulation. The results showed that HRV analysis did not produce significantly different results between SSNHL and CON, whereas linear and nonlinear BPV indices showed significant differences between both groups (p<0.01). This study was the first to show an altered cardiovascular regulation in SSNHL patients when compared to CON subjects, based on continuous blood pressure analysis. This was characterised by reduced variability, complexity and dynamics of blood pressure time series in SSNHL. These findings may contribute to an improved classification of the controversially discussed causes of SSNHL and, in addition, may lead to improved diagnostic strategies for a subgroup of SSNHL patients whose hearing loss is caused by cardiovascular factors. PMID:23491325

Schulz, Steffen; Ritter, Julia; Oertel, Katrin; Witt, Katharina; Bär, Karl-Jürgen; Guntinas-Lichius, Orlando; Voss, Andreas

2013-03-13

348

Predictors of hearing loss in school entrants in a developing country  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Hearing loss is a prevalent and significant disability that impairs functional development and educational attainment of school children in developing countries. Lack of a simple and practical screening protocol often deters routine and systematic hearing screening at school entry. Aim: To identify predictors of hearing loss for a practical screening model in school-aged children. Settings and Design: Community-based, retrospective case-control study of school entrants in an inner city. Methods: Results from the audiologic and non-audiologic examination of 50 hearing impaired children in randomly selected mainstream schools were compared with those of a control group of 150 normal hearing children, matched for age and sex from the same population. The non-audiologic evaluation consisted of medical history, general physical examination, anthropometry, motor skills, intelligence and visual acuity while the audiologic assessment consisted of otoscopy, audiometry and tympanometry. Statistical Analysis: Multiple logistic regression analysis of significant variables derived from univariate analysis incorporating student t-test and chi-square. Results: Besides parental literacy (OR:0.3; 95% CI:0.16-0.68), non-audiologic variables showed no association with hearing loss. In contrast, most audiologic indicators, enlarged nasal turbinate (OR:3.3; 95% CI:0.98-11.31), debris or foreign bodies in the ear canal (OR:5.4; 95% CI:1.0-36.03), impacted cerumen (OR:6.2; 95% CI:2.12-14.33), dull tympanic membrane (OR:2.2; 95% CI:1.10-4.46), perforated ear drum (OR:24.3; 95% CI:2.93-1100.17) and otitis media with effusion OME (OR:14.2; 95% CI:6.22-33.09), were associated with hearing loss. However, only parental literacy (OR:0.3; 95% CI:0.16-0.69), impacted cerumen (OR:4.0; 95% CI:1.66-9.43) and OME (OR:11.0; 95% CI:4.74-25.62) emerged as predictors. Conclusion: Selective screening based on the identification of impacted cerumen and OME will facilitate the detection of a significant proportion of hearing impaired school entrants.

Olusanya Bola; Okolo A; Adeosun A

2004-01-01

349

The Need for Improved Detection and Management of Adult-Onset Hearing Loss in Australia  

Science.gov (United States)

Adult-onset hearing loss is insidious and typically diagnosed and managed several years after onset. Often, this is after the loss having led to multiple negative consequences including effects on employment, depressive symptoms, and increased risk of mortality. In contrast, the use of hearing aids is associated with reduced depression, longer life expectancy, and retention in the workplace. Despite this, several studies indicate high levels of unmet need for hearing health services in older adults and poor use of prescribed hearing aids, often leading to their abandonment. In Australia, the largest component of financial cost of hearing loss (excluding the loss of well-being) is due to lost workplace productivity. Nonetheless, the Australian public health system does not have an effective and sustainable hearing screening strategy to tackle the problem of poor detection of adult-onset hearing loss. Given the increasing prevalence and disease burden of hearing impairment in adults, two key areas are not adequately met in the Australian healthcare system: (1) early identification of persons with chronic hearing impairment; (2) appropriate and targeted referral of these patients to hearing health service providers. This paper reviews the current literature, including population-based data from the Blue Mountains Hearing Study, and suggests different models for early detection of adult-onset hearing loss.

McMahon, Catherine M.; Gopinath, Bamini; Schneider, Julie; Reath, Jennifer; Hickson, Louise; Leeder, Stephen R.; Mitchell, Paul; Cowan, Robert

2013-01-01

350

The need for improved detection and management of adult-onset hearing loss in australia.  

UK PubMed Central (United Kingdom)

Adult-onset hearing loss is insidious and typically diagnosed and managed several years after onset. Often, this is after the loss having led to multiple negative consequences including effects on employment, depressive symptoms, and increased risk of mortality. In contrast, the use of hearing aids is associated with reduced depression, longer life expectancy, and retention in the workplace. Despite this, several studies indicate high levels of unmet need for hearing health services in older adults and poor use of prescribed hearing aids, often leading to their abandonment. In Australia, the largest component of financial cost of hearing loss (excluding the loss of well-being) is due to lost workplace productivity. Nonetheless, the Australian public health system does not have an effective and sustainable hearing screening strategy to tackle the problem of poor detection of adult-onset hearing loss. Given the increasing prevalence and disease burden of hearing impairment in adults, two key areas are not adequately met in the Australian healthcare system: (1) early identification of persons with chronic hearing impairment; (2) appropriate and targeted referral of these patients to hearing health service providers. This paper reviews the current literature, including population-based data from the Blue Mountains Hearing Study, and suggests different models for early detection of adult-onset hearing loss.

McMahon CM; Gopinath B; Schneider J; Reath J; Hickson L; Leeder SR; Mitchell P; Cowan R

2013-01-01

351

Long-term Assessment of Systemic Inflammation and the Cumulative Incidence of Age-related Hearing Impairment in the Epidemiology of Hearing Loss Study.  

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BACKGROUND: Although research has linked systemic inflammation to various diseases of aging, few studies have examined the potential role it may play in the development of age-related hearing impairment. METHODS: Among 1,073 participants free of hearing impairment (pure-tone average 0.5, 1, 2, 4kHz ? 25 dB HL) in the population-based Epidemiology of Hearing Loss Study (1998-2000), serum C-reactive protein, and interleukin-6 were measured at three time points (1988-1990, 1998-2000, and 2009-2010), and tumor necrosis factor-? was measured at one time point (1998-2000), whereas hearing impairment was measured again in 2003-2005 and 2009-2010 to determine the 10-year cumulative incidence. RESULTS: Inflammatory marker levels from a single time point (1998-2000) were not associated with an increased risk of developing hearing impairment. Associations between long-term serum C-reactive protein levels and incident hearing impairment differed by age (p = .031). Participants less than 60 years with consistently high (>3 mg/L) or increasing levels of serum C-reactive protein over 10 years were nearly two times (hazard ratio: 1.96, 95% confidence interval: 1.19, 3.23) as likely to develop hearing impairment over the subsequent 10-year period, an association not seen in participants more than or equal to 60 years. A statistically significant association (p-trend = .041) was also observed between number of markers in the highest group at baseline and incident hearing impairment in this younger age group. CONCLUSIONS: Associations between long-term serum C-reactive protein levels and incident hearing impairment were observed in the cohort as a whole, but differed significantly by age group, with statistically significant associations observed in adults less than 60 years, participants moving through the peak risk period for hearing impairment over the course of the study. PMID:23739996

Nash, Scott D; Cruickshanks, Karen J; Zhan, Weihai; Tsai, Michael Y; Klein, Ronald; Chappell, Rick; Nieto, F Javier; Klein, Barbara E K; Schubert, Carla R; Dalton, Dayna S; Tweed, Theodore S

2013-06-01

352

Connexin 26 Gene Mutations in Non-Syndromic Hearing Loss Among Kuwaiti Patients.  

UK PubMed Central (United Kingdom)

Objective: To study connexin 26 (Cx26) gene mutations among autosomal recessive non-syndromal hearing loss in Kuwaiti patients and evaluate their effect on phenotypes. Subjects and Methods: This cross sectional study included 100 patients aged between 6 months and 18 years, who were referred to the Sheikh Salem Al-Ali Centre for audiology and speech evaluation of autosomal recessive non-syndromic sensorineural hearing loss confirmed by clinico-genetic evaluation and a battery of diagnostic tests. Gene profiling and sequencing were performed to detect the presence and nature of Cx26 mutation. Results: Of the 100 patients, mutation of Cx26 gene was detected in 15 patients (15%) of which 9 (60%) cases were heterozygous and 6 cases (40%) were homozygous. Eighty per cent of the 15 Cx26 positive cases resulted from the 35delG mutation. Among the heterozygous cases, 6 (66.6%) were positive for 35delG. All 6 homozygous patients were positive for the 35delG mutation. A significant correlation was found between genetic findings (p = 0.013) and family history (p = 0.029), as well as the onset (p = 0.015), course (p = 0.033), degree and configuration of hearing loss (p = 0.001). Conclusion: Among the selected Kuwaiti population sample, the Cx26 gene mutation was responsible for 15% of autosomal recessive non-syndromic sensorineural hearing loss. We recommend that screening for Cx26 gene mutation be considered in the screening strategy of patients with non-syndromic childhood hearing loss for counselling and management purposes. © 2013 S. Karger AG, Basel.

Al-Sebeih K; Al-Kandari M; Al-Awadi SA; Hegazy FF; Al-Khamees GA; Naguib KK; Al-Dabbous RM

2013-09-01

353

Congenital cytomegalovirus is the second most frequent cause of bilateral hearing loss in young French children.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To estimate the prevalence of congenital cytomegalovirus (cCMV) among causes of bilateral hearing loss in young French children. STUDY DESIGN: Children <3 years old with hearing loss were prospectively included at their first visit to a referral center. Cytomegalovirus polymerase chain reaction was performed on dried blood spots from Guthrie cards. Medical records were reviewed. RESULTS: One hundred children with bilateral hearing loss were included at a median age of 15 months; the prevalence of cCMV was 8% (8/100) (95% CI, 2.7%-13.3%) in this population and 15.4% (8/52) in the subpopulation of children with profound bilateral hearing loss. Delayed neurodevelopment and brain abnormalities on computed tomography scan were found more often in children with cCMV than in children with hearing loss without cCMV (P = .027, P = .005). In 6 of 8 cCMV cases, cCMV infection had not been diagnosed before the study. CONCLUSIONS: In a comprehensive study of the causes of bilateral hearing loss in young French children, cCMV is the second most frequent cause of hearing loss after connexin mutations. It underlines that a majority of French children with hearing loss and cCMV are not diagnosed early and therefore may not benefit from early intervention including the possibility of neonatal antiviral treatment. These results make the case for promoting systematic cytomegalovirus screening in neonates with confirmed hearing loss identified through neonatal hearing screening.

Avettand-Fenoël V; Marlin S; Vauloup-Fellous C; Loundon N; François M; Couloigner V; Rouillon I; Drouin-Garraud V; Laccourreye L; Denoyelle F; Guilleminot T; Grabar S; Leruez-Ville M

2013-03-01

354

Can Noise in Dental Clinic Produce Hearing Loss?  

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Full Text Available Introduction: The sensorial hearing loss and irreversible noise induced is the major evitable occupational cause of hearing loss worldwide. The dentists are health professionals exposed to noises from equipment in their clinics and may suffer hearing losses. Objective: Measure the noise intensities emitted by the high rotation motors (mar) used in public and private dental clinics, check whether they are harmful for the human ear and compare the results obtained in such services. Method: Serial, retrospective study with measures of the noise intensities in dBNA with a decibelimeter Minipa MSL-1352C, USA, in four dental clinics of the public service and four private clinics in Jundiaí-SP, initially from the basal environment noise in each clinic, during five minutes and then from the noise emitted by the high rotation motor (mar) in operation during five minutes to obtain the averages. Results:Public clinics: 1)basal medium=56.4dB;mar=77.2dB. 2)basal medium=61.7dB;mar=73.7dB. 3)basal medium=61.07dB;mar=75.04dB. 4)basal medium=63.6dB;mar=77.3dB. Private clinics: 1)basal medium=60,7dB;mar=79,1dB. 2)basal=60,7dB;mar=83,1dB. 3)basal=58,4dB;mar=75,5dB. 4)basal=63dB;mar=76dB. Conclusion: The intensities measured of noise emitted by high rotation motors used in public and private dental clinics are below the limits harmful to the auditory health. In the public service, the basal medium noise intensity is higher than that of the private clinics, however the one of the high rotation motors is higher in the private clinics.

Lourenço, Edmir Américo; Berto, Janaína Medina da Rocha; Duarte, Sávio Butignolli; Greco, João Paulo Martins

2011-01-01

355

Relations between cochlear histopathology and hearing loss in experimental cochlear implantation.  

Science.gov (United States)

This study reviews the cochlear histology from four hearing preservation cochlear implantation experiments conducted on 73 guinea pigs from our institution, and relates histopathological findings to residual hearing. All guinea pigs had normal hearing prior to surgery and underwent cochlear implantation via a cochleostomy with a silastic-platinum dummy electrode. Pure tone auditory brainstem response (ABR) thresholds from 2 to 32 kHz were recorded prior to surgery, and at one and four weeks postoperatively. The cochleae were then fixed in paraformaldehyde, decalcified, paraffin embedded, and mid-modiolar sections were prepared. The treatment groups were as follows: 1) Systemic dexamethasone, 0.2 mg/kg administered 1 h before implantation, 2) Local dexamethasone, 2% applied topically to the round window for 30 min prior to cochlear implantation, 3) Local n-acetyl cysteine, 200 ?g applied topically to the round window for 30 min prior to implantation, 4) inoculation to keyhole-limpet hemocyanin (KLH) prior to implantation, and 5) untreated controls. There was a significant correlation between the extent of the tissue reaction in the cochlea and the presence of foreign body giant cells (FBGCs), new bone formation and injury to the osseous spiral lamina (OSL). The extent of the tissue response, as a percentage of the area of the scala tympani, limited the best hearing that was observed four weeks after cochlear implantation. Poorer hearing at four weeks correlated with a more extensive tissue response, lower outer hair cell (OHC) counts and OSL injury in the basal turn. Progressive hearing loss was also correlated with the extent of tissue response. Hearing at 2 kHz, which corresponds to the region of the second cochlear turn, did not correspond with loco-regional inner hair cell (IHC), OHC or SGC counts. We conclude that cochlear injury is associated with poorer hearing early after implantation. The tissue response is related to indices of cochlear inflammation and injury. An extensive tissue response limits hearing at four weeks, and correlates with progressive hearing loss. These latter effects may be due to inflammation, but would also be consistent with interference of cochlear mechanics. PMID:23396095

O'Leary, S J; Monksfield, P; Kel, G; Connolly, T; Souter, M A; Chang, A; Marovic, P; O'Leary, J S; Richardson, R; Eastwood, H

2013-02-05

356

Relations between cochlear histopathology and hearing loss in experimental cochlear implantation.  

UK PubMed Central (United Kingdom)

This study reviews the cochlear histology from four hearing preservation cochlear implantation experiments conducted on 73 guinea pigs from our institution, and relates histopathological findings to residual hearing. All guinea pigs had normal hearing prior to surgery and underwent cochlear implantation via a cochleostomy with a silastic-platinum dummy electrode. Pure tone auditory brainstem response (ABR) thresholds from 2 to 32 kHz were recorded prior to surgery, and at one and four weeks postoperatively. The cochleae were then fixed in paraformaldehyde, decalcified, paraffin embedded, and mid-modiolar sections were prepared. The treatment groups were as follows: 1) Systemic dexamethasone, 0.2 mg/kg administered 1 h before implantation, 2) Local dexamethasone, 2% applied topically to the round window for 30 min prior to cochlear implantation, 3) Local n-acetyl cysteine, 200 ?g applied topically to the round window for 30 min prior to implantation, 4) inoculation to keyhole-limpet hemocyanin (KLH) prior to implantation, and 5) untreated controls. There was a significant correlation between the extent of the tissue reaction in the cochlea and the presence of foreign body giant cells (FBGCs), new bone formation and injury to the osseous spiral lamina (OSL). The extent of the tissue response, as a percentage of the area of the scala tympani, limited the best hearing that was observed four weeks after cochlear implantation. Poorer hearing at four weeks correlated with a more extensive tissue response, lower outer hair cell (OHC) counts and OSL injury in the basal turn. Progressive hearing loss was also correlated with the extent of tissue response. Hearing at 2 kHz, which corresponds to the region of the second cochlear turn, did not correspond with loco-regional inner hair cell (IHC), OHC or SGC counts. We conclude that cochlear injury is associated with poorer hearing early after implantation. The tissue response is related to indices of cochlear inflammation and injury. An extensive tissue response limits hearing at four weeks, and correlates with progressive hearing loss. These latter effects may be due to inflammation, but would also be consistent with interference of cochlear mechanics.

O'Leary SJ; Monksfield P; Kel G; Connolly T; Souter MA; Chang A; Marovic P; O'Leary JS; Richardson R; Eastwood H

2013-04-01

357

Interaction of smoking and occupational noise exposure on hearing loss: a cross-sectional study  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Noise is the most common hazardous agent at workplaces. Noise induced hearing loss (NIHL) has been known since the industrial revolution. Although NIHL is permanent, irreversible and frequent, it is preventable. The economic costs of NIHL have been estimated to be about billions of dollars. Besides, cigarette smoking is a common habit worldwide, and according to some recent studies smoking and noise may act in common causal pathways for hearing loss. Methods A cross-sectional study was designed to study the effect of smoking on NIHL in 206 male smoker workers and 206 male non-smoker workers in a large food-producing factory, in which workers were exposed to noise levels exceeding 85dBA. To determine noise exposure level, we used sound level measurements reported by industrial hygienists. A qualified audiologist assessed hearing acuity by using standardized audiometric procedures assuring at least 14 h of noise avoidance. Results We observed that the percentage of workers with hearing threshold differences of greater than or equal to 30 dB between 4000 Hz and 1000 Hz in both ears were 49.5% and 11.2% in smoker and non smoker groups, respectively (Odds ratio = 7.8, 95% CI = 4.7 – 13), and the percentage of workers with a hearing threshold of greater than 25dB at 4000 Hz in the better ear were 63.6% and 18.4% in smoker and non smoker groups, respectively. This difference was statistically significant after adjustment for age and exposure duration. Conclusion It can be concluded that smoking can accelerate noise induced hearing loss, but more research is needed to understand the underlying mechanisms. Accurate follow up of smoker workers who are exposed to noise levels exceeding 85 dBA is suggested. Smokers should periodically attend educational courses on "smoking cessation", especially in noisy workplaces.

Pouryaghoub Gholamreza; Mehrdad Ramin; Mohammadi Saber

2007-01-01

358