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Sample records for seismogram 1-d generation

  1. Generating Seismograms with Deep Neural Networks

    Science.gov (United States)

    Krischer, L.; Fichtner, A.

    2017-12-01

    The recent surge of successful uses of deep neural networks in computer vision, speech recognition, and natural language processing, mainly enabled by the availability of fast GPUs and extremely large data sets, is starting to see many applications across all natural sciences. In seismology these are largely confined to classification and discrimination tasks. In this contribution we explore the use of deep neural networks for another class of problems: so called generative models.Generative modelling is a branch of statistics concerned with generating new observed data samples, usually by drawing from some underlying probability distribution. Samples with specific attributes can be generated by conditioning on input variables. In this work we condition on seismic source (mechanism and location) and receiver (location) parameters to generate multi-component seismograms.The deep neural networks are trained on synthetic data calculated with Instaseis (http://instaseis.net, van Driel et al. (2015)) and waveforms from the global ShakeMovie project (http://global.shakemovie.princeton.edu, Tromp et al. (2010)). The underlying radially symmetric or smoothly three dimensional Earth structures result in comparatively small waveform differences from similar events or at close receivers and the networks learn to interpolate between training data samples.Of particular importance is the chosen misfit functional. Generative adversarial networks (Goodfellow et al. (2014)) implement a system in which two networks compete: the generator network creates samples and the discriminator network distinguishes these from the true training examples. Both are trained in an adversarial fashion until the discriminator can no longer distinguish between generated and real samples. We show how this can be applied to seismograms and in particular how it compares to networks trained with more conventional misfit metrics. Last but not least we attempt to shed some light on the black-box nature of

  2. Programming for seismogram 1-D generation, considering the attenuation and dispersing effects; Programa para gerar sismograma 1-D, considerando os efeitos da atenuacao e dispersao

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Bruno de O.; Oliveira, Sergio A.M. de [Universidade Estadual do Norte Fluminense (UENF), Macae, RJ (Brazil). Lab. de Engenharia e Exploracao do Petroleo (LENEP)

    2004-07-01

    For a processing and an interpretation of correct seismic data, it is necessary to recognize and to know as the factors act that influence in the propagation of the seismic waves, as the attenuation and the dispersion, constituting in the biggest practical impediment for the use of seismic for targets the big depths, limiting the resolution of the method. However these phenomena little are taken in consideration in the analysis of the data, thus the necessity of its bigger agreement, because if attenuation and dispersion they confuse the application of the seismic, if convenient understood and measures, can be valuable sources of information about the constitution of the rocks. Therefore, in this work the effect of the attenuation and dispersion in the data of reflection seismic had been simulated on a program, in Mat-Lab. Being able to generate 1-D seismograms, in the domain of the time, considering the normal incidence of plain wave in a package of plain, horizontal and isotropic layers, taking in account the physical attributes of the way, being able to simulate the effects of ghost and of multiples of free surface, if considering the source in the water. (author)

  3. A hybrid method for the computation of quasi-3D seismograms.

    Science.gov (United States)

    Masson, Yder; Romanowicz, Barbara

    2013-04-01

    The development of powerful computer clusters and efficient numerical computation methods, such as the Spectral Element Method (SEM) made possible the computation of seismic wave propagation in a heterogeneous 3D earth. However, the cost of theses computations is still problematic for global scale tomography that requires hundreds of such simulations. Part of the ongoing research effort is dedicated to the development of faster modeling methods based on the spectral element method. Capdeville et al. (2002) proposed to couple SEM simulations with normal modes calculation (C-SEM). Nissen-Meyer et al. (2007) used 2D SEM simulations to compute 3D seismograms in a 1D earth model. Thanks to these developments, and for the first time, Lekic et al. (2011) developed a 3D global model of the upper mantle using SEM simulations. At the local and continental scale, adjoint tomography that is using a lot of SEM simulation can be implemented on current computers (Tape, Liu et al. 2009). Due to their smaller size, these models offer higher resolution. They provide us with images of the crust and the upper part of the mantle. In an attempt to teleport such local adjoint tomographic inversions into the deep earth, we are developing a hybrid method where SEM computation are limited to a region of interest within the earth. That region can have an arbitrary shape and size. Outside this region, the seismic wavefield is extrapolated to obtain synthetic data at the Earth's surface. A key feature of the method is the use of a time reversal mirror to inject the wavefield induced by distant seismic source into the region of interest (Robertsson and Chapman 2000). We compute synthetic seismograms as follow: Inside the region of interest, we are using regional spectral element software RegSEM to compute wave propagation in 3D. Outside this region, the wavefield is extrapolated to the surface by convolution with the Green's functions from the mirror to the seismic stations. For now, these

  4. Toward 2D Seismic Wavefield Monitoring: Seismic Gradiometry for Long-Period Seismogram and Short-Period Seismogram Envelope applied to the Hi-net Array

    Science.gov (United States)

    Maeda, T.; Nishida, K.; Takagi, R.; Obara, K.

    2015-12-01

    The high-sensitive seismograph network Japan (Hi-net) operated by National Research Institute for Earth Science and Disaster Prevention (NIED) has about 800 stations with average separation of 20 km. We can observe long-period seismic wave propagation as a 2D wavefield with station separations shorter than wavelength. In contrast, short-period waves are quite incoherent at stations, however, their envelope shapes resemble at neighbor stations. Therefore, we may be able to extract seismic wave energy propagation by seismogram envelope analysis. We attempted to characterize seismic waveform at long-period and its envelope at short-period as 2D wavefield by applying seismic gradiometry. We applied the seismic gradiometry to a synthetic long-period (20-50s) dataset prepared by numerical simulation in realistic 3D medium at the Hi-net station layout. Wave amplitude and its spatial derivatives are estimated by using data at nearby stations. The slowness vector, the radiation pattern and the geometrical spreading are extracted from estimated velocity, displacement and its spatial derivatives. For short-periods at shorter than 1 s, seismogram envelope shows temporal and spatial broadening through scattering by medium heterogeneity. It is expected that envelope shape may be coherent among nearby stations. Based on this idea, we applied the same method to the time-integration of seismogram envelope to estimate its spatial derivatives. Together with seismogram envelope, we succeeded in estimating the slowness vector from the seismogram envelope as well as long-period waveforms by synthetic test, without using phase information. Our preliminarily results show that the seismic gradiometry suits the Hi-net to extract wave propagation characteristics both at long and short periods. This method is appealing that it can estimate waves at homogeneous grid to monitor seismic wave as a wavefield. It is promising to obtain phase velocity variation from direct waves, and to grasp wave

  5. Verification Modal Summation Technique for Synthetic and Observation Seismogram for Pidie Jaya Earthquake M6.5

    Science.gov (United States)

    Irwandi, Irwandi; Fashbir; Daryono

    2018-04-01

    Neo-Deterministic Seismic Hazard Assessment (NDSHA) method is a seismic hazard assessment method that has an advantage on realistic physical simulation of the source, propagation, and geological-geophysical structure. This simulation is capable on generating the synthetics seismograms at the sites that being observed. At the regional NDSHA scale, calculation of the strong ground motion is based on 1D modal summation technique because it is more efficient in computation. In this article, we verify the result of synthetic seismogram calculations with the result of field observations when Pidie Jaya earthquake on 7 December 2016 occurred with the moment magnitude of M6.5. Those data were recorded by broadband seismometers installed by BMKG (Indonesian Agency for Meteorology, Climatology and Geophysics). The result of the synthetic seismogram calculations verifies that some stations well show the suitability with observation while some other stations show the discrepancies with observation results. Based on the results of the observation of some stations, evidently 1D modal summation technique method has been well verified for thin sediment region (near the pre-tertiary basement), but less suitable for thick sediment region. The reason is that the 1D modal summation technique excludes the amplification effect of seismic wave occurring within thick sediment region. So, another approach is needed, e.g., 2D finite difference hybrid method, which is a part of local scale NDSHA method.

  6. Synthetic seismograms - II. Synthesis of amplitude spectra and seismograms of P waves from underground nuclear explosions

    International Nuclear Information System (INIS)

    Banghar, A.R.

    1980-01-01

    As a part of programme of seismic detection of underground nuclear explosions, step by step variations in the amplitude spectra and waveforms of P wave signal, as it propagates from source to receiver region, are investigated. Influences on the amplitude spectra and waveforms of teleseismic p waves due to : (1) variation in the shape of reduced displacement potential, (2) variation of mantle Q values, (3) change in depth, (4) various yields, (5) spalling, and (6) variation of crustal structure at source as well as at receiver are studied. The results show that for a yield of 85 kilotons, the time structure of seismograms is nearly same for four types of reduced displacement potentials considered here. The duration of waveforms is affected both by crustal structure at source as well as due to spalling. In general, effect of receiver crust on seismograms is found to be minor. Synthesized and observed P wave seismograms for Longshot, Milrow and Cannikin underground nuclear explosions are computed at various seismometer array stations of the UKAEA. Computed seismograms compare well with the recorded ones. It is seen that: (1) overburden P wave velocity inferred from seismograms is less as compared to its value obtained from on-site measurements, and (2) the source function, the source crust transfer function, the mantle transfer function and the spalling function are the most important factors that influence shaping of spectra and seismograms. (M.G.B.)

  7. Streaming Seismograms into Earth-Science Classrooms

    Science.gov (United States)

    Ammon, C. J.

    2011-12-01

    Seismograms are the fundamental observations upon which seismology is based; they are central to any course in seismology and important for any discussion of earthquake-related phenomena based on seismic observations. Advances in the collection and distribution of seismic data have made the use of research-quality seismograms in any network capable classroom feasible. The development of large, deep seismogram archives place an unprecedented quantity of high-quality data within reach of the modern classroom environment. I describe and discuss several computer tools and classroom activities that I use in introductory (general education) and advanced undergraduate courses that present near real-time research-quality seismic observations in the classroom. The Earth Motion Monitor Application (EMMA), is a MacOS application that presents a visually clear seismogram display that can be projected in classrooms with internet access. Seismic signals from thousands of station are available from the IRIS data center and the bandwidth can be tailored to the particular type of signal of interest (large event, low frequencies; small event, high frequencies). In introductory classes for non-science students, the near realtime display routinely shows magnitude 4.0-5.0 earthquake-generated signals, demonstrating to students the frequency of earthquake occurrence. Over the next few minutes as the waves travel through and across the planet, their arrival on the seismogram display provides some basic data for a qualitative estimate of the event's general location. When a major or great earthquake occurs, a broad-band display of signals from nearby stations can dramatically and dynamically illuminate the frequent activity associated with the aftershock sequence. Routine use of the display (while continuing the traditional classroom activities) provides students with a significant dose of seismogram study. Students generally find all the signals, including variations in seismic

  8. Large seismic source imaging from old analogue seismograms

    Science.gov (United States)

    Caldeira, Bento; Buforn, Elisa; Borges, José; Bezzeghoud, Mourad

    2017-04-01

    In this work we present a procedure to recover the ground motions by a proper digital structure, from old seismograms in analogue physical support (paper or microfilm) to study the source rupture process, by application of modern finite source inversion tools. Despite the quality that the analog data and the digitizing technologies available may have, recover the ground motions with the accurate metrics from old seismograms, is often an intricate procedure. Frequently the general parameters of the analogue instruments response that allow recover the shape of the ground motions (free periods and damping) are known, but the magnification that allow recover the metric of these motions is dubious. It is in these situations that the procedure applies. The procedure is based on assign of the moment magnitude value to the integral of the apparent Source Time Function (STF), estimated by deconvolution of a synthetic elementary seismogram from the related observed seismogram, corrected with an instrument response affected by improper magnification. Two delicate issues in the process are 1) the calculus of the synthetic elementary seismograms that must consider later phases if applied to large earthquakes (the portions of signal should be 3 or 4 times larger than the rupture time) and 2) the deconvolution to calculate the apparent STF. In present version of the procedure was used the Direct Solution Method to compute the elementary seismograms and the deconvolution was processed in time domain by an iterative algorithm that allow constrains the STF to stay positive and time limited. The method was examined using synthetic data to test the accuracy and robustness. Finally, a set of 17 real old analog seismograms from the Santa Maria (Azores) 1939 earthquake (Mw=7.1) was used in order to recover the waveforms in the required digital structure, from which by inversion allows compute the finite source rupture model (slip distribution). Acknowledgements: This work is co

  9. Researches on Key Algorithms in Analogue Seismogram Records Vectorization

    Directory of Open Access Journals (Sweden)

    Maofa WANG

    2014-09-01

    Full Text Available History paper seismograms are very important information for earthquake monitoring and prediction, and the vectorization of paper seismograms is a very import problem to be resolved. In our study, a new tracing algorithm for simulated seismogram curves based on visual filed feature is presented. We also give out the technological process to vectorizing simulated seismograms, and an analog seismic record vectorization system has been accomplished independently. Using it, we can precisely and speedy vectorize analog seismic records (need professionals to participate interactively.

  10. A Multi­Discipline Approach to Digitizing Historic Seismograms

    Energy Technology Data Exchange (ETDEWEB)

    Bartlett, Andrew [Retriever Technology, Sante Fe, NM (United States)

    2016-04-07

    Retriever Technology has developed and has made available free of charge a seismogram digitization software package called SKATE (Seismogram Kit for Automatic Trace Extraction). We have developed an extensive set of algorithms that process seismogram image files, provide editing tools, and output time series data. The software is available online and free of charge at seismo.redfish.com. To demonstrate the speed and cost effectiveness of the software, we have processed over 30,000 images.

  11. Blind deconvolution of seismograms regularized via minimum support

    International Nuclear Information System (INIS)

    Royer, A A; Bostock, M G; Haber, E

    2012-01-01

    The separation of earthquake source signature and propagation effects (the Earth’s ‘Green’s function’) that encode a seismogram is a challenging problem in seismology. The task of separating these two effects is called blind deconvolution. By considering seismograms of multiple earthquakes from similar locations recorded at a given station and that therefore share the same Green’s function, we may write a linear relation in the time domain u i (t)*s j (t) − u j (t)*s i (t) = 0, where u i (t) is the seismogram for the ith source and s j (t) is the jth unknown source. The symbol * represents the convolution operator. From two or more seismograms, we obtain a homogeneous linear system where the unknowns are the sources. This system is subject to a scaling constraint to deliver a non-trivial solution. Since source durations are not known a priori and must be determined, we augment our system by introducing the source durations as unknowns and we solve the combined system (sources and source durations) using separation of variables. Our solution is derived using direct linear inversion to recover the sources and Newton’s method to recover source durations. This method is tested using two sets of synthetic seismograms created by convolution of (i) random Gaussian source-time functions and (ii) band-limited sources with a simplified Green’s function and signal to noise levels up to 10% with encouraging results. (paper)

  12. An interactive program on digitizing historical seismograms

    Science.gov (United States)

    Xu, Yihe; Xu, Tao

    2014-02-01

    Retrieving information from analog seismograms is of great importance since they are considered as the unique sources that provide quantitative information of historical earthquakes. We present an algorithm for automatic digitization of the seismograms as an inversion problem that forms an interactive program using Matlab® GUI. The program integrates automatic digitization with manual digitization and users can easily switch between the two modalities and carry out different combinations for the optimal results. Several examples about applying the interactive program are given to illustrate the merits of the method.

  13. A New Curve Tracing Algorithm Based on Local Feature in the Vectorization of Paper Seismograms

    Directory of Open Access Journals (Sweden)

    Maofa Wang

    2014-02-01

    Full Text Available History paper seismograms are very important information for earthquake monitoring and prediction. The vectorization of paper seismograms is an import problem to be resolved. Auto tracing of waveform curves is a key technology for the vectorization of paper seismograms. It can transform an original scanning image into digital waveform data. Accurately tracing out all the key points of each curve in seismograms is the foundation for vectorization of paper seismograms. In the paper, we present a new curve tracing algorithm based on local feature, applying to auto extraction of earthquake waveform in paper seismograms.

  14. A New Waveform Mosaic Algorithm in the Vectorization of Paper Seismograms

    Directory of Open Access Journals (Sweden)

    Maofa Wang

    2014-11-01

    Full Text Available History paper seismograms are very important information for earthquake monitoring and prediction, and the vectorization of paper seismograms is a very import problem to be resolved. In this paper, a new waveform mosaic algorithm in the vectorization of paper seismograms is presented. We also give out the technological process to waveform mosaic, and a waveform mosaic system used to vectorize analog seismic record has been accomplished independently. Using it, we can precisely and speedy accomplish waveform mosaic for vectorizing analog seismic records.

  15. S-Wave Velocity Structure beneath Southwest North America from Seismogram Comparisons of the Mexico Earthquake on 22 June 1997

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    Bagus Jaya Santosa

    2008-09-01

    Full Text Available This research investigates earth structure beneath the Southwest North America landmass, especially between Mexico and California. Models based on S wave velocities for this area were obtained by carrying out seismogram fitting in time domain and three Cartesian components simultaneously. The data used is from an event, coded as C052297B that occurred in the state of Guerrero, Mexico and it was fitted to synthetic data computed with the GEMINI program at TS network stations. Earth model IASPEI91 and SPREM were used as input to create the synthetic data. Real and synthetic seismograms were subjected to a low-pass filter with a frequency corner of 20 mHz.Waveform analysis results show very unsystematic and strong deviations in the waveform, arrival times, amount of oscillation and the height of the wave amplitude. Discrepancies are met on S, Love, Rayleigh and ScS waves, where the stations epicentral distances are below 300. Deviation in analysis waveform because of the usage of model 1-D of SPREM and IASPEI91, because the 1-D was a kind of average value an elastic property at one particular depth of global earth. With the method of waveform analysis we can see how sensitive waveform is to structures within the layers of the Earth.To explain the discrepancies, a correction to the earth structure is essential. The corrections account for the thickness of the crust, speed gradient of bh, the coefficient for the bh and bv in the upper mantle for surface wave fitting, a small variation of the S speed structure at a layer under the upper mantle above 771 km for S wave fitting, and a small variation at the base the mantle layers for ScS wave fitting. At some stations, a correction for S speed structure have yielded P wave fitting. Results of this research indicate that the 1-D earth model obtained through seismogram fitting at every hypocenter-observation station pair is unique. The S-wave velocity on the upper mantle has strong negative anomalies. This

  16. GPS-seismograms reveal amplified shaking in California's San Joaquin Delta region

    Science.gov (United States)

    Johanson, I. A.

    2014-12-01

    The March 10, 2014, the Mw6.8 Ferndale earthquake occurred off the coast of Northern California, near the Mendocino Triple Junction. Aftershocks suggest a northeast striking fault plane for the strike-slip earthquake, oriented such that the California coast is roughly perpendicular to the rupture plane. Consequently, large amplitude Love waves were observed at seismic stations and continuous GPS stations throughout Northern California. While GPS is less sensitive then broadband instruments, in Northern California their station density is much higher, potentially providing valuable detail. A total of 269 GPS stations that have high-rate (1 sps) data available were used to generate GPS-seismograms. These include stations from the Bay Area Regional Deformation (BARD) network, the Plate Boundary Observatory (PBO, operated by UNAVCO), and the USGS, Menlo Park. The Track software package was used to generate relative displacements between pairs of stations, determined using Delaunay triangulation. This network-based approach allows for higher precision than absolute positioning, because common noise sources, in particular atmospheric noise, are cancelled out. A simple least-squares network adjustment with a stable centroid constraint is performed to transform the mesh of relative motions into absolute motions at individual GPS stations. This approach to generating GPS-seismograms is validated by the good agreement between time series records at 16 BARD stations that are co-located with broadband seismometers from the Berkeley Digital Seismic Network (BDSN). While the distribution of peak dynamic displacements is dominated in long periods by the radiation pattern, at shorter periods other patterns become visible. In particular, stations in the San Joaquin Delta (SJD) region show higher peak dynamic displacements than those in surrounding areas, as well as longer duration shaking. SJD stations also have higher dynamic displacements on the radial component than surrounding

  17. Class Room Exercises Using JMA-59-Type Seismograms for Earthquake Study at High-School Level

    Science.gov (United States)

    Okamoto, Y.; Furuta, S.; Hirota, N.

    2013-12-01

    The JMA-59-type electromagnetic seismograph was the standard seismograph for routine observations by the Japan Meteorological Agency (JMA) from the 1960's to the 1990's. Some features of those seismograms include 1) displacement wave records (electrically integrated from a velocity output by a moving-coil-type sensor), 2) ink records on paper (analog recording with time marks), 3) continuous drum recording for 12 h, and 4) lengthy operation time over several decades. However, the digital revolution in recording systems during the 1990's made these analog features obsolete, and their abundant and bulky paper-based records were stacked and sometimes disregarded in the library of every observatory. Interestingly, from an educational aspect, the disadvantages of these old-fashioned systems become highly advantageous for educational or outreach purposes. The updated digital instrument is essentially a 'black-box,' not revealing its internal mechanisms and being too fast for observing its signal processes. While the old seismometers and recording systems have been disposed of long since, stacks of analog seismograms continue to languish in observatories' back rooms. In our study, we develop some classroom exercises for studying earthquakes at the mid- to high-school level using these analog seismograms. These exercises include 1) reading the features of seismic records, 2) measuring the S-P time, 3) converting the hypocentral distance from Omori's distance formula, 4) locating the epicenter/hypocenter using the S-P times of surrounding stations, and 5) estimating earthquake magnitude using the Tsuboi's magnitude formula. For this calculation we developed a 'nomogram'--a graphical paper calculator created using a Python-based freeware tool named 'PyNomo.' We tested many seismograms and established the following rules: 1) shallow earthquakes are appropriate for using the Tsuboi's magnitude formula; 2) there is no saturation at peak amplitude; 3) seismograms make it easy to

  18. Websim3d: A Web-based System for Generation, Storage and Dissemination of Earthquake Ground Motion Simulations.

    Science.gov (United States)

    Olsen, K. B.

    2003-12-01

    Synthetic time histories from large-scale 3D ground motion simulations generally constitute large 'data' sets which typically require 100's of Mbytes or Gbytes of storage capacity. For the same reason, getting access to a researchers simulation output, for example for an earthquake engineer to perform site analysis, or a seismologist to perform seismic hazard analysis, can be a tedious procedure. To circumvent this problem we have developed a web-based ``community model'' (websim3D) for the generation, storage, and dissemination of ground motion simulation results. Websim3D allows user-friendly and fast access to view and download such simulation results for an earthquake-prone area. The user selects an earthquake scenario from a map of the region, which brings up a map of the area where simulation data is available. Now, by clicking on an arbitrary site location, synthetic seismograms and/or soil parameters for the site can be displayed at fixed or variable scaling and/or downloaded. Websim3D relies on PHP scripts for the dynamic plots of synthetic seismograms and soil profiles. Although not limited to a specific area, we illustrate the community model for simulation results from the Los Angeles basin, Wellington (New Zealand), and Mexico.

  19. A scenario study of seismically induced landsliding in Seattle using broadband synthetic seismograms

    Science.gov (United States)

    Allstadt, Kate E.; Vidale, John E.; Frankel, Arthur D.

    2013-01-01

    We demonstrate the value of utilizing broadband synthetic seismograms to assess regional seismically induced landslide hazard. Focusing on a case study of an Mw 7.0 Seattle fault earthquake in Seattle, Washington, we computed broadband synthetic seismograms that account for rupture directivity and 3D basin amplification. We then adjusted the computed motions on a fine grid for 1D amplifications based on the site response of typical geologic profiles in Seattle and used these time‐series ground motions to trigger shallow landsliding using the Newmark method. The inclusion of these effects was critical in determining the extent of landsliding triggered. We found that for inertially triggered slope failures modeled by the Newmark method, the ground motions used to simulate landsliding must have broadband frequency content in order to capture the full slope displacement. We applied commonly used simpler methods based on ground‐motion prediction equations for the same scenario and found that they predicted far fewer landslides if only the mean values were used, but far more at the maximum range of the uncertainties, highlighting the danger of using just the mean values for such methods. Our results indicate that landsliding triggered by a large Seattle fault earthquake will be extensive and potentially devastating, causing direct losses and impeding recovery. The high impact of landsliding predicted by this simulation shows that this secondary effect of earthquakes should be studied with as much vigor as other earthquake effects.

  20. Assessment and interpretation of cross- and down-hole seismograms at the Paducah Gaseous Diffusion Plant

    Energy Technology Data Exchange (ETDEWEB)

    Staub, W.P.; Wang, J.C. (Oak Ridge National Lab., TN (United States)); Selfridge, R.J. (Automated Sciences Group, (United States))

    1991-09-01

    This paper is an assessment and interpretation of cross-and down-hole seismograms recorded at four sites in the vicinity of the Paducah Gaseous Diffusion Plant (PGDP). Arrival times of shear (S-) and compressional (P-) waves are recorded on these seismograms in milliseconds. Together with known distances between energy sources and seismometers lowered into boreholes, these arrival times are used to calculate S- and P-wave velocities in unconsolidated soils and sediments that overlie bedrock approximately 320 ft beneath PGDP. The soil columns are modified after an earlier draft by ERC Environmental and Energy Services Company (ERCE), 1990. In addition to S- and P- wave velocity estimates from this paper, the soil columns contain ERCE's lithologic and other geotechnical data for unconsolidated soils and sediments from the surface to bedrock. Soil columns for Sites 1 through 4 and a site location map are in Plates 1 through 5 of Appendix 6. The velocities in the four columns are input parameters for the SHAKE computer program, a nationally recognized computer model that simulates ground response of unconsolidated materials to earthquake generated seismic waves. The results of the SHAKE simulation are combined with predicted ground responses on rock foundations (caused by a given design earthquake) to predict ground responses of facilities with foundations placed on unconsolidated materials. 3 refs.

  1. Wavelet analysis of the seismograms for tsunami warning

    Directory of Open Access Journals (Sweden)

    A. Chamoli

    2010-10-01

    Full Text Available The complexity in the tsunami phenomenon makes the available warning systems not much effective in the practical situations. The problem arises due to the time lapsed in the data transfer, processing and modeling. The modeling and simulation needs the input fault geometry and mechanism of the earthquake. The estimation of these parameters and other aprior information increases the utilized time for making any warning. Here, the wavelet analysis is used to identify the tsunamigenesis of an earthquake. The frequency content of the seismogram in time scale domain is examined using wavelet transform. The energy content in high frequencies is calculated and gives a threshold for tsunami warnings. Only first few minutes of the seismograms of the earthquake events are used for quick estimation. The results for the earthquake events of Andaman Sumatra region and other historic events are promising.

  2. The Spontaneous Ray Log: A New Aid for Constructing Pseudo-Synthetic Seismograms

    Science.gov (United States)

    Quadir, Adnan; Lewis, Charles; Rau, Ruey-Juin

    2018-02-01

    Conventional synthetic seismograms for hydrocarbon exploration combine the sonic and density logs, whereas pseudo-synthetic seismograms are constructed with a density log plus a resistivity, neutron, gamma ray, or rarely a spontaneous potential log. Herein, we introduce a new technique for constructing a pseudo-synthetic seismogram by combining the gamma ray (GR) and self-potential (SP) logs to produce the spontaneous ray (SR) log. Three wells, each of which consisted of more than 1000 m of carbonates, sandstones, and shales, were investigated; each well was divided into 12 Groups based on formation tops, and the Pearson product-moment correlation coefficient (PCC) was calculated for each "Group" from each of the GR, SP, and SR logs. The highest PCC-valued log curves for each Group were then combined to produce a single log whose values were cross-plotted against the reference well's sonic ITT values to determine a linear transform for producing a pseudo-sonic (PS) log and, ultimately, a pseudo-synthetic seismogram. The range for the Nash-Sutcliffe efficiency (NSE) acceptable value for the pseudo-sonic logs of three wells was 78-83%. This technique was tested on three wells, one of which was used as a blind test well, with satisfactory results. The PCC value between the composite PS (SR) log with low-density correction and the conventional sonic (CS) log was 86%. Because of the common occurrence of spontaneous potential and gamma ray logs in many of the hydrocarbon basins of the world, this inexpensive and straightforward technique could hold significant promise in areas that are in need of alternate ways to create pseudo-synthetic seismograms for seismic reflection interpretation.

  3. Fast evaluation of complete synthetic SH seismograms based on asymptotic mode theory

    NARCIS (Netherlands)

    Bastians, M.W.J.M.

    1986-01-01

    In this thesis we have developed an asymptotic mode theory with the following features. 1) Complete synthetic SH seismograms can be evaluated for both realistic models of Earth and crust. 2) The method is of practical value and can be used even on small computers wi th reasonable computation

  4. Fast evaluation of complete synthetic SH seismograms based on asymptotic mode theory

    NARCIS (Netherlands)

    Bastians, M.W.J.M.

    1986-01-01

    In this thesis we have developed an asymptotic mode theory with the following features. 1) Complete synthetic SH seismograms can be evaluated for both realistic models of Earth and crust. 2) The method is of practical value and can be used even on small computers wi th reasonable computation times

  5. Development of XML Schema for Broadband Digital Seismograms and Data Center Portal

    Science.gov (United States)

    Takeuchi, N.; Tsuboi, S.; Ishihara, Y.; Nagao, H.; Yamagishi, Y.; Watanabe, T.; Yanaka, H.; Yamaji, H.

    2008-12-01

    There are a number of data centers around the globe, where the digital broadband seismograms are opened to researchers. Those centers use their own user interfaces and there are no standard to access and retrieve seismograms from different data centers using unified interface. One of the emergent technologies to realize unified user interface for different data centers is the concept of WebService and WebService portal. Here we have developed a prototype of data center portal for digital broadband seismograms. This WebService portal uses WSDL (Web Services Description Language) to accommodate differences among the different data centers. By using the WSDL, alteration and addition of data center user interfaces can be easily managed. This portal, called NINJA Portal, assumes three WebServices: (1) database Query service, (2) Seismic event data request service, and (3) Seismic continuous data request service. Current system supports both station search of database Query service and seismic continuous data request service. Data centers supported by this NINJA portal will be OHP data center in ERI and Pacific21 data center in IFREE/JAMSTEC in the beginning. We have developed metadata standard for seismological data based on QuakeML for parametric data, which has been developed by ETH Zurich, and XML-SEED for waveform data, which was developed by IFREE/JAMSTEC. The prototype of NINJA portal is now released through IFREE web page (http://www.jamstec.go.jp/pacific21/).

  6. The 5th July 1930 earthquake at Montilla (S Spain). Use of regionally recorded smoked paper seismograms

    Science.gov (United States)

    Batlló, J.; Stich, D.; Macià, R.; Morales, J.

    2009-04-01

    On the night of 5th July 1930 a damaging earthquake struck the town of Montilla (near Córdoba, S-Spain) and its surroundings. Magnitude estimation for this earthquake is M=5, and its epicentral intensity has been evaluated as VIII (MSK). Even it is an earthquake of moderate size, it is the largest one in-strumentally recorded in this region. This makes this event of interest for a better definition of the regional seismicity. For this reason we decided to study a new its source from the analysis of the available contemporary seismograms and related documents. A total of 25 seismograms from 11 seismic stations have been collected and digitized. Processing of some of the records has been difficult because they were obtained from microfilm or contemporary reproductions on journals. Most of them are on smoked paper and recorded at regional distances. This poses a good opportunity to test the limits of the use of such low frequency - low dynamics recorded seismograms for the study of regional events. Results are promising: Using such regional seismograms the event has been relocated, its magnitude recalculated (Mw 5.1) and inversion of waveforms to elucidate its focal mechanism has been performed. We present the results of this research and its consequences for the regional seismicity and we compare them with present smaller earthquakes occurred in the same place and with the results obtained for earthquakes of similar size occurred more to the East on 1951.

  7. Digital Filming of the Seismograms Held in the Jakarta Archives: A Pilot Program

    Science.gov (United States)

    Okal, E. A.; Kirby, S. H.

    2014-12-01

    Because of the long duration of most seismic cycles with respect to thehistory of seismological instrumentation,seismograms from the first half of the 20th century constitute an invaluableresource, allowing significant constraints on the regional chronologyof earthquake occurrence as well as the modern quantification of their sizethrough the calculation of seismic moments. This is especially true in theSouthern hemisphere which hosted few seismic stations before the 1930s. In this context, the preservation of seismograms in a digital format allowing their seamless exchange is an important challenge to the scientific community. Under funding from the Earth Observatory of Singapore, we initiated in July2014 a pilotproject, administered by IASPEI, to test the feasibility ofphotographically scanning records of the Wiechert and Bosch instruments operatedat the Jakarta (ex-Batavia) station since 1910 and archivedat the BMKG regional office in Ciputat. We used a 24 MP SONY alphaNEXT 7 camera with a nearly distortion-free wide angle lens mounted on a copystand with underside light-table illumination. We encounteredmany challenges, including the fragility of acidic paper,serious dark-brown age-toning of the paper, as well as many missing records.However, this pilot test showed that this inexpensive systemis effective in providing well-resolved waveforms, and reaped more than 500digital copies of seismograms of earthquakes earmarked for theirglobal or regional importance, going back to 1910.Including the compilation of metadata necessary for futuresearch capability, 15 to 20 seismograms can be scanned per hour.Following successful capacity building through on-site training of BMKG Staff,it is hoped that this project can be pursued at BMKG, and complementsimilar endeavors, especially in the critically important Southern Hemisphere,either ongoing (e.g., at Canberra, Silverton), or desirable (e.g., at Lower Hutt,La Paz).

  8. Simulation of seismograms in a 2-D viscoelastic Earth by pseudospectral methods

    Energy Technology Data Exchange (ETDEWEB)

    Carcione, Jose M [Istituto Nazionale di Oceanografia e di Geofisica Sperimentale (OGS), Trieste (Italy); Helle, Hans B [Norsk Hydro a.s., 0 and E Research Centre, Bergen (Norway); Seriani, Geza [Istituto Nazionale di Oceanografia e di Geofisica Sperimentale (OGS), Trieste (Italy); Plasencia Linares, Milton P [Facultad de Ciencias Astronomicas y Geofisicas, Universidad Nacional de La Plata, La Plata (Argentina)

    2005-04-15

    Using an improved global pseudospectral modeling algorithm we synthesize seismograms generated by oceanic and continental earthquakes. Attention is given to attenuation, to explicit modeling of boundary conditions at the ocean-bottom interface, simulation of the Rayleigh window and interface-wave propagation. The algorithm is based on Fourier and Chebyshev differential operators and a domain-decomposition technique - one grid for the fluid and another grid for the solid. Wave propagation in the oceanic and continent crusts and mantle is modeled by using a viscoelastic stress-strain relation based on memory variables. The main physical phenomena associated with an ocean-crust system are modeled, including Scholte waves, leaking Rayleigh waves, dispersive modes, and the Rayleigh-window phenomenon due to a minimum in the reflection coefficient of the ocean bottom, which has not been simulated with direct methods. In particular, we model Rayleigh modes (mainly the M11 mode), and coupled Rayleigh-Scholte waves, for which the dispersion relation is solved in simple cases. Also, we model the effects of random. [Spanish] El algoritmo de modulacion seudoespectral es mejorado y aplicado a la simulacion de sismogramas generados por sismos oceanicos y continentales, como atencion a la atenuacion y a la modelacion explicita de condiciones a la frontera en el fondo oceanico y a la simulacion de la ventana de Rayleigh y la propagacion en interfases. El algoritmo se basa en los operadores diferenciales de Fourier y de Chebyshev con una tecnica de decomposicion de dominios, una malla para el fluido y otra para el solido. Para la propagacion se usa una relacion de esfuerzo-deformacion basada en variables de memoria. Entre los fenomenos modelados se incluyen las ondas de Scholte, las ondas evanescentes de Rayleigh y los modos dispersivos, asi como la ventana de Rayleigh, un minimo del coeficiente de reflexion en el fondo oceanico que nunca ha sido simulado con metodos directos. Hemos

  9. Micro-seismicity induced by hydrocarbon production: contribution to localization of events and identification of the source mechanisms through the use of dynamic friction models; Contribution a la localisation des evenements et l'identification des mecanismes au foyer en micro-sismicite induite par l'exploitation d'hydrocarbures. Utilisation des modeles de frottement dynamique

    Energy Technology Data Exchange (ETDEWEB)

    Mohammedi, H.

    2002-11-01

    Oil production or any injection of fluid in a geological medium is likely to impose variations of stresses which might generate micro-seismicity. We examine whether the use of dynamic friction models could allow for a better determination of mechanics on the fault plane from borehole seismometers. We sought to identify the friction law model from seismogram observation. Before dealing with this inverse problem, we examined the direct problem generating synthetic seismograms at virtual stations, on the basis of a postulated friction law using the FD3D earthquake simulation code and the AXITRA radiation computation code. Treatment of two different laws, one of which is an original variation of the Dietrich-Ruina law, leads to similar seismograms. This might indicate that systematic inversion for the friction law only from seismogram observation might reveal difficult. (authors)

  10. Digitization of Nuclear Explosion Seismograms from the Former Soviet Union

    Science.gov (United States)

    2015-03-30

    seismograms recorded in the former Soviet Union was initiated in the 1990s under the International Science and Technology Centre ( ISTC ) project K-063...The Lamont-Doherty Observatory of Columbia University (LDEO) helped to organize that work, writing the proposal to ISTC , which involved the U.S.A...were determined under the ISTC CASRI Project. For Kyrgyzstan temporary stations the coordinates were based on reports and information provided by

  11. Experiment of Neutron Generation by Using Prototype D-D Neutron Generator

    International Nuclear Information System (INIS)

    Kim, In Jung; Kim, Suk Kwon; Park, Chang Su; Jung, Nam Suk; Jung, Hwa Dong; Park, Ji Young; Hwang, Yong Seok; Choi, H.D.

    2005-01-01

    Experiment of neutron generation was performed by using a prototype D-D neutron generator. The characteristics of D-D neutron generation in drive-in target was studied. The increment of neutron yield by increasing ion beam energy was investigated, too

  12. D-D neutron generator development at LBNL.

    Science.gov (United States)

    Reijonen, J; Gicquel, F; Hahto, S K; King, M; Lou, T-P; Leung, K-N

    2005-01-01

    The plasma and ion source technology group in Lawrence Berkeley National Laboratory is developing advanced, next generation D-D neutron generators. There are three distinctive developments, which are discussed in this presentation, namely, multi-stage, accelerator-based axial neutron generator, high-output co-axial neutron generator and point source neutron generator. These generators employ RF-induction discharge to produce deuterium ions. The distinctive feature of RF-discharge is its capability to generate high atomic hydrogen species, high current densities and stable and long-life operation. The axial neutron generator is designed for applications that require fast pulsing together with medium to high D-D neutron output. The co-axial neutron generator is aimed for high neutron output with cw or pulsed operation, using either the D-D or D-T fusion reaction. The point source neutron generator is a new concept, utilizing a toroidal-shaped plasma generator. The beam is extracted from multiple apertures and focus to the target tube, which is located at the middle of the generator. This will generate a point source of D-D, T-T or D-T neutrons with high output flux. The latest development together with measured data will be discussed in this article.

  13. E3D, 3-D Elastic Seismic Wave Propagation Code

    International Nuclear Information System (INIS)

    Larsen, S.; Harris, D.; Schultz, C.; Maddix, D.; Bakowsky, T.; Bent, L.

    2004-01-01

    1 - Description of program or function: E3D is capable of simulating seismic wave propagation in a 3D heterogeneous earth. Seismic waves are initiated by earthquake, explosive, and/or other sources. These waves propagate through a 3D geologic model, and are simulated as synthetic seismograms or other graphical output. 2 - Methods: The software simulates wave propagation by solving the elasto-dynamic formulation of the full wave equation on a staggered grid. The solution scheme is 4-order accurate in space, 2-order accurate in time

  14. Transdimensional inversion of scattered body waves for 1D S-wave velocity structure - Application to the Tengchong volcanic area, Southwestern China

    Science.gov (United States)

    Li, Mengkui; Zhang, Shuangxi; Bodin, Thomas; Lin, Xu; Wu, Tengfei

    2018-06-01

    Inversion of receiver functions is commonly used to recover the S-wave velocity structure beneath seismic stations. Traditional approaches are based on deconvolved waveforms, where the horizontal component of P-wave seismograms is deconvolved by the vertical component. Deconvolution of noisy seismograms is a numerically unstable process that needs to be stabilized by regularization parameters. This biases noise statistics, making it difficult to estimate uncertainties in observed receiver functions for Bayesian inference. This study proposes a method to directly invert observed radial waveforms and to better account for data noise in a Bayesian formulation. We illustrate its feasibility with two synthetic tests having different types of noises added to seismograms. Then, a real site application is performed to obtain the 1-D S-wave velocity structure beneath a seismic station located in the Tengchong volcanic area, Southwestern China. Surface wave dispersion measurements spanning periods from 8 to 65 s are jointly inverted with P waveforms. The results show a complex S-wave velocity structure, as two low velocity zones are observed in the crust and uppermost mantle, suggesting the existence of magma chambers, or zones of partial melt. The upper magma chambers may be the heart source that cause the thermal activity on the surface.

  15. Global adjoint tomography: first-generation model

    KAUST Repository

    Bozdağ, Ebru

    2016-09-23

    We present the first-generation global tomographic model constructed based on adjoint tomography, an iterative full-waveform inversion technique. Synthetic seismograms were calculated using GPU-accelerated spectral-element simulations of global seismic wave propagation, accommodating effects due to 3-D anelastic crust & mantle structure, topography & bathymetry, the ocean load, ellipticity, rotation, and self-gravitation. Fréchet derivatives were calculated in 3-D anelastic models based on an adjoint-state method. The simulations were performed on the Cray XK7 named \\'Titan\\', a computer with 18 688 GPU accelerators housed at Oak Ridge National Laboratory. The transversely isotropic global model is the result of 15 tomographic iterations, which systematically reduced differences between observed and simulated three-component seismograms. Our starting model combined 3-D mantle model S362ANI with 3-D crustal model Crust2.0. We simultaneously inverted for structure in the crust and mantle, thereby eliminating the need for widely used \\'crustal corrections\\'. We used data from 253 earthquakes in the magnitude range 5.8 ≤ M ≤ 7.0. We started inversions by combining ~30 s body-wave data with ~60 s surface-wave data. The shortest period of the surface waves was gradually decreased, and in the last three iterations we combined ~17 s body waves with ~45 s surface waves. We started using 180 min long seismograms after the 12th iteration and assimilated minor- and major-arc body and surface waves. The 15th iteration model features enhancements of well-known slabs, an enhanced image of the Samoa/Tahiti plume, as well as various other plumes and hotspots, such as Caroline, Galapagos, Yellowstone and Erebus. Furthermore, we see clear improvements in slab resolution along the Hellenic and Japan Arcs, as well as subduction along the East of Scotia Plate, which does not exist in the starting model. Point-spread function tests demonstrate that we are approaching the

  16. From 1D to 3D: A new route to fabricate tridimensional structures via photo-generation of silver networks

    NARCIS (Netherlands)

    Wang, Zhanhua; Shen, Huaizhong; Wu, Yuxin; Fang, Liping; Ye, Shunsheng; Wang, Zhaoyi; Liu, Wendong; Cheng, Zhongkai; Zhang, Junhu; Yang, Bai

    2015-01-01

    A rapid and cost effective method has been developed to fabricate 3 dimensional (3D) ordered structures by photo-generating silver networks inside a 1D layered heterogeneous laminate composed of poly(vinyl alcohol) (PVA) and poly(methyl methacrylate) (PMMA). By designing the photo-mask meticulously,

  17. Development of a compact D-D neutron generator

    Science.gov (United States)

    Huang, Z.-W.; Wang, J.-R.; Wei, Z.; Lu, X.-L.; Ma, Z.-W.; Ran, J.-L.; Zhang, Z.-M.; Yao, Z.-E.; Zhang, Y.

    2018-01-01

    A compact D-D neutron generator was developed at Lanzhou University, China. A duoplasmatron ion source was used to produce a higher-current deuteron beam. The deuteron beam could be accelerated up to 150 keV by a single accelerating gap, and bombarded on a pure molybdenum drive-in target to produce D-D fast neutron. A bias voltage between the target and the extraction-accelerating electrode was produced by a resistance to suppress the secondary electron from the target. The neutron generator has been operated for several hundred hours, and the performances were investigated. The available range of the deuteron beam current was 1.0-4.0 mA. EJ410 scintillator detector system was used to measure the fast neutron yields. D-D neutron yield could reach 2.48×108 n/s under the deuteron beam of 3 mA and 150 keV.

  18. 3D-Printed, All-in-One Evaporator for High-Efficiency Solar Steam Generation under 1 Sun Illumination.

    Science.gov (United States)

    Li, Yiju; Gao, Tingting; Yang, Zhi; Chen, Chaoji; Luo, Wei; Song, Jianwei; Hitz, Emily; Jia, Chao; Zhou, Yubing; Liu, Boyang; Yang, Bao; Hu, Liangbing

    2017-07-01

    Using solar energy to generate steam is a clean and sustainable approach to addressing the issue of water shortage. The current challenge for solar steam generation is to develop easy-to-manufacture and scalable methods which can convert solar irradiation into exploitable thermal energy with high efficiency. Although various material and structure designs have been reported, high efficiency in solar steam generation usually can be achieved only at concentrated solar illumination. For the first time, 3D printing to construct an all-in-one evaporator with a concave structure for high-efficiency solar steam generation under 1 sun illumination is used. The solar-steam-generation device has a high porosity (97.3%) and efficient broadband solar absorption (>97%). The 3D-printed porous evaporator with intrinsic low thermal conductivity enables heat localization and effectively alleviates thermal dissipation to the bulk water. As a result, the 3D-printed evaporator has a high solar steam efficiency of 85.6% under 1 sun illumination (1 kW m -2 ), which is among the best compared with other reported evaporators. The all-in-one structure design using the advanced 3D printing fabrication technique offers a new approach to solar energy harvesting for high-efficiency steam generation. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Fission multipliers for D-D/D-T neutron generators

    International Nuclear Information System (INIS)

    Lou, T.P.; Vujic, J.L.; Koivunoro, H.; Reijonen, J.; Leung, K.-N.

    2003-01-01

    A compact D-D/D-T fusion based neutron generator is being designed at the Lawrence Berkeley National Laboratory to have a potential yield of 10 12 D-D n/s and 10 14 D-T n/s. Because of its high neutron yield and compact size (∼20 cm in diameter by 4 cm long), this neutron generator design will be suitable for many applications. However, some applications required higher flux available from nuclear reactors and spallation neutron sources operated with GeV proton beams. In this study, a subcritical fission multiplier with k eff of 0.98 is coupled with the compact neutron generators in order to increase the neutron flux output. We have chosen two applications to show the gain in flux due to the use of fission multipliers--in-core irradiation and out-of-core irradiation. For the in-core irradiation, we have shown that a gain of ∼25 can be achieved in a positron production system using D-T generator. For the out-of-core irradiation, a gain of ∼17 times is obtained in Boron Neutron Capture Therapy (BNCT) using a D-D neutron generator. The total number of fission neutrons generated by a source neutron in a fission multiplier with k eff is ∼50. For the out-of-core irradiation, the theoretical maximum net multiplication is ∼30 due to the absorption of neutrons in the fuel. A discussion of the achievable multiplication and the theoretical multiplication will be presented in this paper

  20. Compact D-D/D-T neutron generators and their applications

    International Nuclear Information System (INIS)

    Lou, Tak Pui

    2003-01-01

    Neutron generators based on the 2 H(d,n) 3 He and 3 H(d,n) 4 He fusion reactions are the most commonly available neutron sources. The applications of current commercial neutron generators are often limited by their low neutron yield and their short operational lifetime. A new generation of D-D/D-T fusion-based neutron generators has been designed at Lawrence Berkeley National Laboratory (LBNL) by using high current ion beams hitting on a self-loading target that has a large surface area to dissipate the heat load. This thesis describes the rationale behind the new designs and their potential applications. A survey of other neutron sources is presented to show their advantages and disadvantages compared to the fusion-based neutron generator. A prototype neutron facility was built at LBNL to test these neutron generators. High current ion beams were extracted from an RF-driven ion source to produce neutrons. With an average deuteron beam current of 24 mA and an energy of 100 keV, a neutron yield of >10 9 n/s has been obtained with a D-D coaxial neutron source. Several potential applications were investigated by using computer simulations. The computer code used for simulations and the variance reduction techniques employed were discussed. A study was carried out to determine the neutron flux and resolution of a D-T neutron source in thermal neutron scattering applications for condensed matter experiments. An error analysis was performed to validate the scheme used to predict the resolution. With a D-T neutron yield of 10 14 n/s, the thermal neutron flux at the sample was predicted to be 7.3 x 10 5 n/cm 2 s. It was found that the resolution of cold neutrons was better than that of thermal neutrons when the duty factor is high. This neutron generator could be efficiently used for research and educational purposes at universities. Additional applications studied were positron production and Boron Neutron Capture Therapy (BNCT). The neutron flux required for positron

  1. Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate.

    Directory of Open Access Journals (Sweden)

    Roberto P Stock

    Full Text Available The toxicity of Loxosceles spider venom has been attributed to a rare enzyme, sphingomyelinase D, which transforms sphingomyelin to ceramide-1-phosphate. The bases of its inflammatory and dermonecrotic activity, however, remain unclear. In this work the effects of ceramide-1-phosphate on model membranes were studied both by in situ generation of this lipid using a recombinant sphingomyelinase D from the spider Loxosceles laeta and by pre-mixing it with sphingomyelin and cholesterol. The systems of choice were large unilamellar vesicles for bulk studies (enzyme kinetics, fluorescence spectroscopy and dynamic light scattering and giant unilamellar vesicles for fluorescence microscopy examination using a variety of fluorescent probes. The influence of membrane lateral structure on the kinetics of enzyme activity and the consequences of enzyme activity on the structure of target membranes containing sphingomyelin were examined. The findings indicate that: 1 ceramide-1-phosphate (particularly lauroyl ceramide-1-phosphate can be incorporated into sphingomyelin bilayers in a concentration-dependent manner and generates coexistence of liquid disordered/solid ordered domains, 2 the activity of sphingomyelinase D is clearly influenced by the supramolecular organization of its substrate in membranes and, 3 in situ ceramide-1-phosphate generation by enzymatic activity profoundly alters the lateral structure and morphology of the target membranes.

  2. Compact D-D/D-T neutron generators and their applications

    Energy Technology Data Exchange (ETDEWEB)

    Lou, Tak Pui [Univ. of California, Berkeley, CA (United States)

    2003-01-01

    Neutron generators based on the 2H(d,n)3He and 3H(d,n)4He fusion reactions are the most commonly available neutron sources. The applications of current commercial neutron generators are often limited by their low neutron yield and their short operational lifetime. A new generation of D-D/D-T fusion-based neutron generators has been designed at Lawrence Berkeley National Laboratory (LBNL) by using high current ion beams hitting on a self-loading target that has a large surface area to dissipate the heat load. This thesis describes the rationale behind the new designs and their potential applications. A survey of other neutron sources is presented to show their advantages and disadvantages compared to the fusion-based neutron generator. A prototype neutron facility was built at LBNL to test these neutron generators. High current ion beams were extracted from an RF-driven ion source to produce neutrons. With an average deuteron beam current of 24 mA and an energy of 100 keV, a neutron yield of >109 n/s has been obtained with a D-D coaxial neutron source. Several potential applications were investigated by using computer simulations. The computer code used for simulations and the variance reduction techniques employed were discussed. A study was carried out to determine the neutron flux and resolution of a D-T neutron source in thermal neutron scattering applications for condensed matter experiments. An error analysis was performed to validate the scheme used to predict the resolution. With a D-T neutron yield of 1014 n/s, the thermal neutron flux at the sample was predicted to be 7.3 x 105 n/cm2s. It was found that the resolution of cold neutrons was better than that of thermal neutrons when the duty factor is high. This neutron generator could be efficiently used for research and educational purposes at universities. Additional applications studied were positron production and

  3. Synthetic Seismograms Derived from Oceanographic Data in the Campeche Canyon, Deepwater Gulf of Mexico

    Science.gov (United States)

    Gonzalez-Orduno, A.; Fucugauchi, J. U.; Monreal, M.; Perez-Cruz, G.; Salas de León, D. A.

    2013-05-01

    The seismic reflection method has been successfully applied worldwide to investigate subsurface conditions to support important business decisions in the oil industry. When applied in the marine environment, useful reflection information is limited to events on and below the sea floor; Information from the water column, if any, is disregarded. Seismic oceanography is emerging as a new technique that utilize the reflection information within the water column to infer thermal-density contrasts associated with oceanographic processes, such as cyclonic-anticyclonic eddies, ascending-descending water flows, and water flows related to rapid topographic changes on the sea floor. A seismic investigation to infer such oceanographic changes in one sector of the Campeche Canyon is in progress as a research matter at the Instituto de Ciencias del Mar y Limnologia from the University of Mexico (UNAM). First steps of the investigation consisted of creating synthetic seismograms based on oceanographic information (temperature and density) derived from direct observation on a series of close spaced depth points along vertical profiles. Details of the selected algorithms used for the transformation of the oceanographic data to acoustic impedances data sets and further construction of synthetic seismograms on each site and their representation as synthetic seismic sections, are presented in this work, as well as the road ahead in the investigation.

  4. Parameters of Higuchi's method to characterize primary waves in some seismograms from the Mexican subduction zone

    Science.gov (United States)

    Gálvez-Coyt, Gonzalo; Muñoz-Diosdado, Alejandro; Peralta, José; Balderas-López, José; Angulo-Brown, Fernando

    2012-06-01

    Higuchi's method is a procedure that, if applied appropriately, can determine in a reliable way the fractal dimension D of time series; this fractal dimension permits to characterize the degree of correlation of the series. However, when analyzing some time series with Higuchi's method, there are oscillations at the right-hand side of the graph, which can cause a mistaken determination of the fractal dimension. In this work, an appropriate explanation is given to this type of behaviour. Using the seismogram as a time series and the properties of the P and S waves, it is possible to use the properties of Higuchi's method to previously detect the arrival of the earthquake shacking stage, some seconds in advance, approximately 30-35 s in the case of Mexico City. Thus, we propose the Higuchi's method to characterize and detect the P waves in order to estimate the strength of the forthcoming S waves.

  5. CRISP. Functional Specifications of electric Networks with high degrees of distributed generation. Deliverable D1.1

    International Nuclear Information System (INIS)

    Fontela, M.; Bacha, S.; Hadsjaid, N.; Andrieu, C.

    2007-09-01

    The deliverable D 1.1 is the first step in the project. This D 1.1 deliverable treats the different components: networks, generation sources and also the actors present in the energy market. The French system is usually commented but comments about the other countries uses are also mentioned. Special attention has been paid to the Dutch system, and a comparison is made between the French and the Dutch system. The main goal of this work is to describe the electric system and its components. Also a benchmarking model is proposed in order to start the studies of the different work package. This benchmarking model implies: the transmission, sub-transmission and distribution electric sub-systems. From this model, different scenarios of perturbations are studied. These scenarios correspond to different framework times (transient and steady states) and they could become fatal for the system operation

  6. AUTOMATIC MESH GENERATION OF 3-D GEOMETRIC MODELS

    Institute of Scientific and Technical Information of China (English)

    刘剑飞

    2003-01-01

    In this paper the presentation of the ball-packing method is reviewed,and a scheme to generate mesh for complex 3-D geometric models is given,which consists of 4 steps:(1)create nodes in 3-D models by ball-packing method,(2)connect nodes to generate mesh by 3-D Delaunay triangulation,(3)retrieve the boundary of the model after Delaunay triangulation,(4)improve the mesh.

  7. A D-D neutron generator using a titanium drive-in target

    International Nuclear Information System (INIS)

    Kim, I.J.; Jung, N.S.; Jung, H.D.; Hwang, Y.S.; Choi, H.D.

    2008-01-01

    A D-D neutron generator was developed with an intensity of 10 8 n/s. A helicon plasma ion source was used to produce a large current deuteron beam, and neutrons were generated by irradiating the deuteron beam on a titanium drive-in target made of commercial pure titanium. The neutron generator was test-run for several hundred hours, and the performances were investigated. The available range of the deuteron beam current was 0.8-8 mA and the beam could be accelerated up to 97.5 keV. The maximum neutron generation rate in the test-runs was 1.9 x 10 8 n/s, which was achieved by irradiating a 7.6 mA deuteron beam at 94.0 keV on a 0.5 mm-thick target. The operation of the neutron generator was fairly stable, such that the neutron generation rate was not altered by high voltage breakdowns during the test-runs. Neutron generation efficiency was rated as low as 10% when compared to an ideal case of irradiating a 100% monatomic deuteron beam on a perfect TiD 2 target. Factors causing the low efficiency were suggested and discussed

  8. N = (2,0) self-dual non-Abelian tensor multiplet in D = 3 + 3 generates N = (1,1) self-dual systems in D = 2 + 2

    Science.gov (United States)

    Nishino, Hitoshi; Rajpoot, Subhash

    2018-03-01

    We formulate an N = (2 , 0) system in D = 3 + 3 dimensions consisting of a Yang-Mills (YM)-multiplet (ˆ μ ˆ IA, λˆI), a self-dual non-Abelian tensor multiplet (ˆ μ ˆ ν ˆ IB, χˆI ,φˆI), and an extra vector multiplet (C ˆ μ ˆ IC, ρˆI). We next perform the dimensional reductions of this system into D = 2 + 2, and obtain N = (1 , 1) systems with a self-dual YM-multiplet (AIμ ,λI), a self-dual tensor multiplet (BIμν , χI , φI), and an extra vector multiplet (CIμ , ρI). In D = 2 + 2, we reach two distinct theories: 'Theory-I' and 'Theory-II'. The former has the self-dual field-strength Hμν(+)I of CIμ already presented in our recent paper, while the latter has anti-self-dual field strength Hμν(-)I. As an application, we show that Theory-II actually generates supersymmetric-KdV equations in D = 1 + 1. Our result leads to a new conclusion that the D = 3 + 3 theory with non-Abelian tensor multiplet can be a 'Grand Master Theory' for self-dual multiplet and self-dual YM-multiplet in D = 2 + 2, that in turn has been conjectured to be the 'Master Theory' for all supersymmetric integrable theories in D ≤ 3.

  9. AUTOMATIC MESH GENERATION OF 3—D GEOMETRIC MODELS

    Institute of Scientific and Technical Information of China (English)

    刘剑飞

    2003-01-01

    In this paper the presentation of the ball-packing method is reviewed, and a schemeto generate mesh for complex 3-D geometric models is given, which consists of 4 steps: (1) createnodes in 3-D models by ball-packing method, (2) connect nodes to generate mesh by 3-D Delaunaytriangulation, (3) retrieve the boundary of the model after Delaunay triangulation, (4) improve themesh.

  10. Comparison of collimated blue-light generation in 85Rb atoms via the D1 and D2 lines

    Science.gov (United States)

    Prajapati, Nikunj; Akulshin, Alexander M.; Novikova, Irina

    2018-05-01

    We experimentally studied the characteristics of the collimated blue light (CBL) produced in ${}^{85}$Rb vapor by two resonant laser fields exciting atoms into the $5D_{3/2}$ state, using either the $5P_{1/2}$ or the $5P_{3/2}$ intermediate state. We compared the CBL output at different values of frequency detunings, powers, and polarizations of the pump lasers in these two cases, and confirmed the observed trends using a simple theoretical model. We also demonstrated that the addition of the repump laser, preventing the accumulation of atomic population in the uncoupled hyperfine ground state, resulted in nearly an order of magnitude increase in CBL power output. Overall, we found that the $5S_{1/2} - 5P_{1/2} - 5D_{3/2}$ excitation pathway results in stronger CBL generation, as we detected up to $4.25~\\mu$W using two pumps of the same linear polarization. The optimum CBL output for the $5S_{1/2} - 5P_{3/2} - 5D_{3/2}$ excitation pathway required the two pump lasers to have the same circular polarization, but resulted only in a maximum CBL power of $450$~nW.

  11. Current Status and Progress of Developing a D-D Neutron Generator

    International Nuclear Information System (INIS)

    Kim, In-Jung; Jung, Hwa-Dong; Park, Chang-Su; Jung, Nam-Suk; Chung, Kyoung-Jae; Hwang, Yong-Seok; Choi, H. D.

    2006-01-01

    The research to develop a D-D neutron generator was begun in 2001. A prototype device was built in 2004, and partly modified in 2005. By using the modified prototype D-D neutron generator, neutron generation runs were performed, and the characteristics of D-D neutron generation was investigated. The final goal of maximum neutron yield is 10 8 n/s, while a yield of 6.5x10 7 n/s has been achieved. Here, the results of neutron generation runs performed by using the modified prototype device are summarized, and the feature of a new ion source to be tested in weeks is briefly described

  12. Refinement of parameters of weak nuclear explosions conducted at the Semipalatinsk test site on the basis of historical seismograms study

    Science.gov (United States)

    Sokolova, Inna

    2014-05-01

    Many researchers working in the field of monitoring and discriminating of nuclear tests encounter the problem of lacking in seismic catalogues the information about source parameters for weak nuclear explosions. As usual, the information about origin time, coordinates and magnitude is absent, there is information about date, approximate coordinates and information about explosion yield. Huge work conducted on recovery of parameters of small underground nuclear explosions conducted at the Semipalatinsk Test Site using records of analogue seismic stations of the USSR located at regional distances was conducted by V. Khalturin, T. Rayutian, P. Richards (Pure and Applied Geophysics, 2001). However, if underground nuclear explosions are studied and described in literature quite well, then air and contact explosions were small and were not recorded by standard permanent seismic stations. In 1961-1962 maximum number of air and contact explosions was conducted at Opytnoye polye site of the STS. We managed to find and analyze additional seismic data from some temporary and permanent stations. That time IPE AS USSR installed a network of high-sensitive stations along Pamir-Baykal profile to study earth crust structure and upper mantle, the profile length was 3500 km. Epicentral distance from some stations of the profile to Opytnoye polye was 300-400 km. In addition, a permanent seismic station Semipalatinsk (SEM) located 175 km away from the site started its operation. The seismograms from this station became available recently. The digitized historical seismograms allowed to recover and add parameters for more than 36 air and surface explosions. Origin time, coordinates, magnitudes mpv, MLV and energy class K were determined for explosions. A regional travel-time curve for Central Kazakhstan constructed using records of calibration chemical explosions conducted at the STS in 1997-2000 and ground-truth underground nuclear explosions was used to determine kinematic parameters

  13. Wavelet transform analysis of transient signals: the seismogram and the electrocardiogram

    Energy Technology Data Exchange (ETDEWEB)

    Anant, K.S.

    1997-06-01

    In this dissertation I quantitatively demonstrate how the wavelet transform can be an effective mathematical tool for the analysis of transient signals. The two key signal processing applications of the wavelet transform, namely feature identification and representation (i.e., compression), are shown by solving important problems involving the seismogram and the electrocardiogram. The seismic feature identification problem involved locating in time the P and S phase arrivals. Locating these arrivals accurately (particularly the S phase) has been a constant issue in seismic signal processing. In Chapter 3, I show that the wavelet transform can be used to locate both the P as well as the S phase using only information from single station three-component seismograms. This is accomplished by using the basis function (wave-let) of the wavelet transform as a matching filter and by processing information across scales of the wavelet domain decomposition. The `pick` time results are quite promising as compared to analyst picks. The representation application involved the compression of the electrocardiogram which is a recording of the electrical activity of the heart. Compression of the electrocardiogram is an important problem in biomedical signal processing due to transmission and storage limitations. In Chapter 4, I develop an electrocardiogram compression method that applies vector quantization to the wavelet transform coefficients. The best compression results were obtained by using orthogonal wavelets, due to their ability to represent a signal efficiently. Throughout this thesis the importance of choosing wavelets based on the problem at hand is stressed. In Chapter 5, I introduce a wavelet design method that uses linear prediction in order to design wavelets that are geared to the signal or feature being analyzed. The use of these designed wavelets in a test feature identification application led to positive results. The methods developed in this thesis; the

  14. HypGrid2D. A 2-d mesh generator

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, N N

    1998-03-01

    The implementation of a hyperbolic mesh generation procedure, based on an equation for orthogonality and an equation for the cell face area is described. The method is fast, robust and gives meshes with good smoothness and orthogonality. The procedure is implemented in a program called HypGrid2D. The HypGrid2D program is capable of generating C-, O- and `H`-meshes for use in connection with the EllipSys2D Navier-Stokes solver. To illustrate the capabilities of the program, some test examples are shown. First a series of C-meshes are generated around a NACA-0012 airfoil. Secondly a series of O-meshes are generated around a NACA-65-418 airfoil. Finally `H`-meshes are generated over a Gaussian hill and a linear escarpment. (au)

  15. Development of a 1D thermal-hydraulic analysis code for once-through steam generator in SMRs using straight tubes

    Energy Technology Data Exchange (ETDEWEB)

    Park, Youngjae; Kim, Iljin; Kim, Hyungdae [Kyung Hee University, Yongin (Korea, Republic of)

    2015-10-15

    Diverse integral/small-modular reactors (SMRs) have been developed. Once-through steam generator (OTSG) which generates superheated steam without steam separator and dryer was used in the SMRs to reduce volume of steam generator. It would be possible to design a new steam generator with best estimate thermal-hydraulic codes such as RELAP and MARS. However, it is not convenience to use the general purpose thermal-hydraulic analysis code to design a specific component of nuclear power plants. A widely used simulation tool for thermal-hydraulic analysis of drum-type steam generators is ATHOS, which allows 3D analysis. On the other hand, a simple 1D thermal-hydraulic analysis code might be accurate enough for the conceptual design of OTSG. In this study, thermal-hydraulic analysis code for conceptual design of OTSG was developed using 1D homogeneous equilibrium model (HEM). A benchmark calculation was also conducted to verify and validate the prediction accuracy of the developed code by comparing with the analysis results with MARS. Finally, conceptual design of OTSG was conducted by the developed code. A simple 1D thermal-hydraulic analysis code was developed for the purpose of conceptual design OTSG for SMRs. A set of benchmark calculations was conducted to verify and validate the analysis accuracy of the developed code by comparing results obtained with a best-estimated thermal-hydraulic analysis code, MARS. Finally, analysis of two different OTSG design concepts with superheating and recirculation was demonstrated using the developed code.

  16. The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice

    Science.gov (United States)

    Ju, Xiang-Chun; Hou, Qiong-Qiong; Sheng, Ai-Li; Wu, Kong-Yan; Zhou, Yang; Jin, Ying; Wen, Tieqiao; Yang, Zhengang; Wang, Xiaoqun; Luo, Zhen-Ge

    2016-01-01

    Cortical expansion and folding are often linked to the evolution of higher intelligence, but molecular and cellular mechanisms underlying cortical folding remain poorly understood. The hominoid-specific gene TBC1D3 undergoes segmental duplications during hominoid evolution, but its role in brain development has not been explored. Here, we found that expression of TBC1D3 in ventricular cortical progenitors of mice via in utero electroporation caused delamination of ventricular radial glia cells (vRGs) and promoted generation of self-renewing basal progenitors with typical morphology of outer radial glia (oRG), which are most abundant in primates. Furthermore, down-regulation of TBC1D3 in cultured human brain slices decreased generation of oRGs. Interestingly, localized oRG proliferation resulting from either in utero electroporation or transgenic expression of TBC1D3, was often found to underlie cortical regions exhibiting folding. Thus, we have identified a hominoid gene that is required for oRG generation in regulating the cortical expansion and folding. DOI: http://dx.doi.org/10.7554/eLife.18197.001 PMID:27504805

  17. Underground storage tank 291-D1U1: Closure plan

    Energy Technology Data Exchange (ETDEWEB)

    Mancieri, S.; Giuntoli, N.

    1993-09-01

    The 291-D1U1 tank system was installed in 1983 on the north side of Building 291. It supplies diesel fuel to the Building 291 emergency generator and air compressor. The emergency generator and air compressor are located southwest and southeast, respectively, of the tank (see Appendix B, Figure 2). The tank system consists of a single-walled, 2,000- gallon, fiberglass tank and a fuel pump system, fill pipe, vent pipe, electrical conduit, and fuel supply and return piping. The area to be excavated is paved with asphalt and concrete. It is not known whether a concrete anchor pad is associated with this tank. Additionally, this closure plan assumes that the diesel tank is below the fill pad. The emergency generator and air compressor for Building 291 and its associated UST, 291-D1U1, are currently in use. The generator and air compressor will be supplied by a temporary above-ground fuel tank prior to the removal of 291-D1U1. An above-ground fuel tank will be installed as a permanent replacement for 291-D1U1. The system was registered with the State Water Resources Control Board on June 27, 1984, as 291-41D and has subsequently been renamed 291-D1U1. Figure 1 (see Appendix B) shows the location of the 291-D1U1 tank system in relation to the Lawrence Livermore National Laboratory (LLNL). Figure 2 (see Appendix B) shows the 291-D1U1 tank system in relation to Building 291. Figure 3 (see Appendix B) shows a plan view of the 291-D1U1 tank system.

  18. Stereoscopic 3D graphics generation

    Science.gov (United States)

    Li, Zhi; Liu, Jianping; Zan, Y.

    1997-05-01

    Stereoscopic display technology is one of the key techniques of areas such as simulation, multimedia, entertainment, virtual reality, and so on. Moreover, stereoscopic 3D graphics generation is an important part of stereoscopic 3D display system. In this paper, at first, we describe the principle of stereoscopic display and summarize some methods to generate stereoscopic 3D graphics. Secondly, to overcome the problems which came from the methods of user defined models (such as inconvenience, long modifying period and so on), we put forward the vector graphics files defined method. Thus we can design more directly; modify the model simply and easily; generate more conveniently; furthermore, we can make full use of graphics accelerator card and so on. Finally, we discuss the problem of how to speed up the generation.

  19. Duration of Tsunami Generation Longer than Duration of Seismic Wave Generation in the 2011 Mw 9.0 Tohoku-Oki Earthquake

    Science.gov (United States)

    Fujihara, S.; Korenaga, M.; Kawaji, K.; Akiyama, S.

    2013-12-01

    We try to compare and evaluate the nature of tsunami generation and seismic wave generation in occurrence of the 2011 Tohoku-Oki earthquake (hereafter, called as TOH11), in terms of two type of moment rate functions, inferred from finite source imaging of tsunami waveforms and seismic waveforms. Since 1970's, the nature of "tsunami earthquakes" has been discussed in many researches (e.g. Kanamori, 1972; Kanamori and Kikuchi, 1993; Kikuchi and Kanamori, 1995; Ide et al., 1993; Satake, 1994) mostly based on analysis of seismic waveform data , in terms of the "slow" nature of tsunami earthquakes (e.g., the 1992 Nicaragura earthquake). Although TOH11 is not necessarily understood as a tsunami earthquake, TOH11 is one of historical earthquakes that simultaneously generated large seismic waves and tsunami. Also, TOH11 is one of earthquakes which was observed both by seismic observation network and tsunami observation network around the Japanese islands. Therefore, for the purpose of analyzing the nature of tsunami generation, we try to utilize tsunami waveform data as much as possible. In our previous studies of TOH11 (Fujihara et al., 2012a; Fujihara et al., 2012b), we inverted tsunami waveforms at GPS wave gauges of NOWPHAS to image the spatio-temporal slip distribution. The "temporal" nature of our tsunami source model is generally consistent with the other tsunami source models (e.g., Satake et al, 2013). For seismic waveform inversion based on 1-D structure, here we inverted broadband seismograms at GSN stations based on the teleseismic body-wave inversion scheme (Kikuchi and Kanamori, 2003). Also, for seismic waveform inversion considering the inhomogeneous internal structure, we inverted strong motion seismograms at K-NET and KiK-net stations, based on 3-D Green's functions (Fujihara et al., 2013a; Fujihara et al., 2013b). The gross "temporal" nature of our seismic source models are generally consistent with the other seismic source models (e.g., Yoshida et al

  20. Production of 14 MeV neutrons from D-D neutron generators

    International Nuclear Information System (INIS)

    Cecil, F.E.; Nieschmidt, E.B.

    1986-01-01

    The production of 14 MeV neutrons from a D-D neutron generator resulting from tritium buildup from the d(d,p)t reaction in the target is discussed. The effect of the 14 MeV neutrons on fast neutron activation analysis with D-D neutron generators is evaluated. (orig.)

  1. Generation of narrow-band polarization-entangled photon pairs at a rubidium D1 line

    International Nuclear Information System (INIS)

    Tian Long; Li Shujing; Yuan Haoxiang; Wang Hai

    2016-01-01

    Using the process of cavity-enhanced spontaneous parametric down-conversion (SPDC), we generate a narrow-band polarization-entangled photon pair resonant on the rubidium (Rb) D1 line (795 nm). The degenerate single-mode photon pair is selected by multiple temperature controlled etalons. The linewidth of generated polarization-entangled photon pairs is 15 MHz which matches the typical atomic memory bandwidth. The measured Bell parameter for the polarization-entangled photons S = 2.73 ± 0.04 which violates the Bell-CHSH inequality by ∼18 standard deviations. The presented entangled photon pair source could be utilized in quantum communication and quantum computing based on quantum memories in atomic ensemble. (author)

  2. On-Line Generation of 3D-Waves

    DEFF Research Database (Denmark)

    Frigaard, Peter

    1992-01-01

    The paper describes the technique of filtering white noise for on-line generation of 3D-waves on a small computer in the laboratory. The wave generation package is implemented and tested in the 3D-wave basin at the University of Aalborg.......The paper describes the technique of filtering white noise for on-line generation of 3D-waves on a small computer in the laboratory. The wave generation package is implemented and tested in the 3D-wave basin at the University of Aalborg....

  3. Development of a D-D Neutron Generator

    International Nuclear Information System (INIS)

    Kim, In Jung; Jung, Hwa Dong; Park, Chang Su; Jung, Nam Suk; Jung, Soon Wook; Hwang, Y. S.; Choi, H. D.

    2007-01-01

    To enhance neutron yield, the ion source of the D-D neutron generator is replaced by a large current helicon plasma ion source. Current and energy of deuteron beam are increased, and hence neutron yield is enhanced. The maximum neutron yield is 2x10 8 n/s

  4. D Surface Generation from Aerial Thermal Imagery

    Science.gov (United States)

    Khodaei, B.; Samadzadegan, F.; Dadras Javan, F.; Hasani, H.

    2015-12-01

    Aerial thermal imagery has been recently applied to quantitative analysis of several scenes. For the mapping purpose based on aerial thermal imagery, high accuracy photogrammetric process is necessary. However, due to low geometric resolution and low contrast of thermal imaging sensors, there are some challenges in precise 3D measurement of objects. In this paper the potential of thermal video in 3D surface generation is evaluated. In the pre-processing step, thermal camera is geometrically calibrated using a calibration grid based on emissivity differences between the background and the targets. Then, Digital Surface Model (DSM) generation from thermal video imagery is performed in four steps. Initially, frames are extracted from video, then tie points are generated by Scale-Invariant Feature Transform (SIFT) algorithm. Bundle adjustment is then applied and the camera position and orientation parameters are determined. Finally, multi-resolution dense image matching algorithm is used to create 3D point cloud of the scene. Potential of the proposed method is evaluated based on thermal imaging cover an industrial area. The thermal camera has 640×480 Uncooled Focal Plane Array (UFPA) sensor, equipped with a 25 mm lens which mounted in the Unmanned Aerial Vehicle (UAV). The obtained results show the comparable accuracy of 3D model generated based on thermal images with respect to DSM generated from visible images, however thermal based DSM is somehow smoother with lower level of texture. Comparing the generated DSM with the 9 measured GCPs in the area shows the Root Mean Square Error (RMSE) value is smaller than 5 decimetres in both X and Y directions and 1.6 meters for the Z direction.

  5. Development and characterization of a D-D fast neutron generator for imaging applications.

    Science.gov (United States)

    Adams, Robert; Bort, Lorenz; Zboray, Robert; Prasser, Horst-Michael

    2015-02-01

    The experimental characterization of a pulsed D-D fast neutron generator designed for fan-beam tomography applications is presented. Using Monte Carlo simulations the response of an LB6411 neutron probe was related to the neutron generator output. The yield was measured to be up to ∼10(7) neutrons/s. An aluminum block was moved stepwise between the source and a BC400 plastic scintillator detector in order to measure an edge response. This edge response was related to the neutron emitting spot size using Monte Carlo simulations and a simplified geometry-based model. The experimentally determined spot size of 2.2 mm agreed well with the simulated value of 1.5 mm. The time-dependence of pulsed output for various operating conditions was also measured. The neutron generator was found to satisfy design requirements for a planned fast neutron tomography arrangement based on a plastic scintillator detector array which is expected to be capable of producing 2D tomograms with a resolution of ∼1.5 mm. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Modification of Prototype D-D Neutron Generator

    International Nuclear Information System (INIS)

    Kim, In Jung; Kim, Suk Kwon; Park, Chang Su; Jung, Nam Suk; Jung, Hwa Dong; Park, Ji Young; Hwang, Yong Seok; Choi, H. D.

    2005-01-01

    The prototype D-D neutron generator was modified in order to enhance the neutron yield. The distance from ion source to target was reduced to increase the ion beam current at target position. Thick Ti target was replaced by thin Ti target which was vacuum-deposited on Cu substrate in order to enhance the target cooling. Performance of the modified device was tested

  7. Holographic memory system based on projection recording of computer-generated 1D Fourier holograms.

    Science.gov (United States)

    Betin, A Yu; Bobrinev, V I; Donchenko, S S; Odinokov, S B; Evtikhiev, N N; Starikov, R S; Starikov, S N; Zlokazov, E Yu

    2014-10-01

    Utilization of computer generation of holographic structures significantly simplifies the optical scheme that is used to record the microholograms in a holographic memory record system. Also digital holographic synthesis allows to account the nonlinear errors of the record system to improve the microholograms quality. The multiplexed record of holograms is a widespread technique to increase the data record density. In this article we represent the holographic memory system based on digital synthesis of amplitude one-dimensional (1D) Fourier transform holograms and the multiplexed record of these holograms onto the holographic carrier using optical projection scheme. 1D Fourier transform holograms are very sensitive to orientation of the anamorphic optical element (cylindrical lens) that is required for encoded data object reconstruction. The multiplex record of several holograms with different orientation in an optical projection scheme allowed reconstruction of the data object from each hologram by rotating the cylindrical lens on the corresponding angle. Also, we discuss two optical schemes for the recorded holograms readout: a full-page readout system and line-by-line readout system. We consider the benefits of both systems and present the results of experimental modeling of 1D Fourier holograms nonmultiplex and multiplex record and reconstruction.

  8. Fully digital 1-D, 2-D and 3-D multiscroll chaos as hardware pseudo random number generators

    KAUST Repository

    Mansingka, Abhinav S.

    2012-10-07

    This paper introduces the first fully digital implementation of 1-D, 2-D and 3-D multiscroll chaos using the sawtooth nonlinearity in a 3rd order ODE with the Euler approximation. Systems indicate chaotic behaviour through phase space boundedness and positive Lyapunov exponent. Low-significance bits form a PRNG and pass all tests in the NIST SP. 800-22 suite without post-processing. Real-time control of the number of scrolls allows distinct output streams with 2-D and 3-D multiscroll chaos enabling greater controllability. The proposed PRNGs are experimentally verified on a Xilinx Virtex 4 FPGA with logic utilization less than 1.25%, throughput up to 5.25 Gbits/s and up to 512 distinct output streams with low cross-correlation.

  9. Fully digital 1-D, 2-D and 3-D multiscroll chaos as hardware pseudo random number generators

    KAUST Repository

    Mansingka, Abhinav S.; Radwan, Ahmed Gomaa; Salama, Khaled N.

    2012-01-01

    This paper introduces the first fully digital implementation of 1-D, 2-D and 3-D multiscroll chaos using the sawtooth nonlinearity in a 3rd order ODE with the Euler approximation. Systems indicate chaotic behaviour through phase space boundedness

  10. Regulation of primary cytotoxic T lymphocyte responses generated during mixed leukocyte culture with H-2d identical Qa-1-disparate cells

    International Nuclear Information System (INIS)

    Huston, D.P.; Tavana, G.; Rich, R.R.; Gressens, S.E.

    1986-01-01

    Cytotoxic lymphocyte (CTL) responses are not usually generated during primary mixed leukocyte culture (MLC) with H-2 identical cells. Thus NZB mice are unusual in that their spleen cells do mount CTL responses during primary MLC with H-2d identical stimulator cells; the predominant target antigen for these NZB responses is Qa-1b. Considering the numerous immunoregulatory defects in NZB mice, we postulated that these NZB anti-Qa-1 primary CTL responses were due to an abnormality in T suppressor cell activity. Cellular interactions capable of suppressing NZB anti-Qa-1 primary CTL responses were investigated by using one-way and two-way MLC with spleen cells from NZB mice and other H-2d strains. Although H-2d identical one-way MLC with the use of NZB responders resulted in substantial CTL responses, only minimal CTL responses were detected from two-way MLC with the use of NZB spleen cells plus nonirradiated spleen cells from other H-2d mice. Thus the presence of non-NZB spleen cells in the two-way H-2d identical MLC prevented the generation of NZB CTL. Noncytotoxic mechanisms were implicated in the suppression of the NZB CTL responses during two-way MLC, because only minimal CTL activity was generated when NZB spleen cells were cultured with semiallogeneic, H-2d identical (e.g., NZB X BALB) F1 spleen cells. The observed suppression could be abrogated with as little as 100 rad gamma-irradiation to the non-NZB spleen cells. The phenotype of these highly radiosensitive spleen cells was Thy-1+, Lyt-1+, Lyt-2-, L3T4+. The functional presence of these cells in the spleens of semiallogeneic, H-2d identical F1 mice indicated that their deficiency in NZB mice was a recessive trait. These data suggest that NZB mice lack an L3T4+ cell present in the spleens of normal mice that is capable of suppressing primary anti-Qa-1 CTL responses

  11. The SCEC Broadband Platform: Open-Source Software for Strong Ground Motion Simulation and Validation

    Science.gov (United States)

    Silva, F.; Goulet, C. A.; Maechling, P. J.; Callaghan, S.; Jordan, T. H.

    2016-12-01

    The Southern California Earthquake Center (SCEC) Broadband Platform (BBP) is a carefully integrated collection of open-source scientific software programs that can simulate broadband (0-100 Hz) ground motions for earthquakes at regional scales. The BBP can run earthquake rupture and wave propagation modeling software to simulate ground motions for well-observed historical earthquakes and to quantify how well the simulated broadband seismograms match the observed seismograms. The BBP can also run simulations for hypothetical earthquakes. In this case, users input an earthquake location and magnitude description, a list of station locations, and a 1D velocity model for the region of interest, and the BBP software then calculates ground motions for the specified stations. The BBP scientific software modules implement kinematic rupture generation, low- and high-frequency seismogram synthesis using wave propagation through 1D layered velocity structures, several ground motion intensity measure calculations, and various ground motion goodness-of-fit tools. These modules are integrated into a software system that provides user-defined, repeatable, calculation of ground-motion seismograms, using multiple alternative ground motion simulation methods, and software utilities to generate tables, plots, and maps. The BBP has been developed over the last five years in a collaborative project involving geoscientists, earthquake engineers, graduate students, and SCEC scientific software developers. The SCEC BBP software released in 2016 can be compiled and run on recent Linux and Mac OS X systems with GNU compilers. It includes five simulation methods, seven simulation regions covering California, Japan, and Eastern North America, and the ability to compare simulation results against empirical ground motion models (aka GMPEs). The latest version includes updated ground motion simulation methods, a suite of new validation metrics and a simplified command line user interface.

  12. First PGAA and NAA experimental results from a compact high intensity D-D neutron generator

    International Nuclear Information System (INIS)

    Reijonen, J.; Leung, K.-N.; Firestone, R.B.; English, J.A.; Perry, D.L.; Smith, A.; Gicquel, F.; Sun, M.; Bandong, B.; Garabedian, G.; Revay, Zs.; Szentmiklosi, L.; Molnar, G.

    2003-01-01

    Various types of neutron generator systems have been designed and tested at the Plasma and Ion Source Technology Group at Lawrence Berkeley National Laboratory. These generators are based on a D-D fusion reaction. These high power D-D neutron generators can provide neutron fluxes in excess of the current state of the art D-T neutron generators, without the use of pre-loaded targets or radioactive tritium gas. Safe and reliable long-life operations are the typical features of these D-D generators. All of the neutron generators developed in the Plasma and Ion Source Technology Group are utilizing powerful RF-induction discharge to generate the deuterium plasma. One of the advantages of using the RF-induction discharge is it's ability to generate high fraction of atomic ions from molecular gases, and the ability to generate high plasma densities for high extractable ion current from relatively small discharge volume

  13. Utilization of a pulsed D-T neutron generator

    International Nuclear Information System (INIS)

    Vilaithong, T.; Singkarat, S.; Tippawan, U.

    2000-01-01

    In the past two decades the IAEA has supported the establishment of neutron laboratories in many developing countries by providing small D-T neutron generators. The neutron generator is basically a low energy (100-400 keV) ion accelerator capable of producing a continuous beam of deuterons with a current in the range between 1-2.5 mA. These neutron generators are primarily intended to be used for fast neutron activation analysis. This paper describes the utilization of a 14 MeV neutron generator in continuous and pulsed beam modes in applied neutron physics program at Chiang Mai University. (author)

  14. A D-D/D-T fusion reaction based neutron generator system for liver tumor BNCT

    International Nuclear Information System (INIS)

    Koivunoro, H.; Lou, T.P.; Leung, K. N.; Reijonen, J.

    2003-01-01

    Boron-neutron capture therapy (BNCT) is an experimental radiation treatment modality used for highly malignant tumor treatments. Prior to irradiation with low energetic neutrons, a 10B compound is located selectively in the tumor cells. The effect of the treatment is based on the high LET radiation released in the 10 B(n,α) 7 Li reaction with thermal neutrons. BNCT has been used experimentally for brain tumor and melanoma treatments. Lately applications of other severe tumor type treatments have been introduced. Results have shown that liver tumors can also be treated by BNCT. At Lawrence Berkeley National Laboratory, various compact neutron generators based on D-D or D-T fusion reactions are being developed. The earlier theoretical studies of the D-D or D-T fusion reaction based neutron generators have shown that the optimal moderator and reflector configuration for brain tumor BNCT can be created. In this work, the applicability of 2.5 MeV neutrons for liver tumor BNCT application was studied. The optimal neutron energy for external liver treatments is not known. Neutron beams of different energies (1eV < E < 100 keV) were simulated and the dose distribution in the liver was calculated with the MCNP simulation code. In order to obtain the optimal neutron energy spectrum with the D-D neutrons, various moderator designs were performed using MCNP simulations. In this article the neutron spectrum and the optimized beam shaping assembly for liver tumor treatments is presented

  15. Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate

    DEFF Research Database (Denmark)

    Stock, Roberto; Brewer, Jonathan R.; Wagner, Kerstin

    2012-01-01

    The toxicity of Loxosceles spider venom has been attributed to a rare enzyme, sphingomyelinase D, which transforms sphingomyelin to ceramide-1-phosphate. The bases of its inflammatory and dermonecrotic activity, however, remain unclear. In this work the effects of ceramide-1-phosphate on model...... membranes were studied both by in situ generation of this lipid using a recombinant sphingomyelinase D from the spider Loxosceles laeta and by pre-mixing it with sphingomyelin and cholesterol. The systems of choice were large unilamellar vesicles for bulk studies (enzyme kinetics, fluorescence spectroscopy...... and dynamic light scattering) and giant unilamellar vesicles for fluorescence microscopy examination using a variety of fluorescent probes. The influence of membrane lateral structure on the kinetics of enzyme activity and the consequences of enzyme activity on the structure of target membranes containing...

  16. The analysis of historical seismograms: an important tool for seismic hazard assessment. Case histories from French and Italian earthquakes

    International Nuclear Information System (INIS)

    Pino, N.A.

    2011-01-01

    Seismic hazard assessment relies on the knowledge of the source characteristics of past earthquakes. Unfortunately, seismic waveform analysis, representing the most powerful tool for the investigation of earthquake source parameters, is only possible for events occurred in the last 100-120 years, i.e., since seismographs with known response function were developed. Nevertheless, during this time significant earthquakes have been recorded by such instruments and today, also thanks to technological progress, these data can be recovered and analysed by means of modern techniques. In this paper, aiming at giving a general sketch of possible analyses and attainable results in historical seismogram studies, I briefly describe the major difficulties in processing the original waveforms and present a review of the results that I obtained from previous seismogram analysis of selected significant historical earthquakes occurred during the first decades of the 20. century, including (A) the December 28, 1908, Messina straits (southern Italy), (B) the June 11, 1909, Lambesc (southern France) - both of which are the strongest ever recorded instrumentally in their respective countries - and (C) the July 13, 1930, Irpinia (southern Italy) events. For these earthquakes, the major achievements are represented by the assessment of the seismic moment (A, B, C), the geometry and kinematics of faulting (B, C), the fault length and an approximate slip distribution (A, C). The source characteristics of the studied events have also been interpreted in the frame of the tectonic environment active in the respective region of interest. In spite of the difficulties inherent to the investigation of old seismic data, these results demonstrate the invaluable and irreplaceable role of historical seismogram analysis in defining the local seismo-genic potential and, ultimately, for assessing the seismic hazard. The retrieved information is crucial in areas where important civil engineering works

  17. Constraining the source location of the 30 May 2015 (Mw 7.9) Bonin deep-focus earthquake using seismogram envelopes of high-frequency P waveforms: Occurrence of deep-focus earthquake at the bottom of a subducting slab

    Science.gov (United States)

    Takemura, Shunsuke; Maeda, Takuto; Furumura, Takashi; Obara, Kazushige

    2016-05-01

    In this study, the source location of the 30 May 2015 (Mw 7.9) deep-focus Bonin earthquake was constrained using P wave seismograms recorded across Japan. We focus on propagation characteristics of high-frequency P wave. Deep-focus intraslab earthquakes typically show spindle-shaped seismogram envelopes with peak delays of several seconds and subsequent long-duration coda waves; however, both the main shock and aftershock of the 2015 Bonin event exhibited pulse-like P wave propagations with high apparent velocities (~12.2 km/s). Such P wave propagation features were reproduced by finite-difference method simulations of seismic wave propagation in the case of slab-bottom source. The pulse-like P wave seismogram envelopes observed from the 2015 Bonin earthquake show that its source was located at the bottom of the Pacific slab at a depth of ~680 km, rather than within its middle or upper regions.

  18. Complete synthetic seismograms based on a spherical self-gravitating Earth model with an atmosphere-ocean-mantle-core structure

    Science.gov (United States)

    Wang, Rongjiang; Heimann, Sebastian; Zhang, Yong; Wang, Hansheng; Dahm, Torsten

    2017-09-01

    A hybrid method is proposed to calculate complete synthetic seismograms based on a spherically symmetric and self-gravitating Earth with a multilayered structure of atmosphere, ocean, mantle, liquid core and solid core. For large wavelengths, a numerical scheme is used to solve the geodynamic boundary-value problem without any approximation on the deformation and gravity coupling. With decreasing wavelength, the gravity effect on the deformation becomes negligible and the analytical propagator scheme can be used. Many useful approaches are used to overcome the numerical problems that may arise in both analytical and numerical schemes. Some of these approaches have been established in the seismological community and the others are developed for the first time. Based on the stable and efficient hybrid algorithm, an all-in-one code QSSP is implemented to cover the complete spectrum of seismological interests. The performance of the code is demonstrated by various tests including the curvature effect on teleseismic body and surface waves, the appearance of multiple reflected, teleseismic core phases, the gravity effect on long period surface waves and free oscillations, the simulation of near-field displacement seismograms with the static offset, the coupling of tsunami and infrasound waves, and free oscillations of the solid Earth, the atmosphere and the ocean. QSSP is open source software that can be used as a stand-alone FORTRAN code or may be applied in combination with a Python toolbox to calculate and handle Green's function databases for efficient coding of source inversion problems.

  19. Reassessment of source parameters for three major earthquakes in the East African rift system from historical seismograms and bulletins

    OpenAIRE

    Ayele, A.; Kulhánek, O.

    2000-01-01

    Source parameters for three majo earthquakes in the East African rift are re-computed from historical seismograms and bulletins. The main shock and the largest foreshock of the August 25, 1906 earthquake sequence in the main Ethiopian rift are re-located on the eastern shoulder of the rift segment.The magnitude of the main shock is estimated to be 6.5 (Mw) from spectral analysis. The December 13, 1910 earthquake in the Rukwa rift (Western Tanzania) indicated a significant strike-slip componen...

  20. TLS for generating multi-LOD of 3D building model

    International Nuclear Information System (INIS)

    Akmalia, R; Setan, H; Majid, Z; Suwardhi, D; Chong, A

    2014-01-01

    The popularity of Terrestrial Laser Scanners (TLS) to capture three dimensional (3D) objects has been used widely for various applications. Development in 3D models has also led people to visualize the environment in 3D. Visualization of objects in a city environment in 3D can be useful for many applications. However, different applications require different kind of 3D models. Since a building is an important object, CityGML has defined a standard for 3D building models at four different levels of detail (LOD). In this research, the advantages of TLS for capturing buildings and the modelling process of the point cloud can be explored. TLS will be used to capture all the building details to generate multi-LOD. This task, in previous works, involves usually the integration of several sensors. However, in this research, point cloud from TLS will be processed to generate the LOD3 model. LOD2 and LOD1 will then be generalized from the resulting LOD3 model. Result from this research is a guiding process to generate the multi-LOD of 3D building starting from LOD3 using TLS. Lastly, the visualization for multi-LOD model will also be shown

  1. TLS for generating multi-LOD of 3D building model

    Science.gov (United States)

    Akmalia, R.; Setan, H.; Majid, Z.; Suwardhi, D.; Chong, A.

    2014-02-01

    The popularity of Terrestrial Laser Scanners (TLS) to capture three dimensional (3D) objects has been used widely for various applications. Development in 3D models has also led people to visualize the environment in 3D. Visualization of objects in a city environment in 3D can be useful for many applications. However, different applications require different kind of 3D models. Since a building is an important object, CityGML has defined a standard for 3D building models at four different levels of detail (LOD). In this research, the advantages of TLS for capturing buildings and the modelling process of the point cloud can be explored. TLS will be used to capture all the building details to generate multi-LOD. This task, in previous works, involves usually the integration of several sensors. However, in this research, point cloud from TLS will be processed to generate the LOD3 model. LOD2 and LOD1 will then be generalized from the resulting LOD3 model. Result from this research is a guiding process to generate the multi-LOD of 3D building starting from LOD3 using TLS. Lastly, the visualization for multi-LOD model will also be shown.

  2. Performance characteristics of a prompt gamma-ray activation analysis (PGAA) system equipped with a new compact D-D neutron generator

    Energy Technology Data Exchange (ETDEWEB)

    Park, Yong Joon; Song, Byung Chul; Im, Hee-Jung [Nuclear Chemistry Research Division, Korea Atomic Energy Research Institute, Dukjin-dong 150-1, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Kim, Jong-Yun [Nuclear Chemistry Research Division, Korea Atomic Energy Research Institute, Dukjin-dong 150-1, Yuseong-gu, Daejeon 305-353 (Korea, Republic of)], E-mail: kjy@kaeri.re.kr

    2009-07-21

    A new prompt gamma-ray activation analysis (PGAA) system equipped with a compact deuterium-deuterium (D-D) neutron generator has been developed for fast detection of explosives and chemical warfare agents. The PGAA system was built based on a fully high-voltage-shielded, axial D-D neutron generator with a radio frequency (RF)-driven ion source. The ionic current of the compact neutron generator was determined as a function of the acceleration voltage at various RF powers. Monoenergetic neutrons (2.45 MeV) with a neutron yield of >1x10{sup 7} n/s were obtained at a deuterium pressure of 8.0 mTorr, an acceleration voltage of 80 kV, and an RF power of 1.1 kW. The performance of the PGAA system was examined by studying the dependence of a prompt gamma-ray count rate on crucial operating parameters.

  3. Mixing in 3D Sparse Multi-Scale Grid Generated Turbulence

    Science.gov (United States)

    Usama, Syed; Kopec, Jacek; Tellez, Jackson; Kwiatkowski, Kamil; Redondo, Jose; Malik, Nadeem

    2017-04-01

    Flat 2D fractal grids are known to alter turbulence characteristics downstream of the grid as compared to the regular grids with the same blockage ratio and the same mass inflow rates [1]. This has excited interest in the turbulence community for possible exploitation for enhanced mixing and related applications. Recently, a new 3D multi-scale grid design has been proposed [2] such that each generation of length scale of turbulence grid elements is held in its own frame, the overall effect is a 3D co-planar arrangement of grid elements. This produces a 'sparse' grid system whereby each generation of grid elements produces a turbulent wake pattern that interacts with the other wake patterns downstream. A critical motivation here is that the effective blockage ratio in the 3D Sparse Grid Turbulence (3DSGT) design is significantly lower than in the flat 2D counterpart - typically the blockage ratio could be reduced from say 20% in 2D down to 4% in the 3DSGT. If this idea can be realized in practice, it could potentially greatly enhance the efficiency of turbulent mixing and transfer processes clearly having many possible applications. Work has begun on the 3DSGT experimentally using Surface Flow Image Velocimetry (SFIV) [3] at the European facility in the Max Planck Institute for Dynamics and Self-Organization located in Gottingen, Germany and also at the Technical University of Catalonia (UPC) in Spain, and numerically using Direct Numerical Simulation (DNS) at King Fahd University of Petroleum & Minerals (KFUPM) in Saudi Arabia and in University of Warsaw in Poland. DNS is the most useful method to compare the experimental results with, and we are studying different types of codes such as Imcompact3d, and OpenFoam. Many variables will eventually be investigated for optimal mixing conditions. For example, the number of scale generations, the spacing between frames, the size ratio of grid elements, inflow conditions, etc. We will report upon the first set of findings

  4. Deep Convolutional Generative Adversarial Network for Procedural 3D Landscape Generation Based on DEM

    DEFF Research Database (Denmark)

    Wulff-Jensen, Andreas; Rant, Niclas Nerup; Møller, Tobias Nordvig

    2018-01-01

    as it has been used to generate game maps in previous productions [3, 4]. The diversity test showed the generated maps had a significantly greater diversity than the Perlin noise maps. Afterwards the heightmaps was converted to 3D maps in Unity3D. The 3D maps’ perceived realism and videogame usability...

  5. Prompt-gamma neutron activation analysis system design. Effects of D-T versus D-D neutron generator source selection

    International Nuclear Information System (INIS)

    Shypailo, R.J.; Ellis, K.J.

    2008-01-01

    Prompt-gamma neutron activation (PGNA) analysis is used for the non-invasive measurement of human body composition. Advancements in portable, compact neutron generator design have made those devices attractive as neutron sources. Two distinct generators are available: D-D with 2.5 MeV and D-T with 14.2 MeV neutrons. To compare the performance of these two units in our present PGNA system, we performed Monte Carlo simulations (MCNP-5; Los Alamos National Laboratory) evaluating the nitrogen reactions produced in tissue-equivalent phantoms and the effects of background interference on the gamma-detectors. Monte Carlo response curves showed increased gamma production per unit dose when using the D-D generator, suggesting that it is the more suitable choice for smaller sized subjects. The increased penetration by higher energy neutrons produced by the D-T generator supports its utility when examining larger, especially obese, subjects. A clinical PGNA analysis design incorporating both neutron generator options may be the best choice for a system required to measure a wide range of subject phenotypes. (author)

  6. High-frequency source radiation during the 2011 Tohoku-Oki earthquake, Japan, inferred from KiK-net strong-motion seismograms

    Science.gov (United States)

    Kumagai, Hiroyuki; Pulido, Nelson; Fukuyama, Eiichi; Aoi, Shin

    2013-01-01

    investigate source processes of the 2011 Tohoku-Oki earthquake, we utilized a source location method using high-frequency (5-10 Hz) seismic amplitudes. In this method, we assumed far-field isotropic radiation of S waves, and conducted a spatial grid search to find the best fitting source locations along the subducted slab in each successive time window. Our application of the method to the Tohoku-Oki earthquake resulted in artifact source locations at shallow depths near the trench caused by limited station coverage and noise effects. We then assumed various source node distributions along the plate, and found that the observed seismograms were most reasonably explained when assuming deep source nodes. This result suggests that the high-frequency seismic waves were radiated at deeper depths during the earthquake, a feature which is consistent with results obtained from teleseismic back-projection and strong-motion source model studies. We identified three high-frequency subevents, and compared them with the moment-rate function estimated from low-frequency seismograms. Our comparison indicated that no significant moment release occurred during the first high-frequency subevent and the largest moment-release pulse occurred almost simultaneously with the second high-frequency subevent. We speculated that the initial slow rupture propagated bilaterally from the hypocenter toward the land and trench. The landward subshear rupture propagation consisted of three successive high-frequency subevents. The trenchward propagation ruptured the strong asperity and released the largest moment near the trench.

  7. Design of analytical instrumentation with D-T sealed neutron generators

    International Nuclear Information System (INIS)

    Qiao Yahua; Wu Jizong; Zheng Weiming; Liu Quanwei; Zhang Min

    2008-01-01

    Analytical instrumentation with D-T sealed neutron generators source activation, The 14 MeV D-T sealed neutron tube with 10 9 n · s -1 neutron yield is used as generator source. The optimal structure of moderator and shield was achieved by MC computing.The instrumentation's configuration is showed. The instrumentation is made up of the SMY-DT50.8-2.1 sealed neutron tube and the high-voltage power supply system, which center is the sealed neutron generators. 6 cm Pb and 20 cm polythene is chosen as moderator, Pb, polythene and 10 cm boron-PE was chosen as shield .The sample box is far the source from 9 cm, the measurement system were made up of HPGe detector and the sample transforming system. After moderator and shield, the thermal neutron fluence rate at the point of sample is 0.93 × 10 6 n · s -1 cm -2 , which is accorded with design demand, and the laboratory and surroundings reaches the safety standard of the dose levels. (authors)

  8. PREP-PWR-1.0: a WIMS-D/4 pre-processor code for the generation of data for PWR fuel assemblies

    International Nuclear Information System (INIS)

    Ball, G.

    1991-06-01

    The PREP-PWR-1.0 computer code is a substantially modified version of the PREWIM code which formed part of the original MARIA System (Report J.E.N. 543). PREP-PWR-1.0 is a comprehensive pre-processor code which generates input data for the WIMS-D/4.1 code (Report PEL 294) for PWR fuel assemblies, with or without control and burnable poison rods. This data is generated at various base and off-base conditions. The overall cross section generation methodology is described, followed by a brief overview of the model. Aspects of the base/off-base calculational scheme are outlined. Additional features of the code are described while the input data format of PREP-PWR-1.0 is listed. The sample problems and suggestions for further improvements to the code are also described. 2 figs., 2 tabs., 12 refs

  9. The Evaluation of Steam Generator Level Measurement Model for OPR1000 Using RETRAN-3D

    International Nuclear Information System (INIS)

    Doo Yong Lee; Soon Joon Hong; Byung Chul Lee; Heok Soon Lim

    2006-01-01

    Steam generator level measurement is important factor for plant transient analyses using best estimate thermal hydraulic computer codes since the value of steam generator level is used for steam generator level control system and plant protection system. Because steam generator is in the saturation condition which includes steam and liquid together and is the place that heat exchange occurs from primary side to secondary side, computer codes are hard to calculate steam generator level realistically without appropriate level measurement model. In this paper, we prepare the steam generator models using RETRAN-3D that include geometry models, full range feedwater control system and five types of steam generator level measurement model. Five types of steam generator level measurement model consist of level measurement model using elevation difference in downcomer, 1D level measurement model using fluid mass, 1D level measurement model using fluid volume, 2D level measurement model using power and fluid mass, and 2D level measurement model using power and fluid volume. And we perform the evaluation of the capability of each steam generator level measurement model by simulating the real plant transient condition, the title is 'Reactor Trip by The Failure of The Deaerator Level Control Card of Ulchin Unit 3'. The comparison results between real plant data and RETRAN-3D analyses for each steam generator level measurement model show that 2D level measurement model using power and fluid mass or fluid volume has more realistic prediction capability compared with other level measurement models. (authors)

  10. Prompt-gamma neutron activation analysis system design: Effects of D-T versus D-D neutron generator source selection

    Science.gov (United States)

    Prompt-gamma neutron activation (PGNA) analysis is used for the non-invasive measurement of human body composition. Advancements in portable, compact neutron generator design have made those devices attractive as neutron sources. Two distinct generators are available: D-D with 2.5 MeV and D-T with...

  11. A High Intensity Multi-Purpose D-D Neutron Generator for Nuclear Engineering Laboratories

    International Nuclear Information System (INIS)

    Ka-Ngo Leung; Jasmina L. Vujic; Edward C. Morse; Per F. Peterson

    2005-01-01

    This NEER project involves the design, construction and testing of a low-cost high intensity D-D neutron generator for teaching nuclear engineering students in a laboratory environment without radioisotopes or a nuclear reactor. The neutron generator was designed, fabricated and tested at Lawrence Berkeley National Laboratory (LBNL)

  12. 3-D electromagnetic modeling for very early time sounding of shallow targets using integral equations

    International Nuclear Information System (INIS)

    Xiong, Z.; Tripp, A.C.

    1994-01-01

    This paper presents an integral equation algorithm for 3D EM modeling at high frequencies for applications in engineering an environmental studies. The integral equation method remains the same for low and high frequencies, but the dominant roles of the displacements currents complicate both numerical treatments and interpretations. With singularity extraction technique they successively extended the application of the Hankel filtering technique to the computation of Hankel integrals occurring in high frequency EM modeling. Time domain results are calculated from frequency domain results via Fourier transforms. While frequency domain data are not obvious for interpretations, time domain data show wave-like pictures that resemble seismograms. Both 1D and 3D numerical results show clearly the layer interfaces

  13. The role of the cytoskeleton in cellular force generation in 2D and 3D environments

    International Nuclear Information System (INIS)

    Kraning-Rush, Casey M; Carey, Shawn P; Califano, Joseph P; Smith, Brooke N; Reinhart-King, Cynthia A

    2011-01-01

    To adhere and migrate, cells generate forces through the cytoskeleton that are transmitted to the surrounding matrix. While cellular force generation has been studied on 2D substrates, less is known about cytoskeletal-mediated traction forces of cells embedded in more in vivo-like 3D matrices. Recent studies have revealed important differences between the cytoskeletal structure, adhesion, and migration of cells in 2D and 3D. Because the cytoskeleton mediates force, we sought to directly compare the role of the cytoskeleton in modulating cell force in 2D and 3D. MDA-MB-231 cells were treated with agents that perturbed actin, microtubules, or myosin, and analyzed for changes in cytoskeletal organization and force generation in both 2D and 3D. To quantify traction stresses in 2D, traction force microscopy was used; in 3D, force was assessed based on single cell-mediated collagen fibril reorganization imaged using confocal reflectance microscopy. Interestingly, even though previous studies have observed differences in cell behaviors like migration in 2D and 3D, our data indicate that forces generated on 2D substrates correlate with forces within 3D matrices. Disruption of actin, myosin or microtubules in either 2D or 3D microenvironments disrupts cell-generated force. These data suggest that despite differences in cytoskeletal organization in 2D and 3D, actin, microtubules and myosin contribute to contractility and matrix reorganization similarly in both microenvironments

  14. Safety-Evaluation Report related to the D2/D3 steam-generator design modification

    International Nuclear Information System (INIS)

    1983-03-01

    This Safety Evaluation Report (SER) related to the D2/D3 steam generator design modification has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The purpose of this SER is to issue the staff's evaluation of the acceptability of the design modification for both installation and full-power operation in the D2/D3 steam generators based on the Design Review Panel Report of January 1983

  15. Seismic Wave Generation and Propagation from Complex 3D Explosion Sources

    Science.gov (United States)

    2014-04-28

    source region to regional and teleseismic distances. We simulated the nonproliferation experiment (NPE) including the effects of surface topography...monitoring, Tectonic Strain Release, Nonproliferation Experiment, Shoal 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES...understanding shear wave generation is that symmetry constraints imposed by 1D and 2D calculations act to suppress shear waves. Imposition of 2D axisymmetry

  16. 3D model of steam generator of nuclear power plant Krsko

    International Nuclear Information System (INIS)

    Ravnikar, I.; Petelin, S.

    1995-01-01

    The Westinghouse Electric Corporation D4 steam generator design was analyzed from a thermal-hydraulic point of view using the 3D PHOENICS computer code. Void fraction, velocity and enthalpy distributions were obtained in the U-tube riser. The boundary conditions of primary side were provided by SMUP 1D code. The calculations were carried out for present operating conditions of nuclear power plant Krsko. (author)

  17. Advanced criteria of seismic zoning and synthetic seismograms

    International Nuclear Information System (INIS)

    Panza, G.F.; Vaccari, F.

    1993-04-01

    A brief revision of the traditional deterministic and probabilistic methods of first order seismic zonation, outlining their limits and possibilities, indicates that they can only lead to a kind of ''post-event'' zonation, which has a limited local validity. The strong influence of laterial heterogeneities and of source properties on the spatial distribution of Peak Ground Acceleration (PGA) and of the Total Energy of ground motion (W), indicates that the traditional methods require a deep revision. The method we have developed and applied to a first-order seismic zoning of the whole Italian territory and to the microzoning of specific objects, being based on the computation of synthetic seismograms, makes it possible and necessary to take source and propagation effects into account, fully utilizing the large amount of geological and geotechnical data, already available. Even though it falls in the domain of deterministic approaches, the method is very suitable for inclusion in the definition of new integrated procedures which combine probabilistic and deterministic approaches and allow us to minimize the present drawbacks which characterise the two methods when they are considered separately. If the seismotectonic regime is well known, a very important practical aspect of our deterministic approach is the immediate capability to direct the rescue intervention of the Civil Defence where the greatest damage is expected, by drawing post-event synthetic isoseismals for the source regions. Detailed modelling of ground motion for realistic two-dimensional media is a low-cost but very powerful tool for the prevention aspects of Civil Defence since it allows the computation of realistic seismic input for important structures based on the definition of a wide set of possible scenarios, which can be immediately used in the design of new seismo-resistant constructions and in the reinforcement of existing structures. (author). 65 refs, 14 figs

  18. Numerical Benchmark of 3D Ground Motion Simulation in the Alpine valley of Grenoble, France.

    Science.gov (United States)

    Tsuno, S.; Chaljub, E.; Cornou, C.; Bard, P.

    2006-12-01

    Thank to the use of sophisticated numerical methods and to the access to increasing computational resources, our predictions of strong ground motion become more and more realistic and need to be carefully compared. We report our effort of benchmarking numerical methods of ground motion simulation in the case of the valley of Grenoble in the French Alps. The Grenoble valley is typical of a moderate seismicity area where strong site effects occur. The benchmark consisted in computing the seismic response of the `Y'-shaped Grenoble valley to (i) two local earthquakes (Mlhandle surface topography, the other half comprises predictions based upon 1D (2 contributions), 2D (4 contributions) and empirical Green's function (EGF) (3 contributions) methods. Maximal frequency analysed ranged between 2.5 Hz for 3D calculations and 40 Hz for EGF predictions. We present a detailed comparison of the different predictions using raw indicators (e.g. peak values of ground velocity and acceleration, Fourier spectra, site over reference spectral ratios, ...) as well as sophisticated misfit criteria based upon previous works [2,3]. We further discuss the variability in estimating the importance of particular effects such as non-linear rheology, or surface topography. References: [1] Thouvenot F. et al., The Belledonne Border Fault: identification of an active seismic strike-slip fault in the western Alps, Geophys. J. Int., 155 (1), p. 174-192, 2003. [2] Anderson J., Quantitative measure of the goodness-of-fit of synthetic seismograms, proceedings of the 13th World Conference on Earthquake Engineering, Vancouver, paper #243, 2004. [3] Kristekova M. et al., Misfit Criteria for Quantitative Comparison of Seismograms, Bull. Seism. Soc. Am., in press, 2006.

  19. Dynamic Frames Based Generation of 3D Scenes and Applications

    Directory of Open Access Journals (Sweden)

    Danijel Radošević

    2015-05-01

    Full Text Available Modern graphic/programming tools like Unity enables the possibility of creating 3D scenes as well as making 3D scene based program applications, including full physical model, motion, sounds, lightning effects etc. This paper deals with the usage of dynamic frames based generator in the automatic generation of 3D scene and related source code. The suggested model enables the possibility to specify features of the 3D scene in a form of textual specification, as well as exporting such features from a 3D tool. This approach enables higher level of code generation flexibility and the reusability of the main code and scene artifacts in a form of textual templates. An example of the generated application is presented and discussed.

  20. Generation of 3D templates of active sites of proteins with rigid prosthetic groups.

    Science.gov (United States)

    Nebel, Jean-Christophe

    2006-05-15

    With the increasing availability of protein structures, the generation of biologically meaningful 3D patterns from the simultaneous alignment of several protein structures is an exciting prospect: active sites could be better understood, protein functions and protein 3D structures could be predicted more accurately. Although patterns can already be generated at the fold and topological levels, no system produces high-resolution 3D patterns including atom and cavity positions. To address this challenge, our research focuses on generating patterns from proteins with rigid prosthetic groups. Since these groups are key elements of protein active sites, the generated 3D patterns are expected to be biologically meaningful. In this paper, we present a new approach which allows the generation of 3D patterns from proteins with rigid prosthetic groups. Using 237 protein chains representing proteins containing porphyrin rings, our method was validated by comparing 3D templates generated from homologues with the 3D structure of the proteins they model. Atom positions were predicted reliably: 93% of them had an accuracy of 1.00 A or less. Moreover, similar results were obtained regarding chemical group and cavity positions. Results also suggested our system could contribute to the validation of 3D protein models. Finally, a 3D template was generated for the active site of human cytochrome P450 CYP17, the 3D structure of which is unknown. Its analysis showed that it is biologically meaningful: our method detected the main patterns of the cytochrome P450 superfamily and the motifs linked to catalytic reactions. The 3D template also suggested the position of a residue, which could be involved in a hydrogen bond with CYP17 substrates and the shape and location of a cavity. Comparisons with independently generated 3D models comforted these hypotheses. Alignment software (Nestor3D) is available at http://www.kingston.ac.uk/~ku33185/Nestor3D.html

  1. The algorithms for calculating synthetic seismograms from a dipole source using the derivatives of Green's function

    Science.gov (United States)

    Pavlov, V. M.

    2017-07-01

    The problem of calculating complete synthetic seismograms from a point dipole with an arbitrary seismic moment tensor in a plane parallel medium composed of homogeneous elastic isotropic layers is considered. It is established that the solutions of the system of ordinary differential equations for the motion-stress vector have a reciprocity property, which allows obtaining a compact formula for the derivative of the motion vector with respect to the source depth. The reciprocity theorem for Green's functions with respect to the interchange of the source and receiver is obtained for a medium with cylindrical boundary. The differentiation of Green's functions with respect to the coordinates of the source leads to the same calculation formulas as the algorithm developed in the previous work (Pavlov, 2013). A new algorithm appears when the derivatives with respect to the horizontal coordinates of the source is replaced by the derivatives with respect to the horizontal coordinates of the receiver (with the minus sign). This algorithm is more transparent, compact, and economic than the previous one. It requires calculating the wavenumbers associated with Bessel function's roots of order 0 and order 1, whereas the previous algorithm additionally requires the second order roots.

  2. Wetting effect on optical sum frequency generation (SFG) spectra of D-glucose, D-fructose, and sucrose

    Science.gov (United States)

    Hieu, Hoang Chi; Li, Hongyan; Miyauchi, Yoshihiro; Mizutani, Goro; Fujita, Naoko; Nakamura, Yasunori

    2015-03-01

    We report a sum frequency generation (SFG) spectroscopy study of D-glucose, D-fructose and sucrose in the Csbnd H stretching vibration regime. Wetting effect on the SFG spectra was investigated. The SFG spectrum of D-glucose changed from that of α-D-glucose into those of α-D-glucose monohydrate by wetting. The SFG spectra showed evidence of a small change of β-D-fructopyranose into other anomers by wetting. SFG spectra of sucrose did not change by wetting. Assignments of the vibrational peaks in the SFG spectra of the three sugars in the dry and wet states were performed in the Csbnd H stretching vibration region near 3000 cm-1.

  3. Distributed Generation Market Demand Model (dGen): Documentation

    Energy Technology Data Exchange (ETDEWEB)

    Sigrin, Benjamin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gleason, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Preus, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Baring-Gould, Ian [National Renewable Energy Lab. (NREL), Golden, CO (United States); Margolis, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-02-01

    The Distributed Generation Market Demand model (dGen) is a geospatially rich, bottom-up, market-penetration model that simulates the potential adoption of distributed energy resources (DERs) for residential, commercial, and industrial entities in the continental United States through 2050. The National Renewable Energy Laboratory (NREL) developed dGen to analyze the key factors that will affect future market demand for distributed solar, wind, storage, and other DER technologies in the United States. The new model builds off, extends, and replaces NREL's SolarDS model (Denholm et al. 2009a), which simulates the market penetration of distributed PV only. Unlike the SolarDS model, dGen can model various DER technologies under one platform--it currently can simulate the adoption of distributed solar (the dSolar module) and distributed wind (the dWind module) and link with the ReEDS capacity expansion model (Appendix C). The underlying algorithms and datasets in dGen, which improve the representation of customer decision making as well as the spatial resolution of analyses (Figure ES-1), also are improvements over SolarDS.

  4. Modeling Poroelastic Wave Propagation in a Real 2-D Complex Geological Structure Obtained via Self-Organizing Maps

    Science.gov (United States)

    Itzá Balam, Reymundo; Iturrarán-Viveros, Ursula; Parra, Jorge O.

    2018-03-01

    Two main stages of seismic modeling are geological model building and numerical computation of seismic response for the model. The quality of the computed seismic response is partly related to the type of model that is built. Therefore, the model building approaches become as important as seismic forward numerical methods. For this purpose, three petrophysical facies (sands, shales and limestones) are extracted from reflection seismic data and some seismic attributes via the clustering method called Self-Organizing Maps (SOM), which, in this context, serves as a geological model building tool. This model with all its properties is the input to the Optimal Implicit Staggered Finite Difference (OISFD) algorithm to create synthetic seismograms for poroelastic, poroacoustic and elastic media. The results show a good agreement between observed and 2-D synthetic seismograms. This demonstrates that the SOM classification method enables us to extract facies from seismic data and allows us to integrate the lithology at the borehole scale with the 2-D seismic data.

  5. Syntheses, crystal structures and luminescent properties of two new 1D d 1 coordination polymers constructed from 2,2'-bibenzimidazole and 1,4-benzenedicarboxylate

    International Nuclear Information System (INIS)

    Wen Lili; Li Yizhi; Dang Dongbin; Tian Zhengfang; Ni Zhaoping; Meng Qingjin

    2005-01-01

    Two novel interesting d 1 metal coordination polymers, [Zn(H 2 bibzim)(BDC)] n (1) and [Cd(H 2 bibzim)(BDC)] n (2) [H 2 bibzim=2,2'-bibenzimidazole, BDC=1,4-benzenedicarboxylate] have been synthesized under solvothermal conditions and structurally characterized. Both 1 and 2 are constructed from infinite neutral zigzag-like one-dimensional (1D) chains. The π-π interactions and interchain hydrogen-bonding interactions further extend the 1D arrangement to generate a 3D supramolecular architecture for 1 and 2. Both complexes have high thermal stability and display strong blue fluorescent emissions in the solid state upon photo-excitation at 365 nm at room temperature. They are the first two examples that 2,2'-bibenzimidazole has been introduced into the d 1 coordination polymeric framework

  6. Experimental subcritical facility driven by D-D/D-T neutron generator at BARC, India

    Energy Technology Data Exchange (ETDEWEB)

    Sinha, Amar, E-mail: image@barc.gov.in; Roy, Tushar; Kashyap, Yogesh; Ray, Nirmal; Shukla, Mayank; Patel, Tarun; Bajpai, Shefali; Sarkar, P.S.; Bishnoi, Saroj

    2015-05-01

    Highlights: •Experimental subcritical facility BRAHMMA coupled to D-D/D-T neutron generator. •Preliminary results of PNS experiments reported. •Feynman-alpha noise measurements explored with continuous source. -- Abstract: The paper presents design of an experimental subcritical assembly driven by D-D/D-T neutron and preliminary experimental measurements. The system has been developed for investigating the static and dynamic neutronic properties of accelerator driven sub-critical systems. This system is modular in design and it is first in the series of subcritical assemblies being designed. The subcritical core consists of natural uranium fuel with high density polyethylene as moderator and beryllium oxide as reflector. The fuel is embedded in high density polyethylene moderator matrix. Estimated k{sub eff} of the system is ∼0.89. One of the unique features of subcritical core is the use of Beryllium oxide (BeO) as reflector and HDPE as moderator making the assembly a compact modular system. The subcritical core is coupled to Purnima Neutron Generator which works in D-D and D-T mode with both DC and pulsed operation. It has facility for online source strength monitoring using neutron tagging and programmable source modulation. Preliminary experiments have been carried out for spatial flux measurement and reactivity estimation using pulsed neutron source (PNS) techniques with D-D neutrons. Further experiments are being planned to measure the reactivity and other kinetic parameters using noise methods. This facility would also be used for carrying out studies on effect of source importance and measurement of source multiplication factor k{sub s} and external neutron source efficiency φ{sup ∗} in great details. Experiments with D-T neutrons are also underway.

  7. Minimal unitary representation of D(2,1;λ) and its SU(2) deformations and d=1, N=4 superconformal models

    International Nuclear Information System (INIS)

    Govil, Karan; Gunaydin, Murat

    2013-01-01

    Quantization of the geometric quasiconformal realizations of noncompact groups and supergroups leads directly to their minimal unitary representations (minreps). Using quasiconformal methods massless unitary supermultiplets of superconformal groups SU(2,2|N) and OSp(8 ⁎ |2n) in four and six dimensions were constructed as minreps and their U(1) and SU(2) deformations, respectively. In this paper we extend these results to SU(2) deformations of the minrep of N=4 superconformal algebra D(2,1;λ) in one dimension. We find that SU(2) deformations can be achieved using n pair of bosons and m pairs of fermions simultaneously. The generators of deformed minimal representations of D(2,1;λ) commute with the generators of a dual superalgebra OSp(2n ⁎ |2m) realized in terms of these bosons and fermions. We show that there exists a precise mapping between symmetry generators of N=4 superconformal models in harmonic superspace studied recently and minimal unitary supermultiplets of D(2,1;λ) deformed by a pair of bosons. This can be understood as a particular case of a general mapping between the spectra of quantum mechanical quaternionic Kähler sigma models with eight super symmetries and minreps of their isometry groups that descends from the precise mapping established between the 4d, N=2 sigma models coupled to supergravity and minreps of their isometry groups.

  8. On QCD Q2-evolution of deuteron structure function F2D(xD, Q2) for xD>1

    International Nuclear Information System (INIS)

    Sidorov, A.V.; Tokarev, M.V.

    1995-01-01

    The deep-inelastic deuteron structure function (SF) F 2 D (x D ,Q 2 ) in the covariant approach in light-cone variables is considered. The x D and Q 2 -dependences of SF are calculated. The QCD analysis of generated data both for non-cumulative x D D >1 ranges was performed. It was shown that Q 2 -evolution of SF is valid for ranges 0.275 D D D -dependence of SF for the ranges is essentially different. 23 refs., 2 figs., 1 tab

  9. A search for first generation scalar leptoquarks at √s = 1.8 TeV with the D0 detector

    International Nuclear Information System (INIS)

    Norman, D.M.

    1993-01-01

    A search for first generation scalar leptoquarks was done at the DO detector at Fermi National Accelerator Laboratory from 15 pb-1 of data taken during the 1992--1993 colder run. At Fermilab's p bar p collider with a center-of-mass energy of 1.8 TeV, leptoquarks are produced mostly by the strong force in pairs. Leptoquarks carry fractional charge, color, and also lepton and baryon quantum numbers. First generation leptoquarks couple exclusively to the electron, electron neutrino, and the u and d quarks; such a leptoquark would decay into, for example, an electron plus a quark. Signatures for leptoquarks at p bar p colliders that have been investigated at DO are two electrons plus two jets and one electron plus missing energy (from an electron neutrino) plus two jets

  10. Medium generated gap in gravity and a 3D gauge theory

    Science.gov (United States)

    Gabadadze, Gregory; Older, Daniel

    2018-05-01

    It is well known that a physical medium that sets a Lorentz frame generates a Lorentz-breaking gap for a graviton. We examine such generated "mass" terms in the presence of a fluid medium whose ground state spontaneously breaks spatial translation invariance in d =D +1 spacetime dimensions, and for a solid in D =2 spatial dimensions. By requiring energy positivity and subluminal propagation, certain constraints are placed on the equation of state of the medium. In the case of D =2 spatial dimensions, classical gravity can be recast as a Chern-Simons gauge theory, and motivated by this we recast the massive theory of gravity in AdS3 as a massive Chern-Simons gauge theory with an unusual mass term. We find that in the flat space limit the Chern-Simons theory has a novel gauge invariance that mixes the kinetic and mass terms, and enables the massive theory with a noncompact internal group to be free of ghosts and tachyons.

  11. Nitrogen Detection in Bulk Samples Using a D-D Reaction-Based Portable Neutron Generator

    Directory of Open Access Journals (Sweden)

    A. A. Naqvi

    2013-01-01

    Full Text Available Nitrogen concentration was measured via 2.52 MeV nitrogen gamma ray from melamine, caffeine, urea, and disperse orange bulk samples using a newly designed D-D portable neutron generator-based prompt gamma ray setup. Inspite of low flux of thermal neutrons produced by D-D reaction-based portable neutron generator and interference of 2.52 MeV gamma rays from nitrogen in bulk samples with 2.50 MeV gamma ray from bismuth in BGO detector material, an excellent agreement between the experimental and calculated yields of nitrogen gamma rays indicates satisfactory performance of the setup for detection of nitrogen in bulk samples.

  12. A 3D Photothermal Structure toward Improved Energy Efficiency in Solar Steam Generation

    KAUST Repository

    Shi, Yusuf

    2018-04-18

    Summary The energy efficiency in solar steam generation by 2D photothermal materials has approached its limit. In this work, we fabricated 3D cylindrical cup-shaped structures of mixed metal oxide as solar evaporator, and the 3D structure led to a high energy efficiency close to 100% under one-sun illumination due to the capability of the cup wall to recover the diffuse reflectance and thermal radiation heat loss from the 2D cup bottom. Additional heat was gained from the ambient air when the 3D structure was exposed under one-sun illumination, leading to an extremely high steam generation rate of 2.04 kg m−2 h−1. The 3D structure has a high thermal stability and shows great promise in practical applications including domestic wastewater volume reduction and seawater desalination. The results of this work inspire further research efforts to use 3D photothermal structures to break through the energy efficiency limit of 2D photothermal materials.

  13. High Intensity, Pulsed, D-D Neutron Generator

    International Nuclear Information System (INIS)

    Williams, D.L.; Vainionpaa, J.H.; Jones, G.; Piestrup, M.A.; Gary, C.K.; Harris, J.L.; Fuller, M.J.; Cremer, J.T.; Ludewigt, Bernhard A.; Kwan, J.W.; Reijonen, J.; Leung, K.-N.; Gough, R.A.

    2008-01-01

    Single ion-beam RF-plasma neutron generators are presented as a laboratory source of intense neutrons. The continuous and pulsed operations of such a neutron generator using the deuterium-deuterium fusion reaction are reported. The neutron beam can be pulsed by switching the RF plasma and/or a gate electrode. These generators are actively vacuum pumped so that a continuous supply of deuterium gas is present for the production of ions and neutrons. This contributes to the generator's long life. These single-beam generators are capable of producing up to 1E10 n/s. Previously, Adelphi and LBNL have demonstrated these generators applications in fast neutron radiography, Prompt Gamma Neutron Activation Analysis (PGNAA) and Neutron Activation Analysis (NAA). Together with an inexpensive compact moderator, these high-output neutron generators extend useful applications to home laboratory operations.

  14. On D=2 (1/3,1/3) supersymmetric theories 2

    International Nuclear Information System (INIS)

    Saidi, E.H.; Zerouaoui, J.; Sedra, M.B.

    1994-06-01

    Denoting by D=2 (1/3,1/3) superalgebra; the off critical symmetry of the Φ 5/7,5/7 perturbation of the C=6/7 conformal theory, we build a new superspace solution of the (1/3,1/3) - subalgebra generated by spin ±1/3 charge operators extending the usual (1/2,1/2) supersymmetry generated by spin ±1/2 charges. This solution is based on the use of two Grassmann variables instead of one parafermionic variable θ ±1/3 satisfying the cubic nilpotency condition (θ ±1/3 ) 3 =0. Known results on the C=6/7 tricritical Potts model are recovered as special features. A relation with N=2 Landau-Ginzburg models is also discussed. (author). 17 refs, 1 tab

  15. Automatic 3d Building Model Generations with Airborne LiDAR Data

    Science.gov (United States)

    Yastikli, N.; Cetin, Z.

    2017-11-01

    LiDAR systems become more and more popular because of the potential use for obtaining the point clouds of vegetation and man-made objects on the earth surface in an accurate and quick way. Nowadays, these airborne systems have been frequently used in wide range of applications such as DEM/DSM generation, topographic mapping, object extraction, vegetation mapping, 3 dimensional (3D) modelling and simulation, change detection, engineering works, revision of maps, coastal management and bathymetry. The 3D building model generation is the one of the most prominent applications of LiDAR system, which has the major importance for urban planning, illegal construction monitoring, 3D city modelling, environmental simulation, tourism, security, telecommunication and mobile navigation etc. The manual or semi-automatic 3D building model generation is costly and very time-consuming process for these applications. Thus, an approach for automatic 3D building model generation is needed in a simple and quick way for many studies which includes building modelling. In this study, automatic 3D building models generation is aimed with airborne LiDAR data. An approach is proposed for automatic 3D building models generation including the automatic point based classification of raw LiDAR point cloud. The proposed point based classification includes the hierarchical rules, for the automatic production of 3D building models. The detailed analyses for the parameters which used in hierarchical rules have been performed to improve classification results using different test areas identified in the study area. The proposed approach have been tested in the study area which has partly open areas, forest areas and many types of the buildings, in Zekeriyakoy, Istanbul using the TerraScan module of TerraSolid. The 3D building model was generated automatically using the results of the automatic point based classification. The obtained results of this research on study area verified that automatic 3D

  16. AUTOMATIC 3D BUILDING MODEL GENERATIONS WITH AIRBORNE LiDAR DATA

    Directory of Open Access Journals (Sweden)

    N. Yastikli

    2017-11-01

    Full Text Available LiDAR systems become more and more popular because of the potential use for obtaining the point clouds of vegetation and man-made objects on the earth surface in an accurate and quick way. Nowadays, these airborne systems have been frequently used in wide range of applications such as DEM/DSM generation, topographic mapping, object extraction, vegetation mapping, 3 dimensional (3D modelling and simulation, change detection, engineering works, revision of maps, coastal management and bathymetry. The 3D building model generation is the one of the most prominent applications of LiDAR system, which has the major importance for urban planning, illegal construction monitoring, 3D city modelling, environmental simulation, tourism, security, telecommunication and mobile navigation etc. The manual or semi-automatic 3D building model generation is costly and very time-consuming process for these applications. Thus, an approach for automatic 3D building model generation is needed in a simple and quick way for many studies which includes building modelling. In this study, automatic 3D building models generation is aimed with airborne LiDAR data. An approach is proposed for automatic 3D building models generation including the automatic point based classification of raw LiDAR point cloud. The proposed point based classification includes the hierarchical rules, for the automatic production of 3D building models. The detailed analyses for the parameters which used in hierarchical rules have been performed to improve classification results using different test areas identified in the study area. The proposed approach have been tested in the study area which has partly open areas, forest areas and many types of the buildings, in Zekeriyakoy, Istanbul using the TerraScan module of TerraSolid. The 3D building model was generated automatically using the results of the automatic point based classification. The obtained results of this research on study area verified

  17. The SCEC Broadband Platform: A Collaborative Open-Source Software Package for Strong Ground Motion Simulation and Validation

    Science.gov (United States)

    Silva, F.; Maechling, P. J.; Goulet, C. A.; Somerville, P.; Jordan, T. H.

    2014-12-01

    The Southern California Earthquake Center (SCEC) Broadband Platform is a collaborative software development project involving geoscientists, earthquake engineers, graduate students, and the SCEC Community Modeling Environment. The SCEC Broadband Platform (BBP) is open-source scientific software that can generate broadband (0-100Hz) ground motions for earthquakes, integrating complex scientific modules that implement rupture generation, low and high-frequency seismogram synthesis, non-linear site effects calculation, and visualization into a software system that supports easy on-demand computation of seismograms. The Broadband Platform operates in two primary modes: validation simulations and scenario simulations. In validation mode, the Platform runs earthquake rupture and wave propagation modeling software to calculate seismograms for a well-observed historical earthquake. Then, the BBP calculates a number of goodness of fit measurements that quantify how well the model-based broadband seismograms match the observed seismograms for a certain event. Based on these results, the Platform can be used to tune and validate different numerical modeling techniques. In scenario mode, the Broadband Platform can run simulations for hypothetical (scenario) earthquakes. In this mode, users input an earthquake description, a list of station names and locations, and a 1D velocity model for their region of interest, and the Broadband Platform software then calculates ground motions for the specified stations. Working in close collaboration with scientists and research engineers, the SCEC software development group continues to add new capabilities to the Broadband Platform and to release new versions as open-source scientific software distributions that can be compiled and run on many Linux computer systems. Our latest release includes 5 simulation methods, 7 simulation regions covering California, Japan, and Eastern North America, the ability to compare simulation results

  18. Verification of 3-D generation code package for neutronic calculations of WWERs

    International Nuclear Information System (INIS)

    Sidorenko, V.D.; Aleshin, S.S.; Bolobov, P.A.; Bolshagin, S.N.; Lazarenko, A.P.; Markov, A.V.; Morozov, V.V.; Syslov, A.A.; Tsvetkov, V.M.

    2000-01-01

    Materials on verification of the 3 -d generation code package for WWERs neutronic calculations are presented. The package includes: - spectral code TVS-M; - 2-D fine mesh diffusion code PERMAK-A for 4- or 6-group calculation of WWER core burnup; - 3-D coarse mesh diffusion code BIPR-7A for 2-group calculations of quasi-stationary WWERs regimes. The materials include both TVS-M verification data and verification data on PERMAK-A and BIPR-7A codes using constant libraries generated with TVS-M. All materials are related to the fuel without Gd. TVS-M verification materials include results of comparison both with benchmark calculations obtained by other codes and with experiments carried out at ZR-6 critical facility. PERMAK-A verification materials contain results of comparison with TVS-M calculations and with ZR-6 experiments. BIPR-7A materials include comparison with operation data for Dukovany-2 and Loviisa-1 NPPs (WWER-440) and for Balakovo NPP Unit 4 (WWER-1000). The verification materials demonstrate rather good accuracy of calculations obtained with the use of code package of the 3 -d generation. (Authors)

  19. Joint sparse learning for 3-D facial expression generation.

    Science.gov (United States)

    Song, Mingli; Tao, Dacheng; Sun, Shengpeng; Chen, Chun; Bu, Jiajun

    2013-08-01

    3-D facial expression generation, including synthesis and retargeting, has received intensive attentions in recent years, because it is important to produce realistic 3-D faces with specific expressions in modern film production and computer games. In this paper, we present joint sparse learning (JSL) to learn mapping functions and their respective inverses to model the relationship between the high-dimensional 3-D faces (of different expressions and identities) and their corresponding low-dimensional representations. Based on JSL, we can effectively and efficiently generate various expressions of a 3-D face by either synthesizing or retargeting. Furthermore, JSL is able to restore 3-D faces with holes by learning a mapping function between incomplete and intact data. Experimental results on a wide range of 3-D faces demonstrate the effectiveness of the proposed approach by comparing with representative ones in terms of quality, time cost, and robustness.

  20. D.C.-arc plasma generator for nonequilibrium plasmachemical processes

    International Nuclear Information System (INIS)

    Kvaltin, J.

    1990-06-01

    The analysis is made of the conditions for generation of nonequilibrium plasma in a plasmachemical reactor, and the design is described of a d.c. arc plasma generator based on the integral criterion. Results of measuring potentials on the plasma column of this generator are presented. (author)

  1. Analysis of the neutron generation from a D-Li neutron source

    International Nuclear Information System (INIS)

    Gomes, I.

    1994-02-01

    The study of the neutron generation from the D-Li reaction is an important issue to define the optimum combination of the intervening parameters during the design phase of a D-Li neutron source irradiation facility. The major players in defining the neutron yield from the D-Li reaction are the deuteron incident energy and the beam current, provided that the lithium target is thick enough to stop all incident deuterons. The incident deuteron energy also plays a role on the angular distribution of the generated neutrons, on the energy distribution of the generated neutrons, and on the maximum possible energy of the neutrons. The D-Li reaction produces neutrons with energies ranging from eV's to several MeV's. The angular distribution of these neutrons is dependent on the energy of both, incident deuterons and generated neutrons. The deuterons lose energy interacting with the lithium target material in such a way that the energy of the deuterons inside the lithium target varies from the incident deuteron energy to essentially zero. The first part of this study focuses in analyzing the neutron generation rate from the D-Li reaction as a function of the intervening parameters, in defining the source term, in terms of the energy and angular distributions of the generated neutrons, and finally in providing some insights of the impact of varying input parameters on the generation rate and correlated distributions. In the second part an analytical description of the Monte Carlo sampling procedure of the neutron from the D-Li reaction is provided with the aim at further Monte Carlo transport of the D-Li neutrons

  2. The Feasibility of 3d Point Cloud Generation from Smartphones

    Science.gov (United States)

    Alsubaie, N.; El-Sheimy, N.

    2016-06-01

    This paper proposes a new technique for increasing the accuracy of direct geo-referenced image-based 3D point cloud generated from low-cost sensors in smartphones. The smartphone's motion sensors are used to directly acquire the Exterior Orientation Parameters (EOPs) of the captured images. These EOPs, along with the Interior Orientation Parameters (IOPs) of the camera/ phone, are used to reconstruct the image-based 3D point cloud. However, because smartphone motion sensors suffer from poor GPS accuracy, accumulated drift and high signal noise, inaccurate 3D mapping solutions often result. Therefore, horizontal and vertical linear features, visible in each image, are extracted and used as constraints in the bundle adjustment procedure. These constraints correct the relative position and orientation of the 3D mapping solution. Once the enhanced EOPs are estimated, the semi-global matching algorithm (SGM) is used to generate the image-based dense 3D point cloud. Statistical analysis and assessment are implemented herein, in order to demonstrate the feasibility of 3D point cloud generation from the consumer-grade sensors in smartphones.

  3. Deep Convolutional Generative Adversarial Network for Procedural 3D Landscape Generation Based on DEM

    OpenAIRE

    Wulff-Jensen, Andreas; Rant, Niclas Nerup; Møller, Tobias Nordvig; Billeskov, Jonas Aksel

    2018-01-01

    This paper proposes a novel framework for improving procedural generation of 3D landscapes using machine learning. We utilized a Deep Convolutional Generative Adversarial Network (DC-GAN) to generate heightmaps. The network was trained on a dataset consisting of Digital Elevation Maps (DEM) of the alps. During map generation, the batch size and learning rate were optimized for the most efficient and satisfying map production. The diversity of the final output was tested against Perlin noise u...

  4. MODELING THE RADIATION SHIELDING OF BORON NEUTRON CAPTURE THERAPY BASED ON 2.4 MEV D-D NEUTRON GENERATOR FACILITY

    Directory of Open Access Journals (Sweden)

    Muhammad Mu’Alim

    2018-01-01

    PEMODELAN PERISAI RADIASI PADA FASILITAS BORON NEUTRON CAPTURE THERAPY BERBASIS GENERATOR NEUTRON D-D 2,4 MeV. Telah dimodelkan perisai radiasi pada fasilitas Boron Neutron Capture Therapy (BNCT berbasis reaksi D-D pada Neutron Generator 2,4 MeV dengan Beam Shaping Assembly (BSA yang telah didesain sebelumnya. Pemodelan ini dilakukan untuk memperoleh suatu desain perisai radiasi untuk fasilitas BNCT berbasis generator neutron 2,4 MeV. Pemodelan dilakukan dengan cara memvariasikan bahan dan ketebalan perisasi radiasi. Bahan yang dipilih adalah beton barit, parafin, polietilen terborasi dan timbal. Perhitungan dilakukan menggunakan program MCNPX dengan tally F4 untuk menentukan laju dosis yang keluar dari perisai radiasi. Desain periasi radiasi dinyatakan optimal jika radiasi yang dihasilkan diluar perisai radiasi tidak melebihi Nilai Batas Dosis (NBD yang telah ditentukan oleh BAPETEN. Hasilnya, diperoleh suatu desain perisai radiasi menggunakan lapisan utama beton barit setebal 100 cm yang mengelilingi ruangan 100 cm x 100 cm x 166,4 cm dan polietilen terborasi 40 cm yang mengelilingi bahan beton barit. Kemudian ditambahkan beton barit 10 cm dan polietilen terborasi 10 cm untuk mengurangi radiasi primer yang lurus dari BSA setelah keluar dari lapisan utama. Laju dosis terbesar adalah 4,58 μSv·jam-1 pada sel 227 dan laju dosis rata-rata yang dihasilkan adalah sebesar 0,65 µSv·jam-1. Nilai laju dosis tersebut masih dibawah ambang batas NBD yang diperbolehkan oleh BAPETEN untuk pekerja radiasi. Kata kunci: Perisai radiasi, tally, laju dosis radiasi, BSA, BNCT

  5. Resolvin D1 and D2 Reverse Lipopolysaccharide-Induced Depression-Like Behaviors Through the mTORC1 Signaling Pathway.

    Science.gov (United States)

    Deyama, Satoshi; Ishikawa, Yuka; Yoshikawa, Kotomi; Shimoda, Kento; Ide, Soichiro; Satoh, Masamichi; Minami, Masabumi

    2017-07-01

    Resolvin D1 and D2 are bioactive lipid mediators that are generated from docosahexaenoic acid. Although recent preclinical studies suggest that these compounds have antidepressant effects, their mechanisms of action remain unclear. We investigated mechanisms underlying the antidepressant effects of resolvin D1 and resolvin D2 in lipopolysaccharide (0.8 mg/kg, i.p.)-induced depression model mice using a tail suspension test. I.c.v. infusion of resolvin D1 (10 ng) and resolvin D2 (10 ng) produced antidepressant effects; these effects were significantly blocked by a resolvin D1 receptor antagonist WRW4 (10 µg, i.c.v.) and a resolvin D2 receptor antagonist O-1918 (10 µg, i.c.v.), respectively. The mammalian target of rapamycin complex 1 inhibitor rapamycin (10 mg/kg, i.p.) and a mitogen-activated protein kinase kinase inhibitor U0126 (5 µg, i.c.v.) significantly blocked the antidepressant effects of resolvin D1 and resolvin D2. An AMPA receptor antagonist NBQX (10 mg/kg, i.p.) and a phosphoinositide 3-kinase inhibitor LY294002 (3 µg, i.c.v.) blocked the antidepressant effects of resolvin D1 significantly, but not of resolvin D2. Bilateral infusions of resolvin D1 (0.3 ng/side) or resolvin D2 (0.3 ng/side) into the medial prefrontal cortex or dentate gyrus of the hippocampus produced antidepressant effects. These findings demonstrate that resolvin D1 and resolvin D2 produce antidepressant effects via the mammalian target of rapamycin complex 1 signaling pathway, and that the medial prefrontal cortex and dentate gyrus are important brain regions for these antidepressant effects. These compounds and their receptors may be promising targets for the development of novel rapid-acting antidepressants, like ketamine and scopolamine. © The Author 2017. Published by Oxford University Press on behalf of CINP.

  6. 3D Model Generation From the Engineering Drawing

    Science.gov (United States)

    Vaský, Jozef; Eliáš, Michal; Bezák, Pavol; Červeňanská, Zuzana; Izakovič, Ladislav

    2010-01-01

    The contribution deals with the transformation of engineering drawings in a paper form into a 3D computer representation. A 3D computer model can be further processed in CAD/CAM system, it can be modified, archived, and a technical drawing can be then generated from it as well. The transformation process from paper form to the data one is a complex and difficult one, particularly owing to the different types of drawings, forms of displayed objects and encountered errors and deviations from technical standards. The algorithm for 3D model generating from an orthogonal vector input representing a simplified technical drawing of the rotational part is described in this contribution. The algorithm was experimentally implemented as ObjectARX application in the AutoCAD system and the test sample as the representation of the rotational part was used for verificaton.

  7. Model of the seismic velocity distribution in the upper lithosphere of the Vrancea seismogenic zone and within the adjacent areas

    International Nuclear Information System (INIS)

    Raileanu, Victor; Bala, Andrei

    2002-01-01

    The task of this project is to perform a detailed seismic velocity model of the P waves in the crust and upper mantle crossed by the VRANCEA 2001 seismic line and to interpret it in structural terms. The velocity model aims to contribute to a new geodynamical model of the Eastern Carpathians evolution and to a better understanding of the causes of the Vrancea earthquakes. It is performed in cooperation with the University of Karlsruhe, Germany, and University of Bucharest. The Project will be completed in 5 working stages. Vrancea 2001 is the name of the seismic line recorded with about 780 seismic instruments deployed over more then 600 km length from eastern part of Romania (east Tulcea) through Vrancea area to Aiud and south Oradea. 10 big shots with charges from 300 kg to 1500 kg dynamite were detonated along seismic line. Field data quality is from good to very good and it provides information down to the upper mantle levels. Processing of data has been performed in the first stage of present project and it consisted in merging of all individual field records in seismograms for each shotpoint. Almost 800 individual records for each out of the 10 shots were merged in 10 seismograms with about 800 channels. A seismogram of shot point S (25 km NE of Ramnicu Sarat) is given. It is visible a high energy generated by shotpoint S. Pn wave can be traced until the western end of seismic line, about 25 km from source. In the second stage of project an interpretation of seismic data is achieved for the first 5 seismograms from the eastern half of seismic line, from Tulcea to Ramnicu Sarat. It is used a forward modeling procedure. 5 unidimensional (1D) velocity-depth function models are obtained. P wave velocity-depth function models for shotpoints from O to T are presented. Velocity-depth information is extended down to 40 km for shot R and 80 km for shot S. It should noticed the unusually high velocities at the shallow levels for Dobrogea area (O and P shots) and the

  8. Development of High Intensity D-T fusion NEutron Generator (HINEG)

    Science.gov (United States)

    Wu, Yican; Liu, Chao; Song, Gang; Wang, Yongfeng; Li, Taosheng; Jiang, Jieqiong; Song, Yong; Ji, Xiang

    2017-09-01

    A high intensity D-T fusion neutron generator (HINEG) is keenly needed for the research and development (R&D) of nuclear technology and safety of the advanced nuclear energy system, especially for the radiation protection and shielding. The R&D of HINEG includes two phases: HINEG-I and HINEG-II. HINEG-I is designed to have both the steady beam and pulsed beam. The neutron yield of the steady beam is up to 1012 n/s. The width of pulse neutron beam is less than 1.5 ns. HINEG-I is used for the basic neutronics study, such as measurement of nuclear data, validation of neutronics methods and software, validation of radiation protection and so on. HINEG-II aims to generate a high neutron yield of 1013 n/s neutrons by adopting high speed rotating tritium target system integrated with jet/spray array enhanced cooling techniques, and can further upgrade to obtain neutron yield of 1014 1015n/s by using of accelerators-array in a later stage. HINEG-II can be used for fundamentals research of nuclear technology including mechanism of materials radiation damage and neutronics performance of components, radiation shielding as well as other nuclear technology applications.

  9. New coordination polymers from 1D chain, 2D layer to 3D framework constructed from 1,2-phenylenediacetic acid and 1,3-bis(4-pyridyl)propane flexible ligands

    Science.gov (United States)

    Xin, Ling-Yun; Liu, Guang-Zhen; Wang, Li-Ya

    2011-06-01

    The hydrothermal reactions of Cd, Zn, or Cu(II) acetate salts with H 2PHDA and BPP flexible ligands afford three new coordination polymers, including [Cd(PHDA)(BPP)(H 2O)] n(1), [Zn(PHDA)(BPP)] n(2), and [Cu 2(PHDA) 2(BPP)] n(3) (H 2PHDA=1,2-phenylenediacetic acid, BPP=1,3-bis(4-pyridyl)propane). The single-crystal X-ray diffractions reveal that all three complexes feature various metal carboxylate subunits extended further by the BPP ligands to form a diverse range of structures, displaying a remarked structural sensitivity to metal(II) cation. Complex 1 containing PHDA-bridged binuclear cadmium generates 1D double-stranded chain, complex 2 results in 2D→2D interpenetrated (4,4) grids, and complex 3 displays a 3D self-penetrated framework with 4 86 68 rob topology. In addition, fluorescent analyses show that both 1 and 2 exhibit intense blue-violet photoluminescence in the solid state.

  10. Fast DRR generation for 2D to 3D registration on GPUs

    Energy Technology Data Exchange (ETDEWEB)

    Tornai, Gabor Janos; Cserey, Gyoergy [Faculty of Information Technology, Pazmany Peter Catholic University, Prater u. 50/a, H-1083, Budapest (Hungary); Pappas, Ion [General Electric Healthcare, Akron u. 2, H-2040, Budaoers (Hungary)

    2012-08-15

    Purpose: The generation of digitally reconstructed radiographs (DRRs) is the most time consuming step on the CPU in intensity based two-dimensional x-ray to three-dimensional (CT or 3D rotational x-ray) medical image registration, which has application in several image guided interventions. This work presents optimized DRR rendering on graphical processor units (GPUs) and compares performance achievable on four commercially available devices. Methods: A ray-cast based DRR rendering was implemented for a 512 Multiplication-Sign 512 Multiplication-Sign 72 CT volume. The block size parameter was optimized for four different GPUs for a region of interest (ROI) of 400 Multiplication-Sign 225 pixels with different sampling ratios (1.1%-9.1% and 100%). Performance was statistically evaluated and compared for the four GPUs. The method and the block size dependence were validated on the latest GPU for several parameter settings with a public gold standard dataset (512 Multiplication-Sign 512 Multiplication-Sign 825 CT) for registration purposes. Results: Depending on the GPU, the full ROI is rendered in 2.7-5.2 ms. If sampling ratio of 1.1%-9.1% is applied, execution time is in the range of 0.3-7.3 ms. On all GPUs, the mean of the execution time increased linearly with respect to the number of pixels if sampling was used. Conclusions: The presented results outperform other results from the literature. This indicates that automatic 2D to 3D registration, which typically requires a couple of hundred DRR renderings to converge, can be performed quasi on-line, in less than a second or depending on the application and hardware in less than a couple of seconds. Accordingly, a whole new field of applications is opened for image guided interventions, where the registration is continuously performed to match the real-time x-ray.

  11. New coordination polymers from 1D chain, 2D layer to 3D framework constructed from 1,2-phenylenediacetic acid and 1,3-bis(4-pyridyl)propane flexible ligands

    International Nuclear Information System (INIS)

    Xin Lingyun; Liu Guangzhen; Wang Liya

    2011-01-01

    The hydrothermal reactions of Cd, Zn, or Cu(II) acetate salts with H 2 PHDA and BPP flexible ligands afford three new coordination polymers, including [Cd(PHDA)(BPP)(H 2 O)] n (1), [Zn(PHDA)(BPP)] n (2), and [Cu 2 (PHDA) 2 (BPP)] n (3) (H 2 PHDA=1,2-phenylenediacetic acid, BPP=1,3-bis(4-pyridyl)propane). The single-crystal X-ray diffractions reveal that all three complexes feature various metal carboxylate subunits extended further by the BPP ligands to form a diverse range of structures, displaying a remarked structural sensitivity to metal(II) cation. Complex 1 containing PHDA-bridged binuclear cadmium generates 1D double-stranded chain, complex 2 results in 2D→2D interpenetrated (4,4) grids, and complex 3 displays a 3D self-penetrated framework with 4 8 6 6 8 rob topology. In addition, fluorescent analyses show that both 1 and 2 exhibit intense blue-violet photoluminescence in the solid state. - Graphical Abstract: We show diverse supramolecular frameworks based on the same ligands (PHDA and BPP) and different metal acetate salts including 1D double-stranded chain, 2D → 2D twofold interpenetrated layer, and 3D self-penetration networks. Highlights: → Three metal(II = 2 /* ROMAN ) coordination polymers were synthesized using H 2 PHDA and BPP. → The diversity of structures show a remarked sensitivity to metal(II) center. → Complexes show the enhancement of fluorescence compared to that of free ligand.

  12. Note: Coincidence measurements of 3He and neutrons from a compact D-D neutron generator

    Science.gov (United States)

    Ji, Q.; Lin, C.-J.; Tindall, C.; Garcia-Sciveres, M.; Schenkel, T.; Ludewigt, B. A.

    2017-05-01

    Tagging of neutrons (2.45 MeV) with their associated 3He particles from deuterium-deuterium (D-D) fusion reactions has been demonstrated in a compact neutron generator setup enabled by a high brightness, microwave-driven ion source with a high fraction of deuterons. Energy spectra with well separated peaks of the D-D fusion reaction products, 3He, tritons, and protons, were measured with a silicon PIN diode. The neutrons were detected using a liquid scintillator detector with pulse shape discrimination. By correlating the 3He detection events with the neutron detection in time, we demonstrated the tagging of emitted neutrons with 3He particles detected with a Si PIN diode detector mounted inside the neutron generator vacuum vessel.

  13. Analytic study of 1D diffusive relativistic shock acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Keshet, Uri, E-mail: ukeshet@bgu.ac.il [Physics Department, Ben-Gurion University of the Negev, POB 653, Be' er-Sheva 84105 (Israel)

    2017-10-01

    Diffusive shock acceleration (DSA) by relativistic shocks is thought to generate the dN / dE ∝ E{sup −p} spectra of charged particles in various astronomical relativistic flows. We show that for test particles in one dimension (1D), p {sup −1}=1−ln[γ{sub d}(1+β{sub d})]/ln[γ{sub u}(1+β{sub u})], where β{sub u}(β{sub d}) is the upstream (downstream) normalized velocity, and γ is the respective Lorentz factor. This analytically captures the main properties of relativistic DSA in higher dimensions, with no assumptions on the diffusion mechanism. Unlike 2D and 3D, here the spectrum is sensitive to the equation of state even in the ultra-relativistic limit, and (for a J(üttner-Synge equation of state) noticeably hardens with increasing 1<γ{sub u}<57, before logarithmically converging back to p (γ{sub u→∞})=2. The 1D spectrum is sensitive to drifts, but only in the downstream, and not in the ultra-relativistic limit.

  14. Study on Neutron Generation by Using Modified Prototype D-D Neutron Generator

    International Nuclear Information System (INIS)

    Kim, In-Jung; Kim, Suk-Kwon; Park, Chang-Su; Jung, Nam-Suk; Jung, Hwa-Dong; Chung, Kyoung-Jae; Hwang, Yong-Seok; Choi, H. D.

    2006-01-01

    The effects of Ti target thickness and deuteron beam energy on neutron generation in the modified prototype DD neutron generator were studied. Three kinds of Ti targets with the thickness of 10 μm, 40 μm and 1 mm were used. Deuteron beam energy was varied from 45 keV to 65 keV. The effects of target thickness and deuteron beam energy were evaluated for every set of experimental run and the results were discussed

  15. Generating Free-Form Grid Truss Structures from 3D Scanned Point Clouds

    Directory of Open Access Journals (Sweden)

    Hui Ding

    2017-01-01

    Full Text Available Reconstruction, according to physical shape, is a novel way to generate free-form grid truss structures. 3D scanning is an effective means of acquiring physical form information and it generates dense point clouds on surfaces of objects. However, generating grid truss structures from point clouds is still a challenge. Based on the advancing front technique (AFT which is widely used in Finite Element Method (FEM, a scheme for generating grid truss structures from 3D scanned point clouds is proposed in this paper. Based on the characteristics of point cloud data, the search box is adopted to reduce the search space in grid generating. A front advancing procedure suit for point clouds is established. Delaunay method and Laplacian method are used to improve the quality of the generated grids, and an adjustment strategy that locates grid nodes at appointed places is proposed. Several examples of generating grid truss structures from 3D scanned point clouds of seashells are carried out to verify the proposed scheme. Physical models of the grid truss structures generated in the examples are manufactured by 3D print, which solidifies the feasibility of the scheme.

  16. THERMAL TEXTURE GENERATION AND 3D MODEL RECONSTRUCTION USING SFM AND GAN

    Directory of Open Access Journals (Sweden)

    V. V. Kniaz

    2018-05-01

    Full Text Available Realistic 3D models with textures representing thermal emission of the object are widely used in such fields as dynamic scene analysis, autonomous driving, and video surveillance. Structure from Motion (SfM methods provide a robust approach for the generation of textured 3D models in the visible range. Still, automatic generation of 3D models from the infrared imagery is challenging due to an absence of the feature points and low sensor resolution. Recent advances in Generative Adversarial Networks (GAN have proved that they can perform complex image-to-image transformations such as a transformation of day to night and generation of imagery in a different spectral range. In this paper, we propose a novel method for generation of realistic 3D models with thermal textures using the SfM pipeline and GAN. The proposed method uses visible range images as an input. The images are processed in two ways. Firstly, they are used for point matching and dense point cloud generation. Secondly, the images are fed into a GAN that performs the transformation from the visible range to the thermal range. We evaluate the proposed method using real infrared imagery captured with a FLIR ONE PRO camera. We generated a dataset with 2000 pairs of real images captured in thermal and visible range. The dataset is used to train the GAN network and to generate 3D models using SfM. The evaluation of the generated 3D models and infrared textures proved that they are similar to the ground truth model in both thermal emissivity and geometrical shape.

  17. Design of a high-current low-energy beam transport line for an intense D-T/D-D neutron generator

    International Nuclear Information System (INIS)

    Lu, Xiaolong; Wang, Junrun; Zhang, Yu; Li, Jianyi; Xia, Li; Zhang, Jie; Ding, Yanyan; Jiang, Bing; Huang, Zhiwu; Ma, Zhanwen; Wei, Zheng; Qian, Xiangping; Xu, Dapeng; Lan, Changlin; Yao, Zeen

    2016-01-01

    An intense D-T/D-D neutron generator is currently being developed at the Lanzhou University. The Cockcroft–Walton accelerator, as a part of the neutron generator, will be used to accelerate and transport the high-current low-energy beam from the duoplasmatron ion source to the rotating target. The design of a high-current low-energy beam transport (LEBT) line and the dynamics simulations of the mixed beam were carried out using the TRACK code. The results illustrate that the designed beam line facilitates smooth transportation of a deuteron beam of 40 mA, and the number of undesired ions can be reduced effectively using two apertures.

  18. Analysis of tube vibrations in D-4 steam generator

    International Nuclear Information System (INIS)

    Mavko, B.; Peterlin, G.; Boltezar, M.

    1983-01-01

    Accelerometer data for the most exposed tube in steam generator D-4 were recorded on magnetic tape. Procedures for calculations of the most characteristic parameters were prepared for spectral analyzer on SD 360. Parameters which most satisfactorily describe the vibrations are power spectral densities peak to peak acceleration volume and root mean square displacement. Computer program was written to calculate the natural frequencies of a multispaned tube. Procedures and the computer program will be used for independent analysis of tube vibrations in Krsko D-4 type steam generator. (author)

  19. ORMGEN3D, 3-D Crack Geometry FEM Mesh Generator

    International Nuclear Information System (INIS)

    Bass, B.R.; Bryson, J.W.

    1994-01-01

    1 - Description of program or function: ORMGEN3D is a finite element mesh generator for computational fracture mechanics analysis. The program automatically generates a three-dimensional finite element model for six different crack geometries. These geometries include flat plates with straight or curved surface cracks and cylinders with part-through cracks on the outer or inner surface. Mathematical or user-defined crack shapes may be considered. The curved cracks may be semicircular, semi-elliptical, or user-defined. A cladding option is available that allows for either an embedded or penetrating crack in the clad material. 2 - Method of solution: In general, one eighth or one-quarter of the structure is modelled depending on the configuration or option selected. The program generates a core of special wedge or collapsed prism elements at the crack front to introduce the appropriate stress singularity at the crack tip. The remainder of the structure is modelled with conventional 20-node iso-parametric brick elements. Element group I of the finite element model consists of an inner core of special crack tip elements surrounding the crack front enclosed by a single layer of conventional brick elements. Eight element divisions are used in a plane orthogonal to the crack front, while the number of element divisions along the arc length of the crack front is user-specified. The remaining conventional brick elements of the model constitute element group II. 3 - Restrictions on the complexity of the problem: Maxima of 5,500 nodes, 4 layers of clad elements

  20. Search for first and second generation leptoquarks at D0

    International Nuclear Information System (INIS)

    Abachi, S.; Abbott, B.; Abolins, M.

    1995-07-01

    A search for first and second generation pair produced scalar leptoquarks has been done with the DO detector at Fermilab's p bar p machine with √s = 1.8 TeV. Leptoquarks are assumed to be strictly generational; for example, a first generation leptoquark couples only to the electron, its neutrino, and the u and d quarks. 95% C.L. mass limits of 133 GeV/c 2 and 120 GeV/c 2 for respective 100% and 50% decay branching ratios to electron plus quark for first generation scalar leptoquarks have been published. The preliminary results of a search for second generation scalar leptoquarks in the absence of a signal are mass limits of 111 GeV/c 2 and 89 GeV/c 2 for 100% and 50% decay branching ratios to muon plus quark. A feature of these mass limits is that they are independent of the unknown coupling of the leptoquark to leptons and quarks. The detection for e + e - and e-p machines depends on the strength of this coupling

  1. Development of High Intensity D-T fusion NEutron Generator (HINEG

    Directory of Open Access Journals (Sweden)

    Wu Yican

    2017-01-01

    Full Text Available A high intensity D-T fusion neutron generator (HINEG is keenly needed for the research and development (R&D of nuclear technology and safety of the advanced nuclear energy system, especially for the radiation protection and shielding. The R&D of HINEG includes two phases: HINEG-I and HINEG-II. HINEG-I is designed to have both the steady beam and pulsed beam. The neutron yield of the steady beam is up to 1012 n/s. The width of pulse neutron beam is less than 1.5 ns. HINEG-I is used for the basic neutronics study, such as measurement of nuclear data, validation of neutronics methods and software, validation of radiation protection and so on. HINEG-II aims to generate a high neutron yield of 1013 n/s neutrons by adopting high speed rotating tritium target system integrated with jet/spray array enhanced cooling techniques, and can further upgrade to obtain neutron yield of 1014~1015n/s by using of accelerators-array in a later stage. HINEG-II can be used for fundamentals research of nuclear technology including mechanism of materials radiation damage and neutronics performance of components, radiation shielding as well as other nuclear technology applications.

  2. R&D, Marketing, and the Success of Next-Generation Products

    OpenAIRE

    Elie Ofek; Miklos Sarvary

    2003-01-01

    This paper studies dynamic competition in markets characterized by the introduction of technologically advanced next-generation products. Firms invest in new product effort in an attempt to attain industry leadership, thus securing high profits and benefiting from advantages relevant for the success of future product generations. The analysis reveals that when the current leader possesses higher research and development (R&D) competence, it tends to investin R&D than rivals and to retain its ...

  3. All dispenser printed flexible 3D structured thermoelectric generators

    Science.gov (United States)

    Cao, Z.; Shi, J. J.; Torah, R. N.; Tudor, M. J.; Beeby, S. P.

    2015-12-01

    This work presents a vertically fabricated 3D thermoelectric generator (TEG) by dispenser printing on flexible polyimide substrate. This direct-write technology only involves printing of electrodes, thermoelectric active materials and structure material, which needs no masks to transfer the patterns onto the substrate. The dimension for single thermoelectric element is 2 mm × 2 mm × 0.5 mm while the distance between adjacent cubes is 1.2 mm. The polymer structure layer was used to support the electrodes which are printed to connect the top ends of the thermoelectric material and ensure the flexibility as well. The advantages and the limitations of the dispenser printed 3D TEGs will also be evaluated in this paper. The proposed method is potential to be a low-cost and scalable fabrication solution for TEGs.

  4. The Implications of 3D Thermal Structure on 1D Atmospheric Retrieval

    Energy Technology Data Exchange (ETDEWEB)

    Blecic, Jasmina; Dobbs-Dixon, Ian [NYU Abu Dhabi, Abu Dhabi (United Arab Emirates); Greene, Thomas, E-mail: jasmina@nyu.edu [NASA Ames Research Center, Space Sciece and Astrobiology Division, M.S. 245-6, Moffett Field, CA 94035 (United States)

    2017-10-20

    Using the atmospheric structure from a 3D global radiation-hydrodynamic simulation of HD 189733b and the open-source Bayesian Atmospheric Radiative Transfer (BART) code, we investigate the difference between the secondary-eclipse temperature structure produced with a 3D simulation and the best-fit 1D retrieved model. Synthetic data are generated by integrating the 3D models over the Spitzer , the Hubble Space Telescope ( HST ), and the James Web Space Telescope ( JWST ) bandpasses, covering the wavelength range between 1 and 11 μ m where most spectroscopically active species have pronounced features. Using the data from different observing instruments, we present detailed comparisons between the temperature–pressure profiles recovered by BART and those from the 3D simulations. We calculate several averages of the 3D thermal structure and explore which particular thermal profile matches the retrieved temperature structure. We implement two temperature parameterizations that are commonly used in retrieval to investigate different thermal profile shapes. To assess which part of the thermal structure is best constrained by the data, we generate contribution functions for our theoretical model and each of our retrieved models. Our conclusions are strongly affected by the spectral resolution of the instruments included, their wavelength coverage, and the number of data points combined. We also see some limitations in each of the temperature parametrizations, as they are not able to fully match the complex curvatures that are usually produced in hydrodynamic simulations. The results show that our 1D retrieval is recovering a temperature and pressure profile that most closely matches the arithmetic average of the 3D thermal structure. When we use a higher resolution, more data points, and a parametrized temperature profile that allows more flexibility in the middle part of the atmosphere, we find a better match between the retrieved temperature and pressure profile and

  5. The Implications of 3D Thermal Structure on 1D Atmospheric Retrieval

    Science.gov (United States)

    Blecic, Jasmina; Dobbs-Dixon, Ian; Greene, Thomas

    2017-10-01

    Using the atmospheric structure from a 3D global radiation-hydrodynamic simulation of HD 189733b and the open-source Bayesian Atmospheric Radiative Transfer (BART) code, we investigate the difference between the secondary-eclipse temperature structure produced with a 3D simulation and the best-fit 1D retrieved model. Synthetic data are generated by integrating the 3D models over the Spitzer, the Hubble Space Telescope (HST), and the James Web Space Telescope (JWST) bandpasses, covering the wavelength range between 1 and 11 μm where most spectroscopically active species have pronounced features. Using the data from different observing instruments, we present detailed comparisons between the temperature-pressure profiles recovered by BART and those from the 3D simulations. We calculate several averages of the 3D thermal structure and explore which particular thermal profile matches the retrieved temperature structure. We implement two temperature parameterizations that are commonly used in retrieval to investigate different thermal profile shapes. To assess which part of the thermal structure is best constrained by the data, we generate contribution functions for our theoretical model and each of our retrieved models. Our conclusions are strongly affected by the spectral resolution of the instruments included, their wavelength coverage, and the number of data points combined. We also see some limitations in each of the temperature parametrizations, as they are not able to fully match the complex curvatures that are usually produced in hydrodynamic simulations. The results show that our 1D retrieval is recovering a temperature and pressure profile that most closely matches the arithmetic average of the 3D thermal structure. When we use a higher resolution, more data points, and a parametrized temperature profile that allows more flexibility in the middle part of the atmosphere, we find a better match between the retrieved temperature and pressure profile and the

  6. Atomically Phase-Matched Second-Harmonic Generation in a 2D Crystal

    Science.gov (United States)

    2016-08-26

    OPEN ORIGINAL ARTICLE Atomically phase-matched second-harmonic generation in a 2D crystal Mervin Zhao1,2,*, Ziliang Ye1,2,*, Ryuji Suzuki3,4,*, Yu...photoluminescence mapping, Raman spectroscopy and atomic -force microscopy. (b) Image produced via scanning and gathering the SH light produced by the 3R-MoS2...arising from a single atomic layer, where the SH light elucidated important information such as the grain boundaries and electronic structure in these ultra

  7. A Modular Microfluidic Device via Multimaterial 3D Printing for Emulsion Generation.

    Science.gov (United States)

    Ji, Qinglei; Zhang, Jia Ming; Liu, Ying; Li, Xiying; Lv, Pengyu; Jin, Dongping; Duan, Huiling

    2018-03-19

    3D-printing (3DP) technology has been developing rapidly. However, limited studies on the contribution of 3DP technology, especially multimaterial 3DP technology, to droplet-microfluidics have been reported. In this paper, multimaterial 3D-printed devices for the pneumatic control of emulsion generation have been reported. A 3D coaxial flexible channel with other rigid structures has been designed and printed monolithically. Numerical and experimental studies have demonstrated that this flexible channel can be excited by the air pressure and then deform in a controllable way, which can provide the active control of droplet generation. Furthermore, a novel modular microfluidic device for double emulsion generation has been designed and fabricated, which consists of three modules: function module, T-junction module, and co-flow module. The function module can be replaced by (1) Single-inlet module, (2) Pneumatic Control Unit (PCU) module and (3) Dual-inlet module. Different modules can be easily assembled for different double emulsion production. By using the PCU module, double emulsions with different number of inner droplets have been successfully produced without complicated operation of flow rates of different phases. By using single and dual inlet module, various double emulsions with different number of encapsulated droplets or encapsulated droplets with different compositions have been successfully produced, respectively.

  8. Thermal analysis of titanium drive-in target for D-D neutron generation.

    Science.gov (United States)

    Jung, N S; Kim, I J; Kim, S J; Choi, H D

    2010-01-01

    Thermal analysis was performed for a titanium drive-in target of a D-D neutron generator. Computational fluid dynamics code CFX-5 was used in this study. To define the heat flux term for the thermal analysis, beam current profile was measured. Temperature of the target was calculated at some of the operating conditions. The cooling performance of the target was evaluated by means of the comparison of the calculated maximum target temperature and the critical temperature of titanium. Copyright 2009 Elsevier Ltd. All rights reserved.

  9. Topological Vortex and Knotted Dissipative Optical 3D Solitons Generated by 2D Vortex Solitons.

    Science.gov (United States)

    Veretenov, N A; Fedorov, S V; Rosanov, N N

    2017-12-29

    We predict a new class of three-dimensional (3D) topological dissipative optical one-component solitons in homogeneous laser media with fast saturable absorption. Their skeletons formed by vortex lines where the field vanishes are tangles, i.e., N_{c} knotted or unknotted, linked or unlinked closed lines and M unclosed lines that thread all the closed lines and end at the infinitely far soliton periphery. They are generated by embedding two-dimensional laser solitons or their complexes in 3D space after their rotation around an unclosed, infinite vortex line with topological charge M_{0} (N_{c}, M, and M_{0} are integers). With such structure propagation, the "hula-hoop" solitons form; their stability is confirmed numerically. For the solitons found, all vortex lines have unit topological charge: the number of closed lines N_{c}=1 and 2 (unknots, trefoils, and Solomon knots links); unclosed vortex lines are unknotted and unlinked, their number M=1, 2, and 3.

  10. Thermal analysis of Ti drive-in target for D-D neutron generation

    International Nuclear Information System (INIS)

    Jung, N.S.; Kim, I.J.; Kim, S.J.; Choi, H.D.

    2008-01-01

    Full text: Thermal analysis was performed for a Ti drive-in target of a D-D neutron generator. Numerical calculation was the only feasible way to obtain the information of the target temperature, since it was very difficult to measure the target temperature during neutron generation due to high voltage being applied to the target. Computational fluid dynamics code CFX-5 was used in this study. In order to define the heat flux term for the thermal analysis, the current profile of the ion beam was measured. The one-dimensional, integrated current profile was measured by using a single slit and a Faraday cup. The measured current profile was transformed into the axially symmetric two-dimensional distribution function by using the Abel inversion, which had the two-dimensional Gaussian function shape. Temperature distribution in the target was calculated at the operating condition. The influence of operational parameters like the ion beam energy, current, coolant mass flow rate and coolant inlet temperature on the target temperature was investigated

  11. A simple and low-cost fully 3D-printed non-planar emulsion generator

    KAUST Repository

    Zhang, Jiaming

    2015-12-23

    Droplet-based microfluidic devices provide a powerful platform for material, chemical and biological applications based on droplet templates. The technique traditionally utilized to fabricate microfluidic emulsion generators, i.e. soft-lithography, is complex and expensive for producing three-dimensional (3D) structures. The emergent 3D printing technology provides an attractive alternative due to its simplicity and low-cost. Recently a handful of studies have already demonstrated droplet production through 3D-printed microfluidic devices. However, these devices invariably use purely two-dimensional (2D) flow structures. Herein we apply 3D printing technology to fabricate simple and low-cost 3D miniaturized fluidic devices for droplet generation (single emulsion) and droplet-in-droplet (double emulsion) without need for surface treatment of the channel walls. This is accomplished by varying the channel diameters at the junction, so the inner liquid does not touch the outer walls. This 3D-printed emulsion generator has been successfully tested over a range of conditions. We also formulate and demonstrate, for the first time, uniform scaling laws for the emulsion drop sizes generated in different regimes, by incorporating the dynamic contact angle effects during the drop formation. Magnetically responsive microspheres are also produced with our emulsion templates, demonstrating the potential applications of this 3D emulsion generator in chemical and material engineering.

  12. CERN LEP2 constraint on 4D QED having a dynamically generated spatial dimension

    International Nuclear Information System (INIS)

    Cho, G.-C.; Izumi, Etsuko; Sugamoto, Akio

    2002-01-01

    We study 4D QED in which one spatial dimension is dynamically generated from the 3D action, following the mechanism proposed by Arkani-Hamed, Cohen, and Georgi. In this model, the generated fourth dimension is discretized by an interval parameter a. We examine the phenomenological constraint on the parameter a coming from collider experiments on the QED process e + e - →γγ. It is found that the CERN e + e - collider LEP2 experiments give the constraint of 1/a > or approx. 461 GeV. The expected bound on the same parameter a at a future e + e - linear collider is briefly discussed

  13. Hybrid mesh generation for the new generation of oil reservoir simulators: 3D extension; Generation de maillage hybride pour les simulateurs de reservoir petrolier de nouvelle generation: extension 3D

    Energy Technology Data Exchange (ETDEWEB)

    Flandrin, N.

    2005-09-15

    During the exploitation of an oil reservoir, it is important to predict the recovery of hydrocarbons and to optimize its production. A better comprehension of the physical phenomena requires to simulate 3D multiphase flows in increasingly complex geological structures. In this thesis, we are interested in this spatial discretization and we propose to extend in 3D the 2D hybrid model proposed by IFP in 1998 that allows to take directly into account in the geometry the radial characteristics of the flows. In these hybrid meshes, the wells and their drainage areas are described by structured radial circular meshes and the reservoirs are represented by structured meshes that can be a non uniform Cartesian grid or a Corner Point Geometry grids. In order to generate a global conforming mesh, unstructured transition meshes based on power diagrams and satisfying finite volume properties are used to connect the structured meshes together. Two methods have been implemented to generate these transition meshes: the first one is based on a Delaunay triangulation, the other one uses a frontal approach. Finally, some criteria are introduced to measure the quality of the transition meshes and optimization procedures are proposed to increase this quality under finite volume properties constraints. (author)

  14. Review of EPRI's steam generator R and D program

    International Nuclear Information System (INIS)

    Millett, P.J.; Welty, C.J.

    1998-01-01

    EPRI has carried out an extensive R and D program on SG technology since the mid 1970's. Very early efforts under the auspices of the Steam Generator Owners Group (SGOG) focused on developing remedial actions for the critical SG corrosion issues of denting, wastage and pitting. Fundamental work was also carried out in the development of thermal hydraulic models for vibration and wear, chemical cleaning and tube repair techniques. In the late 1980's and continuing through today, the program has shifted emphasis towards management of steam generator degradation, primarily stress corrosion cracking of the SG tubes on both the primary and secondary sides. The current Steam Generator Management Program (SGMP) carries out R and D in four areas; materials, chemistry, thermal hydraulics and non-destructive testing. The strategic goals of this program and projects put in place to achieve these goals will be reviewed in detail in this paper. (author)

  15. Search for the first generation scalar leptoquarks with D0; Recherche de leptoquarks scalaires de premiere generation aupres de D0

    Energy Technology Data Exchange (ETDEWEB)

    Cothenet, A

    2004-05-15

    This work was dedicated to the search for pairs of first generation scalar leptoquarks one decaying into ej and the other into {nu}j. The experimental data used (175,6 pb{sup -1}) is that collected during the run-II of the D0 experiment at Tevatron. The production cross-sections of scalar leptoquark pairs has been assessed at a 95% confidence level for different values of the mass. The comparison of these values with theoretical values has led us to state that for a branching ratio {beta} = 0.5 the existence of scalar leptoquarks with a mass lower than 194 GeV is not possible. For a branching ratio {beta} = 1, some scalar leptoquarks with mass < 238 GeV may be excluded while for {beta} = 0.5, some scalar leptoquarks with mass < 213 GeV are excluded.

  16. On a framework for generating PoD curves assisted by numerical simulations

    Energy Technology Data Exchange (ETDEWEB)

    Subair, S. Mohamed, E-mail: prajagopal@iitm.ac.in; Agrawal, Shweta, E-mail: prajagopal@iitm.ac.in; Balasubramaniam, Krishnan, E-mail: prajagopal@iitm.ac.in; Rajagopal, Prabhu, E-mail: prajagopal@iitm.ac.in [Indian Institute of Technology Madras, Department of Mechanical Engineering, Chennai, T.N. (India); Kumar, Anish; Rao, Purnachandra B.; Tamanna, Jayakumar [Indira Gandhi Centre for Atomic Research, Metallurgy and Materials Group, Kalpakkam, T.N. (India)

    2015-03-31

    The Probability of Detection (PoD) curve method has emerged as an important tool for the assessment of the performance of NDE techniques, a topic of particular interest to the nuclear industry where inspection qualification is very important. The conventional experimental means of generating PoD curves though, can be expensive, requiring large data sets (covering defects and test conditions), and equipment and operator time. Several methods of achieving faster estimates for PoD curves using physics-based modelling have been developed to address this problem. Numerical modelling techniques are also attractive, especially given the ever-increasing computational power available to scientists today. Here we develop procedures for obtaining PoD curves, assisted by numerical simulation and based on Bayesian statistics. Numerical simulations are performed using Finite Element analysis for factors that are assumed to be independent, random and normally distributed. PoD curves so generated are compared with experiments on austenitic stainless steel (SS) plates with artificially created notches. We examine issues affecting the PoD curve generation process including codes, standards, distribution of defect parameters and the choice of the noise threshold. We also study the assumption of normal distribution for signal response parameters and consider strategies for dealing with data that may be more complex or sparse to justify this. These topics are addressed and illustrated through the example case of generation of PoD curves for pulse-echo ultrasonic inspection of vertical surface-breaking cracks in SS plates.

  17. Reduction in 14 MeV neutron generation rate by ICRF injection in D-3He burning plasmas

    International Nuclear Information System (INIS)

    Matsuura, Hideaki; Nakao, Yasuyuki

    2004-01-01

    The triton distribution function during ion cyclotron range of frequency (ICRF) waves injection in D- 3 He plasmas is examined by solving the 2-dimensional Fokker-Planck equation. Triton distribution function originally has a non-Maxwellian (tail) component around 1.01 MeV birth energy range due to D(d,p)T fusion reaction. Owing to the extension of the original tail by ICRF injection, the high-energy resonance tritons further increase, and the velocity-averaged T(d,n) 4 He fusion reaction rate coefficient, i.e. 14 MeV neutron generation rate, decreases from the values when triton is assumed to be Maxwellian. It is shown that when tritons absorb ∼1/200 of the fusion power from the waves in typical D- 3 He plasma, i.e. T=80 keV, n D =2x10 20 m -3 , τ E0 =3 sec and B=6T, the 14 MeV neutron generation rate is reduced by about ∼20% from the values for Maxwellian plasmas. (author)

  18. MULTI SENSOR DATA INTEGRATION FOR AN ACCURATE 3D MODEL GENERATION

    Directory of Open Access Journals (Sweden)

    S. Chhatkuli

    2015-05-01

    Full Text Available The aim of this paper is to introduce a novel technique of data integration between two different data sets, i.e. laser scanned RGB point cloud and oblique imageries derived 3D model, to create a 3D model with more details and better accuracy. In general, aerial imageries are used to create a 3D city model. Aerial imageries produce an overall decent 3D city models and generally suit to generate 3D model of building roof and some non-complex terrain. However, the automatically generated 3D model, from aerial imageries, generally suffers from the lack of accuracy in deriving the 3D model of road under the bridges, details under tree canopy, isolated trees, etc. Moreover, the automatically generated 3D model from aerial imageries also suffers from undulated road surfaces, non-conforming building shapes, loss of minute details like street furniture, etc. in many cases. On the other hand, laser scanned data and images taken from mobile vehicle platform can produce more detailed 3D road model, street furniture model, 3D model of details under bridge, etc. However, laser scanned data and images from mobile vehicle are not suitable to acquire detailed 3D model of tall buildings, roof tops, and so forth. Our proposed approach to integrate multi sensor data compensated each other’s weakness and helped to create a very detailed 3D model with better accuracy. Moreover, the additional details like isolated trees, street furniture, etc. which were missing in the original 3D model derived from aerial imageries could also be integrated in the final model automatically. During the process, the noise in the laser scanned data for example people, vehicles etc. on the road were also automatically removed. Hence, even though the two dataset were acquired in different time period the integrated data set or the final 3D model was generally noise free and without unnecessary details.

  19. Algorithm for calculating synthetic seismograms in a layered half-space with application of matrix impedance

    Science.gov (United States)

    Pavlov, V. M.

    2013-01-01

    A new algorithm is proposed for calculating the complete synthetic seismograms from a point source in the form of the sum of a single force and a dipole with an arbitrary seismic moment tensor in a plane layered medium composed of homogenous elastic isotropic layers. Following the idea of (Alekseev and Mikhailenko, 1978), an artificial cylindrical boundary is introduced, on which the boundary conditions are specified. For this modified problem, the exact solution (in terms of the displacements and stresses on the horizontal plane areal element) in the frequency domain is derived and substantiated. The unknown depth-dependent coefficients form the motion-stress vector, whose components satisfy the known system of ordinary differential equations. This system is solved by the method that involves the matrix impedance and propagator for the vector of motion, as previously suggested by the author in (Pavlov, 2009). In relation to the initial problem, the reflections from the artificial boundary are noise, which, to a certain degree, can be suppressed by selecting a long enough distance to this boundary and owing to the presence of a purely imaginary addition to the frequency. The algorithm is not constrained by the thickness of the layers, is applicable for any frequency range, and is suitable for computing the static offset.

  20. Estimation of regional building-related C&D debris generation and composition: case study for Florida, US.

    Science.gov (United States)

    Cochran, Kimberly; Townsend, Timothy; Reinhart, Debra; Heck, Howell

    2007-01-01

    Methodology for the accounting, generation, and composition of building-related construction and demolition (C&D) at a regional level was explored. Six specific categories of debris were examined: residential construction, nonresidential construction, residential demolition, nonresidential demolition, residential renovation, and nonresidential renovation. Debris produced from each activity was calculated as the product of the total area of activity and waste generated per unit area of activity. Similarly, composition was estimated as the product of the total area of activity and the amount of each waste component generated per unit area. The area of activity was calculated using statistical data, and individual site studies were used to assess the average amount of waste generated per unit area. The application of the methodology was illustrated using Florida, US approximately 3,750,000 metric tons of building-related C&D debris were estimated as generated in Florida in 2000. Of that amount, concrete represented 56%, wood 13%, drywall 11%, miscellaneous debris 8%, asphalt roofing materials 7%, metal 3%, cardboard 1%, and plastic 1%. This model differs from others because it accommodates regional construction styles and available data. The resulting generation amount per capita is less than the US estimate - attributable to the high construction, low demolition activity seen in Florida.

  1. Simulation of current generation in a 3-D plasma model

    International Nuclear Information System (INIS)

    Tsung, F.S.; Dawson, J.M.

    1996-01-01

    Two wires carrying current in the same direction will attract each other, and two wires carrying current in the opposite direction will repel each other. Now, consider a test charge in a plasma. If the test charge carries current parallel to the plasma, then it will be pulled toward the plasma core, and if the test charge carries current anti-parallel to the plasma, then it will be pushed to the edge. The electromagnetic coupling between the plasma and a test charge (i.e., the A parallel circ v parallel term in the test charge's Hamiltonian) breaks the symmetry in the parallel direction, and gives rise to a diffusion coefficient which is dependent on the particle's parallel velocity. This is the basis for the open-quotes preferential lossclose quotes mechanism described in the work by Nunan et al. In our previous 2+1/2 D work, in both cylindrical and toroidal geometries, showed that if the plasma column is centrally fueled, then an initial current increases steadily. The results in straight, cylindrical plasmas showed that self generated parallel current arises without trapped particle or neoclassical diffusion, as assumed by the bootstrap theory. It suggests that the fundamental mechanism seems to be the conservation of particles canonical momenta in the direction of the ignorable coordinate. We have extended the simulation to 3D to verify the model put forth. A scalable 3D EM-PIC code, with a localized field-solver, has been implemented to run on a large class of parallel computers. On the 512-node SP2 at Cornell Theory Center, we have benchmarked the 2+1/2 D calculations using 32 grids in the previously ignored direction, and a 100-fold increase in the number of particles. Our preliminary results show good agreements between the 2+1/2 D and the 3D calculations. We will present our 3D results at the meeting

  2. Utilization of low voltage D-T neutron generators in neutron physics studies

    Energy Technology Data Exchange (ETDEWEB)

    Singkarat, S.

    1995-08-01

    In a small nuclear laboratory of a developing country a low voltage D-T neutron generator can be a very useful scientific apparatus. Such machines have been used successfully for more than 40 years in teaching and scientific research. The original continuous mode 150-kV D-T neutron generator has been modified to have also a capability of producing 2-ns pulsed neutrons. Together with a carefully designed 10 m long flight path collimator and shielding of a 25 cm diameter {center_dot} 10 cm thick BC-501 neutron detector, the pulsing system was successfully used for measuring the double differential cross-section (DDX) of natural iron for 14.1-MeV neutron from the angle of 30 deg to 150 deg in 10 deg steps. In order to extend the utility of the generator, two methods for converting the almost monoenergetic 14-MeV neutrons to monoenergetic neutrons of lower energy were proposed and tested. The first method uses a pulsed neutron generator and the second method uses an ordinary continuous mode generator. The latter method was successfully used to measure the scintillation light output of a 1.4 cm diameter spherical NE-213 scintillation detector. The neutron generator has also been used in the continuous search for improved neutron detection techniques. There is a proposal, based on Monte Carlo calculations, of using a scintillation fiber for a fast neutron spectrometer. Due to the slender shape of the fiber, the pattern of produced light gives a peak in the pulse height spectrum instead of the well-known rectangular-like distribution, when the fiber is bombarded end-on by a beam of 14-MeV neutrons. Experimental investigations were undertaken. Detailed investigations on the light transportation property of a short fiber were performed. The predicted peak has not yet been found but the fiber detector may be developed as a directional discrimination fast neutron detector. 18 refs.

  3. Utilization of low voltage D-T neutron generators in neutron physics studies

    International Nuclear Information System (INIS)

    Singkarat, S.

    1995-01-01

    In a small nuclear laboratory of a developing country a low voltage D-T neutron generator can be a very useful scientific apparatus. Such machines have been used successfully for more than 40 years in teaching and scientific research. The original continuous mode 150-kV D-T neutron generator has been modified to have also a capability of producing 2-ns pulsed neutrons. Together with a carefully designed 10 m long flight path collimator and shielding of a 25 cm diameter · 10 cm thick BC-501 neutron detector, the pulsing system was successfully used for measuring the double differential cross-section (DDX) of natural iron for 14.1-MeV neutron from the angle of 30 deg to 150 deg in 10 deg steps. In order to extend the utility of the generator, two methods for converting the almost monoenergetic 14-MeV neutrons to monoenergetic neutrons of lower energy were proposed and tested. Both designs used the neutron-proton interaction at a circular surface-of-revolution made of hydrocarbon materials. The first design is for a pulsed neutron generator and the second design is for an ordinary continuous mode generator. The latter method was successfully used to measure the scintillation light output of a 1.4 cm diameter spherical NE-213 scintillation detector. The neutron generator has also been used in the continuous search for improved neutron detection techniques. There is a proposal, based on Monte Carlo calculations, of using a scintillation fiber for a fast neutron spectrometer. Due to the slender shape of the fiber, the pattern of produced light gives a peak in the pulse height spectrum instead of the well-known rectangular-like distribution, when the fiber is bombarded end-on by a beam of 14-MeV neutrons. Experimental investigations were undertaken. Detailed investigations on the light transportation property of a short fiber were performed. The predicted peak has not yet been found but the fiber detector may be developed as a directional discrimination fast neutron

  4. V-Man Generation for 3-D Real Time Animation. Chapter 5

    Science.gov (United States)

    Nebel, Jean-Christophe; Sibiryakov, Alexander; Ju, Xiangyang

    2007-01-01

    The V-Man project has developed an intuitive authoring and intelligent system to create, animate, control and interact in real-time with a new generation of 3D virtual characters: The V-Men. It combines several innovative algorithms coming from Virtual Reality, Physical Simulation, Computer Vision, Robotics and Artificial Intelligence. Given a high-level task like "walk to that spot" or "get that object", a V-Man generates the complete animation required to accomplish the task. V-Men synthesise motion at runtime according to their environment, their task and their physical parameters, drawing upon its unique set of skills manufactured during the character creation. The key to the system is the automated creation of realistic V-Men, not requiring the expertise of an animator. It is based on real human data captured by 3D static and dynamic body scanners, which is then processed to generate firstly animatable body meshes, secondly 3D garments and finally skinned body meshes.

  5. Interaction of environmental contaminants with zebrafish organic anion transporting polypeptide, Oatp1d1 (Slco1d1)

    Energy Technology Data Exchange (ETDEWEB)

    Popovic, Marta; Zaja, Roko [Laboratory for Molecular Ecotoxicology, Division for Marine and Environmental Research, Rudjer Boskovic Institute, Bijenicka 54, 10 000 Zagreb (Croatia); Fent, Karl [University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Gründenstrasse 40, CH-4132 Muttenz (Switzerland); Swiss Federal Institute of Technology (ETH Zürich), Department of Environmental System Sciences, Institute of Biogeochemistry and Pollution Dynamics, CH-8092 Zürich (Switzerland); Smital, Tvrtko, E-mail: smital@irb.hr [Laboratory for Molecular Ecotoxicology, Division for Marine and Environmental Research, Rudjer Boskovic Institute, Bijenicka 54, 10 000 Zagreb (Croatia)

    2014-10-01

    Polyspecific transporters from the organic anion transporting polypeptide (OATP/Oatp) superfamily mediate the uptake of a wide range of compounds. In zebrafish, Oatp1d1 transports conjugated steroid hormones and cortisol. It is predominantly expressed in the liver, brain and testes. In this study we have characterized the transport of xenobiotics by the zebrafish Oatp1d1 transporter. We developed a novel assay for assessing Oatp1d1 interactors using the fluorescent probe Lucifer yellow and transient transfection in HEK293 cells. Our data showed that numerous environmental contaminants interact with zebrafish Oatp1d1. Oatp1d1 mediated the transport of diclofenac with very high affinity, followed by high affinity towards perfluorooctanesulfonic acid (PFOS), nonylphenol, gemfibrozil and 17α-ethinylestradiol; moderate affinity towards carbaryl, diazinon and caffeine; and low affinity towards metolachlor. Importantly, many environmental chemicals acted as strong inhibitors of Oatp1d1. A strong inhibition of Oatp1d1 transport activity was found by perfluorooctanoic acid (PFOA), chlorpyrifos-methyl, estrone (E1) and 17β-estradiol (E2), followed by moderate to low inhibition by diethyl phthalate, bisphenol A, 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4 tetrahydronapthalene and clofibrate. In this study we identified Oatp1d1 as a first Solute Carrier (SLC) transporter involved in the transport of a wide range of xenobiotics in fish. Considering that Oatps in zebrafish have not been characterized before, our work on zebrafish Oatp1d1 offers important new insights on the understanding of uptake processes of environmental contaminants, and contributes to the better characterization of zebrafish as a model species. - Highlights: • We optimized a novel assay for determination of Oatp1d1 interactors • Oatp1d1 is the first SLC characterized fish xenobiotic transporter • PFOS, nonylphenol, diclofenac, EE2, caffeine are high affinity Oatp1d1substrates • PFOA, chlorpyrifos

  6. Interaction of environmental contaminants with zebrafish organic anion transporting polypeptide, Oatp1d1 (Slco1d1)

    International Nuclear Information System (INIS)

    Popovic, Marta; Zaja, Roko; Fent, Karl; Smital, Tvrtko

    2014-01-01

    Polyspecific transporters from the organic anion transporting polypeptide (OATP/Oatp) superfamily mediate the uptake of a wide range of compounds. In zebrafish, Oatp1d1 transports conjugated steroid hormones and cortisol. It is predominantly expressed in the liver, brain and testes. In this study we have characterized the transport of xenobiotics by the zebrafish Oatp1d1 transporter. We developed a novel assay for assessing Oatp1d1 interactors using the fluorescent probe Lucifer yellow and transient transfection in HEK293 cells. Our data showed that numerous environmental contaminants interact with zebrafish Oatp1d1. Oatp1d1 mediated the transport of diclofenac with very high affinity, followed by high affinity towards perfluorooctanesulfonic acid (PFOS), nonylphenol, gemfibrozil and 17α-ethinylestradiol; moderate affinity towards carbaryl, diazinon and caffeine; and low affinity towards metolachlor. Importantly, many environmental chemicals acted as strong inhibitors of Oatp1d1. A strong inhibition of Oatp1d1 transport activity was found by perfluorooctanoic acid (PFOA), chlorpyrifos-methyl, estrone (E1) and 17β-estradiol (E2), followed by moderate to low inhibition by diethyl phthalate, bisphenol A, 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4 tetrahydronapthalene and clofibrate. In this study we identified Oatp1d1 as a first Solute Carrier (SLC) transporter involved in the transport of a wide range of xenobiotics in fish. Considering that Oatps in zebrafish have not been characterized before, our work on zebrafish Oatp1d1 offers important new insights on the understanding of uptake processes of environmental contaminants, and contributes to the better characterization of zebrafish as a model species. - Highlights: • We optimized a novel assay for determination of Oatp1d1 interactors • Oatp1d1 is the first SLC characterized fish xenobiotic transporter • PFOS, nonylphenol, diclofenac, EE2, caffeine are high affinity Oatp1d1substrates • PFOA, chlorpyrifos

  7. Charm and beauty production in D*μ events at H1/HERA

    International Nuclear Information System (INIS)

    Lucaci-Timoce, A.I.

    2007-07-01

    Charm and beauty photoproduction is investigated with the H1 detector at HERA using events with a reconstructed D * meson and a muon. Data taken during the years 1999-2000 and 2004-2006, corresponding to a total integrated luminosity of 320 pb -1 , are analysed. The D * mesons with transverse momentum p t (D * )>1.5 GeV and pseudorapidity vertical stroke η(D * ) vertical stroke *± →D (-)0 π s ± →(K -+ π ± )π s ± . In addition, muons with momentum p(μ)>2 GeV and vertical stroke η(μ) vertical stroke * meson and the muon. The charm and beauty cross sections were measured in photoproduction, i.e. for photon virtualities Q 2 2 , and for inelasticities 0.05 vis (ep→ec anti cX→eD *± μX)=314±33(stat)±101(syst)pb σ vis (ep→eb anti bX→eD *± μX)=90±20(stat)±26(syst)pb. The measurements are compared to leading order QCD calculations supplemented with parton showers as predicted by the PYTHIA Monte Carlo event generator. A ratio data/theory of 1.2±0.1(stat)±0.4(syst) and of 1.3±0.3(stat)±0.4(syst) is obtained for charm and beauty, respectively. Differential cross sections for the variables describing the D * μ system like transverse momentum p t (D * μ), pseudorapidity η(D * μ), invariant mass M(D * μ) and inelasticity y(D * μ) are measured and compared to the PYTHIA and the CASCADE Monte Carlo event generators. The theoretical models describe the shape of the differential distributions. Transverse momentum studies of the D * μ pair indicate a sensitivity to differing implementations of QCD dynamics in the simulation programs. (orig.)

  8. MESH2D Grid generator design and use

    Energy Technology Data Exchange (ETDEWEB)

    Flach, G. P. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-10-31

    Mesh2d is a Fortran90 program originally designed to generate two-dimensional structured grids of the form [x(i),y(i,j)] where [x,y] are grid coordinates identified by indices (i,j). x-coordinates depending only on index i implies strictly vertical x-grid lines, whereas the y-grid lines can undulate. Mesh2d also assigns an integer material type to each grid cell, mtyp(i,j), in a user-specified manner. The complete grid is specified through three separate input files defining the x(i), y(i,j), and mtyp(i,j) variations. Since the original development effort, Mesh2d has been extended to more general two-dimensional structured grids of the form [x(i,j),(i,j)].

  9. 1,5-Anhydro-D-fructose from D-fructose

    DEFF Research Database (Denmark)

    Dekany, Gyula; Lundt, Inge; Niedermaier, Fabian

    2007-01-01

    1,5-Anhydro-D-fructose was efficiently prepared from D-fructose via regiospecific 1,5-anhydro ring formation of 2,3-O-isopropylidene-1-O-methyl(tolyl)sulfonyl-D-fructopyranose and subsequent deprotection.......1,5-Anhydro-D-fructose was efficiently prepared from D-fructose via regiospecific 1,5-anhydro ring formation of 2,3-O-isopropylidene-1-O-methyl(tolyl)sulfonyl-D-fructopyranose and subsequent deprotection....

  10. 4d N=1 from 6d (1,0)

    Energy Technology Data Exchange (ETDEWEB)

    Razamat, Shlomo S. [Physics Department, Technion,Haifa, 32000 (Israel); Vafa, Cumrun [Jefferson Physical Laboratory, Harvard University,Cambridge, MA 02138 (United States); Zafrir, Gabi [Physics Department, Technion,Haifa, 32000 (Israel); Kavli IPMU (WPI), UTIAS, the University of Tokyo,Kashiwa, Chiba 277-8583 (Japan)

    2017-04-11

    We study the geometry of 4d N=1 SCFT’s arising from compactification of 6d (1,0) SCFT’s on a Riemann surface. We show that the conformal manifold of the resulting theory is characterized, in addition to moduli of complex structure of the Riemann surface, by the choice of a connection for a vector bundle on the surface arising from flavor symmetries in 6d. We exemplify this by considering the case of 4d N=1 SCFT’s arising from M5 branes probing ℤ{sub k} singularity compactified on a Riemann surface. In particular, we study in detail the four dimensional theories arising in the case of two M5 branes on ℤ{sub 2} singularity. We compute the conformal anomalies and indices of such theories in 4d and find that they are consistent with expectations based on anomaly and the moduli structure derived from the 6 dimensional perspective.

  11. A 3D stand generator for central Appalachian hardwood forests

    Science.gov (United States)

    Jingxin Wang; Yaoxiang Li; Gary W. Miller

    2002-01-01

    A 3-dimensional (3D) stand generator was developed for central Appalachian hardwood forests. It was designed for a harvesting simulator to examine the interactions of stand, harvest, and machine. The Component Object Model (COM) was used to design and implement the program. Input to the generator includes species composition, stand density, and spatial pattern. Output...

  12. Target injection and engagement for neutron generation at 1 Hz

    International Nuclear Information System (INIS)

    Komeda, Osamu; Mori, Yoshitaka; Nishimura, Yasuhiko

    2013-01-01

    Target injection is a key technology to realizing inertial fusion energy. Here we present the first demonstration of target injection and neutron generation. We injected more than 600 spherical deuterated polystyrene (C 8 D 8 ) bead targets during 10 minutes at 1 Hz. After the targets fell for a distance of 18 cm, we applied the synchronized laser-diode-pumped ultra-intense laser HAMA and successfully generated neutrons repeatedly. The result is a step toward fusion power and also suggests possible industrial neutron sources. (author)

  13. Development of earthquake early warning system using real time signal of broadband seismogram

    International Nuclear Information System (INIS)

    Gunawan, Hendar; Puspito, Nanang T.; Ibrahim, Gunawan; Harjadi, Prih

    2012-01-01

    Earthquake pose serious threat of live and properties for urban area near subduction zone offshore and active fault on land. Jakarta and Bandung is an example of big city that no system of Earthquake early warning (EEW) event very high urbanization, and has many important infra structure in the area. The capital city is potentially high risk ground shaking. EEW can be usefull tool for reducing earthquake hazard, if spatial relation between cities and earthquake source is favorable for such warning and their citizens are properly trained to response early warning message. An EEW and rapid response system can provide the critical information needed to minimized lost of live and property and direct rescue. Earthquake ground shaking with magnitude M>6.0 from zone of Megathrust, southern of West Java should potentially damage in the area of west java especially Bandung and Jakarta City. This research development of EEW parameter such as amplitude displacement (Pd), rapid magnitude determination (M) and Peak ground Velocity (PGV). We explore the practical approach to EEW with the use of Broadband seismogram signal. Time effective EEW which epicenter from megathrust zone has potential to provide EEW in the area of west java such as Jakarta first ground shaking more or less 60 second later and strong shaking 118 second after EEW Alarm on CISI Station. EEW notification at potentially damage in the area of west java can be predicted from the characteristic of Pd > 0.5 cm, M> 6 and PGV > 10 cm/sec. GIS as a tool for presentation of hazard mapping in the affected area.

  14. Design and related R and D works of 'Monju' steam generators

    Energy Technology Data Exchange (ETDEWEB)

    Nakai, Y; Imanaka, N; Hoshi, Y; Tanaka, K; Hori, M; Yoshikawa, Y

    1975-07-01

    The steam generator is considered to be one of the key components in LMFBR plant. Helical coil type steam generator is selected as a reference for the first Japanese demonstration plant 'MONJU'. The paper gives the structural and functional features of 'MONJU' steam generator together with a brief description of secondary cooling system. The related R and D works are also illustrated. (author)

  15. Radiological protection for the ANGRA 1 steam generator replacement outage

    International Nuclear Information System (INIS)

    Oliveira, Magno Jose de; Amaral, Marcos Antonio do; Minelli, Edson; Ferreira, William Alves

    2009-01-01

    The Angra 1 Nuclear Power Plant (NPP) is a Westinghouse two-loop plant with net output before its 1P16 Outage of 632 MWe, with the Old Steam Generators (OSG) type model D3, which were replaced by two new Steam Generators with feed water-ring system. Localized in Angra dos Reis, Rio de Janeiro - Brazil, Angra 1 started in commercial operation in 1985 and, from the beginning problems related to corrosion have appeared in the Inconel 600 alloy of the tubes. The corrosion problems indicated the necessity for a strong control of the tubes thicknesses and, after a time, the ELETRONUCLEAR decided to replace the OSG. In 2009, ELETRONUCLEAR initiated in January 24, the actions for the Steam Generators Replacement - SGR. During the SGR process, several controls were applied in field, which made possible to have no radiological accidents, no dose limits exceeded, and permitted to achieve a very good result in terms of Collective Dose. This paper describes the radiological controls applied for the Angra 1 Steam Generator Replacement Outage, the radiological protection team sizing and distribution and the obtained results. (author)

  16. Location of early aftershocks of the 2004 Mid-Niigata Prefecture Earthquake (M = 6.8) in central Japan using seismogram envelopes as templates

    Science.gov (United States)

    Kosuga, M.

    2013-12-01

    The location of early aftershocks is very important to obtain information of mainshock fault, however, it is often difficult due to the long-lasting coda wave of mainshock and successive occurrence of afterrshocks. To overcome this difficulty, we developed a method of location using seismogram envelopes as templates, and applied the method to the early aftershock sequence of the 2004 Mid-Niigata Prefecture (Chuetsu) Earthquake (M = 6.8) in central Japan. The location method composes of three processes. The first process is the calculation of cross-correlation coefficients between a continuous (target) and template envelopes. We prepare envelopes by taking the logarithm of root-mean-squared amplitude of band-pass filtered seismograms. We perform the calculation by shifting the time window to obtain a set of cross-correlation values for each template. The second process is the event detection (selection of template) and magnitude estimate. We search for the events in descending order of cross-correlation in a time window excluding the dead times around the previously detected events. Magnitude is calculated by the amplitude ratio of target and template envelopes. The third process is the relative event location to the selected template. We applied this method to the Chuetsu earthquake, a large inland earthquake with extensive aftershock activity. The number of detected events depends on the number of templates, frequency range, and the threshold value of cross-correlation. We set the threshold as 0.5 by referring to the histogram of cross-correlation. During a period of one-hour from the mainshock, we could detect more events than the JMA catalog. The location of events is generally near the catalog location. Though we should improve the methods of relative location and magnitude estimate, we conclude that the proposed method works adequately even just after the mainshock of large inland earthquake. Acknowledgement: We thank JMA, NIED, and the University of Tokyo for

  17. Numerical simulation of Ge solar cells using D-AMPS-1D code

    Energy Technology Data Exchange (ETDEWEB)

    Barrera, Marcela, E-mail: barrera@tandar.cnea.gov.ar [Comision Nacional de Energia Atomica, Avenida General Paz 1499, San Martin 1650, Buenos Aires (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) (Argentina); Rubinelli, Francisco [Instituto de Desarrollo Tecnologico para la Industria Quimica (INTEC)-CONICET, Gueemes 3450, Santa Fe 3000 (Argentina); Rey-Stolle, Ignacio [Instituto de Energia Solar, Universidad Politecnica de Madrid, Avenida Complutense 30, Madrid 28040 (Spain); Pla, Juan [Comision Nacional de Energia Atomica, Avenida General Paz 1499, San Martin 1650, Buenos Aires (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) (Argentina)

    2012-08-15

    A solar cell is a solid state device that converts the energy of sunlight directly into electricity by the photovoltaic effect. When light with photon energies greater than the band gap is absorbed by a semiconductor material, free electrons and free holes are generated by optical excitation in the material. The main characteristic of a photovoltaic device is the presence of internal electric field able to separate the free electrons and holes so they can pass out of the material to the external circuit before they recombine. Numerical simulation of photovoltaic devices plays a crucial role in their design, performance prediction, and comprehension of the fundamental phenomena ruling their operation. The electrical transport and the optical behavior of the solar cells discussed in this work were studied with the simulation code D-AMPS-1D. This software is an updated version of the one-dimensional (1D) simulation program Analysis of Microelectronic and Photonic Devices (AMPS) that was initially developed at The Penn State University, USA. Structures such as homojunctions, heterojunctions, multijunctions, etc., resulting from stacking layers of different materials can be studied by appropriately selecting characteristic parameters. In this work, examples of cells simulation made with D-AMPS-1D are shown. Particularly, results of Ge photovoltaic devices are presented. The role of the InGaP buffer on the device was studied. Moreover, a comparison of the simulated electrical parameters with experimental results was performed.

  18. Numerical simulation of Ge solar cells using D-AMPS-1D code

    International Nuclear Information System (INIS)

    Barrera, Marcela; Rubinelli, Francisco; Rey-Stolle, Ignacio; Plá, Juan

    2012-01-01

    A solar cell is a solid state device that converts the energy of sunlight directly into electricity by the photovoltaic effect. When light with photon energies greater than the band gap is absorbed by a semiconductor material, free electrons and free holes are generated by optical excitation in the material. The main characteristic of a photovoltaic device is the presence of internal electric field able to separate the free electrons and holes so they can pass out of the material to the external circuit before they recombine. Numerical simulation of photovoltaic devices plays a crucial role in their design, performance prediction, and comprehension of the fundamental phenomena ruling their operation. The electrical transport and the optical behavior of the solar cells discussed in this work were studied with the simulation code D-AMPS-1D. This software is an updated version of the one-dimensional (1D) simulation program Analysis of Microelectronic and Photonic Devices (AMPS) that was initially developed at The Penn State University, USA. Structures such as homojunctions, heterojunctions, multijunctions, etc., resulting from stacking layers of different materials can be studied by appropriately selecting characteristic parameters. In this work, examples of cells simulation made with D-AMPS-1D are shown. Particularly, results of Ge photovoltaic devices are presented. The role of the InGaP buffer on the device was studied. Moreover, a comparison of the simulated electrical parameters with experimental results was performed.

  19. The Menger sponge : a first exploration into 3D generated form

    NARCIS (Netherlands)

    Kennedy, R.W.R.

    2016-01-01

    In this article I describe programming a three-dimensional fractal structure as a first venture into formulaically generated forms, and the physical realisations of those structures with tereolithographic 3D printing. A Menger Sponge is generated and the implementation of the algorithm is discussed

  20. R and D investment of electricity-generating firms following industry restructuring

    International Nuclear Information System (INIS)

    Kim, Jihwan; Kim, Yeonbae; Flacher, David

    2012-01-01

    Since electricity market restructuring, questions over adequate levels of R and D investments persisted. Using an unbalanced panel data of 70 electricity-generating firms across 15 Organisations of Economic Co-operation and Development countries from 1990 to 2008, this paper empirically examines the impacts of entry liberalization (allowing third party access, establishing a wholesale market, and deregulating a retail market), vertical unbundling, privatization, and firm size on R and D investments. Entry liberalization is associated with a decline in R and D investment. Establishing a wholesale market exhibits the greatest negative effects on R and D investment. Regulated TPA and retail market deregulation also decrease R and D. The effect of privatization is not independently salient but interacts with a wholesale pool to lower R and D investments. Large firms spend more on R and D investment than small firms. Results indicate that the restructuring of the electricity industry reduces R and D investment, which may be detrimental to the reliability and the efficiency of the electricity system as well as to the creation and maintenance of the innovation capabilities necessary to address demand and environmental concerns. - Highlights: ► Entry liberalization decreases R and D outlays of electricity generating utilities. ► Establishment of a wholesale market leads to a substantial decline in R and D spending. ► Private ownership interacts with entry liberalization to lower R and D investment.

  1. Transient responses of SFG spectra of D 2O ice/CO/Pt(1 1 1) interface with irradiation of ultra-short NIR pump pulses

    Science.gov (United States)

    Kubota, Jun; Wada, Akihide; Domen, Kazunari; Kano, Satoru S.

    2002-08-01

    The behavior of D 2O ice on CO/Pt(1 1 1) and Pt(1 1 1) under the irradiation of near-IR pulses (NIR) was studied by sum-frequency generation (SFG) spectroscopy. The peaks assigned to the O-D stretching modes of ice were obtained for the first 30 molecular layers on Pt(1 1 1). When the D2O/ CO/ Pt(1 1 1) was irradiated, the signal of D 2O was weakened after 500 ps, but that of CO was weakened immediately after the pumping. A similar time response was observed for the D 2O peak in D2O/ Pt(1 1 1) . The weakening of SFG is attributed to the broadening of bands due to thermal excitation. This indicates that the energy of the pump pulse is deposited on the Pt(1 1 1) surface and diffused into the layers of D 2O ice in the 500 ps timescale.

  2. GPU accelerated generation of digitally reconstructed radiographs for 2-D/3-D image registration.

    Science.gov (United States)

    Dorgham, Osama M; Laycock, Stephen D; Fisher, Mark H

    2012-09-01

    Recent advances in programming languages for graphics processing units (GPUs) provide developers with a convenient way of implementing applications which can be executed on the CPU and GPU interchangeably. GPUs are becoming relatively cheap, powerful, and widely available hardware components, which can be used to perform intensive calculations. The last decade of hardware performance developments shows that GPU-based computation is progressing significantly faster than CPU-based computation, particularly if one considers the execution of highly parallelisable algorithms. Future predictions illustrate that this trend is likely to continue. In this paper, we introduce a way of accelerating 2-D/3-D image registration by developing a hybrid system which executes on the CPU and utilizes the GPU for parallelizing the generation of digitally reconstructed radiographs (DRRs). Based on the advancements of the GPU over the CPU, it is timely to exploit the benefits of many-core GPU technology by developing algorithms for DRR generation. Although some previous work has investigated the rendering of DRRs using the GPU, this paper investigates approximations which reduce the computational overhead while still maintaining a quality consistent with that needed for 2-D/3-D registration with sufficient accuracy to be clinically acceptable in certain applications of radiation oncology. Furthermore, by comparing implementations of 2-D/3-D registration on the CPU and GPU, we investigate current performance and propose an optimal framework for PC implementations addressing the rigid registration problem. Using this framework, we are able to render DRR images from a 256×256×133 CT volume in ~24 ms using an NVidia GeForce 8800 GTX and in ~2 ms using NVidia GeForce GTX 580. In addition to applications requiring fast automatic patient setup, these levels of performance suggest image-guided radiation therapy at video frame rates is technically feasible using relatively low cost PC

  3. Synthesis of 1,4-anhydro-D-fructose and 1,4-anhydro-D-tagatose.

    Science.gov (United States)

    Dekany, Gyula; Lundt, Inge; Steiner, Andreas J; Stütz, Arnold E

    2006-07-24

    1,4-Anhydro-D-fructose and 1,4-anhydro-D-tagatose were prepared from 1,2-O-isopropylidene-D-glucofuranose via the common intermediate 3,5,6-tri-O-benzyl-D-glucitol. The title compounds may be interesting anti-oxidants and feature activities akin to their natural pyranoid counterpart, 1,5-anhydro-D-fructose.

  4. Synthesis of 1,4-anhydro-D-fructose and 1,4-anhydro-D-tagatose

    DEFF Research Database (Denmark)

    Dekany, Gyula; Lundt, Inge; Steiner, Andreas J.

    2006-01-01

    1,4-Anhydro-D-fructose and 1,4-anhydro-D-tagatose were prepared from 1,2-O-isopropylidene-D-glucofuranose via the common intermediate 3,5,6-tri-O-benzyl-D-glucitol. The title compounds may be interesting anti-oxidants and feature activities akin to their natural pyranoid counterpart, 1,5-anhydro-D-fructose....

  5. CarSim: Automatic 3D Scene Generation of a Car Accident Description

    OpenAIRE

    Egges, A.; Nijholt, A.; Nugues, P.

    2001-01-01

    The problem of generating a 3D simulation of a car accident from a written description can be divided into two subtasks: the linguistic analysis and the virtual scene generation. As a means of communication between these two system parts, we designed a template formalism to represent a written accident report. The CarSim system processes formal descriptions of accidents and creates corresponding 3D simulations. A planning component models the trajectories and temporal values of every vehicle ...

  6. The intense neutron generator INGE-1 at the Technical University of Dresden

    International Nuclear Information System (INIS)

    Bittner, M.; Meisner, A.; Paffrath, E.; Schwiers, H.; Seeliger, D.

    1989-01-01

    The INGE-1 neutron generator developed for intergal 14 MeV neutron experiments is described. The accelerator produces steady d + ion beam in the current range of 1-10 mA with 120-240 keV energies at the target position. The beam is produced with a combined duoplasmatron focalization system on high voltage. A 30 keV beam is accelerated on final energy by a two-gap acceleration tube. The estimations conducted show that the generator maximum strength can reach up to 2x10 12 s -1 at 10 mA beam current and 220 keV energy. 4 refs

  7. ATR kinase regulates its attenuation via PPM1D phosphatase ...

    Indian Academy of Sciences (India)

    Debadrita Bhattacharya

    2018-02-07

    Feb 7, 2018 ... generated in response to ultraviolet and ionizing radiation (Lu et al. 2005a, b; Cha ... nocopy' each other's effects by uncovering persistent ATR signalling that in ...... been shown to indirectly stabilize PPM1D by mediating the.

  8. Monte Carlo simulation of explosive detection system based on a Deuterium-Deuterium (D-D) neutron generator.

    Science.gov (United States)

    Bergaoui, K; Reguigui, N; Gary, C K; Brown, C; Cremer, J T; Vainionpaa, J H; Piestrup, M A

    2014-12-01

    An explosive detection system based on a Deuterium-Deuterium (D-D) neutron generator has been simulated using the Monte Carlo N-Particle Transport Code (MCNP5). Nuclear-based explosive detection methods can detect explosives by identifying their elemental components, especially nitrogen. Thermal neutron capture reactions have been used for detecting prompt gamma emission (10.82MeV) following radiative neutron capture by (14)N nuclei. The explosive detection system was built based on a fully high-voltage-shielded, axial D-D neutron generator with a radio frequency (RF) driven ion source and nominal yield of about 10(10) fast neutrons per second (E=2.5MeV). Polyethylene and paraffin were used as moderators with borated polyethylene and lead as neutron and gamma ray shielding, respectively. The shape and the thickness of the moderators and shields are optimized to produce the highest thermal neutron flux at the position of the explosive and the minimum total dose at the outer surfaces of the explosive detection system walls. In addition, simulation of the response functions of NaI, BGO, and LaBr3-based γ-ray detectors to different explosives is described. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Effect of 24,25-dihydroxyvitamin D3 on 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] metabolism in vitamin D-deficient rats infused with 1,25-(OH)2D3

    International Nuclear Information System (INIS)

    Yamato, H.; Matsumoto, T.; Fukumoto, S.; Ikeda, K.; Ishizuka, S.; Ogata, E.

    1989-01-01

    Previous studies revealed that administration of 24,25-dihydroxyvitamin D3 [24,25-(OH)2D3] to calcium (Ca)-deficient rats causes a dose-dependent reduction in markedly elevated serum 1,25-(OH)2D3 level. Although the results suggested that the metabolism of 1,25-(OH)2D3 was accelerated by 24,25-(OH)2D3, those experiments could not define whether the enhanced metabolism of 1,25-(OH)2D3 played a role in the reduction in the serum 1,25-(OH)2D3 level. In the present study, in order to address this issue more specifically, serum 1,25-(OH)2D3 was maintained solely by exogenous administration through miniosmotic pumps of 1,25-(OH)2D3 into vitamin D-deficient rats. Thus, by measuring the serum 1,25-(OH)2D3 concentration, the effect of 24,25-(OH)2D3 on the MCR of 1,25-(OH)2D3 could be examined. Administration of 24,25-(OH)2D3 caused a dose-dependent enhancement in the MCR of 1,25-(OH)2D3, and 1 microgram/100 g rat.day 24,25-(OH)2D3, which elevated serum 24,25-(OH)2D3 to 8.6 +/- 1.3 ng/ml, significantly increased MCR and suppressed serum levels of 1,25-(OH)2D3. The effect of 24,25-(OH)2D3 on 1,25-(OH)2D3 metabolism developed with a rapid time course, and the recovery of iv injected [1 beta-3H]1,25-(OH)2D3 in blood was significantly reduced within 1 h. In addition, there was an increase in radioactivity in the water-soluble fraction of serum as well as in urine, suggesting that 1,25-(OH)2D3 is rapidly degraded to a water-soluble metabolite(s). Furthermore, the reduction in serum 1,25-(OH)2D3 was associated with a reduction in both serum and urinary Ca levels. Because the conversion of [3H]24,25-(OH)2D3 to [3H]1,24,25-(OH)2D3 or other metabolites was minimal in these rats, 24,25-(OH)2D3 appears to act without being converted into other metabolites. These results demonstrate that 24,25-(OH)2D3 rapidly stimulates the metabolism of 1,25-(OH)2D3 and reduces its serum level

  10. Fiscal 2000 survey of refuse-fueled power generation introduction technology, etc. Survey of industrial refuse-fueled power generation (Industrial refuse-fueled power generation case study implementation - 1); 2000 nendo chosa haikibutsu hatsuden donyu gijutsu chosa to - Sangyo haikibutsu hatsuden chosa (Sangyo haikibutsu hatsuden case study no jisshi - 1)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Case studies were conducted of industrial refuse-fueled power generation using plastic waste, paper waste, and wood chips, and the same using the excretions of cattle. In the study of power generation fueled by mixed waste containing plastic waste, 325t/d, 220t/d, and 130t/d incinerators having the lower calorific value of 5,960-6,401 kcal/kg were taken up, and steam conditions, generator output, generating-end efficiency, station service power ratio, sending-end efficiency, etc., were tentatively calculated. As for cost efficiency, a manufacturer's estimate indicated that commercialization would be impossible in all the cases unless the construction cost was cut down. In the study of excretion-fueled power generation, cases were taken up where medium-temperature fermentation proceeded for the excretions of 620-29,853 dairy cows (32-1,576 t/d). A calculation was performed on conditions that the construction cost and maintenance/utility costs were as estimated by the manufacturer, that the excretion treatment and power generation facilities were covered by subsidies, and that personnel expenses of 6-million yen were necessary. It was then found that there would be commercial viability in case the yield was 790t/d or higher. (NEDO)

  11. Sampling and analysis plan for Mount Plant D ampersand D soils packages, Revision 1

    International Nuclear Information System (INIS)

    1991-02-01

    There are currently 682 containers of soils in storage at Mound Plant, generated between April 1 and October 31, 1990 as a result of excavation of soils containing plutonium-238 at two ongoing Decontamination and Decommissioning (D ampersand D) Program sites. These areas are known as Area 14, the waste transfer system (WTS) hillside, and Area 17, the Special Metallurgical (SM) Building area. The soils from these areas are part of Mound Plant waste stream number AMDM-000000010, Contaminated Soil, and are proposed for shipment to the Nevada Test Site (NTS) for disposal as low-level radioactive waste. The sealed waste packages, constructed of either wood or metal, are currently being stored in Building 31 and at other locations throughout the Mound facility. At a meeting in Las Vegas, Nevada on October, 26, 1990, DOE Nevada Operations Office (DOE-NV) and NTS representatives requested that the Mound Plant D ampersand D soils proposed for shipment to NTS be sampled for Toxicity Characteristic Leaching Procedure (TCLP) constituents. On December 14, 1990, DOE-NV also requested that additional analyses be performed on the soils from one of the soils boxes for polychlorinated biphenyls (PCBs), particle size distribution, and free liquids. The purpose of this plan is to document the proposed sampling and analyses of the packages of D ampersand D soils produced prior to October 31, 1990. In order to provide a thorough description of the soils excavated from the WTS and SM areas, sections 1.1 and 1.2 provide historical Information concerning the D ampersand D soils, including waste stream evaluations and past sampling data

  12. Next generation multi-material 3D food printer concept

    NARCIS (Netherlands)

    Klomp, D.J.; Anderson, P.D.

    2017-01-01

    3D food printing is a new rapidly developing technology capable of creating food structures that are impossible to create with normal processing techniques. Challenges in this field are creating texture and multi-material food products. To address these challenges a next generation food printer will

  13. Development of a new deuterium-deuterium (D-D) neutron generator for prompt gamma-ray neutron activation analysis.

    Science.gov (United States)

    Bergaoui, K; Reguigui, N; Gary, C K; Brown, C; Cremer, J T; Vainionpaa, J H; Piestrup, M A

    2014-12-01

    A new deuterium-deuterium (D-D) neutron generator has been developed by Adelphi Technology for prompt gamma neutron activation analysis (PGNAA), neutron activation analysis (NAA), and fast neutron radiography. The generator makes an excellent fast, intermediate, and thermal neutron source for laboratories and industrial applications that require the safe production of neutrons, a small footprint, low cost, and small regulatory burden. The generator has three major components: a Radio Frequency Induction Ion Source, a Secondary Electron Shroud, and a Diode Accelerator Structure and Target. Monoenergetic neutrons (2.5MeV) are produced with a yield of 10(10)n/s using 25-50mA of deuterium ion beam current and 125kV of acceleration voltage. The present study characterizes the performance of the neutron generator with respect to neutron yield, neutron production efficiency, and the ionic current as a function of the acceleration voltage at various RF powers. In addition the Monte Carlo N-Particle Transport (MCNP) simulation code was used to optimize the setup with respect to thermal flux and radiation protection. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Generation of 3D templates of active sites of proteins with rigid prosthetic groups

    OpenAIRE

    Nebel, Jean-Christophe

    2006-01-01

    MOTIVATION: With the increasing availability of protein structures, the generation of biologically meaningful 3D patterns from the simultaneous alignment of several protein structures is an exciting prospect: active sites could be better understood, protein functions and protein 3D structures could be predicted more accurately. Although patterns can already be generated at the fold and topological levels, no system produces high-resolution 3D patterns including atom and cavity positions. To a...

  15. Desain Beam Shaping Assembly (BSA berbasis D-D Neutron Generator 2,45 MeV untuk Uji Fasilitas BNCT

    Directory of Open Access Journals (Sweden)

    Desman P. Gulo

    2015-12-01

    Full Text Available Boron Neutron Capture Therapy (BNCT is one of the cancer treatments that are being developed in nowadays. In order to support BNCT treatment for cancer that exists in underneath skin like breast cancer, the facility needs a generator that is able to produce epithermal neutron. One of the generator that is able to produce neutron is D-D neutron generator with 2.45 MeV energy. Based on the calculation of this paper, we found that the total production of neutron per second (neutron yield from Neutron Generator (NG by PSTA-BATAN Yogyakarta is 2.55×1011 n/s. The energy and flux that we found is in the range of quick neutron. Thus, it needs to be moderated to the level of epithermal neutron which is located in the interval energy of 1 eV to 10 KeV with 109 n/cm2s flux. This number is the recommendation standard from IAEA. Beam Shaping Assembly (BSA is needed in order to moderate the quick neutron to the level of epithermal neutron. One part of BSA that has the responsibility in moderating the quick neutron to epithermal neutron is the moderator. The substance of moderator used in this paper is MgF2 and A1F3. The thickness of moderator has been set in in such a way by using MCNPX software in order to fulfill the standard of IAEA. As the result of optimizing BSA moderator, the data obtain epithermal flux with the total number of 4.64×108 n/cm2/s for both of moderators with the thickness of moderator up to 15 cm. At the end of this research, the number of epithermal flux does not follow the standard of IAEA. This is because the flux neutron that is being produced by NG is relatively small. In conclusion, the NG from PSTA-BATAN Yogyakarta is not ready to be used for the BNCT treatment facility for the underneath skin cancer like breast cancer.

  16. 3D Urban Virtual Models generation methodology for smart cities

    Directory of Open Access Journals (Sweden)

    M. Álvarez

    2018-04-01

    Full Text Available Currently the use of Urban 3D Models goes beyond the mere support of three-dimensional image for the visualization of our urban surroundings. The three-dimensional Urban Models are in themselves fundamental tools to manage the different phenomena that occur in smart cities. It is therefore necessary to generate realistic models, in which BIM building design information can be integrated with GIS and other space technologies. The generation of 3D Urban Models benefit from the amount of data from sensors with the latest technologies such as airborne sensors and of the existence of international standards such as CityGML. This paper presents a methodology for the development of a three - dimensional Urban Model, based on LiDAR data and the CityGML standard, applied to the city of Lorca.

  17. FENDL/D-1.0. Decay data library for fusion applications version 1 of January 1992. Summary documentation

    International Nuclear Information System (INIS)

    Pashchenko, A.B.

    1995-01-01

    This document describes the FENDL/D-1.0 decay data library which is the sublibrary of FENDL, the evaluated nuclear data library for fusion applications. The FENDL/D-1.0 was generated by merging data from ENDF/B-6 and from ENSDF (version of May 1990) and contains the basic information for approximately 2900 nuclides and isomers needed for general activation calculations. The data are available from the IAEA Nuclear Data Section online via INTERNET by FTP command, or on magnetic tape upon request. (author). 1 tab

  18. Development of compact D-D neutron generator

    International Nuclear Information System (INIS)

    Das, Basanta Kumar; Das, Rashmita; Shyam, Anurag

    2011-12-01

    In recent years, due to specific features of compact neutron generators, their demand in elemental analysis and detection of the illicit materials has been increased in scientific community. Compact is size, controlled operation and radiation safety like features of neutron generator is suitable for research work with illicit materials. An accelerator based neutron generator can be operated in steady mode as well as in pulse mode. The main embodiment of this type of generator includes ion source, ion acceleration system and target. We are developing such type of neutron generator. This consists of one-in-house developed penning ion source, a single electrode acceleration gap and one deuterated titanium target or virgin titanium target. In this report, we will discuss various physics and technical issues related to the important components of this generator, operation of the generator and neutron detection. (author)

  19. A New Method for Generating Insulin-Secreting Cells from Human Pancreatic Epithelial Cells After Islet Isolation Transformed by NeuroD1

    Science.gov (United States)

    Shimoda, Masayuki; Chen, Shuyuan; Noguchi, Hirofumi; Takita, Morihito; Sugimoto, Koji; Itoh, Takeshi; Chujo, Daisuke; Iwahashi, Shuichi; Naziruddin, Bashoo; Levy, Marlon F.

    2014-01-01

    Abstract The generation of insulin-secreting cells from nonendocrine pancreatic epithelial cells (NEPEC) has been demonstrated for potential clinical use in the treatment of diabetes. However, previous methods either had limited efficacy or required viral vectors, which hinder clinical application. In this study, we aimed to establish an efficient method of insulin-secreting cell generation from NEPEC without viral vectors. We used nonislet fractions from both research-grade human pancreata from brain-dead donors and clinical pancreata after total pancreatectomy with autologous islet transplantation to treat chronic pancreatitis. It is of note that a few islets could be mingled in the nonislet fractions, but their influence could be limited. The NeuroD1 gene was induced into NEPEC using an effective triple lipofection method without viral vectors to generate insulin-secreting cells. The differentiation was promoted by adding a growth factor cocktail into the culture medium. Using the research-grade human pancreata, the effective method showed high efficacy in the differentiation of NEPEC into insulin-positive cells that secreted insulin in response to a glucose challenge and improved diabetes after being transplanted into diabetic athymic mice. Using the clinical pancreata, similar efficacy was obtained, even though those pancreata suffered chronic pancreatitis. In conclusion, our effective differentiation protocol with triple lipofection method enabled us to achieve very efficient insulin-secreting cell generation from human NEPEC without viral vectors. This method offers the potential for supplemental insulin-secreting cell transplantation for both allogeneic and autologous islet transplantation. PMID:24845703

  20. 3D PORFLO simulations of Loviisa steam generator

    International Nuclear Information System (INIS)

    Hovi, V.; Ilvonen, M.

    2010-01-01

    PORFLO is a 3-dimensional two-phase flow solver for porous media, developed at VTT originally by Jaakko Miettinen and now mainly by the author Ville Hovi. It is targeted at applications where 3D phenomena may be significant, but geometrical complexity does not allow for a CFD-style structure-fitted grid, such as steam generators and other heat exchangers, reactor cores or core debris beds. Basic features of PORFLO include staggered Cartesian grid and iterative solution of pressure and phase velocities (phase-coupled SIMPLE) based on 3D momentum equations, together with mass and energy equations, all for both liquid and vapour. A PORFLO model of the secondary side of a WWER-440 horizontal steam generator was developed and some preliminary simulations of its steady state operation were performed. To generate the necessary boundary condition on the primary tubes, an APROS system code model was used, from which a simple unidirectional transfer brings the tube surface temperatures to PORFLO. Feedwater is modelled by mass sources at the injection tube, with no consideration of its momentum. In the interphasial mass transfer, evaporation and condensation are considered in the bulk sense and due to the primary tubes. In momentum transfer, the interphasial drag and the drag caused by the tube bundles are modelled according to. Results of the PORFLO simulations presented here, typically in a 109 x 30 x 30 grid, include liquid and vapour velocities, void fractions and evaporation / condensation rates. Furthermore, some comparisons of PORFLO and Fluent results were made. (Authors)

  1. Stat1-Vitamin D Receptor Interactions Antagonize 1,25-Dihydroxyvitamin D Transcriptional Activity and Enhance Stat1-Mediated Transcription

    Science.gov (United States)

    Vidal, Marcos; Ramana, Chilakamarti V.; Dusso, Adriana S.

    2002-01-01

    The cytokine gamma interferon (IFN-γ) and the calcitropic steroid hormone 1,25-dihydroxyvitamin D (1,25D) are activators of macrophage immune function. In sarcoidosis, tuberculosis, and several granulomatoses, IFN-γ induces 1,25D synthesis by macrophages and inhibits 1,25D induction of 24-hydroxylase, a key enzyme in 1,25D inactivation, causing high levels of 1,25D in serum and hypercalcemia. This study delineates IFN-γ-1,25D cross talk in human monocytes-macrophages. Nuclear accumulation of Stat1 and vitamin D receptor (VDR) by IFN-γ and 1,25D promotes protein-protein interactions between Stat1 and the DNA binding domain of the VDR. This prevents VDR-retinoid X receptor (RXR) binding to the vitamin D-responsive element, thus diverting the VDR from its normal genomic target on the 24-hydroxylase promoter and antagonizing 1,25D-VDR transactivation of this gene. In contrast, 1,25D enhances IFN-γ action. Stat1-VDR interactions, by preventing Stat1 deactivation by tyrosine dephosphorylation, cooperate with IFN-γ/Stat1-induced transcription. This novel 1,25D-IFN-γ cross talk explains the pathogenesis of abnormal 1,25D homeostasis in granulomatous processes and provides new insights into 1,25D immunomodulatory properties. PMID:11909970

  2. Unambiguous metabolite identification in high-throughput metabolomics by hybrid 1D 1 H NMR/ESI MS 1 approach: Hybrid 1D 1 H NMR/ESI MS 1 metabolomics method

    Energy Technology Data Exchange (ETDEWEB)

    Walker, Lawrence R. [Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland WA 99354 USA; Hoyt, David W. [Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland WA 99354 USA; Walker, S. Michael [Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence KS 66045 USA; Ward, Joy K. [Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence KS 66045 USA; Nicora, Carrie D. [Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland WA 99354 USA; Bingol, Kerem [Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland WA 99354 USA

    2016-09-16

    We present a novel approach to improve accuracy of metabolite identification by combining direct infusion ESI MS1 with 1D 1H NMR spectroscopy. The new approach first applies standard 1D 1H NMR metabolite identification protocol by matching the chemical shift, J-coupling and intensity information of experimental NMR signals against the NMR signals of standard metabolites in metabolomics library. This generates a list of candidate metabolites. The list contains false positive and ambiguous identifications. Next, we constrained the list with the chemical formulas derived from high-resolution direct infusion ESI MS1 spectrum of the same sample. Detection of the signals of a metabolite both in NMR and MS significantly improves the confidence of identification and eliminates false positive identification. 1D 1H NMR and direct infusion ESI MS1 spectra of a sample can be acquired in parallel in several minutes. This is highly beneficial for rapid and accurate screening of hundreds of samples in high-throughput metabolomics studies. In order to make this approach practical, we developed a software tool, which is integrated to Chenomx NMR Suite. The approach is demonstrated on a model mixture, tomato and Arabidopsis thaliana metabolite extracts, and human urine.

  3. Computing K and D meson masses with N-f=2+1+1 twisted mass lattice QCD

    NARCIS (Netherlands)

    Baron, Remi; Boucaud, Philippe; Carbonell, Jaume; Drach, Vincent; Farchioni, Federico; Herdoiza, Gregorio; Jansen, Karl; Michael, Chris; Montvay, Istvan; Pallante, Elisabetta; Pene, Olivier; Reker, Siebren; Urbach, Carsten; Wagner, Marc; Wenger, Urs

    We discuss the computation of the mass of the K and D mesons within the framework of N-f = 2 + 1 + 1 twisted mass lattice QCD from a technical point of view. These quantities are essential, already at the level of generating gauge configurations, being obvious candidates to tune the strange and

  4. Flood Inundation Modelling in the Kuantan River Basin using 1D-2D Flood Modeller coupled with ASTER-GDEM

    Science.gov (United States)

    Ng, Z. F.; Gisen, J. I.; Akbari, A.

    2018-03-01

    Topography dataset is an important input in performing flood inundation modelling. However, it is always difficult to obtain high resolution topography that provide accurate elevation information. Fortunately, there are some open source topography datasets available with reasonable resolution such as SRTM and ASTER-GDEM. In Malaysia particularly in Kuantan, the modelling research on the floodplain area is still lacking. This research aims to: a) to investigate the suitability of ASTER-GDEM to be applied in the 1D-2D flood inundation modelling for the Kuantan River Basin; b) to generate flood inundation map for Kuantan river basin. The topography dataset used in this study is ASTER-GDEM to generate physical characteristics of watershed in the basin. It is used to perform rainfall runoff modelling for hydrological studies and to delineate flood inundation area in the Flood Modeller. The results obtained have shown that a 30m resolution ASTER-GDEM is applicable as an input for the 1D-2D flood modelling. The simulated water level in 2013 has NSE of 0.644 and RSME of 1.259. As a conclusion, ASTER-GDEM can be used as one alternative topography datasets for flood inundation modelling. However, the flood level obtained from the hydraulic modelling shows low accuracy at flat urban areas.

  5. Charm and beauty production in D{sup *}{mu} events at H1/HERA

    Energy Technology Data Exchange (ETDEWEB)

    Lucaci-Timoce, A.I.

    2007-07-15

    Charm and beauty photoproduction is investigated with the H1 detector at HERA using events with a reconstructed D{sup *} meson and a muon. Data taken during the years 1999-2000 and 2004-2006, corresponding to a total integrated luminosity of 320 pb{sup -1}, are analysed. The D{sup *} mesons with transverse momentum p{sub t}(D{sup *})>1.5 GeV and pseudorapidity vertical stroke {eta}(D{sup *}) vertical stroke <1.5 are reconstructed via the decay channel D{sup *{+-}}{yields}D{sup (-)0}{pi}{sub s}{sup {+-}}{yields}(K{sup -+}{pi}{sup {+-}}){pi}{sub s}{sup {+-}}. In addition, muons with momentum p({mu})>2 GeV and vertical stroke {eta}({mu}) vertical stroke <1.735 are selected. With this selection, the contribution of light quark initiated events is negligible. The fractions of charm and beauty events in data are extracted exploiting the charge and azimuthal angle correlation between the D{sup *} meson and the muon. The charm and beauty cross sections were measured in photoproduction, i.e. for photon virtualities Q{sup 2}<1 GeV{sup 2}, and for inelasticities 0.05D{sup *{+-}}{mu}X)=314{+-}33(stat){+-}101(syst)pb {sigma}{sub vis}(ep{yields}eb anti bX{yields}eD{sup *{+-}}{mu}X)=90{+-}20(stat){+-}26(syst)pb. The measurements are compared to leading order QCD calculations supplemented with parton showers as predicted by the PYTHIA Monte Carlo event generator. A ratio data/theory of 1.2{+-}0.1(stat){+-}0.4(syst) and of 1.3{+-}0.3(stat){+-}0.4(syst) is obtained for charm and beauty, respectively. Differential cross sections for the variables describing the D{sup *}{mu} system like transverse momentum p{sub t}(D{sup *}{mu}), pseudorapidity {eta}(D{sup *}{mu}), invariant mass M(D{sup *}{mu}) and inelasticity y(D{sup *}{mu}) are measured and compared to the PYTHIA and the CASCADE Monte Carlo event generators. The theoretical models describe the shape of the differential distributions. Transverse momentum studies of the D

  6. Genetic variation at minisatellite loci D1S7, D4S139, D5S110 and D17S79 among three population groups of eastern India.

    Science.gov (United States)

    Dutta, R; Kashyap, V K

    2001-04-01

    Genetic variation at four minisatellite loci D1S7, D4S139, D5S110 and D17S79 in three predominant population groups of eastern India, namely Brahmin, Kayastha and Garo, are reported in this study. The Brahmin and Kayastha are of Indo-Caucasoid origin while the Garo community represents the Indo-Mongoloid ethnic group. The methodology employed comprised generation of HaeIII-restricted fragments of isolated DNA, Southern blotting, and hybridization using chemiluminescent probes MS1, pH30, LH1 and V1 for the four loci. All four loci were highly polymorphic in the population groups. Heterozygosity values for the four loci ranged between 0.68 and 0.95. Neither departure from Hardy Weinberg expectations nor evidence of any association across alleles among the selected loci was observed. The gene differentiation value among the loci is moderate (GST = 0.027). A neighbour-joining tree constructed on the basis of the generated data shows very low genetic distance between the Brahmin and Kayastha communities in relation to the Garo. Our results based on genetic distance analysis are consistent with results of earlier studies based on serological markers and linguistic as well as morphological affiliations of these populations and their Indo-Caucasoid and Indo-Mongoloid origin. The minisatellite loci studied here were found to be not only useful in showing significant genetic variation between the populations but also to be suitable for human identity testing among eastern Indian populations.

  7. D{sub s1}{sup *}(2860) and D{sub s3}{sup *}(2860): candidates for 1D charmed-strange mesons

    Energy Technology Data Exchange (ETDEWEB)

    Song, Qin-Tao [Chinese Academy of Sciences, Nuclear Theory Group, Institute of Modern Physics, Lanzhou (China); Lanzhou University and Institute of Modern Physics of CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); University of Chinese Academy of Sciences, Beijing (China); Chen, Dian-Yong [Chinese Academy of Sciences, Nuclear Theory Group, Institute of Modern Physics, Lanzhou (China); Lanzhou University and Institute of Modern Physics of CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); Liu, Xiang [Lanzhou University and Institute of Modern Physics of CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); Lanzhou University, School of Physical Science and Technology, Lanzhou (China); Matsuki, Takayuki [Tokyo Kasei University, Tokyo (Japan); RIKEN, Theoretical Research Division, Nishina Center, Saitama (Japan)

    2015-01-01

    Newly observed two charmed-strange resonances, D{sub s1}{sup *}(2860) and D{sub s3}{sup *}(2860), are investigated by calculating their Okubo-Zweig-Iizuka-allowed strong decays, which shows that they are suitable candidates for the 1{sup 3}D{sub 1} and 1{sup 3}D{sub 3} states in the charmed-strange meson family. Our study also predicts other main decay modes of D{sub s1}{sup *}(2860) and D{sub s3}{sup *}(2860), which can be accessible at the future experiment. In addition, the decay behaviors of the spin partners of D{sub s1}{sup *}(2860) and D{sub s3}{sup *}(2860), i.e., 1D(2{sup -}) and 1D'(2{sup -}), are predicted in this work, which are still missing at present. The experimental search for the missing 1D(2{sup -}) and 1D'(2{sup -}) charmed-strange mesons is an intriguing and challenging task for further experiments. (orig.)

  8. A novel fast-neutron tomography system based on a plastic scintillator array and a compact D-D neutron generator.

    Science.gov (United States)

    Adams, Robert; Zboray, Robert; Prasser, Horst-Michael

    2016-01-01

    Very few experimental imaging studies using a compact neutron generator have been published, and to the knowledge of the authors none have included tomography results using multiple projection angles. Radiography results with a neutron generator, scintillator screen, and camera can be seen in Bogolubov et al. (2005), Cremer et al. (2012), and Li et al. (2014). Comparable results with a position-sensitive photomultiplier tube can be seen in Popov et al. (2011). One study using an array of individual fast neutron detectors in the context of cargo scanning for security purposes is detailed in Eberhardt et al. (2005). In that case, however, the emphasis was on very large objects with a resolution on the order of 1cm, whereas this study focuses on less massive objects and a finer spatial resolution. In Andersson et al. (2014) three fast neutron counters and a D-T generator were used to perform attenuation measurements of test phantoms. Based on the axisymmetry of the test phantoms, the single-projection information was used to calculate radial attenuation distributions of the object, which was compared with the known geometry. In this paper a fast-neutron tomography system based on an array of individual detectors and a purpose-designed compact D-D neutron generator is presented. Each of the 88 detectors consists of a plastic scintillator read out by two Silicon photomultipliers and a dedicated pulse-processing board. Data acquisition for all channels was handled by four single-board microcontrollers. Details of the individual detector design and testing are elaborated upon. Using the complete array, several fast-neutron images of test phantoms were reconstructed, one of which was compared with results using a Co-60 gamma source. The system was shown to be capable of 2mm resolution, with exposure times on the order of several hours per reconstructed tomogram. Details about these measurements and the analysis of the reconstructed images are given, along with a discussion

  9. Sparsity-based fast CGH generation using layer-based approach for 3D point cloud model

    Science.gov (United States)

    Kim, Hak Gu; Jeong, Hyunwook; Ro, Yong Man

    2017-03-01

    Computer generated hologram (CGH) is becoming increasingly important for a 3-D display in various applications including virtual reality. In the CGH, holographic fringe patterns are generated by numerically calculating them on computer simulation systems. However, a heavy computational cost is required to calculate the complex amplitude on CGH plane for all points of 3D objects. This paper proposes a new fast CGH generation based on the sparsity of CGH for 3D point cloud model. The aim of the proposed method is to significantly reduce computational complexity while maintaining the quality of the holographic fringe patterns. To that end, we present a new layer-based approach for calculating the complex amplitude distribution on the CGH plane by using sparse FFT (sFFT). We observe the CGH of a layer of 3D objects is sparse so that dominant CGH is rapidly generated from a small set of signals by sFFT. Experimental results have shown that the proposed method is one order of magnitude faster than recently reported fast CGH generation.

  10. Core Follow Calculation for Palo Verde Unit 1 in Cycles 1 through 4 using DeCART2D/MASTER4.0 Code System

    International Nuclear Information System (INIS)

    Jeong, Hee Jeong; Choi, Yonghee; Kim, Sungmin; Lee, Kyunghoon

    2017-01-01

    To verify and validate the DeCART2D/MASTER4.0 design system, core follow calculations of Palo Verde Unit 1(PV-1) in cycles 1 through 4 are performed. The calculation results are compared with the measured data and will be used in the generation of bias and uncertainty factors in the DeCART2D/MASTER4.0 design system. The DeCART2D/MASTER codes system has been developed in KAERI for the PWR (Pressurized water reactors) core design including SMRs (Small Modular Reactors). Core follow calculations of Pale Verde Unit 1 in Cycles 1 through 4 have been performed. Reactivities, assembly powers and startup parameters such as EPC, RW, ITC and IBW are compared with the measured data. This work will be used in the generation of bias and uncertainty factors in DeCART2D/MASTER4.0 design system.

  11. Cyclin K and cyclin D1b are oncogenic in myeloma cells

    Directory of Open Access Journals (Sweden)

    Renoir Jack-Michel

    2010-05-01

    Full Text Available Abstract Background Aberrant expression of cyclin D1 is a common feature in multiple myeloma (MM and always associated with mantle cell lymphoma (MCL. CCND1 gene is alternatively spliced to produce two cyclin D1 mRNA isoforms which are translated in two proteins: cyclin D1a and cyclin D1b. Both isoforms are present in MM cell lines and primary cells but their relative role in the tumorigenic process is still elusive. Results To test the tumorigenic potential of cyclin D1b in vivo, we generated cell clones derived from the non-CCND1 expressing MM LP-1 cell line, synthesizing either cyclin D1b or cyclin K, a structural homolog and viral oncogenic form of cyclin D1a. Immunocompromised mice injected s.c. with LP-1K or LP-1D1b cells develop tumors at the site of injection. Genome-wide analysis of LP-1-derived cells indicated that several cellular processes were altered by cyclin D1b and/or cyclin K expression such as cell metabolism, signal transduction, regulation of transcription and translation. Importantly, cyclin K and cyclin D1b have no major action on cell cycle or apoptosis regulatory genes. Moreover, they impact differently cell functions. Cyclin K-expressing cells have lost their migration properties and display enhanced clonogenic capacities. Cyclin D1b promotes tumorigenesis through the stimulation of angiogenesis. Conclusions Our study indicates that cyclin D1b participates into MM pathogenesis via previously unrevealed actions.

  12. Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells.

    Science.gov (United States)

    Chandrasekaran, Abinaya; Avci, Hasan X; Ochalek, Anna; Rösingh, Lone N; Molnár, Kinga; László, Lajos; Bellák, Tamás; Téglási, Annamária; Pesti, Krisztina; Mike, Arpad; Phanthong, Phetcharat; Bíró, Orsolya; Hall, Vanessa; Kitiyanant, Narisorn; Krause, Karl-Heinz; Kobolák, Julianna; Dinnyés, András

    2017-12-01

    Neural progenitor cells (NPCs) from human induced pluripotent stem cells (hiPSCs) are frequently induced using 3D culture methodologies however, it is unknown whether spheroid-based (3D) neural induction is actually superior to monolayer (2D) neural induction. Our aim was to compare the efficiency of 2D induction with 3D induction method in their ability to generate NPCs, and subsequently neurons and astrocytes. Neural differentiation was analysed at the protein level qualitatively by immunocytochemistry and quantitatively by flow cytometry for NPC (SOX1, PAX6, NESTIN), neuronal (MAP2, TUBB3), cortical layer (TBR1, CUX1) and glial markers (SOX9, GFAP, AQP4). Electron microscopy demonstrated that both methods resulted in morphologically similar neural rosettes. However, quantification of NPCs derived from 3D neural induction exhibited an increase in the number of PAX6/NESTIN double positive cells and the derived neurons exhibited longer neurites. In contrast, 2D neural induction resulted in more SOX1 positive cells. While 2D monolayer induction resulted in slightly less mature neurons, at an early stage of differentiation, the patch clamp analysis failed to reveal any significant differences between the electrophysiological properties between the two induction methods. In conclusion, 3D neural induction increases the yield of PAX6 + /NESTIN + cells and gives rise to neurons with longer neurites, which might be an advantage for the production of forebrain cortical neurons, highlighting the potential of 3D neural induction, independent of iPSCs' genetic background. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  13. Fast precalculated triangular mesh algorithm for 3D binary computer-generated holograms.

    Science.gov (United States)

    Yang, Fan; Kaczorowski, Andrzej; Wilkinson, Tim D

    2014-12-10

    A new method for constructing computer-generated holograms using a precalculated triangular mesh is presented. The speed of calculation can be increased dramatically by exploiting both the precalculated base triangle and GPU parallel computing. Unlike algorithms using point-based sources, this method can reconstruct a more vivid 3D object instead of a "hollow image." In addition, there is no need to do a fast Fourier transform for each 3D element every time. A ferroelectric liquid crystal spatial light modulator is used to display the binary hologram within our experiment and the hologram of a base right triangle is produced by utilizing just a one-step Fourier transform in the 2D case, which can be expanded to the 3D case by multiplying by a suitable Fresnel phase plane. All 3D holograms generated in this paper are based on Fresnel propagation; thus, the Fresnel plane is treated as a vital element in producing the hologram. A GeForce GTX 770 graphics card with 2 GB memory is used to achieve parallel computing.

  14. Failure of inelastic N/D equations to generate the rho resonance

    International Nuclear Information System (INIS)

    Tryon, E.P.

    1975-01-01

    The effective left cut of the ππ P wave is rigorously determined by comparing the usual partial-wave dispersion relation with a new dispersion relation of the kind derived by Roskies and Roy. A recent experimental result for the inelasticity below M/sub ππ/ = 1.9 GeV is inserted into the Frye-Warnock N/D equations. The solutions are nonresonant, even when the inelasticity is increased by 50% over the experimental value. Because of the rigorous basis for the effective left cut, I conclude that the rho resonance is not generated by forces in the ππ channel

  15. A Depth Map Generation Algorithm Based on Saliency Detection for 2D to 3D Conversion

    Science.gov (United States)

    Yang, Yizhong; Hu, Xionglou; Wu, Nengju; Wang, Pengfei; Xu, Dong; Rong, Shen

    2017-09-01

    In recent years, 3D movies attract people's attention more and more because of their immersive stereoscopic experience. However, 3D movies is still insufficient, so estimating depth information for 2D to 3D conversion from a video is more and more important. In this paper, we present a novel algorithm to estimate depth information from a video via scene classification algorithm. In order to obtain perceptually reliable depth information for viewers, the algorithm classifies them into three categories: landscape type, close-up type, linear perspective type firstly. Then we employ a specific algorithm to divide the landscape type image into many blocks, and assign depth value by similar relative height cue with the image. As to the close-up type image, a saliency-based method is adopted to enhance the foreground in the image and the method combine it with the global depth gradient to generate final depth map. By vanishing line detection, the calculated vanishing point which is regarded as the farthest point to the viewer is assigned with deepest depth value. According to the distance between the other points and the vanishing point, the entire image is assigned with corresponding depth value. Finally, depth image-based rendering is employed to generate stereoscopic virtual views after bilateral filter. Experiments show that the proposed algorithm can achieve realistic 3D effects and yield satisfactory results, while the perception scores of anaglyph images lie between 6.8 and 7.8.

  16. Data quality objectives summary report in support of Hanford Generating Plant. Revision 1

    International Nuclear Information System (INIS)

    Miller, M.S.; Marske, S.G.

    1996-09-01

    The Hanford Generating Plant (HGP) consists of two 430 MW low-pressure turbine generators and is owned by the Washington Public Power Supply System (WPPSS). Steam from the N Reactor powered the HGP turbines before passing through the turbine condenser, where waste heat was transferred to the cooling water. The DOE-RL requested that Environmental Restoration Contractor (ERC) generate a sampling and analysis plan to assist in the assessment of decontamination and decommissioning (D and D) and remediation of the HGP and 11 associated Solid Waste Management Units (SWMUs). This report summarizes the results of the Data Quality Objectives planning process as applied to HGP. The characterization data will be used to better estimate the cost for D and D and remediation. These costs will be utilized in an agreement between the Department of Energy-Richland Office (DOE-RL) and the WPSS. The agreement will define which organization will perform D and D of the HGP building, external support buildings, and remediation of buildings and soils surrounding the facility. The sampling and analysis design is presented in Section 7 with Tables 7-1 and 7-3 summarizing the design, number, location, analytes, and analytical methods to be used. The purpose of the sampling is to provide the nature and depth of contaminants. In locations where it was difficult to make assumptions related to extent, the design allows for limited characterization related to extent of contamination

  17. A comparison of two methods for earthquake source inversion using strong motion seismograms

    Directory of Open Access Journals (Sweden)

    G. C. Beroza

    1994-06-01

    Full Text Available In this paper we compare two time-domain inversion methods that have been widely applied to the problem of modeling earthquake rupture using strong-motion seismograms. In the multi-window method, each point on the fault is allowed to rupture multiple times. This allows flexibility in the rupture time and hence the rupture velocity. Variations in the slip-velocity function are accommodated by variations in the slip amplitude in each time-window. The single-window method assumes that each point on the fault ruptures only once, when the rupture front passes. Variations in slip amplitude are allowed and variations in rupture velocity are accommodated by allowing the rupture time to vary. Because the multi-window method allows greater flexibility, it has the potential to describe a wider range of faulting behavior; however, with this increased flexibility comes an increase in the degrees of freedom and the solutions are comparatively less stable. We demonstrate this effect using synthetic data for a test model of the Mw 7.3 1992 Landers, California earthquake, and then apply both inversion methods to the actual recordings. The two approaches yield similar fits to the strong-motion data with different seismic moments indicating that the moment is not well constrained by strong-motion data alone. The slip amplitude distribution is similar using either approach, but important differences exist in the rupture propagation models. The single-window method does a better job of recovering the true seismic moment and the average rupture velocity. The multi-window method is preferable when rise time is strongly variable, but tends to overestimate the seismic moment. Both methods work well when the rise time is constant or short compared to the periods modeled. Neither approach can recover the temporal details of rupture propagation unless the distribution of slip amplitude is constrained by independent data.

  18. The different generation of nuclear reactors from Generation-1 to Generation-4

    International Nuclear Information System (INIS)

    Cognet, G.

    2010-01-01

    In this work author deals with the history of the development of nuclear reactors from Generation-1 to Generation-4. The fuel cycle and radioactive waste management as well as major accidents are presented, too.

  19. Search for the first generation scalar leptoquarks with D0

    International Nuclear Information System (INIS)

    Cothenet, A.

    2004-05-01

    This work was dedicated to the search for pairs of first generation scalar leptoquarks one decaying into ej and the other into νj. The experimental data used (175,6 pb -1 ) is that collected during the run-II of the D0 experiment at Tevatron. The production cross-sections of scalar leptoquark pairs has been assessed at a 95% confidence level for different values of the mass. The comparison of these values with theoretical values has led us to state that for a branching ratio β = 0.5 the existence of scalar leptoquarks with a mass lower than 194 GeV is not possible. For a branching ratio β = 1, some scalar leptoquarks with mass < 238 GeV may be excluded while for β = 0.5, some scalar leptoquarks with mass < 213 GeV are excluded

  20. CarSim: Automatic 3D Scene Generation of a Car Accident Description

    NARCIS (Netherlands)

    Egges, A.; Nijholt, A.; Nugues, P.

    2001-01-01

    The problem of generating a 3D simulation of a car accident from a written description can be divided into two subtasks: the linguistic analysis and the virtual scene generation. As a means of communication between these two system parts, we designed a template formalism to represent a written

  1. D-T neutron generator development for cancer therapy. 1980 annual progress report

    International Nuclear Information System (INIS)

    Bacon, F.M.; Walko, R.J.; Bickes, R.W. Jr.; Cowgill, D.F.; Riedel, A.A.; O'Hagan, J.B.

    1980-05-01

    This report summarizes the work completed during the first year of a two-year grant by NCI/HEW to investigate the feasibility of developing a D-T neutron generator for use in cancer therapy. Experiments have continued on the Target Test Facility (TTF) developed during a previous grant to investigate high-temperature metal hydrides for use as target materials. The high voltage reliability of the TTF has been improved so that 200 kV, 200 mA operation is now routine. In recent target tests, the D-D neutron production rate was measured to be > 1 x 10 11 /s, a rate that corresponds to a D-T neutron production rate of > 1 x 10 13 /s - the desired rate for use in cancer therapy. Deuterium concentration depth profiles in the target, measured during intense ion beam bombardment, show that deuterium is depleted near the surface of the target due to impurities implanted by the ion beam. Recent modifications of the duopigatron ion source to reduce secondary electron damage to the electrodes also improved the ion source efficiency by about 40%. An ultra high vacuum version of the TTF is now being constructed to determine if improved vacuum conditions will reduce ion source impurities to a sufficiently low level that the deuterium near the surface of the target is not depleted. Testing will begin in June 1980

  2. Stat1-Vitamin D Receptor Interactions Antagonize 1,25-Dihydroxyvitamin D Transcriptional Activity and Enhance Stat1-Mediated Transcription

    OpenAIRE

    Vidal, Marcos; Ramana, Chilakamarti V.; Dusso, Adriana S.

    2002-01-01

    The cytokine gamma interferon (IFN-γ) and the calcitropic steroid hormone 1,25-dihydroxyvitamin D (1,25D) are activators of macrophage immune function. In sarcoidosis, tuberculosis, and several granulomatoses, IFN-γ induces 1,25D synthesis by macrophages and inhibits 1,25D induction of 24-hydroxylase, a key enzyme in 1,25D inactivation, causing high levels of 1,25D in serum and hypercalcemia. This study delineates IFN-γ-1,25D cross talk in human monocytes-macrophages. Nuclear accumulation of ...

  3. Teleseism-based Relative Time Corrections for Modern Analyses of Digitized Analog Seismograms

    Science.gov (United States)

    Lee, T. A.; Ishii, M.

    2017-12-01

    With modern-day instruments and seismic networks timed by GPS systems, synchronization of data streams is all but a forgone conclusion. However, during the analog era, when each station had its own clock, comparing data timing from different stations was a far more daunting prospect. Today, with recently developed methods by which analog data can be digitized, having the ability to accurately reconcile the timings of two separate stations would open decades worth of data to modern analyses. For example, one possible and exciting application would be using noise interferometry with digitized analog data in order to investigate changing structural features (on a volcano for example) over a much longer timescale than was previously possible. With this in mind, we introduce a new approach to sync time between stations based on teleseismic arrivals. P-wave arrivals are identified at stations for pairs of earthquakes from the digital and analog eras that have nearly identical distances, locations, and depths. Assuming accurate timing of the modern data, relative time corrections between a pair of stations can then be inferred for the analog data. This method for time correction depends upon the analog stations having modern equivalents, and both having sufficiently long durations of operation to allow for recording of usable teleseismic events. The Hawaii Volcano Observatory (HVO) network is an especially ideal environment for this, as it not only has a large and well-preserved collection of analog seismograms, but also has a long operating history (1912 - present) with many of the older stations having modern equivalents. As such, the scope of this project is to calculate and apply relative time corrections to analog data from two HVO stations, HILB (1919-present) and UWE (1928-present)(HILB now part of Pacific Tsunami network). Further application of this method could be for investigation of the effects of relative clock-drift, that is, the determining factor for how

  4. Characteristics of stably expressed human dopamine D1a and D1b receptors: atypical behavior of the dopamine D1b receptor

    DEFF Research Database (Denmark)

    Pedersen, U B; Norby, B; Jensen, Anders A.

    1994-01-01

    Human dopamine D1a and D1b receptors were stably expressed in Baby Hamster Kidney (BHK) or Chinese Hamster Ovary (CHO) cells. [3H]SCH23390 saturation experiments indicated the presence of only a single binding site in the D1a expressing cell line with a Kd of 0.5 nM. In D1b expressing cell lines...

  5. Computing K and D meson masses with Nf=2+1+1 twisted mass lattice QCD

    International Nuclear Information System (INIS)

    Baron, Remi; Blossier, Benoit; Boucaud, Philippe

    2010-05-01

    We discuss the computation of the mass of the K and D mesons within the framework of N f =2+1+1 twisted mass lattice QCD from a technical point of view. These quantities are essential, already at the level of generating gauge configurations, being obvious candidates to tune the strange and charm quark masses to their physical values. In particular, we address the problems related to the twisted mass flavor and parity symmetry breaking, which arise when considering a non-degenerate (c,s) doublet. We propose and verify the consistency of three methods to extract the K and D meson masses in this framework. (orig.)

  6. Nucleic acid sequences encoding D1 and D1/D2 domains of human coxsackievirus and adenovirus receptor (CAR)

    Science.gov (United States)

    Freimuth, Paul I.

    2010-04-06

    The invention provides recombinant human CAR (coxsackievirus and adenovirus receptor) polypeptides which bind adenovirus. Specifically, polypeptides corresponding to adenovirus binding domain D1 and the entire extracellular domain of human CAR protein comprising D1 and D2 are provided. In another aspect, the invention provides nucleic acid sequences encoding these domains and expression vectors for producing the domains and bacterial cells containing such vectors. The invention also includes an isolated fusion protein comprised of the D1 polypeptide fused to a polypeptide which facilitates folding of D1 when expressed in bacteria. The functional D1 domain finds application in a therapeutic method for treating a patient infected with a CAR D1-binding virus, and also in a method for identifying an antiviral compound which interferes with viral attachment. The invention also provides a method for specifically targeting a cell for infection by a virus which binds to D1.

  7. Generation of 3D nanopatterns with smooth surfaces

    International Nuclear Information System (INIS)

    Waid, Simon; Wanzenboeck, Heinz D; Gavagnin, Marco; Bertagnolli, Emmerich; Muehlberger, Michael

    2014-01-01

    Ga implantation into Si and reactive ion etching has been previously identified as candidate techniques for the generation of 3D nanopatterns. However, the structures manufactured using these techniques exhibited impedingly high surface roughness. In this work, we investigate the source of roughness and introduce a new patterning process to solve this issue. The novel patterning process introduces an additional layer absorbing the implanted Ga, thus preventing the clustering of the implanted Ga observed with uncoated Si substrates. This process enables 3D nanopatterning with sub-100 nm lateral resolution in conjunction with smooth height transitions and surface roughness down to 4 nm root mean square. Such patterns are ideally suited for optical applications and enable the manufacturing of nanoimprint lithography templates for low-profile Fresnel lenses. (paper)

  8. 1 MV low-induction pulse generator

    International Nuclear Information System (INIS)

    Koba, G.I.; Koba, Yu.V.; Slivkov, I.N.; Sukhov, A.D.; Tarumov, Eh.Z.

    1980-01-01

    A high-voltage pulse generator is described. The generator Uses the Arkadiev-Marx circuit at 1 MV voltage and 12 kJ energy; the inductance of the discharge circuit is 1.3 μN. Low inductance of the generator has been obtained due to the use of low-inductance capacitors and employment of bifilar buses with oil barrier insulation. To provide reliable generator triggering, an ignition circuit has been developed with a resistive coupling between generator steps, based on controlled three-electrode sparkgaps with a distorted field. The generator switching time is slightly dependent on pressure and constitutes 200-300 ns. The generator efficiency is 83%

  9. Human anti-rhesus D IgG1 antibody produced in transgenic plants

    DEFF Research Database (Denmark)

    Bouquin, Thomas; Thomsen, Mads; Nielsen, Leif Kofoed

    2002-01-01

    antigen, which is responsible for alloimmunization of RhD- mothers carrying an RhD+ fetus. Anti-RhD extracted from plants specifically reacted with RhD+ cells in antiglobulin technique, and elicited a respiratory burst in human peripheral blood mononuclear cells. Plant-derived antibody had equivalent......Transgenic plants represent an alternative to cell culture systems for producing cheap and safe antibodies for diagnostic and therapeutic use. To evaluate the functional properties of a 'plantibody', we generated transgenic Arabidopsis plants expressing full-length human IgG1 against the Rhesus D...... properties to CHO cell-produced anti-RhD antibody, indicating its potential usefulness in diagnostic and therapeutic programs....

  10. 3D-SoftChip: A Novel Architecture for Next-Generation Adaptive Computing Systems

    Directory of Open Access Journals (Sweden)

    Lee Mike Myung-Ok

    2006-01-01

    Full Text Available This paper introduces a novel architecture for next-generation adaptive computing systems, which we term 3D-SoftChip. The 3D-SoftChip is a 3-dimensional (3D vertically integrated adaptive computing system combining state-of-the-art processing and 3D interconnection technology. It comprises the vertical integration of two chips (a configurable array processor and an intelligent configurable switch through an indium bump interconnection array (IBIA. The configurable array processor (CAP is an array of heterogeneous processing elements (PEs, while the intelligent configurable switch (ICS comprises a switch block, 32-bit dedicated RISC processor for control, on-chip program/data memory, data frame buffer, along with a direct memory access (DMA controller. This paper introduces the novel 3D-SoftChip architecture for real-time communication and multimedia signal processing as a next-generation computing system. The paper further describes the advanced HW/SW codesign and verification methodology, including high-level system modeling of the 3D-SoftChip using SystemC, being used to determine the optimum hardware specification in the early design stage.

  11. Independent and arbitrary generation of spots in the 3D space domain with computer generated holograms written on a phase-only liquid crystal spatial light modulator

    International Nuclear Information System (INIS)

    Wang, Dong; Zhang, Jian; Xia, Yang; Wang, Hao

    2012-01-01

    An improved multiple independent iterative plane algorithm, based on a projection optimization idea, is proposed for the independent and arbitrary generation of one spot or multiple spots in a speckle-suppressed 3D work-area. Details of the mathematical expressions of the algorithm are given to theoretically show how it is improved for 3D spot generation. Both simulations and experiments are conducted to investigate the performance of the algorithm for independent and arbitrary 3D spot generation in several different cases. Simulation results agree well with experimental results, which validates the effectiveness of the algorithm proposed. Several additional experiments are demonstrated for fast and independent generation of four or more spots in the 3D space domain, which confirms the capabilities and practicalities of the algorithm further. (paper)

  12. CYP2R1 mutations causing vitamin D-deficiency rickets.

    Science.gov (United States)

    Thacher, Tom D; Levine, Michael A

    2017-10-01

    CYP2R1 is the principal hepatic 25-hydroxylase responsible for the hydroxylation of parent vitamin D to 25-hydroxyvitamin D [25(OH)D]. Serum concentrations of 25(OH)D reflect vitamin D status, because 25(OH)D is the major circulating metabolite of vitamin D. The 1α-hydroxylation of 25(OH)D in the kidney by CYP27B1 generates the fully active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH) 2 D). The human CYP2R1 gene, located at 11p15.2, has five exons, coding for an enzyme with 501 amino acids. In Cyp2r1-/- knockout mice, serum 25(OH)D levels were reduced by more than 50% compared wild-type mice. Genetic polymorphisms of CYP2R1 account for some of the individual variability of circulating 25(OH)D values in the population. We review the evidence that inactivating mutations in CYP2R1 can lead to a novel form of vitamin D-deficiency rickets resulting from impaired 25-hydroxylation of vitamin D. We sequenced the promoter, exons and intron-exon flanking regions of the CYP2R1 gene in members of 12 Nigerian families with rickets in more than one family member. We found missense mutations (L99P and K242N) in affected members of 2 of 12 families. The L99P mutation had previously been reported as a homozygous defect in an unrelated child of Nigerian origin with rickets. In silico analyses predicted impaired CYP2R1 folding or reduced interaction with substrate vitamin D by L99P and K242N mutations, respectively. In vitro studies of the mutant CYP2R1 proteins in HEK293 cells confirmed normal expression levels but completely absent or markedly reduced 25-hydroxylase activity by the L99P and K242N mutations, respectively. Heterozygous subjects had more moderate biochemical and clinical features of vitamin D deficiency than homozygous subjects. After an oral bolus dose of 50,000 IU of vitamin D 2 or vitamin D 3 , heterozygous subjects had lower increases in serum 25(OH)D than control subjects, and homozygous subjects had minimal increases, supporting a semidominant

  13. Application of Adjoint Method and Spectral-Element Method to Tomographic Inversion of Regional Seismological Structure Beneath Japanese Islands

    Science.gov (United States)

    Tsuboi, S.; Miyoshi, T.; Obayashi, M.; Tono, Y.; Ando, K.

    2014-12-01

    Recent progress in large scale computing by using waveform modeling technique and high performance computing facility has demonstrated possibilities to perform full-waveform inversion of three dimensional (3D) seismological structure inside the Earth. We apply the adjoint method (Liu and Tromp, 2006) to obtain 3D structure beneath Japanese Islands. First we implemented Spectral-Element Method to K-computer in Kobe, Japan. We have optimized SPECFEM3D_GLOBE (Komatitsch and Tromp, 2002) by using OpenMP so that the code fits hybrid architecture of K-computer. Now we could use 82,134 nodes of K-computer (657,072 cores) to compute synthetic waveform with about 1 sec accuracy for realistic 3D Earth model and its performance was 1.2 PFLOPS. We use this optimized SPECFEM3D_GLOBE code and take one chunk around Japanese Islands from global mesh and compute synthetic seismograms with accuracy of about 10 second. We use GAP-P2 mantle tomography model (Obayashi et al., 2009) as an initial 3D model and use as many broadband seismic stations available in this region as possible to perform inversion. We then use the time windows for body waves and surface waves to compute adjoint sources and calculate adjoint kernels for seismic structure. We have performed several iteration and obtained improved 3D structure beneath Japanese Islands. The result demonstrates that waveform misfits between observed and theoretical seismograms improves as the iteration proceeds. We now prepare to use much shorter period in our synthetic waveform computation and try to obtain seismic structure for basin scale model, such as Kanto basin, where there are dense seismic network and high seismic activity. Acknowledgements: This research was partly supported by MEXT Strategic Program for Innovative Research. We used F-net seismograms of the National Research Institute for Earth Science and Disaster Prevention.

  14. Half century of wind power generation memoir. Part 1; Furyoku hatsuden hanseiki sono omoide. 1

    Energy Technology Data Exchange (ETDEWEB)

    Nakata, H.

    1995-12-01

    This article may be deemed an autobiography of an individual on his development of wind power generation devices. The author began to be interested in electricity while he was a pupil of primary school and during his time of middle school student, when he walked against the strong wind on an embankment, he got an idea to utilize the wind power and succeeded to generate electricity with his handmade wind power generator using a bicycle generator. Afterwards he kept interested in devices utilizing the wind power, in 1973, energy saving was widely promoted due to the oil crises, and taking that opportunity, he established single-handedly a laboratory for development of utilization of the breeze power. Since his retirement from teaching profession in the spring of 1980, he has coped with earnestly the development of wind power generators. He acquired and installed various machine tools for metal works for generators and various machines for wood works for making propellers. In this article, wind power generators using bicycle generators (direct connection type and speed increasing type), small D.C. motors (motors for driving tape recorder, motors for automobile radiator and windshield wiper, etc.) and automobile generators (D.C. generators and alternators) are explained. 11 figs.

  15. Seismic anisotropy around the Gulf of Corinth, Greece, deduced from three-component seismograms of local earthquakes and its relationship with crustal strain

    Science.gov (United States)

    Bouin, Marie-Paule; TéLlez, Julia; Bernard, Pascal

    1996-03-01

    Several thousand three-component seismograms from local earthquakes recorded during two field experiments in August 1991 and November 1992 in the Gulf of Corinth have been analyzed to detect shear wave splitting. After a first selection of the events located in the S window of the considered stations, a second very strict selection of the records is applied in order to avoid the effect of scattered or converted phases which can mimic the behavior of shear wave splitting. Two main directions of fast S wave polarization have been detected: one oriented N105°E-N120°E, the other N55°E-N75°E. The first one is perpendicular to the main direction of extension of the Gulf provided by focal mechanism, Global Positioning System measurements, and tectonic studies, and is thus consistent with the extensive-dilatancy anisotropy (EDA) model. The second direction is subparallel to the direction of the active normal fault closest to the sites. This suggests a local control of the anisotropy by these active faults, either by a local rotation of the total stress field, in which case the EDA model may still explain the anisotropy, or by the existence of a specific microstructure or macrostructure generated by the long-term fault activity (set of secondary fault planes parallel to the major one), in which case the anisotropy direction would be significantly rotated from the stress direction (about 50°). The anisotropic signature does not seem to be affected by the geology of the site (pre-Tertiary limestone and Pleistocene sediments), except for a station located on the thick Plio-Quaternary deposits of a delta, where the time delay is significantly larger.

  16. Study by Monte Carlo methods of an explosive detection system using a D-D generator and Nal (Tl) detectors

    International Nuclear Information System (INIS)

    Cevallos R, L. E.; Guzman G, K. A.; Gallego, E.; Garcia F, G.; Vega C, H. R.

    2017-10-01

    The detection of hidden explosive material is very important for national security. Using Monte Carlo methods, with the code MCNP6, several proposed configurations of a detection system with a Deuterium-Deuterium (D-D) generator, in conjunction with NaI (Tl) scintillation detectors, have been evaluated to intercept hidden explosives. The response of the system to various explosive samples such as Rdx and ammonium nitrate are analyzed as the main components of home-military explosives. The D-D generator produces fast neutrons of 2.5 MeV in a maximum field of 10 10 n/s (Dd-110) which is surrounded with high density polyethylene in order to thermalized the fast neutrons making them interact with the sample inspected, giving rise to the emission of gamma rays that generates a characteristic spectrum of the elements that constitute it, being able in this way to determine its chemical composition and identify the type of substance. The necessary shielding is evaluated to estimate the admissible operation dose, with thicknesses of lead and borated polyethylene, in order to place it at some point of the Laboratory of Neutron Measurements of the Polytechnic University of Madrid where the shielding is optimal. The results show that its functionality is promising in the field of national security for the explosives inspection. (Author)

  17. Microseismic Event Location Improvement Using Adaptive Filtering for Noise Attenuation

    Science.gov (United States)

    de Santana, F. L., Sr.; do Nascimento, A. F.; Leandro, W. P. D. N., Sr.; de Carvalho, B. M., Sr.

    2017-12-01

    In this work we show how adaptive filtering noise suppression improves the effectiveness of the Source Scanning Algorithm (SSA; Kao & Shan, 2004) in microseism location in the context of fracking operations. The SSA discretizes the time and region of interest in a 4D vector and, for each grid point and origin time, a brigthness value (seismogram stacking) is calculated. For a given set of velocity model parameters, when origin time and hypocenter of the seismic event are correct, a maximum value for coherence (or brightness) is achieved. The result is displayed on brightness maps for each origin time. Location methods such as SSA are most effective when the noise present in the seismograms is incoherent, however, the method may present false positives when the noise present in the data is coherent as occurs in fracking operations. To remove from the seismograms, the coherent noise from the pump and engines used in the operation, we use an adaptive filter. As the noise reference, we use the seismogram recorded at the station closest to the machinery employed. Our methodology was tested on semi-synthetic data. The microseismic was represented by Ricker pulses (with central frequency of 30Hz) on synthetics seismograms, and to simulate real seismograms on a surface microseismic monitoring situation, we added real noise recorded in a fracking operation to these synthetics seismograms. The results show that after the filtering of the seismograms, we were able to improve our detection threshold and to achieve a better resolution on the brightness maps of the located events.

  18. Monte Carlo simulations of a D-T neutron generator shielding for landmine detection

    International Nuclear Information System (INIS)

    Reda, A.M.

    2011-01-01

    Shielding for a D-T sealed neutron generator has been designed using the MCNP5 Monte Carlo radiation transport code. The neutron generator will be used in field for the detection of explosives, landmines, drugs and other 'threat' materials. The optimization of the detection of buried objects was started by studying the signal-to-noise ratio for different geometric conditions. - Highlights: → A landmine detection system based on neutron fast/slow analysis has been designed. → Shielding for a D-T sealed neutron generator tube has been designed using Monte Carlo radiation transport code. → Detection of buried objects was started by studying the signal-to-noise ratio for different geometric conditions. → The signal-to-background ratio optimized at one position for all depths.

  19. An Efficient Numerical Method for Computing Synthetic Seismograms for a Layered Half-space with Sources and Receivers at Close or Same Depths

    Science.gov (United States)

    Zhang, H.-m.; Chen, X.-f.; Chang, S.

    - It is difficult to compute synthetic seismograms for a layered half-space with sources and receivers at close to or the same depths using the generalized R/T coefficient method (Kennett, 1983; Luco and Apsel, 1983; Yao and Harkrider, 1983; Chen, 1993), because the wavenumber integration converges very slowly. A semi-analytic method for accelerating the convergence, in which part of the integration is implemented analytically, was adopted by some authors (Apsel and Luco, 1983; Hisada, 1994, 1995). In this study, based on the principle of the Repeated Averaging Method (Dahlquist and Björck, 1974; Chang, 1988), we propose an alternative, efficient, numerical method, the peak-trough averaging method (PTAM), to overcome the difficulty mentioned above. Compared with the semi-analytic method, PTAM is not only much simpler mathematically and easier to implement in practice, but also more efficient. Using numerical examples, we illustrate the validity, accuracy and efficiency of the new method.

  20. From AWE-GEN to AWE-GEN-2d: a high spatial and temporal resolution weather generator

    Science.gov (United States)

    Peleg, Nadav; Fatichi, Simone; Paschalis, Athanasios; Molnar, Peter; Burlando, Paolo

    2016-04-01

    A new weather generator, AWE-GEN-2d (Advanced WEather GENerator for 2-Dimension grid) is developed following the philosophy of combining physical and stochastic approaches to simulate meteorological variables at high spatial and temporal resolution (e.g. 2 km x 2 km and 5 min for precipitation and cloud cover and 100 m x 100 m and 1 h for other variables variable (temperature, solar radiation, vapor pressure, atmospheric pressure and near-surface wind). The model is suitable to investigate the impacts of climate variability, temporal and spatial resolutions of forcing on hydrological, ecological, agricultural and geomorphological impacts studies. Using appropriate parameterization the model can be used in the context of climate change. Here we present the model technical structure of AWE-GEN-2d, which is a substantial evolution of four preceding models (i) the hourly-point scale Advanced WEather GENerator (AWE-GEN) presented by Fatichi et al. (2011, Adv. Water Resour.) (ii) the Space-Time Realizations of Areal Precipitation (STREAP) model introduced by Paschalis et al. (2013, Water Resour. Res.), (iii) the High-Resolution Synoptically conditioned Weather Generator developed by Peleg and Morin (2014, Water Resour. Res.), and (iv) the Wind-field Interpolation by Non Divergent Schemes presented by Burlando et al. (2007, Boundary-Layer Meteorol.). The AWE-GEN-2d is relatively parsimonious in terms of computational demand and allows generating many stochastic realizations of current and projected climates in an efficient way. An example of model application and testing is presented with reference to a case study in the Wallis region, a complex orography terrain in the Swiss Alps.

  1. Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System

    Directory of Open Access Journals (Sweden)

    Raul Vizcardo

    2018-03-01

    Full Text Available Summary: Induced pluripotent stem cell (iPSC-derived T cells may provide future therapies for cancer patients, but those generated by current methods, such as the OP9/DLL1 system, have shown abnormalities that pose major barriers for clinical translation. Our data indicate that these iPSC-derived CD8 single-positive T cells are more like CD4+CD8+ double-positive T cells than mature naive T cells because they display phenotypic markers of developmental arrest and an innate-like phenotype after stimulation. We developed a 3D thymic culture system to avoid these aberrant developmental fates, generating a homogeneous subset of CD8αβ+ antigen-specific T cells, designated iPSC-derived thymic emigrants (iTEs. iTEs exhibit phenotypic and functional similarities to naive T cells both in vitro and in vivo, including the capacity for expansion, memory formation, and tumor suppression. These data illustrate the limitations of current methods and provide a tool to develop the next generation of iPSC-based antigen-specific immunotherapies. : A barrier for clinical application of iPSC-derived CD8 T cells using OP9/DLL1 is their abnormal biology. Vizcardo et al. show that a 3D thymic culture system enables the generation of a homogeneous antigen-specific T cell subset, named iTEs, which closely mimics naive T cells and exhibits potent anti-tumor activity. Keywords: thymopoiesis, T cell differentiation, iPSC differentiation, adoptive cell transfer, naïve T cell, recent rhymic emigrants, fetal thymus organ culture, immunotherapy, 3D culture, tumor antigen specific T cell

  2. Potencies of vitamin D analogs, 1α-hydroxyvitamin D3 , 1α-hydroxyvitamin D2 and 25-hydroxyvitamin D3 , in lowering cholesterol in hypercholesterolemic mice in vivo.

    Science.gov (United States)

    Quach, Holly P; Dzekic, Tamara; Bukuroshi, Paola; Pang, K Sandy

    2018-04-01

    Vitamin D 3 and the synthetic vitamin D analogs, 1α-hydroxyvitamin D 3 [1α(OH)D 3 ], 1α-hydroxyvitamin D 2 [1α(OH)D 2 ] and 25-hydroxyvitamin D 3 [25(OH)D 3 ] were appraised for their vitamin D receptor (VDR) associated-potencies as cholesterol lowering agents in mice in vivo. These precursors are activated in vivo: 1α(OH)D 3 and 1α(OH)D 2 are transformed by liver CYP2R1 and CYP27A1 to active VDR ligands, 1α,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] and 1α,25-dihydroxyvitamin D 2 [1,25(OH) 2 D 2 ] , respectively. 1α(OH)D 2 may also be activated by CYP24A1 to 1α,24-dihydroxyvitamin D 2 [1,24(OH) 2 D 2 ], another active VDR ligand. 25(OH)D 3 , the metabolite formed via CYP2R1 and or CYP27A1 in liver from vitamin D 3 , is activated by CYP27B1 in the kidney to 1,25(OH) 2 D 3 . In C57BL/6 mice fed the high fat/high cholesterol Western diet for 3 weeks, vitamin D analogs were administered every other day intraperitoneally during the last week of the diet. The rank order for cholesterol lowering, achieved via mouse liver small heterodimer partner (Shp) inhibition and increased cholesterol 7α-hydroxylase (Cyp7a1) expression, was: 1.75 nmol/kg 1α(OH)D 3  > 1248 nmol/kg 25(OH)D 3 (dose ratio of 0.0014) > > 1625 nmol/kg vitamin D 3 . Except for 1.21 nmol/kg 1α(OH)D 2 that failed to lower liver and plasma cholesterol contents, a significant negative correlation was observed between the liver concentration of 1,25(OH) 2 D 3 formed from the precursors and liver cholesterol levels. The composite results show that vitamin D analogs 1α(OH)D 3 and 25(OH)D 3 exhibit cholesterol lowering properties upon activation to 1,25(OH) 2 D 3 : 1α(OH)D 3 is rapidly activated by liver enzymes and 25(OH)D 3 is slowly activated by renal Cyp27b1 in mouse. Copyright © 2018 John Wiley & Sons, Ltd.

  3. Generation of a heterozygous knockout human embryonic stem cell line for the OCIAD1 locus using CRISPR/CAS9 mediated targeting: BJNhem20-OCIAD1-CRISPR-20

    Directory of Open Access Journals (Sweden)

    Deeti K. Shetty

    2016-03-01

    Full Text Available Ovarian carcinoma immuno-reactive antigen domain containing 1(OCIAD1 single copy was knocked out generating an OCIAD1 heterozygous knockout human embryonic stem line named BJNhem20-OCIAD1-CRISPR-20. The line was generated using CRISPR-Cas9D10A double nickase knockout strategy (Mali et al., 2013.

  4. ARP1400 DVI break analysis using the MARS 3.1 multi-D component

    International Nuclear Information System (INIS)

    Hwang, Moon-Kyu; Lim, Hong-Sik; Lee, Seung-Wook; Bae, Sung-Won; Chung, Bub-Dong

    2006-01-01

    The current version of MARS 3.1 has a multi-D component intended to simulate an asymmetric multidimensional fluid behavior in a reactor core, downcomer or in a steam generator, in a more realistic manner. The feature is implemented in the 1-D module of the code. As opposed to the cross flow junction modeling, the multi-D component allows for a lateral momentum transfer as well as a sheer stress. Thus, a full three-Dimensional analysis capability is available as in the case of RELAP5-3D or CATHARE. In this study the multi-D component is applied to the hypothetical accident of a DVI (Direct Vessel Injection) break in the APR1400 plant, and the results are analyzed

  5. D{sub s1}{sup ∗}(2860) and D{sub s3}{sup ∗}(2860): candidates for 1D charmed-strange mesons

    Energy Technology Data Exchange (ETDEWEB)

    Song, Qin-Tao [Nuclear Theory Group, Institute of Modern Physics, Chinese Academy of Sciences, 730000, Lanzhou (China); Research Center for Hadron and CSR Physics, Lanzhou University & Institute of Modern Physics of CAS, 730000, Lanzhou (China); University of Chinese Academy of Sciences, 100049, Beijing (China); Chen, Dian-Yong, E-mail: chendy@impcas.ac.cn [Nuclear Theory Group, Institute of Modern Physics, Chinese Academy of Sciences, 730000, Lanzhou (China); Research Center for Hadron and CSR Physics, Lanzhou University & Institute of Modern Physics of CAS, 730000, Lanzhou (China); Liu, Xiang, E-mail: xiangliu@lzu.edu.cn [Research Center for Hadron and CSR Physics, Lanzhou University & Institute of Modern Physics of CAS, 730000, Lanzhou (China); School of Physical Science and Technology, Lanzhou University, 730000, Lanzhou (China); Matsuki, Takayuki, E-mail: matsuki@tokyo-kasei.ac.jp [Tokyo Kasei University, 1-18-1 Kaga, Itabashi, 173-8602, Tokyo (Japan); Theoretical Research Division, Nishina Center, RIKEN, 351-0198, Saitama (Japan)

    2015-01-27

    Newly observed two charmed-strange resonances, D{sub s1}{sup ∗}(2860) and D{sub s3}{sup ∗}(2860), are investigated by calculating their Okubo–Zweig–Iizuka-allowed strong decays, which shows that they are suitable candidates for the 1{sup 3}D{sub 1} and 1{sup 3}D{sub 3} states in the charmed-strange meson family. Our study also predicts other main decay modes of D{sub s1}{sup ∗}(2860) and D{sub s3}{sup ∗}(2860), which can be accessible at the future experiment. In addition, the decay behaviors of the spin partners of D{sub s1}{sup ∗}(2860) and D{sub s3}{sup ∗}(2860), i.e., 1D(2{sup -}) and 1D{sup ′}(2{sup -}), are predicted in this work, which are still missing at present. The experimental search for the missing 1D(2{sup -}) and 1D{sup ′}(2{sup -}) charmed-strange mesons is an intriguing and challenging task for further experiments.

  6. In Situ Thermal Generation of Silver Nanoparticles in 3D Printed Polymeric Structures

    Science.gov (United States)

    Fantino, Erika; Chiappone, Annalisa; Calignano, Flaviana; Fontana, Marco; Pirri, Fabrizio; Roppolo, Ignazio

    2016-01-01

    Polymer nanocomposites have always attracted the interest of researchers and industry because of their potential combination of properties from both the nanofillers and the hosting matrix. Gathering nanomaterials and 3D printing could offer clear advantages and numerous new opportunities in several application fields. Embedding nanofillers in a polymeric matrix could improve the final material properties but usually the printing process gets more difficult. Considering this drawback, in this paper we propose a method to obtain polymer nanocomposites by in situ generation of nanoparticles after the printing process. 3D structures were fabricated through a Digital Light Processing (DLP) system by disolving metal salts in the starting liquid formulation. The 3D fabrication is followed by a thermal treatment in order to induce in situ generation of metal nanoparticles (NPs) in the polymer matrix. Comprehensive studies were systematically performed on the thermo-mechanical characteristics, morphology and electrical properties of the 3D printed nanocomposites. PMID:28773716

  7. In Situ Thermal Generation of Silver Nanoparticles in 3D Printed Polymeric Structures

    Directory of Open Access Journals (Sweden)

    Erika Fantino

    2016-07-01

    Full Text Available Polymer nanocomposites have always attracted the interest of researchers and industry because of their potential combination of properties from both the nanofillers and the hosting matrix. Gathering nanomaterials and 3D printing could offer clear advantages and numerous new opportunities in several application fields. Embedding nanofillers in a polymeric matrix could improve the final material properties but usually the printing process gets more difficult. Considering this drawback, in this paper we propose a method to obtain polymer nanocomposites by in situ generation of nanoparticles after the printing process. 3D structures were fabricated through a Digital Light Processing (DLP system by disolving metal salts in the starting liquid formulation. The 3D fabrication is followed by a thermal treatment in order to induce in situ generation of metal nanoparticles (NPs in the polymer matrix. Comprehensive studies were systematically performed on the thermo-mechanical characteristics, morphology and electrical properties of the 3D printed nanocomposites.

  8. Study of East Kazakh explosions and propagation in Central Asia using regional Chinese seismograms

    International Nuclear Information System (INIS)

    Patton, H.J.; Mills, J.M. Jr.

    1984-03-01

    Seismograms recorded at the Urumchi Station in northwestern China from eleven Asian events including seven presumed East Kazakh nuclear explosions were analyzed. Group velocity dispersion curves of Rayleigh waves were measured at short periods on paths through basin and fold belt terrains. At 10 sec period, the velocities on paths over sedimentary basins are 25% slower than velocities on paths over fold belts. We interpret those differences in velocities to be due to the great thicknesses of sedimentary deposits in basin terrains. Epicentral locations were estimated using differential travel times between P/sub n/ and L/sub g/ and particle motions of Rayleigh waves measured on a single three-component record. For a 1000 km path, the location errors (one standad deviation) are about +-125 km in azimuth and +-30 km in distance. In addition, systematic errors due to structural effects on surface-wave paths and on velocities of regional phases are shown to seriously bias location estimates of several events. We applied a differential phase method to Rayleigh waves from the East Kazakh explosions and found that signals of all events are in-phase with signals from the reference event on 10/12/80. Thus, there is no evidence for phase reversals or shifts at the Urumchi station in the frequency band where signal to noise ratio is good and where assumptions of the method are valid. Seismic moments of explosions were estimated using models of explosion sources with associated tectonic release. Observed amplitude spectra of Rayleigh waves were richer in high frequencies than predicted by the model. This could be a source effect related to source medium excitation (i.e., Green's functions) or a path effect caused by energy focussing and/or amplifications. We discuss the potential bias in the estimates of moment due to assumptions/limitations. 24 references, 16 figures, 6 tables

  9. Measurement of D* meson with two jets in photoproduction with the H1 detector at HERA

    International Nuclear Information System (INIS)

    Staykova, Zlatka

    2011-02-01

    Photoproduction events containing a charmed meson D *± and two jets are investigated with the H1 detector using the HERA II data sample. The measurement is based on e + p collisions during the period of 2006/2007 data taking and uses integrated luminosity of 113.14 pb -1 . The kinematic range of the measurement covers 100 GeV γp 2 2 . The D * mesons are reconstructed in the decay channel, D *± →D 0 π ± →K -+ π ± π ± . Jets were reconstructed using the inclusive k t algorithm and are selected if they have transverse momenta of p t (jet)>3.5 GeV. One of the jets has to be associated with the D * meson itself, such that the parent charmed quark can be tagged. The phase space of the measurement is limited within the central rapidity for the D * meson and the D * jet , vertical stroke η vertical stroke <1.5 while the second jet was measured within, -1.5<η<2.9. Single differential cross sections and double differential distributions were measured and compared to Leading Order Monte Carlo (MC) event generators, Pythia and Cascade and with the Next-to-Leading order MC generator MC rate at NLO. (orig.)

  10. 3D conditional generative adversarial networks for high-quality PET image estimation at low dose.

    Science.gov (United States)

    Wang, Yan; Yu, Biting; Wang, Lei; Zu, Chen; Lalush, David S; Lin, Weili; Wu, Xi; Zhou, Jiliu; Shen, Dinggang; Zhou, Luping

    2018-07-01

    Positron emission tomography (PET) is a widely used imaging modality, providing insight into both the biochemical and physiological processes of human body. Usually, a full dose radioactive tracer is required to obtain high-quality PET images for clinical needs. This inevitably raises concerns about potential health hazards. On the other hand, dose reduction may cause the increased noise in the reconstructed PET images, which impacts the image quality to a certain extent. In this paper, in order to reduce the radiation exposure while maintaining the high quality of PET images, we propose a novel method based on 3D conditional generative adversarial networks (3D c-GANs) to estimate the high-quality full-dose PET images from low-dose ones. Generative adversarial networks (GANs) include a generator network and a discriminator network which are trained simultaneously with the goal of one beating the other. Similar to GANs, in the proposed 3D c-GANs, we condition the model on an input low-dose PET image and generate a corresponding output full-dose PET image. Specifically, to render the same underlying information between the low-dose and full-dose PET images, a 3D U-net-like deep architecture which can combine hierarchical features by using skip connection is designed as the generator network to synthesize the full-dose image. In order to guarantee the synthesized PET image to be close to the real one, we take into account of the estimation error loss in addition to the discriminator feedback to train the generator network. Furthermore, a concatenated 3D c-GANs based progressive refinement scheme is also proposed to further improve the quality of estimated images. Validation was done on a real human brain dataset including both the normal subjects and the subjects diagnosed as mild cognitive impairment (MCI). Experimental results show that our proposed 3D c-GANs method outperforms the benchmark methods and achieves much better performance than the state

  11. Femtosecond laser direct generation of 3D-microfluidic channels inside bulk PMMA.

    Science.gov (United States)

    Roth, Gian-Luca; Esen, Cemal; Hellmann, Ralf

    2017-07-24

    We report on laser direct generation of 3D-microchannels for microfluidic applications inside PMMA bulk material by focused femtosecond pulses. Inner lying channels with cross sectional areas from 100 µm 2 to 4400 µm 2 are directly created in the volume of a PMMA substrate. Using the presented process, the channel length is fundamentally unlimited. Here we demonstrate a channel length of 6 meters inside a substrate with dimensions of 20 × 20 × 1.1 mm. The formation of the micro channels is based on nonlinear absorption around the focal volume that triggers a material modification. The modified volume can be selectively opened to form the channel by a subsequent annealing process. The cross section of the channel is strongly influenced by the energy distribution and illumination around the focal volume determined by the optical setup and process design. The 3D channel layout can easily be realized by moving the specimen using 3D motorized stage, allowing freely chosen complex shaped channel architectures. Within a comprehensive parameter study, varying laser power, number of multi-passes, writing speed and writing depths, we identify an optimized process in terms of attainable channel height, width and aspect ratio, as well as process stability and reproducibility. The proof of concept for an application in three dimensional microfluidic systems is provided by florescence microscopy using a dye rhodamine B solution in isopropanol.

  12. Structural and functional analysis of cyclin D1 reveals p27 and substrate inhibitor binding requirements.

    Science.gov (United States)

    Liu, Shu; Bolger, Joshua K; Kirkland, Lindsay O; Premnath, Padmavathy N; McInnes, Campbell

    2010-12-17

    An alternative strategy for inhibition of the cyclin dependent kinases (CDKs) in antitumor drug discovery is afforded through the substrate recruitment site on the cyclin positive regulatory subunit. Critical CDK substrates such as the Rb and E2F families must undergo cyclin groove binding before phosphorylation, and hence inhibitors of this interaction also block substrate specific kinase activity. This approach offers the potential to generate highly selective and cell cycle specific CDK inhibitors and to reduce the inhibition of transcription mediated through CDK7 and 9, commonly observed with ATP competitive compounds. While highly potent peptide and small molecule inhibitors of CDK2/cyclin A, E substrate recruitment have been reported, little information has been generated on the determinants of inhibitor binding to the cyclin groove of the CDK4/cyclin D1 complex. CDK4/cyclin D is a validated anticancer drug target and continues to be widely pursued in the development of new therapeutics based on cell cycle blockade. We have therefore investigated the structural basis for peptide binding to its cyclin groove and have examined the features contributing to potency and selectivity of inhibitors. Peptidic inhibitors of CDK4/cyclin D of pRb phosphorylation have been synthesized, and their complexes with CDK4/cyclin D1 crystal structures have been generated. Based on available structural information, comparisons of the cyclin grooves of cyclin A2 and D1 are presented and provide insights into the determinants for peptide binding and the basis for differential binding and inhibition. In addition, a complex structure has been generated in order to model the interactions of the CDKI, p27(KIP)¹, with cyclin D1. This information has been used to shed light onto the endogenous inhibition of CDK4 and also to identify unique aspects of cyclin D1 that can be exploited in the design of cyclin groove based CDK inhibitors. Peptidic and nonpeptidic compounds have been

  13. Nickel induced re-structuring of 2D graphene to 1D graphene nanotubes: Role of radical hydrogen in catalyst assisted growth

    Science.gov (United States)

    Krishna, Rahul; Titus, Elby

    2017-12-01

    Here, we demonstrate for the first time the structural evolution of 1D graphene nanotubes (GNTs) by the cutting of two dimensional (2D) graphene oxide (GO) sheet in reducing environment at ambient conditions in presence of Ni metal in acidic environment. We observed that in-situ generated radical hydrogen (Hrad) responsible for cutting of graphene sheets and re-structuring of 2D sheet structure to one 1D nanotubes. Structural evolution of GNTs was confirmed by using of transmission electron microscopy (TEM) technique. The current vs. voltage (I-V) characteristics of GNTs displayed room temperature (RT) negative differential resistance (NDR) effect which is typical in nanowires, suggested the applicability of nanomaterial for various kind of electronics applications such as memory devices and transistors fabrication.

  14. Critique of Dilley's N/D generation of the rho resonance

    International Nuclear Information System (INIS)

    Tryon, E.P.

    1977-01-01

    Rigorous sum rules for negative moments of the discontinuity across the left-hand cut of the ππ P wave are derived and analyzed. A model by Dilley wherein the rho resonance emerges from elastic N/D equations is shown to be severely inconsistent with these sum rules. Dilley's method for selecting the input left cut is analyzed and shown to be strongly biased in favor of generating a rho. Because of this bias, together with the aforementioned violation of sum rules, Dilley's model does not comprise evidence that the rho is generated by forces in the ππ channel. Numerous successes of the quark model suggest otherwise

  15. Intramuscular Immunization of Mice with the Live-Attenuated Herpes Simplex Virus 1 Vaccine Strain VC2 Expressing Equine Herpesvirus 1 (EHV-1) Glycoprotein D Generates Anti-EHV-1 Immune Responses in Mice.

    Science.gov (United States)

    Liu, Shiliang A; Stanfield, Brent A; Chouljenko, Vladimir N; Naidu, Shan; Langohr, Ingeborg; Del Piero, Fabio; Ferracone, Jacqueline; Roy, Alma A; Kousoulas, Konstantin G

    2017-06-15

    Vaccination remains the best option to combat equine herpesvirus 1 (EHV-1) infection, and several different strategies of vaccination have been investigated and developed over the past few decades. Herein, we report that the live-attenuated herpes simplex virus 1 (HSV-1) VC2 vaccine strain, which has been shown to be unable to enter into neurons and establish latency in mice, can be utilized as a vector for the heterologous expression of EHV-1 glycoprotein D (gD) and that the intramuscular immunization of mice results in strong antiviral humoral and cellular immune responses. The VC2-EHV-1-gD recombinant virus was constructed by inserting an EHV-1 gD expression cassette under the control of the cytomegalovirus immediate early promoter into the VC2 vector in place of the HSV-1 thymidine kinase (UL23) gene. The vaccines were introduced into mice through intramuscular injection. Vaccination with both the VC2-EHV-1-gD vaccine and the commercially available vaccine Vetera EHV XP 1/4 (Vetera; Boehringer Ingelheim Vetmedica) resulted in the production of neutralizing antibodies, the levels of which were significantly higher in comparison to those in VC2- and mock-vaccinated animals ( P < 0.01 or P < 0.001). Analysis of EHV-1-reactive IgG subtypes demonstrated that vaccination with the VC2-EHV-1-gD vaccine stimulated robust IgG1 and IgG2a antibodies after three vaccinations ( P < 0.001). Interestingly, Vetera-vaccinated mice produced significantly higher levels of IgM than mice in the other groups before and after challenge ( P < 0.01 or P < 0.05). Vaccination with VC2-EHV-1-gD stimulated strong cellular immune responses, characterized by the upregulation of both interferon- and tumor necrosis factor-positive CD4 + T cells and CD8 + T cells. Overall, the data suggest that the HSV-1 VC2 vaccine strain may be used as a viral vector for the vaccination of horses as well as, potentially, for the vaccination of other economically important animals. IMPORTANCE A novel virus

  16. Standard Test Method for Measuring Neutron Fluence and Average Energy from 3H(d,n)4He Neutron Generators by Radioactivation Techniques 1

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2009-01-01

    1.1 This test method covers a general procedure for the measurement of the fast-neutron fluence rate produced by neutron generators utilizing the 3H(d,n)4He reaction. Neutrons so produced are usually referred to as 14-MeV neutrons, but range in energy depending on a number of factors. This test method does not adequately cover fusion sources where the velocity of the plasma may be an important consideration. 1.2 This test method uses threshold activation reactions to determine the average energy of the neutrons and the neutron fluence at that energy. At least three activities, chosen from an appropriate set of dosimetry reactions, are required to characterize the average energy and fluence. The required activities are typically measured by gamma ray spectroscopy. 1.3 The measurement of reaction products in their metastable states is not covered. If the metastable state decays to the ground state, the ground state reaction may be used. 1.4 The values stated in SI units are to be regarded as standard. No oth...

  17. On central ideals of finitely generated binary (-1,1)-algebras

    International Nuclear Information System (INIS)

    Pchelintsev, S V

    2002-01-01

    In 1975 the author proved that the centre of a free finitely generated (-1,1)-algebra contains a non-zero ideal of the whole algebra. Filippov proved that in a free alternative algebra of rank ≥4 there exists a trivial ideal contained in the associative centre. Il'tyakov established that the associative nucleus of a free alternative algebra of rank 3 coincides with the ideal of identities of the Cayley-Dickson algebra. In the present paper the above-mentioned theorem of the author is extended to free finitely generated binary (-1,1)-algebras. Theorem. The centre of a free finitely generated binary (-1,1)-algebra of rank ≥3 over a field of characteristic distinct from 2 and 3 contains a non-zero ideal of the whole algebra. As a by-product, we shall prove that the T-ideal generated by the function (z,x,(x,x,y)) in a free binary (-1,1)-algebra of finite rank is soluble. We deduce from this that the basis rank of the variety of binary (-1,1)-algebras is infinite

  18. Automatic Generation of 3D Building Models with Multiple Roofs

    Institute of Scientific and Technical Information of China (English)

    Kenichi Sugihara; Yoshitugu Hayashi

    2008-01-01

    Based on building footprints (building polygons) on digital maps, we are proposing the GIS and CG integrated system that automatically generates 3D building models with multiple roofs. Most building polygons' edges meet at right angles (orthogonal polygon). The integrated system partitions orthogonal building polygons into a set of rectangles and places rectangular roofs and box-shaped building bodies on these rectangles. In order to partition an orthogonal polygon, we proposed a useful polygon expression in deciding from which vertex a dividing line is drawn. In this paper, we propose a new scheme for partitioning building polygons and show the process of creating 3D roof models.

  19. Jacobson generators, Fock representations and statistics of sl(n + 1)

    International Nuclear Information System (INIS)

    Palev, T.D.; Jeugt, J. van der

    2000-10-01

    The properties of A-statistics, related to the class of simple Lie algebras sl(n + 1), n is an element of Z + (Palev, T.D.: Preprint JINR E17-10550 (1977); hep-th/9705032), are further investigated. The description of each sl(n + 1) is carried out via generators and their relations (see eq. (2.5)), first introduced by Jacobson. The related Fock spaces W p , p is an element of N, are finite-dimensional irreducible sl(n + 1)-modules. The Pauli principle of the underlying statistics is formulated. In addition the paper contains the following new results: (a) the A-statistics are interpreted as exclusion statistics; (b) within each W p operators B(p) 1 ± ,...,B(p) n ± , proportional to the Jacobson generators, are introduced. It is proved that in an appropriate topology (Definition 2) lim p→∞ B(p) i ± = B i ± , where B i ± are Bose creation and annihilation operators; (c) it is shown that the local statistics of the degenerated hard-core Bose models and of the related Heisenberg spin models is p = I A-statistics. (author)

  20. Computing K and D meson masses with N{sub f}=2+1+1 twisted mass lattice QCD

    Energy Technology Data Exchange (ETDEWEB)

    Baron, Remi [CEA, Centre de Saclay, 91 - Gif-sur-Yvette (France). IRFU/Service de Physique Nucleaire; Blossier, Benoit; Boucaud, Philippe [Paris XI Univ., 91 - Orsay (FR). Lab. de Physique Theorique] (and others)

    2010-05-15

    We discuss the computation of the mass of the K and D mesons within the framework of N{sub f}=2+1+1 twisted mass lattice QCD from a technical point of view. These quantities are essential, already at the level of generating gauge configurations, being obvious candidates to tune the strange and charm quark masses to their physical values. In particular, we address the problems related to the twisted mass flavor and parity symmetry breaking, which arise when considering a non-degenerate (c,s) doublet. We propose and verify the consistency of three methods to extract the K and D meson masses in this framework. (orig.)

  1. Genetic Characterization of Domesticated F1 Generation in Humpback Grouper (Cromileptes altivelis

    Directory of Open Access Journals (Sweden)

    Ratu Siti Aliah

    2007-01-01

    Full Text Available First generation (F1 of hatchery produced humpback grouper (Cromileptes altivelis has been characterized genetically in order to serve the information of their status in related to their breeding strategy. PCR-RFLP method was used to detect the variation of mtDNA D-loop region of F1 population at BBPBL Lampung and BBAP Situbondo. The result of study showed that reducing of haplotype diversity had been arised from broodstock (0.8548 to F1 generation population (0.7473; 0.7273; and 0.6947, respectively.  Genetic divergence that had found between population BBPBL Lampung and BBAP Situbondo make it possible to do outbreeding in order to get its heterosis's effect. Keywords: mtDNA, haplotype diversity, genetic differentiation, Cromileptes altivelis   ABSTRAK Ikan kerapu tikus (Cromileptes altivelis generasi pertama (F1 hasil domestikasi di hatchery telah dikarakterisasi secara genetik untuk menyediakan informasi status sehubungan dengan program pemuliaannya.  Metode PCR-RFLP digunakan untuk mendeteksi variasi sekuens D-loop mtDNA ikan kerapu tikus F1 yang diproduksi di BBPBL Lampung dan BBAP Situbondo.  Hasil penelitian menunjukkan bahwa telah terjadi penurunan keragaman haplotipe dari induk (0,8548 ke populasi generasi F1 (masing-masing 0,7473; 0,7273; dan 0,6947.  Adanya keragaman genetik antara populasi ikan kerapu tikus di BBPBL dan BBAP Situbondo memungkinkan dilakukannya outbreeding untuk mendapatkan efek heterosis. Kata kunci: mtDNA, keragaman haplotipe, diferensiasi genetik, Cromileptes altivelis

  2. 3D electromagnetic design and electrical characteristics analysis of a 10-MW-class hightemperature superconducting synchronous generator for wind power

    International Nuclear Information System (INIS)

    Kim, J. H.; Park, S. I.; Le, T. D.; Kim, H. M.

    2014-01-01

    In this paper, the general electromagnetic design process of a 10-MW-class high-temperature superconducting (HTS) synchronous generator that is intended to be utilized for large scale offshore wind generator is discussed. This paper presents three-dimensional (3D) electromagnetic design proposal and electrical characteristic analysis results of a 10-MW-class HTS synchronous generator for wind power. For more detailed design by reducing the errors of a two-dimensional (2D) design owing to leakage flux in air-gap, we redesign and analyze the 2D conceptual electromagnetic design model of the HTS synchronous generator using 3D finite element analysis (FEA) software. Then electrical characteristics which include the no-load and full-load voltage of generator, harmonic contents of these two load conditions, voltage regulation and losses of generator are analyzed by commercial 3D FEA software.

  3. The D-D Neutron Generator as an Alternative to Am(Li) Isotopic Neutron Source in the Active Well Coincidence Counter

    Energy Technology Data Exchange (ETDEWEB)

    McElroy, Robert Dennis [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cleveland, Steven L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-03-01

    The 235U mass assay of bulk uranium items, such as oxide canisters, fuel pellets, and fuel assemblies, is not achievable by traditional gamma-ray assay techniques due to the limited penetration of the item by the characteristic 235U gamma rays. Instead, fast neutron interrogation methods such as active neutron coincidence counting must be used. For international safeguards applications, the most commonly used active neutron systems, the Active Well Coincidence Counter (AWCC), Uranium Neutron Collar (UNCL) and 252Cf Shuffler, rely on fast neutron interrogation using an isotopic neutron source [i.e., 252Cf or Am(Li)] to achieve better measurement accuracies than are possible using gamma-ray techniques for high-mass, high-density items. However, the Am(Li) sources required for the AWCC and UNCL systems are no longer manufactured, and newly produced systems rely on limited supplies of sources salvaged from disused instruments. The 252Cf shuffler systems rely on the use of high-output 252Cf sources, which while still available have become extremely costly for use in routine operations and require replacement every five to seven years. Lack of a suitable alternative neutron interrogation source would leave a potentially significant gap in the safeguarding of uranium processing facilities. In this work, we made use of Oak Ridge National Laboratory’s (ORNL’s) Large Volume Active Well Coincidence Counter (LV-AWCC) and a commercially available deuterium-deuterium (D-D) neutron generator to examine the potential of the D-D neutron generator as an alternative to the isotopic sources. We present the performance of the LV-AWCC with D-D generator for the assay of 235U based on the results of Monte Carlo N-Particle (MCNP) simulations and measurements of depleted uranium (DU), low enriched uranium (LEU), and highly enriched uranium (HEU) items.

  4. Ph.d. report nº1

    DEFF Research Database (Denmark)

    Hernandez, Lorenzo Banos

    The following report serves as an introduction to the Ph.d subject "Control system Modeling of the Wave Star Energy's Power Take-O". The device studied belongs to the Wave Energy field, which forms part of the renewable hydro Power generation sector. In Denmark, following the succesful course...

  5. Blood flow quantification using 1D CFD parameter identification

    Science.gov (United States)

    Brosig, Richard; Kowarschik, Markus; Maday, Peter; Katouzian, Amin; Demirci, Stefanie; Navab, Nassir

    2014-03-01

    Patient-specific measurements of cerebral blood flow provide valuable diagnostic information concerning cerebrovascular diseases rather than visually driven qualitative evaluation. In this paper, we present a quantitative method to estimate blood flow parameters with high temporal resolution from digital subtraction angiography (DSA) image sequences. Using a 3D DSA dataset and a 2D+t DSA sequence, the proposed algorithm employs a 1D Computational Fluid Dynamics (CFD) model for estimation of time-dependent flow values along a cerebral vessel, combined with an additional Advection Diffusion Equation (ADE) for contrast agent propagation. The CFD system, followed by the ADE, is solved with a finite volume approximation, which ensures the conservation of mass. Instead of defining a new imaging protocol to obtain relevant data, our cost function optimizes the bolus arrival time (BAT) of the contrast agent in 2D+t DSA sequences. The visual determination of BAT is common clinical practice and can be easily derived from and be compared to values, generated by a 1D-CFD simulation. Using this strategy, we ensure that our proposed method fits best to clinical practice and does not require any changes to the medical work flow. Synthetic experiments show that the recovered flow estimates match the ground truth values with less than 12% error in the mean flow rates.

  6. Reassessment of source parameters for three major earthquakes in the East African rift system from historical seismograms and bulletins

    Directory of Open Access Journals (Sweden)

    O. Kulhánek

    2000-06-01

    Full Text Available Source parameters for three majo earthquakes in the East African rift are re-computed from historical seismograms and bulletins. The main shock and the largest foreshock of the August 25, 1906 earthquake sequence in the main Ethiopian rift are re-located on the eastern shoulder of the rift segment.The magnitude of the main shock is estimated to be 6.5 (Mw from spectral analysis. The December 13, 1910 earthquake in the Rukwa rift (Western Tanzania indicated a significant strike-slip component from teleseismcs body-waveform inversion for fault mechanism and seismic moment. The January 6, 1928 earthquake in the Gregory rift (Kenya showed a multiple rupture process and unusually long duration for a size of 6.6(Mw. The May 20, 1990 earthquake in Southern Sudan, mentioned merely for the sake of comparison, is the largest of all instrumentally recorded events in the East African rift system. Despite the fact that the mode of deformation in the continental rift is predominantly of extensional nature, the three largest earthquakes known to occur in the circum-Tanzanian craton have shallow focal depths and significant strike-slip component in their fault mechanisms. This and similar works will enrich the database for seismic hazard assessment in East Africa.

  7. Detailed seismic velocity structure of the ultra-slow spread crust at the Mid-Cayman Spreading Center from travel-time tomography and synthetic seismograms

    Science.gov (United States)

    Harding, J.; Van Avendonk, H. J.; Hayman, N. W.; Grevemeyer, I.; Peirce, C.

    2017-12-01

    The Mid-Cayman Spreading Center (MCSC), an ultraslow-spreading center in the Caribbean Sea, has formed highly variable oceanic crust. Seafloor dredges have recovered extrusive basalts in the axial deeps as well as gabbro on bathymetric highs and exhumed mantle peridotite along the only 110 km MCSC. Wide-angle refraction data were collected with active-source ocean bottom seismometers in April, 2015, along lines parallel and across the MCSC. Travel-time tomography produces relatively smooth 2-D tomographic models of compressional wave velocity. These velocity models reveal large along- and across-axis variations in seismic velocity, indicating possible changes in crustal thickness, composition, faulting, and magmatism. It is difficult, however, to differentiate between competing interpretations of seismic velocity using these tomographic models alone. For example, in some areas the seismic velocities may be explained by either thin igneous crust or exhumed, serpentinized mantle. Distinguishing between these two interpretations is important as we explore the relationships between magmatism, faulting, and hydrothermal venting at ultraslow-spreading centers. We therefore improved our constraints on the shallow seismic velocity structure of the MCSC by modeling the amplitude of seismic refractions in the wide-angle data set. Synthetic seismograms were calculated with a finite-difference method for a range of models with different vertical velocity gradients. Small-scale features in the velocity models, such as steep velocity gradients and Moho boundaries, were explored systematically to best fit the real data. With this approach, we have improved our understanding of the compressional velocity structure of the MCSC along with the geological interpretations that are consistent with three seismic refraction profiles. Line P01 shows a variation in the thinness of lower seismic velocities along the axis, indicating two segment centers, while across-axis lines P02 and P03

  8. Droplet generation in cross-flow for cost-effective 3D-printed “plug-and-play” microfluidic devices

    KAUST Repository

    Zhang, Jiaming

    2016-08-04

    Droplet-based microfluidics is a rapidly growing field of research and involves various applications from chemistry to biology. Droplet generation techniques become the pre-requisite focus. Additive manufacturing (3D printing) technology has recently been exploited in microfluidics due to its simplicity and low cost. However, only relatively large droplets can be produced in current 3D-printed droplet generators, due to the channel dimension limitations on how fine a channel can be 3D-printed. Here we report a novel design of a 3D-printed

  9. Synthesis of 1-D ZnO nanorods and polypyrrole/1-D ZnO ...

    Indian Academy of Sciences (India)

    1-D ZnO nanorods and PPy/1-D ZnO nanocomposites were prepared by the surfactant-assisted precipitation and in situ polymerization method, respectively. The synthesized nanorods and nanocomposites were characterized by UV–Vis spectrophotometer, Fourier transform-infrared spectroscopy (FTIR), X-ray diffraction ...

  10. Spontaneous mutations in the flhD operon generate motility heterogeneity in Escherichia coli biofilm.

    Science.gov (United States)

    Horne, Shelley M; Sayler, Joseph; Scarberry, Nicholas; Schroeder, Meredith; Lynnes, Ty; Prüß, Birgit M

    2016-11-08

    , and 1:10. After 3 weeks, biofilm of the mixed cultures contained up to five times more biomass than biofilm of each of the individual strains. Mutations in the flhD operon can exert positive or negative effects on motility, depending on the site of the mutation. We believe that this is a mechanism to generate motility heterogeneity within E. coli biofilm, which may help to maintain biofilm biomass over extended periods of time.

  11. Microstates of D1D5(-P) black holes, as interacting D-branes

    Energy Technology Data Exchange (ETDEWEB)

    Morita, Takeshi, E-mail: morita.takeshi@shizuoka.ac.jp [Department of Physics, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529 (Japan); Shiba, Shotaro, E-mail: sshiba@cc.kyoto-su.ac.jp [Maskawa Institute for Science and Culture, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto 603-8555 (Japan)

    2015-07-30

    In our previous study (Morita et al., 2014 [1]), we figured out that the thermodynamics of the near extremal black p-branes can be explained as the collective motions of gravitationally interacting elementary p-branes (the p-soup proposal). We test this proposal in the near-extremal D1D5 and D1D5-P black holes and show that their thermodynamics also can be explained in a similar fashion, i.e. via the collective motions of the interacting elementary D1-branes and D5-branes (and waves). It may imply that the microscopic origins of these intersecting black branes and the black p-brane are explained in the unified picture. We also argue the relation between the p-soup proposal and the conformal field theory calculations of the D1D5(-P) black holes in superstring theory.

  12. Microstates of D1D5(-P black holes, as interacting D-branes

    Directory of Open Access Journals (Sweden)

    Takeshi Morita

    2015-07-01

    Full Text Available In our previous study (Morita et al., 2014 [1], we figured out that the thermodynamics of the near extremal black p-branes can be explained as the collective motions of gravitationally interacting elementary p-branes (the p-soup proposal. We test this proposal in the near-extremal D1D5 and D1D5-P black holes and show that their thermodynamics also can be explained in a similar fashion, i.e. via the collective motions of the interacting elementary D1-branes and D5-branes (and waves. It may imply that the microscopic origins of these intersecting black branes and the black p-brane are explained in the unified picture. We also argue the relation between the p-soup proposal and the conformal field theory calculations of the D1D5(-P black holes in superstring theory.

  13. Microstates of D1D5(-P) black holes, as interacting D-branes

    International Nuclear Information System (INIS)

    Morita, Takeshi; Shiba, Shotaro

    2015-01-01

    In our previous study (Morita et al., 2014 [1]), we figured out that the thermodynamics of the near extremal black p-branes can be explained as the collective motions of gravitationally interacting elementary p-branes (the p-soup proposal). We test this proposal in the near-extremal D1D5 and D1D5-P black holes and show that their thermodynamics also can be explained in a similar fashion, i.e. via the collective motions of the interacting elementary D1-branes and D5-branes (and waves). It may imply that the microscopic origins of these intersecting black branes and the black p-brane are explained in the unified picture. We also argue the relation between the p-soup proposal and the conformal field theory calculations of the D1D5(-P) black holes in superstring theory

  14. Data Assimilation of Lightning using 1D+3D/4D WRF Var Assimilation Schemes with Non-Linear Observation Operators

    Science.gov (United States)

    Navon, M. I.; Stefanescu, R.; Fuelberg, H. E.; Marchand, M.

    2012-12-01

    NASA's launch of the GOES-R Lightning Mapper (GLM) in 2015 will provide continuous, full disc, high resolution total lightning (IC + CG) data. The data will be available at a horizontal resolution of approximately 9 km. Compared to other types of data, the assimilation of lightning data into operational numerical models has received relatively little attention. Previous efforts of lightning assimilation mostly have employed nudging. This paper will describe the implementation of 1D+3D/4D Var assimilation schemes of existing ground-based WTLN (Worldwide Total Lightning Network) lightning observations using non-linear observation operators in the incremental WRFDA system. To mimic the expected output of GLM, the WTLN data were used to generate lightning super-observations characterized by flash rates/81 km2/20 min. A major difficulty associated with variational approaches is the complexity of the observation operator that defines the model equivalent of lightning. We use Convective Available Potential Energy (CAPE) as a proxy between lightning data and model variables. This operator is highly nonlinear. Marecal and Mahfouf (2003) have shown that nonlinearities can prevent direct assimilation of rainfall rates in the ECMWF 4D-VAR (using the incremental formulation proposed by Courtier et al. (1994)) from being successful. Using data from the 2011 Tuscaloosa, AL tornado outbreak, we have proved that the direct assimilation of lightning data into the WRF 3D/4D - Var systems is limited due to this incremental approach. Severe threshold limits must be imposed on the innovation vectors to obtain an improved analysis. We have implemented 1D+3D/4D Var schemes to assimilate lightning observations into the WRF model. Their use avoids innovation vector constrains from preventing the inclusion of a greater number of lightning observations Their use also minimizes the problem that nonlinearities in the moist convective scheme can introduce discontinuities in the cost function

  15. New limits on generation-1 leptoquarks

    International Nuclear Information System (INIS)

    Moulding, S.M.

    1992-11-01

    With the turn-on of HERA there is currently considerable interest in the properties of first-generation leptoquarks. In this paper we present new results of a search for these particles at CDF. Our findings are based on an analysis of 4.1 pb -1 of data collected at √s = 1.8 TeV during the 1988--89 Tevatron run. The leptoquarks are assumed to decay rapidly to first-generation leptons and quarks. We search for an excess of events containing two high energy electrons and two jets and find no events in our signal region. Events outside the signal region are consistent with Z 0 +dijet production. Based on this, and assuming BR(LQ 1 → e + q) = 100 %, we exclude first-generation leptoquarks with masses M(LQ 1 ) 1 → e + q) = 50 %, we exclude M(LQ 1 ) < 82 GeV

  16. Flood hazard assessment using 1D and 2D approaches

    Science.gov (United States)

    Petaccia, Gabriella; Costabile, Pierfranco; Macchione, Francesco; Natale, Luigi

    2013-04-01

    The EU flood risk Directive (Directive 2007/60/EC) prescribes risk assessment and mapping to develop flood risk management plans. Flood hazard mapping may be carried out with mathematical models able to determine flood-prone areas once realistic conditions (in terms of discharge or water levels) are imposed at the boundaries of the case study. The deterministic models are mainly based on shallow water equations expressed in their 1D or 2D formulation. The 1D approach is widely used, especially in technical studies, due to its relative simplicity, its computational efficiency and also because it requires topographical data not as expensive as the ones needed by 2D models. Even if in a great number of practical situations, such as modeling in-channel flows and not too wide floodplains, the 1D approach may provide results close to the prediction of a more sophisticated 2D model, it must be pointed out that the correct use of a 1D model in practical situations is more complex than it may seem. The main issues to be correctly modeled in a 1D approach are the definition of hydraulic structures such as bridges and buildings interacting with the flow and the treatment of the tributaries. Clearly all these aspects have to be taken into account also in the 2D modeling, but with fewer difficulties. The purpose of this paper is to show how the above cited issues can be described using a 1D or 2D unsteady flow modeling. In particular the Authors will show the devices that have to be implemented in 1D modeling to get reliable predictions of water levels and discharges comparable to the ones obtained using a 2D model. Attention will be focused on an actual river (Crati river) located in the South of Italy. This case study is quite complicated since it deals with the simulation of channeled flows, overbank flows, interactions with buildings, bridges and tributaries. Accurate techniques, intentionally developed by the Authors to take into account all these peculiarities in 1D and 2

  17. Neutron generators and their uses in research and applied fields. Vol. 1

    Energy Technology Data Exchange (ETDEWEB)

    Asfour, F I [Division of Basic Nuclear Sciences, Nuclear Research Center, Atomic Energy Authority, Cairo (Egypt)

    1996-03-01

    The development of the low voltage neutron generators (NGS) has contributed considerably to the scope of nuclear research and the economical application of nuclear methods. Such simple instruments are used to produce 14 MeV and 3 MeV neutrons via the 3{sup H}(d,n)4{sup H}e and 2{sup H}(d,n)3{sup H}e reactions,respectively. The neutrons are very widely used and are inexpensive, easy to install and operate, therefore, in addition to nuclear physicists, there are a number of groups of scientists who use low voltage accelerators as tools for pure and applied research, service and education. The aim of this work is to review shortly those problems and methods of science and technology where the neutrons produced in the D-T and D-D reactions play the main role. A wide range of experiments with the detection of neutrons and charged particles is available including the study of shielding and the generator technology itself. N.G. are recently widely used for the determination of neutron data needed for fast reactor and thermonuclear devices. The principles and techniques of the possible uses of neutron generators in technology and research are summarized. The review is devoted to:- Give a short review of the most important operational characteristics of the neutron generators and the necessary instruments needed for application. Outline the main applications of the neutron generators in neutron activation and prompt radiation analysis in various fields(metallurgy, chemistry, biology, meteoritic and lunar studies, geology and mining, etc...) fast neutron therapy, and radiation effects. 2 figs.

  18. Unidirectional high fiber content composites: Automatic 3D FE model generation and damage simulation

    DEFF Research Database (Denmark)

    Qing, Hai; Mishnaevsky, Leon

    2009-01-01

    A new method and a software code for the automatic generation of 3D micromechanical FE models of unidirectional long-fiber-reinforced composite (LFRC) with high fiber volume fraction with random fiber arrangement are presented. The fiber arrangement in the cross-section is generated through random...

  19. Collision free path generation in 3D with turning and pitch radius constraints for aerial vehicles

    DEFF Research Database (Denmark)

    Schøler, F.; La Cour-Harbo, A.; Bisgaard, M.

    2009-01-01

    In this paper we consider the problem of trajectory generation in 3D for uninhabited aerial systems (UAS). The proposed algorithm for trajectory generation allows us to find a feasible collision-free 3D trajectory through a number of waypoints in an environment containing obstacles. Our approach...... assumes that most of the aircraft structural and dynamic limitations can be formulated as a turn radius constraint, and that any two consecutive waypoints have line-of-sight. The generated trajectories are collision free and also satisfy a constraint on the minimum admissible turning radius, while...

  20. Molecular basis for the regulation of hypoxia-inducible factor-1α levels by 2-deoxy-D-ribose.

    Science.gov (United States)

    Ikeda, Ryuji; Tabata, Sho; Tajitsu, Yusuke; Nishizawa, Yukihiko; Minami, Kentaro; Furukawa, Tatsuhiko; Yamamoto, Masatatsu; Shinsato, Yoshinari; Akiyama, Shin-Ichi; Yamada, Katsushi; Takeda, Yasuo

    2013-09-01

    The angiogenic factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP), stimulates the chemotaxis of endothelial cells and confers resistance to apoptosis induced by hypoxia. 2-Deoxy-D-ribose, a degradation product of thymidine generated by TP enzymatic activity, inhibits the upregulation of hypoxia-inducible factor (HIF) 1α, BNIP3 and caspase-3 induced by hypoxia. In the present study, we investigated the molecular basis for the suppressive effect of 2-deoxy-D-ribose on the upregulation of HIF-1α. 2-Deoxy-D-ribose enhanced the interaction of HIF-1α and the von Hippel-Lindau (VHL) protein under hypoxic conditions. It did not affect the expression of HIF-1α, prolyl hydroxylase (PHD)1/2/3 and VHL mRNA under normoxic or hypoxic conditions, but enhanced the interaction of HIF-1α and PHD2 under hypoxic conditions. 2-Deoxy-D-ribose also increased the amount of hydroxy-HIF-1α in the presence of the proteasome inhibitor MG-132. The expression levels of TP are elevated in many types of malignant solid tumors and, thus, 2-deoxy-D-ribose generated by TP in these tumors may play an important role in tumor progression by preventing hypoxia-induced apoptosis.

  1. The correct Q1D electrodynamical part of a model for the fluid flow in a faraday segmented magnetohydrodynamic generator channel

    International Nuclear Information System (INIS)

    Bajovic, V.S.

    1995-01-01

    A Faraday ideally segmented (the absence of the Hall electric current I x =0) MHD generator channel, with a weakly ionized plasma as a working fluid, is considered. The magnetic field is applied along the z axis and the working fluid flows along the x axis. The stationary state of the flow and the stationary electric current are considered. The new quasi-one-dimensional (Q1D) electrodynamical part of a model is developed. The main assumption (besides j z = 0, E z = 0) taken in the whole working fluid flow, is j x = 0. It means that the bending of the electric current pattern in the working fluid, due to the nonmassive electrodes and the presence of the magnetic field, is not explicitly considered. In the frame of the assumption taken, the legitimacy regarding the equation of conservation of charges: div rvec j = 0 suggests that the straight electric current pattern in the model should be narrow. In other words, it suggests replacing of a rather complicated electric current pattern in a working fluid by an artificially straight and narrow one in the modeling, promising that it would still be possible to describe the global channel parameters - its electrical output, the influence of the shape and the size of the channel on the generator performance etc

  2. A moment-tensor catalog for intermediate magnitude earthquakes in Mexico

    Science.gov (United States)

    Rodríguez Cardozo, Félix; Hjörleifsdóttir, Vala; Martínez-Peláez, Liliana; Franco, Sara; Iglesias Mendoza, Arturo

    2016-04-01

    Located among five tectonic plates, Mexico is one of the world's most seismically active regions. The earthquake focal mechanisms provide important information on the active tectonics. A widespread technique for estimating the earthquake magnitud and focal mechanism is the inversion for the moment tensor, obtained by minimizing a misfit function that estimates the difference between synthetic and observed seismograms. An important element in the estimation of the moment tensor is an appropriate velocity model, which allows for the calculation of accurate Green's Functions so that the differences between observed and synthetics seismograms are due to the source of the earthquake rather than the velocity model. However, calculating accurate synthetic seismograms gets progressively more difficult as the magnitude of the earthquakes decreases. Large earthquakes (M>5.0) excite waves of longer periods that interact weakly with lateral heterogeneities in the crust. For these events, using 1D velocity models to compute Greens functions works well and they are well characterized by seismic moment tensors reported in global catalogs (eg. USGS fast moment tensor solutions and GCMT). The opposite occurs for small and intermediate sized events, where the relatively shorter periods excited interact strongly with lateral heterogeneities in the crust and upper mantle. To accurately model the Green's functions for the smaller events in a large heterogeneous area, requires 3D or regionalized 1D models. To obtain a rapid estimate of earthquake magnitude, the National Seismological Survey in Mexico (Servicio Sismológico Nacional, SSN) automatically calculates seismic moment tensors for events in the Mexican Territory (Franco et al., 2002; Nolasco-Carteño, 2006). However, for intermediate-magnitude and small earthquakes the signal-to-noise ratio could is low for many of the seismic stations, and without careful selection and filtering of the data, obtaining a stable focal mechanism

  3. Thionin-D4E1 chimeric protein protects plants against bacterial infections

    Science.gov (United States)

    Stover, Eddie W; Gupta, Goutam; Hao, Guixia

    2017-08-08

    The generation of a chimeric protein containing a first domain encoding either a pro-thionon or thionin, a second domain encoding D4E1 or pro-D4E1, and a third domain encoding a peptide linker located between the first domain and second domain is described. Either the first domain or the second domain is located at the amino terminal of the chimeric protein and the other domain (second domain or first domain, respectively) is located at the carboxyl terminal. The chimeric protein has antibacterial activity. Genetically altered plants and their progeny expressing a polynucleotide encoding the chimeric protein resist diseases caused by bacteria.

  4. Ion tail formation and its effect on 14-MeV neutron generation in D-3He plasmas

    International Nuclear Information System (INIS)

    Matsuura, H.; Nakao, Y.; Kudo, K.

    1992-01-01

    This paper reports on the triton distribution function in D- 3 He plasmas which is distorted from a Maxwellian owing to the presence of a 1.01-MeV birth component. The deuteron-triton reaction rate (i.e., 14-MeV neutron generation rate) in the plasma should be smaller than the values evaluated by assuming a Maxwellian triton distribution. A local Fokker-Planck calculation shows that although the degree of the decrease in 14-MeV neutron generation strongly depends on the plasma conditions and also on the energy loss mechanism, it becomes appreciable in actual burning plasmas

  5. From Enumerating to Generating: A Linear Time Algorithm for Generating 2D Lattice Paths with a Given Number of Turns

    Directory of Open Access Journals (Sweden)

    Ting Kuo

    2015-05-01

    Full Text Available We propose a linear time algorithm, called G2DLP, for generating 2D lattice L(n1, n2 paths, equivalent to two-item  multiset permutations, with a given number of turns. The usage of turn has three meanings: in the context of multiset permutations, it means that two consecutive elements of a permutation belong to two different items; in lattice path enumerations, it means that the path changes its direction, either from eastward to northward or from northward to eastward; in open shop scheduling, it means that we transfer a job from one type of machine to another. The strategy of G2DLP is divide-and-combine; the division is based on the enumeration results of a previous study and is achieved by aid of an integer partition algorithm and a multiset permutation algorithm; the combination is accomplished by a concatenation algorithm that constructs the paths we require. The advantage of G2DLP is twofold. First, it is optimal in the sense that it directly generates all feasible paths without visiting an infeasible one. Second, it can generate all paths in any specified order of turns, for example, a decreasing order or an increasing order. In practice, two applications, scheduling and cryptography, are discussed.

  6. ECRH launching scenario in FFHR-d1

    Science.gov (United States)

    Yanagihara, Kota; Kubo, Shin; Shimozuma, Takashi; Yoshimura, Yasuo; Igami, Hiroe; Takahashi, Hiromi; Tsujimura, Tohru; Makino, Ryohhei

    2016-10-01

    ECRH is promising as a principal heating system in a prototype helical reactor FFHR-d1 where the heating power of 80 MW is required to bring the plasma parameter to break even condition. To generate the plasma and bring it to ignition condition in FFHR-d1, it is effective to heat the under/over-dense plasma with normal ECRH or Electron Bernstein Wave (EBW). Normal ECRH is well established but heating via EBW need sophisticated injection control. EBW can be excited via the O(ordinary)-X(extraordinary)-B(EBW) mode conversion process by launching the ordinary wave from the low field side to plasma cut-off layer with optimum injection angle, and the range of injection angle to get high OXB mode conversion rate is called OXB mode conversion window. Since the window position can change as the plasma parameter, it is necessary to optimize the injection angle so as to aim the window in response to the plasma parameters. Candidates of antenna positions are determined by optimum injection points on the plasma facing wall calculated by the injection angle. Given such picked up area, detailed analysis using ray-tracing calculations and engineering antenna design will be performed.

  7. 2-O-α-D-glucosylglycerol phosphorylase from Bacillus selenitireducens MLS10 possessing hydrolytic activity on β-D-glucose 1-phosphate.

    Directory of Open Access Journals (Sweden)

    Takanori Nihira

    Full Text Available The glycoside hydrolase family (GH 65 is a family of inverting phosphorylases that act on α-glucosides. A GH65 protein (Bsel_2816 from Bacillus selenitireducens MLS10 exhibited inorganic phosphate (Pi-dependent hydrolysis of kojibiose at the rate of 0.43 s(-1. No carbohydrate acted as acceptor for the reverse phosphorolysis using β-D-glucose 1-phosphate (βGlc1P as donor. During the search for a suitable acceptor, we found that Bsel_2816 possessed hydrolytic activity on βGlc1P with a k cat of 2.8 s(-1; moreover, such significant hydrolytic activity on sugar 1-phosphate had not been reported for any inverting phosphorylase. The H2 (18O incorporation experiment and the anomeric analysis during the hydrolysis of βGlc1P revealed that the hydrolysis was due to the glucosyl-transferring reaction to a water molecule and not a phosphatase-type reaction. Glycerol was found to be the best acceptor to generate 2-O-α-D-glucosylglycerol (GG at the rate of 180 s(-1. Bsel_2816 phosphorolyzed GG through sequential Bi-Bi mechanism with a k cat of 95 s(-1. We propose 2-O-α-D-glucopyranosylglycerol: phosphate β-D-glucosyltransferase as the systematic name and 2-O-α-D-glucosylglycerol phosphorylase as the short name for Bsel_2816. This is the first report describing a phosphorylase that utilizes polyols, and not carbohydrates, as suitable acceptor substrates.

  8. DEM GENERATION FROM HIGH RESOLUTION SATELLITE IMAGES THROUGH A NEW 3D LEAST SQUARES MATCHING ALGORITHM

    Directory of Open Access Journals (Sweden)

    T. Kim

    2012-09-01

    Full Text Available Automated generation of digital elevation models (DEMs from high resolution satellite images (HRSIs has been an active research topic for many years. However, stereo matching of HRSIs, in particular based on image-space search, is still difficult due to occlusions and building facades within them. Object-space matching schemes, proposed to overcome these problem, often are very time consuming and critical to the dimensions of voxels. In this paper, we tried a new least square matching (LSM algorithm that works in a 3D object space. The algorithm starts with an initial height value on one location of the object space. From this 3D point, the left and right image points are projected. The true height is calculated by iterative least squares estimation based on the grey level differences between the left and right patches centred on the projected left and right points. We tested the 3D LSM to the Worldview images over 'Terrassa Sud' provided by the ISPRS WG I/4. We also compared the performance of the 3D LSM with the correlation matching based on 2D image space and the correlation matching based on 3D object space. The accuracy of the DEM from each method was analysed against the ground truth. Test results showed that 3D LSM offers more accurate DEMs over the conventional matching algorithms. Results also showed that 3D LSM is sensitive to the accuracy of initial height value to start the estimation. We combined the 3D COM and 3D LSM for accurate and robust DEM generation from HRSIs. The major contribution of this paper is that we proposed and validated that LSM can be applied to object space and that the combination of 3D correlation and 3D LSM can be a good solution for automated DEM generation from HRSIs.

  9. KNOW-BLADE task-3.3 report: Rotor blade computations with 3D vortex generators

    DEFF Research Database (Denmark)

    Johansen, J.; Sørensen, Niels N.; Reck, M.

    2005-01-01

    The present report describes the work done in work package WP3.3: Aerodynamic Accessories in 3D in the EC project KNOW-BLADE. Vortex generators (VGs) are modelled in 3D Navier-Stokes solvers and applied on the flow around an airfoil and a wind turbineblade. Three test cases have been investigated...

  10. PODAAC-DYNTO-1D1M1

    Data.gov (United States)

    National Aeronautics and Space Administration — The absolute dynamic topography data (similar to sea level but with respect to the geoid) are on monthly 1 degree grids. These data were generated to help support...

  11. Model-Based Generation of Synthetic 3D Time-Lapse Sequences of Motile Cells with Growing Filopodia

    OpenAIRE

    Sorokin , Dmitry ,; Peterlik , Igor; Ulman , Vladimír ,; Svoboda , David; Maška , Martin

    2017-01-01

    International audience; The existence of benchmark datasets is essential to objectively evaluate various image analysis methods. Nevertheless, manual annotations of fluorescence microscopy image data are very laborious and not often practicable, especially in the case of 3D+t experiments. In this work, we propose a simulation system capable of generating 3D time-lapse sequences of single motile cells with filopodial protrusions, accompanied by inherently generated ground truth. The system con...

  12. A method for generating stochastic 3D tree models with Python in Autodesk Maya

    Directory of Open Access Journals (Sweden)

    Nemanja Stojanović

    2016-12-01

    Full Text Available This paper introduces a method for generating 3D tree models using stochastic L-systems with stochastic parameters and Perlin noise. L-system is the most popular method for plant modeling and Perlin noise is extensively used for generating high detailed textures. Our approach is probabilistic. L-systems with a random choice of parameters can represent observed objects quite well and they are used for modeling and generating realistic plants. Textures and normal maps are generated with combinations of Perlin noises what make these trees completely unique. Script for generating these trees, textures and normal maps is written with Python/PyMEL/NumPy in Autodesk Maya.

  13. Variable delay generator, type GRV 1; Generateur de retards variables, type GRV 1

    Energy Technology Data Exchange (ETDEWEB)

    Caillet, C.; Chaigne, M.; Janot, P. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    This apparatus has been designed mainly for simulating the passage of a fluid circulating inside a pipe. It is assumed that no heat exchange occurs during the passage so that the temperature of the fluid is the same at the entry and at the exit. A consequence of this is that the apparatus memorizes the value of the temperature on entry and reproduces it again at the end of the passage. The memorizing is effected by means of condensers which are charged at a given moment and whose voltage across the terminals is read after a time which is proportional to the variable flow of the fluid. The object is therefore to delay a given value, whence the name of variable delay generator. In its present form the apparatus can produce delays of from 1,4 seconds to 3000 seconds and more. (authors) [French] Cet appareil a ete concu principalement pour simuler la duree de trajet d'un fluide circulant a l'interieur d'une tuyauterie. On admet qu'il n'y a aucun echange de chaleur durant le trajet de sorte que la temperature du fluide a la sortie est egale a celle qu'il avait a l'entree. Il en resulte que l'appareil met en memoire la valeur de la temperature a l'entree et la restitue a la fin de la duree du trajet. La memoire est realisee par des condensateurs qui sont charges a un instant donne et dont la tension aux bornes est lue apres un temps proportionnel au debit variable du fluide. Tout revient donc a retarder une grandeur, d'ou le nom de generateur de retards variables. Dans sa forme actuelle l'appareil permet d'obtenir des retards allant de 1,4 secondes a 3000 secondes et davantage. (auteurs)

  14. Variable delay generator, type GRV 1; Generateur de retards variables, type GRV 1

    Energy Technology Data Exchange (ETDEWEB)

    Caillet, C; Chaigne, M; Janot, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    This apparatus has been designed mainly for simulating the passage of a fluid circulating inside a pipe. It is assumed that no heat exchange occurs during the passage so that the temperature of the fluid is the same at the entry and at the exit. A consequence of this is that the apparatus memorizes the value of the temperature on entry and reproduces it again at the end of the passage. The memorizing is effected by means of condensers which are charged at a given moment and whose voltage across the terminals is read after a time which is proportional to the variable flow of the fluid. The object is therefore to delay a given value, whence the name of variable delay generator. In its present form the apparatus can produce delays of from 1,4 seconds to 3000 seconds and more. (authors) [French] Cet appareil a ete concu principalement pour simuler la duree de trajet d'un fluide circulant a l'interieur d'une tuyauterie. On admet qu'il n'y a aucun echange de chaleur durant le trajet de sorte que la temperature du fluide a la sortie est egale a celle qu'il avait a l'entree. Il en resulte que l'appareil met en memoire la valeur de la temperature a l'entree et la restitue a la fin de la duree du trajet. La memoire est realisee par des condensateurs qui sont charges a un instant donne et dont la tension aux bornes est lue apres un temps proportionnel au debit variable du fluide. Tout revient donc a retarder une grandeur, d'ou le nom de generateur de retards variables. Dans sa forme actuelle l'appareil permet d'obtenir des retards allant de 1,4 secondes a 3000 secondes et davantage. (auteurs)

  15. Monte Carlo Simulation on Compensated Neutron Porosity Logging in LWD With D-T Pulsed Neutron Generator

    International Nuclear Information System (INIS)

    Zhang Feng; Hou Shuang; Jin Xiuyun

    2010-01-01

    The process of neutron interaction induced by D-T pulsed neutron generator and 241 Am-Be source was simulated by using Monte Carlo method. It is concluded that the thermal neutron count descend exponentially as the spacing increasing. The smaller porosity was, the smaller the differences between the two sources were. When the porosity reached 40%, the ratio of thermal neutron count generated by D-T pulsed neutron source was much larger than that generated by 241 Am-Be neutron source, and its distribution range was wider. The near spacing selected was 20-30 cm, and that of far spacing was about 60-70 cm. The detection depth by using D-T pulsed neutron source was almost unchanged under condition of the same sapcing, and the sensitivity of measurement to the formation porosity decreases. The results showed that it can not only guarantee the statistic of count, but also improve detection sensitivity and depth at the same time of increasing spacing. Therefore, 241 Am-Be neutron source can be replaced by D-T neutron tube in LWD tool. (authors)

  16. Correlation between 25-hydroxyvitamin D levels and latitude in Brazilian postmenopausal women: from the Arzoxifene Generations Trial.

    Science.gov (United States)

    Arantes, H P; Kulak, C A M; Fernandes, C E; Zerbini, C; Bandeira, F; Barbosa, I C; Brenol, J C T; Russo, L A; Borba, V C; Chiang, A Y; Bilezikian, J P; Lazaretti-Castro, M

    2013-10-01

    We investigated vitamin D status in Brazilian cities located at different latitudes. Insufficiency (sunlight at some latitudes. National data from a country that spans a wide range of latitudes would help to determine to what extent latitude or other factors are responsible for vitamin D deficiency. We investigated vitamin D status in cities located at different latitudes in Brazil, a large continental country. The source is the Brazilian database from the Generations Trial (1,933 osteopenic or osteoporotic postmenopausal women (60 to 85 years old) with 25(OH)D measurements). 25(OH)D below 25 nmol/L (10 ng/mL) was an exclusion criterion. Baseline values were between fall and winter. The sites included Recife, Salvador, Rio de Janeiro, São Paulo, Curitiba, and Porto Alegre. Mean and standard deviation of 25(OH)D, age, spine and femoral neck T-score, calcium, creatinine, and alkaline phosphatase were calculated for each city. Pearson correlation was used for 25(OH)D and latitude. Insufficiency (cities near the equator, and this percentage progressively increases with more southern latitudes.

  17. Gigawatt peak power generation in a relativistic klystron amplifier driven by 1 kW seed-power

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Y. [Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900 (China); Science and Technology on High Power Microwave Laboratory, Mianyang 621900 (China); Xie, H. Q. [College of Science, Southwestern University of Science and Technology, Mianyang 621010 (China); Li, Z. H.; Zhang, Y. J.; Ma, Q. S. [Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900 (China)

    2013-11-15

    An S-band high gain relativistic klystron amplifier driven by kW-level RF power is proposed and studied experimentally. In the device, the RF lossy material is introduced to suppress higher mode excitation. An output power of 1.95 GW with a gain of 62.8 dB is obtained in the simulation. Under conditions of an input RF power of 1.38 kW, a microwave pulse with power of 1.9 GW, frequency of 2.86 GHz, and duration of 105 ns is generated in the experiment, and the corresponding gain is 61.4 dB.

  18. Gigawatt peak power generation in a relativistic klystron amplifier driven by 1 kW seed-power

    Science.gov (United States)

    Wu, Y.; Xie, H. Q.; Li, Z. H.; Zhang, Y. J.; Ma, Q. S.

    2013-11-01

    An S-band high gain relativistic klystron amplifier driven by kW-level RF power is proposed and studied experimentally. In the device, the RF lossy material is introduced to suppress higher mode excitation. An output power of 1.95 GW with a gain of 62.8 dB is obtained in the simulation. Under conditions of an input RF power of 1.38 kW, a microwave pulse with power of 1.9 GW, frequency of 2.86 GHz, and duration of 105 ns is generated in the experiment, and the corresponding gain is 61.4 dB.

  19. Mixing between the 23S1 and 13D1 Ds

    International Nuclear Information System (INIS)

    Yuan Ling; Chen Bing; Zhang Ailin

    2013-01-01

    Mixing between the 2 3 S 1 and 1 3 D 1 D s is studied within the 3 P 0 model. If mixing between these two 1 - states exists, D s1 * (2700)± and D sJ * (2860)± could be interpreted as the two orthogonal mixed states with mixing angle θ≈-80° in the case of a special β for each meson. However, in the case of a universal β for all mesons, D s1 * (2700)± could be interpreted as the mixed state of 2 3 S 1 and 1 3 D 1 with mixing angle 12° < θ < 21° but D s * J (2860) ± seems difficult to interpret as the orthogonal partner of D s1 * (2700) ± . (authors)

  20. dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres.

    Science.gov (United States)

    Chavez, Joselyn; Murillo-Maldonado, Juan Manuel; Bahena, Vanessa; Cruz, Ana Karina; Castañeda-Sortibrán, América; Rodriguez-Arnaiz, Rosario; Zurita, Mario; Valadez-Graham, Viviana

    2017-12-01

    Telomeres are important contributors to genome stability, as they prevent linear chromosome end degradation and contribute to the avoidance of telomeric fusions. An important component of the telomeres is the heterochromatin protein 1a (HP1a). Mutations in Su(var)205, the gene encoding HP1a in Drosophila, result in telomeric fusions, retrotransposon regulation loss and larger telomeres, leading to chromosome instability. Previously, it was found that several proteins physically interact with HP1a, including dXNP and dAdd1 (orthologues to the mammalian ATRX gene). In this study, we found that mutations in the genes encoding the dXNP and dAdd1 proteins affect chromosome stability, causing chromosomal aberrations, including telomeric defects, similar to those observed in Su(var)205 mutants. In somatic cells, we observed that dXNP and dAdd1 participate in the silencing of the telomeric HTT array of retrotransposons, preventing anomalous retrotransposon transcription and integration. Furthermore, the lack of dAdd1 results in the loss of HP1a from the telomeric regions without affecting other chromosomal HP1a binding sites; mutations in dxnp also affected HP1a localization but not at all telomeres, suggesting a specialized role for dAdd1 and dXNP proteins in locating HP1a at the tips of the chromosomes. These results place dAdd1 as an essential regulator of HP1a localization and function in the telomere heterochromatic domain.

  1. The organic anion transport polypeptide 1d1 (Oatp1d1) mediates hepatocellular uptake of phalloidin and microcystin into skate liver.

    Science.gov (United States)

    Meier-Abt, F; Hammann-Hänni, A; Stieger, B; Ballatori, N; Boyer, J L

    2007-02-01

    Organic anion transporting polypeptides (rodent Oatp; human OATP) mediate cellular uptake of numerous organic compounds including xenobiotic toxins into mammalian hepatocytes. In the little skate Leucoraja erinacea a liver-specific Oatp (Oatp1d1, also called sOatp) has been identified and suggested to represent an evolutionarily ancient precursor of the mammalian liver OATP1B1 (human), Oatp1b2 (rat), and OATP1B3 (human). The present study tested whether Oatp1d1 shares functional transport activity of the xenobiotic oligopeptide toxins phalloidin and microcystin with the mammalian liver Oatps/OATPs. The phalloidin analogue [(3)H]-demethylphalloin was taken up into skate hepatocytes with high affinity (Km approximately 0.4 microM), and uptake could be inhibited by phalloidin and a variety of typical Oatp/OATP substrates such as bromosulfophthalein, bile salts, estrone-3-sulfate, cyclosporine A and high concentrations of microcystin-LR (Ki approximately 150 microM). When expressed in Xenopus laevis oocytes Oatp1d1 increased uptake of demethylphalloin (Km approximately 2.2 microM) and microcystin-LR (Km approximately 27 microM) 2- to 3-fold over water-injected oocytes, whereas the alternative skate liver organic anion transporter, the dimeric Ostalpha/beta, exhibited no phalloidin and only minor microcystin-LR transport. Also, the closest mammalian Oatp1d1 orthologue, the human brain and testis OATP1C1, did not show any phalloidin transport activity. These results demonstrate that the evolutionarily ancient Oatp1d1 is able to mediate uptake of cyclic oligopeptide toxins into skate liver. The findings support the notion that Oatp1d1 is a precursor of the liver-specific mammalian Oatps/OATPs and that its transport properties are closely associated with certain forms of toxic liver injury such as for example protein phosphatase inhibition by the water-borne toxin microcystin.

  2. The organic anion transport polypeptide 1d1 (Oatp1d1) mediates hepatocellular uptake of phalloidin and microcystin into skate liver

    International Nuclear Information System (INIS)

    Meier-Abt, F.; Hammann-Haenni, A.; Stieger, B.; Ballatori, N.; Boyer, J.L.

    2007-01-01

    Organic anion transporting polypeptides (rodent Oatp; human OATP) mediate cellular uptake of numerous organic compounds including xenobiotic toxins into mammalian hepatocytes. In the little skate Leucoraja erinacea a liver-specific Oatp (Oatp1d1, also called sOatp) has been identified and suggested to represent an evolutionarily ancient precursor of the mammalian liver OATP1B1 (human), Oatp1b2 (rat), and OATP1B3 (human). The present study tested whether Oatp1d1 shares functional transport activity of the xenobiotic oligopeptide toxins phalloidin and microcystin with the mammalian liver Oatps/OATPs. The phalloidin analogue [ 3 H]-demethylphalloin was taken up into skate hepatocytes with high affinity (Km ∼ 0.4 μM), and uptake could be inhibited by phalloidin and a variety of typical Oatp/OATP substrates such as bromosulfophthalein, bile salts, estrone-3-sulfate, cyclosporine A and high concentrations of microcystin-LR (Ki ∼ 150 μM). When expressed in Xenopus laevis oocytes Oatp1d1 increased uptake of demethylphalloin (Km ∼ 2.2 μM) and microcystin-LR (Km ∼ 27 μM) 2- to 3-fold over water-injected oocytes, whereas the alternative skate liver organic anion transporter, the dimeric Ostα/β, exhibited no phalloidin and only minor microcystin-LR transport. Also, the closest mammalian Oatp1d1 orthologue, the human brain and testis OATP1C1, did not show any phalloidin transport activity. These results demonstrate that the evolutionarily ancient Oatp1d1 is able to mediate uptake of cyclic oligopeptide toxins into skate liver. The findings support the notion that Oatp1d1 is a precursor of the liver-specific mammalian Oatps/OATPs and that its transport properties are closely associated with certain forms of toxic liver injury such as for example protein phosphatase inhibition by the water-borne toxin microcystin

  3. High resolution 3D imaging of synchrotron generated microbeams

    Energy Technology Data Exchange (ETDEWEB)

    Gagliardi, Frank M., E-mail: frank.gagliardi@wbrc.org.au [Alfred Health Radiation Oncology, The Alfred, Melbourne, Victoria 3004, Australia and School of Medical Sciences, RMIT University, Bundoora, Victoria 3083 (Australia); Cornelius, Iwan [Imaging and Medical Beamline, Australian Synchrotron, Clayton, Victoria 3168, Australia and Centre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales 2500 (Australia); Blencowe, Anton [Division of Health Sciences, School of Pharmacy and Medical Sciences, The University of South Australia, Adelaide, South Australia 5000, Australia and Division of Information Technology, Engineering and the Environment, Mawson Institute, University of South Australia, Mawson Lakes, South Australia 5095 (Australia); Franich, Rick D. [School of Applied Sciences and Health Innovations Research Institute, RMIT University, Melbourne, Victoria 3000 (Australia); Geso, Moshi [School of Medical Sciences, RMIT University, Bundoora, Victoria 3083 (Australia)

    2015-12-15

    Purpose: Microbeam radiation therapy (MRT) techniques are under investigation at synchrotrons worldwide. Favourable outcomes from animal and cell culture studies have proven the efficacy of MRT. The aim of MRT researchers currently is to progress to human clinical trials in the near future. The purpose of this study was to demonstrate the high resolution and 3D imaging of synchrotron generated microbeams in PRESAGE® dosimeters using laser fluorescence confocal microscopy. Methods: Water equivalent PRESAGE® dosimeters were fabricated and irradiated with microbeams on the Imaging and Medical Beamline at the Australian Synchrotron. Microbeam arrays comprised of microbeams 25–50 μm wide with 200 or 400 μm peak-to-peak spacing were delivered as single, cross-fire, multidirectional, and interspersed arrays. Imaging of the dosimeters was performed using a NIKON A1 laser fluorescence confocal microscope. Results: The spatial fractionation of the MRT beams was clearly visible in 2D and up to 9 mm in depth. Individual microbeams were easily resolved with the full width at half maximum of microbeams measured on images with resolutions of as low as 0.09 μm/pixel. Profiles obtained demonstrated the change of the peak-to-valley dose ratio for interspersed MRT microbeam arrays and subtle variations in the sample positioning by the sample stage goniometer were measured. Conclusions: Laser fluorescence confocal microscopy of MRT irradiated PRESAGE® dosimeters has been validated in this study as a high resolution imaging tool for the independent spatial and geometrical verification of MRT beam delivery.

  4. High resolution 3D imaging of synchrotron generated microbeams

    International Nuclear Information System (INIS)

    Gagliardi, Frank M.; Cornelius, Iwan; Blencowe, Anton; Franich, Rick D.; Geso, Moshi

    2015-01-01

    Purpose: Microbeam radiation therapy (MRT) techniques are under investigation at synchrotrons worldwide. Favourable outcomes from animal and cell culture studies have proven the efficacy of MRT. The aim of MRT researchers currently is to progress to human clinical trials in the near future. The purpose of this study was to demonstrate the high resolution and 3D imaging of synchrotron generated microbeams in PRESAGE® dosimeters using laser fluorescence confocal microscopy. Methods: Water equivalent PRESAGE® dosimeters were fabricated and irradiated with microbeams on the Imaging and Medical Beamline at the Australian Synchrotron. Microbeam arrays comprised of microbeams 25–50 μm wide with 200 or 400 μm peak-to-peak spacing were delivered as single, cross-fire, multidirectional, and interspersed arrays. Imaging of the dosimeters was performed using a NIKON A1 laser fluorescence confocal microscope. Results: The spatial fractionation of the MRT beams was clearly visible in 2D and up to 9 mm in depth. Individual microbeams were easily resolved with the full width at half maximum of microbeams measured on images with resolutions of as low as 0.09 μm/pixel. Profiles obtained demonstrated the change of the peak-to-valley dose ratio for interspersed MRT microbeam arrays and subtle variations in the sample positioning by the sample stage goniometer were measured. Conclusions: Laser fluorescence confocal microscopy of MRT irradiated PRESAGE® dosimeters has been validated in this study as a high resolution imaging tool for the independent spatial and geometrical verification of MRT beam delivery

  5. Quantitative studies of the brain specific antigens GFA, 14-3-2, synaptin C1, D1, D2, D3 and D5 in jimpy mouse

    DEFF Research Database (Denmark)

    Jacque, C M; Baumann, N A; Bock, E

    1976-01-01

    Seven antigens specific to the nervous tissue were measured in both Jimpy and control mice. The D5 and the GFA protein, both components of the glia, are strongly increased in the mutant while the neuronal components 14-3-2, synaptin C1, D1, D2 and D3 are unchanged....

  6. 26 CFR 1.45D-1 - New markets tax credit.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true New markets tax credit. 1.45D-1 Section 1.45D-1... Computing Credit for Investment in Certain Depreciable Property § 1.45D-1 New markets tax credit. (a) Table... of new markets tax credit (B) Recapture event (ii) CDE reporting requirements to Secretary (iii...

  7. 3D SPH numerical simulation of the wave generated by the Vajont rockslide

    Science.gov (United States)

    Vacondio, R.; Mignosa, P.; Pagani, S.

    2013-09-01

    A 3D numerical modeling of the wave generated by the Vajont slide, one of the most destructive ever occurred, is presented in this paper. A meshless Lagrangian Smoothed Particle Hydrodynamics (SPH) technique was adopted to simulate the highly fragmented violent flow generated by the falling slide in the artificial reservoir. The speed-up achievable via General Purpose Graphic Processing Units (GP-GPU) allowed to adopt the adequate resolution to describe the phenomenon. The comparison with the data available in literature showed that the results of the numerical simulation reproduce satisfactorily the maximum run-up, also the water surface elevation in the residual lake after the event. Moreover, the 3D velocity field of the flow during the event and the discharge hydrograph which overtopped the dam, were obtained.

  8. DIII-D Integrated plasma control solutions for ITER and next-generation tokamaks

    International Nuclear Information System (INIS)

    Humphreys, D.A.; Ferron, J.R.; Hyatt, A.W.; La Haye, R.J.; Leuer, J.A.; Penaflor, B.G.; Walker, M.L.; Welander, A.S.; In, Y.

    2008-01-01

    Plasma control design approaches and solutions developed at DIII-D to address its control-intensive advanced tokamak (AT) mission are applicable to many problems facing ITER and other next-generation devices. A systematic approach to algorithm design, termed 'integrated plasma control,' enables new tokamak controllers to be applied operationally with minimal machine time required for tuning. Such high confidence plasma control algorithms are designed using relatively simple ('control-level') models validated against experimental response data and are verified in simulation prior to operational use. A key element of DIII-D integrated plasma control, also required in the ITER baseline control approach, is the ability to verify both controller performance and implementation by running simulations that connect directly to the actual plasma control system (PCS) that is used to operate the tokamak itself. The DIII-D PCS comprises a powerful and flexible C-based realtime code and programming infrastructure, as well as an arbitrarily scalable hardware and realtime network architecture. This software infrastructure provides a general platform for implementation and verification of realtime algorithms with arbitrary complexity, limited only by speed of execution requirements. We present a complete suite of tools (known collectively as TokSys) supporting the integrated plasma control design process, along with recent examples of control algorithms designed for the DIII-D PCS. The use of validated physics-based models and a systematic model-based design and verification process enables these control solutions to be directly applied to ITER and other next-generation tokamaks

  9. 26 CFR 1.860D-1 - Definition of a REMIC.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Definition of a REMIC. 1.860D-1 Section 1.860D-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.860D-1 Definition of a REMIC. (a) In general. A real...

  10. Quantum theory for 1D X-ray free electron laser

    Science.gov (United States)

    Anisimov, Petr M.

    2018-06-01

    Classical 1D X-ray Free Electron Laser (X-ray FEL) theory has stood the test of time by guiding FEL design and development prior to any full-scale analysis. Future X-ray FELs and inverse-Compton sources, where photon recoil approaches an electron energy spread value, push the classical theory to its limits of applicability. After substantial efforts by the community to find what those limits are, there is no universally agreed upon quantum approach to design and development of future X-ray sources. We offer a new approach to formulate the quantum theory for 1D X-ray FELs that has an obvious connection to the classical theory, which allows for immediate transfer of knowledge between the two regimes. We exploit this connection in order to draw quantum mechanical conclusions about the quantum nature of electrons and generated radiation in terms of FEL variables.

  11. Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle.

    Science.gov (United States)

    Treebak, Jonas T; Pehmøller, Christian; Kristensen, Jonas M; Kjøbsted, Rasmus; Birk, Jesper B; Schjerling, Peter; Richter, Erik A; Goodyear, Laurie J; Wojtaszewski, Jørgen F P

    2014-01-15

    We investigated the phosphorylation signatures of two Rab-GTPase activating proteins TBC1D1 and TBC1D4 in human skeletal muscle in response to physical exercise and physiological insulin levels induced by a carbohydrate rich meal using a paired experimental design. Eight healthy male volunteers exercised in the fasted or fed state and muscle biopsies were taken before and immediately after exercise. We identified TBC1D1/4 phospho-sites that (1) did not respond to exercise or postprandial increase in insulin (TBC1D4: S666), (2) responded to insulin only (TBC1D4: S318), (3) responded to exercise only (TBC1D1: S237, S660, S700; TBC1D4: S588, S751), and (4) responded to both insulin and exercise (TBC1D1: T596; TBC1D4: S341, T642, S704). In the insulin-stimulated leg, Akt phosphorylation of both T308 and S473 correlated significantly with multiple sites on both TBC1D1 (T596) and TBC1D4 (S318, S341, S704). Interestingly, in the exercised leg in the fasted state TBC1D1 phosphorylation (S237, T596) correlated significantly with the activity of the α2/β2/γ3 AMPK trimer, whereas TBC1D4 phosphorylation (S341, S704) correlated with the activity of the α2/β2/γ1 AMPK trimer. Our data show differential phosphorylation of TBC1D1 and TBC1D4 in response to physiological stimuli in human skeletal muscle and support the idea that Akt and AMPK are upstream kinases. TBC1D1 phosphorylation signatures were comparable between in vitro contracted mouse skeletal muscle and exercised human muscle, and we show that AMPK regulated phosphorylation of these sites in mouse muscle. Contraction and exercise elicited a different phosphorylation pattern of TBC1D4 in mouse compared with human muscle, and although different circumstances in our experimental setup may contribute to this difference, the observation exemplifies that transferring findings between species is problematic.

  12. Exercise increases TBC1D1 phosphorylation in human skeletal muscle

    Science.gov (United States)

    Jessen, Niels; An, Ding; Lihn, Aina S.; Nygren, Jonas; Hirshman, Michael F.; Thorell, Anders

    2011-01-01

    Exercise and weight loss are cornerstones in the treatment and prevention of type 2 diabetes, and both interventions function to increase insulin sensitivity and glucose uptake into skeletal muscle. Studies in rodents demonstrate that the underlying mechanism for glucose uptake in muscle involves site-specific phosphorylation of the Rab-GTPase-activating proteins AS160 (TBC1D4) and TBC1D1. Multiple kinases, including Akt and AMPK, phosphorylate TBC1D1 and AS160 on distinct residues, regulating their activity and allowing for GLUT4 translocation. In contrast to extensive rodent-based studies, the regulation of AS160 and TBC1D1 in human skeletal muscle is not well understood. In this study, we determined the effects of dietary intervention and a single bout of exercise on TBC1D1 and AS160 site-specific phosphorylation in human skeletal muscle. Ten obese (BMI 33.4 ± 2.4, M-value 4.3 ± 0.5) subjects were studied at baseline and after a 2-wk dietary intervention. Muscle biopsies were obtained from the subjects in the resting (basal) state and immediately following a 30-min exercise bout (70% V̇o2 max). Muscle lysates were analyzed for AMPK activity and Akt phosphorylation and for TBC1D1 and AS160 phosphorylation on known or putative AMPK and Akt sites as follows: AS160 Ser711 (AMPK), TBC1D1 Ser231 (AMPK), TBC1D1 Ser660 (AMPK), TBC1D1 Ser700 (AMPK), and TBC1D1 Thr590 (Akt). The diet intervention that consisted of a major shift in the macronutrient composition resulted in a 4.2 ± 0.4 kg weight loss (P < 0.001) and a significant increase in insulin sensitivity (M value 5.6 ± 0.6), but surprisingly, there was no effect on expression or phosphorylation of any of the muscle-signaling proteins. Exercise increased muscle AMPKα2 activity but did not increase Akt phosphorylation. Exercise increased phosphorylation on AS160 Ser711, TBC1D1 Ser231, and TBC1D1 Ser660 but had no effect on TBC1D1 Ser700. Exercise did not increase TBC1D1 Thr590 phosphorylation or TBC1D1/AS160 PAS

  13. Measurement of D{sup *} meson with two jets in photoproduction with the H1 detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Staykova, Zlatka

    2011-02-15

    Photoproduction events containing a charmed meson D{sup *{+-}} and two jets are investigated with the H1 detector using the HERA II data sample. The measurement is based on e{sup +}p collisions during the period of 2006/2007 data taking and uses integrated luminosity of 113.14 pb{sup -1}. The kinematic range of the measurement covers 100 GeVD{sup *} mesons are reconstructed in the decay channel, D{sup *{+-}}{yields}D{sup 0}{pi}{sup {+-}}{yields}K{sup -+}{pi}{sup {+-}}{pi}{sup {+-}}. Jets were reconstructed using the inclusive k{sub t} algorithm and are selected if they have transverse momenta of p{sub t}(jet)>3.5 GeV. One of the jets has to be associated with the D{sup *} meson itself, such that the parent charmed quark can be tagged. The phase space of the measurement is limited within the central rapidity for the D{sup *} meson and the D{sup *}{sub jet}, vertical stroke {eta} vertical stroke <1.5 while the second jet was measured within, -1.5<{eta}<2.9. Single differential cross sections and double differential distributions were measured and compared to Leading Order Monte Carlo (MC) event generators, Pythia and Cascade and with the Next-to-Leading order MC generator MC rate at NLO. (orig.)

  14. DG-AMMOS: a new tool to generate 3d conformation of small molecules using distance geometry and automated molecular mechanics optimization for in silico screening.

    Science.gov (United States)

    Lagorce, David; Pencheva, Tania; Villoutreix, Bruno O; Miteva, Maria A

    2009-11-13

    Discovery of new bioactive molecules that could enter drug discovery programs or that could serve as chemical probes is a very complex and costly endeavor. Structure-based and ligand-based in silico screening approaches are nowadays extensively used to complement experimental screening approaches in order to increase the effectiveness of the process and facilitating the screening of thousands or millions of small molecules against a biomolecular target. Both in silico screening methods require as input a suitable chemical compound collection and most often the 3D structure of the small molecules has to be generated since compounds are usually delivered in 1D SMILES, CANSMILES or in 2D SDF formats. Here, we describe the new open source program DG-AMMOS which allows the generation of the 3D conformation of small molecules using Distance Geometry and their energy minimization via Automated Molecular Mechanics Optimization. The program is validated on the Astex dataset, the ChemBridge Diversity database and on a number of small molecules with known crystal structures extracted from the Cambridge Structural Database. A comparison with the free program Balloon and the well-known commercial program Omega generating the 3D of small molecules is carried out. The results show that the new free program DG-AMMOS is a very efficient 3D structure generator engine. DG-AMMOS provides fast, automated and reliable access to the generation of 3D conformation of small molecules and facilitates the preparation of a compound collection prior to high-throughput virtual screening computations. The validation of DG-AMMOS on several different datasets proves that generated structures are generally of equal quality or sometimes better than structures obtained by other tested methods.

  15. Design, synthesis, and characterization of 0-D, 1-D, and 2-D Zinc–Adeninate coordination assemblies

    Energy Technology Data Exchange (ETDEWEB)

    An, Ji Hyun [Dept. of Chemistry Education, Seoul National University, Seoul (Korea, Republic of); Geib, Steven J. [Dept. of Chemistry, University of Pittsburgh, Pittsburgh (United States); Kim, Myung Gil [Dept. of Chemistry, Chungang University, Seoul (Korea, Republic of)

    2015-08-15

    In this study, we demonstrate the synthesis and characterization of zinc– adeninate coordination polymers with 0-D, 1-D, and 2-D structures. We describe methods for controlling the structure of these materials by applying different synthetic conditions and discuss their structural relationships. 0-D, 1-D, and 2-D zinc–adeninate coordination polymers with the same metal–adeninate coordination mode were synthesized and characterized. By controlling the temperature, a material with 0-D macrocycle or 1-D chain coordination polymer was prepared. A replacement of pyridine with bipyridine formed 2-D sheet structure by connecting 1-D chains with each other. They exhibited an interesting relationship between synthetic methods and structures. Further study of metal–adeninate coordination chemistry will render a precise control of the structure in synthesis and will open a new venue to new materials with fascinating properties.

  16. A 3.96 GHz phase-locked loop for mode-1 MB-OFDM UWB hopping carrier generation

    Energy Technology Data Exchange (ETDEWEB)

    Zheng Yongzheng; Li Weinan; Xia Lingli; Huang Yumei; Hong Zhiliang, E-mail: yumeihuang@fudan.edu.c [State Key Laboratory of ASIC and System, Fudan University, Shanghai 201203 (China)

    2009-07-15

    A fully integrated phase-locked loop (PLL) is presented for a single quadrature output frequency of 3.96 GHz. The proposed PLL can be applied to mode-1 MB-OFDM UWB hopping carrier generation. An adaptive frequency calibration loop is incorporated into the PLL. The capacitance area in the loop filter is largely reduced through a capacitor multiplier. Implemented in a CMOS process, this PLL draws 13.0 mA current from a single 1.2 V supply while occupying 0.55 mm{sup 2} die area. Measurement results show that the PLL achieves a phase noise of-70 dBc/Hz at 10 kHz offset and -113 dBc/Hz at 1 MHz offset. The integrated RMS jitter from 1 kHz to 10 MHz is 2.2 ps. The reference spur level is less than -68 dBc.

  17. A 3.96 GHz phase-locked loop for mode-1 MB-OFDM UWB hopping carrier generation

    International Nuclear Information System (INIS)

    Zheng Yongzheng; Li Weinan; Xia Lingli; Huang Yumei; Hong Zhiliang

    2009-01-01

    A fully integrated phase-locked loop (PLL) is presented for a single quadrature output frequency of 3.96 GHz. The proposed PLL can be applied to mode-1 MB-OFDM UWB hopping carrier generation. An adaptive frequency calibration loop is incorporated into the PLL. The capacitance area in the loop filter is largely reduced through a capacitor multiplier. Implemented in a CMOS process, this PLL draws 13.0 mA current from a single 1.2 V supply while occupying 0.55 mm 2 die area. Measurement results show that the PLL achieves a phase noise of-70 dBc/Hz at 10 kHz offset and -113 dBc/Hz at 1 MHz offset. The integrated RMS jitter from 1 kHz to 10 MHz is 2.2 ps. The reference spur level is less than -68 dBc.

  18. Synthesis and functional evaluation of a peptide derivative of 1-beta-D-arabinofuranosylcytosine.

    Science.gov (United States)

    Balajthy, Z; Aradi, J; Kiss, I T; Elödi, P

    1992-09-04

    We have synthesized a peptidyl prodrug derivative of 1-beta-D-arabinofuranosylcytosine (1) designed to be a selective substrate of plasmin. D-Val-Leu-Lys-ara-C (2) was obtained by coupling the protected peptide Cbz-D-Val-Leu-(N6-Cbz)Lys-OH and ara-C (1) by a water-soluble carbodiimide (EDCI), followed by the removal of the Cbz groups by using catalytic hydrogenolysis over Pd/C. The kinetic constant of hydrolysis of 2 in the presence of plasmin demonstrated effective release of 1. The amino group of 1, which is sensitive to the removal by cytidine deaminase, is protected in 2 by the formation of the amide bond resulting in a prolonged half-life of 2 in biological milieu. The antiproliferative efficiency of 2 against L1210 leukemic cells was significantly higher than that of 1. The activity of 2 was abolished in the presence of serine proteinase inhibitor, (4-amidinopheny)methanesulfonyl fluoride. These data indicate that 2 is a prodrug form of 1 in systems generating plasmin.

  19. Production of the excited charm mesons D1 and D*2 at HERA

    International Nuclear Information System (INIS)

    Verbytskyi, Andrii

    2013-02-01

    The production of the excited charm mesons D 1 , D * 2 and D + s1 in ep collisions has been measured with the ZEUS detector at Hera. The data sample taken by the ZEUS detector in the years 2003-2007, corresponding to an integrated luminosity of 373 pb -1 has been used. The masses of the neutral, charged and strange states, the widths of the neutral states, the helicity parameters of D 0 1 and D + s1 were determined and compared with other measurements and with theoretical expectations. The measured helicity parameters of the D 0 1 and D + s1 allows for some mixing of S- and D-waves in their decays to D *± π -+ and D *± K 0 respectively. The measured value of the D 0 1 helicity parameter is also consistent with a pure D-wave decay. Ratios of branching fractions of the two decay modes of the D *0 2 , D *± 2 and D + s1 states were measured and compared with previous measurements. The fractions of charm quarks hadronising into D 1 , D * 2 and D + s1 were measured and are consistent with those obtained in e + e - annihilations. The Grid computing technology has a high importance for modern High Energy Physics. This technology has been successfully used in Zeus experiment for the MC simulations and data analysis. The dedicated infrastructure has been maintained by the author since 2010. In addition to continuous support, the author has upgraded and improved the performance of the Grid MC simulations and contributed to the Zeus data preservation project.

  20. Local magnitude, duration magnitude and seismic moment of Dahshour 1992 earthquakes

    Directory of Open Access Journals (Sweden)

    M. F. Abdelwahed

    2000-06-01

    Full Text Available Local magnitudes ML have been calculated for 56 earthquakes of the Dahshour 1992 sequence using simulated records of the KEG broadband station and the estimated calibration function of the Dahshour area. These were compared with their corresponding values of duration magnitudes obtained from the analog short period seismograms of the HLW station. The local magnitudes M L and the duration magnitudes M D for this region imply a linear relation as follows: M L = 1.2988 (± 0.04 M D – 0.9032 (± 0.14. Seismic moment has also been estimated for these events using simple measurements from the time domain records. These measurements based on the simulated Wood Anderson seismograms are used for the local magnitude (ML estimation. The derived relationship between seismic moment (M 0 and magnitude (M L is: log (M 0 = 0.954 (± 0.019 M L + 17.258 (± 0.075.

  1. A 2D/1D coupling neutron transport method based on the matrix MOC and NEM methods

    International Nuclear Information System (INIS)

    Zhang, H.; Zheng, Y.; Wu, H.; Cao, L.

    2013-01-01

    A new 2D/1D coupling method based on the matrix MOC method (MMOC) and nodal expansion method (NEM) is proposed for solving the three-dimensional heterogeneous neutron transport problem. The MMOC method, used for radial two-dimensional calculation, constructs a response matrix between source and flux with only one sweep and then solves the linear system by using the restarted GMRES algorithm instead of the traditional trajectory sweeping process during within-group iteration for angular flux update. Long characteristics are generated by using the customization of commercial software AutoCAD. A one-dimensional diffusion calculation is carried out in the axial direction by employing the NEM method. The 2D and ID solutions are coupled through the transverse leakage items. The 3D CMFD method is used to ensure the global neutron balance and adjust the different convergence properties of the radial and axial solvers. A computational code is developed based on these theories. Two benchmarks are calculated to verify the coupling method and the code. It is observed that the corresponding numerical results agree well with references, which indicates that the new method is capable of solving the 3D heterogeneous neutron transport problem directly. (authors)

  2. A 2D/1D coupling neutron transport method based on the matrix MOC and NEM methods

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, H.; Zheng, Y.; Wu, H.; Cao, L. [School of Nuclear Science and Technology, Xi' an Jiaotong University, No. 28, Xianning West Road, Xi' an, Shaanxi 710049 (China)

    2013-07-01

    A new 2D/1D coupling method based on the matrix MOC method (MMOC) and nodal expansion method (NEM) is proposed for solving the three-dimensional heterogeneous neutron transport problem. The MMOC method, used for radial two-dimensional calculation, constructs a response matrix between source and flux with only one sweep and then solves the linear system by using the restarted GMRES algorithm instead of the traditional trajectory sweeping process during within-group iteration for angular flux update. Long characteristics are generated by using the customization of commercial software AutoCAD. A one-dimensional diffusion calculation is carried out in the axial direction by employing the NEM method. The 2D and ID solutions are coupled through the transverse leakage items. The 3D CMFD method is used to ensure the global neutron balance and adjust the different convergence properties of the radial and axial solvers. A computational code is developed based on these theories. Two benchmarks are calculated to verify the coupling method and the code. It is observed that the corresponding numerical results agree well with references, which indicates that the new method is capable of solving the 3D heterogeneous neutron transport problem directly. (authors)

  3. Rational design of hypoallergens applied to the major cat allergen Fel d 1.

    Science.gov (United States)

    Saarne, T; Kaiser, L; Grönlund, H; Rasool, O; Gafvelin, G; van Hage-Hamsten, M

    2005-05-01

    Allergen-specific immunotherapy is the only treatment for allergic disease providing long-lasting symptom relief. Currently, it is mainly based on the use of crude allergen extracts. The treatment may be improved by the use of genetically engineered allergens, hypoallergens, aiming at a more effective and safer therapy. The aim of this study was to provide a rational design of hypoallergen candidates for immunotherapy by using structural information and knowledge of B and T cell epitopes of an allergen. The three-dimensional structure of the major cat allergen Fel d 1 was systematically altered by duplication of selected T cell epitopes and disruption of disulphide bonds. Seven Fel d 1 derivatives were generated and screened for allergenic reactivity in comparison with recombinant Fel d 1 in competition-ELISA. The allergenicity was further evaluated in basophil activation experiments and T cell reactivity was assessed in a lymphoproliferation assay. Three out of seven Fel d 1 derivatives, with two duplicated T cell epitopes and one or two disulphide bonds disrupted, were carefully evaluated. The three derivatives displayed a strong reduction in allergenicity with 400-900 times lower IgE-binding capacity than recombinant Fel d 1. In addition, they induced a lower degree of basophil activation and similar or stronger T cell proliferation than recombinant Fel d 1. By a rational approach, we have constructed three Fel d 1 hypoallergens with reduced IgE-binding capacities and retained T cell reactivities. This strategy may be applied to any well-characterized allergen to improve immunotherapy for allergic patients.

  4. A Novel 1D Hybrid Chaotic Map-Based Image Compression and Encryption Using Compressed Sensing and Fibonacci-Lucas Transform

    Directory of Open Access Journals (Sweden)

    Tongfeng Zhang

    2016-01-01

    Full Text Available A one-dimensional (1D hybrid chaotic system is constructed by three different 1D chaotic maps in parallel-then-cascade fashion. The proposed chaotic map has larger key space and exhibits better uniform distribution property in some parametric range compared with existing 1D chaotic map. Meanwhile, with the combination of compressive sensing (CS and Fibonacci-Lucas transform (FLT, a novel image compression and encryption scheme is proposed with the advantages of the 1D hybrid chaotic map. The whole encryption procedure includes compression by compressed sensing (CS, scrambling with FLT, and diffusion after linear scaling. Bernoulli measurement matrix in CS is generated by the proposed 1D hybrid chaotic map due to its excellent uniform distribution. To enhance the security and complexity, transform kernel of FLT varies in each permutation round according to the generated chaotic sequences. Further, the key streams used in the diffusion process depend on the chaotic map as well as plain image, which could resist chosen plaintext attack (CPA. Experimental results and security analyses demonstrate the validity of our scheme in terms of high security and robustness against noise attack and cropping attack.

  5. Synthesis of 4-O-glycosylated 1,5-anhydro-D-fructose and of 1,5-anhydro-D-tagatose from a common intermediate 2,3-O-isopropylidene -D-fructose

    DEFF Research Database (Denmark)

    Agoston, Karoly; Dekany, Gyula; Lundt, Inge

    2009-01-01

    Four novel disaccharides of glycosylated 1,5-anhydro-D-ketoses have been prepared: 1,5-anhydro-4-O-b-D-glucopyranosyl-D-fructose, 1,5-anhydro-4-O-b-D-galactopyranosyl-D-fructose, 1,5-anhydro-4-O-b-D-glucopyranosyl-D-tagatose and 1,5-anhydro-4-O-b-D-galactopyranosyl-D-tagatose. The common...... intermediate, 1,5-anhydro-2,3-O-isopropylidene-b-D-fructopyranose, was prepared from D-fructose and converted into the D-tagatose derivative by oxidation followed by stereoselective reduction to the 4-epimer. The prepared anhydro-ketoses were glycosylated and deprotected to the disaccharides....

  6. Synthesis of 4-O-glycosylated 1,5-anhydro-D-fructose and of 1,5-anhydro-D-tagatose from a common intermediate 2,3-O-isopropylidene-D-fructose.

    Science.gov (United States)

    Agoston, Károly; Dékány, Gyula; Lundt, Inge

    2009-05-26

    Four novel disaccharides of glycosylated 1,5-anhydro-D-ketoses have been prepared: 1,5-anhydro-4-O-beta-D-glucopyranosyl-D-fructose, 1,5-anhydro-4-O-beta-D-galactopyranosyl-D-fructose, 1,5-anhydro-4-O-beta-D-glucopyranosyl-D-tagatose, and 1,5-anhydro-4-O-beta-D-galactopyranosyl-D-tagatose. The common intermediate, 1,5-anhydro-2,3-O-isopropylidene-beta-D-fructopyranose, was prepared from D-fructose and was converted into the D-tagatose derivative by oxidation followed by stereoselective reduction to the 4-epimer. The anhydroketoses thus prepared were glycosylated and deprotected to give the disaccharides.

  7. Automatic Generation of 3D Caricatures Based on Artistic Deformation Styles.

    Science.gov (United States)

    Clarke, Lyndsey; Chen, Min; Mora, Benjamin

    2011-06-01

    Caricatures are a form of humorous visual art, usually created by skilled artists for the intention of amusement and entertainment. In this paper, we present a novel approach for automatic generation of digital caricatures from facial photographs, which capture artistic deformation styles from hand-drawn caricatures. We introduced a pseudo stress-strain model to encode the parameters of an artistic deformation style using "virtual" physical and material properties. We have also developed a software system for performing the caricaturistic deformation in 3D which eliminates the undesirable artifacts in 2D caricaturization. We employed a Multilevel Free-Form Deformation (MFFD) technique to optimize a 3D head model reconstructed from an input facial photograph, and for controlling the caricaturistic deformation. Our results demonstrated the effectiveness and usability of the proposed approach, which allows ordinary users to apply the captured and stored deformation styles to a variety of facial photographs.

  8. Cyclin D1 expression in prostate carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, R.A.; Ravinal, R.C.; Costa, R.S.; Lima, M.S. [Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Patologia, Ribeirão Preto, SP, Brasil, Departamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Tucci, S. [Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Cirurgia e Anatomia, Divisão de Urologia, Ribeirão Preto, SP, Brasil, Divisão de Urologia, Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Muglia, V.F. [Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Medicina Interna (Centro de Ciência da Imagem), Ribeirão Preto, SP, Brasil, Departamento de Medicina Interna (Centro de Ciência da Imagem), Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Reis, R.B. Dos [Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Cirurgia e Anatomia, Divisão de Urologia, Ribeirão Preto, SP, Brasil, Divisão de Urologia, Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Silva, G.E.B. [Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Patologia, Ribeirão Preto, SP, Brasil, Departamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil)

    2014-05-09

    The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma. We assessed cyclin D1 expression by conventional immunohistochemistry in 85 patients who underwent radical prostatectomy for prostate carcinoma and 10 normal prostate tissue samples retrieved from autopsies. We measured nuclear immunostaining in the entire tumor area and based the results on the percentage of positive tumor cells. The preoperative prostate-specific antigen (PSA) level was 8.68±5.16 ng/mL (mean±SD). Cyclin D1 staining was positive (cyclin D1 expression in >5% of tumor cells) in 64 cases (75.4%) and negative (cyclin D1 expression in ≤5% of tumor cells) in 21 cases (including 15 cases with no immunostaining). Normal prostate tissues were negative for cyclin D1. Among patients with a high-grade Gleason score (≥7), 86% of patients demonstrated cyclin D1 immunostaining of >5% (P<0.05). In the crude analysis of cyclin D1 expression, the high-grade Gleason score group showed a mean expression of 39.6%, compared to 26.9% in the low-grade Gleason score group (P<0.05). Perineural invasion tended to be associated with cyclin D1 expression (P=0.07), whereas cyclin D1 expression was not associated with PSA levels or other parameters. Our results suggest that high cyclin D1 expression could be a potential marker for tumor aggressiveness.

  9. Cyclin D1 expression in prostate carcinoma

    International Nuclear Information System (INIS)

    Pereira, R.A.; Ravinal, R.C.; Costa, R.S.; Lima, M.S.; Tucci, S.; Muglia, V.F.; Reis, R.B. Dos; Silva, G.E.B.

    2014-01-01

    The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma. We assessed cyclin D1 expression by conventional immunohistochemistry in 85 patients who underwent radical prostatectomy for prostate carcinoma and 10 normal prostate tissue samples retrieved from autopsies. We measured nuclear immunostaining in the entire tumor area and based the results on the percentage of positive tumor cells. The preoperative prostate-specific antigen (PSA) level was 8.68±5.16 ng/mL (mean±SD). Cyclin D1 staining was positive (cyclin D1 expression in >5% of tumor cells) in 64 cases (75.4%) and negative (cyclin D1 expression in ≤5% of tumor cells) in 21 cases (including 15 cases with no immunostaining). Normal prostate tissues were negative for cyclin D1. Among patients with a high-grade Gleason score (≥7), 86% of patients demonstrated cyclin D1 immunostaining of >5% (P<0.05). In the crude analysis of cyclin D1 expression, the high-grade Gleason score group showed a mean expression of 39.6%, compared to 26.9% in the low-grade Gleason score group (P<0.05). Perineural invasion tended to be associated with cyclin D1 expression (P=0.07), whereas cyclin D1 expression was not associated with PSA levels or other parameters. Our results suggest that high cyclin D1 expression could be a potential marker for tumor aggressiveness

  10. Preinjector for Linac 1, SAMES generator

    CERN Multimedia

    1974-01-01

    For a description of the Linac 1 preinjector, please see first 7403070x. When the original 520 kV Cockcroft-Walton generator broke down in 1973, it was replaced by this much smaller 520 kV SAMES generator, seen here sitting on the floor of the Faraday cage.

  11. Analytic observations for the d=1+ 1 bridge site (or single-step) deposition model

    International Nuclear Information System (INIS)

    Evans, J.W.; Kang, H.C.

    1991-01-01

    Some exact results for a reversible version of the d=1+1 bridge site (or single-step) deposition model are presented. Exact steady-state properties are determined directly for finite systems with various mean slopes. These show explicitly how the asymptotic growth velocity and fluctuations are quenched as the slope approaches its maximum allowed value. Next, exact hierarchial equations for the dynamics are presented. For the special case of ''equilibrium growth,'' these are analyzed exactly at the pair-correlation level directly for an infinite system. This provided further insight into asymptotic scaling behavior. Finally, the above hierarchy is compared with one generated from a discrete form of the Kardar--Parisi--Zhang equations. Some differences are described

  12. Characterization of RbmD (glycosyltransferase in ribostamycin gene cluster) through neomycin production reconstituted from the engineered Streptomyces fradiae BS1.

    Science.gov (United States)

    Nepal, Keshav Kumar; Oh, Tae-Jin; Subba, Bimala; Yoo, Jin Cheol; Sohng, Jae Kyung

    2009-01-31

    Amino acid homology analysis predicted that rbmD, a putative glycosyltransferase from Streptomyces ribosidificus ATCC 21294, has the highest homology with neoD in neomycin biosynthesis. S. fradiae BS1, in which the production of neomycin was abolished, was generated by disruption of the neoD gene in the neomycin producer S. fradiae. The restoration of neomycin by self complementation suggested that there was no polar effect in the mutant. In addition, S. fradiae BS6 was created with complementation by rbmD in S. fradiae BS1, and secondary metabolite analysis by ESI/MS, LC/MS and MS/MS showed the restoration of neomycin production in S. fradiae BS6. These gene inactivation and complementation studies suggested that, like neoD, rbmD functions as a 2-N-acetlyglucosaminyltransferase and demonstrated the potential for the generation of novel aminoglycoside antibiotics using glycosyltransferases in vivo.

  13. An efficient hole-filling method based on depth map in 3D view generation

    Science.gov (United States)

    Liang, Haitao; Su, Xiu; Liu, Yilin; Xu, Huaiyuan; Wang, Yi; Chen, Xiaodong

    2018-01-01

    New virtual view is synthesized through depth image based rendering(DIBR) using a single color image and its associated depth map in 3D view generation. Holes are unavoidably generated in the 2D to 3D conversion process. We propose a hole-filling method based on depth map to address the problem. Firstly, we improve the process of DIBR by proposing a one-to-four (OTF) algorithm. The "z-buffer" algorithm is used to solve overlap problem. Then, based on the classical patch-based algorithm of Criminisi et al., we propose a hole-filling algorithm using the information of depth map to handle the image after DIBR. In order to improve the accuracy of the virtual image, inpainting starts from the background side. In the calculation of the priority, in addition to the confidence term and the data term, we add the depth term. In the search for the most similar patch in the source region, we define the depth similarity to improve the accuracy of searching. Experimental results show that the proposed method can effectively improve the quality of the 3D virtual view subjectively and objectively.

  14. Visualization of elastic wavefields computed with a finite difference code

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, S. [Lawrence Livermore National Lab., CA (United States); Harris, D.

    1994-11-15

    The authors have developed a finite difference elastic propagation model to simulate seismic wave propagation through geophysically complex regions. To facilitate debugging and to assist seismologists in interpreting the seismograms generated by the code, they have developed an X Windows interface that permits viewing of successive temporal snapshots of the (2D) wavefield as they are calculated. The authors present a brief video displaying the generation of seismic waves by an explosive source on a continent, which propagate to the edge of the continent then convert to two types of acoustic waves. This sample calculation was part of an effort to study the potential of offshore hydroacoustic systems to monitor seismic events occurring onshore.

  15. Comparison of experimental and theoretical integral cross sections for D+H2(v=1, j=1)→HD(v'=1, j')+H

    International Nuclear Information System (INIS)

    Kliner, D.A.V.; Adelman, D.E.; Zare, R.N.

    1991-01-01

    We have measured the nascent HD(v'=1, j') product rotational distribution from the reaction D+H 2 (v, j) in which the H 2 reagent was either thermal (v=0, j) or prepared in the level (v=1, j=1) by stimulated Raman pumping. Translationally hot D atoms were obtained by uv laser photolysis of DBr or DI. Photolysis of DBr generated D atoms with center-of-mass collision energies (E rel ) of 1.04 and 0.82 eV, which corresponded to the production of ground state Br and spin--orbit-excited Br*, respectively. The E rel values for DI photolysis were 1.38 and 0.92 eV. Quantum-state-specific detection of HD was accomplished via (2+1) resonance-enhanced multiphoton ionization and time-of-flight mass spectrometry. Vibrational excitation of the H 2 reagent results in substantial rotational excitation of the HD(v'=1) product and increases the reaction rate into v'=1 by about a factor of 4. Although the quantum-mechanical calculation of Blais et al. [Chem. Phys. Lett. 166, 11 (1990)] for the D+H 2 (v=1, j=1)→HD(v'=1, j')+H product rotational distribution at E rel =1.02 eV is in qualitative agreement with experiment, it does not quantitatively agree with the measured distribution. Specifically, the calculated distribution is too hot by 2--3 rotational quanta, and the predicted enhancement in the v'=1 rate with reagent vibrational excitation is too large by 67%±9

  16. 1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype.

    Science.gov (United States)

    Széles, Lajos; Keresztes, Gábor; Töröcsik, Dániel; Balajthy, Zoltán; Krenács, László; Póliska, Szilárd; Steinmeyer, Andreas; Zuegel, Ulrich; Pruenster, Monika; Rot, Antal; Nagy, László

    2009-02-15

    Activation of vitamin D receptor (VDR) by 1,25-dihydroxyvitamin D(3) (1,25-vitD) reprograms dendritic cells (DC) to become tolerogenic. Previous studies suggested that 1,25-vitD could inhibit the changes brought about by differentiation and maturation of DCs. Underpinning the described phenotypic and functional alterations, there must be 1,25-vitD-coordinated transcriptional events. However, this transcriptional program has not been systematically investigated, particularly not in a developmental context. Hence, it has not been explored how 1,25-vitD-regulated genes, particularly the ones bringing about the tolerogenic phenotype, are connected to differentiation. We conducted global gene expression analysis followed by comprehensive quantitative PCR validation to clarify the interrelationship between 1,25-vitD and differentiation-driven gene expression patterns in developing human monocyte-derived and blood myeloid DCs. In this study we show that 1,25-vitD regulates a large set of genes that are not affected by differentiation. Interestingly, several genes, impacted both by the ligand and by differentiation, appear to be regulated by 1,25-vitD independently of the developmental context. We have also characterized the kinetics of generation of 1,25-vitD by using three early and robustly regulated genes, the chemokine CCL22, the inhibitory receptors CD300LF and CYP24A1. We found that monocyte-derived DCs are able to turn on 1,25-vitD sensitive genes in early phases of differentiation if the precursor is present. Our data collectively suggest that exogenous or endogenously generated 1,25-vitD regulates a large set of its targets autonomously and not via inhibition of differentiation and maturation, leading to the previously characterized tolerogenic state.

  17. 26 CFR 1.678(d)-1 - Renunciation of power.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) INCOME TAXES Grantors and Others Treated As Substantial Owners § 1.678(d)-1 Renunciation of power. Section 678(a) does not apply to a power which has been renounced or disclaimed within a reasonable time... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Renunciation of power. 1.678(d)-1 Section 1.678...

  18. An Improved Nuclear Recoil Calibration in the LUX Detector Using a Pulsed D-D Neutron Generator

    Science.gov (United States)

    Huang, Dongqing

    2017-01-01

    The LUX dark matter search experiment is a 370 kg (250 kg active mass) two-_phase liquid/gas xenon time projection chamber located at the 4850 ft level of the Sanford Underground Research Facility in Lead, SD. The first absolute charge (Qy) and light (Ly) measurement performed in situ in the LUX detector with a D-D calibration technique for nuclear recoil spanning 0.7 to 74 keV and 1.1 to 74 keV respectively have been reported in. The D-D calibration has subsequently been further improved by incorporating pulsing technique, i.e. the D-D neutron production is concentrated within narrow pulses (20 us / 250 Hz) with the timing information recorded. This technique allows the suppression of accidental backgrounds in D-D neutron data and also provides increased sensitivity for the lower energy NR calibrations. I will report the improved NR absolute Qy and Ly measurements using the pulsed D-D calibration technique performed in situ in the LUX detector. Brown University, Large Underground Xenon(LUX) Collaboration.

  19. Differentiation of Forebrain and Hippocampal Dopamine 1-Class Receptors, D1R and D5R, in Spatial Learning and Memory

    Science.gov (United States)

    Sariñana, Joshua; Tonegawa, Susumu

    2017-01-01

    Activation of prefrontal cortical (PFC), striatal, and hippocampal dopamine 1-class receptors (D1R and D5R) is necessary for normal spatial information processing. Yet the precise role of the D1R versus the D5R in the aforementioned structures, and their specific contribution to the water-maze spatial learning task remains unknown. D1R- and D5R- specific in situ hybridization probes showed that forebrain restricted D1R and D5R KO mice (F-D1R/D5R KO) displayed D1R mRNA deletion in the medial (m)PFC, dorsal and ventral striatum, and the dentate gyrus (DG) of the hippocampus. D5R mRNA deletion was limited to the mPFC, the CA1 and DG hippocampal subregions. F-D1R/D5R KO mice were given water-maze training and displayed subtle spatial latency differences between genotypes and spatial memory deficits during both regular and reversal training. To differentiate forebrain D1R from D5R activation, forebrain restricted D1R KO (F-D1R KO) and D5R KO (F-D5R KO) mice were trained on the water-maze task. F-D1R KO animals exhibited escape latency deficits throughout regular and reversal training as well as spatial memory deficits during reversal training. F-D1R KO mice also showed perseverative behavior during the reversal spatial memory probe test. In contrast, F-D5R KO animals did not present observable deficits on the water-maze task. Because F-D1R KO mice showed water-maze deficits we tested the necessity of hippocampal D1R activation for spatial learning and memory. We trained DG restricted D1R KO (DG-D1R KO) mice on the water-maze task. DG-D1R KO mice did not present detectable spatial memory deficit, but did show subtle deficits during specific days of training. Our data provides evidence that forebrain D5R activation plays a unique role in spatial learning and memory in conjunction with D1R activation. Moreover, these data suggest that mPFC and striatal, but not DG D1R activation are essential for spatial learning and memory. PMID:26174222

  20. Cyclin D1, Id1 and EMT in breast cancer

    International Nuclear Information System (INIS)

    Tobin, Nicholas P; Sims, Andrew H; Lundgren, Katja L; Lehn, Sophie; Landberg, Göran

    2011-01-01

    Cyclin D1 is a well-characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown that silencing cyclin D1 increases the migratory capacity of MDA-MB-231 breast cancer cells with concomitant increase in 'inhibitor of differentiation 1' (ID1) gene expression. Id1 is known to be associated with more invasive features of cancer and with the epithelial-mesenchymal transition (EMT). Here, we sought to determine if the increase in cell motility following cyclin D1 silencing was mediated by Id1 and enhanced EMT-features. To further substantiate these findings we aimed to delineate the link between CCND1, ID1 and EMT, as well as clinical properties in primary breast cancer. Protein and gene expression of ID1, CCND1 and EMT markers were determined in MDA-MB-231 and ZR75 cells by western blot and qPCR. Cell migration and promoter occupancy were monitored by transwell and ChIP assays, respectively. Gene expression was analysed from publicly available datasets. The increase in cell migration following cyclin D1 silencing in MDA-MB-231 cells was abolished by Id1 siRNA treatment and we observed cyclin D1 occupancy of the Id1 promoter region. Moreover, ID1 and SNAI2 gene expression was increased following cyclin D1 knock-down, an effect reversed with Id1 siRNA treatment. Similar migratory and SNAI2 increases were noted for the ER-positive ZR75-1 cell line, but in an Id1-independent manner. In a meta-analysis of 1107 breast cancer samples, CCND1 low /ID1 high tumours displayed increased expression of EMT markers and were associated with reduced recurrence free survival. Finally, a greater percentage of CCND1 low /ID1 high tumours were found in the EMT-like 'claudin-low' subtype of breast cancer than in other subtypes. These results indicate that increased migration of MDA-MB-231 cells following cyclin D1 silencing can be mediated by Id

  1. RELAP5-3D Developmental Assessment: Comparison of Versions 4.2.1i and 4.1.3i

    Energy Technology Data Exchange (ETDEWEB)

    Bayless, Paul D. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-06-01

    Figures have been generated comparing the parameters used in the developmental assessment of the RELAP5-3D code using versions 4.2.1i and 4.1.3i. The figures, which are the same as those used in Volume III of the RELAP5-3D code manual, compare calculations using the semi-implicit solution scheme with available experiment data. These figures provide a quick, visual indication of how the code predictions changed between these two code versions and can be used to identify cases in which the assessment judgment may need to be changed in Volume III of the code manual. Changes to the assessment judgments made after reviewing all of the assessment cases are also provided.

  2. Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis

    Directory of Open Access Journals (Sweden)

    Maryam Mukhtar

    2017-01-01

    Full Text Available Background. The vitamin D receptor (VDR gene regulates insulin secretion from the pancreas and acts as a mediator of the immune response through vitamin D. Polymorphism in VDR causes alterations in the functioning of vitamin D, leading to type 1 diabetes (T1D predisposition. The aim of the present study was to determine VDR gene polymorphism in association with T1D in Pakistanis. Methods. The association was evaluated by selecting rs2228570 (FokΙ, rs7975232 (ApaΙ, and rs731236 (TaqΙ polymorphic sites in 102 patients and 100 controls. Genotypes were identified by DNA sequencing and PCR-RFLP. Results. The allelic and genotypic frequencies of FokΙ and ApaI were significantly associated with T1D (p0.05. CCGC, CCGG, CCTC, and CCTG haplotypes were significantly associated with disease development (p<0.05. However, CTGG haplotype was protective towards T1D (p<0.01. Conclusion. VDR polymorphisms were identified as susceptible regions for T1D development in the Pakistani population.

  3. 26 CFR 1.1402(d)-1 - Employee and wages.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Employee and wages. 1.1402(d)-1 Section 1.1402... (CONTINUED) INCOME TAXES Tax on Self-Employment Income § 1.1402(d)-1 Employee and wages. For the purpose of the tax on self-employment income, the term “employee” and the term “wages” shall have the same...

  4. DG-AMMOS: A New tool to generate 3D conformation of small molecules using Distance Geometry and Automated Molecular Mechanics Optimization for in silico Screening

    Directory of Open Access Journals (Sweden)

    Villoutreix Bruno O

    2009-11-01

    Full Text Available Abstract Background Discovery of new bioactive molecules that could enter drug discovery programs or that could serve as chemical probes is a very complex and costly endeavor. Structure-based and ligand-based in silico screening approaches are nowadays extensively used to complement experimental screening approaches in order to increase the effectiveness of the process and facilitating the screening of thousands or millions of small molecules against a biomolecular target. Both in silico screening methods require as input a suitable chemical compound collection and most often the 3D structure of the small molecules has to be generated since compounds are usually delivered in 1D SMILES, CANSMILES or in 2D SDF formats. Results Here, we describe the new open source program DG-AMMOS which allows the generation of the 3D conformation of small molecules using Distance Geometry and their energy minimization via Automated Molecular Mechanics Optimization. The program is validated on the Astex dataset, the ChemBridge Diversity database and on a number of small molecules with known crystal structures extracted from the Cambridge Structural Database. A comparison with the free program Balloon and the well-known commercial program Omega generating the 3D of small molecules is carried out. The results show that the new free program DG-AMMOS is a very efficient 3D structure generator engine. Conclusion DG-AMMOS provides fast, automated and reliable access to the generation of 3D conformation of small molecules and facilitates the preparation of a compound collection prior to high-throughput virtual screening computations. The validation of DG-AMMOS on several different datasets proves that generated structures are generally of equal quality or sometimes better than structures obtained by other tested methods.

  5. Electricity Generation with the Novel 3D Electrode from Swim Wastewater in a Dual-chamber Microbial Fuel Cell

    Directory of Open Access Journals (Sweden)

    Lai Mei-Feng

    2016-01-01

    Full Text Available The swine wastewater has the characteristics of high concentration of organic matter, suspended solids and more high ammonia nitrogen, odor, complex pollution ingredient and large emissions. Microbial fuel cells (MFC is an electrochemical and biological systems related to chemical energy into electrical energy. A two-chambered cubic microbial fuel cell was used to evaluate the effect of a novel 3D electrode which made of iron and copper on the electricity generation. The swine wastewater containing total chemical oxygen demand (TCOD 3300±300 mg/L was used as the feedstock in anode chamber, and the potassium ferricyanide was used as electron acceptor in cathode chamber. The MFC reactor was incubated with the initial pH 7.0 in a air-shaker with a temperature (ca. 35°C and 100 rpm in fed-batch mode. A fixed external resistance (R of 100 Ω was connected between the electrodes and the closed circuit potentials of the MFCs were recorded every 2 min. The results show that using iron 3D electrode has the peak electricity generation of 176 mV at the first two day and maintained the stable electricity voltage of 110 mV during the 5th to 15th days. The COD removal efficiency could reach 80%. Using copper 3D electrode only can generate the peak electricity of 33.1 mV and stable electricity of 27 mV with the COD removal efficiency of 70%.

  6. D1/D5 systems in N=4 string theories

    International Nuclear Information System (INIS)

    Gava, Edi; Hammou, Amine B.; Morales, Jose F.; Narain, Kumar S.

    2001-01-01

    We propose CFT descriptions of the D1/D5 system in a class of freely acting Z 2 orbifolds/orientifolds of type IIB theory, with sixteen unbroken supercharges. The CFTs describing D1/D5 systems involve N=(4,4) or N=(4,0) sigma models on (R 3 xS 1 xT 4 x(T 4 ) N /S N )/Z 2 , where the action of Z 2 is diagonal and its precise nature depends on the model. We also discuss D1(D5)-brane states carrying non-trivial Kaluza-Klein charges, which correspond to excitations of two-dimensional CFTs of the type (R 3 xS 1 xT 4 ) N /S N xZ 2 N . The resulting multiplicities for two-charge bound states are shown to agree with the predictions of U-duality. We raise a puzzle concerning the multiplicities of three-charge systems, which is generically present in all vacuum configurations with sixteen unbroken supercharges studied so far, including the more familiar type IIB on K3 case: the constraints put on BPS counting formulae by U-duality are apparently in contradiction with any CFT interpretation. We argue that the presence of RR backgrounds appearing in the symmetric product CFT may provide a resolution of this puzzle. Finally, we show that the whole tower of D-instanton corrections to certain 'BPS saturated couplings' in the low energy effective actions match with the corresponding one-loop threshold corrections on the dual fundamental string side

  7. Toward tsunami early warning system in Indonesia by using rapid rupture durations estimation

    International Nuclear Information System (INIS)

    Madlazim

    2012-01-01

    Indonesia has Indonesian Tsunami Early Warning System (Ina-TEWS) since 2008. The Ina-TEWS has used automatic processing on hypocenter; Mwp, Mw (mB) and Mj. If earthquake occurred in Ocean, depth 7, then Ina-TEWS announce early warning that the earthquake can generate tsunami. However, the announcement of the Ina-TEWS is still not accuracy. Purposes of this research are to estimate earthquake rupture duration of large Indonesia earthquakes that occurred in Indian Ocean, Java, Timor sea, Banda sea, Arafura sea and Pasific ocean. We analyzed at least 330 vertical seismogram recorded by IRIS-DMC network using a direct procedure for rapid assessment of earthquake tsunami potential using simple measures on P-wave vertical seismograms on the velocity records, and the likelihood that the high-frequency, apparent rupture duration, T dur . T dur can be related to the critical parameters rupture length (L), depth (z), and shear modulus (μ) while T dur may be related to wide (W), slip (D), z or μ. Our analysis shows that the rupture duration has a stronger influence to generate tsunami than Mw and depth. The rupture duration gives more information on tsunami impact, Mo/μ, depth and size than Mw and other currently used discriminants. We show more information which known from the rupture durations. The longer rupture duration, the shallower source of the earthquake. For rupture duration greater than 50 s, the depth less than 50 km, Mw greater than 7, the longer rupture length, because T dur is proportional L and greater Mo/μ. Because Mo/μ is proportional L. So, with rupture duration information can be known information of the four parameters. We also suggest that tsunami potential is not directly related to the faulting type of source and for events that have rupture duration greater than 50 s, the earthquakes generated tsunami. With available real-time seismogram data, rapid calculation, rupture duration discriminant can be completed within 4–5 min after an earthquake

  8. Industrial Processes to Reduce Generation of Hazardous Waste at DoD facilities. Phase Report. Appendix A

    Science.gov (United States)

    1985-12-01

    by CLEMCO, Pauli & helps to stress - releive the surfaces, Griffin, CAB Systems and Royce does not heal cracks in aluminum and Mechanical Systems are now...Generation of HlazardOuIs Waste at DoD Facilities- 1.S)3 Re.port 2 PERSONAL AUTHOR(S) Ia lYE OF REPOR I Jb TIME COVERED 14. DATE OF REPORT (Year...105 miles from Hill AFB on the north slope. of the Ulntah Mountains. (For military and family members and retired military and family members only

  9. The neutron production rate measurement of an indigenously developed compact D-D neutron generator

    Directory of Open Access Journals (Sweden)

    Das Basanta Kumar

    2013-01-01

    Full Text Available One electrostatic accelerator based compact neutron generator was developed. The deuterium ions generated by the ion source were accelerated by one accelerating gap after the extraction from the ion source and bombarded to a target. Two different types of targets, the drive - in titanium target and the deuteriated titanium target were used. The neutron generator was operated at the ion source discharge potential at +Ve 1 kV that generates the deuterium ion current of 200 mA at the target while accelerated through a negative potential of 80 kV in the vacuum at 1.3×10-2 Pa filled with deuterium gas. A comparative study for the neutron yield with both the targets was carried out. The neutron flux measurement was done by the bubble detectors purchased from Bubble Technology Industries. The number of bubbles formed in the detector is the direct measurement of the total energy deposited in the detector. By counting the number of bubbles the total dose was estimated. With the help of the ICRP-74 neutron flux to dose equivalent rate conversion factors and the solid angle covered by the detector, the total neutron flux was calculated. In this presentation the operation of the generator, neutron detection by bubble detector and estimation of neutron flux has been discussed.

  10. Establishment of borehole observation system and high resolution seismic studies in the western part of the main Marmara Fault in the frame of MARSite Project

    Science.gov (United States)

    Ozel, A.; Yalcinkaya, E.; Guralp, C. M.; Tunc, S.; Meral Ozel, N.

    2013-12-01

    The main objective of this study is to install a multi-parameter borehole system and surface array as close to the main Marmara Fault (MMF) in the western Marmara Sea as possible, and measure continuously the evolution of the state of the fault zone surrounding the MMF and to detect any anomaly or change which may occur before earthquakes by making use of the data from the arrays already running in the eastern part of the Marmara Sea. The multi-parameter borehole system will be composed of very wide dynamic range and stable borehole (VBB) broad band seismic sensor, and incorporate 3-D strain meter, tilt meter, and temperature and local hydrostatic pressure measuring devices. The borehole seismic station will use the latest update technologies and design ideas to record 'Earth tides' signals to the smallest magnitude -3 events. Bringing face to face the seismograms of microearthquakes recorded by borehole and surface instruments portrays quite different contents. The shorter recording duration and nearly flat frequency spectrum up to the Nyquist frequencies of borehole records are faced with longer recording duration and rapid decay of spectral amplitudes at higher frequencies of a surface seismogram. The main causative of the observed differences are near surface geology effects that mask most of the source related information the seismograms include, and that give rise to scattering, generating longer duration seismograms. In view of these circumstances, studies on microearthquakes employing surface seismograms may bring on misleading results. Particularly, the works on earthquake physics and nucleation process of earthquakes requires elaborate analysis of tiny events. It is obvious from the studies on the nucleation process of the 1999 earthquake that tens of minutes before the major rupture initiate noteworthy microearthquake activity happened. The starting point of the 1999 rupture was a site of swarm activity noticed a few decades prior the main shock

  11. Inoenue-Wigner contraction and D = 2 + 1 supergravity

    Energy Technology Data Exchange (ETDEWEB)

    Concha, P.K.; Rodriguez, E.K. [Universidad Adolfo Ibanez, Departamento de Ciencias, Facultad de Artes Liberales, Vina del Mar (Chile); Universidad Austral de Chile, Instituto de Ciencias Fisicas y Matematicas, Valdivia (Chile); Fierro, O. [Universidad Catolica de la Santisima Concepcion, Departamento de Matematica y Fisica Aplicadas, Concepcion (Chile)

    2017-01-15

    We present a generalization of the standard Inoenue-Wigner contraction by rescaling not only the generators of a Lie superalgebra but also the arbitrary constants appearing in the components of the invariant tensor. The procedure presented here allows one to obtain explicitly the Chern-Simons supergravity action of a contracted superalgebra. In particular we show that the Poincare limit can be performed to a D = 2 + 1 (p,q) AdS Chern-Simons supergravity in presence of the exotic form. We also construct a new three-dimensional (2,0) Maxwell Chern-Simons supergravity theory as a particular limit of (2,0) AdS-Lorentz supergravity theory. The generalization for N = p + q gravitinos is also considered. (orig.)

  12. DC Motor control using motor-generator set with controlled generator field

    Science.gov (United States)

    Belsterling, Charles A.; Stone, John

    1982-01-01

    A d.c. generator is connected in series opposed to the polarity of a d.c. power source supplying a d.c. drive motor. The generator is part of a motor-generator set, the motor of which is supplied from the power source connected to the motor. A generator field control means varies the field produced by at least one of the generator windings in order to change the effective voltage output. When the generator voltage is exactly equal to the d.c. voltage supply, no voltage is applied across the drive motor. As the field of the generator is reduced, the drive motor is supplied greater voltage until the full voltage of the d.c. power source is supplied when the generator has zero field applied. Additional voltage may be applied across the drive motor by reversing and increasing the reversed field on the generator. The drive motor may be reversed in direction from standstill by increasing the generator field so that a reverse voltage is applied across the d.c. motor.

  13. Global Scale Exploration Seismics: Mapping Mantle Discontinuities with Inverse Scattering Methods and Millions of Seismograms

    Science.gov (United States)

    van der Hilst, R. D.; de Hoop, M. V.; Shim, S. H.; Shang, X.; Wang, P.; Cao, Q.

    2012-04-01

    Over the past three decades, tremendous progress has been made with the mapping of mantle heterogeneity and with the understanding of these structures in terms of, for instance, the evolution of Earth's crust, continental lithosphere, and thermo-chemical mantle convection. Converted wave imaging (e.g., receiver functions) and reflection seismology (e.g. SS stacks) have helped constrain interfaces in crust and mantle; surface wave dispersion (from earthquake or ambient noise signals) characterizes wavespeed variations in continental and oceanic lithosphere, and body wave and multi-mode surface wave data have been used to map trajectories of mantle convection and delineate mantle regions of anomalous elastic properties. Collectively, these studies have revealed substantial ocean-continent differences and suggest that convective flow is strongly influenced by but permitted to cross the upper mantle transition zone. Many questions have remained unanswered, however, and further advances in understanding require more accurate depictions of Earth's heterogeneity at a wider range of length scales. To meet this challenge we need new observations—more, better, and different types of data—and methods that help us extract and interpret more information from the rapidly growing volumes of broadband data. The huge data volumes and the desire to extract more signal from them means that we have to go beyond 'business as usual' (that is, simplified theory, manual inspection of seismograms, …). Indeed, it inspires the development of automated full wave methods, both for tomographic delineation of smooth wavespeed variations and the imaging (for instance through inverse scattering) of medium contrasts. Adjoint tomography and reverse time migration, which are closely related wave equation methods, have begun to revolutionize seismic inversion of global and regional waveform data. In this presentation we will illustrate this development - and its promise - drawing from our work

  14. Vitamin D and 1,25(OH2D Regulation of T cells

    Directory of Open Access Journals (Sweden)

    Margherita T. Cantorna

    2015-04-01

    Full Text Available Vitamin D is a direct and indirect regulator of T cells. The mechanisms by which vitamin D directly regulates T cells are reviewed and new primary data on the effects of 1,25 dihydroxyvitamin D (1,25(OH2D on human invariant natural killer (iNKT cells is presented. The in vivo effects of vitamin D on murine T cells include inhibition of T cell proliferation, inhibition of IFN-γ, IL-17 and induction of IL-4. Experiments in mice demonstrate that the effectiveness of 1,25(OH2D requires NKT cells, IL-10, the IL-10R and IL-4. Comparisons of mouse and human T cells show that 1,25(OH2D inhibits IL-17 and IFN-γ, and induces T regulatory cells and IL-4. IL-4 was induced by 1,25(OH2D in mouse and human iNKT cells. Activation for 72h was required for optimal expression of the vitamin D receptor (VDR in human and mouse T and iNKT cells. In addition, T cells are potential autocrine sources of 1,25(OH2D but again only 48–72h after activation. Together the data support the late effects of vitamin D on diseases like inflammatory bowel disease and multiple sclerosis where reducing IL-17 and IFN-γ, while inducing IL-4 and IL-10, would be beneficial.

  15. 1D Nano materials 2012

    International Nuclear Information System (INIS)

    Yanqiu Zhu, Y.; Ma, R.; Whitby, R.; Acquah, S.

    2013-01-01

    We witnessed an initial hyped period and enthusiasm on carbon nano tubes in the 1990s later went through a significant expansion into nano tubes of other materials (metal di chalcogenides, boron nitride, etc.) as well as various nano wires and nano rods. While much of the hype might have gone, the research on one-dimensional (1D) nano materials has matured as one of the most active research areas within the nano science and nano technology community, flourishing with ample, exciting, and new research opportunities. Just like any other research frontier, researchers working in the 1D nano materials field are constantly striving to develop new fundamental science as well as potential applications. It remains a common belief that versatility and tunability of 1D nano materials would challenge many new rising tasks coming from our resource and energy demanding modern society. The traditional semiconductor industry has produced so many devices and systems from transistors, sensors, lasers, and LEDs to more sophisticated solar panels, which are now part of our daily lives. By down sizing the core components or parts to 1D form, one might wonder how fundamentally the dimensionality and morphology would impact the device performance, this is, as always, requiring us to fully understand the structure-property relationship in 1D nano materials. It may be equally crucial in connecting discovery-driven fundamental science to market-driven technology industry concerning potentially relevant findings derived from these novel materials. The importance of a platform that allows active researchers in this field to present their new development in a timely and efficient manner is therefore self-evident. Following the success of two early special issues devoted to 1D nano materials, this is the third one in a row organized by the same group of guest editors, attesting that such a platform has been well received by the readers

  16. Production of the excited charm mesons D1 and D*2 at HERA

    International Nuclear Information System (INIS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.

    2012-08-01

    The production of the excited charm mesons D 1 (2420) and D * 2 (2460) in ep collisions has been measured with the ZEUS detector at HERA using an integrated luminosity of 373 pb -1 . The masses of the neutral and charged states, the widths of the neutral states, and the helicity parameter of D 1 (2420) 0 were determined and compared with other measurements and with theoretical expectations. The measured helicity parameter of the D 0 1 allows for some mixing of S- and D-waves in its decay to D *± π -+ . The result is also consistent with a pure D-wave decay. Ratios of branching fractions of the two decay modes of the D * 2 (2460) 0 and D * 2 (2460) ± states were measured and compared with previous measurements. The fractions of charm quarks hadronising into D 1 and D * 2 were measured and are consistent with those obtained in e + e - annihilations.

  17. Social exploration of 1D games

    DEFF Research Database (Denmark)

    Valente, Andrea; Marchetti, Emanuela

    2013-01-01

    In this paper the apparently meaningless concept of a 1 dimensional computer game is explored, via netnography. A small number of games was designed and implemented, in close contact with online communities of players and developers, providing evidence that 1 dimension is enough to produce...... interesting gameplay, to allow for level design and even to leave room for artistic considerations on 1D rendering. General techniques to re-design classic 2D games into 1D are also emerging from this exploration....

  18. High-fidelity MCNP modeling of a D-T neutron generator for active interrogation of special nuclear material

    International Nuclear Information System (INIS)

    Katalenich, Jeff; Flaska, Marek; Pozzi, Sara A.; Hartman, Michael R.

    2011-01-01

    Fast and robust methods for interrogation of special nuclear material (SNM) are of interest to many agencies and institutions in the United States. It is well known that passive interrogation methods are typically sufficient for plutonium identification because of a relatively high neutron production rate from 240 Pu . On the other hand, identification of shielded uranium requires active methods using neutron or photon sources . Deuterium-deuterium (2.45 MeV) and deuterium-tritium (14.1 MeV) neutron-generator sources have been previously tested and proven to be relatively reliable instruments for active interrogation of nuclear materials . In addition, the newest generators of this type are small enough for applications requiring portable interrogation systems. Active interrogation techniques using high-energy neutrons are being investigated as a method to detect hidden SNM in shielded containers . Due to the thickness of some containers, penetrating radiation such as high-energy neutrons can provide a potential means of probing shielded SNM. In an effort to develop the capability to assess the signal seen from various forms of shielded nuclear materials, University of Michigan Neutron Science Laboratory's D-T neutron generator and its shielding were accurately modeled in MCNP. The generator, while operating at nominal power, produces approximately 1x10 10 neutrons/s, a source intensity which requires a large amount of shielding to minimize the dose rates around the generator. For this reason, the existing shielding completely encompasses the generator and does not include beam ports. Therefore, several MCNP simulations were performed to estimate the yield of uncollided 14.1-MeV neutrons from the generator for active interrogation experiments. Beam port diameters of 5, 10, 15, 20, and 25 cm were modeled to assess the resulting neutron fluxes. The neutron flux outside the beam ports was estimated to be approximately 2x10 4 n/cm 2 s.

  19. 1α-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines

    Science.gov (United States)

    Lagishetty, Venu; Chun, Rene F.; Liu, Nancy Q.; Lisse, Thomas S.; Adams, John S.; Hewison, Martin

    2010-01-01

    Vitamin D-insufficiency is a prevalent condition in populations throughout the world, with low serum levels of 25-hydroxyvitamin D (25OHD) linked to a variety of human health concerns including cancer, autoimmune disease and infection. Current data suggest that 25OHD action involves localized extra-renal conversion to 1,25-dihydroxyvitamin D (1,25(OH)2D) via tissue-specific expression of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (1α-hydroxylase). In cells such as macrophages, expression of 1α-hydroxylase is intimately associated with toll-like receptor (TLR) recognition of pathogens. However, this mechanism may not be exclusive to extra-renal generation of 1,25(OH)2D. To investigate the relationship between TLR-mediated pathogen recognition and vitamin D-induced antibacterial activity, intracrine responses to 25OHD metabolism were explored in vitro using the established colonic cell lines Caco-2 and Caco-2 clone BBe. Analysis of antibacterial factors such as cathelicidin (LL37) and β-defensin-4 (DEFB4) was carried out following co-treatment with TLR ligands. Data indicate that, unlike macrophages, Caco-2 and BBe colonic cell lines are unresponsive to TLR-induced 1α-hydroxylase. Alternative activators of 1α-hydroxylase such as transforming growth factor β were also ineffective at priming intracrine responses to 25OHD. Thus, in common with other barrier sites such as the skin or placenta, colonic epithelial cells may require specific factors to initiate intracrine responses to vitamin D. PMID:20152900

  20. A Novel Multi-View-Angle Range Images Generation Method for Measurement of Complicated Polyhedron in 3D Space

    Directory of Open Access Journals (Sweden)

    Deming Kong

    2017-01-01

    Full Text Available A new kind of generation method is proposed in this paper to acquire range images for complicated polyhedron in 3D space from a series of view angles. In the proposed generation method, concept of three-view drawing in mechanical cartography is introduced into the range image generation procedure. Negative and positive directions of x-, y-, and z-axes are selected as the view angles to generate the range images for complicated polyhedron in 3D space. Furthermore, a novel iterative operation of mathematical morphology is proposed to ensure that satisfactory range images can be generated for the polyhedron from all the selected view angles. Compared with the existing method based on single view angle and interpolation operation, structure features contained in surface of the complicated polyhedron can be represented more consistently with the reality by using the proposed multi-view-angle range images generation method. The proposed generation method is validated by using an experiment.

  1. Towards Rapid Generation and Visualisation of Large 3D Urban Landscapes for Mobile Device Navigation

    OpenAIRE

    Brujic-Okretic, V.; Gatzidis, C.; Liarokapis, F.; Baker, S.

    2008-01-01

    In this paper a procedural 3D modelling solution for mobile devices is presented based on scripting algorithms allowing for both the automatic and also semi-automatic creation of photorealistic quality virtual urban content. The combination of aerial images, GIS data, 2D ground maps and terrestrial photographs as input data coupled with a user-friendly customized interface permits the automatic and interactive generation of large-scale, accurate, georeferenced and fully-textured 3D virtual ci...

  2. Role of combined DWIBS/3D-CE-T1w whole-body MRI in tumor staging: Comparison with PET-CT

    International Nuclear Information System (INIS)

    Manenti, Guglielmo; Cicciò, Carmelo; Squillaci, Ettore; Strigari, Lidia; Calabria, Ferdinando; Danieli, Roberta

    2012-01-01

    Objectives: To assess the diagnostic performance of whole-body magnetic resonance imaging (WB-MRI) by diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in malignant tumor detection and the potential diagnostic advantages in generating fused DWIBS/3D-contrast enhanced T1w (3D-CE-T1w) images. Methods: 45 cancer patients underwent 18F-FDG PET-CT and WB-MRI for staging purpose. Fused DWIBS/3D-CE T1w images were generated off-line. 3D-CE-T1w, DWIBS images alone and fused with 3D-CE T1w were compared by two readers groups for detection of primary diseases and local/distant metastases. Diagnostic performance between the three WB-MRI data sets was assessed using receiver operating characteristic (ROC) curve analysis. Imaging exams and histopathological results were used as standard of references. Results: Areas under the ROC curves of DWIBS vs. 3D-CE-T1w vs. both sequences in fused fashion were 0.97, 0.978, and 1.00, respectively. The diagnostic performance in tumor detection of fused DWIBS/3D-CE-T1w images were statistically superior to DWIBS (p < 0.001) and 3D-CE-T1w (p ≤ 0.002); while the difference between DWIBS and 3D-CE-T1w did not show statistical significance difference. Detection rates of malignancy did not differ between WB-MRI with DWIBS and 18F-FDG PET-CT. Conclusion: WB-MRI with DWIBS is to be considered as alternative tool to conventional whole-body methods for tumor staging and during follow-up in cancer patients.

  3. 4D bioprinting: the next-generation technology for biofabrication enabled by stimuli-responsive materials.

    Science.gov (United States)

    Li, Yi-Chen; Zhang, Yu Shrike; Akpek, Ali; Shin, Su Ryon; Khademhosseini, Ali

    2016-12-02

    Four-dimensional (4D) bioprinting, encompassing a wide range of disciplines including bioengineering, materials science, chemistry, and computer sciences, is emerging as the next-generation biofabrication technology. By utilizing stimuli-responsive materials and advanced three-dimensional (3D) bioprinting strategies, 4D bioprinting aims to create dynamic 3D patterned biological structures that can transform their shapes or behavior under various stimuli. In this review, we highlight the potential use of various stimuli-responsive materials for 4D printing and their extension into biofabrication. We first discuss the state of the art and limitations associated with current 3D printing modalities and their transition into the inclusion of the additional time dimension. We then suggest the potential use of different stimuli-responsive biomaterials as the bioink that may achieve 4D bioprinting where transformation of fabricated biological constructs can be realized. We finally conclude with future perspectives.

  4. Operating experiences with 1 MW steam generator

    Energy Technology Data Exchange (ETDEWEB)

    Sano, A; Kanamori, A; Tsuchiya, T

    1975-07-01

    1 MW steam generator, which was planned as the first stage of steam generator development in Power Reactor and Nuclear Fuel Corp. (PNC) in Japan, is a single-unit, once-through, integrated shell and tube type with multi-helical coil tubes. It was completed in Oarai Engineering Center of PNC in March of 1971, and the various performance tests were carried out up to April, 1972. After the dismantle of the steam generator for structural inspection and material test, it was restored with some improvements. In this second 1 MW steam generator, small leak occurred twice during normal operation. After repairing the failure, the same kind of performance tests as the first steam generator were conducted in order to verify the thermal insulation effect of argon gas in downcomer zone from March to June, 1974. In this paper the above operating experiences were presented including the outline of some performance test results. (author)

  5. Differential anatomical expression of ganglioside GM1 species containing d18:1 or d20:1 sphingosine detected by MALDI Imaging Mass Spectrometry in mature rat brain

    Directory of Open Access Journals (Sweden)

    Nina eWeishaupt

    2015-12-01

    Full Text Available GM1 ganglioside plays a role in essential neuronal processes, including differentiation, survival and signaling. Yet, little is known about GM1 species with different sphingosine bases, such as the most abundant species containing 18 carbon atoms in the sphingosine chain (GM1d18:1, and the less abundant containing 20 carbon atoms (GM1d20:1. While absent in the early fetal brain, GM1d20:1 continues to increase throughout pre- and postnatal development and into old age, raising questions about the functional relevance of the GM1d18:1 to GM1d20:1 ratio. Matrix-assisted laser desorption/ionization (MALDI Imaging Mass Spectrometry is a novel technology that allows differentiation between these two GM1 species and quantification of their expression within an anatomical context. Using this technology, we find GM1d18:1/d20:1 expression ratios are highly specific to defined anatomical brain regions in adult rats. Thus, the ratio was significantly different among different thalamic nuclei and between the corpus callosum and internal capsule. Differential GM1d18:1/GM1d20:1 ratios measured in hippocampal subregions in rat brain complement previous studies conducted in mice. Across layers of the sensory cortex, opposing expression gradients were found for GM1d18:1 and GM1d20:1. Superficial layers demonstrated lower GM1d18:1 and higher GM1d20:1 signal than other layers, while in deep layers GM1d18:1 expression was relatively high and GM1d20:1 expression low. By far the highest GM1d18:1/d20:1 ratio was found in the amygdala. Differential expression of GM1 with d18:1- or d20:1-sphingosine bases in the adult rat brain suggests tight regulation of expression and points toward a distinct functional relevance for each of these GM1 species in neuronal processes.

  6. Turbofan noise generation. Volume 1: Analysis

    Science.gov (United States)

    Ventres, C. S.; Theobald, M. A.; Mark, W. D.

    1982-01-01

    Computer programs were developed which calculate the in-duct acoustic modes excited by a fan/stator stae operating at subsonic tip speed. Three noise source mechanisms are included: (1) sound generated by the rotor blades interacting with turbulence ingested into, or generated within, the inlet duct; (2) sound generated by the stator vanes interacting with the turbulent wakes of the rotors blades; and (3) sound generated by the stator vanes interacting with the mean velocity deficit wakes of the rotor blades. The fan/stator stage is modeled as an ensemble of blades and vanes of zero camber and thickness enclosed within an infinite hard-walled annular duct. Turbulence drawn into or generated within the inlet duct is modeled as nonhomogeneous and anisotropic random fluid motion, superimposed upon a uniform axial mean flow, and convected with that flow. Equations for the duct mode amplitudes, or expected values of the amplitudes, are derived.

  7. Test-retest measurements of dopamine D_1-type receptors using simultaneous PET/MRI imaging

    International Nuclear Information System (INIS)

    Kaller, Simon; Patt, Marianne; Becker, Georg-Alexander; Luthardt, Julia; Meyer, Philipp M.; Werner, Peter; Barthel, Henryk; Bresch, Anke; Sabri, Osama; Rullmann, Michael; Girbardt, Johanna; Fritz, Thomas H.; Hesse, Swen

    2017-01-01

    The role of dopamine D_1-type receptor (D_1R)-expressing neurons in the regulation of motivated behavior and reward prediction has not yet been fully established. As a prerequisite for future research assessing D_1-mediated neuronal network regulation using simultaneous PET/MRI and D_1R-selective ["1"1C]SCH23390, this study investigated the stability of central D_1R measurements between two independent PET/MRI sessions under baseline conditions. Thirteen healthy volunteers (7 female, age 33 ± 13 yrs) underwent 90-min emission scans, each after 90-s bolus injection of 486 ± 16 MBq ["1"1C]SCH23390, on two separate days within 2-4 weeks using a PET/MRI system. Parametric images of D_1R distribution volume ratio (DVR) and binding potential (BP_N_D) were generated by a multi-linear reference tissue model with two parameters and the cerebellar cortex as receptor-free reference region. Volume-of-interest (VOI) analysis was performed with manual VOIs drawn on consecutive transverse MRI slices for brain regions with high and low D_1R density. The DVR varied from 2.5 ± 0.3 to 2.9 ± 0.5 in regions with high D_1R density (e.g. the head of the caudate) and from 1.2 ± 0.1 to 1.6 ± 0.2 in regions with low D_1R density (e.g. the prefrontal cortex). The absolute variability of the DVR ranged from 2.4% ± 1.3% to 5.1% ± 5.3%, while Bland-Altman analyses revealed very low differences in mean DVR (e.g. 0.013 ± 0.17 for the nucleus accumbens). Intraclass correlation (one-way, random) indicated very high agreement (0.93 in average) for both DVR and BP_N_D values. Accordingly, the absolute variability of BP_N_D ranged from 7.0% ± 4.7% to 12.5% ± 10.6%; however, there were regions with very low D_1R content, such as the occipital cortex, with higher mean variability. The test-retest reliability of D_1R measurements in this study was very high. This was the case not only for D_1R-rich brain areas, but also for regions with low D_1R density. These results will provide a solid base

  8. Design, implementation and analysis of fully digital 1-D controllable multiscroll chaos

    KAUST Repository

    Mansingka, Abhinav S.; Radwan, Ahmed G.; Salama, Khaled N.

    2011-01-01

    This paper introduces the fully digital implementation of a 1-D multiscroll chaos generator based on a staircase nonlinearity in the 3rd-order jerk system using the Euler approximation. For the first time, digital design is exploited to provide real-time controllability of (i) number of scrolls, (ii) position in 1-D space, (iii) Euler step size and (iv) system parameter. The effect of variations in these fields on the maximum Lyapunov exponent (MLE) is analyzed. The system is implemented using Verilog HDL and synthesized on an Xilinx Virtex 4 FPGA, exhibiting area utilization less than 3.5% and high performance with experimentally verified throughput up to 3.33 Gbits/s. This fully digital system enables applications in modulation schemes and chaos-based cryptosystems without analog to digital conversion. © 2011 IEEE.

  9. Design, implementation and analysis of fully digital 1-D controllable multiscroll chaos

    KAUST Repository

    Mansingka, Abhinav S.

    2011-12-01

    This paper introduces the fully digital implementation of a 1-D multiscroll chaos generator based on a staircase nonlinearity in the 3rd-order jerk system using the Euler approximation. For the first time, digital design is exploited to provide real-time controllability of (i) number of scrolls, (ii) position in 1-D space, (iii) Euler step size and (iv) system parameter. The effect of variations in these fields on the maximum Lyapunov exponent (MLE) is analyzed. The system is implemented using Verilog HDL and synthesized on an Xilinx Virtex 4 FPGA, exhibiting area utilization less than 3.5% and high performance with experimentally verified throughput up to 3.33 Gbits/s. This fully digital system enables applications in modulation schemes and chaos-based cryptosystems without analog to digital conversion. © 2011 IEEE.

  10. Generation of 3D Virtual Geographic Environment Based on Laser Scanning Technique

    Institute of Scientific and Technical Information of China (English)

    DU Jie; CHEN Xiaoyong; FumioYamazaki

    2003-01-01

    This paper demonstrates an experiment on the generation of 3D virtual geographic environment on the basis of experimental flight laser scanning data by a set of algorithms and methods that were developed to automatically interpret range images for extracting geo-spatial features and then to reconstruct geo-objects. The algorithms and methods for the interpretation and modeling of laser scanner data include triangulated-irregular-network (TIN)-based range image interpolation ; mathematical-morphology(MM)-based range image filtering,feature extraction and range image segmentation, feature generalization and optimization, 3D objects reconstruction and modeling; computergraphics (CG)-based visualization and animation of geographic virtual reality environment.

  11. Vitamin D receptor B1 and exon 1d: functional and evolutionary analysis.

    Science.gov (United States)

    Gardiner, Edith M; Esteban, Luis M; Fong, Colette; Allison, Susan J; Flanagan, Judith L; Kouzmenko, Alexander P; Eisman, John A

    2004-05-01

    The vitamin D receptor (VDR) shares a conserved structural and functional organization with other nuclear receptor (NR) superfamily members. For many NRs, N-terminal variant isoforms that display distinct cell-, stage- and promoter-specific actions have been identified. The novel VDR isoform VDRB1, with a 50 amino acid N-terminal extension, is produced from low abundance transcripts that contain exon 1d of the human VDR locus. There is evidence for the conservation of this exon in other mammalian and avian species. The transactivation differences between VDRB1 and the original VDR, clarified here, provide insights into mechanisms that may contribute to functional differences and potentially distinct physiological roles for these two VDR isoforms.

  12. Generative Fertigung im Maschinenbau - industrieller 3D-Druck auf dem Weg in die Serienproduktion

    OpenAIRE

    Müller, Bernhard

    2014-01-01

    3D-Druck ist aktuell medial omnipräsent, sein Potential für echte industrielle Anwendungen, v. a. im Maschinenbauumfeld, wird kontrovers diskutiert. Der Vortrag gibt einen fundierten Einblick in den Stand der Technik zum industriellen 3D-Druck (Generative Fertigung , Additive Manufacturing) und zeigt spezifische Potentiale mit industrieller Relevanz auf. Dabei werden ebenso Praxisbeispiele aus heutiger Anwendung in der Industrie gezeigt als auch Zukunftsszenarien für potentielle Anwendungen e...

  13. Development of a recombinant poxvirus expressing bovine herpesvirus-1 glycoprotein D

    International Nuclear Information System (INIS)

    Ruiz Saenz, Julian; Osorio, Jorge E; Vera, Victor J.

    2012-01-01

    Bovine herpesvirus-1 is a DNA virus belonging to the family herpesviridae, which affects cattle, causing a wide spectrum of clinical manifestations and economic losses. The main immunogenic component is its envelope glycoprotein d (GD), which has been characterized and used as immunogen in different expression systems. The aim of this work was to generate a recombinant poxvirus (raccoonpox [RCN]) expressing a truncated version of BHV-1 GD to be used as a vaccine. to do this, it was amplified the gene for a truncated version of GD which subsequently was cloned in transfer plasmid PTK/IRES/TPA which has homology to sites of poxvirus thymidine kinase, an internal site of ribosome entry (IRES) and a secretory signal (TPA), generating the construct PTK/GD/IRES/TPA. to generate the recombinant RCN, we took BSC-1 cells and we infected with a wild type RCN (CDC/v71-i-85a) at a multiplicity of infection of 0.05, then cells were transfected with the construct PTK/GD/IRES/TPA, generating different viral populations with and without the gene of interest. To select recombinant viruses expressing the gene of interest, we performed a selection of recombinant thymidine kinase negative and positive for GD by three rounds of plaque purification on rat-2 cells monolayers which are thymidine kinase null and using bromodeoxyuridine. Recombinant viruses were recovered and confirmed by PCR and nucleotide sequencing and so called RCN-GD.

  14. Cellular reactions to three-dimensional matrices of polylactic acid and hydroxyapatite generated by 3D-printing

    Directory of Open Access Journals (Sweden)

    T. V. Druzhinina

    2016-01-01

    Full Text Available The purpose of this study is to estimate Ex vivo physicochemical and biological features of three-dimensional (3D biodegradable matrices “polylactic acid/calcium phosphates” (hereafter 3D composites designed with the help of additive technologies (3D printing as potential materials for bone tissue regeneration.Materials and methods. Experimental samples (disks 1,2–1,6 mm thick, and 11 mm or 8 mm in diameter of composite biodegradable 3D matrices (hereafter 3D composites have been produced from initial mixture of 95 mas% polylactic acid (PLA and 5 mas% hydroxyapatite (HAP. Computer-aided design method, Blender software and fused filament fabrication (FFF; fiber diameter 1,75 mm with 3D printing were used in sample production. 100 mas% PLA disks served as control. One of the sample surfaces was textured with 0,3–0,5 mm wide grooves. Physicochemical properties of 11 mm disks (geometry, mass, morphology, roughness, electrostatic voltage, surface wettability, and element composition were studied. Biological trials included the evaluation of 24-hour cytotoxicity of 8 mm samples in culture of mononuclear leukocytes of a healthy volunteer or human Jurkat T cell leukemia-derived cell line (hereafter Jurkat T cells. Moreover, osteogenic potential of 11 mm disks was determined in 21-day culture of human adipose-derived multipotent mesenchymal stem cells (AMMSCs be means of osteocalcin secretion and intercellular matrix mineralization visualized by alizarin red S staining.Results. The features of PLA-HAP 3D composites generated by 3D printing correspond to physicochemical parameters which are crucial for bone tissue recovery. In case of small amount of calcium and phosphorus they facilitated ex vivo mineralization of extracellular matrix formed in AMMSCs culture. The number of died (by necrosis, mainly leukemic Jurkat T cells but not mononuclear leukocytes of a health volunteer increased to 9–10% in 24-hour in vitro contact with PLA-HAP 3D

  15. α-particle D-state effects in (d,α) reactions

    International Nuclear Information System (INIS)

    Santos, F.D.; Tonsfelt, S.A.; Clegg, T.B.; Ludwig, E.J.; Tagishi, Y.; Wilkerson, J.F.

    1982-01-01

    It is shown that the tensor analyzing powers for (d,α) reactions are sensitive to the D-state component in the α-particle wave function. The D to S-state asymptotic ratio extracted from T 20 and T 22 data in J = L +- 1 transitions is discussed using an α-particle D state generated with the Jackson and Riska model

  16. A 1D version of EllipSys

    DEFF Research Database (Denmark)

    van der Laan, Paul; Sørensen, Niels N.

    2017-01-01

    A one-dimensional version of EllipSys, labeled as EllipSys1D is presented. Three atmospheric boundary layer test cases are used to show that results of EllipSys1D are exactly the same or very similar as results of EllipSys3D, while EllipSys1D uses 3 to 4 orders of magnitude less CPU hours compared...

  17. Synthetic seismograms in laterrally heterogeneous anelastic media: Modal summation for the case of offshore seismic sources (deep-sea trough)

    International Nuclear Information System (INIS)

    Alvarez, Leonardo; Romanelli, Fabio; Panza, Giuliano F.

    2001-12-01

    While waiting for the increment of strong motion data, especially for earthquake prone areas outside the United States and Japan, a very useful approach to perform immediate site specific seismic hazard assessment is the development and use of modelling tools. They are based, on one hand, on the theoretical knowledge of the physics of the seismic source and of wave propagation and, on the other hand, on the exploitation of the relatively rich database, already available, that can be used for the definition of the source and structural models. With these input data we model the ground motion using the mode-coupling approach for sharply varying laterally heterogeneous anelastic media, i.e. computing the coupling coefficients for the modes transmitted and reflected at the vertical interface, between two quarter spaces in welded contact. The formalism can be readily applied to any laterally heterogeneous structure by using a custom series of layered anelastic structures in welded contact at vertical interfaces. The case of seismic wave propagation in smooth varying laterally heterogeneous layered media, is solved with an approximation, equivalent to WKBJ method. The theoretical formulation that combines both WKBJ and the coupling coefficients approaches, is implemented in a computer program package. The computer code we have developed allows us to calculate synthetic seismograms for a wide range of laterally inhomogeneous layered anelastic media. As a case study we use an earthquake which occurred on December 16, 1999 (m b =4.8) beneath the Bartlett sea trough, south of Santiago de Cuba city, that was recorded by an accelerometer (SMA-100) placed in Rio Carpintero (RCC) station, at an epicentral distance of about 30 Km. The path travelled by the waves corresponds to a complex structure from undersea source to inland seismic station. A good fit between the observed transverse component (SH-waves) of acceleration and the corresponding synthetic signal is obtained for a

  18. Crystal structure of 1-ethylpyrazolo[3,4-d]pyrimidine-4(5H-thione

    Directory of Open Access Journals (Sweden)

    Mohammed El Fal

    2014-09-01

    Full Text Available In the title compound, C7H8N4S, the methyl C atom is displaced by 1.232 (7 Å from the mean plane of the pyrazolo[3,4-d]pyrimidine ring system (r.m.s. deviation = 0.007 Å. The N—N—C—Cm (m = methyl torsion angle is −60.3 (6°. In the crystal, molecules are linked by N—H...S hydrogen bonds, generating [010] chains, which are reinforced by C—H...N interactions. The chains are cross-linked by weak C—H...S hydrogen bonds, generating (001 sheets.

  19. WE-G-207-06: 3D Fluoroscopic Image Generation From Patient-Specific 4DCBCT-Based Motion Models Derived From Physical Phantom and Clinical Patient Images

    International Nuclear Information System (INIS)

    Dhou, S; Cai, W; Hurwitz, M; Rottmann, J; Myronakis, M; Cifter, F; Berbeco, R; Lewis, J; Williams, C; Mishra, P; Ionascu, D

    2015-01-01

    Purpose: Respiratory-correlated cone-beam CT (4DCBCT) images acquired immediately prior to treatment have the potential to represent patient motion patterns and anatomy during treatment, including both intra- and inter-fractional changes. We develop a method to generate patient-specific motion models based on 4DCBCT images acquired with existing clinical equipment and used to generate time varying volumetric images (3D fluoroscopic images) representing motion during treatment delivery. Methods: Motion models are derived by deformably registering each 4DCBCT phase to a reference phase, and performing principal component analysis (PCA) on the resulting displacement vector fields. 3D fluoroscopic images are estimated by optimizing the resulting PCA coefficients iteratively through comparison of the cone-beam projections simulating kV treatment imaging and digitally reconstructed radiographs generated from the motion model. Patient and physical phantom datasets are used to evaluate the method in terms of tumor localization error compared to manually defined ground truth positions. Results: 4DCBCT-based motion models were derived and used to generate 3D fluoroscopic images at treatment time. For the patient datasets, the average tumor localization error and the 95th percentile were 1.57 and 3.13 respectively in subsets of four patient datasets. For the physical phantom datasets, the average tumor localization error and the 95th percentile were 1.14 and 2.78 respectively in two datasets. 4DCBCT motion models are shown to perform well in the context of generating 3D fluoroscopic images due to their ability to reproduce anatomical changes at treatment time. Conclusion: This study showed the feasibility of deriving 4DCBCT-based motion models and using them to generate 3D fluoroscopic images at treatment time in real clinical settings. 4DCBCT-based motion models were found to account for the 3D non-rigid motion of the patient anatomy during treatment and have the potential

  20. Customised 3D Printing: An Innovative Training Tool for the Next Generation of Orbital Surgeons.

    Science.gov (United States)

    Scawn, Richard L; Foster, Alex; Lee, Bradford W; Kikkawa, Don O; Korn, Bobby S

    2015-01-01

    Additive manufacturing or 3D printing is the process by which three dimensional data fields are translated into real-life physical representations. 3D printers create physical printouts using heated plastics in a layered fashion resulting in a three-dimensional object. We present a technique for creating customised, inexpensive 3D orbit models for use in orbital surgical training using 3D printing technology. These models allow trainee surgeons to perform 'wet-lab' orbital decompressions and simulate upcoming surgeries on orbital models that replicate a patient's bony anatomy. We believe this represents an innovative training tool for the next generation of orbital surgeons.

  1. SU-D-207A-01: Female Pelvic Synthetic CT Generation Based On Joint Shape and Intensity Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Liu, L; Jolly, S; Cao, Y; Vineberg, K; Fessler, J; Balter, J [University Michigan, Ann Arbor, MI (United States)

    2016-06-15

    Purpose: To develop a method for generating female pelvic synthetic CT (MRCT) images from a single MR scan and evaluate its utility in radiotherapy. Methods: Under IRB-approval, an imaging sequence (T1-VIBE-Dixon) was acquired for 10 patients. This sequence yields 3 useful image volumes of different contrast (“in-phase” T1-weighted, fat and water). A previously published pelvic bone shape model was used to generate a rough bone mask for each patient. A modified fuzzy c-means classification was performed on the multi spectral MR data, with a regularization term that utilizes the prior knowledge provided by the bone mask and addresses the intensity overlap between different tissue types. A weighted sum of classification probabilities with attenuation values yielded MRCT volumes. The mean absolute error (MAE) between MRCT and real CT on various regions was calculated following deformable alignment (Velocity). Intensity modulated Treatment plans based on actual CT and MRCT were made and compared. Results: The average/standard deviation of MAE across 10 patients was 10.1/6.7 HU for muscle, 6.7/4.6 HU for fat, 136.9/53.5 HU for bony tissues under 850 HU (97% of total bone volume), 188.9/119.3 HU for bony tissues above 850 HU and 17.3/13.3 HU for intrapelvic soft tissues. Calculated doses were comparable for plans generated on CT and calculated using MRCT densities or vice versa, with differences in PTV D99% (mean/σ) of (–0.1/0.2 Gy) and (0.3/0.2 Gy), PTV D0.5cc of (–0.3/0.2 Gy) and (–0.4/1.7 Gy). OAR differences were similarly small for comparable structures, with differences in bowel V50Gy of (–0.3/0.2%) and (0.0/0.2%), femur V30Gy of (0.7/1.2%) and (0.2/1.2%), sacrum V20GY of (0.0/0.1%) and (–0.1/1.1%) and mean pelvic V20Gy of (0.0/0.1%) and (0.6/1.8%). Conclusion: MRCT based on a single imaging sequence in the female pelvis is feasible, with acceptably small variations in attenuation estimates and calculated doses to target and critical organs. Work

  2. Compact neutron generators for environmental recovery applications

    International Nuclear Information System (INIS)

    Leung, K. N.; Firestone, R. B.; Lou, T. P.; Reijonen, J.; Vujic, J. Lj.

    2002-01-01

    New generations of compact neutron sources are being developed at the Lawrence Berkeley National Laboratory (LBNL). The D-D or D-T neutron generators can be used to perform precise elemental analysis by Prompt Gamma-Ray Activation Analysis (PGAA) in place of a nuclear reactor. The neutron generators will be composed of an ion source, from which a 1.5 A deuterium beam will be extracted and accelerated to about 150 keV onto a target loaded with deuterium. Based on the D-D nuclear reaction, the neutron generator will yield approximately 10 12 n/s (10 14 n/s for D-T reaction). With this neutron output, thermal and cold neutron fluxes of 10 7 n/s cm 2 and 6 x 10 6 n/s cm 2 have been estimated using neutron moderators designed by the neutron transport simulation code MCNP. (author)

  3. Toward regional-scale adjoint tomography in the deep earth

    Science.gov (United States)

    Masson, Y.; Romanowicz, B. A.

    2013-12-01

    Thanks to the development of efficient numerical computation methods, such as the Spectral Element Method (SEM) and to the increasing power of computer clusters, it is now possible to obtain regional-scale images of the Earth's interior using adjoint-tomography (e.g. Tape, C., et al., 2009). As for now, these tomographic models are limited to the upper layers of the earth, i.e., they provide us with high-resolution images of the crust and the upper part of the mantle. Given the gigantic amount of calculation it represents, obtaing similar models at the global scale (i.e. images of the entire Earth) seems out of reach at the moment. Furthermore, it's likely that the first generation of such global adjoint tomographic models will have a resolution significantly smaller than the current regional models. In order to image regions of interests in the deep Earth, such as plumes, slabs or large low shear velocity provinces (LLSVPs), while keeping the computation tractable, we are developing new tools that will allow us to perform regional-scale adjoint-tomography at arbitrary depths. In a recent study (Masson et al., 2013), we showed that a numerical equivalent of the time reversal mirrors used in experimental acoustics permits to confine the wave propagation computations (i.e. using SEM simulations) inside the region to be imaged. With this ability to limit wave propagation modeling inside a region of interest, obtaining the adjoint sensitivity kernels needed for tomographic imaging is only two steps further. First, the local wavefield modeling needs to be coupled with field extrapolation techniques in order to obtain synthetic seismograms at the surface of the earth. These seismograms will account for the 3D structure inside the region of interest in a quasi-exact manner. We will present preliminary results where the field-extrapolation is performed using Green's function computed in a 1D Earth model thanks to the Direct Solution Method (DSM). Once synthetic seismograms

  4. 1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines.

    Science.gov (United States)

    Lagishetty, Venu; Chun, Rene F; Liu, Nancy Q; Lisse, Thomas S; Adams, John S; Hewison, Martin

    2010-07-01

    Vitamin D-insufficiency is a prevalent condition in populations throughout the world, with low serum levels of 25-hydroxyvitamin D (25OHD) linked to a variety of human health concerns including cancer, autoimmune disease and infection. Current data suggest that 25OHD action involves localized extra-renal conversion to 1,25-dihydroxyvitamin D (1,25(OH)2D) via tissue-specific expression of the enzyme 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-hydroxylase). In cells such as macrophages, expression of 1alpha-hydroxylase is intimately associated with toll-like receptor (TLR) recognition of pathogens. However, this mechanism may not be exclusive to extra-renal generation of 1,25(OH)2D. To investigate the relationship between TLR-mediated pathogen recognition and vitamin D-induced antibacterial activity, intracrine responses to 25OHD metabolism were explored in vitro using the established colonic cell lines Caco-2 and Caco-2 clone BBe. Analysis of antibacterial factors such as cathelicidin (LL37) and beta-defensin-4 (DEFB4) was carried out following co-treatment with TLR ligands. Data indicate that, unlike macrophages, Caco-2 and BBe colonic cell lines are unresponsive to TLR-induced 1alpha-hydroxylase. Alternative activators of 1alpha-hydroxylase such as transforming growth factor beta were also ineffective at priming intracrine responses to 25OHD. Thus, in common with other barrier sites such as the skin or placenta, colonic epithelial cells may require specific factors to initiate intracrine responses to vitamin D. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  5. 1D to 3D diffusion-reaction kinetics of defects in crystals

    DEFF Research Database (Denmark)

    Trinkaus, H.; Heinisch, H.L.; Barashev, A.V.

    2002-01-01

    Microstructural features evolving in crystalline solids from diffusion-reaction kinetics of mobile components depend crucially on the dimension of the underlying diffusion process which is commonly assumed to be three-dimensional (3D). In metals, irradiation-induced displacement cascades produce...... clusters of self-interstitials performing 1D diffusion. Changes between equivalent 1D diffusion paths and transversal diffusion result in diffusion-reaction kinetics between one and three dimensions. An analytical approach suggests a single-variable function (master curve) interpolating between the 1D...

  6. 3D micro-optical elements for generation of tightly focused vortex beams

    Directory of Open Access Journals (Sweden)

    Balčytis Armandas

    2015-01-01

    Full Text Available Orbital angular momentum carrying light beams are usedfor optical trapping and manipulation. This emerging trend provides new challenges involving device miniaturization for improved performance and enhanced functionality at the microscale. Here we discus a new fabrication method based on combining the additive 3D structuring capability laser photopolymerization and the substractive sub-wavelength resolution patterning of focused ion beam lithography to produce micro-optical elements capable of compound functionality. As a case in point of this approach binary spiral zone pattern based high numerical aperture micro-lenses capable of generating topological charge carrying tightly focused vortex beams in a single wavefront transformation step are presented. The devices were modelled using finite-difference time-domain simulations, and the theoretical predictions were verified by optically characterizing the propagation properties of light transmitted through the fabricated structures. The resulting devices had focal lengths close to the predicted values of f = 18 µm and f = 13 µm as well as topological charge ℓ dependent vortex focal spot sizes of ~ 1:3 µm and ~ 2:0 µm for ℓ = 1 and ℓ = 2 respectively.

  7. Memory, reconsolidation and extinction in Lymnaea require the soma of RPeD1.

    Science.gov (United States)

    Sangha, Susan; Varshney, Nishi; Fras, Mary; Smyth, Kim; Rosenegger, David; Parvez, Kashif; Sadamoto, Hisayo; Lukowiak, Ken

    2004-01-01

    The central pattern generator (CPG) that drives aerial respiratory behaviour in Lymnaea consists of 3 neurons. One of these, RPeD1--the cell that initiates activity in the circuit, plays an absolutely necessary role as a site for memory formation, memory reconsolidation, and extinction. Using an operant conditioning training procedure that results in a long-term non-declarative memory (LTM), we decrease the occurrence of aerial respiratory behaviour. Since snails can still breathe cutaneously learning this procedure is not harmful. Concomitant with behavioural memory are changes in the spiking activity of RPeD1. Going beyond neural correlates of memory we directly show that RPeD1 is a necessary site for LTM formation. Expanding on this finding we show that this neuron is also a necessary site for memory reconsolidation and 'Pavlovian' extinction. As far as we can determine, this is the first time a single neuron has been shown to be a necessary site for these different aspects memory. RPeD1 is thus a key neuron mediating different hierarchical aspects of memory. We are now in a position to determine the necessary neuronal, molecular and proteomic events in this neuron that are causal to memory formation, reconsolidation and extinction.

  8. Isotopic labeling affects 1,25-dihydroxyvitamin D metabolism

    International Nuclear Information System (INIS)

    Halloran, B.P.; Bikle, D.D.; Castro, M.E.; Gee, E.

    1989-01-01

    Isotope substitution can change the biochemical properties of vitamin D. To determine the effect of substituting 3H for 1H on the metabolism of 1,25(OH)2D3, we measured the metabolic clearance rate and renal metabolism of unlabeled and 3H-labeled 1,25(OH)2D3. Substitution of 3H for 1H on carbons 26 and 27 [1,25(OH)2[26,27(n)-3H]D3] or on carbons 23 and 24 [1,25(OH)2[23,24(n)-3H]D3] reduced the in vivo metabolic clearance rate of 1,25(OH)2D3 by 36% and 37%, respectively, and reduced the in vitro renal catabolism of 1,25(OH)2D3 by 11% and 54%, respectively. Substitutions of 3H for 1H on carbons 23 and 24 as opposed to carbons 26 and 27 reduced conversion of [3H]1,25(OH)2D3 to [3H]1,24,25(OH)2D3 by 25% and to putative 24-oxo-1,23,25-dihydroxyvitamin D3 by 1600%. These results indicate that substitution of 3H for 1H on carbons 26 and 27 or on carbons 23 and 24 can reduce the metabolic clearance rate and in vitro metabolism of 1,25(OH)2D3 and quantitatively alter the pattern of metabolic products produced

  9. Pharmacokinetics of 1,25(OH)(2)D(3) and 1alpha(OH)D(3) in normal and uraemic men

    DEFF Research Database (Denmark)

    Brandi, Lisbet; Egfjord, Martin; Olgaard, Klaus

    2002-01-01

    ,25(OH)(2)D(3) (n=6) protocol. RESULTS: After oral administration of 1,25(OH)(2)D(3) the bioavailability of 1,25(OH)(2)D(3) was 70.6+/-5.8/72.2+/-4.8% in healthy volunteers/uraemic patients (n.s.). After i.v. administration the volume of distribution of 1,25(OH)(2)D(3) was similar, 0.49+/-0.14 vs 0...

  10. Extracellular dopamine, acetylcholine, and activation of dopamine D1 and D2 receptors after selective breeding for cocaine self-administration in rats.

    Science.gov (United States)

    Xu, Haiyang; Das, Sasmita; Sturgill, Marc; Hodgkinson, Colin; Yuan, Qiaoping; Goldman, David; Grasing, Kenneth

    2017-08-01

    The low self-administration (LS)/Kgras (LS) and high self-administration (HS)/Kgras (HS) rat lines were generated by selective breeding for low- and high-intravenous cocaine self-administration, respectively, from a common outbred Wistar stock (Crl:WI). This trait has remained stable after 13 generations of breeding. The objective of the present study is to compare cocaine preference, neurotransmitter release, and dopamine receptor activation in LS and HS rats. Levels of dopamine, acetylcholine, and cocaine were measured in the nucleus accumbens (NA) shell of HS and LS rats by tandem mass spectrometry of microdialysates. Cocaine-induced locomotor activity and conditioned-place preference were compared between LS and HS rats. HS rats displayed greater conditioned-place preference scores compared to LS and reduced basal extracellular concentrations of dopamine and acetylcholine. However, patterns of neurotransmitter release did not differ between strains. Low-dose cocaine increased locomotor activity in LS rats, but not in HS animals, while high-dose cocaine augmented activity only in HS rats. Either dose of cocaine increased immunoreactivity for c-Fos in the NA shell of both strains, with greater elevations observed in HS rats. Activation identified by cells expressing both c-Fos and dopamine receptors was generally greater in the HS strain, with a similar pattern for both D1 and D2 dopamine receptors. Diminished levels of dopamine and acetylcholine in the NA shell, with enhanced cocaine-induced expression of D1 and D2 receptors, are associated with greater rewarding effects of cocaine in HS rats and an altered dose-effect relationship for cocaine-induced locomotor activity.

  11. 1 MVA HTS-2G Generator for Wind Turbines

    Science.gov (United States)

    Kovalev, K. L.; Poltavets, V. N.; Ilyasov, R. I.; Verzhbitsky, L. G.; Kozub, S. S.

    2017-10-01

    The calculation, design simulations and design performance of 1 MVA HTS-2G (second-generation high-temperature superconductor) Generator for Wind Turbines were done in 2013-2014 [1]. The results of manufacturing and testing of 1 MVA generator are presented in the article. HTS-2G field coils for the rotor were redesigned, fabricated and tested. The tests have shown critical current of the coils, 41-45 A (self field within the ferromagnetic core, T = 77 K), which corresponds to the current of short samples at self field. Application of the copper inner frame on the pole has improved internal cooling conditions of HTS coil windings and reduced the magnetic field in the area, thereby increased the critical current value. The original construction of the rotor with a rotating cryostat was developed, which decreases the thermal in-flow to the rotor. The stator of 1 MW HTS-2G generator has been manufactured. In order to improve the specific weight of the generator, the wave (harmonic drive) multiplier was used, which provides increasing RPM from 15 RPM up to 600 RPM. The total mass of the multiplier and generator is significantly smaller compared to traditional direct-drive wind turbines generators [2-7]. Parameters of the multiplier and generator were chosen based on the actual parameters of wind turbines, namely: 15 RPM, power is 1 MVA. The final test of the assembled synchronous generator with HTS-2G field coils for Wind Turbines with output power 1 MVA was completed during 2015.

  12. A deterministic seismic hazard map of India and adjacent areas

    International Nuclear Information System (INIS)

    Parvez, Imtiyaz A.; Vaccari, Franco; Panza, Giuliano

    2001-09-01

    A seismic hazard map of the territory of India and adjacent areas has been prepared using a deterministic approach based on the computation of synthetic seismograms complete of all main phases. The input data set consists of structural models, seismogenic zones, focal mechanisms and earthquake catalogue. The synthetic seismograms have been generated by the modal summation technique. The seismic hazard, expressed in terms of maximum displacement (DMAX), maximum velocity (VMAX), and design ground acceleration (DGA), has been extracted from the synthetic signals and mapped on a regular grid of 0.2 deg. x 0.2 deg. over the studied territory. The estimated values of the peak ground acceleration are compared with the observed data available for the Himalayan region and found in good agreement. Many parts of the Himalayan region have the DGA values exceeding 0.6 g. The epicentral areas of the great Assam earthquakes of 1897 and 1950 represent the maximum hazard with DGA values reaching 1.2-1.3 g. (author)

  13. Downregulation of dTps1 in Drosophila melanogaster larvae confirms involvement of trehalose in redox regulation following desiccation.

    Science.gov (United States)

    Thorat, Leena; Mani, Krishna-Priya; Thangaraj, Pradeep; Chatterjee, Suvro; Nath, Bimalendu B

    2016-03-01

    As a survival strategy to environmental water deficits, desiccation-tolerant organisms are commonly known for their ability to recruit stress-protective biomolecules such as trehalose. We have previously reported the pivotal role of trehalose in larval desiccation tolerance in Drosophila melanogaster. Trehalose has emerged as a versatile molecule, serving mainly as energy source in insects and also being a stress protectant. While several recent reports have revealed the unconventional role of trehalose in scavenging reactive oxygen species in yeast and plants, this aspect has not received much attention in animals. We examined the status of desiccation-induced generation of reactive oxygen species in D. melanogaster larvae and the possible involvement of trehalose in ameliorating the harmful consequences thereof. Insect trehalose synthesis is governed by the enzyme trehalose 6-phosphate synthase 1 (TPS1). Using the ubiquitous da-GAL4-driven expression of the dTps1-RNAi transgene, we generated dTps1-downregulated Drosophila larvae possessing depleted levels of dTps1 transcripts. This resulted in the inability of the larvae for trehalose synthesis, thereby allowing us to elucidate the significance of trehalose in the regulation of desiccation-responsive redox homeostasis. Furthermore, the results from molecular genetics studies, biochemical assays, electron spin resonance analyses and a simple, non-invasive method of whole larval live imaging suggested that trehalose in collaboration with superoxide dismutase (SOD) is involved in the maintenance of redox state in D. melanogaster.

  14. Solution to automatic generation control problem using firefly algorithm optimized I(λ)D(µ) controller.

    Science.gov (United States)

    Debbarma, Sanjoy; Saikia, Lalit Chandra; Sinha, Nidul

    2014-03-01

    Present work focused on automatic generation control (AGC) of a three unequal area thermal systems considering reheat turbines and appropriate generation rate constraints (GRC). A fractional order (FO) controller named as I(λ)D(µ) controller based on crone approximation is proposed for the first time as an appropriate technique to solve the multi-area AGC problem in power systems. A recently developed metaheuristic algorithm known as firefly algorithm (FA) is used for the simultaneous optimization of the gains and other parameters such as order of integrator (λ) and differentiator (μ) of I(λ)D(µ) controller and governor speed regulation parameters (R). The dynamic responses corresponding to optimized I(λ)D(µ) controller gains, λ, μ, and R are compared with that of classical integer order (IO) controllers such as I, PI and PID controllers. Simulation results show that the proposed I(λ)D(µ) controller provides more improved dynamic responses and outperforms the IO based classical controllers. Further, sensitivity analysis confirms the robustness of the so optimized I(λ)D(µ) controller to wide changes in system loading conditions and size and position of SLP. Proposed controller is also found to have performed well as compared to IO based controllers when SLP takes place simultaneously in any two areas or all the areas. Robustness of the proposed I(λ)D(µ) controller is also tested against system parameter variations. © 2013 ISA. Published by Elsevier Ltd. All rights reserved.

  15. Software R&D for Next Generation of HEP Experiments, Inspired by Theano

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    In the next decade, the frontiers of High Energy Physics (HEP) will be explored by three machines: the High Luminosity Large Hadron Collider (HL-LHC) in Europe, the Long Base Neutrino Facility (LBNF) in the US, and the International Linear Collider (ILC) in Japan. These next generation experiments must address two fundamental problems in the current generation of HEP experimental software: the inability to take advantage and adapt to the rapidly evolving processor landscape, and the difficulty in developing and maintaining increasingly complex software systems by physicists. I will propose a strategy, inspired by the automatic optimization and code generation in Theano, to simultaneously address both problems. I will describe three R&D projects with short-term physics deliverables aimed at developing this strategy. The first project is to develop maximally sensitive General Search for New Physics at the LHC by applying the Matrix Element Method running GPUs of HPCs. The second is to classify and reconstru...

  16. R and D areas for next generation desalination and water purification technologies

    International Nuclear Information System (INIS)

    Raha, A.; Rao, I.S.; Srivastava, V.K.; Tewari, P.K.

    2007-01-01

    By 2020, desalination and water purification technologies are expected to contribute significantly to ensure a safe, sustainable, affordable and adequate water supply. The cost of producing water from the current generation desalination technologies has declined over time at a rate of only approximately 4% per year. So we need to accelerate our research and development (R and D) activities with a near and long term objective for evolution of current generation desalination technology and to create revolutionary next generation advanced desalination and water purification technologies which will offer a promise of step reduction in cost of producing water. There are five broad technological areas-thermal technologies, membrane technologies, alternate technologies, concentrate management technologies, reuse and recycle technologies that encompass the spectrum of desalination technology. In this paper high priority research areas in all the above technologies areas are discussed to make decision about research direction that will help to mitigate our nation's future water supply challenges. (author)

  17. Earthquake—explosion discrimination using genetic algorithm-based boosting approach

    Science.gov (United States)

    Orlic, Niksa; Loncaric, Sven

    2010-02-01

    An important and challenging problem in seismic data processing is to discriminate between natural seismic events such as earthquakes and artificial seismic events such as explosions. Many automatic techniques for seismogram classification have been proposed in the literature. Most of these methods have a similar approach to seismogram classification: a predefined set of features based on ad-hoc feature selection criteria is extracted from the seismogram waveform or spectral data and these features are used for signal classification. In this paper we propose a novel approach for seismogram classification. A specially formulated genetic algorithm has been employed to automatically search for a near-optimal seismogram feature set, instead of using ad-hoc feature selection criteria. A boosting method is added to the genetic algorithm when searching for multiple features in order to improve classification performance. A learning set of seismogram data is used by the genetic algorithm to discover a near-optimal feature set. The feature set identified by the genetic algorithm is then used for seismogram classification. The described method is developed to classify seismograms in two groups, whereas a brief overview of method extension for multiple group classification is given. For method verification, a learning set consisting of 40 local earthquake seismograms and 40 explosion seismograms was used. The method was validated on seismogram set consisting of 60 local earthquake seismograms and 60 explosion seismograms, with correct classification of 85%.

  18. New scotogenic model of neutrino mass with U(1){sub D} gauge interaction

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Ernest [Department of Physics and Astronomy, University of California, Riverside, CA 92521 (United States); Picek, Ivica; Radovčić, Branimir [Department of Physics, Faculty of Science, University of Zagreb, P.O.B. 331, HR-10002 Zagreb (Croatia)

    2013-11-04

    We propose a new realization of the one-loop radiative model of neutrino mass generated by dark matter (scotogenic), where the particles in the loop have an additional U(1){sub D} gauge symmetry, which may be exact or broken to Z{sub 2}. This model is relevant to a number of astrophysical observations, including AMS-02 and the dark-matter distribution in dwarf galactic halos.

  19. Electron thermal capacity in plasma generated at cavitation bubble collapse in D-acetone

    International Nuclear Information System (INIS)

    Kostenko, B.F.; Pribis, J.

    2004-01-01

    The latest experimental data on nuclear reaction product registration at cavitation bubble collapse in deuterated acetone (C 3 D 6 O) still argue in favour of existence of a new possibility to realize the thermonuclear synthesis. Theoretical description based on numerical solution of simultaneous conservation equations for gaseous and liquid phases also confirms this possibility, although it requires further more precise definitions. In particular, description of electron degrees of freedom in dense nonequilibrium plasma generated at the final stage of bubble collapse need specification. Calculations of electron thermal capacity in the deuterated acetone multiple ionization region at electron temperatures T e ≅ 10 4 K and above and compression range ρ/ρ 0 ≅ 1 - 100 have been fulfilled on the basis of direct numerical solution of equation for chemical potential. (author)

  20. Nuclear generation cost and nuclear research development fund

    International Nuclear Information System (INIS)

    Kim, S. S.; Song, G. D.

    2000-01-01

    The main objective of this study is to analyze the effects of nuclear R and D fund to nuclear generation cost and to assess the adaptability of fund size through the comparison with the nuclear research fund in Japan. It was estimated that nuclear R and D fund increased the average annual unit cost of nuclear power generation by 1.14 won/kWh. When the size of nuclear R and D fund is compared with that in Japan, this study suggests that the current nuclear R and D fund should be largely increased taking into consideration the ratio of R and D fund to nuclear generation

  1. Development of a 3D consistent 1D neutronics model for reactor core simulation

    International Nuclear Information System (INIS)

    Lee, Ki Bog; Joo, Han Gyu; Cho, Byung Oh; Zee, Sung Quun

    2001-02-01

    In this report a 3D consistent 1D model based on nonlinear analytic nodal method is developed to reproduce the 3D results. During the derivation, the current conservation factor (CCF) is introduced which guarantees the same axial neutron currents obtained from the 1D equation as the 3D reference values. Furthermore in order to properly use 1D group constants, a new 1D group constants representation scheme employing tables for the fuel temperature, moderator density and boron concentration is developed and functionalized for the control rod tip position. To test the 1D kinetics model with CCF, several steady state and transient calculations were performed and compared with 3D reference values. The errors of K-eff values were reduced about one tenth when using CCF without significant computational overhead. And the errors of power distribution were decreased to the range of one fifth or tenth at steady state calculation. The 1D kinetics model with CCF and the 1D group constant functionalization employing tables as a function of control rod tip position can provide preciser results at the steady state and transient calculation. Thus it is expected that the 1D kinetics model derived in this report can be used in the safety analysis, reactor real time simulation coupled with system analysis code, operator support system etc.

  2. A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism

    Science.gov (United States)

    Hasbi, Ahmed; Perreault, Melissa L.; Shen, Maurice Y. F.; Zhang, Lucia; To, Ryan; Fan, Theresa; Nguyen, Tuan; Ji, Xiaodong; O'Dowd, Brian F.; George, Susan R.

    2014-01-01

    Although the dopamine D1-D2 receptor heteromer has emerging physiological relevance and a postulated role in different neuropsychiatric disorders, such as drug addiction, depression, and schizophrenia, there is a need for pharmacological tools that selectively target such receptor complexes in order to analyze their biological and pathophysiological functions. Since no selective antagonists for the D1-D2 heteromer are available, serial deletions and point mutations were used to precisely identify the amino acids involved in an interaction interface between the receptors, residing within the carboxyl tail of the D1 receptor that interacted with the D2 receptor to form the D1-D2 receptor heteromer. It was determined that D1 receptor carboxyl tail residues 404Glu and 405Glu were critical in mediating the interaction with the D2 receptor. Isolated mutation of these residues in the D1 receptor resulted in the loss of agonist activation of the calcium signaling pathway mediated through the D1-D2 receptor heteromer. The physical interaction between the D1 and D2 receptor could be disrupted, as shown by coimmunoprecipitation and BRET analysis, by a small peptide generated from the D1 receptor sequence that contained these amino acids, leading to a switch in G-protein affinities and loss of calcium signaling, resulting in the inhibition of D1-D2 heteromer function. The use of the D1-D2 heteromer-disrupting peptide in vivo revealed a pathophysiological role for the D1-D2 heteromer in the modulation of behavioral despair. This peptide may represent a novel pharmacological tool with potential therapeutic benefits in depression treatment.—Hasbi, A., Perreault, M. L., Shen, M. Y. F., Zhang, L., To, R., Fan, T., Nguyen, T., Ji, X., O'Dowd, B. F., George, S. R. A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism. PMID:25063849

  3. ESO science data product standard for 1D spectral products

    Science.gov (United States)

    Micol, Alberto; Arnaboldi, Magda; Delmotte, Nausicaa A. R.; Mascetti, Laura; Retzlaff, Joerg

    2016-07-01

    The ESO Phase 3 process allows the upload, validation, storage, and publication of reduced data through the ESO Science Archive Facility. Since its introduction, 2 million data products have been archived and published; 80% of them are one-dimensional extracted and calibrated spectra. Central to Phase3 is the ESO science data product standard that defines metadata and data format of any product. This contribution describes the ESO data standard for 1d-spectra, its adoption by the reduction pipelines of selected instrument modes for in-house generation of reduced spectra, the enhanced archive legacy value. Archive usage statistics are provided.

  4. Gigantic 2D laser-induced photovoltaic effect in magnetically doped topological insulators for surface zero-bias spin-polarized current generation

    Science.gov (United States)

    Shikin, A. M.; Voroshin, V. Yu; Rybkin, A. G.; Kokh, K. A.; Tereshchenko, O. E.; Ishida, Y.; Kimura, A.

    2018-01-01

    A new kind of 2D photovoltaic effect (PVE) with the generation of anomalously large surface photovoltage up to 210 meV in magnetically doped topological insulators (TIs) has been studied by the laser time-resolved pump-probe angle-resolved photoelectron spectroscopy. The PVE has maximal efficiency for TIs with high occupation of the upper Dirac cone (DC) states and the Dirac point located inside the fundamental energy gap. For TIs with low occupation of the upper DC states and the Dirac point located inside the valence band the generated surface photovoltage is significantly reduced. We have shown that the observed giant PVE is related to the laser-generated electron-hole asymmetry followed by accumulation of the photoexcited electrons at the surface. It is accompanied by the 2D relaxation process with the generation of zero-bias spin-polarized currents flowing along the topological surface states (TSSs) outside the laser beam spot. As a result, the spin-polarized current generates an effective in-plane magnetic field that is experimentally confirmed by the k II-shift of the DC relative to the bottom non-spin-polarized conduction band states. The realized 2D PVE can be considered as a source for the generation of zero-bias surface spin-polarized currents and the laser-induced local surface magnetization developed in such kind 2D TSS materials.

  5. 10 CFR Appendix D to Subpart D of... - Classes of Actions That Normally Require EISs

    Science.gov (United States)

    2010-01-01

    .../operation/decommissioning of reactors D5. Main transmission system additions D6. Integrating transmission facilities D7. Allocation of electric power, major new generation resources/major changes in operation of... waste) D1Strategic Systems, as defined in DOE Order 430.1, “Life-Cycle Asset Management,” and designated...

  6. Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle.

    Science.gov (United States)

    Vichaiwong, Kanokwan; Purohit, Suneet; An, Ding; Toyoda, Taro; Jessen, Niels; Hirshman, Michael F; Goodyear, Laurie J

    2010-10-15

    TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab-GAP (GTPase-activating protein) that is highly expressed in skeletal muscle, but little is known about TBC1D1 regulation and function. We studied TBC1D1 phosphorylation on three predicted AMPK (AMP-activated protein kinase) phosphorylation sites (Ser231, Ser660 and Ser700) and one predicted Akt phosphorylation site (Thr590) in control mice, AMPKα2 inactive transgenic mice (AMPKα2i TG) and Akt2-knockout mice (Akt2 KO). Muscle contraction significantly increased TBC1D1 phosphorylation on Ser231 and Ser660, tended to increase Ser700 phosphorylation, but had no effect on Thr590. AICAR (5-aminoimidazole-4-carboxyamide ribonucleoside) also increased phosphorylation on Ser231, Ser660 and Ser700, but not Thr590, whereas insulin only increased Thr590 phosphorylation. Basal and contraction-stimulated TBC1D1 Ser231, Ser660 and Ser700 phosphorylation were greatly reduced in AMPKα2i TG mice, although contraction still elicited a small increase in phosphorylation. Akt2 KO mice had blunted insulin-stimulated TBC1D1 Thr590 phosphorylation. Contraction-stimulated TBC1D1 Ser231 and Ser660 phosphorylation were normal in high-fat-fed mice. Glucose uptake in vivo was significantly decreased in tibialis anterior muscles overexpressing TBC1D1 mutated on four predicted AMPK phosphorylation sites. In conclusion, contraction causes site-specific phosphorylation of TBC1D1 in skeletal muscle, and TBC1D1 phosphorylation on AMPK sites regulates contraction-stimulated glucose uptake. AMPK and Akt regulate TBC1D1 phosphorylation, but there must be additional upstream kinases that mediate TBC1D1 phosphorylation in skeletal muscle.

  7. Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers

    Science.gov (United States)

    Navarro, Gemma; Moreno, Estefania; Bonaventura, Jordi; Brugarolas, Marc; Farré, Daniel; Aguinaga, David; Mallol, Josefa; Cortés, Antoni; Casadó, Vicent; Lluís, Carmen; Ferre, Sergi

    2013-01-01

    Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine receptors and inputs of aversion coming from neurons containing the D2-like family of dopamine receptors. Cocaine is able to subvert these balanced inputs by altering the cell signaling of these two pathways such that D1 reward seeking pathway dominates. Here, we provide an explanation at the cellular and biochemical level how cocaine may achieve this. Exploring the effect of cocaine on dopamine D2 receptors function, we present evidence of σ1 receptor molecular and functional interaction with dopamine D2 receptors. Using biophysical, biochemical, and cell biology approaches, we discovered that D2 receptors (the long isoform of the D2 receptor) can complex with σ1 receptors, a result that is specific to D2 receptors, as D3 and D4 receptors did not form heteromers. We demonstrate that the σ1-D2 receptor heteromers consist of higher order oligomers, are found in mouse striatum and that cocaine, by binding to σ1 -D2 receptor heteromers, inhibits downstream signaling in both cultured cells and in mouse striatum. In contrast, in striatum from σ1 knockout animals these complexes are not found and this inhibition is not seen. Taken together, these data illuminate the mechanism by which the initial exposure to cocaine can inhibit signaling via D2 receptor containing neurons, destabilizing the delicate signaling balance influencing drug seeking that emanates from the D1 and D2 receptor containing neurons in the brain. PMID:23637801

  8. Styrylpyrylium Salts: 1H and 13C NMR High-Resolution Spectroscopy (1D and 2D

    Directory of Open Access Journals (Sweden)

    Jean Claude W. Ouédraogo

    2010-01-01

    Full Text Available 1H and 13C NMR high-resolution spectroscopy (1D and 2D (1H, 1H-COSY, HSQC, HMBC for four styrylpyrylium perchlorates were carried out and signal attributions are reported. Chemical shifts observed on 13C NMR spectra for the styrylpyrylium salts were compared with net atomic charge for carbon obtained by AM1 semiempirical calculations. The position of the styryl group present low effect on chemical shifts for carbon atoms, while the presence of methyl group led to the unshielding of the substituted carbon.

  9. Design and 3D printing of controllable-pitch archimedean screw for pico hydropower generation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Tae; Kim, Eun Seob; Chu, Won Shik; Ahn, Sung Hoon [Seoul National University, Seoul (Korea, Republic of)

    2015-11-15

    Renewable energy has attracted considerable attention because the energy problem has become a worldwide issue. The development of pico-hydropower generation, as a component of distributed generation, has been a subject of concern. In particular, the Archimedean screw generator (ASG) has more benefits, such as low cost, easy maintenance, and fish-friendly characteristic, compared with other types of hydro turbine. Despite these advantages, no appropriate design theory of ASG and Controllable-pitch Archimedean screw (CPAS) exists. Hence, a design theory of ASG and CPAS was theoretically investigated and designed in this study. CPAS was designed for a small-scale hydro-power generation system. With a 3D printer, fused deposition modeling was used to fabricate the blade of CPAS with polylactic acid and epoxy surface coating. A performance evaluation was conducted and analyzed. Results indicate a similar trend with the proposed theory. The power generation was 123 W and efficiency was 71% in 0.04 m{sup 3}/s.

  10. Design and 3D printing of controllable-pitch archimedean screw for pico hydropower generation

    International Nuclear Information System (INIS)

    Lee, Kyung Tae; Kim, Eun Seob; Chu, Won Shik; Ahn, Sung Hoon

    2015-01-01

    Renewable energy has attracted considerable attention because the energy problem has become a worldwide issue. The development of pico-hydropower generation, as a component of distributed generation, has been a subject of concern. In particular, the Archimedean screw generator (ASG) has more benefits, such as low cost, easy maintenance, and fish-friendly characteristic, compared with other types of hydro turbine. Despite these advantages, no appropriate design theory of ASG and Controllable-pitch Archimedean screw (CPAS) exists. Hence, a design theory of ASG and CPAS was theoretically investigated and designed in this study. CPAS was designed for a small-scale hydro-power generation system. With a 3D printer, fused deposition modeling was used to fabricate the blade of CPAS with polylactic acid and epoxy surface coating. A performance evaluation was conducted and analyzed. Results indicate a similar trend with the proposed theory. The power generation was 123 W and efficiency was 71% in 0.04 m"3/s

  11. The vitamin D analogue ED71 but Not 1,25(OH2D3 targets HIF1α protein in osteoclasts.

    Directory of Open Access Journals (Sweden)

    Yuiko Sato

    Full Text Available Although both an active form of the vitamin D metabolite, 1,25(OH2D3, and the vitamin D analogue, ED71 have been used to treat osteoporosis, anti-bone resorbing activity is reportedly seen only in ED71- but not in 1,25(OH2D3 -treated patients. In addition, how ED71 inhibits osteoclast activity in patients has not been fully characterized. Recently, HIF1α expression in osteoclasts was demonstrated to be required for development of post-menopausal osteoporosis. Here we show that ED71 but not 1,25(OH2D3, suppress HIF1α protein expression in osteoclasts in vitro. We found that 1,25(OH2D3 or ED71 function in osteoclasts requires the vitamin D receptor (VDR. ED71 was significantly less effective in inhibiting M-CSF and RANKL-stimulated osteoclastogenesis than was 1,25(OH2D3 in vitro. Downregulation of c-Fos protein and induction of Ifnβ mRNA in osteoclasts, both of which reportedly block osteoclastogenesis induced by 1,25(OH2D3 in vitro, were both significantly higher following treatment with 1,25(OH2D3 than with ED71. Thus, suppression of HIF1α protein activity in osteoclasts in vitro, which is more efficiently achieved by ED71 rather than by 1,25(OH2D3, could be a reliable read-out in either developing or screening reagents targeting osteoporosis.

  12. Simulating high-frequency seismograms in complicated media: A spectral approach

    International Nuclear Information System (INIS)

    Orrey, J.L.; Archambeau, C.B.

    1993-01-01

    The main attraction of using a spectral method instead of a conventional finite difference or finite element technique for full-wavefield forward modeling in elastic media is the increased accuracy of a spectral approximation. While a finite difference method accurate to second order typically requires 8 to 10 computational grid points to resolve the smallest wavelengths on a 1-D grid, a spectral method that approximates the wavefield by trignometric functions theoretically requires only 2 grid points per minimum wavelength and produces no numerical dispersion from the spatial discretization. The resultant savings in computer memory, which is very significant in 2 and 3 dimensions, allows for larger scale and/or higher frequency simulations

  13. Ds1*(2860) and Ds3*(2860): candidates for 1D charmed-strange mesons

    International Nuclear Information System (INIS)

    Song, Qin-Tao; Chen, Dian-Yong; Liu, Xiang; Matsuki, Takayuki

    2015-01-01

    Newly observed two charmed-strange resonances, D s1 * (2860) and D s3 * (2860), are investigated by calculating their Okubo-Zweig-Iizuka-allowed strong decays, which shows that they are suitable candidates for the 1 3 D 1 and 1 3 D 3 states in the charmed-strange meson family. Our study also predicts other main decay modes of D s1 * (2860) and D s3 * (2860), which can be accessible at the future experiment. In addition, the decay behaviors of the spin partners of D s1 * (2860) and D s3 * (2860), i.e., 1D(2 - ) and 1D'(2 - ), are predicted in this work, which are still missing at present. The experimental search for the missing 1D(2 - ) and 1D'(2 - ) charmed-strange mesons is an intriguing and challenging task for further experiments. (orig.)

  14. Report on the results of the R and D of a 200 t/d entrained bed coal gasification pilot plant. Summary - Part 1. Volume 1: Outline of the R and D/Volume 2: Outline of the details of execution of the R and D/Investigational study of verification plant; 1986- 200t/nichi funryusho sekitan gaska hatsuden pilot plant no kenkyu seika hokokusho (Matome). Sono 1. Dai 1 hen kenkyu kaihatsu no gaiyo, Dai 2 hen kenkyu kaihatsu jisshi keii no gaiyo

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-01-01

    A project was finished which had been carried out for 11 years since 1986 for technology of the entrained bed coal gasification power generation technology using a 200 t/d coal gasification combined cycle power generation pilot plant, and it was comprehensively summed up. In Volume 1: Outline of the R and D, the following were summarized: object and background, details of selection of the basic system, objectives and subjects of the R and D, developmental items of 200 t/d pilot plant, outline of pilot plant, place of execution of the R and D and system of the R and D, response to procedures for approval from government offices, etc. In Volume 2: Outline of the details of execution of the R and D, state of design/manufacture/construction, state of operational study, state of dismantling study, important notice at the time of design of pilot plant and the evaluation, outline of the execution of element study, outline of the details of the studies made public overseas. In Investigational study of verification plant, the basic viewpoint of conceptual design, conditions for conceptual design/basic design, outline of the results of the study every fiscal year, finally obtained results of the conceptual design, points to be considered in the design of verification plant, etc. (NEDO)

  15. The D1 parameter for the equatorial F1 region

    International Nuclear Information System (INIS)

    Adeniyi, J.O.; Radicella, S.M.

    2002-01-01

    This work is a contribution to the effort at improving the representation of the F1 equatorial ionospheric region in the International Reference Ionosphere (IRI) model. The D1 parameter has been proposed for describing the F1 layer. We have therefore produced a maiden table of D1 parameter for an equatorial station. Diurnal and seasonal effects were considered. (author)

  16. Towards next generation 3D cameras

    Science.gov (United States)

    Gupta, Mohit

    2017-03-01

    We are in the midst of a 3D revolution. Robots enabled by 3D cameras are beginning to autonomously drive cars, perform surgeries, and manage factories. However, when deployed in the real-world, these cameras face several challenges that prevent them from measuring 3D shape reliably. These challenges include large lighting variations (bright sunlight to dark night), presence of scattering media (fog, body tissue), and optically complex materials (metal, plastic). Due to these factors, 3D imaging is often the bottleneck in widespread adoption of several key robotics technologies. I will talk about our work on developing 3D cameras based on time-of-flight and active triangulation that addresses these long-standing problems. This includes designing `all-weather' cameras that can perform high-speed 3D scanning in harsh outdoor environments, as well as cameras that recover shape of objects with challenging material properties. These cameras are, for the first time, capable of measuring detailed (robotic inspection and assembly systems.

  17. The optimization of high resolution topographic data for 1D hydrodynamic models

    International Nuclear Information System (INIS)

    Ales, Ronovsky; Michal, Podhoranyi

    2016-01-01

    The main focus of our research presented in this paper is to optimize and use high resolution topographical data (HRTD) for hydrological modelling. Optimization of HRTD is done by generating adaptive mesh by measuring distance of coarse mesh and the surface of the dataset and adapting the mesh from the perspective of keeping the geometry as close to initial resolution as possible. Technique described in this paper enables computation of very accurate 1-D hydrodynamic models. In the paper, we use HEC-RAS software as a solver. For comparison, we have chosen the amount of generated cells/grid elements (in whole discretization domain and selected cross sections) with respect to preservation of the accuracy of the computational domain. Generation of the mesh for hydrodynamic modelling is strongly reliant on domain size and domain resolution. Topographical dataset used in this paper was created using LiDAR method and it captures 5.9km long section of a catchment of the river Olše. We studied crucial changes in topography for generated mesh. Assessment was done by commonly used statistical and visualization methods.

  18. The optimization of high resolution topographic data for 1D hydrodynamic models

    Science.gov (United States)

    Ales, Ronovsky; Michal, Podhoranyi

    2016-06-01

    The main focus of our research presented in this paper is to optimize and use high resolution topographical data (HRTD) for hydrological modelling. Optimization of HRTD is done by generating adaptive mesh by measuring distance of coarse mesh and the surface of the dataset and adapting the mesh from the perspective of keeping the geometry as close to initial resolution as possible. Technique described in this paper enables computation of very accurate 1-D hydrodynamic models. In the paper, we use HEC-RAS software as a solver. For comparison, we have chosen the amount of generated cells/grid elements (in whole discretization domain and selected cross sections) with respect to preservation of the accuracy of the computational domain. Generation of the mesh for hydrodynamic modelling is strongly reliant on domain size and domain resolution. Topographical dataset used in this paper was created using LiDAR method and it captures 5.9km long section of a catchment of the river Olše. We studied crucial changes in topography for generated mesh. Assessment was done by commonly used statistical and visualization methods.

  19. The optimization of high resolution topographic data for 1D hydrodynamic models

    Energy Technology Data Exchange (ETDEWEB)

    Ales, Ronovsky, E-mail: ales.ronovsky@vsb.cz; Michal, Podhoranyi [IT4Innovations National Supercomputing Center, VŠB-Technical University of Ostrava, Studentská 6231/1B, 708 33 Ostrava (Czech Republic)

    2016-06-08

    The main focus of our research presented in this paper is to optimize and use high resolution topographical data (HRTD) for hydrological modelling. Optimization of HRTD is done by generating adaptive mesh by measuring distance of coarse mesh and the surface of the dataset and adapting the mesh from the perspective of keeping the geometry as close to initial resolution as possible. Technique described in this paper enables computation of very accurate 1-D hydrodynamic models. In the paper, we use HEC-RAS software as a solver. For comparison, we have chosen the amount of generated cells/grid elements (in whole discretization domain and selected cross sections) with respect to preservation of the accuracy of the computational domain. Generation of the mesh for hydrodynamic modelling is strongly reliant on domain size and domain resolution. Topographical dataset used in this paper was created using LiDAR method and it captures 5.9km long section of a catchment of the river Olše. We studied crucial changes in topography for generated mesh. Assessment was done by commonly used statistical and visualization methods.

  20. Molecular, Physicochemical and Rheological Characteristics of Introgressive Triticale/Triticum monococcum ssp. monococcum Lines with Wheat 1D/1A Chromosome Substitution

    Directory of Open Access Journals (Sweden)

    Lidia Błaszczyk

    2013-07-01

    Full Text Available Three sets of hexaploid introgressive triticale lines, with Triticum monococcum ssp. monococcum (cultivated einkorn wheat genes and a bread wheat chromosome 1D substituted for chromosome 1A, and one set of secondary triticale lines were evaluated for grain and flour physicochemical and dough rheological characteristics in two generations (F7 and F8. Genomic in situ hybridization (GISH and fluorescence in situ hybridization (FISH confirmed the 1D/1A chromosome substitution. The presence or absence of einkorn high-molecular-weight (HMW glutenin subunits and the wheat Glu-D1d locus encoding the 5 + 10 subunits was assessed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE, capillary zone electrophoresis, and allele-specific molecular markers. Significant differences were found among physicochemical properties (with the exception of the Hagberg falling number of all introgressive Triticale/T. monococcum lines and the secondary triticale lines. The wheat 1D/1A chromosome substitution also affected these properties. The results showed that in all introgressive triticale lines, the protein and gluten content, Zeleny sedimentation value, and water absorption capacity, were increased. The rheological parameters estimated using micro-farinograph, reomixer, and Kieffer dough extensibility systems also showed an appreciable increase in dough-mixing properties, maximum resistance to extension (Rmax, and dough extensibility. Introgressive Triticale/T. monococcum lines with 5 + 10 subunits have particularly favorable rheological parameters. The results obtained in this study suggest that the cultivated einkorn genome Am, in the context of hexaploid secondary triticale lines and with a wheat 1D/1A substitution, has the potential to improve gluten polymer interactions and be a valuable genetic resource for triticale quality improvement.

  1. TBC1D24 genotype–phenotype correlation

    Science.gov (United States)

    Balestrini, Simona; Milh, Mathieu; Castiglioni, Claudia; Lüthy, Kevin; Finelli, Mattea J.; Verstreken, Patrik; Cardon, Aaron; Stražišar, Barbara Gnidovec; Holder, J. Lloyd; Lesca, Gaetan; Mancardi, Maria M.; Poulat, Anne L.; Repetto, Gabriela M.; Banka, Siddharth; Bilo, Leonilda; Birkeland, Laura E.; Bosch, Friedrich; Brockmann, Knut; Cross, J. Helen; Doummar, Diane; Félix, Temis M.; Giuliano, Fabienne; Hori, Mutsuki; Hüning, Irina; Kayserili, Hulia; Kini, Usha; Lees, Melissa M.; Meenakshi, Girish; Mewasingh, Leena; Pagnamenta, Alistair T.; Peluso, Silvio; Mey, Antje; Rice, Gregory M.; Rosenfeld, Jill A.; Taylor, Jenny C.; Troester, Matthew M.; Stanley, Christine M.; Ville, Dorothee; Walkiewicz, Magdalena; Falace, Antonio; Fassio, Anna; Lemke, Johannes R.; Biskup, Saskia; Tardif, Jessica; Ajeawung, Norbert F.; Tolun, Aslihan; Corbett, Mark; Gecz, Jozef; Afawi, Zaid; Howell, Katherine B.; Oliver, Karen L.; Berkovic, Samuel F.; Scheffer, Ingrid E.; de Falco, Fabrizio A.; Oliver, Peter L.; Striano, Pasquale; Zara, Federico

    2016-01-01

    Objective: To evaluate the phenotypic spectrum associated with mutations in TBC1D24. Methods: We acquired new clinical, EEG, and neuroimaging data of 11 previously unreported and 37 published patients. TBC1D24 mutations, identified through various sequencing methods, can be found online (http://lovd.nl/TBC1D24). Results: Forty-eight patients were included (28 men, 20 women, average age 21 years) from 30 independent families. Eighteen patients (38%) had myoclonic epilepsies. The other patients carried diagnoses of focal (25%), multifocal (2%), generalized (4%), and unclassified epilepsy (6%), and early-onset epileptic encephalopathy (25%). Most patients had drug-resistant epilepsy. We detail EEG, neuroimaging, developmental, and cognitive features, treatment responsiveness, and physical examination. In silico evaluation revealed 7 different highly conserved motifs, with the most common pathogenic mutation located in the first. Neuronal outgrowth assays showed that some TBC1D24 mutations, associated with the most severe TBC1D24-associated disorders, are not necessarily the most disruptive to this gene function. Conclusions: TBC1D24-related epilepsy syndromes show marked phenotypic pleiotropy, with multisystem involvement and severity spectrum ranging from isolated deafness (not studied here), benign myoclonic epilepsy restricted to childhood with complete seizure control and normal intellect, to early-onset epileptic encephalopathy with severe developmental delay and early death. There is no distinct correlation with mutation type or location yet, but patterns are emerging. Given the phenotypic breadth observed, TBC1D24 mutation screening is indicated in a wide variety of epilepsies. A TBC1D24 consortium was formed to develop further research on this gene and its associated phenotypes. PMID:27281533

  2. Search for all d-MPs for all d levels in multistate two-terminal networks

    International Nuclear Information System (INIS)

    Bai, Guanghan; Zuo, Ming J.; Tian, Zhigang

    2015-01-01

    A general method for reliability evaluation of multistate network is using minimal path vectors. A minimal path (MP) vector to system state d is called a d-MP. Most reported works on generating d-MPs are for a particular d value. However, if all d-MPs for all possible integer d values are required, we need to call such methods multiple times with respect to all d values. A more efficient method is desirable to generate all d-MPs. In this paper, we develop a recursive algorithm based on breadth-first search to search for all the d-MPs for all possible d values. The relationships among d-MPs for different d levels are revealed. Each d-MP candidate can be generated by a combination of one (d-1)-MP and the vector form of one binary minimal path. Thus, we can use binary MPs as building blocks to generate 2-MP candidates, and use 2-MPs and binary MPs as building blocks to generate 3-MP candidates … and so forth. When the d-MPs with respect to the maximum d value have been found, all the d-MPs for all possible d values are obtained. A heuristic for pre-processing the MPs is proposed to improve the efficiency of the algorithm. Through computational experiments, it is found that the proposed algorithm is more efficient than existing algorithms for finding all d-MPs for all possible d values. In addition, we show that the proposed algorithm can also be used to generate a subset of d-MPs for all or some d values given a subset of MPs. The generated subset of d-MPs can be used for lower reliability bound evaluation. - Highlights: • The relationships among d-MPs for different d levels are revealed. • An efficient algorithm is developed to search for all d-MPs for all d levels. • A heuristic for pre-processing the MPs is proposed to improve the efficiency. • The computational efficiency of the algorithm is investigated. • A method to search for subsets of d-MPs is proposed for reliability bounding

  3. Generating functional for Donaldson invariants and operator algebra in topological D=4 Yang-Mills theory

    International Nuclear Information System (INIS)

    Johansen, A.A.

    1992-01-01

    It is shown, that under the certain constraints the generating functional for the Donaldson invariants in the D=4 topological Yang-Mills theory can be interpreted as a partition function for the renormalizable theory. 20 refs

  4. Partial breaking of N = 1, D = 10 supersymmetry

    International Nuclear Information System (INIS)

    Bellucci, S.

    1999-01-01

    In this paper is described the spontaneous partial breaking of N =1, D =10 supersymmetry to N = (1, 0), d = 6 and its dimensionally-reduced versions in the framework of nonlinear realizations. The basic Goldstone superfield is N = (1, 0), d = 6 hyper multiplet superfield satisfying a nonlinear generalization of the standard hyper multiplet constraint. It is here interpreted the generalized constraint as the manifestly world volume supersymmetric form of equations of motion of the type 1 super 5-brane in D 10. The related issues here addressed are a possible existence of brane extension of off-shell hyper multiplet actions, the possibility to utilize vector N = (1, 0), d =6 supermultiplet as the Goldstone one, and the description of 1/4 breaking of N =1, D = 11 supersymmetry

  5. Biomaterials-based 3D cell printing for next-generation therapeutics and diagnostics.

    Science.gov (United States)

    Jang, Jinah; Park, Ju Young; Gao, Ge; Cho, Dong-Woo

    2018-02-01

    Building human tissues via 3D cell printing technology has received particular attention due to its process flexibility and versatility. This technology enables the recapitulation of unique features of human tissues and the all-in-one manufacturing process through the design of smart and advanced biomaterials and proper polymerization techniques. For the optimal engineering of tissues, a higher-order assembly of physiological components, including cells, biomaterials, and biomolecules, should meet the critical requirements for tissue morphogenesis and vascularization. The convergence of 3D cell printing with a microfluidic approach has led to a significant leap in the vascularization of engineering tissues. In addition, recent cutting-edge technology in stem cells and genetic engineering can potentially be adapted to the 3D tissue fabrication technique, and it has great potential to shift the paradigm of disease modeling and the study of unknown disease mechanisms required for precision medicine. This review gives an overview of recent developments in 3D cell printing and bioinks and provides technical requirements for engineering human tissues. Finally, we propose suggestions on the development of next-generation therapeutics and diagnostics. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Generation of Functional Thyroid Tissue Using 3D-Based Culture of Embryonic Stem Cells.

    Science.gov (United States)

    Antonica, Francesco; Kasprzyk, Dominika Figini; Schiavo, Andrea Alex; Romitti, Mírian; Costagliola, Sabine

    2017-01-01

    During the last decade three-dimensional (3D) cultures of pluripotent stem cells have been intensively used to understand morphogenesis and molecular signaling important for the embryonic development of many tissues. In addition, pluripotent stem cells have been shown to be a valid tool for the in vitro modeling of several congenital or chronic human diseases, opening new possibilities to study their physiopathology without using animal models. Even more interestingly, 3D culture has proved to be a powerful and versatile tool to successfully generate functional tissues ex vivo. Using similar approaches, we here describe a protocol for the generation of functional thyroid tissue using mouse embryonic stem cells and give all the details and references for its characterization and analysis both in vitro and in vivo. This model is a valid approach to study the expression and the function of genes involved in the correct morphogenesis of thyroid gland, to elucidate the mechanisms of production and secretion of thyroid hormones and to test anti-thyroid drugs.

  7. MART-10, a New Generation of Vitamin D Analog, Is More Potent than 1α,25-Dihydroxyvitamin D3 in Inhibiting Cell Proliferation and Inducing Apoptosis in ER+ MCF-7 Breast Cancer Cells

    Directory of Open Access Journals (Sweden)

    Kun-Chun Chiang

    2012-01-01

    Full Text Available Hormone antagonist therapy for estrogen receptor positive (ER+ breast cancer patients post radical surgery and radiation therapy has a poor prognosis and also causes bone loss. 1α,25-dihydroxyvitamin D3 [1α,25(OH2D3] is a potent antitumor agent in pre-clinical studies, but caused hypercalcemia when its effective antitumor doses were used. Therefore, we investigated the effects of a less-calcemic 1α,25(OH2D3 analog, 19-nor-2α-(3-hydroxypropyl-1α,25-dihydroxyvitamin D3 (MART-10, on ER+MCF-7 cells. We demonstrate that MART-10 is 500- to 1000-fold more potent than 1α,25(OH2D3 in inhibiting cell growth in a dose- and time-dependent manner. MART-10 is also much more potent in arresting MCF-7cell cycle progression at G0/G1 phase as compared to 1α,25(OH2D3, possibly mediated by a greater induction of p21 and p27 expression. Moreover, MART-10 is more active than 1α,25(OH2D3 in causing cell apoptosis, likely through a higher BAX/Bcl expression ratio and the subsequent cytochrome C release from mitochondria to cytosol. Based on our in vitro findings, MART-10 could be a promising vitamin D analog for the potential treatment of breast cancer, for example, ER+ patients, to decrease the tumor relapse rate and the side effect on bone caused by antihormone regimens. Thus, further in vivo animal study is warranted.

  8. Study by Monte Carlo methods of an explosives detection system made up with a D-D neutron generator and NaI(Tl) gamma detectors.

    Science.gov (United States)

    Cevallos Robalino, Lenin E; García Fernández, Gonzalo Felipe; Gallego, Eduardo; Guzmán-García, Karen A; Vega-Carrillo, Hector Rene

    2018-02-17

    Detection of hidden explosives is of utmost importance for homeland security. Several configurations of an Explosives Detection System (EDS) to intercept hidden threats, made up with a Deuterium-Deuterium (D-D) compact neutron generator and NaI (Tl) scintillation detectors, have been evaluated using MCNP6 code. The system's response to various samples of explosives, such as RDX and Ammonium Nitrate, is analysed. The D-D generator is able to produce fast neutrons with 2.5 MeV energy in a maximum yield of 10 10 n/s. It is surrounded by high-density polyethylene to thermalize the fast neutrons and to optimize interactions with the sample inspected, whose emission of gamma rays gives a characteristic spectrum of the elements that constitute it. This procedure allows to determine its chemical composition and to identify the type of substance. The necessary shielding is evaluated to estimate its thicknesses depending on the admissible dose of operation, using lead and polyethylene. The results show that its functionality is promising in the field of national security for explosives inspection. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions.

    Science.gov (United States)

    Pandalaneni, Sravan; Karuppiah, Vijaykumar; Saleem, Muhammad; Haynes, Lee P; Burgoyne, Robert D; Mayans, Olga; Derrick, Jeremy P; Lian, Lu-Yun

    2015-07-24

    Neuronal calcium sensor-1 (NCS-1) is the primordial member of the neuronal calcium sensor family of EF-hand Ca(2+)-binding proteins. It interacts with both the G-protein-coupled receptor (GPCR) dopamine D2 receptor (D2R), regulating its internalization and surface expression, and the cognate kinases GRK1 and GRK2. Determination of the crystal structures of Ca(2+)/NCS-1 alone and in complex with peptides derived from D2R and GRK1 reveals that the differential recognition is facilitated by the conformational flexibility of the C-lobe-binding site. We find that two copies of the D2R peptide bind within the hydrophobic crevice on Ca(2+)/NCS-1, but only one copy of the GRK1 peptide binds. The different binding modes are made possible by the C-lobe-binding site of NCS-1, which adopts alternative conformations in each complex. C-terminal residues Ser-178-Val-190 act in concert with the flexible EF3/EF4 loop region to effectively form different peptide-binding sites. In the Ca(2+)/NCS-1·D2R peptide complex, the C-terminal region adopts a 310 helix-turn-310 helix, whereas in the GRK1 peptide complex it forms an α-helix. Removal of Ser-178-Val-190 generated a C-terminal truncation mutant that formed a dimer, indicating that the NCS-1 C-terminal region prevents NCS-1 oligomerization. We propose that the flexible nature of the C-terminal region is essential to allow it to modulate its protein-binding sites and adapt its conformation to accommodate both ligands. This appears to be driven by the variability of the conformation of the C-lobe-binding site, which has ramifications for the target specificity and diversity of NCS-1. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  10. Information on the gauge principle from an N=1/2, D=2 supersymmetric model

    International Nuclear Information System (INIS)

    Dias, S.A.; Doria, R.M.; Valle, J.L.M.

    1988-01-01

    The gauge principle does not only work to generate interactions. It potentially yields an abundance of gauge-potential fields transforming under the same local symmetry group. In order to show evidences of this property this work gauge-covariantizes an N = 1/2, D = 2 supersymmetric theory. Then, by relaxing the so-called conventional constraint, a second gauge-potential field naturally emerges. (author) [pt

  11. Automatic Generation of Building Models with Levels of Detail 1-3

    Science.gov (United States)

    Nguatem, W.; Drauschke, M.; Mayer, H.

    2016-06-01

    We present a workflow for the automatic generation of building models with levels of detail (LOD) 1 to 3 according to the CityGML standard (Gröger et al., 2012). We start with orienting unsorted image sets employing (Mayer et al., 2012), we compute depth maps using semi-global matching (SGM) (Hirschmüller, 2008), and fuse these depth maps to reconstruct dense 3D point clouds (Kuhn et al., 2014). Based on planes segmented from these point clouds, we have developed a stochastic method for roof model selection (Nguatem et al., 2013) and window model selection (Nguatem et al., 2014). We demonstrate our workflow up to the export into CityGML.

  12. Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination.

    Science.gov (United States)

    Lenden Hasse, Hélène; Lescale, Chloé; Bianchi, Joy J; Yu, Wei; Bedora-Faure, Marie; Deriano, Ludovic

    2017-12-01

    Antigen receptor gene assembly is accomplished in developing lymphocytes by the V(D)J recombination reaction, which can be separated into two steps: DNA cleavage by the recombination-activating gene (RAG) nuclease and joining of DNA double strand breaks (DSBs) by components of the nonhomologous end joining (NHEJ) pathway. Deficiencies for NHEJ factors can result in immunodeficiency and a propensity to accumulate genomic instability, thus highlighting the importance of identifying all players in this process and deciphering their functions. Bcl2 transgenic v-Abl kinase-transformed pro-B cells provide a pseudo-physiological cellular system to study V(D)J recombination. Treatment of v-Abl/Bcl2 pro-B cells with the Abl kinase inhibitor Imatinib leads to G1 cell cycle arrest, the rapid induction of Rag1/2 gene expression and V(D)J recombination. In this system, the Bcl2 transgene alleviates Imatinib-induced apoptosis enabling the analysis of induced V(D)J recombination. Although powerful, the use of mouse models carrying the Bcl2 transgene for the generation of v-Abl pro-B cell lines is time and money consuming. Here, we describe a method for generating v-Abl/Bcl2 pro-B cell lines from wild type mice and for performing gene knock-out using episomal CRISPR/Cas9 targeting vectors. Using this approach, we generated distinct NHEJ-deficient pro-B cell lines and quantified V(D)J recombination levels in these cells. Furthermore, this methodology can be adapted to generate pro-B cell lines deficient for any gene suspected to play a role in V(D)J recombination, and more generally DSB repair. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  13. 3-D simulations of M9 earthquakes on the Cascadia Megathrust: Key parameters and uncertainty

    Science.gov (United States)

    Wirth, Erin; Frankel, Arthur; Vidale, John; Marafi, Nasser A.; Stephenson, William J.

    2017-01-01

    Geologic and historical records indicate that the Cascadia subduction zone is capable of generating large, megathrust earthquakes up to magnitude 9. The last great Cascadia earthquake occurred in 1700, and thus there is no direct measure on the intensity of ground shaking or specific rupture parameters from seismic recordings. We use 3-D numerical simulations to generate broadband (0-10 Hz) synthetic seismograms for 50 M9 rupture scenarios on the Cascadia megathrust. Slip consists of multiple high-stress drop subevents (~M8) with short rise times on the deeper portion of the fault, superimposed on a background slip distribution with longer rise times. We find a >4x variation in the intensity of ground shaking depending upon several key parameters, including the down-dip limit of rupture, the slip distribution and location of strong-motion-generating subevents, and the hypocenter location. We find that extending the down-dip limit of rupture to the top of the non-volcanic tremor zone results in a ~2-3x increase in peak ground acceleration for the inland city of Seattle, Washington, compared to a completely offshore rupture. However, our simulations show that allowing the rupture to extend to the up-dip limit of tremor (i.e., the deepest rupture extent in the National Seismic Hazard Maps), even when tapering the slip to zero at the down-dip edge, results in multiple areas of coseismic coastal uplift. This is inconsistent with coastal geologic evidence (e.g., buried soils, submerged forests), which suggests predominantly coastal subsidence for the 1700 earthquake and previous events. Defining the down-dip limit of rupture as the 1 cm/yr locking contour (i.e., mostly offshore) results in primarily coseismic subsidence at coastal sites. We also find that the presence of deep subevents can produce along-strike variations in subsidence and ground shaking along the coast. Our results demonstrate the wide range of possible ground motions from an M9 megathrust earthquake in

  14. Dopamine D/sub 2/ and D/sub 1/ receptors: biochemical characterization

    Energy Technology Data Exchange (ETDEWEB)

    Niznik, H B

    1986-01-01

    In order to label dopamine D/sub 2/ receptors reversibly and selectively the potent substituted benzamide neuroleptic, YM-09151-2, was tritium labeled and its binding characteristics to striatal homogenates investigated. (/sup 3/H) YM-09151-2 bound to D/sub 2/ receptors with high affinity in a specific, saturable, reversible and sodium dependent fashion, displaying an appropriate pharmacological D/sub 2/ receptor profile. (/sup 3/H) YM-09151-2 appears to be the ligand of choice for labeling D/sub 2/ receptors since it displays approximately 20-fold lower affinity for serotonergic S/sub 2/ receptors than does (/sup 3/H) spiperone. As an initial step towards the molecular identification of the ligand binding subunit of the striatal D/sub 2/ receptor, photolabile analogues of the substituted benzamide clebopride were synthesized and their reversible and irreversible binding interactions to D/sub 2/ receptors characterized. D/sub 2/ receptor photoinactivation was prevented in a concentration and stereoselective manner by dopaminergic agonists and antagonists. In vivo biodistribution studies with (/sup 125/I) iodoazidoclebopride confirmed the ligand's ability to bind to D/sub 2/ receptor-rich regions and as such, may become a useful tool for the molecular characterization of D/sub 2/ receptor proteins. Digitonin solubilized striatal dopamine D/sub 2/ and D/sub 1/ receptors can be completely separated with full retention of biological activity by steric exclusion High Pressure Liquid Chromatography (HPLC) with corresponding Stokes radii of 7.1 and 5.6 nm.

  15. Electron Thermal Capacity in Plasma Generated at Cavitation Bubble Collapse in D-acetone

    CERN Document Server

    Kostenko, B F

    2004-01-01

    The latest experimental data on nuclear reaction product registration at cavitation bubble collapse in deuterated acetone (C$_3$D$_6$O) still argue in favour of existence of a new possibility to realize the thermonuclear synthesis. Theoretical description based on numerical solution of simultaneous conservation equations for gaseous and liquid phases also confirms this possibility, although it requires further more precise definitions. In particular, description of electron degrees of freedom in very dense nonequilibrium plasma generated at the final stage of bubble collapse needs specification. In the present paper, calculations of electron thermal capacity in the deuterated acetone multiple ionization region at electron temperatures $T_e \\simeq 10^4 $ K and above and compression range $\\rho/\\rho_0 \\simeq 1 \\div 100$ have been fulfilled on the basis of direct numerical solution of equation for chemical potential.

  16. Nested 1D-2D approach for urban surface flood modeling

    Science.gov (United States)

    Murla, Damian; Willems, Patrick

    2015-04-01

    Floods in urban areas as a consequence of sewer capacity exceedance receive increased attention because of trends in urbanization (increased population density and impermeability of the surface) and climate change. Despite the strong recent developments in numerical modeling of water systems, urban surface flood modeling is still a major challenge. Whereas very advanced and accurate flood modeling systems are in place and operation by many river authorities in support of flood management along rivers, this is not yet the case in urban water management. Reasons include the small scale of the urban inundation processes, the need to have very high resolution topographical information available, and the huge computational demands. Urban drainage related inundation modeling requires a 1D full hydrodynamic model of the sewer network to be coupled with a 2D surface flood model. To reduce the computational times, 0D (flood cones), 1D/quasi-2D surface flood modeling approaches have been developed and applied in some case studies. In this research, a nested 1D/2D hydraulic model has been developed for an urban catchment at the city of Gent (Belgium), linking the underground sewer (minor system) with the overland surface (major system). For the overland surface flood modelling, comparison was made of 0D, 1D/quasi-2D and full 2D approaches. The approaches are advanced by considering nested 1D-2D approaches, including infiltration in the green city areas, and allowing the effects of surface storm water storage to be simulated. An optimal nested combination of three different mesh resolutions was identified; based on a compromise between precision and simulation time for further real-time flood forecasting, warning and control applications. Main streets as mesh zones together with buildings as void regions constitute one of these mesh resolution (3.75m2 - 15m2); they have been included since they channel most of the flood water from the manholes and they improve the accuracy of

  17. Generating 3D and 3D-like animations of strongly uneven surface microareas of bloodstains from small series of partially out-of-focus digital SEM micrographs.

    Science.gov (United States)

    Hortolà, Policarp

    2010-01-01

    When dealing with microscopic still images of some kinds of samples, the out-of-focus problem represents a particularly serious limiting factor for the subsequent generation of fully sharp 3D animations. In order to produce fully-focused 3D animations of strongly uneven surface microareas, a vertical stack of six digital secondary-electron SEM micrographs of a human bloodstain microarea was acquired. Afterwards, single combined images were generated using a macrophotography and light microscope image post-processing software. Subsequently, 3D animations of texture and topography were obtained in different formats using a combination of software tools. Finally, a 3D-like animation of a texture-topography composite was obtained in different formats using another combination of software tools. By one hand, results indicate that the use of image post-processing software not concerned primarily with electron micrographs allows to obtain, in an easy way, fully-focused images of strongly uneven surface microareas of bloodstains from small series of partially out-of-focus digital SEM micrographs. On the other hand, results also indicate that such small series of electron micrographs can be utilized for generating 3D and 3D-like animations that can subsequently be converted into different formats, by using certain user-friendly software facilities not originally designed for use in SEM, that are easily available from Internet. Although the focus of this study was on bloodstains, the methods used in it well probably are also of relevance for studying the surface microstructures of other organic or inorganic materials whose sharp displaying is difficult of obtaining from a single SEM micrograph.

  18. Statistical parameters of random heterogeneity estimated by analysing coda waves based on finite difference method

    Science.gov (United States)

    Emoto, K.; Saito, T.; Shiomi, K.

    2017-12-01

    Short-period (2 s) seismograms. We found that the energy of the coda of long-period seismograms shows a spatially flat distribution. This phenomenon is well known in short-period seismograms and results from the scattering by small-scale heterogeneities. We estimate the statistical parameters that characterize the small-scale random heterogeneity by modelling the spatiotemporal energy distribution of long-period seismograms. We analyse three moderate-size earthquakes that occurred in southwest Japan. We calculate the spatial distribution of the energy density recorded by a dense seismograph network in Japan at the period bands of 8-16 s, 4-8 s and 2-4 s and model them by using 3-D finite difference (FD) simulations. Compared to conventional methods based on statistical theories, we can calculate more realistic synthetics by using the FD simulation. It is not necessary to assume a uniform background velocity, body or surface waves and scattering properties considered in general scattering theories. By taking the ratio of the energy of the coda area to that of the entire area, we can separately estimate the scattering and the intrinsic absorption effects. Our result reveals the spectrum of the random inhomogeneity in a wide wavenumber range including the intensity around the corner wavenumber as P(m) = 8πε2a3/(1 + a2m2)2, where ε = 0.05 and a = 3.1 km, even though past studies analysing higher-frequency records could not detect the corner. Finally, we estimate the intrinsic attenuation by modelling the decay rate of the energy. The method proposed in this study is suitable for quantifying the statistical properties of long-wavelength subsurface random inhomogeneity, which leads the way to characterizing a wider wavenumber range of spectra, including the corner wavenumber.

  19. Generation of Ground Truth Datasets for the Analysis of 3d Point Clouds in Urban Scenes Acquired via Different Sensors

    Science.gov (United States)

    Xu, Y.; Sun, Z.; Boerner, R.; Koch, T.; Hoegner, L.; Stilla, U.

    2018-04-01

    In this work, we report a novel way of generating ground truth dataset for analyzing point cloud from different sensors and the validation of algorithms. Instead of directly labeling large amount of 3D points requiring time consuming manual work, a multi-resolution 3D voxel grid for the testing site is generated. Then, with the help of a set of basic labeled points from the reference dataset, we can generate a 3D labeled space of the entire testing site with different resolutions. Specifically, an octree-based voxel structure is applied to voxelize the annotated reference point cloud, by which all the points are organized by 3D grids of multi-resolutions. When automatically annotating the new testing point clouds, a voting based approach is adopted to the labeled points within multiple resolution voxels, in order to assign a semantic label to the 3D space represented by the voxel. Lastly, robust line- and plane-based fast registration methods are developed for aligning point clouds obtained via various sensors. Benefiting from the labeled 3D spatial information, we can easily create new annotated 3D point clouds of different sensors of the same scene directly by considering the corresponding labels of 3D space the points located, which would be convenient for the validation and evaluation of algorithms related to point cloud interpretation and semantic segmentation.

  20. Seismic waves in 3-D: from mantle asymmetries to reliable seismic hazard assessment

    Science.gov (United States)

    Panza, Giuliano F.; Romanelli, Fabio

    2014-10-01

    A global cross-section of the Earth parallel to the tectonic equator (TE) path, the great circle representing the equator of net lithosphere rotation, shows a difference in shear wave velocities between the western and eastern flanks of the three major oceanic rift basins. The low-velocity layer in the upper asthenosphere, at a depth range of 120 to 200 km, is assumed to represent the decoupling between the lithosphere and the underlying mantle. Along the TE-perturbed (TE-pert) path, a ubiquitous LVZ, about 1,000-km-wide and 100-km-thick, occurs in the asthenosphere. The existence of the TE-pert is a necessary prerequisite for the existence of a continuous global flow within the Earth. Ground-shaking scenarios were constructed using a scenario-based method for seismic hazard analysis (NDSHA), using realistic and duly validated synthetic time series, and generating a data bank of several thousands of seismograms that account for source, propagation, and site effects. Accordingly, with basic self-organized criticality concepts, NDSHA permits the integration of available information provided by the most updated seismological, geological, geophysical, and geotechnical databases for the site of interest, as well as advanced physical modeling techniques, to provide a reliable and robust background for the development of a design basis for cultural heritage and civil infrastructures. Estimates of seismic hazard obtained using the NDSHA and standard probabilistic approaches are compared for the Italian territory, and a case-study is discussed. In order to enable a reliable estimation of the ground motion response to an earthquake, three-dimensional velocity models have to be considered, resulting in a new, very efficient, analytical procedure for computing the broadband seismic wave-field in a 3-D anelastic Earth model.

  1. BETHSY 9.1b Test Calculation with TRACE Using 3D Vessel Component

    International Nuclear Information System (INIS)

    Berar, O.; Prosek, A.

    2012-01-01

    Recently, several advanced multidimensional computational tools for simulating reactor system behaviour during real and hypothetical transient scenarios were developed. One of such advanced, best-estimate reactor systems codes is TRAC/RELAP Advanced Computational Engine (TRACE), developed by the U.S. Nuclear Regulatory Commission. The advanced TRACE comes with a graphical user interface called SNAP (Symbolic Nuclear Analysis Package). It is intended for pre- and post-processing, running codes, RELAP5 to TRACE input deck conversion, input deck database generation etc. The TRACE code is still not fully development and it will have all the capabilities of RELAP5. The purpose of the present study was therefore to assess the 3D capability of the TRACE on BETHSY 9.1b test. The TRACE input deck was semi-converted (using SNAP and manual corrections) from the RELAP5 input deck. The 3D fluid dynamics within reactor vessel was modelled and compared to 1D fluid dynamics. The 3D calculation was compared both to TRACE 1D calculation and RELAP5 calculation. Namely, the geometry used in TRACE is basically the same, what gives very good basis for the comparison of the codes. The only exception is 3D reactor vessel model in case of TRACE 3D calculation. The TRACE V5.0 Patch 1 and RELAP5/MOD3.3 Patch 4 were used for calculations. The BETHSY 9.1b test (International Standard Problem no. 27 or ISP-27) was 5.08 cm equivalent diameter cold leg break without high pressure safety injection and with delayed ultimate procedure. BETHSY facility was a 3-loop replica of a 900 MWe FRAMATOME pressurized water reactor. For better presentation of the calculated physical phenomena and processes, an animation model using SNAP was developed. In general, the TRACE 3D code calculation is in good agreement with the BETHSY 9.1b test. The TRACE 3D calculation results are as good as or better than the RELAP5 calculated results. Also, the TRACE 3D calculation is not significantly different from TRACE 1D

  2. 3D Ground-Motion Simulations for Magnitude 9 Earthquakes on the Cascadia Megathrust: Sedimentary Basin Amplification, Rupture Directivity, and Ground-Motion Variability

    Science.gov (United States)

    Frankel, A. D.; Wirth, E. A.; Marafi, N.; Vidale, J. E.; Stephenson, W. J.

    2017-12-01

    We have produced broadband (0-10 Hz) synthetic seismograms for Mw 9 earthquakes on the Cascadia subduction zone by combining synthetics from 3D finite-difference simulations at low frequencies (≤ 1 Hz) and stochastic synthetics at high frequencies (≥ 1 Hz). These synthetic ground motions are being used to evaluate building response, liquefaction, and landslides, as part of the M9 Project of the University of Washington, in collaboration with the U.S. Geological Survey. The kinematic rupture model is composed of high stress drop sub-events with Mw 8, similar to those observed in the Mw 9.0 Tohoku, Japan and Mw 8.8 Maule, Chile earthquakes, superimposed on large background slip with lower slip velocities. The 3D velocity model is based on active and passive-source seismic tomography studies, seismic refraction and reflection surveys, and geologic constraints. The Seattle basin portion of the model has been validated by simulating ground motions from local earthquakes. We have completed 50 3D simulations of Mw 9 earthquakes using a variety of hypocenters, slip distributions, sub-event locations, down-dip limits of rupture, and other parameters. For sites not in deep sedimentary basins, the response spectra of the synthetics for 0.1-6.0 s are similar, on average, to the values from the BC Hydro ground motion prediction equations (GMPE). For periods of 7-10 s, the synthetic response spectra exceed these GMPE, partially due to the shallow dip of the plate interface. We find large amplification factors of 2-5 for response spectra at periods of 1-10 s for locations in the Seattle and Tacoma basins, relative to sites outside the basins. This amplification depends on the direction of incoming waves and rupture directivity. The basin amplification is caused by surface waves generated at basin edges from incoming S-waves, as well as amplification and focusing of S-waves and surface waves by the 3D basin structure. The inter-event standard deviation of response spectral

  3. On the Generation of Transport Suppression Barriers by Externally Driven Alfven Waves in D-Shaped, Low Aspect Ratio Tokamaks

    International Nuclear Information System (INIS)

    Bruma, C.; Cuperman, S.

    2003-01-01

    We investigate quantitatively the possibility of turbulence suppression through the generation of transport barriers in pre-heated low aspect ratio tokamaks (LARTs) by the sheared electric fields generated by externally driven rf waves in the frequency range ω A ≅ ci (ω A and ω ci are, respectively, Alfven and ion cyclotron frequencies). To this aim the following sequential steps are followed: (1) Solutions of the resistive two-fluid model full wave equation for a realistic LART configuration (D-shape cross-section and aspect ratio, R/a ∼> 1; as well as suitably located low field side, LFS, antenna) upon using a quite general dielectric tensor operator; (2) Calculation of the ponderomotive forces and their magnetic surface averages; (3) Solution of a strongly non-linear differential equation for the quasi-stationary radial electric field, including the particle orbit squeezing effects, based on the results of steps (1) and (2); and (4) Calculation of the radial flow shear, S perpend ; for both banana and potato collisional regimes

  4. T-duality of Green-Schwarz superstrings on AdS_d×S"d×M"1"0"−"2"d

    International Nuclear Information System (INIS)

    Abbott, Michael C.; Murugan, Jeff; Penati, Silvia; Pittelli, Antonio; Sorokin, Dmitri; Sundin, Per; Tarrant, Justine; Wolf, Martin; Wulff, Linus

    2015-01-01

    We verify the self-duality of Green-Schwarz supercoset sigma models on AdS_d×S"d backgrounds (d=2,3,5) under combined bosonic and fermionic T-dualities without gauge fixing kappa symmetry. We also prove this property for superstrings on AdS_d×S"d×S"d(d=2,3) described by supercoset sigma models with the isometries governed by the exceptional Lie supergroups D(2,1;α) (d=2) and D(2,1;α)×D(2,1;α) (d=3), which requires an additional T-dualisation along one of the spheres. Then, by taking into account the contribution of non-supercoset fermionic modes (up to the second order), we provide evidence for the T-self-duality of the complete type IIA and IIB Green-Schwarz superstring theory on AdS_d×S"d×T"1"0"−"2"d (d=2,3) backgrounds with Ramond-Ramond fluxes. Finally, applying the Buscher-like rules to T-dualising supergravity fields, we prove the T-self-duality of the whole class of the AdS_d×S"d×M"1"0"−"2"d superbackgrounds with Ramond-Ramond fluxes in the context of supergravity.

  5. Detailed study of spontaneous rotation generation in diverted H-mode plasma using the full-f gyrokinetic code XGC1

    Science.gov (United States)

    Seo, Janghoon; Chang, C. S.; Ku, S.; Kwon, J. M.; Yoon, E. S.

    2013-10-01

    The Full-f gyrokinetic code XGC1 is used to study the details of toroidal momentum generation in H-mode plasma. Diverted DIII-D geometry is used, with Monte Carlo neutral particles that are recycled at the limiter wall. Nonlinear Coulomb collisions conserve particle, momentum, and energy. Gyrokinetic ions and adiabatic electrons are used in the present simulation to include the effects from ion gyrokinetic turbulence and neoclassical physics, under self-consistent radial electric field generation. Ion orbit loss physics is automatically included. Simulations show a strong co-Ip flow in the H-mode layer at outside midplane, similarly to the experimental observation from DIII-D and ASDEX-U. The co-Ip flow in the edge propagates inward into core. It is found that the strong co-Ip flow generation is mostly from neoclassical physics. On the other hand, the inward momentum transport is from turbulence physics, consistently with the theory of residual stress from symmetry breaking. Therefore, interaction between the neoclassical and turbulence physics is a key factor in the spontaneous momentum generation.

  6. First-order P-wave ray synthetic seismograms in inhomogeneous, weakly anisotropic, layered media

    Czech Academy of Sciences Publication Activity Database

    Pšenčík, Ivan; Farra, V.

    2014-01-01

    Roč. 198, č. 1 (2014), s. 298-307 ISSN 0956-540X R&D Projects: GA ČR(CZ) GAP210/11/0117 Institutional support: RVO:67985530 Keywords : body waves * seismic anisotropy * wave propagation Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 2.724, year: 2013

  7. Automatic generation of medium-detailed 3D models of buildings based on CAD data

    NARCIS (Netherlands)

    Dominguez-Martin, B.; Van Oosterom, P.; Feito-Higueruela, F.R.; Garcia-Fernandez, A.L.; Ogayar-Anguita, C.J.

    2015-01-01

    We present the preliminary results of a work in progress which aims to obtain a software system able to automatically generate a set of diverse 3D building models with a medium level of detail, that is, more detailed that a mere parallelepiped, but not as detailed as a complete geometric

  8. 26 CFR 1.1503(d)-0 - Table of contents.

    Science.gov (United States)

    2010-04-01

    ... section lists the captions contained in §§ 1.1503(d)-1 through 1.1503(d)-8. § 1.1503(d)-1Definitions and... of a dual consolidated loss used in other taxable years. (5) Reconstituted net operating losses. (d...) Foreign currency gain or loss recognized under section 987. (vi) Recapture of dual consolidated loss. (d...

  9. The analysis of historical seismograms: an important tool for seismic hazard assessment. Case histories from French and Italian earthquakes; L'analyse des sismogrammes historiques: un outil important pour l'evaluation de l'alea sismique. Etudes de cas de tremblements de terre en France et en Italie

    Energy Technology Data Exchange (ETDEWEB)

    Pino, N.A. [Istituto Nazionale di Geofisica e Vulcanologia, Osservatorio Vesuviano, Via Diocleziano 328, 80124 Napoli (Italy)

    2011-06-15

    Seismic hazard assessment relies on the knowledge of the source characteristics of past earthquakes. Unfortunately, seismic waveform analysis, representing the most powerful tool for the investigation of earthquake source parameters, is only possible for events occurred in the last 100-120 years, i.e., since seismographs with known response function were developed. Nevertheless, during this time significant earthquakes have been recorded by such instruments and today, also thanks to technological progress, these data can be recovered and analysed by means of modern techniques. In this paper, aiming at giving a general sketch of possible analyses and attainable results in historical seismogram studies, I briefly describe the major difficulties in processing the original waveforms and present a review of the results that I obtained from previous seismogram analysis of selected significant historical earthquakes occurred during the first decades of the 20. century, including (A) the December 28, 1908, Messina straits (southern Italy), (B) the June 11, 1909, Lambesc (southern France) - both of which are the strongest ever recorded instrumentally in their respective countries - and (C) the July 13, 1930, Irpinia (southern Italy) events. For these earthquakes, the major achievements are represented by the assessment of the seismic moment (A, B, C), the geometry and kinematics of faulting (B, C), the fault length and an approximate slip distribution (A, C). The source characteristics of the studied events have also been interpreted in the frame of the tectonic environment active in the respective region of interest. In spite of the difficulties inherent to the investigation of old seismic data, these results demonstrate the invaluable and irreplaceable role of historical seismogram analysis in defining the local seismo-genic potential and, ultimately, for assessing the seismic hazard. The retrieved information is crucial in areas where important civil engineering works

  10. BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells

    International Nuclear Information System (INIS)

    Nakuci, Enkeleda; Mahner, Sven; DiRenzo, James; ElShamy, Wael M.

    2006-01-01

    The regulator of cell cycle progression, cyclin D1, is up-regulated in breast cancer cells; its expression is, in part, dependent on ERα signaling. However, many ERα-negative tumors and tumor cell lines (e.g., SKBR3) also show over-expression of cyclin D1. This suggests that, in addition to ERα signaling, cyclin D1 expression is under the control of other signaling pathways; these pathways may even be over-expressed in the ERα-negative cells. We previously noticed that both ERα-positive and -negative cell lines over-express BRCA1-IRIS mRNA and protein. Furthermore, the level of over-expression of BRCA1-IRIS in ERα-negative cell lines even exceeded its over-expression level in ERα-positive cell lines. In this study, we show that: (1) BRCA1-IRIS forms complex with two of the nuclear receptor co-activators, namely, SRC1 and SRC3 (AIB1) in an ERα-independent manner. (2) BRCA1-IRIS alone, or in connection with co-activators, is recruited to the cyclin D1 promoter through its binding to c-Jun/AP1 complex; this binding activates the cyclin D1 expression. (3) Over-expression of BRCA1-IRIS in breast cells over-activates JNK/c-Jun; this leads to the induction of cyclin D1 expression and cellular proliferation. (4) BRCA1-IRIS activation of JNK/c-Jun/AP1 appears to account for this, because in cells that were depleted from BRCA1-IRIS, JNK remained inactive. However, depletion of SRC1 or SRC3 instead reduced c-Jun expression. Our data suggest that this novel signaling pathway links BRCA1-IRIS to cellular proliferation through c-Jun/AP1 nuclear pathway; finally, this culminates in the increased expression of the cyclin D1 gene

  11. Development of specific dopamine D-1 agonists and antagonists

    International Nuclear Information System (INIS)

    Sakolchai, S.

    1987-01-01

    To develop potentially selective dopamine D-1 agonists and to investigate on the structural requirement for D-1 activity, the derivatives of dibenzocycloheptadiene are synthesized and pharmacologically evaluated. The target compounds are 5-aminomethyl-10,11-dihydro-1,2-dihydroxy-5H-dibenzo[a,d]cycloheptene hydrobromide 10 and 9,10-dihydroxy-1,2,3,7,8,12b-hexahydrobenzo[1,2]cyclohepta[3,4,5d,e]isoquinoline hydrobromide 11. In a dopamine-sensitive rat retinal adenylate cyclase assay, a model for D-1 activity, compound 10 is essentially inert for both agonist and antagonist activity. In contrast, compound 11 is approximately equipotent to dopamine in activation of the D-1 receptor. Based on radioligand and binding data, IC 50 of compound 11 for displacement of 3 H-SCH 23390, a D-1 ligand, is about 7 fold less than that for displacement of 3 H-spiperone, a D-2 ligand. These data indicate that compound 11 is a potent selective dopamine D-1 agonist. This study provides a new structural class of dopamine D-1 acting agent: dihydroxy-benzocycloheptadiene analog which can serve as a lead compound for further drug development and as a probe for investigation on the nature of dopamine D-1 receptor

  12. The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling.

    Directory of Open Access Journals (Sweden)

    Christiane Desel

    Full Text Available Successful vaccination against intracellular pathogens requires the generation of cellular immune responses. Trehalose-6,6-dibehenate (TDB, the synthetic analog of the mycobacterial cord factor trehalose-6,6-dimycolate (TDM, is a potent adjuvant inducing strong Th1 and Th17 immune responses. We previously identified the C-type lectin Mincle as receptor for these glycolipids that triggers the FcRγ-Syk-Card9 pathway for APC activation and adjuvanticity. Interestingly, in vivo data revealed that the adjuvant effect was not solely Mincle-dependent but also required MyD88. Therefore, we dissected which MyD88-dependent pathways are essential for successful immunization with a tuberculosis subunit vaccine. We show here that antigen-specific Th1/Th17 immune responses required IL-1 receptor-mediated signals independent of IL-18 and IL-33-signaling. ASC-deficient mice had impaired IL-17 but intact IFNγ responses, indicating partial independence of TDB adjuvanticity from inflammasome activation. Our data suggest that the glycolipid adjuvant TDB triggers Mincle-dependent IL-1 production to induce MyD88-dependent Th1/Th17 responses in vivo.

  13. Investigation of reflood models by coupling REFLA-1D and multi-loop system model

    International Nuclear Information System (INIS)

    Sugimoto, Jun; Murao, Yoshio

    1983-09-01

    A system analysis code REFLA-1DS was developed by coupling reflood analysis code REFLA-1D and a multi-loop primary system model. The reflood models in the code were investigated for the development of the integral system analysis code. The REFLA-1D, which was developed with the small scale reflood experiment at JAERI, consists of one-dimensional core model and a primary system model with a constant loop resistance. The multi-loop primary system model was developed with the Cylindrical Core Test Facility of JAERI's large scale reflood tests. The components modeled in the code are the upper plenum, the steam generator, the coolant pump, the ECC injection port, the downcomer and the broken cold leg nozzle. The coupling between the two models in REFLA-1DS is accomplished by applying the equivalent flow resistance calculated with the multiloop model to the REFLA-1D. The characteristics of the code is its simplicity of the system model and the solution method which enables the fast running and the easy reflood analysis for the further model development. A fairly good agreement was obtained with the results of the Cylindrical Core Test Facility for the calculated water levels in the downcomer, the core and the upper plenum. A qualitatively good agreement was obtained concerning the parametric effects of the system pressure, the ECC flow rate and the initial clad temperature. Needs for further code improvements of the models, however, were pointed out. These include the problem concerning the generation rate of the steam and water droplets in the core in an early period, the effect of the flow oscillation on the core cooling, the heat release from the downcomer wall, and the stable system calculation. (author)

  14. Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia.

    Science.gov (United States)

    Farré, Daniel; Muñoz, Ana; Moreno, Estefanía; Reyes-Resina, Irene; Canet-Pons, Júlia; Dopeso-Reyes, Iria G; Rico, Alberto J; Lluís, Carme; Mallol, Josefa; Navarro, Gemma; Canela, Enric I; Cortés, Antonio; Labandeira-García, José L; Casadó, Vicent; Lanciego, José L; Franco, Rafael

    2015-12-01

    Radioligand binding assays to rat striatal dopamine D1 receptors showed that brain lateralization of the dopaminergic system were not due to changes in expression but in agonist affinity. D1 receptor-mediated striatal imbalance resulted from a significantly higher agonist affinity in the left striatum. D1 receptors heteromerize with dopamine D3 receptors, which are considered therapeutic targets for dyskinesia in parkinsonian patients. Expression of both D3 and D1-D3 receptor heteromers were increased in samples from 6-hydroxy-dopamine-hemilesioned rats rendered dyskinetic by treatment with 3, 4-dihydroxyphenyl-L-alanine (L-DOPA). Similar findings were obtained using striatal samples from primates. Radioligand binding studies in the presence of a D3 agonist led in dyskinetic, but not in lesioned or L-DOPA-treated rats, to a higher dopamine sensitivity. Upon D3-receptor activation, the affinity of agonists for binding to the right striatal D1 receptor increased. Excess dopamine coming from L-DOPA medication likely activates D3 receptors thus making right and left striatal D1 receptors equally responsive to dopamine. These results show that dyskinesia occurs concurrently with a right/left striatal balance in D1 receptor-mediated neurotransmission.

  15. Test-retest measurements of dopamine D{sub 1}-type receptors using simultaneous PET/MRI imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kaller, Simon; Patt, Marianne; Becker, Georg-Alexander; Luthardt, Julia; Meyer, Philipp M.; Werner, Peter; Barthel, Henryk; Bresch, Anke; Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Rullmann, Michael [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig (Germany); Girbardt, Johanna [Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig (Germany); Fritz, Thomas H. [Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig (Germany); University of Gent, Institute for Psychoacoustics and Electronic Music (IPEM), Ghent (Belgium); Hesse, Swen [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Leipzig University Medical Centre, Integrated Research and Treatment Centre (IFB) Adiposity Diseases, Leipzig (Germany)

    2017-06-15

    The role of dopamine D{sub 1}-type receptor (D{sub 1}R)-expressing neurons in the regulation of motivated behavior and reward prediction has not yet been fully established. As a prerequisite for future research assessing D{sub 1}-mediated neuronal network regulation using simultaneous PET/MRI and D{sub 1}R-selective [{sup 11}C]SCH23390, this study investigated the stability of central D{sub 1}R measurements between two independent PET/MRI sessions under baseline conditions. Thirteen healthy volunteers (7 female, age 33 ± 13 yrs) underwent 90-min emission scans, each after 90-s bolus injection of 486 ± 16 MBq [{sup 11}C]SCH23390, on two separate days within 2-4 weeks using a PET/MRI system. Parametric images of D{sub 1}R distribution volume ratio (DVR) and binding potential (BP{sub ND}) were generated by a multi-linear reference tissue model with two parameters and the cerebellar cortex as receptor-free reference region. Volume-of-interest (VOI) analysis was performed with manual VOIs drawn on consecutive transverse MRI slices for brain regions with high and low D{sub 1}R density. The DVR varied from 2.5 ± 0.3 to 2.9 ± 0.5 in regions with high D{sub 1}R density (e.g. the head of the caudate) and from 1.2 ± 0.1 to 1.6 ± 0.2 in regions with low D{sub 1}R density (e.g. the prefrontal cortex). The absolute variability of the DVR ranged from 2.4% ± 1.3% to 5.1% ± 5.3%, while Bland-Altman analyses revealed very low differences in mean DVR (e.g. 0.013 ± 0.17 for the nucleus accumbens). Intraclass correlation (one-way, random) indicated very high agreement (0.93 in average) for both DVR and BP{sub ND} values. Accordingly, the absolute variability of BP{sub ND} ranged from 7.0% ± 4.7% to 12.5% ± 10.6%; however, there were regions with very low D{sub 1}R content, such as the occipital cortex, with higher mean variability. The test-retest reliability of D{sub 1}R measurements in this study was very high. This was the case not only for D{sub 1}R-rich brain areas, but

  16. Shape-Control of a 0D/1D NaFe0.9Mn0.1PO4 Nano-Complex by Electrospinning

    Science.gov (United States)

    Shin, Mi-Ra; Son, Jong-Tae

    2018-03-01

    NaFePO4 with a maricite structure was one of the most promising candidates for sodium ion batteries (SIBs) due to its advantages of environmental friendly and having low cost. However, it has low electrochemical conductivity and energy density, which impose limitations on its application as commercial cathode materials. In this study, other transition-metal ions such as Mn2+ were substituted into the iron (Fe2+) site in NaFePO4 to increase the surface area and the number of nanofibers in the prepared one-dimensional (1D) nano-sized material with 0D/1D dimensions to enhance the energy density. Also, the 0D/1D NaFe0.9Mn0.1PO4 cathode material has increased electrochemical conductivity because the fiber size was reduced to the nano-scale level by using the electrospinning method in order to decrease the diffusion path of Na-ions. The morphology of the 0D/1D nanofiber was evaluated by Field-emission scanning electron microscope and atomic force microscope analyses. The NaFe0.9Mn0.1PO4 nanofibers had a diameter of approximately 180 nm, while the spherical particle had a diameter 1 μm. The 0D/1D nano-sized cathode material show a discharge capacity of 27 mAhg -1 at a 0.05 C rate within the 2.0 4.5 V voltage range and a low R ct of 110 Ω.

  17. The modulation effects of d-amphetamine and procaine on the spontaneously generated action potentials in the central neuron of snail, Achatina fulica Ferussac.

    Science.gov (United States)

    Lin, Chia-Hsien; Tsai, Ming-Cheng

    2005-05-01

    The modulation effects of d-amphetamine and procaine on the spontaneously generated action potentials were studied on the RP1 central neuron of giant African snails (Achatina fulica Ferussac). Extra-cellular application of d-amphetamine or procaine reversibly elicited bursts of potential (BoP). Prazosin, propranolol, atropine or d-tubocurarine did not alter the BoP elicited by either d-amphetamine or procaine. KT-5720 or H89 (protein kinase A inhibitors) blocked d-amphetamine-elicited BoP, whereas they did not block the procaine-elicited BoP. U73122, neomycin (phospholipase C inhibitors) blocked the procaine-elicited BoP, whereas they did not block the d-amphetamine-elicited BoP in the same neuron. These results suggest that BoP elicited by d-amphetamine or procaine were associated with protein kinase A and phospholipase C activity in the neuron.

  18. Generation of a monoclonal antibody against the glycosylphosphatidylinositol-linked protein Rae-1 using genetically engineered tumor cells.

    Science.gov (United States)

    Hu, Jiemiao; Vien, Long T; Xia, Xueqing; Bover, Laura; Li, Shulin

    2014-02-04

    Although genetically engineered cells have been used to generate monoclonal antibodies (mAbs) against numerous proteins, no study has used them to generate mAbs against glycosylphosphatidylinositol (GPI)-anchored proteins. The GPI-linked protein Rae-1, an NKG2D ligand member, is responsible for interacting with immune surveillance cells. However, very few high-quality mAbs against Rae-1 are available for use in multiple analyses, including Western blotting, immunohistochemistry, and flow cytometry. The lack of high-quality mAbs limits the in-depth analysis of Rae-1 fate, such as shedding and internalization, in murine models. Moreover, currently available screening approaches for identifying high-quality mAbs are excessively time-consuming and costly. We used Rae-1-overexpressing CT26 tumor cells to generate 60 hybridomas that secreted mAbs against Rae-1. We also developed a streamlined screening strategy for selecting the best anti-Rae-1 mAb for use in flow cytometry assay, enzyme-linked immunosorbent assay, Western blotting, and immunostaining. Our cell line-based immunization approach can yield mAbs against GPI-anchored proteins, and our streamlined screening strategy can be used to select the ideal hybridoma for producing such mAbs.

  19. Local magnitude, duration magnitude and seismic moment of Dahshour 1992 earthquakes

    OpenAIRE

    M. F. Abdelwahed; E. M. Abdelrahman; H. M. Hussein; M. M. Dessokey

    2000-01-01

    Local magnitudes ML have been calculated for 56 earthquakes of the Dahshour 1992 sequence using simulated records of the KEG broadband station and the estimated calibration function of the Dahshour area. These were compared with their corresponding values of duration magnitudes obtained from the analog short period seismograms of the HLW station. The local magnitudes M L and the duration magnitudes M D for this region imply a linear relation as follows: M L = 1.2988 (± 0.04) M D – 0.9032 (± 0...

  20. Regulation of 1,25-dihydroxyvitamin D, receptors by [3H]-1,25-dihydroxyvitamin D3 in cultured cells (T-47D): evidence for receptor upregulation

    International Nuclear Information System (INIS)

    Reinhardt, T.A.; Horst, R.L.

    1986-01-01

    The authors examined the effect of 1,25-(OH) 2 D 3 on receptor concentration in cultured cells (T-47D). Two days prior to experiment, cells were fed with RPMI 1640 + 10% serum and 24-32 hours prior to experiment the media was replaced with RPMI 1640 + 25 mM Hepes + 1% serum. [ 3 H]-1,25-(OH) 2 D 3 +/- 100-fold molar excess cold hormone was used to treat the cells. Occupied receptors were measured in freshly prepared cytosols. Total receptors were measured following a 16-hour incubation of cytosols in the presence of 0.6 nM [ 3 H]-1,25-(OH) 2 D 3 +/- 100-fold molar excess of cold hormone at 4 0 C. Treatment of cell cultures for 16-18 hours with 0.5-1.0 nM [ 3 H]-1,25-(OH) 2 D 3 resulted in a 30-40% receptor occupancy by the hormone and a 2- to 3-fold increase in total cell receptor as compared to vehicle-treated controls. Time course studies showed a rapid increase in total receptors up to 16 hours post-treatment in the face of declining receptor occupancy. Actinomycin D blocked the [ 3 H]-1,25-(OH) 2 D 3 -dependent rise in cell receptor. The physiological significance of this receptor upregulation is not known nor is it known whether upregulation results from synthesis of new receptors and/or is the result of the activation of preformed receptors by a inducible activator protein

  1. 26 CFR 1.411(d)-1 - Coordination of vesting and discrimination requirements. [Reserved

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Coordination of vesting and discrimination requirements. [Reserved] 1.411(d)-1 Section 1.411(d)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF... Plans, Etc. § 1.411(d)-1 Coordination of vesting and discrimination requirements. [Reserved] ...

  2. Computer-aided scaffold hopping to identify a novel series of casein kinase 1 delta (CK1d) inhibitors for amyotrophic lateral sclerosis.

    Science.gov (United States)

    Makhuri, Farahnaz Rezaei; Ghasemi, Jahan B

    2015-10-12

    In this study as the first attempt; comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA) and AutoGPA-based 3D-QSAR methods were applied on a set of 47 recently reported Ck1d inhibitors, in order to gain an insight into the structural requirements which providing guidelines for the design of next generation compounds with enhanced bioactivity. The results of 3D-QSAR analyses indicated that hydrophobic and negatively charged groups at 6th position of benzothiazole ring and positively charged and bulky groups at ortho position of phenyl ring are favorable for high activity. Moreover, molecular docking studies with GOLD protocol revealed that this chemical series has two different orientations in CK1d active site: orientation 1, in which the benzothiazole ring of the compounds is the closet to the hydrophobic area created by Ile23 and 37, Ala36 Lys 38, Met80, 82 and Val81, and orientation 2, in which the benzene ring of the compounds is directed toward the hydrophobic center. Molecular docking result of the riluzole, the only drug approved by FDA for amyotrophic lateral sclerosis (ALS), indicated that the orientation 2 is preferred due to the presence of OCF3 group in R(1) situation at 6th position of benzothiazole ring, while with replacement of OCF3 group by CF3, the orientation 1 is observed. At the end, to find similar analogs by virtual screening, a two-stage approach: pharmacophore-based screening using generated AutoGPA-based 3D-QSAR model followed by structure-based virtual screening using molecular docking was employed. Visual inspection of the docking results of virtually obtained hits revealed two different binding orientations, in which compounds with high GOLD fitness scores produced binding modes, which were the same as the one observed in compounds with orientation 1, whereas the binding modes of the structures with low GOLD fitness scores were in agreement with orientation 2. Further, the drug

  3. COMPARISON OF UAS-BASED PHOTOGRAMMETRY SOFTWARE FOR 3D POINT CLOUD GENERATION: A SURVEY OVER A HISTORICAL SITE

    Directory of Open Access Journals (Sweden)

    F. Alidoost

    2017-11-01

    Full Text Available Nowadays, Unmanned Aerial System (UAS-based photogrammetry offers an affordable, fast and effective approach to real-time acquisition of high resolution geospatial information and automatic 3D modelling of objects for numerous applications such as topography mapping, 3D city modelling, orthophoto generation, and cultural heritages preservation. In this paper, the capability of four different state-of-the-art software packages as 3DSurvey, Agisoft Photoscan, Pix4Dmapper Pro and SURE is examined to generate high density point cloud as well as a Digital Surface Model (DSM over a historical site. The main steps of this study are including: image acquisition, point cloud generation, and accuracy assessment. The overlapping images are first captured using a quadcopter and next are processed by different software to generate point clouds and DSMs. In order to evaluate the accuracy and quality of point clouds and DSMs, both visual and geometric assessments are carry out and the comparison results are reported.

  4. Comparison of Uas-Based Photogrammetry Software for 3d Point Cloud Generation: a Survey Over a Historical Site

    Science.gov (United States)

    Alidoost, F.; Arefi, H.

    2017-11-01

    Nowadays, Unmanned Aerial System (UAS)-based photogrammetry offers an affordable, fast and effective approach to real-time acquisition of high resolution geospatial information and automatic 3D modelling of objects for numerous applications such as topography mapping, 3D city modelling, orthophoto generation, and cultural heritages preservation. In this paper, the capability of four different state-of-the-art software packages as 3DSurvey, Agisoft Photoscan, Pix4Dmapper Pro and SURE is examined to generate high density point cloud as well as a Digital Surface Model (DSM) over a historical site. The main steps of this study are including: image acquisition, point cloud generation, and accuracy assessment. The overlapping images are first captured using a quadcopter and next are processed by different software to generate point clouds and DSMs. In order to evaluate the accuracy and quality of point clouds and DSMs, both visual and geometric assessments are carry out and the comparison results are reported.

  5. Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 in human skeletal muscle

    DEFF Research Database (Denmark)

    Treebak, Jonas Thue; Pehmøller, Christian; Kristensen, Jonas Møller

    2014-01-01

    We investigated the phosphorylation signatures of two Rab GTPase activating proteins TBC1D1 and TBC1D4 in human skeletal muscle in response to physical exercise and physiological insulin levels induced by a carbohydrate rich meal using a paired experimental design. Eight healthy male volunteers e...

  6. Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration.

    Science.gov (United States)

    Qi, Y; Liu, H; Daniels, M P; Zhang, G; Xu, H

    2016-02-01

    Mitochondrial AAA (ATPases Associated with diverse cellular Activities) proteases i-AAA (intermembrane space-AAA) and m-AAA (matrix-AAA) are closely related and have major roles in inner membrane protein homeostasis. Mutations of m-AAA proteases are associated with neuromuscular disorders in humans. However, the role of i-AAA in metazoans is poorly understood. We generated a deletion affecting Drosophila i-AAA, dYME1L (dYME1L(del)). Mutant flies exhibited premature aging, progressive locomotor deficiency and neurodegeneration that resemble some key features of m-AAA diseases. dYME1L(del) flies displayed elevated mitochondrial unfolded protein stress and irregular cristae. Aged dYME1L(del) flies had reduced complex I (NADH/ubiquinone oxidoreductase) activity, increased level of reactive oxygen species (ROS), severely disorganized mitochondrial membranes and increased apoptosis. Furthermore, inhibiting apoptosis by targeting dOmi (Drosophila Htra2/Omi) or DIAP1, or reducing ROS accumulation suppressed retinal degeneration. Our results suggest that i-AAA is essential for removing unfolded proteins and maintaining mitochondrial membrane architecture. Loss of i-AAA leads to the accumulation of oxidative damage and progressive deterioration of membrane integrity, which might contribute to apoptosis upon the release of proapoptotic molecules such as dOmi. Containing ROS level could be a potential strategy to manage mitochondrial AAA protease deficiency.

  7. Structural and population-based evaluations of TBC1D1 p.Arg125Trp.

    Directory of Open Access Journals (Sweden)

    Tom G Richardson

    Full Text Available Obesity is now a leading cause of preventable death in the industrialised world. Understanding its genetic influences can enhance insight into molecular pathogenesis and potential therapeutic targets. A non-synonymous polymorphism (rs35859249, p.Arg125Trp in the N-terminal TBC1D1 phosphotyrosine-binding (PTB domain has shown a replicated association with familial obesity in women. We investigated these findings in the Avon Longitudinal Study of Parents and Children (ALSPAC, a large European birth cohort of mothers and offspring, and by generating a predicted model of the structure of this domain. Structural prediction involved the use of three separate algorithms; Robetta, HHpred/MODELLER and I-TASSER. We used the transmission disequilibrium test (TDT to investigate familial association in the ALSPAC study cohort (N = 2,292 mother-offspring pairs. Linear regression models were used to examine the association of genotype with mean measurements of adiposity (Body Mass Index (BMI, waist circumference and Dual-energy X-ray absorptiometry (DXA assessed fat mass, and logistic regression was used to examine the association with odds of obesity. Modelling showed that the R125W mutation occurs in a location of the TBC1D1 PTB domain that is predicted to have a function in a putative protein:protein interaction. We did not detect an association between R125W and BMI (mean per allele difference 0.27 kg/m(2 (95% Confidence Interval: 0.00, 0.53 P = 0.05 or obesity (odds ratio 1.01 (95% Confidence Interval: 0.77, 1.31, P = 0.96 in offspring after adjusting for multiple comparisons. Furthermore, there was no evidence to suggest that there was familial association between R125W and obesity (χ(2 = 0.06, P = 0.80. Our analysis suggests that R125W in TBC1D1 plays a role in the binding of an effector protein, but we find no evidence that the R125W variant is related to mean BMI or odds of obesity in a general population sample.

  8. Reaction of Br/sub 3/. /sup 2 -/ with 2-deoxy-D-ribose. A preferred attack at C-1

    Energy Technology Data Exchange (ETDEWEB)

    Parsons, B J; Schulte-Frohlinde, D; von Sonntag, C [Max-Planck-Institut fuer Kohlenforschung, Muelheim an der Ruhr (Germany, F.R.). Inst. fuer Strahlenchemie

    1978-06-01

    In the photolysis of 5-bromouracil containing DNA Br atoms are expected intermediates. In order to evaluate the possible site of attack of the Br atom at the sugar moiety of DNA the reaction of 2-deoxy-D-Ribose with the Br atom (complexed with two bromide ions) was investigated. Hydroxyl radicals generated by the radiolysis of N/sub 2/O saturated aqueous solutions were converted into Br/sub 3/./sup 2 -/-radicals by 1 M bromide ions. Br/sub 3/./sup 2 -/-reacts with 2-deoxy-D-ribose (k = 3.7 x 10/sup 4/M/sup -1/s/sup -1/, pulse radiolysis). The major product is 2-deoxy-D-erythro-pentonic acid (G = 2.4, ..gamma..-radiolysis). It is formed by hydrogen abstraction from C-1 and oxidation of this radical by other radicals. An alternative route via the radical at C-2 is neglible. It follows that Br/sub 3/./sup 2 -/ reacts preferentially at C-1 of 2-deoxy-D-ribose.

  9. Statistical pulses generator. Application to nuclear instrumentation (1962); Generateur d'impulsions aleatoires. Application a l'instrumentation nucleaire (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Beranger, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-07-01

    This report describes a random pulses generator adapted to nuclear instrumentation. After a short survey on the statistical nature of electronic signals, the different ways for generating pulses with a Poisson's time-distribution are studied. The final generator built from a gaseous thyratron in a magnetic field is then described. Several tests are indicated : counting-rate stability, Pearson's criterion, distribution of time-intervals. Applications of the generator in 'whole testing' of nuclear instrumentation are then indicated for sealers, dead time measurements, time analyzers. In this application, pulse-height spectrums have been made by Poissonian sampling of a recurrent or random low-frequency signal. (author) [French] Cette etude decrit un generateur d'impulsions aleatoires et ses applications a l'instrumentation nucleaire. Apres un bref rappel sur la nature statistique des signaux en electronique nucleaire, sont passes en revue les principaux moyens d'obtenir des impulsions distribuees en temps suivant une loi de Poisson. Le generateur utilisant un thyratron a gaz dans un champ magnetique est ensuite decrit; diverses methodes de test sont appliquees (stabilite du taux de comptage, criterium de Pearson, spectre des intervalles ds temps). Les applications du generateur a l'electronique nucleaire dans le domaine des 'essais globaux' sont indiques: test des echelles de comptage et mesure des temps morts, test des analyseurs en temps apres division du taux de comptage par une puissance de deux, test des analyseurs multicanaux en amplitude. Pour cette derniere application, on a realise des spectres d'amplitudes suivant une loi connue, par echantillonnage poissonien d'un signal basse frequence recurrent ou aleatoire. (auteur)

  10. Determination of broadband moment magnitude (Mwp) for August 11, 2009 Suruga-Bay earthquake (MJMA=6.5)

    Science.gov (United States)

    Tsuboi, S.; Hirshorn, B. F.

    2009-12-01

    We have determined Mwp for the August 11, 2009 Suruga-Bay earthquake (MJMA=6.5) using broadband seismograms recorded at close epicentral distance stations. We have used two broadband seismograph stations: JHJ2 (epicentral distance 1.9 degree) and FUJ (epicentral distance 0.44 degree). Because of the close epicentral distance of FUJ, the seismogram is clipped at about 10 second after the P-wave arrival. However, it was possible to use the first 10 second of this seismogram to compute Mwp. We get Mwp=6.4 for JHJ2 and 6.8 for FUJ(figure 1). After we apply Whitmore et al (2000)’s correction and average these two stations, we get Mwp=6.6 for this event. The epicentral distance of 0.44 degree for magnitude 6.5 earthquake is marginal to treat this seismogram as far-field. However, considering the aftershock distribution, the fault area seems to be limited to within the Suruga-Bay, which may confirm the fact that Mwp can be successfully computed at FUJ based on the far-field approximation. This result is significant in using Mwp from close epicentral distance seismograms to issue early tsunami warning. A large earthquake with Mw=7.5 (GCMT) occurred in Andaman Island, India, 10 minutes before this Suruga-Bay event. This made it very difficult to estimate Mwp for the Suruga-Bay event from broadband seismograms at teleseismic distances because of the large amplitude of Mw7.5 Andaman Island earthquake. In this case, it is therefore difficult to issue accurate tsunami warnings based on the teleseismic stations. We used broadband seismograms recorded by F-net operated by the National Research Institute for Earth Science and Disaster Prevention.

  11. Production of the excited charm mesons D{sub 1} and D{sup *}{sub 2} at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Verbytskyi, Andrii

    2013-02-15

    The production of the excited charm mesons D{sub 1}, D{sup *}{sub 2} and D{sup +}{sub s1} in ep collisions has been measured with the ZEUS detector at Hera. The data sample taken by the ZEUS detector in the years 2003-2007, corresponding to an integrated luminosity of 373 pb{sup -1} has been used. The masses of the neutral, charged and strange states, the widths of the neutral states, the helicity parameters of D{sup 0}{sub 1} and D{sup +}{sub s1} were determined and compared with other measurements and with theoretical expectations. The measured helicity parameters of the D{sup 0}{sub 1} and D{sup +}{sub s1} allows for some mixing of S- and D-waves in their decays to D{sup *{+-}}{pi}{sup -+} and D{sup *{+-}}K{sup 0} respectively. The measured value of the D{sup 0}{sub 1} helicity parameter is also consistent with a pure D-wave decay. Ratios of branching fractions of the two decay modes of the D{sup *0}{sub 2}, D{sup *{+-}}{sub 2} and D{sup +}{sub s1} states were measured and compared with previous measurements. The fractions of charm quarks hadronising into D{sub 1}, D{sup *}{sub 2} and D{sup +}{sub s1} were measured and are consistent with those obtained in e{sup +}e{sup -} annihilations. The Grid computing technology has a high importance for modern High Energy Physics. This technology has been successfully used in Zeus experiment for the MC simulations and data analysis. The dedicated infrastructure has been maintained by the author since 2010. In addition to continuous support, the author has upgraded and improved the performance of the Grid MC simulations and contributed to the Zeus data preservation project.

  12. Automated assignment and 3D structure calculations using combinations of 2D homonuclear and 3D heteronuclear NOESY spectra

    International Nuclear Information System (INIS)

    Oezguen, Numan; Adamian, Larisa; Xu Yuan; Rajarathnam, Krishna; Braun, Werner

    2002-01-01

    The NOAH/DIAMOD suite uses feedback filtering and self-correcting distance geometry to generate 3D structures from unassigned NOESY spectra. In this study we determined the minimum set of experiments needed to generate a high quality structure bundle. Different combinations of 3D 15 N-edited, 13 C-edited HSQC-NOESY and 2D homonuclear 1 H- 1 H NOESY spectra of the 77 amino acid protein, myeloid progenitor inhibitory factor-1 (MPIF-1) were used as input for NOAH/DIAMOD calculations. The quality of the assignments of NOESY cross peaks and the accuracy of the automatically generated 3D structures were compared to those obtained with a conventional manual procedure. Combining data from two types of experiments synergistically increased the number of peaks assigned unambiguously in both individual spectra. As a general trend for the accuracy of the structures we observed structural variations in the backbone fold of the final structures of about 2 A for single spectral data, of 1 A to 1.5 A for double spectral data, and of 0.6 A for triple spectral data sets. The quality of the assignments and 3D structures from the optimal data using all three spectra were similar to those obtained from traditional assignment methods with structural variations within the bundle of 0.6 A and 1.3 A for backbone and heavy atoms, respectively. Almost all constraints (97%) of the automatic NOESY cross peak assignments were cross compatible with the structures from the conventional manual assignment procedure, and an even larger proportion (99%) of the manually derived constraints were compatible with the automatically determined 3D structures. The two mean structures determined by both methods differed only by 1.3 A rmsd for the backbone atoms in the well-defined regions of the protein. Thus NOAD/DIAMOD analysis of spectra from labeled proteins provides a reliable method for high throughput analysis of genomic targets

  13. Stability and accuracy of 3D neutron transport simulations using the 2D/1D method in MPACT

    International Nuclear Information System (INIS)

    Collins, Benjamin; Stimpson, Shane; Kelley, Blake W.; Young, Mitchell T.H.; Kochunas, Brendan; Graham, Aaron; Larsen, Edward W.; Downar, Thomas; Godfrey, Andrew

    2016-01-01

    A consistent “2D/1D” neutron transport method is derived from the 3D Boltzmann transport equation, to calculate fuel-pin-resolved neutron fluxes for realistic full-core Pressurized Water Reactor (PWR) problems. The 2D/1D method employs the Method of Characteristics to discretize the radial variables and a lower order transport solution to discretize the axial variable. This paper describes the theory of the 2D/1D method and its implementation in the MPACT code, which has become the whole-core deterministic neutron transport solver for the Consortium for Advanced Simulations of Light Water Reactors (CASL) core simulator VERA-CS. Several applications have been performed on both leadership-class and industry-class computing clusters. Results are presented for whole-core solutions of the Watts Bar Nuclear Power Station Unit 1 and compared to both continuous-energy Monte Carlo results and plant data.

  14. Stability and accuracy of 3D neutron transport simulations using the 2D/1D method in MPACT

    Energy Technology Data Exchange (ETDEWEB)

    Collins, Benjamin, E-mail: collinsbs@ornl.gov [Oak Ridge National Laboratory, One Bethel Valley Rd., Oak Ridge, TN 37831 (United States); Stimpson, Shane, E-mail: stimpsonsg@ornl.gov [Oak Ridge National Laboratory, One Bethel Valley Rd., Oak Ridge, TN 37831 (United States); Kelley, Blake W., E-mail: kelleybl@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Young, Mitchell T.H., E-mail: youngmit@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Kochunas, Brendan, E-mail: bkochuna@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Graham, Aaron, E-mail: aarograh@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Larsen, Edward W., E-mail: edlarsen@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Downar, Thomas, E-mail: downar@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Godfrey, Andrew, E-mail: godfreyat@ornl.gov [Oak Ridge National Laboratory, One Bethel Valley Rd., Oak Ridge, TN 37831 (United States)

    2016-12-01

    A consistent “2D/1D” neutron transport method is derived from the 3D Boltzmann transport equation, to calculate fuel-pin-resolved neutron fluxes for realistic full-core Pressurized Water Reactor (PWR) problems. The 2D/1D method employs the Method of Characteristics to discretize the radial variables and a lower order transport solution to discretize the axial variable. This paper describes the theory of the 2D/1D method and its implementation in the MPACT code, which has become the whole-core deterministic neutron transport solver for the Consortium for Advanced Simulations of Light Water Reactors (CASL) core simulator VERA-CS. Several applications have been performed on both leadership-class and industry-class computing clusters. Results are presented for whole-core solutions of the Watts Bar Nuclear Power Station Unit 1 and compared to both continuous-energy Monte Carlo results and plant data.

  15. Generation of a suite of 3D computer-generated breast phantoms from a limited set of human subject data

    International Nuclear Information System (INIS)

    Hsu, Christina M. L.; Palmeri, Mark L.; Segars, W. Paul; Veress, Alexander I.; Dobbins, James T. III

    2013-01-01

    three human subject datasets, were used in a preliminary observer evaluation where four board certified breast radiologists with varying amounts of experience ranked the level of realism (from 1 =“fake” to 10 =“real”) of the simulated images. Results: The morphing technique was able to successfully generate new and unique morphed datasets from the original human subject data. The radiologists evaluated the realism of simulated mammograms generated from the morphed and unmorphed human subject datasets and scored the realism with an average ranking of 5.87 ± 1.99, confirming that overall the phantom image datasets appeared more “real” than “fake.” Moreover, there was not a significant difference (p > 0.1) between the realism of the unmorphed datasets (6.0 ± 1.95) compared to the morphed datasets (5.86 ± 1.99). Three of the four observers had overall average rankings of 6.89 ± 0.89, 6.9 ± 1.24, 6.76 ± 1.22, whereas the fourth observer ranked them noticeably lower at 2.94 ± 0.7. Conclusions: This work presents a technique that can be used to generate a suite of realistic computerized breast phantoms from a limited number of human subjects. This suite of flexible breast phantoms can be used for multimodality imaging research to provide a known truth while concurrently producing realistic simulated imaging data.

  16. Reactions of carbon radicals generated by 1,5-transposition of reactive centers

    Directory of Open Access Journals (Sweden)

    ZIVORAD CEKOVIC

    2005-03-01

    Full Text Available Radical intermediates can undergo specific reactions, such as intramolecular rearrangements, i.e., the transpositions of radical centers, which are not known in classical ionic organic reactions. 1,5-Transposition of a radical center to a non-activated carbon atom are of great synthetic importance. It can be successfully applied for the introduction of different functional groups (oxygen, nitrogen, sulfur, halogens onto a carbon atom remote from the present functional group. In addition to functionalization of a remote non-activated carbon atom, the formation of new C-C bonds on the d-carbon atom have also been achieved. 1,5-Transposition of the radical centers takes place from alkoxyl, aminyl and carbon radicals to a remote carbon atom. Relocation of the radical centers preferentially involves 1,5-transfer of a hydrogen atom, although migrations of some other groups are known. The reactions of the carbon radical generated by 1,5-relocation of the radical center are presented and their synthetic applications are reviewed.

  17. A facile route for 3D aerogels from nanostructured 1D and 2D materials

    Science.gov (United States)

    Jung, Sung Mi; Jung, Hyun Young; Dresselhaus, Mildred S.; Jung, Yung Joon; Kong, Jing

    2012-01-01

    Aerogels have numerous applications due to their high surface area and low densities. However, creating aerogels from a large variety of materials has remained an outstanding challenge. Here, we report a new methodology to enable aerogel production with a wide range of materials. The method is based on the assembly of anisotropic nano-objects (one-dimensional (1D) nanotubes, nanowires, or two-dimensional (2D) nanosheets) into a cross-linking network from their colloidal suspensions at the transition from the semi-dilute to the isotropic concentrated regime. The resultant aerogels have highly porous and ultrafine three-dimensional (3D) networks consisting of 1D (Ag, Si, MnO2, single-walled carbon nanotubes (SWNTs)) and 2D materials (MoS2, graphene, h-BN) with high surface areas, low densities, and high electrical conductivities. This method opens up a facile route for aerogel production with a wide variety of materials and tremendous opportunities for bio-scaffold, energy storage, thermoelectric, catalysis, and hydrogen storage applications. PMID:23152940

  18. D*± meson production at low Q2 with the H1 detector and determination of unintegrated gluon densities

    International Nuclear Information System (INIS)

    Cholewa, Axel

    2011-02-01

    A study of inclusive D *± meson production in deep inelastic electron-proton scattering at the H1 detector is presented for low photon virtualities. The results of these measurements have been used to determine unintegrated gluon densities with the Monte Carlo generator CASCADE. The phase space of the measurement is defined by photon virtualities inside 2 GeV 2 2 2 , and inelasticities inside 0.02 *± mesons is restricted to pseudo rapidities of vertical stroke η D * vertical stroke t D * >1.5 GeV and complements D *± meson production measurements at higher photon virtualities. Data taken in the years 2004-2007 during the HERA II running period have been analyzed yielding an integrated luminosity of 348 pb -1 . This significant increase in statistics compared to HERA I was exploited in the single and double differential cross sections which have been measured more differentiated than in previous measurements at H1. The single differential cross sections have been used in parameter fits of unintegrated gluon densities. For this purpose scattering events in electron-proton collisions were simulated with the Monte Carlo generator CASCADE and the deviation of the prediction of the simulation from the measured data was then minimized with the χ 2 method. Three different parametrizations of unintegrated gluon distributions have been used and compared. (orig.)

  19. Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins.

    Science.gov (United States)

    Mills, Natalie T; Wright, Margie J; Henders, Anjali K; Eyles, Darryl W; Baune, Bernhard T; McGrath, John J; Byrne, Enda M; Hansell, Narelle K; Birosova, Eva; Scott, James G; Martin, Nicholas G; Montgomery, Grant W; Wray, Naomi R; Vinkhuyzen, Anna A E

    2015-02-01

    Cytokines and vitamin D both have a role in modulating the immune system, and are also potentially useful biomarkers in mental illnesses such as major depressive disorder (MDD) and schizophrenia. Studying the variability of cytokines and vitamin D in a healthy population sample may add to understanding the association between these biomarkers and mental illness. To assess genetic and environmental contributions to variation in circulating levels of cytokines and vitamin D (25-hydroxy vitamin D: 25(OH)D3), we analyzed data from a healthy adolescent twin cohort (mean age 16.2 years; standard deviation 0.25). Plasma cytokine measures were available for 400 individuals (85 MZ, 115 DZ pairs), dried blood spot sample vitamin D measures were available for 378 individuals (70 MZ, 118 DZ pairs). Heritability estimates were moderate but significant for the cytokines transforming growth factor-β1 (TGF-β1), 0.57 (95% CI 0.26-0.80) and tumor necrosis factor-receptor type 1 (TNFR1), 0.50 (95% CI 0.11-0.63) respectively. Measures of 25(OH)D3 were within normal range and heritability was estimated to be high (0.86, 95% CI 0.61-0.94). Assays of other cytokines did not generate meaningful results. These potential biomarkers may be useful in mental illness, with further research warranted in larger sample sizes. They may be particularly important in adolescents with mental illness where diagnostic uncertainty poses a significant clinical challenge.

  20. D=1 supergravity and spinning particles

    International Nuclear Information System (INIS)

    Holten, J.W. van.

    1995-01-01

    In this paper I review the multiplet calculus of N-1, D=1 local supersymmetry with applications to the construction of models for spinning particles in background fields, and models with space-time supersymmetry. New features include a non-linear realization of the local supersymmetry algebra and the coupling to anti-symmetric tensor fields of both odd and even rank. The non-linear realization allows the construction of a D=1 cosmological-constant term, which provides a mass term in the equations of motion. (orig.)

  1. Power Quality Improvement Of Grid Integrated Type I Wind Turbine Generation System Operating as DSTATCOM by d-q Control Method

    Directory of Open Access Journals (Sweden)

    S V S Phani Kumar.Ch

    2016-06-01

    Full Text Available In recent years with the excessive consumption of electrical energy, the incongruity between generation and demand, the irrational structure of World’s energy as well as the environmental pollution have become progressively more evident. It has become crucial for ecological development to reduce the consumption of conventional energy and to enhance the development and utilization of renewable energy. Wind energy and Solar are unlimited supply of renewable energy and it has no pollution. But this concept suffer from the power quality issues from grid and generator side, this paper presents a control strategy for achieving maximum benefits from these grid-interfacing inverter when installed in 3-phase 4-wire distribution systems. The inverter can be controlled to perform as a multi-function device by incorporating active power filter functionality. The inverter can thus be utilized as: 1 power converter to inject power generated from RES to the grid and 2 shunt APF (Active Power Filter to compensate current unbalance, load current harmonics, load reactive power demand and load neutral current. All of these functions may be accomplished either individually or simultaneously. With such a control, the combination of grid-interfacing inverter and the 3-phase 4-wire linear/non-linear unbalanced load at point of common coupling appears as balanced linear load to the grid. The Paper propose design of 500kW Type I Wind Generation System 250kW each with Four Leg Inverter Controlled by d-q technique operated as DSTATCOM connected to 415V 4 wire Grid and also the results are compared with conventional Unit Vector Control. The proposed d-q method reduces the %THD of system to 1.97% from 24.12% where Unit Vector Control is of 3.94% which was on higher side , this is simulated in MATLAB/SIMULINK.

  2. Synthesis of α- and β-D-glucopyranuronate 1-phosphate and α-D-glucopyranuronate 1-fluoride: intermediates in the synthesis of D-glucuronic acid from starch

    NARCIS (Netherlands)

    Heeres, André; Van Doren, Henk A.; Gotlieb, Kees F.; Bleeker, Ido P.

    1997-01-01

    The title uronates were prepared by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) catalysed sodium hypochlorite oxidation of α- and β-D-glucopyranosylphosphate (α-/β-Glc-1-P) and α-D-glucopyranosyl fluoride (α-Glc-1-F). Quantitative recovery of the TEMPO catalyst was achieved by azeotropic

  3. Does one-dimensional (1D) adatom and cluster diffusion of Pt on the Pt(110)-(1 x 2) surface lead to 1D ripening?

    International Nuclear Information System (INIS)

    Linderoth, T R; Horch, S; Petersen, L; Laegsgaard, E; Stensgaard, I; Besenbacher, F

    2005-01-01

    The technique of scanning tunnelling microscopy (STM) uniquely allows dynamic processes on surfaces to be followed directly in real space and at atomic resolution. Results for the 551225 surface diffusion of Pt adatoms and clusters on the anisotropic, missing row reconstructed Pt(110)-(1 x 2) surface are briefly reviewed. Mass transport in this system is entirely one-dimensional (1D) since, at low adatom coverage, atoms and clusters are confined to the missing row troughs. In this paper, we therefore address the question if Pt/Pt(110)-(1 x 2) is a 1D model system to study late stage growth phenomena such as island ripening? From STM measurements, we quantify the morphology changes resulting from annealing a surface configuration with small 1D Pt islands in the missing row troughs to temperatures in the interval 369-395 K. Interestingly, the resulting increase in island sizes (ripening) cannot be accounted for by the known island and adatom mobilities within a 1D model. An explanation is provided from dynamic, time-resolved 'STM-movies' that directly reveal two novel island-mediated mechanisms for inter-trough mass transport which cause the Pt/Pt(110)-(1 x 2) system not to be purely 1D at the higher surface coverage used in the annealing experiments

  4. Comparison and analysis of 1D/2D/3D neutronics modeling for a fusion reactor

    International Nuclear Information System (INIS)

    Li, J.; Zeng, Q.; Chen, M.; Jiang, J.; Wu, Y.

    2007-01-01

    During the course of analyzing the characteristics for fusion reactors, the refined calculations are needed to confirm that the nuclear design requirements are met. Since the long computational time is consumed, the refined three-dimensional (3D) representation has been used primarily for establishing the baseline reference values, analyzing problems which cannot be reduced by symmetry considerations to lower dimensions, or where a high level of accuracy is desired locally. The two-dimensional (2D) or one-dimensional (1D) description leads itself readily to resolve many problems, such as the studies for the material fraction optimization, or for the blanket size optimization. The purpose of this paper is to find out the differences among different geometric descriptions, which can guide the way to approximate and simplify the computational model. The fusion power reactor named FDS-II was designed as an advanced fusion power reactor to demonstrate and validate the commercialization of fusion power by Institute of Plasma Physics, Chinese Academy of Science. In this contribution, the dual-cooled lithium lead (DLL) blanket of FDS-II was used as a reference for neutronics comparisons and analyses. The geometric descriptions include 1D concentric sphere model, 1D, 2D and 3D cylinder models. The home-developed multi-functional neutronics analysis code system VisualBUS, the Monte Carlo transport code MCNP and nuclear data library HENDL have been used for these analyses. The neutron wall loading distribution, tritium breeding ratio (TBR) and nuclear heat were calculated to evaluate the nuclear performance. The 3D calculation has been used as a comparison reference because it has the least errors in the treatment of geometry. It is suggested that the value of TBR calculated by the 1D approach should be greater than 1.3 to satisfy the practical need of tritium self-sufficiency. The distribution of nuclear heat based on the 2D and 3D models were similar since they all consider

  5. Giant magnons in the D1-D5 system

    International Nuclear Information System (INIS)

    David, Justin R.; Sahoo, Bindusar

    2008-01-01

    We study giant magnons in the the D1-D5 system from both the boundary CFT and as classical solutions of the string sigma model in AdS 3 x S 3 x T 4 . Re-examining earlier studies of the symmetric product conformal field theory we argue that giant magnons in the symmetric product are BPS states in a centrally extended SU(1|1) x SU(1|1) superalgebra with two more additional central charges. The magnons carry these additional central charges locally but globally they vanish. Using a spin chain description of these magnons and the extended superalgebra we show that these magnons obey a dispersion relation which is periodic in momentum. We then identify these states on the string theory side and show that here too they are BPS in the same centrally extended algebra and obey the same dispersion relation which is periodic in momentum. This dispersion relation arises as the BPS condition for the extended algebra and is similar to that of magnons in N = 4 Yang-Mills

  6. 3D model generation using an airborne swarm

    Energy Technology Data Exchange (ETDEWEB)

    Clark, R. A.; Punzo, G.; Macdonald, M. [Department of Mechanical and Aerospace Engineering, University of Strathclyde, Glasgow, G1 1XW (United Kingdom); Dobie, G.; MacLeod, C. N.; Summan, R.; Pierce, G. [Centre for Ultrasonic Engineering, University of Strathclyde, Glasgow, G1 1XW (United Kingdom); Bolton, G. [National Nuclear Laboratory Limited, Chadwick House, Warrington Road, Birchwood Park, Warrington, WA3 6AE (United Kingdom)

    2015-03-31

    Using an artificial kinematic field to provide co-ordination between multiple inspection UAVs, the authors herein demonstrate full 3D modelling capability based on a photogrammetric system. The operation of the system is demonstrated by generating a full 3D surface model of an intermediate level nuclear waste storage drum. Such drums require periodic inspection to ensure that drum distortion or corrosion is carefully monitored. Performing this inspection with multiple airborne platforms enables rapid inspection of structures that are inaccessible to on-surface remote vehicles and are in human-hazardous environments. A three-dimensional surface-meshed model of the target can then be constructed in post-processing through photogrammetry analysis of the visual inspection data. The inspection environment uses a tracking system to precisely monitor the position of each aerial vehicle within the enclosure. The vehicles used are commercially available Parrot AR. Drone quadcopters, controlled through a computer interface connected over an IEEE 802.11n (WiFi) network, implementing a distributed controller for each vehicle. This enables the autonomous and distributed elements of the control scheme to be retained, while alleviating the vehicles of the control algorithm’s computational load. The control scheme relies on a kinematic field defined with the target at its centre. This field defines the trajectory for all the drones in the volume relative to the central target, enabling the drones to circle the target at a set radius while avoiding drone collisions. This function enables complete coverage along the height of the object, which is assured by transitioning to another inspection band only after completing circumferential coverage. Using a swarm of vehicles, the time until complete coverage can be significantly reduced.

  7. 3D model generation using an airborne swarm

    International Nuclear Information System (INIS)

    Clark, R. A.; Punzo, G.; Macdonald, M.; Dobie, G.; MacLeod, C. N.; Summan, R.; Pierce, G.; Bolton, G.

    2015-01-01

    Using an artificial kinematic field to provide co-ordination between multiple inspection UAVs, the authors herein demonstrate full 3D modelling capability based on a photogrammetric system. The operation of the system is demonstrated by generating a full 3D surface model of an intermediate level nuclear waste storage drum. Such drums require periodic inspection to ensure that drum distortion or corrosion is carefully monitored. Performing this inspection with multiple airborne platforms enables rapid inspection of structures that are inaccessible to on-surface remote vehicles and are in human-hazardous environments. A three-dimensional surface-meshed model of the target can then be constructed in post-processing through photogrammetry analysis of the visual inspection data. The inspection environment uses a tracking system to precisely monitor the position of each aerial vehicle within the enclosure. The vehicles used are commercially available Parrot AR. Drone quadcopters, controlled through a computer interface connected over an IEEE 802.11n (WiFi) network, implementing a distributed controller for each vehicle. This enables the autonomous and distributed elements of the control scheme to be retained, while alleviating the vehicles of the control algorithm’s computational load. The control scheme relies on a kinematic field defined with the target at its centre. This field defines the trajectory for all the drones in the volume relative to the central target, enabling the drones to circle the target at a set radius while avoiding drone collisions. This function enables complete coverage along the height of the object, which is assured by transitioning to another inspection band only after completing circumferential coverage. Using a swarm of vehicles, the time until complete coverage can be significantly reduced

  8. Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons.

    Science.gov (United States)

    Yapo, Cedric; Nair, Anu G; Clement, Lorna; Castro, Liliana R; Hellgren Kotaleski, Jeanette; Vincent, Pierre

    2017-12-15

    Brief dopamine events are critical actors of reward-mediated learning in the striatum; the intracellular cAMP-protein kinase A (PKA) response of striatal medium spiny neurons to such events was studied dynamically using a combination of biosensor imaging in mouse brain slices and in silico simulations. Both D1 and D2 medium spiny neurons can sense brief dopamine transients in the sub-micromolar range. While dopamine transients profoundly change cAMP levels in both types of medium spiny neurons, the PKA-dependent phosphorylation level remains unaffected in D2 neurons. At the level of PKA-dependent phosphorylation, D2 unresponsiveness depends on protein phosphatase-1 (PP1) inhibition by DARPP-32. Simulations suggest that D2 medium spiny neurons could detect transient dips in dopamine level. The phasic release of dopamine in the striatum determines various aspects of reward and action selection, but the dynamics of the dopamine effect on intracellular signalling remains poorly understood. We used genetically encoded FRET biosensors in striatal brain slices to quantify the effect of transient dopamine on cAMP or PKA-dependent phosphorylation levels, and computational modelling to further explore the dynamics of this signalling pathway. Medium-sized spiny neurons (MSNs), which express either D 1 or D 2 dopamine receptors, responded to dopamine by an increase or a decrease in cAMP, respectively. Transient dopamine showed similar sub-micromolar efficacies on cAMP in both D1 and D2 MSNs, thus challenging the commonly accepted notion that dopamine efficacy is much higher on D 2 than on D 1 receptors. However, in D2 MSNs, the large decrease in cAMP level triggered by transient dopamine did not translate to a decrease in PKA-dependent phosphorylation level, owing to the efficient inhibition of protein phosphatase 1 by DARPP-32. Simulations further suggested that D2 MSNs can also operate in a 'tone-sensing' mode, allowing them to detect transient dips in basal dopamine

  9. Molecular and crystal structure and the Hirshfeld surface analysis of 1-amino-1-deoxy-α-D-sorbopyranose and 1-amino-1-deoxy-α-D-psicopyranose ("D-sorbosamine" and "D-psicosamine") derivatives

    Science.gov (United States)

    Mossine, Valeri V.; Barnes, Charles L.; Mawhinney, Thomas P.

    2018-05-01

    Sorbosamine and psicosamine are the last two 1-amino-1-deoxy-hexuloses for which no structural data were available. We report on a13C NMR and a single crystal X-ray diffraction study of 1-deoxy-1-(N-methylphenylamino)-D-sorbose (1) and 1-deoxy-1-(N-methylphenylamino)-D-psicose (2). In solutions, both aminosugars are conformationally unstable and establish equilibria, with 90.7% α-pyranose, 3.8% α-furanose, 1.0% β-pyranose, 0.5% β-furanose, and 4.0% acyclic keto form for 1 and 32.4% α-furanose, 27.2% α-pyranose, 21.0% β-pyranose, 9.1% β-furanose, and 11.0% acyclic keto form for 2. X-ray diffraction data provided detailed structural information on 1 and 2 in the α-pyranose form. Both molecules adopt the 5C2 ring conformations, the bond distances and valence angles compare well with respective pyranose structures. All hydroxyl groups in crystal structures of both 1 and 2 participate in two-dimensional hydrogen bonding networks, the H-bonding pattern in 1 is dominated by co-crystallized water molecules. The Hirshfeld surface analysis revealed a significant contribution of non- or weakly polar interactions to the packing forces for both molecules, with crystal structure of 2 featuring short H⋯H contacts. Other structural features found in 2 are a significant planarity of the tertiary amino group (the pyramid heights are 0.127 Å in 2 vs 0.231 Å in 1), a concomitant non-involvement of the amine nitrogen in heteroatom contacts, and a unique anti-periplanar conformation around the C1sbnd C2 bond.

  10. Vitamin D and pancreatic cancer

    OpenAIRE

    Stolzenberg-Solomon, Rachael Z.

    2008-01-01

    Sun exposure has been associated with lower death rates for pancreatic cancer in ecological studies. Skin exposure to solar ultra-violet B radiation induces cutaneous production of precursors to 25-hydroxy (OH) vitamin D (D) and is considered the primary contributor to vitamin D status in most populations. Pancreatic islet and duct cells express 25-(OH) D3-1α-hydroxylase that generates the biologically active 1,25-dihydroxy(OH)2 D form. Thus, 25(OH)D concentrations could affect pancreatic fun...

  11. 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase-Dependent Stimulation of Renal Klotho Expression by Spironolactone

    Directory of Open Access Journals (Sweden)

    Ioana Alesutan

    2013-11-01

    Full Text Available Background: Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney, is required for the suppression of 1,25(OH2D3-generating 25-hydroxyvitamin D3 1-alpha-hydroxylase (Cyp27b1 by FGF23. Conversely, 1,25(OH2D3 stimulates, by activating the vitamin D3 receptor (Vdr, the expression of klotho, thus establishing a negative feedback loop. Klotho protects against renal and vascular injury. Klotho deficiency accelerates aging and early death, effects at least partially due to excessive formation of 1,25(OH2D3 and subsequent hyperphosphatemia. Klotho expression is inhibited by aldosterone. The present study explored the interaction of aldosterone and DOCA as well as the moderately selective mineralocorticoid receptor antagonist spironolactone on klotho expression. Methods: mRNA levels were determined utilizing quantitative RT-PCR in human embryonic kidney cells (HEK293 or in renal tissues from mice without or with prior mineralocorticoid (aldosterone or DOCA and/or spironolactone treatment. In HEK293 cells, protein levels were determined by western blotting. The experiments in HEK293 cells were performed without or with silencing of CYP27B1, of vitamin D3 receptor (VDR or of mineralocorticoid receptor (NR3C2. Results: In HEK293 cells aldosterone and in mice DOCA significantly decreased KLOTHO gene expression, effects opposed by spironolactone treatment. Spironolactone treatment alone significantly increased KLOTHO and CYP27B1 transcript levels in HEK293 cells (24 hours and mice (8 hours or 5 days. Moreover, spironolactone significantly increased klotho and CYP27B1 protein levels in HEK293 cells (48 hours. Reduced NR3C2 expression following silencing did not significantly affect KLOTHO and CYP27B1 transcript levels in presence or absence of spironolactone. Silencing of CYP27B1 and VDR significantly blunted the stimulating effect of spironolactone on KLOTHO mRNA levels in HEK293 cells. Conclusion: Besides blocking the effects of

  12. Simulation of the Basin Effects in the Po Plain During the Emilia-Romagna Seismic Sequence (2012) Using Empirical Green's Functions

    Science.gov (United States)

    Dujardin, Alain; Causse, Mathieu; Courboulex, Françoise; Traversa, Paola

    2016-06-01

    The two main earthquakes that occurred in 2012 (May 20 and 29) in the Reggio-Emiliano region (Northern Italy) were relatively small (Mw 6.1 and Mw 5.9) but they generated unexpected damages in a large area around the epicenter. On some stations, the observed seismic levels exceeded design levels recommended by the EC8 seismic code for buildings and civil engineering works. The ground motions generated by the two mainshocks have specific characteristics: the waveforms are mainly controlled by surface waves generated by the deep sedimentary Po plain, by local site effects and also, on some stations, by non-linear behaviors. In this particular context, we test the ability of an empirical Green's function (EGF) simulation approach to reproduce the recorded seismograms in a large frequency band without any knowledge of the underground medium. We focus on the possibility to reproduce the strong surface waves generated by the basin at distances between 25 and 90 km. We choose to work on the second mainshock of the sequence (Mw 5.9), which occurred on May 29, 2012, because it is better recorded by the seismological networks than the May 20th first mainshock. We use a k-2 kinematic source model to generate a set of 100 slip distributions on the fault plane and choose the recordings of a close-by Mw 3.9 event as EGF. We then generate a set of broad-band seismograms (from 0.2 to 35 Hz) and compare them to the mainshock signals at 15 stations (Seismograms, Fourier spectra, PGA, PGV, duration, Stockwell Transforms) at epicentral distances from 5 to 160 km. We find that the main specific features of the signals are very well reproduced for all the stations within and beyond the basin. Nevertheless, at nearby stations, the PGA values are over-evaluated, which could be explained by the fact that non- linear effects are not taken into account in the simulation process. A better fit was found for a position of the nucleation point to the bottom west of the fault, that suggest a

  13. A neutron monitor for D-T neutron generator in the PGNAA-based online measurement system

    Science.gov (United States)

    Shan, Qing; Shengnan, Chu; Yongsheng, Ling; Pingkun, Cai; Wenbao, Jia

    2017-06-01

    A new type of neutron detector, which consists of polyethylene, an EJ200 plastic scintillator and fused silica, was proposed and optimized by the GEANT4 Monte Carlo simulation toolkit in our previous studies. The calculation method was also described for calculating the neutron flux in the preset condition. This paper reports the manufacturing of the prototype detector. Experiments are conducted to validate the feasibility of this detector. A D-T neutron generator and a 60Co gamma-ray source are used in the experiments. The designed detector and a He-3 proportional counter are simultaneously used to monitor the yield of the D-T neutron generator. A more universal calculation method is developed to enable the application of this detector to common conditions. The experimental results show that the performance of the designed detector is comparable to that of the He-3 proportional counter. The relative deviations between their normalized counts are less than 5%.

  14. LRSYS, PASCAL LR(1) Parser Generator System

    International Nuclear Information System (INIS)

    O'Hair, K.

    1991-01-01

    Description of program or function: LRSYS is a complete LR(1) parser generator system written entirely in a portable subset of Pascal. The system, LRSYS, includes a grammar analyzer program (LR) which reads a context-free (BNF) grammar as input and produces LR(1) parsing tables as output, a lexical analyzer generator (LEX) which reads regular expressions created by the REG process as input and produces lexical tables as output, and various parser skeletons that get merged with the tables to produce complete parsers (SMAKE). Current parser skeletons include Pascal, FORTRAN 77, and C. In addition, the CRAY1, DEC VAX11 version contains LRLTRAN and CFT- FORTRAN 77 skeletons. Other language skeletons can easily be added to the system. LRSYS is based on the LR program (NESC Abstract 822)

  15. Suramin blocks interaction between human FGF1 and FGFR2 D2 domain and reduces downstream signaling activity

    International Nuclear Information System (INIS)

    Wu, Zong-Sian; Liu, Che Fu; Fu, Brian; Chou, Ruey-Hwang; Yu, Chin

    2016-01-01

    The extracellular portion of the human fibroblast growth factor receptor2 D2 domain (FGFR2 D2) interacts with human fibroblast growth factor 1 (hFGF1) to activate a downstream signaling cascade that ultimately affects mitosis and differentiation. Suramin is an antiparasiticdrug and a potent inhibitor of FGF-induced angiogenesis. Suramin has been shown to bind to hFGF1, and might block the interaction between hFGF1 and FGFR2 D2. Here, we titrated hFGF1 with FGFR2 D2 and suramin to elucidate their interactions using the detection of NMR. The docking results of both hFGF1-FGFR2 D2 domain and hFGF1-suramin complex were superimposed. The results indicate that suramin blocks the interaction between hFGF1 and FGFR2 D2. We used the PyMOL software to show the hydrophobic interaction of hFGF1-suramin. In addition, we used a Water-soluble Tetrazolium salts assay (WST1) to assess hFGF1 bioactivity. The results will be useful for the development of new antimitogenic activity drugs. - Highlights: • The interfacial residues on hFGF1-FGFR2 D2 and hFGF1-Suramin contact surface were mapped by "1H-"1"5N HSQC experiments. • hFGF1-FGFR2 D2 and hFGF1-Suramin complex models were generated from NMR restraints by using HADDOCK program. • We analyzed hFGF1-Suramin complex models and found the interaction between hFGF1-Suramin is hydrophobic. • The bioactivity of the hFGF1-FGFR2 D2 and hFGF1-Suramin complex was studied by using WST1 assay.

  16. AUTOMATIC GENERATION OF ROAD INFRASTRUCTURE IN 3D FOR VEHICLE SIMULATORS

    Directory of Open Access Journals (Sweden)

    Adam Orlický

    2017-12-01

    Full Text Available One of the modern methods of testing new systems and interfaces in vehicles is testing in a vehicle simulator. Providing quality models of virtual scenes is one of tasks for driver-car interaction interface simulation. Nowadays, there exist many programs for creating 3D models of road infrastructures, but most of these programs are very expensive or canÂtt export models for the following use. Therefore, a plug-in has been developed at the Faculty of Transportation Sciences in Prague. It can generate road infrastructure by Czech standard for designing roads (CSN 73 6101. The uniqueness of this plug-in is that it is the first tool for generating road infrastructure in NURBS representation. This type of representation brings more exact models and allows to optimize transfer for creating quality models for vehicle simulators. The scenes created by this plug-in were tested on vehicle simulators. The results have shown that with newly created scenes drivers had a much better feeling in comparison to previous scenes.

  17. Optimized efficiency in InP nanowire solar cells with accurate 1D analysis

    Science.gov (United States)

    Chen, Yang; Kivisaari, Pyry; Pistol, Mats-Erik; Anttu, Nicklas

    2018-01-01

    Semiconductor nanowire arrays are a promising candidate for next generation solar cells due to enhanced absorption and reduced material consumption. However, to optimize their performance, time consuming three-dimensional (3D) opto-electronics modeling is usually performed. Here, we develop an accurate one-dimensional (1D) modeling method for the analysis. The 1D modeling is about 400 times faster than 3D modeling and allows direct application of concepts from planar pn-junctions on the analysis of nanowire solar cells. We show that the superposition principle can break down in InP nanowires due to strong surface recombination in the depletion region, giving rise to an IV-behavior similar to that with low shunt resistance. Importantly, we find that the open-circuit voltage of nanowire solar cells is typically limited by contact leakage. Therefore, to increase the efficiency, we have investigated the effect of high-bandgap GaP carrier-selective contact segments at the top and bottom of the InP nanowire and we find that GaP contact segments improve the solar cell efficiency. Next, we discuss the merit of p-i-n and p-n junction concepts in nanowire solar cells. With GaP carrier selective top and bottom contact segments in the InP nanowire array, we find that a p-n junction design is superior to a p-i-n junction design. We predict a best efficiency of 25% for a surface recombination velocity of 4500 cm s-1, corresponding to a non-radiative lifetime of 1 ns in p-n junction cells. The developed 1D model can be used for general modeling of axial p-n and p-i-n junctions in semiconductor nanowires. This includes also LED applications and we expect faster progress in device modeling using our method.

  18. Complete Suppression of the m=2/n=1 NTM Using ECCD on DIII-D

    International Nuclear Information System (INIS)

    Petty, C.C.; La Haye, R.J.; Luce, T.C.; Humphreys, D.A.; Lohr, J.; Prater, R.; Austin, M.E.; Harvey, R.W.; Wade, M.R.

    2003-01-01

    Complete suppression of the m=2/n=1 neoclassical tearing mode (NTM) is reported for the first time using electron cyclotron current drive (ECCD) to noninductively generate current at the radius of the island O-point. Experiments on the DIII-D tokamak show that the maximum shrinkage of the m=2/n=1 island amplitude occurs when the ECCD location coincides with the q=2 surface. Estimates of the ECCD radial profile width from the island shrinkage are consistent with ray tracing calculations but may allow for a factor-of-1.5 broadening from electron radial transport

  19. Suramin blocks interaction between human FGF1 and FGFR2 D2 domain and reduces downstream signaling activity

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Zong-Sian, E-mail: gary810426@hotmail.com [Department of Chemistry, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan (China); Liu, Che Fu, E-mail: s9823002@m98.nthu.edu.tw [Department of Chemistry, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan (China); Fu, Brian, E-mail: brianfu9@gmail.com [Northwood High School, Irvine, CA (United States); Chou, Ruey-Hwang, E-mail: rhchou@mail.cmu.edu.tw [Graduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical University, No.91, Hsueh-Shih Road, Taichung 40402, Taiwan (China); Department of Biotechnology, Asia University, Taiwan (China); Yu, Chin, E-mail: cyu.nthu@gmail.com [Department of Chemistry, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan (China)

    2016-09-02

    The extracellular portion of the human fibroblast growth factor receptor2 D2 domain (FGFR2 D2) interacts with human fibroblast growth factor 1 (hFGF1) to activate a downstream signaling cascade that ultimately affects mitosis and differentiation. Suramin is an antiparasiticdrug and a potent inhibitor of FGF-induced angiogenesis. Suramin has been shown to bind to hFGF1, and might block the interaction between hFGF1 and FGFR2 D2. Here, we titrated hFGF1 with FGFR2 D2 and suramin to elucidate their interactions using the detection of NMR. The docking results of both hFGF1-FGFR2 D2 domain and hFGF1-suramin complex were superimposed. The results indicate that suramin blocks the interaction between hFGF1 and FGFR2 D2. We used the PyMOL software to show the hydrophobic interaction of hFGF1-suramin. In addition, we used a Water-soluble Tetrazolium salts assay (WST1) to assess hFGF1 bioactivity. The results will be useful for the development of new antimitogenic activity drugs. - Highlights: • The interfacial residues on hFGF1-FGFR2 D2 and hFGF1-Suramin contact surface were mapped by {sup 1}H-{sup 15}N HSQC experiments. • hFGF1-FGFR2 D2 and hFGF1-Suramin complex models were generated from NMR restraints by using HADDOCK program. • We analyzed hFGF1-Suramin complex models and found the interaction between hFGF1-Suramin is hydrophobic. • The bioactivity of the hFGF1-FGFR2 D2 and hFGF1-Suramin complex was studied by using WST1 assay.

  20. Development of 99mTc-labelled the d,1-diasteroisomer of HM-PAO for cerebral blood flow imaging

    International Nuclear Information System (INIS)

    Lun Xiao.

    1989-10-01

    The d,1-diastereoisomer of hexamethyl propyleneamine oxime (HM-PAO) was selected as the preferred ligand for Tc-99m as a radiotracer for cerebral perfusion imaging. Further improvement of the synthesis and isolation method of HM-PAO resulted in pure d,1-HM-PAO and pure meso-HM-PAO. The neutral, lipophilic Tc-99m complexes of d,1-HM-PAO and meso-HM-PAO were formed in high yield by stannous reduction of Mo-99/Tc-99m generator eluate, respectively. Two minutes following i.v. administration of Tc-99m-d,1-HM-PAO in mice, 2.24% of the injected dose appears in the brain. Little washout of the tracer is observed up to 24-hour post injection. Two minutes following i.v. administration of Tc-99m-meso-HM-PAO in mice, 1.9% of the injected dose appears in the brain. The radioactivity of Tc-99m-meso-HM-PAO declined faster than that of Tc-99m-d,1-HM-PAO did in the brain up to 24-hour post injection. 12 refs, 5 figs, 5 tabs